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Search of human proteins with 68799814
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68799814 adaptor-related protein complex 2, mu 1 subunit
isoform b [Homo sapiens]
(433 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68799814 adaptor-related protein complex 2, mu 1 subunit isof... 862 0.0
gi|14917109 adaptor-related protein complex 2, mu 1 subunit isof... 857 0.0
gi|9506797 adaptor-related protein complex 1, mu 2 subunit [Homo... 335 6e-92
gi|14210504 adaptor-related protein complex 1, mu 1 subunit isof... 331 7e-91
gi|194473724 adaptor-related protein complex 1, mu 1 subunit iso... 322 3e-88
gi|14917111 adaptor-related protein complex 4, mu 1 subunit [Hom... 183 2e-46
gi|6912240 adaptor-related protein complex 3, mu 1 subunit [Homo... 161 1e-39
gi|46370095 adaptor-related protein complex 3, mu 1 subunit [Hom... 161 1e-39
gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Ho... 156 3e-38
gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo... 156 3e-38
gi|21361863 stonin 2 [Homo sapiens] 76 7e-14
gi|26787993 stonin 1 [Homo sapiens] 61 2e-09
gi|29553944 STON1-GTF2A1L protein [Homo sapiens] 61 2e-09
gi|88703051 adaptor-related protein complex 1, sigma 3 subunit [... 41 0.002
gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [H... 38 0.020
gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [H... 37 0.035
gi|70906430 adaptor-related protein complex 2, sigma 1 subunit i... 37 0.046
gi|189409104 adaptor-related protein complex 4, sigma 1 subunit ... 35 0.10
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 35 0.17
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 35 0.17
gi|131889097 cancer susceptibility candidate 1 isoform b [Homo s... 32 1.1
gi|131889447 cancer susceptibility candidate 1 isoform c [Homo s... 32 1.1
gi|131888105 cancer susceptibility candidate 1 isoform a [Homo s... 32 1.1
gi|38348406 leucine rich repeat containing 33 [Homo sapiens] 31 2.5
gi|11863154 archain isoform 1 [Homo sapiens] 30 3.3
gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide... 30 4.3
gi|29150261 interferon, gamma-inducible protein 30 preproprotein... 30 5.6
gi|31742501 sorting nexin family member 27 [Homo sapiens] 29 7.3
>gi|68799814 adaptor-related protein complex 2, mu 1 subunit isoform
b [Homo sapiens]
Length = 433
Score = 862 bits (2226), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR 60
MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR
Sbjct: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR 60
Query: 61 SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY 120
SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY
Sbjct: 61 SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY 120
Query: 121 PQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVN 180
PQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVN
Sbjct: 121 PQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVN 180
Query: 181 LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIA 240
LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIA
Sbjct: 181 LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIA 240
Query: 241 IDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLE 300
IDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLE
Sbjct: 241 IDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLE 300
Query: 301 VKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMK 360
VKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMK
Sbjct: 301 VKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMK 360
Query: 361 ESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWV 420
ESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWV
Sbjct: 361 ESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWV 420
Query: 421 RYIGRSGIYETRC 433
RYIGRSGIYETRC
Sbjct: 421 RYIGRSGIYETRC 433
>gi|14917109 adaptor-related protein complex 2, mu 1 subunit isoform
a [Homo sapiens]
Length = 435
Score = 857 bits (2213), Expect = 0.0
Identities = 433/435 (99%), Positives = 433/435 (99%), Gaps = 2/435 (0%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR 60
MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR
Sbjct: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKR 60
Query: 61 SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY 120
SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY
Sbjct: 61 SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGY 120
Query: 121 PQNSETGALKTFITQQGIKSQ--TKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES 178
PQNSETGALKTFITQQGIKSQ TKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES
Sbjct: 121 PQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES 180
Query: 179 VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS 238
VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS
Sbjct: 181 VNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQS 240
Query: 239 IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTK 298
IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTK
Sbjct: 241 IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTK 300
Query: 299 LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAG 358
LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAG
Sbjct: 301 LEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAG 360
Query: 359 MKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIK 418
MKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIK
Sbjct: 361 MKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIK 420
Query: 419 WVRYIGRSGIYETRC 433
WVRYIGRSGIYETRC
Sbjct: 421 WVRYIGRSGIYETRC 435
>gi|9506797 adaptor-related protein complex 1, mu 2 subunit [Homo
sapiens]
Length = 423
Score = 335 bits (858), Expect = 6e-92
Identities = 166/430 (38%), Positives = 268/430 (62%), Gaps = 16/430 (3%)
Query: 5 LFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHVKRSNI 63
+FI + KG+ LISR Y+ D+ + ++ F ++ ++ +P+ + + F +K SN+
Sbjct: 6 VFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWIKHSNL 65
Query: 64 WLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQN 123
+L A T +N NA++V+ FLYK +V YF ++ EE+I++NFV++YELLDE++DFG+PQ
Sbjct: 66 YLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQT 125
Query: 124 SETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLM 183
+++ L+ +ITQQ K +T + S++ VT + WR EGIKY++NE+F+DV+ESVNLL+
Sbjct: 126 TDSKILQEYITQQSNKLETGK--SRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLV 183
Query: 184 SPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDD 243
+ G VL + + G + +K +LSGMPE + G+ND+++ E G+ S +S+ ++D
Sbjct: 184 NANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGR--------SKNKSVELED 235
Query: 244 CTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKV 303
FHQCVRLS+FD++R+ISFIPPDG+FELM YR + + + ++ + +++E+ V
Sbjct: 236 VKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMV 295
Query: 304 VIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQ 363
K FK +A +E+ +P P + + G AKY N ++W IK G KE
Sbjct: 296 KAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYL 355
Query: 364 ISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRY 422
+ A L ++ RPPI + FE+P F SG++VRY+K+ E S + + WVRY
Sbjct: 356 MRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEK----SGYQALPWVRY 411
Query: 423 IGRSGIYETR 432
I +SG Y+ R
Sbjct: 412 ITQSGDYQLR 421
>gi|14210504 adaptor-related protein complex 1, mu 1 subunit isoform
2 [Homo sapiens]
Length = 423
Score = 331 bits (849), Expect = 7e-91
Identities = 171/430 (39%), Positives = 265/430 (61%), Gaps = 16/430 (3%)
Query: 5 LFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHVKRSNI 63
+++ + KG+VLI R YR D+ + V+ F ++ ++ + SP+ F +K +N+
Sbjct: 6 VYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNL 65
Query: 64 WLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQN 123
+L A +K+N ++VF FLYK+ V + YF ++ EE+I++NFV+IYELLDE++DFGYPQ
Sbjct: 66 YLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQT 125
Query: 124 SETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLM 183
+++ L+ +ITQ+G K +T + T VT + WR EGIKYR+NE+FLDV+ESVNLL+
Sbjct: 126 TDSKILQEYITQEGHKLETGAPRPPAT--VTNAVSWRSEGIKYRKNEVFLDVIESVNLLV 183
Query: 184 SPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDD 243
S G VL + + G + M+ +LSGMPE + G+NDK++ + G+G + +S+ ++D
Sbjct: 184 SANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS--------KSVELED 235
Query: 244 CTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKV 303
FHQCVRLS+F+++R+ISFIPPDGEFELM YR + + ++ + +++E +
Sbjct: 236 VKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMI 295
Query: 304 VIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQ 363
KS FK A +E+ IP P + + G K+ + IVW IK G KE
Sbjct: 296 KAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYL 355
Query: 364 ISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRY 422
+ A L + K +PPIS+ FE+P F SG++VRYLK+ E S + + WVRY
Sbjct: 356 MRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEK----SGYQALPWVRY 411
Query: 423 IGRSGIYETR 432
I ++G Y+ R
Sbjct: 412 ITQNGDYQLR 421
>gi|194473724 adaptor-related protein complex 1, mu 1 subunit
isoform 1 [Homo sapiens]
Length = 435
Score = 322 bits (826), Expect = 3e-88
Identities = 171/442 (38%), Positives = 265/442 (59%), Gaps = 28/442 (6%)
Query: 5 LFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHVKRSNI 63
+++ + KG+VLI R YR D+ + V+ F ++ ++ + SP+ F +K +N+
Sbjct: 6 VYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNL 65
Query: 64 WLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQN 123
+L A +K+N ++VF FLYK+ V + YF ++ EE+I++NFV+IYELLDE++DFGYPQ
Sbjct: 66 YLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQT 125
Query: 124 SETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLL- 182
+++ L+ +ITQ+G K +T + T VT + WR EGIKYR+NE+FLDV+ESVNLL
Sbjct: 126 TDSKILQEYITQEGHKLETGAPRPPAT--VTNAVSWRSEGIKYRKNEVFLDVIESVNLLG 183
Query: 183 -----------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADET 231
+S G VL + + G + M+ +LSGMPE + G+NDK++ + G+G +
Sbjct: 184 KYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS--- 240
Query: 232 SKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLV 291
+S+ ++D FHQCVRLS+F+++R+ISFIPPDGEFELM YR + + ++
Sbjct: 241 -----KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVI 295
Query: 292 REVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVW 351
+ +++E + KS FK A +E+ IP P + + G K+ + IVW
Sbjct: 296 EKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVW 355
Query: 352 KIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLN 410
IK G KE + A L + K +PPIS+ FE+P F SG++VRYLK+ E
Sbjct: 356 SIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEK--- 412
Query: 411 YSDHDVIKWVRYIGRSGIYETR 432
S + + WVRYI ++G Y+ R
Sbjct: 413 -SGYQALPWVRYITQNGDYQLR 433
>gi|14917111 adaptor-related protein complex 4, mu 1 subunit [Homo
sapiens]
Length = 453
Score = 183 bits (465), Expect = 2e-46
Identities = 130/464 (28%), Positives = 225/464 (48%), Gaps = 44/464 (9%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVT-NIARTSFFHVK 59
MI FI + KG+ LI + +R D G V + SPV + F H++
Sbjct: 1 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR 60
Query: 60 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG 119
S ++L T +NV+ + E L ++ ++ Y G + E I N L+YELLDE+LD+G
Sbjct: 61 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG 120
Query: 120 YPQNSETGALKTFITQQGIKSQ--------------TKEEQSQIT-SQVTGQIGWRREGI 164
Y Q + T L+ FI + + S+ + +QS++ S +
Sbjct: 121 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD 180
Query: 165 KYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG 224
+ ++NE+FLDV+E +++L++ G +L V G + +KS+L E + G+ ++ + K
Sbjct: 181 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGK-- 238
Query: 225 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDI--I 282
+ I +D+ +FH V L +F+S R + PP GE +MRY+ + D+
Sbjct: 239 -----SELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP 293
Query: 283 LPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK 341
LPFR+ P V+ + G +L+V + ++ + A + + +P P + + K
Sbjct: 294 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK 353
Query: 342 YKASENAIVWKIKRMAGMKESQISAEIEL-------LPTNDKKKWARP----PISMNFEV 390
+ +E A+ W + R+ G SQ+S ++ P++ A P P S++FE+
Sbjct: 354 AELAEGALRWDLPRVQG--GSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFEL 411
Query: 391 P-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIGRSGIYETR 432
P SGL+VR+L++ F P N + H KWVR++ S Y R
Sbjct: 412 PRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLSHSDAYVIR 452
>gi|6912240 adaptor-related protein complex 3, mu 1 subunit [Homo
sapiens]
Length = 418
Score = 161 bits (407), Expect = 1e-39
Identities = 113/452 (25%), Positives = 205/452 (45%), Gaps = 55/452 (12%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRS-----PVTNIARTSF 55
MI LF+ N G++ + + ++ + ++ D F A+++ PV +
Sbjct: 1 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYF----FEAQEKAADVENVPPVISTPHHYL 56
Query: 56 FHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEI 115
+ R ++ +V + V V EFL+++ D YFG+ SE IK+N V++YELL+E+
Sbjct: 57 ISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEM 116
Query: 116 LDFGYPQNSETGALKTFI--------TQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYR 167
LD G+P +E+ LK I I + + T Q++ I WRR G+KY
Sbjct: 117 LDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLS-NIPWRRAGVKYT 175
Query: 168 RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFG-MNDKIVIEKQGKG 226
NE + DV+E ++ ++ G + A + G + LSGMP+ MN ++
Sbjct: 176 NNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRL-------- 227
Query: 227 TADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFR 286
+DD +FH C+R +++SER +SFIPPDG F L+ YR + ++
Sbjct: 228 --------------LDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIP 273
Query: 287 V-----IPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK 341
V I + ++ + K N ++ + I V + P + + +G
Sbjct: 274 VYVKHSISFKENSSCGRFDITIGPKQNMGKTI--EGITVTVHMPKVVLNMNLTPTQGSYT 331
Query: 342 YKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEV-PFAPSGLKVR 400
+ + W + ++ K + + L + K P +++ F++ A SGLKV
Sbjct: 332 FDPVTKVLTWDVGKITPQKLPSLKGLVN-LQSGAPKPEENPSLNIQFKIQQLAISGLKVN 390
Query: 401 YLKVFEPKLNYSDHDVIKWVRYIGRSGIYETR 432
L ++ K + K V+Y+ ++G ++ R
Sbjct: 391 RLDMYGEK-----YKPFKGVKYVTKAGKFQVR 417
>gi|46370095 adaptor-related protein complex 3, mu 1 subunit [Homo
sapiens]
Length = 418
Score = 161 bits (407), Expect = 1e-39
Identities = 113/452 (25%), Positives = 205/452 (45%), Gaps = 55/452 (12%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRS-----PVTNIARTSF 55
MI LF+ N G++ + + ++ + ++ D F A+++ PV +
Sbjct: 1 MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYF----FEAQEKAADVENVPPVISTPHHYL 56
Query: 56 FHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEI 115
+ R ++ +V + V V EFL+++ D YFG+ SE IK+N V++YELL+E+
Sbjct: 57 ISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEM 116
Query: 116 LDFGYPQNSETGALKTFI--------TQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYR 167
LD G+P +E+ LK I I + + T Q++ I WRR G+KY
Sbjct: 117 LDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLS-NIPWRRAGVKYT 175
Query: 168 RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFG-MNDKIVIEKQGKG 226
NE + DV+E ++ ++ G + A + G + LSGMP+ MN ++
Sbjct: 176 NNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRL-------- 227
Query: 227 TADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFR 286
+DD +FH C+R +++SER +SFIPPDG F L+ YR + ++
Sbjct: 228 --------------LDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIP 273
Query: 287 V-----IPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK 341
V I + ++ + K N ++ + I V + P + + +G
Sbjct: 274 VYVKHSISFKENSSCGRFDITIGPKQNMGKTI--EGITVTVHMPKVVLNMNLTPTQGSYT 331
Query: 342 YKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEV-PFAPSGLKVR 400
+ + W + ++ K + + L + K P +++ F++ A SGLKV
Sbjct: 332 FDPVTKVLTWDVGKITPQKLPSLKGLVN-LQSGAPKPEENPSLNIQFKIQQLAISGLKVN 390
Query: 401 YLKVFEPKLNYSDHDVIKWVRYIGRSGIYETR 432
L ++ K + K V+Y+ ++G ++ R
Sbjct: 391 RLDMYGEK-----YKPFKGVKYVTKAGKFQVR 417
>gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Homo
sapiens]
Length = 418
Score = 156 bits (395), Expect = 3e-38
Identities = 117/447 (26%), Positives = 200/447 (44%), Gaps = 45/447 (10%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVR-SPVTNIARTSFFHVK 59
MI LF+ N G++ + + ++ + R+ D F A + PV V
Sbjct: 1 MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVY 60
Query: 60 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG 119
R I+ AV + V V EFL+++ D YFG SE IK+N V++YE+L+E+LD G
Sbjct: 61 RHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNG 120
Query: 120 YPQNSETGALKTFITQQGIKS---QTKEEQSQITSQV-TGQIG---WRREGIKYRRNELF 172
+P +E+ LK I I T + + Q+ TGQ+ WRR G+KY NE +
Sbjct: 121 FPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAY 180
Query: 173 LDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFG-MNDKIVIEKQGKGTADET 231
DV+E ++ ++ G ++A + G + L+GMP+ MN ++
Sbjct: 181 FDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRL------------- 227
Query: 232 SKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRV---- 287
+DD +FH CVR +++SER +SFIPPDG F L+ Y + ++ V
Sbjct: 228 ---------LDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKH 278
Query: 288 -IPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASE 346
I + E+ V K ++ + + V P + + +G +
Sbjct: 279 NISFRDSSSLGRFEITVGPKQTMGKTI--EGVTVTSQMPKGVLNMSLTPSQGTHTFDPVT 336
Query: 347 NAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEV-PFAPSGLKVRYLKVF 405
+ W + ++ K + + L K P I++ F++ A SGLKV L ++
Sbjct: 337 KMLSWDVGKINPQKLPSLKGTMS-LQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMY 395
Query: 406 EPKLNYSDHDVIKWVRYIGRSGIYETR 432
K + K ++Y+ ++G ++ R
Sbjct: 396 GEK-----YKPFKGIKYMTKAGKFQVR 417
>gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo
sapiens]
Length = 418
Score = 156 bits (395), Expect = 3e-38
Identities = 117/447 (26%), Positives = 200/447 (44%), Gaps = 45/447 (10%)
Query: 1 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVR-SPVTNIARTSFFHVK 59
MI LF+ N G++ + + ++ + R+ D F A + PV V
Sbjct: 1 MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVY 60
Query: 60 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG 119
R I+ AV + V V EFL+++ D YFG SE IK+N V++YE+L+E+LD G
Sbjct: 61 RHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNG 120
Query: 120 YPQNSETGALKTFITQQGIKS---QTKEEQSQITSQV-TGQIG---WRREGIKYRRNELF 172
+P +E+ LK I I T + + Q+ TGQ+ WRR G+KY NE +
Sbjct: 121 FPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAY 180
Query: 173 LDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFG-MNDKIVIEKQGKGTADET 231
DV+E ++ ++ G ++A + G + L+GMP+ MN ++
Sbjct: 181 FDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRL------------- 227
Query: 232 SKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRV---- 287
+DD +FH CVR +++SER +SFIPPDG F L+ Y + ++ V
Sbjct: 228 ---------LDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKH 278
Query: 288 -IPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASE 346
I + E+ V K ++ + + V P + + +G +
Sbjct: 279 NISFRDSSSLGRFEITVGPKQTMGKTI--EGVTVTSQMPKGVLNMSLTPSQGTHTFDPVT 336
Query: 347 NAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEV-PFAPSGLKVRYLKVF 405
+ W + ++ K + + L K P I++ F++ A SGLKV L ++
Sbjct: 337 KMLSWDVGKINPQKLPSLKGTMS-LQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMY 395
Query: 406 EPKLNYSDHDVIKWVRYIGRSGIYETR 432
K + K ++Y+ ++G ++ R
Sbjct: 396 GEK-----YKPFKGIKYMTKAGKFQVR 417
>gi|21361863 stonin 2 [Homo sapiens]
Length = 905
Score = 75.9 bits (185), Expect = 7e-14
Identities = 78/309 (25%), Positives = 130/309 (42%), Gaps = 56/309 (18%)
Query: 163 GIKYRRNELFLDVLESVNLLMSP-QGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIE 221
G+ Y E+ +DV + + ++S Q+L HV R+ + S+LSG+ EC+ G+ND +V
Sbjct: 563 GLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKG 622
Query: 222 KQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDG-EFELMRYRTT-K 279
+ D + + I + +C FH CV F + R I F P D FELMR+RT
Sbjct: 623 NEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFA 682
Query: 280 DIILPFRVIPLVREVGRTKLEVKVVIK------SNFKP--SLLAQKIEVRIPTP------ 325
+ LPF + V ++EV+ ++ +N P + + + +R P P
Sbjct: 683 EKTLPF-TLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKN 741
Query: 326 ------------------------LNTSGVQVI--CMKGKAKYKASENAIVWKIKRMAGM 359
+ SG + + G AKY+ + N+IVW+I R+
Sbjct: 742 FRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDK 801
Query: 360 KESQ-----ISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSD 413
+ +EL + +++ F +P + S VR + V +
Sbjct: 802 NSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKT----- 856
Query: 414 HDVIKWVRY 422
DV KWV Y
Sbjct: 857 -DVRKWVNY 864
>gi|26787993 stonin 1 [Homo sapiens]
Length = 735
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/273 (23%), Positives = 122/273 (44%), Gaps = 51/273 (18%)
Query: 166 YRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGK 225
Y E+ L+++++ ++ +G+ + + V ++ +++G EC +ND + + K+ +
Sbjct: 410 YEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLND-LELPKRDE 468
Query: 226 GTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDG-EFELMRYRTT-KDIIL 283
++ S+ K+ I I D FH+CV + +F+ R I F+P D FELMR++T L
Sbjct: 469 SYYEKDSE--KKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNL 526
Query: 284 PFRVIPLVREVGRTKLEVKVVI-------KSNFKPSLLA-QKIEVRIPTP------LNTS 329
PF + +V G +E++ + +S++ SL + I + P P L T
Sbjct: 527 PFSLKSVVVVQG-AYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTM 585
Query: 330 GVQ--------------------------VICMKGKAKYKASENAIVWKIKRMAGMKESQ 363
+Q + G AKY+++ A+VWKI R+ S
Sbjct: 586 NLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSL 645
Query: 364 -----ISAEIELLPTNDKKKWARPPISMNFEVP 391
+S ++EL + P ++ F VP
Sbjct: 646 DHPHCLSYKLELGSDQEIPSDWYPFATVQFSVP 678
>gi|29553944 STON1-GTF2A1L protein [Homo sapiens]
Length = 1182
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/273 (23%), Positives = 122/273 (44%), Gaps = 51/273 (18%)
Query: 166 YRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGK 225
Y E+ L+++++ ++ +G+ + + V ++ +++G EC +ND + + K+ +
Sbjct: 410 YEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLND-LELPKRDE 468
Query: 226 GTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDG-EFELMRYRTT-KDIIL 283
++ S+ K+ I I D FH+CV + +F+ R I F+P D FELMR++T L
Sbjct: 469 SYYEKDSE--KKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNL 526
Query: 284 PFRVIPLVREVGRTKLEVKVVI-------KSNFKPSLLA-QKIEVRIPTP------LNTS 329
PF + +V G +E++ + +S++ SL + I + P P L T
Sbjct: 527 PFSLKSVVVVQG-AYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTM 585
Query: 330 GVQ--------------------------VICMKGKAKYKASENAIVWKIKRMAGMKESQ 363
+Q + G AKY+++ A+VWKI R+ S
Sbjct: 586 NLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSL 645
Query: 364 -----ISAEIELLPTNDKKKWARPPISMNFEVP 391
+S ++EL + P ++ F VP
Sbjct: 646 DHPHCLSYKLELGSDQEIPSDWYPFATVQFSVP 678
>gi|88703051 adaptor-related protein complex 1, sigma 3 subunit
[Homo sapiens]
Length = 154
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/147 (19%), Positives = 63/147 (42%), Gaps = 2/147 (1%)
Query: 1 MIGGLFIYNHKGEVLISRVY--RDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHV 58
MI + +++ +G++ + + Y D R + V +I +R S + +
Sbjct: 1 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK 60
Query: 59 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 118
+ ++++ + N + E +++ +++ YFG + E +I NF Y +LDE +
Sbjct: 61 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG 120
Query: 119 GYPQNSETGALKTFITQQGIKSQTKEE 145
G Q + I + +T EE
Sbjct: 121 GEIQETSKKIAVKAIEDSDMLQETMEE 147
>gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [Homo
sapiens]
Length = 158
Score = 37.7 bits (86), Expect = 0.020
Identities = 27/155 (17%), Positives = 67/155 (43%), Gaps = 2/155 (1%)
Query: 1 MIGGLFIYNHKGEVLISRVY--RDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHV 58
M+ + +++ +G++ + + Y D R + + V+ AR+ +
Sbjct: 1 MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYK 60
Query: 59 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 118
+ ++++ + N + E +++ +++ YFG + E +I NF Y +LDE L
Sbjct: 61 RYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMG 120
Query: 119 GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQV 153
G Q++ ++ I Q + + E + ++
Sbjct: 121 GDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEM 155
>gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [Homo
sapiens]
Length = 157
Score = 37.0 bits (84), Expect = 0.035
Identities = 25/151 (16%), Positives = 62/151 (41%), Gaps = 2/151 (1%)
Query: 5 LFIYNHKGEVLISRVY--RDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSN 62
+ +++ +G++ + + Y D + + V + AR+ + + ++
Sbjct: 4 MLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYAS 63
Query: 63 IWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQ 122
++ + N + E +++ +++ YFG + E +I NF Y +LDE L G Q
Sbjct: 64 LYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQ 123
Query: 123 NSETGALKTFITQQGIKSQTKEEQSQITSQV 153
+ + I Q + + E + ++
Sbjct: 124 ETSKKNVLKAIEQADLLQEEAETPRSVLEEI 154
>gi|70906430 adaptor-related protein complex 2, sigma 1 subunit
isoform AP17 [Homo sapiens]
Length = 142
Score = 36.6 bits (83), Expect = 0.046
Identities = 28/143 (19%), Positives = 59/143 (41%), Gaps = 5/143 (3%)
Query: 1 MIGGLFIYNHKGEVLISRVYR---DDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFH 57
MI + I N G+ +++ Y DD + ++ V+ R + +
Sbjct: 1 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHA-VVTVRDAKHTNFVEFRNFKIIY 59
Query: 58 VKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILD 117
+ + ++ N N E ++ +V+ YF + E ++ NF +Y ++DE+
Sbjct: 60 RRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFL 119
Query: 118 FG-YPQNSETGALKTFITQQGIK 139
G + S+T LK + Q ++
Sbjct: 120 AGEIRETSQTKVLKQLLMLQSLE 142
>gi|189409104 adaptor-related protein complex 4, sigma 1 subunit
isoform 2 [Homo sapiens]
Length = 144
Score = 35.4 bits (80), Expect = 0.10
Identities = 23/118 (19%), Positives = 53/118 (44%), Gaps = 2/118 (1%)
Query: 1 MIGGLFIYNHKGEVLISRVYRD-DIG-RNAVDAFRVNVIHARQQVRSPVTNIARTSFFHV 58
MI + N +G+ +S+ Y DI R ++ + +R + +
Sbjct: 1 MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYR 60
Query: 59 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEIL 116
+ + +++ N ++EF++ +V+ YF ++SE +I N ++ +LDE++
Sbjct: 61 QYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMV 118
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 34.7 bits (78), Expect = 0.17
Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 15/124 (12%)
Query: 69 TKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGA 128
TK N+ F++ + D I E+ KNN + +LD +LD GY G
Sbjct: 3 TKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLD-GYDNRLRPGL 61
Query: 129 --------LKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVN 180
++T G S T E T V + W+ E +K++ +++L N
Sbjct: 62 GDSITEVFTNIYVTSFGPVSDTDME---YTIDVFFRQKWKDERLKFKGP---MNILRLNN 115
Query: 181 LLMS 184
L+ S
Sbjct: 116 LMAS 119
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 34.7 bits (78), Expect = 0.17
Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 15/124 (12%)
Query: 69 TKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGA 128
TK N+ F++ + D I E+ KNN + +LD +LD GY G
Sbjct: 3 TKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLD-GYDNRLRPGL 61
Query: 129 --------LKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVN 180
++T G S T E T V + W+ E +K++ +++L N
Sbjct: 62 GDSITEVFTNIYVTSFGPVSDTDME---YTIDVFFRQKWKDERLKFKGP---MNILRLNN 115
Query: 181 LLMS 184
L+ S
Sbjct: 116 LMAS 119
>gi|131889097 cancer susceptibility candidate 1 isoform b [Homo
sapiens]
Length = 716
Score = 32.0 bits (71), Expect = 1.1
Identities = 42/185 (22%), Positives = 75/185 (40%), Gaps = 21/185 (11%)
Query: 99 ENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIG 158
E +K L+ + I G P S + TFI S KE+ ++ +V
Sbjct: 83 EKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFI------SLWKEKTNETFEEVI---- 132
Query: 159 WRREGIKYRRNELFLDVLESVN--LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMND 216
++++ L+++E + LL +P + ++ L + KFG+
Sbjct: 133 --------EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVAT 184
Query: 217 KIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYR 276
+I++ KQ AD S + ++ I ++ T + L K RS+ F FE+ R
Sbjct: 185 EILL-KQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRIL 243
Query: 277 TTKDI 281
T DI
Sbjct: 244 ATSDI 248
>gi|131889447 cancer susceptibility candidate 1 isoform c [Homo
sapiens]
Length = 690
Score = 32.0 bits (71), Expect = 1.1
Identities = 42/185 (22%), Positives = 75/185 (40%), Gaps = 21/185 (11%)
Query: 99 ENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIG 158
E +K L+ + I G P S + TFI S KE+ ++ +V
Sbjct: 147 EKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFI------SLWKEKTNETFEEVI---- 196
Query: 159 WRREGIKYRRNELFLDVLESVN--LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMND 216
++++ L+++E + LL +P + ++ L + KFG+
Sbjct: 197 --------EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVAT 248
Query: 217 KIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYR 276
+I++ KQ AD S + ++ I ++ T + L K RS+ F FE+ R
Sbjct: 249 EILL-KQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRIL 307
Query: 277 TTKDI 281
T DI
Sbjct: 308 ATSDI 312
>gi|131888105 cancer susceptibility candidate 1 isoform a [Homo
sapiens]
Length = 722
Score = 32.0 bits (71), Expect = 1.1
Identities = 42/185 (22%), Positives = 75/185 (40%), Gaps = 21/185 (11%)
Query: 99 ENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIG 158
E +K L+ + I G P S + TFI S KE+ ++ +V
Sbjct: 89 EKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFI------SLWKEKTNETFEEVI---- 138
Query: 159 WRREGIKYRRNELFLDVLESVN--LLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMND 216
++++ L+++E + LL +P + ++ L + KFG+
Sbjct: 139 --------EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVAT 190
Query: 217 KIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYR 276
+I++ KQ AD S + ++ I ++ T + L K RS+ F FE+ R
Sbjct: 191 EILL-KQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRIL 249
Query: 277 TTKDI 281
T DI
Sbjct: 250 ATSDI 254
>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
Length = 692
Score = 30.8 bits (68), Expect = 2.5
Identities = 21/86 (24%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query: 216 DKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRY 275
D + Q + S +G + +DD F RL + D +R+ F G F+ +
Sbjct: 147 DMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGL-- 204
Query: 276 RTTKDIILPFRVIPLVREVGRTKLEV 301
+ + L F +P + + G T+L V
Sbjct: 205 AELRHLNLAFNNLPCIVDFGLTRLRV 230
>gi|11863154 archain isoform 1 [Homo sapiens]
Length = 511
Score = 30.4 bits (67), Expect = 3.3
Identities = 17/70 (24%), Positives = 30/70 (42%)
Query: 63 IWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQ 122
+++ +T +N N E L V+ Y + E I + + DEI+ GY +
Sbjct: 64 LYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRE 123
Query: 123 NSETGALKTF 132
N ++TF
Sbjct: 124 NVNLAQIRTF 133
>gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide 1
[Homo sapiens]
Length = 462
Score = 30.0 bits (66), Expect = 4.3
Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 23/119 (19%)
Query: 99 ENIKNNFVLIYELLDEILD--FGYPQNSET-------GALKTFITQQGIKSQTKEEQSQI 149
+++K+NF L+ +L +E+LD YP+ G +TQ + S +++Q I
Sbjct: 133 DSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVI 192
Query: 150 TSQVTGQIGWRREG------------IKYRRNELFLDVLESV--NLLMSPQGQVLSAHV 194
Q W G + ++ E L LESV N++ +G+ S H+
Sbjct: 193 RFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIKERKGRNFSQHI 251
>gi|29150261 interferon, gamma-inducible protein 30 preproprotein
[Homo sapiens]
Length = 250
Score = 29.6 bits (65), Expect = 5.6
Identities = 30/112 (26%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 114 EILDF---GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNE 170
+ LDF G P N +TG L +G ++ +T G R +
Sbjct: 30 QALDFFGNGPPVNYKTGNLYL----RGPLKKSNAPLVNVTLYYEALCGGCRAFLIRELFP 85
Query: 171 LFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEK 222
+L V+E +N+ + P G +VSGR K G ECKF + V+++
Sbjct: 86 TWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQ-HGEEECKFNKVEACVLDE 136
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 29.3 bits (64), Expect = 7.3
Identities = 15/58 (25%), Positives = 27/58 (46%)
Query: 354 KRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNY 411
K A +E Q+ ++ ++ ++W M F +A K R++K+F P NY
Sbjct: 452 KLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNY 509
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,787,442
Number of Sequences: 37866
Number of extensions: 608713
Number of successful extensions: 1292
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1229
Number of HSP's gapped (non-prelim): 31
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.