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Search of human proteins with 68303572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
(337 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 686 0.0
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 671 0.0
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 634 0.0
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 476 e-134
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 476 e-134
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 474 e-134
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 474 e-134
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 332 2e-91
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 332 4e-91
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 332 4e-91
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 332 4e-91
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 332 4e-91
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 329 2e-90
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 172 5e-43
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 166 3e-41
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 116 2e-26
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 113 3e-25
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 113 3e-25
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 113 3e-25
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 113 3e-25
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 112 4e-25
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 95 1e-19
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens] 71 1e-12
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens] 71 1e-12
gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens] 70 2e-12
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 68 1e-11
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 65 7e-11
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 65 7e-11
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 65 7e-11
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 65 7e-11
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 686 bits (1769), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN 180
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN 180
Query: 181 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK 240
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
Sbjct: 181 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK 240
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
Sbjct: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
Query: 301 LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF 337
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
Sbjct: 301 LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF 337
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 671 bits (1730), Expect = 0.0
Identities = 337/365 (92%), Positives = 337/365 (92%), Gaps = 28/365 (7%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNK---------------------------- 152
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNK
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
Query: 153 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 212
LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM
Sbjct: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
Query: 213 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 272
YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP
Sbjct: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
Query: 273 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 332
DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS
Sbjct: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
Query: 333 NMKGF 337
NMKGF
Sbjct: 361 NMKGF 365
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 634 bits (1635), Expect = 0.0
Identities = 307/335 (91%), Positives = 318/335 (94%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
M ++SGSKAE +VGGKYKLVRKIGSGSFGD+YL I TNGEEVAVKLESQK +HPQLLYE
Sbjct: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLY ILQGGVGIPH+ WYGQEKD NVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN 180
ISRIEYVHTKNF+HRDIKPDNFLMG GRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDK+
Sbjct: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH 180
Query: 181 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK 240
L GT RYASINAHLGIEQSRRDDMESLGYV MYFNRTSLPWQGLKA TKKQKYEKISEKK
Sbjct: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEE PDYMYLRQLFRILFRTLNHQYDYTFDWTM
Sbjct: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
Query: 301 LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMK 335
LKQKAAQQAASSSGQGQQAQT TGKQT+K K+N+K
Sbjct: 301 LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVK 335
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 476 bits (1224), Expect = e-134
Identities = 225/298 (75%), Positives = 258/298 (86%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG KY+L RKIGSGSFGDIYL NI +GEEVA+KLE K +HPQL ESK YK++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP I+W G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLAKKYRD RT QHIPYRE+KNLTGTARYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYVLMYFN SLPWQGLKAATK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQ 307
KG+P+EF+ YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK AA+
Sbjct: 242 KGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 476 bits (1224), Expect = e-134
Identities = 225/298 (75%), Positives = 258/298 (86%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG KY+L RKIGSGSFGDIYL NI +GEEVA+KLE K +HPQL ESK YK++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP I+W G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLAKKYRD RT QHIPYRE+KNLTGTARYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYVLMYFN SLPWQGLKAATK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQ 307
KG+P+EF+ YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK AA+
Sbjct: 242 KGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 474 bits (1220), Expect = e-134
Identities = 225/300 (75%), Positives = 259/300 (86%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG +Y+L RKIGSGSFGDIYL +I GEEVA+KLE K +HPQL ESK+YK++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP IRW G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLAKKYRD RT QHIPYRE+KNLTGTARYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYVLMYFN SLPWQGLKAATK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQA 309
KG+P+EFA YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK A++ A
Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 474 bits (1220), Expect = e-134
Identities = 225/300 (75%), Positives = 259/300 (86%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG +Y+L RKIGSGSFGDIYL +I GEEVA+KLE K +HPQL ESK+YK++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP IRW G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLAKKYRD RT QHIPYRE+KNLTGTARYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYVLMYFN SLPWQGLKAATK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQA 309
KG+P+EFA YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK A++ A
Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 332 bits (852), Expect = 2e-91
Identities = 166/302 (54%), Positives = 216/302 (71%), Gaps = 7/302 (2%)
Query: 2 ASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYES 61
+ SS S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E
Sbjct: 29 SGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEY 88
Query: 62 KLYKIL-QGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
+ YK L G G+P + ++G YN +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+
Sbjct: 89 RFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQL 148
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYR 176
+SR+EYVH+KN I+RD+KP+NFL IGR NK + +IDFGLAK+Y D T++HIPYR
Sbjct: 149 LSRMEYVHSKNLIYRDVKPENFL--IGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206
Query: 177 EDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKI 236
E K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI
Sbjct: 207 EHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 266
Query: 237 SEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTF 296
+ K +TP+E LC+ FP E A YL Y R L F E PDY YLR LF LF + +DY +
Sbjct: 267 GDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAY 326
Query: 297 DW 298
DW
Sbjct: 327 DW 328
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 332 bits (850), Expect = 4e-91
Identities = 167/300 (55%), Positives = 217/300 (72%), Gaps = 7/300 (2%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYRED 178
R+EYVH+KN I+RD+KP+NFL IGR NK + +IDFGLAK+Y D T++HIPYRE
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREH 206
Query: 179 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 238
K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI +
Sbjct: 207 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 266
Query: 239 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW
Sbjct: 267 TKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 332 bits (850), Expect = 4e-91
Identities = 167/300 (55%), Positives = 217/300 (72%), Gaps = 7/300 (2%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYRED 178
R+EYVH+KN I+RD+KP+NFL IGR NK + +IDFGLAK+Y D T++HIPYRE
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREH 206
Query: 179 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 238
K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI +
Sbjct: 207 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 266
Query: 239 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW
Sbjct: 267 TKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 332 bits (850), Expect = 4e-91
Identities = 167/300 (55%), Positives = 217/300 (72%), Gaps = 7/300 (2%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYRED 178
R+EYVH+KN I+RD+KP+NFL IGR NK + +IDFGLAK+Y D T++HIPYRE
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREH 206
Query: 179 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 238
K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI +
Sbjct: 207 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 266
Query: 239 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW
Sbjct: 267 TKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 332 bits (850), Expect = 4e-91
Identities = 167/300 (55%), Positives = 217/300 (72%), Gaps = 7/300 (2%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYRED 178
R+EYVH+KN I+RD+KP+NFL IGR NK + +IDFGLAK+Y D T++HIPYRE
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREH 206
Query: 179 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 238
K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI +
Sbjct: 207 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 266
Query: 239 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K +TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW
Sbjct: 267 TKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 329 bits (843), Expect = 2e-90
Identities = 162/298 (54%), Positives = 214/298 (71%), Gaps = 2/298 (0%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
SS S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 32 SSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYR 91
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G+P + ++G YN +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+I+
Sbjct: 92 FYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLIT 151
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIG--RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN 180
R+EYVHTK+ I+RD+KP+NFL+G + + + +IDFGLAK+Y D T++HIPYRE K+
Sbjct: 152 RMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKS 211
Query: 181 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK 240
LTGTARY SIN HLG EQSRRDD+E+LG++ MYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 212 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 271
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
+TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF +DY +DW
Sbjct: 272 RATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDW 329
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 172 bits (435), Expect = 5e-43
Identities = 113/328 (34%), Positives = 169/328 (51%), Gaps = 25/328 (7%)
Query: 9 AEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQ 68
A ++V ++K+++KIG G FG+IY A+++ E VA+K+ES + L E + K LQ
Sbjct: 26 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ 85
Query: 69 GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYV 127
G + G+ + +N +VM L G +L DL R FT+ T L L Q++ IE +
Sbjct: 86 GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 145
Query: 128 HTKNFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTAR 186
H+ F+HRDIKP NF MG + K +++DFGLA++Y N T P R GT R
Sbjct: 146 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY-TNTTGDVRPPRNVAGFRGTVR 204
Query: 187 YASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATK----KQKYEKISEKKMS 242
YAS+NAH E R DD+ SL Y+L+ F LPW+ +K + K+KYE
Sbjct: 205 YASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEH------- 257
Query: 243 TPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLK 302
+L K P+EF ++L++ L + PDY + +F + + FDW
Sbjct: 258 ---RMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDW---- 310
Query: 303 QKAAQQAASSSGQGQQAQTPTGKQTDKT 330
+KA A S+ TP + T +T
Sbjct: 311 EKAGTDALLST----STSTPPQQNTRQT 334
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 166 bits (420), Expect = 3e-41
Identities = 105/289 (36%), Positives = 152/289 (52%), Gaps = 9/289 (3%)
Query: 12 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71
+V ++K++RKIG G FG+IY A+++ E VA+K+ES + L E + K LQG
Sbjct: 16 LVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD 75
Query: 72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHTK 130
+ G+ +N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 76 HVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSV 135
Query: 131 NFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
F+HRDIKP NF MG C K +++DFGLA+++ N P R GT RYAS
Sbjct: 136 GFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQF-TNSCGDVRPPRAVAGFRGTVRYAS 194
Query: 190 INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 249
INAH E R DD+ SL Y+L+ F LPW+ +K E++ K ++
Sbjct: 195 INAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLML 248
Query: 250 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K P EF+++L++ L + PDY L +F +T FDW
Sbjct: 249 KHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 116 bits (291), Expect = 2e-26
Identities = 89/315 (28%), Positives = 154/315 (48%), Gaps = 33/315 (10%)
Query: 16 KYKLVRKIGSGSFGDIYLAINITNGEEVA------VKLES-------------QKARHPQ 56
++K+ IG G FG IYLA ++ + E V VK+E Q+A P+
Sbjct: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94
Query: 57 LLYESKLYKILQGGVGIPHIRWYGQE----KDYNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+ + + L+ +G+P G K Y ++MD G L+ ++ ++RF+ KT
Sbjct: 95 QIQKWIRTRKLKY-LGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153
Query: 113 VLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L+ +++ +EY+H ++H DIK N L+ ++ ++++L+D+GLA +Y H
Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGV--H 210
Query: 173 IPYREDKNL--TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKK 230
Y+ED GT + SI+AH G+ SRR D+E LGY ++ + LPW+ K
Sbjct: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270
Query: 231 QKYEKISEKKMSTPVEVLC---KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRT 287
+ KI ++ + C K P E A Y+ + L + E P Y LR + +
Sbjct: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330
Query: 288 LNHQYDYTFDWTMLK 302
+ + D D ++++
Sbjct: 331 IGSKDDGKLDLSVVE 345
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 113 bits (282), Expect = 3e-25
Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164
+ F TVL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
Query: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223
N + K GT + S++AH G+ SRR D+E LGY ++ + LPW Q
Sbjct: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
Query: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
LK A + K + E S E A +L L ++E P+Y L+++
Sbjct: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 113 bits (282), Expect = 3e-25
Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164
+ F TVL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
Query: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223
N + K GT + S++AH G+ SRR D+E LGY ++ + LPW Q
Sbjct: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
Query: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
LK A + K + E S E A +L L ++E P+Y L+++
Sbjct: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 113 bits (282), Expect = 3e-25
Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164
+ F TVL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
Query: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223
N + K GT + S++AH G+ SRR D+E LGY ++ + LPW Q
Sbjct: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
Query: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
LK A + K + E S E A +L L ++E P+Y L+++
Sbjct: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 113 bits (282), Expect = 3e-25
Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164
+ F TVL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
Query: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223
N + K GT + S++AH G+ SRR D+E LGY ++ + LPW Q
Sbjct: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
Query: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
LK A + K + E S E A +L L ++E P+Y L+++
Sbjct: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 112 bits (281), Expect = 4e-25
Identities = 88/291 (30%), Positives = 139/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESKLYKILQGG 70
G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K Y+ +
Sbjct: 3 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 60
Query: 71 --------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP G + + Y +VM+ LG L+ + + F T
Sbjct: 61 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 119
Query: 113 VLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 120 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 178
Query: 173 IPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATK 229
K GT + S++AH G+ SRR D+E LGY ++ + LPW Q LK A +
Sbjct: 179 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 238
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 239 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 289
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 94.7 bits (234), Expect = 1e-19
Identities = 60/196 (30%), Positives = 99/196 (50%), Gaps = 5/196 (2%)
Query: 88 LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIG 147
+VM+ LG L+ + + F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 1 MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
Query: 148 RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESL 207
++ ++++L D+GL+ +Y N + K GT + S++AH G+ SRR D+E L
Sbjct: 59 KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
Query: 208 GYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCR 264
GY ++ + LPW Q LK A + K + E S E A +L
Sbjct: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
Query: 265 GLRFEEAPDYMYLRQL 280
L ++E P+Y L+++
Sbjct: 179 SLAYDEKPNYQALKKI 194
>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
Length = 424
Score = 71.2 bits (173), Expect = 1e-12
Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 10/225 (4%)
Query: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
Query: 129 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTAR 186
++H ++ +N + +++ L +G A +Y + +H+ Y E G
Sbjct: 249 ENEYVHGNVTAENIFVD-PEDQSQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 305
Query: 187 YASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVE 246
+ S++ H G SRR D++SLGY ++ + LPW T+ +K P
Sbjct: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
Query: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTL 288
C + P+E YL L +EE P Y LR L + L
Sbjct: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 410
>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
Length = 474
Score = 71.2 bits (173), Expect = 1e-12
Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 10/225 (4%)
Query: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
Query: 129 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTAR 186
++H ++ +N + +++ L +G A +Y + +H+ Y E G
Sbjct: 299 ENEYVHGNVTAENIFVD-PEDQSQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 355
Query: 187 YASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVE 246
+ S++ H G SRR D++SLGY ++ + LPW T+ +K P
Sbjct: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
Query: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTL 288
C + P+E YL L +EE P Y LR L + L
Sbjct: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 460
>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
Length = 350
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 21/206 (10%)
Query: 17 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 76
Y+LVRK+G G + +++ AINITN E V VK+ + + ++ E K+ + L+GG I I
Sbjct: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI-LKPVKKKKIKREVKILENLRGGTNI--I 96
Query: 77 RWYGQEKDYNVLVMDLLGPSLEDL-FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHR 135
+ KD L+ + + F + T + +++ ++Y H+K +HR
Sbjct: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHR 156
Query: 136 DIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLG 195
D+KP N + I KL LID+GLA+ Y ++ N+ +RY L
Sbjct: 157 DVKPHNVM--IDHQQKKLRLIDWGLAEFYHP---------AQEYNVRVASRYFK-GPELL 204
Query: 196 IEQSRRD---DMESLGYVL--MYFNR 216
++ D DM SLG +L M F R
Sbjct: 205 VDYQMYDYSLDMWSLGCMLASMIFRR 230
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 67.8 bits (164), Expect = 1e-11
Identities = 60/236 (25%), Positives = 107/236 (45%), Gaps = 22/236 (9%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIP 74
G Y+L+R IG G+F + LA +I G EVA+K+ + +P L KL++ ++ G+
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL--QKLFREVRIMKGLN 114
Query: 75 H---IRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD--QMISRIEYVHT 129
H ++ + + L + + S ++F++ MK A Q++S + Y H
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 189
KN +HRD+K +N L+ + + + DFG + ++ G+ YA+
Sbjct: 175 KNIVHRDLKAENLLLDAEAN---IKIADFGFSNEFTLGSKLD--------TFCGSPPYAA 223
Query: 190 INAHLGIEQSRRD-DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTP 244
G + + D+ SLG +L SLP+ G K+ E++ K P
Sbjct: 224 PELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDG---HNLKELRERVLRGKYRVP 276
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 65.5 bits (158), Expect = 7e-11
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 26/249 (10%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 190
+HRD+K +N L+ + + + DFG + ++ G+ YA+
Sbjct: 173 RIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLD--------TFCGSPPYAAP 221
Query: 191 NAHLGIEQSRRD-DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK------MST 243
G + + D+ SLG +L SLP+ G K+ E++ K MST
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMST 278
Query: 244 PVEVLCKGF 252
E L K F
Sbjct: 279 DCENLLKRF 287
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 65.5 bits (158), Expect = 7e-11
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 26/249 (10%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 190
+HRD+K +N L+ + + + DFG + ++ G+ YA+
Sbjct: 173 RIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLD--------TFCGSPPYAAP 221
Query: 191 NAHLGIEQSRRD-DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK------MST 243
G + + D+ SLG +L SLP+ G K+ E++ K MST
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMST 278
Query: 244 PVEVLCKGF 252
E L K F
Sbjct: 279 DCENLLKRF 287
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 65.5 bits (158), Expect = 7e-11
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 26/249 (10%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 190
+HRD+K +N L+ + + + DFG + ++ G+ YA+
Sbjct: 173 RIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLD--------TFCGSPPYAAP 221
Query: 191 NAHLGIEQSRRD-DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK------MST 243
G + + D+ SLG +L SLP+ G K+ E++ K MST
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMST 278
Query: 244 PVEVLCKGF 252
E L K F
Sbjct: 279 DCENLLKRF 287
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 65.5 bits (158), Expect = 7e-11
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 26/249 (10%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 190
+HRD+K +N L+ + + + DFG + ++ G+ YA+
Sbjct: 173 RIVHRDLKAENLLLDADMN---IKIADFGFSNEFTVGGKLD--------TFCGSPPYAAP 221
Query: 191 NAHLGIEQSRRD-DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK------MST 243
G + + D+ SLG +L SLP+ G K+ E++ K MST
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMST 278
Query: 244 PVEVLCKGF 252
E L K F
Sbjct: 279 DCENLLKRF 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,681,864
Number of Sequences: 37866
Number of extensions: 487396
Number of successful extensions: 2348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 505
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 1269
Number of HSP's gapped (non-prelim): 805
length of query: 337
length of database: 18,247,518
effective HSP length: 103
effective length of query: 234
effective length of database: 14,347,320
effective search space: 3357272880
effective search space used: 3357272880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.