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Search of human proteins with 68509921
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide
6 isoform 2 [Homo sapiens]
(446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ... 904 0.0
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ... 880 0.0
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 316 2e-86
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 302 4e-82
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 293 3e-79
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 291 6e-79
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 290 1e-78
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 288 7e-78
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 288 9e-78
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ... 286 3e-77
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 286 3e-77
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 283 2e-76
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ... 281 1e-75
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 281 1e-75
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 265 8e-71
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 263 2e-70
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 255 6e-68
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 248 8e-66
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 241 1e-63
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide... 214 1e-55
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1... 209 4e-54
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ... 184 2e-46
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 159 4e-39
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 151 1e-36
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 144 1e-34
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 100 3e-21
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 97 4e-20
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 94 2e-19
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 94 3e-19
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 93 4e-19
>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 2 [Homo sapiens]
Length = 446
Score = 904 bits (2337), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
Sbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRP 120
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRP
Sbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRP 120
Query: 121 FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL 180
FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL
Sbjct: 121 FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL 180
Query: 181 HIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN 240
HIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN
Sbjct: 181 HIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN 240
Query: 241 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 300
DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA
Sbjct: 241 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 300
Query: 301 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 360
HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK
Sbjct: 301 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 360
Query: 361 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420
PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG
Sbjct: 361 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420
Query: 421 QPRPSHHGVFAFLVTPSPYELCAVPR 446
QPRPSHHGVFAFLVTPSPYELCAVPR
Sbjct: 421 QPRPSHHGVFAFLVTPSPYELCAVPR 446
>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 1 [Homo sapiens]
Length = 497
Score = 880 bits (2275), Expect = 0.0
Identities = 446/497 (89%), Positives = 446/497 (89%), Gaps = 51/497 (10%)
Query: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
Sbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQG-- 118
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQG
Sbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
Query: 119 -------------------------------------------------RPFRPNGLLDK 129
RPFRPNGLLDK
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
Query: 130 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 189
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
Query: 190 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 249
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA
Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVA 300
Query: 250 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 309
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
Query: 310 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 369
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
Sbjct: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
Query: 370 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 429
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
Query: 430 FAFLVTPSPYELCAVPR 446
FAFLVTPSPYELCAVPR
Sbjct: 481 FAFLVTPSPYELCAVPR 497
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 316 bits (810), Expect = 2e-86
Identities = 184/479 (38%), Positives = 263/479 (54%), Gaps = 53/479 (11%)
Query: 16 FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAW 75
FLL D + RR+ YPPGP LP LGN VDF+ + +++G++FSL+L
Sbjct: 28 FLLAADFLKRRR--PKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGD 85
Query: 76 TPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL------------------------- 110
V++ GL ++EAL+ ++ +RP P+ + +
Sbjct: 86 ISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTAL 145
Query: 111 ---GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 148
G G +S G+PF P+ ++ AVSN+I S+T G RFEY D
Sbjct: 146 RNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
Query: 149 PRFLRLLDLAQEGLKEESGFLREVLNAVP-VLLHIPALAGKVLRFQKAFLTQLDELLTEH 207
F +LL L E E+ ++ N P ++ +P + K + ++ +H
Sbjct: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKH 265
Query: 208 RMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGL 267
R W+PA+ RD +A+L EM K GNP SSF++ENL DLF AG TTSTTL W L
Sbjct: 266 RKDWNPAET-RDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWAL 324
Query: 268 LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMT 327
L M L+P++Q +VQ EID VIGQ ++P + MPYT AVIHEVQR G+I+PL V
Sbjct: 325 LYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREV 384
Query: 328 SRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA 387
+ D + G+ +PKGT ++TNL+++ +D W P F+P+HFL+ G F K EAF+PFS
Sbjct: 385 TVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSI 443
Query: 388 GRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 446
G+RACLGE LAR ELF+FFTSL+Q F+F P + + S ++P + LCAVP+
Sbjct: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNE-KLSLKFRMGITISPVSHRLCAVPQ 501
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 302 bits (774), Expect = 4e-82
Identities = 183/484 (37%), Positives = 262/484 (54%), Gaps = 51/484 (10%)
Query: 11 VIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFS 70
V+ F+LL L + R + PPGP PLP +GN+L +D ++ F + +G VF+
Sbjct: 8 VLCLSFMLLFSLWRQSCR-RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66
Query: 71 LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL-------------------- 110
+ P+VV +G AV+EAL+ +GE+ + R PI+Q +
Sbjct: 67 VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRF 126
Query: 111 --------GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCGRR 143
G G RS + P P +L A NVI S+ +R
Sbjct: 127 SLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186
Query: 144 FEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLTQLDE 202
F+Y D FL L+ E + + +V N P+L+ P KVL+ + + E
Sbjct: 187 FDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIRE 246
Query: 203 LLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTT 262
+ EH+ + D PRD + FL +ME+ K N +S FN ENL VADLF AG TTSTT
Sbjct: 247 KVKEHQASLD-VNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305
Query: 263 LAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG 322
L +GLLL++ HP+V +VQ+EID VIG+ R P M D++HMPYT AV+HE+QR+ D+VP G
Sbjct: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365
Query: 323 VTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAF 382
V H + D + + + IPKGTT++ L+SVL D+ + P F P HFLD G+F K + F
Sbjct: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425
Query: 383 LPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVT-PSPYEL 441
+PFSAG+R C GE LARMELFLF T++LQ+F+ + V +V+ P Y++
Sbjct: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQI 485
Query: 442 CAVP 445
C +P
Sbjct: 486 CFIP 489
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 293 bits (749), Expect = 3e-79
Identities = 182/493 (36%), Positives = 265/493 (53%), Gaps = 59/493 (11%)
Query: 7 VPLAVIV-AIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
V +A++V A FLLLV M R+ + PPGP PLP +GNL ++ +N P F +L +RF
Sbjct: 6 VTVALLVWAAFLLLVS-MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRF 64
Query: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP-------------------- 105
G VF+L + +VV++G AV+EAL+ + ++ + R +P
Sbjct: 65 GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKD 124
Query: 106 -----ITQILGFGP---------------------RSQGRPFRPNGLLDKAVSNVIASLT 139
+T + +G ++QG+PF P L+ A NVIA +
Sbjct: 125 IRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADIL 184
Query: 140 CGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLT 198
+ F+Y+D +FLRL+ L E S ++ N P LH +P KV++
Sbjct: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244
Query: 199 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVT 258
+ E + EH + DP PRDLT+ L EMEK K + E + + + + VADLF AG T
Sbjct: 245 YVSERVKEHHQSLDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTET 303
Query: 259 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 318
TSTTL +GLL+++ +P+++ ++ +EID VIG R P + D+ MPY AV+HE+QRF +
Sbjct: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363
Query: 319 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 378
VP + H +RD +G+ IPKGT ++ L SVL D + P +F PEHFL+ G F
Sbjct: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 423
Query: 379 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFL 433
+ F PFS G+R C GE LARMELFL ++LQHF+ P P+ P H G F
Sbjct: 424 SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK-PLVDPKDIDLSPIHIG---FG 479
Query: 434 VTPSPYELCAVPR 446
P Y+LC +PR
Sbjct: 480 CIPPRYKLCVIPR 492
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 291 bits (746), Expect = 6e-79
Identities = 174/486 (35%), Positives = 260/486 (53%), Gaps = 50/486 (10%)
Query: 9 LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
+ +++ + LL+ + R+ + PPGP PLP +GN+L +D ++ L + +G V
Sbjct: 5 VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
Query: 69 FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQI------------------- 109
F+L +VVL+G V+EAL+ GE+ + R P+ +
Sbjct: 65 FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
Query: 110 ---------LGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCG 141
G G RS + P P +L A NVI S+
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
Query: 142 RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQL 200
+RF+Y D +FL L++ E ++ S ++ N P ++ + P K+L+ + +
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
Query: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260
E + EH+ + D PRD + FL +MEK K N +S F ENL I ADL AG TTS
Sbjct: 245 LEKVKEHQESMD-INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303
Query: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320
TTL + LLL++ HP+V +VQ+EI+ VIG+ R P M D+ HMPYT AV+HEVQR+ D++P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363
Query: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380
+ H + D++ + + IPKGTT++T+L+SVL D + P F P HFLD G+F K
Sbjct: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423
Query: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVTPSPY 439
F+PFSAG+R C+GE LARMELFLF T +LQ+F+ S+ + + V F P Y
Sbjct: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFY 483
Query: 440 ELCAVP 445
+LC +P
Sbjct: 484 QLCFIP 489
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 290 bits (743), Expect = 1e-78
Identities = 183/498 (36%), Positives = 259/498 (52%), Gaps = 59/498 (11%)
Query: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
M L L+ LA++ + LLLV R R PPGP PLP LGNLL +D + F +
Sbjct: 1 MELSVLLFLALLTGLLLLLVQ---RHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP--------------- 105
R ++GDVF++ L PVV+L G+ A+REALV E + R +
Sbjct: 58 FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
Query: 106 -----------ITQILGFGP---------------------RSQGRPFRPNGLLDKAVSN 133
+T + FG +S+G P L +N
Sbjct: 118 GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITAN 177
Query: 134 VIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRF 192
+I S+ G+RF Y D FL++L+L + S ++ L + P +V +
Sbjct: 178 IICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN 237
Query: 193 QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLF 252
+ + + +HR T DP+ P +DL + +L MEK K N S F+ +NL + LF
Sbjct: 238 LQEINAYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296
Query: 253 SAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEV 312
AG TTSTTL +G LLM+ +P V RV +EI+ VIG R PE+ D+A MPYT AVI+E+
Sbjct: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356
Query: 313 QRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDA 372
QRF D++P+GV H+ ++ +G+ IPK T + LS+ L D +EKP F+P+HFLDA
Sbjct: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416
Query: 373 QGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP----RPSHHG 428
G K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+FS + P P G
Sbjct: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476
Query: 429 VFAFLVTPSPYELCAVPR 446
V P Y++ +PR
Sbjct: 477 VGKI---PPTYQIRFLPR 491
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 288 bits (737), Expect = 7e-78
Identities = 173/489 (35%), Positives = 262/489 (53%), Gaps = 56/489 (11%)
Query: 9 LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
+A+++ + L + + R+ R P GP PLP +GN+L +D ++ + +G V
Sbjct: 5 VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
Query: 69 FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL------------------ 110
F++ P+VVL+G AV+EAL+ HGE+ + R P+ + +
Sbjct: 65 FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
Query: 111 ----------GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCG 141
G G RS P P +L A NVI S+
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
Query: 142 RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQL 200
RF+Y D RFL L++ E L+ S +V N P L+ ++P K+ + +
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
Query: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260
E + EH+ + D RD + FL +ME+ K N +S F E+L V D+F AG TTS
Sbjct: 245 LERIKEHQESLD-MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTS 303
Query: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320
TTL +GLLL++ +P+V +VQ+EI+ V+G+ R P M D++HMPYT AV+HE+QR+ D++P
Sbjct: 304 TTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLP 363
Query: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380
+ H + D++ + + IPKGTT+IT+L+SVL ++ + P F P HFLD G+F K +
Sbjct: 364 TNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSD 423
Query: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVF----AFLVTP 436
F+PFSAG+R C+GE LARMELFLF T++LQ+F+ Q P + AF P
Sbjct: 424 YFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPKDIDITPIANAFGRVP 480
Query: 437 SPYELCAVP 445
Y+LC +P
Sbjct: 481 PLYQLCFIP 489
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 288 bits (736), Expect = 9e-78
Identities = 177/492 (35%), Positives = 265/492 (53%), Gaps = 52/492 (10%)
Query: 3 LEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLR 62
+++LV L + ++ LLL + R+ + PPGP PLP +GN+L + ++ L
Sbjct: 1 MDSLVVLVLCLSCLLLLS--LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLS 58
Query: 63 RRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQI------------- 109
+ +G VF+L P+VVL+G AV+EAL+ GE+ + R P+ +
Sbjct: 59 KVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGK 118
Query: 110 ---------------LGFGPRS-------------------QGRPFRPNGLLDKAVSNVI 135
G G RS + P P +L A NVI
Sbjct: 119 KWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVI 178
Query: 136 ASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLLHIPALAGKVLRFQK 194
S+ +RF+Y D +FL L++ E +K S +++ N P++ + P K+L+
Sbjct: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA 238
Query: 195 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSA 254
+ + E + EH+ + D P+D + FL +MEK K N S F E+L DLF A
Sbjct: 239 FMKSYILEKVKEHQESMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297
Query: 255 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR 314
G TTSTTL + LLL++ HP+V +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR
Sbjct: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357
Query: 315 FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 374
+ D++P + H + DI+ + + IPKGTT++ +L+SVL D + P F P HFLD G
Sbjct: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG 417
Query: 375 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFL 433
+F K + F+PFSAG+R C+GE LA MELFLF TS+LQ+F+ S+ + + V F
Sbjct: 418 NFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFA 477
Query: 434 VTPSPYELCAVP 445
P Y+LC +P
Sbjct: 478 SVPPFYQLCFIP 489
>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
[Homo sapiens]
Length = 491
Score = 286 bits (731), Expect = 3e-77
Identities = 181/493 (36%), Positives = 260/493 (52%), Gaps = 58/493 (11%)
Query: 7 VPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66
+ A+++ + L+ L+ R + PPGP PL LGNLL + Q+ +L + +G
Sbjct: 4 ISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63
Query: 67 DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP--------------------- 105
++++ L VVVL+G AV+EALV GE+ + R P
Sbjct: 64 SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123
Query: 106 -------ITQILGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLT 139
I + G G RS +G PF P +L ++VSN+I S+
Sbjct: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
Query: 140 CGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLT 198
G RF+YDD R L ++ L + + S E+ + P LL +P ++ + K
Sbjct: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
Query: 199 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVT 258
+ + +H+ + DP + PRD + FL +M + K +P S F+ + L + +L G T
Sbjct: 244 LIAHSVHDHQASLDP-RSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKT 302
Query: 259 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 318
STTL L ++ +P VQ RVQ+EID V+G+ R P + D+A MPYT AVIHEVQRF DI
Sbjct: 303 VSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADI 362
Query: 319 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 378
+P+ + H +RD +GF IPKGT +IT L++V D + + P F+PEHFLDA F K
Sbjct: 363 IPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKK 422
Query: 379 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFL 433
AF+PFSAGRR CLGE LARMELFL+ T++LQ FS P G P P G+
Sbjct: 423 SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQ-PLGAPEDIDLTPLSSGLGNL- 480
Query: 434 VTPSPYELCAVPR 446
P P++LC PR
Sbjct: 481 --PRPFQLCLRPR 491
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 286 bits (731), Expect = 3e-77
Identities = 182/486 (37%), Positives = 253/486 (52%), Gaps = 54/486 (11%)
Query: 14 AIFLLLVDLMHR---RQRWAARYPPGPLPLPGLGNLLHVDFQNT-PYCFDQLRRR-FGDV 68
A+FLLL L R +QR +PPGP LP +GN+ + + P+ + + + + +G++
Sbjct: 17 ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76
Query: 69 FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIT--------------------- 107
FSL L VVLNG V+E LV E ADRP +P+
Sbjct: 77 FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136
Query: 108 --------QILGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTC 140
+ G+G +S +GRPF L+ AVSN+ +
Sbjct: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196
Query: 141 GRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQL 200
G RF Y+D F +++L E ++ + + NA P + +P + L A +
Sbjct: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256
Query: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260
L E Q P+ +A+L EM++ K +P S+F+ ENL V +L AG TT+
Sbjct: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316
Query: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320
L W +L M L+P++Q +VQ+EID ++G +P D+ MPYT AV+HEV RF +IVP
Sbjct: 317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVP 376
Query: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380
LG+ H TS D V+G+ IPKGTT+ITNL SV DE W P FHPE FLD+ G+F K E
Sbjct: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436
Query: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYE 440
A +PFS GRR CLGE LARME+FLFFT+LLQ F P + P + P PY
Sbjct: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP-HELVPDLKPRLGMTLQPQPYL 495
Query: 441 LCAVPR 446
+CA R
Sbjct: 496 ICAERR 501
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 283 bits (724), Expect = 2e-76
Identities = 183/516 (35%), Positives = 262/516 (50%), Gaps = 76/516 (14%)
Query: 1 MGLEALVPL--AVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHV--------- 49
+GL L P A+++ + L+ R+R A PPGP P P +GN HV
Sbjct: 25 LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84
Query: 50 --------------DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHG 95
L R +G +FS + VVVL+ +VREALV
Sbjct: 85 SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144
Query: 96 EDTADRPPVPITQILG---------FGP--RSQGR------------------------- 119
E +DRP VP+ I+ +GP R Q +
Sbjct: 145 EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFK 204
Query: 120 ------------PFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG 167
PF P ++ AVSN+I SL G+RF+Y + F ++L GL+
Sbjct: 205 YVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLN 264
Query: 168 FLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLA 226
++N P L ++P K LR +K + L +++ +H+ + D + P+D + +L
Sbjct: 265 SQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLD-RENPQDFIDMYLL 323
Query: 227 EMEKA-KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID 285
ME+ K N SSF++E L ++ DLF AG TT+ +L W LL M L+PDVQ +V +EI+
Sbjct: 324 HMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIE 383
Query: 286 DVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLI 345
VIG R P + D+A MPYT A I EVQR +VPL + HMTS + +QG+ IPKGT ++
Sbjct: 384 RVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLIL 443
Query: 346 TNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLF 405
NL SV +D A+WEKP F+P FLD QG +K E F+PF G+R C+GE LA+MELFL
Sbjct: 444 PNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLM 503
Query: 406 FTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYEL 441
F SL+Q F+F++P +P G F + P P+ +
Sbjct: 504 FVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNI 539
>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
[Homo sapiens]
Length = 494
Score = 281 bits (718), Expect = 1e-75
Identities = 174/495 (35%), Positives = 260/495 (52%), Gaps = 62/495 (12%)
Query: 6 LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
LV L + + +L+ R+ R + PPGP PLP +GN L ++ + ++ R+
Sbjct: 8 LVTLLACLTVMVLMSVWRQRKSR--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
Query: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103
G VF++ L VVVL G AV+EALV E+ + R
Sbjct: 66 GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAK 125
Query: 104 ----VPITQILGFGPRSQGRPFR---------------------PNGLLDKAVSNVIASL 138
I + GFG +G R P L + VSNVI+S+
Sbjct: 126 QLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSI 185
Query: 139 TCGRRFEYDDPRFLRLLDLAQEGLK---EESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195
G RF+Y+D FL LL + + +G L E+ ++V + H+P + + +
Sbjct: 186 VFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSV--MKHLPGPQQQAFKELQG 243
Query: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255
+ + + ++ T DP PRD ++FL M++ + NP + F +NL + +LF AG
Sbjct: 244 LEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAG 302
Query: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315
T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+ D+A MPYT AVIHE+QRF
Sbjct: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRF 362
Query: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375
GD++P+G+ H ++D + + F +PKGT + L SVL+D + P F+P+HFLD +G
Sbjct: 363 GDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQ 422
Query: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFA 431
F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F F P P H G
Sbjct: 423 FKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVG--- 479
Query: 432 FLVTPSPYELCAVPR 446
F P Y + +PR
Sbjct: 480 FATIPRNYTMSFLPR 494
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 281 bits (718), Expect = 1e-75
Identities = 187/466 (40%), Positives = 237/466 (50%), Gaps = 53/466 (11%)
Query: 30 AARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVRE 89
AAR+PPGP PLP +GNL + +L R+G VF++ L VVL G AV+E
Sbjct: 28 AARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKE 87
Query: 90 ALVTHGEDTADRPPVPITQI----------------------------LGFGPRS----- 116
AL G++ ADRPP+ I Q+ LG G
Sbjct: 88 ALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKI 147
Query: 117 --------------QGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGL 162
+GRPF P LL A SN+ +L GRRF+Y DP F+ LL L E +
Sbjct: 148 LQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVM 206
Query: 163 KEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTE 222
++ N P L + L VLR + L LL R P P +
Sbjct: 207 VLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVD 266
Query: 223 AFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 282
A + + + +PE F + N D+ AG TTS TL W LLM HPDVQ RVQ+
Sbjct: 267 ALIQQGQG--DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQE 324
Query: 283 EIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGT 342
E+D V+G R P + DQ +PYT+AV+HEVQRF ++P V T+ D ++ GF +PKGT
Sbjct: 325 ELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGT 383
Query: 343 TLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMEL 402
+I L+SVL DE W+ P +F+P HFLDA GHFVK EAFLPFSAGRR C+GE LAR EL
Sbjct: 384 PVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTEL 443
Query: 403 FLFFTSLLQHFSFSVPTGQPRPS--HHGVFAFLVTPSPYELCAVPR 446
FL F LLQ + P G S AF + P LCAVPR
Sbjct: 444 FLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 265 bits (676), Expect = 8e-71
Identities = 168/495 (33%), Positives = 255/495 (51%), Gaps = 62/495 (12%)
Query: 6 LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
LV L V + + +L+ R+ + + PPGP PLP +GN L ++ + ++ R+
Sbjct: 8 LVALLVCLTVMVLMSVWQQRKSK--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
Query: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103
G VF++ L VVVL G AVREALV E+ + R
Sbjct: 66 GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAK 125
Query: 104 ------VPITQILGFGPR-------------------SQGRPFRPNGLLDKAVSNVIASL 138
+ + G G R + G P L + VSNVI+S+
Sbjct: 126 QLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSI 185
Query: 139 TCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195
G RF+Y D FL LL + + +G L E+ ++V + H+P + + +
Sbjct: 186 VFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFQLLQG 243
Query: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255
+ + + ++ T DP PRD ++FL M++ + NP + F +NL + +LF G
Sbjct: 244 LEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGG 302
Query: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315
T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+ D+A MPY AVIHE+QRF
Sbjct: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRF 362
Query: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375
GD++P+ + +D + + F +PKGT + L SVL+D + + P F+P+HFL+ +G
Sbjct: 363 GDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ 422
Query: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF----SFSVPTGQPRPSHHGVFA 431
F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F S S P H G
Sbjct: 423 FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVG--- 479
Query: 432 FLVTPSPYELCAVPR 446
F P Y + +PR
Sbjct: 480 FATIPRNYTMSFLPR 494
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 263 bits (672), Expect = 2e-70
Identities = 167/494 (33%), Positives = 255/494 (51%), Gaps = 60/494 (12%)
Query: 6 LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
LV L + + +L+ R+ R + PPGP PLP +GN L ++ ++ + +
Sbjct: 8 LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65
Query: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103
G VF++ L VVVL G AVREALV E+ + R
Sbjct: 66 GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAK 125
Query: 104 ------VPITQILGFGPR-------------------SQGRPFRPNGLLDKAVSNVIASL 138
+ + G G R + G P L + VSNVI+S+
Sbjct: 126 QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 185
Query: 139 TCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195
G RF+Y+D FL LL + + +G L E+ ++V + H+P + + +
Sbjct: 186 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFKLLQG 243
Query: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255
+ + + ++ T DP P+D ++FL M++ + NP + F +NL + +LF AG
Sbjct: 244 LEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAG 302
Query: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315
T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+ D+ MPY AVIHE+QRF
Sbjct: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRF 362
Query: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375
GD++P+ + +D + + F +PKGT + L SVL+D + + P F+P+HFLD +G
Sbjct: 363 GDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQ 422
Query: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHGVFAF 432
F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F S P H VFA
Sbjct: 423 FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFAT 482
Query: 433 LVTPSPYELCAVPR 446
+ P Y + +PR
Sbjct: 483 I--PRNYTMSFLPR 494
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 255 bits (651), Expect = 6e-68
Identities = 172/499 (34%), Positives = 257/499 (51%), Gaps = 62/499 (12%)
Query: 3 LEALVPLAVIVAI-FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 61
+EA A+++A+ LLL+ L R PPGP PLP LGNLL + +L
Sbjct: 1 MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60
Query: 62 RRRFGDVFSLQLA-WTPVVVLNGLAAVREALVTHGEDTADRPPVPITQ------------ 108
+++G VF++ L W PVVVL G AVREAL E+ + R V + +
Sbjct: 61 SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120
Query: 109 ----------------ILGFGPR-------------------SQGRPFRPNGLLDKAVSN 133
LG G R ++GRPF P+ LL +A SN
Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
Query: 134 VIASLTCGRRFEYDDPRFLRLLDLAQE---GLKEESGFLREVLNAVPVLLHIPALAGKVL 190
V+ SL G RF Y+D F ++ A G+ + G E+ + L +P ++L
Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLL 238
Query: 191 RFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVAD 250
+ +H+ D + P RDL +AFL +M + + NP + F ++N+ + V
Sbjct: 239 HHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIY 298
Query: 251 LFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH 310
L AG +T STT+ + LLL++ +P VQ+ V++E++ +G + P +GD+ +PYT AV+H
Sbjct: 299 LLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLH 358
Query: 311 EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 370
E QR +VP+G+ R +G+ +P+GT + L S+L D +++ P F+P+ FL
Sbjct: 359 EAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418
Query: 371 DAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP----TGQPRPSH 426
DA G F K EAFLPFS G+R CLGE LA+ ELFLFFT++LQ FS P T +P+
Sbjct: 419 DADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTV 478
Query: 427 HGVF----AFLVTPSPYEL 441
G+F AF + P +L
Sbjct: 479 SGLFNIPPAFQLQVRPTDL 497
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 248 bits (633), Expect = 8e-66
Identities = 154/452 (34%), Positives = 242/452 (53%), Gaps = 27/452 (5%)
Query: 6 LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65
LV L + + +L+ R+ R + PPGP PLP +GN L ++ ++ C ++
Sbjct: 8 LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHI--CDSIMKVSQ 63
Query: 66 GDVFS-----LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRP 120
G FS QL + L + + ++ + I + G
Sbjct: 64 GVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRS-------THGAN 116
Query: 121 FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVP 177
P L + VSNVI+S+ G RF+Y+D FL LL + + +G L E+ ++V
Sbjct: 117 IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSV- 175
Query: 178 VLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPES 237
+ H+P + + + + + + ++ T DP P+D ++FL M++ + NP +
Sbjct: 176 -MKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNT 233
Query: 238 SFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG 297
F +NL + +LF AG T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+
Sbjct: 234 EFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFE 293
Query: 298 DQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV 357
D+ MPY AVIHE+QRFGD++P+ + +D + + F +PKGT + L SVL+D +
Sbjct: 294 DRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSF 353
Query: 358 WEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---S 414
+ P F+P+HFLD +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F S
Sbjct: 354 FSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS 413
Query: 415 FSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 446
P H VFA + P Y + +PR
Sbjct: 414 SQSPKDIDVSPKHVVFATI--PRNYTMSFLPR 443
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 241 bits (614), Expect = 1e-63
Identities = 151/447 (33%), Positives = 242/447 (54%), Gaps = 31/447 (6%)
Query: 9 LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68
+A+++ + L + + R+ R P GP PLP +GN+L +D ++ + +G V
Sbjct: 5 VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
Query: 69 FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR---SQGRPFRPNG 125
F++ P+VVL+G AV+EAL+ HGE+ + R P+ + + G S G+ ++
Sbjct: 65 FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKE-- 122
Query: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLRE---VLNAVPVLLHI 182
+ + + + G+R D R E L++ + + +L P +
Sbjct: 123 -IRRFCLMTLRNFGMGKRSIED--RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179
Query: 183 PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 242
+ ++ L E E+ R L+ ++ E K N +S F E
Sbjct: 180 SVIFHDRFDYKDQRFLNLMEKFNENL---------RILSSPWIQE----KHNQQSEFTVE 226
Query: 243 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 302
+L V D+F AG TTSTTL +GLLL++ +P+V +VQ+EI+ V+G+ R P M D++HM
Sbjct: 227 SLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHM 286
Query: 303 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 362
PYT AV+HE+QR+ D++P + H + D++ + + IPKGTT+IT+L+SVL ++ + P
Sbjct: 287 PYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPE 346
Query: 363 RFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP 422
F P HFLD G+F K + F+PFSAG+R C+GE LARMELFLF T++LQ+F+ Q
Sbjct: 347 MFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQV 403
Query: 423 RPSHHGVF----AFLVTPSPYELCAVP 445
P + AF P Y+LC +P
Sbjct: 404 DPKDIDITPIANAFGRVPPLYQLCFIP 430
>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
[Homo sapiens]
Length = 543
Score = 214 bits (545), Expect = 1e-55
Identities = 158/492 (32%), Positives = 222/492 (45%), Gaps = 79/492 (16%)
Query: 6 LVPLAVIVAIFLLLVD----------LMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTP 55
L PL++ LLL+ L+ +R+R PPGP P +GN V Q
Sbjct: 13 LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAH 71
Query: 56 YCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFG-- 113
F +L RR+GDVF ++L P+VVLNG A+ +ALV G ADRP +++ G
Sbjct: 72 LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRS 131
Query: 114 ----------------------------PRSQ------------------------GRPF 121
PRS+ G
Sbjct: 132 MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFL 191
Query: 122 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVLL 180
P L AV+NV++++ G R+ +DDP F LL +E G +G L +V+ P L
Sbjct: 192 DPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVM---PWLQ 248
Query: 181 HIPALAGKVLR----FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AKGNP 235
+ P V R + F + + H + P PRD+ +AF+ EK A G+
Sbjct: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308
Query: 236 ESS---FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 292
+ EN+ + D+F A T ST L W LLL +PDVQ RVQ E+D V+G+ R
Sbjct: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368
Query: 293 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 352
P MGDQ ++PY A ++E RF VP+ + H T+ + V G+ IPK T + N SV
Sbjct: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428
Query: 353 KDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLL 410
D W P F P FLD G K + FS G+R C+GE L++M+LFLF + L
Sbjct: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILA 488
Query: 411 QHFSFSVPTGQP 422
F +P
Sbjct: 489 HQCDFRANPNEP 500
>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
[Homo sapiens]
Length = 512
Score = 209 bits (532), Expect = 4e-54
Identities = 138/451 (30%), Positives = 222/451 (49%), Gaps = 69/451 (15%)
Query: 34 PPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93
PPGP P +G++L + +N ++ +++GDV +++ TPVVVL+GL +R+ALV
Sbjct: 40 PPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98
Query: 94 HGEDTADRPP------VPITQILGFGPRS-----QGRPFRPNGL---------------- 126
G+D RP + Q + F P S R NGL
Sbjct: 99 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158
Query: 127 LDKAVS-------------------------------NVIASLTCGRRFEYDDPRFLRLL 155
L++ VS NVI ++ GRR++++ L L+
Sbjct: 159 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV 218
Query: 156 DLAQE-GLKEESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDP 213
+L G SG + +P+L ++P + + + F + + +++ EH T++
Sbjct: 219 NLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275
Query: 214 AQPPRDLTEAFLAEMEKAK--GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMI 271
RD+T++ + ++ + N +DE + +V DLF AG T +T ++W L+ ++
Sbjct: 276 GH-IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334
Query: 272 LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI 331
++P VQR++Q+E+D VIG+ RRP + D++H+PY A I E R VP + H T+RD
Sbjct: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394
Query: 332 EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF--VKPEAFLPFSAGR 389
++GF IPKG + N + D+ +W P F PE FL G V E + F G+
Sbjct: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454
Query: 390 RACLGEPLARMELFLFFTSLLQHFSFSVPTG 420
R C+GE +AR E+FLF LLQ FSVP G
Sbjct: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLG 485
>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
[Homo sapiens]
Length = 516
Score = 184 bits (466), Expect = 2e-46
Identities = 141/479 (29%), Positives = 218/479 (45%), Gaps = 67/479 (13%)
Query: 4 EALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRR 63
E L+ A+ +F +L L R + + PP P P LG++L + +N ++ +
Sbjct: 13 ELLLASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQ 70
Query: 64 RFGDVFSLQLAWTPVVVLNGL-----AAVREA-------------LVTHGED---TADRP 102
R+GDV +++ TPV+VL+ L A VR+ L+T G+ + D
Sbjct: 71 RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSG 130
Query: 103 PVPI-----------TQILGFGPRSQGR--------------------------PFRPNG 125
PV T + P S F P
Sbjct: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190
Query: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPAL 185
+ +V+NVI ++ G+ F L L+ E ++ S L+ P+L ++P
Sbjct: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFPILRYLPNP 248
Query: 186 AGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL 244
A + + F + FL L + + EH +D RD+T A +K + E +
Sbjct: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDK-NSVRDITGALFKHSKKGPRASGNLIPQEKI 307
Query: 245 CIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY 304
+V D+F AG T +T ++W L+ ++ P++QR++Q+E+D VIG+ RRP + D+ +PY
Sbjct: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367
Query: 305 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRF 364
A I E R +P + H T+RD + GF IPK + N V D +WE P F
Sbjct: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427
Query: 365 HPEHFLDAQGHFV-KP--EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420
PE FL A G + KP E + F G+R C+GE LA+ E+FLF LLQ FSVP G
Sbjct: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 159 bits (403), Expect = 4e-39
Identities = 135/459 (29%), Positives = 206/459 (44%), Gaps = 82/459 (17%)
Query: 29 WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVR 88
W R P PG +LL D P L ++FG ++ L L VVVLN +
Sbjct: 23 WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIE 79
Query: 89 EALVTHGEDTADRPPVPITQ------------------------------ILG------- 111
EA+V D A RP P+T +LG
Sbjct: 80 EAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEP 138
Query: 112 --------FGPRSQGRPFRPNGLLDK---AVSNVIASLTCGRRFEYDD--PRFLRLLDLA 158
F R + +P P + ++ ++I LT G + + D+ P + + +
Sbjct: 139 VVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI--- 195
Query: 159 QEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDEL----LTEHRMTWDPA 214
QE LK S + ++++ +P L P LR K + + D + L +H+ +
Sbjct: 196 QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAG 252
Query: 215 QPPRDLTEAFLA-----EMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 269
Q RD+ + L ME+ G + ++ + DL G TT+ TL+W ++
Sbjct: 253 QW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTANTLSWAVVF 307
Query: 270 MILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHM 326
++ HP++Q+R+Q+E+D +G R D+A +P A I EV R +VPL + H
Sbjct: 308 LLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHR 367
Query: 327 TSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFS 386
T+R + G+ IP+GT +I NL DE VWE+P F P+ FL+ K L F
Sbjct: 368 TTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFG 423
Query: 387 AGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS 425
G R CLGEPLAR+ELF+ T LLQ F+ +P+G PS
Sbjct: 424 CGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS 461
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 151 bits (381), Expect = 1e-36
Identities = 126/430 (29%), Positives = 199/430 (46%), Gaps = 54/430 (12%)
Query: 29 WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAV- 87
W R P PG +LL D P L ++FG ++ L L +V +
Sbjct: 23 WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDKLVSRNYPDLS 79
Query: 88 ---------------REALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDK--- 129
R AL+ D+ + +TQ F R + +P P + ++
Sbjct: 80 LGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQ--EFCERMRAQPGTPVAIEEEFSL 137
Query: 130 AVSNVIASLTCGRRFEYDD--PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAG 187
++I LT G + + D+ P + + + QE LK S + ++++ +P L P
Sbjct: 138 LTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---N 191
Query: 188 KVLRFQKAFLTQLDEL----LTEHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESS 238
LR K + + D + L +H+ + Q RD+ + L ME+ G
Sbjct: 192 PGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ---- 246
Query: 239 FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPE 295
+ ++ + DL G TT+ TL+W ++ ++ HP++Q+R+Q+E+D +G R
Sbjct: 247 LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP 306
Query: 296 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 355
D+A +P A I EV R +VPL + H T+R + G+ IP+GT +I NL DE
Sbjct: 307 YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE 366
Query: 356 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 415
VWE+P F P+ FL+ K L F G R CLGEPLAR+ELF+ T LLQ F+
Sbjct: 367 TVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422
Query: 416 SVPTGQPRPS 425
+P+G PS
Sbjct: 423 -LPSGDALPS 431
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 144 bits (364), Expect = 1e-34
Identities = 122/483 (25%), Positives = 213/483 (44%), Gaps = 72/483 (14%)
Query: 12 IVAIFLLLVDLMH--RRQRWAARYPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRF 65
+VA+ LL + + +R+ A+YP L LP +G+L H N F +L++++
Sbjct: 4 LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKY 60
Query: 66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNG 125
G ++S+++ V++ +E L+ G+D + RP + I +G F +G
Sbjct: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIA--SNNRKGIAFADSG 118
Query: 126 L----------------------LDKAV-----------------------------SNV 134
L+K + +NV
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178
Query: 135 IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIP-ALAGKVLRFQ 193
I+ + ++ DP L ++ EG+ + +++ VP L P K+
Sbjct: 179 ISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHV 236
Query: 194 KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLCIVV 248
K L+++L ++ + L A+M GN P+ +D ++ +
Sbjct: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296
Query: 249 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 308
D+F AG+ TT++ + W L ++ +P V++++ +EID +G R P + D+ + A
Sbjct: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356
Query: 309 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 368
I EV R + P+ + H + D + F + KGT +I NL ++ +E W +P +F PE
Sbjct: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416
Query: 369 FLDAQG-HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 426
FL+ G + P ++LPF AG R+C+GE LAR ELFL LLQ F VP PS
Sbjct: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476
Query: 427 HGV 429
G+
Sbjct: 477 EGI 479
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 100 bits (248), Expect = 3e-21
Identities = 63/199 (31%), Positives = 96/199 (48%), Gaps = 2/199 (1%)
Query: 216 PPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPD 275
P ++ AFL + + + + E++ V G TT+ + W L L+ +P+
Sbjct: 291 PSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPE 350
Query: 276 VQRRVQQEIDDVIGQVRRPE-MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQ 334
VQ++V E+DDV G+ RP + D + Y VI E R VPL S D EV
Sbjct: 351 VQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVA 409
Query: 335 GFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLG 394
G+R+ KGT + ++ +D + P F PE F P A++PFSAG R C+G
Sbjct: 410 GYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIG 469
Query: 395 EPLARMELFLFFTSLLQHF 413
+ A ME + +L+HF
Sbjct: 470 QKFAVMEEKTILSCILRHF 488
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 96.7 bits (239), Expect = 4e-20
Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 19/273 (6%)
Query: 143 RFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDE 202
RF++ DP FL + FL +L +L+I +V F + + ++ E
Sbjct: 212 RFDFLDPFFLSITVFP---------FLIPILE----VLNICVFPREVTNFLRKSVKRMKE 258
Query: 203 LLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTT 262
E D + D + + + + +D L AG TTS+
Sbjct: 259 SRLE-----DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313
Query: 263 LAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG 322
L++ + + HPDVQ+++Q+EID V+ P M Y V++E R I +
Sbjct: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MR 372
Query: 323 VTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAF 382
+ + +D+E+ G IPKG ++ ++ +D W +P +F PE F + P +
Sbjct: 373 LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432
Query: 383 LPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 415
PF +G R C+G A M + L +LQ+FSF
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465
Score = 33.1 bits (74), Expect = 0.52
Identities = 31/126 (24%), Positives = 52/126 (41%), Gaps = 21/126 (16%)
Query: 9 LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFG 66
L + V++ LL + H + PGP PLP LGN+L + +C FD + +++G
Sbjct: 13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILS---YHKGFCMFDMECHKKYG 69
Query: 67 DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGL 126
V+ PV+ + ++ LV + + RPF P G
Sbjct: 70 KVWGFYDGQQPVLAITDPDMIKTVLVKE----------------CYSVFTNRRPFGPVGF 113
Query: 127 LDKAVS 132
+ A+S
Sbjct: 114 MKSAIS 119
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 94.4 bits (233), Expect = 2e-19
Identities = 73/279 (26%), Positives = 120/279 (43%), Gaps = 10/279 (3%)
Query: 168 FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAE 227
FL +L A L+I KV+ +FLT+ + + E R+ + + D + +
Sbjct: 228 FLTPILEA----LNITVFPRKVI----SFLTKSVKQIKEGRLK-ETQKHRVDFLQLMIDS 278
Query: 228 MEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDV 287
+ +D L AG TTS+ L++ + + HPDVQ++VQ+EID V
Sbjct: 279 QNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTV 338
Query: 288 IGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITN 347
+ P + Y V++E R + + + + +D+E+ G IPKG ++
Sbjct: 339 LPNKAPPTYDTVLQLEYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIP 397
Query: 348 LSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFT 407
+ D W +P +F PE F + P + PF +G R C+G A + + L
Sbjct: 398 SYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALV 457
Query: 408 SLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 446
+LQ+FSF P L+T P L A R
Sbjct: 458 RVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
Score = 29.6 bits (65), Expect = 5.8
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 19/99 (19%)
Query: 35 PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93
PGP PLP LGN L F+ + FD + +++ V+ + P++ + ++ LV
Sbjct: 39 PGPTPLPFLGNAL--SFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVK 96
Query: 94 HGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVS 132
+ + RPF P G + A+S
Sbjct: 97 E----------------CYSVFTNRRPFGPVGFMKNAIS 119
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 93.6 bits (231), Expect = 3e-19
Identities = 75/277 (27%), Positives = 119/277 (42%), Gaps = 28/277 (10%)
Query: 143 RFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH----IPALAGKVLRFQKAFLT 198
+F + DP FL ++ FL V A+ V L I L+ V R +K+ L
Sbjct: 212 KFGFLDPLFLSIILFP---------FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262
Query: 199 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVT 258
+ HR+ D + + + + +D L AG T
Sbjct: 263 DKQK----HRL---------DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309
Query: 259 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 318
TS+ L++ L + HPDVQ+++Q+EID V+ P M Y V++E R
Sbjct: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP- 368
Query: 319 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 378
V + + +D+E+ G IPKG+ ++ ++ D W +P F PE F + +
Sbjct: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSID 427
Query: 379 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 415
P + PF G R C+G A M + L +LQ+FSF
Sbjct: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464
Score = 30.4 bits (67), Expect = 3.4
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 35 PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV 92
PGP PLP LGN+L ++ + FD + +++G ++ PV+ + +R LV
Sbjct: 39 PGPTPLPLLGNVL--SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLV 95
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 93.2 bits (230), Expect = 4e-19
Identities = 62/192 (32%), Positives = 102/192 (53%), Gaps = 8/192 (4%)
Query: 248 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTA 307
V ++ AG+ TTS TL+W + L+ HP+VQ+ V +EI +G+ P D +P A
Sbjct: 174 VTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRA 233
Query: 308 VIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTL-ITNLSSVLKDEAVWEKPFRFHP 366
++ E R ++P G +T D+ + G+ IPKGT L + + ++ +DE + + F P
Sbjct: 234 LLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRAKEFRP 291
Query: 367 EHFLDAQGHFVKPEAF--LPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRP 424
E +L +G + + F +PF G R+C+G +A +E+ L LLQH F + T
Sbjct: 292 ERWL-RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQH--FEIKTSSQTN 348
Query: 425 SHHGVFAFLVTP 436
+ H L+TP
Sbjct: 349 AVHAKTHGLLTP 360
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.141 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,547,074
Number of Sequences: 37866
Number of extensions: 884545
Number of successful extensions: 2900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2693
Number of HSP's gapped (non-prelim): 118
length of query: 446
length of database: 18,247,518
effective HSP length: 105
effective length of query: 341
effective length of database: 14,271,588
effective search space: 4866611508
effective search space used: 4866611508
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.