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Search of human proteins with 6912286
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912286 caspase 14 precursor [Homo sapiens]
(242 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912286 caspase 14 precursor [Homo sapiens] 482 e-136
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap... 173 1e-43
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap... 173 1e-43
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 107 7e-24
gi|14790115 caspase 3 preproprotein [Homo sapiens] 102 3e-22
gi|14790119 caspase 3 preproprotein [Homo sapiens] 102 3e-22
gi|15718698 caspase 7 isoform delta [Homo sapiens] 100 2e-21
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 100 2e-21
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 100 2e-21
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 94 1e-19
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 94 1e-19
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 94 1e-19
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 94 1e-19
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 94 1e-19
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 94 1e-19
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 94 1e-19
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 86 4e-17
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 86 4e-17
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 82 3e-16
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 81 9e-16
gi|209870073 caspase 5 isoform c [Homo sapiens] 81 9e-16
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 81 9e-16
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 81 9e-16
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 80 2e-15
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 80 2e-15
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 80 2e-15
gi|15431332 caspase 1 isoform delta [Homo sapiens] 74 9e-14
gi|14916485 caspase 6 isoform beta [Homo sapiens] 72 4e-13
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 72 6e-13
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 72 6e-13
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 482 bits (1240), Expect = e-136
Identities = 242/242 (100%), Positives = 242/242 (100%)
Query: 1 MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQ 60
MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQ
Sbjct: 1 MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQ 60
Query: 61 FQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQAL 120
FQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQAL
Sbjct: 61 FQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQAL 120
Query: 121 RAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRH 180
RAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRH
Sbjct: 121 RAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRH 180
Query: 181 DQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLY 240
DQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLY
Sbjct: 181 DQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLY 240
Query: 241 LQ 242
LQ
Sbjct: 241 LQ 242
>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 173 bits (438), Expect = 1e-43
Identities = 109/261 (41%), Positives = 152/261 (58%), Gaps = 32/261 (12%)
Query: 11 KYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQ 70
+YD+S AR AL+L V + R G++ D++AL + L FE+T++ DPTA+ FQEEL +F++
Sbjct: 174 QYDLSKARAALLLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 71 AIDSREDPVSCAFVVLMAH-GREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYII 129
+D+ PVSCA V LMAH G G L G DG+ V+ E L + L+ CQ L+ +PK++++
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 130 QACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALH---------------------- 167
QACRG RD G +P ++P++ D L
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQAD 351
Query: 168 ---VYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGH-ILELLTEVTRRMAEAELVQE-- 221
VYS EGY+AYR D KGS FIQTLV+V G +LELLTEV RR+ E E++
Sbjct: 352 ILTVYSAAEGYVAYR-DDKGSDFIQTLVEVLRANPGRDLLELLTEVNRRVCEQEVLGPDC 410
Query: 222 GKARKTNPEIQSTLRKRLYLQ 242
+ RK EI+S+LR+RL LQ
Sbjct: 411 DELRKACLEIRSSLRRRLCLQ 431
>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
sapiens]
Length = 432
Score = 173 bits (438), Expect = 1e-43
Identities = 109/261 (41%), Positives = 152/261 (58%), Gaps = 32/261 (12%)
Query: 11 KYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQ 70
+YD+S AR AL+L V + R G++ D++AL + L FE+T++ DPTA+ FQEEL +F++
Sbjct: 174 QYDLSKARAALLLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFRE 233
Query: 71 AIDSREDPVSCAFVVLMAH-GREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYII 129
+D+ PVSCA V LMAH G G L G DG+ V+ E L + L+ CQ L+ +PK++++
Sbjct: 234 QLDTCRGPVSCALVALMAHGGPRGQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLL 291
Query: 130 QACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALH---------------------- 167
QACRG RD G +P ++P++ D L
Sbjct: 292 QACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQAD 351
Query: 168 ---VYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGH-ILELLTEVTRRMAEAELVQE-- 221
VYS EGY+AYR D KGS FIQTLV+V G +LELLTEV RR+ E E++
Sbjct: 352 ILTVYSAAEGYVAYR-DDKGSDFIQTLVEVLRANPGRDLLELLTEVNRRVCEQEVLGPDC 410
Query: 222 GKARKTNPEIQSTLRKRLYLQ 242
+ RK EI+S+LR+RL LQ
Sbjct: 411 DELRKACLEIRSSLRRRLCLQ 431
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 107 bits (268), Expect = 7e-24
Identities = 73/234 (31%), Positives = 123/234 (52%), Gaps = 28/234 (11%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G + D L +F+ L ++ + D TA++ QE+L+ F Q + + SC V L++
Sbjct: 219 RSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ-LPAHRVTDSC-IVALLS 276
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-------- 140
HG EG + G DG++++L+ +F+ +N NC +L+ KPK++ IQACRG++ D G
Sbjct: 277 HGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKN 336
Query: 141 --------ETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLV 192
E+ G E K +PT +D + Y+ ++G A R+ ++GS +I+ L
Sbjct: 337 HAGSPGCEESDAGKE-----KLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALA 391
Query: 193 DVFTKR--KGHILELLTEVTRRMAEAELVQEG---KARKTNPEIQSTLRKRLYL 241
VF++R H+ ++L +V + + E G K E STL + LYL
Sbjct: 392 QVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYL 445
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 102 bits (254), Expect = 3e-22
Identities = 74/220 (33%), Positives = 108/220 (49%), Gaps = 15/220 (6%)
Query: 28 AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM 87
+R G++ D L FR L++E K D T E+ E + + S+ C VL+
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVC---VLL 119
Query: 88 AHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-ETVGGD 146
+HG EG + G +G V L+ + C++L KPK++IIQACRG + D G ET G
Sbjct: 120 SHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGV 178
Query: 147 EIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILE 204
+ M IP D L+ YST GY ++R+ + GS FIQ+L + + K +
Sbjct: 179 DDDMAC----HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH 234
Query: 205 LLTEVTRRMA----EAELVQEGKARKTNPEIQSTLRKRLY 240
+LT V R++A A+K P I S L K LY
Sbjct: 235 ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 102 bits (254), Expect = 3e-22
Identities = 74/220 (33%), Positives = 108/220 (49%), Gaps = 15/220 (6%)
Query: 28 AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM 87
+R G++ D L FR L++E K D T E+ E + + S+ C VL+
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVC---VLL 119
Query: 88 AHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-ETVGGD 146
+HG EG + G +G V L+ + C++L KPK++IIQACRG + D G ET G
Sbjct: 120 SHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGV 178
Query: 147 EIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILE 204
+ M IP D L+ YST GY ++R+ + GS FIQ+L + + K +
Sbjct: 179 DDDMAC----HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH 234
Query: 205 LLTEVTRRMA----EAELVQEGKARKTNPEIQSTLRKRLY 240
+LT V R++A A+K P I S L K LY
Sbjct: 235 ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 99.8 bits (247), Expect = 2e-21
Identities = 67/218 (30%), Positives = 106/218 (48%), Gaps = 10/218 (4%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+++D +AL FR L F+ + D + + Q+ L+K A + +C +L++
Sbjct: 120 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK---ASEEDHTNAACFACILLS 176
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEI 148
HG E + G+DG + +++L C+ L KPK++ IQACRG + D G I
Sbjct: 177 HGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 235
Query: 149 VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILELL 206
+ IP D L YSTV GY ++R +GS F+Q L + + + I+++L
Sbjct: 236 NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQIL 295
Query: 207 TEVTRRMAEAELVQEG----KARKTNPEIQSTLRKRLY 240
T V R+A Q +K P + S L K LY
Sbjct: 296 TRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 333
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 99.8 bits (247), Expect = 2e-21
Identities = 67/218 (30%), Positives = 106/218 (48%), Gaps = 10/218 (4%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+++D +AL FR L F+ + D + + Q+ L+K A + +C +L++
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK---ASEEDHTNAACFACILLS 143
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEI 148
HG E + G+DG + +++L C+ L KPK++ IQACRG + D G I
Sbjct: 144 HGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
Query: 149 VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILELL 206
+ IP D L YSTV GY ++R +GS F+Q L + + + I+++L
Sbjct: 203 NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQIL 262
Query: 207 TEVTRRMAEAELVQEG----KARKTNPEIQSTLRKRLY 240
T V R+A Q +K P + S L K LY
Sbjct: 263 TRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 99.8 bits (247), Expect = 2e-21
Identities = 67/218 (30%), Positives = 106/218 (48%), Gaps = 10/218 (4%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+++D +AL FR L F+ + D + + Q+ L+K A + +C +L++
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK---ASEEDHTNAACFACILLS 143
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEI 148
HG E + G+DG + +++L C+ L KPK++ IQACRG + D G I
Sbjct: 144 HGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPI 202
Query: 149 VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILELL 206
+ IP D L YSTV GY ++R +GS F+Q L + + + I+++L
Sbjct: 203 NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQIL 262
Query: 207 TEVTRRMAEAELVQEG----KARKTNPEIQSTLRKRLY 240
T V R+A Q +K P + S L K LY
Sbjct: 263 TRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY 300
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 94.0 bits (232), Expect = 1e-19
Identities = 62/218 (28%), Positives = 105/218 (48%), Gaps = 9/218 (4%)
Query: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
K R+G+ +D + L H+F+ L F + + T + + L+K Q + C +
Sbjct: 298 KDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNPAHADGDCFVFCI 355
Query: 87 MAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGD 146
+ HGR G + D ++ + + C L KPK++ IQAC+GE+ P ++ D
Sbjct: 356 LTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEAD 415
Query: 147 EI--VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RKGH 201
+ +IP D L +TV GY+++RH ++GS +IQ+L + K R
Sbjct: 416 ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHED 475
Query: 202 ILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LT V ++ V + +K P+ TLRK+L
Sbjct: 476 ILSILTAVNDDVSRR--VDKQGTKKQMPQPAFTLRKKL 511
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 94.0 bits (232), Expect = 1e-19
Identities = 62/218 (28%), Positives = 105/218 (48%), Gaps = 9/218 (4%)
Query: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
K R+G+ +D + L H+F+ L F + + T + + L+K Q + C +
Sbjct: 255 KDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNPAHADGDCFVFCI 312
Query: 87 MAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGD 146
+ HGR G + D ++ + + C L KPK++ IQAC+GE+ P ++ D
Sbjct: 313 LTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEAD 372
Query: 147 EI--VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RKGH 201
+ +IP D L +TV GY+++RH ++GS +IQ+L + K R
Sbjct: 373 ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHED 432
Query: 202 ILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LT V ++ V + +K P+ TLRK+L
Sbjct: 433 ILSILTAVNDDVSRR--VDKQGTKKQMPQPAFTLRKKL 468
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 93.6 bits (231), Expect = 1e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 375
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 376 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 435
Query: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 436 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 495
Query: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 496 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 533
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 93.6 bits (231), Expect = 1e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 301
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 302 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 361
Query: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 362 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 421
Query: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 422 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 459
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 93.6 bits (231), Expect = 1e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 245 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 301
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 302 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 361
Query: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 362 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 421
Query: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 422 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 459
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 93.6 bits (231), Expect = 1e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 260 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 316
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 317 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 376
Query: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 377 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 436
Query: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 437 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 474
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 93.6 bits (231), Expect = 1e-19
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
R G+ D AL F +L FE D T EQ E L+ +Q S D C +++
Sbjct: 277 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD---CFICCILS 333
Query: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDE- 147
HG +G + G DG+ + L C +L KPKV+ IQAC+G+ G V D
Sbjct: 334 HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSE 393
Query: 148 ---IVMVIKDSPQT--IPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RK 199
+ + SPQT IP D L +TV ++YR+ +G+ +IQ+L + R
Sbjct: 394 EQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRG 453
Query: 200 GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
IL +LTEV ++ + + K P+ TLRK+L
Sbjct: 454 DDILTILTEVNYEVSNKD--DKKNMGKQMPQPTFTLRKKL 491
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 85.5 bits (210), Expect = 4e-17
Identities = 50/182 (27%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
K R+G+ +D + L H+F+ L F + + T + + L+K Q + C +
Sbjct: 298 KDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNPAHADGDCFVFCI 355
Query: 87 MAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGD 146
+ HGR G + D ++ + + C L KPK++ IQAC+GE+ P ++ D
Sbjct: 356 LTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEAD 415
Query: 147 EI--VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILE 204
+ +IP D L +TV GY+++RH ++GS +IQ+L + K +L+
Sbjct: 416 ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLK 475
Query: 205 LL 206
L
Sbjct: 476 FL 477
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 85.5 bits (210), Expect = 4e-17
Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 35/244 (14%)
Query: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
+ R GS D + L F L F +K D TA++ L + Q D C VV+
Sbjct: 178 RTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALD---CCVVVI 234
Query: 87 MAHGRE-------GFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDP 139
++HG + G + G DG V +E + N +C +L KPK++ IQAC GEQ+D
Sbjct: 235 LSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDH 294
Query: 140 GETVGG----DEI-----------------VMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
G V DE D+ ++PT +D YST G++++
Sbjct: 295 GFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSW 354
Query: 179 RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKR 238
R + GS +++TL D+F ++ H E L + R+A A V+ K P + LRK+
Sbjct: 355 RDPKSGSWYVETLDDIF-EQWAH-SEDLQSLLLRVANAVSVK--GIYKQMPGCFNFLRKK 410
Query: 239 LYLQ 242
L+ +
Sbjct: 411 LFFK 414
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 82.4 bits (202), Expect = 3e-16
Identities = 74/257 (28%), Positives = 107/257 (41%), Gaps = 30/257 (11%)
Query: 10 EKYDMSGARLALILCVTKAR----------EGSEEDLDALEHMFRQLRFESTMKRDPTAE 59
EKY M R + L R G+ D D L F L FE D AE
Sbjct: 35 EKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAE 94
Query: 60 QFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQA 119
+ L K + C V ++HG + D + ++++ L C +
Sbjct: 95 EL---LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHS 150
Query: 120 LRAKPKVYIIQACRGEQRD----PGETVGGD------EIVMVIKDSPQTIPTYTDALHVY 169
L KPK++IIQACRG Q D P + V I V S T+P D L Y
Sbjct: 151 LVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCY 210
Query: 170 STVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHI--LELLTEVTRRMAE--AELVQEGKA- 224
S EGY ++R GS +IQ L ++ K + ELLT V R++++ + ++ A
Sbjct: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
Query: 225 -RKTNPEIQSTLRKRLY 240
+K P S L K+L+
Sbjct: 271 GKKQVPCFASMLTKKLH 287
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 80.9 bits (198), Expect = 9e-16
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 206 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 265
Query: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 266 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 323
Query: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 324 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 383
Query: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 384 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 438
Query: 237 KRLYL 241
+ YL
Sbjct: 439 RDFYL 443
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 80.9 bits (198), Expect = 9e-16
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 51 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 110
Query: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 111 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 168
Query: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 169 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 228
Query: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 229 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 283
Query: 237 KRLYL 241
+ YL
Sbjct: 284 RDFYL 288
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 80.9 bits (198), Expect = 9e-16
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 135 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 194
Query: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 195 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 252
Query: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 253 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 312
Query: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 313 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 367
Query: 237 KRLYL 241
+ YL
Sbjct: 368 RDFYL 372
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 80.9 bits (198), Expect = 9e-16
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 193 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 252
Query: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 253 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 310
Query: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 311 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 370
Query: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 371 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 425
Query: 237 KRLYL 241
+ YL
Sbjct: 426 RDFYL 430
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 79.7 bits (195), Expect = 2e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 67 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 126
Query: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 127 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184
Query: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 185 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 242
Query: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 243 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 295
Query: 229 PEIQSTLRKRLYL 241
E + TL + YL
Sbjct: 296 TE-RVTLTRCFYL 307
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 79.7 bits (195), Expect = 2e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 160 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 219
Query: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 220 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 277
Query: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 278 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 335
Query: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 336 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 388
Query: 229 PEIQSTLRKRLYL 241
E + TL + YL
Sbjct: 389 TE-RVTLTRCFYL 400
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 79.7 bits (195), Expect = 2e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 139 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 198
Query: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 199 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 256
Query: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 257 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 314
Query: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 315 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 367
Query: 229 PEIQSTLRKRLYL 241
E + TL + YL
Sbjct: 368 TE-RVTLTRCFYL 379
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 74.3 bits (181), Expect = 9e-14
Identities = 48/131 (36%), Positives = 69/131 (52%), Gaps = 12/131 (9%)
Query: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 67 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 126
Query: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 127 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 184
Query: 125 KVYIIQACRGE 135
KV IIQACRG+
Sbjct: 185 KVIIIQACRGD 195
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 72.0 bits (175), Expect = 4e-13
Identities = 54/176 (30%), Positives = 83/176 (47%), Gaps = 17/176 (9%)
Query: 81 CAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRD-- 138
C V ++HG + D + ++++ L C +L KPK++IIQACRG Q D
Sbjct: 24 CFVCVFLSHGEGNHIYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVP 82
Query: 139 --PGETVGGD------EIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQT 190
P + V I V S T+P D L YS EGY ++R GS +IQ
Sbjct: 83 VIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQD 142
Query: 191 LVDVFTKRKGHI--LELLTEVTRRMAE--AELVQEGKA--RKTNPEIQSTLRKRLY 240
L ++ K + ELLT V R++++ + ++ A +K P S L K+L+
Sbjct: 143 LCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLH 198
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 71.6 bits (174), Expect = 6e-13
Identities = 67/251 (26%), Positives = 112/251 (44%), Gaps = 49/251 (19%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C T+ R G++ D+ ++ + L + ++ + TA + L F
Sbjct: 80 RLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139
Query: 73 DSREDPVSCAFVVLMAHGREGFLKGEDG--------EMVKLENLFEALNNKNCQALRAKP 124
+ + F+VLM+HG L+G G +++ + +F+ NN+NC +L+ KP
Sbjct: 140 EHKSS--DSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194
Query: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT---------DALHVYSTVEGY 175
KV I+QACRG R GE + ++DSP ++ + DA++ + +
Sbjct: 195 KVIIVQACRGANR--GE--------LWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 244
Query: 176 IAY----------RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKAR 225
IA+ R GS FI L+ F K L EV R++ ++ KA+
Sbjct: 245 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCC--HLEEVFRKVQQSFETPRAKAQ 302
Query: 226 KTNPEIQSTLR 236
E S R
Sbjct: 303 MPTIERLSMTR 313
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 71.6 bits (174), Expect = 6e-13
Identities = 67/251 (26%), Positives = 112/251 (44%), Gaps = 49/251 (19%)
Query: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
RLALI+C T+ R G++ D+ ++ + L + ++ + TA + L F
Sbjct: 136 RLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195
Query: 73 DSREDPVSCAFVVLMAHGREGFLKGEDG--------EMVKLENLFEALNNKNCQALRAKP 124
+ + F+VLM+HG L+G G +++ + +F+ NN+NC +L+ KP
Sbjct: 196 EHKSS--DSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250
Query: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT---------DALHVYSTVEGY 175
KV I+QACRG R GE + ++DSP ++ + DA++ + +
Sbjct: 251 KVIIVQACRGANR--GE--------LWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
Query: 176 IAY----------RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKAR 225
IA+ R GS FI L+ F K L EV R++ ++ KA+
Sbjct: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCC--HLEEVFRKVQQSFETPRAKAQ 358
Query: 226 KTNPEIQSTLR 236
E S R
Sbjct: 359 MPTIERLSMTR 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,771,427
Number of Sequences: 37866
Number of extensions: 363124
Number of successful extensions: 1253
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1150
Number of HSP's gapped (non-prelim): 70
length of query: 242
length of database: 18,247,518
effective HSP length: 99
effective length of query: 143
effective length of database: 14,498,784
effective search space: 2073326112
effective search space used: 2073326112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.