Search of human proteins with 68800243

Search of human proteins with 68800243

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|68800243 interleukin-1 receptor-associated kinase 1 isoform
1 [Homo sapiens]
         (712 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1...  1456   0.0  
gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2...  1381   0.0  
gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3...   900   0.0  
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap...   240   3e-63
gi|216547519 interleukin-1 receptor-associated kinase 3 isoform ...   189   6e-48
gi|216547504 interleukin-1 receptor-associated kinase 3 isoform ...   187   3e-47
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ...   177   4e-44
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ...   177   4e-44
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ...   171   3e-42
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ...   171   3e-42
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ...   171   3e-42
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ...    99   1e-20
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                     99   2e-20
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom...    95   2e-19
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...    94   6e-19
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           92   2e-18
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]         92   2e-18
gi|38327632 discoidin domain receptor family, member 1 isoform b...    89   1e-17
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom...    89   1e-17
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...    89   2e-17
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...    88   3e-17
gi|66932999 testis-specific protein kinase 1 [Homo sapiens]            87   5e-17
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo...    86   1e-16
gi|33188459 B-Raf [Homo sapiens]                                       86   2e-16
gi|83977450 discoidin domain receptor family, member 1 isoform a...    86   2e-16
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...    86   2e-16
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...    85   3e-16
gi|83977452 discoidin domain receptor family, member 1 isoform c...    83   8e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     82   2e-15
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    82   2e-15

>gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1
           [Homo sapiens]
          Length = 712

 Score = 1456 bits (3770), Expect = 0.0
 Identities = 712/712 (100%), Positives = 712/712 (100%)

Query: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60
           MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
Sbjct: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60

Query: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120
           RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
Sbjct: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120

Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180
           IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180

Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240
           PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240

Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300
           LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300

Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360
           HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360

Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420
           LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420

Query: 421 QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP 480
           QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
Sbjct: 421 QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP 480

Query: 481 RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP 540
           RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
Sbjct: 481 RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP 540

Query: 541 SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR 600
           SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
Sbjct: 541 SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR 600

Query: 601 SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI 660
           SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
Sbjct: 601 SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI 660

Query: 661 IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 712
           IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Sbjct: 661 IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 712


>gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2
           [Homo sapiens]
          Length = 682

 Score = 1381 bits (3574), Expect = 0.0
 Identities = 682/712 (95%), Positives = 682/712 (95%), Gaps = 30/712 (4%)

Query: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60
           MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
Sbjct: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60

Query: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120
           RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
Sbjct: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120

Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180
           IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180

Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240
           PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240

Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300
           LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300

Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360
           HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360

Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420
           LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420

Query: 421 QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP 480
           QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
Sbjct: 421 QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP 480

Query: 481 RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP 540
           RPGPCPPELGLGLGQLACCCLHRRAKRRPPMT                            
Sbjct: 481 RPGPCPPELGLGLGQLACCCLHRRAKRRPPMT---------------------------- 512

Query: 541 SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR 600
             QENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
Sbjct: 513 --QENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR 570

Query: 601 SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI 660
           SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
Sbjct: 571 SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI 630

Query: 661 IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 712
           IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Sbjct: 631 IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 682


>gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3
           [Homo sapiens]
          Length = 633

 Score =  900 bits (2325), Expect = 0.0
 Identities = 439/449 (97%), Positives = 442/449 (98%), Gaps = 2/449 (0%)

Query: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60
           MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
Sbjct: 1   MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE 60

Query: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120
           RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
Sbjct: 61  RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS 120

Query: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180
           IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
Sbjct: 121 IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK 180

Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240
           PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
Sbjct: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240

Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300
           LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
Sbjct: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300

Query: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360
           HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
Sbjct: 301 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 360

Query: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420
           LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
Sbjct: 361 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 420

Query: 421 QRAVKTHGARTKYL--KDLVEEEAEEAGV 447
           QRAVKTHGARTKYL  + L + +A  AGV
Sbjct: 421 QRAVKTHGARTKYLVYERLEKLQAVVAGV 449



 Score =  399 bits (1025), Expect = e-111
 Identities = 199/199 (100%), Positives = 199/199 (100%)

Query: 514 VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ 573
           VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ
Sbjct: 435 VYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQ 494

Query: 574 AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS 633
           AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS
Sbjct: 495 AAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGS 554

Query: 634 GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP 693
           GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP
Sbjct: 555 GPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLP 614

Query: 694 GLGLEQDRQGPEESDEFQS 712
           GLGLEQDRQGPEESDEFQS
Sbjct: 615 GLGLEQDRQGPEESDEFQS 633


>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
           sapiens]
          Length = 625

 Score =  240 bits (613), Expect = 3e-63
 Identities = 196/694 (28%), Positives = 308/694 (44%), Gaps = 100/694 (14%)

Query: 18  FLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQR------TASVLW 71
           ++Y++P WV+    + MDAL   DW +FA+ ++ D T+LR   +S +R      T  +LW
Sbjct: 4   YIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKI-KSMERVQGVSITRELLW 62

Query: 72  PWINRNARVADLVHILTHLQLLRARDIITAWHPP----APLPS-PGTTAPRPSSIPAPAE 126
            W  R A V  LV +L  L+L RA  II  W P      P+P+ P +  P      +  +
Sbjct: 63  WWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRK 122

Query: 127 AEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESS 186
           AE       P   +TF  P    ++ H          PA L PP      S     P SS
Sbjct: 123 AEDEQEEGQPVRMATFPGPGSSPARAHQ---------PAFLQPPEEDAPHSLRSDLPTSS 173

Query: 187 VS------------LLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 234
            S            LL  A    F W   ++ + T +F++  KI +G F  VYR      
Sbjct: 174 DSKDFSTSIPKQEKLLSLAGDSLF-WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGK 232

Query: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294
            +  K+L+E A     ++++ F  E++   R  HPN++   G+CA   F+  +Y ++ NG
Sbjct: 233 PFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG 292

Query: 295 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP 354
           SL+DRL  Q  +  PL WPQR+ I  G   A+++LH     +IH ++KSSNVLLD+ LTP
Sbjct: 293 SLQDRLQGQGGS-DPLPWPQRVSICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTP 349

Query: 355 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 414
           KL        +     +      + +T  +R + AYLPE++I+ G+L    D FS G+V+
Sbjct: 350 KLAH----PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405

Query: 415 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY 474
            E L G  A+  + +   YLKDL+  +   +  +L S ++ ++  +A +         I 
Sbjct: 406 AEVLTGIPAMDNNRSPV-YLKDLLLSDIPSSTASLCSRKTGVENVMAKE---------IC 455

Query: 475 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEA 534
           +K+L+   G  P +    L   AC CL RR                LQ V   V    E 
Sbjct: 456 QKYLEKGAGRLPEDCAEALATAACLCLRRRNT-------------SLQEVCGSVAAVEER 502

Query: 535 ASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGG 594
                             R      PW  L+  +G+S+   E+     N  +++  S+  
Sbjct: 503 L-----------------RGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSM-- 543

Query: 595 LSAALRSWHLTPSCPLDPAP--LREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSAS 652
            S A  +   TP  P +     LR     + D++ E+  G  P    T            
Sbjct: 544 -SVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSW-------- 594

Query: 653 SSSEPPQIIINPARQKMVQKLALYEDGALDSLQL 686
                 QI IN A++K+++ + LY++  +DS++L
Sbjct: 595 ------QIEINEAKRKLMENILLYKEEKVDSIEL 622


>gi|216547519 interleukin-1 receptor-associated kinase 3 isoform a
           [Homo sapiens]
          Length = 596

 Score =  189 bits (481), Expect = 6e-48
 Identities = 156/522 (29%), Positives = 230/522 (44%), Gaps = 85/522 (16%)

Query: 8   GEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLCERSGQR- 65
           G   A  A   L+++PP ++     V+D+ + A  W   A  +     ++R  E+   + 
Sbjct: 6   GARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQG 65

Query: 66  ---TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIP 122
              T  +LW W  +N  + DL      LQ+L+      A H                   
Sbjct: 66  KSGTRELLWSWAQKNKTIGDL------LQVLQEMGHRRAIH------------------- 100

Query: 123 APAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPG 182
                       L ++    LSP+    Q    P + L    A++         +   P 
Sbjct: 101 ------------LITNYGAVLSPSEKSYQEGGFPNI-LFKETANV------TVDNVLIPE 141

Query: 183 PESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK 242
                 LL+ +  F        I  GT NF ++  IGEG    VYR  ++N  YAVK  K
Sbjct: 142 HNEKGILLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFK 195

Query: 243 ENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC 302
           +   ++     + FL+E+E L  F HPNI++ A Y  +   +CL+Y ++ NG+L DRL C
Sbjct: 196 QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQC 255

Query: 303 QTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGL 361
                 PL W  R+ IL+G ++AI +LH   P S+I G I S+N+LLD++  PKL DF +
Sbjct: 256 VGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314

Query: 362 ARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
           A    F      QS  +  T +    L Y+PEEYI+ G+L++ TD +SFG+V++E L G 
Sbjct: 315 A---HFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371

Query: 422 RAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPR 481
           R V       + L+DL+ E  E+ G+      S L                     LD +
Sbjct: 372 RVVLDDPKHIQ-LRDLLRELMEKRGL-----DSCL-------------------SFLDKK 406

Query: 482 PGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQA 523
             PCP      L  LA  C   RAK RP M +V   LE  QA
Sbjct: 407 VPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQA 448


>gi|216547504 interleukin-1 receptor-associated kinase 3 isoform b
           [Homo sapiens]
          Length = 535

 Score =  187 bits (475), Expect = 3e-47
 Identities = 119/320 (37%), Positives = 166/320 (51%), Gaps = 30/320 (9%)

Query: 205 ISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLS 264
           I  GT NF ++  IGEG    VYR  ++N  YAVK  K+   ++     + FL+E+E L 
Sbjct: 97  IIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLL 156

Query: 265 RFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTAR 324
            F HPNI++ A Y  +   +CL+Y ++ NG+L DRL C      PL W  R+ IL+G ++
Sbjct: 157 LFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTA-PLPWHIRIGILIGISK 215

Query: 325 AIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQT 383
           AI +LH   P S+I G I S+N+LLD++  PKL DF +A    F      QS  +  T +
Sbjct: 216 AIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMA---HFRSHLEHQSCTINMTSS 272

Query: 384 VRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAE 443
               L Y+PEEYI+ G+L++ TD +SFG+V++E L G R V       + L+DL+ E  E
Sbjct: 273 SSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQ-LRDLLRELME 331

Query: 444 EAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHR 503
           + G+      S L                     LD +  PCP      L  LA  C   
Sbjct: 332 KRGL-----DSCL-------------------SFLDKKVPPCPRNFSAKLFCLAGRCAAT 367

Query: 504 RAKRRPPMTQVYERLEKLQA 523
           RAK RP M +V   LE  QA
Sbjct: 368 RAKLRPSMDEVLNTLESTQA 387


>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
           [Homo sapiens]
          Length = 460

 Score =  177 bits (448), Expect = 4e-44
 Identities = 144/512 (28%), Positives = 227/512 (44%), Gaps = 93/512 (18%)

Query: 32  KVMDALEPAD-WCQFAALIVRDQTELR-----------LCERSGQRTASVLWPWINRNAR 79
           K+ D ++P + W + A  I +   + R           L +     T+ +L+ W   N  
Sbjct: 21  KLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCT 80

Query: 80  VADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLP--S 137
           V DLV +L          I   +  PA L  P       +++P+  EA     +++P   
Sbjct: 81  VGDLVDLL----------IQNEFFAPASLLLPDAVPKTANTLPSK-EAITVQQKQMPFCD 129

Query: 138 SASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197
              T ++P     Q++  P+                         PE+    +   R   
Sbjct: 130 KDRTLMTPVQNLEQSYMPPD----------------------SSSPENKSLEVSDTRFHS 167

Query: 198 FCWPLCEISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTA 251
           F +   E+   T+NF E        K+GEGGFG VY+  + NT  AVK+L    D+    
Sbjct: 168 FSF--YELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEE 225

Query: 252 VKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS 311
           +KQ F  E++ +++ +H N+V+  G+ +     CLVY ++PNGSL DRL C     PPLS
Sbjct: 226 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLS 284

Query: 312 WPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSS 371
           W  R  I  G A  I FLH++    IH DIKS+N+LLDE  T K+ DFGLAR S      
Sbjct: 285 WHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE----- 337

Query: 372 PSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGART 431
             + +    T  + GT AY+  E ++ G +   +D +SFGVV+LE + G  AV  H    
Sbjct: 338 --KFAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REP 393

Query: 432 KYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGL 491
           + L D+ EE  +E        + T++                   ++D +          
Sbjct: 394 QLLLDIKEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVE 427

Query: 492 GLGQLACCCLHRRAKRRPPMTQVYERLEKLQA 523
            +  +A  CLH +  +RP + +V + L+++ A
Sbjct: 428 AMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 459


>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
           [Homo sapiens]
          Length = 460

 Score =  177 bits (448), Expect = 4e-44
 Identities = 144/512 (28%), Positives = 227/512 (44%), Gaps = 93/512 (18%)

Query: 32  KVMDALEPAD-WCQFAALIVRDQTELR-----------LCERSGQRTASVLWPWINRNAR 79
           K+ D ++P + W + A  I +   + R           L +     T+ +L+ W   N  
Sbjct: 21  KLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCT 80

Query: 80  VADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLP--S 137
           V DLV +L          I   +  PA L  P       +++P+  EA     +++P   
Sbjct: 81  VGDLVDLL----------IQNEFFAPASLLLPDAVPKTANTLPSK-EAITVQQKQMPFCD 129

Query: 138 SASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197
              T ++P     Q++  P+                         PE+    +   R   
Sbjct: 130 KDRTLMTPVQNLEQSYMPPD----------------------SSSPENKSLEVSDTRFHS 167

Query: 198 FCWPLCEISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTA 251
           F +   E+   T+NF E        K+GEGGFG VY+  + NT  AVK+L    D+    
Sbjct: 168 FSF--YELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEE 225

Query: 252 VKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS 311
           +KQ F  E++ +++ +H N+V+  G+ +     CLVY ++PNGSL DRL C     PPLS
Sbjct: 226 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLS 284

Query: 312 WPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSS 371
           W  R  I  G A  I FLH++    IH DIKS+N+LLDE  T K+ DFGLAR S      
Sbjct: 285 WHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE----- 337

Query: 372 PSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGART 431
             + +    T  + GT AY+  E ++ G +   +D +SFGVV+LE + G  AV  H    
Sbjct: 338 --KFAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REP 393

Query: 432 KYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGL 491
           + L D+ EE  +E        + T++                   ++D +          
Sbjct: 394 QLLLDIKEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVE 427

Query: 492 GLGQLACCCLHRRAKRRPPMTQVYERLEKLQA 523
            +  +A  CLH +  +RP + +V + L+++ A
Sbjct: 428 AMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 459


>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score =  171 bits (432), Expect = 3e-42
 Identities = 110/326 (33%), Positives = 165/326 (50%), Gaps = 44/326 (13%)

Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
           E+   T+NF E        K+GEGGFG VY+  + NT  AVK+L    D+    +KQ F 
Sbjct: 48  ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107

Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
            E++ +++ +H N+V+  G+ +     CLVY ++PNGSL DRL C     PPLSW  R  
Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166

Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
           I  G A  I FLH++    IH DIKS+N+LLDE  T K+ DFGLAR S        + + 
Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE-------KFAQ 217

Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 437
              T  + GT AY+  E ++ G +   +D +SFGVV+LE + G  AV  H    + L D+
Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REPQLLLDI 275

Query: 438 VEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLA 497
            EE  +E        + T++                   ++D +           +  +A
Sbjct: 276 KEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVEAMYSVA 309

Query: 498 CCCLHRRAKRRPPMTQVYERLEKLQA 523
             CLH +  +RP + +V + L+++ A
Sbjct: 310 SQCLHEKKNKRPDIKKVQQLLQEMTA 335


>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score =  171 bits (432), Expect = 3e-42
 Identities = 110/326 (33%), Positives = 165/326 (50%), Gaps = 44/326 (13%)

Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
           E+   T+NF E        K+GEGGFG VY+  + NT  AVK+L    D+    +KQ F 
Sbjct: 48  ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107

Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
            E++ +++ +H N+V+  G+ +     CLVY ++PNGSL DRL C     PPLSW  R  
Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166

Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
           I  G A  I FLH++    IH DIKS+N+LLDE  T K+ DFGLAR S        + + 
Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE-------KFAQ 217

Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 437
              T  + GT AY+  E ++ G +   +D +SFGVV+LE + G  AV  H    + L D+
Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REPQLLLDI 275

Query: 438 VEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLA 497
            EE  +E        + T++                   ++D +           +  +A
Sbjct: 276 KEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVEAMYSVA 309

Query: 498 CCCLHRRAKRRPPMTQVYERLEKLQA 523
             CLH +  +RP + +V + L+++ A
Sbjct: 310 SQCLHEKKNKRPDIKKVQQLLQEMTA 335


>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
           [Homo sapiens]
          Length = 336

 Score =  171 bits (432), Expect = 3e-42
 Identities = 110/326 (33%), Positives = 165/326 (50%), Gaps = 44/326 (13%)

Query: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
           E+   T+NF E        K+GEGGFG VY+  + NT  AVK+L    D+    +KQ F 
Sbjct: 48  ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107

Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
            E++ +++ +H N+V+  G+ +     CLVY ++PNGSL DRL C     PPLSW  R  
Sbjct: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166

Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
           I  G A  I FLH++    IH DIKS+N+LLDE  T K+ DFGLAR S        + + 
Sbjct: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE-------KFAQ 217

Query: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 437
              T  + GT AY+  E ++ G +   +D +SFGVV+LE + G  AV  H    + L D+
Sbjct: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REPQLLLDI 275

Query: 438 VEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLA 497
            EE  +E        + T++                   ++D +           +  +A
Sbjct: 276 KEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVEAMYSVA 309

Query: 498 CCCLHRRAKRRPPMTQVYERLEKLQA 523
             CLH +  +RP + +V + L+++ A
Sbjct: 310 SQCLHEKKNKRPDIKKVQQLLQEMTA 335


>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
           sapiens]
          Length = 540

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 9/186 (4%)

Query: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296
           AVK L  +  L   + ++  L E E L + R   I+   G C +  F  +V  ++PNGSL
Sbjct: 45  AVKHLHIHTPL-LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSL 103

Query: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356
            + LH +T+  P ++WP R  IL   A  + +LH  +P L+H D+K+ N+LLD     K+
Sbjct: 104 NELLHRKTEY-PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162

Query: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG---RLAVDTDTFSFGVV 413
            DFGL+++ R    S S+SS   ++    GT+ Y+P E  + G   R ++  D +S+ V+
Sbjct: 163 ADFGLSKW-RMMSLSQSRSS---KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218

Query: 414 VLETLA 419
             E L+
Sbjct: 219 TWEVLS 224


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 73/228 (32%), Positives = 113/228 (49%), Gaps = 32/228 (14%)

Query: 215 ELK--IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV 272
           ELK  IG GGFG VYRA  +    AVK  +++ + +  A  +S   E    +  RHPNI+
Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNII 184

Query: 273 DFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLS-WPQR---------LDILLGT 322
           +  G C Q    CLV  F   G+L   L     A  P +  P+R         ++  +  
Sbjct: 185 ELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQI 244

Query: 323 ARAIQFLHQDS-PSLIHGDIKSSNVLLDERL--------TPKLGDFGLARFSRFAGSSPS 373
           AR + +LH+++   ++H D+KSSN+LL E++        T K+ DFGLAR          
Sbjct: 245 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR---------- 294

Query: 374 QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
           +     +  T  GT A++  E IK+   +  +D +S+GV++ E L G+
Sbjct: 295 EWHRTTKMSTA-GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGE 341


>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
           sapiens]
          Length = 648

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 86/288 (29%), Positives = 135/288 (46%), Gaps = 41/288 (14%)

Query: 150 SQTHSGPELGLVPSPASL----WPPPPSPAPSSTKPGPESSVSLL-----QGARPFPFCW 200
           S + S     L  SP +L    W  P +P P+  +  P S          +G R   + W
Sbjct: 283 SHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYW 342

Query: 201 PL--CEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK-QSFL 257
            +   E+   T       +IG G FG VY+      V AVK LK    ++ T  + Q+F 
Sbjct: 343 EIEASEVMLST-------RIGSGSFGTVYKGKWHGDV-AVKILKV---VDPTPEQFQAFR 391

Query: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
            EV  L + RH NI+ F GY  ++    +V  +    SL   LH Q          Q +D
Sbjct: 392 NEVAVLRKTRHVNILLFMGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMF---QLID 447

Query: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSS 376
           I   TA+ + +LH  + ++IH D+KS+N+ L E LT K+GDFGLA   SR++GS      
Sbjct: 448 IARQTAQGMDYLH--AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ----- 500

Query: 377 MVARTQTVRGTLAYLPEEYIK---TGRLAVDTDTFSFGVVVLETLAGQ 421
              + +   G++ ++  E I+       +  +D +S+G+V+ E + G+
Sbjct: 501 ---QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 545


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 105/416 (25%), Positives = 157/416 (37%), Gaps = 84/416 (20%)

Query: 201 PLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEV 260
           P CE++       EE+ IG GGFG VYR   R  + AVK  +++ D + +   +S   E 
Sbjct: 107 PPCEVASFQELRLEEV-IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEA 165

Query: 261 EQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLD 317
              +   HPNI+     C +    CLV  +   G L   L    +  PP   ++W  ++ 
Sbjct: 166 RLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL--AGRRVPPHVLVNWAVQI- 222

Query: 318 ILLGTARAIQFLHQDS-PSLIHGDIKSSNVLL--------DERLTPKLGDFGLARFSRFA 368
                AR + +LH ++   +IH D+KS+N+LL         E  T K+ DFGLAR     
Sbjct: 223 -----ARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----E 273

Query: 369 GSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHG 428
               +Q S         GT A++  E IK    +  +D +SFGV++ E L G        
Sbjct: 274 WHKTTQMS-------AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTG-------- 318

Query: 429 ARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPE 488
                       E    G+               D  A    + + K  L P P  CP  
Sbjct: 319 ------------EVPYRGI---------------DCLAVAYGVAVNKLTL-PIPSTCPEP 350

Query: 489 LGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYV 548
                 QL   C  +   RRP    + ++LE L+A V            +   P+++ + 
Sbjct: 351 ----FAQLMADCWAQDPHRRPDFASILQQLEALEAQV------------LREMPRDSFHS 394

Query: 549 SSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHL 604
              G        +  L A         E+L R   +     E L      L  W L
Sbjct: 395 MQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWEL 450



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 28/95 (29%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 104 PPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFP-GSQTHSGPELGLVP 162
           PP P P+P  T P PS +   +     SP   P+ A   L    P G ++   P     P
Sbjct: 678 PPTPTPAPCPTEPPPSPLICFSLKTPDSP---PTPAPLLLDLGIPVGQRSAKSPRREEEP 734

Query: 163 SPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFP 197
              ++ PPP +   +   PG   S  L   +RP P
Sbjct: 735 RGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRP 769


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 21/254 (8%)

Query: 169 PPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYR 228
           P P     S TK   ++ + LL+   P  F   L EI      F E   IG G FG VY+
Sbjct: 429 PSPLGKIKSMTKE--KADILLLRAGLPSHFHLQLSEIE-----FHEI--IGSGSFGKVYK 479

Query: 229 AVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQN-GFYCLV 287
              RN + A+KR + N     + V   F  EV  L +  HP ++ F G C  +   + +V
Sbjct: 480 GRCRNKIVAIKRYRANTYCSKSDVDM-FCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 538

Query: 288 YGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL 347
             ++  GSL   LH Q +    L    +L I +  A+ +++LH  +  +IH D+ S N+L
Sbjct: 539 TQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 595

Query: 348 LDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDT 407
           L E     + DFG +RF +    S  + +M  +   +R      PE + +  R  +  D 
Sbjct: 596 LYEDGHAVVADFGESRFLQ----SLDEDNMTKQPGNLRW---MAPEVFTQCTRYTIKADV 648

Query: 408 FSFGVVVLETLAGQ 421
           FS+ + + E L G+
Sbjct: 649 FSYALCLWEILTGE 662


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 21/254 (8%)

Query: 169 PPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYR 228
           P P     S TK   ++ + LL+   P  F   L EI      F E   IG G FG VY+
Sbjct: 530 PSPLGKIKSMTKE--KADILLLRAGLPSHFHLQLSEIE-----FHEI--IGSGSFGKVYK 580

Query: 229 AVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQN-GFYCLV 287
              RN + A+KR + N     + V   F  EV  L +  HP ++ F G C  +   + +V
Sbjct: 581 GRCRNKIVAIKRYRANTYCSKSDVDM-FCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 639

Query: 288 YGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL 347
             ++  GSL   LH Q +    L    +L I +  A+ +++LH  +  +IH D+ S N+L
Sbjct: 640 TQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 696

Query: 348 LDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDT 407
           L E     + DFG +RF +    S  + +M  +   +R      PE + +  R  +  D 
Sbjct: 697 LYEDGHAVVADFGESRFLQ----SLDEDNMTKQPGNLRW---MAPEVFTQCTRYTIKADV 749

Query: 408 FSFGVVVLETLAGQ 421
           FS+ + + E L G+
Sbjct: 750 FSYALCLWEILTGE 763


>gi|38327632 discoidin domain receptor family, member 1 isoform b
           [Homo sapiens]
          Length = 876

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 116/468 (24%), Positives = 175/468 (37%), Gaps = 113/468 (24%)

Query: 97  DIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGP 156
           D I   + P P   P    PRP   P             P SA     P  P    +SG 
Sbjct: 468 DTILINNRPGPREPPPYQEPRPRGNP-------------PHSA-----PCVPNGSAYSGD 509

Query: 157 ELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQG----------ARPFPFCW---PLC 203
            +      A L PPPP    +S     E+ +  LQG          A P        P  
Sbjct: 510 YMEPEKPGAPLLPPPPQ---NSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRV 566

Query: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMRNT------------------VYAVKRLKENA 245
           +  R    F E  K+GEG FG V+   + +                   + AVK L+ +A
Sbjct: 567 DFPRSRLRFKE--KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA 624

Query: 246 DLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC--- 302
                  +  FL EV+ +SR + PNI+   G C Q+   C++  ++ NG L   L     
Sbjct: 625 TKN---ARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 681

Query: 303 ------------QTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDE 350
                       Q    P +S+P  L +    A  +++L   + + +H D+ + N L+ E
Sbjct: 682 EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL--ATLNFVHRDLATRNCLVGE 739

Query: 351 RLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSF 410
             T K+ DFG++R + +AG                  + ++  E I  G+    +D ++F
Sbjct: 740 NFTIKIADFGMSR-NLYAGDYYRVQGRAVL------PIRWMAWECILMGKFTTASDVWAF 792

Query: 411 GVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIA 470
           GV + E L   RA +  G  T       E+  E AG   R                    
Sbjct: 793 GVTLWEVLMLCRA-QPFGQLTD------EQVIENAGEFFRDQ-----------------G 828

Query: 471 MQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERL 518
            Q+Y      RP  CP     GL +L   C  R +++RPP +Q++  L
Sbjct: 829 RQVYLS----RPPACPQ----GLYELMLRCWSRESEQRPPFSQLHRFL 868


>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
           sapiens]
          Length = 606

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 68/222 (30%), Positives = 112/222 (50%), Gaps = 21/222 (9%)

Query: 217 KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG 276
           +IG G FG V+R      V AVK LK +      A  Q+F  E++ L + RH NI+ F G
Sbjct: 315 RIGTGSFGTVFRGRWHGDV-AVKVLKVSQPTAEQA--QAFKNEMQVLRKTRHVNILLFMG 371

Query: 277 YCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSL 336
           +  + GF  ++  +    SL   LH    A       Q +D+   TA+ + +LH  + ++
Sbjct: 372 FMTRPGF-AIITQWCEGSSLYHHLHV---ADTRFDMVQLIDVARQTAQGMDYLH--AKNI 425

Query: 337 IHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395
           IH D+KS+N+ L E LT K+GDFGLA   +R++G+ P +           G++ ++  E 
Sbjct: 426 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQP--------SGSVLWMAAEV 477

Query: 396 IK---TGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYL 434
           I+       +  +D +++GVV+ E + G       G R + +
Sbjct: 478 IRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQII 519


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 72/253 (28%), Positives = 110/253 (43%), Gaps = 42/253 (16%)

Query: 181 PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR 240
           PG  ++ + LQ  +  PF           H    E  IG GGFG VYRA+ R    AVK 
Sbjct: 78  PGAPAAPAGLQLPQEIPF-----------HELQLEEIIGVGGFGKVYRALWRGEEVAVKA 126

Query: 241 LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 300
            + + + +     +    E       +HPNI+   G C      CLV  +   G+L   L
Sbjct: 127 ARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL 186

Query: 301 HCQTQACPP---LSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERL---- 352
               +  PP   ++W  ++      AR + +LH D+P  +IH D+KS N+L+ E +    
Sbjct: 187 --AGRRVPPHVLVNWAVQV------ARGMNYLHNDAPVPIIHRDLKSINILILEAIENHN 238

Query: 353 ----TPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTF 408
                 K+ DFGLAR                   +  GT A++  E I+    +  +D +
Sbjct: 239 LADTVLKITDFGLAR-----------EWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVW 287

Query: 409 SFGVVVLETLAGQ 421
           SFGV++ E L G+
Sbjct: 288 SFGVLLWELLTGE 300



 Score = 30.0 bits (66), Expect = 7.8
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 9/95 (9%)

Query: 92  LLRARDIITAWHPPAPLPSPGTTAPRPSSIPAP---AEAEAWSPRKLPSSASTFLSPAFP 148
           LLR+     A   P+P PSP    P PS    P    E E++      S   T ++ A  
Sbjct: 761 LLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACA 820

Query: 149 GSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGP 183
            S+ H        PS  +L    P P P+   PGP
Sbjct: 821 VSRGHR-----RTPSDGALGQRGP-PEPAGHGPGP 849


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 59/209 (28%), Positives = 99/209 (47%), Gaps = 27/209 (12%)

Query: 213 SEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV 272
           SE   +G G  G V+    R    A+K+++E  +           T+++ L + +HPNI+
Sbjct: 169 SELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----------TDIKHLRKLKHPNII 217

Query: 273 DFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD 332
            F G C Q   YC++  +  +G L + L    +  P L     +D   G A  + +LH  
Sbjct: 218 AFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL----LVDWSTGIASGMNYLHLH 273

Query: 333 SPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLP 392
              +IH D+KS NVL+      K+ DFG ++          + S  +   +  GT+A++ 
Sbjct: 274 --KIIHRDLKSPNVLVTHTDAVKISDFGTSK----------ELSDKSTKMSFAGTVAWMA 321

Query: 393 EEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
            E I+   ++   D +SFGVV+ E L G+
Sbjct: 322 PEVIRNEPVSEKVDIWSFGVVLWELLTGE 350


>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
          Length = 626

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 82/285 (28%), Positives = 123/285 (43%), Gaps = 38/285 (13%)

Query: 155 GPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE 214
           GP  G VP      PP P         G  SS   L+ A        +  ++R   +F  
Sbjct: 12  GPGPGEVPGEG---PPGPGGTGGGPGRGRPSSYRALRSA--------VSSLAR-VDDFHC 59

Query: 215 ELKIGEGGFGCVYRAVMRNT----VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPN 270
             KIG G F  VY+   R +    V  + +L  N        + + L EV+ ++R RHPN
Sbjct: 60  AEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN--------RGNTLREVQLMNRLRHPN 111

Query: 271 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 330
           I+ F G C   G    +  ++  G+LE  L     +  PLSWP RL + L  AR +++LH
Sbjct: 112 ILRFMGVCVHQGQLHALTEYMNGGTLEQLL----SSPEPLSWPVRLHLALDIARGLRYLH 167

Query: 331 QDSPSLIHGDIKSSNVLL---DERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGT 387
             S  + H D+ S N L+   D   T  +GDFGLA           +  +      V G+
Sbjct: 168 --SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPL-----AVVGS 220

Query: 388 LAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTK 432
             ++  E ++        D F+FG+V+ E +A   A   +  RT+
Sbjct: 221 PYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTE 265


>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
           sapiens]
          Length = 518

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 71/206 (34%), Positives = 99/206 (48%), Gaps = 16/206 (7%)

Query: 218 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 277
           +G+GGFG V+RA  R   Y V     N+      VK     + E + R     +++   +
Sbjct: 27  VGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLE--GVIEKVNW 84

Query: 278 CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLI 337
             Q+    LV  F+ NGSL   L  Q     P  WP    +L      + +LH  +P L+
Sbjct: 85  -DQDPKPALVTKFMENGSLSGLLQSQC----PRPWPLLCRLLKEVVLGMFYLHDQNPVLL 139

Query: 338 HGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PEEYI 396
           H D+K SNVLLD  L  KL DFGL   S F G S S +     +    GTL YL PE ++
Sbjct: 140 HRDLKPSNVLLDPELHVKLADFGL---STFQGGSQSGTG----SGEPGGTLGYLAPELFV 192

Query: 397 KTGRLA-VDTDTFSFGVVVLETLAGQ 421
              R A   +D +SFG+++   LAG+
Sbjct: 193 NVNRKASTASDVYSFGILMWAVLAGR 218


>gi|33188459 B-Raf [Homo sapiens]
          Length = 766

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 68/209 (32%), Positives = 105/209 (50%), Gaps = 21/209 (10%)

Query: 217 KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG 276
           +IG G FG VY+      V AVK L   A        Q+F  EV  L + RH NI+ F G
Sbjct: 462 RIGSGSFGTVYKGKWHGDV-AVKMLNVTAPTPQQL--QAFKNEVGVLRKTRHVNILLFMG 518

Query: 277 YCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSL 336
           Y  +     +V  +    SL   LH        +   + +DI   TA+ + +LH  + S+
Sbjct: 519 YSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMI---KLIDIARQTAQGMDYLH--AKSI 572

Query: 337 IHGDIKSSNVLLDERLTPKLGDFGLARF-SRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395
           IH D+KS+N+ L E LT K+GDFGLA   SR++GS         + + + G++ ++  E 
Sbjct: 573 IHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSH--------QFEQLSGSILWMAPEV 624

Query: 396 IK---TGRLAVDTDTFSFGVVVLETLAGQ 421
           I+       +  +D ++FG+V+ E + GQ
Sbjct: 625 IRMQDKNPYSFQSDVYAFGIVLYELMTGQ 653


>gi|83977450 discoidin domain receptor family, member 1 isoform a
           [Homo sapiens]
          Length = 913

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 116/479 (24%), Positives = 179/479 (37%), Gaps = 120/479 (25%)

Query: 111 PGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLS--------------PAFPG------- 149
           PG   P P   P P      S   +P+ ++  LS              P  PG       
Sbjct: 476 PGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWA 535

Query: 150 ----SQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQG----------ARP 195
               +Q +SG  +      A L PPPP    +S     E+ +  LQG          A P
Sbjct: 536 KPTNTQAYSGDYMEPEKPGAPLLPPPPQ---NSVPHYAEADIVTLQGVTGGNTYAVPALP 592

Query: 196 FPFCW---PLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT------------------ 234
                   P  +  R    F E  K+GEG FG V+   + +                   
Sbjct: 593 PGAVGDGPPRVDFPRSRLRFKE--KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL 650

Query: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294
           + AVK L+ +A       +  FL EV+ +SR + PNI+   G C Q+   C++  ++ NG
Sbjct: 651 LVAVKILRPDATKN---ARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENG 707

Query: 295 SLEDRLHC---------------QTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHG 339
            L   L                 Q    P +S+P  L +    A  +++L   + + +H 
Sbjct: 708 DLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL--ATLNFVHR 765

Query: 340 DIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG 399
           D+ + N L+ E  T K+ DFG++R + +AG                  + ++  E I  G
Sbjct: 766 DLATRNCLVGENFTIKIADFGMSR-NLYAGDYYRVQGRAVL------PIRWMAWECILMG 818

Query: 400 RLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAG 459
           +    +D ++FGV + E L   RA +  G  T       E+  E AG   R         
Sbjct: 819 KFTTASDVWAFGVTLWEVLMLCRA-QPFGQLTD------EQVIENAGEFFRDQ------- 864

Query: 460 LAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERL 518
                       Q+Y      RP  CP     GL +L   C  R +++RPP +Q++  L
Sbjct: 865 ----------GRQVYLS----RPPACPQ----GLYELMLRCWSRESEQRPPFSQLHRFL 905


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 52/280 (18%)

Query: 158 LGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSE--- 214
           +G+ PS    +  P S   S  +PG E            P C+P  ++     +F+E   
Sbjct: 103 VGIFPSN---YVTPRSAFSSRCQPGGED-----------PSCYPPIQLLE--IDFAELTL 146

Query: 215 ELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 274
           E  IG GGFG VYRA       AVK  + + D + +   ++   E +  +  +HPNI+  
Sbjct: 147 EEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIAL 206

Query: 275 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLDILLGTARAIQFLHQ 331
            G C +    CLV  F   G L   L    +  PP   ++W  ++      AR + +LH 
Sbjct: 207 RGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQI------ARGMNYLHD 258

Query: 332 DS-PSLIHGDIKSSNVLLDERLTP--------KLGDFGLAR-FSRFAGSSPSQSSMVART 381
           ++   +IH D+KSSN+L+ +++          K+ DFGLAR + R    S +        
Sbjct: 259 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA-------- 310

Query: 382 QTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
               GT A++  E I+    +  +D +S+GV++ E L G+
Sbjct: 311 ----GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGE 346


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 78/312 (25%), Positives = 124/312 (39%), Gaps = 67/312 (21%)

Query: 218 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 277
           +G G  G V+         AVK++++  +           T+++ L + +HPNI+ F G 
Sbjct: 131 VGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----------TDIKHLRKLKHPNIITFKGV 179

Query: 278 CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLI 337
           C Q   YC++  F   G L + L       P L     +D  +G A  + +LH     +I
Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL----LVDWSMGIAGGMNYLHLH--KII 233

Query: 338 HGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIK 397
           H D+KS N+L+      K+ DFG ++          + S  +   +  GT+A++  E I+
Sbjct: 234 HRDLKSPNMLITYDDVVKISDFGTSK----------ELSDKSTKMSFAGTVAWMAPEVIR 283

Query: 398 TGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQ 457
              ++   D +SFGVV+ E L G+   K            V+  A   GV   S      
Sbjct: 284 NEPVSEKVDIWSFGVVLWELLTGEIPYKD-----------VDSSAIIWGVGSNSL----- 327

Query: 458 AGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYER 517
                              HL P P  CP    + L Q    C + + + RP   Q+   
Sbjct: 328 -------------------HL-PVPSSCPDGFKILLRQ----CWNSKPRNRPSFRQILLH 363

Query: 518 LEKLQAVVAGVP 529
           L+   A V   P
Sbjct: 364 LDIASADVLSTP 375


>gi|83977452 discoidin domain receptor family, member 1 isoform c
           [Homo sapiens]
          Length = 919

 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 116/482 (24%), Positives = 180/482 (37%), Gaps = 120/482 (24%)

Query: 111 PGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLS--------------PAFPG------- 149
           PG   P P   P P      S   +P+ ++  LS              P  PG       
Sbjct: 476 PGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWA 535

Query: 150 ----SQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQG----------ARP 195
               +Q +SG  +      A L PPPP    +S     E+ +  LQG          A P
Sbjct: 536 KPTNTQAYSGDYMEPEKPGAPLLPPPPQ---NSVPHYAEADIVTLQGVTGGNTYAVPALP 592

Query: 196 FPFCW---PLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT------------------ 234
                   P  +  R    F E  K+GEG FG V+   + +                   
Sbjct: 593 PGAVGDGPPRVDFPRSRLRFKE--KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL 650

Query: 235 VYAVKRLKENADLEWTAV---KQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFL 291
           + AVK L+ +A    +     +  FL EV+ +SR + PNI+   G C Q+   C++  ++
Sbjct: 651 LVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM 710

Query: 292 PNGSLEDRLHC---------------QTQACPPLSWPQRLDILLGTARAIQFLHQDSPSL 336
            NG L   L                 Q    P +S+P  L +    A  +++L   + + 
Sbjct: 711 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL--ATLNF 768

Query: 337 IHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYI 396
           +H D+ + N L+ E  T K+ DFG++R + +AG                  + ++  E I
Sbjct: 769 VHRDLATRNCLVGENFTIKIADFGMSR-NLYAGDYYRVQGRAVL------PIRWMAWECI 821

Query: 397 KTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTL 456
             G+    +D ++FGV + E L   RA +  G  T       E+  E AG   R      
Sbjct: 822 LMGKFTTASDVWAFGVTLWEVLMLCRA-QPFGQLTD------EQVIENAGEFFRDQ---- 870

Query: 457 QAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYE 516
                          Q+Y      RP  CP     GL +L   C  R +++RPP +Q++ 
Sbjct: 871 -------------GRQVYLS----RPPACPQ----GLYELMLRCWSRESEQRPPFSQLHR 909

Query: 517 RL 518
            L
Sbjct: 910 FL 911


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 69/210 (32%), Positives = 102/210 (48%), Gaps = 19/210 (9%)

Query: 217 KIGEGGFGCVY--RAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 274
           K+G GGFG VY  R V   T  A+K    +  ++    +   L E +++   +   I+  
Sbjct: 27  KVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVD-DRERMELLEEAKKMEMAKFRYILPV 84

Query: 275 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 334
            G C +     LV  ++  GSLE  L     A  PL W  R  I+  TA  + FLH  +P
Sbjct: 85  YGICREP--VGLVMEYMETGSLEKLL-----ASEPLPWDLRFRIIHETAVGMNFLHCMAP 137

Query: 335 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 394
            L+H D+K +N+LLD     K+ DFGLA+ +   G S S    +     + GT+AYLP E
Sbjct: 138 PLLHLDLKPANILLDAHYHVKISDFGLAKCN---GLSHSHDLSM---DGLFGTIAYLPPE 191

Query: 395 YIKTGRLAVDT--DTFSFGVVVLETLAGQR 422
            I+      DT  D +SF +V+   L  ++
Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKK 221


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 61/209 (29%), Positives = 95/209 (45%), Gaps = 16/209 (7%)

Query: 218 IGEGGFGCVYRAVMRN--TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 275
           +  GGF  V++A  R   T YA+K          ++     + E  ++ + +  +IV   
Sbjct: 28  VASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIY 87

Query: 276 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 335
           G C Q     +V  F+ NGSLE  L   +     L W  R  I+  T+ A+ FLH   P 
Sbjct: 88  GVCKQP--LGIVMEFMANGSLEKVLSTHS-----LCWKLRFRIIHETSLAMNFLHSIKPP 140

Query: 336 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 395
           L+H D+K  N+LLD  +  K+ DFGL+++        S          +RG L+Y+P E 
Sbjct: 141 LLHLDLKPGNILLDSNMHVKISDFGLSKW-----MEQSTRMQYIERSALRGMLSYIPPEM 195

Query: 396 IKTGRLAVDT--DTFSFGVVVLETLAGQR 422
                 A     D +SF +V+ E L  ++
Sbjct: 196 FLESNKAPGPKYDVYSFAIVIWELLTQKK 224


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,124,690
Number of Sequences: 37866
Number of extensions: 2007453
Number of successful extensions: 22842
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 540
Number of HSP's successfully gapped in prelim test: 1146
Number of HSP's that attempted gapping in prelim test: 14663
Number of HSP's gapped (non-prelim): 6763
length of query: 712
length of database: 18,247,518
effective HSP length: 109
effective length of query: 603
effective length of database: 14,120,124
effective search space: 8514434772
effective search space used: 8514434772
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.