BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3 [Homo sapiens] (633 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3... 1294 0.0 gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2... 1219 0.0 gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1... 900 0.0 gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap... 213 3e-55 gi|216547519 interleukin-1 receptor-associated kinase 3 isoform ... 171 2e-42 gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 170 3e-42 gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 170 3e-42 gi|216547504 interleukin-1 receptor-associated kinase 3 isoform ... 168 1e-41 gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 164 2e-40 gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 164 2e-40 gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 164 2e-40 gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 99 1e-20 gi|155723000 mixed lineage kinase 4 [Homo sapiens] 99 2e-20 gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 95 2e-19 gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 92 2e-18 gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 92 2e-18 gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 90 7e-18 gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 89 1e-17 gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 89 2e-17 gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 88 3e-17 gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 87 5e-17 gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 86 1e-16 gi|33188459 B-Raf [Homo sapiens] 86 1e-16 gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 86 1e-16 gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 84 4e-16 gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 82 2e-15 gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 82 2e-15 gi|38327632 discoidin domain receptor family, member 1 isoform b... 80 7e-15 gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 77 5e-14 gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 76 8e-14 >gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3 [Homo sapiens] Length = 633 Score = 1294 bits (3348), Expect = 0.0 Identities = 633/633 (100%), Positives = 633/633 (100%) Query: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE Sbjct: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 Query: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS Sbjct: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 Query: 421 QRAVKTHGARTKYLVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAA 480 QRAVKTHGARTKYLVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAA Sbjct: 421 QRAVKTHGARTKYLVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAA 480 Query: 481 PWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAG 540 PWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAG Sbjct: 481 PWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAG 540 Query: 541 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG 600 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG Sbjct: 541 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG 600 Query: 601 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 633 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS Sbjct: 601 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 633 >gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2 [Homo sapiens] Length = 682 Score = 1219 bits (3155), Expect = 0.0 Identities = 616/682 (90%), Positives = 619/682 (90%), Gaps = 49/682 (7%) Query: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE Sbjct: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 Query: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS Sbjct: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 Query: 421 QRAVKTHGARTKY---LVYERLEK-----------LQAVVAGVP---------------- 450 QRAVKTHGARTKY LV E E+ LQA +A Sbjct: 421 QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP 480 Query: 451 -----------GHSEAASCI--------PPSPQENSYVSSTGRAHSGAAPWQPLAAPSGA 491 G + A C PP QENSYVSSTGRAHSGAAPWQPLAAPSGA Sbjct: 481 RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQENSYVSSTGRAHSGAAPWQPLAAPSGA 540 Query: 492 SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESS 551 SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESS Sbjct: 541 SAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESS 600 Query: 552 WGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSS 611 WGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSS Sbjct: 601 WGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSS 660 Query: 612 SLPGLGLEQDRQGPEESDEFQS 633 SLPGLGLEQDRQGPEESDEFQS Sbjct: 661 SLPGLGLEQDRQGPEESDEFQS 682 >gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1 [Homo sapiens] Length = 712 Score = 900 bits (2325), Expect = 0.0 Identities = 439/449 (97%), Positives = 442/449 (98%), Gaps = 2/449 (0%) Query: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE Sbjct: 1 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60 Query: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS Sbjct: 61 RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120 Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180 Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360 Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420 Query: 421 QRAVKTHGARTKYLVYERLEKLQAVVAGV 449 QRAVKTHGARTKYL + L + +A AGV Sbjct: 421 QRAVKTHGARTKYL--KDLVEEEAEEAGV 447 Score = 399 bits (1025), Expect = e-111 Identities = 199/199 (100%), Positives = 199/199 (100%) Query: 435 VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ 494 VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ Sbjct: 514 VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ 573 Query: 495 AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS 554 AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS Sbjct: 574 AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS 633 Query: 555 GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP 614 GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP Sbjct: 634 GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP 693 Query: 615 GLGLEQDRQGPEESDEFQS 633 GLGLEQDRQGPEESDEFQS Sbjct: 694 GLGLEQDRQGPEESDEFQS 712 >gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sapiens] Length = 625 Score = 213 bits (543), Expect = 3e-55 Identities = 180/654 (27%), Positives = 281/654 (42%), Gaps = 99/654 (15%) Query: 18 FLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQR------TASVLW 71 ++Y++P WV+ + MDAL DW +FA+ ++ D T+LR +S +R T +LW Sbjct: 4 YIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKI-KSMERVQGVSITRELLW 62 Query: 72 PWINRNARVADLVHILTHLQLLRARDIITAWHPP----APLPS-PGTTAPRPSSIPAPAE 126 W R A V LV +L L+L RA II W P P+P+ P + P + + Sbjct: 63 WWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRK 122 Query: 127 AEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESS 186 AE P +TF P ++ H PA L PP S P SS Sbjct: 123 AEDEQEEGQPVRMATFPGPGSSPARAHQ---------PAFLQPPEEDAPHSLRSDLPTSS 173 Query: 187 VS------------LLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 234 S LL A F W ++ + T +F++ KI +G F VYR Sbjct: 174 DSKDFSTSIPKQEKLLSLAGDSLF-WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGK 232 Query: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294 + K+L+E A ++++ F E++ R HPN++ G+CA F+ +Y ++ NG Sbjct: 233 PFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG 292 Query: 295 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP 354 SL+DRL Q PL WPQR+ I G A+++LH +IH ++KSSNVLLD+ LTP Sbjct: 293 SLQDRLQGQ-GGSDPLPWPQRVSICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTP 349 Query: 355 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 414 KL + + + +T +R + AYLPE++I+ G+L D FS G+V+ Sbjct: 350 KLAH----PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405 Query: 415 LETLAG-----------------------------QRAVKTHGARTKYLVYERLEKLQAV 445 E L G R K + + LEK Sbjct: 406 AEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGR 465 Query: 446 VAGVPGHSEA-ASCIPPSPQENSYVSSTG---------RAHSGAAPWQPLAAPSGASAQA 495 + + A A+C+ + S G R PW L+ +G+S+ Sbjct: 466 LPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNT 525 Query: 496 AEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLD--PAPLREAGCPQGDTAGESSWG 553 E+ N +++ S +S A + TP P + LR + D++ E+ G Sbjct: 526 PEETDDVDNSSLDASSS---MSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVG 582 Query: 554 SGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQL 607 P T QI IN A++K+++ + LY++ +DS++L Sbjct: 583 LEPPQDVTETSW--------------QIEINEAKRKLMENILLYKEEKVDSIEL 622 >gi|216547519 interleukin-1 receptor-associated kinase 3 isoform a [Homo sapiens] Length = 596 Score = 171 bits (432), Expect = 2e-42 Identities = 128/423 (30%), Positives = 195/423 (46%), Gaps = 60/423 (14%) Query: 8 GEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLCERSGQR- 65 G A A L+++PP ++ V+D+ + A W A + ++R E+ + Sbjct: 6 GARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQG 65 Query: 66 ---TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIP 122 T +LW W +N + DL LQ+L+ A H Sbjct: 66 KSGTRELLWSWAQKNKTIGDL------LQVLQEMGHRRAIH------------------- 100 Query: 123 APAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPG 182 L ++ LSP+ Q P + L A++ + P Sbjct: 101 ------------LITNYGAVLSPSEKSYQEGGFPNI-LFKETANV------TVDNVLIPE 141 Query: 183 PESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK 242 LL+ + F I GT NF ++ IGEG VYR ++N YAVK K Sbjct: 142 HNEKGILLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFK 195 Query: 243 ENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC 302 + ++ + FL+E+E L F HPNI++ A Y + +CL+Y ++ NG+L DRL C Sbjct: 196 QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQC 255 Query: 303 QTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGL 361 PL W R+ IL+G ++AI +LH P S+I G I S+N+LLD++ PKL DF + Sbjct: 256 VGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314 Query: 362 ARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421 A F QS + T + L Y+PEEYI+ G+L++ TD +SFG+V++E L G Sbjct: 315 A---HFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371 Query: 422 RAV 424 R V Sbjct: 372 RVV 374 >gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 170 bits (431), Expect = 3e-42 Identities = 128/416 (30%), Positives = 192/416 (46%), Gaps = 66/416 (15%) Query: 32 KVMDALEPAD-WCQFAALIVRDQTELR-----------LCERSGQRTASVLWPWINRNAR 79 K+ D ++P + W + A I + + R L + T+ +L+ W N Sbjct: 21 KLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCT 80 Query: 80 VADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLP--S 137 V DLV +L I + PA L P +++P+ EA +++P Sbjct: 81 VGDLVDLL----------IQNEFFAPASLLLPDAVPKTANTLPSK-EAITVQQKQMPFCD 129 Query: 138 SASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197 T ++P Q++ P+ PE+ + R Sbjct: 130 KDRTLMTPVQNLEQSYMPPD----------------------SSSPENKSLEVSDTRFHS 167 Query: 198 FCWPLCEISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTA 251 F + E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ Sbjct: 168 FSF--YELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEE 225 Query: 252 VKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS 311 +KQ F E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLS Sbjct: 226 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLS 284 Query: 312 WPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSS 371 W R I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S Sbjct: 285 WHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS------ 336 Query: 372 PSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427 + + T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H Sbjct: 337 -EKFAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 390 >gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 170 bits (431), Expect = 3e-42 Identities = 128/416 (30%), Positives = 192/416 (46%), Gaps = 66/416 (15%) Query: 32 KVMDALEPAD-WCQFAALIVRDQTELR-----------LCERSGQRTASVLWPWINRNAR 79 K+ D ++P + W + A I + + R L + T+ +L+ W N Sbjct: 21 KLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCT 80 Query: 80 VADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLP--S 137 V DLV +L I + PA L P +++P+ EA +++P Sbjct: 81 VGDLVDLL----------IQNEFFAPASLLLPDAVPKTANTLPSK-EAITVQQKQMPFCD 129 Query: 138 SASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197 T ++P Q++ P+ PE+ + R Sbjct: 130 KDRTLMTPVQNLEQSYMPPD----------------------SSSPENKSLEVSDTRFHS 167 Query: 198 FCWPLCEISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTA 251 F + E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ Sbjct: 168 FSF--YELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEE 225 Query: 252 VKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS 311 +KQ F E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLS Sbjct: 226 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLS 284 Query: 312 WPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSS 371 W R I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S Sbjct: 285 WHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS------ 336 Query: 372 PSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427 + + T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H Sbjct: 337 -EKFAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 390 >gi|216547504 interleukin-1 receptor-associated kinase 3 isoform b [Homo sapiens] Length = 535 Score = 168 bits (426), Expect = 1e-41 Identities = 91/221 (41%), Positives = 131/221 (59%), Gaps = 5/221 (2%) Query: 205 ISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLS 264 I GT NF ++ IGEG VYR ++N YAVK K+ ++ + FL+E+E L Sbjct: 97 IIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLL 156 Query: 265 RFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTAR 324 F HPNI++ A Y + +CL+Y ++ NG+L DRL C PL W R+ IL+G ++ Sbjct: 157 LFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTA-PLPWHIRIGILIGISK 215 Query: 325 AIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQT 383 AI +LH P S+I G I S+N+LLD++ PKL DF +A F QS + T + Sbjct: 216 AIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMA---HFRSHLEHQSCTINMTSS 272 Query: 384 VRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAV 424 L Y+PEEYI+ G+L++ TD +SFG+V++E L G R V Sbjct: 273 SSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVV 313 >gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 164 bits (415), Expect = 2e-40 Identities = 94/230 (40%), Positives = 130/230 (56%), Gaps = 17/230 (7%) Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257 E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F Sbjct: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107 Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317 E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166 Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377 I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + + Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS-------EKFAQ 217 Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427 T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 266 >gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 164 bits (415), Expect = 2e-40 Identities = 94/230 (40%), Positives = 130/230 (56%), Gaps = 17/230 (7%) Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257 E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F Sbjct: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107 Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317 E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166 Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377 I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + + Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS-------EKFAQ 217 Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427 T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 266 >gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 164 bits (415), Expect = 2e-40 Identities = 94/230 (40%), Positives = 130/230 (56%), Gaps = 17/230 (7%) Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257 E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F Sbjct: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107 Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317 E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166 Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377 I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + + Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS-------EKFAQ 217 Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427 T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 266 >gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo sapiens] Length = 540 Score = 99.0 bits (245), Expect = 1e-20 Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 9/186 (4%) Query: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296 AVK L + L + ++ L E E L + R I+ G C + F +V ++PNGSL Sbjct: 45 AVKHLHIHTPL-LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSL 103 Query: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356 + LH +T+ P ++WP R IL A + +LH +P L+H D+K+ N+LLD K+ Sbjct: 104 NELLHRKTEY-PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162 Query: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG---RLAVDTDTFSFGVV 413 DFGL+++ R S S+SS ++ GT+ Y+P E + G R ++ D +S+ V+ Sbjct: 163 ADFGLSKW-RMMSLSQSRSS---KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218 Query: 414 VLETLA 419 E L+ Sbjct: 219 TWEVLS 224 >gi|155723000 mixed lineage kinase 4 [Homo sapiens] Length = 1036 Score = 98.6 bits (244), Expect = 2e-20 Identities = 73/228 (32%), Positives = 113/228 (49%), Gaps = 32/228 (14%) Query: 215 ELK--IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV 272 ELK IG GGFG VYRA + AVK +++ + + A +S E + RHPNI+ Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNII 184 Query: 273 DFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS-WPQR---------LDILLGT 322 + G C Q CLV F G+L L A P + P+R ++ + Sbjct: 185 ELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQI 244 Query: 323 ARAIQFLHQDS-PSLIHGDIKSSNVLLDERL--------TPKLGDFGLARFSRFAGSSPS 373 AR + +LH+++ ++H D+KSSN+LL E++ T K+ DFGLAR Sbjct: 245 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR---------- 294 Query: 374 QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421 + + T GT A++ E IK+ + +D +S+GV++ E L G+ Sbjct: 295 EWHRTTKMSTA-GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGE 341 >gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens] Length = 648 Score = 95.1 bits (235), Expect = 2e-19 Identities = 86/288 (29%), Positives = 135/288 (46%), Gaps = 41/288 (14%) Query: 150 SQTHSGPELGLVPSPASL----WPPPPSPAPSSTKPGPESSVSLL-----QGARPFPFCW 200 S + S L SP +L W P +P P+ + P S +G R + W Sbjct: 283 SHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYW 342 Query: 201 PL--CEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK-QSFL 257 + E+ T +IG G FG VY+ V AVK LK ++ T + Q+F Sbjct: 343 EIEASEVMLST-------RIGSGSFGTVYKGKWHGDV-AVKILKV---VDPTPEQFQAFR 391 Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317 EV L + RH NI+ F GY ++ +V + SL LH Q Q +D Sbjct: 392 NEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMF---QLID 447 Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSS 376 I TA+ + +LH + ++IH D+KS+N+ L E LT K+GDFGLA SR++GS Sbjct: 448 IARQTAQGMDYLH--AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ----- 500 Query: 377 MVARTQTVRGTLAYLPEEYIK---TGRLAVDTDTFSFGVVVLETLAGQ 421 + + G++ ++ E I+ + +D +S+G+V+ E + G+ Sbjct: 501 ---QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 545 >gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] Length = 835 Score = 91.7 bits (226), Expect = 2e-18 Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 21/254 (8%) Query: 169 PPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYR 228 P P S TK ++ + LL+ P F L EI F E IG G FG VY+ Sbjct: 429 PSPLGKIKSMTKE--KADILLLRAGLPSHFHLQLSEIE-----FHEI--IGSGSFGKVYK 479 Query: 229 AVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQN-GFYCLV 287 RN + A+KR + N + V F EV L + HP ++ F G C + + +V Sbjct: 480 GRCRNKIVAIKRYRANTYCSKSDVDM-FCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 538 Query: 288 YGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL 347 ++ GSL LH Q + L +L I + A+ +++LH + +IH D+ S N+L Sbjct: 539 TQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 595 Query: 348 LDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDT 407 L E + DFG +RF + S + +M + +R PE + + R + D Sbjct: 596 LYEDGHAVVADFGESRFLQ----SLDEDNMTKQPGNLRW---MAPEVFTQCTRYTIKADV 648 Query: 408 FSFGVVVLETLAGQ 421 FS+ + + E L G+ Sbjct: 649 FSYALCLWEILTGE 662 >gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] Length = 936 Score = 91.7 bits (226), Expect = 2e-18 Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 21/254 (8%) Query: 169 PPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYR 228 P P S TK ++ + LL+ P F L EI F E IG G FG VY+ Sbjct: 530 PSPLGKIKSMTKE--KADILLLRAGLPSHFHLQLSEIE-----FHEI--IGSGSFGKVYK 580 Query: 229 AVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQN-GFYCLV 287 RN + A+KR + N + V F EV L + HP ++ F G C + + +V Sbjct: 581 GRCRNKIVAIKRYRANTYCSKSDVDM-FCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 639 Query: 288 YGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL 347 ++ GSL LH Q + L +L I + A+ +++LH + +IH D+ S N+L Sbjct: 640 TQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 696 Query: 348 LDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDT 407 L E + DFG +RF + S + +M + +R PE + + R + D Sbjct: 697 LYEDGHAVVADFGESRFLQ----SLDEDNMTKQPGNLRW---MAPEVFTQCTRYTIKADV 749 Query: 408 FSFGVVVLETLAGQ 421 FS+ + + E L G+ Sbjct: 750 FSYALCLWEILTGE 763 >gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo sapiens] Length = 847 Score = 89.7 bits (221), Expect = 7e-18 Identities = 72/233 (30%), Positives = 109/233 (46%), Gaps = 32/233 (13%) Query: 201 PLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEV 260 P CE++ EE+ IG GGFG VYR R + AVK +++ D + + +S E Sbjct: 107 PPCEVASFQELRLEEV-IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEA 165 Query: 261 EQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLD 317 + HPNI+ C + CLV + G L L + PP ++W ++ Sbjct: 166 RLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL--AGRRVPPHVLVNWAVQI- 222 Query: 318 ILLGTARAIQFLHQDS-PSLIHGDIKSSNVLL--------DERLTPKLGDFGLARFSRFA 368 AR + +LH ++ +IH D+KS+N+LL E T K+ DFGLAR Sbjct: 223 -----ARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----E 273 Query: 369 GSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421 +Q S GT A++ E IK + +D +SFGV++ E L G+ Sbjct: 274 WHKTTQMS-------AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGE 319 Score = 35.8 bits (81), Expect = 0.12 Identities = 28/95 (29%), Positives = 39/95 (41%), Gaps = 4/95 (4%) Query: 104 PPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFP-GSQTHSGPELGLVP 162 PP P P+P T P PS + + SP P+ A L P G ++ P P Sbjct: 678 PPTPTPAPCPTEPPPSPLICFSLKTPDSP---PTPAPLLLDLGIPVGQRSAKSPRREEEP 734 Query: 163 SPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197 ++ PPP + + PG S L +RP P Sbjct: 735 RGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRP 769 >gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo sapiens] Length = 606 Score = 89.0 bits (219), Expect = 1e-17 Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 21/222 (9%) Query: 217 KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG 276 +IG G FG V+R V AVK LK + A Q+F E++ L + RH NI+ F G Sbjct: 315 RIGTGSFGTVFRGRWHGDV-AVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMG 371 Query: 277 YCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSL 336 + + GF ++ + SL LH A Q +D+ TA+ + +LH + ++ Sbjct: 372 FMTRPGF-AIITQWCEGSSLYHHLHV---ADTRFDMVQLIDVARQTAQGMDYLH--AKNI 425 Query: 337 IHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395 IH D+KS+N+ L E LT K+GDFGLA +R++G+ P + G++ ++ E Sbjct: 426 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP--------SGSVLWMAAEV 477 Query: 396 IK---TGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYL 434 I+ + +D +++GVV+ E + G G R + + Sbjct: 478 IRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQII 519 >gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo sapiens] Length = 954 Score = 88.6 bits (218), Expect = 2e-17 Identities = 72/253 (28%), Positives = 110/253 (43%), Gaps = 42/253 (16%) Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240 PG ++ + LQ + PF H E IG GGFG VYRA+ R AVK Sbjct: 78 PGAPAAPAGLQLPQEIPF-----------HELQLEEIIGVGGFGKVYRALWRGEEVAVKA 126 Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300 + + + + + E +HPNI+ G C CLV + G+L L Sbjct: 127 ARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL 186 Query: 301 HCQTQACPP---LSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERL---- 352 + PP ++W ++ AR + +LH D+P +IH D+KS N+L+ E + Sbjct: 187 --AGRRVPPHVLVNWAVQV------ARGMNYLHNDAPVPIIHRDLKSINILILEAIENHN 238 Query: 353 ----TPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTF 408 K+ DFGLAR + GT A++ E I+ + +D + Sbjct: 239 LADTVLKITDFGLAR-----------EWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVW 287 Query: 409 SFGVVVLETLAGQ 421 SFGV++ E L G+ Sbjct: 288 SFGVLLWELLTGE 300 Score = 30.0 bits (66), Expect = 6.8 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 9/95 (9%) Query: 92 LLRARDIITAWHPPAPLPSPGTTAPRPSSIPAP---AEAEAWSPRKLPSSASTFLSPAFP 148 LLR+ A P+P PSP P PS P E E++ S T ++ A Sbjct: 761 LLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACA 820 Query: 149 GSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGP 183 S+ H PS +L P P P+ PGP Sbjct: 821 VSRGHR-----RTPSDGALGQRGP-PEPAGHGPGP 849 >gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo sapiens] Length = 966 Score = 87.8 bits (216), Expect = 3e-17 Identities = 59/209 (28%), Positives = 99/209 (47%), Gaps = 27/209 (12%) Query: 213 SEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV 272 SE +G G G V+ R A+K+++E + T+++ L + +HPNI+ Sbjct: 169 SELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----------TDIKHLRKLKHPNII 217 Query: 273 DFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD 332 F G C Q YC++ + +G L + L + P L +D G A + +LH Sbjct: 218 AFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL----LVDWSTGIASGMNYLHLH 273 Query: 333 SPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLP 392 +IH D+KS NVL+ K+ DFG ++ + S + + GT+A++ Sbjct: 274 --KIIHRDLKSPNVLVTHTDAVKISDFGTSK----------ELSDKSTKMSFAGTVAWMA 321 Query: 393 EEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421 E I+ ++ D +SFGVV+ E L G+ Sbjct: 322 PEVIRNEPVSEKVDIWSFGVVLWELLTGE 350 >gi|66932999 testis-specific protein kinase 1 [Homo sapiens] Length = 626 Score = 87.0 bits (214), Expect = 5e-17 Identities = 82/285 (28%), Positives = 123/285 (43%), Gaps = 38/285 (13%) Query: 155 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE 214 GP G VP PP P G SS L+ A + ++R +F Sbjct: 12 GPGPGEVPGEG---PPGPGGTGGGPGRGRPSSYRALRSA--------VSSLAR-VDDFHC 59 Query: 215 ELKIGEGGFGCVYRAVMRNT----VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPN 270 KIG G F VY+ R + V + +L N + + L EV+ ++R RHPN Sbjct: 60 AEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN--------RGNTLREVQLMNRLRHPN 111 Query: 271 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 330 I+ F G C G + ++ G+LE L + PLSWP RL + L AR +++LH Sbjct: 112 ILRFMGVCVHQGQLHALTEYMNGGTLEQLL----SSPEPLSWPVRLHLALDIARGLRYLH 167 Query: 331 QDSPSLIHGDIKSSNVLL---DERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGT 387 S + H D+ S N L+ D T +GDFGLA + + V G+ Sbjct: 168 --SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPL-----AVVGS 220 Query: 388 LAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTK 432 ++ E ++ D F+FG+V+ E +A A + RT+ Sbjct: 221 PYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTE 265 >gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo sapiens] Length = 518 Score = 85.9 bits (211), Expect = 1e-16 Identities = 71/206 (34%), Positives = 99/206 (48%), Gaps = 16/206 (7%) Query: 218 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 277 +G+GGFG V+RA R Y V N+ VK + E + R +++ + Sbjct: 27 VGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLE--GVIEKVNW 84 Query: 278 CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLI 337 Q+ LV F+ NGSL L Q P WP +L + +LH +P L+ Sbjct: 85 -DQDPKPALVTKFMENGSLSGLLQSQC----PRPWPLLCRLLKEVVLGMFYLHDQNPVLL 139 Query: 338 HGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PEEYI 396 H D+K SNVLLD L KL DFGL S F G S S + + GTL YL PE ++ Sbjct: 140 HRDLKPSNVLLDPELHVKLADFGL---STFQGGSQSGTG----SGEPGGTLGYLAPELFV 192 Query: 397 KTGRLA-VDTDTFSFGVVVLETLAGQ 421 R A +D +SFG+++ LAG+ Sbjct: 193 NVNRKASTASDVYSFGILMWAVLAGR 218 >gi|33188459 B-Raf [Homo sapiens] Length = 766 Score = 85.5 bits (210), Expect = 1e-16 Identities = 68/209 (32%), Positives = 105/209 (50%), Gaps = 21/209 (10%) Query: 217 KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG 276 +IG G FG VY+ V AVK L A Q+F EV L + RH NI+ F G Sbjct: 462 RIGSGSFGTVYKGKWHGDV-AVKMLNVTAPTPQQL--QAFKNEVGVLRKTRHVNILLFMG 518 Query: 277 YCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSL 336 Y + +V + SL LH + + +DI TA+ + +LH + S+ Sbjct: 519 YSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMI---KLIDIARQTAQGMDYLH--AKSI 572 Query: 337 IHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395 IH D+KS+N+ L E LT K+GDFGLA SR++GS + + + G++ ++ E Sbjct: 573 IHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSH--------QFEQLSGSILWMAPEV 624 Query: 396 IK---TGRLAVDTDTFSFGVVVLETLAGQ 421 I+ + +D ++FG+V+ E + GQ Sbjct: 625 IRMQDKNPYSFQSDVYAFGIVLYELMTGQ 653 >gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo sapiens] Length = 1118 Score = 85.5 bits (210), Expect = 1e-16 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 52/280 (18%) Query: 158 LGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE--- 214 +G+ PS + P S S +PG E P C+P ++ +F+E Sbjct: 103 VGIFPSN---YVTPRSAFSSRCQPGGED-----------PSCYPPIQLLE--IDFAELTL 146 Query: 215 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 274 E IG GGFG VYRA AVK + + D + + ++ E + + +HPNI+ Sbjct: 147 EEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIAL 206 Query: 275 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLDILLGTARAIQFLHQ 331 G C + CLV F G L L + PP ++W ++ AR + +LH Sbjct: 207 RGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQI------ARGMNYLHD 258 Query: 332 DS-PSLIHGDIKSSNVLLDERLTP--------KLGDFGLAR-FSRFAGSSPSQSSMVART 381 ++ +IH D+KSSN+L+ +++ K+ DFGLAR + R S + Sbjct: 259 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA-------- 310 Query: 382 QTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421 GT A++ E I+ + +D +S+GV++ E L G+ Sbjct: 311 ----GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGE 346 >gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo sapiens] Length = 859 Score = 84.0 bits (206), Expect = 4e-16 Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 27/204 (13%) Query: 218 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 277 +G G G V+ AVK++++ + T+++ L + +HPNI+ F G Sbjct: 131 VGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----------TDIKHLRKLKHPNIITFKGV 179 Query: 278 CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLI 337 C Q YC++ F G L + L P L +D +G A + +LH +I Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL----LVDWSMGIAGGMNYLHLH--KII 233 Query: 338 HGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIK 397 H D+KS N+L+ K+ DFG ++ + S + + GT+A++ E I+ Sbjct: 234 HRDLKSPNMLITYDDVVKISDFGTSK----------ELSDKSTKMSFAGTVAWMAPEVIR 283 Query: 398 TGRLAVDTDTFSFGVVVLETLAGQ 421 ++ D +SFGVV+ E L G+ Sbjct: 284 NEPVSEKVDIWSFGVVLWELLTGE 307 >gi|41327754 ankyrin repeat domain 3 [Homo sapiens] Length = 784 Score = 82.0 bits (201), Expect = 2e-15 Identities = 69/210 (32%), Positives = 102/210 (48%), Gaps = 19/210 (9%) Query: 217 KIGEGGFGCVY--RAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 274 K+G GGFG VY R V T A+K + ++ + L E +++ + I+ Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVD-DRERMELLEEAKKMEMAKFRYILPV 84 Query: 275 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 334 G C + LV ++ GSLE L A PL W R I+ TA + FLH +P Sbjct: 85 YGICREP--VGLVMEYMETGSLEKLL-----ASEPLPWDLRFRIIHETAVGMNFLHCMAP 137 Query: 335 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 394 L+H D+K +N+LLD K+ DFGLA+ + G S S + + GT+AYLP E Sbjct: 138 PLLHLDLKPANILLDAHYHVKISDFGLAKCN---GLSHSHDLSM---DGLFGTIAYLPPE 191 Query: 395 YIKTGRLAVDT--DTFSFGVVVLETLAGQR 422 I+ DT D +SF +V+ L ++ Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKK 221 >gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo sapiens] Length = 765 Score = 81.6 bits (200), Expect = 2e-15 Identities = 61/209 (29%), Positives = 95/209 (45%), Gaps = 16/209 (7%) Query: 218 IGEGGFGCVYRAVMRN--TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 275 + GGF V++A R T YA+K ++ + E ++ + + +IV Sbjct: 28 VASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIY 87 Query: 276 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 335 G C Q +V F+ NGSLE L + L W R I+ T+ A+ FLH P Sbjct: 88 GVCKQP--LGIVMEFMANGSLEKVLSTHS-----LCWKLRFRIIHETSLAMNFLHSIKPP 140 Query: 336 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395 L+H D+K N+LLD + K+ DFGL+++ S +RG L+Y+P E Sbjct: 141 LLHLDLKPGNILLDSNMHVKISDFGLSKW-----MEQSTRMQYIERSALRGMLSYIPPEM 195 Query: 396 IKTGRLAVDT--DTFSFGVVVLETLAGQR 422 A D +SF +V+ E L ++ Sbjct: 196 FLESNKAPGPKYDVYSFAIVIWELLTQKK 224 >gi|38327632 discoidin domain receptor family, member 1 isoform b [Homo sapiens] Length = 876 Score = 79.7 bits (195), Expect = 7e-15 Identities = 93/373 (24%), Positives = 142/373 (38%), Gaps = 81/373 (21%) Query: 97 DIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGP 156 D I + P P P PRP P P SA P P +SG Sbjct: 468 DTILINNRPGPREPPPYQEPRPRGNP-------------PHSA-----PCVPNGSAYSGD 509 Query: 157 ELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQG----------ARPFPFCW---PLC 203 + A L PPPP +S E+ + LQG A P P Sbjct: 510 YMEPEKPGAPLLPPPPQ---NSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRV 566 Query: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMRNT------------------VYAVKRLKENA 245 + R F E K+GEG FG V+ + + + AVK L+ +A Sbjct: 567 DFPRSRLRFKE--KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA 624 Query: 246 DLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC--- 302 + FL EV+ +SR + PNI+ G C Q+ C++ ++ NG L L Sbjct: 625 TKN---ARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 681 Query: 303 ------------QTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDE 350 Q P +S+P L + A +++L + + +H D+ + N L+ E Sbjct: 682 EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL--ATLNFVHRDLATRNCLVGE 739 Query: 351 RLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSF 410 T K+ DFG++R + +AG + ++ E I G+ +D ++F Sbjct: 740 NFTIKIADFGMSR-NLYAGDYYRVQGRAVL------PIRWMAWECILMGKFTTASDVWAF 792 Query: 411 GVVVLETLAGQRA 423 GV + E L RA Sbjct: 793 GVTLWEVLMLCRA 805 >gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] Length = 360 Score = 77.0 bits (188), Expect = 5e-14 Identities = 70/215 (32%), Positives = 96/215 (44%), Gaps = 16/215 (7%) Query: 207 RGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRF 266 R F + +IGEG +G VYRA T V K D E + S L E+ L R Sbjct: 34 RSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRL 93 Query: 267 RHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACP-PLSWPQRLDILLGTARA 325 RHPNIV+ N + FL G E L + P P S Q I+L R Sbjct: 94 RHPNIVELKEVVVGNHLESI---FLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRG 150 Query: 326 IQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVR 385 +Q+LH++ +IH D+K SN+L+ ++ K DFGLAR + P +V Sbjct: 151 LQYLHRN--FIIHRDLKVSNLLMTDKGCVKTADFGLAR-AYGVPVKPMTPKVV------- 200 Query: 386 GTLAY-LPEEYIKTGRLAVDTDTFSFGVVVLETLA 419 TL Y PE + T D ++ G ++ E LA Sbjct: 201 -TLWYRAPELLLGTTTQTTSIDMWAVGCILAELLA 234 >gi|21735566 mitogen-activated protein kinase kinase kinase 7 isoform D [Homo sapiens] Length = 491 Score = 76.3 bits (186), Expect = 8e-14 Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 23/207 (11%) Query: 218 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 277 +G G FG V +A R A+K+++ ++ +++F+ E+ QLSR HPNIV G Sbjct: 42 VGRGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQLSRVNHPNIVKLYGA 95 Query: 278 CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SL 336 C CLV + GSL + LH + P + + L ++ + +LH P +L Sbjct: 96 CLNP--VCLVMEYAEGGSLYNVLH-GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKAL 152 Query: 337 IHGDIKSSNVLLDERLTP-KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395 IH D+K N+LL T K+ DFG A + +G+ A++ E Sbjct: 153 IHRDLKPPNLLLVAGGTVLKICDFGTA------------CDIQTHMTNNKGSAAWMAPEV 200 Query: 396 IKTGRLAVDTDTFSFGVVVLETLAGQR 422 + + D FS+G+++ E + ++ Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRK 227 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,118,016 Number of Sequences: 37866 Number of extensions: 1769323 Number of successful extensions: 21936 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 589 Number of HSP's successfully gapped in prelim test: 1195 Number of HSP's that attempted gapping in prelim test: 13662 Number of HSP's gapped (non-prelim): 6831 length of query: 633 length of database: 18,247,518 effective HSP length: 108 effective length of query: 525 effective length of database: 14,157,990 effective search space: 7432944750 effective search space used: 7432944750 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.