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Search of human proteins with 6715600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo
sapiens]
(2230 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 4242 0.0
gi|71061468 centromere protein E [Homo sapiens] 311 3e-84
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 295 3e-79
gi|55770834 centromere protein F [Homo sapiens] 284 6e-76
gi|148746195 trichohyalin [Homo sapiens] 274 6e-73
gi|21735548 centrosomal protein 2 [Homo sapiens] 272 3e-72
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 253 2e-66
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 244 5e-64
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 244 5e-64
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 241 6e-63
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 241 8e-63
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 238 4e-62
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 237 8e-62
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 232 3e-60
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 231 8e-60
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 230 1e-59
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 227 1e-58
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 224 1e-57
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 224 1e-57
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 215 4e-55
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 213 2e-54
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 213 2e-54
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 213 2e-54
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 213 2e-54
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 213 2e-54
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 213 2e-54
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 213 2e-54
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 213 2e-54
gi|148536869 ninein isoform 2 [Homo sapiens] 209 2e-53
gi|33946313 ninein isoform 4 [Homo sapiens] 209 3e-53
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 4242 bits (11001), Expect = 0.0
Identities = 2230/2230 (100%), Positives = 2230/2230 (100%)
Query: 1 MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS
Sbjct: 1 MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM
Sbjct: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
Query: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 181 SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM 240
SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM
Sbjct: 181 SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM 240
Query: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
Query: 301 TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ 360
TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ
Sbjct: 301 TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ 360
Query: 361 DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL
Sbjct: 361 DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480
STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK
Sbjct: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480
Query: 481 LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL
Sbjct: 481 LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Query: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
Query: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE
Sbjct: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
Query: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK 840
NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK
Sbjct: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK 840
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE
Sbjct: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK 960
QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK 960
Query: 961 QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR
Sbjct: 961 QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
Query: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI 1080
LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI
Sbjct: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI 1080
Query: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE 1140
LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE
Sbjct: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE 1140
Query: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE 1200
VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE
Sbjct: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE 1200
Query: 1201 DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV 1260
DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV
Sbjct: 1201 DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV 1260
Query: 1261 KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK
Sbjct: 1261 KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
Query: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
Query: 1381 VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN
Sbjct: 1381 VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
Query: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG 1500
KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG
Sbjct: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG 1500
Query: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE
Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK
Sbjct: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
Query: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
Query: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 1801 LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860
LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860
Query: 1861 SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN 1920
SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN 1920
Query: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIK 1980
MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIK
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIK 1980
Query: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQ 2040
QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQ
Sbjct: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGN 2100
LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGN
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGN 2100
Query: 2101 DNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGN 2160
DNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGN
Sbjct: 2101 DNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGN 2160
Query: 2161 LYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARL 2220
LYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARL
Sbjct: 2161 LYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARL 2220
Query: 2221 MFTSPRSGIF 2230
MFTSPRSGIF
Sbjct: 2221 MFTSPRSGIF 2230
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 311 bits (798), Expect = 3e-84
Identities = 473/2167 (21%), Positives = 962/2167 (44%), Gaps = 290/2167 (13%)
Query: 101 SLNRL-DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSE 159
S+N L ++D S S SD+ S D + + +L+ + +E L+S R Y
Sbjct: 454 SINLLREIDESVCS---ESDVFSNTLDTLSEIEWNPATKLLNQ-ENIESELNSLRADYDN 509
Query: 160 LVTAYQMLQREKKKLQGILSQSQD----KSLRRIAELREELQMDQQAK------KH---- 205
LV Y+ L+ EK++++ L + D ++L R + +E+Q+ + KH
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 206 ---LQEEFDASLE---EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259
L+ E + +E EK+ I LQ + Q+L N + +D+ L +E ++
Sbjct: 570 NQDLENELSSKVELLREKEDQIKKLQEYID--SQKLEN--IKMDLSYSLESIEDPKQMKQ 625
Query: 260 KEENPESDGEPVVEDGTSVKTLET-LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEA 318
+ E+ + +++ L++++K K+ + IQ ++ Q +
Sbjct: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 319 LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE 378
L+++L E+ K+ L + K + + + I L+++ + E + E +
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745
Query: 379 MKE-----EEIAQLRSRIKQ-------MTTQGEELREQ---KEKSERAAFEELEKALSTA 423
+ E E+ +LR I+ +T++ ++L + KE + EE+ K
Sbjct: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
Query: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
T+ + E + KT+ E++ + +E R+ QE+V++ K++ + + L
Sbjct: 806 ATTQSNYKSTDQEF-QNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD-SSLGA 863
Query: 484 LHEKELARKEQEL---TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
L + EL+ K QEL T+++Q R E EQ+K LE S + +EK +L E+L
Sbjct: 864 L-KTELSYKTQELQEKTREVQERLNEM-EQLKEQLENRDSTLQTVEREK----TLITEKL 917
Query: 541 E--LQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK 598
+ L++ LT+ ++ L+ LQ+ + R +L+S + ++ N + + L LE+ K
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERD---QLKSDIHDTVNMNIDTQEQLRNALESLK 974
Query: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL-- 656
+H + I + K E+ H ++ K + QQ ++K ++ + +TL
Sbjct: 975 -QHQETINTLKSKISEEVSRNLHMEENTGETKDEF--QQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 657 -LKDKEIIFQAH-----IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
+KD EII Q I+E NE + L+ E E L ++L E ++ + +EEL +L
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQ-QMLESVIAEKEQLKTDLKENIEMTIENQEELRLL 1090
Query: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS-----IQRTEKALKDQINQLE--- 762
D+ K +QE+ A ++KNH +I KE E+S + E+ LK++ QL+
Sbjct: 1091 GDELKK-QQEIVA---QEKNH------AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
Query: 763 ---LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
L ++E +++ +ENL+ ++K E L+ + + +E+ K+ +
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ 879
+ L++ ETER L + E+EA EL I +++ + +++ + +
Sbjct: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK-----KEIEILTQKLSAK 934
K + + LE + + ++ +L E++ ++ ++E + E+E+LT++ + K
Sbjct: 1261 KTAQIINTQD--LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK 1318
Query: 935 EDSIHILNEEYETKFKNQ--EKKMEKVKQKAKEMQ--ETLKKKLLDQEAKLKKELENTAL 990
DS + E E N+ ++ E++K KE +T+K+ L + +LK+ + T
Sbjct: 1319 -DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 991 EL--SQKEKQFNAKMLEMAQANSAGISD---------AVSRLETNQKEQIESLTEVHRRE 1039
++ SQ +++ + M E + +S+ A+ R+E + L E H
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
Query: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
K + ++ ++LQ + E+ E +Q +K+ + +EE+ LKE
Sbjct: 1438 ---------KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQD----ETKLKAHLEKL-EVDLNKSLKENTFLQ 1154
Q+ T+NEL+ L +K ++++ + KL+ ++++ E + ++K+ + +Q
Sbjct: 1489 ----QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
E++ ELK E K K S L S E L+ S E+ +++K E K++ E L
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEALQ 1603
Query: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
I+ D + T+ ++ AK E S K L + T V E K C + L
Sbjct: 1604 IERDQLKENTKEIV-AKMKE----SQEKEYQFL--------KMTAVNETQE-KMCEIEHL 1649
Query: 1275 EAQLRQLT---EEQNTLNISFQQATHQLEEKENQIKSMKADI----ESLVTEKEALQKEG 1327
+ Q E T NI Q H+ E+ + + D+ E+L E++ L++
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
Query: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT---------D 1378
EK+ + + L E+ + ++ + EK EIS++ K L D
Sbjct: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 1379 LNVQLQNSIS-----------------LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV 1421
L +Q + I+ +SEK +S+++K + +L +++Q+L
Sbjct: 1770 LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANE 1829
Query: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
L I+ + V++ K SE ++ + + T+ +L+I+ +++ +E E++
Sbjct: 1830 HQL----ITLKKDVNETQKKVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKM-EKKESNLETELKSQTARIM---------ELE 1531
+ +E D + + LK E + K + E K +LE + + +TAR++ +L
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
+ I++KTI+I +++ K+ ++ KD EL +K+Q Q+ K+ ++ +E +
Sbjct: 1945 EKISEKTIQI---SDIQKDLDKSKD----ELQKKIQELQK----KELQLLRVKEDV---- 1989
Query: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAI 1651
N + E+E KK+ E NLS++S + L +L L E++ A+++
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES----LEEIRIVAKER---- 2041
Query: 1652 KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ---SETLIV 1708
++ +E K + ++ L + R+R+ H ++ + + + Q +E+L
Sbjct: 2042 -----DELRRIKESLKMERDQFIATLREMIA-RDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
Query: 1709 PRSAKNVAAYTEQEEADSQGCVQKTYE--EKISVLQRNLTEKEKL------LQRVGQEKE 1760
S E D C+ + EK Q+ L+ + K LQ EK
Sbjct: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKL 2155
Query: 1761 ETVSSHFEMRCQYQERLIKLEHA-----EAKQHEDQSMIGHLQEELEEKNKKYSLIVA-Q 1814
T + M ++ + KL++ + K+ + +S+ + ++E K+ L++ Q
Sbjct: 2156 FTANQRCSM--EFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQ 2213
Query: 1815 HVEKEGGK-----NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK-ELDSCLVRQKE 1868
H++++ +++ QN++ +++ K E E IK E L +KE
Sbjct: 2214 HLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP------SIKTEFQQVLSNRKE 2267
Query: 1869 VHRVEMEELTSKY--EKLQ-ALQQMDGR---------NKPTELLEENTEEKSKSHLVQPK 1916
+ + E L +++ EKL+ +Q+ + R N+ ++ E+TE + +S + +
Sbjct: 2268 MTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
Query: 1917 LLSNMEA--QHNDLEFKLAGAEREKQKLGKEIVRLQKDLR---------MLRKEHQQELE 1965
++++ + N+ FK + G ++ +D + L E +ELE
Sbjct: 2328 WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELE 2387
Query: 1966 IL---KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE +E KI + Q++LE+ ++ ++ + ++ + + LE T KETI
Sbjct: 2388 NSLHEAKESAMHKESKIIKMQKELEVTND-----IIAKLQAKVHESNKCLEKT-KETIQV 2441
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Q+ A + ++EE L K+ + D + + AK +E+ + A + + + ++ E
Sbjct: 2442 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
Query: 2083 ELQKKYQ 2089
L++ Q
Sbjct: 2502 NLRRSQQ 2508
Score = 271 bits (693), Expect = 5e-72
Identities = 443/2107 (21%), Positives = 887/2107 (42%), Gaps = 347/2107 (16%)
Query: 288 VKRQENLLKRCKETIQS-----------------HKEQCTLLTSEKEALQEQLDERLQEL 330
V E LLKR ++ I K+Q L EK+ LQ+ +E+++ L
Sbjct: 338 VSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397
Query: 331 -------------------------------EKIKDLHMAEKTKLITQL-----RDAKNL 354
K+K+ + A++ + T + + + NL
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
Query: 355 IEQLEQ---DKGMVIAETKRQMHE----------TLEMKEEEIAQLRSRIKQMTTQGEEL 401
+ ++++ + V + T + E E E E+ LR+ + E+L
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
Query: 402 REQKEKSERAAFE--ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
R +KE+ E E +L++ + +KT++ + +K + K +E L+ EL
Sbjct: 518 RTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL 577
Query: 460 SRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518
S K E++ + E+QI KLQ+ + ++L + +L+ L++ E +QMK L +
Sbjct: 578 SS-KVELL----REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED--PKQMKQTLFDA 630
Query: 519 QSEYLKISQEKE--QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576
++ L +E + E+L L+E + + EN ++ Q + E + ++LE L
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 577 EKSLQE--------NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
+ + E + KDL +LE E K + E +K E+ +++ +
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELE----GKITDLQKELNKEVEENEALREEVILL 746
Query: 629 EKLQVLKQQYQTEMEKLREKCEQ------EKETLLKD---KEIIFQAHIEEMNEKTLEKL 679
+L+ L + + +++++K E+ EK+ L + KE Q +EE+ KT + L
Sbjct: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG-KTKDDL 805
Query: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Q+ +S E E++ ++ ++ ++M QE+ E Q+ DS
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE-----AQKFDSS 860
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
+ ALK +++ L+E+ + ++E +E L+ ++ + LQ +
Sbjct: 861 L-----------GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV-------AEVEAQKKDV 852
+ T E+ K ++ L+Q L+ ER L + + + Q ++
Sbjct: 910 KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA 969
Query: 853 CTELDAHKIQVQDLMQQLEKQ---NSEMEQKVKSLTQVYESKLEDGNKEQE------QTK 903
L H+ + L ++ ++ N ME+ ++ K+ +K+Q+ QT
Sbjct: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
Query: 904 QILVEKENMILQMRE-----GQKKEIEILTQKLSAKEDSIHI-LNEEYETKFKNQE---- 953
V+ +I Q R+ +K E++ + + + A+++ + L E E +NQE
Sbjct: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 954 -----KKMEKVKQKAKEMQETLKK-----KLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
KK +++ A+E +KK + D+ A+++++L+ + +L +K++Q
Sbjct: 1090 LGDELKKQQEI--VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
Query: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
EM++ + E KE E R EL +KLN+ EE++ I
Sbjct: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL-------AQKLNENYEEVKSI-- 1198
Query: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV--------------KQDTTLN 1109
KE++V + QK F E++ + I ++ G+ + T++
Sbjct: 1199 ----TKERKVLKELQK--SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 1110 ELQEQLKQKSAHV---NSLAQDETKLKAHLEKL--EVDLNKSLKENTFLQEQLVELKMLA 1164
EL+ + +K+A + L + TKL+ + L E +L ++KE + QE + EL++L
Sbjct: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312
Query: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
E+ K S ++++ ++ KSL + K + E L + K
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV-------KH 1365
Query: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
+ L E L I S++ Q ++ +KE T VSE+E Q +
Sbjct: 1366 DQLKEHIRETLAKIQESQSK---------QEQSLNMKEKDNETTKIVSEME-QFKPKDSA 1415
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
+ I + +L+E +++KS+ + + L +E LQ E + Q + KE L
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE--SDQLKENIKEIVAKHL 1473
Query: 1345 KKE---------LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-------- 1387
+ E L E + ++ L EK+ EIS++ KQL +N +LQN I
Sbjct: 1474 ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533
Query: 1388 -----SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
+SE + ++ L KQ+ E + +Q + K+ L+ + E++ K
Sbjct: 1534 QFNIKQISEVQEKVNEL-KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI-KE 1591
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK--RFDCLKG 1500
E K+ Q ++ +KE ++ K KE+ EK+ Q + + Q K + LK
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
Query: 1501 EMEDDKSKMEKKESNLETELKSQTARIME-LED--HITQKTIEIESLNEVLKNYNQQKDI 1557
+ E K +E N+ETE T + E LE+ +T++ ++ S+ E LK Q
Sbjct: 1652 QFETQKLNLE----NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Query: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
+E + + QE + +KE +E I L V E+ +K+LEH N ++K+
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
Query: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
++ L+ + ++A + K +Q+ + ++S+ +K +K E+ ++L
Sbjct: 1768 QD---------LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 1678 NTKLQEREREVHILEEKLKSVESSQ---SETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734
K+QE + H L K V +Q SE + + K+ + + E ++ QK +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 1735 ---EEKISVLQR--NLTEKEKLLQ----RVGQEKEETVSSHFEMRCQYQ-ERLIKLEHAE 1784
EE SV++ NL E+ L+ ++ + +ET + E++ + + R++ EH E
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Query: 1785 A------KQHEDQSMIGHLQEEL----EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
K E I +Q++L +E KK + + ++ K ++ N
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE 1998
Query: 1835 FDDVQKTLQEKELTCQI-----------LEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
+ ++K + + L+ Q L + ++E+ + E+ R++ + +
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058
Query: 1884 LQALQQMDGRNKPT-------ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
+ L++M R++ LL + + ++S + + + ++++++
Sbjct: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN 2118
Query: 1937 REKQKLGKEIVRLQKDLRM----------LRKEHQQEL------------EILKK-EYDQ 1973
R L KEI QK+L M L+ +H ++L I+KK +Y
Sbjct: 2119 RLSLDLEKEI-EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
Query: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL--- 2030
KIK+EQ + ++ + +F ++ +K++EL + I+ EL
Sbjct: 2178 SYVTKIKEEQHE-------SINKFEMDFIDEV-EKQKELLIKIQHLQQDCDVPSRELRDL 2229
Query: 2031 -----LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ--LEE 2083
++ H EE +LK +E + +T ++++L R+E L T+ +E+
Sbjct: 2230 KLNQNMDLHIEE---ILKDFSESEFPSIKT--EFQQVLSNRKEMTQFLEEWLNTRFDIEK 2284
Query: 2084 LQ---KKYQQKLEQEENPGNDN-VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
L+ +K ++ Q N N+ + IM T+ +++ IS +E+ + + +L+++
Sbjct: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS------KEWEQDLKSLKEK 2338
Query: 2140 LKKYEKN 2146
+K KN
Sbjct: 2339 NEKLFKN 2345
Score = 232 bits (591), Expect = 4e-60
Identities = 381/1923 (19%), Positives = 850/1923 (44%), Gaps = 232/1923 (12%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
K+L +++ E + ++ + ++ S S R+R +E+L T ++
Sbjct: 727 KELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD-------- 778
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDP-PSDMD 121
KL V ES + ++E +K+ L T S N D +F D +
Sbjct: 779 -KLFSEVVHKESRVQGLLEEI---GKTKDDLATTQS----NYKSTDQEFQNFKTLHMDFE 830
Query: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
+ + ++ ++ +N+E ++ + ++ SS +EL Q LQ + +++Q L++
Sbjct: 831 QKYKMVLEENERMNQE-IVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889
Query: 182 QDKSLRRIAELREE-LQMDQQAKKHLQEEFDASLEE-------KDQYISVLQTQVSLLKQ 233
+ L+ E R+ LQ ++ K + E+ +LEE KD + LQ + + +
Sbjct: 890 EQ--LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD-LKQLQESLQIERD 946
Query: 234 RLRNG-----PMNVDV-------LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL 281
+L++ MN+D L+ L Q + + + E +E+ T +T
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG-ETK 1005
Query: 282 ETLQQR---VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM 338
+ QQ+ + ++++L + +T+ + + ++ +++ L + EL+++ + +
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS--LIQEKNELQQMLESVI 1063
Query: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE------MKEEEIAQLRSRIK 392
AEK +L T L++ + + +++ ++ E K+Q + KE E+++ R+
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA 1123
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ + +E +Q ++ ++ +++ +S QK LK E+ + T+E E ER
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQLLN-VQEEMSEMQKKINEIENLKNELKNKELTLEHM-ETER 1181
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
+ L Q+L+ +EV + K+ + + +LQK E E + ++++ + +E++K
Sbjct: 1182 LELAQKLNENYEEVKSITKE--RKVLKELQKSFETERDHLRGYI-REIEATGLQTKEELK 1238
Query: 513 VA---LEKSQSEYLKISQEKEQQESLALEELELQKK--------AILTESENKLRDLQQE 561
+A L++ Q ++ + ++ + + +L+K +L E + L ++++
Sbjct: 1239 IAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEV 1298
Query: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
+ET T + LE +++ + +E E+ + N++ ++ + E++SL
Sbjct: 1299 SETQETM-----NELELLTEQSTTKDSTTLARIEMERLRLNEKF----QESQEEIKSLTK 1349
Query: 622 QQDALWT--EKLQV----LKQQYQTEMEKLREKCEQEKETL-LKDKEIIFQAHIEEMNEK 674
++D L T E L+V LK+ + + K++E +++++L +K+K+ + EM +
Sbjct: 1350 ERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734
+ + + E+E L LS+ L+ H + ++ KD ++++ L+++ D+ K + ++
Sbjct: 1410 KPKDSALLRIEIEMLG--LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 735 QVDSIIKEHEVSIQRTEKALKDQ---INQLELLLKERDKHLKEHQAHVENLEADIK---- 787
V + E E ++ LK+Q IN+L + L E++ + Q +E + ++
Sbjct: 1468 IVAKHL-ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 788 -----------RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
+ E+Q+ +L F+ ++ A ++ E ++ +L +L + + E
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE--- 893
++ K+ E++ ++ + E D K ++++ ++ K++ E E + +T V E++ +
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM-KESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 894 -DGNKEQEQTKQIL---VEKENMIL---------QMREGQKK--EIEILTQKLSAKEDSI 938
+ KEQ +T+++ +E EN+ L +MR K+ ++ + + L + D +
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL 1705
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
E T+ ++++++ V KE QET+ K L ++ E+ N +L
Sbjct: 1706 KENLRETITRDLEKQEELKIVHMHLKEHQETIDK-LRGIVSEKTNEISNMQKDLEHSNDA 1764
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--RELNDVISIWEKKLNQQAE 1056
A+ L+ I + + + KEQ E++ ++ E D +S +K L
Sbjct: 1765 LKAQDLK--------IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816
Query: 1057 ELQE------IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI-------TWLKEEGVK 1103
+LQE +E QL +++V E ++K+ E E++ K+I + L+ E +
Sbjct: 1817 KLQEKIQELKANEHQLITLKKDVNETQKKV----SEMEQLKKQIKDQSLTLSKLEIENLN 1872
Query: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163
L+E E++K ++L + E LK ++L+ L ++ + +Q++L +ML
Sbjct: 1873 LAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARML 1932
Query: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL---AIQLDIC 1220
++E K V +L K+ + ++ +KS L+ K E +K +L +++
Sbjct: 1933 SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS 1992
Query: 1221 CKKTEALLEAKTN-ELINISSSKTNAILSRISHCQHRT--------------TKVKEALL 1265
KK + + K E N+S +++ H + ++KE+L
Sbjct: 1993 HKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
Query: 1266 IK----TCTVSEL---EAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT 1318
++ T+ E+ + Q Q+ E+ L+ Q T L EK ++IK + +
Sbjct: 2053 MERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112
Query: 1319 EKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD 1378
E L N+ EKE + +KELS + A L L+ K +E + Q
Sbjct: 2113 HYECL-----NRLSLDLEKE---IEFQKELSMRVKA-NLSLPYLQTKHIEKLFTANQRCS 2163
Query: 1379 LNV-----QLQNSISL-----SEKEAAISSLRKQYDEE---KCELLDQVQDLSFKVDTLS 1425
+ +L+ +S E+ +I+ + +E + ELL ++Q L D S
Sbjct: 2164 MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPS 2223
Query: 1426 KE-KISALEQ-----VDDWSNKFSEWK-KKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
+E + L Q +++ FSE + ++ F Q + KE+ LE ++ +
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283
Query: 1479 EQINLLKEELD---QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHI- 1534
+ N +++E D Q N F+ + ++ ++ E++ + + E + + E + +
Sbjct: 2284 KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343
Query: 1535 -TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593
+T++ + N Q + + Q E E +N + EA+E + E++
Sbjct: 2344 KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESK 2403
Query: 1594 VYSMKAELETK-------KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
+ M+ ELE + ++ N ++ +E ++ L+D K+A + ++
Sbjct: 2404 IIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD--------KVALGAKPYKE 2455
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
+I +K +L+ EK + K+ E +S ++ ++ + +L E L+ + +Q +T
Sbjct: 2456 EIEDLKMKLVKIDLEKMKNAKE-FEKEISATKATVEYQKEVIRLLRENLRRSQQAQ-DTS 2513
Query: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766
++ + G VQ T K +L+ EK + ++ Q+ E+ +
Sbjct: 2514 VISEHTDPQPSNKPLTCGGGSGIVQNT---KALILKSEHIRLEKEISKLKQQNEQLIKQK 2570
Query: 1767 FEM 1769
E+
Sbjct: 2571 NEL 2573
Score = 176 bits (446), Expect = 2e-43
Identities = 273/1261 (21%), Positives = 544/1261 (43%), Gaps = 203/1261 (16%)
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
N+ E+L + +R+E+ D L +Q EE+ Q EK+Q L++K LL
Sbjct: 336 NEVSTDEALLKRYRKEIMD--------LKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQ 387
Query: 1084 GCEKEEM---------NKEITWLKEEGVKQDTTLNELQEQL-KQKSAHVNSLAQDETKLK 1133
+ E++ + +T +E K+ + ++ K K+++ T +
Sbjct: 388 KVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNIT 447
Query: 1134 AHLEKLEVDLNKSLKENTFLQEQLVE--LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
KL ++L + + E+ + + L L+E + ++L ++ + + E SL++
Sbjct: 448 TKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ-ENIESELNSLRAD 506
Query: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN-----ELINISSSKTNAI 1246
++ N L+ + L +K EL ++ + EAL E KT +LI+ S+ N +
Sbjct: 507 YD--NLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL-ERKTKKDQEMQLIHEISNLKNLV 563
Query: 1247 LSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE---EQNTLNIS------------ 1291
H + ++ L K + E E Q+++L E Q NI
Sbjct: 564 ----KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED 619
Query: 1292 --------FQQATHQLEEKE------NQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
F T L+ K ++ +K ++ L T + ++ + Q K
Sbjct: 620 PKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
Query: 1338 ESCITQLKKELSENINAVT----LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE-- 1391
+ L+KEL N +T L+ ++ + + L ++TDL +L + +E
Sbjct: 680 KKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEAL 739
Query: 1392 -KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV--------------- 1435
+E + S K E L ++QD S ++ ++ EK +V
Sbjct: 740 REEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG 799
Query: 1436 ---DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
DD + S +K Q + QN K L + E K K E++E++N L ++
Sbjct: 800 KTKDDLATTQSNYKSTDQ----EFQN-FKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 1493 KRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN 1552
++FD G ++ + S + EL+ +T + E + + Q ++E+ + L+
Sbjct: 855 QKFDSSLGALKTELSYKTQ-------ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS-----MKAELETKKKE 1607
++K + ++L Q L+ + L +EKD+ +K+ +E + +Q+ S + ++T++ +
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDD-LKQLQESLQIERDQLKSDIHDTVNMNIDTQE-Q 965
Query: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKL------AELKRKAEQKIAAIKKQLLSQMEE 1661
L + S+K +E + L+ ++ E + L E K + +QK+ I K+ + +
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 1662 KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQ 1721
+ ++ + E K+ +E + L++ L+SV ++ E L Q
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV-IAEKEQLKTDLKENIEMTIENQ 1084
Query: 1722 EEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLE 1781
EE G K +E ++ + + +KE L R E E Q QE+ +L
Sbjct: 1085 EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLL 1144
Query: 1782 HAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
+ + + E Q I ++ E KNK+ +L +H+E E ++ Q L +++V+
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTL---EHMETE----RLELAQKLNENYEEVKS 1197
Query: 1841 TLQEKELTCQI----------LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
+E+++ ++ L I+E+++ ++ KE ++ L E + L++
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257
Query: 1891 DGRNKPTELLEENTEEKSKSHLV----------QPKLLSNM----EAQHNDLEFKLAGAE 1936
K +++ NT++ KSH + +LL N+ E Q E +L E
Sbjct: 1258 VSE-KTAQII--NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL-TE 1313
Query: 1937 REKQKLGKEIVRLQKD-LRMLRK--EHQQELEILKKEYDQEREEKIKQEQEDLELKHNST 1993
+ K + R++ + LR+ K E Q+E++ L KE D +K +E LE+KH+
Sbjct: 1314 QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDN-----LKTIKEALEVKHDQ- 1367
Query: 1994 LKQLMREF--NTQLAQKEQELEMTIKETINKAQEVEAEL-------------------LE 2032
LK+ +RE Q +Q +QE + +KE N+ ++ +E+ L
Sbjct: 1368 LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427
Query: 2033 SHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD-----LQTQLEELQKK 2087
+E++ +K +A++ DDL +R +E+L + +++ +++ L+T+ EEL+
Sbjct: 1428 KRLQESHDEMKSVAKEKDDL----QRLQEVLQSESDQLKENIKEIVAKHLETE-EELKVA 1482
Query: 2088 YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
+ EQEE TI EL+ L++K T IS ++Q+ + D+L+ + +
Sbjct: 1483 HCCLKEQEE-------TINELRVNLSEKETEIS-------TIQKQLEAINDKLQNKIQEI 1528
Query: 2148 Y 2148
Y
Sbjct: 1529 Y 1529
Score = 173 bits (438), Expect = 2e-42
Identities = 323/1544 (20%), Positives = 662/1544 (42%), Gaps = 208/1544 (13%)
Query: 7 QKISEEQQQLQQALAPAQASSNSSTPTR--MRSRTSSFTEQLDEGTPNRESGDTQSFAQK 64
+ + E+ +L Q L S T R ++ SF + D + K
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 65 LQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEA 124
+L++ + + L RS S+++ + +N DL+ S + E
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTA------QIINTQDLEKSHTKLQEEIPVLHEE 1288
Query: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
++L+ N +++ Q + + +E K S T ++ E+ +L +SQ++
Sbjct: 1289 QELLPNVKEVSETQ--ETMNELELLTEQSTTKDS---TTLARIEMERLRLNEKFQESQEE 1343
Query: 185 SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV 244
I L +E + K+ L+ + D E + ++ +Q S +Q L + +
Sbjct: 1344 ----IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNET 1399
Query: 245 LKPLPQLE---PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQR--VKRQENLLKRCK 299
K + ++E P+ + E + G S + E+ + V ++++ L+R +
Sbjct: 1400 TKIVSEMEQFKPKDSALLRIE--------IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451
Query: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLH--MAEKTKLITQLRDAKNLIEQ 357
E +QS +Q KE ++E + + L+ E++K H + E+ + I +LR NL E+
Sbjct: 1452 EVLQSESDQL------KENIKEIVAKHLETEEELKVAHCCLKEQEETINELR--VNLSEK 1503
Query: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR--IKQMTTQGEELREQKEKSERAAFEE 415
+ + I + +++ L+ K +EI + + IKQ++ E++ E K+ F+E
Sbjct: 1504 --ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ------FKE 1555
Query: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ--ELSRVKQEVV---DVM 470
KA + A + ++++M E ++++ EE +I +++ E+ RV++ + D +
Sbjct: 1556 HRKA------KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQL 1609
Query: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM-KVALEKSQSEYLKISQEK 529
K++++E +AK+ KE KE + K T E QE+M ++ K Q E K++ E
Sbjct: 1610 KENTKEIVAKM-----KESQEKEYQFLK--MTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 530 EQQESLALEEL---ELQKKAILTESENKLRDLQQEAETYRTRILE-LESSLEKSLQENKN 585
+ E++ L ++ L++ +T+ + LR +++ + R ++ E L ++ + L E +
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL-EKQE 1721
Query: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHK---TELESLKHQQDALWTEKLQVLKQQYQTEM 642
+ K + +HL+ + +K ++ EK + L+H DAL K Q LK Q + +
Sbjct: 1722 ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL---KAQDLKIQEELRI 1778
Query: 643 EKLREKCEQEKETLLK-------DKEIIFQAHIEEMNEKTLEK---LDVKQTELESLSSE 692
+ K +QE L+ DK Q +E N K EK L + +L +L +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD 1838
Query: 693 LSEVLKARHKLEEELSVLKDQTDKM-KQELEAKMDEQKNHHQ-QQVDSIIKEHEVSIQRT 750
++E K ++E+ +KDQ+ + K E+E QK H +++ S++KE + +++R
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-NLRRV 1897
Query: 751 EKALKDQINQLELLLKE---RDKHL-----------KEHQAHVENLEADIKRSEGELQQA 796
E+ LK + +QL+ L+E RD + KEH+ V+ L I ++
Sbjct: 1898 EETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI 1957
Query: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
LD +S Q K E Q +LQ LL ++ + + K++ E+E KK
Sbjct: 1958 QKDLD-----KSKDELQKKIQELQKKELQ--LLRVKEDVNMSHKKINEMEQLKK------ 2004
Query: 857 DAHKIQVQDL-MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
+ + Q+L MQ + N ++ +K+ + ++ ++ + + + +E++ I
Sbjct: 2005 ---QFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIAT 2061
Query: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK-KL 974
+RE + A++ H + E Q+ E +++K ++E LK+
Sbjct: 2062 LRE------------MIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE 2109
Query: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT- 1033
+D + L +L+L +KE +F ++ +AN + + L+T E++ +
Sbjct: 2110 MDDHYEC---LNRLSLDL-EKEIEFQKELSMRVKANLS-----LPYLQTKHIEKLFTANQ 2160
Query: 1034 ----EVHR--RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
E HR ++L V+S K +Q E + + + E E++ EL KI +
Sbjct: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQ-KELLIKIQHLQQDC 2219
Query: 1088 EEMNKEITWLKE--------EGVKQDTTLNELQ------EQLKQKSAHVNSLAQDETKLK 1133
+ ++E+ LK E + +D + +E +Q+ + ++ +
Sbjct: 2220 DVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR 2279
Query: 1134 AHLEKLEVDLNKS----LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
+EKL+ + K + N F +++ + + E + + + ++ K +++ +SLK
Sbjct: 2280 FDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS---KEWEQDLKSLK 2336
Query: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249
+EK K+ ++ L LA + + N+ +++S T +
Sbjct: 2337 EKNEKLFKN-------YQTLKTSLA-------SGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 1250 ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI--- 1306
I ++ + KE+ + K + +++ +L + L ++ LE+ + I
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL 2442
Query: 1307 --------KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
K K +IE L K L K + + A E E I+ K + + L+
Sbjct: 2443 QDKVALGAKPYKEEIEDL---KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLL 2499
Query: 1359 KEELKE-KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY--DEEKCELLDQVQ 1415
+E L+ ++ + +S+ + TD Q N + I K E L ++
Sbjct: 2500 RENLRRSQQAQDTSVISEHTD--PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
L + + L K+K L SN+ WK++ R Q T
Sbjct: 2558 KLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVT 2601
Score = 107 bits (267), Expect = 1e-22
Identities = 193/964 (20%), Positives = 390/964 (40%), Gaps = 121/964 (12%)
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTT---KVKEALLIKTCTVSELEAQLRQLTE 1283
L + + IN SK IL +T + +T T + + + +
Sbjct: 272 LSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKN 331
Query: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIE--SLVTEKEALQKEGGNQQQAASEKESCI 1341
+S +A L+ +I +K +E SL T +A++K+ Q E++ +
Sbjct: 332 TPYVNEVSTDEAL--LKRYRKEIMDLKKQLEEVSLETRAQAMEKD---QLAQLLEEKDLL 386
Query: 1342 TQLKKELSENINAVTL------MKEELKEKKV--------EISSLSKQLTDLNVQLQNSI 1387
+++ E EN+ + + +++ELK K+ +I+ + + +I
Sbjct: 387 QKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNI 446
Query: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK- 1446
+ + +I+ LR + DE C D S +DTLS+ + + ++ + N SE
Sbjct: 447 TTKTHKLSINLLR-EIDESVCSESDV---FSNTLDTLSEIEWNPATKLLNQENIESELNS 502
Query: 1447 -KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
+ ++ + ++ELK KE + DE L ++ Q + +++
Sbjct: 503 LRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
Query: 1506 KSKMEKKESNLETELKSQTARIMELEDHIT--QKTIEIESLNEVLKN--YNQQKDIEHKE 1561
E +LE EL S+ + E ED I Q+ I+ + L + + Y+ + + K+
Sbjct: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKSKEE 1620
+ Q L + + + + E L EN ++ EL T K++E+ +S+ E
Sbjct: 623 MKQTLFDAETVALDA-----KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLE 677
Query: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS-ELNT 1679
K ++ LE E + E+ + + K LL +E +G + L ELN
Sbjct: 678 AKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLE------LEGKITDLQKELNK 731
Query: 1680 KLQERE--REVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
+++E E RE IL +LKS+ S V R K + Q++++ + ++
Sbjct: 732 EVEENEALREEVILLSELKSLPSE------VERLRKEI-----QDKSEELHIITSEKDKL 780
Query: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE-RLIKLEHAEAKQHEDQSMIGH 1796
S + + + LL+ +G+ K++ ++ + QE + K H + +Q
Sbjct: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ--------- 831
Query: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
KY +++ + N + Q + N+ + QK L K
Sbjct: 832 ----------KYKMVLEE---------NERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKP--TELLEENTEEKSKSHLVQ 1914
+EL R+ + EME+L + E + Q R K TE L++ EE
Sbjct: 873 QELQE-KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE-------- 923
Query: 1915 PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI-------VRLQKDLRMLR---KEHQQEL 1964
+ + + +DL+ + E+ +L +I + Q+ LR K+HQ+ +
Sbjct: 924 ---VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Query: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQL-AQKEQELEMTIKETINKA 2023
LK + +E + E+ E K K + + L A+ Q L +K+
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
Q+ + L + E Q+L+ + + + LK K E+ +EE+ +L+ Q E
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 2084 LQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143
+ ++ +++E + E++ +L +K+ + QE ++Q+ N+++ + +
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL-------QEKQQQLLNVQEEMSEM 1153
Query: 2144 EKNV 2147
+K +
Sbjct: 1154 QKKI 1157
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 295 bits (756), Expect = 3e-79
Identities = 476/2200 (21%), Positives = 930/2200 (42%), Gaps = 287/2200 (13%)
Query: 69 VPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLV 128
+P+ ES + KE +S E RTS SLN ++ + D D A +
Sbjct: 625 MPNEESSLPAVEKEQ----ASTEHQSRTSEEISLNDAGVELKSTKQD--GDKSLSAVPDI 678
Query: 129 GNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRR 188
G E+L ++ +E + K Q I ++ D+ +
Sbjct: 679 GQCHQDELERLKSQILELELNFH---------------------KAQEIYEKNLDEKAKE 717
Query: 189 IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ--TQVSLLKQRLRNGPMNVDVLK 246
I+ L + ++ ++ + F A EE+DQ +S ++ + V+ L+ +++ MN+ +
Sbjct: 718 ISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAE 777
Query: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV-------KRQENLLKRCK 299
+L+ +++ E +E + +E LQ + Q L++ +
Sbjct: 778 RQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837
Query: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
+Q+ + + + +++E Q L + K+L + + +L+ + + ++Q
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQ-KELEITKMDQLLLEKKRDVETLQQTI 896
Query: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
++K + E M E + EE L IK + Q L +E + E+ E +
Sbjct: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS 956
Query: 420 LSTAQKTEE---ARRKLKAEMDEQIKTIEKTSEEERISLQ----------QELSRVKQEV 466
Q +E A + K E+ + ++K +E+ + LQ Q +SR+++E+
Sbjct: 957 SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL 1016
Query: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE-REFQEQMKVALEKSQSEYLKI 525
++ +S +E + E E ++ +E ++K T + +E + +K + + + E I
Sbjct: 1017 ANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHI 1076
Query: 526 SQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
K+ +E LA EE Q +A++ + L+D + + + I E ++ ++K + N +
Sbjct: 1077 --RKDLEEKLAAEE---QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Query: 586 QSKDLAVHLEAE----------KNKHNK----EITVMVEKHKTELESLKHQQDALWTEKL 631
S +V L E ++H K E + +EK K +L+ K Q+AL T +
Sbjct: 1132 ASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ--KKLQEAL-TSRK 1188
Query: 632 QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL-ESL- 689
+LK+ + E LRE+ +Q+K+ + +E + E NE ++L Q ++ ES+
Sbjct: 1189 AILKKAQEKE-RHLREELKQQKDDYNRLQEQFDEQSKE--NENIGDQLRQLQIQVRESID 1245
Query: 690 ----SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI------ 739
S++ E + LEE L +Q + LE+ + H + ++
Sbjct: 1246 GKLPSTDQQESCSSTPGLEEPLFKATEQ-HHTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
Query: 740 --IKEH--EVSIQRTEKALKDQINQLELLLKERD-----KHLKEHQAHVENLEADIKRSE 790
IK E+ ++ E LK EL K + + + + +E+L+ +E
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
Query: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
+ KL+ Q Q A E + + +L +LQ+ + E + L+ Q++E EA
Sbjct: 1365 VHAESLQQKLESSQ-LQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
Query: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL-TQVYESKLE-DGNKEQEQTKQILVE 908
+ TE+ + ++ L QLE Q E ++++K L ++ E K + + E+ + KQ +
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNE---EYETKFKNQEKKMEKVKQKAKE 965
K L R+ KE + L ++LS +I L + + E++ Q K+ + V +
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
Query: 966 MQETLKKKLLDQEAKLKK--------ELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
+QE K + + + L + E ALE ++K+ K +E +++ S
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
Query: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWE--KKLNQQAEEL----------QEIHEIQ 1065
+++ E L + + N+ I + + Q+ +EL ++ E Q
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 1066 LQEKEQEVAELKQKILLFGCEKE----EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
LQE EQE+ E+K+K+ F K+ E+ +E L+ E T E E L +A
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA- 1722
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK-- 1179
S+ ++ ++K E L + E L E++ +LK E + K + L + K
Sbjct: 1723 --SMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780
Query: 1180 ----TTDEEFQSLK-SSHEKSNKSLEDK-----------------SLEFKKLSE--ELAI 1215
T+E QS+ + E+ + S+ + S +F E
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 1216 QLDICCKKTEALLE--AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Q+D ++ L E K E ++ N +LS+IS ++E + +
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 1274 LEAQLRQLT-------EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
++ +L ++T EE++ L ++ +QL E I + D+ + E L+ E
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLE---ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 1327 GGNQQQAASEKESCITQLKKE---LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
N ++ SE E QL KE + I L K + +K+ S +K+L +L
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL---- 2013
Query: 1384 QNSISLSEKEAAISSLRK---QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
L EK+ + L+K +Y E+ L V+ L F + E LE +
Sbjct: 2014 -----LKEKQQEVKQLQKDCIRYQEKISALERTVKALEF----VQTESQKDLEITKENLA 2064
Query: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD-CLK 1499
+ E +KKAQ+ + + + Q + + + +++ KE + Q K+ D L+
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559
+E + K K++ N++ +L + + LE+ I + + + ++ ++ + D
Sbjct: 2125 RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV 2184
Query: 1560 KELVQKLQHFQELGEEKDNRVKEA--------------EEKILTLENQVYSMKAELETKK 1605
+L + L +++D + EA EE+I E+ +K +L
Sbjct: 2185 TQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMS 2244
Query: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665
+E + +++ E + + E + ++E +L++K + K+LLSQ+EE
Sbjct: 2245 IHMEELKINISRLEHDKQIWESKAQTE-----VQLQQKVCDTLQGENKELLSQLEETRHL 2299
Query: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
Y +++ L++L ++L+ + ++ L L+ + + N+ Q+EAD
Sbjct: 2300 Y-HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKG----------NLEGIIRQQEAD 2348
Query: 1726 SQGCVQKTYEEKISVLQ--RNLT---------EKEKLLQRVGQEKEETVSSHFEMRCQYQ 1774
Q + +YE+ + LQ R LT +++K++ + ++E + E+R Q+
Sbjct: 2349 IQNS-KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE--KEGGKNNIQAKQNLE 1832
+ + +LE+ +++ E+ + LEE+NKK Q +E K K NIQ K L+
Sbjct: 2408 KEIKELENLLSQEEEENIV-------LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 1833 N--------------VFDDVQKTLQEKELTC-----QILEQKIKELDSCLVRQKEVHRVE 1873
+ + D Q+ L+E+ L+ Q++++ E ++ L + R
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQ-LEERHLSIILEKDQLIQEAAAE-NNKLKEEIRGLRSH 2518
Query: 1874 MEELTSKYEKLQA--LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
M++L S+ KL A +Q + N+ + + ++ + L Q K L N A+ LE K
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK---LEEK 2575
Query: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ-EREEKIKQEQEDLELKH 1990
L +E + L + LQ++ + L K E+E LK Q R+ QE+ L L H
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSK----EIESLKVSISQLTRQVTALQEEGTLGLYH 2631
Query: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
QL KE+E+ + + +Q+ AEL E + KK+ E +D
Sbjct: 2632 ------------AQLKVKEEEVH-RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678
Query: 2051 DLKRTAKRYEE---ILDAREEEMTAKVRDLQTQLEELQKK 2087
LK+ K I+ E +V +L L E+++K
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Score = 280 bits (715), Expect = 1e-74
Identities = 482/2284 (21%), Positives = 970/2284 (42%), Gaps = 333/2284 (14%)
Query: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
D++ + + + + + AE LV + +++ +Q L++ + +L R + +
Sbjct: 39 DMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ-LQQKDEALQEERKAADNKIKKLK 97
Query: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKH----LQEEFDAS-----LEE 216
+ K KL + ++ + L E Q ++Q KH +EE + L+E
Sbjct: 98 L--HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155
Query: 217 KDQYISVLQTQVS------------------LLKQRLRNGPMNVDVLKPL---PQLEPQA 255
K++ IS LQ Q++ ++KQ+L+ + L+ Q E A
Sbjct: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
Query: 256 EVFTKEENPESDGEPVVEDG------TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
+ +E++ + + + + T +QQ+++ + L+ +E++ +
Sbjct: 216 QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
Query: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
LL E A +++ Q+L++++ H + + T+ ++K L+E++E + +AE
Sbjct: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME----LEVAER 331
Query: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
K H E + L EQ E++ +A ELE S +
Sbjct: 332 KLSFHNLQE------------------EMHHLLEQFEQAGQAQ-AELESRYSALE----- 367
Query: 430 RRKLKAEMDEQ---IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH- 485
+K KAEM+E+ I +++KT +E LQ +K + +++ +E+ + Q +
Sbjct: 368 -QKHKAEMEEKTSHILSLQKTGQE----LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 486 -EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-----LEE 539
E +L +K +E+++ L R +Q + A + S + + +E++A + E
Sbjct: 423 LEDQLQQKSKEISQFL---NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVE 479
Query: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELES---SLEKSLQENKNQSKDLAVHLEA 596
LE +K A+L S +L +L+ E E ++I LE+ + E + ++ D+A +
Sbjct: 480 LENEKGALLL-SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
Query: 597 EKNKHNKEI--TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ-TEMEKLREKCEQEK 653
+ +++ +KHK L ++A E++ LK Q Q E+ + +K
Sbjct: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEA--QEEIAFLKLQLQGKRAEEADHEVLDQK 596
Query: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KLEEELSV-- 709
E + E I ++ E T + + E SL + E H + EE+S+
Sbjct: 597 EMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLND 656
Query: 710 ----LKDQTDKMKQELEAKMDEQKNHHQ--QQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
LK + L A D + H +++ S I E E++ + ++ + +++
Sbjct: 657 AGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK 716
Query: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
+ ++ ++E + + +N + E Q +++ S + Q K E LA+
Sbjct: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVKQLEMNLAE 775
Query: 824 LQ-QKLLDLETERI---LLTKQV--AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
+ Q+ LD E++ LLT+Q+ +EA+ KDV +++ + ++ D+ Q +Q S +
Sbjct: 776 AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV--KIEVLQNELDDVQLQFSEQ-STL 832
Query: 878 EQKVKSLTQVYESKLEDG-------NKEQEQTKQILVEKENMILQMRE---GQKKEIEIL 927
+ ++S Q ES++ +G + + E+ Q L +KE I +M + +K+++E L
Sbjct: 833 IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETL 892
Query: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987
Q + K+ + ++ K ++ + + K ++E L LL + + KKE
Sbjct: 893 QQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL--NLLSRAEEAKKEQVE 950
Query: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRL--ETNQKEQIESLTEVHRRELNDVIS 1045
E+S KQ +M Q + + L E Q+++ ++R+EL +S
Sbjct: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS 1010
Query: 1046 IWEKKL-NQQAEELQEIHEIQLQ----EKEQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100
E++L N + E +EI + + E+++E E +K + C++ E+ +LK+
Sbjct: 1011 RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI-----YLKQT 1065
Query: 1101 GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE- 1159
+++ L +++ L++K A E + +A ++++ L + LQ ++ E
Sbjct: 1066 ISEKEVELQHIRKDLEEKLA-------AEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118
Query: 1160 ----LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
K++ + + +K T S E LE+K L +K E+L
Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178
Query: 1216 QLDICCKKTEALL------EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
+L +A+L E E + N + + + + L
Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
Query: 1270 TVSE-LEAQLRQLTEEQNT-----LNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
V E ++ +L ++++ L +AT Q + ++ D S + AL
Sbjct: 1239 QVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL 1298
Query: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Q Q A KE I K EL +++ T EL +K E+ L +Q+ +++
Sbjct: 1299 QGGTSVAQIKAQLKE--IEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQGLEI 1353
Query: 1384 QNSISLS-EKEAAISSLRKQYDEEKCEL--LDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
++ ++S E E SL+++ + + ++ L+ +++L K+D L K E V S
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413
Query: 1441 KFSEWK---KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
+ SE + K Q+ + ++ +K L QLE+++K E DE+I L+ EL + ++ +
Sbjct: 1414 QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK---EHDERIKQLQVELCEMKQKPEE 1470
Query: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI 1557
+ GE K ++++K K L++ ++ IE L + L + Q
Sbjct: 1471 I-GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
++KE L L EE+D + E + + LENQ S+ + E+ K LE + +
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSL--LENQ--SLSSSCESLKLALEGLTEDKEK 1585
Query: 1618 KEEELKALEDRLESESA---AKLAELKRKAE----------QKIAAIKKQLLSQMEEKEE 1664
+E+++L+ +ES K EL+++ E + I+ + + +EK+E
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE 1645
Query: 1665 QYKK--GTESHLSELNTKLQEREREVHILEEKL-KSVESSQSETLIVPRSAKNVAAYTEQ 1721
Y K TE++ E +LQE E+E+ ++EK+ K +S Q + L + + A
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHP 1705
Query: 1722 EEADSQGCVQKTYEEKISV---LQRNLTEKE---KLLQRVGQEKEETVSSHFEMRCQYQE 1775
++ C++ S+ L+R E E K Q + EK+ +++ Q +
Sbjct: 1706 AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG 1765
Query: 1776 RLIKLEHAEAKQHED----------QSMIGHLQEE------------------------- 1800
+ K + EA + D QS+ G +E+
Sbjct: 1766 NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAV 1825
Query: 1801 -------------LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF-------DDVQK 1840
L++ ++ I EK+ K Q +N +N D K
Sbjct: 1826 SKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK 1885
Query: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
LQE+ +L Q+I+E S + + KE E ++L + + L +++G
Sbjct: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL--MNQLAELNG--SIGNYC 1941
Query: 1901 EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML---- 1956
++ T+ + K+ L +E++ +L+ ++ E EKQ+L KE +++ ++R
Sbjct: 1942 QDVTDAQIKNEL--------LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Query: 1957 ---------RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMR-----EFN 2002
K H +EL+ L KE QE +KQ Q+D +++ + L R EF
Sbjct: 1994 IQGAQKEPGNKSHAKELQELLKEKQQE----VKQLQKDC-IRYQEKISALERTVKALEFV 2048
Query: 2003 TQLAQKEQEL-EMTIKETINKAQEVEAE------LLESHQEETNQLL-------KKIAEK 2048
+QK+ E+ + + + + ++ +AE LL+ Q E ++L K++
Sbjct: 2049 QTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSN 2108
Query: 2049 DDDLKRTAKRYEEILDAREEEMTAK-VRDLQTQLEELQKKYQQKLEQEENPGNDNVT--- 2104
+ +K K+ +E L+ R E+ K +++ + E+L ++K+ EE G VT
Sbjct: 2109 KESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK 2168
Query: 2105 ----IMELQ-------TQLA-----------QKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
+ +LQ TQLA + +I ++K E++F + I + E+ ++
Sbjct: 2169 KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 2143 YEKN 2146
E N
Sbjct: 2229 KEDN 2232
Score = 280 bits (715), Expect = 1e-74
Identities = 440/2198 (20%), Positives = 945/2198 (42%), Gaps = 328/2198 (14%)
Query: 134 LNKEQLIQRLRRMERSLSSYRGKYSELV----TAYQMLQREKKKLQG----ILSQSQDKS 185
+N+++L+QR+ R+E L++ + + + + T ++ +K+ + + S+ Q+
Sbjct: 1000 INRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE 1059
Query: 186 L---RRIAELREELQ---MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGP 239
+ + I+E ELQ D + K +E+F A +++ +Q + Q+ LL+ +
Sbjct: 1060 IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQ 1119
Query: 240 M----------------NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLET 283
+V ++K + P ++ PE + + + + + +
Sbjct: 1120 AIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK 1179
Query: 284 LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTK 343
LQ+ + ++ +LK+ +E + +E+ + LQEQ DE+ +E E I D + +
Sbjct: 1180 LQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD----QLRQ 1235
Query: 344 LITQLRDA---------------------KNLIEQLEQ---------------------- 360
L Q+R++ + L + EQ
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295
Query: 361 ---DKGMVIAETKRQMHE-----------------TLEMKEEEIAQLRSRIKQMTTQGEE 400
G +A+ K Q+ E L K EE+ QL+ +I + + E
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES 1355
Query: 401 LREQKEKSERAAFEELEKALSTAQ---KTEEARRKLKAEMDEQIKTIEKTSEE------E 451
L+ ++E A E L++ L ++Q E R+L+ ++DE K I K E+ +
Sbjct: 1356 LKTVSHEAEVHA-ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 452 RISLQQELSRVKQEVVDV--MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE----- 504
+ L++++ E+++ + K+ Q+ K H++ + + + EL + Q E
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 505 ----REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560
++ Q +++ AL S+ E LK ++ +++ SLA +E K+ L + E+++ +
Sbjct: 1475 SRAKQQIQRKLQAAL-ISRKEALKENKSLQEELSLARGTIERLTKS-LADVESQVSAQNK 1532
Query: 561 EAETYRTRILELE-------SSLEKSLQENKNQSKDL-AVHLEAEKNKHNKEITVMVEKH 612
E +T R+ L+ + +++SL EN++ S ++ L E +KE V K
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV---KE 1589
Query: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR------EKCEQEKETLLKDKEIIF-Q 665
L+S K + W EK + L+++Y+ ++ E+ + E + ++K+ ++ +
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 666 AHIEEMNEKTLEK-LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAK 724
E N+K EK L + E+E + ++ + K++ ++++ L+++ D+++ E+
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK---QQKILELEEENDRLRAEVHPA 1706
Query: 725 MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA 784
D K + + S E ++R + + + + L+ E+D +E Q +E
Sbjct: 1707 GDTAKECMETLLSSNASMKE-ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG 1765
Query: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
++ + +A+ K D + + T E T++ + +Q L + T R ++ V
Sbjct: 1766 NVSKQAN--LEATEKHD---NQTNVTEEGTQSIPGETE--EQDSLSMST-RPTCSESVPS 1817
Query: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
++ V + +H ++ + +QQ++ ++++++ + LE+ ++ ++ Q
Sbjct: 1818 AKSANPAVSKDFSSHD-EINNYLQQID----QLKERI--------AGLEEEKQKNKEFSQ 1864
Query: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
L ++N +L + E+++L ++++ +++LN++ + + ++ K+K+ A+
Sbjct: 1865 TLENEKNTLLSQISTKDGELKMLQEEVT----KMNLLNQQIQEEL----SRVTKLKETAE 1916
Query: 965 EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
E ++ L+++L++Q A+L + N +++ + Q ++LE N + VS LE
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKNELLESEMKN---LKKCVSELEEE 1971
Query: 1025 QKEQIESLTEVH---RRELNDVISIWEKKLNQQ--AEELQEIHEIQLQEKEQEVAELKQK 1079
+++ ++ T+V R+E + I +K+ + A+ELQE+ L+EK+QEV +L++
Sbjct: 1972 KQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL----LKEKQQEVKQLQKD 2027
Query: 1080 ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKL 1139
+ + + + + + L+ + L +E L Q H + K L+
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
Query: 1140 EVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
+ + + L +N L+++L K + + K+K +L +L+ +E+ K + ++ +
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147
Query: 1199 LEDKSLEFKKLSEELAIQLDICCKKTEAL---LEAKTNELINISSSKT------NAILSR 1249
L + + ++ E+ + L+ K+ + L L++ +L + S + + ++
Sbjct: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
Query: 1250 ISHCQHRTTKV----KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ 1305
+ + + +E + +K S L+ QLRQ++ L I+ + H + Q
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH-----DKQ 2262
Query: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
I KA E + +K +G N+ +L +L E + + EL +
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGENK------------ELLSQLEETRHLYHSSQNELAKL 2310
Query: 1366 KVEISSLSKQLTDLNVQLQNSIS--------LSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
+ E+ SL QLTDL+ L+ + ++EA I + + Y++ + +L
Sbjct: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL-----QA 2365
Query: 1418 SFKVDTLSKEKISALEQ--VDDWSNKFSEWKKKAQSRFTQHQNTVKELQ----------I 1465
S ++ + E+I+ EQ + S K + QH +KEL+ I
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
Query: 1466 QLELKSKEAYEKDEQ----INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521
LE ++K+A +K Q + +K+E QQ + D M ++ ++ + + +
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485
Query: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK-------ELVQKLQHFQELGE 1574
+ I+E + I + E L E ++ D + EL+Q + ++
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545
Query: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
KD++ K+ E L ++ + A+LE K KE E N ++ L+ + L E
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605
Query: 1635 AKLAELKRKAEQKIAAIKKQLL----SQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690
+ + + Q A ++ L +Q++ KEE+ + LS L + Q+R E
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR-----LSALFSSSQKRIAE--- 2657
Query: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
LEE+L V+ ++ + +A +T EE+++ L R+L E E+
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
Query: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
L V +E + + +++ Q+ H EEL+E +KY
Sbjct: 2718 KLLMVTKENKGLTA--------------QIQSFGRSMSSLQNSRDHANEELDELKRKYDA 2763
Query: 1811 IVAQHVE-KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
+ + + KE G N + L + T + + L Q++ D L+
Sbjct: 2764 SLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQ 2823
Query: 1870 HRVEMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL 1928
++ S + + +LQ + D E ++ E K +S QP S A+ L
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRS-AAQP---STSPAEVQSL 2879
Query: 1929 EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
+ ++ + ++ +L KE+ LQ+ + +E EL LK + QE ++K K Q
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQINQE-ITELHPLKAQL-QEYQDKTKAFQ----- 2932
Query: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
+++ +R+ N + +L M ++ E+ E +E Q L I++K
Sbjct: 2933 ----IMQEELRQENLSWQHELHQLRM---------EKSSWEIHERRMKE--QYLMAISDK 2977
Query: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
D L + + ++R +Q + L+ +YQ++ E + D +
Sbjct: 2978 DQQLSHL------------QNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVY 3025
Query: 2109 QTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKN 2146
+T+L + T ++DS LKE IH E R+++ N
Sbjct: 3026 ETELLR--TQLNDS-LKE------IHQKELRIQQLNSN 3054
Score = 242 bits (617), Expect = 3e-63
Identities = 389/1911 (20%), Positives = 817/1911 (42%), Gaps = 258/1911 (13%)
Query: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREK-------KKLQGILSQSQDKSLRRI 189
++L + + + E +S G+ SE A +Q E K L L + RI
Sbjct: 1395 DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI 1454
Query: 190 AELR----------EELQMDQQAKKHLQEEFDASLEEKDQYISV---LQTQVSLLKQRLR 236
+L+ EE+ + +AK+ +Q + A+L + + + LQ ++SL + +
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296
+ K L +E Q KE++ T + L LQ+ + +
Sbjct: 1515 R------LTKSLADVESQVSAQNKEKD------------TVLGRLALLQEERDKLITEMD 1556
Query: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE 356
R QS C L E L E ++ ++E+E +K +AE T+ + ++ + E
Sbjct: 1557 RSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1616
Query: 357 QLEQDKGMVIAETKRQMH--ETLEMKEEEI--------AQLRSRIKQMTTQGEELREQKE 406
L Q V E +R H E + +++E+ A + KQ+ +E+ E KE
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
K + A + +K L ++ + R ++ D + +E T S+++EL RVK E
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME-TLLSSNASMKEELERVKMEY 1735
Query: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQ---ELTKKLQTREREFQE-QMKVALEKSQSEY 522
+ + K + +++ L E+ K Q ++K+ E + Q V E +QS
Sbjct: 1736 -ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS-- 1792
Query: 523 LKISQEKEQQESLALEELELQKKAILTESE-----NKLRDLQQEAETYRTRILELESSLE 577
I E E+Q+SL++ +++ + +K E Y +I +L+ +
Sbjct: 1793 --IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850
Query: 578 KSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
L+E K ++K+ + LE EKN ++ + T+ LK Q+ + K+ +L QQ
Sbjct: 1851 -GLEEEKQKNKEFSQTLENEKN-------TLLSQISTKDGELKMLQEEV--TKMNLLNQQ 1900
Query: 638 YQTEME---KLREKCEQEKETLLKDKEIIFQAHIEEMNEKT---LEKLDVKQTELESLSS 691
Q E+ KL+E E+EK+ D E + E+N + + Q + E L S
Sbjct: 1901 IQEELSRVTKLKETAEEEKD----DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 692 ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
E+ + K +LEEE L + K++ E+ + E+ Q++ + K H +Q
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN--KSHAKELQELL 2014
Query: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
K + ++ QL+ K +Q + LE +K E ++ L++ + +
Sbjct: 2015 KEKQQEVKQLQ-------KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
E K + +LA + L D ++E + +A+ KK++ + ++ K Q++ + LE
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEA---ARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK-KEIEILTQK 930
++ + E+K + + KL+ +E+ ++ + E +Q+ +K KE++ L +
Sbjct: 2125 RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE-----IQVTLNKKDKEVQQLQEN 2179
Query: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL 990
L + + + + ++++ +++ K+ ++ + ++ K ++E +LK E+
Sbjct: 2180 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK--EEEIRLK---EDNCS 2234
Query: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE-QIESLTEVH-RRELNDVISIWE 1048
L + +Q + M E+ +SRLE +++ + ++ TEV ++++ D +
Sbjct: 2235 VLKDQLRQMSIHMEEL--------KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 1049 KKLNQQAEELQEIH---EIQLQEKEQEVAELKQKIL-----LFGCEKEEMNKEITWLKEE 1100
K+L Q EE + ++ + +L + E E+ LK ++ L C++++ N E ++E
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
Query: 1101 GVKQDTTLN----------------ELQEQLKQKSAHVNSLAQD-ETKLKAHLEKLEVDL 1143
Q++ + L E++ K + SL E ++ + +L
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 1144 NKSLKE-NTFLQEQLVELKMLAEEDKR---KVSELTSKLKTTDEEFQSLKS---SHEKSN 1196
+K +KE L ++ E +L EE+K+ K ++L LKT +E K+ S KS
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 1197 KSLE---DKSL-EFKKLSEELAIQLDICCKKTEALLEA--KTNEL-------------IN 1237
SL+ D+ + ++++L E L I +K + + EA + N+L +N
Sbjct: 2467 SSLQNDRDRIVGDYQQLEER---HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523
Query: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV------------SELEAQLRQLTEEQ 1285
++K +A L + ++ +K++ + V ++LE +L++ E
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN 2583
Query: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG--GNQQQAASEKESCITQ 1343
L SF + ++ +I+S+K I L + ALQ+EG G KE + +
Sbjct: 2584 EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR 2643
Query: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403
L S + + ++EEL + E +K++ ++ +L+ + +A I +
Sbjct: 2644 LSALFSSSQKRIAELEEELVCVQKE---AAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
Query: 1404 DEEK-CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE 1462
EE+ EL + ++ K+ ++KE Q+ + S Q+ + E
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS----SLQNSRDHANEELDE 2756
Query: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
L+ + + KE + EQ L +E ++ + E+ S +EK L +L S
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK----LNQQLLS 2812
Query: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN---- 1578
+ +++ L + +++S ++ + + ++D L +L+ F++ E K
Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERD----HLWNELEKFRKSEEGKQRSAAQ 2868
Query: 1579 ------RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV-------------KSKE 1619
V+ ++ + +L+N + EL+ +++ +N + + K
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
Query: 1620 EELKALEDRLESESAAKLAELKRKAEQKIA------AIKKQLLSQMEEKEEQYKKGTESH 1673
+ + +++ L E+ + EL + +K + +K+Q L + +K++Q SH
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL-----SH 2983
Query: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
L L +L+ + L K++ + ET P ++N+ TE +++
Sbjct: 2984 LQNLIRELRSSSSQTQPL--KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEI 3041
Query: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
+++++ + Q N + L E++ T+S C + L E +QH +
Sbjct: 3042 HQKELRIQQLNSNFSQLL------EEKNTLSIQL---CDTSQSL-----RENQQHYG-DL 3086
Query: 1794 IGH---LQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC 1849
+ H L+++++E + ++ VA +E KN + K + E + + Q + ++ C
Sbjct: 3087 LNHCAVLEKQVQELQAGPLNIDVAPGAPQE--KNGVHRKSDPEELREPQQSFSEAQQQLC 3144
Query: 1850 QILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
Q++ EL L +++ L+ E+++ L+ + + T ++
Sbjct: 3145 N-TRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPII 3194
Score = 232 bits (592), Expect = 3e-60
Identities = 391/1806 (21%), Positives = 769/1806 (42%), Gaps = 314/1806 (17%)
Query: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD----LQQEAETYRTRILE 571
++S E+ +QE Q+ E+L ++ K I+ + + +L+ LQ+E + +I +
Sbjct: 36 QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKK 95
Query: 572 LE-------SSLEKSLQENKNQ-----------SKDLAVH--------LEAEKNKH---- 601
L+ +SL K ++E K Q + L+ H +E EK KH
Sbjct: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155
Query: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL--------REKCEQEK 653
+E+ ++ T+ ++ + Q + E+ ++KQQ Q + E + + + EQ
Sbjct: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
Query: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ 713
+ ++++K+ F+ + ++ L+ V Q ++E+ + VL+ + + EE V + Q
Sbjct: 216 QQVVREKDARFETQVRLHEDELLQL--VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
Query: 714 -TDKMKQELEAKMDEQKNH-HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKH 771
D ++QEL A EQ+N QQ+ + EH ++ + + ++LL++ +
Sbjct: 274 VVDLLQQELTAA--EQRNQILSQQLQQMEAEHNT----LRNTVETEREESKILLEKMELE 327
Query: 772 LKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ----LAQLQQK 827
+ E + NL+ ++ + +QA +S SA ++ KA E+ + LQ+
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV------ 881
+L++ L Q +++ K + + Q++D +QQ K+ S+ ++
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 882 ----KSLTQVYE---SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
S VY + + N Q + + +E E L + + +E++ +KLS++
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
Query: 935 EDSIHILN------------------------------EEYETKFKNQEKKMEKVKQKAK 964
+ N + E F + K++ + + K
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
Query: 965 EMQETL---------------KKKLLDQE------------AKLKKELENT--------- 988
E QE + ++LDQ+ K+K LE+T
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
Query: 989 ------ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK-EQIESLTEVHRRELN 1041
A+E Q + ++ E N AG+ ++ + ++ + + + H+ EL
Sbjct: 628 EESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
Query: 1042 DVIS-IWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100
+ S I E +LN + QEI+E L EK +E++ L Q I F + + T L EE
Sbjct: 688 RLKSQILELELN--FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
Query: 1101 ------GVKQDTTLNELQEQLKQKSAHV-----------NSLAQDETKLKAHLEKLEVDL 1143
VK+ + + EL+ Q+KQ ++ S + L + L ++
Sbjct: 746 RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD-------EEFQSLKSSHEKSN 1196
+ LQ +L ++++ E + L S+L+ + E + + S E+ +
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAI---------- 1246
++L K LE K+ ++L ++ + + +E K ++ IS S T +
Sbjct: 866 QALSQKELEITKM-DQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSL 924
Query: 1247 ---LSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL-NISFQQATHQLE-- 1300
+ + + ++ +EA + +E+ + L+Q +E + IS ++ H+ +
Sbjct: 925 GVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLL 984
Query: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
+KEN+ + K +L+ KE LQ+ +++ A+ K+ + KKE+ + ++E
Sbjct: 985 KKENEQRKRKLQ-AALINRKELLQRVSRLEEELANLKD----ESKKEIPLSETERGEVEE 1039
Query: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
+ + K+ ++ + ++ + L+ +I SEKE + +RK EEK +Q Q L +
Sbjct: 1040 DKENKEYSEKCVTSKCQEIEIYLKQTI--SEKEVELQHIRKDL-EEKLAAEEQFQALVKQ 1096
Query: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT--------VKELQIQLE--LK 1470
++ ++K + Q+D + SE + Q T + + VKE +
Sbjct: 1097 MNQTLQDKTN---QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
Query: 1471 SKEAY--EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
S E + E +E+I L++E +Q K+ + K ++KE +L ELK Q
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
L++ +++ E E++ + L+ Q I+ +E + G+ +E+
Sbjct: 1214 RLQEQFDEQSKENENIGDQLR----QLQIQVRESID--------GKLPSTDQQESCSSTP 1261
Query: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE-SESAAKLAEL---KRKA 1644
LE ++ + T+ ++ S E+ AL+ ++ A+L E+ K +
Sbjct: 1262 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1321
Query: 1645 EQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
E K+++ +L + EE +E+ K+G E + L T E E L++KL ES
Sbjct: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLE--IESLKTVSHEAEVHAESLQQKL---ES 1376
Query: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
SQ + + + E ++ S+ EE +S L L+EKE L ++ E
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISK------KEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 1761 ETVSSHFEMRCQYQERLIKLEHA----EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816
E QE LIK H +AK+H+++ I LQ EL E +K
Sbjct: 1431 E------------QEDLIKALHTQLEMQAKEHDER--IKQLQVELCEMKQK--------- 1467
Query: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
+E G+ + +AKQ +Q+ LQ ++ ++ +KE + L + + R +E
Sbjct: 1468 PEEIGEES-RAKQ-------QIQRKLQAALIS---RKEALKE-NKSLQEELSLARGTIER 1515
Query: 1877 LTSKYEKLQALQQMDGRNKPT-----ELLEENTE----EKSKSHLVQPKLLSNMEAQHND 1927
LT +++ + K T LL+E + E +S L L S+ E+
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES---- 1571
Query: 1928 LEFKLAGAEREKQKLGKEIVRLQK-------DLRMLRKEHQQELEILKKEYD-------- 1972
L+ L G +K+KL KEI L+ + + KE Q+E EIL + Y+
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER 1631
Query: 1973 -QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031
Q E ++QE+++L K ST + +E QL + EQE+E +KE + K + + + +
Sbjct: 1632 IQHVVEAVRQEKQELYGKLRST-EANKKETEKQLQEAEQEME-EMKEKMRKFAKSKQQKI 1689
Query: 2032 ESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091
+EE ++L ++ D TAK E L + M ++ ++ + E L KK+Q
Sbjct: 1690 LELEEENDRLRAEVHPAGD----TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 2092 LEQEEN 2097
+ ++++
Sbjct: 1746 MSEKDS 1751
Score = 160 bits (404), Expect = 2e-38
Identities = 252/1307 (19%), Positives = 545/1307 (41%), Gaps = 188/1307 (14%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSR-----TSSFTEQLDEGTPNRESG- 56
KK ++ EE+QQL + ++ +++ S ++L E ++
Sbjct: 1962 KKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEV 2021
Query: 57 -----DTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSST 111
D + +K+ +V++L + +KE+L + + +L S
Sbjct: 2022 KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081
Query: 112 ASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREK 171
D D SEA ++ ++ L KE L+ + S+ S QM Q+++
Sbjct: 2082 VLLD---DTQSEAARVLADNLKLKKE-----LQSNKESVKS------------QMKQKDE 2121
Query: 172 KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQE---EFDASLEEKDQYISVLQTQV 228
L+ L Q+++K L+ ++E+L ++ K HL+E E +L +KD+ + LQ
Sbjct: 2122 D-LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN- 2179
Query: 229 SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
L Q FTK + D + ++ ++
Sbjct: 2180 -------------------LDSTVTQLAAFTKSMSSLQDDRD--------RVIDEAKKWE 2212
Query: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
++ + ++ +E I+ ++ C++L + + ++E + +++ ++K T++
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
Query: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS 408
+ + + + L+ + ++++ + H + E+A+L S +K + Q +L EK
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRH-LYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
Query: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
+ E + L + +EA + EQ++T + S E L +E++ +Q+++
Sbjct: 2332 K-----EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS 2386
Query: 469 VMKKSSEE---QIAKLQKLHEKELARKEQELTKKLQTRERE---FQEQMKVALEKSQS-- 520
++ E IA+L++ H+KE+ +EL L E E +E+ K A++K+
Sbjct: 2387 LLSGKEEAIQVAIAELRQQHDKEI----KELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
Query: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
E LK +++ Q+ L+ ++ + + + D QQ E + + ILE + ++++
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAA 2502
Query: 581 QEN---KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
EN K + + L H++ + N N ++ + +++ +L + +D+ + L+V QQ
Sbjct: 2503 AENNKLKEEIRGLRSHMD-DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQ 2561
Query: 638 -------YQTEMEKLREKCE-------------QEKETLLKDKEIIFQAHIEEMN----- 672
Y EKL+E E +EK+ L K+ E + + I ++
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL-KVSISQLTRQVTA 2620
Query: 673 ---EKTL----EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM 725
E TL +L VK+ E+ LS+ S K +LEEEL ++ + K E+E K+
Sbjct: 2621 LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL 2680
Query: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
++ H + E E + +R + +D + ++E L K K A +++
Sbjct: 2681 KKELKHLHHDAGIMRNETETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRS 2739
Query: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ------------------------- 820
+ + A+ +LD + A+ ++ +EQ
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
Query: 821 ---LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
L +L Q+LL + + + L+ Q+ + Q + + + + + L +LEK
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE 2859
Query: 878 EQKVKSLTQVYESKLEDGNKE------QEQTKQILVEKENMILQMREGQKKEIEI----- 926
E K +S Q S E + + Q ++L E +N+ Q + ++ E+
Sbjct: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKA 2919
Query: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK-------AKEMQETLKKKLLDQEA 979
Q+ K + I+ EE + + + ++ +++ + + M+E + D++
Sbjct: 2920 QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQ 2979
Query: 980 KLK------KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033
+L +EL +++ + + Q+ + A+ G + V E + + +SL
Sbjct: 2980 QLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLK 3039
Query: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI--LLFGCEKEEMN 1091
E+H++EL I +Q EE + IQL + Q + E +Q LL C +
Sbjct: 3040 EIHQKELR--IQQLNSNFSQLLEEKNTL-SIQLCDTSQSLRENQQHYGDLLNHC--AVLE 3094
Query: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
K++ L+ + D QE + H S ++ L + + +++ ++
Sbjct: 3095 KQVQELQAGPLNIDVAPGAPQE---KNGVHRKSDPEE-------LREPQQSFSEAQQQLC 3144
Query: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
++++ EL+ L EE++ + + L +E+ + L+ S S+++
Sbjct: 3145 NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRT 3191
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 284 bits (727), Expect = 6e-76
Identities = 488/2292 (21%), Positives = 966/2292 (42%), Gaps = 359/2292 (15%)
Query: 55 SGDTQSFAQKLQLRVPSVESLFRSPIKESLFRS-SSKESLVRTSSRESLNRLDLDSSTAS 113
+G + KLQL S E + + + L S L+++ + D S +
Sbjct: 729 TGQVEDLEHKLQLL--SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 114 FDPPSDMDSEAEDLVGNSDSLNKEQ----------------LIQRLRRMERSLSSYRGKY 157
FD M +++G S+ E+ L R+ +E SL S +
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 158 SELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELRE---ELQMDQQAKKHLQEEFDASL 214
S+L + L + K +++ L +++ +AE + +LQ D A +++ E ++L
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 215 EEKDQYISVL----QTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEP 270
E K++ + +L +T+ + +++ ++ + D LK L L + KE +
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS------- 959
Query: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL 330
S+ +L + QEN KE S ++ L + E+ +DER + +
Sbjct: 960 ------SIISLNKREIEELTQEN--GTLKEINASLNQEKMNLIQKSESFANYIDEREKSI 1011
Query: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
++ D + EK L+ + + N E L Q + ++ + LE E L
Sbjct: 1012 SELSDQYKQEKLILLQRCEETGNAYEDLSQKY-----KAAQEKNSKLECLLNECTSLCEN 1066
Query: 391 IKQMTTQGEEL--REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTS 448
K Q +E +E +E + AF E E+ + + E ++ L++EM + + +
Sbjct: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAE-ERNQNLMLELETVQQALRSEMTDNQNNSKSEA 1125
Query: 449 ---EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
++E ++L++E +++++EV D+++++ EQ+ K+ K + + + + ++ RE
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQEN--EQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 506 E-----FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560
E F+ QM + E +IS + + + LE + K+ L ESE + LQ
Sbjct: 1184 ERNQCNFKPQMDL-------EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH 1236
Query: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
E +T R +LE+S +LQ+ QS++++ + E + K I+ E ++ ++
Sbjct: 1237 ELQTIRG---DLETS---NLQDM--QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA- 1287
Query: 621 HQQDALWT------------EKLQVLKQQYQTEMEKLREKC-------EQEKETLLKDKE 661
H Q +L T E LQ K + TE+ R +C +E LL + +
Sbjct: 1288 HLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Query: 662 II-------------------FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
I+ F E + +L LD + E L+ EV +
Sbjct: 1348 ILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLD-ESNSYEHLTLSDKEVQMHFAE 1406
Query: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
L+E+ L+ + K+ + +M + + Q VDS+ E+ V D + +++
Sbjct: 1407 LQEKFLSLQSE-HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQ 1465
Query: 763 LLLKE---------------RDKHLKEHQAHVENLEAD-----IKRSEGELQQASAKLD- 801
L L+E L + + LE + EG + +D
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525
Query: 802 VFQSY---QSATHEQT---------------KAYEEQLAQLQQKLLDLETERILLTKQVA 843
VF S ++ T ++T + Y + L +L++K+ E++ I+ K++
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM---ESQGIMKNKEIQ 1582
Query: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
E+E ELD L +Q +N + +QK+ S+T ESKL E++QT+
Sbjct: 1583 ELEQLLSSERQELDC-------LRKQYLSENEQWQQKLTSVTLEMESKLA---AEKKQTE 1632
Query: 904 QILVEKENMILQMREGQKKEIEILTQKLSA--KEDSIHILNEEYETKFKNQEKKMEKVKQ 961
Q+ +E E LQ++ +++ ++ L ED+I NE + ++ + E+
Sbjct: 1633 QLSLELEVARLQLQG-----LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTP- 1686
Query: 962 KAKEMQETLKKKLLDQEAKLKKELENTALELSQK---EKQFNAKMLEMAQANSAGISDAV 1018
K Q K D ++K E A++ + + E+ + + + G S+ +
Sbjct: 1687 KHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECI 1746
Query: 1019 SRLETN------------QKEQIESL------TEVHRRELNDVISIWEKKLNQQAEELQE 1060
S L + +E I +L T L VI ++K+ E++E
Sbjct: 1747 SELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE 1806
Query: 1061 I------HEIQLQEK--------------EQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100
+ E+QL K ++E ++L +K+ F C+ +E+ + + E
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE--TSE 1864
Query: 1101 GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
G+ D E+ + +++A+ K +E +L++ E ++ + + L
Sbjct: 1865 GLNSDL---EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
Query: 1161 KMLAE-------------EDKRKVSE-LTSKLKTTDEEFQSLKSSHEKSNK---SLEDKS 1203
+ E E+K+KV L +L E L+ + +K +L+ S
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 1204 LEFKKLSEELAIQLDICC---KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKV 1260
+ K+ ++EL C + EA ++ KT EL+ SS + +L +H Q + +
Sbjct: 1982 EKMKEKTQELESHQSECLHCIQVAEAEVKEKT-ELLQTLSSDVSELLKDKTHLQEKLQSL 2040
Query: 1261 KEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
++ + T ELE Q+ QL +E+ L + +L E + + ++ +E+ + EK
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
+ Q+ + I +L+ + + + E+LKE++ E SL ++ +L
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 1381 VQLQNSISLSEKEAAISSLRKQYDEEKCELL-DQVQDLS-----FKVD--TLSKEKISAL 1432
+LQ +SE+ + L + + + E L Q+++++ F++D TL EK +
Sbjct: 2161 RELQ----MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216
Query: 1433 EQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
+Q+ + + SE K S F ++ +IQ++ +SK A E +L+ +L + N
Sbjct: 2217 KQIQEKQGQLSELDKLLSS-FKSLLEEKEQAEIQIKEESKTAVE------MLQNQLKELN 2269
Query: 1493 KRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN 1552
+ L G+ E K+ + + +E E+H + +IE
Sbjct: 2270 EAVAALCGDQEIMKATEQSLDPPIE-------------EEHQLRNSIE------------ 2304
Query: 1553 QQKDIEHKELVQKLQHFQELGEEKD----NRVKEAEEKILTLENQVYSMKAELETKKKEL 1608
KL+ E E+K ++KE+E L+ +V +++ ELE +
Sbjct: 2305 ------------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK--KQLLSQMEEKEEQY 1666
EH L ++ + E++ L+ ++E + + R E + I+ K+ L+ +KE++
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEG-----MTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
Query: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
E S LQE+E+E ++EK S +T + + + A + +QE +
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEK-SSTAMEMLQTQLKELNERVAALHNDQEACKA 2466
Query: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
+ ++ ++ L+ EK +LLQ + + K + + QE +E + K
Sbjct: 2467 K---EQNLSSQVECLE---LEKAQLLQGLDEAKNNYIVLQSSVNGLIQE----VEDGKQK 2516
Query: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
+ I L+ +++++ + S + VE G++ + +QNLE ++ E E
Sbjct: 2517 LEKKDEEISRLKNQIQDQEQLVSKL--SQVE---GEHQLWKEQNLE-----LRNLTVELE 2566
Query: 1847 LTCQILEQKIKEL-DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN-KPTELLEENT 1904
Q+L+ K L D+ V Q +E E +K +K+ +++++ K TEL E
Sbjct: 2567 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626
Query: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
E K+ +Q +L +L+ L + K +L K+L + E ++ L
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL--------KELTLENSELKKSL 2678
Query: 1965 EILKKEYDQEREEKIKQEQEDLEL-------KHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
+ + K+ E+E K+++E + +L KH + L +++ ++ ++L T K
Sbjct: 2679 DCMHKD-QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL--TSK 2735
Query: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK---RYEEILDAREEEMTAKV 2074
E +Q++E +LL+S +EE N LK + ++LK+T +Y L E K+
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 2075 RDL---QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
+ L QLEE ++ Q++L Q + T + T++ + TT I + K + E
Sbjct: 2796 KLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELK---ETLEE 2852
Query: 2132 QIHNLEDRLKKY 2143
+ ++ L KY
Sbjct: 2853 KTKEADEYLDKY 2864
Score = 254 bits (648), Expect = 9e-67
Identities = 506/2425 (20%), Positives = 981/2425 (40%), Gaps = 381/2425 (15%)
Query: 1 MFKKLKQKISEEQQQL---QQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGD 57
M + L++KI++++ L + LA A + + EQL++ E +
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK-E 594
Query: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117
+++ L+L+ E L S ++S +++ L + S + + ++
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
E + V + +++E L +R + L S + AY LQ++ +
Sbjct: 655 QIKSHEYNERVRTLE-MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE----F 709
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Q K + + +L + +H + + +KD+ L + L+ L++
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 238 GPM----NVDVLKPLPQLEPQAEVFTKEEN--------PESDGEPVVEDGTSVKTLETLQ 285
N D + L + Q + N P E +E S K LQ
Sbjct: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQ 829
Query: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLI 345
RV E L+ K+ ++QC L ++ +++E L + E++ +AE ++ I
Sbjct: 830 NRVDSLEFSLESQKQMNSDLQKQCEELVQ----IKGEIEENLMKAEQMHQSFVAETSQRI 885
Query: 346 TQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQK 405
++L++ + + V+AET LE KE+E+ L +++ T+ E++E K
Sbjct: 886 SKLQEDTSAHQN-------VVAETL----SALENKEKELQLLNDKVE---TEQAEIQELK 931
Query: 406 EKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE---ERISLQQELSRV 462
+ + LE +L Q E K EM I ++ EE E +L++ + +
Sbjct: 932 KSNHL-----LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Query: 463 KQEVVDVMKKSSEEQIAKLQKLHEKELAR-KEQELTKKLQTREREFQEQMKVALEKSQSE 521
QE +++++KS E A EK ++ +Q +KL +R E+ A E +
Sbjct: 987 NQEKMNLIQKS--ESFANYIDEREKSISELSDQYKQEKLILLQR--CEETGNAYEDLSQK 1042
Query: 522 YLKISQEKEQQESLALE----------ELELQKKAILTESENKLRDLQQEAETYRTRILE 571
Y ++ + E L E ELE K+A E + L L E + +LE
Sbjct: 1043 YKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLE 1102
Query: 572 LES---SLEKSLQENKNQSKDLA-------VHLEAEKNKHNKEITVMVEKHKTELESLKH 621
LE+ +L + +N+N SK A + L+ E+NK KE+ ++++++ ++ +K
Sbjct: 1103 LETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKT 1162
Query: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH------IEEMNEKT 675
+ + E + + E E R +C + + L+ KEI ++ +E M
Sbjct: 1163 KHECQNLESEPIRNSVKERESE--RNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Query: 676 LEKLDVKQTELESLSSELS------EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
KL + E E L EL E + +E+S LKD E++A+
Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC------EIDAEEKYIS 1274
Query: 730 NHHQQQVDSIIKEH-EVSIQRTEKALKDQINQLELLLKERDKHLKE-HQAHVENLEADIK 787
H+ H + S+Q T L + E+L E+ + + E + + E + A K
Sbjct: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRK 1334
Query: 788 RSE--------------------GELQQ-----------------ASAKLDVFQSYQSAT 810
+E GEL + + A LD SY+ T
Sbjct: 1335 MAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLT 1394
Query: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
K + A+LQ+K L L++E +L Q ++ ++ ++ T +D+ K + L L
Sbjct: 1395 LSD-KEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNL 1453
Query: 871 EKQNSEMEQKVK--------------------SLTQVYESKLEDGNKEQEQTKQILVEKE 910
++ ++++ SL+ + +S EQ +L E
Sbjct: 1454 RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLE 1513
Query: 911 NMI--------------LQMREGQKKE--------IEILTQKLSAKEDSIHILNEEYETK 948
+ LQ +KE +E L S+ L E+ E++
Sbjct: 1514 GAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQ 1573
Query: 949 --FKNQE-KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK----EKQFNA 1001
KN+E +++E++ ++ + L+K+ L + + +++L + LE+ K +KQ
Sbjct: 1574 GIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQ 1633
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL--Q 1059
LE+ A + L+ + + + TE + N+ I ++ ++ E
Sbjct: 1634 LSLELEVARLQ-----LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKH 1688
Query: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEK---EEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
++H+I ++ +Q++ +KI G K E ++ E +D T + +
Sbjct: 1689 DVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISE 1748
Query: 1117 QKSAHVNSLA-QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
+ N+L D + + L++ + ++ EN L + + E ++ EL
Sbjct: 1749 LSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808
Query: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
SKL + + + + + K + + E LSE+L C E L +T+E
Sbjct: 1809 SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY---FSCDHQELLQRVETSEG 1865
Query: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
+N S + +A S KV ++ + V E +L ++ E+ ++
Sbjct: 1866 LN-SDLEMHADKSSREDIGDNVAKVNDSWKERFLDV---ENELSRIRSEKASI------- 1914
Query: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAA---SEKESCIT----QLKKEL 1348
E++ ++AD+E + TEK L+K+ N+Q+ E+ S +T QL+ EL
Sbjct: 1915 -------EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 1349 ---SENINAVTLMKEELKEKKVEISSLS--------------KQLTDLNVQLQNSIS--- 1388
S+ A+ + E++KEK E+ S K+ T+L L + +S
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
Query: 1389 -----LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
L EK ++ + KCEL +Q+ L+ + + L KE S ++ + +
Sbjct: 2028 KDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
Query: 1444 EWKKKAQS----------RFTQHQNTVKELQIQLELKSKEAYEKDEQINL-LKEELDQQN 1492
K ++ R + Q V +L+ +E K + E DE+ L + E+L ++
Sbjct: 2088 NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLKERE 2146
Query: 1493 KRFDCLKGEMEDDKSKMEKKESNLET---ELKSQTARIMELEDHITQKT----------I 1539
+ D LK ++E+ + +++ E N E + ++ A + L+ I + +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKA 1599
+ S E L Q+K + EL + L F+ L EEK+ + +E+ T
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEM------ 2260
Query: 1600 ELETKKKELEHVNLSVKSKEEELKALEDRLES--ESAAKLAELKRKAEQKIAAIKKQLLS 1657
L+ + KEL ++ +E +KA E L+ E +L K ++ A +K+ L
Sbjct: 2261 -LQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLC 2319
Query: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILE--EKLKSVESSQSETLIVPRSAK-- 1713
+++ +E +E H L +++ ERE+ I ++ ++E+ S+ + AK
Sbjct: 2320 VLQQLKE-----SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE 2374
Query: 1714 ---------NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK---EE 1761
+ T + E ++ + +E+IS L+ + E +LQ QEK +E
Sbjct: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKE 2434
Query: 1762 TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG 1821
S+ EM Q +L +L A H DQ ++ L + + L AQ ++
Sbjct: 2435 KSSTAMEM---LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLD- 2490
Query: 1822 KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY 1881
+AK N + V +QE E Q LE+K +E+ S L Q + + E+L SK
Sbjct: 2491 ----EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI-SRLKNQIQ----DQEQLVSKL 2541
Query: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK------LLSNMEAQHNDLEFKLAGA 1935
+++ Q+ + + EL E + K ++Q K L +++ + +LE +L
Sbjct: 2542 SQVEGEHQL-WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 1936 EREKQKLGKEIVRLQ-KDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTL 1994
+ +K +++ ++ K+ + R+ H+ + + + + E+ + L L+ +
Sbjct: 2601 KMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
Query: 1995 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD--L 2052
K ++E + ++ ++ L+ K+ + K +V E+ E QL AEK L
Sbjct: 2661 KDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY------QLRLHEAEKKHQALL 2714
Query: 2053 KRTAKRYEEILDAREEEMTAKVRDLQTQ------------------------LEELQK-- 2086
T K+YE + E++T+K L +Q LEEL+K
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 2087 ----KYQQKLEQEENPGNDNVTIM-------------------ELQ-TQLAQKTTLISDS 2122
KY +L++E + ++ +LQ Q QKT + D+
Sbjct: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDT 2834
Query: 2123 KLKE--QEFREQIHNLEDRLKKYEK 2145
K+ E E +E LE++ K+ ++
Sbjct: 2835 KVDELTTEIKELKETLEEKTKEADE 2859
Score = 244 bits (623), Expect = 7e-64
Identities = 477/2351 (20%), Positives = 979/2351 (41%), Gaps = 321/2351 (13%)
Query: 17 QQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLF 76
QQ P+ SSNS R ++S+ E TP+R + LQ+ S F
Sbjct: 220 QQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRST---------LQIGKRDANSSF 270
Query: 77 --RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSL 134
S L + ++ +R E RL + + + + +
Sbjct: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI 330
Query: 135 NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELRE 194
KE+++ + R L +Y + T Y L+++ KKL ++D S +R
Sbjct: 331 EKEKVLNKCR---DELVRTTAQYDQASTKYTALEQKLKKL------TEDLSCQRQNAESA 381
Query: 195 ELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ 254
++Q+ K+ ++EF L + + L + +K RL + + Q E
Sbjct: 382 RCSLEQKIKEK-EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD 440
Query: 255 AEVFTK---EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
K E N E + + + + + + ++R +K+ ++SH EQ
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR 500
Query: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE-----QDKGMVI 366
EA + + + L + + + A+ T T LRD + I Q E + + +
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560
Query: 367 AETKRQ---MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL--EKALS 421
A+ ++Q + L+ +E I QL ++ + + + L E ++ +EEL EK L
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK-EYEELKEEKTLF 619
Query: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
+ K+E + + E +++ + E + QQ S E V ++ E ++
Sbjct: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
Query: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY----LKISQEKEQQESLAL 537
+ LH ++ + T+KL E Q++ + + +K Q E LK SQ Q E L
Sbjct: 680 RNLHNVLDSKSVEVETQKL--AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE- 736
Query: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
+L+L I+ + + +DL E E+ R +L S + SL N++ + L + + +
Sbjct: 737 HKLQLLSNEIM-DKDRCYQDLHAEYESLR----DLLKSKDASLVTNEDHQRSL-LAFDQQ 790
Query: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ------QYQTEMEK-----LR 646
H+ ++ E+ E + + +A + K + Q ++ E +K L+
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQ 850
Query: 647 EKCEQ------EKETLLKDKEIIFQAHIEEMNEK-----------------TLEKLDVKQ 683
++CE+ E E L E + Q+ + E +++ TL L+ K+
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 684 TELESLS-------SELSEVLKARHKLEE---ELSVLKDQTDKMKQELEA-------KMD 726
EL+ L+ +E+ E+ K+ H LE+ EL +L + K+E+ + +++
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970
Query: 727 E--QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ-------A 777
E Q+N +++++ + + ++++ + ++ + I++ E + E K+ +
Sbjct: 971 ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE 1030
Query: 778 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL------------- 824
N D+ + Q+ ++KL+ + ++ E K EQL +
Sbjct: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 825 ------QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Q +L+LET + L ++ + + K L + +++ +++K+ +++
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
Q+ + L +V ++K E N E E + + E+E+ Q + ++E+ L DS
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL----DSY 1206
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL------EL 992
+ + E +N+E K+++ +++ + +Q L+ D E +++++ + E+
Sbjct: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
Query: 993 SQKEKQFNA-KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
+EK + L +Q ++A + ++ + N+ ++E + E+ + E ++++ +L
Sbjct: 1267 DAEEKYISGPHELSTSQNDNAHLQCSL-QTTMNKLNELEKICEILQAEKYELVT----EL 1321
Query: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
N E ++ +EV +L ++ + + ++ E+ +D E
Sbjct: 1322 NDSRSEC----ITATRKMAEEVGKLLNEVKILNDDSGLLHGELV--------EDIPGGEF 1369
Query: 1112 QEQLKQKSAHVNSLAQ-DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
EQ ++ H SLA DE+ HL + ++ E LQE+ + L+ + +
Sbjct: 1370 GEQPNEQ--HPVSLAPLDESNSYEHLTLSDKEVQMHFAE---LQEKFLSLQSEHKILHDQ 1424
Query: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK-----LSEELAIQLDICCKKTE 1225
+++SK+ SLK+ + + +L + + K L E L L C
Sbjct: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDS 1484
Query: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
+ L + + SS A+L + + ++ A+ C+V E+ L EE
Sbjct: 1485 SSLSSLGD------SSFYRALLEQTGD-MSLLSNLEGAVSANQCSVDEVFCS--SLQEEN 1535
Query: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESL--VTEKEALQKEGGNQ---QQAASEKESC 1340
T + +EE E+ + + +E L E + + K Q Q +SE++
Sbjct: 1536 LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL 1595
Query: 1341 ITQLKKELSEN------INAVTL-MKEELKEKKVEISSLSKQLTDLNVQLQ------NSI 1387
K+ LSEN + +VTL M+ +L +K + LS +L +QLQ S+
Sbjct: 1596 DCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655
Query: 1388 SLSEKEAAIS------SLRKQYDEEKCELL-----------DQVQDLSFKVDTLSKEKIS 1430
+ E AI + K++ E E D QDL+ ++ ++ +
Sbjct: 1656 LGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT--ETG 1713
Query: 1431 ALEQVDDWSNKFS---EWKKKAQSRFTQHQNTVKELQI-------------------QLE 1468
A++ + S + S ++ + + + EL L+
Sbjct: 1714 AVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQ 1773
Query: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
L+ KE +E + LL ++ ++++ + L EM++ SK+ +E L T++++ +
Sbjct: 1774 LRVKET--SNENLRLL-HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA----CI 1826
Query: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEA----- 1583
ELE + + E L+E L+ ++ +H+EL+Q+++ + L + + ++
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFS----CDHQELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 1584 -----------EEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR---- 1628
+E+ L +EN++ +++E + + E ++ ++ + E LE
Sbjct: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942
Query: 1629 ------LESESAAKLAELKR-KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
LE E + +E + + E + K L Q+ EK ++ + ESH SE +
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
Q E EV E L+++ S SE L + ++ + E DSQ E + +
Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELL---KDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 1742 QRN------LTEKEKLLQRVGQEKEETVSSHFEMRCQYQER---LIKLEHAEAKQHEDQS 1792
Q N + E E L R+ + E ++ + E+ ++L + + H+ +
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
I L+ +E KK L +A+ + KE + N K +EN+ ++Q + + +EL
Sbjct: 2120 GIEKLRVRIEADEKK-QLHIAEKL-KERERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 1853 EQKIKELDSCLVRQKEVHR----VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
E E+++ + +E+ R E++ +T + EK +Q+ + K +L E + S
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI--QEKQGQLSELDKLLSS 2235
Query: 1909 KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
L++ K + ++ + + + + + + ++L + + L D ++ K +Q L+
Sbjct: 2236 FKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIM-KATEQSLDPPI 2293
Query: 1969 KEYDQERE--EKIKQEQEDLELKHNSTLKQLMRE------FNTQLAQKEQELEMTIKETI 2020
+E Q R EK++ E E K L+QL ++ E+ELE+
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
Query: 2021 NKAQEV-----EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVR 2075
+ A E E E L++ E Q L+ + E D R+ K +E+E +++
Sbjct: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGL-ELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 2076 DLQTQLEE-LQKKYQQKLEQEENPGNDNVTIME-LQTQLAQKTTLIS-------DSKLKE 2126
+ + E LQ+K Q+K++ +E + T ME LQTQL + ++ K KE
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEK----SSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
Query: 2127 QEFREQIHNLE 2137
Q Q+ LE
Sbjct: 2469 QNLSSQVECLE 2479
Score = 239 bits (610), Expect = 2e-62
Identities = 458/2267 (20%), Positives = 951/2267 (41%), Gaps = 370/2267 (16%)
Query: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117
+Q+FA++++ + S E++ R +E + + + +L +L L + A +
Sbjct: 519 SQNFAEEMKAKNTSQETMLRD----------LQEKINQQENSLTLEKLKL--AVADLEKQ 566
Query: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
D ++DL+ + + EQL +L + E+ + Y+ L +E+K L
Sbjct: 567 RDC---SQDLLKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEEL-KEEKTLFSC 621
Query: 178 LSQSQDKSLRRIAELREELQMD----------QQAKKHLQEEFDASLEEKDQYISVLQTQ 227
+K L ++ +E LQ QQ K H E +LE + +SV +
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV---E 678
Query: 228 VSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
+ L L + + V+ K +L+ +AE F+ +++ + ++ +E L+
Sbjct: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAE-FSDQKHQKEIENMCLKTSQLTGQVEDLEH 737
Query: 287 RVKRQENLLK---RCKETIQSHKEQCTLLTSEKEA---LQEQLDERLQELEKIKDLH--- 337
+++ N + RC + + + E L K+A E L ++ +H
Sbjct: 738 KLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 797
Query: 338 ---MAEKTKLITQLRDAKNLIEQLEQDKGMV---------IAETKRQMHETLEMKEEEIA 385
+ E+ + ++ + + +Q ++ ++ E+++QM+ L+ + EE+
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Q++ I++ + E++ + + E + +S Q+ A + + AE ++
Sbjct: 858 QIKGEIEENLMKAEQMHQ-------SFVAETSQRISKLQEDTSAHQNVVAETLSALE--- 907
Query: 446 KTSEEERISLQQELSRVKQEVVDVMKKSS---EEQIAKLQKLHEKELARKEQELTKKLQT 502
++E+ + L + +Q + +KKS+ E+ + +LQ L E L+ +++E++ +
Sbjct: 908 --NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSE-TLSLEKKEMSSIISL 964
Query: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
+RE +E + ++ LK QE + L + + E E + +L +
Sbjct: 965 NKREIEELTQ------ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
Query: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK------EITVMVEKHKTEL 616
+ + +L+ +E N +DL+ +A + K++K E T + E K EL
Sbjct: 1019 KQEKLILLQ-------RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL 1071
Query: 617 ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
E LK + +++Q + KL E+ + L+ + E + QA EM +
Sbjct: 1072 EQLK-----------EAFAKEHQEFLTKL-AFAEERNQNLMLELETVQQALRSEMTDNQ- 1118
Query: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
+ ++E L E+ + + ++K+++E++ L + +++ + ++ K E +N + +
Sbjct: 1119 ---NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPI 1174
Query: 737 DSIIKEHE-----------VSIQRTEKALKD---QINQLELLLKERDKHLKEHQAHVENL 782
+ +KE E + ++ E +L Q+ QLE +L+ ++ L+E + E L
Sbjct: 1175 RNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECL 1234
Query: 783 EADIKRSEGELQQAS--------------AKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
+ +++ G+L+ ++ ++D + Y S HE + + + A LQ L
Sbjct: 1235 QHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN-AHLQCSL 1293
Query: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ-- 886
+ L K ++A+K ++ TEL+ + + +++ ++ ++ +VK L
Sbjct: 1294 QTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353
Query: 887 --VYESKLED------GNKEQEQTKQILV------EKENMILQMREGQKKEIEILTQKLS 932
++ +ED G + EQ L E++ L +E Q E+ + LS
Sbjct: 1354 GLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLS 1413
Query: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE------ 986
+ + H + + + ++ +++ K L L + + L KE++
Sbjct: 1414 LQSE--HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEG 1471
Query: 987 -----------NTALELSQKEKQFNAKMLEM-------------AQANSAGISDA----- 1017
+++ S + F +LE AN + +
Sbjct: 1472 LVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSL 1531
Query: 1018 ----VSRLETNQK-----EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQE 1068
++R ET E++ESL EV+R+ L + E + + +E+QE+ ++ L
Sbjct: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL-LSS 1590
Query: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
+ QE+ L+++ L E E+ +++T TL E++ +L + L+ +
Sbjct: 1591 ERQELDCLRKQYL---SENEQWQQKLT---------SVTL-EMESKLAAEKKQTEQLSLE 1637
Query: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188
+ L+ L++ L +T ++ + + K SE T + D
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDT--EDAIQGRNESCDISKEHTSETTERTPKHD------ 1689
Query: 1189 KSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247
H+ +K + +D +L+ +K++E A++ C ++ KT
Sbjct: 1690 --VHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE----QSPDTNYEPPGEDKTQGSS 1743
Query: 1248 SRISHCQHR--TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ 1305
IS V L + L+ ++++ + E L H +E+++ +
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL-------LHVIEDRDRK 1796
Query: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE---LSENINAVTLMKEEL 1362
++S+ +++ L ++ + + + +A E E + +LKKE LSE + + +EL
Sbjct: 1797 VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL 1856
Query: 1363 KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVD 1422
+ +VE S LN L+ S +E ++ K D K LD +LS
Sbjct: 1857 LQ-RVETSE------GLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELS---- 1905
Query: 1423 TLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ-- 1480
+ EK S +H+ E +++ K EKD +
Sbjct: 1906 RIRSEKAS-----------------------IEHEALYLEADLEVVQTEKLCLEKDNENK 1942
Query: 1481 ---INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH---- 1533
I L+EEL + L+GE++ M KK + L+ + + ELE H
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELD----TMSKKTTALDQLSEKMKEKTQELESHQSEC 1998
Query: 1534 ---ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE--EKDNRVKEAEEKIL 1588
I E++ E+L+ + + EL++ H QE + EKD++ +
Sbjct: 1999 LHCIQVAEAEVKEKTELLQTLSS----DVSELLKDKTHLQEKLQSLEKDSQALSLTK--C 2052
Query: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEE----LKALEDRL--ESESAAKLAELKR 1642
LENQ+ + E E KE E + + + E KALE L + E A +L+ +
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQE 2112
Query: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE--- 1699
+ Q I+K L ++E E++ + H++E KL+ERERE L++K++++E
Sbjct: 2113 EVHQLRRGIEK-LRVRIEADEKK-----QLHIAE---KLKERERENDSLKDKVENLEREL 2163
Query: 1700 --SSQSETLIVPRSAKNVAAYTE--QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
S +++ L++ A+N A E + + + K +E + L+ +EKE L +++
Sbjct: 2164 QMSEENQELVI-LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR---SEKENLTKQI 2219
Query: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHAEAK-QHEDQSMIGHLQEELEEKNKKYSLIVA- 1813
QEK+ +S ++ ++ L + E AE + + E ++ + LQ +L+E N+ + +
Sbjct: 2220 -QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
Query: 1814 QHVEKEGGKN---NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Q + K ++ I+ + L N + ++ L+ E + Q++KE + H
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE---------H 2329
Query: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKL-LSNMEAQHNDLE 1929
++ L + E L+ ++ N+ LE E SK + K + M LE
Sbjct: 2330 HADL--LKGRVENLERELEIARTNQEHAALE---AENSKGEVETLKAKIEGMTQSLRGLE 2384
Query: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
+ EK+ L E LQK+ +E ELEI+ ++ +EK EQE +++K
Sbjct: 2385 LDVVTIRSEKENLTNE---LQKE-----QERISELEIINSSFENILQEK---EQEKVQMK 2433
Query: 1990 HNST-----LKQLMREFNTQLAQKEQELEMTIKETINKAQEVE------AELLESHQEET 2038
S+ L+ ++E N ++A + E + N + +VE A+LL+ E
Sbjct: 2434 EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
Query: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098
N + + + L + + ++ L+ ++EE++ +Q Q E+L K Q + +
Sbjct: 2494 NNYI-VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ-EQLVSKLSQVEGEHQLW 2551
Query: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH----NLEDRLK 2141
N+ + L +L QK ++ Q+ E + NLE+ L+
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Score = 209 bits (533), Expect = 2e-53
Identities = 430/2126 (20%), Positives = 880/2126 (41%), Gaps = 349/2126 (16%)
Query: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350
+E L R + IQ + Q L EK+ Q QLD L+K K EKT+ R+
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE 68
Query: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI----AQLRSRIKQMTTQGEELREQKE 406
+ L+E E + +TK+++ L++KE ++ QL S KQ+ +EL+ K
Sbjct: 69 NQRLMEICES-----LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 407 KSERA--AFEELEKALS-------------------TAQKTEEARRKLKAEMDEQIKTIE 445
+ ER+ A + + +L+ + K E+ + K E++E+ +
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 446 KTSEEERISLQQELSRVKQEVVDVMKK------------------SSEEQIAKLQKLHEK 487
+ + Q L + D+ + SS Q +++
Sbjct: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243
Query: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL--ALEELELQKK 545
EQE+T T + ++ + S S +L + Q K Q + L + ELEL+ +
Sbjct: 244 SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL-LDQLKAQNQELRNKINELELRLQ 302
Query: 546 AILTESE---NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
E + NK ++LQ + E + ++E E L N+ +D V A+ ++ +
Sbjct: 303 GHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL--------NKCRDELVRTTAQYDQAS 354
Query: 603 KEITVMVEKHKTELESLKHQQD------ALWTEKLQVLKQQYQTEMEK-------LREKC 649
+ T + +K K E L Q+ +K++ ++++Q E+ + L ++C
Sbjct: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
Query: 650 EQEKETL------LKDKEIIFQAHIEEMN------EKTLEKLDVKQTELESL--SSEL-- 693
Q K L K+ + QA ++++ E LE+ K E +S++
Sbjct: 415 IQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Query: 694 SEVLKARHKLEEELSVLKDQTDKMKQE---LEAKMDEQKN--HHQQQVDSIIKEHEVSIQ 748
+E+ ++ ++++E ++LK +++ +E LEA++ K + Q +K S +
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
Query: 749 RTEKALKDQINQLELLL-------------KERD---KHLKEHQAHVENLEADIKRSEGE 792
+ L+++INQ E L K+RD LK+ + H+E L + ++E E
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 793 LQQASAKLD--------------VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
+ + L+ +F ++S + E + LQ K+ LET L
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET--CLK 652
Query: 839 TKQVAEVEAQKKDVCTELDAH--KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
T+Q+ E ++ E+D +++++L L+ ++ E+E + + ++ +
Sbjct: 653 TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQ 712
Query: 897 KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 956
K Q++ + + ++ + Q+ + + K +++L+ ++ K+ L+ EYE+ + +
Sbjct: 713 KHQKEIENMCLKTSQLTGQVEDLEHK-LQLLSNEIMDKDRCYQDLHAEYESL-----RDL 766
Query: 957 EKVKQKAKEMQETLKKKLL--DQEAKLKKELENTALELSQKEKQFNAKMLEMAQA--NSA 1012
K K + E ++ LL DQ+ + N E + + LE Q+ NSA
Sbjct: 767 LKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSA 826
Query: 1013 GISDAVSRLE----------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIH 1062
+ + V LE ++ ++Q E L ++ +++ + + AE Q I
Sbjct: 827 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 886
Query: 1063 EIQ----------------LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
++Q L+ KE+E+ L K+ E +E+ K L E+ +K+
Sbjct: 887 KLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS-NHLLEDSLKELQ 945
Query: 1107 TLNELQEQLKQKSAHVNSLAQDE----TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
L+E K++ + + SL + E T+ L+++ LN +E L ++
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN---QEKMNLIQKSESFAN 1002
Query: 1163 LAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
+E ++ +SEL+ + K +E L E++ + ED S ++K E+ + +L+
Sbjct: 1003 YIDEREKSISELSDQYK---QEKLILLQRCEETGNAYEDLSQKYKAAQEKNS-KLECLLN 1058
Query: 1223 KTEALLEAKTNELINIS---SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
+ +L E + NEL + + + L++++ + R + L+++ TV +A
Sbjct: 1059 ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER----NQNLMLELETVQ--QALRS 1112
Query: 1280 QLTEEQNTLNI---SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS- 1335
++T+ QN +Q L+E++N+ M+ ++ L+ E E L K + + +
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQNK---MQKEVNDLLQENEQLMKVMKTKHECQNL 1169
Query: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN-SISLSEKEA 1394
E E +K+ SE + +L+ K++ + S + QL L L+N + L E E
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229
Query: 1395 AISSLRKQYDEEKCEL-LDQVQDL-SFKVDTLSKEKISALEQVDDWSNKFSEWKK---KA 1449
L+ + + +L +QD+ S ++ L +I A E+ ++ S +
Sbjct: 1230 EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHL 1289
Query: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Q N + EL+ E+ E YE ++N + E ++ G++ ++ +
Sbjct: 1290 QCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKIL 1349
Query: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569
L EL E Q + + L+E N + + KE+ HF
Sbjct: 1350 NDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE--SNSYEHLTLSDKEV---QMHF 1404
Query: 1570 QELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKS----------K 1618
EL E+ + ++E KIL ++ Q+ S +EL+T L+ NL + + K
Sbjct: 1405 AELQEKFLS--LQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK 1462
Query: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
E +L E + S S++ + + + ++ + LL Q G S LS L
Sbjct: 1463 EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQ---------TGDMSLLSNLE 1513
Query: 1679 TKLQEREREV-HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
+ + V + L+ ++ ET P AK V EE +S + + Y +
Sbjct: 1514 GAVSANQCSVDEVFCSSLQEENLTRKETPSAP--AKGV------EELES---LCEVYRQS 1562
Query: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFE----MRCQYQERLIKLEHAEAKQHEDQSM 1793
+ L+ + + + + QE E+ +SS + +R QY L E Q + S+
Sbjct: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY------LSENEQWQQKLTSV 1616
Query: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ----AKQNLENVFDDVQKTLQEKELTC 1849
++ +L + K+ + +E E + +Q + ++L + D + +Q + +C
Sbjct: 1617 TLEMESKLAAEKKQTEQL---SLELEVARLQLQGLDLSSRSLLGI--DTEDAIQGRNESC 1671
Query: 1850 QILEQKIKELDSCLVRQKEVHRV----EMEELTSKYEKL------QALQQMDGRNKPTEL 1899
I ++ E + +VH++ ++L EK+ + + G P
Sbjct: 1672 DISKEHTSETTE-RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
Query: 1900 LEENTEEKSK--------------SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL--- 1942
E E+K++ + LV L N E HN L+ ++ E +L
Sbjct: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN-LQLRVKETSNENLRLLHV 1789
Query: 1943 ----GKEIVRLQKDLRML-RKEHQQELEILKK-EYDQEREE---KIKQEQEDLELK---- 1989
+++ L +++ L K H QE++++ K E E E+ ++K+E DL K
Sbjct: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF 1849
Query: 1990 ---HNSTLKQL-------------------------MREFNTQLAQKEQELEMTIKETIN 2021
H L+++ + + N ++ ++E + +
Sbjct: 1850 SCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRS 1909
Query: 2022 KAQEVEAELLESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ-- 2078
+ +E E L + E Q K EKD++ K ++++ EEE++ +
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENK------QKVIVCLEEELSVVTSERNQL 1963
Query: 2079 -----------TQLEELQKKYQQKLEQEENPGNDNVTIMEL-QTQLAQKTTLISDSKLKE 2126
T L++L +K ++K ++ E+ ++ + +++ + ++ +KT L+
Sbjct: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV 2023
Query: 2127 QEFREQIHNLEDRLKKYEKNVYATTV 2152
E + +L+++L+ EK+ A ++
Sbjct: 2024 SELLKDKTHLQEKLQSLEKDSQALSL 2049
Score = 187 bits (475), Expect = 1e-46
Identities = 342/1589 (21%), Positives = 698/1589 (43%), Gaps = 228/1589 (14%)
Query: 9 ISEEQQQLQQALAPAQASSNSSTPTRMRSR-TSSFTEQLDEGTPNRESGDTQSFAQKLQL 67
+ E Q L++ L P+ +SS + + S SSF L E T GD L
Sbjct: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQT-----GD-----MSLLS 1510
Query: 68 RVPSVESLFRSPIKESLFRSSSKESLVR--TSSRESLNRLDLDSSTASFDPPSDMDSEAE 125
+ S + + E S +E+L R T S + +L+S + + E
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
Query: 126 DLVGNSDSLNKEQLIQRLRRMERSLSSYRGKY-SELVTAYQMLQREKKKLQGILSQSQDK 184
+ G + ++L Q L + L R +Y SE Q L +++ L+ + +
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQ 1630
Query: 185 SLRRIAEL---REELQ-MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL----- 235
+ + EL R +LQ +D ++ L + + +++ +++ + + S +R
Sbjct: 1631 TEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDV 1690
Query: 236 -------RNGPMNVDVLK--PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
+N+D+ K ++P E + E++P+++ EP ED T + E + +
Sbjct: 1691 HQICDKDAQQDLNLDIEKITETGAVKPTGEC-SGEQSPDTNYEPPGEDKTQGSS-ECISE 1748
Query: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKT--KL 344
N L L ++++ QL + E ++ LH+ E K+
Sbjct: 1749 LSFSGPNALV-----------PMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKV 1797
Query: 345 ITQLRDAKNLIEQLEQDKGMVIAETKR--QMHETLEMKEEEIAQLRSRIKQMTTQGEELR 402
+ L + K L +L + ++ + + ++ + + ++E + L +++ + +EL
Sbjct: 1798 ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1857
Query: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV 462
++ E SE +LE A + + ++ + + + + +E + ++ ELSR+
Sbjct: 1858 QRVETSE-GLNSDLEM---------HADKSSREDIGDNVAKVNDSWKERFLDVENELSRI 1907
Query: 463 KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY 522
+ E K S E + L+ + E+ + E+ +K + E ++++ V LE E
Sbjct: 1908 RSE-----KASIEHEALYLEA--DLEVVQTEKLCLEK----DNENKQKVIVCLE----EE 1952
Query: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
L + + Q L+ + +K L + K+++ QE E++++ L E ++E
Sbjct: 1953 LSVVTSERNQLRGELDTMS-KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE 2011
Query: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
+L L ++ ++ K+ T + EK L+SL+ AL K E+
Sbjct: 2012 KT----ELLQTLSSDVSELLKDKTHLQEK----LQSLEKDSQALSLTKC---------EL 2054
Query: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
E + +EKE L+K+ E + QA + E + EKL+V + LE+ E E
Sbjct: 2055 ENQIAQLNKEKELLVKESESL-QARLSESD---YEKLNVSKA-LEAALVEKGEFALRLSS 2109
Query: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
+EE+ L+ +K++ +EA DE+K H + +KE E R +LKD++ LE
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEA--DEKKQLH---IAEKLKERE----RENDSLKDKVENLE 2160
Query: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ----SYQSATHEQTKAYE 818
L+ +++ + EN +A+++ + ++++ + L VF+ + +S TK +
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 819 EQLAQLQQ--KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
E+ QL + KLL + +L K+ AE++ +++ K V+ L QL++ N
Sbjct: 2221 EKQGQLSELDKLLS-SFKSLLEEKEQAEIQIKEES--------KTAVEMLQNQLKELNEA 2271
Query: 877 M------EQKVKSLTQVYESKLEDGNKEQEQTKQILV------EKENMILQMREGQKKEI 924
+ ++ +K+ Q + +E+ ++ + +++ +K+ +LQ + +
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 925 EILTQKLSAKEDSIHIL--NEEYET-KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
++L ++ E + I N+E+ + +N + ++E +K K + M ++L+ LD +
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV-VTI 2390
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
+ E EN EL +++++ + LE+ ++ I + + KE+ + E+ + +L
Sbjct: 2391 RSEKENLTNELQKEQERISE--LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL- 2447
Query: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQ------EVAELKQKILLFGCEKEEMNKEIT 1095
K+LN++ L E + KEQ E EL++ LL G ++ + N +
Sbjct: 2448 -------KELNERVAALHNDQEA-CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVNSLA---QDETKLKAHLEKLEVDLNKSLKENTF 1152
G+ Q+ + + +++L++K ++ L QD+ +L + L ++E E+
Sbjct: 2500 QSSVNGLIQE--VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE-------GEHQL 2550
Query: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
+EQ +EL+ L E ++K+ L SK + + + L+SS++ LE ++ E+
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
Query: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
+ + K+TE L+ + +E+ + KT + +S ++R + LL + +
Sbjct: 2611 VN---KMTAKETE--LQREMHEM----AQKTAELQEELSGEKNRLAGELQLLLEE---IK 2658
Query: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGG 1328
+ QL++LT E + L S EKE +++ A+ + + E E AL +
Sbjct: 2659 SSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Query: 1329 NQ--------QQAASEKESCITQLK----------KELSENINAVTLMKEELKEKKVEIS 1370
Q ++ + KE C++ K +EL+ ++ A T + EELK+ K++
Sbjct: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL 2778
Query: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKIS 1430
QL N + Q + L K KQ +EEK + L KE +S
Sbjct: 2779 KYVNQLKKENERAQGKMKLLIKSC------KQLEEEK--------------EILQKE-LS 2817
Query: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE-KDEQINLL--KEE 1487
L+ + + K T+ +KEL+ LE K+KEA E D+ +LL E+
Sbjct: 2818 QLQAAQEKQKTGTVMDTKVDELTTE----IKELKETLEEKTKEADEYLDKYCSLLISHEK 2873
Query: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
L++ + + + +SK + + S L
Sbjct: 2874 LEKAKEMLETQVAHLCSQQSKQDSRGSPL 2902
Score = 179 bits (454), Expect = 3e-44
Identities = 298/1373 (21%), Positives = 578/1373 (42%), Gaps = 189/1373 (13%)
Query: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959
E+ K+ L + +Q EGQ +++ Q+ + DS+ ++ + K +N++ + +
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDA 1017
K++ + + E + + L + K+ EL+ +++ +E Q N+ K +E + +
Sbjct: 66 KRENQRLME-ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE---LKRC 121
Query: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKL-------NQQAEELQEIHEIQLQEK- 1069
S LE +Q Q +V N I+ L + E+L+E + +++E+
Sbjct: 122 KSELERSQ--QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 1070 --EQEVAELKQKILLFGCEKEEMNKE-----------ITWLKEEGVKQDTTLNELQEQLK 1116
E EV L+ K + MN +W +E+ ++ ++ +
Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
Query: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
SA S Q+ T ++ L+ + D N S +N+ L +LK +E + K++EL
Sbjct: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
Query: 1177 KLKTTDEE-------FQSLKSSHEKSNKSLEDKSLEFKKLSEEL---AIQLDICCKKTEA 1226
+L+ ++E FQ L+ EK+ L +K K +EL Q D K A
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL-TEEQ 1285
L + ++S + NA +R S Q K KE EL Q R T +Q
Sbjct: 360 LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE-------FQEELSRQQRSFQTLDQ 412
Query: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI---- 1341
+ + + T +L++ +N ++A+++ L + K+ L+ +Q E
Sbjct: 413 ECIQMK-ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 1342 ---TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
+L++ + E L+K ++K E+ L +L ++ L S + +E+ A ++
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS----NKFSEWKKKAQSRFT 1454
++ + E ++Q Q+ S ++ L K ++ LE+ D S K ++ + +
Sbjct: 532 SQETMLRDLQEKINQ-QENSLTLEKL-KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE-------MEDDKS 1507
+ + K L LELK KE EEL ++ F C K E ME +K
Sbjct: 590 KTEKESKALLSALELKKKE-----------YEELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL-VQKL 1566
++ K ++LET LK+Q + E + + ++ E+L+ ++N + D + E+ QKL
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Query: 1567 QHFQ-----ELGEEKDNR---------------VKEAEEKILTLENQVYSMKAELETKKK 1606
+ + E ++K + V++ E K+ L N++ +
Sbjct: 699 AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
Query: 1607 ELEHVNLSVKSKEEELKALEDRLESESA----------------------AKLAELKRKA 1644
E E + +KSK+ L ED S A ++ +E + +A
Sbjct: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
Query: 1645 EQ--KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS--VES 1700
+Q K +AI + + +E E K ++N+ LQ++ E+ ++ +++ +++
Sbjct: 819 DQSPKNSAILQNRVDSLEFSLESQK--------QMNSDLQKQCEELVQIKGEIEENLMKA 870
Query: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK- 1759
Q V +++ ++ E A Q E +S L+ E + L +V E+
Sbjct: 871 EQMHQSFVAETSQRISKLQEDTSAH-----QNVVAETLSALENKEKELQLLNDKVETEQA 925
Query: 1760 --EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817
+E S+ + +E + E ++ E S+I + E+EE ++ + +
Sbjct: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985
Query: 1818 KEGGKNN-IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
K N IQ ++ N D+ +K++ EL+ Q ++K+ L C E E+
Sbjct: 986 LNQEKMNLIQKSESFANYIDEREKSI--SELSDQYKQEKLILLQRC-----EETGNAYED 1038
Query: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTE--EKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
L+ KY+ Q + +K LL E T E K+ L Q L +H + KLA
Sbjct: 1039 LSQKYKAAQ-----EKNSKLECLLNECTSLCENRKNELEQ--LKEAFAKEHQEFLTKLAF 1091
Query: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQ----QELEILKKEYD--QEREEKIKQEQEDLEL 1988
AE Q L E+ +Q+ LR ++Q E LK+E +E + K+++E DL L
Sbjct: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL-L 1150
Query: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ----------EVEAELLESHQEET 2038
+ N L ++M+ + + + + ++KE ++ EV+ L+S+ +
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
Query: 2039 NQLLKKIAEKDDDLKRTAKRYE----EILDAREEEMTAKVRDLQTQ--------LEELQK 2086
QL + K+ L+ + K E E+ R + T+ ++D+Q+Q + ++
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 2087 KYQQKLEQEENPGNDNVTIM-ELQTQLAQKTTLISDSKLKEQEFREQIHNLED 2138
KY + NDN + LQT + + L ++ + E E + L D
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND 1323
Score = 168 bits (426), Expect = 5e-41
Identities = 307/1461 (21%), Positives = 596/1461 (40%), Gaps = 227/1461 (15%)
Query: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ---QVDSI-----IKEHEVSIQRTEKAL 754
LEE L + + QELE ++D+ K QQ Q+DS+ ++ +V ++TE
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 755 KDQINQL-----------------ELLLKERDKHLKEHQAH-----VENLEADIKRSEGE 792
+ NQ EL +KE + +E Q + +E LE ++KR + E
Sbjct: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 793 L---QQASAKLDV------------------FQSYQSATHEQTK-AYEEQLAQLQQKLLD 830
L QQA+ DV Q Y + +E K Y +++ ++K L+
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE--ERKRLE 182
Query: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK--SLTQVY 888
E + L K+ ++ Q ++ H+ Q EK S + + + + +
Sbjct: 183 AEV-KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 889 ESKLEDGNKEQEQTKQIL-VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
+ G +E ++ L + K + + L +L A+ + E E
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSS--PHLLDQLKAQNQELRNKINELEL 299
Query: 948 KFKNQEKKMEKVKQKAKEMQ---ETLKKKLLDQEAKLKK---ELENTALELSQKEKQFNA 1001
+ + EK+M+ K +E+Q E K +L+++E L K EL T + Q ++ A
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
Query: 1002 ---KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
K+ ++ + S Q++ ES +++ + ++++L++Q
Sbjct: 360 LEQKLKKLTEDLSC------------QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
Q + + +Q K + EL+Q + + E++K +T +K++ + L E +++L +
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNVLQAELDK-LTSVKQQ---LENNLEEFKQKLCRA 463
Query: 1119 SAHVNSLAQDETKLKAHLEKLEVDLN-------KSLKENTFLQEQLVELKMLAEEDKRKV 1171
+ E +L+ +E+++ + N + +E L+ +L +K + +
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLS-EELAIQLDI---CCKKTEAL 1227
E+ K K T +E L+ EK N+ +LE KL+ +L Q D KK E
Sbjct: 524 EEM--KAKNTSQE-TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHH 580
Query: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
+E + N+ ++ + ++ A+LS + + ++KE + +C SE E L Q+ E+
Sbjct: 581 IE-QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKEN 639
Query: 1288 LNISFQQATHQLEE--KENQIKSMKAD--IESLVTEKEALQKEGGNQQQAASEKESCITQ 1343
L Q + LE K QIKS + + + +L ++E L E N K
Sbjct: 640 L----QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSK------ 689
Query: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403
S + L EL ++K E S Q N+ L+ S
Sbjct: 690 -----SVEVETQKLAYMEL-QQKAEFSDQKHQKEIENMCLKTS----------------- 726
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT------QHQ 1457
+L QV+DL K+ LS E + D ++ + +S+ HQ
Sbjct: 727 -----QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQ 781
Query: 1458 NTVKELQIQLELKSKEAYEKDEQINLLKE------ELDQQNKRFDCLKGEMEDDKSKMEK 1511
++ Q + A EQ ++ E E DQ K L+ ++ + +E
Sbjct: 782 RSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE- 840
Query: 1512 KESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE 1571
+ + ++L+ Q +++++ I + ++ E +++ E Q++ QE
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV----------AETSQRISKLQE 890
Query: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
N V E + E ++ + ++ET++ E++ + S E+ LK L+ L S
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ--LLS 948
Query: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
E+ + L++K I ++ K+ + ++ ++ K+ S E +Q+ E + +
Sbjct: 949 ETLS----LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
Query: 1692 EEKLKSV-----ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
+E+ KS+ + Q + +++ R + AY + + K +EK S L+ L
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK------YKAAQEKNSKLECLLN 1058
Query: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK-- 1804
E L + E E+ + + ++QE L KL AE + + +Q+ L +
Sbjct: 1059 ECTSLCENRKNELEQLKEAFAK---EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 1805 -NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
N+ S A +++E + K+ + +V LQE E ++++ K C
Sbjct: 1116 DNQNNSKSEAGGLKQE----IMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK----HECQ 1167
Query: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA 1923
+ E R ++E S+ + QMD K L N + L +EA
Sbjct: 1168 NLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQ------------LVQLEA 1215
Query: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL-KKEYDQEREEKIKQE 1982
+ E KL +E+EK+ L E+ ++ DL + Q EI K+ + + EEK
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275
Query: 1983 QEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042
+L N L+ +++ T+NK E+E ++ E Q E +L+
Sbjct: 1276 PHELSTSQND----------------NAHLQCSLQTTMNKLNELE-KICEILQAEKYELV 1318
Query: 2043 KKIAE-KDDDLKRTAKRYEEI 2062
++ + + + + T K EE+
Sbjct: 1319 TELNDSRSECITATRKMAEEV 1339
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 274 bits (701), Expect = 6e-73
Identities = 382/1812 (21%), Positives = 816/1812 (45%), Gaps = 182/1812 (10%)
Query: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL-EKIKDLHMAE 340
E QQR +RQ+ + + +E +E T+L E+E LQE+ +R +EL E+ + L E
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRE--TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 341 KTKLITQLRDAKNLIEQLEQDKGM---VIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ 397
+ +L + ++ + ++L +++ + E + Q E E +E Q R +Q+ +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 398 GEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 457
EE REQ+ + E+ EE + ++ EE RR+ + ++Q++ ++ E+++ +Q
Sbjct: 343 QEERREQQLRREQ---EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 458 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEK 517
+L R +Q E+Q+ + Q+L ++ R+EQE + Q E+E +EQ ++
Sbjct: 400 QLRREQQ-------LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 518 SQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE 577
+ ++LK +E E+ E +E Q+ E E + R L+ E E R + E L
Sbjct: 453 ERRDWLKREEETERHE----QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 578 KSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
+ +E + Q + K +E + ++ ++E + + Q++ + Q+LK++
Sbjct: 509 REQEERREQ-----------RLKRQEEEERLQQRLRSEQQLRREQEE----RREQLLKRE 553
Query: 638 YQTEME------KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
+ +E +L+ + E+ ++ LLK +E Q ++ E+ LE+ +K+ E+E L
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR-LKREEVERLEQ 612
Query: 692 ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
E E + R K EE + Q K +++ E + + + Q++ + +K E +R E
Sbjct: 613 E--ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERLE 669
Query: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
+ LK +E ++ +E + E E +R + + + +L+ A
Sbjct: 670 QRLK----------REHEEERREQELAEEEQEQARERIKSRIPKWQWQLE-----SEADA 714
Query: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Q+K Y Q Q+ + E+ ++ E E Q ++ E AH+ QQ E
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEK----RRRRESELQWQE---EERAHR------QQQEE 761
Query: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
+Q + + ++ E K E G +++ + L E+ L+ E Q++E L ++
Sbjct: 762 EQRRDFTWQWQA-----EEKSERG-RQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
++ E E +F +E+++++ +++A+++QE +E L+++ E +
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQR-RERAQQLQE--------EEDGLQEDQERRRSQ 866
Query: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI---ESLTEVHRRELNDVISIWE 1048
++++++ ++ E + + + E +KEQ E E+ R E
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE--------R 918
Query: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
+K +Q +E Q E QLQ++E+++ +EE K +E ++D L
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLL------------REEREKRRRQERERQYRKDKKL 966
Query: 1109 NELQEQLKQKSAHVNSLAQDETKLKAH--LEKLEVDLNKSLKENTFLQE---QLVELKML 1163
+ +EQL + + E K + L++ E L + +E QE Q + L
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223
+E+++ + E K + + E Q E+ E++ L ++ +L+ +K
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQY----REEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 1224 TEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTE 1283
E L + + L + R + + +E LL + E E + RQ E
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE-----EREKRRRQELE 1137
Query: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ 1343
Q QQ QL +E + K + ++E E+E LQ+E +Q E+E +
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPE-KRRRQELERQYREEEELQQE--EEQLLREEQEKRRQE 1194
Query: 1344 LKKELSENINAVTLMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
+++ E +EEL ++K+ + Q +DL Q + EKE A+ +
Sbjct: 1195 RERQYRE--------EEELQRQKRKQRYRDEDQRSDLKWQWE-----PEKENAVRDNKVY 1241
Query: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISAL---EQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
+ E Q++D + D S++ + L +Q D + W+++ + F + +
Sbjct: 1242 CKGRENEQFRQLEDSQLR-DRQSQQDLQHLLGEQQERDREQERRRWQQRDR-HFPEEEQL 1299
Query: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
+E Q + + + +++ E+ + LL+EE +++ +R + + E+++ E++E L +
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQ---LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
+ + R EL H Q +E + + ++K ++ ++ ++ + Q+L +++D +
Sbjct: 1357 ERDRKFREEELR-HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
+E E+++ E + E + +++E E L +E++L+ R E L E
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLE---EEQQLRQERHRKFREEEQLLQE 1472
Query: 1640 LKRKAEQKIAAIKKQLLSQME-EKEEQYKKGTESHL--SELNTKLQEREREVHILEEKLK 1696
+ + + +K L + + ++E+ +K E L E K E E+++H + + K
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL-QRV 1755
++ Q L + +++ + + Q+ E+++S +R+ K +L Q+V
Sbjct: 1533 FLQEEQQ--LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD--RKFRLEEQKV 1588
Query: 1756 GQEKEETVSSHFEMRCQYQERLIKL-EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814
++++E E + + QE +L + + K ED+ ++ +E+ + ++ + +
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 1815 HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE---LTCQILEQKIKELDSCLVRQKEVHR 1871
+ + Q + + + F + ++ LQE E L Q ++K +E + L RQ+ +
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 1872 VEMEELTSKYEKLQA-LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH---ND 1927
EE + ++L+ ++ + + TE + +E+ + L + +L E Q +
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768
Query: 1928 LEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY-DQEREEKIKQEQEDL 1986
+ K E+ +Q+ ++ +R Q+ R R+E Q E +++ Q+R+ K + E+E L
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828
Query: 1987 ELKHNSTLKQLMR--------EFNTQLAQKEQELEMTIKETINKAQEVEAELLESH---Q 2035
+L+ + R +F TQ + +E E+ +E + QE E +L E H Q
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 2036 EETNQLLKKIAE 2047
++ Q +++ E
Sbjct: 1889 QKEEQRHRQVGE 1900
Score = 272 bits (695), Expect = 3e-72
Identities = 420/1924 (21%), Positives = 850/1924 (44%), Gaps = 280/1924 (14%)
Query: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKL 344
++R KRQE + + QS K++ L +++ E+L + QE ++ ++ E
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQE-RLEQRDRQRRDEELWRQRQEWQEREERRAEE---- 190
Query: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR-IKQMTTQGEELRE 403
EQL+ KG HET E +EE QLR R + ++ +G E ++
Sbjct: 191 -----------EQLQSCKG----------HETEEFPDEE--QLRRRELLELRRKGREEKQ 227
Query: 404 Q--KEKSERAAFEELEKAL---STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
Q +E+ +R EE EK T + EE KL+ E ++ + +++ E+ R +QE
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEE--EKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQE--------- 509
L R +QE E+Q +L++ E++L RK++E ++ Q RE QE
Sbjct: 286 LRRERQE--------EEQQQQRLRR--EQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 510 --QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR---------DL 558
Q++ E+ + + L+ QE+E++E E E +++ E +LR L
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH------ 612
++E + R + L E L + Q + Q E + KH +E K
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 613 ---KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 669
K E E+ +H+Q+ K Q+ + Q + E+ + E+E+ + +E + E
Sbjct: 456 DWLKREEETERHEQE---RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 670 EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
E E+ L+ +Q E E L L + R + EE L + ++ + E E + K
Sbjct: 513 ERREQRLK----RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Query: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 789
+++ D ++K E +R ++ ++Q +LE LK + E + E E +KR
Sbjct: 569 REQEERRDQLLKREEE--RRQQRLKREQEERLEQRLKREEVERLEQE---ERREQRLKRE 623
Query: 790 EGE----------LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT 839
E E +Q + + Q EQ EE+ +L+Q+ L E E
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR-LKREHEEERRE 682
Query: 840 KQVAEVEAQKK-------------DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
+++AE E ++ + +E DA + +V ++ E Q EQ+ K +
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
ES+L+ +E+ +Q E+ + ++K E Q+LSA+ L E+ E
Sbjct: 743 --ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS-ERGRQRLSARPP----LREQRE 795
Query: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
+ + +E++ + + +E ++ +Q + ++E E L ++E+ + +
Sbjct: 796 RQLRAEERQQREQRFLPEEEEK-------EQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 1007 AQANSAGISDAVSRLETNQKEQIE----SLTEVHRRELNDVIS--IWEKKLNQQAEELQE 1060
Q G+ + R + ++ + + L E +R + + + +++L ++ + LQE
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ----EQLK 1116
E +LQ +E+E +++ + E++ +E L+EE K+ E Q ++L+
Sbjct: 909 -EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
QK L +E + + E+ K +E LQ++ +L + E +KR+ E
Sbjct: 968 QKE---EQLLGEEPEKRRRQER-----EKKYREEEELQQEEEQL-LREEREKRRRQEWER 1018
Query: 1177 KLKTTD----EEFQSLKSSHEKSNKSLEDKSLEFKK-----------LSEELAI----QL 1217
+ + D EE Q L+ EK + L+++ ++++ L EE +L
Sbjct: 1019 QYRKKDELQQEEEQLLREEREK--RRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277
+ +K E L + + L + R + + +E LL + E E +
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE-----EREKR 1131
Query: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
RQ E Q QQ QL +E + K + ++E E+E LQ+E +Q E+
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPE-KRRRQELERQYREEEELQQE--EEQLLREEQ 1188
Query: 1338 ESCITQLKKELSENINAVTLMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
E + +++ E +EEL ++K+ + Q +DL Q + EKE A+
Sbjct: 1189 EKRRQERERQYRE--------EEELQRQKRKQRYRDEDQRSDLKWQWE-----PEKENAV 1235
Query: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL---EQVDDWSNKFSEWKKKAQSRF 1453
+ + E Q++D + D S++ + L +Q D + W+++ F
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLR-DRQSQQDLQHLLGEQQERDREQERRRWQQR-DRHF 1293
Query: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE 1513
+ + +E Q + + + +++ E+ + LL+EE +++ +R + + E+++ E++E
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQ---LLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 1514 SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
L + + + R EL H Q +E + + ++K ++ ++ ++ + Q+L
Sbjct: 1351 QPLRRQERDRKFREEELR-HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES 1633
+++D + +E E+++ + E + K +E E V+ +E E K LE+
Sbjct: 1410 QDRDRKFREEEQQL---------SRQERDRKFREEEQ---QVRRQERERKFLEEE----- 1452
Query: 1634 AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEE 1693
+L+++ +K ++QLL + EE++ ++ L E +L+ +ER+ E+
Sbjct: 1453 ----QQLRQERHRKFRE-EEQLLQEREEQQLHRQERDRKFLEE-EQQLRRQERDRKFREQ 1506
Query: 1694 KLKSVESSQ---SETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
+L+S E + E + R + E+++ Q Q+ +++ R E+E+
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR----DRKFREEEQ 1562
Query: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
L QE+EE ++ Q ++R +LE + ++ E + +++E
Sbjct: 1563 L----RQEREEQ-----QLSRQERDRKFRLEEQKVRRQEQERKF--MEDE---------- 1601
Query: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE---LTCQILEQKIKELDSCLVRQK 1867
Q + ++ G+ Q +Q + F + ++ LQE+E L Q ++K E + L RQ+
Sbjct: 1602 ---QQLRRQEGQQ--QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 1868 EVHRV---------EMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL 1918
++ E E+L + E+ Q +Q R E + +E+ + L + + L
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ-----QELEILKKEYDQ 1973
E LE K E+ +Q+ +E +R Q+ R + +E Q +E ++ ++E D+
Sbjct: 1717 RRQE-----LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771
Query: 1974 E--REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031
+ EE+++QE+E+ +L+ + ++ E + ++EQ+L ++ + +E + +L
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831
Query: 2032 ESHQEETNQLLKKI-AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
E Q + ++ AE+ + ++R E+ L EE+ + R+ + + E +++ QQ
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR--QQ 1889
Query: 2091 KLEQ 2094
K EQ
Sbjct: 1890 KEEQ 1893
Score = 232 bits (592), Expect = 3e-60
Identities = 362/1800 (20%), Positives = 776/1800 (43%), Gaps = 195/1800 (10%)
Query: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRT-SSFTEQLDEGTPNRESGDTQSFA 62
+L++K EE+QQ ++ R R E+L E P R+ +
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR---ELQE 273
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
++ QLR + L R +E + + +E R + + +
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQ 182
E + +EQ ++R + ER R + E Q+ + ++ + + L + Q
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 183 ----DKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL- 235
++ LRR +LR E Q+ +QQ ++ Q + E +Q + + +QRL
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ-----KHEQERREQRLK 448
Query: 236 RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL 295
R D LK + E + K++ E E ++ E +Q+ +R++ L
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 296 KRCKETIQSHKEQCTLLTSEKEALQEQLDE----RLQELEKIKDLHMAEKTKLITQLRDA 351
+ +E +EQ E+E LQ++L R ++ E+ + L E+ K + Q R
Sbjct: 509 REQEE----RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE 564
Query: 352 KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT-QGEELREQKEKSER 410
+ L + E+ + ++ + + + L+ ++EE + R + +++ + EE REQ+ K E
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470
E ++ L + ++ E +++L+ E E+ E+R+ ++E R++Q +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQER--------REQRLKREEEEERLEQR----L 672
Query: 471 KKSSEEQIAKLQKLHEKELARKEQELTK-KLQTREREFQEQMKVALEKSQSE-YLKISQE 528
K+ EE+ E+ELA +EQE + ++++R ++Q Q++ + QS+ Y + ++
Sbjct: 673 KREHEEE------RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQ 726
Query: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS- 587
+ Q+ EE ++++ L E + QQ+ E R + EKS + + S
Sbjct: 727 EGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 588 -----KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
+ L AE+ + ++ + E+ K + + +++ ++LQ L+++ Q +
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE----KELQFLEEEEQLQR 842
Query: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK-QTELESLSSELSEVLKARH 701
+ ++ ++E++ L +D +E ++ D K + +LE L A+
Sbjct: 843 RERAQQLQEEEDGLQED---------QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
L+E+L K+Q ++E E + +E++ +Q+ + +E E Q E+ L+++ +
Sbjct: 894 ALQEQLR--KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 762 ELLLKER----DKHLKEHQAHVENLEADIKR---------SEGELQQASAKLDVFQSYQS 808
+ER DK L++ + + E + +R E ELQQ +L + +
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 809 ATHEQTKAY--EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866
E + Y +++L Q +++LL E E+ +++ E E Q ++ ++
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREK----RRLQERERQYRE------------EEE 1055
Query: 867 MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926
+QQ E+Q E++ + ++ ++ +QE+ + + E E Q RE Q +E E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 927 LTQKLSA--KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
L Q+ +E+ +E E +++ +E+ ++ +Q +E E +++ L+++ + ++E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 985 LENTALEL---------SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
L+ +L ++E+Q+ + Q D R + + + E V
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 1036 HR-------RELNDVISIWEKKLN--QQAEELQEI-HEIQLQEKEQEVAELKQKILLFGC 1085
RE + + +L Q ++LQ + E Q +++EQE +Q+ F
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 1086 EKE---EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142
E++ E KE + ++ L E +E+ +++ ++E L+ E+ E
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ---EREEQP 1352
Query: 1143 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH-----EKSNK 1197
L + ++ F +E+L +E RK E +L+ + E + LK E+ +
Sbjct: 1353 LRRQERDRKFREEELRH-----QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 1198 SLEDKSLEFKKLSEELAIQ-LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256
+D+ +F++ ++L+ Q D ++ E + + E + + ++ +HR
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ------QLRQERHR 1461
Query: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
+ +E LL E + +QL ++ + F + QL +E K + ++ S
Sbjct: 1462 KFREEEQLL--------QEREEQQLHRQER--DRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 1317 VTEKEALQKEGG-----NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISS 1371
E++ L++E Q++ E++ Q + + +EE ++ E
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 1372 LSKQLTDLNVQLQNS-ISLSEKEAAI----SSLRKQYDEEKCELLDQVQDLSFKVDT-LS 1425
LS+Q D +L+ + E+E LR+Q +++ L Q +D F+ D L
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ---LRQERDRKFREDEQLL 1628
Query: 1426 KEKISALEQVDDWSNKFSE-------WKKKAQSRFTQHQNTVKELQIQLELKSKEA--YE 1476
+E+ + KF E +++ Q R + + +E Q+ E + ++ E
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Query: 1477 KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
+D + +++L +Q + L+ E + + ++E+K E +L+ +T + +
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE-EEQLRQETEQEQLRRQERYR 1747
Query: 1537 KTIEIESLN------EVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
K +E E L ++ + +K E ++L Q+ + Q +E D + +E E+ L
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ--LRQ 1805
Query: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR-LESESAAKLAELKRKAEQKIA 1649
E + ++ + K E L ++ +E+ L+ DR +E E R+ EQ++
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL- 1864
Query: 1650 AIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVP 1709
+E+E++ ++ E L E + + Q++E + H ++KS E L+ P
Sbjct: 1865 ---------WQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 208 bits (530), Expect = 4e-53
Identities = 335/1762 (19%), Positives = 781/1762 (44%), Gaps = 194/1762 (11%)
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L++ H+ + EL +F E + + +Q+ Y + Q + L+
Sbjct: 43 AVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQ------ATGLD 96
Query: 539 ELELQKKAILTESENKLRDLQQEAETY----RTRILELESSLEKSLQENKNQSKDLAVHL 594
E +K+A E+ L+D +QE + R R LE E ++ Q+ + Q ++LA
Sbjct: 97 E---EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPG-QRRRQKRQEQERELA--- 149
Query: 595 EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT-------------- 640
E E+ +E ++ + + E + +Q+ E+ + ++Q Q+
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 641 ----EMEKLREKCEQEKETLLKDK-EIIFQAH-----------IEEMNEKTLEKLDVKQT 684
E+ +LR K +EK+ +++ + +FQ + + EK E+ +Q
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
EL+ +L ++ + + E + + Q + +Q+L K +E++ Q++ + E
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 745 VSIQRTEKALK--DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802
+R E+ L+ + + + L +E+++ +E Q E E + + + +Q +
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ-EEERREQQLRREQQLRREQQ 388
Query: 803 FQSYQSATHEQTKAYEEQLAQLQQ--KLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
+ Q EQ E+QL + QQ + L E+ L +Q E QK + +
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE-------QE 441
Query: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ---ILVEKENMILQMR 917
+ Q L ++ E++ ++++ ++ E + + ++QE+ ++ + +E+E + R
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE----ERR 497
Query: 918 EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
E Q++ + L ++ + + + +E E + + + + ++++++ +E +E L K+ ++
Sbjct: 498 EQQERREQQLRREQEERREQ-RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR--EE 554
Query: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN-QKEQIESLTEVH 1036
E +L++E L+ Q+E++ E + + RLE ++E++E L +
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
RRE E++ QQ + +E E + Q+ +E E +++ L E+E + + +
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
EE ++ E QEQ +++ + K + LE E D +S K + ++Q
Sbjct: 675 EHEEERREQELAEEEQEQARER------IKSRIPKWQWQLES-EADARQS-KVYSRPRKQ 726
Query: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
+ + +E+KR+ E S+L+ +EE +H + + + + ++ +EE + +
Sbjct: 727 EGQRRRQEQEEKRRRRE--SELQWQEEE-----RAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 1217 LDICCKKTEALLEAKTNEL-INISSSKTNAIL----SRISHCQHRTTKVKEALLIKTCTV 1271
L E + +L + L + + R + KE ++
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKEN----QIKSMKADIESLVTEKEALQKEG 1327
+ + +QL EE++ L ++ Q + ++ Q++ + + K ALQ++
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSL-----SKQLTDLNVQ 1382
+QQ E+E + + ++E +EE + ++ E L ++ + Q
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
+ L +KE + EE + Q ++ ++ + +++ L + + +
Sbjct: 960 YRKDKKLQQKEEQL------LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
EW+++ + + Q +E Q+ E + K ++ E+ +EEL Q+ ++ L GE
Sbjct: 1014 QEWERQYRKKDELQQ---EEEQLLREEREKRRLQERERQYREEEELQQEEEQ---LLGEE 1067
Query: 1503 EDDKSKME-KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
+ + + E +++ E EL+ + +++ E E + +++ +E
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEP-------------EKRRRQERERQCREEE 1114
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL---ETKKKELEHVNLSVKSK 1618
+Q+ + Q L EE++ R ++ E+ E +V + +L E +K+ + + + +
Sbjct: 1115 ELQQ-EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR-E 1172
Query: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ-----YKKGTESH 1673
EEEL+ E++L E K + + + ++ +++Q Q E+Q ++ E
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
+ + K+ + RE E+ + +E SQ + +++ EQ+E D + ++
Sbjct: 1233 NAVRDNKVYCKGRE----NEQFRQLEDSQLRDRQSQQDLQHLLG--EQQERDREQ-ERRR 1285
Query: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
++++ R+ E+E+L + +E+ + + + Q +++L++ E E ++ ++
Sbjct: 1286 WQQR----DRHFPEEEQL-----EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 1794 IGHLQEEL-----------EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842
+E+L +E+++K+ +H +E G+ ++ +Q L + +
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRH--QEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEE 1902
+E++L CQ EQ++++ R++E ++ +E K+ + + QQ+ + + + LEE
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEE-QQLSRQERDRKFREEE--QQVRRQERERKFLEE 1451
Query: 1903 NTEEKSKSH--------LVQPKLLSNMEAQHNDLEF-----KLAGAEREKQKLGKEIVRL 1949
+ + + H L+Q + + Q D +F +L ER+++ +E+
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 1950 QKDLRMLRKE-----HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ 2004
+ + + L +E Q++ + L++E R+E+ +Q ++D + K + Q
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064
L+++E++ + ++E + QE E + +E Q+ Q ++ ++ D R + E++L
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD--RKFREDEQLLQ 1629
Query: 2065 AREE-EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSK 2123
REE ++ + RD + EE Q + Q E+E+ +D + QL Q+ + +
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQ---EREQQLRHDRDRKFREEEQLLQEG---EEQQ 1683
Query: 2124 LKEQEFREQIHNLEDRLKKYEK 2145
L+ QE + E +L++ E+
Sbjct: 1684 LRRQERDRKFREEEQQLRRQER 1705
Score = 152 bits (384), Expect = 4e-36
Identities = 277/1380 (20%), Positives = 594/1380 (43%), Gaps = 153/1380 (11%)
Query: 875 SEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
S + + + +T+++ + DG ++ + L+E+E + R K ++++ + L
Sbjct: 2 SPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILELL 61
Query: 932 SAKEDSIHILNEEYETKFK---------NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLK 982
+ NE FK Q +++ K+ + +E+L + +E + +
Sbjct: 62 DLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRR 121
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1042
E + LE +++ K E + + G Q E+ E L + R+ ++
Sbjct: 122 FEPRDRQLEEEPGQRR-RQKRQEQERELAEG---------EEQSEKQERLEQRDRQRRDE 171
Query: 1043 VISIWEKKLNQQAEELQEIHEIQLQE-KEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
+W ++ Q E + E QLQ K E E F E++ +E+ L+ +G
Sbjct: 172 --ELWRQRQEWQEREERRAEEEQLQSCKGHETEE-------FPDEEQLRRRELLELRRKG 222
Query: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
++ ++ + + ET L+ EKL+ + + +E LQE+ +L+
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE---LQEEEEQLR 279
Query: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
L ++ R+ + + +++ Q L+ + K E++ + ++ E+
Sbjct: 280 KLERQELRR------ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ-------- 325
Query: 1222 KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL 1281
++ E E + +L + L R + R +++ E E + +QL
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE--------QEEERREQQL 377
Query: 1282 TEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI 1341
EQ + QL ++ + + E + ++ L++E QQ E+E
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE----QQLRREQE--- 430
Query: 1342 TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRK 1401
+E E + ++ LK ++ E K+ + E+E L++
Sbjct: 431 ----EERHEQKHEQERREQRLKREQEERRDWLKR--------EEETERHEQERRKQQLKR 478
Query: 1402 QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
+EE+ E ++++ + +E+ EQ + + +++ + R Q + +
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK--RQEEEERLQQRLRSEQ 536
Query: 1462 ELQIQLELKSKEAYEKDEQINLLKE------ELDQQNKRFDCLKGEMEDDKSKMEKK-ES 1514
+L+ + E + ++ +++E+ L +E + +Q+ +R LK E E + +++++ E
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
LE LK + +E E+ Q+ E E + + ++ E + Q + QE E
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
++ R +E E L+ + + E E ++E E +KS+ + + +LESE+
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR---IPKWQWQLESEAD 713
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
A+ +++ + ++ ++Q + EEK + + + E + Q+ E + +
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQ---EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1754
++ E S+ R + ++A E + Q EE+ QR L E+E+ QR
Sbjct: 771 WQAEEKSE-------RGRQRLSARPPLREQRER---QLRAEERQQREQRFLPEEEEKEQR 820
Query: 1755 VGQEKEETVSSHF---EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI 1811
Q +E F E + Q +ER +L+ E EDQ QE+ ++ ++ L
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER-RRSQEQRRDQKWRWQL- 878
Query: 1812 VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHR 1871
E++ ++ + AK L+ Q+ LQE+E Q E++ + R++E R
Sbjct: 879 ---EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR-------RRQEQER 928
Query: 1872 VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
EE + E+ Q L++ E + +E+ + + KL E + K
Sbjct: 929 QYREEEQLQQEEEQLLRE--------EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQE--REEKIKQEQEDL--E 1987
EREK+ +E ++ Q++ ++LR+E ++ ++E++++ ++++++QE+E L E
Sbjct: 981 RRRQEREKKYREEEELQ-QEEEQLLREEREKR---RRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 1988 LKHNSTLKQLMREF--NTQLAQKEQELEMTIKETINKAQEVEAELL--ESHQEETNQLLK 2043
+ L++ R++ +L Q+E++L +ET + QE+E + E Q+E QLL+
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERET-RRRQELERQYRKEEELQQEEEQLLR 1095
Query: 2044 KIAEKDDDLKRTAK-RYEEILDAREEEMTAKVRDLQTQLEELQKKY------QQKLEQEE 2096
+ EK +R + R EE L EE++ + R+ + + +EL+++Y QQ+ EQ
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREERE-KRRRQELERQYREEEEVQQEEEQLL 1154
Query: 2097 NPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPY 2156
+ EL+ Q ++ L + + +E +E+ +R + E+ + Y
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 2157 KGGNLYHTDVSLFGEPTEFEYLR--KVLFEYMMGRETKTMAKVITTVLKFPDDQTQKILE 2214
+ + +D+ EP + +R KV Y GRE + ++ + L+ D Q+Q+ L+
Sbjct: 1215 RDED-QRSDLKWQWEPEKENAVRDNKV---YCKGRENEQFRQLEDSQLR--DRQSQQDLQ 1268
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 272 bits (695), Expect = 3e-72
Identities = 422/1980 (21%), Positives = 847/1980 (42%), Gaps = 316/1980 (15%)
Query: 368 ETKRQMHETLEMKEEEIAQLRSR-------IKQMTTQGEELREQKEKSERAAFEELEKAL 420
E +++ HE + +E+ QL+S+ ++ T+ L Q +K E+ EK +
Sbjct: 255 ELEKEAHE----RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN----EDYEKMI 306
Query: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD----VMKKSSEE 476
++T E E+ E ++ + ++EE++SLQQ + + Q +V+ + + S E
Sbjct: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 477 QIAKLQKL----HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
+L + + A K L + + TR R+ + ++ L Q + Q+ +Q
Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
Query: 533 E------------------SLALEELELQ--------KKAILTESENKLRDLQQ--EAET 564
E +LA + ++LQ ++ +L ++ +LR + E E
Sbjct: 427 EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEA 486
Query: 565 YRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE-LESLKHQQ 623
+R R + +E L+ + + + + +HL + + +E+ + +E ++E L L +
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 624 DALWTEKLQ-VLKQQYQTEMEKLREKCEQE------KETLLKDKEIIFQA---HIEEMNE 673
+AL + L+ L +Q QTE+ + EQ E LK + +A + +NE
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 674 K-TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
L+K+ + Q +L L E V E+ + L Q D + E + +KN H
Sbjct: 607 ALALDKVGLNQ-QLLQLEEENQSVCSRMEAAEQARNAL--QVDLAEAEKRREALWEKNTH 663
Query: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
+ +E +Q + ++++ +++ L E + +E L + KR E
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
L +A + + ++A + +A E L ++L L + + LL + E + Q +
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 853 CTELDAHKIQVQDLMQ--------------QLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898
++Q+Q + Q +L+ + S+ EQ+ + + ++G
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEK 958
EQ K E + Q+RE +KE Q+L+ +S+ E E + K Q+ +ME
Sbjct: 844 LEQQK---AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 959 VKQKAKEMQETLKKKLLDQEAKLKKE-------LENTALELSQKEKQF-----NAKMLEM 1006
++ + +E + + L + + +KE L T EL+ +Q + K+ ++
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK---------LNQQAEE 1057
+ + GI L+T +E L E R+ +D+ ++ E+ L +Q E+
Sbjct: 961 KEQETTGI------LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 1058 L----------QEIHEIQLQEKEQEVAEL----------KQKILLFGCEKEE---MNKEI 1094
L Q + E ++QEK +E E K + L EKE+ + +E
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074
Query: 1095 TWLKEE---GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
++++ ++QD + E Q + K+ SA + L Q+ + +A E L + L E +
Sbjct: 1075 DSIRQQELSALRQD--MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEEL-EAS 1131
Query: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ EQ + + A+E K ++L +L++T+ + ++L + + N++ + L
Sbjct: 1132 HITEQQLRASLWAQE--AKAAQLQLRLRSTESQLEALAAEQQPGNQA--QAQAQLASLYS 1187
Query: 1212 ELAIQLDICCKKTEAL------------LEAKTNELIN-------ISSSKTNAILSRISH 1252
L L C+ L LE N + +++ A+ S +
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQL----------EEK 1302
K ++ + V +LE +L E++ ++ Q QL E K
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 1303 ENQIKS-------MKADIESLVTEKEALQKEG-GNQQQAASEKESCITQ----------- 1343
+N ++S A ++S + E + E G ++ + KE+ Q
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA 1367
Query: 1344 ---------LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNV----QLQNSI--- 1387
L+++L +A+ L EE++ ++ +L +Q +L V LQ ++
Sbjct: 1368 RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ-GELKVAQGKALQENLALL 1426
Query: 1388 --SLSEKEAAISSLRKQYDE-EK--------CELLD-QVQDLSFKVDTLSKEKISALEQV 1435
+L+E+E + +LR Q E EK ELL ++ + +VD L +E+I LE+
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD-LQQEQIQELEKC 1485
Query: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQ-------LELKSKEAYEKDEQINLLK--- 1485
++ + + T + ++EL+ LE + E +KD+ I +
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 1486 EELDQQNKRFDCLKGEMEDDKSKMEKKESNL-ETELKSQTARIMELEDHITQKTIEIESL 1544
++L +Q +CL E+E++ KME ++ + E E + +T R+ +T T+++E
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA-----LTHLTLDLEER 1600
Query: 1545 NEVLKNYNQQ-KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
++ L+ + Q D+E V +EL +E+D VK E+I L+ Q + +LE
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLA----REL-QERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 1604 KKKEL----EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQM 1659
+ +EL E + + + + K LE+ LE KL+ +R E ++QL+ +
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQ---IKLSLRERGRE---LTTQRQLMQER 1709
Query: 1660 EEKEEQYKKGTESHLSELNTKLQEREREV-----HI---------LEEKLKSVESSQSET 1705
E+ + K L + L+++E+EV HI LE++L+ + ET
Sbjct: 1710 AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769
Query: 1706 --LIVPRSAKNVAAYTEQEEADSQG-CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEET 1762
L+ R + V + +EA QG +++ + ++ QR L ++++ L+ + QE+++
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829
Query: 1763 VSSHFEMR---------CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVA 1813
++ + +K H E + H++Q+ L+EEL + ++ +
Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR--RLEEELAVEGRRVQAL-- 1885
Query: 1814 QHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL-VRQKEVHRV 1872
+ V + + + ++ L + + QE E+ + L+ + + L R +E+ +
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 1873 EMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
E +S++++ A + + + + K + L Q +L ++EA L+ L
Sbjct: 1946 RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 1933 AGAEREKQKLGKEI-----------VRLQKDLRMLRK---------EHQQELE-ILKKEY 1971
+ ++L + + +R Q+D++ L++ HQQE E +L+K
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL 2065
Query: 1972 DQEREEKIKQEQEDL----ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Q +E + QE+++L E + L Q +RE LAQKEQE+ + ++ET + +E
Sbjct: 2066 AQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI-LELRET-QQRNNLE 2123
Query: 2028 AELLESHQ-EETNQLLKKIAEKDDDLKRTAKRYEEIL---DAREEEMTAKVRDLQTQLEE 2083
A L SH+ + K+ + L+R +R + L +ARE E K +DL L +
Sbjct: 2124 A-LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Score = 255 bits (651), Expect = 4e-67
Identities = 444/2020 (21%), Positives = 822/2020 (40%), Gaps = 297/2020 (14%)
Query: 189 IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPL 248
+ +LR++L Q+A LQ++ D EE LQ L +R VD+ +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ---KLTGERDTLAGQTVDLQGEV 458
Query: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
L + E+ K + LE L+Q R L+R +Q +
Sbjct: 459 DSLSKERELLQKAREELR------------QQLEVLEQEAWR----LRRVNVELQLQGDS 502
Query: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQD--KGMVI 366
+KE QE+L ++E E+++++ M + K L + L E LE +G ++
Sbjct: 503 AQ---GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK----SERAAF--------- 413
+ + ++ L E+ IA+L S + T+ +LR K +E A
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 414 ----EELEKALSTAQKTEEARRKLKAEMDEQIKTIE-------------KTSEEERISLQ 456
EE + S + E+AR L+ ++ E K E + +EE LQ
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
Query: 457 QELSRVKQEVVDVMKKSSEEQ------IAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
+L +++E ++ KK SE + +L++LH+ E R+E+ L + +Q +E +E
Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ-EAKRQEEVLARAVQEKEALVRE- 737
Query: 511 MKVALE--------------------KSQSEYLKISQEKEQQESLALE----ELELQKKA 546
K ALE S E L+ S + QQ++ +E +LE+Q +
Sbjct: 738 -KAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 547 ILTESE---NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
+ E ++R L+ E +T R++ + + + L + + + K LE +K H K
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA---LEQQKAAHEK 853
Query: 604 EITVMVEKHKTELESLKHQQD------ALWTEKLQV---LKQQYQTEMEKLREKCEQEKE 654
E+ + EK E E HQQ+ +L EK+++ LK+Q QTEME ++ + E+E+
Sbjct: 854 EVNQLREKW--EKERSWHQQELAKALESLEREKMELEMRLKEQ-QTEMEAIQAQREEER- 909
Query: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK----ARHKLEEELSVL 710
T + Q E+ LE L Q EL S +L + + + K +E +L
Sbjct: 910 TQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGIL 969
Query: 711 KDQTDKMKQELEAKMDEQKNHHQ--QQVDSIIKEHEVSIQRTEKALKDQI----NQLELL 764
+ Q + ++EL+ + ++ Q+ S + + ++ +Q+ + LK Q+ + L+
Sbjct: 970 QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 765 LKERDKHLKEHQAHVENLEADIKRSEGEL----QQASAKLDVFQSYQSATHEQTKAYEEQ 820
+E + L+E Q + ++ +++R + L + +L V Q S ++ A +
Sbjct: 1030 EQEVQEKLRETQEY-NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEA----QKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
+ + Q + +L + LL ++V E EA Q+ + EL+A I Q L L Q ++
Sbjct: 1089 MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAK 1148
Query: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE----NMILQMREGQKKEIEILTQKLS 932
Q L ES+LE EQ+ Q + + LQ G E +LS
Sbjct: 1149 AAQLQLRLRST-ESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR---PELS 1204
Query: 933 AKEDSIHIL------NEEYETKFKNQE-----------KKMEKVKQKAKEMQETLKKKLL 975
DS + + FK + K+ Q + Q+T + L
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQT-RDVLR 1263
Query: 976 DQEAKLKKELENTALELSQ--KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL- 1032
DQ KL++ L +T E SQ E Q + L Q + + LE+ E E++
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323
Query: 1033 ---TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK--------------EQEVAE 1075
+ + R EL + + E++L Q A+E LQ E+++
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 1076 LKQKILLFGCEKEEMNKEITWLKEEGVKQ--------------DTTLNELQEQLKQKSAH 1121
+ + L E E + L+E+G + TL E +E+++
Sbjct: 1384 ARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ 1443
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL---KMLAEEDKRKVSELTSKL 1178
+ L + KA LE L +DL K +E QEQ+ EL + + E V E KL
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC--CKKTEALLEAKTNELI 1236
E+ + L+ E LE + LE +K + + Q KK LE EL
Sbjct: 1504 TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
+ K I + + + AL T + E +L+ + + + L
Sbjct: 1564 E-NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
+L+E++ ++KS + IE L +KE L ++ + Q ++ I L+ + +
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK--- 1679
Query: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS---------LRKQYDEEK 1407
+++E+L++ K+ + ++LT +Q + + LR + E +
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739
Query: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA-----QSRFTQHQNTVKE 1462
C+ + + +L D L ++ +V + S S+ +++ Q + + Q +KE
Sbjct: 1740 CQQ-EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798
Query: 1463 --LQIQLELKSKEAYEKDEQINLLKEELDQQN-------KRFDCLKGEMEDDKSKMEKKE 1513
LQ QL+ + ++D+++ L++E Q ++ D L+G +E ++++
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 1514 SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
L+ K Q R LE+ + + +++L EVL + + + K L+ Q E
Sbjct: 1859 GELQDH-KEQARR---LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQA 1914
Query: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES 1633
+E + + ++ L + + ELE + E + ++ +AL++ L
Sbjct: 1915 QEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
Query: 1634 AA---------KLAELKRKAEQKIAAIKKQL-----LSQMEEKEEQYKKGT--------E 1671
AA + AEL R E A ++ L S+ E+ + ++G +
Sbjct: 1975 AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ 2034
Query: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
+ +L L +R+ E+ +E+ + +E S ++ + + E+EE + +G Q
Sbjct: 2035 EDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQ 2094
Query: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS-SHFEMRCQYQERLIKLEHAEAK-QHE 1789
E ++++ Q+ E+E L R Q++ + H +E+ +KL+ E + Q E
Sbjct: 2095 SVRELQLTLAQK---EQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 1790 DQSMIGHLQE----ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF---DDVQKTL 1842
+ + L++ E+E + K L ++ K + + L+ D Q+ L
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 1843 QEK-ELTCQILEQK---------IKELDSCL---VRQKEVHRVEMEELTSKYEKLQALQQ 1889
Q++ ELT + LE++ EL S V+ EV VE E EK Q+
Sbjct: 2212 QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR 2271
Query: 1890 MDGRNKPTELLEENTEEKSKSHLVQPKLLSNME-------------AQHNDLEFKLAGAE 1936
++ + LE + + ++ L +E AQ LE A A
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATAS 2331
Query: 1937 REKQKLG---------------KEIVRLQKDLRMLRKEHQ 1961
Q+ G KE+V LQ L + RK+ Q
Sbjct: 2332 SPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
Score = 241 bits (615), Expect = 6e-63
Identities = 427/2025 (21%), Positives = 863/2025 (42%), Gaps = 271/2025 (13%)
Query: 248 LPQLEPQAEVFTKEENPESDGEPVVED-GTSVKTLETLQQRVKRQENLLKRCKETIQSHK 306
L ++PQ+ EE + + + E+ S + L+ Q+ +RQ L+++ + + ++
Sbjct: 8 LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67
Query: 307 EQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
C L EA + +R + +E+ +L+ +L + EQ + +
Sbjct: 68 SWCQELEKRLEATGGPIPQRWENVEE------PNLDELLVRLEE--------EQQRCESL 113
Query: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426
AE Q+ +E + LR ++++T R+
Sbjct: 114 AEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARD----------------------- 150
Query: 427 EEARRKLKAEMDEQI-KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485
E R++ + +M+++ K K +SL +E+ ++ ++ MK +++ + +L+ H
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE-MKSATDRDLMELKAEH 209
Query: 486 EK---ELARKEQELTKKLQTRE---------REFQEQMKVALEKSQS---EYLKISQEKE 530
+ L LT Q+RE RE Q+ + L K+Q E + SQE
Sbjct: 210 VRLSGSLLTCCLRLTVGAQSREPNGSGRMDGRE-PAQLLLLLAKTQELEKEAHERSQELI 268
Query: 531 QQESLA-LEELELQKK-----AILTESENK----------LRDLQQEAETYRTRILELES 574
Q +S LE+ ELQ + A+LT+S+ + LR+ + ET T ++E E+
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEA 328
Query: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT-VMVEK---------HKTELE---SLKH 621
SL ++ QE K + + K+IT VMVE+ H+ LE S+
Sbjct: 329 SLSRNAQEEKLSLQQVI-----------KDITQVMVEEGDNIAQGSGHENSLELDSSIFS 377
Query: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHI--EEMNEKTLEKL 679
Q D +K L + T + + Q+ + ++ Q H EE + ++L
Sbjct: 378 QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL 437
Query: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
E ++L+ + ++ L +E +L+ ++++Q+LE E + V+
Sbjct: 438 QKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQ 497
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
++ Q+ E Q +L L ++ER++ Q + LEA S EL
Sbjct: 498 LQGDSAQGQKEE-----QQEELHLAVRERERL----QEMLMGLEAKQSESLSELITLREA 548
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ--KKDVCTE-L 856
L+ ++ LA+ +Q + +L + L +VA++ A K E L
Sbjct: 549 LESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL 608
Query: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI-LQ 915
K+ + + QLE++N + ++++ Q + L+ E E+ ++ L EK + Q
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQA-RNALQVDLAEAEKRREALWEKNTHLEAQ 667
Query: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK--KMEKVKQKAKEMQETLKKK 973
+++ ++ E+ +E+ I + E++ + + ++E++ Q+AK +E L +
Sbjct: 668 LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
Query: 974 LLDQEAKLKKELE-NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN--QKEQIE 1030
+ ++EA ++++ L+ ++++Q A+ L+ G+S A LE++ + +Q
Sbjct: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-------GLSSAKELLESSLFEAQQQN 780
Query: 1031 SLTEVHRRELNDVISIWEKKLNQQAEELQ-EIHEIQLQ-EKEQEVAELKQKILLFGCEKE 1088
S+ EV + +L I + + Q E +Q E+ ++L+ + E+ AE ++ +
Sbjct: 781 SVIEVTKGQLEVQI----QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836
Query: 1089 EMNKEITWLKEEGVKQDTTLNELQEQL-KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
E + T L+++ + +N+L+E+ K++S H LA+ L+ +LE+ L +
Sbjct: 837 EQEGK-TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
E +Q Q E + AE S L T++E SL + ++ K L D S + +
Sbjct: 896 TEMEAIQAQREEERTQAE------SALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
+L +++ +Q + ++T +L+ + E ++ Q ++ + + +
Sbjct: 950 RLRQDMKVQ-KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL 1008
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEK---ENQIKSMKADIESLVTEKE--- 1321
V +L++QL + Q + Q+ + +E + +++ KA + + EKE
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 1322 -ALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD-- 1378
LQ+ +QQ S + + + E E + L+++E+KEK+ + + QL +
Sbjct: 1069 LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEEL 1128
Query: 1379 -----LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK--EKISA 1431
QL+ S+ E +AA LR + E + E L Q + ++ SA
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Query: 1432 LEQ----VDDWSNKFSEWKKKAQSRF--TQHQNTVKELQIQLELKSKEAYEK-DEQINLL 1484
L+Q V + + S A S + QN + L + L + + E ++ L
Sbjct: 1189 LQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL 1248
Query: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544
++L + + D L+ +++ K+E++ ++ E E + +L+ ++Q E +S
Sbjct: 1249 HQDLWKTQQTRDVLRDQVQ----KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE-KSK 1303
Query: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604
E +N + + +E E + LQ +R++ AE + + + + ++A E
Sbjct: 1304 WEGKQNSLESELMELHETMASLQ----------SRLRRAELQRMEAQGERELLQAAKENL 1353
Query: 1605 KKELEHVNLSVKSKEEELKAL----EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQME 1660
++EH+ +V + A ED + SA KL + ++E++ A Q L +
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERA----QALQEQG 1409
Query: 1661 EKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTE 1720
E + K + +L+ L L ERE EV L +++ +E +
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE----------------- 1452
Query: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE--TVSSHFEMRCQYQERLI 1778
+QK E +S+ + ++ L Q QE E+ +V H M Q +E+ +
Sbjct: 1453 ---------MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 1779 KLEHAEAKQHED--QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFD 1836
++ + ++ E ++ L+ +L E KK +I +Q + + K + + L +
Sbjct: 1504 TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 1837 DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKP 1896
+ ++ CQ ++ IKEL+ Q+E RV + LT E+ Q++ ++
Sbjct: 1564 E-----NHHKMECQ--QKLIKELEG----QRETQRVALTHLTLDLEERS--QELQAQSSQ 1610
Query: 1897 TELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
LE ++ ++ + + + + Q +L+ R+K+ L +++ R ++L ML
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQ-------RQKEHLTQDLERRDQEL-ML 1662
Query: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN--STLKQLMREFNTQLA--QKEQEL 2012
+KE Q LE + + EE ++Q + L + +T +QLM+E + K Q
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Query: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
+ + I + +E E E + H E +L ++ ++ L R +L RE+E+
Sbjct: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
Query: 2073 --------------KVRDLQTQLEE--------------LQKKYQQKLEQEENPGNDNVT 2104
K + LQ+QL+E LQ++ QQ QEE
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV---KEK 1839
Query: 2105 IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149
LQ L Q + + + Q+ +EQ LE+ L + V A
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884
Score = 232 bits (592), Expect = 3e-60
Identities = 380/1931 (19%), Positives = 801/1931 (41%), Gaps = 269/1931 (13%)
Query: 44 EQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKE-SLVRTSSRESL 102
E+L E E+ ++S ++ + LR E+L S ++ L R E + + +S+
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLR----EALESSHLEGELLRQEQTEVTAALARAEQSI 577
Query: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSL--NKEQLIQRLRRMERSLSSYRGKYSEL 160
L +T + +D+ + A L +++L +K L Q+L ++E S +
Sbjct: 578 AELSSSENTLKTEV-ADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636
Query: 161 VTAYQMLQRE----KKKLQGILSQSQ--DKSLRRIAELREELQMDQQAKKHLQEEFDASL 214
A LQ + +K+ + + ++ + L++ E ELQ D + + +EE L
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
E TQ+ L Q + + L + + E +E+
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQE------EVLARAVQEKEALVREKAALE-------- 742
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
++ +E +Q + Q L KE ++S + S E + QL+ ++Q + + K
Sbjct: 743 -VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
++ E L +L ++ EQ +A+ +++ LE ++ A + Q
Sbjct: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK---AAHEKEVNQ- 857
Query: 395 TTQGEELREQKEKSERAAFEELEKALSTAQKTE-EARRKLKAEMDEQ------------- 440
LRE+ EK +EL KAL + ++ + E +LK + E
Sbjct: 858 ------LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQ 911
Query: 441 ----IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE-EQIAKLQKLHEKELARKEQE 495
+ ++ +E+ER+SL + L + ++E+ D ++ Q K+QKL KEQE
Sbjct: 912 AESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL-------KEQE 964
Query: 496 LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555
T LQT+ +E Q ++K A + + + ++ +E+ SL ++++LQK+ +S+
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDD---LAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
Query: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK-- 613
+D Q +E +++ L+E + ++ + E E+ K + +++M ++ +
Sbjct: 1022 QDDSQRL---------VEQEVQEKLRETQEYNR---IQKELEREKASLTLSLMEKEQRLL 1069
Query: 614 --TELESLKHQQDALWTEKLQVL---KQQYQTEMEKLREKC-EQEKETLLKDKEIIFQAH 667
E +S++ Q+ + + +Q +++ +ME LR++ E+E + L ++ +++ +
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129
Query: 668 IEEMNEKTLE---------------KLDVKQTELESLSSEL--SEVLKARHKLEEELSVL 710
+ E+ L +L +++LE+L++E +A+ +L S L
Sbjct: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 711 KDQTDKM---KQELEAKMDEQKN-----HHQQQVDSIIKE----------------HEV- 745
+ + + EL D + Q S+ K H++
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 746 ----SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLD 801
Q+T L+DQ+ +LE L + + + +++L+ + +++ E + K +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL-------LTKQVAEVEAQKKDVCT 854
+S HE + + +L + + + ++ + ER L LT QV ++A +
Sbjct: 1310 SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA 1369
Query: 855 ELDAHKIQVQDL---MQQLEKQNSEME---QKVKSLTQVYESKLEDGNKEQEQ---TKQI 905
+ A I +DL L+ +N E+E ++ ++L + E K+ G QE Q
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT 1429
Query: 906 LVEKENMI----------LQMREGQKKEIEILTQKLSAKEDSIHILNEEYE------TKF 949
L E+E + + RE QK +E+L+ L + + + E+ + +
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA 1009
++ +++ +QK +E +++ D+E + + LE+ LEL +K+ +M ++
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQ-RNVLEHQLLELEKKD--------QMIES 1540
Query: 1010 NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
+ D +L T + +E H+ E ++KL ++ E +E + L
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMEC-------QQKLIKELEGQRETQRVALTHL 1593
Query: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD- 1128
++ E Q++ + ++ T L E ++D + +EQ+++ L QD
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Query: 1129 ---ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
+ +L E+++V ++ ++ L+E L ++K+ E R ELT++ + E
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR---ELTTQRQLMQERA 1710
Query: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
+ K + SLE L + +E+ Q + +EL +
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQ------------QEHIHELQELKDQ---- 1754
Query: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ 1305
L + HR KV E L+ + E+ +QL E + + Q QL+E +
Sbjct: 1755 -LEQQLQGLHR--KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA 1811
Query: 1306 IKSMKADIESLVTEKEALQ------KEGGNQQQAASEK-ESCITQLKKELSENINAVTLM 1358
+ ++E+L E++ Q KE + Q A E+ + + EL ++ +
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871
Query: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCE---LLDQVQ 1415
+EEL + + +L + L DL + + E+E A+ +L++Q E+ E +Q
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESR------EQEKALLALQQQCAEQAQEHEVETRALQ 1925
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
D + + KE+ LE + S ++ A++R Q + + L+ K +
Sbjct: 1926 DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL 1985
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
E+ E L L+ + ++E+ E E++ Q R E +
Sbjct: 1986 EQAE----LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE---DVQ 2038
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
Q + +E L++ +++ + K L Q++Q + + +EK N +E EE+
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQ--ENMIQEKQNLGQEREEE--------- 2087
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E+ + + + L++ KE+E+ L + + + L + + + ++K
Sbjct: 2088 ----EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Query: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
L ++E L L L++ E EK + + S ++T S + V
Sbjct: 2144 LEPRLQRE----------LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEV 2193
Query: 1716 AAYTEQE--EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
A + + E DS+ Q+ ++++ + +R L EKE+L T ++ R +
Sbjct: 2194 AMFLQASVLERDSE---QQRLQDELELTRRAL-EKERL-----HSPGATSTAELGSRGEQ 2244
Query: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833
+L ++ EA+ D ++ LE + + + + ++N+Q + LE
Sbjct: 2245 GVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQ--RHNVQLRSTLEQ 2302
Query: 1834 VFDDVQKTLQE 1844
V + +K +E
Sbjct: 2303 VERERRKLKRE 2313
Score = 185 bits (469), Expect = 5e-46
Identities = 328/1560 (21%), Positives = 669/1560 (42%), Gaps = 226/1560 (14%)
Query: 4 KLKQKISEEQQQLQ--QALAPAQASSNSSTPTRMRSRTSSFTEQLDEGT--PNRESGDTQ 59
+L+ ++ E+Q +++ QA + + S +M+ T L E +E D
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 60 SFAQKLQ--LRVPSVESLFRSPIKESLFRSSSKE-SLVRTSSRESLNRLDLDSSTASFDP 116
++L+ ++V ++ + I ++ + + +E R+ L L +SS+ D
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 117 PSDMDSEAEDL----VGNSDSLNK-EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREK 171
D+ + EDL V DS EQ +Q R + + + + + + EK
Sbjct: 1006 -MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 172 KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEE-KDQYISVLQTQVSL 230
++ +L ++ + ++ LR+++Q Q +K L + + +E K++ L + L
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Query: 231 LKQ---------------------------RLRNGPMNVDVL----KPLPQLEPQAEVFT 259
L++ RLR+ ++ L +P Q + QA++ +
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
Query: 260 K------------EENPESDGEPVVEDGTSVKTLETLQQRV----KRQENLLKRCKETIQ 303
E PE G + SV LE Q KR L E +
Sbjct: 1185 LYSALQQALGSVCESRPELSGGG--DSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
S + + + ++ L +++Q+LE+ AEK+++ T+L+D + + Q +++K
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQ-----MTTQGE-ELREQKEKSERAAFEELE 417
+ E +E+ E +A L+SR+++ M QGE EL + +++ A E L+
Sbjct: 1303 KWEGKQNSLESELMEL-HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 418 KALSTAQKTEEARRKLKAEMDE-----QIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 472
A+ A+ A L+ ++ ++K E SE ER QE +K K
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV----AQGK 1417
Query: 473 SSEEQIAKLQKLHEKELARKEQEL-TKKLQTREREFQEQM-KVALEKSQSEYLKISQEKE 530
+ +E +A L + LA +E+E+ T + Q +E E Q +M K ALE + K +QE +
Sbjct: 1418 ALQENLALLTQT----LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD 1473
Query: 531 -QQESL--------ALEELEL---QKKAILTESENKLRDLQQEAETYRT----RILELES 574
QQE + LE L + +++ LT ++R+L+++ ET R ++LELE
Sbjct: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533
Query: 575 SLEKSLQENKNQSKDL--------AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
++ ++ + Q +DL + LE E+N H E + K ELE + Q
Sbjct: 1534 K-DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK---ELEGQRETQRVA 1589
Query: 627 WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686
T L+++ Q + + + E + + +E+ Q +E+ + E+++ Q +
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL--QERDQEVKSQR-EQIEELQRQK 1646
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS 746
E L+ +L + +E + VL+DQ + + LE +++ K +++ + + ++
Sbjct: 1647 EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLM 1706
Query: 747 IQRTE------KALKDQINQLELLLKERDKHLKEHQAHVENLEA----------DIKRSE 790
+R E KA + + ++L+L++++K ++ Q H+ L+ + R
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766
Query: 791 GE----LQQASAKLDVFQSYQSATHEQTKAYEE----QLAQLQQKLLDLETERILLTKQV 842
GE L Q ++ V Q EQ + E+ QL + Q+ L + E L ++
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ 1826
Query: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ--- 899
+ + Q++ V + DA + ++ L++++ E++ + ++ E +G + Q
Sbjct: 1827 QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Query: 900 -----------EQTKQILVEKENMILQMREGQKKEIEILTQKLSA------KEDSIHILN 942
EQ K +L ++ Q +E + + + L A ++ + L
Sbjct: 1887 EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 943 EEYETKFKNQEKKMEKVKQKAKEMQETL---------KKKLLDQEAKLKKELE--NTALE 991
E ++ ++QE E + +A+ +QE L K++ L ++A+L + LE L+
Sbjct: 1947 AESQSS-RHQE---EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ 2002
Query: 992 LSQKEKQFNAKMLEMAQANSAG-ISDAVSRLETNQKEQIESLTEV-----HRRELNDVIS 1045
S Q +++ LE A G I D R + + ++ ++L + H++E ++
Sbjct: 2003 ASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL- 2061
Query: 1046 IWEKKLNQQAEE--LQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
EK L Q+ +E +QE + + +E+E+ L Q + + +EI L+E +
Sbjct: 2062 --EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRE--TQ 2117
Query: 1104 QDTTLNELQEQLKQKSAHVNSLAQD--ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
Q L L K SL D E +L+ LE+L+ L ++ +E+ +L
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 1162 MLAEEDKRKVSELT-------SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
+ + K VS L + + D E Q L+ E + ++LE + L S
Sbjct: 2178 LSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH----SPGAT 2233
Query: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
++ + + + + E+ + + + + + S Q R +++A V+ L
Sbjct: 2234 STAELGSRGEQGV---QLGEVSGVEAEPSPDGMEKQSWRQ-RLEHLQQA-------VARL 2282
Query: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQIK--SMKA----DIE-SLVTEKEALQKEG 1327
E +L N+ + Q+E + ++K +M+A +E S T Q++G
Sbjct: 2283 EIDRSRLQRH----NVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDG 2338
Query: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Q+ + ++ C+ +L+KE+ +TL +++ ++ + S++L L+ L +S+
Sbjct: 2339 RGQKNSDAK---CVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL 2395
Score = 155 bits (392), Expect = 4e-37
Identities = 283/1424 (19%), Positives = 592/1424 (41%), Gaps = 168/1424 (11%)
Query: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
EEQ+ LQQ++ + + K E + ++ + +L A +Q + Q+LEK+ +
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKR---L 77
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
E + Q +E N E+ ++LV E Q R E+ + K D
Sbjct: 78 EATGGPIPQRWE------NVEEPNLDELLVRLEEE--QQRCESLAEVNTQLRLHMEKADV 129
Query: 938 IH-ILNEEYETKFKNQEKKMEKVKQKAKEM---QETLKKKLLDQEAKLKKELENTALELS 993
++ L E+ E + + +++ +K + QE K L + +L L L
Sbjct: 130 VNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL--------LSLW 181
Query: 994 QKEKQFNAKMLEMAQANSAGISDAVS---RLETNQKEQIESLT-EVHRRELNDVISIWEK 1049
++ F LEM A + + + RL + LT RE N + +
Sbjct: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
Query: 1050 KLNQQAEELQEIHEIQLQ--EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
+ Q L + E++ + E+ QE+ +LK + L E ++ E++ L + KQ+
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN-- 299
Query: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF-LQEQLVELKMLAEE 1166
+ ++ +K V L + T+L H E L+++ +E LQ+ + ++ + E
Sbjct: 300 -EDYEKMIKALRETVEILETNHTELMEH----EASLSRNAQEEKLSLQQVIKDITQVMVE 354
Query: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNK--SLEDKSLEFKKLSEELAIQLDICCKKT 1224
+ +++ S HE S + S +++ + L + + ++
Sbjct: 355 EGDNIAQ---------------GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRR 399
Query: 1225 EALLE-----AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
+A+ + A E +N+ + + + R K+ +L+ ++
Sbjct: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ----AAS 1335
L++E+ L + ++ QLE E + ++ L + ++ Q + QQ+ A
Sbjct: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519
Query: 1336 EKE---SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
E+E + L+ + SE+++ + ++E L+ +E L ++ T++ L + +
Sbjct: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARA---EQS 576
Query: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
A +SS E +L LS + L+ +K+ +Q+ + E + SR
Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL----LQLEEENQSVCSR 632
Query: 1453 FTQHQNTVKELQIQL---ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
+ LQ+ L E + + +EK+ + ++ ++ +++++K ++
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 1510 EKKESNLETELKSQTARIMEL-------EDHITQKTIEIESL---NEVLKNYNQQKDIEH 1559
+KK S + ++ T ++ +L E+ + + E E+L L+ Q + +
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDR 752
Query: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE 1619
++L ++LQ E ++ + EA+++ +E ++ +++T + E + V+ +
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS---QMEEKEEQYKKGTESHLSE 1676
EL + E E A +L + ++ A+++Q + ++ + E+++K H E
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE 872
Query: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTY 1734
L L+ ERE LE +LK + ++ E + R E+ +A+S C +T
Sbjct: 873 LAKALESLEREKMELEMRLKE-QQTEMEAIQAQRE-------EERTQAESALCQMQLETE 924
Query: 1735 EEKISVL------QRNLTEKEKLLQRVGQE------KEETVSSHFEMRCQYQERLIKLEH 1782
+E++S+L Q+ L + + L+R+ Q+ KE+ + + + Q +R +K
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK--- 981
Query: 1783 AEAKQHEDQSMIGHLQEE----LEEK-------NKKYSLIVAQHVEKEGGKNNIQAKQNL 1831
A+QH D + LQEE L++K S +VAQ + + +Q K
Sbjct: 982 EAARQHRDD--LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 1832 ENVFDDVQKTLQEKE--LTCQILEQK-----IKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
++ +QK L+ ++ LT ++E++ ++E DS ++ R +M+E + ++L
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQ-PKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
A QM ELL + +EK L Q +LL +EA H + +
Sbjct: 1100 SA--QM-------ELLRQEVKEKEADFLAQEAQLLEELEASH------ITEQQLRASLWA 1144
Query: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT 2003
+E Q LR+ E Q LE L E + + + + L L + E
Sbjct: 1145 QEAKAAQLQLRLRSTESQ--LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ESRP 1201
Query: 2004 QLA------------QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
+L+ + +Q ++ + + AE + S + +Q L K + D
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQ 2111
L+ ++ EE L E E + +LQ +L + ++K + E + +MEL
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 2112 LAQKTTLISDSKLKEQEF---REQIHNLEDRLKKYEKNVYATTV 2152
+A + + ++L+ E RE + ++ L +++ A V
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Score = 118 bits (295), Expect = 7e-26
Identities = 216/1078 (20%), Positives = 468/1078 (43%), Gaps = 182/1078 (16%)
Query: 1 MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
+ + K+ ++ + + LQ A+ A+A ++++ RT+ +L E Q+
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 61 FAQKLQLRVPSVESLFRSP--IKESLFRSSSKESLVRTSSRE------------SLNRLD 106
++ +L+V ++L + + ++L + +R +E L LD
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
Query: 107 LDSSTASFDPPSDMDSEAEDLVGNSDSL-----NKEQLI----QRLRRMERSLSSYRG-- 155
L D + E E + L +EQ + +++R +E+ + R
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524
Query: 156 --KYSELVTAYQMLQREKKKLQGILSQ----------------SQDKSLRRIAELREELQ 197
+ EL QM++ ++ ++Q + Q + + I EL + +
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 198 MDQQAKKHLQ---EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKP-LPQLEP 253
+ A HL EE L+ + I L++ ++L + L+ V + + +L+
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR 1644
Query: 254 QAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ-SHKEQCTLL 312
Q E T++ D E +++ + ++ L+ + RQ +L+ E I+ S +E+ L
Sbjct: 1645 QKEHLTQDLE-RRDQELMLQK----ERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL 1699
Query: 313 TSEKEALQEQLDE----------RLQELEKI---KDLHMAEKTKLITQLRDAKNLIEQLE 359
T++++ +QE+ +E L+ ++ I K+ + + + I +L++ K+ +EQ
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL 1759
Query: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Q + ET L +E+EI L+ ++++ QGE KE+S ++ +E ++A
Sbjct: 1760 QGLHRKVGETSL----LLSQREQEIVVLQQQLQEAREQGE----LKEQSLQSQLDEAQRA 1811
Query: 420 LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA 479
L+ + EA ++ + + Q + +++ ++ + +L+Q +K+ ++ + +EQ
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL--QDHKEQAR 1869
Query: 480 KLQKLHEKELA---RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536
+L E+ELA R+ Q L + L E +EQ K AL Q + + +QE E E+ A
Sbjct: 1870 RL----EEELAVEGRRVQALEEVLGDLRAESREQEK-ALLALQQQCAEQAQEHEV-ETRA 1923
Query: 537 LEELELQKKAILTESENKLRDLQQEA-------ETYRTRILELESSLEKSLQENKNQSKD 589
L++ LQ +A+L E + +L L+ E+ E R R L+ +L K+ + + +
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
Query: 590 LAVHLEAEKNKHNKEITVMV-----EKHKTELE-SLKHQ------QDALWTEKLQVLKQ- 636
L E ++ T+ + H +LE +L+ Q QD + E +Q L+Q
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
Query: 637 --------QYQTEMEKLREK--CEQEKETLLKDKEIIFQAHIEE----MNEKTLE-KLDV 681
++Q E E+L EK ++ +E ++++K+ + Q EE +++ E +L +
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
Query: 682 KQTELESLSSELS------EVLKARHK---LEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Q E E L + E L HK +EE+ L ++++ELE +
Sbjct: 2104 AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTE 2163
Query: 733 QQQVDSIIKEHEVSIQRTE-KALKDQINQLELLLK----ERDKHLKEHQAHVENLEADIK 787
++++ K ++++ + KA + ++ + L+ ERD + Q +E ++
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Query: 788 R---------------SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
+ S GE ++ ++ S + +++ ++L LQQ + LE
Sbjct: 2224 KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283
Query: 833 TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL 892
+R + L H +Q++ ++Q+E++ +++++ Q ++
Sbjct: 2284 IDR------------------SRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI 2325
Query: 893 ----------EDGNKEQEQTKQILVE--KENMILQMR---EGQKKEIEILTQKLSAKE 935
+DG ++ + + E KE ++LQ + E ++K+ I +++E
Sbjct: 2326 SKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRE 2383
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 253 bits (645), Expect = 2e-66
Identities = 326/1443 (22%), Positives = 640/1443 (44%), Gaps = 232/1443 (16%)
Query: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK---L 433
L +K +++ LR ++ + L+E+K SE EL+K L Q ++ K L
Sbjct: 78 LALKRDDVTLLRQEVQDLQAS---LKEEKWYSE-----ELKKELEKYQGLQQQEAKPDGL 129
Query: 434 KAEMDEQIKTIEKTSEEERIS----------LQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
+ +++++E+ EE + +Q+ +++ E+ D+ K EE+ L++
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEER--SLRE 187
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
E+++ R +EL K+ Q+ L++ E + + +++ Q ++ + L+
Sbjct: 188 AAEQKVTRLTEELNKEATV----IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
++ + +++ + LQ + + I +L S L K QE +AV+++ E K
Sbjct: 244 RERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQE-------VAVYVQ-ELQKLKS 295
Query: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663
+ + +K++T E+L + K+Q T++E E+ E + K I
Sbjct: 296 SVNELTQKNQTLTENL-------------LKKEQDYTKLE------EKHNEESVSKKNIQ 336
Query: 664 FQAHIEEMNEKTLE-KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
H ++++ + L+ +L +T L + ELSE +A KL+EELS E+E
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS-----------EVE 385
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
K LK + QL+ +E+++H + Q+ + L
Sbjct: 386 TKYQH--------------------------LKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842
+ + +E +L +A +L EQ + E+L +Q++ DL+ + L +Q+
Sbjct: 420 HSKLLETERQLGEAHGRLK----------EQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
Query: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE-Q 901
E ++ +LD K Q Q+ + +++ + L QV + G+K+Q+ Q
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR---QIGDKDQKIQ 526
Query: 902 TKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK------K 955
+ L++K + + E KE E L K+ A E +LN+ E QE+ K
Sbjct: 527 NLEALLQKSKENISLLE---KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
++ + K+ QE L ++ +Q+A L+ ++ L L + N+++ E
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAA-QDRVLSLETSVNELNSQLNES--------K 634
Query: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ--LQEKEQEV 1073
+ VS+L+ QI++ TE+ ++S K Q+A+ + Q LQ+K+QE+
Sbjct: 635 EKVSQLDI----QIKAKTEL-------LLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133
++ ++ + ++ + + L+ + L+++ ++ + L D ++K
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
Query: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193
A E+ DL + + NT L+ + EL E +K VS L+ E +S+K
Sbjct: 744 ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
Query: 1194 KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
K + + +F+ LS+E IQ + + ++ EL + K A+++ +S
Sbjct: 804 KQEEEKQILKQDFETLSQETKIQHE----ELNNRIQTTVTELQKVKMEK-EALMTELSTV 858
Query: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE-EKENQIKSMKAD 1312
+ + +KV ++L + SE E + ++ L + ++ HQL+ + EN +K K
Sbjct: 859 KDKLSKVSDSL---KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 1313 IESLVTEKEA---LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI 1369
+SL EKEA L+ E + Q+ + ++ + Q +KE + + +K+ ++KK +I
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 1370 SSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
+L +L I++ +K + L++Q + EL KEKI
Sbjct: 976 EALQGEL---------KIAVLQKTELENKLQQQLTQAAQEL------------AAEKEKI 1014
Query: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL--KEE 1487
S L+ + K E K+ QS F ++ + L + +LKS E Q +L+ + +
Sbjct: 1015 SVLQNNYE---KSQETFKQLQSDFYGRESEL--LATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 1488 LDQQNKRFDCL---KGEMEDDKSKME--------------KKESNLETELKSQTARIMEL 1530
+ QNK L K +E D +K E K++S E EL ++ +++ E+
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Query: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
E+ ++ EI LNE LK++ KL+ +E+ KD + ++K L L
Sbjct: 1130 EEIKCRQEKEITKLNEELKSH-------------KLESIKEITNLKDAKQLLIQQK-LEL 1175
Query: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELK----ALEDRLESESAAKLAELKRKAEQ 1646
+ + S+KA +E +K+ + + VK +EEELK E +L SE K +K K E+
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK-KHEE 1234
Query: 1647 KIAAIKKQLLSQMEEKEEQYK--KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
A + Q+ + E K + ++ +SEL + + E+ +LE +V+++Q E
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE---ATVQNNQDE 1291
Query: 1705 -TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763
++ R K +G ++K + K+ LQR L +Q +G+E +
Sbjct: 1292 RRALLERCLK------------GEGEIEK-LQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Query: 1764 SSH 1766
H
Sbjct: 1339 IKH 1341
Score = 201 bits (512), Expect = 5e-51
Identities = 306/1333 (22%), Positives = 586/1333 (43%), Gaps = 198/1333 (14%)
Query: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK--LLDQEAKLKKELENT 988
L+ K D + +L +E + + + +++ K ++E+++ L+K L QEAK + ++
Sbjct: 78 LALKRDDVTLLRQEVQ----DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW- 1047
+ EL E+Q LE AQ + I K+ E E+ D+ S +
Sbjct: 134 SAELQSLEQQ-----LEEAQTENFNIKQ--------MKDLFEQKAAQLATEIADIKSKYD 180
Query: 1048 -EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
E+ L + AE+ +L ++ + +LK ++L + +++ LK+E V+ T
Sbjct: 181 EERSLREAAEQKVTRLTEELNKEATVIQDLKTELL-----QRPGIEDVAVLKKELVQVQT 235
Query: 1107 TLNELQEQLKQKSAHVNS----LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
++ + + +++S + L +A + +L +L K +E ++L +LK
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 1163 LAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
E +K LT L ++++ L+ H + + S KK + Q D+ C+
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS--------KKNIQATLHQKDLDCQ 347
Query: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
+ ++ L A S + + I +S T K+KE L L+A+ +QL
Sbjct: 348 QLQSRLSA--------SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK----E 1338
+++ +Q QL+ + NQ+ S + E + E KE Q+Q +SEK E
Sbjct: 400 QQREEK----EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKLMDKE 452
Query: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
+ L+ +LS ++E+LKEK + L QL Q Q +L + A
Sbjct: 453 QQVADLQLKLSR-------LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA--K 503
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTL------SKEKISALEQV-DDWSNKFS--EWKKKA 1449
LR+ ++ + ++L Q+ D K+ L SKE IS LE+ +D K E +
Sbjct: 504 LREAQNDLE-QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 1450 QSRFTQHQNTVKELQIQL--ELKSKEAYEKDEQINLLKEELDQQNK---------RFDCL 1498
++ + +T++E QL +LK++ K Q NL + +Q+ +
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 1499 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
E+ ++ ++K S L+ ++K++T ++ E T + ++++ + +N Q K E
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 1559 HKELVQ-------KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHV 1611
++ KLQ QE + ++ +KE +EK L+LE + ELE + K+LE
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT----EELEGQIKKLEAD 738
Query: 1612 NLSVK-SKEEELKALEDR--------LESESAAKLAELKR-----------KAEQKIAAI 1651
+L VK SKE+ L+ L+ + L + +K E+++ K + + +I
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 1652 KKQLLSQMEEKE------EQYKKGTESHLSELN-------TKLQEREREVHILEEKLKSV 1698
K++L Q EEK+ E + T+ ELN T+LQ+ + E L +L +V
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCV---QKTYEEKISVLQ----RNLTEKEKL 1751
+ S+ V S KN + E+E + + +KT +E LQ L E+++L
Sbjct: 859 KDKLSK---VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 1752 LQRVGQEKEETVSSHFEMRCQYQERLIKLEHA-EAKQHEDQSMIGHLQEELEEKNKKYSL 1810
+ + +EKE + E+ QE+LI+ ++ + + E+Q + G++ E + +K
Sbjct: 916 KKSLEKEKEASHQLKLELNSM-QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDD-----VQKTLQEKELTCQIL------EQKIKEL 1859
I A E K + K LEN Q+ EKE + ++ K+L
Sbjct: 975 IEALQGEL---KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQ--------QMDGRNKPTE-------LLEENT 1904
S ++ ++L S EKL Q Q+ +NK + LE+++
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091
Query: 1905 EEKSKSHLVQPKLLSNMEAQHNDLE-------FKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
+K + + K L +++ + + E KLA E K + KEI +L ++L+ +
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ---ELEM 2014
E +E+ LK + ++ + Q++ +L+ K +S + +E Q K+Q E E
Sbjct: 1152 LESIKEITNLK-----DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
Query: 2015 TIKETINKAQEVEAEL------LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
KE I K ++ +E+ ++ H+E +L +I +++L T K+ + R
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL-GTVKKEWQSSQRRVS 1265
Query: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQE----ENPGNDNVTIMELQTQLAQKTTLISDSKL 2124
E+ + DL+ ++ L+ Q ++ E I +LQT++ + + ++
Sbjct: 1266 ELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTA 1325
Query: 2125 KEQEFREQIHNLE 2137
QE + +L+
Sbjct: 1326 AVQELGRENQSLQ 1338
Score = 193 bits (490), Expect = 2e-48
Identities = 266/1196 (22%), Positives = 507/1196 (42%), Gaps = 177/1196 (14%)
Query: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV 1122
E L K +V L+Q++ + + KE W EE K+ LQ+Q + V
Sbjct: 75 ESNLALKRDDVTLLRQEVQ----DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
Query: 1123 NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV---------------ELKMLAEED 1167
+ + L+ LE+ + + N ++K+ L EQ E + L E
Sbjct: 131 TDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
Query: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
++KV+ LT +L Q LK+ + +ED ++ K+L + + +D + E
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTL-MDNMTLERERE 247
Query: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
E +E + S ++ + IS + K + + + + +L++ + +LT++ T
Sbjct: 248 SEKLKDECKKLQSQYASSEAT-ISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 1288 LN---ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + +Q +LEEK N+ K +I++ + +K+ + Q S E+ + ++
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL---DCQQLQSRLSASETSLHRI 363
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN----------VQLQNSIS------ 1388
ELSE A +KEEL E + + L + L +QLQ+ I+
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 1389 ------LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
L E + R+ E+ + QV DL K+ L ++ + + ++
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
Query: 1443 SEWKKKAQSRFTQHQNT---VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
+ K++ Q + Q+T ++E Q LE ++ +KD++I L+ L + + L+
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
Query: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559
E ED +K++ E ET + +Q ++ ++H Q+ ++ L E LKN ++ H
Sbjct: 544 KEREDLYAKIQAGEG--ETAVLNQ----LQEKNHTLQE--QVTQLTEKLKNQSES----H 591
Query: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE 1619
K+ + L + +E+ ++ A++++L+LE V + ++L K+++ +++ +K+K
Sbjct: 592 KQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 1620 EELKALEDRLESE---------SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670
E L + E ++ +A + K++ KI Q+ +++++K+E +
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-L 707
Query: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
ESHL E K E++ LE ++K +E+ E V A EQ D Q
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE----------VKASKEQALQDLQQQR 757
Query: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790
Q + L+ TE K L+ EKE S+ +++ + E L ++ KQ E+
Sbjct: 758 QLNTD-----LELRATELSKQLE---MEKEIVSSTRLDLQ-KKSEALESIKQKLTKQEEE 808
Query: 1791 QSMIGHLQEEL--------EEKNKKYSLIVAQ----HVEKEGGKNNIQA-KQNLENVFDD 1837
+ ++ E L EE N + V + +EKE + K L V D
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 1838 VQKTLQE--------------KELTCQILEQKI-----------KELDSCLVRQKEV-HR 1871
++ + E E TC+ L+ ++ KEL L ++KE H+
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 1872 VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA-------Q 1924
+++E + + + +QA + K + L+ N E +S + K + ++ Q
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 1925 HNDLEFKLA----------GAEREK-QKLGKEIVRLQKDLRMLRKE-HQQELEILKKEYD 1972
+LE KL AE+EK L + Q+ + L+ + + +E E+L D
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 1973 QER-EEKIKQEQEDLELKHNSTLKQ--LMREFNTQLAQKEQEL---EMTIKETINKAQEV 2026
+ EEK+ QEDL N Q L++E T A EQ+ E ++E Q++
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
Query: 2027 EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
+ E +E N+ K+AE ++ R K ++ + + ++++ + Q
Sbjct: 1109 QKEKSLKEKELVNEK-SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167
Query: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
QQKLE LQ + + K +Q ++Q+ E+ LKK
Sbjct: 1168 LIQQKLE--------------LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209
Score = 187 bits (474), Expect = 1e-46
Identities = 294/1325 (22%), Positives = 574/1325 (43%), Gaps = 177/1325 (13%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTR--MRSRTSSFTEQLDEGTPNRESGDTQS 60
K++K ++ QL +A ++ + R + + TE+L N+E+ Q
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL-----NKEATVIQD 209
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSS-KESLVRTSSRESLNRLD----LDSSTASFD 115
+L L+ P +E + + +K+ L + + +++ RES D L S AS +
Sbjct: 210 LKTEL-LQRPGIEDV--AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
Query: 116 P------------PSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTA 163
P ++ ++L S+N +L Q+ + + +L Y++L
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQKLKSSVN--ELTQKNQTLTENLLKKEQDYTKLEEK 324
Query: 164 YQMLQREKKKLQGILSQ-------------SQDKSLRRI-----------AELREELQMD 199
+ KK +Q L Q + + SL RI +L+EEL
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
Query: 200 QQAKKHLQEEF---DASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV----LKPLPQLE 252
+ +HL+ EF EEK+Q+ LQ++++ L +L + LK QL
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLET-LQQRVKRQENLLKRCKETIQSHKEQCTL 311
+ ++ KE+ V + + LE L+++V L + +T Q H+EQ L
Sbjct: 445 SE-KLMDKEQQ-------VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
Query: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
S L+E ++ Q L +I D + L L+ +K I LE+++ + A+ +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 372 QMHET--LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
ET L +E+ L+ ++ Q+T E+L+ Q E S + A E L + +E
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLT---EKLKNQSE-SHKQAQENLH------DQVQEQ 605
Query: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL 489
+ L+A D ++ ++E + E L + +V Q +D+ K AK + L E
Sbjct: 606 KAHLRAAQD-RVLSLETSVNELNSQLNESKEKVSQ--LDIQIK------AKTELLLSAEA 656
Query: 490 ARKEQ--ELTKKLQTREREFQE-QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
A+ Q +L L T + Q+ Q ++ +Q + + + +Q+ LE + K
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
E K +L+ + + LE+++S E++LQ+ Q + L LE + +K++
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD-LQQQRQLNTDLELRATELSKQLE 775
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ E + L+ + +AL + K ++ KQ+ + ++ K Q+ ETL ++ +I
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK------QDFETLSQETKI---- 825
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
EE+N + +++ +EL +V + L ELS +KD+ K+ L+
Sbjct: 826 QHEELNNR-----------IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN-QLELLLKERDKHLKEHQAHVENLEAD 785
E + +Q+ +I+ +++T K LK Q+ Q+E LKE+ + L+
Sbjct: 875 EFEKENQKGKAAIL-----DLEKTCKELKHQLQVQMENTLKEQ-----------KELKKS 918
Query: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
+++ + Q +L+ Q K E++ QLQ + +L+ KQ+ +
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905
+ + K + + ++Q + Q ++ + ++K+ L YE K QE KQ+
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE-------KSQETFKQL 1031
Query: 906 LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE 965
+ G++ E+ Q L + E+ + + E+ + +NQ K+ Q+ K
Sbjct: 1032 QSD--------FYGRESELLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQELKT 1082
Query: 966 MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ 1025
+ TL++ +E +L++ + AL+ QKEK K L ++ A I + R E
Sbjct: 1083 AKATLEQDSAKKEQQLQERCK--ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 1026 KEQIESLTEVHRRELNDVISIWEKK--LNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
+ E L + ++ ++ + K L QQ ELQ + EQE + Q+IL
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE--KRNQQIL-- 1196
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
K+++ KE LK+E ++++ +L ++K+K + ++E KL + L +L
Sbjct: 1197 ---KDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
KE Q ++ EL+ ++ + +++ L + ++ +E ++L K +E
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
Query: 1204 LEFKKLSEEL-----AIQ------LDICCKKTEALLE--AKTNELIN-ISSSKTNAILSR 1249
+ +L +L A+Q + K T+AL A+ NE+ N ++ K ++ R
Sbjct: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVR 1370
Query: 1250 ISHCQ 1254
HC+
Sbjct: 1371 RHHCR 1375
Score = 147 bits (372), Expect = 9e-35
Identities = 195/861 (22%), Positives = 365/861 (42%), Gaps = 85/861 (9%)
Query: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS----LSEK 1392
K +T L++E+ + ++ LKE+K L K+L Q +++
Sbjct: 81 KRDDVTLLRQEVQD-------LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 1393 EAAISSLRKQYDEEKCELLD--QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
A + SL +Q +E + E + Q++DL + +I+ ++ D E ++
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKD-EQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
+R T+ N KE + +LK++ E + +LK+EL Q D + E E + K+
Sbjct: 194 TRLTEELN--KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEI-------ESLNEVLKNYNQQKDIEHKEL 1562
+ + L+++ S A I +L + + E+ + L + Q+ + L
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
Query: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQ----VYSMKAELETKKKELEHVNLSVKSK 1618
++K Q + +L EEK N +++ I +Q +++ L + L +++ + K
Sbjct: 312 LKKEQDYTKL-EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
E + L++ L SE K LK + +Q L Q E++EQ+ +S +++L+
Sbjct: 371 GEATQKLKEEL-SEVETKYQHLKAEFKQ---------LQQQREEKEQHGLQLQSEINQLH 420
Query: 1679 TKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI 1738
+KL E ER++ +LK SE L+ EQ+ AD Q + + EE++
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLM----------DKEQQVADLQLKLSR-LEEQL 469
Query: 1739 SVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
N TE + L + Q+ +E + + +E LE + + I +L+
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
Query: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKE 1858
L++ + SL+ EKE + ++ AK V LQEK T L++++ +
Sbjct: 530 ALLQKSKENISLL-----EKE--REDLYAKIQAGEGETAVLNQLQEKNHT---LQEQVTQ 579
Query: 1859 LDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL 1918
L L Q E H+ E L + ++ +A + LE + E + + +
Sbjct: 580 LTEKLKNQSESHKQAQENLHDQVQEQKA--HLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK 1978
S ++ Q L AE K ++ + ++ QQEL + + DQ K
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV-TAK 696
Query: 1979 IKQEQEDLELKHNSTLKQLMREFNTQ---LAQKEQELEMTIKETINKAQEVEAELLESHQ 2035
++ +QE H S L+ ++E+ + L QK +ELE IK+ + EV+A +
Sbjct: 697 LQDKQE-----HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS-----K 746
Query: 2036 EETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
E+ Q L++ + + DL+ A + L+ +E +++ DLQ + E L+ Q+ +QE
Sbjct: 747 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTP 2155
E E Q TL ++K++ +E +I L+K + A
Sbjct: 807 E----------EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 2156 YKGGNLYHTDVSLFGEPTEFE 2176
L SL +EFE
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFE 877
Score = 141 bits (355), Expect = 8e-33
Identities = 217/998 (21%), Positives = 433/998 (43%), Gaps = 136/998 (13%)
Query: 2 FKKLKQKISEEQQ---QLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDT 58
FK+L+Q+ E++Q QLQ + S T ++ EQ + + D
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLH-SKLLETERQLGEAHGRLKEQRQ--LSSEKLMDK 451
Query: 59 QSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPS 118
+ LQL++ +E + + S + + L +T + + S+TA
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNS---TELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
Query: 119 DMDSEAEDLVGNSDSL--NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
+ + +G+ D N E L+Q+ + ++S + +L Q + E
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKE---NISLLEKEREDLYAKIQAGEGET----A 561
Query: 177 ILSQSQDKS---LRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV-------LQT 226
+L+Q Q+K+ ++ +L E+L+ ++ K QE ++E+ ++ L+T
Sbjct: 562 VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 227 QVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED--GTSVKTLETL 284
V+ L +L V L Q++ + E+ E ++ +++ T+ L+
Sbjct: 622 SVNELNSQLNESKEKVSQLDI--QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ---LDERLQELE-KIKDLHMAE 340
QQ + + L + +Q +E C+ L S + +E+ L+++ +ELE +IK L
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
++ + ++L +Q + + + + T ++ + LEM++E ++ R +++ + E
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRAT--ELSKQLEMEKEIVSSTRLDLQKKSEALES 797
Query: 401 LREQ--KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
++++ K++ E+ ++ + LS Q+T+ +L + + ++K E+ +L E
Sbjct: 798 IKQKLTKQEEEKQILKQDFETLS--QETKIQHEELNNRIQTTVTELQKVKMEKE-ALMTE 854
Query: 459 LSRVKQE---VVDVMKKSSEE----------QIAKLQKLHEK---------ELARKEQEL 496
LS VK + V D +K S E I L+K ++ E KEQ+
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914
Query: 497 TKKLQTREREFQEQMKVALEKSQSEY------LKISQEKEQQESLALEEL----ELQKKA 546
KK +E+E Q+K+ L Q + LK ++++EQQ + EL E +KK
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 547 I-------------LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH 593
I TE ENKL Q+ T + L E LQ N +S++
Sbjct: 975 IEALQGELKIAVLQKTELENKL----QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 594 LEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV----------------LKQQ 637
L+++ E+ + K+ E L Q+ L + + Q+ L+Q
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 638 YQTEMEKLREKCEQ----EKETLLKDKEIIFQ----AHIEEMN---EKTLEKL--DVKQT 684
+ ++L+E+C+ +KE LK+KE++ + A IEE+ EK + KL ++K
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH 1150
Query: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
+LES+ E++ + A+ L ++ L+ + D +K A ++++K + Q D + KE E
Sbjct: 1151 KLESIK-EITNLKDAKQLLIQQKLELQGKADSLK----AAVEQEKRNQQILKDQVKKEEE 1205
Query: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
+K ++ +L +KE++ +K+H+ + L I L + Q
Sbjct: 1206 ----ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261
Query: 805 SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCT---ELDAHKI 861
S +QT ++A L+ + + + ER L ++ + E + + + T EL
Sbjct: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Query: 862 QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
+Q+L ++N ++ K TQ K + N+ Q
Sbjct: 1322 NTTAAVQELGRENQSLQIK---HTQALNRKWAEDNEVQ 1356
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 244 bits (624), Expect = 5e-64
Identities = 302/1261 (23%), Positives = 595/1261 (47%), Gaps = 180/1261 (14%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+++Q+LT ++ +R +K+ + + K+ Q Q+E + +E
Sbjct: 808 LARKAFAKRQQQLTA-MKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKED 866
Query: 541 ELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
ELQK K ++EN+L++L+Q+ +++ E ++ L++ LQ + ++ EAE
Sbjct: 867 ELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQA------ETELYAEAE-- 914
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
E+ V + K ELE + H+ +A E+ + QQ Q E +K+ ++ +E L ++
Sbjct: 915 ----EMRVRLAAKKQELEEILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 660 KEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
+ + +E++ E ++KL+ + ++ +++LS K R LEE +S L T+ +
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS---KERKLLEERISDLT--TNLAE 1024
Query: 719 QELEAK-MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK----ERDKHLK 773
+E +AK + + KN H+ S+I E EV +++ EK+ + ++ +L+ L+ + + +
Sbjct: 1025 EEEKAKNLTKLKNKHE----SMISELEVRLKKEEKS-RQELEKLKRKLEGDASDFHEQIA 1079
Query: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
+ QA + L+ + + E ELQ A A+LD + ++ ++ + E ++ LQ+ DL++
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE---DLDS 1136
Query: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN---SEMEQKVKSL------ 884
ER K E QK+D+ EL+A K +++D + Q ++ EQ+V L
Sbjct: 1137 ERAARNK----AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 885 -TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
T+ +E+++++ ++ Q + L E+ + + K + L ++ + + +L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 944 ---EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
E E K K E ++++++ K + E + +L D+ KL+ E+E+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDKVHKLQNEVESVT----------- 1300
Query: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
ML A+ + ++ V+ L + ++ E L E R++LN +S ++L ++ LQ+
Sbjct: 1301 -GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQD 1357
Query: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK------EEGVKQ-DTTLNELQE 1113
QL E+ + L++ I + + K++ EEG K+ + L +
Sbjct: 1358 ----QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173
Q ++K+A + L + + +L+ L+ L VDL+ Q QLV E+ +RK +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--------QRQLVSN---LEKKQRKFDQ 1462
Query: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
L ++ K ++ + E + E K+L + EE A++ ++T +L+A+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE-ALEAKEELERTNKMLKAEME 1521
Query: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
+L+ SSK + + H K K AL E Q+ EE T
Sbjct: 1522 DLV---SSKDD-----VGKNVHELEKSKRAL----------ETQM----EEMKT------ 1553
Query: 1294 QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSENI 1352
QLEE E+++++ + L +AL+ + QA E+ E QL+++L E
Sbjct: 1554 ----QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY- 1608
Query: 1353 NAVTLMKEELKEKKVEISSLSKQLTDL-NVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
T +++E K++ + ++ K DL +++LQ ++ +E AI LRK
Sbjct: 1609 --ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK---------- 1656
Query: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
L ++ +E A D+ E +KKA+S +Q+Q +L +
Sbjct: 1657 -----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL------EADLMQLQEDLAA 1705
Query: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
E K Q +L KEEL ++ + ++D+K ++E + + LE EL+ + + +
Sbjct: 1706 AERARK--QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 1532 DHITQKTIEIESLNEVL----------KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581
D + + T + E L+ L ++ QQ + ++KEL KL + + K
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK----- 1818
Query: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
+ I LE ++ ++ ++E + +E + S+K K+++LK E L+ E K+AE
Sbjct: 1819 -FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVEDERKMAEQY 1875
Query: 1642 RKAEQKIAAIKKQLLSQMEEKEEQY------KKGTESHLSELNTKLQEREREVHILEEKL 1695
++ +K A KQL Q+EE EE+ ++ + L E + REV+ L+ KL
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 1696 K 1696
+
Sbjct: 1936 R 1936
Score = 204 bits (519), Expect = 8e-52
Identities = 267/1195 (22%), Positives = 524/1195 (43%), Gaps = 171/1195 (14%)
Query: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
K + + Q+ + ++M + +EL++ KE+ ++A E E +Q TEE + L E +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--KNLLQEQLQ 904
Query: 440 QIKTIEKTSEEERISL---QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
+ +EE R+ L +QEL +E++ M+ EE+ + Q+L + +Q L
Sbjct: 905 AETELYAEAEEMRVRLAAKKQEL----EEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 497 TKKLQTREREFQEQMKVALEK--SQSEYLKISQE---------KEQQESLALEELELQKK 545
+ Q E E Q K+ LEK ++++ K+ E K +E LEE
Sbjct: 961 DLEEQLEEEEAARQ-KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605
L E E K ++L + + + I ELE L+K ++++ + + L LE + + +++I
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 606 TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
+ + ++ LK Q L +++ Q + +L ++ Q+ L K +E+ +
Sbjct: 1079 ADL----QAQIAELKMQ--------LAKKEEELQAALARLDDEIAQKNNALKKIREL--E 1124
Query: 666 AHIEEM-----------NEKTLEKLDVKQTELESLSSELSEVL-------KARHKLEEEL 707
HI ++ N+ +K D+ + ELE+L +EL + L + R K E+E+
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEV 1183
Query: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
+VLK D+ + EA++ E + H Q V+ + ++ E +R + L LE +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENAD 1242
Query: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
L+ + +E K+ E ++Q+ +K + ++ +++ + ++ +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
L + E + I L K VA + +Q +D Q+L+Q+ +Q + K++ L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQD-----------TQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKK------EIEILTQKLSAKEDSIHIL 941
S + ++E E + + + +Q+ + +KK +E L + + I L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
++YE K + K+EK K + ++ + L LD + +L LE +K+++F+
Sbjct: 1412 TQQYEEKAAAYD-KLEKTKNRLQQELDDLVVD-LDNQRQLVSNLE-------KKQRKFDQ 1462
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ E +S +D R E +E+ E K A L+E
Sbjct: 1463 LLAEEKNISSK-YADERDRAEAEAREK-------------------ETKALSLARALEEA 1502
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
E + +E E+ LK ++ K+++ K + L++ +T + E++ QL++
Sbjct: 1503 LEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSL--------KENTFLQEQLVELKMLAEEDKRK--- 1170
+ + + +L+ +++ L+ + L ++ LQ QL E + E+++++
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 1171 ----VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
+L LK + + S E++ K L + K EL D + E
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE---DARASRDEI 1678
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKV----KEALLIKTCTVSELEAQL---R 1279
AK NE K ++ + + Q K+A L K EL + L
Sbjct: 1679 FATAKENE------KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
L +E+ L Q +LEE++ +++M + + E L E ++ A + ES
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792
Query: 1340 CITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
QL+++ E + + M+ +K K K I++L ++ L Q++ EK+AA S
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKS 1850
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
L KQ D++ E+L QV+D + K+ + ++ E +K +R
Sbjct: 1851 L-KQKDKKLKEILLQVED---------ERKM---------AEQYKEQAEKGNAR------ 1885
Query: 1459 TVKELQIQLELKSKEAYEKDEQINL----LKEELDQQNKRFDCLKGEMEDDKSKM 1509
VK+L+ QLE EA E+ ++IN L+ ELD+ + + + E+ KSK+
Sbjct: 1886 -VKQLKRQLE----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 188 bits (477), Expect = 6e-47
Identities = 270/1194 (22%), Positives = 528/1194 (44%), Gaps = 158/1194 (13%)
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELEN-----------TALELSQKEKQFNAKMLEMAQ 1008
K AK Q+ K++ + +L N L+++++E++ AK
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------ 864
Query: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAEELQEIHE--I 1064
D + + + Q++ L E+ ++ +L + ++ +++L + E E E +
Sbjct: 865 ------EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
+L K+QE+ E+ ++ E+E+ ++ L+ E K + +L+EQL+++ A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 1125 LAQDETKLKAHLEKLEVDL-------NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
L ++ +A ++KLE ++ NK KE L+E++ +L E++ K LT K
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-K 1034
Query: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
LK E S+ S E K E E +KL +L ++ A L+A+ EL
Sbjct: 1035 LKNKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQIAELKM 1090
Query: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
+ K + + ++ + AL + ELE + L E+ ++ + +A
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKA-- 1144
Query: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
E Q + + ++E+L TE E QQ+ +++E +T LKK L E +
Sbjct: 1145 -----EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1358 MKEELKEKKVE-ISSLSKQLTDLN---VQLQNSISLSEKEAA--------ISSLRKQYDE 1405
+E+++K + + L++QL L + EKE A + +++ +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1406 EKCELLDQVQDLSFKVDTLSK------EKISALE-QVDDWSNKFSEWKKKAQSRFTQHQN 1458
+K +L QVQ+L K + +K+ L+ +V+ + +E + KA +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
+LQ EL +E +K L++ +++N D L EME K +E+ S L
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNI 1378
Query: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH--KELVQKLQHFQELGEEK 1576
+L ++ + +E+L E K + QK+IE+ ++ +K + +L + K
Sbjct: 1379 QLSDSKKKLQDFAS-------TVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHV-----NLSVKSKEE----ELKALED 1627
+ +E ++ ++ L+NQ + + LE K+++ + + N+S K +E E +A E
Sbjct: 1430 NRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSE--LNTKL 1681
++ S A+ E +A++++ K L ++ME+ K++ K E S+ L T++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
+E + ++ LE++L++ E ++ R N+ A Q E D Q ++ EEK L
Sbjct: 1549 EEMKTQLEELEDELQATEDAKL------RLEVNMQALKGQFERDLQARDEQN-EEKRRQL 1601
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
QR L E E L+ + K+ +++ + + + + ++L+ D ++ G
Sbjct: 1602 QRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGR----- 1647
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EE K+ + AQ + + + +A + D++ T +E E + LE + +L
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASR------DEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 1862 CLV------RQKEVHRVEM-EELTSKYEKLQALQQMDGRNKPT-ELLEENTEEKSKSHLV 1913
L +Q ++ + E+ EEL S ALQ R + LEE EE+
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ----- 1756
Query: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
NMEA + + AE+ +L E QK+ + +Q+LE KE
Sbjct: 1757 -----GNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-----ESARQQLERQNKEL-- 1804
Query: 1974 EREEKIKQEQEDLELKHNSTLKQL---MREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
K+ + + ++ K ST+ L + + Q+ Q+ +E + K K ++++ L
Sbjct: 1805 --RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 2031 LESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
L+ E + + K+ AEK + + KR E + + + A R LQ +L+E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 186 bits (472), Expect = 2e-46
Identities = 256/1157 (22%), Positives = 514/1157 (44%), Gaps = 137/1157 (11%)
Query: 116 PPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
P + + E++ D L K + +R ++ E L K+S+L +LQ + +
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ-- 233
+ +++++ +R A+ +E ++ + + L+EE D + + + + Q + L +Q
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 234 -----RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
R + V + +LE + V + N S ++E+ S T L +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEE 1026
Query: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
++ +NL K K + + SE E ++ ++ QELEK+K + + Q+
Sbjct: 1027 EKAKNLTKL--------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-- 406
D + I +L+ M +A+ + ++ L ++EIAQ + +K++ + + +E
Sbjct: 1079 ADLQAQIAELK----MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
SERAA + EK + EA LK E+++ T++ T + QQEL +++
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEA---LKTELED---TLDST------ATQQELRAKREQE 1182
Query: 467 VDVMKKSSEEQI----AKLQKLHEKELARKEQELTKKLQ--TREREFQEQMKVALEKSQS 520
V V+KK+ +E+ A++Q++ +K A+ +ELT++L+ R + ++ K LEK +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 521 ----EYLKISQEKEQQE----SLALEELELQKKA-----ILTESENKLRDLQQEAETYRT 567
E + Q K++ E L + ELQ K E +K+ LQ E E+
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 568 RILELESSLEKSLQENKNQSKDL--AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
+ E E K ++ + S L L E+ + ++ + + + E SL+ Q D
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD- 1360
Query: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
E+++ KQ + + L + K+ L F + +E + E Q E
Sbjct: 1361 ---EEMEA-KQNLERHISTLNIQLSDSKKKLQD-----FASTVEALEEGKKR----FQKE 1407
Query: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN--HHQQQVDSIIKEH 743
+E+L+ + E A KLE+ + L+ + D + +L+ + N Q++ D ++ E
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 744 EVSIQRTEKALKDQINQLELLLKERD-------KHLKEHQAHVENLEADIKRSEGELQQA 796
+ D+ ++ E +E++ + L+E E LE K + E++
Sbjct: 1468 ----KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
+ D + +A E Q+ +++ +L +LE E + E K + +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-------LQATEDAKLRLEVNM 1576
Query: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
A K Q + +Q ++QN E ++++ YE++LED E++Q K+ +
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAAAAKKKL---- 1629
Query: 917 REGQKKEIEILTQK-LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK---K 972
EG K++E+ + +E++I L + + + K+ ++++E + E+ T K K
Sbjct: 1630 -EGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 973 KLLDQEAKLKKELEN-TALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
K EA L + E+ A E ++K EK+ A+ L + + + D RLE +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQ----------EIHEIQLQEKEQEVAELK 1077
E L E + + +S +K QQAE+L + +E Q+ E++ EL+
Sbjct: 1748 LEEELEE--EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 1078 QKI-LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL 1136
K+ + G K + I L+ + + + +++++ ++K A SL Q + KLK L
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
L+V+ + + E + K AE+ +V +L +L+ +EE Q + ++ K
Sbjct: 1863 --LQVEDERKMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
Query: 1197 KSLEDKSLEFKKLSEEL 1213
+ L++ + + + E+
Sbjct: 1912 RELDEATESNEAMGREV 1928
Score = 182 bits (462), Expect = 3e-45
Identities = 211/938 (22%), Positives = 423/938 (45%), Gaps = 112/938 (11%)
Query: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Q+ + EE Q+ + ++ EN++K ++ L EK LQ++ + + +E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 1337 KESCITQL---KKELSENINAVTLMKEELKEK----KVEISSLSKQLTDLNVQLQNSISL 1389
E +L K+EL E ++ + EE +++ + E +++Q+ DL QL+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 1390 SEKEAAISSLR--KQYDEEKCELL-DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
E+EAA L+ K E K + L D++ + + + LSKE+ E++ D + +E +
Sbjct: 968 -EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 1447 KKAQSRF---TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
+KA++ +H++ + EL+++L+ + K E ++ L+ + +++ L+ ++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKEL 1562
+ K ++ KKE L+ A + L+D I QK ++ + E+ + + Q+D++ +
Sbjct: 1087 ELKMQLAKKEEELQ-------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1563 VQKLQHFQ--ELGEEKDNRVKEAEEKI-LTLENQVYSMKAELETK--KKELEHVNLSVKS 1617
+ Q +LGEE + E E+ + T Q K E E KK L+ S ++
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1618 KEEELKALEDRLESESAAKLAELKR------------KAEQKIAAIKKQLLSQMEEKEEQ 1665
+ +E++ + E +L + KR + E A + ++L Q +++ E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1666 YKKGTESHLSELNTKLQERER-------EVHILEEKLKSVESSQSETL-IVPRSAKNVAA 1717
KK E+ + EL +K + ER +VH L+ +++SV +E + AK+VA+
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1718 YTEQEEADSQGCVQKTYEEKISVLQ--RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
+ Q + D+Q +Q+ +K++V R L E+ LQ + +E + + +
Sbjct: 1320 LSSQLQ-DTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHIST 1375
Query: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN-LENV 1834
I+L ++ K + S + L+E + K+ + Q+ EK + ++ +N L+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
DD+ L + LE+K ++ D L +K + +SKY + + + R
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--------SSKYADERDRAEAEARE 1487
Query: 1895 KPTELL------EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
K T+ L EE E K + L + ME DL K +GK +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEME----DLV-------SSKDDVGKNVHE 1536
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+K R L + ++E +K + ++ +E Q ED +L+ ++ L +F L +
Sbjct: 1537 LEKSKRAL----ETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAR 2066
+++ E ++ + E E EL E + L A+K + DLK + + + R
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETEL---EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 2067 EE------EMTAKVRDLQTQLEELQKK----YQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
EE ++ A+++D Q +LE+ + + E E+ + +M+LQ LA
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 2117 TLISDSKLKEQEFREQI-------HNLEDRLKKYEKNV 2147
+ L+++E E++ + L+D ++ E +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Score = 155 bits (391), Expect = 5e-37
Identities = 220/1047 (21%), Positives = 457/1047 (43%), Gaps = 129/1047 (12%)
Query: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+++ ++ EE+ + QQ A + +M + EQL+E R Q
Sbjct: 933 EMEARLEEEEDRGQQLQAERK---------KMAQQMLDLEEQLEEEEAAR---------Q 974
Query: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD---- 119
KLQL + E+ + E L L + DL ++ A + +
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 120 MDSEAEDLVGNSD-SLNKEQLI-QRLRRMERSLSSYRGKYSELVTAYQ--------MLQR 169
+ ++ E ++ + L KE+ Q L +++R L + E + Q L +
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 170 EKKKLQGILSQSQDKSLRR-------------IAELREELQMDQQA-------KKHLQEE 209
++++LQ L++ D+ ++ I++L+E+L ++ A K+ L EE
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 210 FDASLEEKDQYISVLQTQ----------VSLLKQRL----RNGPMNVDVLKP-----LPQ 250
+A E + + TQ V++LK+ L R+ V ++ + +
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 251 LEPQAEVFTKEE-NPESDGEPVVEDGTSVK-TLETLQQRVKRQENLLKRCKETIQSHKEQ 308
L Q E F + + N + + + + ++ + L L Q + E+ K+ + +Q + +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
C+ + L +++ + E+E + + + K I +D +L QL+ + ++ E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER------AAFEELEKALST 422
T+++++ + +++ QL + Q +E E K+ ER + +K L
Sbjct: 1335 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIA 479
T EA + K ++I+ + + EE+ + L++ +R++QE+ D++ ++
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-- 1447
Query: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALE 538
+L EK+ + +Q L ++ + E+ + E + E +S + +E+L A E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESS---LEKSLQENKNQSKDLAVHLE 595
ELE K + E E DL + + ELE S LE ++E K Q ++L L+
Sbjct: 1508 ELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 596 A-EKNKHNKEITVMVEKHKTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREK----- 648
A E K E+ + K + E + + +Q+ +LQ +Y+TE+E R++
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 649 -CEQEKETLLKDKEIIFQAHIEEMNE--KTLEKLDVK----QTELESLSSELSEVLKARH 701
+++ E LKD E+ + I+ E K L KL + Q ELE + E+
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
+ E++ L+ +++++L A +K ++ + + E S AL+D+ +L
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE--LAEELASSLSGRNALQDEKRRL 1741
Query: 762 ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
E + + ++ L+E Q ++E + ++++ + +Q S +L +S + E Q
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--LEKQ--NSEM 877
+L+ KL ++E V+++ K L+A Q+++ ++Q EKQ +
Sbjct: 1802 KELRSKLHEME----------GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
+QK K L ++ ++ED K EQ K+ EK N ++ + Q +E E +Q+++A
Sbjct: 1852 KQKDKKLKEIL-LQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 938 IHILNEEYETKFKNQEKKMEKVKQKAK 964
+ +E + +++ +K K +
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLR 1936
Score = 122 bits (305), Expect = 5e-27
Identities = 145/628 (23%), Positives = 293/628 (46%), Gaps = 97/628 (15%)
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+L+ Q+++++ KE +LQ +E ++ +N +KE E+K L + ++ +L+ + +
Sbjct: 851 LLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 1607 ---ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
E E + + + +K++EL+ + +E A+L E + + +Q + A +K++ QM + E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEME----ARLEEEEDRGQQ-LQAERKKMAQQMLDLE 963
Query: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
EQ L E Q+ + E E K+K +E E L++ ++
Sbjct: 964 EQ--------LEEEEAARQKLQLEKVTAEAKIKKLED---EILVM------------DDQ 1000
Query: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQYQERLI--- 1778
+ +K EE+IS L NL E+E+ + + + K E++ S E+R + +E+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 1779 -----KLEHAEAKQHED----QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK- 1828
KLE + HE Q+ I L+ +L +K ++ +A+ ++ KNN K
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1120
Query: 1829 QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888
+ LE D+Q+ L + E++ ++L L E + E+E+ Q L+
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL----EALKTELEDTLDSTATQQELR 1176
Query: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL------EFKLAGA--EREKQ 1940
R + +L++ +E+++SH Q + + AQ + +FK A A ++ KQ
Sbjct: 1177 AK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
L KE L +LR+L + +QE+E KK K++ + ++L+ K + +
Sbjct: 1235 TLEKENADLAGELRVLGQA-KQEVEHKKK--------KLEAQVQELQSKCSDGERA---- 1281
Query: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
+L K +L+ ++ E E + ++ L K +A L+ T + +
Sbjct: 1282 -RAELNDKVHKLQNEVESVTGMLNEAEGKAIK--------LAKDVASLSSQLQDTQELLQ 1332
Query: 2061 EILDAREE-EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
E + R++ ++ K+R L+ + LQ + +++E ++N L+ ++ +
Sbjct: 1333 E--ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------LERHISTLNIQL 1380
Query: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
SDSK K Q+F + LE+ K+++K +
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Score = 47.0 bits (110), Expect = 2e-04
Identities = 50/248 (20%), Positives = 113/248 (45%), Gaps = 26/248 (10%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNS--STPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
++ +++ E+++L + LA + + N+ R+ +R + E+L+E E G+ ++
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE-----EQGNMEA 1761
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
+ +++ E L E RS+++++ S+R+ L R + + + + +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATE---RSTAQKN---ESARQQLERQNKELRSKLHEMEGAV 1815
Query: 121 DSEAEDLVGNSDSLN---KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
S+ + + ++ +EQ+ Q R + + S + K +L ++ E+K +
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 178 LSQSQD-----KSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLL 231
Q++ K L+R + E EE Q ++ LQ E D + E + + +V+ L
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNAL 1931
Query: 232 KQRLRNGP 239
K +LR P
Sbjct: 1932 KSKLRGPP 1939
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 244 bits (624), Expect = 5e-64
Identities = 302/1261 (23%), Positives = 595/1261 (47%), Gaps = 180/1261 (14%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+++Q+LT ++ +R +K+ + + K+ Q Q+E + +E
Sbjct: 801 LARKAFAKRQQQLTA-MKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKED 859
Query: 541 ELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
ELQK K ++EN+L++L+Q+ +++ E ++ L++ LQ + ++ EAE
Sbjct: 860 ELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQA------ETELYAEAE-- 907
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
E+ V + K ELE + H+ +A E+ + QQ Q E +K+ ++ +E L ++
Sbjct: 908 ----EMRVRLAAKKQELEEILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 660 KEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
+ + +E++ E ++KL+ + ++ +++LS K R LEE +S L T+ +
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS---KERKLLEERISDLT--TNLAE 1017
Query: 719 QELEAK-MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK----ERDKHLK 773
+E +AK + + KN H+ S+I E EV +++ EK+ + ++ +L+ L+ + + +
Sbjct: 1018 EEEKAKNLTKLKNKHE----SMISELEVRLKKEEKS-RQELEKLKRKLEGDASDFHEQIA 1072
Query: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
+ QA + L+ + + E ELQ A A+LD + ++ ++ + E ++ LQ+ DL++
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE---DLDS 1129
Query: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN---SEMEQKVKSL------ 884
ER K E QK+D+ EL+A K +++D + Q ++ EQ+V L
Sbjct: 1130 ERAARNK----AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 885 -TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
T+ +E+++++ ++ Q + L E+ + + K + L ++ + + +L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 944 ---EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
E E K K E ++++++ K + E + +L D+ KL+ E+E+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSD-GERARAELNDKVHKLQNEVESVT----------- 1293
Query: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
ML A+ + ++ V+ L + ++ E L E R++LN +S ++L ++ LQ+
Sbjct: 1294 -GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQD 1350
Query: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK------EEGVKQ-DTTLNELQE 1113
QL E+ + L++ I + + K++ EEG K+ + L +
Sbjct: 1351 ----QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173
Q ++K+A + L + + +L+ L+ L VDL+ Q QLV E+ +RK +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--------QRQLVSN---LEKKQRKFDQ 1455
Query: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
L ++ K ++ + E + E K+L + EE A++ ++T +L+A+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE-ALEAKEELERTNKMLKAEME 1514
Query: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
+L+ SSK + + H K K AL E Q+ EE T
Sbjct: 1515 DLV---SSKDD-----VGKNVHELEKSKRAL----------ETQM----EEMKT------ 1546
Query: 1294 QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSENI 1352
QLEE E+++++ + L +AL+ + QA E+ E QL+++L E
Sbjct: 1547 ----QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY- 1601
Query: 1353 NAVTLMKEELKEKKVEISSLSKQLTDL-NVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
T +++E K++ + ++ K DL +++LQ ++ +E AI LRK
Sbjct: 1602 --ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK---------- 1649
Query: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
L ++ +E A D+ E +KKA+S +Q+Q +L +
Sbjct: 1650 -----LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL------EADLMQLQEDLAA 1698
Query: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531
E K Q +L KEEL ++ + ++D+K ++E + + LE EL+ + + +
Sbjct: 1699 AERARK--QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 1532 DHITQKTIEIESLNEVL----------KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581
D + + T + E L+ L ++ QQ + ++KEL KL + + K
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK----- 1811
Query: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
+ I LE ++ ++ ++E + +E + S+K K+++LK E L+ E K+AE
Sbjct: 1812 -FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVEDERKMAEQY 1868
Query: 1642 RKAEQKIAAIKKQLLSQMEEKEEQY------KKGTESHLSELNTKLQEREREVHILEEKL 1695
++ +K A KQL Q+EE EE+ ++ + L E + REV+ L+ KL
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 1696 K 1696
+
Sbjct: 1929 R 1929
Score = 204 bits (519), Expect = 8e-52
Identities = 267/1195 (22%), Positives = 524/1195 (43%), Gaps = 171/1195 (14%)
Query: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
K + + Q+ + ++M + +EL++ KE+ ++A E E +Q TEE + L E +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--KNLLQEQLQ 897
Query: 440 QIKTIEKTSEEERISL---QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
+ +EE R+ L +QEL +E++ M+ EE+ + Q+L + +Q L
Sbjct: 898 AETELYAEAEEMRVRLAAKKQEL----EEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 497 TKKLQTREREFQEQMKVALEK--SQSEYLKISQE---------KEQQESLALEELELQKK 545
+ Q E E Q K+ LEK ++++ K+ E K +E LEE
Sbjct: 954 DLEEQLEEEEAARQ-KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605
L E E K ++L + + + I ELE L+K ++++ + + L LE + + +++I
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 606 TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
+ + ++ LK Q L +++ Q + +L ++ Q+ L K +E+ +
Sbjct: 1072 ADL----QAQIAELKMQ--------LAKKEEELQAALARLDDEIAQKNNALKKIREL--E 1117
Query: 666 AHIEEM-----------NEKTLEKLDVKQTELESLSSELSEVL-------KARHKLEEEL 707
HI ++ N+ +K D+ + ELE+L +EL + L + R K E+E+
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEV 1176
Query: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
+VLK D+ + EA++ E + H Q V+ + ++ E +R + L LE +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENAD 1235
Query: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
L+ + +E K+ E ++Q+ +K + ++ +++ + ++ +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
L + E + I L K VA + +Q +D Q+L+Q+ +Q + K++ L +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQD-----------TQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKK------EIEILTQKLSAKEDSIHIL 941
S + ++E E + + + +Q+ + +KK +E L + + I L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
++YE K + K+EK K + ++ + L LD + +L LE +K+++F+
Sbjct: 1405 TQQYEEKAAAYD-KLEKTKNRLQQELDDLVVD-LDNQRQLVSNLE-------KKQRKFDQ 1455
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ E +S +D R E +E+ E K A L+E
Sbjct: 1456 LLAEEKNISSK-YADERDRAEAEAREK-------------------ETKALSLARALEEA 1495
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
E + +E E+ LK ++ K+++ K + L++ +T + E++ QL++
Sbjct: 1496 LEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSL--------KENTFLQEQLVELKMLAEEDKRK--- 1170
+ + + +L+ +++ L+ + L ++ LQ QL E + E+++++
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 1171 ----VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
+L LK + + S E++ K L + K EL D + E
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE---DARASRDEI 1671
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKV----KEALLIKTCTVSELEAQL---R 1279
AK NE K ++ + + Q K+A L K EL + L
Sbjct: 1672 FATAKENE------KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
L +E+ L Q +LEE++ +++M + + E L E ++ A + ES
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785
Query: 1340 CITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
QL+++ E + + M+ +K K K I++L ++ L Q++ EK+AA S
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKS 1843
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
L KQ D++ E+L QV+D + K+ + ++ E +K +R
Sbjct: 1844 L-KQKDKKLKEILLQVED---------ERKM---------AEQYKEQAEKGNAR------ 1878
Query: 1459 TVKELQIQLELKSKEAYEKDEQINL----LKEELDQQNKRFDCLKGEMEDDKSKM 1509
VK+L+ QLE EA E+ ++IN L+ ELD+ + + + E+ KSK+
Sbjct: 1879 -VKQLKRQLE----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 188 bits (477), Expect = 6e-47
Identities = 270/1194 (22%), Positives = 528/1194 (44%), Gaps = 158/1194 (13%)
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELEN-----------TALELSQKEKQFNAKMLEMAQ 1008
K AK Q+ K++ + +L N L+++++E++ AK
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------ 857
Query: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAEELQEIHE--I 1064
D + + + Q++ L E+ ++ +L + ++ +++L + E E E +
Sbjct: 858 ------EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
+L K+QE+ E+ ++ E+E+ ++ L+ E K + +L+EQL+++ A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 1125 LAQDETKLKAHLEKLEVDL-------NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
L ++ +A ++KLE ++ NK KE L+E++ +L E++ K LT K
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-K 1027
Query: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
LK E S+ S E K E E +KL +L ++ A L+A+ EL
Sbjct: 1028 LKNKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQIAELKM 1083
Query: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
+ K + + ++ + AL + ELE + L E+ ++ + +A
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKA-- 1137
Query: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
E Q + + ++E+L TE E QQ+ +++E +T LKK L E +
Sbjct: 1138 -----EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 1358 MKEELKEKKVE-ISSLSKQLTDLN---VQLQNSISLSEKEAA--------ISSLRKQYDE 1405
+E+++K + + L++QL L + EKE A + +++ +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1406 EKCELLDQVQDLSFKVDTLSK------EKISALE-QVDDWSNKFSEWKKKAQSRFTQHQN 1458
+K +L QVQ+L K + +K+ L+ +V+ + +E + KA +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
+LQ EL +E +K L++ +++N D L EME K +E+ S L
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNI 1371
Query: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH--KELVQKLQHFQELGEEK 1576
+L ++ + +E+L E K + QK+IE+ ++ +K + +L + K
Sbjct: 1372 QLSDSKKKLQDFAS-------TVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHV-----NLSVKSKEE----ELKALED 1627
+ +E ++ ++ L+NQ + + LE K+++ + + N+S K +E E +A E
Sbjct: 1423 NRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSE--LNTKL 1681
++ S A+ E +A++++ K L ++ME+ K++ K E S+ L T++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
+E + ++ LE++L++ E ++ R N+ A Q E D Q ++ EEK L
Sbjct: 1542 EEMKTQLEELEDELQATEDAKL------RLEVNMQALKGQFERDLQARDEQN-EEKRRQL 1594
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
QR L E E L+ + K+ +++ + + + + ++L+ D ++ G
Sbjct: 1595 QRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGR----- 1640
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EE K+ + AQ + + + +A + D++ T +E E + LE + +L
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASR------DEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 1862 CLV------RQKEVHRVEM-EELTSKYEKLQALQQMDGRNKPT-ELLEENTEEKSKSHLV 1913
L +Q ++ + E+ EEL S ALQ R + LEE EE+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ----- 1749
Query: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
NMEA + + AE+ +L E QK+ + +Q+LE KE
Sbjct: 1750 -----GNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-----ESARQQLERQNKEL-- 1797
Query: 1974 EREEKIKQEQEDLELKHNSTLKQL---MREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
K+ + + ++ K ST+ L + + Q+ Q+ +E + K K ++++ L
Sbjct: 1798 --RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 2031 LESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
L+ E + + K+ AEK + + KR E + + + A R LQ +L+E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 186 bits (472), Expect = 2e-46
Identities = 256/1157 (22%), Positives = 514/1157 (44%), Gaps = 137/1157 (11%)
Query: 116 PPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
P + + E++ D L K + +R ++ E L K+S+L +LQ + +
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ-- 233
+ +++++ +R A+ +E ++ + + L+EE D + + + + Q + L +Q
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 234 -----RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
R + V + +LE + V + N S ++E+ S T L +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEE 1019
Query: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
++ +NL K K + + SE E ++ ++ QELEK+K + + Q+
Sbjct: 1020 EKAKNLTKL--------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-- 406
D + I +L+ M +A+ + ++ L ++EIAQ + +K++ + + +E
Sbjct: 1072 ADLQAQIAELK----MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
SERAA + EK + EA LK E+++ T++ T + QQEL +++
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEA---LKTELED---TLDST------ATQQELRAKREQE 1175
Query: 467 VDVMKKSSEEQI----AKLQKLHEKELARKEQELTKKLQ--TREREFQEQMKVALEKSQS 520
V V+KK+ +E+ A++Q++ +K A+ +ELT++L+ R + ++ K LEK +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 521 ----EYLKISQEKEQQE----SLALEELELQKKA-----ILTESENKLRDLQQEAETYRT 567
E + Q K++ E L + ELQ K E +K+ LQ E E+
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 568 RILELESSLEKSLQENKNQSKDL--AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
+ E E K ++ + S L L E+ + ++ + + + E SL+ Q D
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD- 1353
Query: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
E+++ KQ + + L + K+ L F + +E + E Q E
Sbjct: 1354 ---EEMEA-KQNLERHISTLNIQLSDSKKKLQD-----FASTVEALEEGKKR----FQKE 1400
Query: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN--HHQQQVDSIIKEH 743
+E+L+ + E A KLE+ + L+ + D + +L+ + N Q++ D ++ E
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 744 EVSIQRTEKALKDQINQLELLLKERD-------KHLKEHQAHVENLEADIKRSEGELQQA 796
+ D+ ++ E +E++ + L+E E LE K + E++
Sbjct: 1461 ----KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
+ D + +A E Q+ +++ +L +LE E + E K + +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-------LQATEDAKLRLEVNM 1569
Query: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
A K Q + +Q ++QN E ++++ YE++LED E++Q K+ +
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAAAAKKKL---- 1622
Query: 917 REGQKKEIEILTQK-LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK---K 972
EG K++E+ + +E++I L + + + K+ ++++E + E+ T K K
Sbjct: 1623 -EGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 973 KLLDQEAKLKKELEN-TALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
K EA L + E+ A E ++K EK+ A+ L + + + D RLE +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQ----------EIHEIQLQEKEQEVAELK 1077
E L E + + +S +K QQAE+L + +E Q+ E++ EL+
Sbjct: 1741 LEEELEE--EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 1078 QKI-LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL 1136
K+ + G K + I L+ + + + +++++ ++K A SL Q + KLK L
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
L+V+ + + E + K AE+ +V +L +L+ +EE Q + ++ K
Sbjct: 1856 --LQVEDERKMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 1197 KSLEDKSLEFKKLSEEL 1213
+ L++ + + + E+
Sbjct: 1905 RELDEATESNEAMGREV 1921
Score = 182 bits (462), Expect = 3e-45
Identities = 211/938 (22%), Positives = 423/938 (45%), Gaps = 112/938 (11%)
Query: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Q+ + EE Q+ + ++ EN++K ++ L EK LQ++ + + +E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 1337 KESCITQL---KKELSENINAVTLMKEELKEK----KVEISSLSKQLTDLNVQLQNSISL 1389
E +L K+EL E ++ + EE +++ + E +++Q+ DL QL+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 960
Query: 1390 SEKEAAISSLR--KQYDEEKCELL-DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
E+EAA L+ K E K + L D++ + + + LSKE+ E++ D + +E +
Sbjct: 961 -EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 1447 KKAQSRF---TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
+KA++ +H++ + EL+++L+ + K E ++ L+ + +++ L+ ++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKEL 1562
+ K ++ KKE L+ A + L+D I QK ++ + E+ + + Q+D++ +
Sbjct: 1080 ELKMQLAKKEEELQ-------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 1563 VQKLQHFQ--ELGEEKDNRVKEAEEKI-LTLENQVYSMKAELETK--KKELEHVNLSVKS 1617
+ Q +LGEE + E E+ + T Q K E E KK L+ S ++
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 1618 KEEELKALEDRLESESAAKLAELKR------------KAEQKIAAIKKQLLSQMEEKEEQ 1665
+ +E++ + E +L + KR + E A + ++L Q +++ E
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1666 YKKGTESHLSELNTKLQERER-------EVHILEEKLKSVESSQSETL-IVPRSAKNVAA 1717
KK E+ + EL +K + ER +VH L+ +++SV +E + AK+VA+
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1718 YTEQEEADSQGCVQKTYEEKISVLQ--RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
+ Q + D+Q +Q+ +K++V R L E+ LQ + +E + + +
Sbjct: 1313 LSSQLQ-DTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHIST 1368
Query: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN-LENV 1834
I+L ++ K + S + L+E + K+ + Q+ EK + ++ +N L+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
DD+ L + LE+K ++ D L +K + +SKY + + + R
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--------SSKYADERDRAEAEARE 1480
Query: 1895 KPTELL------EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
K T+ L EE E K + L + ME DL K +GK +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEME----DLV-------SSKDDVGKNVHE 1529
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+K R L + ++E +K + ++ +E Q ED +L+ ++ L +F L +
Sbjct: 1530 LEKSKRAL----ETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAR 2066
+++ E ++ + E E EL E + L A+K + DLK + + + R
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETEL---EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 2067 EE------EMTAKVRDLQTQLEELQKK----YQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
EE ++ A+++D Q +LE+ + + E E+ + +M+LQ LA
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 2117 TLISDSKLKEQEFREQI-------HNLEDRLKKYEKNV 2147
+ L+++E E++ + L+D ++ E +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Score = 155 bits (391), Expect = 5e-37
Identities = 220/1047 (21%), Positives = 457/1047 (43%), Gaps = 129/1047 (12%)
Query: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+++ ++ EE+ + QQ A + +M + EQL+E R Q
Sbjct: 926 EMEARLEEEEDRGQQLQAERK---------KMAQQMLDLEEQLEEEEAAR---------Q 967
Query: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD---- 119
KLQL + E+ + E L L + DL ++ A + +
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 120 MDSEAEDLVGNSD-SLNKEQLI-QRLRRMERSLSSYRGKYSELVTAYQ--------MLQR 169
+ ++ E ++ + L KE+ Q L +++R L + E + Q L +
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 170 EKKKLQGILSQSQDKSLRR-------------IAELREELQMDQQA-------KKHLQEE 209
++++LQ L++ D+ ++ I++L+E+L ++ A K+ L EE
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 210 FDASLEEKDQYISVLQTQ----------VSLLKQRL----RNGPMNVDVLKP-----LPQ 250
+A E + + TQ V++LK+ L R+ V ++ + +
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 251 LEPQAEVFTKEE-NPESDGEPVVEDGTSVK-TLETLQQRVKRQENLLKRCKETIQSHKEQ 308
L Q E F + + N + + + + ++ + L L Q + E+ K+ + +Q + +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
C+ + L +++ + E+E + + + K I +D +L QL+ + ++ E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER------AAFEELEKALST 422
T+++++ + +++ QL + Q +E E K+ ER + +K L
Sbjct: 1328 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIA 479
T EA + K ++I+ + + EE+ + L++ +R++QE+ D++ ++
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-- 1440
Query: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALE 538
+L EK+ + +Q L ++ + E+ + E + E +S + +E+L A E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESS---LEKSLQENKNQSKDLAVHLE 595
ELE K + E E DL + + ELE S LE ++E K Q ++L L+
Sbjct: 1501 ELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 596 A-EKNKHNKEITVMVEKHKTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREK----- 648
A E K E+ + K + E + + +Q+ +LQ +Y+TE+E R++
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 649 -CEQEKETLLKDKEIIFQAHIEEMNE--KTLEKLDVK----QTELESLSSELSEVLKARH 701
+++ E LKD E+ + I+ E K L KL + Q ELE + E+
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
+ E++ L+ +++++L A +K ++ + + E S AL+D+ +L
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE--LAEELASSLSGRNALQDEKRRL 1734
Query: 762 ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
E + + ++ L+E Q ++E + ++++ + +Q S +L +S + E Q
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--LEKQ--NSEM 877
+L+ KL ++E V+++ K L+A Q+++ ++Q EKQ +
Sbjct: 1795 KELRSKLHEME----------GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
+QK K L ++ ++ED K EQ K+ EK N ++ + Q +E E +Q+++A
Sbjct: 1845 KQKDKKLKEIL-LQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 938 IHILNEEYETKFKNQEKKMEKVKQKAK 964
+ +E + +++ +K K +
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLR 1929
Score = 122 bits (305), Expect = 5e-27
Identities = 145/628 (23%), Positives = 293/628 (46%), Gaps = 97/628 (15%)
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+L+ Q+++++ KE +LQ +E ++ +N +KE E+K L + ++ +L+ + +
Sbjct: 844 LLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 1607 ---ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
E E + + + +K++EL+ + +E A+L E + + +Q + A +K++ QM + E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEME----ARLEEEEDRGQQ-LQAERKKMAQQMLDLE 956
Query: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
EQ L E Q+ + E E K+K +E E L++ ++
Sbjct: 957 EQ--------LEEEEAARQKLQLEKVTAEAKIKKLED---EILVM------------DDQ 993
Query: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQYQERLI--- 1778
+ +K EE+IS L NL E+E+ + + + K E++ S E+R + +E+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 1779 -----KLEHAEAKQHED----QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK- 1828
KLE + HE Q+ I L+ +L +K ++ +A+ ++ KNN K
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1113
Query: 1829 QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888
+ LE D+Q+ L + E++ ++L L E + E+E+ Q L+
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL----EALKTELEDTLDSTATQQELR 1169
Query: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL------EFKLAGA--EREKQ 1940
R + +L++ +E+++SH Q + + AQ + +FK A A ++ KQ
Sbjct: 1170 AK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
L KE L +LR+L + +QE+E KK K++ + ++L+ K + +
Sbjct: 1228 TLEKENADLAGELRVLGQA-KQEVEHKKK--------KLEAQVQELQSKCSDGERA---- 1274
Query: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
+L K +L+ ++ E E + ++ L K +A L+ T + +
Sbjct: 1275 -RAELNDKVHKLQNEVESVTGMLNEAEGKAIK--------LAKDVASLSSQLQDTQELLQ 1325
Query: 2061 EILDAREE-EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
E + R++ ++ K+R L+ + LQ + +++E ++N L+ ++ +
Sbjct: 1326 E--ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------LERHISTLNIQL 1373
Query: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
SDSK K Q+F + LE+ K+++K +
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Score = 47.0 bits (110), Expect = 2e-04
Identities = 50/248 (20%), Positives = 113/248 (45%), Gaps = 26/248 (10%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNS--STPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
++ +++ E+++L + LA + + N+ R+ +R + E+L+E E G+ ++
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE-----EQGNMEA 1754
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
+ +++ E L E RS+++++ S+R+ L R + + + + +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATE---RSTAQKN---ESARQQLERQNKELRSKLHEMEGAV 1808
Query: 121 DSEAEDLVGNSDSLN---KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
S+ + + ++ +EQ+ Q R + + S + K +L ++ E+K +
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 178 LSQSQD-----KSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLL 231
Q++ K L+R + E EE Q ++ LQ E D + E + + +V+ L
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNAL 1924
Query: 232 KQRLRNGP 239
K +LR P
Sbjct: 1925 KSKLRGPP 1932
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 241 bits (615), Expect = 6e-63
Identities = 377/1839 (20%), Positives = 777/1839 (42%), Gaps = 235/1839 (12%)
Query: 330 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE--TKRQMHETLEMKEEEIAQL 387
L + LH+A+ + + QL+D I+ +++ G + K+ + E L+ + +
Sbjct: 12 LSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKN 71
Query: 388 RSR--------IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
R Q +G EL + K + + + E+ K++AE+
Sbjct: 72 RKHPSSPECLVSAQKVLEGSEL--ELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAV 129
Query: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
+K + E+ ++L ++L Q+ SS +EL+ +
Sbjct: 130 ILKFV--LDHEDGLNLNEDLENFLQKAPVPSTCSS---------TFPEELSPPSHQ---- 174
Query: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
RE F E KVA S + +L S + L + ++++ E RD +
Sbjct: 175 -AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRD-E 232
Query: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL--- 616
E E R L E + ++ + + L +A KE+ + +K+++
Sbjct: 233 LELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRL 292
Query: 617 -ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE----M 671
E+LK QD L TEK Q+ + K+ + E+ + K +E F +H+++ +
Sbjct: 293 HETLKQCQD-LKTEKSQMDR--------KINQLSEENGDLSFKLRE--FASHLQQLQDAL 341
Query: 672 NEKTLEKLDVKQTELE---SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
NE T E Q LE L ELS L+ + LEE+ +L+ + ++++ L D
Sbjct: 342 NELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNP 401
Query: 729 KNHHQQQVDSI-----IKEHEVSIQRTEKALKDQINQLEL--------LLKERDKHLKEH 775
+ + + +K+ ++ L+ ++ LE LL ER H +E
Sbjct: 402 PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG-HFEEE 460
Query: 776 QAHVENLEADIKRSEGELQQASAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
+ + +L D++ S L QA +L+ Q++ + Q + +L L + + E
Sbjct: 461 KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
L +Q E +AQ + L + Q L Q+E+ +S ++QK + L +V E K E
Sbjct: 521 LAGLKQQAKEKQAQ---LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE-KQEA 576
Query: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK----EDSIHILNE---EYET 947
++ Q E+ L+ R+ K++E L ++ +AK + + + NE +T
Sbjct: 577 TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
Query: 948 KFKNQEKKMEKVKQKAKEMQ---ETLKKKLLD---QEAKLKKELENTALELSQKEK--QF 999
+++ ++ +K +E+Q ET +++ + Q A+L+ +L + + ++KE+ Q
Sbjct: 637 SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
Query: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
++ E QA + LE ++ ++L E +R ++++ + + Q E +
Sbjct: 697 KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEE-QQRCISELKAETRSLVEQHKRERK 755
Query: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
E+ E + K E A L+Q E E + +E L E Q T +E ++ +K+
Sbjct: 756 ELEEERAGRKGLE-ARLQQLGEAHQAETEVLRRE---LAEAMAAQHTAESECEQLVKE-- 809
Query: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
+ A E+ E + + QEQL+ LK E+ ++++ E K+
Sbjct: 810 ------------VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
+ SH + L+ + ELA ++ AL + + E +
Sbjct: 858 GIE--------SHSE---------LQISRQQNELA---ELHANLARALQQVQEKE---VR 894
Query: 1240 SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF------- 1292
+ K LS + T+K V+ LE +R+ E+Q T +
Sbjct: 895 AQKLADDLSTLQEKMAATSK----------EVARLETLVRKAGEQQETASRELVKEPARA 944
Query: 1293 --QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
+Q E++ Q S +A ++++ E E + E + A E + Q ++E +
Sbjct: 945 GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG---QQQEERGQ 1001
Query: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
V + +E + +++ +L ++LQN +L+E+ ++L++ E
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQN--ALNEQRVEFATLQEALAHALTEK 1059
Query: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470
+ Q+L+ K+ L +I LE++ + E K + E + E
Sbjct: 1060 EGKDQELA-KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118
Query: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET---ELKSQTARI 1527
+ +++ L+++ +Q ++ D L+ +E +++ +++S LET +L+ + +
Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178
Query: 1528 MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI 1587
+ + E+ + ++++++ +D E ++ ++ E K++ + EE++
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAED----EWKAQVARGRQEAERKNSLISSLEEEV 1234
Query: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647
L QV E E + KEL+ + ++ K ++L+ L++E+A+ A +A ++
Sbjct: 1235 SILNRQV----LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA----RAAER 1286
Query: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE---REVHILEEKLKSVESSQSE 1704
+A+++++ S EE E+Q + +E+ EL ++ + E +E+ +EK E + S
Sbjct: 1287 SSALREEVQSLREEAEKQ-RVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALST 1345
Query: 1705 TLIVPRSAKNV------AAYTEQEEADSQGCVQKTYEEKISV--------------LQRN 1744
+ S + + A + Q+ Q +K + E++ QR
Sbjct: 1346 LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRE 1405
Query: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH-------- 1796
L E L Q+V E+E T + Y E+L L+ A E+ +G
Sbjct: 1406 LGELIPLRQKVA-EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQF 1464
Query: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE-LTCQILEQK 1855
L+ EL++ +KY +E A+ L V + Q T +E E +T + K
Sbjct: 1465 LEVELDQAREKY--------VQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK 1516
Query: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQP 1915
+K L+ +++ + E ++LT++ E+L+ Q+ + K E L + + ++ VQ
Sbjct: 1517 VKVLE-----ERQRFQEERQKLTAQVEQLEVFQR--EQTKQVEELSKKLADSDQASKVQQ 1569
Query: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL---RMLRKEHQQELEILKKEYD 1972
+ L ++AQ + +++E Q+L ++ LQ L + ++ ++E K YD
Sbjct: 1570 QKLKAVQAQGGE-------SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYD 1622
Query: 1973 --QEREEKIKQEQEDLE--LKHNSTLKQLMREFNTQLAQ---KEQELEMTIKETINKAQE 2025
+++ ++++++ LE K N L+ +L Q K +E E T + + +
Sbjct: 1623 AKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS 1682
Query: 2026 VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064
+EA++ +H ++ + L K D LK + + LD
Sbjct: 1683 LEAQV--AHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
Score = 210 bits (534), Expect = 1e-53
Identities = 331/1621 (20%), Positives = 671/1621 (41%), Gaps = 268/1621 (16%)
Query: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
K Q+ +++ ++ K E + Q LQ +L S++ + L + A+L +E
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365
Query: 196 LQMDQQAKKHLQEE---FDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252
L Q KK L+E+ L + ++++S LQ K + + ++ LK
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK------ 419
Query: 253 PQAEVFTKEENPESDGEPVVEDGTSVKT-LETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
+ + + T ++ +E L+ +QE L + + K+Q +
Sbjct: 420 -------------QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS 466
Query: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKT----KLITQLRDAKNLIEQLEQDKGMVIA 367
L ++ ++ L + +ELE+ H A T L ++L I+Q +Q+ +
Sbjct: 467 LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ 526
Query: 368 ETKR---QMHETLEMKEEEIAQLRSRIKQMTT----QGEELREQKEKSERAAFEELEKAL 420
+ K Q+ +TL+ +E+ LR +++Q+++ + ++L+E EK E + ++
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586
Query: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480
+ A++ E + R+ A + +Q++ +EK + LQQ+L +V + + S++ + +
Sbjct: 587 TAAEEREASLRERDAAL-KQLEALEKEKAAKLEILQQQL-----QVANEARDSAQTSVTQ 640
Query: 481 LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Q+ + EL+RK +EL ++T +++++ + + EL
Sbjct: 641 AQR-EKAELSRKVEELQACVET-----------------------ARQEQHEAQAQVAEL 676
Query: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
ELQ LR QQ+A T + R+ + + L++ LQ K K LE EK +
Sbjct: 677 ELQ-----------LRSEQQKA-TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR 724
Query: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQV--LKQQYQTEMEKLREKCEQEKETLLK 658
++L+ QQ + K + L +Q++ E ++L E+ K
Sbjct: 725 --------------AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG---- 766
Query: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
+A ++++ E Q E E L EL+E + A+H E E L + +
Sbjct: 767 -----LEARLQQLGE-------AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814
Query: 719 QELEAKMDEQKNH---HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775
+ E E+ + Q+Q+ ++ +E E + Q ++A KE+ ++ H
Sbjct: 815 ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA------------KEKVAGIESH 862
Query: 776 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE--EQLAQLQQKLLDLET 833
E I R + EL + A L ++ Q ++ +A + + L+ LQ+K+
Sbjct: 863 S------ELQISRQQNELAELHANLA--RALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
Query: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ-LEKQNSEMEQKVKSLTQVYESKL 892
E L V + Q++ EL + D + LE+Q ++ Q E +
Sbjct: 915 EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREA 974
Query: 893 EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI---LNEEYETKF 949
E E E+ + L+E + + R Q++E+ LTQ+ + + + E E +
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 950 KN--QEKKMEKVKQKAKEMQETLKKKLLDQE-AKLK-------KELENTALELSQKEKQF 999
+N E+++E + +K+ DQE AKL+ KELE + Q ++Q
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Query: 1000 NAKMLEMA-----QANSAGISDA-----------VSRLETN---QKEQIESLTE------ 1034
K E A Q+ +AG ++ VS+LE Q+EQ +SL
Sbjct: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
Query: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
R E + + + +L ++A+EL + L ++E+A + K+ ++E ++
Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGH-SQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213
Query: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ 1154
++E ++++ ++ L+E++ + V + +LK + + KS K L+
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK---RLVMAESEKSQK----LE 1266
Query: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF-------K 1207
E+L L+ + + +E +S L+ EE QSL+ EK + E+ E +
Sbjct: 1267 ERLRLLQAETASNSARAAERSSALR---EEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
+L +EL + +K +AL + + + T A++S + +H +++ +
Sbjct: 1324 ELGQELKAWQEKFFQKEQAL------STLQLEHTSTQALVSELLPAKHLCQQLQAE---Q 1374
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327
+L Q + L +A +L E L+ ++ + ++
Sbjct: 1375 AAAEKRHREELEQSKQAAGGLRAELLRAQRELGE--------------LIPLRQKVAEQE 1420
Query: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
QQ +EK S QL S A L+ EE + E ++L +Q ++ +
Sbjct: 1421 RTAQQLRAEKASYAEQL----SMLKKAHGLLAEENRGLG-ERANLGRQFLEVELDQAREK 1475
Query: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
+ E A + + E + E ++L K+ LE+ +F E ++
Sbjct: 1476 YVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE----RQRFQEERQ 1531
Query: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
K ++ Q + +E Q+E SK+ + D+ + +++L K GE + +
Sbjct: 1532 KLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL----KAVQAQGGESQQEAQ 1587
Query: 1508 KMEKKESNLETEL--KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
+++ + + L+ +L K Q A +L+ E K + K +++EL ++
Sbjct: 1588 RLQAQLNELQAQLSQKEQAAEHYKLQ-------------MEKAKTHYDAKKQQNQELQEQ 1634
Query: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE---EL 1622
L+ ++L +K+N+ ++AE E EL+ L K E+ L
Sbjct: 1635 LRSLEQL--QKENK----------------ELRAEAERLGHELQQAGLKTKEAEQTCRHL 1676
Query: 1623 KALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQ 1682
A LE++ A +L+ + ++A ++ +E Q K + + L+ +
Sbjct: 1677 TAQVRSLEAQVAHADQQLRDLGKFQVAT------DALKSREPQAKPQLDLSIDSLDLSCE 1730
Query: 1683 E 1683
E
Sbjct: 1731 E 1731
Score = 206 bits (523), Expect = 3e-52
Identities = 364/1696 (21%), Positives = 682/1696 (40%), Gaps = 275/1696 (16%)
Query: 611 KHKTELESLKHQQDALWTEKLQVLKQQ-----YQTEMEKLREKCEQEKETLLKDKEIIFQ 665
KH + E L Q L +L++ K + T K EQ + + + +I +
Sbjct: 73 KHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILK 132
Query: 666 --------AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
++ E E L+K V T + ELS H+ + E+ L+ Q K+
Sbjct: 133 FVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSP---PSHQAKREIRFLELQ--KV 187
Query: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN---QLELLLKERDKHLKE 774
+ + I++ + ++R +K L D+ + +LEL L E K L E
Sbjct: 188 ASSSSGN-NFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTE 246
Query: 775 HQAHVENLEADIKRSE--GELQQASA-KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
A + ++ I R E Q AS + + + T E L Q Q DL
Sbjct: 247 KDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ----DL 302
Query: 832 ETERILLTKQVAEVEAQKKDVC---TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
+TE+ + +++ ++ + D+ E +H Q+QD + +L +++S+ Q+
Sbjct: 303 KTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLE----- 357
Query: 889 ESKLEDGNKEQEQTKQILVEKE-NMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
KQ +EKE + LQ ++ +++ EIL KLS E+ + L +
Sbjct: 358 --------------KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDN--- 400
Query: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
++K + + + L+ + L QEA L + + Q +MLE
Sbjct: 401 ----------PPQEKGEVLGDVLQLETLKQEA--------ATLAANNTQLQARVEMLETE 442
Query: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQ 1067
+ A +K+Q+ SL +L IS L+Q EEL++ +
Sbjct: 443 RGQQEAKLLAERGHFEEEKQQLSSLIT----DLQSSIS----NLSQAKEELEQASQAHGA 494
Query: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
+VA L E+T L +QD L L++Q K+K A + Q
Sbjct: 495 RLTAQVASL--------------TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 540
Query: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
+ + L L+ SLK+ +EQ +LK +AE+ + + +L T EE ++
Sbjct: 541 QQEQASQGLRHQVEQLSSSLKQ----KEQ--QLKEVAEKQEATRQDHAQQLATAAEEREA 594
Query: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS-KTNAI 1246
+ + K LE L +E A +L+I ++ + EA+ + +++ + + A
Sbjct: 595 SLRERDAALKQLE-------ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE 647
Query: 1247 LSR-ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ 1305
LSR + Q ++ V+ELE QLR +++ T Q QL+E Q
Sbjct: 648 LSRKVEELQACVETARQEQHEAQAQVAELELQLRS-EQQKATEKERVAQEKDQLQE---Q 703
Query: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
++++K ESL K +L++E A E++ CI++LK E + ++EL+E+
Sbjct: 704 LQALK---ESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
Query: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL-------------D 1412
+ L +L L Q + +E A + + E +CE L
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 1413 QVQDLSF------KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQ 1466
Q ++ + ++ TL +E A +++ + K + + ++ + ++ QN + EL
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
Query: 1467 LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET---ELKSQ 1523
L ++ EK+ + L ++L ++ E+ ++ + K ET EL +
Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE 940
Query: 1524 TAR-----------------------IMELEDHITQKTIEIESLNEVL-KNYNQQKDIEH 1559
AR + +E Q E+E L L ++ QQ++
Sbjct: 941 PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG 1000
Query: 1560 KELVQKLQHFQELGEEKDNRVKE---AEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616
++ + + QE G + + E E + L+N + + E T ++ L H +
Sbjct: 1001 QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 1617 SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT------ 1670
K++EL L LE+ +L EL++ KQL Q+ +KE+++ G+
Sbjct: 1061 GKDQELAKLRG-LEAAQIKELEELRQTV--------KQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 1671 --------------ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
+ +S+L + Q+++ + LE L++ +S++E + +
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171
Query: 1717 AYTEQEEADSQGCVQKTYEE----KISVLQRNLTEKEKLLQ----RVGQEKEETVSSHFE 1768
QE SQ + E + V + E E Q R E++ ++ S E
Sbjct: 1172 EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE 1231
Query: 1769 MRCQYQERLIKLEHAEAKQHEDQSMI-GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
R + + E+K+ + M ++LEE+ + ++ E N+ +A
Sbjct: 1232 EEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER--------LRLLQAETASNSARA 1283
Query: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK-YEKLQA 1886
+ + ++VQ +E E E +EL S R +E+ + E++ K ++K QA
Sbjct: 1284 AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ-ELKAWQEKFFQKEQA 1342
Query: 1887 LQQMDGRNKPTELL-----------------EENTEEKSKSHLVQPKLLSN------MEA 1923
L + + T+ L + E++ + L Q K + + A
Sbjct: 1343 LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRA 1402
Query: 1924 QHN-----DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK 1978
Q L K+A ER Q+L E + L ML+K H L E ++ E+
Sbjct: 1403 QRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG-----LLAEENRGLGER 1457
Query: 1979 IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET 2038
++ LE++ + ++ ++E A E L +E + A+E+E + +
Sbjct: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKV 1517
Query: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL---EELQKKYQQKLEQE 2095
L ++ +++ K TA+ E L+ + E T +V +L +L ++ K QQKL+
Sbjct: 1518 KVLEERQRFQEERQKLTAQ--VEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
Query: 2096 ENPGNDN--------VTIMELQTQLAQKTTLISDSKL--------------KEQEFREQI 2133
+ G ++ + ELQ QL+QK KL + QE +EQ+
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 2134 HNLEDRLKKYEKNVYA 2149
+LE +L+K K + A
Sbjct: 1636 RSLE-QLQKENKELRA 1650
Score = 202 bits (513), Expect = 4e-51
Identities = 319/1647 (19%), Positives = 678/1647 (41%), Gaps = 171/1647 (10%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++LK+++++E+ + + + N T ++ + +++D E
Sbjct: 217 RRLKKQLADERSNRDEL--ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 63 QK----LQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPS 118
K L+ + S+ +K+ + K + R ++ S DL F
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
+A + + S ++ +++ ++E+ LS+ L ++LQ + +L+ L
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 179 SQSQDKSLRRIAE-LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
SQ QD + E L + LQ++ L++E Q LQ +V +L+
Sbjct: 395 SQLQDNPPQEKGEVLGDVLQLET-----LKQEAATLAANNTQ----LQARVEMLE--TER 443
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
G +L E + + + + LQ + +
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLS-------------------SLITDLQSSISNLSQAKEE 484
Query: 298 CKETIQSHKEQCTL----LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
++ Q+H + T LTSE L + ++ QEL +K ++ +L L+ +
Sbjct: 485 LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQ 544
Query: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF 413
+ L + + K++ + E+ E++ A + +Q+ T EE RE + AA
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE-REASLRERDAAL 603
Query: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473
++L EA K KA E ++ + + E R S Q +++ ++E ++ +K
Sbjct: 604 KQL-----------EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKV 652
Query: 474 SEEQ-IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ-SEYLKISQEKEQ 531
E Q + + + E + EL +L++ +++ E+ +VA EK Q E L+ +E +
Sbjct: 653 EELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712
Query: 532 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
+LEE + + L E + + +L+ E + ++E K L+E + K L
Sbjct: 713 VTKGSLEEEKRRAADALEEQQRCISELKAETRS----LVEQHKRERKELEEERAGRKGLE 768
Query: 592 VHLEAEKNKHNKEITV--------MVEKHKTELESLKHQQD-ALWTEKLQVLKQQ----- 637
L+ H E V M +H E E + ++ A W E+ + +Q+
Sbjct: 769 ARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 638 --YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695
+Q ++ L+E+CE+ ++ L + KE + A IE +E + + +Q EL L + L+
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKV--AGIESHSELQISR---QQNELAELHANLAR 883
Query: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
L+ + E L D +++++ A E + ++ S + ++ +
Sbjct: 884 ALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPAR 943
Query: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Q E L +++ + QA ++ +E + ++ EL++ A L Q Q E+
Sbjct: 944 AGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ---QEERG 1000
Query: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--LEKQ 873
E ++A+L Q+ + + L AE+E + ++ E +Q+ + EK+
Sbjct: 1001 QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 874 NSEME-QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 932
+ E K++ L +LE+ + +Q K+ L +KE G + E T+
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS-GSGAQSEAAGRTEPTG 1119
Query: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL 992
K +++ + + K+E+ QK +E ++L++ L + + + ++ALE
Sbjct: 1120 PKLEAL-----------RAEVSKLEQQCQKQQEQADSLERSL--EAERASRAERDSALET 1166
Query: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
Q + + A+ L +Q+ A ++ T ++ ++ E W+ ++
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE------------WKAQVA 1214
Query: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
+ +E + + + + E+EV+ L +++L E +E+ + + E+ K + L LQ
Sbjct: 1215 RGRQEAERKNSL-ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ 1273
Query: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
+ SA A+ + L+ ++ L + K + L+++L AEE +++
Sbjct: 1274 AETASNSARA---AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
Query: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKT 1232
K ++ +L+ H S ++L + L K L ++L + +A E +
Sbjct: 1331 AWQEKFFQKEQALSTLQLEH-TSTQALVSELLPAKHLCQQLQAE--------QAAAEKRH 1381
Query: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL--NI 1290
E + S + + + Q + L+ V+E E +QL E+ + +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGE----LIPLRQKVAEQERTAQQLRAEKASYAEQL 1437
Query: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
S + H L +EN+ +A++ E E Q Q+ A+ + T+
Sbjct: 1438 SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR------- 1490
Query: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
L E + E S +++L + + + + + + R+++ EE+ +L
Sbjct: 1491 -----------LAEVQREAQSTARELEVMTAKYEGA------KVKVLEERQRFQEERQKL 1533
Query: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470
QV+ L + +E+ +QV++ S K ++ + ++ + Q +K +Q Q
Sbjct: 1534 TAQVEQL----EVFQREQ---TKQVEELSKKLADSDQASKVQ----QQKLKAVQAQGGES 1582
Query: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
+EA Q+N L+ +L Q+ + + K +ME K+ + K+ EL+ Q + +L
Sbjct: 1583 QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ-NQELQEQLRSLEQL 1641
Query: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
+ + E E L L QQ ++ KE Q +H + +V A++++ L
Sbjct: 1642 QKENKELRAEAERLGHEL----QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Query: 1591 ENQVYSMKAELETKKKELEHVNLSVKS 1617
+ A + + ++LS+ S
Sbjct: 1698 GKFQVATDALKSREPQAKPQLDLSIDS 1724
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 241 bits (614), Expect = 8e-63
Identities = 386/1768 (21%), Positives = 764/1768 (43%), Gaps = 269/1768 (15%)
Query: 174 LQGILSQSQ-DKSLRRIAELREELQMDQQAK----KHLQEEFDASLEEKDQYISVLQTQV 228
LQ +L +++ +K + + E+ DQQ++ K E+F +E + QY + + ++
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKF--KVESEQQYFEI-EKRL 61
Query: 229 SLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESD-----------------GEP 270
S ++RL N L+ L +L Q + T E+N E + E
Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALT-EKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSH---KEQCTLLTSEKEALQEQLDERL 327
E ++T E L Q ++ +KR E ++ K + L E +A + R
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
+ LE+ K+L ++ T L T+L+ + + L ++KG I E K LE K+EE+++L
Sbjct: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC----NLENKKEEVSRL 236
Query: 388 RSRIKQMTTQGEELREQKE---------KSERAAFEE-----------LEKALSTAQKTE 427
++ + T E L++ E K ++A+ EE L +A
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487
EA+ E++ + K + E ++Q L V+Q D M+K E+I +L+K E
Sbjct: 297 EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEK--EL 353
Query: 488 ELARKEQELTKK----LQTREREFQEQMKVALEKSQSEYLKISQ----EKEQQESLALEE 539
E A TK+ L E A+ K +K+++ E Q+ L LE+
Sbjct: 354 ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEK 413
Query: 540 LELQK-----KAILTESENKLRDLQQEAETY---RTRILELESSLEKSLQENKNQSKDLA 591
LE ++ I+ E E K L+++ E Y + + L LE++++E +
Sbjct: 414 LENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ------- 466
Query: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
L+ + +K NK+ +V+ E+ +E +++ L QQ + + +L E
Sbjct: 467 -RLQEDTDKANKQSSVL-ERDNRRMEI-----------QVKDLSQQIRVLLMELE---EA 510
Query: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
+++D+E + A I +E + L V +E L + +L A +L E +
Sbjct: 511 RGNHVIRDEE-VSSADISSSSEVISQHL-VSYRNIEELQQQNQRLLVALRELGETREREE 568
Query: 712 DQTDKMK-QELEAKMD----------EQKNHHQQQVDSIIKEHE----VSIQRTEKALKD 756
+T K EL+ K++ + + H Q VDSI+++ + + Q T A+
Sbjct: 569 QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPL 628
Query: 757 QINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL----DVFQSYQSATH 811
+ L ++ L K Q + S E +A A L ++F++Y+
Sbjct: 629 HASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST-EAIEAKAALKQLQEIFENYKKEKA 687
Query: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---MQ 868
E K EQL +LQ+++ DL ++ ++ Q+ + + + ++ ++ ++ L Q
Sbjct: 688 ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQ 747
Query: 869 QLEKQNSEMEQKVKSLTQ----------VYESKLEDGNKEQEQTK----QILVEKENMIL 914
+L + EQ + ++TQ V E + E+ KE+E K ++ ++E+++
Sbjct: 748 KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 915 QMREGQKKEIE-------ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
+ R GQ + IL + + + + E+ E + + +KK+E ++ +
Sbjct: 808 EQR-GQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
Query: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
L +LLD + +L E T L L+ KE +L+ AQ A + +S +E
Sbjct: 867 RNLDVQLLDTKRQLDTE---TNLHLNTKE------LLKNAQKEIATLKQHLSNMEVQVAS 917
Query: 1028 QIESLT----EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Q T ++ +++D++S QL++ E++V +LK+++
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVS-------------------QLRQTEEQVNDLKERLKTS 958
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
E+ +T L+E K+ E+++ ++ + A+ +T+L+ L ++E
Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE---VRLKESAEFQTQLEKKLMEVE--- 1012
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
KE LQ+ + + E ++++SEL L + E Q + ++++ +L ++
Sbjct: 1013 ----KEKQELQD---DKRRAIESMEQQLSELKKTLSSVQNEVQ---EALQRASTALSNEQ 1062
Query: 1204 LEFKKLSEELAIQLDICCK-KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ E+ I ++ K + E +L A E + + + + + S H + T K +
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LL C S E + L + + E+ E Q + + IE L + A
Sbjct: 1123 QLL--ECKAS--------WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
KEG S E +Q +++ E + + ++E+ E + E++ + V+
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQ--EQILEILRFIR-REKEIAETRFEVAQVESLRYRQRVE 1229
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
L L E + ++++ R++ + + + Q ++L K +T++ V + +
Sbjct: 1230 LLER-ELQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMN--------VVMETNKML 1279
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQ---LELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
E K++ + Q Q V++L++ L+ + E EK + K+ L++ KR+
Sbjct: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1500 GEMEDDKSKMEKKE-SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
+ + + +E L +E + T RI +L + I + EI N L N
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN-------- 1391
Query: 1559 HKELVQKL-QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
++ L+Q L + ++ EK+ K+ + KI+ ++ +V ++ +++ + K+
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI--------TQVKKIGRRYKT 1443
Query: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
+ EELKA +D++ SA + EQ ++ + Q L + + E K ES + L
Sbjct: 1444 QYEELKAQQDKVMETSAQSSGD---HQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
Query: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
L E+E E L+E+ ++S S R +++ T QEE Q +K EEK
Sbjct: 1501 QKTLSEKETEARNLQEQTVQLQSELS------RLRQDLQDRTTQEEQLRQQITEK--EEK 1552
Query: 1738 --------------ISVLQRNLT-EKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIK 1779
++ ++ LT E E+L QR G Q+K+E ++ QY+ R+ +
Sbjct: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISR 1612
Query: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKK 1807
LE E ++H+++ + ++E +E + K
Sbjct: 1613 LER-ELREHQERHL--EQRDEPQEPSNK 1637
Score = 216 bits (550), Expect = 2e-55
Identities = 370/1698 (21%), Positives = 742/1698 (43%), Gaps = 202/1698 (11%)
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL--HEKELAR 491
+ E+++ K+++ E+ Q E+ +K + K SE+Q +++K H +E
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRH-EKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK----EQQESLALEELELQKKAI 547
E + L+ + Q+K EK++ L+I+Q++ + Q + EELE +K+ +
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKE--LEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
Query: 548 LTESENKLRDLQQEAETYRTRILELESSL----EKSLQENKNQSKDLAVHLEAEKNKHNK 603
+ +E ++L+ E + +L+ S E L+ ++ Q+ D++V ++ + K
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
Query: 604 EITVMVEKH-KTELESLKHQQDALWTEK-LQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661
E+ TEL++ + AL EK ++L+ + E +K +E+ LK
Sbjct: 188 ELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN 247
Query: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721
Q H+E++ L KL + + S+ + L A KL D ++ EL
Sbjct: 248 EHLQKHVEDL----LTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 722 EAKMDEQKNHHQQ--QVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV 779
++E ++ + + I++H + +++++ +Q+E + E+ L++ +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSK-------DQMEKEMLEKIGRLEKELENA 356
Query: 780 ENLEADIKR-----SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD-LET 833
+L + KR SE EL S + T+ Y + Q LL+ LE
Sbjct: 357 NDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLEN 416
Query: 834 ERI--LLTKQVAEVEAQK---KDVCTELDAHKIQVQDLMQQLEKQNSEME--QKVKSLTQ 886
+RI L + V EVEA+ K E + + V L +LE+ E++ Q+
Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
Query: 887 VYESKLEDGNKEQE-QTKQILVEKENMILQMREGQKKEI----EILTQKLSAKEDSI--H 939
S LE N+ E Q K + + +++++ E + + E+ + +S+ + I H
Sbjct: 477 KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH 536
Query: 940 ILNEEYETKFKNQEKKM-----EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
+++ + + Q +++ E + + +E QET K+ + + KL+ L T LE +
Sbjct: 537 LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESAL--TELEQLR 594
Query: 995 KEKQFNAKMLE------------MAQANSAGIS------DAVSRLETNQKEQ-------- 1028
K +Q ++++ ++Q I D VS T ++
Sbjct: 595 KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTP 654
Query: 1029 -----IESLTEVHRRE-LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082
IES + + L + I+E ++AE ++I QL++ +++V +L+ +
Sbjct: 655 APVPVIESTEAIEAKAALKQLQEIFENYKKEKAEN-EKIQNEQLEKLQEQVTDLRSQNTK 713
Query: 1083 FGCEKEEMNKEITWLKE--EGVKQD-TTLNELQEQL----KQKSAHVNSLAQDETKLKAH 1135
+ + +K L++ EG +++ T+L+E ++L +++ +N++ QD
Sbjct: 714 ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEK 773
Query: 1136 LEKLEVDLNKSLKENTFLQEQLVELKMLAEE---DKRKVSELTSKLKTTD--------EE 1184
L EV KE L+ V L E ++R + L + L+T E
Sbjct: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
Query: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEE---LAIQLDICCKKTEALLEAKTNELINISSS 1241
Q L S EK + + + E+ L LD+ T+ L+ +TN +N
Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893
Query: 1242 KTNA---ILSRISHCQHRTTKVKEALLIKTCT--------VSELEAQLRQLTEEQNTLNI 1290
NA I + H + +V +T V +L +QLRQ E+ N L
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
+ +T +E+ + + S++ ESL EK+ ++ N + E TQL+K+L E
Sbjct: 954 RLKTSTSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
Query: 1351 NINAVTLMKEELKE-KKVEISSLSKQLTDLNVQL---QNSISLSEKEAAISSLRKQYDEE 1406
V K+EL++ K+ I S+ +QL++L L QN + + + A+ + +Q
Sbjct: 1011 ----VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR 1066
Query: 1407 KCE----LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE 1462
C+ + + Q+ + L + AL+ + +K + ++ + + ++ + E
Sbjct: 1067 DCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
Query: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME--DDKSKMEKKES------ 1514
+ E + + ++ + E+L++QN+ L ++E DK KE
Sbjct: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNR---LLHDQIEKLSDKVVASVKEGVQGPLN 1183
Query: 1515 -NLETELKSQTA-----RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
+L E KSQ R + E I + E+ + + Y Q+ ++ +EL Q+LQ
Sbjct: 1184 VSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL--RYRQRVELLEREL-QELQD 1240
Query: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK---KELEHVNLSVKSKEEELKAL 1625
EK + + L + +M +ET K +E E + ++ + +++ L
Sbjct: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
Query: 1626 E-DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684
E D L + A AEL K+ A +K+LL EE +++K + +S+ E
Sbjct: 1301 ELDILPLQEAN--AELSEKSGMLQA--EKKLL---EEDVKRWKARNQHLVSQQKDPDTEE 1353
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
R+ +L EK + Q T + R +A + ++Q +Q E+ L +
Sbjct: 1354 YRK--LLSEKEVHTKRIQQLTEEIGRLKAEIAR-SNASLTNNQNLIQSLKED----LNKV 1406
Query: 1745 LTEKEKLLQRVG------QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
TEKE + + + QEK +T++ ++ +Y K ++ E K +D+ M Q
Sbjct: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRY-----KTQYEELKAQQDKVMETSAQ 1461
Query: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKE 1858
+ + + S+ Q +++ + ++K +LE+ +++QKTL EKE + L+++ +
Sbjct: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEARNLQEQTVQ 1520
Query: 1859 LDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK-SHLVQPKL 1917
L S L R ++ ++++ T++ E+L+ QQ+ + + T + KSK +HL K
Sbjct: 1521 LQSELSRLRQ----DLQDRTTQEEQLR--QQITEKEEKTR--KAIVAAKSKIAHLAGVK- 1571
Query: 1918 LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL--QKDLRMLRKEHQ----QELEILKKEY 1971
+ ++ +L+ + +++K +L I L Q + R+ R E + QE + +++
Sbjct: 1572 -DQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDE 1630
Query: 1972 DQEREEKIKQEQEDLELK 1989
QE K+ ++Q + LK
Sbjct: 1631 PQEPSNKVPEQQRQITLK 1648
Score = 211 bits (536), Expect = 8e-54
Identities = 352/1693 (20%), Positives = 709/1693 (41%), Gaps = 250/1693 (14%)
Query: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
LQQ E RT + +L S++ L++ D ++ K +H K V E+ E+E
Sbjct: 5 LQQVLE--RTELNKLPKSVQNKLEKFL---ADQQSEIDGLKGRHEK-FKVESEQQYFEIE 58
Query: 618 S-LKHQQDALWTEKLQVLKQQYQTEMEKLREKC----EQEKET-LLKDKEIIFQAHIEEM 671
L H Q+ L E + Q + E+EKL + E+ KE + +D+ I Q+
Sbjct: 59 KRLSHSQERLVNETREC--QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
Query: 672 NEKT-LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
E+ EK D+ +T E LS EL + + +L E+L +++ K EL+ K+DE
Sbjct: 117 KEELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDE--- 168
Query: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
++ +VS++ EK L+ + ELL + E + + L A +
Sbjct: 169 ---------LQASDVSVKYREKRLEQE---KELLHSQNTWLNTELKTKTDELLALGREKG 216
Query: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
E+ + L+ + S EQ + LQ+ + DL T+ +Q A +E +
Sbjct: 217 NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH 276
Query: 851 DVCTELDAHKIQVQDLMQQL----EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL 906
+ EL+AH I++ +L + E +++E+ + V+ L ++ + E Q+ ++
Sbjct: 277 N---ELNAH-IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
Query: 907 VEKENMILQMREG---QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
K+ M +M E +KE+E LSA + IL+EE + K+ +
Sbjct: 333 QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
Query: 964 KEMQETLKKKLLDQEAKLKKELENTA----LELSQKEKQFNAKMLEMAQANSAGISDAVS 1019
++ E + Q+ L ++LEN L+ KE + A +L+ + AV+
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
L ++ ++ + + +E D K N+Q+ L+ + + E +V +L Q+
Sbjct: 453 SLSVKLEQAMKEIQRL--QEDTD-------KANKQSSVLERDN----RRMEIQVKDLSQQ 499
Query: 1080 ILLFGCEKEEMNKEITWLKEEGVKQD-TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
I + E EE EE D ++ +E+ Q ++ L Q +L L +
Sbjct: 500 IRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 1139 LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
L + +E T K++EL KL++ E + L+ S + +
Sbjct: 560 LGETREREEQETT----------------SSKITELQLKLESALTELEQLRKSRQHQMQL 603
Query: 1199 LED----KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS------------- 1241
++ + + LS+ + + + + + A T + + S +
Sbjct: 604 VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663
Query: 1242 ---KTNAILSRISHCQHRTTKVK-EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
+ A L ++ K K E I+ + +L+ Q+ L + ++ A+
Sbjct: 664 EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASK 723
Query: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
+ E ++ ++ + +I SL + L Q+Q + +TQ + +E + +
Sbjct: 724 RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT----MTQDLRGANEKLAVAEV 779
Query: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
E LK++K + +L+++ + Q L+E+ L L +Q +
Sbjct: 780 RAENLKKEKEML-----KLSEVRLSQQRESLLAEQRGQNLLLTN---------LQTIQGI 825
Query: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
+ +T +K+++S+ Q++ ++ S KKK ++ Q + L +QL L +K +
Sbjct: 826 LERSETETKQRLSS--QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQL-LDTKRQLDT 882
Query: 1478 DEQINL-LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
+ ++L KE L K LK + SN+E ++ SQ++ Q
Sbjct: 883 ETNLHLNTKELLKNAQKEIATLKQHL-----------SNMEVQVASQSS----------Q 921
Query: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596
+T + + N+ +D++ +LV +L+ +E + R+K + + + V S
Sbjct: 922 RTGKGQPSNK--------EDVD--DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
Query: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656
++ L +K+ E V +++ + +E + +LE KL E++ K +Q++ K++ +
Sbjct: 972 LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK----KLMEVE-KEKQELQDDKRRAI 1026
Query: 1657 SQMEEKEEQYKKGTESHLSELNTKLQ--------EREREVHILEEKLKSVESSQS-ETLI 1707
ME++ + KK S +E+ LQ E++ E+ +VE+ E +
Sbjct: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
Query: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE-KEKLLQRVGQEKEETVSSH 1766
+ +A A +E+ V++ EE + L E K +R K+E S
Sbjct: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV--SK 1144
Query: 1767 FEMRCQYQERLIKLEHAEAKQHED-------QSMIGHLQEELEEKNKKYSLI--VAQHVE 1817
RC+ E+ +L H + ++ D + + G L L E+ K I + + +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
+E K+ E F+ Q ++LE++++EL L ++E +V + +
Sbjct: 1205 RE--------KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTM 1256
Query: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER 1937
E ++ + M+ + ++L E E + L M+A+ LE + +
Sbjct: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQD-------LQQMQAKVRKLELDILPLQE 1309
Query: 1938 EKQKLGKEIVRLQKDLRMLR------KEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991
+L ++ LQ + ++L K Q L +K+ D E K+ E+E H
Sbjct: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE----VHT 1365
Query: 1992 STLKQLMREFNTQLAQ---------KEQELEMTIKETINKAQ--------EVEAELLESH 2034
++QL E A+ Q L ++KE +NK + +++A++++
Sbjct: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ 1425
Query: 2035 QE-ETNQLLKKI------------AEKDDDLKRTAKR----------YEEILDARE--EE 2069
++ +T +KKI A++D ++ +A+ +E+ + +E +
Sbjct: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
Query: 2070 MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF 2129
K + L++Q+E LQK +K + N V +LQ++L++ + D +E++
Sbjct: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTV---QLQSELSRLRQDLQDRTTQEEQL 1542
Query: 2130 REQIHNLEDRLKK 2142
R+QI E++ +K
Sbjct: 1543 RQQITEKEEKTRK 1555
Score = 189 bits (480), Expect = 3e-47
Identities = 332/1558 (21%), Positives = 688/1558 (44%), Gaps = 191/1558 (12%)
Query: 119 DMDSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQ-------- 168
++++E DL+ ++ L++E L + ++R+ L EL LQ
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
Query: 169 REKK-KLQGILSQSQDKSLRRIAELR-EELQMDQQAKKHLQEEFDASLEEKDQYISVLQT 226
REK+ + + L SQ+ L + + +EL + K + E +LE K + +S L+
Sbjct: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
Query: 227 QVSLLKQRLRNGPMNV-DVLKPLPQLEPQA----EVFTKEENPE---SDGEPVVEDGTSV 278
Q++ LK + +V D+L L + + Q E F E N S+ D +
Sbjct: 239 QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
Query: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL----QELEKIK 334
K+ E L + V+ LLK E ++ ++ + K+ +++++ E++ +ELE
Sbjct: 299 KSNE-LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
Query: 335 DLHMAEKTK-------LITQLRDAKNLIEQLEQDKGMVIAETKRQMHET-----LEMKEE 382
DL A K K + + + ++ + GM + E ET LE E
Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP-GMKLTELYNAYVETQDQLLLEKLEN 416
Query: 383 EIAQ--LRSRIKQMTTQGEELREQKEKSERAAFEELEKAL-STAQKTEEARRKLKAEMDE 439
+ L +K++ + L+ Q+E+ ERA +KA+ S + K E+A ++++ ++
Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERA-----QKAVASLSVKLEQAMKEIQRLQED 471
Query: 440 QIKTIEKTSEEERISLQQE-----LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
K +++S ER + + E LS+ + ++ ++++ + + +++ +++ +
Sbjct: 472 TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
Query: 495 ELTKKLQTRER--EFQEQ---MKVALEKSQSEYLKISQEKEQQESLA--LEELELQKKAI 547
+++ L + E Q+Q + VAL + L ++E+E+QE+ + + EL+L+ ++
Sbjct: 532 VISQHLVSYRNIEELQQQNQRLLVALRE-----LGETREREEQETTSSKITELQLKLESA 586
Query: 548 LTESENKLRDLQ----------QEAETYRTRILELE--------SSLEK----SLQENKN 585
LTE E + Q ++ + YR + + SSL+ S + +
Sbjct: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
Query: 586 QSKDLAVH-----------LEAEKN-KHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633
S+ ++ +EA+ K +EI +K K E E ++++Q EKLQ
Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ----LEKLQE 702
Query: 634 LKQQYQTEMEKLREKCE--QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
+++ K+ + + ++ +L+D ++ I ++E+ +KL + E + +
Sbjct: 703 QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN-QKLTATTQKQEQIIN 761
Query: 692 ELSEVLKARHK-----------LEEELSVLKDQTDKMKQELEAKMDEQKNHHQ-----QQ 735
+++ L+ ++ L++E +LK ++ Q+ E+ + EQ+ + Q
Sbjct: 762 TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
Query: 736 VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQ 795
+ I++ E T++ L QI +LE + K L+ VE + + +L
Sbjct: 822 IQGILERSETE---TKQRLSSQIEKLEHEISHLKKKLENE---VEQRHTLTRNLDVQLLD 875
Query: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ-VAEVEAQKK---- 850
+LD + T E K ++++A L+Q L ++E + + Q + + K
Sbjct: 876 TKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD 935
Query: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
D+ ++L + QV DL ++L+ S +EQ +T + ES NKE++ T+++ ++
Sbjct: 936 DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL----NKEKQVTEEV---RK 988
Query: 911 NMILQMREG-------QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
N+ ++++E +KK +E+ +K ++D + E E + +K + V+ +
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI-ESMEQQLSELKKTLSSVQNEV 1047
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA-GISDAVSRLE 1022
+E + L +++ + E + + + K ML A + + VS++
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM- 1106
Query: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI----HEIQLQEK--EQEVAEL 1076
+ ++ +E T+ +L + + WE++ +E+ + +++ Q + ++ +L
Sbjct: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
Query: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN--SLAQDET-KLK 1133
K++ E + ++ L EEG Q+ L L+ ++K +AQ E+ + +
Sbjct: 1167 SDKVVASVKEGVQGPLNVS-LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYR 1225
Query: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193
+E LE +L + L+++ + + V++ ++ + T + E + L+ E
Sbjct: 1226 QRVELLERELQE-LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 1194 KSNKSLEDKSLEFKKLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISH 1252
+ + L+ + +KL +LDI ++ A L K+ L + +
Sbjct: 1285 RLEQDLQQMQAKVRKL------ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 1253 CQHRTTKVKEALLIK-TCTVSELEA---QLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
QH ++ K+ + +SE E +++QLTEE L ++ L +N I+S
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 1309 MKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368
+K D+ + TEKE +QK+ + EK ITQ+KK + EELK ++ +
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK-IGRRYKT---QYEELKAQQDK 1454
Query: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
+ S Q + + +S+ E + +L + + K L QV++L + E
Sbjct: 1455 VMETSAQSS--GDHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEA 1511
Query: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQ-----HQNTVKELQIQ---LELKSKEAY--EKD 1478
+ EQ ++ S ++ Q R TQ Q T KE + + + KSK A+
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK 1571
Query: 1479 EQINLLKEELDQQNKRFDCLKGEMEDD----KSKMEKKESNLETELKSQTARIMELED 1532
+Q+ EEL Q+N D K E++ KS+ E + S LE EL+ R +E D
Sbjct: 1572 DQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Score = 70.5 bits (171), Expect = 2e-11
Identities = 83/408 (20%), Positives = 180/408 (44%), Gaps = 67/408 (16%)
Query: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL-----------QGILSQSQDKS 185
+Q+ ++R++E + + +EL MLQ EKK L Q ++SQ +D
Sbjct: 1291 QQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD 1350
Query: 186 LRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVL 245
+L E ++ + + L EE I L+ +++ L N + L
Sbjct: 1351 TEEYRKLLSEKEVHTKRIQQLTEE-----------IGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 246 KPLPQLEPQAEVFTKEENPESD-GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS 304
K E +V T++E + D +++ VKT+ +VK+ K E +++
Sbjct: 1400 K-----EDLNKVRTEKETIQKDLDAKIIDIQEKVKTI----TQVKKIGRRYKTQYEELKA 1450
Query: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKD-LHMAEKTKLITQLRDAKNLIEQLEQDKG 363
+++ +++ ++ +QE++++K+ L+ AE T+ + ++ +E L++
Sbjct: 1451 QQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAE-----TKSKSLESQVENLQKTLS 1505
Query: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
E + +T+++ + E+++LR ++ TTQ E+LR+Q + E E+ KA+ A
Sbjct: 1506 EKETEARNLQEQTVQL-QSELSRLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAA 1560
Query: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
+ K +++++ + E + + +D K + +I L+
Sbjct: 1561 KS----------------KIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS 1604
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
+E ++R E+EL RE QE+ ++ Q K+ +++ Q
Sbjct: 1605 QYEGRISRLEREL--------REHQERHLEQRDEPQEPSNKVPEQQRQ 1644
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 238 bits (608), Expect = 4e-62
Identities = 396/1809 (21%), Positives = 779/1809 (43%), Gaps = 296/1809 (16%)
Query: 529 KEQQESLALEEL-ELQKKA--ILTESENKLRDLQQEAETYRTR-ILELESSLEKSLQEN- 583
K + E+L E+L + KK ++ +++++ +L++E E R++ + E + K+L E
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERL 78
Query: 584 ------KNQSKDLAVHLEAEKNKHNKEI----TVMVEKHKTELESLKHQQDALWTEKLQV 633
K +++ + L+ E K +E+ T M + HK ELE Q + ++++
Sbjct: 79 DALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHK-ELE----QSHINYVKEIEN 133
Query: 634 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 693
LK E+ +R K ++K L K E +E E+L + +++
Sbjct: 134 LKN----ELMAVRSKYSEDKANLQKQLEEAMNTQLE-----LSEQLKFQNNSEDNVKKLQ 184
Query: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 753
E+ K R EE++ L+ Q L+A DE+K Q+ +II+ + Q+ +
Sbjct: 185 EEIEKIRPGFEEQILYLQKQ-------LDATTDEKKET-VTQLQNIIEANSQHYQKNINS 236
Query: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA-KLDVFQSYQSATHE 812
L++++ QL+ + +E K L + +EA K E E+ + + K ++ + +++
Sbjct: 237 LQEELLQLKAIHQEEVKEL------MCQIEASAKEHEAEINKLNELKENLVKQCEASEKN 290
Query: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQ-VQDLMQQLE 871
K YE +L L++ + + Q+ + Q+ ++ K++ ++D +++LE
Sbjct: 291 IQKKYECELENLRKATSNANQDN-----QICSILLQENTFVEQVVNEKVKHLEDTLKELE 345
Query: 872 KQNSEMEQKVKSLTQVYESKLE-DGNKEQEQ---TKQILVEKENMILQMREGQKKEIEIL 927
Q+S ++ +V + + + KLE D +++ ++ L K N +L +E Q IE L
Sbjct: 346 SQHSILKDEVTYMNNL-KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKL 404
Query: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987
+L+ LN+++ V+Q +E+Q L +Q K EL
Sbjct: 405 KSELAG-------LNKQF----------CYTVEQHNREVQS-----LKEQHQKEISELNE 442
Query: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
T L S+KEK M E+ G+ + L+ ++E I ++ L +++ I
Sbjct: 443 TFLSDSEKEKL--TLMFEIQ-----GLKEQCENLQQEKQEAI-----LNYESLREIMEIL 490
Query: 1048 EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK---Q 1104
+ +L + A ++ + E Q++ +V EL+QK+ EK+ + + + L+ E K Q
Sbjct: 491 QTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 550
Query: 1105 DTTLNELQEQLK----QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKE-NTFLQ----- 1154
+ EL+ +K + ++ SL+Q +T LK +LE +N +E + F+
Sbjct: 551 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLK----ELEGKINSLTEEKDDFINKLKNS 606
Query: 1155 -EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED----KSLEFKKL 1209
E++ E ++R + EL K++ T + L+ + LE+ K +KL
Sbjct: 607 HEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL 666
Query: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
E+L +Q+ + + E +L A+ L ++K ++ ++S KE +++K
Sbjct: 667 -EKLMVQMKVLSEDKE-VLSAEVKSLYE-ENNKLSSEKKQLSRDLEVFLSQKEDVILKE- 722
Query: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSMKADIESLVTEKEA--- 1322
+++LE +L+ + EEQ+ LN + Q + Q+ K M +++ EK+
Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV 782
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
LQ G + + EK + Q +++ E + ++EE + E+ SL + V
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842
Query: 1383 LQNSIS--LSEKEAAISSLRKQYDE------EKCELLDQVQDLSFKVDTLSKEKIS---- 1430
L+ + SEKEA S L + + E LL QV+++S T SK +I
Sbjct: 843 LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS---QTCSKSEIHNEKE 899
Query: 1431 ------------ALEQVDDWSNK-----FSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473
LEQ + + + K+ S ++VKEL+ ++E KE
Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKE 959
Query: 1474 AYEKDEQINLL-------KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
EK+E+IN + K+ELD K +K E+E +S+ ++ +++ ++
Sbjct: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQG---- 1015
Query: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
ES +L Y +Q ++L EK+ R E +
Sbjct: 1016 --------------AESYKNLLLEYEKQS--------------EQLDVEKE-RANNFEHR 1046
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK-RKAE 1645
I L Q+ + + ET + S E+L A + L+S AKL E++ + +
Sbjct: 1047 IEDLTRQLRNSTLQCET-----------INSDNEDLLARIETLQSN--AKLLEVQILEVQ 1093
Query: 1646 QKIAAIKKQLLSQMEEKEEQYKK--GTESHLSELNTKLQEREREVHILEEKLKSVESSQS 1703
+ A + K+L ++ +KE++ K+ T + L EL +LQ+ ++++ ++L+ V+
Sbjct: 1094 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQ 1153
Query: 1704 ETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL---TEKEKLLQRVGQEKE 1760
+T ++ +A Y + +Q K KI L++ + +K++ LQ +
Sbjct: 1154 QTTLM---NMEIADYERLMKELNQKLTNK--NNKIEDLEQEIKIQKQKQETLQEEITSLQ 1208
Query: 1761 ETVSSHFEMRCQYQERLIKL--EHAEAKQHEDQSMI--GHLQEELEEKNKKYSLIVAQHV 1816
+V + E + ++ L+K E A++KQ E +I L+ ELE ++ + Q
Sbjct: 1209 SSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLA 1268
Query: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL-DSCLVRQKEVHRVEME 1875
E K+ I + ++ + ++ + T +Q++ L + C + E V E
Sbjct: 1269 EITSEKHKIH---------EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSE 1319
Query: 1876 ELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935
+ K L+Q +NK E ++ + HL E + L+ KL +
Sbjct: 1320 FESYKVRVHNVLKQQ--KNKSMSQAETEGAKQEREHL---------EMLIDQLKIKLQDS 1368
Query: 1936 EREKQKLGKEIVRLQKDLRMLRKEHQQEL-EILKKEYD-QEREEKIKQEQEDLELKHNST 1993
+ Q E+ LQ + L + H + L E + KE + +E+ I+ E ++ +H T
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428
Query: 1994 LKQLMRE-------FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET-------N 2039
+ QL + F Q+ ++E T++ + ++EA+L + E T
Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ 1488
Query: 2040 QLLKKIAEKDD------DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093
Q LK + E+ + D+ + E ++ + E + LE+L + KLE
Sbjct: 1489 QSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLE 1548
Query: 2094 QEENPGNDNVTIMELQTQLAQKTT-------LISDSKLKEQEFREQIHNLEDRLKKYEKN 2146
+ T EL +L+ T L+ +++ EQI L+ +++ E+N
Sbjct: 1549 PP--LWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN 1606
Query: 2147 VYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMM---GRETKTMAKVITTVLK 2203
EYL+ VL +++ G E + + VI T+L+
Sbjct: 1607 QEREK-------------------SAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQ 1647
Query: 2204 FPDDQTQKI 2212
++ K+
Sbjct: 1648 LSPEEKGKL 1656
Score = 238 bits (607), Expect = 5e-62
Identities = 384/1736 (22%), Positives = 776/1736 (44%), Gaps = 245/1736 (14%)
Query: 404 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTI---EKTSEEERISLQQELS 460
QK KS E+ + L + TE +KA + E++ + + +E++ +SL++E
Sbjct: 42 QKAKSRCTELEKEIEELRSKPVTEGTGDIIKA-LTERLDALLLEKAETEQQCLSLKKENI 100
Query: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
++KQEV E+ + K+ H KEL + K+++ + E +A+ S
Sbjct: 101 KMKQEV--------EDSVTKMGDAH-KELEQSHINYVKEIENLKNEL-----MAVRSKYS 146
Query: 521 EYLKISQEKEQQESLALEELELQKKA-ILTESENKLRDLQQEAETYR----TRILELESS 575
E K + +K+ +E++ + LEL ++ SE+ ++ LQ+E E R +IL L+
Sbjct: 147 ED-KANLQKQLEEAMNTQ-LELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204
Query: 576 LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK 635
L+ + E K L +EA + K I + E+ +L+++ ++ +++
Sbjct: 205 LDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE-LLQLKAIHQEEVKELMCQIEASA 263
Query: 636 QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695
++++ E+ KL E KE L+K E + +I++ E LE L K T + +++
Sbjct: 264 KEHEAEINKLNEL----KENLVKQCE-ASEKNIQKKYECELENLR-KATSNANQDNQICS 317
Query: 696 VL-------------KARH------KLEEELSVLKDQTD-----KMKQELEAKMDEQKNH 731
+L K +H +LE + S+LKD+ K+K E++A+ + +
Sbjct: 318 ILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFF 377
Query: 732 HQQQVDSIIKEHEVSIQRTEK--ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 789
H+++ D K +E+ + + E+ ++ ++L L K+ +++H V++L+ ++
Sbjct: 378 HERE-DLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436
Query: 790 EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK----LLDLETERILLTKQVAEV 845
EL + L + + + + +EQ LQQ+ +L+ E+ R ++ E+
Sbjct: 437 ISELNETF--LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
Query: 846 EAQKKDVCTELDAHKIQ----VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901
+ E ++ K Q V +L Q+L +E + ++++ ++L+ N++
Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV-----NRLQGENEKLLS 549
Query: 902 TKQILVEKENMILQMREGQKKEIEILTQK---LSAKEDSIHILNEE---YETKFKNQEKK 955
++++ E EN I ++E + L+Q+ L E I+ L EE + K KN ++
Sbjct: 550 QQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEE 609
Query: 956 MEKVKQKAKEMQETLKK--KLLDQEAKLKKELENT------ALELSQKEKQFNAKMLEMA 1007
M+ +K + + + + K ++Q + ELE LE + KEK N + LE
Sbjct: 610 MDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKL 669
Query: 1008 QANSAGISDAVSRLE-------------TNQKEQIESLTEVHRRELNDV-----ISIWEK 1049
+S+ L +++K+Q+ EV + DV I+ EK
Sbjct: 670 MVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEK 729
Query: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD--TT 1107
KL EE ++ +L E EQ V +L K L+G K EM E++ E+ ++D
Sbjct: 730 KLQLMVEEQDNLN--KLLENEQ-VQKLFVKTQLYGFLK-EMGSEVS---EDSEEKDVVNV 782
Query: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ-EQLVELKMLAEE 1166
L + E L + + +LA + LEK E+ K L+E + +Q E+L L E+
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEK-EI---KCLQEESVVQCEELKSLLRDYEQ 838
Query: 1167 DK----RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
+K +++ E+ S+ + + +K+++EK+ ++ ++ +++S+ + + +I +
Sbjct: 839 EKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCS-KSEIHNE 897
Query: 1223 KTEALLEAKTN-----ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC--TVSELE 1275
K + ++ N E + + IL + S + + K +K + LE
Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 1276 AQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS 1335
+ ++ E+ N + + +A +L+ + +++K ++ESL +EK+ L + Q A
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
Query: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAA 1395
++ + + +K+ E+L +K ++ ++ DL QL+NS E
Sbjct: 1018 SYKNLLLEYEKQ-----------SEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE---T 1063
Query: 1396 ISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ 1455
I+S D E +LL +++ L L + + + K + + + +
Sbjct: 1064 INS-----DNE--DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKE 1116
Query: 1456 HQNTV---KELQIQLELKSKEAYEKDEQINLLKEELDQ------QNKRFDCLKGEMEDDK 1506
H TV +ELQ+QL+ + K+ + +++ L+K++ Q + ++ L E+
Sbjct: 1117 HATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176
Query: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
+ K +LE E+K Q + L++ IT SL ++ Y ++K+ + K+L+ K
Sbjct: 1177 TNKNNKIEDLEQEIKIQKQKQETLQEEIT-------SLQSSVQQY-EEKNTKIKQLLVKT 1228
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
+ +EL + K+AE L L+ S+K ELE ++++E + + E +
Sbjct: 1229 K--KELADS-----KQAETDHLILQ---ASLKGELEASQQQVEVYKIQLAEITSEKHKIH 1278
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
+ L++ SA + +Q++ A++++ + ++ + + ++ + +
Sbjct: 1279 EHLKT-SAEQHQRTLSAYQQRVTALQEEC------------RAAKAEQATVTSEFESYKV 1325
Query: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
VH + ++ K+ SQ+ET + +++ +Q + Q Q + +S LQ +
Sbjct: 1326 RVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS-QNNLQINVSELQTLQS 1384
Query: 1747 EKEKLLQRVGQEKEETVSSHFEMR-----CQYQERLIKLEHA----------EAKQHEDQ 1791
E + LL+R + +ETVS E+R Q + ++K EH E ++ +
Sbjct: 1385 EHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR 1444
Query: 1792 SMIGHLQEE-------LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
+ HLQEE L+++ K + Q + ++ + ++Q+L+N L+E
Sbjct: 1445 DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN--------LRE 1496
Query: 1845 KELTCQILEQKIKELDSCLVRQKE---VHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
+ T + LD V ++E + + E ++S Q+L+Q+ N P LE
Sbjct: 1497 RRNT------DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQL--LNSPETKLE 1548
Query: 1902 ENT--EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE 1959
E +K LVQ + A H L L E L ++I L+ ++R L +
Sbjct: 1549 PPLWHAEFTKEELVQKLSSTTKSADH--LNGLLRETEATNAILMEQIKLLKSEIRRLERN 1606
Query: 1960 HQQE-----LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ 2010
++E LE LK Q K E+E L L +T+ QL E +LA Q
Sbjct: 1607 QEREKSAANLEYLKNVLLQFIFLKPGSERERL-LPVINTMLQLSPEEKGKLAAVAQ 1661
Score = 206 bits (525), Expect = 2e-52
Identities = 378/1755 (21%), Positives = 734/1755 (41%), Gaps = 246/1755 (14%)
Query: 132 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191
++L KE LI+ ++ + + + +EL + L R K +G + + R A
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEEL-RSKPVTEGTGDIIKALTERLDAL 81
Query: 192 LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQL 251
L E+ + +QQ +E E +D + L + +++ +K + L
Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQS-------HINYVKEIENL 134
Query: 252 EPQA-EVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT 310
+ + V +K +++ + +E+ ++ T L +++K Q N K+
Sbjct: 135 KNELMAVRSKYSEDKANLQKQLEE--AMNTQLELSEQLKFQNNSEDNVKK---------- 182
Query: 311 LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL------------RDAKNLIEQL 358
L E E ++ +E++ L+K D EK + +TQL ++ +L E+L
Sbjct: 183 -LQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEEL 241
Query: 359 EQDKGMVIAETKR---QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEE 415
Q K + E K Q+ + + E EI +L + + Q E + +K E
Sbjct: 242 LQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELEN 301
Query: 416 LEKALSTAQKTEEARRKLKAE-------MDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
L KA S A + + L E ++E++K +E T +E L+ + S +K EV
Sbjct: 302 LRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKE----LESQHSILKDEVTY 357
Query: 469 V----MKKSSEEQIAKLQKLHEKE-LARKEQELTKKLQTREREFQEQMKVALEKSQSEYL 523
+ +K + Q K + HE+E L K EL +E+ +EK +SE
Sbjct: 358 MNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLA--------KEEQGCVIEKLKSELA 409
Query: 524 KISQE---KEQQESLALEELELQKKAILTE-SENKLRDLQQEAETYRTRILELESSLEKS 579
++++ +Q + ++ L+ Q + ++E +E L D ++E T I L+ E +
Sbjct: 410 GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCE-N 468
Query: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
LQ+ K ++ L E+ K E ES+K QQ + E Q L+ +
Sbjct: 469 LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAF- 527
Query: 640 TEMEKLRE---KCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLEKLDVKQTELESLSS 691
TE + L E + + E E LL +E++ + +++E N L L + T L+ L
Sbjct: 528 TEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG 587
Query: 692 ELSEVLKARHKLEEELSVLKDQTDKMKQELE---------AKMDEQKNHHQQQVDSIIKE 742
+++ + + + +L ++ D ++ E K EQ + +++ + E
Sbjct: 588 KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNE 647
Query: 743 HEVSIQRT--EKALKDQ-INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
++ T EK DQ + +L + +K + + A V++L + + E +Q S
Sbjct: 648 LTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD 707
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL--- 856
L+VF S ++ +E + QL++KL + E+ L K + + QK V T+L
Sbjct: 708 LEVFLS-----QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF 762
Query: 857 ----------DAHKIQVQDLMQ----QLEKQNSE-------MEQKVKSLTQVYESKLEDG 895
D+ + V +++Q L K N E ++KV L + + E+
Sbjct: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
Query: 896 NKEQEQTKQIL--VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE 953
+ E+ K +L E+E ++L +K+ EI ++K + + D + + N +T+ +NQ
Sbjct: 823 VVQCEELKSLLRDYEQEKVLL-----RKELEEIQSEKEALQSDLLEMKNANEKTRLENQN 877
Query: 954 K--KMEKVKQ--KAKEMQETLKKKLLDQEAKLKKELENTALELSQKE----KQFNAKMLE 1005
++E+V Q E+ +K + + LK LE L + E K AK
Sbjct: 878 LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 1006 MAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI-HEI 1064
+ + + + ++E +KE E ++++ +L V + +K+L+ +E Q + E+
Sbjct: 938 VKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA--KKELDSSRKETQTVKEEL 995
Query: 1065 QLQEKEQEVAELKQKILLFGCEK--------EEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
+ E++ + L+ G E E+ ++++ KE + + +L QL+
Sbjct: 996 ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR 1055
Query: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
+ ++ D L A +E L+ N L E L+ Q + + E + K+ +
Sbjct: 1056 NSTLQCETINSDNEDLLARIETLQ--SNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQ 1112
Query: 1177 KLK---TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
K+K TT E + L+ +K K L+ K +EL
Sbjct: 1113 KIKEHATTVNELEELQVQLQKEKKQLQ-------KTMQEL-------------------- 1145
Query: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLN---I 1290
EL+ + +T + I+ + ++ + L K + +LE +++ ++Q TL
Sbjct: 1146 ELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEIT 1205
Query: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
S Q + Q EEK +IK + LV K KE + +QA ++ LK EL
Sbjct: 1206 SLQSSVQQYEEKNTKIKQL------LVKTK----KELADSKQAETDHLILQASLKGELEA 1255
Query: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
+ V + K +L E E + + L Q Q ++S ++ +++L+++ K E
Sbjct: 1256 SQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR--VTALQEECRAAKAEQ 1313
Query: 1411 LDQVQDL-SFKV---DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQ 1466
+ S+KV + L ++K ++ Q + K Q + ++ L Q
Sbjct: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK-------------QEREHLEMLIDQ 1360
Query: 1467 LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
L++K +++ + + QIN+ EL D L + KE+ L +L S +
Sbjct: 1361 LKIKLQDS-QNNLQINV--SELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417
Query: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
M ++ TQ ++ S NEVL+N ++ V+ LQ EE V+ +++
Sbjct: 1418 NMMMKSEHTQTVSQLTSQNEVLRN-------SFRDQVRHLQ------EEHRKTVETLQQQ 1464
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE-SAAKLAELKRKAE 1645
+ +E Q++ +K E T+ S S ++ LK L +R ++ + + R+
Sbjct: 1465 LSKMEAQLFQLKNEPTTR---------SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEG 1515
Query: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSET 1705
+ + + +S Y + E L+ TKL+ +E+L SS +
Sbjct: 1516 EGMETTDTESVS----SASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTT-- 1569
Query: 1706 LIVPRSAKNVAAYTEQEEADSQGCVQ--KTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763
+SA ++ + EA + ++ K + +I L+RN E+EK + K +
Sbjct: 1570 ----KSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERN-QEREKSAANLEYLKNVLL 1624
Query: 1764 SSHFEMRCQYQERLI 1778
F +ERL+
Sbjct: 1625 QFIFLKPGSERERLL 1639
Score = 166 bits (419), Expect = 3e-40
Identities = 257/1274 (20%), Positives = 547/1274 (42%), Gaps = 175/1274 (13%)
Query: 72 VESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNS 131
+ + ++ + ES + S + ++ ++ L TA + + +++ N
Sbjct: 486 IMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENE 545
Query: 132 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191
L++++L+ L ++L G Y ++ + +E + L++ +D + ++
Sbjct: 546 KLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN 605
Query: 192 LREELQMDQQAKKHLQE-----EFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
EE MD KK +E E +E+ QY S L+ +V+ L L + LK
Sbjct: 606 SHEE--MDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE------ETLK 657
Query: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHK 306
Q + + E + S+ + V+ VK+L ++ ++ L R E S K
Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVL--SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK 715
Query: 307 EQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
E L E + +LEK K +L+ + +D N + + EQ + + +
Sbjct: 716 EDVI------------LKEHITQLEK--------KLQLMVEEQDNLNKLLENEQVQKLFV 755
Query: 367 AETKRQMHETL-EMKEE--EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
K Q++ L EM E E ++ + + + GE L + E+ AF+ EK L
Sbjct: 756 ---KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-L 811
Query: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
+K + ++ E++K++ + E+E++ L++EL ++ E K++ + + +++
Sbjct: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE-----KEALQSDLLEMKN 866
Query: 484 LHEKELARKEQELTKKLQTRE----REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
+EK + L + + + E + + K + ++KE ++ A E
Sbjct: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRA--E 924
Query: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
L L K + L +S + D + +I LE K +E N+ K +AV + E +
Sbjct: 925 LILLKDS-LAKSPSVKNDPLSSVKELEEKIENLEKEC-KEKEEKINKIKLVAVKAKKELD 982
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK--QQYQT---EMEKLREKCEQEKE 654
KE + K ELESL+ ++D L +++ + Y+ E EK E+ + EKE
Sbjct: 983 SSRKETQTV----KEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
+ F+ IE++ +L + E+++S+ ++L L+ +L+ Q
Sbjct: 1039 -----RANNFEHRIEDLT----RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQI 1089
Query: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
++ Q +A +D++ + Q + IKEH ++ +++ +L++ L++ K L++
Sbjct: 1090 LEV-QRAKAMVDKELEAEKLQKEQKIKEHATTV--------NELEELQVQLQKEKKQLQK 1140
Query: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
+E ++ D +++ + + + YE + +L QKL + +
Sbjct: 1141 TMQELELVKKDAQQT------------------TLMNMEIADYERLMKELNQKLTN-KNN 1181
Query: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
+I +Q +++ QK++ L +Q +QQ E++N++++Q + ++K E
Sbjct: 1182 KIEDLEQEIKIQKQKQET---LQEEITSLQSSVQQYEEKNTKIKQ------LLVKTKKEL 1232
Query: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
+ +Q +T ++++ + E ++++E+ +L+ H ++E +T + ++
Sbjct: 1233 ADSKQAETDHLILQAS--LKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR 1290
Query: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
+ +Q+ +QE + +Q A + E E+ + + KQ K + A+ A
Sbjct: 1291 TLSAYQQRVTALQEECRAAKAEQ-ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA-- 1347
Query: 1015 SDAVSRLETNQKEQIESLTEVHRRELND-----VISIWE-KKLNQQAEELQEIHEIQLQE 1068
++E +E L + + +L D I++ E + L + + L E H LQE
Sbjct: 1348 --------KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQE 1399
Query: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE-LQEQLKQKSAHVNSLAQ 1127
+ AEL++K+ E M E T + V Q T+ NE L+ + + H+
Sbjct: 1400 TVSKEAELREKLCSIQSENMMMKSEHT----QTVSQLTSQNEVLRNSFRDQVRHL----- 1450
Query: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
+ + + +E L+ L+K ++ QL +LK +E T++ + + QS
Sbjct: 1451 -QEEHRKTVETLQQQLSK-------MEAQLFQLK----------NEPTTRSPVSSQ--QS 1490
Query: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247
LK+ E+ N L + + ++ +E E ++ +S+ T ++
Sbjct: 1491 LKNLRERRNTDLP-------------LLDMHTVTREEGEGMETTDTESVSSASTYTQSLE 1537
Query: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307
++ + TK++ L T EL +L T+ + LN ++ QIK
Sbjct: 1538 QLLNSPE---TKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIK 1594
Query: 1308 SMKADIESLVTEKE 1321
+K++I L +E
Sbjct: 1595 LLKSEIRRLERNQE 1608
Score = 125 bits (314), Expect = 5e-28
Identities = 232/1089 (21%), Positives = 446/1089 (40%), Gaps = 178/1089 (16%)
Query: 8 KISEEQQQLQQALAPAQASSNS----STPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
K+S E++QL + L + T++ + E+ D E+ Q
Sbjct: 696 KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV 755
Query: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR--ESLNRLDLDSSTASFDPPSDMD 121
K QL F + + S ++ +V ESL +++ + +F D
Sbjct: 756 KTQLYG------FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQ----RD 805
Query: 122 SEAEDLVGNSDSLNKEQLIQ------RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
+ +L L +E ++Q LR E+ R + E+ + + LQ + +++
Sbjct: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMK 865
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEE---------FDASLEEKDQYISVLQT 226
+++ ++ + ++ E Q +++ H ++E LE+K+ + +
Sbjct: 866 NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE--LRDRRA 923
Query: 227 QVSLLKQRLRNGP-MNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285
++ LLK L P + D L + +LE K EN E + + E +K +
Sbjct: 924 ELILLKDSLAKSPSVKNDPLSSVKELEE------KIENLEKECKEKEEKINKIKLVA--- 974
Query: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM------- 338
VK ++ L KET Q+ KE+ L SEK+ L + + +Q E K+L +
Sbjct: 975 --VKAKKELDSSRKET-QTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
Query: 339 ---AEKTK----------LITQLRDAKNLIEQLEQDKGMVIA--ETKRQMHETLEMKEEE 383
EK + L QLR++ E + D ++A ET + + LE++ E
Sbjct: 1032 QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILE 1091
Query: 384 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT 443
+ + ++ + + + +EQK K ELE+ QK ++ +K E++ K
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 444 IEKT-------SEEERI--SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
++T ++ ER+ L Q+L+ ++ D+ EQ K+QK ++ L Q
Sbjct: 1152 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDL------EQEIKIQKQKQETL----Q 1201
Query: 495 ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
E LQ+ ++++E + ++ + L + +KE +S E L +A L + +
Sbjct: 1202 EEITSLQSSVQQYEE------KNTKIKQLLVKTKKELADSKQAETDHLILQASL---KGE 1252
Query: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK--- 611
L QQ+ E Y+ ++ E+ S K + K ++ L A + + +T + E+
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSA----YQQRVTALQEECRA 1308
Query: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKETLLKDKEIIFQAHIEE 670
K E ++ + ++ VLKQQ M + E +QE+E L + +I Q I+
Sbjct: 1309 AKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHL---EMLIDQLKIKL 1365
Query: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
+ + L + +EL++L SE +L+ +K+ +E + + + ++++ K+
Sbjct: 1366 QDSQ--NNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
Query: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
H Q V + ++EV + +DQ+ L+ +EH+ VE L+ + + E
Sbjct: 1424 EHTQTVSQLTSQNEV----LRNSFRDQVRHLQ----------EEHRKTVETLQQQLSKME 1469
Query: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK------LLDLETERILLTKQVAE 844
+L FQ T + ++ L L+++ LLD+ T
Sbjct: 1470 AQL---------FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT----------- 1509
Query: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
V ++ + D + S Q ++ L E+KLE E TK+
Sbjct: 1510 VTREEGEGMETTDTESV----------SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKE 1559
Query: 905 ILVEKENMILQMRE---GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961
LV+K + + + G +E E L + I +L E +NQE ++
Sbjct: 1560 ELVQKLSSTTKSADHLNGLLRETEATNAILM---EQIKLLKSEIRRLERNQE------RE 1610
Query: 962 KAKEMQETLKKKLLD-------QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
K+ E LK LL E + + NT L+LS +EK A + + + N++
Sbjct: 1611 KSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRS 1670
Query: 1015 SDAVSRLET 1023
S S L +
Sbjct: 1671 SGWASYLHS 1679
Score = 67.4 bits (163), Expect = 1e-10
Identities = 84/362 (23%), Positives = 156/362 (43%), Gaps = 72/362 (19%)
Query: 1821 GKNNIQA--KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878
GK+ ++ K++L +Q+ + C LE++I+EL R K V + +
Sbjct: 18 GKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEEL-----RSKPVTEGTGDIIK 72
Query: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
+ E+L AL LLE+ E+ L + + E + + + A E E
Sbjct: 73 ALTERLDAL-----------LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELE 121
Query: 1939 KQKLG--KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNS--TL 1994
+ + KEI L+ +L +R ++ ++ L+K+ ++ +++ E L+ ++NS +
Sbjct: 122 QSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELS-EQLKFQNNSEDNV 180
Query: 1995 KQLMRE-------FNTQLAQKEQELEMTIKE---------------------TINKAQEV 2026
K+L E F Q+ +++L+ T E IN QE
Sbjct: 181 KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE 240
Query: 2027 EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
+L HQEE +L+ +I + +AK +E ++ E V+ + + +QK
Sbjct: 241 LLQLKAIHQEEVKELMCQI-------EASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293
Query: 2087 KYQQKLEQ----EENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
KY+ +LE N DN ++ + L Q+ T + EQ E++ +LED LK+
Sbjct: 294 KYECELENLRKATSNANQDN----QICSILLQENTFV------EQVVNEKVKHLEDTLKE 343
Query: 2143 YE 2144
E
Sbjct: 344 LE 345
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 237 bits (605), Expect = 8e-62
Identities = 465/2340 (19%), Positives = 971/2340 (41%), Gaps = 380/2340 (16%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRM--RSRTSSFTEQLDEGTPNRESGDTQS 60
++ +++ ++ +QL Q + Q +S T + R S + QL ++++ +
Sbjct: 163 RRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQL-----SKKNYELIQ 217
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR-ESLNRLD---------LDSS 110
+ ++Q + E + ++ R + +ES+ + NR+ +D
Sbjct: 218 YLDEIQTLTEANEKI---EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQL 274
Query: 111 TASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE 170
D E DL+ + + + ++ ++E K E++ QML
Sbjct: 275 KKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNL 334
Query: 171 KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230
++KL+ + DKS + L++ +Q K L E+ + +E ++ +++ +
Sbjct: 335 REKLKNAQLDA-DKS--NVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE 391
Query: 231 LKQRLRNGPMN----------VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
L++ ++ +D+LK + + + + E D E V ++K
Sbjct: 392 LQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELV----EALKR 447
Query: 281 LETLQQRVKRQENL---LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD-L 336
L+ + V E+ +K CK I+ + +LT E L+ ++ + L E E +++ +
Sbjct: 448 LKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERV 507
Query: 337 HMAEKTKL-ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 395
+ KT + +T+ R++K+L +Q + + ++ + +E EEE L+ +I+QM
Sbjct: 508 GLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKE-------IESLEEERLDLKKKIRQMA 560
Query: 396 TQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EER 452
+ R ++ + E+L + +Q + RKL + + + +E E
Sbjct: 561 QE----RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSREL 616
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQELTKKLQTREREFQ-- 508
I +++L R + V+ + +E + + ++L E KE+ + +E+ K + E
Sbjct: 617 IEKERDLER-SRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLI 675
Query: 509 ----EQMKVALEKSQSEYL---------KISQEKEQQESLALEELELQKKAI-----LTE 550
E++ A+E +E + ++ Q + E L E E +K+AI L +
Sbjct: 676 IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAK 735
Query: 551 SENKLRDLQQEAETYRT--------RILELESSLEKSLQENKNQSKDLAVHLEAE---KN 599
+ K+ L++E R + ++L + S N + +HL E K
Sbjct: 736 ANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC----EQEKET 655
K K + +E + + ++HQQ L+ E L K+ ++TE + ++E+ +Q ++
Sbjct: 796 KKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSE-KETWKTESKTIKEEKRKLEDQVQQD 854
Query: 656 LLKDKEI-----IFQAHIEEMNEKTLE---KLDVKQTELESLSSELSEVLKARHKLEEEL 707
+K KE Q +EM + E K+ V Q +SL + + +++ +L +E
Sbjct: 855 AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKEN 914
Query: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI-----IKEHEVSIQRTEKALKDQINQLE 762
K++ M+ E+ K+ + + + I + ++ VS+ E A K Q N+L
Sbjct: 915 EKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANK-QYNELT 973
Query: 763 LLLKE---RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV----FQSYQSATHEQTK 815
++ +D L + +++E+LE + + +++ + +L++ + + A ++TK
Sbjct: 974 AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK 1033
Query: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEA------QKKDVCTELDAHKIQVQDLMQQ 869
E +K + ++ + ++K++ +E Q+ + C ++ H ++ ++Q
Sbjct: 1034 LGNESSMDKAKKSIT-NSDIVSISKKITMLEMKELNERQRAEHCQKMYEH---LRTSLKQ 1089
Query: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
+E++N E+E K LT++ N + ++ +Q+L + E+
Sbjct: 1090 MEERNFELETKFAELTKI--------NLDAQKVEQML--------------RDELADSVS 1127
Query: 930 KLSAKEDSIHILN-EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENT 988
K + D IL E+ E + K + K+ ++ A+ E L Q+ KE+E+
Sbjct: 1128 KAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNA----QQQSRDKEVESL 1183
Query: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
++L + Q + K L +A+ + +S +S E ++ES+T ++ + +
Sbjct: 1184 RMQLLDYQAQSDEKSL-IAKLHQHNVSLQLS--EATALGKLESITSKLQK-----MEAYN 1235
Query: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKI---------LLFGCEKEEMNKEITWLKE 1099
+L Q+ +E ++ E L+Q I L ++E+ +K + L+
Sbjct: 1236 LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN 1295
Query: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
+ +K + +++K ++ +++ L+ LE +L +LK+ Q+ ++
Sbjct: 1296 DKLK-------IMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK-VIN 1346
Query: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLK---SSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
M EE + + +L +L EE + L S +E++ SLE++ ++ K EE +
Sbjct: 1347 WHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA 1406
Query: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276
D + E LE + ++I + N IL+ + T + + L ++LE
Sbjct: 1407 WD----QREVDLERQ----LDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP---NQLEI 1455
Query: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
LR++ E + + + LEEK + +S E + ++ + E + A +E
Sbjct: 1456 ALRKIKENIRII-LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAE 1514
Query: 1337 KESCITQLKKELSENINAVTL---------MKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
+E I +L ++ E + TL M+ L +K+ + + L + + +
Sbjct: 1515 REKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 1574
Query: 1388 SLSEKEAAI--SSLRKQYDEEKCELLDQVQDLSFKVDT----------LSKEKISALEQV 1435
E++ I L Q D + DL + T L++ + + EQ
Sbjct: 1575 KKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQD 1634
Query: 1436 DDWSNKFSEWKKKAQSRFTQHQNT---VKELQ-IQLELKSK---EAYEKDEQINLLKEEL 1488
D S+ + KK +Q Q + T VKE + I+L+L+ E + ++ LK L
Sbjct: 1635 DSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLL 1694
Query: 1489 DQQNKRFDCLKGEMEDDKSKMEKKES----NLETELKSQTA-----------RIMELEDH 1533
DQ K CLK E++ K + + NL LKSQ A ++EL
Sbjct: 1695 DQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAE 1754
Query: 1534 IT----QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
+T ++ I S E N Q D +EL +++ E + +K ++ + +
Sbjct: 1755 MTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENS 1814
Query: 1590 LENQVYSMKAELETKKK----------ELEHVNLSVKSKEEEL------KALEDRLES-- 1631
L + + + EL+ K+K E++ N +K + + L K L D +S
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
Query: 1632 -ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK----KGTESHLSELNTKLQERER 1686
E K+ +L+ + E K+ + + + + KEE + K ++ + + KL+E+E
Sbjct: 1875 EELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEG 1934
Query: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
EV L ++L ++ K++ A ++E+ Q ++ T VL
Sbjct: 1935 EVFTLTKQLNTL--------------KDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL 1980
Query: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQY---QERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803
E EK L+ + + + + MR ++ +++ H + + +LQE+L
Sbjct: 1981 ESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNR---------YLQEKLHA 2031
Query: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
K++S + +K ++ + D +E+EL
Sbjct: 2032 LEKQFS-------------KDTYSKPSISGIESD-DHCQREQEL---------------- 2061
Query: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE--EKSKSHLVQPKLLSNM 1921
QKE ++ E + K++ QA + + L+E E +K K+ VQ KL
Sbjct: 2062 --QKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAE-VQRKL---- 2114
Query: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK---EHQQELEILKKE---YDQER 1975
G R + GK I L+K + +++K + Q+E E LKK E+
Sbjct: 2115 ------------GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEK 2162
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ 2035
I+QE E L+ + L + + K + E I E
Sbjct: 2163 MANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAE----------------- 2205
Query: 2036 EETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
N+ L+K +K+ D + + L+ E+MT ++ + +L+ + + Q LE
Sbjct: 2206 ---NERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQ-LEGA 2261
Query: 2096 ENPGNDNVTI--------MELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
++ ++ + EL+T +A+K I+D K +E E+ E ++ KY +++
Sbjct: 2262 DSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATER----EQKVNKYNEDL 2317
Score = 225 bits (574), Expect = 3e-58
Identities = 438/2072 (21%), Positives = 881/2072 (42%), Gaps = 347/2072 (16%)
Query: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
+E + L+ +SL +E+L L++ R ++ RGK S A L E L +SQ
Sbjct: 533 AENQILLKEIESLEEERL--DLKKKIRQMAQERGKRS----ATSGLTTEDLNLTENISQG 586
Query: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMN 241
S R++ L + + Q+K E L EK++ + +T ++ + +L+
Sbjct: 587 DRISERKLDLLSLKNMSEAQSKN---EFLSRELIEKERDLERSRTVIAKFQNKLK----- 638
Query: 242 VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKET 301
++++ QLE + + E +P V+ G + + +L++ V E+
Sbjct: 639 -ELVEENKQLEEGMKEILQAIK-EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
Query: 302 IQSH-KEQCTLLTSEKEALQEQLDERLQEL---------EKIKDLHMAEKTKLITQLRDA 351
H K Q LT E L+++L E +E +K H+ ++T L+ Q +
Sbjct: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756
Query: 352 KNLIEQLEQDKGM-------VIAETKRQMH--ETLEMKEEEIAQLRSRIKQMTTQGEELR 402
+ + ++ G+ + ++ + +H + LE KE+++ L ++ + +R
Sbjct: 757 NVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIR 816
Query: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ----------IKTIEKTSEEER 452
Q+ + E E + ++ +E +RKL+ ++ + + ++ S+E +
Sbjct: 817 HQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMK 876
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
L + ++ V+ V +KS Q L +L E++L ++ ++ +L + E E E++
Sbjct: 877 KILAENSRKIT--VLQVNEKSLIRQYTTLVEL-ERQLRKENEKQKNELLSMEAEVCEKIG 933
Query: 513 VALEKSQSEYLKISQ-EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE 571
+ KI+ +K S++L ELEL K E K RD+ Q+ R
Sbjct: 934 CLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQY-NELTAKYRDILQKDNMLVQRTSN 992
Query: 572 LESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKL 631
LE HLE E N + VE ELE K EKL
Sbjct: 993 LE-------------------HLECE----NISLKEQVESINKELEITK--------EKL 1021
Query: 632 QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
++Q ++ E + E + + + + +I+ + K T LE
Sbjct: 1022 HTIEQAWEQETKLGNESSMDKAKKSITNSDIV--------------SISKKITMLEM--K 1065
Query: 692 ELSEVLKARH--KLEEELSVLKDQTDKMKQELEAKMDE--QKNHHQQQVDSIIKEHEVSI 747
EL+E +A H K+ E L Q ++ ELE K E + N Q+V+ ++++
Sbjct: 1066 ELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELAD- 1124
Query: 748 QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807
KA+ D Q L L++ + LK + + + +DI R + E+ A
Sbjct: 1125 -SVSKAVSDADRQRILELEKNEMELKVEVSKLREI-SDIARRQVEILNA----------- 1171
Query: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ--- 864
Q ++ ++++ L+ +LLD + + + +K + +L H + +Q
Sbjct: 1172 -----QQQSRDKEVESLRMQLLDYQAQ------------SDEKSLIAKLHQHNVSLQLSE 1214
Query: 865 -----------DLMQQLEKQNSEMEQKVKSLTQ-VYESKLEDGN--KEQEQTKQILVEKE 910
+Q++E N +EQK+ Q +Y ++LE N K QT Q L +
Sbjct: 1215 ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQF 1274
Query: 911 NMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970
+ L + + +K + + D + I+ E KN +++ ++ K EM+ L
Sbjct: 1275 SGALPLAQQEK----FSKTMIQLQNDKLKIMQE-----MKNSQQEHRNMENKTLEME--L 1323
Query: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
K K L++ K+ + +QK ++ K+ E+ + L+ N +E ++
Sbjct: 1324 KLKGLEELISTLKDTKG-----AQKVINWHMKIEELR----------LQELKLN-RELVK 1367
Query: 1031 SLTEVHRRELNDVISIWEKKLNQQAEEL---QEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
E+ + LN++IS +E+ ++ EE+ + HE + +Q +L++++ +F ++
Sbjct: 1368 DKEEI--KYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQ 1425
Query: 1088 EE-MNKEITWLKEEGVKQDTTL---NELQEQLKQKSAHVNSLAQDETKLKAHLEKL-EVD 1142
E +N + + G D +L N+L+ L++ ++ + + K+ EKL E +
Sbjct: 1426 NEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKE 1485
Query: 1143 LNKSLKENTFLQEQLV----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE----- 1193
L E L V L++ A ++ K+ + + + +LK +H+
Sbjct: 1486 SALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545
Query: 1194 ------------KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN-------E 1234
K + LE E +++ ++ L I + E ++ N +
Sbjct: 1546 QARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD 1605
Query: 1235 LINISSSK--TNAILSRISHCQHRTTKVKEAL---LIKTCTVSELEAQLRQLTEEQNTLN 1289
L+ S + TN R++ + + ++L L+K VS+ + R++TE +
Sbjct: 1606 LMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVK-- 1663
Query: 1290 ISFQQATHQLEEK-ENQIKSMKADIESLVTEKEALQKEGG---NQQQAASEKESCITQLK 1345
F+ QL+E E+++K +KA++E L + QKE ++ QA E S +
Sbjct: 1664 -EFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS-----R 1717
Query: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-----QNSISLSEKEAAISSLR 1400
+ N V +K +L K+ + +LS+ L +L ++ + IS + ++ A +++
Sbjct: 1718 APTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQ 1777
Query: 1401 KQYDEEKCELLDQVQDLSFKVDTL------SKEKISAL-EQVDDWSNKFSEWKKKAQSRF 1453
+ D EL QV+DL+ + L SK + ++L + ++D +N+ + K+KA ++
Sbjct: 1778 QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK-KQKAYNKI 1836
Query: 1454 TQHQNTVKELQIQLELKSKEAYE-------KDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
+ + + + +L+ + K D + +L++E + K + L+G++E+
Sbjct: 1837 LREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVD 1896
Query: 1507 SKMEKKESNLETEL------KSQTARIMELEDHITQKTIEIESLNE---VLKNYNQQKDI 1557
K KE N + EL K A+I + + + +K E+ +L + LK+ + D
Sbjct: 1897 LK-PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK 1955
Query: 1558 EHKELVQKLQHF-----QELGE---EKDNRVKEAEEKILTLENQVYSMKAELETKKKEL- 1608
E L +KL+ Q LG E + ++E +++ L LEN + M+A + +
Sbjct: 1956 EKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVV 2015
Query: 1609 EHVNLSVKSKEEELKALEDR-------------LESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++L + +E+L ALE + +ES+ + + +K K+++ +L
Sbjct: 2016 EDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL 2075
Query: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Q+E+ + + ++ + +L + ++E ++ KL V S +P K +
Sbjct: 2076 KFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTI 2134
Query: 1716 AAYTEQEEADSQGCVQK-------TYEEKISVLQRN---LTEKEKLLQRVGQEKEETVSS 1765
+ E + Q T E+ ++ Q N E EKL +G + +S
Sbjct: 2135 GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ----LSM 2190
Query: 1766 HFEMRCQYQERLI-----------KLEHAEAKQHEDQSMIGHLQE----ELEEKNKKYSL 1810
H+E + + E++I K A K ++ + L E +LEE K+
Sbjct: 2191 HYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
Query: 1811 IVAQHVEKEGGKN----NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
++ + EG + +I + E +++ + +K + L+Q +KE R+
Sbjct: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATE---RE 2307
Query: 1867 KEVHRVEMEELTSKYEKL----QALQQMDGRNKPTELLE--ENTEEKSKSHLVQP----K 1916
++V++ E+L + + L + + G + ++L + +K K+ L+ K
Sbjct: 2308 QKVNKYN-EDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANK 2366
Query: 1917 LLSNMEA----------QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEI 1966
S E+ + DLE +L ++ EKQ L +EI +L+K+L +E+E
Sbjct: 2367 DQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIED 2426
Query: 1967 LKKEYDQE------REEKIKQEQEDLELKHNS 1992
LK Y +E EEK+K+ E L ++ S
Sbjct: 2427 LKYNYKEEVKKNILLEEKVKKLSEQLGVELTS 2458
Score = 218 bits (556), Expect = 4e-56
Identities = 409/1934 (21%), Positives = 808/1934 (41%), Gaps = 320/1934 (16%)
Query: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE----KEQQESL 535
++ K+ +L R+E+ L + + ++K +++ +I+Q K Q+ L
Sbjct: 9 EIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVEL 68
Query: 536 ALEELEL----------QKKAILTESENKLRDLQQEAETYRTRILELE-SSLEKSLQENK 584
ALEE+E Q K + + EN+L QQ A TR L E LEK L++
Sbjct: 69 ALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKD 128
Query: 585 NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644
+ +D+ LE EK K N+++ + E+ + E L+ + ++L+ +Q ++
Sbjct: 129 RELEDMEKELEKEK-KVNEQLALRNEEAENENSKLRREN-----KRLKKKNEQLCQDIID 182
Query: 645 LREKCEQEKETLL--KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
+++ + +KETLL + ++ +++ + + N + ++ LD QT E+ + + R
Sbjct: 183 YQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN 242
Query: 703 LEE---ELSVLKDQTDKMKQELEA------KMDEQKNHHQQQVDSI---IKEHEVSIQRT 750
LEE E+ + D+ ++MK + ++ ++ +H+Q QV + +K
Sbjct: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302
Query: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
A+ ++ + +L+L +D + E+Q + NL +K ++ + +++ + Q
Sbjct: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNV-----MALQQGI 357
Query: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK----------KDVCTELDAHK 860
E+ + Q++Q ++E ++ E++ K + + LD K
Sbjct: 358 QERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILK 417
Query: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 920
+ ++ + E ++ +K K L + + +L+D + +VE +N Q++ +
Sbjct: 418 EKTKEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKNQIKI-R 475
Query: 921 KKEIEILTQKLSAKEDSIHILNEEYE----------------TKFKNQEKKMEKVKQKAK 964
+EIEILT++++ E I +E E T+F+N K K +Q
Sbjct: 476 DREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNS--KHLKQQQYRA 533
Query: 965 EMQETLKK--KLLDQEAKLKKELENTALELSQKEKQ--FNAKMLEMAQANSAG------- 1013
E Q LK+ L ++ LKK++ A E ++ + L + + S G
Sbjct: 534 ENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERK 593
Query: 1014 --------ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ 1065
+S+A S+ E +E IE ++ R VI+ ++ KL + EE +++ E
Sbjct: 594 LDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT--VIAKFQNKLKELVEENKQLEE-G 650
Query: 1066 LQEKEQEVAELKQKILLFGCEK-------EEMNKEITWLKEEGV---------------- 1102
++E Q + E+++ + G E E + I EG+
Sbjct: 651 MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTG 710
Query: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ-------- 1154
+ + EL+E K+ + LA+ K+ HLEK L +S N +
Sbjct: 711 RNEELRQELRESRKEAINYSQQLAKANLKID-HLEKETSLLRQSEGSNVVFKGIDLPDGI 769
Query: 1155 ------------EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH---------E 1193
E L+ L E ++K+ L L+ + +F ++ E
Sbjct: 770 APSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSE 829
Query: 1194 KSNKSLEDKSLEFKKLSEELAIQLD-ICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
K E K+++ +K E +Q D I K+ LL A + + S + IL+ S
Sbjct: 830 KETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA-----LQMDSDEMKKILAENSR 884
Query: 1253 CQHRTTKVKEALLIKT-CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311
+ +V E LI+ T+ ELE QLR+ E+Q +S + ++ EK ++ K
Sbjct: 885 -KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA---EVCEKIGCLQRFK- 939
Query: 1312 DIESLVTEKEALQKEGGN-----QQQAASEKESCITQLKKELSENINAVTLMKEELKEKK 1366
E + + ALQK N + + A+++ + +T +++ + N + L+ +
Sbjct: 940 --EMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLE 997
Query: 1367 VEISSLSKQLTDLNVQLQ-NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
E SL +Q+ +N +L+ L E A K +E +D+ + D +S
Sbjct: 998 CENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESS---MDKAKKSITNSDIVS 1054
Query: 1426 -KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL 1484
+KI+ LE + + +E +K ++E +LE K E +INL
Sbjct: 1055 ISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAEL----TKINLD 1110
Query: 1485 KEELDQ--QNKRFDCLKGEMED-DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
++++Q +++ D + + D D+ ++ + E N E ELK + +++ E+ D I ++ +EI
Sbjct: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKN-EMELKVEVSKLREISD-IARRQVEI 1168
Query: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI-LTLENQVYSMKAE 1600
L Q +D E + L +L +Q +EK K + + L L K E
Sbjct: 1169 ------LNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLE 1222
Query: 1601 LETKK-KELEHVNLSVKSK--EEELKALEDRLESESAAK-----LAELKRK--------A 1644
T K +++E NL ++ K E+E RLE + AK + L+R+
Sbjct: 1223 SITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQ 1282
Query: 1645 EQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
++K + QL + + ++ K + H + + K E E ++ LEE + +++ ++
Sbjct: 1283 QEKFSKTMIQLQNDKLKIMQEMKNSQQEHRN-MENKTLEMELKLKGLEELISTLKDTKGA 1341
Query: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764
++ K ++ + + + K E+I L ++E E+ + + +E +
Sbjct: 1342 QKVINWHMKIEELRLQELKLNRELVKDK---EEIKYLNNIISEYERTISSLEEEIVQQNK 1398
Query: 1765 SHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKY---SLIVAQHVE--KE 1819
H E + + +R + LE Q+ I + ++ EE SL + +E
Sbjct: 1399 FHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALR 1458
Query: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL-----------VRQK- 1867
K NI+ +++ L+EKE ++ EQ I D + R+K
Sbjct: 1459 KIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKL 1518
Query: 1868 --EVHRVEMEELTSKYEKL--QALQQMDGR--------NKPTELLEENTEEKSKS----- 1910
E+ R EME + K+ Q + M R K LLE+ EE+ +
Sbjct: 1519 IAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE 1578
Query: 1911 ---HLVQPKLLSNMEAQHNDLE--------------------FKLAGAER----EKQKLG 1943
H++ +L ++ N + +LA E+ + L
Sbjct: 1579 EDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLS 1638
Query: 1944 KEIVRLQKDLRMLRKEHQ------QELEILKKEYDQEREE---KIKQEQEDLE------- 1987
+V+L+K + L ++ + +E E +K + + E+ K+K E EDL+
Sbjct: 1639 SLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQ 1698
Query: 1988 -----LKH-------------NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
LK +T++ L+ +QLA KE++ + + + E+ A
Sbjct: 1699 KESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAA 1758
Query: 2030 LLE-----SHQEETNQLLKKIAEKD--------DDLKRTAKRYEEILDA---REEEMTAK 2073
E + Q+E + +++I ++ +DL + +E L RE +T
Sbjct: 1759 AEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDN 1818
Query: 2074 VRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI 2133
+ DL +L++ QK Y + L ++E +N EL+ Q+ + T+ + L + + + I
Sbjct: 1819 LNDLNNELQKKQKAYNKILREKEEIDQEN---DELKRQIKRLTSGLQGKPLTDNK-QSLI 1874
Query: 2134 HNLEDRLKKYEKNV 2147
L+ ++KK E +
Sbjct: 1875 EELQRKVKKLENQL 1888
Score = 197 bits (502), Expect = 7e-50
Identities = 388/1882 (20%), Positives = 790/1882 (41%), Gaps = 307/1882 (16%)
Query: 34 RMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESL 93
++ R ++L E +E+ + K L++ +E + SL R S ++
Sbjct: 707 QLTGRNEELRQELRES--RKEAINYSQQLAKANLKIDHLEK------ETSLLRQSEGSNV 758
Query: 94 VRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSY 153
V +DL A S ++S+ E L+ L ++ ++L+ +E SL Y
Sbjct: 759 V-------FKGIDLPDGIAP-SSASIINSQNEYLIHLLQELENKE--KKLKNLEDSLEDY 808
Query: 154 RGKYSEL------------------VTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
K++ + T + ++ EK+KL+ + Q K ++ L
Sbjct: 809 NRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIK-VKEYNNLLNA 867
Query: 196 LQMDQQAKKHLQEEFDASL-----EEKD---QYISVLQTQVSLLKQRLRNG----PMNVD 243
LQMD K + E + EK QY ++++ + L K+ + M +
Sbjct: 868 LQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAE 927
Query: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK----RQENLLKRCK 299
V + + L+ E+ + + + VV++ S+ LE ++ + ++L++
Sbjct: 928 VCEKIGCLQRFKEMAIFKI---AALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDN 984
Query: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD-LHMAEKT-KLITQLRDAKNLIEQ 357
+Q L E +L+EQ++ +ELE K+ LH E+ + T+L + ++ +
Sbjct: 985 MLVQ-RTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
Query: 358 LEQ--DKGMVIAETKRQMHETLEMKEEEIAQ--------LRSRIKQMTTQGEELREQKEK 407
+ + +V K M E E+ E + A+ LR+ +KQM + EL +
Sbjct: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETK--- 1100
Query: 408 SERAAFEELEKALSTAQKTEEARR--------KLKAEMDEQ-IKTIEKTSEEERISLQQ- 457
F EL K AQK E+ R K ++ D Q I +EK E ++ + +
Sbjct: 1101 -----FAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
Query: 458 ----ELSRVKQEVVDVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMK 512
+++R + E+++ ++S ++++ L+ +L + + E+ L KL Q
Sbjct: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEA 1215
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAIL----TESENKLRDLQQEAETYRTR 568
AL K +S K+ +K + +L LE+ +K+ L E N+ + L+Q ++ R +
Sbjct: 1216 TALGKLESITSKL--QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQ 1273
Query: 569 ----------------ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM-VEK 611
+++L++ K +QE KN ++ H E E+ + +E+
Sbjct: 1274 FSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQE---HRNMENKTLEMELKLKGLEE 1330
Query: 612 HKTELESLKHQQDAL-WTEKLQVLK-QQYQTEMEKLREK----------CEQEKETLLKD 659
+ L+ K Q + W K++ L+ Q+ + E +++K E E+ +
Sbjct: 1331 LISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLE 1390
Query: 660 KEIIFQAHIEEMNEKTLEKLDVK-QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
+EI+ Q E + ++ +V + +L+ + +E+L A K EE + D + +
Sbjct: 1391 EEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP 1450
Query: 719 QELEAKMDEQKNHHQ---------QQVDSIIKEHEVSIQRTEKALKDQ---INQLELLLK 766
+LE + + K + + + ++ +KE E +++ E+ + + IN+L L L
Sbjct: 1451 NQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLP 1510
Query: 767 ---ERDKHLKE-----------------HQAHVENLEADIKRSEGELQQASAKLDVFQSY 806
ER+K + E HQ + N++A + + E L++ L+ +
Sbjct: 1511 ATAEREKLIAELGRKEMEPKSHHTLKIAHQT-IANMQARLNQKEEVLKKYQRLLEKAREE 1569
Query: 807 QSATHEQTKAYEEQLAQLQQKLLDLETERIL---------LTKQ-------------VAE 844
Q E K +EE L L +L +L+ + L L KQ +AE
Sbjct: 1570 Q---REIVKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
Query: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
+E + L + ++++ + Q LE+Q E KVK + KL+ +++ K+
Sbjct: 1626 MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENI---KLQLQENHEDEVKK 1682
Query: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
+ E E++ + + QK E + L +L A++++ + T +N ++++ +
Sbjct: 1683 VKAEVEDLKYLLDQSQK-ESQCLKSELQAQKEAN---SRAPTTTMRNLVERLKSQLALKE 1738
Query: 965 EMQETLKKKLLDQEAKLKKELENTALEL-SQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+ Q+ L + LL+ A++ E + SQKE N + + V R
Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI-------------VDRHTR 1785
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
K Q+E L E + +L + + + + N + L +++ +LQ+K++ ++ +
Sbjct: 1786 ELKTQVEDLNE-NLLKLKEALKTSKNRENSLTDNLNDLNN-ELQKKQKAYNKILR----- 1838
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKL--EV 1141
EKEE+++E LK + +K+ T+ + + K + + L + KL+ LE EV
Sbjct: 1839 --EKEEIDQENDELKRQ-IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV 1895
Query: 1142 DLN----KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
DL K+ KE E+ + + E + K+ E ++ T ++ +LK K++K
Sbjct: 1896 DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK 1955
Query: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257
E +L+ K + + + + + E+ E + EL + N IL +H
Sbjct: 1956 --EKLTLQRKLKTTGMTVDQVLGIRALES--EKELEELKKRNLDLENDILYMRAH----- 2006
Query: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
L + V +L Q R L E+ + L F + T+ + I +++D
Sbjct: 2007 -----QALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS----KPSISGIESDDHC-- 2055
Query: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
++ LQKE E + + Q K+L N V +KE + K E + + ++L
Sbjct: 2056 QREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
Query: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
+ ++ ++ E E I ++K ++ + E + L L+ EK++ +EQ ++
Sbjct: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQREN----EQLKKASGILTSEKMANIEQENE 2171
Query: 1438 ----------------WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
S + K + +++ KEL+ + + K K+ +
Sbjct: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNN-L 2230
Query: 1482 NLLKE----ELDQQNKRFDCLKG-----EMEDDKS--------KMEKKESNLETELKSQT 1524
+L E +L++ KR + E D KS E K LET++ +
Sbjct: 2231 EILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
Query: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
I +L+ + + T + +N+ ++ QQ ++ L+H E G E + +K
Sbjct: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQ--------IKILKHVPE-GAETEQGLKREL 2341
Query: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES-ESAAKLAEL-KR 1642
+ + +Q+ KAEL + E +S + L+++++ E+ K+++L K+
Sbjct: 2342 QVLRLANHQLDKEKAEL-IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ 2400
Query: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
+++I +KK+L E + + +L +E ++ +LEEK+K +
Sbjct: 2401 HLKEEIKKLKKEL--------ENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Query: 1703 SETLIVPRSAKNVAAYTEQEEA 1724
L P +A + ++EE+
Sbjct: 2453 GVELTSPVAASE--EFEDEEES 2472
Score = 150 bits (379), Expect = 1e-35
Identities = 309/1469 (21%), Positives = 621/1469 (42%), Gaps = 218/1469 (14%)
Query: 893 EDGNKEQEQTKQILVEKENMILQMREGQKKEIEI----LTQKL-SAKEDSIHILNEEYET 947
+D +++E +L+ + + + +K+E I +TQ L K + + EE E
Sbjct: 16 DDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEK 75
Query: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
+ Q K ++K K +++ L+ + + L N E+ Q EKQ K E+
Sbjct: 76 AGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRN---EICQLEKQLEQKDREL- 131
Query: 1008 QANSAGISDAVSRLETNQK--EQIESLTEVHRRELNDVISIWEKKLNQQAEEL-QEIHEI 1064
D LE +K EQ+ E E N + K+L ++ E+L Q+I +
Sbjct: 132 -------EDMEKELEKEKKVNEQLALRNEEAENE-NSKLRRENKRLKKKNEQLCQDIIDY 183
Query: 1065 QLQEKEQ---------EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Q Q Q E ++ + ++ E + EI L E K + E+++ L
Sbjct: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNL 243
Query: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE----LKMLAEED---- 1167
++ + + + ++KA + + + +++ KEN Q Q+ E LK EED
Sbjct: 244 EESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIM 303
Query: 1168 ---KRKVSELTSKLKTTDEEF-----------QSLKSSH---EKSN-----KSLEDKSLE 1205
KV E L + D+E + LK++ +KSN + ++++ +
Sbjct: 304 VAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQ 363
Query: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTT------K 1259
K L+E++ Q +K ++E NEL +K + LS+ +H + ++T K
Sbjct: 364 IKMLTEQVE-QYTKEMEKNTCIIEDLKNEL---QRNKGASTLSQQTHMKIQSTLDILKEK 419
Query: 1260 VKEALLIKTCTVSELEAQ---------LRQLTEEQNTLNISFQQATHQLEEKENQIKSMK 1310
KEA +T ++E +A+ L++L + ++ + + A +++ +NQIK
Sbjct: 420 TKEA--ERTAELAEADAREKDKELVEALKRLKDYESGV-YGLEDAVVEIKNCKNQIKIRD 476
Query: 1311 ADIESLVTEKEALQ---KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK- 1366
+IE L E L+ + ++ +A E+ + +L+E N+ L +++ + +
Sbjct: 477 REIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQ 536
Query: 1367 ---VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVD 1422
EI SL ++ DL +++ K +A S L + D E + Q +S K+D
Sbjct: 537 ILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTE-DLNLTENISQGDRISERKLD 595
Query: 1423 TLSKEKISALEQVDDW-SNKFSEWKK---KAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
LS + +S + +++ S + E ++ ++++ + QN +KEL + + + E
Sbjct: 596 LLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEIL 655
Query: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES--------NLETELKSQTARIMEL 1530
+ I ++++ D + + +E + +E K + +L+ ++ T R EL
Sbjct: 656 QAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEEL 715
Query: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE------LGEEKDNRVKEAE 1584
+ + E + ++ L N + I+H E L E G + + + +
Sbjct: 716 RQELRESRKEAINYSQQLAKANLK--IDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
Query: 1585 EKILTLENQ-VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR- 1642
I+ +N+ + + ELE K+K+L+++ S++ + + + L+E +
Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETW 833
Query: 1643 KAEQK-IAAIKKQLLSQMEE---KEEQYK---KGTESHLSELNTKLQEREREVHILEEKL 1695
K E K I K++L Q+++ K ++Y + E+ L E R++ +L+
Sbjct: 834 KTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE 893
Query: 1696 KSVESSQSETLIVPR-------SAKNVAAYTEQEEADSQGCVQKTYEE---KISVLQRNL 1745
KS+ + + + R KN E E + GC+Q+ E KI+ LQ+ +
Sbjct: 894 KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
Query: 1746 TEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK----------LEHAEAKQHEDQSMIG 1795
L E E + E+ +Y++ L K LEH E + + +
Sbjct: 954 DNSVSL-----SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVE 1008
Query: 1796 HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855
+ +ELE +K I Q E+E K E+ D +K++ ++ + +K
Sbjct: 1009 SINKELEITKEKLHTI-EQAWEQE-------TKLGNESSMDKAKKSITNSDIVS--ISKK 1058
Query: 1856 IKELDSCLVRQKEVH-RVEMEELTSKYEKLQ-ALQQMDGRN-----KPTELLEENTEEKS 1908
I L+ KE++ R E YE L+ +L+QM+ RN K EL + N + +
Sbjct: 1059 ITMLE-----MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQK 1113
Query: 1909 KSHLVQPKLLSN-------------MEAQHNDLEFKLAGAE-REKQKLGKEIVRLQKDLR 1954
+++ +L + +E + N++E K+ ++ RE + + V + +
Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173
Query: 1955 MLRKEHQQELEILKKEYDQEREE-----KIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009
R + + L + +Y + +E K+ Q L+L + L +L E T QK
Sbjct: 1174 QSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKL--ESITSKLQKM 1231
Query: 2010 QELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEE 2069
+ + +++ K E E L + E N+ K + + L+R ++ L ++E
Sbjct: 1232 EAYNLRLEQ---KLDEKEQALYYARLEGRNR-AKHLRQTIQSLRR---QFSGALPLAQQE 1284
Query: 2070 MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI-MELQTQ-LAQKTTLISDSKLKEQ 2127
+K +Q Q ++L+ + K Q+E+ +N T+ MEL+ + L + + + D+K ++
Sbjct: 1285 KFSKTM-IQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQK 1343
Query: 2128 EFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMM 2187
+ E RL++ + N L + E +YL ++ EY
Sbjct: 1344 VINWHMKIEELRLQELKLN-------------------RELVKDKEEIKYLNNIISEY-- 1382
Query: 2188 GRETKTMAKVITTVLKFPDDQTQKILERE 2216
R ++ + I KF +++ +RE
Sbjct: 1383 ERTISSLEEEIVQQNKFHEERQMAWDQRE 1411
Score = 34.7 bits (78), Expect = 1.1
Identities = 68/360 (18%), Positives = 140/360 (38%), Gaps = 45/360 (12%)
Query: 1 MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
+ KK+ +K+ E +QL++A + S + + + + E+L ++ S +S
Sbjct: 2136 LMKKVVEKVQRENEQLKKA-SGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYES 2194
Query: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
+ + + E L + KE+ ++++ + ++ E LN +
Sbjct: 2195 KTKGTEKIIAENERLRKELKKET---DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFA 2251
Query: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
+S L G K ++ R+ Y K EL T + L+ ++ +
Sbjct: 2252 ESRGPQLEGADSKSWKSIVVTRM---------YETKLKELETDIAKKNQSITDLKQLVKE 2302
Query: 181 SQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQYISVLQTQVSLLKQRLRNG 238
+ ++ +++ + E+L+ + KH+ E E + L+ + Q + RL N
Sbjct: 2303 ATERE-QKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL------------RLANH 2349
Query: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
++ + + + Q+E + +S E + D + L++++K E LK
Sbjct: 2350 QLDKEKAELIHQIEANKD--------QSGAESTIPDA------DQLKEKIKDLETQLKMS 2395
Query: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL 358
Q KE+ L E E +E+E +K + E K I K L EQL
Sbjct: 2396 DLEKQHLKEEIKKLKKELENFDPSF---FEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 232 bits (592), Expect = 3e-60
Identities = 294/1281 (22%), Positives = 566/1281 (44%), Gaps = 220/1281 (17%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+K+Q+L+ L+ +R +K+ + + K+ Q Q+E L ++
Sbjct: 801 LARKAFAKKQQQLSA-LKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDE 859
Query: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
EL K + E + K+ +E E ++LE ++ L + LQ E E
Sbjct: 860 ELLK---VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA------------ETELFA 904
Query: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
+E+ + K ELE + H ++ R + E+E+ +L+++
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLES--------------------RVEEEEERNQILQNE 944
Query: 661 EIIFQAHIEEMNEKTLEKLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719
+ QAHI+++ E+ E+ +Q +LE +++E K+EEE+ +L+DQ K +
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI-----KKMEEEILLLEDQNSKFIK 999
Query: 720 ELE------AKMDEQKNHHQQQVDSIIK---EHEVSIQRTEKALKDQINQLELLLKERDK 770
E + A+ Q +++ ++ K + EV I E+ LK + + L K + K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 771 ----------HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
+ E QA ++ L+ + + E ELQ A A+ D +++ + + + Q
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQD--------------- 865
+A+LQ+ D E+E+ K E QK+D+ EL+A K +++D
Sbjct: 1120 IAELQE---DFESEKASRNK----AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 866 ------LMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREG 919
L + LE++ E +++ + Q + + LE+ +++ EQ K+ K N+ E
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRF---KANL-----EK 1224
Query: 920 QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA 979
K+ +E ++L+ + + + E E K K + +++++ K E + L+ +L ++ +
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELAEKAS 1283
Query: 980 KLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE 1039
KL+ EL+N + L + EK K ++ A+ DA S LE+ ++ E L E R++
Sbjct: 1284 KLQNELDNVSTLLEEAEK----KGIKFAK-------DAAS-LESQLQDTQELLQEETRQK 1331
Query: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
LN +S ++L ++ LQE Q +E+E+ L++++L + + K+
Sbjct: 1332 LN--LSSRIRQLEEEKNSLQE----QQEEEEEARKNLEKQVLALQSQLADTKKK------ 1379
Query: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
V D E E+ K+K L +D L LE+ + +K K LQ++L +
Sbjct: 1380 --VDDDLGTIESLEEAKKK------LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
L + + ++ S L K K D+ E+KS+ + E + +
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLL-------------AEEKSISARYAEERDRAEAEA 1478
Query: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
K+T+AL A+ ++EAL K E E Q +
Sbjct: 1479 REKETKALSLARA---------------------------LEEALEAK----EEFERQNK 1507
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
QL + L S + E E ++++ +E + T+ E L+ E + A E
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399
+ +K + ++ ++E E+K + L KQ+ +L +L++ ++ A++S
Sbjct: 1568 NMQAMKAQFERDLQT----RDEQNEEKKRL--LIKQVRELEAELED--ERKQRALAVASK 1619
Query: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
+K + K +L Q++ + D + K+ Q+ D+ + E + F Q + +
Sbjct: 1620 KKMEIDLK-DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 1460 VKE--------LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK 1511
K+ LQ+Q EL S E + + ++EL + K + D+K ++E
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQE--RDELADEITNSASGKSALLDEKRRLEA 1736
Query: 1512 KESNLETELKSQTARIMELEDHITQKTIEIESLNEVL----------KNYNQQKDIEHKE 1561
+ + LE EL+ + + + L D + T+++++LN L N QQ + ++KE
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L KLQ + + K + I LE ++ ++ +LE + KE N V+ E++
Sbjct: 1797 LKAKLQELEGAVKSK------FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS---ELN 1678
LK + ++E E + A+ ++ +K A KQL Q+EE EE+ + S EL+
Sbjct: 1851 LKEIFMQVEDE--RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Query: 1679 TKLQERE---REVHILEEKLK 1696
+ E REV L+ +L+
Sbjct: 1909 DATEANEGLSREVSTLKNRLR 1929
Score = 194 bits (492), Expect = 1e-48
Identities = 239/1151 (20%), Positives = 523/1151 (45%), Gaps = 131/1151 (11%)
Query: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473
EEL+ K +E + K++ E++E + ++ EE+ I +Q ++
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ-------------LQA 898
Query: 474 SEEQIAKLQKLHEKELARKE--QELTKKLQTREREFQEQMKVAL--EKSQSEYLKISQEK 529
E A+ +++ + A+K+ +E+ L++R E +E+ ++ +K +++ +E+
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 530 EQQESLALEELELQKKAILTESENKLRDLQQE---AETYRTRILELESSLEKSLQENKNQ 586
+E A ++L+L+K +E K++ +++E E ++ ++ + +E + E +Q
Sbjct: 959 LDEEEGARQKLQLEK----VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 587 ---SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643
++ A +L +NK I+ + E+ K E ++ + + A KL Q ++
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA--KRKLDGETTDLQDQIA 1072
Query: 644 KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQT--ELESLSSELSEVLK--- 698
+L+ + ++ K L K KE Q + +++TL K + + EL++ +EL E +
Sbjct: 1073 ELQAQIDELKLQLAK-KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 699 -ARHKLEEELSVLKDQTDKMKQELEAKMD------EQKNHHQQQVDSIIKEHEVSIQRTE 751
+R+K E++ L ++ + +K ELE +D E + +Q+V + K E + E
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
++D + L+E + L++ + NLE + + E + ++ + ++ V Q ++ +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
+ K + Q+ +L K+ + + R+ L ++ ++++ ELD V L+++ E
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ-------NELD----NVSTLLEEAE 1300
Query: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
K+ + + SL ES+L+D T+++L E+ QK + ++L
Sbjct: 1301 KKGIKFAKDAASL----ESQLQD-------TQELLQEETR--------QKLNLSSRIRQL 1341
Query: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN-TAL 990
+++S+ EE E KN EK++ L+ +L D + K+ +L +L
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQV-----------LALQSQLADTKKKVDDDLGTIESL 1390
Query: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE--VHRRELNDVISIWE 1048
E ++K+ +A+ L A D + + + +++++ LT H+R++ + +
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450
Query: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
KK +Q E + I +E+++ AE + EKE + EE ++
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAR--------EKETKALSLARALEEALE---AK 1499
Query: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
E + Q KQ A + L + + ++ +LE K L++Q+ E++ EE +
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELE-------KSKRALEQQVEEMRTQLEELE 1552
Query: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
++ + Q++K+ E+ ++ ++++ E K+L + +L+ E
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE-----AELED 1607
Query: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
E K L S K L + K ++ ++ + + +L+AQ++ E
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEA 1664
Query: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
S + Q +E E ++KS++A+I L E + ++ + +Q E IT
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 1349 SENIN-------AVTLMKEELKEKKVEISSLSKQL--TDLNVQLQNSISLSEKEAAISS- 1398
S ++ + ++EEL+E++ + L+ + T L V N+ +E+ AA S
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 1399 -LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALE----QVDDWSNKFSEWKKKAQSRF 1453
R+Q + + EL ++Q+L V + K ISALE Q+++ + ++ + A
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE 1513
+ + +KE+ +Q+E + + A + EQ+ + Q ++ + E E++ ++
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE----EAEEEATRANASR 1900
Query: 1514 SNLETELKSQT 1524
L+ EL T
Sbjct: 1901 RKLQRELDDAT 1911
Score = 193 bits (491), Expect = 1e-48
Identities = 244/1146 (21%), Positives = 502/1146 (43%), Gaps = 164/1146 (14%)
Query: 287 RVKRQENLLKRCKETIQSHKEQCT--------------LLTSEKEALQEQLD---ERLQE 329
+V RQE L+ E + KE+ T L EK L EQL E E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 330 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL-----EMKEEEI 384
E+++ A+K +L L D ++ +E+ E+++ ++ K++M + ++ EEE
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEE-EEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 385 AQLRSRIKQMTTQG-----EE------------LREQKEKSERAA------FEELEKALS 421
A+ + +++++T + EE ++E+K +R A EE EKA +
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
A K + + ++++E++K EKT +QEL + K++ +D ++QIA+L
Sbjct: 1025 LA-KIRNKQEVMISDLEERLKKEEKT--------RQELEKAKRK-LDGETTDLQDQIAEL 1074
Query: 482 QKLHEK---ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
Q ++ +LA+KE+EL L + E L K+ + LK+ +E + Q + E
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDE-------TLHKNNA--LKVVRELQAQIAELQE 1125
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK------DLAV 592
+ E +KA ++E + RDL +E E +T ELE +L+ + + + ++K +L
Sbjct: 1126 DFE-SEKASRNKAEKQKRDLSEELEALKT---ELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 593 HLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE-- 650
LE E H +I M ++H T LE L Q + K + K + E + CE
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 651 --QEKETLLKDKEIIFQAHIEEMNEKT----------LEKLDVKQTELESLSSELSEVLK 698
Q+ + + K A ++E++ K EK Q EL+++S+ L E K
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 699 ARHKLEEEL----SVLKDQTDKMKQELEAKMDEQKNHHQ-QQVDSIIKEHEVSIQRTEKA 753
K ++ S L+D + +++E K++ Q ++ + ++E + + K
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQ 813
L+ Q+ L+ L + K + + +E+LE K+ + + S +L+ E+
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE----------EK 1411
Query: 814 TKAY---EEQLAQLQQKLLDLETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQDLM 867
AY E+ +LQQ+L DL + + + +E ++K + E + + +
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM--------------- 912
+ E + E E K SL + E LE + + Q KQ+ + E++
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 913 -----ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
+ Q E + ++E L +L A ED+ L + E+ ++ ++ +E +
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
L K++ + EA+L+ E + AL ++ K+K + D +++E K
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKM------------EIDLKDLEAQIEAANKA 1639
Query: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
+ E + ++ R+L + ++++L + EI Q +E E+++ L+ +IL
Sbjct: 1640 RDEVIKQL--RKLQAQMKDYQRELEEARASRDEIF-AQSKESEKKLKSLEAEIL------ 1690
Query: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
++ +E+ + + +EL +++ ++ ++L ++ +L+A + +LE +L +
Sbjct: 1691 -QLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
L ++ + + + +++ S + +D Q L+ +++ L++ K
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Query: 1208 KLSEELAIQLDICCKKTEALLE------AKTNELINISSSKTNAILSRISHCQHRTTKVK 1261
+ L+ + E LE A N+L+ + K I ++ + + K
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869
Query: 1262 EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE 1321
E + + +L+ QL + EE N S ++ +L++ + + ++ +L K
Sbjct: 1870 EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL---KN 1926
Query: 1322 ALQKEG 1327
L++ G
Sbjct: 1927 RLRRGG 1932
Score = 189 bits (480), Expect = 3e-47
Identities = 252/1204 (20%), Positives = 531/1204 (44%), Gaps = 128/1204 (10%)
Query: 869 QLEKQNSEMEQKVKSLTQVYE--SKLEDGNKEQEQTKQILVEKENMILQMREGQKK---E 923
Q+ +Q E++ K + L +V E +K+E +E E+ Q L+E++N++ + + + + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK--KKLLDQEAKL 981
E + +L+AK+ + + + E++ + +E++ + ++ + K+MQ ++ ++ LD+E
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
+++L+ + K K+ ++L + NS I + ++ +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE--------------------KKLME 1005
Query: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
D I+ +L ++ E+ + + +I+ ++E +++L++++ +KEE ++ L++
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIR-NKQEVMISDLEERL-----KKEEKTRQE--LEKAK 1057
Query: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
K D +LQ+Q+ + A ++ +LK L K E +L +L E L +
Sbjct: 1058 RKLDGETTDLQDQIAELQAQID-------ELKLQLAKKEEELQGALARGD--DETLHKNN 1108
Query: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
L + V EL +++ E+F+S K+S K+ K D S E + L EL LD
Sbjct: 1109 AL-----KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 1222 KKTEALL--EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
+ E E + EL +T ++I + R E L + +A L
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
+ + T N L++ + + + + +++ V E A EG + +EK S
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAA---- 1395
+L ++ V+ + EE ++K ++ + K L QLQ++ L ++E
Sbjct: 1284 -------KLQNELDNVSTLLEEAEKKGIKFA---KDAASLESQLQDTQELLQEETRQKLN 1333
Query: 1396 ISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ 1455
+SS +Q +EEK L +Q ++ L K+ ++ Q+ D K + +S
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 1456 HQNTVKELQ-IQLELKSKE-AYEKDEQI-NLLKEELDQQNKRFDCLKGEMEDDKSKMEKK 1512
+ +K+ + + L+ K AY+K E+ N L++ELD D + ++ + K +KK
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR-QVASNLEKKQKK 1452
Query: 1513 ESNLETELKSQTARIMELEDHITQKTIEIE----SLNEVLKNYNQQKDIEHKELVQKLQH 1568
L E KS +AR E D + E E SL L+ + K+ ++ Q
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 1569 FQELGEEKDN---RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625
++L KD+ V E E+ LE QV M+ +LE + EL+ + E ++A+
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 1626 EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY------KKGTESHLSELNT 1679
+ + E + + + + K I ++ +L +++E++ +Q KK E L +L
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVR-ELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631
Query: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK--TYEEK 1737
+++ + +E +K + Q++ R + A ++ A S+ +K + E +
Sbjct: 1632 QIEAANKA---RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Query: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797
I LQ L E+ + QE++E L + EA+ I L
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR-------IAQL 1741
Query: 1798 QEELEEKNKKYSLIVAQH----VEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
+EELEE+ L+ + ++ + + A+++ D+ ++ L+ + + L+
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN---KELK 1798
Query: 1854 QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV 1913
K++EL+ + K + + L +K +L+ E LE+ +E++ ++ +
Sbjct: 1799 AKLQELEGAV---KSKFKATISALEAKIGQLE------------EQLEQEAKERAAANKL 1843
Query: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
+ ++ +E + A++ K+++ K R+++ R L + ++
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 1974 EREEKIKQEQEDLELKHNSTLKQLMR-----EFNTQLAQKEQ------ELEMTIKETINK 2022
+RE E + + STLK +R F++ + + Q LE++ +T +K
Sbjct: 1904 QRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESK 1963
Query: 2023 AQEV 2026
+V
Sbjct: 1964 TSDV 1967
Score = 184 bits (467), Expect = 8e-46
Identities = 234/1115 (20%), Positives = 491/1115 (44%), Gaps = 178/1115 (15%)
Query: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
+++ +EAE++ + +L + + +E L + E Q+LQ EKKK+Q
Sbjct: 900 TELFAEAEEM--------RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA- 950
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEE---FDASLEEKDQYISVLQTQVS-LLKQ 233
I +L E+L ++ A++ LQ E +A +++ ++ I +L+ Q S +K+
Sbjct: 951 ----------HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 234 RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQEN 293
+ + L + E +A+ K N + E ++ D L++R+K++E
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ---EVMISD---------LEERLKKEEK 1048
Query: 294 LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD-------------LHMAE 340
+ ++ + + T L + LQ Q+DE +L K ++ LH
Sbjct: 1049 TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN 1108
Query: 341 KTKLITQL--------------RDAKNLIEQLEQDKGMVIAETKRQMHETLE-------- 378
K++ +L + ++N E+ ++D + K ++ +TL+
Sbjct: 1109 ALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1168
Query: 379 --MKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 436
+E+E+A+L+ +++ T E + + A EEL + L E ++ KA
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL-------EQAKRFKAN 1221
Query: 437 MDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--------- 487
+++ + +E T +E + L +VK E KK A++Q+LH K
Sbjct: 1222 LEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLD----AQVQELHAKVSEGDRLRV 1276
Query: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE---ELELQK 544
ELA K +L +L +E K ++ ++ SQ ++ QE L E +L L
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 545 K-AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
+ L E +N L++ Q+E E R + + +L+ L + K + D +E+ + K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-------------EKCE 650
+ E S + ++ AL +KL+ K + Q E++ L EK +
Sbjct: 1397 LL------KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450
Query: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
++ + LL +++ I + EE + E + K+T+ SL+ L E L+A+ + E + L
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEARE-KETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
+ M+ + +K D KN H+ ++++++AL+ Q+ ++ L+E +
Sbjct: 1510 RAD---MEDLMSSKDDVGKNVHE-------------LEKSKRALEQQVEEMRTQLEELED 1553
Query: 771 HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830
L+ + LE +++ + + ++ Q+ E+ + +Q+ +L+ +L D
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERD------LQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
+R L ++E KD+ +++A ++++QL K ++M+ + L + S
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 891 KLEDGNKEQEQTKQILVEKENMILQMRE-----------GQKKEIEI---LTQKLSAK-- 934
+ E + +E K+ L E ILQ++E +++ E+ +T S K
Sbjct: 1668 RDEIFAQSKESEKK-LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 935 --------EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
E I L EE E + N E ++ ++ ++ +TL +L + + +K +
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV-DTLNAELAAERSAAQKS-D 1784
Query: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET---NQKEQIESLTEVHRRELNDV 1043
N +L ++ K+ AK+ E+ A + +S LE +EQ+E + R N +
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK-ERAAANKL 1843
Query: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
+ EKK L+EI +Q++++ + + K+++ +++ +++ +EE +
Sbjct: 1844 VRRTEKK-------LKEIF-MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
+ + +LQ +L + L+++ + LK L +
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 178 bits (451), Expect = 6e-44
Identities = 242/1168 (20%), Positives = 511/1168 (43%), Gaps = 177/1168 (15%)
Query: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKE-EGVKQDTTLNELQEQLKQKSAHVNSLA 1126
+K+Q+++ LK +L C + W + VK + +E+L+ K + +
Sbjct: 808 KKQQQLSALK--VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVK 865
Query: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQL---VELKMLAEEDKRKVSELTSKLKTTDE 1183
+ +TK++ LE++E + L+E L EQL EL AEE + +++ +L+
Sbjct: 866 EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925
Query: 1184 EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT 1243
+ +S E+ N+ L+++ KK +A ++ +L ++
Sbjct: 926 DLESRVEEEEERNQILQNEK------------------KKMQAHIQDLEEQLDEEEGARQ 967
Query: 1244 NAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE 1303
L +++ + + K++E +L+ LE Q + +E+ + + + QL E+E
Sbjct: 968 KLQLEKVT-AEAKIKKMEEEILL-------LEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 1304 NQIKSM---KADIESLVTE-KEALQKEGGNQQQAASEKESC---ITQLKKELSENINAVT 1356
+ K++ + E ++++ +E L+KE +Q+ K T L+ +++E +
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISL-SEKEAAISSLRKQYDEEKC---ELLD 1412
+K +L +K+ E+ + D + N++ + E +A I+ L++ ++ EK +
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 1413 QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSK 1472
Q +DLS +++ L E LE D + E + K + + + ++E E K+
Sbjct: 1140 QKRDLSEELEALKTE----LEDTLDTTAAQQELRTKREQEVAELKKALEE-----ETKNH 1190
Query: 1473 EAYEKDEQ------INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
EA +D + + L E+L+Q KRF K+ +EK + LET+ K
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQA-KRF----------KANLEKNKQGLETDNKELACE 1239
Query: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
+ +VL+ + + + K+L ++Q E D E EK
Sbjct: 1240 V------------------KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
L+N++ ++ LE +K+ S E +L+ ++ L+ E+ KL L + Q
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL-NLSSRIRQ 1340
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
+K L + +E+EE+ +K E + L ++L + +++V ++ L ++ES +
Sbjct: 1341 --LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV---DDDLGTIESLEEAKK 1395
Query: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKT---YEEKISVLQRNLTEKEKL---LQRVGQEKE 1760
+ + A+ ++ E E+A + ++KT ++++ L +L + ++ L++ ++ +
Sbjct: 1396 KLLKDAEALSQRLE-EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
+ ++ + +Y E + + AEA+ E ++ L LEE A ++E
Sbjct: 1455 QLLAEEKSISARYAE---ERDRAEAEAREKETKALSLARALEE---------ALEAKEEF 1502
Query: 1821 GKNNIQAKQNLENVF---DDVQKTLQEKELTCQILEQKIKEL--------DSCLVRQKEV 1869
+ N Q + ++E++ DDV K + E E + + LEQ+++E+ D +
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 1870 HRVEMEELTSKYEKLQALQQMDGRN--------KPTELLEENTEEKSKSHLVQPKLLSNM 1921
R+E+ K + + LQ D +N K LE E++ K + M
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ------ER 1975
E DLE ++ A + + ++ K++ +LQ + K++Q+ELE + D+ E
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQM----KDYQRELEEARASRDEIFAQSKES 1678
Query: 1976 EEKIKQ-EQEDLELKHNSTLKQLMREFNTQ------------------LAQKEQELEMTI 2016
E+K+K E E L+L+ + R Q L +++ LE I
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 2017 KETINKAQEVEA--ELLESHQEETNQLL----------KKIAEKDDDLKRTAKRYEEILD 2064
+ + +E ++ ELL +T + + A+K D+ ++ +R + L
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 2065 AREEEMTAKVRD-LQTQLEELQKKYQQKLEQEENPGND----NVTIMELQTQLAQKTTLI 2119
A+ +E+ V+ + + L+ K Q EQ E + N + + +L + +
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
D + +++EQ+ R+K+ ++ +
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQL 1886
Score = 176 bits (447), Expect = 2e-43
Identities = 236/1136 (20%), Positives = 497/1136 (43%), Gaps = 150/1136 (13%)
Query: 141 QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQ 200
+ L +++ + G+ E+ +Q L EK L L Q++ + E+R L +
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL-QAETELFAEAEEMRARLAAKK 917
Query: 201 QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTK 260
Q + + + ++ +EE+++ +LQ + ++ +++ +D + Q + Q E T
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ-KLQLEKVTA 976
Query: 261 EENPESDGEPVV--EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT---SE 315
E + E ++ ED S E K E+ + C + +E+ L ++
Sbjct: 977 EAKIKKMEEEILLLEDQNSKFIKEK-----KLMEDRIAECSSQLAEEEEKAKNLAKIRNK 1031
Query: 316 KEALQEQLDERL-------QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
+E + L+ERL QELEK K E T L Q+ + + I++L+ + +A+
Sbjct: 1032 QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK----LQLAK 1087
Query: 369 TKRQMHETLEMKEEEIAQLRSRIK---QMTTQGEELRE----------QKEKSERAAFEE 415
+ ++ L ++E + +K ++ Q EL+E + EK +R EE
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 416 LEKA---LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 472
LE L T A+++L+ + ++++ ++K EEE K
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE-------------------TK 1188
Query: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
+ E QI +++ H L +EL+++L+ +R K LEK+ K E + +
Sbjct: 1189 NHEAQIQDMRQRHATAL----EELSEQLEQAKR-----FKANLEKN-----KQGLETDNK 1234
Query: 533 ESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE---LESSLEKSLQENKNQSKD 589
E LA E LQ+ + ESE+K + L + + ++ E L L + + +N+ +
Sbjct: 1235 E-LACEVKVLQQ--VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN 1291
Query: 590 LAVHLEAEKNKHNKEITVMVEKHKTELES-LKHQQDALWTEKLQVLK-----QQYQTEME 643
++ LE + K + K LES L+ Q+ L E Q L +Q + E
Sbjct: 1292 VSTLLEEAEKK-----GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 644 KLREKCEQEKETL--LKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH 701
L+E+ E+E+E L+ + + Q+ + + T +K+D +ESL ++LK
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLAD----TKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 702 KLE---EELSVLKDQTDKMKQELEAKMDE--QKNHHQQQVDSIIKEHEVSIQRTEKALKD 756
L EE ++ D+ +K K L+ ++D+ HQ+QV S
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS------------------ 1444
Query: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK-LDVFQSYQSATHEQTK 815
LE K+ D+ L E ++ + R+E E ++ K L + ++ + A E +
Sbjct: 1445 ---NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL-EAKE 1500
Query: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---MQQLEK 872
+E Q QL+ + DL + + + K V E+E K+ + +++ + Q+++L +Q E
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 873 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 932
+E ++++ +E L+ +++ E+ K++L+++ + E ++K+ +
Sbjct: 1561 AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKK 1620
Query: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL 992
E + L + E K +++ ++++++ +M++ ++ L++ + E+ + E
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE--LEEARASRDEIFAQSKES 1678
Query: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
+K K A++L++ Q A A E + E + +T + + +++L
Sbjct: 1679 EKKLKSLEAEILQL-QEELASSERARRHAEQERDELADEIT--NSASGKSALLDEKRRLE 1735
Query: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
+ +L+E +L+E++ + L + + + +N E+ + K D +L+
Sbjct: 1736 ARIAQLEE----ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 1113 EQLKQKSAHVNSL--------AQDETKLKAHLEKLEVDLNKSLKENTF-------LQEQL 1157
Q K+ A + L + L+A + +LE L + KE +++L
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
E+ M E+++R + +++ + + LK E++ + + +KL EL
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Score = 110 bits (276), Expect = 1e-23
Identities = 147/604 (24%), Positives = 269/604 (44%), Gaps = 96/604 (15%)
Query: 1603 TKKKELEHVNLSVKSKEEELKALEDRL------ESESAAKLAELKRKAEQKIAAIKKQLL 1656
TK K L L V +EEEL+A ++ L +++ +L E++RK +Q + +K +L
Sbjct: 839 TKVKPL----LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE--EKNIL 892
Query: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
++ + E + E + L K QE E +H LE + VE + I+ K +
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESR---VEEEEERNQILQNEKKKMQ 949
Query: 1717 AYT---EQEEADSQGCVQK------TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
A+ E++ + +G QK T E KI ++ + E + +EK+
Sbjct: 950 AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009
Query: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
E Q E K ++ +++ + MI L+E L+++ K Q +EK A
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK-----TRQELEK--------A 1056
Query: 1828 KQNLENVFDDVQKTLQE-----KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE 1882
K+ L+ D+Q + E EL Q L +K +EL L R + E K
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQ-LAKKEEELQGALARGDD-------ETLHKNN 1108
Query: 1883 KLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK---LLSNMEAQHNDLEFKL---AGAE 1936
L+ ++++ + EL E+ EK+ + + + L +EA +LE L A +
Sbjct: 1109 ALKVVRELQAQI--AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN-STLK 1995
+ K +E+ L+K L K H+ +++ +++ + EE +Q ++ K N K
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE--ETNQLLKKIAEKDDDLK 2053
Q + N +LA + + L+ E+ +K ++++A++ E H + E ++L ++AEK L+
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 2054 RTAKRYEEILDAREEEMTAKVRD---LQTQLEE----LQKKYQQKL-------------- 2092
+L+ E++ +D L++QL++ LQ++ +QKL
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 2093 -------EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
E+EE N ++ LQ+QLA D+K K + I +LE+ KK K
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLA-------DTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 2146 NVYA 2149
+ A
Sbjct: 1400 DAEA 1403
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 231 bits (588), Expect = 8e-60
Identities = 458/2379 (19%), Positives = 994/2379 (41%), Gaps = 340/2379 (14%)
Query: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66
QK+ + QQLQ + ++ +S+ ++++ T Q + D Q +
Sbjct: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
Query: 67 LRVPSVES---LFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123
+++ ++ ++ + + S+ +E + + E LN ++ + + D +
Sbjct: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTT 354
Query: 124 AEDLVGNSDSLNKEQLIQR---LRRMERSLSSYRGKYSE--------LVTAYQMLQREKK 172
A+ L+G +EQ++Q+ ++ M+ L++ + K + + T ++ +R K
Sbjct: 355 ADKLLGEL----QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 173 KLQ---GILSQSQDKSLRRIAELREEL-----QMDQQAKKHLQEEFDASLEE-----KDQ 219
Q I+ + + ++ R++ +LR EL Q Q K+ L + A +EE K +
Sbjct: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 220 YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
+ L++ ++ + MNV + + +L+ KE+ E G + E +
Sbjct: 471 MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS--QKEKLKEELGLILEEKCALQR 528
Query: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
LE L + + ++R ++TI + + +++ E + E K+L +
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVI--------AETKRQMHETLEMKEEEIAQLRSRI 391
+ ++ + K +E LE++K V+ AE +R + L EEE+++L+ +
Sbjct: 589 HEA----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644
Query: 392 K-QMTTQGEELRE-------------QKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
+ + E+L++ Q E S++ + EK + K + ++
Sbjct: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLK 703
Query: 438 DEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQ---KLHEKELAR 491
D Q + SEE + LQ+E+ ++QE + K + E+++ +LQ +L EK++
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE--KGTLEQEVQELQLKTELLEKQMKE 761
Query: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-LEELELQKKAILTE 550
KE +L +K E E + +K+ + LKI Q+E L L+ ++ + K + E
Sbjct: 762 KENDLQEKFAQLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
E ++ L +E E + + ++L +EK K+ V+ + + ++ +
Sbjct: 820 KEIEI--LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY-----ACLL 872
Query: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
K K +LE K++Q+ + KL+ L ++ ++++ + K ++ D++ F A E
Sbjct: 873 KVKDDLEDSKNKQELEYKSKLKALNEELH--LQRINPTTVKMKSSVF-DEDKTFVAETLE 929
Query: 671 MNE-------KTLEKLDVKQTELESLS---SELSEVLKARHK----LEEELSVLKDQTDK 716
M E + +EKL+V + E LS S+LSE LK +H L EE+ LK + ++
Sbjct: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
Query: 717 MK---QELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRTEKALKDQINQLELLLKERDKHL 772
+ +ELE ++ + + Q D+ + + + T + + ++++ E K +
Sbjct: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
Query: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQLAQLQQKLLD 830
E + EN+ + + +L + S T E + + +LQ++L
Sbjct: 1050 VEDKVSFENMTVGEESKQEQL--------ILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
Query: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS----------EMEQK 880
L++E+ L Q +EAQ+ + H QV++ M+ EK + E+K
Sbjct: 1102 LKSEQNDLRLQ---MEAQRICLSLVYSTHVDQVREYMEN-EKDKALCSLKEELIFAQEEK 1157
Query: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
+K L ++++ +L+ + ++T +I ++++ +E Q L + +
Sbjct: 1158 IKELQKIHQLELQ--TMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCS------V 1209
Query: 941 LNEEYETKFK-----------------NQEKKMEKVKQKAKEMQE---TLKKKLLDQEAK 980
L E Y K N++ +++ + + ++ QE TL K+ ++ K
Sbjct: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
Query: 981 LKKELENTALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLE---TNQKEQIESLT 1033
L + Q+ + +F + L + I ++ LE N K ++ SL
Sbjct: 1270 LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ 1329
Query: 1034 EVHRRELNDVISIWE---KKLNQQAEELQEIHEIQ---LQEKEQEVAEL----------- 1076
++ + +L + + E L QQ +E ++ +E + LQ++ Q V+E
Sbjct: 1330 DLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSV 1389
Query: 1077 ------KQKILLFG-CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Q+ + G C K+ ++ I + E GVK++T + +L E+ Q+
Sbjct: 1390 VITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIV 1449
Query: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
+ A ++ E+ KENT +Q + ++++ +E+ KL FQ+ +
Sbjct: 1450 SMSIAFAQQTELSRISGGKENTASSKQ---AHAVCQQEQHYFNEM--KLSQDQIGFQTFE 1504
Query: 1190 SSHEKSNKSLEDKSLEFKKLSEE------------------LAIQLDICCKKTEALLEAK 1231
+ K + + S E + +E L I ++ K ++
Sbjct: 1505 TVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564
Query: 1232 TNELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL---TEEQN 1286
++ I++SS + +L+ R V++ + T +A +RQ+ E+Q
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE 1624
Query: 1287 TLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKESCI-- 1341
L ++ QL ++ + D E+LV+E+E + + E Q A ++ C
Sbjct: 1625 QLQEEIKRLNRQLAQRSS------IDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
Query: 1342 ------TQLKKELSENINAVTLMKEELKEKKVEI--SSLSKQ------------------ 1375
TQ E + T ++EL K ++ LS +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 1376 -----------------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
+ D + + Q+S SL + A +S++ EE + D+ S
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE-SIPS 1797
Query: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
+ + + I+ +V + + S+ ++ T+ +EL + + + + A EK
Sbjct: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEK- 1856
Query: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHIT 1535
L E + + + + + K + + +++ LK Q R+ E
Sbjct: 1857 -----LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE 1911
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE---KDNRVKEAE-------E 1585
Q +E+ V+ Y +K + +++ +K L +E NR++E E E
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE 1645
+ L Q +MKAE +++L + ++ E++ +++ + ++ L+ E
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
Query: 1646 QKIAAI------KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
++++ K L + ++ + +K E L+ + +RE E + +++++ +E
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
Query: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK 1759
+ +VPR T + E + +KT +K S L L KE+L + + +
Sbjct: 2092 ---QQLKVVPRFQPISEHQTREVEQLANHLKEKT--DKCSEL---LLSKEQLQRDIQERN 2143
Query: 1760 EETVSSHFEMRCQYQERLIK-LEHAEAKQHEDQ-SMIGHLQEELEEKNKKYSLIVAQHVE 1817
EE F +R Q L++ +H A + + + S+ LQ E + ++K I +
Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQ 2203
Query: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
E Q ++ LEN ++VQ+ + E+ + +++EL+ ++ ++ + +ME+L
Sbjct: 2204 LE------QFREELENKNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKL 2253
Query: 1878 TSKYEKLQALQQMDGR---NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
++ A+ D K ++++E E + + KL ++ ++ K+
Sbjct: 2254 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN---KVIE 2310
Query: 1935 AEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNST 1993
+ E + L +I L D +++ ++E+E L E EK++QE ++ K +
Sbjct: 2311 EKNELIRDLETQIECLMSDQECVKRNREEEIEQL-----NEVIEKLQQELANIGQKTSMN 2365
Query: 1994 LKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-----ELLESHQEETNQLLKKIAEK 2048
L E ++ + +L++ I E + Q+VE +++ +ETN + ++ ++
Sbjct: 2366 AHSLSEEADS----LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE 2421
Query: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--------KKYQQKLEQEENPGN 2100
LKR + E+I E + + L EL+ K + + + N
Sbjct: 2422 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2481
Query: 2101 DNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
+I+ L+T+L Q + +S L+ + +QI +++++
Sbjct: 2482 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2520
Score = 223 bits (569), Expect = 1e-57
Identities = 438/2257 (19%), Positives = 926/2257 (41%), Gaps = 375/2257 (16%)
Query: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162
N+L L+ S S ++S++E++ + L KE I+ LR+ E+ + + EL
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE--IEILRQEEKEKGTLEQEVQELQL 750
Query: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-MDQQAKKHL---QEE---FDASLE 215
++L+++ K+ + L + + + L++E + ++ K H QEE F S++
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 216 EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275
K + SV + ++ +L + N D+ + QL + E K+ N S E
Sbjct: 811 SKSKD-SVWEKEIEILIEE------NEDLKQQCIQLNEEIE---KQRNTFSFAE------ 854
Query: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL-LTSEKEALQEQLDERLQELEKIK 334
K E Q ++ + L + K+ ++ K + L S+ +AL E+L L++I
Sbjct: 855 ---KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-----HLQRIN 906
Query: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
+ K+ + + D + E LE G V+ + ++ E LE+ + E +L R+ +
Sbjct: 907 PTTVKMKSSVFDE--DKTFVAETLEM--GEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
Query: 395 TTQ-----------GEELREQKEKSERAAFE--ELEKALS--TAQKTEEARRKLKAEMDE 439
+ Q EE++ K++ E+ + ELE ++ A+ + ++ + +D
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
Query: 440 QIKTIEKTSE------------------EERISLQQ----ELSRVKQEVVDVMKKSSEEQ 477
+ + +E E+++S + E S+ +Q ++D + ++E
Sbjct: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082
Query: 478 IAKLQKLHEKELARKEQELTKKLQT----------------------REREFQEQMKVAL 515
+ + E + +KE + K Q + RE+ E K
Sbjct: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
Query: 516 EKSQSEYLKISQEKEQQESLALEELELQ---------------------KKAILTESENK 554
S E L +QE++ +E + +LELQ +KA+ E
Sbjct: 1143 LCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
Query: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
L+ L Y T L+ E + E + +N ++ + + E + E+ E T
Sbjct: 1203 LQTLCSVLGEYYTPALKCEVNAE----DKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
Query: 615 ELESLKHQQDAL----------WTEKLQVLKQQYQTE---MEKLREKCEQEKETLLKDKE 661
L + + + L W ++ +K ++ E E+ + T L+D +
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR--------HKLEEELSVLKDQ 713
+ ++ + + + KL+ + ELESL S L + LK H L++ L + +
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 714 TDKMKQELEAKM-DEQKNHHQQQVDSIIKEH-EVSIQRT-EKALKDQINQLELLLKERDK 770
T +++ + E S +K++ + +I+ + E +K++ N ++LL K+ +
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE 1438
Query: 771 HLKEH--------------------------------QAHVENLEADIKRSEGELQQASA 798
L+E QAH + +E +L Q
Sbjct: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQI 1498
Query: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLL----------------------DLETERI 836
F++ E+ K ++L + +++L ++
Sbjct: 1499 GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 837 LLTKQVA--EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
+ +Q E+ D +L ++ Q++D+ Q+L +Q E +Q + L Q + ++E
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 895 GNKEQEQTKQIL------------VEKENMILQMREGQKKEIEILTQKLSAKEDSI--HI 940
++QEQ ++ + ++ EN++ + +E+E L Q A + + +
Sbjct: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
Query: 941 LNEEYETKFKNQEK-KMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKE 996
N +T+ N+ + ++E+ K KE+ E + ++L E ++ N L++ +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL--NDVISIWEKKLNQQ 1054
+ A + E + GI D S+ +++ S E + + + ++ +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
Query: 1055 AEELQEIHEIQLQEK-EQEVAELKQKIL---LFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
+ ++I + K +E EL Q+++ G E + N+E+ + + + +
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL--MLNISSRLQAAVEK 1856
Query: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
L E + + S+ + +T+L + + + +SLK L+E+L E+ R
Sbjct: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL-------HEESRA 1909
Query: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
+L +L + + +++K+ +L +EL +C LEA
Sbjct: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCASNRLQELEA 1964
Query: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
+ ++ + +LSR KEA+ +E QL Q TE+ +
Sbjct: 1965 EQQQI-----QEERELLSR----------QKEAM---KAEAGPVEQQLLQETEKLMKEKL 2006
Query: 1291 SFQ-QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELS 1349
Q QA ++ + Q+K+++ D+E V+ L++E + ++ + + +++
Sbjct: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066
Query: 1350 ENINAVTLMKEELKEK-KVEISSLSKQLTDL-NVQLQNSISLSEKEAAISSLRKQYDEEK 1407
+ ++ + +E ++ + EI L +QL + Q + E E + L+++ D K
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD--K 2124
Query: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK-----E 1462
C +L + L ++ E+++ + E ++ +H V+
Sbjct: 2125 C------SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178
Query: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
L++QL+ + K+++I L+E+L+Q + E+E+ ++++ LE + K
Sbjct: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQ-------FREELENKNEEVQQLHMQLEIQKKE 2231
Query: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYN------------------QQKDIEHKEL-- 1562
T R+ ELE ++E L +K + Q+K++E +L
Sbjct: 2232 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2291
Query: 1563 -VQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELE----TKKKELEHVNLSVK 1616
V KLQ Q+L DN+V +E E I LE Q+ + ++ E +++E+E +N ++
Sbjct: 2292 QVTKLQ--QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2349
Query: 1617 SKEEELKALEDRLESESAAKLAE----LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
++EL + + S +A L+E LK + + IA +K L Q E + ++
Sbjct: 2350 KLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIA--EKLALEQQVETANEEMTFMKN 2406
Query: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA---------------- 1716
L E N K+ + +E+ L+ + +SVE QS +P ++ NVA
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQS----IPENSVNVAIDHLSKDKPELEVVLT 2462
Query: 1717 ----------AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE-KLLQRVGQEKEETVSS 1765
Y + E + +G + E ++ L+ ++ K+ +L Q Q K+
Sbjct: 2463 EDALKSLENQTYFKSFEENGKGSI-INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2521
Query: 1766 HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
FE Q++++ L+ ++ +++ +Q E ++ K+ Q + E + NI
Sbjct: 2522 QFETE-MLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQ-DNQTISSEPERTNI 2578
Query: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885
Q L D++ + L LE ++ E+ + L+ +KE + + + K +KL
Sbjct: 2579 QNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLL 2636
Query: 1886 ALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944
LQ+ ++G K ++ +EK +S L + E H++ E +G E + L
Sbjct: 2637 ELQKLLEGNEK-----KQREKEKKRSPQDVEVLKTTTELFHSNEE---SGFFNELEALRA 2688
Query: 1945 EIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT 2003
E V + +L + K + + E+L KE + +K + D + L L +E T
Sbjct: 2689 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2748
Query: 2004 QLAQKEQEL---EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
++ + ++ + IK + + A + + L S +T Q+L K A +L+
Sbjct: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQS------ 2802
Query: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
+ EE+T + ++E++Q+ + ++ E+
Sbjct: 2803 ---ECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2836
Score = 214 bits (544), Expect = 1e-54
Identities = 393/1898 (20%), Positives = 805/1898 (42%), Gaps = 290/1898 (15%)
Query: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL--------STAQKTEE 428
LEM E E+A + I+++ + EE+R +E E A+ ++
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 429 ARRKLKAEMDEQIKT-IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI--AKLQKLH 485
ARR E DE ++ +E T + +++ +Q + + + + + S+ + AK Q L
Sbjct: 217 ARR----EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
Query: 486 EKELARKEQELTKKLQTREREF-------QEQMKVALEKSQSEYLKISQEKEQQESLALE 538
++ ++ L + Q ++ +F QE++KV E Q + ++ S ++E QE +
Sbjct: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETII 331
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEA 596
E EL K I E E K +L+ + T + EL+ + + QE KN +L + E
Sbjct: 332 E-ELNTKII--EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER 388
Query: 597 EKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKET 655
+ ++ K++ VE EL+ H+ T+ +Q ++Q+ Q ++E+LR E E +
Sbjct: 389 QSSEEIKQLMGTVE----ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS------ELSEVLKARHKLEEELSV 709
+++ K+ + + H+ +M E + L S S+ ++ + A ++L +L
Sbjct: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
Query: 710 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Q +K+K+EL + E+K Q+Q++ +++E S ++ ++A + I + E L E
Sbjct: 505 TNSQKEKLKEELGLIL-EEKCALQRQLEDLVEELSFSREQIQRA-RQTIAEQESKLNEAH 562
Query: 770 KHLKEHQAHVENLEADI-----------KRSEGELQQASAKLDVFQSYQSATHEQ-TKAY 817
K L + VE+L+A+I + E E+ KL++ + ++A ++ ++
Sbjct: 563 KSL----STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ 618
Query: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL--------MQQ 869
E +L +L+ +LL E + K+ E+E H+I ++ L QQ
Sbjct: 619 EAELERLRTQLLFSHEEELSKLKEDLEIE------------HRINIEKLKDNLGIHYKQQ 666
Query: 870 LEKQNSEMEQKVKS--------LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK 921
++ +EM QK+++ +T+ + LE + Q + + E M LQ+ E Q
Sbjct: 667 IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ- 725
Query: 922 KEIEILTQKLSAK---EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978
KEIEIL Q+ K E + L + E K ++K +++K +++ + +L E
Sbjct: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE--AENSILKDE 783
Query: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ--KEQIESLTEVH 1036
K +++ +SQ+E+ ++ +S + +E N+ K+Q L E
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE--I 1094
++ N S EK +ELQE + L+ K+ ++ L + + + +N+E +
Sbjct: 844 EKQRN-TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ-DETKLKAHLEKLEVDLNKSLKENTFL 1153
+ VK +++ + + ++ + + + D T+L +EKLEV + L+ + L
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTEL---MEKLEVTKREKLELSQRL 959
Query: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
+ L+E+ K+K E++ +EE +SLK EK SL + LE ++
Sbjct: 960 SD-------LSEQLKQKHGEIS----FLNEEVKSLK--QEKEQVSLRCRELEI-IINHNR 1005
Query: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK--VKEALLIKTCTV 1271
A + C + +LL+ ++ ++S +S+++ +K V++ + + TV
Sbjct: 1006 AENVQSCDTQVSSLLDG----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 1272 SELEAQLRQL-------TEEQNTLNISFQQATHQLEEKENQIKSMKADIE---------- 1314
E E++ QL ++++L + +L+++ N +KS + D+
Sbjct: 1062 GE-ESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICL 1120
Query: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE----KKVEIS 1370
SLV Q ++ +EK+ + LK+EL + +E++KE ++E+
Sbjct: 1121 SLVYSTHVDQV----REYMENEKDKALCSLKEEL------IFAQEEKIKELQKIHQLELQ 1170
Query: 1371 SLSKQLT-DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
++ Q T D L + + + + A+S + + C +L + + K + +++K
Sbjct: 1171 TMKTQETGDEGKPLH--LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKE 1228
Query: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
++ + + + ++ V++ Q + + E+ ++ +L+ L
Sbjct: 1229 NSGDYISE----------NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLS 1278
Query: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNL---ETELKSQTARIMELEDHITQKTIEIESLNE 1546
+ + G+ + D K+E E NL ETE S +++ LED ++ SL
Sbjct: 1279 K-------IWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL-- 1328
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+D+E +L +++Q + L ++KE E+ + +AE+ +K
Sbjct: 1329 --------QDLEKTKLEEQVQELESLISSLQQQLKETEQ----------NYEAEIHCLQK 1370
Query: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
L+ V+ S + L +S ++ + +KK + +E E
Sbjct: 1371 RLQAVSES---------TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
Query: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
K + + L + QE+ LEE++ V S S ++ E +
Sbjct: 1422 VKEETNIVKLLEKQYQEQ------LEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSK 1475
Query: 1727 QG---CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Q C Q+ Q E + ++G + ETV F+ K
Sbjct: 1476 QAHAVCQQE---------QHYFNEMKLSQDQIGFQTFETVDVKFKEE-------FKPLSK 1519
Query: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
E +H + ++ + ++K L +++ + + ++ +++ D++ +
Sbjct: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR-----QSIHDEISVSSM 1574
Query: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903
+ + E++++++ LVRQ + H+ E L + + Q+ D E+ N
Sbjct: 1575 DASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
Query: 1904 TEEKSKSHLVQPKLLSNME-AQHNDLE----FKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
+ +S + L+S E +LE LAG E+ +L + Q
Sbjct: 1635 RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNG-----N 1689
Query: 1959 EHQQELE---ILKKEYDQERE----EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ- 2010
E+Q E+E +KE D++ E E + E+ L+ +N LK L+ T A +E
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
Query: 2011 -ELEMTIKETINKAQ---------EVEAELL----ESHQEETNQLLKKIAEKD---DDLK 2053
+ I + +K+Q E EA + E H T++ + + D +D+
Sbjct: 1750 GRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809
Query: 2054 RTAKRYEE----------------ILDAREEEMTAKVRD-LQTQLEELQKKYQQKLEQEE 2096
+K EE +D EE+ + LQ +E+L + + Q E
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE 1869
Query: 2097 NPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134
+ VT EL + ++ ++S ++E RE++H
Sbjct: 1870 HA---KVTQTELMRESFRQKQEATESLKCQEELRERLH 1904
Score = 212 bits (540), Expect = 3e-54
Identities = 487/2240 (21%), Positives = 912/2240 (40%), Gaps = 409/2240 (18%)
Query: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
S +K ++++ E S+SS ++ Q+ ++ ++ Q L R A +
Sbjct: 1554 SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
Query: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252
R+ ++ ++ ++ LQEE + Q S+ +L+ +R R ++ LK L L
Sbjct: 1614 RQ-MERQREDQEQLQEEIKRLNRQLAQRSSI--DNENLVSERERVLLEELEALKQL-SLA 1669
Query: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312
+ ++ + N + + E+ V+ +Q K +E L R E + +L
Sbjct: 1670 GREKLCCELRNSSTQTQNGNENQGEVE-----EQTFKEKE--LDRKPEDVPPE-----IL 1717
Query: 313 TSEKEALQEQLDERLQEL-EKIKDLHMAEKT---------KLITQLRDAKNLIEQLEQDK 362
++E+ ALQ+ + L+ L E +K E+T ++ + + +LI + E +
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAE- 1776
Query: 363 GMVIAETKRQMHET-LEMKEEEIAQL------RSRIKQMTTQGEELREQKEKSERAAFEE 415
A K +HE + +E I R+ I + EE E ++ R+ F
Sbjct: 1777 ----ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832
Query: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE------ERISLQQELSRVKQEVVDV 469
E + +L+A +++ ++ I +TS + + L +E R KQE +
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892
Query: 470 MKKSSEEQIAKLQKLHEKELARKEQ--ELTK----------KLQTREREFQEQMKVALEK 517
+K E + ++LHE+ AR++ EL+K + ER+ QE+ + +++
Sbjct: 1893 LKCQEELR----ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI-IDR 1947
Query: 518 SQSEYLKIS---QEKEQQESLALEELEL---QKKAILTESENKLRDLQQEAETYRTRILE 571
+ E L S QE E ++ EE EL QK+A+ E+ + L QE E LE
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007
Query: 572 LESSLEKSLQENKNQSKDLAV----------HLEAEKN-------KHNKEITVMVEKHKT 614
++ EK + + Q K L + LE EKN + N+ + +EK +
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
Query: 615 ELESL----KHQQDALWTEKLQVLKQQ------------YQT-EMEKL----REKCEQEK 653
L+ +H++D ++ +++Q L+QQ +QT E+E+L +EK ++
Sbjct: 2068 FLDEQAIDREHERD-VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE--------------------SLSSEL 693
E LL +++ Q I+E NE+ +EKL+ + ELE SL +L
Sbjct: 2127 ELLLSKEQL--QRDIQERNEE-IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQL 2183
Query: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE-- 751
A + E+E++ L++Q ++ ++ELE K +E + H Q ++ KE +Q E
Sbjct: 2184 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKKESTTRLQELEQE 2242
Query: 752 -KALKDQINQLELLLKERDKHLKEHQAHVENLEADI-KRSEGELQQASAKLDVFQSYQSA 809
K KD + +L L +KE D + Q + A I + E E+ Q + ++ Q
Sbjct: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302
Query: 810 THEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ 869
T + K EE+ + + DLET+ L +++ E K++ E++ ++ L Q+
Sbjct: 2303 TTDN-KVIEEK----NELIRDLETQIECL---MSDQECVKRNREEEIEQLNEVIEKLQQE 2354
Query: 870 LEKQNSEMEQKVKSLTQ-----------------VYESKLEDGNKEQEQTKQILVE---K 909
L + SL++ E ++E N+E K +L E K
Sbjct: 2355 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2414
Query: 910 ENMILQMREGQKKEIEILTQKLSAKEDSI-----HILNEEYETKFKNQEKKMEKVKQKA- 963
N + Q K+E E + + S E+S+ H+ ++ E + E ++ ++ +
Sbjct: 2415 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2474
Query: 964 -KEMQETLKKKLLDQEAKLKKELENTA----LELSQ---------KEKQFNAKMLE---- 1005
K +E K +++ E +L +LE+T LEL+Q ++ QF +ML+
Sbjct: 2475 FKSFEENGKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV 2533
Query: 1006 --------------MAQANSAGISDAVSRLETNQ-------KEQIESLTEVHRRELNDVI 1044
++Q + + + NQ + I++L ++ EL I
Sbjct: 2534 NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI 2593
Query: 1045 SIWEKKLNQQAEELQEIHEIQLQEKEQ-EVAE----------LKQKILLFGCEKEEMNKE 1093
S ++++ ++ E+H + EKEQ E+AE L+ + LL G EK++ KE
Sbjct: 2594 SALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKE 2653
Query: 1094 ITWLKE--EGVKQDTTLNELQEQ------LKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
+ E +K T L E+ L+ A + + K EKL+ +L
Sbjct: 2654 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713
Query: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLE 1205
T LQ+ L +++ E K K+S L + +T +E S K+ + L
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE----------SKKACMFEPLP 2763
Query: 1206 FKKLSEELAIQLDICCK-----KTEALLEAKTNELINISSS-KTNAILSRISHCQHRTTK 1259
K LS+ +A Q D K +T +L IN+ S + + IS + K
Sbjct: 2764 IK-LSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2822
Query: 1260 VKEA-----LLIKTCTVSELEAQLRQ-------LTEEQNTLNISFQQATHQLEEKENQIK 1307
++E L +++ +SE E R+ L EE TL Q L KE
Sbjct: 2823 MQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC----LRSKEGSSI 2878
Query: 1308 SMKADIESLVTEKEALQKEGGNQQQA----------------ASEKESCITQLKKELSEN 1351
A ++ T + G + Q E ES K++
Sbjct: 2879 PELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGL 2938
Query: 1352 INAVTLMKEELKEKKVEISSLSKQL----TDLNVQLQNSISLSEKEA---AISSLRKQYD 1404
+ AV + +++ SL++ D ++Q + L E++A ISSL+
Sbjct: 2939 LRAV-------HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLIT 2991
Query: 1405 EEKCELLDQVQDLSFKVDTLSK---EKISALEQV---------------------DDWSN 1440
+ + + +V D S ++ S E + AL+QV D
Sbjct: 2992 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVG 3051
Query: 1441 KFSEWKKKAQSRFTQHQNTVKELQ------IQLELKSKEAYEKDEQINLLKE-------- 1486
+ +++ Q + ++Q ++ LQ + E+++ A +I L +E
Sbjct: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ 3111
Query: 1487 ---ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543
E + Q K+ L EM+ + S M+ + + L+ +L S+ + EL+ + Q +E+E+
Sbjct: 3112 ELLEYNIQQKQSQML--EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3169
Query: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
+ + ++ + E+ K L + + K++ E LE + + E
Sbjct: 3170 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3229
Query: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
K+ELE + S++S+++ L LE + KQLL++ ++K
Sbjct: 3230 DKEELEDLKFSLESQKQRNLQLNLLLEQQ--------------------KQLLNESQQKI 3269
Query: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
E + ++ LSE Q R E+ +L E K S TL + + A + +
Sbjct: 3270 ESQRMLYDAQLSE----EQGRNLELQVLLESEKVRIREMSSTL---DRERELHAQLQSSD 3322
Query: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE------RL 1777
Q E+ + LQ+ L EK + + E E+ + R Q ++ +
Sbjct: 3323 GTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382
Query: 1778 IKLE-----HAEAKQHEDQSMIGHLQEELEEKNKK-YSLIV----AQHVEKEGGKNNIQA 1827
++ E + K HE QS + LQ +LEEK ++ Y L + Q + +E K ++
Sbjct: 3383 LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3442
Query: 1828 KQNLE-------NVFDDVQKTLQEKELTCQILEQKI--KELDSCLVRQKEV--------H 1870
++ E N+ + +L +L+QKI + +S + E+ H
Sbjct: 3443 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3502
Query: 1871 RVEM--EELTSKYEKLQALQQMDGRNKPTELLEEN----TEEKSKSHLVQPKLLSNMEAQ 1924
+EM ++L KLQ L Q E ++ +E ++Q + L+ + +
Sbjct: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE 3562
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQE 1984
L ++L ++ L + L +E ++ K EE+I+ ++
Sbjct: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK-----LEEQIRWYRQ 3617
Query: 1985 DLELKHNSTLKQLMREFNTQ-LAQKEQELEMTIKETINKA-QEVEAELLESHQEETNQLL 2042
+ NS+ L N + + E+E+ K T+ K+ + EAE+ + E N L
Sbjct: 3618 TGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3677
Query: 2043 KKIAEKDDD---LKRTAKRY 2059
+ D + LKR +Y
Sbjct: 3678 LQTLSPDSEHVTLKRIYGKY 3697
Score = 209 bits (533), Expect = 2e-53
Identities = 488/2430 (20%), Positives = 982/2430 (40%), Gaps = 419/2430 (17%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
K+ K+++S ++L+ + +A + S T++ S G S +SF
Sbjct: 984 KQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFG 1043
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD--M 120
++ ++ V S + E S +E L+ + L + +SS + P + +
Sbjct: 1044 EESKIMVEDKVSFENMTVGEE----SKQEQLIL----DHLPSVTKESSLRATQPSENDKL 1095
Query: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKK----KLQG 176
E L + L + QR+ LS + + V Y +++K K +
Sbjct: 1096 QKELNVLKSEQNDLRLQMEAQRI-----CLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
Query: 177 ILSQSQD-KSLRRIAELREELQMDQQAKKH------LQEEFDASLEEKDQYISVLQTQVS 229
I +Q + K L++I +L + Q+ L + ++ E+ Y LQT S
Sbjct: 1151 IFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF--LQTLCS 1208
Query: 230 LLKQRLRNGPMNVDVLK---PLPQLEPQAEVFTKEENPE-SDGEPVVEDGTSVKTLETLQ 285
+L G LK E + ++ E+PE D V+D + + TL
Sbjct: 1209 VL------GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ--ENMHTLL 1260
Query: 286 QRVKRQEN---LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ---ELEKIKDLHMA 339
+V + N +L+ I + L +E L ++ E L ++ ++D+ +
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
K+KL + K +E+ Q+ +I+ ++Q+ ET + E EI L+ R++ ++
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS---- 1376
Query: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
+ + + S AQ+T +K +D I+ + +E ++ + L
Sbjct: 1377 ----ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLL 1432
Query: 460 SRVKQEVVD--VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT-----REREFQEQMK 512
+ QE ++ V K IA Q+ ++ ++ Q +E+ + +MK
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 513 VALE------------KSQSEYLKISQEKEQQESLAL------EELELQKKAILTESENK 554
++ + K + E+ +S+E + L ++ K +LT SE
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE-- 1550
Query: 555 LRDLQQEAETYRTR------ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
++ + +T+ R I + L N+ Q +D+ L + +H + ++
Sbjct: 1551 --EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELL 1608
Query: 609 VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHI 668
+ H ++E + Q+ L E+++ L +Q L ++ + E L+ ++E + +
Sbjct: 1609 RQAHMRQMERQREDQEQL-QEEIKRLNRQ-------LAQRSSIDNENLVSERERVLLEEL 1660
Query: 669 EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
E + + +L + EL + S++ + + ++EE+ + + + D+ +++ ++
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ-TFKEKELDRKPEDVPPEILSN 1719
Query: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
+ + Q+ ++ + + + + +T A+++ I + L + +R + ++ + I R
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS-------SKSQSSASLIWR 1772
Query: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYE----------------EQLAQLQQKL---- 828
SE E AS K V + + T E +Y E+ +L Q+L
Sbjct: 1773 SEAE---ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829
Query: 829 -----LDLETERILLTKQVAEVEAQKK------DVCTELDAHKIQVQDLMQQLEKQNSEM 877
+D E E ++L A +K + ++L+ K+ +LM++ +Q E
Sbjct: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEA 1889
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI------------------------ 913
+ +K ++ E +L + ++ +EQ L + E +I
Sbjct: 1890 TESLKCQEELRE-RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRL 1948
Query: 914 ----------LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
LQ E ++++I+ + LS +++++ E + + +K+ K K +
Sbjct: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+ E ++ L Q L+ ++E + E++ N +++++ Q N A LE
Sbjct: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA--------LEK 2060
Query: 1024 NQKEQIESLTE--VHRRELNDVISIWEKKLNQQAE---ELQEIHEIQLQEKEQEVAELKQ 1078
++ + L E + R DV +KL QQ + Q I E Q +E EQ LK+
Sbjct: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE 2120
Query: 1079 K------ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK-QKSAHVNSL-AQDET 1130
K +LL KE++ ++I EE K + + EL++ L + H ++ A+ E
Sbjct: 2121 KTDKCSELLL---SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL 2177
Query: 1131 KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
L+ L+ +++ KE T L+EQL + + E +V +L +L+ +E +
Sbjct: 2178 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2237
Query: 1191 SHEKSNKSLEDKSLEFKKLSEELAI-QLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249
E+ NK +D + +KL LAI + D + + +L K ++I + + + +
Sbjct: 2238 ELEQENKLFKD---DMEKLG--LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2292
Query: 1250 ISHCQH--RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307
++ Q + T + + K + +LE Q+ L +Q + + ++ QL E +++
Sbjct: 2293 VTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2352
Query: 1308 ----------------------SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345
S+K ++ ++ EK AL++ Q + A+E+ + + +
Sbjct: 2353 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ----QVETANEEMTFMKNVL 2408
Query: 1346 KELSENINAVTLMKEELKEKK---------------VEISSLSKQLTDLNVQL-QNSISL 1389
KE + +N +T LK ++ V I LSK +L V L ++++
Sbjct: 2409 KETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2468
Query: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
E + S + L ++ L V E +Q+ D + +
Sbjct: 2469 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2528
Query: 1450 QSRFTQHQNTVKE-----LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Q + Q V+E L Q++L++ + Y K Q N + + + +R +
Sbjct: 2529 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN---QTISSEPERTNI------- 2578
Query: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
++ + +E L +++ + T RI ELE + + + E ++ +K++ KE +
Sbjct: 2579 -QNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI--AEKNVLEKE--K 2633
Query: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624
KL Q+L E + + +E E+K + +V EL +E N EL+A
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN--------ELEA 2685
Query: 1625 LEDRLESESA-AKLAELKRKAE--QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
L R ES + A+LA K KAE Q+ +K+ ++ +++ Q + HL+E KL
Sbjct: 2686 L--RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR----DHLAEAKEKL 2739
Query: 1682 Q--EREREVHILEEKL------------KSVESSQSETLIVPRS-------AKNVAAYTE 1720
E+E E + E K KS+ S TL + S KN
Sbjct: 2740 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799
Query: 1721 -QEEADSQGCVQ--KTYEEKISVLQ------------RNLTEKEKLLQR----VGQEKEE 1761
Q E S+ + + EKI +Q R+++E E L + V KEE
Sbjct: 2800 LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEE 2859
Query: 1762 TVSSHFEMRCQYQER---LIKLEHAEAKQHEDQSM------------IGHLQ-------- 1798
+ ++C + + +L H++A Q + + H Q
Sbjct: 2860 CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG 2919
Query: 1799 --EELEEKNKKY-----SLIVAQHVEKEGGKNNIQAKQNLENVFDD-----VQKT----L 1842
EE E + L+ A H E +Q E+ + D +Q+ L
Sbjct: 2920 RGEESESATDSFPKKIKGLLRAVHNE------GMQVLSLTESPYSDGEDHSIQQVSEPWL 2973
Query: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY-----EKLQALQQMDGRNKPT 1897
+E++ + +K+L + + Q+E + + + E L ALQQ+ +
Sbjct: 2974 EERKAYINTISS-LKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032
Query: 1898 ELLEENTEEKSKSHLVQPKLLSNMEA--QHNDLEFKLAGA---EREKQKLGKEIVRLQKD 1952
L TE + LL+ +E Q +E++ A + +++ L EI L
Sbjct: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQ 3092
Query: 1953 LR----MLRKEHQQEL---EILKKEYDQEREEKIKQEQEDLELKHNSTL--------KQL 1997
+ L++E + E E+L+ Q++ + ++ + E +K +T K +
Sbjct: 3093 MNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMV 3152
Query: 1998 MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK 2057
+ E ++LAQ + ELE T+K AQ + LE+ + E ++ +D L K
Sbjct: 3153 VAELKSELAQTKLELETTLK-----AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 3207
Query: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQK-KYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
+ E+ A E+E R + EEL+ K+ + +++ N ++L L Q+
Sbjct: 3208 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN--------LQLNLLLEQQK 3259
Query: 2117 TLISDSKLKEQEFR---------EQIHNLE 2137
L+++S+ K + R EQ NLE
Sbjct: 3260 QLLNESQQKIESQRMLYDAQLSEEQGRNLE 3289
Score = 207 bits (527), Expect = 9e-53
Identities = 427/2210 (19%), Positives = 919/2210 (41%), Gaps = 342/2210 (15%)
Query: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQM-LQREKKKLQGI 177
D+D + + + L K +L ++++ +E +SS + + E Y+ + +K+LQ +
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV 1375
Query: 178 LSQSQDKSLR--RIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL 235
+ SL + + Q +++ D ++E ++ +T + L ++
Sbjct: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435
Query: 236 RNGPMNVDVLKPLPQLE----------------------PQAEVFTKEENPESDGEPVVE 273
+ +V K + + QA ++E + + +
Sbjct: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ 1495
Query: 274 DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKI 333
D +T ET+ + K + K + + H ++ L S+ + E D L E
Sbjct: 1496 DQIGFQTFETVDVKFKEE---FKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE-- 1550
Query: 334 KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQ 393
++ +KT ++ Q + + + + RQ L + EE++ +R ++
Sbjct: 1551 -EMFSKDKTFIVRQ---------SIHDEISVSSMDASRQ----LMLNEEQLEDMR---QE 1593
Query: 394 MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ--IKTIEKTSEEE 451
+ Q +E ++ E +A ++E+ ++ +E ++L ++ ++ I SE E
Sbjct: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
Query: 452 RISLQQ-----ELSRVKQEVV--DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE 504
R+ L++ +LS +E + ++ S++ Q + +E KE+EL +K +
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Query: 505 REFQEQMKVALEKSQSEYLKISQE-----------------------KEQQESLAL---E 538
E + AL+K+ + LKI E + Q S +L
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRS 1773
Query: 539 ELELQKKAILTESENKLRD----------LQQEAETYRTRILELESSLEKSL-------Q 581
E E K+ + E ++ D + + +++ E + L + L
Sbjct: 1774 EAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGT 1833
Query: 582 ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641
E ++++L +++ + +++ + + ++LE K Q L E + ++Q TE
Sbjct: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFR--QKQEATE 1891
Query: 642 ----MEKLREKCEQE---KETL---LKDKEIIFQAHIEE-------MNEKTLEKLDVKQT 684
E+LRE+ +E +E L L E + + +E + EKT + +D +
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKT-DIIDRLEQ 1950
Query: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
EL S+ L E+ + +++EE +L Q + MK E +++Q +++ E +
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA-GPVEQQLLQETEKLMKEKLEVQ 2009
Query: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
++ L+ Q+ LE+ ++E+ E + D+++ L++ K+ F
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 805 SYQSATHEQTK-AYEEQLAQLQQKLLDLETERILLTKQVAEVEA------QKKDVCTELD 857
Q+ E + +++++ +L+Q+L + + + Q EVE +K D C+EL
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 858 AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR 917
K Q+Q + ++++N E+E KLE +E EQ +LVE +
Sbjct: 2130 LSKEQLQ---RDIQERNEEIE------------KLEFRVRELEQA--LLVEDRKHFGAVE 2172
Query: 918 EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
+ +E+ +L A+ D+I + E + N E+++E+ +++ + E +++ +
Sbjct: 2173 AKPELSLEV---QLQAERDAI----DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2225
Query: 978 EAKLKKELENTALELSQKEKQFNAKM--LEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
E + KKE EL Q+ K F M L +A S +S + + QI EV
Sbjct: 2226 EIQ-KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284
Query: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT 1095
+LN+ ++ KL QQ + + I+ EK + + +L+ +I ++E + +
Sbjct: 2285 EIDQLNEQVT----KLQQQLKITTDNKVIE--EKNELIRDLETQIECLMSDQECVKRN-- 2336
Query: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHV--------NSLAQDETKLKAHLEKLEVDLNKSL 1147
+EE ++Q LNE+ E+L+Q+ A++ +SL+++ LK L+ + +
Sbjct: 2337 --REEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
++ E++ +K + +E K+++LT +L + E +S++ S+
Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2451
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
K EL + L TE L++ N+ S + N S I+ ++ LL
Sbjct: 2452 KDKPELEVVL------TEDALKSLENQTY-FKSFEENGKGSIIN--------LETRLLQL 2496
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT-------EK 1320
TVS + +L Q ++ + Q T L++K I +++ +E V +
Sbjct: 2497 ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK---IVNLQKIVEEKVAAALVSQIQL 2553
Query: 1321 EALQKEGG---NQQQAASEKESC----ITQLKK-ELSENINAVTLMKEELKEKKVEI-SS 1371
EA+Q+ + Q +SE E + QL++ EL +I+A+TL EL+ + VE+ +S
Sbjct: 2554 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2613
Query: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSL-----RKQYDEEK-------------CELLDQ 1413
L + + + +N + +K + L +KQ ++EK EL
Sbjct: 2614 LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2673
Query: 1414 VQDLSF--KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
++ F +++ L E ++ ++ + K +K Q + + LQ L
Sbjct: 2674 NEESGFFNELEALRAESVATKAELASYKEK----AEKLQEELLVKETNMTSLQKDLSQVR 2729
Query: 1472 KEAYEKDEQINLLK--EELDQQNKRFDCLKGEM--EDDKSKMEKKESNLETELKSQTARI 1527
E E++++L+ +E + Q + C+ + + KS + + L+ +QT +I
Sbjct: 2730 DHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQI 2789
Query: 1528 MELEDHIT---QKTIEIESLNEVLKNYNQQ----KDIEHKELVQ-KLQHFQE---LGEEK 1576
+ I Q E + E++ + ++ +++ E++ + +H E L E
Sbjct: 2790 LVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEH-------------------------- 1610
V+ +E+ TL+ + ++++ + EL H
Sbjct: 2850 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2909
Query: 1611 ---VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK----------QLLS 1657
+++ + + EE ++ D + L + + Q ++ + Q +S
Sbjct: 2910 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2969
Query: 1658 QMEEKEEQYKKGTESHLSELNTKLQ-EREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
+ +E + T S L +L TK+Q +RE EV+ + +S + E L+
Sbjct: 2970 EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-------- 3021
Query: 1717 AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE-KEETVSSHFEMRC-QYQ 1774
+Q + + + + +++ L T+ LL + Q +E+ V M C Q
Sbjct: 3022 --LQQVFLEERSVLLAAFRTELTAL--GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA 3077
Query: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK-QNLEN 1833
+R L +A + L+ E E + L+ +K+ +Q + ++++
Sbjct: 3078 DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKD 3137
Query: 1834 VFDDVQKTLQEKELTCQILEQKIK----ELDSCL------VRQKEVHRVEMEELTSKYEK 1883
++Q+ L +++ L+ ++ EL++ L +++ E R+E+++ T +
Sbjct: 3138 RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL 3197
Query: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
L + + K EL +EK+K + + +E DL+F L E +KQ+
Sbjct: 3198 LNDTLASE-QKKSRELQWALEKEKAKLGRSEERDKEELE----DLKFSL---ESQKQR-N 3248
Query: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK--------IKQEQEDLELKHNSTLK 1995
++ L + + L E QQ++E + YD + E+ + E E + ++ S+
Sbjct: 3249 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 1996 QLMREFNTQLAQKEQE--------LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047
RE + QL + E +KE + +E + ++E E L +
Sbjct: 3309 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368
Query: 2048 KDDDLKRTAKRYEEILDAREEEMTA---KVRDLQTQLEELQKKYQQKLEQ 2094
+ +++ + + + L +E T K+ +LQ+++E+LQ++ ++K +Q
Sbjct: 3369 RQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3417
Score = 203 bits (517), Expect = 1e-51
Identities = 389/2037 (19%), Positives = 850/2037 (41%), Gaps = 289/2037 (14%)
Query: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374
+++ + QL LQ+ + KD M E +L Q + + +QL+ + + +
Sbjct: 202 QRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA 261
Query: 375 ETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSE----RAAFEELEKALSTAQKTEEAR 430
+ L+ K+ Q+ + +Q+ Q L + ++K E + +F + + + ++ ++
Sbjct: 262 DLLQAKQ----QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVE 317
Query: 431 RKLKAEMDEQIKTIE----KTSEEERISLQQE---------LSRVKQEVVDVMKKSSEEQ 477
K E+ E+ IE K EEE+ +L+ + L +++++V +K+ E +
Sbjct: 318 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEIK 374
Query: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
KL+ + K+ R+ E K+L E Q++ K I Q EQ+ L
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN----HKDSQFETDIVQRMEQETQRKL 430
Query: 538 EEL-----ELQKKAILTESENKLRDLQQEAETYRTRIL-ELESSLE--KSLQENKNQSKD 589
E+L E+ + I+ + +R + E +TR E+E++L ++ N++Q K
Sbjct: 431 EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
Query: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL---R 646
+ V + E+ + ++ ++ E LK + + EK L++Q + +E+L R
Sbjct: 491 MNVAI--------NELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSR 541
Query: 647 EKCEQEKETLLKDKEIIFQAH--IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLE 704
E+ ++ ++T+ + + + +AH + + + E + ++ E +EV + KLE
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 705 ----EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI-- 758
E+ +VL + + ELE + H++++ + ++ E+ + + LKD +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 759 ---NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Q++ L E + ++ Q +NL I + + + S D+ QS ++ E+
Sbjct: 662 HYKQQIDGLQNEMSQKIETMQFEKDNL---ITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
Query: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
+L + + L E E+ L ++V E++ + + + ++ + +Q+ QLE +NS
Sbjct: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
Query: 876 EMEQKVKSLTQV--------YESKLEDGNKEQEQTKQILVEKE-NMILQMREGQKKEIEI 926
++ + K+L + E +L + + ++K + EKE ++++ E K++
Sbjct: 779 ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
Query: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
L +++ + ++ + +E ++ +++ + + +++++ K+ L+ ++KLK E
Sbjct: 839 LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 987 NTALE------------LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
L+ + ++K F A+ LEM + ++ + +LE ++E++E
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE---- 954
Query: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
L+Q+ +L E QL++K E++ L +++ EKE+++
Sbjct: 955 ----------------LSQRLSDLSE----QLKQKHGEISFLNEEVKSLKQEKEQVSLRC 994
Query: 1095 TWLKEEGVKQDTTLNELQ-EQLKQKSAHVNSLAQDETKLKAHLEKLEVD-LNKSL-KENT 1151
L + +N + E ++ V+SL + + + V +NKS +E+
Sbjct: 995 REL-------EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
Query: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ E V + + ++ K +L + + SL+++ N L+ + K
Sbjct: 1048 IMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 1212 ELAIQLD---ICC-----------------KKTEALLEAKTNELINISSSKTNAILSRIS 1251
+L +Q++ IC +K +AL K ELI K L +I
Sbjct: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK-EELIFAQEEKIKE-LQKIH 1165
Query: 1252 HCQHRTTKVKEA--------LLI---KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
+ +T K +E LLI + E L+ L + E
Sbjct: 1166 QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE 1225
Query: 1301 EKENQ----IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
+KEN ++ +++ E + Q+ +E+ + + L+ LS+ T
Sbjct: 1226 DKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQT 1285
Query: 1357 ------LMKEELKEKKVEISSLSKQLT---DLNVQLQNSIS-------------LSEKEA 1394
+E L +++ E S+ Q+T D++V ++ +S + E E+
Sbjct: 1286 DGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345
Query: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
ISSL++Q E + ++ L ++ +S+ + VD S ++ ++ T
Sbjct: 1346 LISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVD------SVVITESDAQRT 1399
Query: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLK-------EELDQQNKRFDCLKGEMEDDKS 1507
+ + + I ++ + E+ N++K E+L+++ + ++
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459
Query: 1508 KMEKKESNLETELKSQTAR-IMELEDH------ITQKTIEIESLNEVLKNYNQQKDIEHK 1560
++ + E S+ A + + E H ++Q I ++ V + + E K
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE----EFK 1515
Query: 1561 ELVQKL-QHFQE--LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
L ++L +H +E L + + E+++ +LT+ +++S ++ + +++S
Sbjct: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
Query: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
+L E++LE + +L ++ +Q +++ + QME + E ++ + + L
Sbjct: 1576 ASRQLMLNEEQLE-DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ-LQEEIKRL 1633
Query: 1678 NTKLQER----------EREVHILE--EKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
N +L +R ERE +LE E LK + + E L +N + T+ +
Sbjct: 1634 NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCC--ELRNSSTQTQNGNEN 1691
Query: 1726 SQGCVQKTYEEK------ISVLQRNLTEKEKLLQRVGQE--------------KEETVSS 1765
++T++EK V L+ + LQ+ EET+
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 1766 HF------EMRCQYQERLIKLEHAEAK----QHE------DQSMIGHLQEELE------- 1802
H + Q LI AEA HE D+S+ + ++
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
K + ++Q + + G +N E + + + E + + + +L+
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNME 1922
V Q E+ R E K E ++L K E L E E+S++ LS E
Sbjct: 1872 KVTQTELMR---ESFRQKQEATESL-------KCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 1923 AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE------ 1976
+ + ER+ Q+ I RL+++L + QELE +++ +ERE
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQEL-LCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 1977 EKIKQEQEDLELKHNSTLKQLMR---EFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033
E +K E +E + ++LM+ E Q + +L+ +K +E + +E
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ-KL 2092
QE+ +L+ + +++ L++ ++ + LD E+ + + +E+QK QQ K+
Sbjct: 2041 EQEKNTELM-DLRQQNQALEKQLEKMRKFLD---EQAIDREHERDVFQQEIQKLEQQLKV 2096
Query: 2093 EQEENPGNDNVT--IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
P +++ T + +L L +KT S+ L +++ + I + ++K E V
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Score = 194 bits (493), Expect = 8e-49
Identities = 408/1957 (20%), Positives = 801/1957 (40%), Gaps = 387/1957 (19%)
Query: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRME--RSLSSYRGKYSELVTAYQMLQREKKKLQ 175
S+ S+ E L +E Q+ E + R + E A + L E K +
Sbjct: 1862 SETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 176 GILSQSQD------KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS 229
G++ D + ++ ++ + L+ + + +E +A ++ + +L Q
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 230 LLKQRLRNGPMNVDVLKPLPQL-EPQAEVFTKEENPESDGEPVVEDGTSVKTLET-LQQR 287
+K GP+ +L+ +L + + EV + E D + VK LE ++++
Sbjct: 1982 AMKAEA--GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK------QVKALEIDVEEQ 2033
Query: 288 VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ 347
V R L + + ++Q L + E +++ LDE+ + E +D+ E KL Q
Sbjct: 2034 VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Query: 348 L--------------RDAKNLIEQLEQ--DKGMVIAETKRQMHETLEMKEEEIAQLRSRI 391
L R+ + L L++ DK + +K Q+ ++ + EEI +L R+
Sbjct: 2094 LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Query: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
+++ E+A E K + E L+ ++ + I++ E+E
Sbjct: 2154 REL--------------EQALLVEDRKHFGAVEAKPEL--SLEVQLQAERDAIDR-KEKE 2196
Query: 452 RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ--- 508
+L+++L + ++E+ E + ++Q+LH +L +++E T +LQ E+E +
Sbjct: 2197 ITNLEEQLEQFREEL--------ENKNEEVQQLH-MQLEIQKKESTTRLQELEQENKLFK 2247
Query: 509 ---EQMKVALEKSQS-----------EYLKISQEKEQQESLALEELELQKKAILTESENK 554
E++ +A+++S + ++ +I QEKE + E++ ++ + ++NK
Sbjct: 2248 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2307
Query: 555 L----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
+ +L ++ ET ++ + ++++ +E Q ++ L+ E ++ ++
Sbjct: 2308 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2367
Query: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
E +SLKHQ D + EKL L+QQ +T E++ KET K
Sbjct: 2368 SLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNVLKETNFK------------ 2414
Query: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ-- 728
MN+ T EL SL E V K + E ++V D K K ELE + E
Sbjct: 2415 MNQLT--------QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466
Query: 729 KNHHQQ----------------------QVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
K+ Q Q++S + ++ + + K +KD Q + +
Sbjct: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526
Query: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
K + Q VE A S+ +L+ Q Q+ + E + + L QL++
Sbjct: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2586
Query: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-----------------QDLMQQ 869
+L ++ LT +++E+E+Q ++ T L K QV Q L++
Sbjct: 2587 D--ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2644
Query: 870 LEKQNSEMEQK--------VKSLTQVYESKLEDG-----------------------NKE 898
EK+ E E+K +K+ T+++ S E G K
Sbjct: 2645 NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2704
Query: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK--- 955
++ +++LV++ NM +K++ + L+ ++ + IL +E ET+ + +K
Sbjct: 2705 EKLQEELLVKETNMT-----SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMF 2759
Query: 956 ----MEKVKQKAKEMQETLK-------KKLLDQEAKLKKELEN--TALELSQKEKQFNAK 1002
++ K A + TLK ++L + A ++ L++ ++ E+++ QF K
Sbjct: 2760 EPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK 2819
Query: 1003 MLEMAQANSAGISDAVSR----LETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAE 1056
+ +M + ++A I D SR ET ++E ++ + L VI K
Sbjct: 2820 IEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIP 2879
Query: 1057 ELQEIHEIQLQE--KEQEVAELKQKILL-----FGCEKEEMNKE---------------I 1094
EL Q +E ++ Q I L F E +E +
Sbjct: 2880 ELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLL 2939
Query: 1095 TWLKEEGVK------------QDTTLNELQEQ-LKQKSAHVNSLAQDE---TKLKAHLEK 1138
+ EG++ +D ++ ++ E L+++ A++N+++ + TK++ E
Sbjct: 2940 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 2999
Query: 1139 LEVDLNKSLKE-NTFLQEQLVELKMLAEEDKRKV-----SELTSKLKTTD---------E 1183
D ++S + + + E L+ L+ + E++ + +ELT+ L TTD +
Sbjct: 3000 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA-LGTTDAVGLLNCLEQ 3058
Query: 1184 EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT----EALLEAKTNELI--N 1237
Q ++ + + L+ K+ LSE A+ + +K E E + EL+ N
Sbjct: 3059 RIQEQGVEYQAAMECLQ-KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3117
Query: 1238 ISSSKTNAILSRI--SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
I ++ + ++ S + R T+++E L + V+EL+++L Q E T + +
Sbjct: 3118 IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH 3177
Query: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
+LE ++K K D L+ + A +++ + Q A EKE +E
Sbjct: 3178 LKELEAFRLEVKD-KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD------ 3230
Query: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
KEEL++ K + S ++ LN+ L Q L+E + I S R YD + E +Q
Sbjct: 3231 ---KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE--EQG 3285
Query: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL----- 1469
++L +V L EK+ E + +EL QL+
Sbjct: 3286 RNLELQV-LLESEKVRIREMSSTLDRE-------------------RELHAQLQSSDGTG 3325
Query: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
+S+ ++ + L+++L++++ R L E E K K++ QT + ME
Sbjct: 3326 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE--KYKLD----------SLQTRQQME 3373
Query: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
+ + +KT++ E + N + + EL K++ Q EEK +V + L
Sbjct: 3374 KDRQVHRKTLQTE------QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK-----LD 3422
Query: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRK---AEQ 1646
LE Q L+ +E + L + K E + L L + L + + +Q
Sbjct: 3423 LEGQ------RLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
KI + E KE Y K L E+N E+ ++ +KL+ V S+
Sbjct: 3477 KI---------EGETKESNYAK-----LIEMNGGGTGCNHELEMIRQKLQCV---ASKLQ 3519
Query: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV-GQEKEETVSS 1765
++P+ A + E AD +E +Q N+ E LQ++ GQ+ EE
Sbjct: 3520 VLPQKASERLQF---ETAD---------DEDFIWVQENIDEIILQLQKLTGQQGEEPSLV 3567
Query: 1766 HFEMRC-QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI------VAQHVEK 1818
C ERL++ ++ + GH+ + EEKN +++ + + +
Sbjct: 3568 SPSTSCGSLTERLLR---------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3618
Query: 1819 EGGKNN-----IQAKQNLENVFDDVQKTLQEKELTCQ 1850
G++N + N+E + ++ ++LT Q
Sbjct: 3619 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQ 3655
Score = 129 bits (325), Expect = 2e-29
Identities = 297/1443 (20%), Positives = 604/1443 (41%), Gaps = 184/1443 (12%)
Query: 5 LKQKISEEQQQLQQALAPAQAS-SNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+K+ EE +QL + + Q +N T M + S +E+ D + + A
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH--SLSEEADSLKHQLDVVIAEKLAL 2390
Query: 64 KLQLRVPSVESLF-RSPIKESLFRSS--SKESLVRTSSRESLNRLDL---DSSTASFDPP 117
+ Q+ + E F ++ +KE+ F+ + ++E RES+ ++ +S + D
Sbjct: 2391 EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHL 2450
Query: 118 SDMDSEAEDLVGNSDSLN---------------KEQLIQRLRRMERSLSSYRGKYSELVT 162
S E E +V D+L K +I R+ + S+ K EL
Sbjct: 2451 SKDKPELE-VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2509
Query: 163 AYQMLQ--REKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQY 220
Y+ ++ +E+ + + + Q + +L++I E + + Q + +E+ A + +Q
Sbjct: 2510 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY-AKFCQDNQT 2568
Query: 221 ISVL--QTQVSLLKQRLRNGPMNVDVLK---PLPQLEPQA-----EVFTKEENPESDGEP 270
IS +T + L Q LR + D+ + +LE Q + ++E E +
Sbjct: 2569 ISSEPERTNIQNLNQ-LREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2627
Query: 271 VVEDGTSVKTLETLQQ--RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ 328
V+E + L+ L + K++E KR + ++ K L S +E+
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES------GFFN 2681
Query: 329 ELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR-QMHETLEMKEEEIAQL 387
ELE ++ +A K +L + A+ L E+L ++ ET + + L + +A+
Sbjct: 2682 ELEALRAESVATKAELASYKEKAEKLQEEL------LVKETNMTSLQKDLSQVRDHLAEA 2735
Query: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
+ ++ + + E E +E + FE L LS + ++ LK Q I
Sbjct: 2736 KEKLSILEKEDET--EVQESKKACMFEPLPIKLSKSIASQ-TDGTLKISSSNQTPQILVK 2792
Query: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF 507
+ +I+LQ E S +EV +++ + +E+ I K+Q+LH E+ E + +T +RE
Sbjct: 2793 NAGIQINLQSECS--SEEVTEIISQFTEK-IEKMQELHAAEILDMESRHISETETLKRE- 2848
Query: 508 QEQMKVALEKSQSEYLK-ISQEKEQQESLALEELELQKKAILTE--SENKLRDLQQEAET 564
+ V L K + LK + Q +E ++ EL E S + D Q
Sbjct: 2849 -HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYL 2907
Query: 565 YRTRILELESSLEKSLQENKNQS--KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
++ ++ S E+ S K + L A N+ + +++ + + Q
Sbjct: 2908 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2967
Query: 623 QDALWTEKLQVLKQQYQTEMEKLRE---KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
W E+ ++ Y + L++ K + ++E + D Q+H + + L
Sbjct: 2968 VSEPWLEE----RKAYINTISSLKDLITKMQLQREAEVYDSS---QSHESFSDWRGELLL 3020
Query: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
++Q LE S VL A + E D + LE ++ EQ +Q ++ +
Sbjct: 3021 ALQQVFLEERS-----VLLAAFRTELTALGTTDAVGLLNC-LEQRIQEQGVEYQAAMECL 3074
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K S+ +AL Q+N ++ LK + K Q E LE +I++ + ++ + +
Sbjct: 3075 QKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ---ELLEYNIQQKQSQMLEMQVE 3131
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKL----LDLETERILLTKQVAEVEAQKKDVCTE 855
L + + EQ + + +A+L+ +L L+LET K + E+EA + +V +
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191
Query: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
D + + D + +K++ E++ ++ E +E E K L ++ LQ
Sbjct: 3192 TDEVHL-LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3250
Query: 916 MR---EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
+ E QK+ + QK+ ++ E + + + +E K + +EM TL
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL-- 3308
Query: 973 KLLDQEAKLKKELENTALE------------LSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
D+E +L +L+++ L + +KQ K + + + +
Sbjct: 3309 ---DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDS 3365
Query: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ--LQEKEQEVAELKQ 1078
L+T Q Q+E +VHR+ L E++ N + ++ ++HE+Q +++ ++++ E +Q
Sbjct: 3366 LQTRQ--QMEKDRQVHRKTLQT-----EQEANTEGQK--KMHELQSKVEDLQRQLEEKRQ 3416
Query: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN----------SLAQD 1128
++ E + + +G+ Q+ EL+ + K++S + SL D
Sbjct: 3417 QVYKLDLEGQRL---------QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3467
Query: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188
T+ +K+E + KE+ + + L+E+ ++ + KL+ + Q L
Sbjct: 3468 RTRNWVLQQKIEGET----KESNYAK--LIEMNGGGTGCNHELEMIRQKLQCVASKLQVL 3521
Query: 1189 --KSSHEKSNKSLEDKSLEFKKLS-EELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
K+S ++ +D+ + + + +E+ +QL + + + +
Sbjct: 3522 PQKASERLQFETADDEDFIWVQENIDEIILQL----------------QKLTGQQGEEPS 3565
Query: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE----- 1300
++S + C T E LL + +EL + QLTEE+N L + Q+
Sbjct: 3566 LVSPSTSCGSLT----ERLLRQN---AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3618
Query: 1301 --EKENQIK---SMKADIESLV-TEKEALQKEGGNQQQAASEKESCITQLKKELSENINA 1354
++N + + A+IE+++ +EKE +E Q++ E+ + +LK EL +
Sbjct: 3619 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3678
Query: 1355 VTL 1357
TL
Sbjct: 3679 QTL 3681
Score = 124 bits (310), Expect = 1e-27
Identities = 194/870 (22%), Positives = 379/870 (43%), Gaps = 122/870 (14%)
Query: 1357 LMKEELKEKKVEISSLSKQLTDLNVQL--QNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
+M+ EL K+ EI L+++L ++ V + L E EAAI KQ D +L +
Sbjct: 159 MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAI----KQRDGIITQLTANL 214
Query: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL----------Q 1464
Q + D +E + EQ +F + + R + H +T +L Q
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 1465 IQLELKSK--EAYEKDE-----QINLLKE-----ELDQQNKRFDCLKGEMEDDKS----- 1507
QLE + E Y+K + QI+ L+E E++Q K + K E+++ ++
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 1508 -----KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
+ EKK L+ +L + + EL++ I QK EI+++ L N Q++ +E+
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
Query: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622
Q + +EL ++++++ + E I+ Q K LE + EL+ + +++
Sbjct: 395 KQLMGTVEEL-QKRNHKDSQFETDIVQRMEQETQRK--LEQLRAELDEMY------GQQI 445
Query: 1623 KALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQ 1682
++ L + A++ E+K + + ++ + S + E+Q K + ++ELN KLQ
Sbjct: 446 VQMKQELIRQHMAQMEEMKTRHKGEMENALRSY-SNITVNEDQIKLMNVA-INELNIKLQ 503
Query: 1683 EREREVHILEEKL------KSVESSQSETLIVPRS--------AKNVAAYTEQEEADSQG 1728
+ + L+E+L K Q E L+ S A+ A E + ++
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE--------RLIKL 1780
+ + K ++ + + KE L K E ++++++ + E R+ +
Sbjct: 564 SLSTVEDLKAEIVSASESRKELEL------KHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
Query: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
+ AE ++ Q + H +EEL + + + ++EK I KQ ++ + +++ +
Sbjct: 618 QEAELERLRTQLLFSH-EEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
Query: 1841 TLQ----EKE--LTCQ---ILE-QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA-LQQ 1889
++ EK+ +T Q ILE K+K+L LV K EE+T + +LQ ++
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS------EEMTLQINELQKEIEI 730
Query: 1890 MDGRNKPTELLEENTEE-KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
+ K LE+ +E + K+ L++ + M+ + NDL+ K A E E L E
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQ----MKEKENDLQEKFAQLEAENSILKDEKKT 786
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+ L++ Q+E I + ++ + +++ ++ ++ N LKQ + N ++ ++
Sbjct: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
K QE+ QEE LLK + +D + Y+ L A E
Sbjct: 847 RNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 2069 EM------TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL-------QTQLAQK 2115
E+ V+ + +E + + LE E D +ME + +L+Q+
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 2116 TTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
+ +S+ +LK++ N E + K EK
Sbjct: 959 LSDLSE-QLKQKHGEISFLNEEVKSLKQEK 987
Score = 111 bits (277), Expect = 9e-24
Identities = 151/689 (21%), Positives = 314/689 (45%), Gaps = 89/689 (12%)
Query: 1467 LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
LE+ E K +I L EL++ + + + K+ + T+L + +
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
+D ++ +E+ ++ L+ QQ ++ E ++ H + + +A+++
Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQ--LQASETLRNSTHSSTAAD-----LLQAKQQ 269
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
ILT + Q+ LE +K+ E + + +E++K E E +K E
Sbjct: 270 ILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----------MEQDKKVEN 318
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS----Q 1702
S EE +E+ E+ + ELNTK+ E E++ L++KL + + Q
Sbjct: 319 ----------SNKEEIQEK-----ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQ 363
Query: 1703 SETLIVPRSAKNVA---AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE---KLLQRVG 1756
+ + + KN+ ++Q+E S +++ + +RN + + ++QR+
Sbjct: 364 EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME 423
Query: 1757 QEKEETVSS-HFEMRCQYQERLIKLEHAEAKQHEDQ--SMIGHLQEELEEKNKKYSLIVA 1813
QE + + E+ Y +++++++ +QH Q M + E+E + YS I
Sbjct: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
Query: 1814 QHVEKEGGKNNIQAKQ-NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV 1872
E + N+ + N++ + QK ++EL ILE+K L RQ E
Sbjct: 484 N--EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL-ILEEKC-----ALQRQLEDL-- 533
Query: 1873 EMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
+EEL+ E++Q +Q + L E + S ++ +++S E++ +LE K
Sbjct: 534 -VEELSFSREQIQRARQTIAEQESK--LNEAHKSLSTVEDLKAEIVSASESR-KELELKH 589
Query: 1933 AGAEREKQKLGKEIVRLQKD--LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
AE K+ E++ +K+ L + + + ELE L+ + EE++ + +EDLE++H
Sbjct: 590 E-AEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH 648
Query: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
+++L + L + K+ I+ Q ++ +E+ Q E + L+ K +
Sbjct: 649 RINIEKL-----------KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK--LEQEENPGNDNVTIMEL 2108
++ + + +++++ EEMT ++ +LQ ++E L+++ ++K LEQE V ++L
Sbjct: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE-------VQELQL 750
Query: 2109 QTQLAQKTTLISDSKLKEQEFREQIHNLE 2137
+T+L +K K KE + +E+ LE
Sbjct: 751 KTELLEK-----QMKEKENDLQEKFAQLE 774
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 230 bits (586), Expect = 1e-59
Identities = 458/2387 (19%), Positives = 993/2387 (41%), Gaps = 348/2387 (14%)
Query: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66
QK+ + QQLQ + ++ +S+ ++++ T Q + D Q +
Sbjct: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295
Query: 67 LRVPSVES---LFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123
+++ ++ ++ + + S+ +E + + E LN ++ + + D +
Sbjct: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTT 354
Query: 124 AEDLVGNSDSLNKEQLIQR---LRRMERSLSSYRGKYSE--------LVTAYQMLQREKK 172
A+ L+G +EQ++Q+ ++ M+ L++ + K + + T ++ +R K
Sbjct: 355 ADKLLGEL----QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 173 KLQ---GILSQSQDKSLRRIAELREEL-----QMDQQAKKHLQEEFDASLEE-----KDQ 219
Q I+ + + ++ R++ +LR EL Q Q K+ L + A +EE K +
Sbjct: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 220 YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
+ L++ ++ + MNV + + +L+ KE+ E G + E +
Sbjct: 471 MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS--QKEKLKEELGLILEEKCALQR 528
Query: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
LE L + + ++R ++TI + + +++ E + E K+L +
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVI--------AETKRQMHETLEMKEEEIAQLRSRI 391
+ ++ + K +E LE++K V+ AE +R + L EEE+++L+ +
Sbjct: 589 HEA----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644
Query: 392 K-QMTTQGEELRE-------------QKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
+ + E+L++ Q E S++ + EK + K + ++
Sbjct: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLK 703
Query: 438 DEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQ---KLHEKELAR 491
D Q + SEE + LQ+E+ ++QE + K + E+++ +LQ +L EK++
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE--KGTLEQEVQELQLKTELLEKQMKE 761
Query: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-LEELELQKKAILTE 550
KE +L +K E E + +K+ + LKI Q+E L L+ ++ + K + E
Sbjct: 762 KENDLQEKFAQLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
E ++ L +E E + + ++L +EK K+ V+ + + ++ +
Sbjct: 820 KEIEI--LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY-----ACLL 872
Query: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
K K +LE K++Q+ + KL+ L ++ ++++ + K ++ D++ F A E
Sbjct: 873 KVKDDLEDSKNKQELEYKSKLKALNEELH--LQRINPTTVKMKSSVF-DEDKTFVAETLE 929
Query: 671 MNE-------KTLEKLDVKQTELESLS---SELSEVLKARHK----LEEELSVLKDQTDK 716
M E + +EKL+V + E LS S+LSE LK +H L EE+ LK + ++
Sbjct: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989
Query: 717 MK---QELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRTEKALKDQINQLELLLKERDKHL 772
+ +ELE ++ + + Q D+ + + + T + + ++++ E K +
Sbjct: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049
Query: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQLAQLQQKLLD 830
E + EN+ + + +L + S T E + + +LQ++L
Sbjct: 1050 VEDKVSFENMTVGEESKQEQL--------ILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
Query: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS----------EMEQK 880
L++E+ L Q +EAQ+ + H QV++ M+ EK + E+K
Sbjct: 1102 LKSEQNDLRLQ---MEAQRICLSLVYSTHVDQVREYMEN-EKDKALCSLKEELIFAQEEK 1157
Query: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
+K L ++++ +L+ + ++T +I ++++ +E Q L + +
Sbjct: 1158 IKELQKIHQLELQ--TMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCS------V 1209
Query: 941 LNEEYETKFK-----------------NQEKKMEKVKQKAKEMQE---TLKKKLLDQEAK 980
L E Y K N++ +++ + + ++ QE TL K+ ++ K
Sbjct: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
Query: 981 LKKELENTALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLE---TNQKEQIESLT 1033
L + Q+ + +F + L + I ++ LE N K ++ SL
Sbjct: 1270 LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ 1329
Query: 1034 EVHRRELNDVISIWE---KKLNQQAEELQEIHEIQ---LQEKEQEVAEL----------- 1076
++ + +L + + E L QQ +E ++ +E + LQ++ Q V+E
Sbjct: 1330 DLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSV 1389
Query: 1077 ------KQKILLFG-CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Q+ + G C K+ ++ I + E GVK++T + +L E+ Q+
Sbjct: 1390 VITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIV 1449
Query: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
+ A ++ E+ KENT +Q + ++++ +E+ KL FQ+ +
Sbjct: 1450 SMSIAFAQQTELSRISGGKENTASSKQ---AHAVCQQEQHYFNEM--KLSQDQIGFQTFE 1504
Query: 1190 SSHEKSNKSLEDKSLEFKKLSEE------------------LAIQLDICCKKTEALLEAK 1231
+ K + + S E + +E L I ++ K ++
Sbjct: 1505 TVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564
Query: 1232 TNELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL---TEEQN 1286
++ I++SS + +L+ R V++ + T +A +RQ+ E+Q
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE 1624
Query: 1287 TLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKESCI-- 1341
L ++ QL ++ + D E+LV+E+E + + E Q A ++ C
Sbjct: 1625 QLQEEIKRLNRQLAQRSS------IDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
Query: 1342 ------TQLKKELSENINAVTLMKEELKEKKVEI--SSLSKQ------------------ 1375
TQ E + T ++EL K ++ LS +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 1376 -----------------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
+ D + + Q+S SL + A +S++ EE + D+ S
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE-SIPS 1797
Query: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
+ + + I+ +V + + S+ ++ T+ +EL + + + + A EK
Sbjct: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEK- 1856
Query: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHIT 1535
L E + + + + + K + + +++ LK Q R+ E
Sbjct: 1857 -----LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE 1911
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE---KDNRVKEAE-------E 1585
Q +E+ V+ Y +K + +++ +K L +E NR++E E E
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE 1645
+ L Q +MKAE +++L + ++ E++ +++ + ++ L+ E
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
Query: 1646 QKIAAI------KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
++++ K L + ++ + +K E L+ + +RE E + +++++ +E
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
Query: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK 1759
+ +VPR T + E + +KT +K S L L KE+L + + +
Sbjct: 2092 ---QQLKVVPRFQPISEHQTREVEQLANHLKEKT--DKCSEL---LLSKEQLQRDIQERN 2143
Query: 1760 EETVSSHFEMRCQYQERLIK---LEHAEAKQH-------EDQSMIGHLQEELEEKNKKYS 1809
EE F +R Q L+ + E ++H + S+ LQ E + ++K
Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK 2203
Query: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
I + E Q ++ LEN ++VQ+ + E+ + +++EL+ ++ ++
Sbjct: 2204 EITNLEEQLE------QFREELENKNEEVQQLHMQLEIQKKESTTRLQELE----QENKL 2253
Query: 1870 HRVEMEELTSKYEKLQALQQMDGR---NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
+ +ME+L ++ A+ D K ++++E E + + KL ++ +
Sbjct: 2254 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2313
Query: 1927 DLEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED 1985
+ K+ + E + L +I L D +++ ++E+E L E EK++QE +
Sbjct: 2314 N---KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL-----NEVIEKLQQELAN 2365
Query: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-----ELLESHQEETNQ 2040
+ K + L E ++ + +L++ I E + Q+VE +++ +ETN
Sbjct: 2366 IGQKTSMNAHSLSEEADS----LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
Query: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--------KKYQQKL 2092
+ ++ ++ LKR + E+I E + + L EL+ K + +
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT 2481
Query: 2093 EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
+ N +I+ L+T+L Q + +S L+ + +QI +++++
Sbjct: 2482 YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
Score = 223 bits (568), Expect = 2e-57
Identities = 451/2272 (19%), Positives = 930/2272 (40%), Gaps = 397/2272 (17%)
Query: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162
N+L L+ S S ++S++E++ + L KE I+ LR+ E+ + + EL
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE--IEILRQEEKEKGTLEQEVQELQL 750
Query: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-MDQQAKKHL---QEE---FDASLE 215
++L+++ K+ + L + + + L++E + ++ K H QEE F S++
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 216 EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275
K + SV + ++ +L + N D+ + QL + E K+ N S E
Sbjct: 811 SKSKD-SVWEKEIEILIEE------NEDLKQQCIQLNEEIE---KQRNTFSFAE------ 854
Query: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL-LTSEKEALQEQLDERLQELEKIK 334
K E Q ++ + L + K+ ++ K + L S+ +AL E+L L++I
Sbjct: 855 ---KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-----HLQRIN 906
Query: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
+ K+ + + D + E LE G V+ + ++ E LE+ + E +L R+ +
Sbjct: 907 PTTVKMKSSVFDE--DKTFVAETLEM--GEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
Query: 395 TTQ-----------GEELREQKEKSERAAFE--ELEKALS--TAQKTEEARRKLKAEMDE 439
+ Q EE++ K++ E+ + ELE ++ A+ + ++ + +D
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
Query: 440 QIKTIEKTSE------------------EERISLQQ----ELSRVKQEVVDVMKKSSEEQ 477
+ + +E E+++S + E S+ +Q ++D + ++E
Sbjct: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082
Query: 478 IAKLQKLHEKELARKEQELTKKLQT----------------------REREFQEQMKVAL 515
+ + E + +KE + K Q + RE+ E K
Sbjct: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
Query: 516 EKSQSEYLKISQEKEQQESLALEELELQ---------------------KKAILTESENK 554
S E L +QE++ +E + +LELQ +KA+ E
Sbjct: 1143 LCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202
Query: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
L+ L Y T L+ E + E + +N ++ + + E + E+ E T
Sbjct: 1203 LQTLCSVLGEYYTPALKCEVNAE----DKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
Query: 615 ELESLKHQQDAL----------WTEKLQVLKQQYQTE---MEKLREKCEQEKETLLKDKE 661
L + + + L W ++ +K ++ E E+ + T L+D +
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR--------HKLEEELSVLKDQ 713
+ ++ + + + KL+ + ELESL S L + LK H L++ L + +
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 714 TDKMKQELEAKM-DEQKNHHQQQVDSIIKEH-EVSIQRT-EKALKDQINQLELLLKERDK 770
T +++ + E S +K++ + +I+ + E +K++ N ++LL K+ +
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE 1438
Query: 771 HLKEH--------------------------------QAHVENLEADIKRSEGELQQASA 798
L+E QAH + +E +L Q
Sbjct: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQI 1498
Query: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLL----------------------DLETERI 836
F++ E+ K ++L + +++L ++
Sbjct: 1499 GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 837 LLTKQVA--EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
+ +Q E+ D +L ++ Q++D+ Q+L +Q E +Q + L Q + ++E
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 895 GNKEQEQTKQIL------------VEKENMILQMREGQKKEIEILTQKLSAKEDSI--HI 940
++QEQ ++ + ++ EN++ + +E+E L Q A + + +
Sbjct: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
Query: 941 LNEEYETKFKNQEK-KMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKE 996
N +T+ N+ + ++E+ K KE+ E + ++L E ++ N L++ +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL--NDVISIWEKKLNQQ 1054
+ A + E + GI D S+ +++ S E + + + ++ +
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
Query: 1055 AEELQEIHEIQLQEK-EQEVAELKQKIL---LFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
+ ++I + K +E EL Q+++ G E + N+E+ + + + +
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL--MLNISSRLQAAVEK 1856
Query: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
L E + + S+ + +T+L + + + +SLK L+E+L E+ R
Sbjct: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL-------HEESRA 1909
Query: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
+L +L + + +++K+ +L +EL +C LEA
Sbjct: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCASNRLQELEA 1964
Query: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
+ ++ + +LSR KEA+ +E QL Q TE+ +
Sbjct: 1965 EQQQI-----QEERELLSR----------QKEAM---KAEAGPVEQQLLQETEKLMKEKL 2006
Query: 1291 SFQ-QATHQLEEKENQIKSMKADIESLVTEKEALQKEGG------NQQQAASEKESCITQ 1343
Q QA ++ + Q+K+++ D+E V+ L++E QQ A EK+ + +
Sbjct: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ--LEK 2064
Query: 1344 LKKELSE---------NINAVTLMKEELKEKKV-EISSLSKQLTDLNVQLQNSISLSEKE 1393
++K L E ++ + K E + K V +S+ T QL N L EK
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN--HLKEKT 2122
Query: 1394 AAISSL---RKQYDEEKCELLDQVQDLSFKVDTLSKEKI---SALEQVDDWSNKFSEWKK 1447
S L ++Q + E ++++ L F+V L + + ++V+D F +
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVED-RKHFGAVEA 2181
Query: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
K + L++QL+ + K+++I L+E+L+Q + E+E+
Sbjct: 2182 KPE----------LSLEVQLQAERDAIDRKEKEITNLEEQLEQ-------FREELENKNE 2224
Query: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN--------------- 1552
++++ LE + K T R+ ELE ++E L +K +
Sbjct: 2225 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2284
Query: 1553 ---QQKDIEHKEL---VQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELE--- 1602
Q+K++E +L V KLQ Q+L DN+V +E E I LE Q+ + ++ E
Sbjct: 2285 QIIQEKEVEIDQLNEQVTKLQ--QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
Query: 1603 -TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE----LKRKAEQKIAAIKKQLLS 1657
+++E+E +N ++ ++EL + + S +A L+E LK + + IA +K L
Sbjct: 2343 RNREEEIEQLNEVIEKLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIA--EKLALE 2399
Query: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA- 1716
Q E + ++ L E N K+ + +E+ L+ + +SVE QS +P ++ NVA
Sbjct: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS----IPENSVNVAI 2455
Query: 1717 -------------------------AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE-K 1750
Y + E + +G + E ++ L+ ++ K+ +
Sbjct: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI-INLETRLLQLESTVSAKDLE 2514
Query: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
L Q Q K+ FE Q++++ L+ ++ +++ +Q E ++ K+
Sbjct: 2515 LTQCYKQIKDMQEQGQFETE-MLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQ 2572
Query: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Q + E + NIQ L D++ + L LE ++ E+ + L+ +KE
Sbjct: 2573 -DNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQV 2629
Query: 1871 RVEMEELTSKYEKLQALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929
+ + + K +KL LQ+ ++G K ++ +EK +S L + E H++ E
Sbjct: 2630 EIAEKNVLEKEKKLLELQKLLEGNEK-----KQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
Query: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLEL 1988
+G E + L E V + +L + K + + E+L KE + +K + D
Sbjct: 2685 ---SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2741
Query: 1989 KHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
+ L L +E T++ + ++ + IK + + A + + L S +T Q+L K
Sbjct: 2742 EAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2801
Query: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
A +L+ + EE+T + ++E++Q+ + ++ E+
Sbjct: 2802 AGIQINLQS---------ECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2844
Score = 214 bits (544), Expect = 1e-54
Identities = 393/1898 (20%), Positives = 805/1898 (42%), Gaps = 290/1898 (15%)
Query: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL--------STAQKTEE 428
LEM E E+A + I+++ + EE+R +E E A+ ++
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 429 ARRKLKAEMDEQIKT-IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI--AKLQKLH 485
ARR E DE ++ +E T + +++ +Q + + + + + S+ + AK Q L
Sbjct: 217 ARR----EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272
Query: 486 EKELARKEQELTKKLQTREREF-------QEQMKVALEKSQSEYLKISQEKEQQESLALE 538
++ ++ L + Q ++ +F QE++KV E Q + ++ S ++E QE +
Sbjct: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETII 331
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEA 596
E EL K I E E K +L+ + T + EL+ + + QE KN +L + E
Sbjct: 332 E-ELNTKII--EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER 388
Query: 597 EKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKET 655
+ ++ K++ VE EL+ H+ T+ +Q ++Q+ Q ++E+LR E E +
Sbjct: 389 QSSEEIKQLMGTVE----ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS------ELSEVLKARHKLEEELSV 709
+++ K+ + + H+ +M E + L S S+ ++ + A ++L +L
Sbjct: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
Query: 710 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Q +K+K+EL + E+K Q+Q++ +++E S ++ ++A + I + E L E
Sbjct: 505 TNSQKEKLKEELGLIL-EEKCALQRQLEDLVEELSFSREQIQRA-RQTIAEQESKLNEAH 562
Query: 770 KHLKEHQAHVENLEADI-----------KRSEGELQQASAKLDVFQSYQSATHEQ-TKAY 817
K L + VE+L+A+I + E E+ KL++ + ++A ++ ++
Sbjct: 563 KSL----STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ 618
Query: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL--------MQQ 869
E +L +L+ +LL E + K+ E+E H+I ++ L QQ
Sbjct: 619 EAELERLRTQLLFSHEEELSKLKEDLEIE------------HRINIEKLKDNLGIHYKQQ 666
Query: 870 LEKQNSEMEQKVKS--------LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK 921
++ +EM QK+++ +T+ + LE + Q + + E M LQ+ E Q
Sbjct: 667 IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ- 725
Query: 922 KEIEILTQKLSAK---EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978
KEIEIL Q+ K E + L + E K ++K +++K +++ + +L E
Sbjct: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE--AENSILKDE 783
Query: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ--KEQIESLTEVH 1036
K +++ +SQ+E+ ++ +S + +E N+ K+Q L E
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE--I 1094
++ N S EK +ELQE + L+ K+ ++ L + + + +N+E +
Sbjct: 844 EKQRN-TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ-DETKLKAHLEKLEVDLNKSLKENTFL 1153
+ VK +++ + + ++ + + + D T+L +EKLEV + L+ + L
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTEL---MEKLEVTKREKLELSQRL 959
Query: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
+ L+E+ K+K E++ +EE +SLK EK SL + LE ++
Sbjct: 960 SD-------LSEQLKQKHGEIS----FLNEEVKSLK--QEKEQVSLRCRELEI-IINHNR 1005
Query: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK--VKEALLIKTCTV 1271
A + C + +LL+ ++ ++S +S+++ +K V++ + + TV
Sbjct: 1006 AENVQSCDTQVSSLLDG----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 1272 SELEAQLRQL-------TEEQNTLNISFQQATHQLEEKENQIKSMKADIE---------- 1314
E E++ QL ++++L + +L+++ N +KS + D+
Sbjct: 1062 GE-ESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICL 1120
Query: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE----KKVEIS 1370
SLV Q ++ +EK+ + LK+EL + +E++KE ++E+
Sbjct: 1121 SLVYSTHVDQV----REYMENEKDKALCSLKEEL------IFAQEEKIKELQKIHQLELQ 1170
Query: 1371 SLSKQLT-DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
++ Q T D L + + + + A+S + + C +L + + K + +++K
Sbjct: 1171 TMKTQETGDEGKPLH--LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKE 1228
Query: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
++ + + + ++ V++ Q + + E+ ++ +L+ L
Sbjct: 1229 NSGDYISE----------NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLS 1278
Query: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNL---ETELKSQTARIMELEDHITQKTIEIESLNE 1546
+ + G+ + D K+E E NL ETE S +++ LED ++ SL
Sbjct: 1279 K-------IWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL-- 1328
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+D+E +L +++Q + L ++KE E+ + +AE+ +K
Sbjct: 1329 --------QDLEKTKLEEQVQELESLISSLQQQLKETEQ----------NYEAEIHCLQK 1370
Query: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
L+ V+ S + L +S ++ + +KK + +E E
Sbjct: 1371 RLQAVSES---------TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
Query: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
K + + L + QE+ LEE++ V S S ++ E +
Sbjct: 1422 VKEETNIVKLLEKQYQEQ------LEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSK 1475
Query: 1727 QG---CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Q C Q+ Q E + ++G + ETV F+ K
Sbjct: 1476 QAHAVCQQE---------QHYFNEMKLSQDQIGFQTFETVDVKFKEE-------FKPLSK 1519
Query: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
E +H + ++ + ++K L +++ + + ++ +++ D++ +
Sbjct: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR-----QSIHDEISVSSM 1574
Query: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903
+ + E++++++ LVRQ + H+ E L + + Q+ D E+ N
Sbjct: 1575 DASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634
Query: 1904 TEEKSKSHLVQPKLLSNME-AQHNDLE----FKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
+ +S + L+S E +LE LAG E+ +L + Q
Sbjct: 1635 RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNG-----N 1689
Query: 1959 EHQQELE---ILKKEYDQERE----EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ- 2010
E+Q E+E +KE D++ E E + E+ L+ +N LK L+ T A +E
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749
Query: 2011 -ELEMTIKETINKAQ---------EVEAELL----ESHQEETNQLLKKIAEKD---DDLK 2053
+ I + +K+Q E EA + E H T++ + + D +D+
Sbjct: 1750 GRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809
Query: 2054 RTAKRYEE----------------ILDAREEEMTAKVRD-LQTQLEELQKKYQQKLEQEE 2096
+K EE +D EE+ + LQ +E+L + + Q E
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE 1869
Query: 2097 NPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134
+ VT EL + ++ ++S ++E RE++H
Sbjct: 1870 HA---KVTQTELMRESFRQKQEATESLKCQEELRERLH 1904
Score = 209 bits (532), Expect = 2e-53
Identities = 487/2248 (21%), Positives = 912/2248 (40%), Gaps = 417/2248 (18%)
Query: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
S +K ++++ E S+SS ++ Q+ ++ ++ Q L R A +
Sbjct: 1554 SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613
Query: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252
R+ ++ ++ ++ LQEE + Q S+ +L+ +R R ++ LK L L
Sbjct: 1614 RQ-MERQREDQEQLQEEIKRLNRQLAQRSSI--DNENLVSERERVLLEELEALKQL-SLA 1669
Query: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312
+ ++ + N + + E+ V+ +Q K +E L R E + +L
Sbjct: 1670 GREKLCCELRNSSTQTQNGNENQGEVE-----EQTFKEKE--LDRKPEDVPPE-----IL 1717
Query: 313 TSEKEALQEQLDERLQEL-EKIKDLHMAEKT---------KLITQLRDAKNLIEQLEQDK 362
++E+ ALQ+ + L+ L E +K E+T ++ + + +LI + E +
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAE- 1776
Query: 363 GMVIAETKRQMHET-LEMKEEEIAQL------RSRIKQMTTQGEELREQKEKSERAAFEE 415
A K +HE + +E I R+ I + EE E ++ R+ F
Sbjct: 1777 ----ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832
Query: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE------ERISLQQELSRVKQEVVDV 469
E + +L+A +++ ++ I +TS + + L +E R KQE +
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892
Query: 470 MKKSSEEQIAKLQKLHEKELARKEQ--ELTK----------KLQTREREFQEQMKVALEK 517
+K E + ++LHE+ AR++ EL+K + ER+ QE+ + +++
Sbjct: 1893 LKCQEELR----ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI-IDR 1947
Query: 518 SQSEYLKIS---QEKEQQESLALEELEL---QKKAILTESENKLRDLQQEAETYRTRILE 571
+ E L S QE E ++ EE EL QK+A+ E+ + L QE E LE
Sbjct: 1948 LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007
Query: 572 LESSLEKSLQENKNQSKDLAV----------HLEAEKN-------KHNKEITVMVEKHKT 614
++ EK + + Q K L + LE EKN + N+ + +EK +
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2067
Query: 615 ELESL----KHQQDALWTEKLQVLKQQ------------YQT-EMEKL----REKCEQEK 653
L+ +H++D ++ +++Q L+QQ +QT E+E+L +EK ++
Sbjct: 2068 FLDEQAIDREHERD-VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE-------------------------- 687
E LL +++ Q I+E NE+ +EKL+ + ELE
Sbjct: 2127 ELLLSKEQL--QRDIQERNEE-IEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKP 2183
Query: 688 --SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
SL +L A + E+E++ L++Q ++ ++ELE K +E + H Q ++ KE
Sbjct: 2184 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKKESTT 2242
Query: 746 SIQRTE---KALKDQINQLELLLKERDKHLKEHQAHVENLEADI-KRSEGELQQASAKLD 801
+Q E K KD + +L L +KE D + Q + A I + E E+ Q + ++
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
Query: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Q T + K EE+ + + DLET+ L +++ E K++ E++
Sbjct: 2303 KLQQQLKITTDN-KVIEEK----NELIRDLETQIECL---MSDQECVKRNREEEIEQLNE 2354
Query: 862 QVQDLMQQLEKQNSEMEQKVKSLTQ-----------------VYESKLEDGNKEQEQTKQ 904
++ L Q+L + SL++ E ++E N+E K
Sbjct: 2355 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2414
Query: 905 ILVE---KENMILQMREGQKKEIEILTQKLSAKEDSI-----HILNEEYETKFKNQEKKM 956
+L E K N + Q K+E E + + S E+S+ H+ ++ E + E +
Sbjct: 2415 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2474
Query: 957 EKVKQKA--KEMQETLKKKLLDQEAKLKKELENTA----LELSQ---------KEKQFNA 1001
+ ++ + K +E K +++ E +L +LE+T LEL+Q ++ QF
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLL-QLESTVSAKDLELTQCYKQIKDMQEQGQFET 2533
Query: 1002 KMLE------------------MAQANSAGISDAVSRLETNQ-------KEQIESLTEVH 1036
+ML+ ++Q + + + NQ + I++L ++
Sbjct: 2534 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2593
Query: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ-EVAE----------LKQKILLFGC 1085
EL IS ++++ ++ E+H + EKEQ E+AE L+ + LL G
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN 2653
Query: 1086 EKEEMNKEITWLKE--EGVKQDTTLNELQEQ------LKQKSAHVNSLAQDETKLKAHLE 1137
EK++ KE + E +K T L E+ L+ A + + K E
Sbjct: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2713
Query: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
KL+ +L T LQ+ L +++ E K K+S L + +T +E S K
Sbjct: 2714 KLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE----------SKK 2763
Query: 1198 SLEDKSLEFKKLSEELAIQLDICCK-----KTEALLEAKTNELINISSS-KTNAILSRIS 1251
+ + L K LS+ +A Q D K +T +L IN+ S + + IS
Sbjct: 2764 ACMFEPLPIK-LSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS 2822
Query: 1252 HCQHRTTKVKEA-----LLIKTCTVSELEAQLRQ-------LTEEQNTLNISFQQATHQL 1299
+ K++E L +++ +SE E R+ L EE TL Q L
Sbjct: 2823 QFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC----L 2878
Query: 1300 EEKENQIKSMKADIESLVTEKEALQKEGGNQQQA----------------ASEKESCITQ 1343
KE A ++ T + G + Q E ES
Sbjct: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS 2938
Query: 1344 LKKELSENINAVTLMKEELKEKKVEISSLSKQL----TDLNVQLQNSISLSEKEA---AI 1396
K++ + AV + +++ SL++ D ++Q + L E++A I
Sbjct: 2939 FPKKIKGLLRAV-------HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI 2991
Query: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSK---EKISALEQV------------------ 1435
SSL+ + + + +V D S ++ S E + AL+QV
Sbjct: 2992 SSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
Query: 1436 ---DDWSNKFSEWKKKAQSRFTQHQNTVKELQ------IQLELKSKEAYEKDEQINLLKE 1486
D + +++ Q + ++Q ++ LQ + E+++ A +I L +E
Sbjct: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKRE 3111
Query: 1487 -----------ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
E + Q K+ L EM+ + S M+ + + L+ +L S+ + EL+ +
Sbjct: 3112 QESEKPSQELLEYNIQQKQSQML--EMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3169
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
Q +E+E+ + + ++ + E+ K L + + K++ E LE +
Sbjct: 3170 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3229
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
+ E K+ELE + S++S+++ L LE + KQL
Sbjct: 3230 KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ--------------------KQL 3269
Query: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
L++ ++K E + ++ LSE Q R E+ +L E K S TL + +
Sbjct: 3270 LNESQQKIESQRMLYDAQLSE----EQGRNLELQVLLESEKVRIREMSSTL---DREREL 3322
Query: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
A + + Q E+ + LQ+ L EK + + E E+ + R Q ++
Sbjct: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3382
Query: 1776 ------RLIKLE-----HAEAKQHEDQSMIGHLQEELEEKNKK-YSLIV----AQHVEKE 1819
+ ++ E + K HE QS + LQ +LEEK ++ Y L + Q + +E
Sbjct: 3383 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3442
Query: 1820 GGKNNIQAKQNLE-------NVFDDVQKTLQEKELTCQILEQKI--KELDSCLVRQKEV- 1869
K ++ ++ E N+ + +L +L+QKI + +S + E+
Sbjct: 3443 FQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMN 3502
Query: 1870 -------HRVEM--EELTSKYEKLQALQQMDGRNKPTELLEEN----TEEKSKSHLVQPK 1916
H +EM ++L KLQ L Q E ++ +E ++Q +
Sbjct: 3503 GGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562
Query: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976
L+ + + L ++L ++ L + L +E ++ K E
Sbjct: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK-----LE 3617
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQ-LAQKEQELEMTIKETINKA-QEVEAELLESH 2034
E+I+ ++ + NS+ L N + + E+E+ K T+ K+ + EAE+ +
Sbjct: 3618 EQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3677
Query: 2035 QEETNQLLKKIAEKDDD---LKRTAKRY 2059
E N L + D + LKR +Y
Sbjct: 3678 AELRNDSLLQTLSPDSEHVTLKRIYGKY 3705
Score = 209 bits (531), Expect = 3e-53
Identities = 425/2210 (19%), Positives = 918/2210 (41%), Gaps = 334/2210 (15%)
Query: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQM-LQREKKKLQGI 177
D+D + + + L K +L ++++ +E +SS + + E Y+ + +K+LQ +
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV 1375
Query: 178 LSQSQDKSLR--RIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL 235
+ SL + + Q +++ D ++E ++ +T + L ++
Sbjct: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435
Query: 236 RNGPMNVDVLKPLPQLE----------------------PQAEVFTKEENPESDGEPVVE 273
+ +V K + + QA ++E + + +
Sbjct: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ 1495
Query: 274 DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKI 333
D +T ET+ + K + K + + H ++ L S+ + E D L E
Sbjct: 1496 DQIGFQTFETVDVKFKEE---FKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE-- 1550
Query: 334 KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQ 393
++ +KT ++ Q + + + + RQ L + EE++ +R ++
Sbjct: 1551 -EMFSKDKTFIVRQ---------SIHDEISVSSMDASRQ----LMLNEEQLEDMR---QE 1593
Query: 394 MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ--IKTIEKTSEEE 451
+ Q +E ++ E +A ++E+ ++ +E ++L ++ ++ I SE E
Sbjct: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
Query: 452 RISLQQ-----ELSRVKQEVV--DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE 504
R+ L++ +LS +E + ++ S++ Q + +E KE+EL +K +
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVP 1713
Query: 505 REFQEQMKVALEKSQSEYLKISQE-----------------------KEQQESLAL---E 538
E + AL+K+ + LKI E + Q S +L
Sbjct: 1714 PEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRS 1773
Query: 539 ELELQKKAILTESENKLRD----------LQQEAETYRTRILELESSLEKSL-------Q 581
E E K+ + E ++ D + + +++ E + L + L
Sbjct: 1774 EAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGT 1833
Query: 582 ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641
E ++++L +++ + +++ + + ++LE K Q L E + ++Q TE
Sbjct: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFR--QKQEATE 1891
Query: 642 ----MEKLREKCEQE---KETL---LKDKEIIFQAHIEE-------MNEKTLEKLDVKQT 684
E+LRE+ +E +E L L E + + +E + EKT + +D +
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKT-DIIDRLEQ 1950
Query: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
EL S+ L E+ + +++EE +L Q + MK E +++Q +++ E +
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA-GPVEQQLLQETEKLMKEKLEVQ 2009
Query: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
++ L+ Q+ LE+ ++E+ E + D+++ L++ K+ F
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 805 SYQSATHEQTK-AYEEQLAQLQQKLLDLETERILLTKQVAEVEA------QKKDVCTELD 857
Q+ E + +++++ +L+Q+L + + + Q EVE +K D C+EL
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 858 AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR 917
K Q+Q +Q+ ++ ++E +V+ L Q + K +++ VE
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA-------- 2181
Query: 918 EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
K E+ + Q L A+ D+I + E + N E+++E+ +++ + E +++ +
Sbjct: 2182 ---KPELSLEVQ-LQAERDAI----DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2233
Query: 978 EAKLKKELENTALELSQKEKQFNAKM--LEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
E + KKE EL Q+ K F M L +A S +S + + QI EV
Sbjct: 2234 EIQ-KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2292
Query: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT 1095
+LN+ ++ KL QQ + + I+ EK + + +L+ +I ++E + +
Sbjct: 2293 EIDQLNEQVT----KLQQQLKITTDNKVIE--EKNELIRDLETQIECLMSDQECVKRN-- 2344
Query: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHV--------NSLAQDETKLKAHLEKLEVDLNKSL 1147
+EE ++Q LNE+ E+L+Q+ A++ +SL+++ LK L+ + +
Sbjct: 2345 --REEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
++ E++ +K + +E K+++LT +L + E +S++ S+
Sbjct: 2400 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2459
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
K EL + L TE L++ N+ S + N S I+ ++ LL
Sbjct: 2460 KDKPELEVVL------TEDALKSLENQTY-FKSFEENGKGSIIN--------LETRLLQL 2504
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT-------EK 1320
TVS + +L Q ++ + Q T L++K I +++ +E V +
Sbjct: 2505 ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK---IVNLQKIVEEKVAAALVSQIQL 2561
Query: 1321 EALQKEGG---NQQQAASEKESC----ITQLKK-ELSENINAVTLMKEELKEKKVEI-SS 1371
EA+Q+ + Q +SE E + QL++ EL +I+A+TL EL+ + VE+ +S
Sbjct: 2562 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621
Query: 1372 LSKQLTDLNVQLQNSISLSEKEAAISSL-----RKQYDEEK-------------CELLDQ 1413
L + + + +N + +K + L +KQ ++EK EL
Sbjct: 2622 LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2681
Query: 1414 VQDLSF--KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
++ F +++ L E ++ ++ + K +K Q + + LQ L
Sbjct: 2682 NEESGFFNELEALRAESVATKAELASYKEK----AEKLQEELLVKETNMTSLQKDLSQVR 2737
Query: 1472 KEAYEKDEQINLLK--EELDQQNKRFDCLKGEM--EDDKSKMEKKESNLETELKSQTARI 1527
E E++++L+ +E + Q + C+ + + KS + + L+ +QT +I
Sbjct: 2738 DHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQI 2797
Query: 1528 MELEDHIT---QKTIEIESLNEVLKNYNQQ----KDIEHKELVQ-KLQHFQE---LGEEK 1576
+ I Q E + E++ + ++ +++ E++ + +H E L E
Sbjct: 2798 LVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEH-------------------------- 1610
V+ +E+ TL+ + ++++ + EL H
Sbjct: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917
Query: 1611 ---VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK----------QLLS 1657
+++ + + EE ++ D + L + + Q ++ + Q +S
Sbjct: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977
Query: 1658 QMEEKEEQYKKGTESHLSELNTKLQ-EREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
+ +E + T S L +L TK+Q +RE EV+ + +S + E L+
Sbjct: 2978 EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA-------- 3029
Query: 1717 AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE-KEETVSSHFEMRC-QYQ 1774
+Q + + + + +++ L T+ LL + Q +E+ V M C Q
Sbjct: 3030 --LQQVFLEERSVLLAAFRTELTAL--GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA 3085
Query: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK-QNLEN 1833
+R L +A + L+ E E + L+ +K+ +Q + ++++
Sbjct: 3086 DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKD 3145
Query: 1834 VFDDVQKTLQEKELTCQILEQKIK----ELDSCL------VRQKEVHRVEMEELTSKYEK 1883
++Q+ L +++ L+ ++ EL++ L +++ E R+E+++ T +
Sbjct: 3146 RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL 3205
Query: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
L + + K EL +EK+K + + +E DL+F L E +KQ+
Sbjct: 3206 LNDTLASE-QKKSRELQWALEKEKAKLGRSEERDKEELE----DLKFSL---ESQKQR-N 3256
Query: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK--------IKQEQEDLELKHNSTLK 1995
++ L + + L E QQ++E + YD + E+ + E E + ++ S+
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 1996 QLMREFNTQLAQKEQE--------LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047
RE + QL + E +KE + +E + ++E E L +
Sbjct: 3317 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
Query: 2048 KDDDLKRTAKRYEEILDAREEEMTA---KVRDLQTQLEELQKKYQQKLEQ 2094
+ +++ + + + L +E T K+ +LQ+++E+LQ++ ++K +Q
Sbjct: 3377 RQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
Score = 206 bits (525), Expect = 2e-52
Identities = 488/2438 (20%), Positives = 982/2438 (40%), Gaps = 427/2438 (17%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
K+ K+++S ++L+ + +A + S T++ S G S +SF
Sbjct: 984 KQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFG 1043
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD--M 120
++ ++ V S + E S +E L+ + L + +SS + P + +
Sbjct: 1044 EESKIMVEDKVSFENMTVGEE----SKQEQLIL----DHLPSVTKESSLRATQPSENDKL 1095
Query: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKK----KLQG 176
E L + L + QR+ LS + + V Y +++K K +
Sbjct: 1096 QKELNVLKSEQNDLRLQMEAQRI-----CLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
Query: 177 ILSQSQD-KSLRRIAELREELQMDQQAKKH------LQEEFDASLEEKDQYISVLQTQVS 229
I +Q + K L++I +L + Q+ L + ++ E+ Y LQT S
Sbjct: 1151 IFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF--LQTLCS 1208
Query: 230 LLKQRLRNGPMNVDVLK---PLPQLEPQAEVFTKEENPE-SDGEPVVEDGTSVKTLETLQ 285
+L G LK E + ++ E+PE D V+D + + TL
Sbjct: 1209 VL------GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ--ENMHTLL 1260
Query: 286 QRVKRQEN---LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ---ELEKIKDLHMA 339
+V + N +L+ I + L +E L ++ E L ++ ++D+ +
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
K+KL + K +E+ Q+ +I+ ++Q+ ET + E EI L+ R++ ++
Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS---- 1376
Query: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
+ + + S AQ+T +K +D I+ + +E ++ + L
Sbjct: 1377 ----ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLL 1432
Query: 460 SRVKQEVVD--VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT-----REREFQEQMK 512
+ QE ++ V K IA Q+ ++ ++ Q +E+ + +MK
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 513 VALE------------KSQSEYLKISQEKEQQESLAL------EELELQKKAILTESENK 554
++ + K + E+ +S+E + L ++ K +LT SE
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE-- 1550
Query: 555 LRDLQQEAETYRTR------ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
++ + +T+ R I + L N+ Q +D+ L + +H + ++
Sbjct: 1551 --EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELL 1608
Query: 609 VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHI 668
+ H ++E + Q+ L E+++ L +Q L ++ + E L+ ++E + +
Sbjct: 1609 RQAHMRQMERQREDQEQL-QEEIKRLNRQ-------LAQRSSIDNENLVSERERVLLEEL 1660
Query: 669 EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
E + + +L + EL + S++ + + ++EE+ + + + D+ +++ ++
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ-TFKEKELDRKPEDVPPEILSN 1719
Query: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
+ + Q+ ++ + + + + +T A+++ I + L + +R + ++ + I R
Sbjct: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS-------SKSQSSASLIWR 1772
Query: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYE----------------EQLAQLQQKL---- 828
SE E AS K V + + T E +Y E+ +L Q+L
Sbjct: 1773 SEAE---ASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829
Query: 829 -----LDLETERILLTKQVAEVEAQKK------DVCTELDAHKIQVQDLMQQLEKQNSEM 877
+D E E ++L A +K + ++L+ K+ +LM++ +Q E
Sbjct: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEA 1889
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI------------------------ 913
+ +K ++ E +L + ++ +EQ L + E +I
Sbjct: 1890 TESLKCQEELRE-RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRL 1948
Query: 914 ----------LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
LQ E ++++I+ + LS +++++ E + + +K+ K K +
Sbjct: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+ E ++ L Q L+ ++E + E++ N +++++ Q N A LE
Sbjct: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA--------LEK 2060
Query: 1024 NQKEQIESLTE--VHRRELNDVISIWEKKLNQQAE---ELQEIHEIQLQEKEQEVAELKQ 1078
++ + L E + R DV +KL QQ + Q I E Q +E EQ LK+
Sbjct: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE 2120
Query: 1079 K------ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK---------QKSAHVN 1123
K +LL KE++ ++I EE K + + EL++ L + H
Sbjct: 2121 KTDKCSELLL---SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG 2177
Query: 1124 SL-AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182
++ A+ E L+ L+ +++ KE T L+EQL + + E +V +L +L+
Sbjct: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237
Query: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI-QLDICCKKTEALLEAKTNELINISSS 1241
+E + E+ NK +D + +KL LAI + D + + +L K ++I
Sbjct: 2238 KESTTRLQELEQENKLFKD---DMEKLG--LAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2292
Query: 1242 KTNAILSRISHCQH--RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQL 1299
+ + + +++ Q + T + + K + +LE Q+ L +Q + + ++ QL
Sbjct: 2293 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL 2352
Query: 1300 EEKENQIK----------------------SMKADIESLVTEKEALQKEGGNQQQAASEK 1337
E +++ S+K ++ ++ EK AL++ Q + A+E+
Sbjct: 2353 NEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ----QVETANEE 2408
Query: 1338 ESCITQLKKELSENINAVTLMKEELKEKK---------------VEISSLSKQLTDLNVQ 1382
+ + + KE + +N +T LK ++ V I LSK +L V
Sbjct: 2409 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV 2468
Query: 1383 L-QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
L ++++ E + S + L ++ L V E +Q+ D +
Sbjct: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
Query: 1442 FSEWKKKAQSRFTQHQNTVKE-----LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD 1496
+ Q + Q V+E L Q++L++ + Y K Q N + + + +R +
Sbjct: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN---QTISSEPERTN 2585
Query: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556
++ + +E L +++ + T RI ELE + + + E ++ +K+
Sbjct: 2586 I--------QNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI--AEKN 2635
Query: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616
+ KE +KL Q+L E + + +E E+K + +V EL +E N
Sbjct: 2636 VLEKE--KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN---- 2689
Query: 1617 SKEEELKALEDRLESESA-AKLAELKRKAE--QKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
EL+AL R ES + A+LA K KAE Q+ +K+ ++ +++ Q + H
Sbjct: 2690 ----ELEAL--RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR----DH 2739
Query: 1674 LSELNTKLQ--EREREVHILEEKL------------KSVESSQSETLIVPRS-------A 1712
L+E KL E+E E + E K KS+ S TL + S
Sbjct: 2740 LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2799
Query: 1713 KNVAAYTE-QEEADSQGCVQ--KTYEEKISVLQ------------RNLTEKEKLLQR--- 1754
KN Q E S+ + + EKI +Q R+++E E L +
Sbjct: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYV 2859
Query: 1755 -VGQEKEETVSSHFEMRCQYQER---LIKLEHAEAKQHEDQSM------------IGHLQ 1798
V KEE + ++C + + +L H++A Q + + H Q
Sbjct: 2860 AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQ 2919
Query: 1799 ----------EELEEKNKKY-----SLIVAQHVEKEGGKNNIQAKQNLENVFDD-----V 1838
EE E + L+ A H E +Q E+ + D +
Sbjct: 2920 GFDIASEGRGEESESATDSFPKKIKGLLRAVHNE------GMQVLSLTESPYSDGEDHSI 2973
Query: 1839 QKT----LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY-----EKLQALQQ 1889
Q+ L+E++ + +K+L + + Q+E + + + E L ALQQ
Sbjct: 2974 QQVSEPWLEERKAYINTISS-LKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3032
Query: 1890 MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA--QHNDLEFKLAGA---EREKQKLGK 1944
+ + L TE + LL+ +E Q +E++ A + +++ L
Sbjct: 3033 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
Query: 1945 EIVRLQKDLR----MLRKEHQQEL---EILKKEYDQEREEKIKQEQEDLELKHNSTL--- 1994
EI L + L++E + E E+L+ Q++ + ++ + E +K +T
Sbjct: 3093 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3152
Query: 1995 -----KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049
K ++ E ++LAQ + ELE T+K AQ + LE+ + E ++ +
Sbjct: 3153 QLSSEKMVVAELKSELAQTKLELETTLK-----AQHKHLKELEAFRLEVKDKTDEVHLLN 3207
Query: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK-KYQQKLEQEENPGNDNVTIMEL 2108
D L K+ E+ A E+E R + EEL+ K+ + +++ N ++L
Sbjct: 3208 DTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN--------LQL 3259
Query: 2109 QTQLAQKTTLISDSKLKEQEFR---------EQIHNLE 2137
L Q+ L+++S+ K + R EQ NLE
Sbjct: 3260 NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLE 3297
Score = 203 bits (517), Expect = 1e-51
Identities = 389/2037 (19%), Positives = 850/2037 (41%), Gaps = 289/2037 (14%)
Query: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374
+++ + QL LQ+ + KD M E +L Q + + +QL+ + + +
Sbjct: 202 QRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA 261
Query: 375 ETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSE----RAAFEELEKALSTAQKTEEAR 430
+ L+ K+ Q+ + +Q+ Q L + ++K E + +F + + + ++ ++
Sbjct: 262 DLLQAKQ----QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVE 317
Query: 431 RKLKAEMDEQIKTIE----KTSEEERISLQQE---------LSRVKQEVVDVMKKSSEEQ 477
K E+ E+ IE K EEE+ +L+ + L +++++V +K+ E +
Sbjct: 318 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEIK 374
Query: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
KL+ + K+ R+ E K+L E Q++ K I Q EQ+ L
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN----HKDSQFETDIVQRMEQETQRKL 430
Query: 538 EEL-----ELQKKAILTESENKLRDLQQEAETYRTRIL-ELESSLE--KSLQENKNQSKD 589
E+L E+ + I+ + +R + E +TR E+E++L ++ N++Q K
Sbjct: 431 EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
Query: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL---R 646
+ V + E+ + ++ ++ E LK + + EK L++Q + +E+L R
Sbjct: 491 MNVAI--------NELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSR 541
Query: 647 EKCEQEKETLLKDKEIIFQAH--IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLE 704
E+ ++ ++T+ + + + +AH + + + E + ++ E +EV + KLE
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 705 ----EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI-- 758
E+ +VL + + ELE + H++++ + ++ E+ + + LKD +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 759 ---NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Q++ L E + ++ Q +NL I + + + S D+ QS ++ E+
Sbjct: 662 HYKQQIDGLQNEMSQKIETMQFEKDNL---ITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
Query: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
+L + + L E E+ L ++V E++ + + + ++ + +Q+ QLE +NS
Sbjct: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
Query: 876 EMEQKVKSLTQV--------YESKLEDGNKEQEQTKQILVEKE-NMILQMREGQKKEIEI 926
++ + K+L + E +L + + ++K + EKE ++++ E K++
Sbjct: 779 ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ 838
Query: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
L +++ + ++ + +E ++ +++ + + +++++ K+ L+ ++KLK E
Sbjct: 839 LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 987 NTALE------------LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
L+ + ++K F A+ LEM + ++ + +LE ++E++E
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE---- 954
Query: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
L+Q+ +L E QL++K E++ L +++ EKE+++
Sbjct: 955 ----------------LSQRLSDLSE----QLKQKHGEISFLNEEVKSLKQEKEQVSLRC 994
Query: 1095 TWLKEEGVKQDTTLNELQ-EQLKQKSAHVNSLAQDETKLKAHLEKLEVD-LNKSL-KENT 1151
L + +N + E ++ V+SL + + + V +NKS +E+
Sbjct: 995 REL-------EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
Query: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ E V + + ++ K +L + + SL+++ N L+ + K
Sbjct: 1048 IMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 1212 ELAIQLD---ICC-----------------KKTEALLEAKTNELINISSSKTNAILSRIS 1251
+L +Q++ IC +K +AL K ELI K L +I
Sbjct: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK-EELIFAQEEKIKE-LQKIH 1165
Query: 1252 HCQHRTTKVKEA--------LLI---KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
+ +T K +E LLI + E L+ L + E
Sbjct: 1166 QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE 1225
Query: 1301 EKENQ----IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
+KEN ++ +++ E + Q+ +E+ + + L+ LS+ T
Sbjct: 1226 DKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQT 1285
Query: 1357 ------LMKEELKEKKVEISSLSKQLT---DLNVQLQNSIS-------------LSEKEA 1394
+E L +++ E S+ Q+T D++V ++ +S + E E+
Sbjct: 1286 DGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345
Query: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
ISSL++Q E + ++ L ++ +S+ + VD S ++ ++ T
Sbjct: 1346 LISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVD------SVVITESDAQRT 1399
Query: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLK-------EELDQQNKRFDCLKGEMEDDKS 1507
+ + + I ++ + E+ N++K E+L+++ + ++
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459
Query: 1508 KMEKKESNLETELKSQTAR-IMELEDH------ITQKTIEIESLNEVLKNYNQQKDIEHK 1560
++ + E S+ A + + E H ++Q I ++ V + + E K
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE----EFK 1515
Query: 1561 ELVQKL-QHFQE--LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
L ++L +H +E L + + E+++ +LT+ +++S ++ + +++S
Sbjct: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
Query: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
+L E++LE + +L ++ +Q +++ + QME + E ++ + + L
Sbjct: 1576 ASRQLMLNEEQLE-DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ-LQEEIKRL 1633
Query: 1678 NTKLQER----------EREVHILE--EKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
N +L +R ERE +LE E LK + + E L +N + T+ +
Sbjct: 1634 NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCC--ELRNSSTQTQNGNEN 1691
Query: 1726 SQGCVQKTYEEK------ISVLQRNLTEKEKLLQRVGQE--------------KEETVSS 1765
++T++EK V L+ + LQ+ EET+
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 1766 HF------EMRCQYQERLIKLEHAEAK----QHE------DQSMIGHLQEELE------- 1802
H + Q LI AEA HE D+S+ + ++
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
K + ++Q + + G +N E + + + E + + + +L+
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNME 1922
V Q E+ R E K E ++L K E L E E+S++ LS E
Sbjct: 1872 KVTQTELMR---ESFRQKQEATESL-------KCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 1923 AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE------ 1976
+ + ER+ Q+ I RL+++L + QELE +++ +ERE
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQEL-LCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 1977 EKIKQEQEDLELKHNSTLKQLMR---EFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033
E +K E +E + ++LM+ E Q + +L+ +K +E + +E
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ-KL 2092
QE+ +L+ + +++ L++ ++ + LD E+ + + +E+QK QQ K+
Sbjct: 2041 EQEKNTELM-DLRQQNQALEKQLEKMRKFLD---EQAIDREHERDVFQQEIQKLEQQLKV 2096
Query: 2093 EQEENPGNDNVT--IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
P +++ T + +L L +KT S+ L +++ + I + ++K E V
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Score = 196 bits (498), Expect = 2e-49
Identities = 407/1957 (20%), Positives = 802/1957 (40%), Gaps = 379/1957 (19%)
Query: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRME--RSLSSYRGKYSELVTAYQMLQREKKKLQ 175
S+ S+ E L +E Q+ E + R + E A + L E K +
Sbjct: 1862 SETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921
Query: 176 GILSQSQD------KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS 229
G++ D + ++ ++ + L+ + + +E +A ++ + +L Q
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 230 LLKQRLRNGPMNVDVLKPLPQL-EPQAEVFTKEENPESDGEPVVEDGTSVKTLET-LQQR 287
+K GP+ +L+ +L + + EV + E D + VK LE ++++
Sbjct: 1982 AMKAEA--GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK------QVKALEIDVEEQ 2033
Query: 288 VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ 347
V R L + + ++Q L + E +++ LDE+ + E +D+ E KL Q
Sbjct: 2034 VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Query: 348 L--------------RDAKNLIEQLEQ--DKGMVIAETKRQMHETLEMKEEEIAQLRSRI 391
L R+ + L L++ DK + +K Q+ ++ + EEI +L R+
Sbjct: 2094 LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Query: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
+++ EQ F+++E + L+ ++ + I++ E+E
Sbjct: 2154 REL--------EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDR-KEKE 2204
Query: 452 RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ--- 508
+L+++L + ++E+ E + ++Q+LH +L +++E T +LQ E+E +
Sbjct: 2205 ITNLEEQLEQFREEL--------ENKNEEVQQLH-MQLEIQKKESTTRLQELEQENKLFK 2255
Query: 509 ---EQMKVALEKSQS-----------EYLKISQEKEQQESLALEELELQKKAILTESENK 554
E++ +A+++S + ++ +I QEKE + E++ ++ + ++NK
Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
Query: 555 L----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
+ +L ++ ET ++ + ++++ +E Q ++ L+ E ++ ++
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2375
Query: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
E +SLKHQ D + EKL L+QQ +T E++ KET K
Sbjct: 2376 SLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMKNVLKETNFK------------ 2422
Query: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ-- 728
MN+ T EL SL E V K + E ++V D K K ELE + E
Sbjct: 2423 MNQLT--------QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2474
Query: 729 KNHHQQ----------------------QVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
K+ Q Q++S + ++ + + K +KD Q + +
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2534
Query: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
K + Q VE A S+ +L+ Q Q+ + E + + L QL++
Sbjct: 2535 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2594
Query: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-----------------QDLMQQ 869
+L ++ LT +++E+E+Q ++ T L K QV Q L++
Sbjct: 2595 D--ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2652
Query: 870 LEKQNSEMEQK--------VKSLTQVYESKLEDG-----------------------NKE 898
EK+ E E+K +K+ T+++ S E G K
Sbjct: 2653 NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2712
Query: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK--- 955
++ +++LV++ NM +K++ + L+ ++ + IL +E ET+ + +K
Sbjct: 2713 EKLQEELLVKETNMT-----SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMF 2767
Query: 956 ----MEKVKQKAKEMQETLK-------KKLLDQEAKLKKELEN--TALELSQKEKQFNAK 1002
++ K A + TLK ++L + A ++ L++ ++ E+++ QF K
Sbjct: 2768 EPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK 2827
Query: 1003 MLEMAQANSAGISDAVSR----LETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAE 1056
+ +M + ++A I D SR ET ++E ++ + L VI K
Sbjct: 2828 IEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIP 2887
Query: 1057 ELQEIHEIQLQE--KEQEVAELKQKILL-----FGCEKEEMNKE---------------I 1094
EL Q +E ++ Q I L F E +E +
Sbjct: 2888 ELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLL 2947
Query: 1095 TWLKEEGVK------------QDTTLNELQEQ-LKQKSAHVNSLAQDE---TKLKAHLEK 1138
+ EG++ +D ++ ++ E L+++ A++N+++ + TK++ E
Sbjct: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 3007
Query: 1139 LEVDLNKSLKE-NTFLQEQLVELKMLAEEDKRKV-----SELTSKLKTTD---------E 1183
D ++S + + + E L+ L+ + E++ + +ELT+ L TTD +
Sbjct: 3008 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA-LGTTDAVGLLNCLEQ 3066
Query: 1184 EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT----EALLEAKTNELI--N 1237
Q ++ + + L+ K+ LSE A+ + +K E E + EL+ N
Sbjct: 3067 RIQEQGVEYQAAMECLQ-KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3125
Query: 1238 ISSSKTNAILSRI--SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
I ++ + ++ S + R T+++E L + V+EL+++L Q E T + +
Sbjct: 3126 IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH 3185
Query: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
+LE ++K K D L+ + A +++ + Q A EKE +E
Sbjct: 3186 LKELEAFRLEVKD-KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD------ 3238
Query: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
KEEL++ K + S ++ LN+ L Q L+E + I S R YD + E +Q
Sbjct: 3239 ---KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSE--EQG 3293
Query: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL----- 1469
++L +V L EK+ E + +EL QL+
Sbjct: 3294 RNLELQV-LLESEKVRIREMSSTLDRE-------------------RELHAQLQSSDGTG 3333
Query: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
+S+ ++ + L+++L++++ R L E E K K++ QT + ME
Sbjct: 3334 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE--KYKLD----------SLQTRQQME 3381
Query: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
+ + +KT++ E + N + + EL K++ Q EEK +V + L
Sbjct: 3382 KDRQVHRKTLQTE------QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK-----LD 3430
Query: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRK---AEQ 1646
LE Q L+ +E + L + K E + L L + L + + +Q
Sbjct: 3431 LEGQ------RLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
KI + E KE Y K L E+N E+ ++ +KL+ V S+
Sbjct: 3485 KI---------EGETKESNYAK-----LIEMNGGGTGCNHELEMIRQKLQCV---ASKLQ 3527
Query: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV-GQEKEETVSS 1765
++P+ A + E AD +E +Q N+ E LQ++ GQ+ EE
Sbjct: 3528 VLPQKASERLQF---ETAD---------DEDFIWVQENIDEIILQLQKLTGQQGEEPSLV 3575
Query: 1766 HFEMRC-QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI------VAQHVEK 1818
C ERL++ ++ + GH+ + EEKN +++ + + +
Sbjct: 3576 SPSTSCGSLTERLLR---------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3626
Query: 1819 EGGKNN-----IQAKQNLENVFDDVQKTLQEKELTCQ 1850
G++N + N+E + ++ ++LT Q
Sbjct: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQ 3663
Score = 129 bits (325), Expect = 2e-29
Identities = 297/1443 (20%), Positives = 604/1443 (41%), Gaps = 184/1443 (12%)
Query: 5 LKQKISEEQQQLQQALAPAQAS-SNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+K+ EE +QL + + Q +N T M + S +E+ D + + A
Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH--SLSEEADSLKHQLDVVIAEKLAL 2398
Query: 64 KLQLRVPSVESLF-RSPIKESLFRSS--SKESLVRTSSRESLNRLDL---DSSTASFDPP 117
+ Q+ + E F ++ +KE+ F+ + ++E RES+ ++ +S + D
Sbjct: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHL 2458
Query: 118 SDMDSEAEDLVGNSDSLN---------------KEQLIQRLRRMERSLSSYRGKYSELVT 162
S E E +V D+L K +I R+ + S+ K EL
Sbjct: 2459 SKDKPELE-VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2517
Query: 163 AYQMLQ--REKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQY 220
Y+ ++ +E+ + + + Q + +L++I E + + Q + +E+ A + +Q
Sbjct: 2518 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY-AKFCQDNQT 2576
Query: 221 ISVL--QTQVSLLKQRLRNGPMNVDVLK---PLPQLEPQA-----EVFTKEENPESDGEP 270
IS +T + L Q LR + D+ + +LE Q + ++E E +
Sbjct: 2577 ISSEPERTNIQNLNQ-LREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
Query: 271 VVEDGTSVKTLETLQQ--RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ 328
V+E + L+ L + K++E KR + ++ K L S +E+
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES------GFFN 2689
Query: 329 ELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR-QMHETLEMKEEEIAQL 387
ELE ++ +A K +L + A+ L E+L ++ ET + + L + +A+
Sbjct: 2690 ELEALRAESVATKAELASYKEKAEKLQEEL------LVKETNMTSLQKDLSQVRDHLAEA 2743
Query: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
+ ++ + + E E +E + FE L LS + ++ LK Q I
Sbjct: 2744 KEKLSILEKEDET--EVQESKKACMFEPLPIKLSKSIASQ-TDGTLKISSSNQTPQILVK 2800
Query: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF 507
+ +I+LQ E S +EV +++ + +E+ I K+Q+LH E+ E + +T +RE
Sbjct: 2801 NAGIQINLQSECS--SEEVTEIISQFTEK-IEKMQELHAAEILDMESRHISETETLKRE- 2856
Query: 508 QEQMKVALEKSQSEYLK-ISQEKEQQESLALEELELQKKAILTE--SENKLRDLQQEAET 564
+ V L K + LK + Q +E ++ EL E S + D Q
Sbjct: 2857 -HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYL 2915
Query: 565 YRTRILELESSLEKSLQENKNQS--KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
++ ++ S E+ S K + L A N+ + +++ + + Q
Sbjct: 2916 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2975
Query: 623 QDALWTEKLQVLKQQYQTEMEKLRE---KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
W E+ ++ Y + L++ K + ++E + D Q+H + + L
Sbjct: 2976 VSEPWLEE----RKAYINTISSLKDLITKMQLQREAEVYDSS---QSHESFSDWRGELLL 3028
Query: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
++Q LE S VL A + E D + LE ++ EQ +Q ++ +
Sbjct: 3029 ALQQVFLEERS-----VLLAAFRTELTALGTTDAVGLLNC-LEQRIQEQGVEYQAAMECL 3082
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K S+ +AL Q+N ++ LK + K Q E LE +I++ + ++ + +
Sbjct: 3083 QKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ---ELLEYNIQQKQSQMLEMQVE 3139
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKL----LDLETERILLTKQVAEVEAQKKDVCTE 855
L + + EQ + + +A+L+ +L L+LET K + E+EA + +V +
Sbjct: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
Query: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
D + + D + +K++ E++ ++ E +E E K L ++ LQ
Sbjct: 3200 TDEVHL-LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
Query: 916 MR---EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
+ E QK+ + QK+ ++ E + + + +E K + +EM TL
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL-- 3316
Query: 973 KLLDQEAKLKKELENTALE------------LSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
D+E +L +L+++ L + +KQ K + + + +
Sbjct: 3317 ---DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDS 3373
Query: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ--LQEKEQEVAELKQ 1078
L+T Q Q+E +VHR+ L E++ N + ++ ++HE+Q +++ ++++ E +Q
Sbjct: 3374 LQTRQ--QMEKDRQVHRKTLQT-----EQEANTEGQK--KMHELQSKVEDLQRQLEEKRQ 3424
Query: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN----------SLAQD 1128
++ E + + +G+ Q+ EL+ + K++S + SL D
Sbjct: 3425 QVYKLDLEGQRL---------QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
Query: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188
T+ +K+E + KE+ + + L+E+ ++ + KL+ + Q L
Sbjct: 3476 RTRNWVLQQKIEGET----KESNYAK--LIEMNGGGTGCNHELEMIRQKLQCVASKLQVL 3529
Query: 1189 --KSSHEKSNKSLEDKSLEFKKLS-EELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
K+S ++ +D+ + + + +E+ +QL + + + +
Sbjct: 3530 PQKASERLQFETADDEDFIWVQENIDEIILQL----------------QKLTGQQGEEPS 3573
Query: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE----- 1300
++S + C T E LL + +EL + QLTEE+N L + Q+
Sbjct: 3574 LVSPSTSCGSLT----ERLLRQN---AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3626
Query: 1301 --EKENQIK---SMKADIESLV-TEKEALQKEGGNQQQAASEKESCITQLKKELSENINA 1354
++N + + A+IE+++ +EKE +E Q++ E+ + +LK EL +
Sbjct: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3686
Query: 1355 VTL 1357
TL
Sbjct: 3687 QTL 3689
Score = 124 bits (310), Expect = 1e-27
Identities = 194/870 (22%), Positives = 379/870 (43%), Gaps = 122/870 (14%)
Query: 1357 LMKEELKEKKVEISSLSKQLTDLNVQL--QNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
+M+ EL K+ EI L+++L ++ V + L E EAAI KQ D +L +
Sbjct: 159 MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAI----KQRDGIITQLTANL 214
Query: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL----------Q 1464
Q + D +E + EQ +F + + R + H +T +L Q
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 1465 IQLELKSK--EAYEKDE-----QINLLKE-----ELDQQNKRFDCLKGEMEDDKS----- 1507
QLE + E Y+K + QI+ L+E E++Q K + K E+++ ++
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 1508 -----KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
+ EKK L+ +L + + EL++ I QK EI+++ L N Q++ +E+
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
Query: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622
Q + +EL ++++++ + E I+ Q K LE + EL+ + +++
Sbjct: 395 KQLMGTVEEL-QKRNHKDSQFETDIVQRMEQETQRK--LEQLRAELDEMY------GQQI 445
Query: 1623 KALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQ 1682
++ L + A++ E+K + + ++ + S + E+Q K + ++ELN KLQ
Sbjct: 446 VQMKQELIRQHMAQMEEMKTRHKGEMENALRSY-SNITVNEDQIKLMNVA-INELNIKLQ 503
Query: 1683 EREREVHILEEKL------KSVESSQSETLIVPRS--------AKNVAAYTEQEEADSQG 1728
+ + L+E+L K Q E L+ S A+ A E + ++
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE--------RLIKL 1780
+ + K ++ + + KE L K E ++++++ + E R+ +
Sbjct: 564 SLSTVEDLKAEIVSASESRKELEL------KHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
Query: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
+ AE ++ Q + H +EEL + + + ++EK I KQ ++ + +++ +
Sbjct: 618 QEAELERLRTQLLFSH-EEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
Query: 1841 TLQ----EKE--LTCQ---ILE-QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA-LQQ 1889
++ EK+ +T Q ILE K+K+L LV K EE+T + +LQ ++
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS------EEMTLQINELQKEIEI 730
Query: 1890 MDGRNKPTELLEENTEE-KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
+ K LE+ +E + K+ L++ + M+ + NDL+ K A E E L E
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQ----MKEKENDLQEKFAQLEAENSILKDEKKT 786
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+ L++ Q+E I + ++ + +++ ++ ++ N LKQ + N ++ ++
Sbjct: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
K QE+ QEE LLK + +D + Y+ L A E
Sbjct: 847 RNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE 898
Query: 2069 EM------TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL-------QTQLAQK 2115
E+ V+ + +E + + LE E D +ME + +L+Q+
Sbjct: 899 ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 2116 TTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
+ +S+ +LK++ N E + K EK
Sbjct: 959 LSDLSE-QLKQKHGEISFLNEEVKSLKQEK 987
Score = 111 bits (277), Expect = 9e-24
Identities = 151/689 (21%), Positives = 314/689 (45%), Gaps = 89/689 (12%)
Query: 1467 LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
LE+ E K +I L EL++ + + + K+ + T+L + +
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
+D ++ +E+ ++ L+ QQ ++ E ++ H + + +A+++
Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQ--LQASETLRNSTHSSTAAD-----LLQAKQQ 269
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
ILT + Q+ LE +K+ E + + +E++K E E +K E
Sbjct: 270 ILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----------MEQDKKVEN 318
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS----Q 1702
S EE +E+ E+ + ELNTK+ E E++ L++KL + + Q
Sbjct: 319 ----------SNKEEIQEK-----ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQ 363
Query: 1703 SETLIVPRSAKNVA---AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE---KLLQRVG 1756
+ + + KN+ ++Q+E S +++ + +RN + + ++QR+
Sbjct: 364 EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME 423
Query: 1757 QEKEETVSS-HFEMRCQYQERLIKLEHAEAKQHEDQ--SMIGHLQEELEEKNKKYSLIVA 1813
QE + + E+ Y +++++++ +QH Q M + E+E + YS I
Sbjct: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483
Query: 1814 QHVEKEGGKNNIQAKQ-NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV 1872
E + N+ + N++ + QK ++EL ILE+K L RQ E
Sbjct: 484 N--EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL-ILEEKC-----ALQRQLEDL-- 533
Query: 1873 EMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
+EEL+ E++Q +Q + L E + S ++ +++S E++ +LE K
Sbjct: 534 -VEELSFSREQIQRARQTIAEQESK--LNEAHKSLSTVEDLKAEIVSASESR-KELELKH 589
Query: 1933 AGAEREKQKLGKEIVRLQKD--LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
AE K+ E++ +K+ L + + + ELE L+ + EE++ + +EDLE++H
Sbjct: 590 E-AEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH 648
Query: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
+++L + L + K+ I+ Q ++ +E+ Q E + L+ K +
Sbjct: 649 RINIEKL-----------KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK--LEQEENPGNDNVTIMEL 2108
++ + + +++++ EEMT ++ +LQ ++E L+++ ++K LEQE V ++L
Sbjct: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE-------VQELQL 750
Query: 2109 QTQLAQKTTLISDSKLKEQEFREQIHNLE 2137
+T+L +K K KE + +E+ LE
Sbjct: 751 KTELLEK-----QMKEKENDLQEKFAQLE 774
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 227 bits (578), Expect = 1e-58
Identities = 311/1320 (23%), Positives = 581/1320 (44%), Gaps = 239/1320 (18%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+++Q+LT ++ +R +K+ + + K+ Q Q+E + +E
Sbjct: 794 LARKAFAKRQQQLTA-MKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEE 852
Query: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
EL K +R+ Q AE R+ E+E+ L+ L K Q ++ + E E
Sbjct: 853 ELVK----------VREKQLAAEN---RLTEMET-LQSQLMAEKLQLQE-QLQAETELCA 897
Query: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
+E+ + K ELE + H +A +E+ E+C+ L+ +
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEA---------------RVEEEEERCQH-----LQAE 937
Query: 661 EIIFQAHIEEMNEKTLEKLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719
+ Q +I+E+ E+ E+ +Q +LE +++E LK KLEEE +L+DQ K+ +
Sbjct: 938 KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK--LK---KLEEEQIILEDQNCKLAK 992
Query: 720 E---LEAKMDE------QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
E LE ++ E ++ + + + +HE I E+ L+ + Q + L K R K
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 771 ----------HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
+ E QA + L+ + + E ELQ A A+++ + ++ ++ + E Q
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQD--------------- 865
+++LQ+ DLE+ER K E QK+D+ EL+A K +++D
Sbjct: 1113 ISELQE---DLESERASRNK----AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 866 ------LMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKENMILQMR 917
L + LE++ E +++ + Q + +E+ ++ EQTK++ +EK L+
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 918 EGQ-KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD 976
G+ E+++L Q K DS H K K E ++++++ K E E ++ +L D
Sbjct: 1226 RGELANEVKVLLQ---GKGDSEH--------KRKKVEAQLQELQVKFNE-GERVRTELAD 1273
Query: 977 QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH 1036
+ KL+ EL+N LSQ + + S+ ++ S LE+ ++ E L E +
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSK------------SSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE--- 1093
R++L+ KL Q +E E QL+E+E+ L+++I + +M K+
Sbjct: 1322 RQKLS-----LSTKLKQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 1094 ----ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKE 1149
+ +E K L L ++ ++K A + L + +T+L+ L+ L VDL+ +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
L E+ ++K +L ++ KT ++ + E + E K+L +
Sbjct: 1436 ACNL-----------EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
EE Q + E L + E+ ++ SSK + + H K K AL +
Sbjct: 1485 LEEAMEQK----AELERLNKQFRTEMEDLMSSKDD-----VGKSVHELEKSKRALEQQ-- 1533
Query: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEK-ENQIKSMKADIESLVTEKEALQKEGG 1328
V E++ QL +L +E QAT + + E +++MKA E LQ G
Sbjct: 1534 -VEEMKTQLEELEDEL--------QATEDAKLRLEVNLQAMKAQFE------RDLQ---G 1575
Query: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
+Q+ +K+ + Q+++ +E +++E K++ + +++ K DL
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAE-------LEDERKQRSMAVAARKKLEMDLK-------- 1620
Query: 1389 LSEKEAAISSLRKQYDE---EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+ EA I S K DE + +L Q++D ++D + L Q E
Sbjct: 1621 --DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA-------KEN 1671
Query: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME-D 1504
+KK +S + +EL K + E+DE L +E+ + KG + +
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE----LADEIANSSG-----KGALALE 1722
Query: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL----------KNYNQQ 1554
+K ++E + + LE EL+ + + D + + ++I+ +N L +N QQ
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
+ ++KEL KLQ + + K + I LE ++ ++ +L+ + KE +
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSK------YKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES-- 1672
V+ E++LK + L+ + + AE + K + KQL Q+EE EE+ ++ S
Sbjct: 1837 VRRTEKKLKDV--LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Query: 1673 ----HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVP-RSAKNVAAYTEQEEADSQ 1727
L + REV L+ KL+ + +VP R A+ A EE D +
Sbjct: 1895 KLQRELEDATETADAMNREVSSLKNKLRRGDL----PFVVPRRMARKGAGDGSDEEVDGK 1950
Score = 193 bits (490), Expect = 2e-48
Identities = 265/1186 (22%), Positives = 518/1186 (43%), Gaps = 153/1186 (12%)
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELEN-----------TALELSQKEKQFNAKMLEMAQ 1008
K AK Q+ K+L + +L N L++S++E++ AK E+ +
Sbjct: 797 KAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVK 856
Query: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQE 1068
++ A +RL + E ++S + +L + + E +L +AEEL+ + QE
Sbjct: 857 VREKQLA-AENRL--TEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQE 912
Query: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
E+ +L+ ++ EE + L+ E K + EL+EQL+++ + L +
Sbjct: 913 LEEICHDLEARV-------EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLE 965
Query: 1129 ETKLKAHLEKLEV------DLN-KSLKENTFLQEQLVEL--KMLAEEDKRK--------- 1170
+ +A L+KLE D N K KE L++++ E + EE+K K
Sbjct: 966 KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 1171 ---VSELTSKLKTTDEEFQSLKSSHEK---SNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
+++L +L+ +++ Q L+ + K + L D+ E + EL +QL KK
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKE 1082
Query: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
E L A + +++ N L +I + + ++++E L + + ++ E Q R L EE
Sbjct: 1083 EELQAALAR--VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + ++ + ++ L K+ L++E + E +Q
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNIL---KKTLEEEAKTHEAQIQEMRQKHSQA 1197
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLT-DLNVQLQNSISLSEK----EAAISSL 1399
+EL+E + +K L++ K + + +L ++ V LQ K EA + L
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 1400 RKQYDEE---KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH 1456
+ +++E + EL D+V L ++D ++ L Q D S+K ++ +S+
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVT----GLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 1457 QNTVKELQIQ-LELKSKEAYEKDEQINLLKEELDQQN-------KRFDCLKGEMEDDKSK 1508
Q ++E Q L L +K +DE+ N +E+L+++ K+ L ++ D K K
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEK-NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 1509 MEKKESNLET--ELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKD-----IEHK 1560
ME LET E+K + + +E L +K + L + Q+ D ++H+
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 1561 E-----LVQKLQHFQEL-----------GEEKDNRVKEAEEKILTLENQVYSMKAELET- 1603
L +K + F +L EE+D EA EK E + S+ LE
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK----ETKALSLARALEEA 1488
Query: 1604 --KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE 1661
+K ELE +N +++ E+L + +D + +S +L + KR EQ++ +K QL EE
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDV-GKSVHELEKSKRALEQQVEEMKTQL----EE 1543
Query: 1662 KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV-ESSQSETLIVPRSAKNVAAYTE 1720
E++ + TE L LQ + + E L+ E S+ + + R + + A E
Sbjct: 1544 LEDELQ-ATEDAKLRLEVNLQAMKAQ---FERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Query: 1721 QEEADSQGCVQ---------KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC 1771
E V K E I +N E K L+++ + ++ + + R
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELE--EKNKKYSLI----VAQHVEKEGGKNNI 1825
+E L + + E K ++ + LQEEL E+ K+ + +A + GK +
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 1826 --QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
+ K+ LE +++ L+E++ +++ ++K+ + ++ +++ E + +
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN---LQIDQINTDLNLERSHAQKN 1776
Query: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
A QQ++ +NK ++ + E KS ++ +EA+ LE +L +E+Q
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKAS--ITALEAKIAQLEEQLDNETKERQAAC 1834
Query: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT 2003
K++ R +K L+ ++L + D+ R + ++Q D K ++ LKQL R+
Sbjct: 1835 KQVRRTEKKLK----------DVLLQVDDERRNAEQYKDQAD---KASTRLKQLKRQL-- 1879
Query: 2004 QLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049
+ A++E + + + + E E ++ E + L K+ D
Sbjct: 1880 EEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Score = 175 bits (444), Expect = 4e-43
Identities = 254/1166 (21%), Positives = 511/1166 (43%), Gaps = 154/1166 (13%)
Query: 132 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191
+ + KE+ + ++R E+ L++ + +E+ T L EK +LQ L Q++ + E
Sbjct: 846 EMMAKEEELVKVR--EKQLAA-ENRLTEMETLQSQLMAEKLQLQEQL-QAETELCAEAEE 901
Query: 192 LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQL 251
LR L +Q + + + +A +EE+++ LQ + ++Q ++ ++ + Q
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 252 EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
+V T+ + + + E ++ + + K L + K E+ + + +E+
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCK----LAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017
Query: 312 LTSEK---EALQEQLDERL-------QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQD 361
L K EA+ L+ERL QELEK + + T L Q+ + + I +L+
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK-- 1075
Query: 362 KGMVIAETKRQMHETLEMKEEEIAQLR---SRIKQMTTQGEELRE----------QKEKS 408
M +A+ + ++ L EEE AQ +I+++ +Q EL+E + EK
Sbjct: 1076 --MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 409 ERAAFEELEKALSTAQKTEE---ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE 465
+R EELE + + T + A+++L+++ ++++ ++KT EEE + + ++ ++Q+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193
Query: 466 VVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER-EFQEQMKVALE-KSQSEYL 523
+++ +E+ L + + + E K+ ER E ++KV L+ K SE+
Sbjct: 1194 HSQAVEELAEQ-------LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 524 KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE------------ 571
+ E + QE L+ + + + TE +K+ LQ E + + +
Sbjct: 1247 RKKVEAQLQE---LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 572 --LESSLEKS---LQENKNQSKDLAVHL---EAEKNKHNKEITVMVE-KHKTELESLKHQ 622
LES L+ + LQE Q L+ L E EKN +++ E KH E +
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE------K 1357
Query: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN-----EKTLE 677
Q A ++ +K++ + + L E E+ K L KD E + Q H E++ EKT
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCL-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 1416
Query: 678 KLDVKQTELESLSSELSEVLKARHKL------------EEELSVLKDQTDKMKQELEAKM 725
+L Q EL+ L +L ++ L EE+ K ++ + E EA+
Sbjct: 1417 RL---QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
E K + E + ++R K + ++ L + K + E + LE
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ-LQQKLLDLETERILLTKQVAE 844
++ + +L++ +L + + +A + Q + LQ + E ++ L +QV E
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 845 VEA----QKKDVCTELDAHK---IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
+EA ++K + A K + ++DL ++ N ++ +K L ++ +++++D +
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-QAQMKDCMR 1652
Query: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME 957
E + T+ +E ++ Q +E +KK + + + +E+ + + + + E E
Sbjct: 1653 ELDDTR---ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 958 KVKQKAK-----EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM------LEM 1006
K E + L+ ++ E +L++E NT L ++ + K+ N ++ L +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL-INDRLKKANLQIDQINTDLNL 1768
Query: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVH---RRELNDVISIWEKKLNQQAEEL-QEIH 1062
++++ +A +LE KE L E+ + + I+ E K+ Q E+L E
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV 1122
E Q K+ E K K +L + E N E K++ K T L +L+ Q
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAE--QYKDQADKASTRLKQLKRQ-------- 1878
Query: 1123 NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182
LE+ E + ++ LQ +L + A+ R+VS L +KL+ D
Sbjct: 1879 -------------LEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Query: 1183 EEF-----QSLKSSHEKSNKSLEDKS 1203
F + K + + S++ ++ K+
Sbjct: 1926 LPFVVPRRMARKGAGDGSDEEVDGKA 1951
Score = 161 bits (407), Expect = 8e-39
Identities = 229/1123 (20%), Positives = 493/1123 (43%), Gaps = 142/1123 (12%)
Query: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE 1155
W VK ++ +E++ K + + + + + L ++E ++ + E LQE
Sbjct: 828 WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
QL L E + + LT+K + +E L++ E+ + + E KK+ + +
Sbjct: 888 QLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI-- 945
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELE 1275
++ E LE + S++ L +++ + + K++E +I LE
Sbjct: 946 ------QELEEQLEEE-------ESARQKLQLEKVT-TEAKLKKLEEEQII-------LE 984
Query: 1276 AQLRQLTEEQNTLNISFQQATHQLEEKENQIKSM---KADIESLVTEKEALQKEGGNQQQ 1332
Q +L +E+ L + T L E+E + KS+ K E+++T+ E + Q+Q
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ 1044
Query: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
+L+K + T + +++ E + +I+ L QL +LQ +++ E+
Sbjct: 1045 ----------ELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094
Query: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
EAA ++ + E L Q+ +L +++ + A +Q D + K
Sbjct: 1095 EAAQKNMALKKIRE---LESQISELQEDLESERASRNKAEKQKRDLGEELEALK------ 1145
Query: 1453 FTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKK 1512
T+ ++T+ Q EL+SK +++++N+LK+ L+++ K + EM S+ ++
Sbjct: 1146 -TELEDTLDSTAAQQELRSK----REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
Query: 1513 ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572
+ + K A + + + + + E+ + +VL + + K++ +LQ Q
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260
Query: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632
E + E +K+ L+ ++ ++ L + + + E +L+ ++ L+ E
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
+ KL+ L K +Q + K Q+EE EE+ K E ++ L+ ++ + ++++
Sbjct: 1321 NRQKLS-LSTKLKQ-VEDEKNSFREQLEE-EEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 1693 EKLKSVESSQSETL-----IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR---- 1743
L++ E + + + R + VAAY + E+ ++ +Q+ ++ + L
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR--LQQELDDLLVDLDHQRQS 1435
Query: 1744 --NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
NL +K+K ++ E E+T+S+ + +ER + AEA+ E ++ L L
Sbjct: 1436 ACNLEKKQKKFDQLLAE-EKTISAKYA-----EER----DRAEAEAREKETKALSLARAL 1485
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF---DDVQKTLQEKELTCQILEQKIKE 1858
EE A + E + N Q + +E++ DDV K++ E E + + LEQ+++E
Sbjct: 1486 EE---------AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 1859 LDSCLVR-QKEVHRVEMEELTSKYE----KLQALQQMDGRNKPTE-----------LLEE 1902
+ + L + E+ E +L + K Q + + GR++ +E +E
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1596
Query: 1903 NTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ----------KD 1952
E++ K + +E DLE + A + + + K++ +LQ D
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDD 1656
Query: 1953 LRMLR-------KEHQQELEILKKEYDQEREE---------KIKQEQEDL--ELKHNSTL 1994
R R KE++++L+ ++ E Q +EE + +QE+++L E+ ++S
Sbjct: 1657 TRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGK 1716
Query: 1995 KQL----MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETN-QLLKKIAEKD 2049
L R ++AQ E+ELE T ++ L+ Q T+ L + A+K+
Sbjct: 1717 GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN 1776
Query: 2050 DDLKRTAKRYEEILDAREEEMTAKVRD-LQTQLEELQKKYQQKLEQEENPGNDNVT---- 2104
++ ++ +R + L + +EM V+ + + L+ K Q EQ +N +
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 2105 IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
+ + +L + D + +++++Q RLK+ ++ +
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879
Score = 61.2 bits (147), Expect = 1e-08
Identities = 101/483 (20%), Positives = 201/483 (41%), Gaps = 111/483 (22%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
+ L+Q++ E + QL++ QA+ ++ R+ + Q + R D QS
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKL--RLEVNLQAMKAQFERDLQGR---DEQSEE 1582
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
+K QL V V + E+ K+ + ++R+ L +DL A D
Sbjct: 1583 KKKQL-VRQVREM------EAELEDERKQRSMAVAARKKLE-MDLKDLEAHID------- 1627
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRME-------RSLSSYRGKYSELVTAYQMLQREKKKLQ 175
S + N+++ I++LR+++ R L R E++ + +KKL+
Sbjct: 1628 --------SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA---QAKENEKKLK 1676
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFD--------------ASLEEKDQYI 221
+ ++ + +L+EEL ++AK+ Q+E D +LEEK +
Sbjct: 1677 SMEAE--------MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR-- 1726
Query: 222 SVLQTQVSLLKQRLRNGPMNVDVLKP-LPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
L+ +++ L++ L N +++ L + Q + + N E E+
Sbjct: 1727 --LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 281 LETLQQRVKRQENLLKRCKETIQS-HKEQCTLLTSEKEALQEQLDERLQELE-KIKDLHM 338
+ + +VK QE + T++S +K T L ++ L+EQLD +E + K +
Sbjct: 1785 RQNKELKVKLQE-----MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR 1839
Query: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG 398
EK K+++ Q++ ++ E +++ + +R+KQ+ Q
Sbjct: 1840 TEK--------KLKDVLLQVDDER------------RNAEQYKDQADKASTRLKQLKRQL 1879
Query: 399 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
EE E+ AQ+ +RRKL+ E+++ +T + + E SL+ +
Sbjct: 1880 EEAEEE------------------AQRANASRRKLQRELEDATETADAMNREVS-SLKNK 1920
Query: 459 LSR 461
L R
Sbjct: 1921 LRR 1923
Score = 41.6 bits (96), Expect = 0.009
Identities = 50/248 (20%), Positives = 109/248 (43%), Gaps = 24/248 (9%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPT--RMRSRTSSFTEQLDEGTPNRESGDTQS 60
++ K++ +E+ +L +A + + R+ +R + E+L+E E G+T+
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE-----EQGNTEL 1747
Query: 61 FAQKLQ---LRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117
+L+ L++ + + + ++++ L R + + +++ + S
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 118 SDMDSEAE--DLVGNSDSLNKEQ--LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKK 173
S EA+ L D+ KE+ +++RR E+ L + + + E+ K
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-----ERRNAEQYK 1862
Query: 174 LQGILSQSQDKSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLK 232
Q + ++ K L+R + E EE Q +++ LQ E + + E D + +VS LK
Sbjct: 1863 DQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD----AMNREVSSLK 1918
Query: 233 QRLRNGPM 240
+LR G +
Sbjct: 1919 NKLRRGDL 1926
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 224 bits (570), Expect = 1e-57
Identities = 316/1326 (23%), Positives = 584/1326 (44%), Gaps = 240/1326 (18%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+++Q+LT ++ +R +K+ + + K+ Q Q+E + +E
Sbjct: 801 LARKAFAKRQQQLTA-MKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKED 859
Query: 541 ELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
ELQK K ++EN+L++L+Q+ +++ E ++ L++ LQ + ++ EAE
Sbjct: 860 ELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQA------ETELYAEAE-- 907
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
E+ V + K ELE + H+ +A E+ + QQ Q E +K+ ++ +E L
Sbjct: 908 ----EMRVRLAAKKQELEEILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQL--- 959
Query: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719
E E +KL +++ E+ KLE+E+ V+ DQ +K+ +
Sbjct: 960 ----------EEEEAARQKLQLEKVTAEAKIK----------KLEDEILVMDDQNNKLSK 999
Query: 720 ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK------ 773
E K L+++I+ L L E ++ K
Sbjct: 1000 E------------------------------RKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 774 -EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
+H++ + LE +K+ E Q+ + S HEQ + Q+A+L+ +L E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 833 TE--------------RILLTKQVAEVEAQKKDVCTELDAHKI-------QVQDLMQQLE 871
E + K++ E+E D+ +LD+ + Q +DL ++LE
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQT--KQILVEK----ENMILQMREGQKKEIE 925
+E+E + S E + +EQE T K+ L E+ E + +MR+ + +E
Sbjct: 1150 ALKTELEDTLDSTATQQELR---AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 926 ILTQKLSAKEDSIHILNEEYETKFK-NQEKKME-KVKQKAKEMQETLKKKLLDQEAKLKK 983
LT++L + + L++ +T K N + E +V +AK+ E KKKL Q +L+
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 984 EL---ENTALELS------QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
+ E EL+ Q E + ML A+ + ++ V+ L + ++ E L E
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
R++LN +S ++L ++ LQ+ QL E+ + L++ I + + K++
Sbjct: 1327 ETRQKLN--VSTKLRQLEEERNSLQD----QLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 1095 ------TWLKEEGVKQ-DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
EEG K+ + L +Q ++K+A + L + + +L+ L+ L VDL+
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-- 1438
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Q QLV E+ +RK +L ++ K ++ + E + E K+L
Sbjct: 1439 ------QRQLVS---NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
+ EE A++ ++T +L+A+ +L+ SSK + + H K K A
Sbjct: 1490 RALEE-ALEAKEELERTNKMLKAEMEDLV---SSKDD-----VGKNVHELEKSKRA---- 1536
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327
LE Q+ EE T QLEE E+++++ + L +AL+ +
Sbjct: 1537 ------LETQM----EEMKT----------QLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 1328 GNQQQAASEK-ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL-NVQLQN 1385
QA E+ E QL+++L E T +++E K++ + ++ K DL +++LQ
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHE---YETELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Query: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
++ +E AI LRK L ++ +E A D+ E
Sbjct: 1634 DSAIKGREEAIKQLRK---------------LQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
+KKA+S +Q+Q +L + E K Q +L KEEL ++ + ++D+
Sbjct: 1679 EKKAKSL------EADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNALQDE 1730
Query: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL----------KNYNQQK 1555
K ++E + + LE EL+ + + + D + + T + E L+ L ++ QQ
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 1556 DIEHKELVQKLQHFQELGEEKDNRVK-EAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
+ ++KEL KL E + VK + + I LE ++ ++ ++E + +E + S
Sbjct: 1791 ERQNKELRSKL-------HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ------YKK 1668
+K K+++LK E L+ E K+AE ++ +K A KQL Q+EE EE+ ++
Sbjct: 1844 LKQKDKKLK--EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1669 GTESHLSELNTKLQEREREVHILEEKLKS------VESSQSETLIVPRSAKNVAAYTEQE 1722
+ L E + REV+ L+ KL+ V S +S V +A T+
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTR 1961
Query: 1723 EADSQG 1728
+AD G
Sbjct: 1962 DADFNG 1967
Score = 209 bits (531), Expect = 3e-53
Identities = 273/1225 (22%), Positives = 538/1225 (43%), Gaps = 172/1225 (14%)
Query: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
K + + Q+ + ++M + +EL++ KE+ ++A E E +Q TEE + L E +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--KNLLQEQLQ 897
Query: 440 QIKTIEKTSEEERISL---QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
+ +EE R+ L +QEL +E++ M+ EE+ + Q+L + +Q L
Sbjct: 898 AETELYAEAEEMRVRLAAKKQEL----EEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 497 TKKLQTREREFQEQMKVALEK--SQSEYLKISQE---------KEQQESLALEELELQKK 545
+ Q E E Q K+ LEK ++++ K+ E K +E LEE
Sbjct: 954 DLEEQLEEEEAARQ-KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605
L E E K ++L + + + I ELE L+K ++++ + + L LE + + +++I
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 606 TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
+ + ++ LK Q L +++ Q + +L ++ Q+ L K +E+ +
Sbjct: 1072 ADL----QAQIAELKMQ--------LAKKEEELQAALARLDDEIAQKNNALKKIREL--E 1117
Query: 666 AHIEEM-----------NEKTLEKLDVKQTELESLSSELSEVL-------KARHKLEEEL 707
HI ++ N+ +K D+ + ELE+L +EL + L + R K E+E+
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEV 1176
Query: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
+VLK D+ + EA++ E + H Q V+ + ++ E +R + L LE +
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENAD 1235
Query: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
L+ + +E K+ E ++Q+ +K + ++ +++ + ++ +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
L + E + I L K VA + +Q +D Q+L+Q+ +Q + K++ L +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQD-----------TQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKK------EIEILTQKLSAKEDSIHIL 941
S + ++E E + + + +Q+ + +KK +E L + + I L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
++YE K + K+EK K + ++ + L LD + +L LE +K+++F+
Sbjct: 1405 TQQYEEKAAAYD-KLEKTKNRLQQELDDLVVD-LDNQRQLVSNLE-------KKQRKFDQ 1455
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ E +S +D R E +E+ E K A L+E
Sbjct: 1456 LLAEEKNISSK-YADERDRAEAEAREK-------------------ETKALSLARALEEA 1495
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
E + +E E+ LK ++ K+++ K + L++ +T + E++ QL++
Sbjct: 1496 LEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSL--------KENTFLQEQLVELKMLAEEDKRK--- 1170
+ + + +L+ +++ L+ + L ++ LQ QL E + E+++++
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 1171 ----VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
+L LK + + S E++ K L + K EL D + E
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE---DARASRDEI 1671
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKV----KEALLIKTCTVSELEAQL---R 1279
AK NE K ++ + + Q K+A L K EL + L
Sbjct: 1672 FATAKENE------KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
L +E+ L Q +LEE++ +++M + + E L E ++ A + ES
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785
Query: 1340 CITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
QL+++ E + + M+ +K K K I++L ++ L Q++ EK+AA S
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKS 1843
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
L KQ D++ E+L QV+D + K+ + ++ E +K +R
Sbjct: 1844 L-KQKDKKLKEILLQVED---------ERKM---------AEQYKEQAEKGNAR------ 1878
Query: 1459 TVKELQIQLELKSKEAYEKDEQINL----LKEELDQQNKRFDCLKGEMEDDKSKMEK-KE 1513
VK+L+ QLE EA E+ ++IN L+ ELD+ + + + E+ KSK+ + E
Sbjct: 1879 -VKQLKRQLE----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Query: 1514 SNLETELKSQTARIMELEDHITQKT 1538
++ +S R++E D ++T
Sbjct: 1934 TSFVPSRRSGGRRVIENADGSEEET 1958
Score = 188 bits (477), Expect = 6e-47
Identities = 270/1194 (22%), Positives = 528/1194 (44%), Gaps = 158/1194 (13%)
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELEN-----------TALELSQKEKQFNAKMLEMAQ 1008
K AK Q+ K++ + +L N L+++++E++ AK
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------ 857
Query: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAEELQEIHE--I 1064
D + + + Q++ L E+ ++ +L + ++ +++L + E E E +
Sbjct: 858 ------EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
+L K+QE+ E+ ++ E+E+ ++ L+ E K + +L+EQL+++ A
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 1125 LAQDETKLKAHLEKLEVDL-------NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
L ++ +A ++KLE ++ NK KE L+E++ +L E++ K LT K
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-K 1027
Query: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
LK E S+ S E K E E +KL +L ++ A L+A+ EL
Sbjct: 1028 LKNKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQIAELKM 1083
Query: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
+ K + + ++ + AL + ELE + L E+ ++ + +A
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKA-- 1137
Query: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
E Q + + ++E+L TE E QQ+ +++E +T LKK L E +
Sbjct: 1138 -----EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 1358 MKEELKEKKVE-ISSLSKQLTDLN---VQLQNSISLSEKEAA--------ISSLRKQYDE 1405
+E+++K + + L++QL L + EKE A + +++ +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1406 EKCELLDQVQDLSFKVDTLSK------EKISALE-QVDDWSNKFSEWKKKAQSRFTQHQN 1458
+K +L QVQ+L K + +K+ L+ +V+ + +E + KA +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
+LQ EL +E +K L++ +++N D L EME K +E+ S L
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNI 1371
Query: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH--KELVQKLQHFQELGEEK 1576
+L ++ + +E+L E K + QK+IE+ ++ +K + +L + K
Sbjct: 1372 QLSDSKKKLQDFAS-------TVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHV-----NLSVKSKEE----ELKALED 1627
+ +E ++ ++ L+NQ + + LE K+++ + + N+S K +E E +A E
Sbjct: 1423 NRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSE--LNTKL 1681
++ S A+ E +A++++ K L ++ME+ K++ K E S+ L T++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
+E + ++ LE++L++ E ++ R N+ A Q E D Q ++ EEK L
Sbjct: 1542 EEMKTQLEELEDELQATEDAKL------RLEVNMQALKGQFERDLQARDEQN-EEKRRQL 1594
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
QR L E E L+ + K+ +++ + + + + ++L+ D ++ G
Sbjct: 1595 QRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGR----- 1640
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EE K+ + AQ + + + +A + D++ T +E E + LE + +L
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASR------DEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 1862 CLV------RQKEVHRVEM-EELTSKYEKLQALQQMDGRNKPT-ELLEENTEEKSKSHLV 1913
L +Q ++ + E+ EEL S ALQ R + LEE EE+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ----- 1749
Query: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
NMEA + + AE+ +L E QK+ + +Q+LE KE
Sbjct: 1750 -----GNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-----ESARQQLERQNKEL-- 1797
Query: 1974 EREEKIKQEQEDLELKHNSTLKQL---MREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
K+ + + ++ K ST+ L + + Q+ Q+ +E + K K ++++ L
Sbjct: 1798 --RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 2031 LESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
L+ E + + K+ AEK + + KR E + + + A R LQ +L+E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 186 bits (472), Expect = 2e-46
Identities = 256/1157 (22%), Positives = 514/1157 (44%), Gaps = 137/1157 (11%)
Query: 116 PPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
P + + E++ D L K + +R ++ E L K+S+L +LQ + +
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ-- 233
+ +++++ +R A+ +E ++ + + L+EE D + + + + Q + L +Q
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 234 -----RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
R + V + +LE + V + N S ++E+ S T L +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEE 1019
Query: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
++ +NL K K + + SE E ++ ++ QELEK+K + + Q+
Sbjct: 1020 EKAKNLTKL--------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-- 406
D + I +L+ M +A+ + ++ L ++EIAQ + +K++ + + +E
Sbjct: 1072 ADLQAQIAELK----MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
SERAA + EK + EA LK E+++ T++ T + QQEL +++
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEA---LKTELED---TLDST------ATQQELRAKREQE 1175
Query: 467 VDVMKKSSEEQI----AKLQKLHEKELARKEQELTKKLQ--TREREFQEQMKVALEKSQS 520
V V+KK+ +E+ A++Q++ +K A+ +ELT++L+ R + ++ K LEK +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 521 ----EYLKISQEKEQQE----SLALEELELQKKA-----ILTESENKLRDLQQEAETYRT 567
E + Q K++ E L + ELQ K E +K+ LQ E E+
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 568 RILELESSLEKSLQENKNQSKDL--AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
+ E E K ++ + S L L E+ + ++ + + + E SL+ Q D
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD- 1353
Query: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
E+++ KQ + + L + K+ L F + +E + E Q E
Sbjct: 1354 ---EEMEA-KQNLERHISTLNIQLSDSKKKLQD-----FASTVEALEEGKKR----FQKE 1400
Query: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN--HHQQQVDSIIKEH 743
+E+L+ + E A KLE+ + L+ + D + +L+ + N Q++ D ++ E
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 744 EVSIQRTEKALKDQINQLELLLKERD-------KHLKEHQAHVENLEADIKRSEGELQQA 796
+ D+ ++ E +E++ + L+E E LE K + E++
Sbjct: 1461 ----KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
+ D + +A E Q+ +++ +L +LE E + E K + +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-------LQATEDAKLRLEVNM 1569
Query: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
A K Q + +Q ++QN E ++++ YE++LED E++Q K+ +
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAAAAKKKL---- 1622
Query: 917 REGQKKEIEILTQK-LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK---K 972
EG K++E+ + +E++I L + + + K+ ++++E + E+ T K K
Sbjct: 1623 -EGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 973 KLLDQEAKLKKELEN-TALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
K EA L + E+ A E ++K EK+ A+ L + + + D RLE +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQ----------EIHEIQLQEKEQEVAELK 1077
E L E + + +S +K QQAE+L + +E Q+ E++ EL+
Sbjct: 1741 LEEELEE--EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 1078 QKI-LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL 1136
K+ + G K + I L+ + + + +++++ ++K A SL Q + KLK L
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
L+V+ + + E + K AE+ +V +L +L+ +EE Q + ++ K
Sbjct: 1856 --LQVEDERKMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 1197 KSLEDKSLEFKKLSEEL 1213
+ L++ + + + E+
Sbjct: 1905 RELDEATESNEAMGREV 1921
Score = 182 bits (462), Expect = 3e-45
Identities = 211/938 (22%), Positives = 423/938 (45%), Gaps = 112/938 (11%)
Query: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Q+ + EE Q+ + ++ EN++K ++ L EK LQ++ + + +E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 1337 KESCITQL---KKELSENINAVTLMKEELKEK----KVEISSLSKQLTDLNVQLQNSISL 1389
E +L K+EL E ++ + EE +++ + E +++Q+ DL QL+
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 960
Query: 1390 SEKEAAISSLR--KQYDEEKCELL-DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
E+EAA L+ K E K + L D++ + + + LSKE+ E++ D + +E +
Sbjct: 961 -EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 1447 KKAQSRF---TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
+KA++ +H++ + EL+++L+ + K E ++ L+ + +++ L+ ++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKEL 1562
+ K ++ KKE L+ A + L+D I QK ++ + E+ + + Q+D++ +
Sbjct: 1080 ELKMQLAKKEEELQ-------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 1563 VQKLQHFQ--ELGEEKDNRVKEAEEKI-LTLENQVYSMKAELETK--KKELEHVNLSVKS 1617
+ Q +LGEE + E E+ + T Q K E E KK L+ S ++
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 1618 KEEELKALEDRLESESAAKLAELKR------------KAEQKIAAIKKQLLSQMEEKEEQ 1665
+ +E++ + E +L + KR + E A + ++L Q +++ E
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1666 YKKGTESHLSELNTKLQERER-------EVHILEEKLKSVESSQSETL-IVPRSAKNVAA 1717
KK E+ + EL +K + ER +VH L+ +++SV +E + AK+VA+
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1718 YTEQEEADSQGCVQKTYEEKISVLQ--RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
+ Q + D+Q +Q+ +K++V R L E+ LQ + +E + + +
Sbjct: 1313 LSSQLQ-DTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHIST 1368
Query: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN-LENV 1834
I+L ++ K + S + L+E + K+ + Q+ EK + ++ +N L+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
DD+ L + LE+K ++ D L +K + +SKY + + + R
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--------SSKYADERDRAEAEARE 1480
Query: 1895 KPTELL------EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
K T+ L EE E K + L + ME DL K +GK +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEME----DLV-------SSKDDVGKNVHE 1529
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+K R L + ++E +K + ++ +E Q ED +L+ ++ L +F L +
Sbjct: 1530 LEKSKRAL----ETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAR 2066
+++ E ++ + E E EL E + L A+K + DLK + + + R
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETEL---EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 2067 EE------EMTAKVRDLQTQLEELQKK----YQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
EE ++ A+++D Q +LE+ + + E E+ + +M+LQ LA
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 2117 TLISDSKLKEQEFREQI-------HNLEDRLKKYEKNV 2147
+ L+++E E++ + L+D ++ E +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Score = 157 bits (398), Expect = 8e-38
Identities = 222/1052 (21%), Positives = 459/1052 (43%), Gaps = 129/1052 (12%)
Query: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+++ ++ EE+ + QQ A + +M + EQL+E R Q
Sbjct: 926 EMEARLEEEEDRGQQLQAERK---------KMAQQMLDLEEQLEEEEAAR---------Q 967
Query: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD---- 119
KLQL + E+ + E L L + DL ++ A + +
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 120 MDSEAEDLVGNSD-SLNKEQLI-QRLRRMERSLSSYRGKYSELVTAYQ--------MLQR 169
+ ++ E ++ + L KE+ Q L +++R L + E + Q L +
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 170 EKKKLQGILSQSQDKSLRR-------------IAELREELQMDQQA-------KKHLQEE 209
++++LQ L++ D+ ++ I++L+E+L ++ A K+ L EE
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 210 FDASLEEKDQYISVLQTQ----------VSLLKQRL----RNGPMNVDVLKP-----LPQ 250
+A E + + TQ V++LK+ L R+ V ++ + +
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 251 LEPQAEVFTKEE-NPESDGEPVVEDGTSVK-TLETLQQRVKRQENLLKRCKETIQSHKEQ 308
L Q E F + + N + + + + ++ + L L Q + E+ K+ + +Q + +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
C+ + L +++ + E+E + + + K I +D +L QL+ + ++ E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER------AAFEELEKALST 422
T+++++ + +++ QL + Q +E E K+ ER + +K L
Sbjct: 1328 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIA 479
T EA + K ++I+ + + EE+ + L++ +R++QE+ D++ ++
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-- 1440
Query: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALE 538
+L EK+ + +Q L ++ + E+ + E + E +S + +E+L A E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESS---LEKSLQENKNQSKDLAVHLE 595
ELE K + E E DL + + ELE S LE ++E K Q ++L L+
Sbjct: 1501 ELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 596 A-EKNKHNKEITVMVEKHKTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREK----- 648
A E K E+ + K + E + + +Q+ +LQ +Y+TE+E R++
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 649 -CEQEKETLLKDKEIIFQAHIEEMNE--KTLEKLDVK----QTELESLSSELSEVLKARH 701
+++ E LKD E+ + I+ E K L KL + Q ELE + E+
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
+ E++ L+ +++++L A +K ++ + + E S AL+D+ +L
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE--LAEELASSLSGRNALQDEKRRL 1734
Query: 762 ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
E + + ++ L+E Q ++E + ++++ + +Q S +L +S + E Q
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--LEKQ--NSEM 877
+L+ KL ++E V+++ K L+A Q+++ ++Q EKQ +
Sbjct: 1795 KELRSKLHEME----------GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
+QK K L ++ ++ED K EQ K+ EK N ++ + Q +E E +Q+++A
Sbjct: 1845 KQKDKKLKEIL-LQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969
+ +E + +++ +K K + ET
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRRGNET 1934
Score = 122 bits (305), Expect = 5e-27
Identities = 145/628 (23%), Positives = 293/628 (46%), Gaps = 97/628 (15%)
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+L+ Q+++++ KE +LQ +E ++ +N +KE E+K L + ++ +L+ + +
Sbjct: 844 LLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 1607 ---ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
E E + + + +K++EL+ + +E A+L E + + +Q + A +K++ QM + E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEME----ARLEEEEDRGQQ-LQAERKKMAQQMLDLE 956
Query: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
EQ L E Q+ + E E K+K +E E L++ ++
Sbjct: 957 EQ--------LEEEEAARQKLQLEKVTAEAKIKKLED---EILVM------------DDQ 993
Query: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQYQERLI--- 1778
+ +K EE+IS L NL E+E+ + + + K E++ S E+R + +E+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 1779 -----KLEHAEAKQHED----QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK- 1828
KLE + HE Q+ I L+ +L +K ++ +A+ ++ KNN K
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1113
Query: 1829 QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888
+ LE D+Q+ L + E++ ++L L E + E+E+ Q L+
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL----EALKTELEDTLDSTATQQELR 1169
Query: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL------EFKLAGA--EREKQ 1940
R + +L++ +E+++SH Q + + AQ + +FK A A ++ KQ
Sbjct: 1170 AK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
L KE L +LR+L + +QE+E KK K++ + ++L+ K + +
Sbjct: 1228 TLEKENADLAGELRVLGQA-KQEVEHKKK--------KLEAQVQELQSKCSDGERA---- 1274
Query: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
+L K +L+ ++ E E + ++ L K +A L+ T + +
Sbjct: 1275 -RAELNDKVHKLQNEVESVTGMLNEAEGKAIK--------LAKDVASLSSQLQDTQELLQ 1325
Query: 2061 EILDAREE-EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
E + R++ ++ K+R L+ + LQ + +++E ++N L+ ++ +
Sbjct: 1326 E--ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------LERHISTLNIQL 1373
Query: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
SDSK K Q+F + LE+ K+++K +
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEI 1401
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 224 bits (570), Expect = 1e-57
Identities = 316/1326 (23%), Positives = 584/1326 (44%), Gaps = 240/1326 (18%)
Query: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS---QEKEQQESLALEEL 540
L K A+++Q+LT ++ +R +K+ + + K+ Q Q+E + +E
Sbjct: 808 LARKAFAKRQQQLTA-MKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKED 866
Query: 541 ELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
ELQK K ++EN+L++L+Q+ +++ E ++ L++ LQ + ++ EAE
Sbjct: 867 ELQKTKERQQKAENELKELEQK----HSQLTEEKNLLQEQLQA------ETELYAEAE-- 914
Query: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
E+ V + K ELE + H+ +A E+ + QQ Q E +K+ ++ +E L
Sbjct: 915 ----EMRVRLAAKKQELEEILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQL--- 966
Query: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719
E E +KL +++ E+ KLE+E+ V+ DQ +K+ +
Sbjct: 967 ----------EEEEAARQKLQLEKVTAEAKIK----------KLEDEILVMDDQNNKLSK 1006
Query: 720 ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK------ 773
E K L+++I+ L L E ++ K
Sbjct: 1007 E------------------------------RKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 774 -EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
+H++ + LE +K+ E Q+ + S HEQ + Q+A+L+ +L E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 833 TE--------------RILLTKQVAEVEAQKKDVCTELDAHKI-------QVQDLMQQLE 871
E + K++ E+E D+ +LD+ + Q +DL ++LE
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQT--KQILVEK----ENMILQMREGQKKEIE 925
+E+E + S E + +EQE T K+ L E+ E + +MR+ + +E
Sbjct: 1157 ALKTELEDTLDSTATQQELR---AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 926 ILTQKLSAKEDSIHILNEEYETKFK-NQEKKME-KVKQKAKEMQETLKKKLLDQEAKLKK 983
LT++L + + L++ +T K N + E +V +AK+ E KKKL Q +L+
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 984 EL---ENTALELS------QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
+ E EL+ Q E + ML A+ + ++ V+ L + ++ E L E
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
R++LN +S ++L ++ LQ+ QL E+ + L++ I + + K++
Sbjct: 1334 ETRQKLN--VSTKLRQLEEERNSLQD----QLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 1095 ------TWLKEEGVKQ-DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
EEG K+ + L +Q ++K+A + L + + +L+ L+ L VDL+
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-- 1445
Query: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Q QLV E+ +RK +L ++ K ++ + E + E K+L
Sbjct: 1446 ------QRQLVS---NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
+ EE A++ ++T +L+A+ +L+ SSK + + H K K A
Sbjct: 1497 RALEE-ALEAKEELERTNKMLKAEMEDLV---SSKDD-----VGKNVHELEKSKRA---- 1543
Query: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327
LE Q+ EE T QLEE E+++++ + L +AL+ +
Sbjct: 1544 ------LETQM----EEMKT----------QLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1328 GNQQQAASEK-ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL-NVQLQN 1385
QA E+ E QL+++L E T +++E K++ + ++ K DL +++LQ
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHE---YETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Query: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
++ +E AI LRK L ++ +E A D+ E
Sbjct: 1641 DSAIKGREEAIKQLRK---------------LQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
+KKA+S +Q+Q +L + E K Q +L KEEL ++ + ++D+
Sbjct: 1686 EKKAKSL------EADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNALQDE 1737
Query: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL----------KNYNQQK 1555
K ++E + + LE EL+ + + + D + + T + E L+ L ++ QQ
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 1556 DIEHKELVQKLQHFQELGEEKDNRVK-EAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
+ ++KEL KL E + VK + + I LE ++ ++ ++E + +E + S
Sbjct: 1798 ERQNKELRSKL-------HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ------YKK 1668
+K K+++LK E L+ E K+AE ++ +K A KQL Q+EE EE+ ++
Sbjct: 1851 LKQKDKKLK--EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1669 GTESHLSELNTKLQEREREVHILEEKLKS------VESSQSETLIVPRSAKNVAAYTEQE 1722
+ L E + REV+ L+ KL+ V S +S V +A T+
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTR 1968
Query: 1723 EADSQG 1728
+AD G
Sbjct: 1969 DADFNG 1974
Score = 209 bits (531), Expect = 3e-53
Identities = 273/1225 (22%), Positives = 538/1225 (43%), Gaps = 172/1225 (14%)
Query: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
K + + Q+ + ++M + +EL++ KE+ ++A E E +Q TEE + L E +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--KNLLQEQLQ 904
Query: 440 QIKTIEKTSEEERISL---QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496
+ +EE R+ L +QEL +E++ M+ EE+ + Q+L + +Q L
Sbjct: 905 AETELYAEAEEMRVRLAAKKQEL----EEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 497 TKKLQTREREFQEQMKVALEK--SQSEYLKISQE---------KEQQESLALEELELQKK 545
+ Q E E Q K+ LEK ++++ K+ E K +E LEE
Sbjct: 961 DLEEQLEEEEAARQ-KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605
L E E K ++L + + + I ELE L+K ++++ + + L LE + + +++I
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 606 TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
+ + ++ LK Q L +++ Q + +L ++ Q+ L K +E+ +
Sbjct: 1079 ADL----QAQIAELKMQ--------LAKKEEELQAALARLDDEIAQKNNALKKIREL--E 1124
Query: 666 AHIEEM-----------NEKTLEKLDVKQTELESLSSELSEVL-------KARHKLEEEL 707
HI ++ N+ +K D+ + ELE+L +EL + L + R K E+E+
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGE-ELEALKTELEDTLDSTATQQELRAKREQEV 1183
Query: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
+VLK D+ + EA++ E + H Q V+ + ++ E +R + L LE +
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENAD 1242
Query: 768 RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
L+ + +E K+ E ++Q+ +K + ++ +++ + ++ +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
L + E + I L K VA + +Q +D Q+L+Q+ +Q + K++ L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQD-----------TQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKK------EIEILTQKLSAKEDSIHIL 941
S + ++E E + + + +Q+ + +KK +E L + + I L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
++YE K + K+EK K + ++ + L LD + +L LE +K+++F+
Sbjct: 1412 TQQYEEKAAAYD-KLEKTKNRLQQELDDLVVD-LDNQRQLVSNLE-------KKQRKFDQ 1462
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ E +S +D R E +E+ E K A L+E
Sbjct: 1463 LLAEEKNISSK-YADERDRAEAEAREK-------------------ETKALSLARALEEA 1502
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
E + +E E+ LK ++ K+++ K + L++ +T + E++ QL++
Sbjct: 1503 LEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1122 VNSLAQDETKLKAHLEKLEVDLNKSL--------KENTFLQEQLVELKMLAEEDKRK--- 1170
+ + + +L+ +++ L+ + L ++ LQ QL E + E+++++
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 1171 ----VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
+L LK + + S E++ K L + K EL D + E
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE---DARASRDEI 1678
Query: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKV----KEALLIKTCTVSELEAQL---R 1279
AK NE K ++ + + Q K+A L K EL + L
Sbjct: 1679 FATAKENE------KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
L +E+ L Q +LEE++ +++M + + E L E ++ A + ES
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792
Query: 1340 CITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
QL+++ E + + M+ +K K K I++L ++ L Q++ EK+AA S
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKS 1850
Query: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
L KQ D++ E+L QV+D + K+ + ++ E +K +R
Sbjct: 1851 L-KQKDKKLKEILLQVED---------ERKM---------AEQYKEQAEKGNAR------ 1885
Query: 1459 TVKELQIQLELKSKEAYEKDEQINL----LKEELDQQNKRFDCLKGEMEDDKSKMEK-KE 1513
VK+L+ QLE EA E+ ++IN L+ ELD+ + + + E+ KSK+ + E
Sbjct: 1886 -VKQLKRQLE----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Query: 1514 SNLETELKSQTARIMELEDHITQKT 1538
++ +S R++E D ++T
Sbjct: 1941 TSFVPSRRSGGRRVIENADGSEEET 1965
Score = 188 bits (477), Expect = 6e-47
Identities = 270/1194 (22%), Positives = 528/1194 (44%), Gaps = 158/1194 (13%)
Query: 960 KQKAKEMQETLKKKLLDQEAKLKKELEN-----------TALELSQKEKQFNAKMLEMAQ 1008
K AK Q+ K++ + +L N L+++++E++ AK
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------ 864
Query: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRR--ELNDVISIWEKKLNQQAEELQEIHE--I 1064
D + + + Q++ L E+ ++ +L + ++ +++L + E E E +
Sbjct: 865 ------EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
+L K+QE+ E+ ++ E+E+ ++ L+ E K + +L+EQL+++ A
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 1125 LAQDETKLKAHLEKLEVDL-------NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
L ++ +A ++KLE ++ NK KE L+E++ +L E++ K LT K
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT-K 1034
Query: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
LK E S+ S E K E E +KL +L ++ A L+A+ EL
Sbjct: 1035 LKNKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQIAELKM 1090
Query: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
+ K + + ++ + AL + ELE + L E+ ++ + +A
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKA-- 1144
Query: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
E Q + + ++E+L TE E QQ+ +++E +T LKK L E +
Sbjct: 1145 -----EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1358 MKEELKEKKVE-ISSLSKQLTDLN---VQLQNSISLSEKEAA--------ISSLRKQYDE 1405
+E+++K + + L++QL L + EKE A + +++ +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1406 EKCELLDQVQDLSFKVDTLSK------EKISALE-QVDDWSNKFSEWKKKAQSRFTQHQN 1458
+K +L QVQ+L K + +K+ L+ +V+ + +E + KA +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
+LQ EL +E +K L++ +++N D L EME K +E+ S L
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-KQNLERHISTLNI 1378
Query: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH--KELVQKLQHFQELGEEK 1576
+L ++ + +E+L E K + QK+IE+ ++ +K + +L + K
Sbjct: 1379 QLSDSKKKLQDFAS-------TVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHV-----NLSVKSKEE----ELKALED 1627
+ +E ++ ++ L+NQ + + LE K+++ + + N+S K +E E +A E
Sbjct: 1430 NRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSE--LNTKL 1681
++ S A+ E +A++++ K L ++ME+ K++ K E S+ L T++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
+E + ++ LE++L++ E ++ R N+ A Q E D Q ++ EEK L
Sbjct: 1549 EEMKTQLEELEDELQATEDAKL------RLEVNMQALKGQFERDLQARDEQN-EEKRRQL 1601
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
QR L E E L+ + K+ +++ + + + + ++L+ D ++ G
Sbjct: 1602 QRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGR----- 1647
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EE K+ + AQ + + + +A + D++ T +E E + LE + +L
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASR------DEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 1862 CLV------RQKEVHRVEM-EELTSKYEKLQALQQMDGRNKPT-ELLEENTEEKSKSHLV 1913
L +Q ++ + E+ EEL S ALQ R + LEE EE+
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ----- 1756
Query: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
NMEA + + AE+ +L E QK+ + +Q+LE KE
Sbjct: 1757 -----GNMEAMSDRVRKATQQAEQLSNELATERSTAQKN-----ESARQQLERQNKEL-- 1804
Query: 1974 EREEKIKQEQEDLELKHNSTLKQL---MREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
K+ + + ++ K ST+ L + + Q+ Q+ +E + K K ++++ L
Sbjct: 1805 --RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 2031 LESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
L+ E + + K+ AEK + + KR E + + + A R LQ +L+E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 186 bits (472), Expect = 2e-46
Identities = 256/1157 (22%), Positives = 514/1157 (44%), Gaps = 137/1157 (11%)
Query: 116 PPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ 175
P + + E++ D L K + +R ++ E L K+S+L +LQ + +
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 176 GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ-- 233
+ +++++ +R A+ +E ++ + + L+EE D + + + + Q + L +Q
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 234 -----RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
R + V + +LE + V + N S ++E+ S T L +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEE 1026
Query: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
++ +NL K K + + SE E ++ ++ QELEK+K + + Q+
Sbjct: 1027 EKAKNLTKL--------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-- 406
D + I +L+ M +A+ + ++ L ++EIAQ + +K++ + + +E
Sbjct: 1079 ADLQAQIAELK----MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
SERAA + EK + EA LK E+++ T++ T + QQEL +++
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEA---LKTELED---TLDST------ATQQELRAKREQE 1182
Query: 467 VDVMKKSSEEQI----AKLQKLHEKELARKEQELTKKLQ--TREREFQEQMKVALEKSQS 520
V V+KK+ +E+ A++Q++ +K A+ +ELT++L+ R + ++ K LEK +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 521 ----EYLKISQEKEQQE----SLALEELELQKKA-----ILTESENKLRDLQQEAETYRT 567
E + Q K++ E L + ELQ K E +K+ LQ E E+
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 568 RILELESSLEKSLQENKNQSKDL--AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
+ E E K ++ + S L L E+ + ++ + + + E SL+ Q D
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD- 1360
Query: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
E+++ KQ + + L + K+ L F + +E + E Q E
Sbjct: 1361 ---EEMEA-KQNLERHISTLNIQLSDSKKKLQD-----FASTVEALEEGKKR----FQKE 1407
Query: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN--HHQQQVDSIIKEH 743
+E+L+ + E A KLE+ + L+ + D + +L+ + N Q++ D ++ E
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 744 EVSIQRTEKALKDQINQLELLLKERD-------KHLKEHQAHVENLEADIKRSEGELQQA 796
+ D+ ++ E +E++ + L+E E LE K + E++
Sbjct: 1468 ----KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
+ D + +A E Q+ +++ +L +LE E + E K + +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-------LQATEDAKLRLEVNM 1576
Query: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
A K Q + +Q ++QN E ++++ YE++LED E++Q K+ +
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---ERKQRALAAAAKKKL---- 1629
Query: 917 REGQKKEIEILTQK-LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK---K 972
EG K++E+ + +E++I L + + + K+ ++++E + E+ T K K
Sbjct: 1630 -EGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 973 KLLDQEAKLKKELEN-TALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
K EA L + E+ A E ++K EK+ A+ L + + + D RLE +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQ----------EIHEIQLQEKEQEVAELK 1077
E L E + + +S +K QQAE+L + +E Q+ E++ EL+
Sbjct: 1748 LEEELEE--EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 1078 QKI-LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL 1136
K+ + G K + I L+ + + + +++++ ++K A SL Q + KLK L
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
L+V+ + + E + K AE+ +V +L +L+ +EE Q + ++ K
Sbjct: 1863 --LQVEDERKMAE---------QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
Query: 1197 KSLEDKSLEFKKLSEEL 1213
+ L++ + + + E+
Sbjct: 1912 RELDEATESNEAMGREV 1928
Score = 182 bits (462), Expect = 3e-45
Identities = 211/938 (22%), Positives = 423/938 (45%), Gaps = 112/938 (11%)
Query: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Q+ + EE Q+ + ++ EN++K ++ L EK LQ++ + + +E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 1337 KESCITQL---KKELSENINAVTLMKEELKEK----KVEISSLSKQLTDLNVQLQNSISL 1389
E +L K+EL E ++ + EE +++ + E +++Q+ DL QL+
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 1390 SEKEAAISSLR--KQYDEEKCELL-DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
E+EAA L+ K E K + L D++ + + + LSKE+ E++ D + +E +
Sbjct: 968 -EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 1447 KKAQSRF---TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
+KA++ +H++ + EL+++L+ + K E ++ L+ + +++ L+ ++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKEL 1562
+ K ++ KKE L+ A + L+D I QK ++ + E+ + + Q+D++ +
Sbjct: 1087 ELKMQLAKKEEELQ-------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1563 VQKLQHFQ--ELGEEKDNRVKEAEEKI-LTLENQVYSMKAELETK--KKELEHVNLSVKS 1617
+ Q +LGEE + E E+ + T Q K E E KK L+ S ++
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1618 KEEELKALEDRLESESAAKLAELKR------------KAEQKIAAIKKQLLSQMEEKEEQ 1665
+ +E++ + E +L + KR + E A + ++L Q +++ E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1666 YKKGTESHLSELNTKLQERER-------EVHILEEKLKSVESSQSETL-IVPRSAKNVAA 1717
KK E+ + EL +K + ER +VH L+ +++SV +E + AK+VA+
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1718 YTEQEEADSQGCVQKTYEEKISVLQ--RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775
+ Q + D+Q +Q+ +K++V R L E+ LQ + +E + + +
Sbjct: 1320 LSSQLQ-DTQELLQEETRQKLNVSTKLRQLEEERNSLQ---DQLDEEMEAKQNLERHIST 1375
Query: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN-LENV 1834
I+L ++ K + S + L+E + K+ + Q+ EK + ++ +N L+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894
DD+ L + LE+K ++ D L +K + +SKY + + + R
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--------SSKYADERDRAEAEARE 1487
Query: 1895 KPTELL------EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
K T+ L EE E K + L + ME DL K +GK +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEME----DLV-------SSKDDVGKNVHE 1536
Query: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
L+K R L + ++E +K + ++ +E Q ED +L+ ++ L +F L +
Sbjct: 1537 LEKSKRAL----ETQMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAR 2066
+++ E ++ + E E EL E + L A+K + DLK + + + R
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETEL---EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 2067 EE------EMTAKVRDLQTQLEELQKK----YQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
EE ++ A+++D Q +LE+ + + E E+ + +M+LQ LA
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 2117 TLISDSKLKEQEFREQI-------HNLEDRLKKYEKNV 2147
+ L+++E E++ + L+D ++ E +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Score = 157 bits (398), Expect = 8e-38
Identities = 222/1052 (21%), Positives = 459/1052 (43%), Gaps = 129/1052 (12%)
Query: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
+++ ++ EE+ + QQ A + +M + EQL+E R Q
Sbjct: 933 EMEARLEEEEDRGQQLQAERK---------KMAQQMLDLEEQLEEEEAAR---------Q 974
Query: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD---- 119
KLQL + E+ + E L L + DL ++ A + +
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 120 MDSEAEDLVGNSD-SLNKEQLI-QRLRRMERSLSSYRGKYSELVTAYQ--------MLQR 169
+ ++ E ++ + L KE+ Q L +++R L + E + Q L +
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 170 EKKKLQGILSQSQDKSLRR-------------IAELREELQMDQQA-------KKHLQEE 209
++++LQ L++ D+ ++ I++L+E+L ++ A K+ L EE
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 210 FDASLEEKDQYISVLQTQ----------VSLLKQRL----RNGPMNVDVLKP-----LPQ 250
+A E + + TQ V++LK+ L R+ V ++ + +
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 251 LEPQAEVFTKEE-NPESDGEPVVEDGTSVK-TLETLQQRVKRQENLLKRCKETIQSHKEQ 308
L Q E F + + N + + + + ++ + L L Q + E+ K+ + +Q + +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
C+ + L +++ + E+E + + + K I +D +L QL+ + ++ E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER------AAFEELEKALST 422
T+++++ + +++ QL + Q +E E K+ ER + +K L
Sbjct: 1335 TRQKLNVSTKLR-----QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIA 479
T EA + K ++I+ + + EE+ + L++ +R++QE+ D++ ++
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-- 1447
Query: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL-ALE 538
+L EK+ + +Q L ++ + E+ + E + E +S + +E+L A E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESS---LEKSLQENKNQSKDLAVHLE 595
ELE K + E E DL + + ELE S LE ++E K Q ++L L+
Sbjct: 1508 ELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 596 A-EKNKHNKEITVMVEKHKTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREK----- 648
A E K E+ + K + E + + +Q+ +LQ +Y+TE+E R++
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 649 -CEQEKETLLKDKEIIFQAHIEEMNE--KTLEKLDVK----QTELESLSSELSEVLKARH 701
+++ E LKD E+ + I+ E K L KL + Q ELE + E+
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
+ E++ L+ +++++L A +K ++ + + E S AL+D+ +L
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE--LAEELASSLSGRNALQDEKRRL 1741
Query: 762 ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
E + + ++ L+E Q ++E + ++++ + +Q S +L +S + E Q
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--LEKQ--NSEM 877
+L+ KL ++E V+++ K L+A Q+++ ++Q EKQ +
Sbjct: 1802 KELRSKLHEME----------GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
+QK K L ++ ++ED K EQ K+ EK N ++ + Q +E E +Q+++A
Sbjct: 1852 KQKDKKLKEIL-LQVEDERKMAEQYKE-QAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969
+ +E + +++ +K K + ET
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLRRGNET 1941
Score = 122 bits (305), Expect = 5e-27
Identities = 145/628 (23%), Positives = 293/628 (46%), Gaps = 97/628 (15%)
Query: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
+L+ Q+++++ KE +LQ +E ++ +N +KE E+K L + ++ +L+ + +
Sbjct: 851 LLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 1607 ---ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
E E + + + +K++EL+ + +E A+L E + + +Q + A +K++ QM + E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEME----ARLEEEEDRGQQ-LQAERKKMAQQMLDLE 963
Query: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
EQ L E Q+ + E E K+K +E E L++ ++
Sbjct: 964 EQ--------LEEEEAARQKLQLEKVTAEAKIKKLED---EILVM------------DDQ 1000
Query: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQYQERLI--- 1778
+ +K EE+IS L NL E+E+ + + + K E++ S E+R + +E+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 1779 -----KLEHAEAKQHED----QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK- 1828
KLE + HE Q+ I L+ +L +K ++ +A+ ++ KNN K
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1120
Query: 1829 QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888
+ LE D+Q+ L + E++ ++L L E + E+E+ Q L+
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL----EALKTELEDTLDSTATQQELR 1176
Query: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL------EFKLAGA--EREKQ 1940
R + +L++ +E+++SH Q + + AQ + +FK A A ++ KQ
Sbjct: 1177 AK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
L KE L +LR+L + +QE+E KK K++ + ++L+ K + +
Sbjct: 1235 TLEKENADLAGELRVLGQA-KQEVEHKKK--------KLEAQVQELQSKCSDGERA---- 1281
Query: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
+L K +L+ ++ E E + ++ L K +A L+ T + +
Sbjct: 1282 -RAELNDKVHKLQNEVESVTGMLNEAEGKAIK--------LAKDVASLSSQLQDTQELLQ 1332
Query: 2061 EILDAREE-EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
E + R++ ++ K+R L+ + LQ + +++E ++N L+ ++ +
Sbjct: 1333 E--ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------LERHISTLNIQL 1380
Query: 2120 SDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
SDSK K Q+F + LE+ K+++K +
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEI 1408
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 215 bits (547), Expect = 4e-55
Identities = 409/1896 (21%), Positives = 805/1896 (42%), Gaps = 317/1896 (16%)
Query: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Q+ + K M +G E E + R +E+E + + E +KL +++E+ + E
Sbjct: 29 QISNFTKDMLMEGTEEVEAELPDSRT--KEIEAIHAILRSENERLKKLCTDLEEKHEASE 86
Query: 446 KTSEEERISLQQELSRVKQEVVDVMKK--SSEEQIAKLQKLHEK---------------- 487
+++ S + +L + + E+ + + + ++Q+ KLQ +
Sbjct: 87 IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSF 146
Query: 488 -------------------ELARKEQE---LTKKLQTREREFQEQMKVAL--------EK 517
++ +QE L+ ++ E E +A
Sbjct: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
Query: 518 SQSEYLK---ISQEKEQQESLALEELELQKKAILTESENKLRDL----QQEAETYRTRIL 570
QSE K I +E +Q S +++ + + + + KL ++ ++E Y RI
Sbjct: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
Query: 571 ELESSL--------EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK---TELESL 619
ELE+ L E L + K + V L+ EK + K++ + +K K +L S
Sbjct: 267 ELENLLQQGGSGVIETDLSKIYEMQKTIQV-LQIEKVESTKKMEQLEDKIKDINKKLSSA 325
Query: 620 KHQQDAL--WTEKLQVLKQQYQTEMEKLREKCE-------QEKETLLKDKEIIFQAHIEE 670
++ +D L E+L V K+Q E E L+ +C ++ +T+ + + I+ Q+ E
Sbjct: 326 ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385
Query: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
+ + L + E+ LSS L + L E+ LK + + +++E ++ + ++K
Sbjct: 386 EVFRLQQALSDAENEIMRLSS-----LNQDNSLAEDNLKLKMRIEVLEKE-KSLLSQEKE 439
Query: 731 HHQQQVDSIIKEHEV--SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Q + + E+EV S + +L +++ L L L+ +++ L + + E L A+I+
Sbjct: 440 ELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE 499
Query: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
+ + Q+A+ + + + S + + +L Q DL E+ K+V ++E
Sbjct: 500 LDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ------DLNDEK----KRVHQLEDD 549
Query: 849 KKDVCTELDAHK---IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905
K D+ ELD K IQ + + L ++E KV++L ++ NK QE +
Sbjct: 550 KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL-------VDQLNKSQE--SNV 600
Query: 906 LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN-----QEKKMEKVK 960
++KEN L+++E ++ E L++ + + + LN++ + FK+ +E ++ +K
Sbjct: 601 SIQKEN--LELKEHIRQNEEELSR---IRNELMQSLNQDSNSNFKDTLLKEREAEVRNLK 655
Query: 961 QKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Q E++ E LKK D ++EN L L+ ++ + ++ E N+ +
Sbjct: 656 QNLSELEQLNENLKKVAFD------VKMENEKLVLACEDVRH--QLEECLAGNNQLSLEK 707
Query: 1018 VSRLETNQKEQIESLTEV--HRRELNDVISIWEK---------KLNQQAEELQEIHEIQL 1066
+ +ET + E+ E E+ ++ L + + +EK LN A +L+ H I+L
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 1067 -QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125
Q+K+ E+AELK+ I + +E ++ EE +L + + +K + L
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE-------QKQLTQLINKKEIFIEKL 820
Query: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
+ +KL+ L+K +++L++N L++ T +E+
Sbjct: 821 KERSSKLQEELDK----YSQALRKNEILRQ------------------------TIEEKD 852
Query: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
+SL S E++N E E ++L EE + +T + + KT + + +S+ +
Sbjct: 853 RSLGSMKEENNHLQE----ELERLREEQS--------RTAPVADPKTLDSVTELASEVSQ 900
Query: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQ--ATHQ--LEE 1301
+ + H + ++ + + + +L L++ +E + +Q ATH E
Sbjct: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
Query: 1302 KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE 1361
K+ +IKS++ IE + T+ ++Q S I Q K S NI
Sbjct: 961 KDEEIKSLQKTIEQIKTQLH-------EERQDIQTDNSDIFQETKVQSLNI--------- 1004
Query: 1362 LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV 1421
E E LSK T+ V+ + E+E I K +E+ L Q +
Sbjct: 1005 --ENGSEKHDLSKAETERLVK-----GIKERELEI----KLLNEKNISLTKQ-------I 1046
Query: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
D LSK+++ L Q+ A+ T H V LQ QL+ + E E++
Sbjct: 1047 DQLSKDEVGKLTQIIQ-QKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER----EKV 1101
Query: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
+ E ++N +M D + E L+ E K + R + ++T I
Sbjct: 1102 FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--I 1159
Query: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHF----------QELGEEKDNRVKEAEEKILTLE 1591
++L+ +++ +KDIE L QK Q E G N+ +E ++ L+
Sbjct: 1160 QNLSRIIR----EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLK 1215
Query: 1592 NQVYSM---KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKI 1648
QV M K ++ T + ++H + ++ + +L+A + ++S++ +KL
Sbjct: 1216 QQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA-QVLVDSDNNSKL----------- 1263
Query: 1649 AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS-QSETLI 1707
+ L Q E+ E K L+++ + + +L KL + S +L+
Sbjct: 1264 -QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLL 1322
Query: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
P+SA+ + A + ++S +Q+ EE L+++L EK+ + R QE +S
Sbjct: 1323 TPQSAECLRASKSEVLSESSELLQQELEE----LRKSLQEKDATI-RTLQENNHRLSDSI 1377
Query: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
+ + + + +E KQ +++ + LQ+ L+EK+ LI A+ + N
Sbjct: 1378 AATSELERKEHEQTDSEIKQLKEKQDV--LQKLLKEKD---LLIKAKSDQLLSSNENFTN 1432
Query: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
K N + L+E+ L ILE I +L K + +E K + QAL
Sbjct: 1433 KVNENELLRQAVTNLKERIL---ILEMDIGKL-------KGENEKIVETYRGKETEYQAL 1482
Query: 1888 QQMDGRNKPTELLEENTEE----KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Q+ + K + +L E E K K+ + L + + +L L + ++K
Sbjct: 1483 QETN--MKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK-- 1538
Query: 1944 KEIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFN 2002
+ + ++D ML K+ Q E L+ E + R+++ + QE LE N L+
Sbjct: 1539 TVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE-LERLRNHLLESEDSYTR 1597
Query: 2003 TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE- 2061
LA +++E ++ K T+ + + V + + + ++Q ++ + L +K+ +E
Sbjct: 1598 EALAAEDREAKLRKKVTVLEEKLVSSS--NAMENASHQASVQVESLQEQLNVVSKQRDET 1655
Query: 2062 -----ILDAREEEMTAKVRDLQTQLE------------ELQKKYQQKLEQEENPGNDNVT 2104
+ + ++ + +LQ LE EL+K+ Q E ++N N
Sbjct: 1656 ALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGK 1715
Query: 2105 IMELQTQLAQ-KTTLISDSKLKEQ--EFREQIHNLE 2137
++ LQ L + L S S+L EQ EQI L+
Sbjct: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
Score = 214 bits (544), Expect = 1e-54
Identities = 330/1691 (19%), Positives = 738/1691 (43%), Gaps = 245/1691 (14%)
Query: 567 TRILELESSLEKSLQENKNQSKDL-AVH--LEAEKNKHNKEITVMVEKHKTELESLKHQQ 623
T+ + +E + E + +++K++ A+H L +E + K T + EKH+ +K QQ
Sbjct: 34 TKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIK-QQ 92
Query: 624 DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII-------------------- 663
+ +LQ Q + E+ L+ + ++ LLK +
Sbjct: 93 STSYRNQLQ----QKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAY 148
Query: 664 -FQAHIEEMNEKTLEKLDV--KQTELESLSSELS----EVLKARHKLEEELSVLKDQTDK 716
H ++ ++ D+ Q E+ LS+E+S EV RH + + D +D+
Sbjct: 149 GISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQ 208
Query: 717 MK--------QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
+ +EL+ ++ + HQ ++ + H+ + + +++++ E ++E
Sbjct: 209 SEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL 268
Query: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
+ L++ + V +E D+ + + + + V Q + + ++ + E+++ + +KL
Sbjct: 269 ENLLQQGGSGV--IETDLSK----IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKL 322
Query: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
E +R +L ++ ++ +K+ + E + K++ L KQ+ M +K + L Q
Sbjct: 323 SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQ-- 380
Query: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
+E + +Q L + EN I+++ L Q S ED++ + + +
Sbjct: 381 ----SASVEEVFRLQQALSDAENEIMRLSS--------LNQDNSLAEDNLKL-----KMR 423
Query: 949 FKNQEKKMEKVKQKAKEMQETLKK---------KLLDQEAKLKKELENTALELSQKEKQF 999
+ EK+ + Q+ +E+Q +L K ++ L EL + L L KE++
Sbjct: 424 IEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQEL 483
Query: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
N ++S ET E IE L ++ +I I ++ QQ E
Sbjct: 484 N---------------QSISEKETLIAE-IEELDRQNQEATKHMILIKDQLSKQQNEGDS 527
Query: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
I +++ Q++ + K+++ +K ++ KE+ KE+ ++ + LN+L
Sbjct: 528 IISKLK-----QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL-------- 574
Query: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK-- 1177
H+ + KL+ +E L LNKS + N +Q++ +ELK +++ ++S + ++
Sbjct: 575 -HLT-----KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Query: 1178 ---------------LKTTDEEFQSLK---SSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
LK + E ++LK S E+ N++L+ + + K +E+L + +
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
+ E L A N+L ++ + + K+ LL + ++ E +
Sbjct: 689 VRHQLEECL-AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE---ANKYEKTIE 744
Query: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMK-ADIESLVTEKEALQKEGGNQQQAASEKE 1338
+L+ +N LN S Q H+ K NQ K M+ A+++ + + + KE + ++ E++
Sbjct: 745 ELSNARN-LNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ 803
Query: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSI---SLSEKEA 1394
+TQL IN + E+LKE+ S L ++L + L +N I ++ EK+
Sbjct: 804 KQLTQL-------INKKEIFIEKLKERS---SKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
++ S++++ + + EL ++ S + + ++ ++ ++ + K+ +
Sbjct: 854 SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913
Query: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
HQ +++ + E+ ++++ + + +Q N L E +++ ++K
Sbjct: 914 HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Query: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
++T+L + I I Q+T +++SLN ++N +++ D+ E + ++ +
Sbjct: 974 QIKTQLHEERQDIQTDNSDIFQET-KVQSLN--IENGSEKHDLSKAETERLVKGI----K 1026
Query: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
E++ +K EK ++L Q+ + K E+ + ++ K+ E++AL R+ S S
Sbjct: 1027 ERELEIKLLNEKNISLTKQIDQL------SKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE--REREVHIL- 1691
+ ++ Q A ++++ + + EK + SHL K+ + +E ++
Sbjct: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-----NSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 1692 ---EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR----- 1743
E K S S + + +N++ +++ + QK + ++VLQ
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC-QTLLAVLQTSSTGN 1194
Query: 1744 -----NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
N + E+LLQ + K++ V E + Q + ++H A+ E+ + LQ
Sbjct: 1195 EAGGVNSNQFEELLQERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEE---LHQLQ 1250
Query: 1799 EEL---EEKNKK----YSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
++ + N K Y+ ++ + + E N Q L V + + K+L
Sbjct: 1251 AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF--GQELAQVQHSIGQLCNTKDLLLGK 1308
Query: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911
L+ +L S + LT + + + + ++ +ELL++ EE KS
Sbjct: 1309 LDIISPQLSSASL------------LTPQSAECLRASKSEVLSESSELLQQELEELRKSL 1356
Query: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
+ + ++ ++ L +A ++ KE + +++ L KE Q L+ L KE
Sbjct: 1357 QEKDATIRTLQENNHRLSDSIAATSELER---KEHEQTDSEIKQL-KEKQDVLQKLLKEK 1412
Query: 1972 D---QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE---------T 2019
D + + +++ E+ K N +L+R+ T L ++ LEM I +
Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNE--NELLRQAVTNLKERILILEMDIGKLKGENEKIVE 1470
Query: 2020 INKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT 2079
+ +E E + L+ + + +L++ + +K A +E++L +E+ T ++ L
Sbjct: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530
Query: 2080 QLEELQKK---YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD-SKLKEQEFR--EQI 2133
++ +Q+K +QQ+ +Q ++ L+ + + T L ++ +L+++EFR +++
Sbjct: 1531 AVKSMQEKTVVFQQERDQ---------VMLALKQKQMENTALQNEVQRLRDKEFRSNQEL 1581
Query: 2134 HNLEDRLKKYE 2144
L + L + E
Sbjct: 1582 ERLRNHLLESE 1592
Score = 206 bits (523), Expect = 3e-52
Identities = 383/1887 (20%), Positives = 799/1887 (42%), Gaps = 315/1887 (16%)
Query: 127 LVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 186
L G + K+ L++ +E L R K E + A +L+ E ++L+ + + ++K
Sbjct: 26 LTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHA--ILRSENERLKKLCTDLEEK-- 81
Query: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQT-QVSLLKQ--RLRNGPMNV- 242
E+Q+ QQ+ + + L++K+ IS L+ Q++L Q +L++ +V
Sbjct: 82 ----HEASEIQIKQQSTSYRNQ-----LQQKEVEISHLKARQIALQDQLLKLQSAAQSVP 132
Query: 243 ---------------------------------DVLKPLPQLEPQAEVFTKEENPESDGE 269
D++ ++ + ++ E+
Sbjct: 133 SGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWR 192
Query: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKET----IQSHKEQCTLL--------TSEKE 317
+ + + T + Q + + +N++K K+ I H+ + ++L T
Sbjct: 193 HIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISR 252
Query: 318 ALQEQL---DERLQELE-------------------------KIKDLHMAEKTKLITQL- 348
+E+L +ER++ELE ++ + E TK + QL
Sbjct: 253 RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE 312
Query: 349 ---RDAKNLIEQLEQDKGMVIAET------KRQMHETLEMKEEEIAQLR-SRIKQMTTQG 398
+D + E D+ ++ E KRQ+ E E + E ++L+ S +KQ T
Sbjct: 313 DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT 372
Query: 399 EELREQKEKSERAAFEELEKALSTA-----------QKTEEARRKLKAEMDEQIKTIEKT 447
E+ R + + L++ALS A Q A LK +M ++ EK+
Sbjct: 373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKS 432
Query: 448 -SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQELTKKLQTRE 504
+E+ LQ L ++ E +V+K ++ I+ +LH+ L KEQEL + + +E
Sbjct: 433 LLSQEKEELQMSLLKLNNE-YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKE 491
Query: 505 ---REFQEQMKVALEKSQSEYLKISQEKEQQE------SLALEELELQKKAILTESENKL 555
E +E + E ++ L Q +QQ S ++L +KK + ++K+
Sbjct: 492 TLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM 551
Query: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615
D+ +E + + ++++ E +L L K + +D +L + NK ++E V ++K E
Sbjct: 552 -DITKELDVQKEKLIQSEVAL-NDLHLTKQKLEDKVENLVDQLNK-SQESNVSIQKENLE 608
Query: 616 LESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ------AHIE 669
L+ Q + E+L ++ + + ++ K+TLLK++E + + +E
Sbjct: 609 LKEHIRQNE----EELSRIRNELMQSLN--QDSNSNFKDTLLKEREAEVRNLKQNLSELE 662
Query: 670 EMNEKTLEKL--DVKQTE------LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721
++NE L+K+ DVK E + +L E L ++L E + + + K E+
Sbjct: 663 QLNE-NLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Query: 722 EA-------KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
EA ++ E+ N +++ ++ + ++ AL+ + L L +++D + E
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLN----TSALQLEHEHLIKLNQKKDMEIAE 777
Query: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
+ ++E ++ D H++TK + Q++L L +
Sbjct: 778 LKKNIEQMDTD-------------------------HKETKDVLSSSLEEQKQLTQLINK 812
Query: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
+ + +++ E ++ ++ ELD + Q ++N + Q ++ + S E+
Sbjct: 813 KEIFIEKLKERSSKLQE---ELDKY--------SQALRKNEILRQTIEEKDRSLGSMKEE 861
Query: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
N QE+ +++ +E K ++ +T+ L+++ ++ + E E + K+ +K
Sbjct: 862 NNHLQEELERL---REEQSRTAPVADPKTLDSVTE-LASEVSQLNTIKEHLEEEIKHHQK 917
Query: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
+E Q ++ ++L+++ KKE++ E + +Q NA ++ I
Sbjct: 918 IIEDQNQSKMQLLQSLQEQ--------KKEMD----EFRYQHEQMNATHTQLFLEKDEEI 965
Query: 1015 SDAVSRLETNQKEQIESLTEVHRREL---NDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
+ EQI++ R+++ N I K + E E H++ E E+
Sbjct: 966 KSLQKTI-----EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
Query: 1072 EVAELKQK---ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV----NS 1124
V +K++ I L + + K+I L ++ V + T + + Q+ L+ ++ H S
Sbjct: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ-QKDLEIQALHARISSTS 1079
Query: 1125 LAQDETKLKAHL-------EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
QD L+ L EK+ LN+ +EN+ L+ + ++ + + + +L +
Sbjct: 1080 HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
Query: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL-----EAKT 1232
K F+S S + +++++ S ++ E I++D +K + LL +
Sbjct: 1140 NKKLSTRFES--SGQDMFRETIQNLS----RIIREKDIEIDALSQKCQTLLAVLQTSSTG 1193
Query: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF 1292
NE ++S++ +L + + K++E TV ++ + QL EE + L
Sbjct: 1194 NEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ--- 1250
Query: 1293 QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENI 1352
L + +N K ++ D L+ E + + N Q ++ + I QL
Sbjct: 1251 ---AQVLVDSDNNSK-LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL-------C 1299
Query: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
N L+ +L ++SS S L Q + S+ E +S + +E EL
Sbjct: 1300 NTKDLLLGKLDIISPQLSSASL----LTPQSAECLRASKSE-VLSESSELLQQELEELRK 1354
Query: 1413 QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSK 1472
+Q+ + TL + ++ D SE ++K Q + +K+L+ + ++ K
Sbjct: 1355 SLQEKDATIRTLQENN----HRLSDSIAATSELERKEHE---QTDSEIKQLKEKQDVLQK 1407
Query: 1473 EAYEKDEQINLLKEELDQQNKRFDCLKGEME---DDKSKMEKKESNLETELKSQTARIME 1529
EKD I ++L N+ F E E + ++++ LE ++ +
Sbjct: 1408 LLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEK 1467
Query: 1530 LEDHITQKTIEIESLNEVLKNYN---QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
+ + K E ++L E ++ ++K+ E + +K F++L +EK+ +
Sbjct: 1468 IVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQ 1527
Query: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
+L N V SM+ + ++E + V L++K K+ E AL++ ++ +L + + ++ Q
Sbjct: 1528 LL---NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQ-----RLRDKEFRSNQ 1579
Query: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
++ ++ LL E E+ Y T L+ + + + R ++V +LEEKL V SS +
Sbjct: 1580 ELERLRNHLL----ESEDSY---TREALAAEDREAKLR-KKVTVLEEKL--VSSSNAMEN 1629
Query: 1707 IVPRSAKNVAAYTEQ-----EEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761
+++ V + EQ ++ D +E++ +L + +L+ QE++
Sbjct: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKA 1689
Query: 1762 TVSSHFEMRCQYQERLIKLEHAEAKQHED--QSMIGHLQEELEEKN---KKYSLIVAQHV 1816
S+ E Q++LI AE K++ + + + LQE L+E N S + Q
Sbjct: 1690 MYSAELEK----QKQLI----AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLD 1741
Query: 1817 EKEGGKNNIQAKQNL-ENVFDDVQKTL 1842
KE ++ + L + + DDVQK L
Sbjct: 1742 VKEEQIEELKRQNELRQEMLDDVQKKL 1768
Score = 191 bits (484), Expect = 9e-48
Identities = 324/1533 (21%), Positives = 654/1533 (42%), Gaps = 205/1533 (13%)
Query: 6 KQKISEEQQQLQQALAPAQASSNSSTPT-----RMRSRTSSFTE--QLDEGTPNRES--- 55
K++I EE + L+ + Q S+ + T R+ ++++S E +L + + E+
Sbjct: 343 KRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIM 402
Query: 56 -----GDTQSFAQ---KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDL 107
S A+ KL++R+ +E KE S KE L + S + N ++
Sbjct: 403 RLSSLNQDNSLAEDNLKLKMRIEVLE-------KEKSLLSQEKEEL-QMSLLKLNNEYEV 454
Query: 108 DSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQML 167
STA+ D +DSE DL LN E Q L + + + EL Q
Sbjct: 455 IKSTATRD--ISLDSELHDL-----RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507
Query: 168 QREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEE-FDASLEEKDQYISVLQT 226
+ ++ LS+ Q++ I++L+++L +++ L+++ D + E Q ++Q+
Sbjct: 508 TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567
Query: 227 QVSLLKQRLRNGPMNVDVLKPLPQLEPQAE--VFTKEENPESDGEPVVEDGTSVKTLETL 284
+V+L L + V + QL E V ++EN E L
Sbjct: 568 EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLE------------------L 609
Query: 285 QQRVKRQENLLKRCKETIQSHKEQCT------LLTSEKEALQEQLDERLQELEKIK---- 334
++ +++ E L R + + Q + L E+EA L + L ELE++
Sbjct: 610 KEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
Query: 335 ----DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
D+ M E KL+ D ++ +E+ + E K + ETL+M++ EI
Sbjct: 670 KVAFDVKM-ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEA---- 723
Query: 391 IKQMTTQGEELREQKEKSERAAFEELEKA----LSTAQKTEEARRKLKAEMDEQIKTIEK 446
++ + L E+ K E+ EEL A S Q E KL + D +I ++K
Sbjct: 724 --ELCWAKKRLLEEANKYEKT-IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL-ARKEQELTKKLQTRER 505
E+ + +E DV+ S EEQ Q +++KE+ K +E + KLQ
Sbjct: 781 NIEQ--------MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
Query: 506 EFQEQMK---VALEKSQSEYLKISQEKEQQESLA--LEELELQKKAILTESENKLRDLQQ 560
++ + ++ + + + + + KE+ L LE L ++ ++ K D
Sbjct: 833 KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892
Query: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
E + +++ ++ LE+ ++ ++ +D +N+ ++ +++ K E++ +
Sbjct: 893 ELASEVSQLNTIKEHLEEEIKHHQKIIED--------QNQSKMQLLQSLQEQKKEMDEFR 944
Query: 621 HQQDA-------LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-AHIEEMN 672
+Q + L+ EK + +K +T +E+++ + +E++ + D IFQ ++ +N
Sbjct: 945 YQHEQMNATHTQLFLEKDEEIKSLQKT-IEQIKTQLHEERQDIQTDNSDIFQETKVQSLN 1003
Query: 673 -EKTLEKLDVKQTELESLSSELSE-VLKARHKLEEELSVLK-------DQTDKMKQELEA 723
E EK D+ + E E L + E L+ + E+ +S+ K D+ K+ Q ++
Sbjct: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063
Query: 724 KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK---HLKEHQAHVE 780
K E + H + + + V +Q+ +A + ++ +L E+ + HLK +
Sbjct: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123
Query: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL-QQKLLDLET-----E 834
++ A + + +LQ + KL ++S+ + + + L+++ ++K ++++ +
Sbjct: 1124 DIVAAKEAALIKLQDENKKLST--RFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQ 1181
Query: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
+L Q + + V + +Q +D ++Q K+ E +Q+V + Q + +
Sbjct: 1182 TLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQ 1241
Query: 895 GNKEQEQTK-QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE 953
+E Q + Q+LV+ +N KL + E+ ETK KN
Sbjct: 1242 LQEELHQLQAQVLVDSDN----------------NSKLQVDYTGLIQSYEQNETKLKNFG 1285
Query: 954 KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
+++ +V+ ++ T K LL + + +L + +L Q + A E+ +S
Sbjct: 1286 QELAQVQHSIGQLCNT-KDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344
Query: 1014 ISDAVSRLETNQKEQ---IESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKE 1070
+ + L + +E+ I +L E + R + + + E + + + EI QL+EK+
Sbjct: 1345 LQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK--QLKEKQ 1402
Query: 1071 QEVAEL-KQKILLFGC-----------------EKEEMNKEITWLKEEGVKQDTTLNELQ 1112
+ +L K+K LL E E + + +T LKE + + + +L+
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLK 1462
Query: 1113 -------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
E + K +L + K L + E + + S+KE EQL++ K E
Sbjct: 1463 GENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECH-SMKEKALAFEQLLKEK---E 1518
Query: 1166 EDKR-KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
+ K ++++L + +K+ E+ + ++ +L+ K +E L E+ D +
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN 1578
Query: 1225 EALLEAKTNELINISSSKTNAILS---RISHCQHRTTKVKEALLIKTCTVS----ELEAQ 1277
+ L E N L+ S T L+ R + + + T ++E L+ + + + Q
Sbjct: 1579 QEL-ERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQ 1637
Query: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
+ L E+ N ++ + QL + Q+K + +L E Q+E A EK
Sbjct: 1638 VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK 1697
Query: 1338 ESCITQLKKELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
+ + K+ +EN+ V ++E L E + S S+ L+V KE I
Sbjct: 1698 QKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV----------KEEQI 1747
Query: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
L++Q +E + E+LD VQ + S+ K+
Sbjct: 1748 EELKRQ-NELRQEMLDDVQKKLMSLANSSEGKV 1779
Score = 162 bits (411), Expect = 3e-39
Identities = 249/1266 (19%), Positives = 528/1266 (41%), Gaps = 130/1266 (10%)
Query: 6 KQKISEEQQQLQQALAPAQASSNSS--TPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
K I++E ++ L ++ + N T ++ + + +QL++ + S ++
Sbjct: 550 KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLEL 609
Query: 64 KLQLRVPSVE-SLFRSPIKESLFRSSS---KESLVRTSSRE---------SLNRLDLDSS 110
K +R E S R+ + +SL + S+ K++L++ E L +L+ +
Sbjct: 610 KEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
Query: 111 TASFDPP----------SDMDSEAED-LVGNSD-SLNKEQLIQRLR-------------- 144
+FD D+ + E+ L GN+ SL K +++ L+
Sbjct: 670 KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAK 729
Query: 145 -RMERSLSSYRGKYSELVTAYQM----LQREKKKLQGILSQSQDKSLRRIAELREELQMD 199
R+ + Y EL A + LQ E + L + +Q K + IAEL++ ++
Sbjct: 730 KRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL---IKLNQKKDME-IAELKKNIEQM 785
Query: 200 QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVF- 258
K ++ +SLEE+ Q ++ + +++ + L Q + E+
Sbjct: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILR 845
Query: 259 -TKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
T EE S G E+ + LE L++ R + +T+ S E + + S+
Sbjct: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVAD--PKTLDSVTELASEV-SQLN 902
Query: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
++E L+E ++ +KI + K +L+ L++ K E D+ E H L
Sbjct: 903 TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK-----EMDEFRYQHEQMNATHTQL 957
Query: 378 EM-KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 436
+ K+EEI L+ I+Q+ TQ E R+ + F+E + + E KAE
Sbjct: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
Query: 437 MDEQIKTIE------KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--- 487
+ +K I+ K E+ ISL +++ ++ ++ V + + +++ ++Q LH +
Sbjct: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
Query: 488 -----ELARKEQELTKKLQTREREFQEQMKVALEKS--QSEYLKISQEKEQQESLALEEL 540
++ +Q+L RE+ F + E S ++EY K+ +E+ AL +L
Sbjct: 1078 TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA-ALIKL 1136
Query: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
+ + K + T E+ +D+ +E +RI+ E +E K Q+ + + N+
Sbjct: 1137 QDENKKLSTRFESSGQDMFRETIQNLSRIIR-EKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
Query: 601 HNKEITVMVEKHKTELESLKHQQDAL--WTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658
+ E+ E + LK Q + W +++ Q Q E +L+E+ Q + +L
Sbjct: 1196 AGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
Query: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
D + + ++ ++ + +T+L++ EL++V + +L +L + D +
Sbjct: 1256 DSDNNSKLQVDYTG--LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS 1313
Query: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
+L + Q + + + + + L+ ++ +L L+E+D ++ Q +
Sbjct: 1314 PQLSS----ASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQEN 1369
Query: 779 VENLEADI-----------KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
L I ++++ E++Q K DV Q KA +QL +
Sbjct: 1370 NHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN 1429
Query: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME-QKVKSLTQ 886
+ E LL + V + +++ + E+D K++ ++ + E E Q ++
Sbjct: 1430 FTNKVNENELLRQAVTNL--KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNM 1487
Query: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
+ L + E K+ + E ++ + +G+ E+ L + + ++ + +E
Sbjct: 1488 KFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQE-- 1545
Query: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
++Q K KQ + ++L D+E + +ELE L + E + + L
Sbjct: 1546 ---RDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL-A 1601
Query: 1007 AQANSAGISDAVSRLE------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
A+ A + V+ LE +N E V L + +++ K+ ++ A +L
Sbjct: 1602 AEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL-S 1660
Query: 1061 IHEIQLQEKEQEVAEL--------KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
+ + Q+++ +A L +++ ++ E E+ + I K+ + + LQ
Sbjct: 1661 VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720
Query: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL----VELKMLAEEDK 1168
E L + +A ++S ++L L+ E + + ++N QE L +L LA +
Sbjct: 1721 ECLDEANAALDS----ASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
Query: 1169 RKVSEL 1174
KV ++
Sbjct: 1777 GKVDKV 1782
Score = 124 bits (312), Expect = 8e-28
Identities = 224/1061 (21%), Positives = 427/1061 (40%), Gaps = 173/1061 (16%)
Query: 11 EEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVP 70
EEQ+QL Q + + +++ R+S E+LD+ ++Q L+
Sbjct: 801 EEQKQLTQLINKKEIFIE-----KLKERSSKLQEELDK------------YSQALRKN-- 841
Query: 71 SVESLFRSPIKESLFRSSSKESLVRTSSRESLNRL-DLDSSTASFDPPSDMDSEAEDLVG 129
+ R I+E RS +E L RL + S TA P +DS E L
Sbjct: 842 ---EILRQTIEEK-DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTE-LAS 896
Query: 130 NSDSLN-----------------------KEQLIQRLRRMERSLSSYRGKYSELVTAYQM 166
LN K QL+Q L+ ++ + +R ++ ++ +
Sbjct: 897 EVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQ 956
Query: 167 LQREKKKLQGILSQSQDKSLRRIAELREELQMD-----QQAK------KHLQEEFDASLE 215
L EK + L ++ ++ ++ E R+++Q D Q+ K ++ E+ D S
Sbjct: 957 LFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKA 1016
Query: 216 EKDQYISVL---QTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
E ++ + + + ++ LL ++ N+ + K + QL +K+E
Sbjct: 1017 ETERLVKGIKERELEIKLLNEK------NISLTKQIDQL-------SKDEVG-------- 1055
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-----KEQCTLLTSEKEALQEQLDERL 327
K + +QQ+ + L R T + ++Q E+E + L+E+
Sbjct: 1056 ------KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKT 1109
Query: 328 QE-------LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK 380
+E K+ D+ A++ LI + K L + E + ET + + + K
Sbjct: 1110 RENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREK 1169
Query: 381 EEEIAQLRSR------IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
+ EI L + + Q ++ G E +E +K +K EE +
Sbjct: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK---- 1225
Query: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
+Q+ T + + E LQ+EL +++ +V+ + +KLQ + + EQ
Sbjct: 1226 ----QQVMTTVQNMQHESAQLQEELHQLQAQVL-----VDSDNNSKLQVDYTGLIQSYEQ 1276
Query: 495 ELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQQESLAL------EELELQKKA 546
TK + Q Q + + + L K+ Q S +L E L K
Sbjct: 1277 NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE 1336
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD-LAVHLEAEKNKHNK-- 603
+L+ES L QQE E R + E ++++ ++LQEN ++ D +A E E+ +H +
Sbjct: 1337 VLSESSELL---QQELEELRKSLQEKDATI-RTLQENNHRLSDSIAATSELERKEHEQTD 1392
Query: 604 -EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE-KCEQEKETLLKDKE 661
EI + EK L+ L ++D L K L + K+ E + ++ T LK++
Sbjct: 1393 SEIKQLKEKQDV-LQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERI 1451
Query: 662 IIFQAHIEEM---NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
+I + I ++ NEK +E K+TE ++L + + E E +K++ +
Sbjct: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFE 1511
Query: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Q L+ K ++ K Q+ + +K S+Q + + +Q+ L LK++ Q
Sbjct: 1512 QLLKEK-EQGKTGELNQLLNAVK----SMQEKTVVFQQERDQVMLALKQKQMENTALQNE 1566
Query: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL- 837
V+ L RS EL++ L +S S T E A E++ A+L++K+ LE + +
Sbjct: 1567 VQRLRDKEFRSNQELERLRNHL--LESEDSYTREALAA-EDREAKLRKKVTVLEEKLVSS 1623
Query: 838 -----------------LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
L +Q+ V Q+ + +L + QV+ L +E
Sbjct: 1624 SNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHF 1683
Query: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE------GQKKEIEILTQKLSAK 934
+ +Y ++LE + + K+ E ++ ++E LT++L K
Sbjct: 1684 QQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVK 1743
Query: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
E+ I L + E + + + +K+ A + + K L+
Sbjct: 1744 EEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM 1784
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 969 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1020
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1021 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1135
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1136 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1302
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1357
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1358 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1392
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1393 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1627
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1628 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1731
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1792 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1847
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1899
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1900 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1938
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1994
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1995 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2051 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2109 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2216
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2217 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2325
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2384
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2505 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2556 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2605 HRAALAHS 2612
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1019
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1020 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1070
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1071 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1130 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1183
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1184 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1300
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1301 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1346
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1519 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1541
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1542 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1596 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1696
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1808
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1862
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1919
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2036
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2210
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2211 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2262
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2323 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2363 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2395
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2437
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 685 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 744
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 745 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 801
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 922 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 981 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1036
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1088
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1089 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1146
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1147 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1199
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1200 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1247
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1248 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1362
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1363 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1420 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1653
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1825
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1826 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1927
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1928 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1966
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1967 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2020
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2081 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2128
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2129 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2167
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2168 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2335
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2336 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2386
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2500
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1419
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1478
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1531
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1649
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1708
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1709 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1760 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1814
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1992 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2348
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2407 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2459
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2514 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2564
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2565 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2654
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1601
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1602 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1646
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1647 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1705 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1762
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1883 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 1997
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2055
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2056 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2110 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2155
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2211
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2212 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2269
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2327
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2446
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2447 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2564
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2565 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 566 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 625
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 626 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 684
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 685 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 743
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 744 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 803
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 804 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 863
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 864 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 921
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 922 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 980 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1039
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1040 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1215
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1216 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1275
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1396 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1626
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1916
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2031
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2032 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2083
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2084 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2201 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2255 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2309
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2149 A 2149
A
Sbjct: 2370 A 2370
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 366 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 422
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 423 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 479
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 480 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 522
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 523 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 583 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 642
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 643 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 702
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 703 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 754
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 755 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 813
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 814 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 873
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 874 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 933
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 934 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 994 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1053
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1113
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1114 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1221
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1281
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1337
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 973 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1024
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1025 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1081
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1082 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1139
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1140 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1306
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1361
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1362 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1396
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1397 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1631
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1632 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1735
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1796 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1851
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1903
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1904 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1942
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1998
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1999 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2055 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2113 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2220
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2221 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2329
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2388
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2509 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2560 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2609 HRAALAHS 2616
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 966 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1023
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1024 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1074
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1075 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1134 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1187
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1188 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1304
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1305 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1350
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1523 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1545
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1546 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1600 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1700
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1812
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1813 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1866
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1923
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2040
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2214
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2215 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2266
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2327 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2367 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2399
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2400 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2441
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 689 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 748
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 749 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 805
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 806 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 865
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 866 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 926 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 984
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 985 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1040
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1041 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1092
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1093 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1150
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1151 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1203
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1204 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1251
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1252 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1366
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1367 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1424 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1657
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1829
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1830 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1877
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1878 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1931
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1932 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1970
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1971 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2024
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2085 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2132
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2133 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2171
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2172 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2339
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2340 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2390
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2451 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2504
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1307 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1423
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1482
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1535
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1653
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1712
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1713 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1764 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1818
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1995
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1996 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2352
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2410
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2411 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2463
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2518 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2568
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2569 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2658
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1605
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1606 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1650
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1651 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1709 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1766
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1887 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 2001
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2059
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2060 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2114 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2159
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2215
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2216 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2273
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2274 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2331
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2391
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2450
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2451 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2568
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2569 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 570 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 629
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 630 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 688
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 689 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 747
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 748 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 807
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 808 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 867
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 868 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 925
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 926 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 983
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 984 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1043
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1044 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1103
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1163
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1164 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1219
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1220 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1279
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1280 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1339
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1340 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1400 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1630
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1750
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1810
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1920
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2035
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2036 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2087
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2088 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2145 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2204
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2205 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2259 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2313
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373
Query: 2149 A 2149
A
Sbjct: 2374 A 2374
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 370 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 426
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 427 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 483
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 484 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 526
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 527 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 586
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 587 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 646
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 647 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 706
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 707 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 758
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 759 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 817
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 818 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 877
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 878 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 937
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 938 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 997
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 998 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1057
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1058 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1117
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1118 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1225
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1285
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1341
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1461
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 969 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1020
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1021 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1077
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1135
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1136 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1302
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1357
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1358 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1392
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1393 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1627
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1628 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1731
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1792 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1847
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1899
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1900 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1938
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1994
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1995 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2051 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2109 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2216
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2217 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2325
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2384
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2505 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2556 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2605 HRAALAHS 2612
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 962 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1019
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1020 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1070
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1071 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1130 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1183
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1184 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1300
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1301 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1346
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1519 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1541
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1542 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1596 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1696
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1808
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1862
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1919
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2036
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2210
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2211 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2262
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2323 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2363 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2395
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2437
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 685 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 744
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 745 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 801
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 922 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 981 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1036
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1088
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1089 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1146
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1147 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1199
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1200 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1247
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1248 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1362
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1363 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1420 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1653
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1825
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1826 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1927
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1928 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1966
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1967 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2020
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2081 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2128
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2129 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2167
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2168 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2335
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2336 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2386
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2500
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1303 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1419
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1478
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1531
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1649
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1708
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1709 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1760 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1814
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1992 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2348
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2407 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2459
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2514 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2564
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2565 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2654
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1601
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1602 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1646
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1647 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1705 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1762
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1883 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 1997
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2055
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2056 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2110 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2155
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2211
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2212 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2269
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2327
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2446
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2447 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2564
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2565 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 566 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 625
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 626 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 684
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 685 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 743
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 744 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 803
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 804 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 863
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 864 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 921
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 922 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 980 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1039
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1040 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1215
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1216 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1275
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1335
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1336 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1396 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1626
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1746
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1916
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2031
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2032 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2083
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2084 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2201 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2255 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2309
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2149 A 2149
A
Sbjct: 2370 A 2370
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 366 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 422
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 423 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 479
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 480 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 522
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 523 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 582
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 583 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 642
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 643 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 702
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 703 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 754
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 755 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 813
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 814 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 873
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 874 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 933
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 934 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 994 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1053
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1113
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1114 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1221
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1281
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1337
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 937 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 988
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 989 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1045
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1046 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1103
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1104 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1270
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1325
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1326 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1360
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1361 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1595
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1596 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1699
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1760 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1815
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1867
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1868 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1906
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1962
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1963 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2019 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2077 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2184
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2185 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2293
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2352
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2473 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2524 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2573 HRAALAHS 2580
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 930 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 987
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 988 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1038
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1039 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1098 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1151
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1152 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1268
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1269 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1314
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1315 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1487 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1509
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1510 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1564 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1664
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1776
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1777 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1830
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1831 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1887
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2004
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2178
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2179 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2230
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2291 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2331 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2363
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2364 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2405
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 653 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 712
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 713 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 769
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 770 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 829
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 830 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 890 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 948
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 949 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1004
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1005 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1056
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1057 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1114
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1115 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1167
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1168 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1215
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1216 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1330
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1331 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1388 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1621
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1793
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1794 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1841
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1842 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1895
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1896 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1934
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1935 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 1988
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2049 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2096
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2097 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2135
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2136 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2303
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2304 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2354
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2415 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2468
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1271 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1387
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1446
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1499
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1617
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1676
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1677 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1728 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1782
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1959
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1960 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2316
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2374
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2375 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2427
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2482 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2532
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2533 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2622
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1569
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1570 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1614
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1615 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1673 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1730
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1851 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1908
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 1965
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2023
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2024 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2078 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2123
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2179
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2180 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2237
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2238 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2295
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2355
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2414
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2415 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2532
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2533 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 534 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 593
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 594 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 652
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 653 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 711
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 712 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 771
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 772 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 831
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 832 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 889
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 890 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 947
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 948 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1007
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1008 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1067
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1127
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1128 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1183
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1184 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1243
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1244 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1303
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1304 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1364 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1594
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1714
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1774
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1884
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 1999
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2000 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2051
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2052 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2109 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2168
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2169 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2223 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2277
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2337
Query: 2149 A 2149
A
Sbjct: 2338 A 2338
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 334 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 390
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 391 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 447
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 448 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 490
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 491 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 550
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 551 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 610
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 611 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 670
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 671 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 722
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 723 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 781
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 782 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 841
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 842 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 901
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 902 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 961
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 962 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1021
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1022 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1081
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1082 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1189
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1249
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1305
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1425
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 1106 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1157
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1158 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1214
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1215 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1272
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1273 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1439
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1494
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1495 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1529
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1530 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1764
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1765 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1868
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1929 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1984
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 2036
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 2037 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 2075
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 2131
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 2132 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2188 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2246 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2353
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2354 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2462
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2521
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2642 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2693 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2742 HRAALAHS 2749
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 1099 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1156
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1157 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1207
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1208 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1267 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1320
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1321 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1437
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1438 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1483
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1656 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1678
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1679 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1733 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1833
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1945
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1946 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1999
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 2000 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 2056
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2173
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2347
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2348 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2399
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2460 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2500 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2532
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2533 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2574
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 822 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 881
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 882 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 938
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 939 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 998
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 1059 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1117
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 1118 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1173
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1174 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1225
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1226 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1283
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1284 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1336
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1337 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1384
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1385 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1499
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1500 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1557 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1790
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1962
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1963 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 2010
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 2011 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 2064
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 2065 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 2103
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 2104 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2157
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2218 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2265
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2266 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2304
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2305 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2472
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2473 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2523
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2637
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1440 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1556
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1615
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1668
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1786
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1845
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1846 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1897 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1951
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 2128
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 2129 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2485
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2543
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2544 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2596
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2651 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2701
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2702 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2791
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1738
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1739 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1783
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1784 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1842 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1899
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 2020 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 2134
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2192
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2193 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2247 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2292
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2348
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2349 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2406
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2407 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2464
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2524
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2583
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2584 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2701
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2702 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 703 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 762
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 763 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 821
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 822 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 880
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 881 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 940
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 941 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 1000
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 1001 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 1058
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 1059 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1116
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 1117 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1176
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1177 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1236
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1296
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1297 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1352
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1353 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1412
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1472
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1473 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1533 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1763
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1883
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1943
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 2053
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2168
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2169 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2220
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2221 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2337
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2338 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2392 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2446
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2506
Query: 2149 A 2149
A
Sbjct: 2507 A 2507
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 503 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 559
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 560 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 616
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 617 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 659
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 660 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 719
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 720 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 779
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 780 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 839
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 840 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 891
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 892 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 950
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 951 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 1010
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 1011 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 1070
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 1071 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1130
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 1131 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1190
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1191 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1250
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1251 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1358
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1418
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1474
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1594
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 947 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 998
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 999 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1055
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1056 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1113
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1114 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1280
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1335
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1336 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1370
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1371 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1605
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1606 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1709
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1770 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1825
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1877
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1878 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1916
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1972
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1973 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2029 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2087 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2194
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2195 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2303
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2362
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2483 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2534 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2583 HRAALAHS 2590
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 940 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 997
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 998 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1048
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1049 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1108 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1161
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1162 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1278
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1279 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1324
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1325 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1497 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1519
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1520 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1574 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1674
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1786
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1787 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1840
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1897
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2014
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2188
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2189 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2240
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2301 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2341 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2373
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2374 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2415
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 663 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 722
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 723 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 779
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 780 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 839
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 840 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 900 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 958
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 959 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1014
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1015 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1066
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1067 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1124
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1125 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1177
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1178 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1225
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1226 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1340
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1341 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1398 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1631
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1803
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1804 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1851
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1852 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1905
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1906 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1944
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1945 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 1998
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2059 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2106
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2107 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2145
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2146 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2313
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2314 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2364
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2478
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1397
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1456
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1509
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1627
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1686
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1687 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1738 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1792
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1969
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1970 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2208
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2326
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2384
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2385 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2437
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2492 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2542
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2543 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2632
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1579
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1580 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1624
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1625 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1683 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1740
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1861 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 1975
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2033
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2034 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2088 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2133
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2189
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2190 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2247
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2248 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2305
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2365
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2424
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2425 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2542
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2543 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 544 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 603
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 604 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 662
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 663 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 721
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 722 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 781
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 782 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 841
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 842 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 899
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 900 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 957
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 958 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1017
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1018 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1077
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1137
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1138 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1193
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1194 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1253
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1313
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1314 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1374 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1604
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1724
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1784
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1894
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2009
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2010 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2061
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2062 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2178
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2179 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2233 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2287
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2347
Query: 2149 A 2149
A
Sbjct: 2348 A 2348
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 344 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 400
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 401 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 457
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 458 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 500
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 501 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 560
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 561 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 620
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 621 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 680
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 681 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 732
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 733 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 791
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 792 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 851
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 852 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 911
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 912 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 971
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 972 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1031
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1032 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1091
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1092 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1199
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1259
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1315
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 955 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1006
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1007 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1063
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1064 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1121
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1122 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1288
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1343
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1344 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1378
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1379 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1613
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1614 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1717
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1778 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1833
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1885
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1886 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1924
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 1980
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 1981 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2037 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2095 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2202
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2203 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2311
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2370
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2491 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2542 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2591 HRAALAHS 2598
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 948 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1005
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1006 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1056
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1057 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1116 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1169
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1170 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1286
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1287 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1332
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1505 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1527
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1528 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1582 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1682
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1742
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1794
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1795 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1848
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1849 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1905
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2022
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2196
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2197 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2248
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2309 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2349 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2381
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2382 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2423
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 671 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 730
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 731 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 787
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 788 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 847
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 848 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 908 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 966
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 967 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1022
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1023 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1074
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1075 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1132
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1133 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1185
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1186 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1233
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1234 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1348
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1349 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1406 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1639
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1811
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1812 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1859
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1860 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1913
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1914 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1952
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1953 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2006
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2067 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2114
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2115 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2153
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2154 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2321
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2322 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2372
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2433 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2486
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1289 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1405
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1464
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1517
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1635
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1694
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1695 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1746 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1800
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 1977
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 1978 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2097 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2156
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2157 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2216
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2334
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2392
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2393 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2445
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2499
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2500 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2550
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2551 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2640
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1587
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1588 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1632
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1633 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1691 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1748
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1869 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1926
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 1983
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2041
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2042 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2096 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2141
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2197
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2198 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2255
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2256 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2313
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2373
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2432
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2433 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2550
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2551 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 552 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 611
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 612 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 670
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 671 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 729
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 730 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 789
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 790 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 849
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 850 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 907
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 908 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 965
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 966 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1025
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1026 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1085
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1145
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1146 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1201
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1202 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1261
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1262 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1321
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1322 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1382 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1612
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1732
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1792
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1902
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2017
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2018 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2069
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2070 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2127 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2186
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2187 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2241 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2295
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2355
Query: 2149 A 2149
A
Sbjct: 2356 A 2356
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 352 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 408
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 409 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 465
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 466 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 508
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 509 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 568
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 569 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 628
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 629 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 688
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 689 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 740
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 741 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 799
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 800 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 859
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 860 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 919
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 920 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 979
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 980 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1039
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1040 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1099
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1100 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1207
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1267
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1323
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1443
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 213 bits (541), Expect = 2e-54
Identities = 351/1808 (19%), Positives = 773/1808 (42%), Gaps = 261/1808 (14%)
Query: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ-ELEKIKDLHMA 339
L++L+Q + + RC+ I K+ + + EA + + RL+ L+K A
Sbjct: 996 LQSLEQGAQEES----RCQRCISELKD----IRLQLEACETRTVHRLRLPLDKEPARECA 1047
Query: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKR------------QMHETLEMKEEEIAQL 387
++ I + + A+ +E L + + AE ++ + LE+ ++ Q+
Sbjct: 1048 QR---IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV 1104
Query: 388 RS-------RIKQMT-----TQGEE--LREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
RS ++K ++ TQG E LR +E+ + A + + L + T+ + +KL
Sbjct: 1105 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATKASLKKL 1162
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--ELAR 491
+A+ + Q T + +L+ EL R QEV + +++ E+ ++++ E+ +L
Sbjct: 1163 RAQAEAQQPTFD--------ALRDEL-RGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213
Query: 492 KEQELTKKLQTREREFQE---QMKVALEKSQ--SEYLKISQEKEQQ-------ESLALEE 539
+ Q + + R+RE ++ Q++ E + +L+ ++ +++Q +S A+ E
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
Query: 540 LELQKKAILTESEN---KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA 596
Q++A+L E E K+ + Q+ A+ Y I + E L K Q + +A +
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY----KAQLEPVASPAKK 1329
Query: 597 EKNKHNKEITVM----VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
K + E + + H +EL +L Q +E L+ ++++ E+L E+ E
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-----ERLAEQQRAE 1384
Query: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
+ L + E + KQ +L ++ A+ + E E K+
Sbjct: 1385 ERERLAEVEAALE----------------KQRQLAEAHAQ------AKAQAEREA---KE 1419
Query: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER---D 769
+M++E+ + +E QQQ SI +E + Q +E ++ + Q E + R +
Sbjct: 1420 LQQRMQEEV-VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
+ ++ + +E E +EGELQ A+ + ++ + E+ + Q+ Q+
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-------- 881
E E K AE +K+ L+ ++Q ++ ++L + E ++V
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
Query: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
+S +SK ++ Q ++ L E+ + Q+RE ++ + + A+E++
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA---- 1654
Query: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
E+++E+ + KA E L+ +L +E +K L E ++E + A
Sbjct: 1655 -----------ERELERWQLKANE---ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
Query: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
+ A+ + + + Q++ E + ++I + + +Q E+ +++
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQGEQQRQL 1758
Query: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD----TTLNELQEQLKQ 1117
E +L ++E A QK E ++ E+ L + + +T + +++L+
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
++ LA++ +L+A E E + L E +++ ++LAE+ + E T +
Sbjct: 1819 EAGRFRELAEEAARLRALAE--EAKRQRQLAEEDAARQRAEAERVLAEK-LAAIGEAT-R 1874
Query: 1178 LKTTDE-EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236
LKT E + ++ +E+ + ED++ + ++L E+ A + +A +E + +L
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA--------QHKADIEERLAQLR 1926
Query: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
S S+ + + V++ L Q RQ+ EE L SF++A
Sbjct: 1927 KASDSEL----------ERQKGLVEDTL-----------RQRRQVEEEILALKASFEKAA 1965
Query: 1297 HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
E E ++ ++++ E + KE + E Q+Q A+E+E + ++E E +
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE----RRRREAEERVQKSL 2021
Query: 1357 LMKEEL-KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
+EE +++K + + + L +++ + L E+ S+ + Q +E + Q +
Sbjct: 2022 AAEEEAARQRKAALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
+ + KE+ L+Q + + + +E ++Q E ++ ++
Sbjct: 2078 EKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
+ E+ LK+ ++Q + +++ + L E + + AR + E
Sbjct: 2136 RQVEEAERLKQSAEEQAQA-----------RAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
++ ++ E K + +Q + ++ Q+L + EE D++ +E++ L+ +
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA- 2243
Query: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
E ++ ++E SV+ + EEL L+ R+E+E+ A + K ++ + +++
Sbjct: 2244 ---TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300
Query: 1656 LSQMEEKEEQYKKGTES-HLSELNTK--LQEREREVHILEEKLKSVESSQSETLIVPRSA 1712
EE E+ L +L + Q+R +L+EK+++V+ +
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--------L 2352
Query: 1713 KNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
K A +Q++ +Q ++ E+K + Q+ E + + + E++ + E +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE-R 2411
Query: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV---------------- 1816
+ R+ ++ A+A+ ED EE+ EK + L + V
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 1817 ---------EKEGGKNNIQAKQNLENVFDDVQKTLQEKELT--CQILEQK-IKELDSCLV 1864
E E K +Q + L + + +T+Q+++L Q L+Q + E DS L
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
R++ + + + KL+ L Q D K +L EE ++ + + +L+++ME
Sbjct: 2532 RERFIEQEKA--------KLEQLFQ-DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQ 1983
G R+++ +L+ L ++ +Q+ E+L +E + RE+ ++ +EQ
Sbjct: 2583 RRRQHEAEEGVRRKQE-----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Query: 1984 EDLELKHN 1991
L H+
Sbjct: 2632 HRAALAHS 2639
Score = 209 bits (531), Expect = 3e-53
Identities = 386/1850 (20%), Positives = 766/1850 (41%), Gaps = 285/1850 (15%)
Query: 304 SHKEQCTLLTSEKEALQEQLDER-LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
SH Q L + E+ A +E +R + EL+ I+ A +T+ + +LR L ++ ++
Sbjct: 989 SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR--LPLDKEPAREC 1046
Query: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
IAE ++ + E+ L + +++ + E++ E S A E L T
Sbjct: 1047 AQRIAEQQKA--------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL-T 1097
Query: 423 AQKTEEARRKLKAEMDEQIKTIEK----TSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478
K E+ R L A E++KTI T E + E + + V E
Sbjct: 1098 LGKLEQVR-SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156
Query: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
A L+KL + A +Q L+ R QE E+ Q + + E E+ +
Sbjct: 1157 ASLKKLRAQ--AEAQQPTFDALRDELRGAQE----VGERLQQRHGERDVEVERWRERVAQ 1210
Query: 539 ELELQKKAILTESENKLRDLQQ---EAETYRTRILELESSLEKSLQENKN-QSKDLA-VH 593
LE + +A+L +++ + R+L+Q + YR L + L+ + + + Q+ LA
Sbjct: 1211 LLE-RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 594 LEAEKNKHNKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
E+ + + + +E+H ++E K +A+ +LQ++ Y+ ++E +
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT--YKAQLEPVASPA 1327
Query: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE----LSEVLKARHKLEE 705
++ K + E + Q +++ L +EL +L+S+ +SE L+ ++EE
Sbjct: 1328 KKPK--VQSGSESVIQEYVD---------LRTHYSELTTLTSQYIKFISETLR---RMEE 1373
Query: 706 ELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
E + + Q + ++ E+EA +++Q+ + + H + + E+ K+ +++
Sbjct: 1374 EERLAEQQRAEERERLAEVEAALEKQRQ--------LAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 763 LLLKERDKHLKEHQAHVENLEADIKR----SEGELQQASAKLDVFQSYQSATHEQTKAYE 818
+ R++ + Q +++ ++++ SE E+Q + + + + + E+ +
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
QL +++ E E L + E EAQK+ E + + QVQD Q+ + E+
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
+VK+ + +E+++ Q L E +
Sbjct: 1546 SRVKAEAEAA--------REKQRALQALEE-----------------------------L 1568
Query: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
+ EE E + + E ++A+++Q L+ EA+L+ + + A + +Q E+
Sbjct: 1569 RLQAEEAERRLRQAEV------ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
Query: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
+ + +AQ R E ++ Q ++ E R E + W+ K N+
Sbjct: 1623 LQEEHVAVAQL----------REEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
+ E+ Q+ + KQK E E + +E+ V+Q EL EQ +K
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKE-----EAEREARRRGKAEEQAVRQ----RELAEQELEK 1723
Query: 1119 SAHV-NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
+ AQ + L +L + + ++ L+E+L L+ A +K EL ++
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783
Query: 1178 LKTTDEEFQSL-----------KSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
L E + L +S+ EKS + LE ++ F++L+EE A + A
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA--------RLRA 1835
Query: 1227 LLEA--KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
L E + +L +++ A R+ + + EA +KT E E L++ E
Sbjct: 1836 LAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKT----EAEIALKEKEAE 1889
Query: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
L + Q E Q KADIE + + L+K ++ + +
Sbjct: 1890 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ---LRKASDSELERQKGLVEDTLRQ 1946
Query: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS-SLRKQY 1403
++++ E I A+ E+ K E+ ++ S +E EAA L +
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
+ + E ++VQ + ++++ +ALE+V+ K E ++ R Q + ++L
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL---RERAEQESARQL 2063
Query: 1464 QIQLELKSKE--------AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK-KES 1514
Q+ E K A+ ++ L++ L Q+ D L+GE E + E+ +E+
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 1515 NLETELKS--------QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
++ E ++ + R+ + + Q + ++ E L+ +Q+ + Q
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183
Query: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
++ + + + K+ E+ L + QV + EL T + +LE + +EEL+
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQV---EQELTTLRLQLEETDHQKNLLDEELQ--- 2237
Query: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQER 1684
RL++E A + A + + E+++ +++ Q+ LS+++ + E E+ L K
Sbjct: 2238 -RLKAE-ATEAARQRSQVEEELFSVRVQMEELSKLKARIE-----AENRALILRDK-DNT 2289
Query: 1685 EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR- 1743
+R + EK+K V + + + A + E++ A + +K +EK+ +Q
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 1744 -NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
L + +LLQ Q++ + E A Q + + M L EE +
Sbjct: 2350 TRLKAEAELLQ--------------------QQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
G + ++A++ Q+ L E + L+ ++ E+
Sbjct: 2390 -----------------GFQRTLEAER---------QRQL-EMSAEAERLKLRVAEMSRA 2422
Query: 1863 LVRQKEV---HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
R +E R + EE+ K + TEL T+EK LVQ +
Sbjct: 2423 QARAEEDAQRFRKQAEEIGEKLHR-------------TELA---TQEKVT--LVQTLEIQ 2464
Query: 1920 NMEAQHND--LEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ-QELEILKKEYDQ 1973
++ H+ L +A EREK+KL +E LQ ++++ +++E QE + L++ +
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
Query: 1974 E------REEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK--ETINK 2022
E RE I+QE+ LE + +QL E Q Q EQE + + E +
Sbjct: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Q E + QEE QL ++ ++++ L +R E L EE+ A
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634
Score = 193 bits (491), Expect = 1e-48
Identities = 391/1976 (19%), Positives = 822/1976 (41%), Gaps = 280/1976 (14%)
Query: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-KEQCTLL-----TSEKEALQEQLDER 326
ED + T+E+ Q ++ Q + + + I++H KE E E ++L E
Sbjct: 712 EDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEA 771
Query: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
L+ K A T+L L+DA++ EQL + KG + KR +++K A
Sbjct: 772 LRR--KYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-AVVQLKPRHPAH 828
Query: 387 -LRSRIKQMTT-----------QGEELR----EQKEKSERAAFEELEKALSTA------- 423
+R R+ + +G+E + Q + + E A+ +
Sbjct: 829 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 888
Query: 424 -QKTEEARRKLKAEMDEQIKTIEKTSEEERI-----SLQQELSRVKQ---EVVDVMKKSS 474
Q+ +EA +L+A+ + + + + SL++++ ++ +K
Sbjct: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948
Query: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
+ Q +LH + R Q+ +R E+ + + L+ ++ Q+ES
Sbjct: 949 QRQALHSLELHYQAFLRDSQD-AGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1007
Query: 535 LA------LEELELQKKAILTESENKLR-DLQQE-AETYRTRILELESSLEKSLQENKNQ 586
L+++ LQ +A T + ++LR L +E A RI E + K+ E +
Sbjct: 1008 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ----KAQAEVEGL 1063
Query: 587 SKDLA-VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
K +A + EAEK E + ++ELE L KL+ ++ +EKL
Sbjct: 1064 GKGVARLSAEAEKVLALPEPSPAAPTLRSELE--------LTLGKLEQVRSLSAIYLEKL 1115
Query: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEK-----TLEKLDVKQTELESLSSELSEVLKAR 700
+ + T + E + +AH E++ E TL +L+ + L+ L ++
Sbjct: 1116 KTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1173
Query: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
L +EL ++ ++++Q + D + +++V +++ + + +T+ + Q
Sbjct: 1174 DALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQLLERWQAVLAQTD------VRQ 1226
Query: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
EL ++ + L+ ++ + L A LQ A + + Q+ A ++A EQ
Sbjct: 1227 REL--EQLGRQLRYYRESADPLGA-------WLQDARRRQEQIQAMPLA---DSQAVREQ 1274
Query: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ- 879
L Q Q L ++E ++V E + K + +++Q+ QLE S ++
Sbjct: 1275 LRQEQALLEEIERHG----EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
KV+S ++ + D + + + I + ++E + Q+ + + + +
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL- 1389
Query: 940 ILNEEYETKFKNQEKKME-------KVKQKAKEMQETLKKKLL----------DQEAKLK 982
E E + Q + E + +++AKE+Q+ ++++++ Q+ ++
Sbjct: 1390 ---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 983 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS----RLETNQKEQIESLTEVHR- 1037
+EL+ + S+ E Q A+ E A+ + I + + +LE ++++ + E+
Sbjct: 1447 EELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
R + +++ ++AE L+ + + Q K Q EL ++ E + + L
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 1098 KEEGVKQDTTLNELQEQLKQKSAHVN-SLAQDETKLKAHLEKLEVDL-NKSLKENTFLQE 1155
+E ++ + L++ +++ V +L + +A L+ K+ + LQE
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
+ V + L EE +R+ + + +E + L+ K+N++L + +EE+A
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQ 1680
Query: 1216 QLDICCKKTEALLEAKTNELINISSSKTNAILSR------------ISHCQHRTTKVKEA 1263
Q + + E E E ++ A+ R ++ + E
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1264 LLIKTCTVSELEAQLRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
LI+ +E Q RQL EE+ L AT + +E E ++ ++A++E L+ K
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
++E + + + ++ +EL+E + + EE K ++ QL + +
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR--------QLAEEDAA 1852
Query: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Q + E E ++ EK + + L + + KEK + E++ +
Sbjct: 1853 RQRA----EAERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1900
Query: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
+ +++ + + QH+ ++E QL S E+ Q L+++ L Q+ + ++ E+
Sbjct: 1901 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELER--QKGLVEDTLRQRRQ----VEEEI 1954
Query: 1503 EDDKSKMEKKESNLETELKSQTARIME-LEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
K+ EK + + EL+ + RI ED + K E E
Sbjct: 1955 LALKASFEKAAAG-KAELELELGRIRSNAEDTLRSK--------------------EQAE 1993
Query: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
L Q ++L E++ R +EAEE++ + + + + +K LE V +K+K EE
Sbjct: 1994 LEAARQ--RQLAAEEERRRREAEERV---QKSLAAEEEAARQRKAALEEVE-RLKAKVEE 2047
Query: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
+ L +R E ESA +L + A++++ A +K +++KE++ ++ + S L+
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
E E EE +E V + + + EEA+ ++++ EE+
Sbjct: 2108 GEAEAARRAAEE---------AEEARVQAEREAAQSRRQVEEAER---LKQSAEEQAQAR 2155
Query: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
+ EKL + QE R Q ++ ++ KQ D M
Sbjct: 2156 AQAQAAAEKLRKEAEQEAAR--------RAQAEQAALR-----QKQAADAEM-------- 2194
Query: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
EK+KK++ ++ + Q +Q L + +++T +K L + L++ E
Sbjct: 2195 -EKHKKFA--------EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 1862 CLVRQKEVH------RVEMEELTSKYEKLQA------LQQMDGRNK----PTELLEENTE 1905
++ +V RV+MEEL+ +++A L+ D + E +++ E
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
Query: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQ 1962
E ++ + + + DL + A AE +EK + +E RL+ + +L+++
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ--- 2362
Query: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
KE QE+ ++++++E + + + R T A+++++LEM+ + K
Sbjct: 2363 ------KELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQRQLEMSAEAERLK 2413
Query: 2023 AQEVEAELLESHQEETNQLLKKIAEK-DDDLKRTAKRYE---------EILDAREEEMTA 2072
+ E ++ EE Q +K AE+ + L RT + EI + +
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473
Query: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
++R+ +LE ++K QQ+ + + + T+ Q QL Q+T + S L E++
Sbjct: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKD 2527
Score = 179 bits (454), Expect = 3e-44
Identities = 287/1413 (20%), Positives = 595/1413 (42%), Gaps = 175/1413 (12%)
Query: 51 PNRESGDTQSFAQKLQLR-----VPSVESLFRSPIKESLFRSSSKESLV---RTSSRESL 102
P +SG + + LR + ++ S + I E+L R +E L R RE L
Sbjct: 1330 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 103 NRLD--LDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSEL 160
++ L+ + + ++AE +E+++ RR E ++ + + K S
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVDAQQQKRSIQ 1446
Query: 161 VTAYQMLQREKKKLQGILSQSQ--DKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Q+ Q + ++Q Q++ ++S RI E +R +L+ ++ + + E A L
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-L 1505
Query: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
+ + + Q +RLR + K ++E + V +++ E E
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAEAAREK 1558
Query: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
+++ LE L+ + + E L++ E ++ + Q L T+++ A E +R EK
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQA-EVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617
Query: 335 DLH--MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
L + E+ + QLR+ Q + + E +R++ E ++K E +LR + +
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL-ERWQLKANEALRLRLQAE 1676
Query: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
++ Q + + EK + A E + ++ R + E+++Q + E T+++ R
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-R 1735
Query: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
++ +QEL R++ E EQ + ++L E+ELAR ++E Q R+ E K
Sbjct: 1736 LAAEQELIRLRAET---------EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786
Query: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENKLRDLQQEAETY 565
V +++ E L S+ + ++ES + E Q+ L E +LR L +EA+
Sbjct: 1787 V---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK-- 1841
Query: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE---------- 615
R R L E + + + + ++ LA EA + K EI + ++ + E
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 616 -----LESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETL------ 656
LE Q A E+L L++ +E+E+ LR++ + E+E L
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 657 ------------------------LKDKEIIFQAHIEEMNEKTL------EKLDVKQTEL 686
L+ KE QA +E ++ L + + ++
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKE---QAELEAARQRQLAAEEERRRREAEERVQ 2018
Query: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMK-------QELEAKMDEQKNHHQQQVDSI 739
+SL++E E + R EE+ LK + ++ + QE ++ + Q+++ +
Sbjct: 2019 KSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
K H ++Q+ E+ L+ + Q + +L + + + E E ++E E Q+ +
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE---------RILLTKQVAEVEAQK- 849
++ + + + EQ +A + A ++ + E E L KQ A+ E +K
Sbjct: 2138 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2197
Query: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
K + K QV+ + L Q E + + L + + + + Q Q+ E
Sbjct: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2257
Query: 910 ENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKA 963
++ +QM E K + I + L K+++ L EE E + + ++ Q+A
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
+++ ++ L Q A +K L+ ++ Q+ + A+ E+ Q + RL+
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAE-AELLQQQKELAQEQARRLQE 2375
Query: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
++++ + L E + + + +++L AE E ++++ E + A ++ F
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE--AERLKLRVAEMSRAQARAEEDAQRF 2433
Query: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
+ EE+ +++ E ++ TL + E +Q+S H D +L+ + +LE +
Sbjct: 2434 RKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDH------DAERLREAIAELEREK 2486
Query: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
K +E LQ + E++ + +E +L + + + F S K S + + +E +
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQE------QLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540
Query: 1204 LEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
+ ++L +E+A K + L E + + + + + S + + R + +E
Sbjct: 2541 AKLEQLFQDEVA--------KAQQLREEQQRQQQQMEQERQRLVAS-MEEARRRQHEAEE 2591
Query: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
+ K + +LE Q RQ ++ L Q+ QL+ E Q ++ A E + + A
Sbjct: 2592 GVRRKQEELQQLEQQRRQ---QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 1323 LQKEGGNQQQ------AASEKESCITQLKKELS 1349
K N + A +E E L++++S
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS 2681
Score = 164 bits (414), Expect = 1e-39
Identities = 248/1198 (20%), Positives = 528/1198 (44%), Gaps = 140/1198 (11%)
Query: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
++L+Q E +Q+Q AL AQ S+ + ++S+ +SF E+ T E +
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAE----LQSKRASFAEK----TAQLERSLQEEHV 1628
Query: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
QLR + E + ++ R + L R L ++ A +
Sbjct: 1629 AVAQLREEA----------ERRAQQQAEAERAREEAERELERWQLKANEAL-----RLRL 1673
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT-----AYQMLQREKKKLQGI 177
+AE+ V SL + + ++ ER + RGK E A Q L+++++ +G
Sbjct: 1674 QAEE-VAQQKSLAQAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
+Q + + + + LR E + +Q ++ L+EE A L+ + + + ++ ++R
Sbjct: 1732 -AQQRLAAEQELIRLRAETEQGEQQRQLLEEEL-ARLQREAAAATQKRQELEAELAKVRA 1789
Query: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
+ K + E ++ ++ E++ E L L + KRQ L +
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 298 --CKETIQSH----------------KEQCTLLTSEKEALQEQL-----DERLQE--LEK 332
++ ++ K + + EKEA E+L DE Q LE+
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
Query: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMK--------- 380
H A+ + + QLR A + +LE+ KG+V + + ++ E L +K
Sbjct: 1910 QAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967
Query: 381 ----EEEIAQLRSRIKQMTTQGEE----------LREQKEKSERAAFEELEKALSTAQKT 426
E E+ ++RS + E+ L ++E+ R A E ++K+L+
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE--- 2024
Query: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
EEA R+ KA ++E + K E R+ + E +Q + + ++++++++ +K H
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ--LQLAQEAAQKRLQAEEKAHA 2082
Query: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
+ +KEQEL + LQ QEQ + + ++E + + E+ ++ + E Q +
Sbjct: 2083 FAVQQKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
+ E+E L+Q AE + +++ EK +E + ++ A +AE+
Sbjct: 2137 QVEEAER----LKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQ-------A 2182
Query: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
+ +K + E KH++ A T + + +Q T + E+ + +K L D+E+ Q
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--DEEL--QR 2238
Query: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL----KDQTDKMKQELE 722
E E ++ V++ EL S+ ++ E+ K + ++E E L KD T + QE E
Sbjct: 2239 LKAEATEAARQRSQVEE-ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-E 2296
Query: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
A+ +Q ++ +E Q E+ L Q E +LKE+ + ++E A
Sbjct: 2297 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE--ATRLKA 2354
Query: 783 EADIKRSEGELQQASAKLDVFQSYQSATH--EQTKAYEEQLAQLQQKLLDLETERILLTK 840
EA++ + + EL Q A+ Q A E+T+ ++ L +Q+ L++ E L
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2414
Query: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
+VAE+ + + + Q +++ ++L + ++KV +L Q E + + + + E
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV-TLVQTLEIQRQQSDHDAE 2473
Query: 901 QTKQILVEKENMILQMREGQKKEIEILTQKL-SAKEDSIHILNEEYETKFKNQEKKMEKV 959
+ ++ + E E ++++ + K +++ ++++ + +++ + + + F +++ + +
Sbjct: 2474 RLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 960 KQKAKEMQETLKKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
++ ++ + L++ D+ AK L++E + ++ Q+ ++ A M E A+ +
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEE 2591
Query: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
V R ++E+++ L E RR+ ++++ ++L +Q + L+E H L E+ A
Sbjct: 2592 GVRR----KQEELQQL-EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Query: 1077 KQKILLFGCEKEEMNKEITWLKEE----GVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
++ ++ + E G+++ + LQE + + LAQ T
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
Score = 148 bits (373), Expect = 7e-35
Identities = 354/1861 (19%), Positives = 757/1861 (40%), Gaps = 276/1861 (14%)
Query: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
E+ + +E+++S+ ++S L L+LQ +L S+ +LR L+
Sbjct: 593 EEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 652
Query: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
EL EK +E D ++ A+K ++ + + K K +++ L++ D L
Sbjct: 653 TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLLR 711
Query: 629 E------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-----AHIEEMNEKTLE 677
E ++ + QT+ + + C E LK+ FQ E +K E
Sbjct: 712 EDHPARPTVESFQAALQTQWSWMLQLC-CCIEAHLKENAAYFQFFSDVREAEGQLQKLQE 770
Query: 678 KLDVKQT-ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
L K + + + + L ++L+ +E+L+ K + + +A + + H +
Sbjct: 771 ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 830
Query: 737 DSII--------KEHEVSIQRTE-------------KALKDQ-----INQLELLLKERDK 770
+ K+ EV++ + + K L + + L+ ++
Sbjct: 831 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ 890
Query: 771 HLKE--------HQAHV---ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
+E HQA V L D+K S Q + + +S+ AT K EE
Sbjct: 891 EAQEAVTRLEAQHQALVTLWHQLHVDMK-SLLAWQSLRRDVQLIRSWSLATFRTLKP-EE 948
Query: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD--AHKIQVQDLMQQLEKQNSEM 877
Q L L+L + L Q A + + E + + Q L+Q LE+ E
Sbjct: 949 QRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1006
Query: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE---NMILQMREGQKKEIEIL----- 927
+ + ++++ + +L+ E ++ ++KE ++ E QK + E+
Sbjct: 1007 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1066
Query: 928 TQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
+LSA+ + + L E ++ + K+E+V+ + E LK L
Sbjct: 1067 VARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1126
Query: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------KEQIESLTEV 1035
E A E KE Q L +A A + ++ E Q ++++ EV
Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1186
Query: 1036 HRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
R E + + W +++ Q E Q + Q +++E+ +L +++ + +E
Sbjct: 1187 GERLQQRHGERDVEVERWRERVAQLLERWQAV-LAQTDVRQRELEQLGRQLRYY---RES 1242
Query: 1090 MNKEITWLKEEGVKQD-------TTLNELQEQLKQKSA---------------------H 1121
+ WL++ +Q+ ++EQL+Q+ A +
Sbjct: 1243 ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY 1302
Query: 1122 VNSLAQDETKL---KAHLE---------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
+N++ E +L KA LE K++ ++E L+ EL L + +
Sbjct: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362
Query: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
+SE +++ + + ++ + +E + ++L+E A ++ + L +
Sbjct: 1363 FISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQ-------- 1280
E++ + +A Q + ++E L ++ + +E++A+ RQ
Sbjct: 1423 RMQEEVVRREEAAVDA--------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 1281 --LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
+ EE + + + Q E ++++++A E +K Q+E ++ ++
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 1339 SCITQLKKELSENINAVTLMKEE-------LKEKKVEISSLSKQLTDLNV----QLQNSI 1387
Q + EL+ + A E L+E +++ ++L V Q+Q ++
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
Query: 1388 SLSEK--EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
+++ EA + S R + E+ +L +Q+ V L +E +Q + + + E
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREE 1653
Query: 1446 KKKAQSRFTQHQNTVKELQIQLE-------------LKSKEAYEKD------------EQ 1480
++ R+ N L++Q E K KE E++ Q
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 1481 INLLKEELDQQNK-----------------RFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
L ++EL++Q + R + E + +E++ + L+ E +
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA 1773
Query: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ----HFQELGEEKDN- 1578
T + ELE + + E+E L ++ ++ Q+L+ F+EL EE
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1833
Query: 1579 --RVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSK-EEELKALEDRLESESA 1634
+EA+ + E +AE E ++L + + + K E E+ E E+E
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
+LAE + +++ Q + +EE+ Q +K ++S L ER+ ++E+
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL----------ERQKGLVEDT 1943
Query: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI---------SVLQRNL 1745
L+ + E L + S + AA + E + G ++ E+ + + QR L
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELE-LGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 1746 TEKEKLLQRVGQEK-EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
+E+ +R +E+ ++++++ E Q + L ++E +AK E + L+E E++
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR----RLRERAEQE 2058
Query: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQN-----LENVFDDVQKTLQEKELTCQILEQKIKEL 1859
+ + L +AQ E + +QA++ ++ ++Q+TLQ+++ +L+Q E
Sbjct: 2059 SAR-QLQLAQ----EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ---SVLDQLRGEA 2110
Query: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
++ ++ E + ++ E Q+ +Q++ + + EE + ++++ KL
Sbjct: 2111 EAA---RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
E + A R+KQ E+ + +K + LR++ Q QEL L+ + ++
Sbjct: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2227
Query: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETINKAQEVEAE---L 2030
+K ++E LK +T E Q +Q E+EL + ++E +EAE L
Sbjct: 2228 QKNLLDEELQRLKAEAT------EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
+ ++ T + L++ AEK +K+ A+ + A +E A++R L + Q+ +
Sbjct: 2282 ILRDKDNTQRFLQEEAEK---MKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAE 2336
Query: 2091 KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFREQI-HNLEDRLKKYEKNVY 2148
K+ +E+ T ++ + +L Q+ ++ + + QE +EQ+ L + + +++ +
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2396
Query: 2149 A 2149
A
Sbjct: 2397 A 2397
Score = 48.5 bits (114), Expect = 7e-05
Identities = 210/1197 (17%), Positives = 473/1197 (39%), Gaps = 197/1197 (16%)
Query: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
+++E K + E ++QL+ + + L + TKL+ E LN++ + LQ
Sbjct: 393 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA---DALLQSD 449
Query: 1157 LV-----ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
+ ++ A E +R + + S ++ + Q+LK + + + +L E
Sbjct: 450 VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY---RLHE 506
Query: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
L +TE L K +++ T + Q R ++ T+
Sbjct: 507 RLV------AIRTEYNLRLKAG----VAAPATQVAQVTLQSVQRRPE-------LEDSTL 549
Query: 1272 SELEAQLRQLTEEQNTLN-ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
L+ L + E Q+ ++ + +E + + + IE + E + + G
Sbjct: 550 RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQL 609
Query: 1331 QQAA-SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-- 1387
A C+ +L + ++ +N+ L+ +++ +K+L LN + + +
Sbjct: 610 SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGF 669
Query: 1388 -------SLSEKEAAISSLRKQYD--EEKCELLDQVQDLSFKVDTLSKEKISALEQV--D 1436
+++ K+ + S+L ++ + E+K + L D + D ++ + + +
Sbjct: 670 DWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT 729
Query: 1437 DWSNKFS-----EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
WS E K + + Q + V+E + QL+ K +EA + K D+
Sbjct: 730 QWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ-KLQEALRR-------KYSCDRS 781
Query: 1492 NK--RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
R + L + +D+K ++ + + +L + L + +++L+ + +
Sbjct: 782 ATVTRLEDLLQDAQDEKEQLNEYKGHL-SGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 840
Query: 1550 NYNQQKDIEHK----ELVQKLQ--HFQELG----------------------EEKDNRVK 1581
+Y Q + HK +LV Q H++ L +E R++
Sbjct: 841 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 900
Query: 1582 EAEEKILTLENQVY-SMKAEL--ETKKKELEHVN---------LSVKSKEEELKALEDRL 1629
+ ++TL +Q++ MK+ L ++ +++++ + L + + + L +LE
Sbjct: 901 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 960
Query: 1630 E-----SESAAKLA-ELKRKAEQKIAAIK---KQLLSQMEE--KEEQYKKGTESHLSELN 1678
+ S+ A E + AE++ + +QLL +E+ +EE + S L ++
Sbjct: 961 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1020
Query: 1679 TKLQERE-REVHILE------------EKLKSVESSQSETLIVPRSAKNVAAYTEQ---- 1721
+L+ E R VH L +++ + +Q+E + + ++A E+
Sbjct: 1021 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1080
Query: 1722 -EEADSQGCVQKTYE------EKISVLQRNLTEKEK---LLQRVGQEKEETVSSHFEMRC 1771
E + + ++ E E++ L EK K L+ R Q EE + +H E
Sbjct: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1140
Query: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI---------VAQHVEKEGGK 1822
+ Q L EA + + + L+ + E + + + V + +++ G+
Sbjct: 1141 EAQAVPATLPELEATK----ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 1823 NNIQAKQNLENV---FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
+++ ++ E V + Q L + ++ + LEQ L RQ +R + L +
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ--------LGRQLRYYRESADPLGA 1248
Query: 1880 -------KYEKLQALQQMDGRNKPTELLEENTE-EKSKSHLVQPKLLSNMEAQH----ND 1927
+ E++QA+ D + +L +E E+ + H + + Q+ D
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1308
Query: 1928 LEFKL-----------AGAEREKQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
E +L + A++ K + G E +++ DLR H EL L +Y +
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRT----HYSELTTLTSQYIKFI 1364
Query: 1976 EEKIKQEQEDLELKHNSTLKQLMREFNTQLA-QKEQELEMTIKETINKAQEVEAELLESH 2034
E +++ +E+ L ++ R + A +K+++L + +A+ EL +
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT------QLEELQKKY 2088
QEE + + + + + +++ + E E+ AK R + ++EE +
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
Query: 2089 QQKLEQEENP-GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
+ +LE E G + L+ + + ++ + + R Q+ + R ++ E
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 209 bits (533), Expect = 2e-53
Identities = 422/1981 (21%), Positives = 815/1981 (41%), Gaps = 343/1981 (17%)
Query: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425
RQ+ L M+ + + R+ T R + +E+ L T Q+
Sbjct: 262 RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 321
Query: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481
++E + L +D I E T ++L+ EL K + S + +I L
Sbjct: 322 SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 376
Query: 482 -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539
Q + EKE R + + +KL++ + A+E+ L+ E+ ++ AL+ E
Sbjct: 377 DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 436
Query: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
L +++ IL ++ + +L+QE E +T + L SL+EN +L + AEK
Sbjct: 437 LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 494
Query: 600 KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
+ +T ++++ + + K + L E+L ++ +Y+ + L+++ ++
Sbjct: 495 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 553
Query: 653 KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710
Q+ +EE + + +L +K + E + + S ++ H L EE + L
Sbjct: 554 -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 601
Query: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
M E E +++ K H + + + E E ++ EK L + + + +E K
Sbjct: 602 -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 655
Query: 771 HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
E++ H +E +D+K ELQ +A L + A HE T +EE+ QLQ KL
Sbjct: 656 QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 709
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889
+ +T L K + E + K T+ A + ++ +Q ++ E+KV+ LTQ E
Sbjct: 710 EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQELE 763
Query: 890 --------SKLEDGNKEQEQTKQILVEKENMILQM-REGQKKEIEILTQKLSAK------ 934
S +E E+E+ ++ L+EK LQ RE + E T ++ A+
Sbjct: 764 QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQ 823
Query: 935 ------EDSIHILNEEYETKFKN-QEKKME----------KVKQKAKEMQETLKKKL-LD 976
E ++ L Y + K+ QE++ E ++ Q+ E QE LK+ L +
Sbjct: 824 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 977 QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ---KEQIESLT 1033
+ L E LE + KE N+ ++E Q + D + ET Q +QI L
Sbjct: 884 KTTSLVLTQEREMLEKTYKE-HLNSMVVERQQL-LQDLEDLRNVSETQQSLLSDQILELK 941
Query: 1034 EVHRRELNDVISIW------EKKLNQQAEELQEIHEIQLQE------------------K 1069
H+REL + + E+ +Q+ E L+ H+ + QE
Sbjct: 942 SSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETA 1001
Query: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLK----------EEGVKQDTTLNELQ--EQLKQ 1117
++E AE+ +I + +EM + + L EE V+ D L+ LQ EQL +
Sbjct: 1002 DRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLE 1061
Query: 1118 KSAHV---------------NSLAQDETKLKAHLEKLEVDL---------------NKSL 1147
++ V +A + ++L+ L+KLE L N +
Sbjct: 1062 ENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1121
Query: 1148 KENTFLQ-------EQLVELKMLAEEDKRKVSEL----TSKLKTTDEEFQSLKSSHE--- 1193
+ FLQ E + +L++ + +V +L TS ++ + + + ++S E
Sbjct: 1122 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
Query: 1194 --KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN-AILSRI 1250
++++ +S E K +L QL + C + E K + L ++S K +L RI
Sbjct: 1182 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1241
Query: 1251 SHCQHR----------------------TTKVKEALLIK---TCTVSELEAQLRQLTEEQ 1285
+ T+ EAL T V L+ +L+++ E
Sbjct: 1242 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1301
Query: 1286 NT---LNISFQQATHQLEEKENQIKSMKADIESL---VTEK----------EALQKE-GG 1328
T L S+ + + EE + ++ IE L V ++ E L+ E G
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
Query: 1329 NQQQAASEKESCITQLK---------KELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
N Q E C+ +++ K+ ++ + T + E++K ++ + Q
Sbjct: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1421
Query: 1380 NVQLQNSISLSEKEAAISSLRKQYDE---------EKCELLDQVQDLSFKVDTLSKEKIS 1430
++QN + L E + K + EK +L + + L +V L K+K
Sbjct: 1422 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK-- 1479
Query: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488
+ S +K+ + + H Q T E+Q ++EL E+ + ++ ++L+ E+
Sbjct: 1480 ---------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1530
Query: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE-IESLNEV 1547
N+ ED S ++ N E Q ++ E+ QK +E ++
Sbjct: 1531 TTLNE---------EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
Query: 1548 LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKE 1607
LK NQQ D+E+ EL QK QE +E + R+ E + + + + LE +++E
Sbjct: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE-----MLCQKEKEPGNSALEEREQE 1636
Query: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
++K + E K L S A+L+E+ K + I + LL EK +Q
Sbjct: 1637 ----KFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDELEKMKQLH 1690
Query: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL--IVPRSAKNVAAYTEQEEAD 1725
+ + LS+ K+ V EKL + + SE L V + AK+ +
Sbjct: 1691 RCPD--LSDFQQKIS----SVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL---EHRIA 1741
Query: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS-HFEMRCQYQERLIKLEHAE 1784
+ QK++E + + L+ L ++ +Q + E+TV + + +M + + + E
Sbjct: 1742 TMKQEQKSWEHQSASLKSQLVASQEKVQNL----EDTVQNVNLQMSRMKSDLRVTQQEKE 1797
Query: 1785 AKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
A + E S+ LQ K ++ +A H G +N Q + + +D + + E
Sbjct: 1798 ALKQEVMSLHKQLQ---NAGGKSWAPEIATH---PSGLHNQQKRLS----WDKLDHLMNE 1847
Query: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
++ Q+L Q+ + L + + K ELT EK++ LE N
Sbjct: 1848 EQ---QLLWQENERLQTMVQNTK-------AELTHSREKVRQ-------------LESNL 1884
Query: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
K + HL ++ E + L+ + ++E+ +++ ++ +QEL
Sbjct: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQM--------NSLEQEL 1936
Query: 1965 EILKKEYDQEREEKIKQEQEDLELKH---NSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
E + E + +++++K +++ +E++H +T ++ QL Q +Q M +E
Sbjct: 1937 ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ-QQACPMVPREQFL 1995
Query: 2022 KAQE--VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT 2079
+ Q ++AE + H +E ++ + + E+++ EE M + L+
Sbjct: 1996 QLQRQLLQAERINQHLQE------ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKL 2049
Query: 2080 QLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
LQ+K Q EQ + + +L + AQ + ++ +++ ++ + LE++
Sbjct: 2050 VKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEK 2109
Query: 2140 L 2140
+
Sbjct: 2110 I 2110
Score = 205 bits (521), Expect = 5e-52
Identities = 393/1919 (20%), Positives = 806/1919 (42%), Gaps = 338/1919 (17%)
Query: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
+L E L+ + + +L+S++ + L+ + REK+KL+ L +++ +E+
Sbjct: 345 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 404
Query: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250
+ ++ ++ + D EE + I+ L+ ++ ++++ + G +++ + + +
Sbjct: 405 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 461
Query: 251 LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303
+ + + +EN + E ++E+ + E L +++R EN+L +
Sbjct: 462 AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
Query: 304 S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352
+E+ T + +E E LQ+Q+DE ELE+ + A+ L L+++
Sbjct: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 576
Query: 353 NLIEQLEQDKG-----------------------MVIAETKRQMHET-----LEMKEEEI 384
+ E++E + G +VI + K Q H LE+ E+++
Sbjct: 577 S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL-EDKV 633
Query: 385 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST-----------AQKTEEARRKL 433
++ + ++ +E ++ LEK +S A +EA +
Sbjct: 634 RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 693
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
+E+ K ++ EEE+ LQ+ KL+ HE EL +
Sbjct: 694 TCRHEEEKKQLQVKLEEEKTHLQE----------------------KLRLQHEMELKARL 731
Query: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE-SE 552
+ + RERE + EK + ++ Q ++Q + +E+ L+K+ + E E
Sbjct: 732 TQAQASFE-REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 790
Query: 553 NKLRDLQQEAETYRTRILELESSLEKSLQEN-KNQSKDLAVHLEAEKNKHNKEITVMVEK 611
R+LQ+ E T S +E Q + + ++ L++ + ++ +E+
Sbjct: 791 KHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQEL------ 844
Query: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET---LLKDKEIIFQAHI 668
+L+ + ++ + W + L Q+ E L+E ++EK T L +++E++ + +
Sbjct: 845 --KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 902
Query: 669 EEMNEKTLEKLDVKQTELESLS--SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
E +N +E+ + Q +LE L SE + L + LE + S ++ ++ + +A
Sbjct: 903 EHLNSMVVERQQLLQ-DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGAS 961
Query: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
EQ Q+++ + EH+ Q L N + + D+ E + L++ I
Sbjct: 962 EQL--ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKI 1019
Query: 787 KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ--KLLDLETERILLTKQVAE 844
K E+QQA++ L + QS E+ + L+ LQQ +LL+ E +LL+ Q A
Sbjct: 1020 K----EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLE-ENGDVLLSLQRAH 1074
Query: 845 VEAQKKDV--CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK--EQE 900
+A K++V TE+ ++Q +Q+LE + T+ + + E +Q
Sbjct: 1075 EQAVKENVKMATEIS----RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1130
Query: 901 QTKQIL-VEKENMILQMREGQKKEI-----------EILTQKLSAKEDSIHILNEEYETK 948
+TKQ+ V + +++ + + + +++ E+ ++ A + L ET+
Sbjct: 1131 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1190
Query: 949 FKNQEKKMEKVKQKAKEMQETL-------------KKKLLDQEAKLKKELENTALELSQK 995
++ E +K + ++QE L K+ LL + LKK+L+ + +
Sbjct: 1191 TESWE-----LKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEA 1244
Query: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIES----LTEVHR--------RELNDV 1043
++ ++++ N + + + +ET E +E+ EV R E+ +
Sbjct: 1245 SPKYKLLYEDVSRENDC-LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTET 1303
Query: 1044 ISIWEKKLNQQAEELQEIHEIQLQ-----EKEQEVAELKQKILLFGCEKEEMNKE----- 1093
EK ++ E +E++ + L+ EK QE + L+ E + E
Sbjct: 1304 FLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1363
Query: 1094 --ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA------------HLEKL 1139
+ EE V + +++ + E+ KQ++ ++ Q K+KA H E+
Sbjct: 1364 LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP 1423
Query: 1140 EVDLNKSLKENTFL----------QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
V L+ENT L Q + EL++ +K K+ ELT KLK E L
Sbjct: 1424 RVQNQVILEENTTLLGFQDKHFQHQATIAELEL----EKTKLQELTRKLK---ERVTILV 1476
Query: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249
+K S +K E K + +L I +K E LL ++ +L +S N I
Sbjct: 1477 K--QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVE-LLRYESEKLQQENSILRNEI--- 1530
Query: 1250 ISHCQHRTTKVKEALL--IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEK--ENQ 1305
TT +E + +K T++ + ++ Q TE N + Q+ L+++ E +
Sbjct: 1531 -------TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK 1583
Query: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE---- 1361
IK+ + D+E+ E QK NQ++ +EL++ + + KE+
Sbjct: 1584 IKNQQLDLEN----TELSQKNSQNQEKL------------QELNQRLTEMLCQKEKEPGN 1627
Query: 1362 --LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419
L+E++ E +L ++L VQ +SSL + E K + Q+
Sbjct: 1628 SALEEREQEKFNLKEELERCKVQ---------SSTLVSSLEAELSEVKIQTHIVQQENHL 1678
Query: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479
D L EK+ L + D S++++K S + ++ +KE KEA E
Sbjct: 1679 LKDEL--EKMKQLHRCPD----LSDFQQKISSVLSYNEKLLKE---------KEAL--SE 1721
Query: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539
++N ++L ++ + M+ ++ E + ++L+++L + ++ LED + +
Sbjct: 1722 ELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL 1780
Query: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE-----------------------EK 1576
++ + L+ Q+K+ +E++ + Q G +K
Sbjct: 1781 QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDK 1840
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
+ + E+++L EN+ ++ ++ K EL H V+ E L + + S
Sbjct: 1841 LDHLMNEEQQLLWQENE--RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT- 1897
Query: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
EQ+ ++K++ +E+ +K +S++N+ QE E +H+ E LK
Sbjct: 1898 ----MNPTEQEKLSLKRECDQFQKEQSPANRK-----VSQMNSLEQELE-TIHLENEGLK 1947
Query: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEA------DSQGCVQKTYEEKISVLQRNLTEKEK 1750
+ E L+ + ++ A + A Q C E+ + LQR L + E+
Sbjct: 1948 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ-LQRQLLQAER 2006
Query: 1751 LLQRVGQEKEETVS-------SHFEMRCQYQERLIKLEH-AEAKQHEDQSMIGHLQEELE 1802
+ Q + +E E S + ++ +ER+I++E + + Q + L+E+L
Sbjct: 2007 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLC 2066
Query: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
+ K +++ +VE N Q + LE V + QKT ++K +LE+KI L +
Sbjct: 2067 KNTKADAMVKDLYVE------NAQLLKALE-VTEQRQKTAEKKN---YLLEEKIASLSN 2115
Score = 169 bits (427), Expect = 4e-41
Identities = 339/1583 (21%), Positives = 663/1583 (41%), Gaps = 246/1583 (15%)
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILS 179
E ED V + + E ++ + E + + L L+ E +LQG +L
Sbjct: 628 ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLK 687
Query: 180 QSQDKSLRRIAELREELQMD-QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR--LR 236
++ ++ R E +++LQ+ ++ K HLQE+ E + + Q Q S ++R L+
Sbjct: 688 EAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQ 746
Query: 237 NGPMNVDVLKPLPQL---------------------EPQAEVFTKEENPESDGEPVVEDG 275
+ + ++ L Q E + E+ K + +G +E
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
Query: 276 TSVKTLETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTS----EKEALQEQLDERL 327
+ +T + Q + + +RC+ +QS ++++ L EK + + DE
Sbjct: 807 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
Query: 328 QEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE-- 381
QE E +K+ EKT + ++ + L + ++ ++ E ++ + + +++
Sbjct: 867 QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 926
Query: 382 --------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LSTAQKTEEARRK 432
++I +L+S K+ + EE+ Q SE+ A + LE+ + Q+ +E K
Sbjct: 927 ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 986
Query: 433 LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------EEQI- 478
L A M+ K +T++ ER + E+SR++ ++ ++ + +S EE++
Sbjct: 987 LLA-MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
Query: 479 ----AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
L + E+ L L + E+ +E +K+A E S+ + E S
Sbjct: 1046 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1105
Query: 535 LALEELELQKKAILTESENKL----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
L+E + E R Q E T R + +LE + L S
Sbjct: 1106 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSS--- 1162
Query: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
++ + E + + +ELE+ + + W K Q+ Q Q ++ L C+
Sbjct: 1163 -----VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI--SQLQEQLMMLCADCD 1215
Query: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKL------------------DVKQTELESLSSE 692
+ E K ++++F + + K LE++ D Q EL + +
Sbjct: 1216 RASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1272
Query: 693 LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS-------------I 739
E L+ +L E+ L+D+ KM++ E + +K++ + ++++ I
Sbjct: 1273 YDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1332
Query: 740 IKEHEVSIQRTEKALKD------------QINQLELLLKERDKHLKEHQAHVENLEADIK 787
K E +QR + L + I QL L+E ++ +E + + +
Sbjct: 1333 EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ 1392
Query: 788 RSEGELQ--------QASAKLDVFQSYQSATHEQTK----------AYEEQLAQLQQKLL 829
EG Q + + Q++Q Q + ++++ Q Q +
Sbjct: 1393 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
Query: 830 DLETERILL------TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
+LE E+ L K+ + ++KDV + + + +++ +M L+ SEM+QKV+
Sbjct: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE-ELKAMMHDLQITCSEMQQKVEL 1511
Query: 884 LTQVYES-KLEDGNKEQEQTKQILVEKE---NMILQMREGQKKEI----EILTQKLSAKE 935
L YES KL+ N L E++ N+ L G ++E+ E + Q+ +A +
Sbjct: 1512 LR--YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
Query: 936 DSIHILNEEY-ETKFKNQEKKME--KVKQKAKEMQETLK---KKLLDQEAKLKKELENTA 989
+ L ++ E K KNQ+ +E ++ QK + QE L+ ++L + + +KE N+A
Sbjct: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1629
Query: 990 LELSQKEKQFNAK-MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
LE ++EK FN K LE + S S VS LE E ++ T + ++E
Sbjct: 1630 LEEREQEK-FNLKEELERCKVQS---STLVSSLEAELSE-VKIQTHIVQQE--------N 1676
Query: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
L + E+++++H ++++ +QKI E++ KE L EE L
Sbjct: 1677 HLLKDELEKMKQLHRC------PDLSDFQQKISSVLSYNEKLLKEKEALSEE-------L 1723
Query: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
N ++L + S + +A + + K+ E L L + QE++ L+ +
Sbjct: 1724 NSCVDKLAKSSLLEHRIATMKQEQKS-WEHQSASLKSQLVAS---QEKVQNLEDTVQNVN 1779
Query: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
++S + S L+ T +E ++LK +K L++ K + E+A + + L
Sbjct: 1780 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLS 1837
Query: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
K + L+N + + Q K L V +LE+ L L + Q L
Sbjct: 1838 WDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL--LPKHQKHL 1892
Query: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
N S T E+E SL E + QKE Q A+ K S + L++EL
Sbjct: 1893 NPS---GTMNPTEQEKL---------SLKRECDQFQKE----QSPANRKVSQMNSLEQEL 1936
Query: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
+ L E LK+K+V+ L +QL ++ L+++ + S A Q ++ C
Sbjct: 1937 ----ETIHLENEGLKKKQVK---LDEQLMEMQ-HLRSTATPSPSPHAWDLQLLQ--QQAC 1986
Query: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
++ + Q L + L E+I+ Q ++ N+ SE Q Q ++E I++E
Sbjct: 1987 PMVPREQFLQLQRQLLQAERINQHLQ-EELENRTSE-TNTPQGNQEQLVTVMEERMIEVE 2044
Query: 1469 LKSKEAYE-KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI 1527
K K E++N LKE+L +N + D + ++ + +++ K E+ Q +
Sbjct: 2045 QKLKLVKRLLQEKVNQLKEQL-CKNTKADAMVKDLYVENAQLLK-----ALEVTEQRQKT 2098
Query: 1528 MELEDHITQKTIEIESLNEVLKN 1550
E ++++ ++ +I SL+ +++N
Sbjct: 2099 AEKKNYLLEE--KIASLSNIVRN 2119
Score = 152 bits (383), Expect = 5e-36
Identities = 342/1581 (21%), Positives = 646/1581 (40%), Gaps = 296/1581 (18%)
Query: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
E I EE E + E L L+ + L+E+ A LE EL V K+ + Q
Sbjct: 308 ERILDTWQEEGIENSQEILKALDFSLDG-NINLTELTLA---LENELLVTKNS---IHQA 360
Query: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
A + H ++VD +++E E L+ +++ E L + +H A +E
Sbjct: 361 ALASFKAEIRHLLERVDQVVREKE--------KLRSDLDKAEKLKSLMASEVDDHHAAIE 412
Query: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT- 839
+R+E L+ KLD + Y+E++A L+ +L E E+IL
Sbjct: 413 ------RRNEYNLR----KLD-------------EEYKERIAALKNELRK-EREQILQQA 448
Query: 840 -KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898
KQ E+E + + TE + ++D + K+NS +E ++ LE+ K
Sbjct: 449 GKQRLELEQEIEKAKTEEN----YIRDRLALSLKENSRLENEL----------LENAEK- 493
Query: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI--HILNEEYETKFKNQEKKM 956
L E EN+ ++ Q+ +L +K + S L EE T+ +N+ ++
Sbjct: 494 -------LAEYENLTNKL---QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 543
Query: 957 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI-- 1014
+V Q DQ +L+ ELE + E +ANS GI
Sbjct: 544 CRVLQ--------------DQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 589
Query: 1015 -----SDAVSRLETNQKEQ--IESLTEVHRR-------ELNDVISIWEKKLNQQAEELQE 1060
S+ + L + + + IE + E H R EL D + +EK+L++ ++
Sbjct: 590 EHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKK 649
Query: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120
E Q E E L+++I E E+ + LKE + E ++QL+ K
Sbjct: 650 AQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
Query: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180
+ Q++ +L+ E++L L + E+ E + + KV LT
Sbjct: 710 EEKTHLQEKLRLQH-----EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLT----- 759
Query: 1181 TDEEFQSLKSSHEKSNKSLEDK-SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Q L+ H++ SL +K +LE ++L +EL +K + L+ ++
Sbjct: 760 -----QELEQFHQEQLTSLVEKHTLEKEELRKELL-------EKHQRELQEGREKMETEC 807
Query: 1240 SSKTNAILSRI-SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
+ +T+ I ++ S CQ T + + AL LE + RQ E L ++ Q
Sbjct: 808 NRRTSQIEAQFQSDCQKVTERCESAL-------QSLEGRYRQ---ELKDLQEQQREEKSQ 857
Query: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
E +++++ A+ + L+ KE L++E E+E L+K E++N++ +
Sbjct: 858 WEFEKDELTQECAEAQELL--KETLKREKTTSLVLTQERE----MLEKTYKEHLNSMVVE 911
Query: 1359 KEELKEKKVEISSLSKQ----LTDLNVQLQNSIS--LSEKEAAI--SSLRKQYDEEKCEL 1410
+++L + ++ ++S+ L+D ++L++S L E+E + + +Q ++ E
Sbjct: 912 RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 971
Query: 1411 LD-----QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL-- 1463
L+ + Q++ K+ + + E D + S + QS+ + Q L
Sbjct: 972 LEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM 1031
Query: 1464 -QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Q ++ +E E D ++LL++ + D L ++ + K+ + TE+
Sbjct: 1032 LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS-LQRAHEQAVKENVKMATEISR 1090
Query: 1523 QTARIMELEDHITQKTIEIESLNEVLKN----------YNQQKDIE---HKELVQKLQ-- 1567
R+ +LE + + E E N N+ K +E + ++ L+
Sbjct: 1091 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
Query: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
++LG + V+ E KI E V +ELE ++ +++ ELK
Sbjct: 1151 EVRDLGSTGTSSVQRQEVKIEESEASVEGF-SELENSEE--------TRTESWELKNQIS 1201
Query: 1628 RLESESAAKLAELKRKAEQK------IAAIKKQL--LSQMEEKEEQYKKGTESHLSELNT 1679
+L+ + A+ R +E+K ++ +KK+L L ++ E +YK
Sbjct: 1202 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYK-----------L 1250
Query: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
++ RE L+E+L+ +E+ E L +N
Sbjct: 1251 LYEDVSRENDCLQEELRMMETRYDEAL------EN------------------------- 1279
Query: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
+ LT + LQ ++ EE + + Y E I+ E Q I LQE
Sbjct: 1280 --NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1337
Query: 1800 ELEEKNK----KYSLIVAQHVEKEGGKNNIQAKQNLE----------NVFDDVQKTLQEK 1845
+ ++ + SL +++E E N +Q Q LE +V ++ ++ Q
Sbjct: 1338 SVVQRCDCCLWEASL---ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL 1394
Query: 1846 ELTCQILEQ----KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
E Q+LE+ +I L + +E RV+ + + + L Q +++ T +
Sbjct: 1395 EGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQAT--IA 1452
Query: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
E EK+K + KL + + G + E E+ + DL++ E Q
Sbjct: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE------ELKAMMHDLQITCSEMQ 1506
Query: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Q++E+L+ E EK++QE NS L+ + N +E + T+N
Sbjct: 1507 QKVELLRYE-----SEKLQQE--------NSILRNEITTLN-----EEDSISNLKLGTLN 1548
Query: 2022 KAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL 2081
+QE + E+ ++E N ++K+ E K + LD E++ K Q +L
Sbjct: 1549 GSQEEMWQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL 1607
Query: 2082 EELQKKYQQKL-EQEENPGNDNVTIM---------ELQTQLAQKTTLI-------SDSKL 2124
+EL ++ + L ++E+ PGN + EL+ Q +TL+ S+ K+
Sbjct: 1608 QELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI 1667
Query: 2125 KEQEFREQIHNLEDRLKKYEK 2145
+ +++ H L+D L+K ++
Sbjct: 1668 QTHIVQQENHLLKDELEKMKQ 1688
Score = 122 bits (306), Expect = 4e-27
Identities = 274/1377 (19%), Positives = 551/1377 (40%), Gaps = 214/1377 (15%)
Query: 890 SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF 949
S L+DG + + +E I +E K L ++ E ++ + NE TK
Sbjct: 296 SCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKN 355
Query: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA 1009
+ + K + + + E + + + ++E KL+ +L+ S + + + +
Sbjct: 356 SIHQAALASFKAEIRHLLERVDQVVREKE-KLRSDLDKAEKLKSLMASEVDDHHAAIERR 414
Query: 1010 NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
N + +L+ KE+I +L R+E ++ QQA + + E ++++
Sbjct: 415 NEYNLR----KLDEEYKERIAALKNELRKEREQIL--------QQAGKQRLELEQEIEKA 462
Query: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH-VNSLAQD 1128
+ E ++ ++ L E + E+ E+ + + N+LQ L+ A L
Sbjct: 463 KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 522
Query: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE---- 1184
+ E+L N+ ++ LQ+Q+ EL+ EE + + L LK + E
Sbjct: 523 SAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEA 582
Query: 1185 ----------------------------FQSLKSSHEKS----NKSLEDKSLEFKKLSEE 1212
+ +K H + LEDK ++K +E
Sbjct: 583 NSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDE 642
Query: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
+ CKK + ++ + + + + + + I+ Q + +KEA TC
Sbjct: 643 TVVS----CKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
E + QL+ EE+ T + H++E K ++ S E+E LQ +++
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA----SFEREREGLQSSAWTEEK 754
Query: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEI-------------SSLSKQLTDL 1379
+ +++L+ + TL KEEL+++ +E + +++ + +
Sbjct: 755 VRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQI 814
Query: 1380 NVQLQNSIS-LSEK-EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Q Q+ ++E+ E+A+ SL +Y +E +L +Q ++ EK + D+
Sbjct: 815 EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE----------EKSQWEFEKDE 864
Query: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
+ + +E ++ + + + T L + E+ K Y+ E +N + E Q
Sbjct: 865 LTQECAEAQELLKETLKREKTTSLVLTQEREMLEK-TYK--EHLNSMVVERQQ------- 914
Query: 1498 LKGEMEDDKSKMEKKESNLET---ELKSQTAR-IMELEDHITQKTIEIESLNEVLKNYNQ 1553
L ++ED ++ E ++S L ELKS R + E E+ + Q + ++ L+
Sbjct: 915 LLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 974
Query: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
+ D E +E++ KL + + + + A+ + + ++ + L++K KE++
Sbjct: 975 EHDQERQEMMSKLLAMENIHKAT---CETADRERAEMSTEI----SRLQSKIKEMQQATS 1027
Query: 1614 SVKSKEEELKAL-EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE- 1671
+ + + + E+ +E + A L + + EQ + LLS E+ K+ +
Sbjct: 1028 PLSMLQSGCQVIGEEEVEGDGALSLLQ---QGEQLLEENGDVLLSLQRAHEQAVKENVKM 1084
Query: 1672 -SHLSELNTKLQEREREVHI---LEEKLKSV---ESSQSETLIVPRSAKNVAAYTEQE-- 1722
+ +S L +LQ+ E + + L+E + Q+E + K V T +
Sbjct: 1085 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL 1144
Query: 1723 ---EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMR---CQYQ 1774
E D + T + + + E E ++ + EET + +E++ Q Q
Sbjct: 1145 SDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ 1204
Query: 1775 ERLIKL----EHAEAKQHE---DQSMIGH---LQEELEEKNKKYSLIVAQHVEKEGGKNN 1824
E+L+ L + A K+ + D S++ + E + E + KY L+ + V +E
Sbjct: 1205 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY-EDVSRENDCLQ 1263
Query: 1825 IQAKQNLENVFDDVQKTLQEKELTCQI--LEQKIKELDSC------LVRQKEVHRVEMEE 1876
+ + +E +D+ + KELT ++ L+ ++K+++ L + + ++E EE
Sbjct: 1264 EELRM-METRYDEALEN--NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1320
Query: 1877 LT-------SKYEKLQ--ALQQMDGRNKPTELLEENTEEKSKSHLVQ-PKLLSNMEAQHN 1926
L K EKLQ +Q+ D L EN E + +++Q + L +
Sbjct: 1321 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASL--ENLEIEPDGNILQLNQTLEECVPRVR 1378
Query: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
+ + ++E Q L + + ++L K E+ L +E Q Q L
Sbjct: 1379 SVHHVIEECKQENQYL-------EGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1431
Query: 1987 ELKHNSTLKQLM-REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
E N+TL + F Q E ELE T K QE+ +L E + +
Sbjct: 1432 E--ENTTLLGFQDKHFQHQATIAELELEKT------KLQELTRKLKER--------VTIL 1475
Query: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ------QKLEQEENPG 2099
++ D L K EEE+ A + DLQ E+Q+K + +KL+QE +
Sbjct: 1476 VKQKDVLSHGEK---------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSIL 1526
Query: 2100 NDNVTIME---------------LQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
+ +T + Q ++ QKT + Q+ E + LK
Sbjct: 1527 RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK 1583
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 209 bits (531), Expect = 3e-53
Identities = 419/1941 (21%), Positives = 797/1941 (41%), Gaps = 343/1941 (17%)
Query: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK----- 425
RQ+ L M+ + + R+ T R + +E+ L T Q+
Sbjct: 268 RQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIEN 327
Query: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL---- 481
++E + L +D I E T ++L+ EL K + S + +I L
Sbjct: 328 SQEILKALDFSLDGNINLTELT-----LALENELLVTKNSIHQAALASFKAEIRHLLERV 382
Query: 482 -QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE-E 539
Q + EKE R + + +KL++ + A+E+ L+ E+ ++ AL+ E
Sbjct: 383 DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNE 442
Query: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
L +++ IL ++ + +L+QE E +T + L SL+EN +L + AEK
Sbjct: 443 LRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLEN--AEKL 500
Query: 600 KHNKEITVMVEKHKTELESLK-------HQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
+ +T ++++ + + K + L E+L ++ +Y+ + L+++ ++
Sbjct: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDE- 559
Query: 653 KETLLKDKEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEVLKARHKL-EEELSVL 710
Q+ +EE + + +L +K + E + + S ++ H L EE + L
Sbjct: 560 -----------LQSELEEYRAQGRVLRLPLKNSPSEEVEAN-SGGIEPEHGLGSEECNPL 607
Query: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
M E E +++ K H + + + E E ++ EK L + + + +E K
Sbjct: 608 -----NMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCK-KAQENMK 661
Query: 771 HLKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
E++ H +E +D+K ELQ +A L + A HE T +EE+ QLQ KL
Sbjct: 662 QRHENETHTLEKQISDLKNEIAELQGQAAVL------KEAHHEATCRHEEEKKQLQVKLE 715
Query: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889
+ +T L K + E + K T+ A + ++ +Q ++ E+KV+ LTQ E
Sbjct: 716 EEKTH--LQEKLRLQHEMELKARLTQAQASFEREREGLQ----SSAWTEEKVRGLTQELE 769
Query: 890 --------SKLEDGNKEQEQTKQILVEKENMILQM-REGQKKEIEILTQKLSAK------ 934
S +E E+E+ ++ L+EK LQ RE + E T ++ A+
Sbjct: 770 QFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQ 829
Query: 935 ------EDSIHILNEEYETKFKN-QEKKME----------KVKQKAKEMQETLKKKL-LD 976
E ++ L Y + K+ QE++ E ++ Q+ E QE LK+ L +
Sbjct: 830 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 889
Query: 977 QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ---KEQIESLT 1033
+ L E LE + KE N+ ++E Q + D + ET Q +QI L
Sbjct: 890 KTTSLVLTQEREMLEKTYKE-HLNSMVVERQQL-LQDLEDLRNVSETQQSLLSDQILELK 947
Query: 1034 EVHRRELNDVISIW------EKKLNQQAEELQEIHEIQLQE------------------K 1069
H+REL + + E+ +Q+ E L+ H+ + QE
Sbjct: 948 SSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETA 1007
Query: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLK----------EEGVKQDTTLNELQ--EQLKQ 1117
++E AE+ +I + +EM + + L EE V+ D L+ LQ EQL +
Sbjct: 1008 DRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLE 1067
Query: 1118 KSAHV---------------NSLAQDETKLKAHLEKLEVDL---------------NKSL 1147
++ V +A + ++L+ L+KLE L N +
Sbjct: 1068 ENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAE 1127
Query: 1148 KENTFLQ-------EQLVELKMLAEEDKRKVSEL----TSKLKTTDEEFQSLKSSHE--- 1193
+ FLQ E + +L++ + +V +L TS ++ + + + ++S E
Sbjct: 1128 QTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
Query: 1194 --KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTN-AILSRI 1250
++++ +S E K +L QL + C + E K + L ++S K +L RI
Sbjct: 1188 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1247
Query: 1251 SHCQHR----------------------TTKVKEALLIK---TCTVSELEAQLRQLTEEQ 1285
+ T+ EAL T V L+ +L+++ E
Sbjct: 1248 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVT 1307
Query: 1286 NT---LNISFQQATHQLEEKENQIKSMKADIESL---VTEK----------EALQKE-GG 1328
T L S+ + + EE + ++ IE L V ++ E L+ E G
Sbjct: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
Query: 1329 NQQQAASEKESCITQLK---------KELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
N Q E C+ +++ K+ ++ + T + E++K ++ + Q
Sbjct: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQE 1427
Query: 1380 NVQLQNSISLSEKEAAISSLRKQYDE---------EKCELLDQVQDLSFKVDTLSKEKIS 1430
++QN + L E + K + EK +L + + L +V L K+K
Sbjct: 1428 RPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK-- 1485
Query: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488
+ S +K+ + + H Q T E+Q ++EL E+ + ++ ++L+ E+
Sbjct: 1486 ---------DVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEI 1536
Query: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIE-IESLNEV 1547
N+ ED S ++ N E Q ++ E+ QK +E ++
Sbjct: 1537 TTLNE---------EDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
Query: 1548 LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKE 1607
LK NQQ D+E+ EL QK QE +E + R+ E + + + + LE +++E
Sbjct: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE-----MLCQKEKEPGNSALEEREQE 1642
Query: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
++K + E K L S A+L+E+ K + I + LL EK +Q
Sbjct: 1643 ----KFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDELEKMKQLH 1696
Query: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL--IVPRSAKNVAAYTEQEEAD 1725
+ + LS+ K+ V EKL + + SE L V + AK+ +
Sbjct: 1697 RCPD--LSDFQQKIS----SVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL---EHRIA 1747
Query: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS-HFEMRCQYQERLIKLEHAE 1784
+ QK++E + + L+ L ++ +Q + E+TV + + +M + + + E
Sbjct: 1748 TMKQEQKSWEHQSASLKSQLVASQEKVQNL----EDTVQNVNLQMSRMKSDLRVTQQEKE 1803
Query: 1785 AKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
A + E S+ LQ K ++ +A H G +N Q + + +D + + E
Sbjct: 1804 ALKQEVMSLHKQLQ---NAGGKSWAPEIATH---PSGLHNQQKRLS----WDKLDHLMNE 1853
Query: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
++ Q+L Q+ + L + + K ELT EK++ LE N
Sbjct: 1854 EQ---QLLWQENERLQTMVQNTK-------AELTHSREKVRQ-------------LESNL 1890
Query: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
K + HL ++ E + L+ + ++E+ +++ ++ +QEL
Sbjct: 1891 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQM--------NSLEQEL 1942
Query: 1965 EILKKEYDQEREEKIKQEQEDLELKH---NSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
E + E + +++++K +++ +E++H +T ++ QL Q +Q M +E
Sbjct: 1943 ETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQ-QQACPMVPREQFL 2001
Query: 2022 KAQE--VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT 2079
+ Q ++AE + H +E ++ + + E+++ EE M + L+
Sbjct: 2002 QLQRQLLQAERINQHLQE------ELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKL 2055
Query: 2080 QLEELQKKYQQKLEQEENPGN 2100
LQ+K Q EQ PG+
Sbjct: 2056 VKRLLQEKVNQLKEQVSLPGH 2076
Score = 194 bits (494), Expect = 6e-49
Identities = 374/1861 (20%), Positives = 777/1861 (41%), Gaps = 321/1861 (17%)
Query: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192
+L E L+ + + +L+S++ + L+ + REK+KL+ L +++ +E+
Sbjct: 351 ALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEV 410
Query: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL--RNGPMNVDVLKPLPQ 250
+ ++ ++ + D EE + I+ L+ ++ ++++ + G +++ + + +
Sbjct: 411 DDHHAAIERRNEYNLRKLD---EEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEK 467
Query: 251 LEPQAE------VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQ-ENLLKRCKETIQ 303
+ + + +EN + E ++E+ + E L +++R EN+L +
Sbjct: 468 AKTEENYIRDRLALSLKENSRLENE-LLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 526
Query: 304 S-------HKEQCTLLTSEKE----ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352
+E+ T + +E E LQ+Q+DE ELE+ + A+ L L+++
Sbjct: 527 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR----AQGRVLRLPLKNSP 582
Query: 353 NLIEQLEQDKG-----------------------MVIAETKRQMHET-----LEMKEEEI 384
+ E++E + G +VI + K Q H LE+ E+++
Sbjct: 583 S--EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLEL-EDKV 639
Query: 385 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST-----------AQKTEEARRKL 433
++ + ++ +E ++ LEK +S A +EA +
Sbjct: 640 RHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEA 699
Query: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
+E+ K ++ EEE+ LQ+ KL+ HE EL +
Sbjct: 700 TCRHEEEKKQLQVKLEEEKTHLQE----------------------KLRLQHEMELKARL 737
Query: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE-SE 552
+ + RERE + EK + ++ Q ++Q + +E+ L+K+ + E E
Sbjct: 738 TQAQASFE-REREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLE 796
Query: 553 NKLRDLQQEAETYRTRILELESSLEKSLQEN-KNQSKDLAVHLEAEKNKHNKEITVMVEK 611
R+LQ+ E T S +E Q + + ++ L++ + ++ +E+
Sbjct: 797 KHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQEL------ 850
Query: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET---LLKDKEIIFQAHI 668
+L+ + ++ + W + L Q+ E L+E ++EK T L +++E++ + +
Sbjct: 851 --KDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 908
Query: 669 EEMNEKTLEKLDVKQTELESLS--SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
E +N +E+ + Q +LE L SE + L + LE + S ++ ++ + +A
Sbjct: 909 EHLNSMVVERQQLLQ-DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGAS 967
Query: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
EQ Q+++ + EH+ Q L N + + D+ E + L++ I
Sbjct: 968 EQL--ASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKI 1025
Query: 787 KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ--KLLDLETERILLTKQVAE 844
K E+QQA++ L + QS E+ + L+ LQQ +LL+ E +LL+ Q A
Sbjct: 1026 K----EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLE-ENGDVLLSLQRAH 1080
Query: 845 VEAQKKDV--CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK--EQE 900
+A K++V TE+ ++Q +Q+LE + T+ + + E +Q
Sbjct: 1081 EQAVKENVKMATEIS----RLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQN 1136
Query: 901 QTKQIL-VEKENMILQMREGQKKEI-----------EILTQKLSAKEDSIHILNEEYETK 948
+TKQ+ V + +++ + + + +++ E+ ++ A + L ET+
Sbjct: 1137 RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETR 1196
Query: 949 FKNQEKKMEKVKQKAKEMQETL-------------KKKLLDQEAKLKKELENTALELSQK 995
++ E +K + ++QE L K+ LL + LKK+L+ + +
Sbjct: 1197 TESWE-----LKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLE-RIPEA 1250
Query: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIES----LTEVHR--------RELNDV 1043
++ ++++ N + + + +ET E +E+ EV R E+ +
Sbjct: 1251 SPKYKLLYEDVSRENDC-LQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTET 1309
Query: 1044 ISIWEKKLNQQAEELQEIHEIQLQ-----EKEQEVAELKQKILLFGCEKEEMNKE----- 1093
EK ++ E +E++ + L+ EK QE + L+ E + E
Sbjct: 1310 FLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNI 1369
Query: 1094 --ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA------------HLEKL 1139
+ EE V + +++ + E+ KQ++ ++ Q K+KA H E+
Sbjct: 1370 LQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERP 1429
Query: 1140 EVDLNKSLKENTFL----------QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
V L+ENT L Q + EL++ +K K+ ELT KLK E L
Sbjct: 1430 RVQNQVILEENTTLLGFQDKHFQHQATIAELEL----EKTKLQELTRKLK---ERVTILV 1482
Query: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249
+K S +K E K + +L I +K E LL ++ +L +S N I
Sbjct: 1483 K--QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVE-LLRYESEKLQQENSILRNEI--- 1536
Query: 1250 ISHCQHRTTKVKEALL--IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEK--ENQ 1305
TT +E + +K T++ + ++ Q TE N + Q+ L+++ E +
Sbjct: 1537 -------TTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK 1589
Query: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE---- 1361
IK+ + D+E+ E QK NQ++ +EL++ + + KE+
Sbjct: 1590 IKNQQLDLEN----TELSQKNSQNQEKL------------QELNQRLTEMLCQKEKEPGN 1633
Query: 1362 --LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419
L+E++ E +L ++L VQ +SSL + E K + Q+
Sbjct: 1634 SALEEREQEKFNLKEELERCKVQ---------SSTLVSSLEAELSEVKIQTHIVQQENHL 1684
Query: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479
D L EK+ L + D S++++K S + ++ +KE KEA E
Sbjct: 1685 LKDEL--EKMKQLHRCPD----LSDFQQKISSVLSYNEKLLKE---------KEAL--SE 1727
Query: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539
++N ++L ++ + M+ ++ E + ++L+++L + ++ LED + +
Sbjct: 1728 ELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL 1786
Query: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE-----------------------EK 1576
++ + L+ Q+K+ +E++ + Q G +K
Sbjct: 1787 QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDK 1846
Query: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
+ + E+++L EN+ ++ ++ K EL H V+ E L + + S
Sbjct: 1847 LDHLMNEEQQLLWQENE--RLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT- 1903
Query: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
EQ+ ++K++ +E+ +K +S++N+ QE E +H+ E LK
Sbjct: 1904 ----MNPTEQEKLSLKRECDQFQKEQSPANRK-----VSQMNSLEQELE-TIHLENEGLK 1953
Query: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEA------DSQGCVQKTYEEKISVLQRNLTEKEK 1750
+ E L+ + ++ A + A Q C E+ + LQR L + E+
Sbjct: 1954 KKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQ-LQRQLLQAER 2012
Query: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH-LQEELEEKNKKYS 1809
+ Q + +E E S + ++ + +E + + ++ LQE++ + ++ S
Sbjct: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVS 2072
Query: 1810 L 1810
L
Sbjct: 2073 L 2073
Score = 162 bits (409), Expect = 4e-39
Identities = 328/1521 (21%), Positives = 631/1521 (41%), Gaps = 238/1521 (15%)
Query: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG---ILS 179
E ED V + + E ++ + E + + L L+ E +LQG +L
Sbjct: 634 ELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLK 693
Query: 180 QSQDKSLRRIAELREELQMD-QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR--LR 236
++ ++ R E +++LQ+ ++ K HLQE+ E + + Q Q S ++R L+
Sbjct: 694 EAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQ 752
Query: 237 NGPMNVDVLKPLPQL---------------------EPQAEVFTKEENPESDGEPVVEDG 275
+ + ++ L Q E + E+ K + +G +E
Sbjct: 753 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
Query: 276 TSVKTLETLQQRVKRQENLLKRCKETIQS----HKEQCTLLTS----EKEALQEQLDERL 327
+ +T + Q + + +RC+ +QS ++++ L EK + + DE
Sbjct: 813 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
Query: 328 QEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE-- 381
QE E +K+ EKT + ++ + L + ++ ++ E ++ + + +++
Sbjct: 873 QECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS 932
Query: 382 --------EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LSTAQKTEEARRK 432
++I +L+S K+ + EE+ Q SE+ A + LE+ + Q+ +E K
Sbjct: 933 ETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSK 992
Query: 433 LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS-------------EEQI- 478
L A M+ K +T++ ER + E+SR++ ++ ++ + +S EE++
Sbjct: 993 LLA-MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
Query: 479 ----AKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
L + E+ L L + E+ +E +K+A E S+ + E S
Sbjct: 1052 GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
Query: 535 LALEELELQKKAILTESENKL----RDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
L+E + E R Q E T R + +LE + L S
Sbjct: 1112 SCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSS--- 1168
Query: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
++ + E + + +ELE+ + + W K Q+ Q Q ++ L C+
Sbjct: 1169 -----VQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI--SQLQEQLMMLCADCD 1221
Query: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKL------------------DVKQTELESLSSE 692
+ E K ++++F + + K LE++ D Q EL + +
Sbjct: 1222 RASE---KKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETR 1278
Query: 693 LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS-------------I 739
E L+ +L E+ L+D+ KM++ E + +K++ + ++++ I
Sbjct: 1279 YDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKI 1338
Query: 740 IKEHEVSIQRTEKALKD------------QINQLELLLKERDKHLKEHQAHVENLEADIK 787
K E +QR + L + I QL L+E ++ +E + + +
Sbjct: 1339 EKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQ 1398
Query: 788 RSEGELQ--------QASAKLDVFQSYQSATHEQTK----------AYEEQLAQLQQKLL 829
EG Q + + Q++Q Q + ++++ Q Q +
Sbjct: 1399 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
Query: 830 DLETERILL------TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
+LE E+ L K+ + ++KDV + + + +++ +M L+ SEM+QKV+
Sbjct: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE-ELKAMMHDLQITCSEMQQKVEL 1517
Query: 884 LTQVYES-KLEDGNKEQEQTKQILVEKE---NMILQMREGQKKEI----EILTQKLSAKE 935
L YES KL+ N L E++ N+ L G ++E+ E + Q+ +A +
Sbjct: 1518 LR--YESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1575
Query: 936 DSIHILNEEY-ETKFKNQEKKME--KVKQKAKEMQETLK---KKLLDQEAKLKKELENTA 989
+ L ++ E K KNQ+ +E ++ QK + QE L+ ++L + + +KE N+A
Sbjct: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA 1635
Query: 990 LELSQKEKQFNAK-MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
LE ++EK FN K LE + S S VS LE E ++ T + ++E
Sbjct: 1636 LEEREQEK-FNLKEELERCKVQS---STLVSSLEAELSE-VKIQTHIVQQE--------N 1682
Query: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
L + E+++++H ++++ +QKI E++ KE L EE L
Sbjct: 1683 HLLKDELEKMKQLHRC------PDLSDFQQKISSVLSYNEKLLKEKEALSEE-------L 1729
Query: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
N ++L + S + +A + + K+ E L L + QE++ L+ +
Sbjct: 1730 NSCVDKLAKSSLLEHRIATMKQEQKS-WEHQSASLKSQLVAS---QEKVQNLEDTVQNVN 1785
Query: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
++S + S L+ T +E ++LK +K L++ K + E+A + + L
Sbjct: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAG--GKSWAPEIATHPSGLHNQQKRLS 1843
Query: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
K + L+N + + Q K L V +LE+ L L + Q L
Sbjct: 1844 WDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL--LPKHQKHL 1898
Query: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
N S T E+E SL E + QKE Q A+ K S + L++EL
Sbjct: 1899 NPS---GTMNPTEQEKL---------SLKRECDQFQKE----QSPANRKVSQMNSLEQEL 1942
Query: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
+ L E LK+K+V+ L +QL ++ L+++ + S A Q ++ C
Sbjct: 1943 ----ETIHLENEGLKKKQVK---LDEQLMEMQ-HLRSTATPSPSPHAWDLQLLQ--QQAC 1992
Query: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
++ + Q L + L E+I+ Q ++ N+ SE Q Q ++E I++E
Sbjct: 1993 PMVPREQFLQLQRQLLQAERINQHLQ-EELENRTSE-TNTPQGNQEQLVTVMEERMIEVE 2050
Query: 1469 LKSKEAYE-KDEQINLLKEEL 1488
K K E++N LKE++
Sbjct: 2051 QKLKLVKRLLQEKVNQLKEQV 2071
Score = 152 bits (383), Expect = 5e-36
Identities = 342/1581 (21%), Positives = 646/1581 (40%), Gaps = 296/1581 (18%)
Query: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
E I EE E + E L L+ + L+E+ A LE EL V K+ + Q
Sbjct: 314 ERILDTWQEEGIENSQEILKALDFSLDG-NINLTELTLA---LENELLVTKNS---IHQA 366
Query: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
A + H ++VD +++E E L+ +++ E L + +H A +E
Sbjct: 367 ALASFKAEIRHLLERVDQVVREKE--------KLRSDLDKAEKLKSLMASEVDDHHAAIE 418
Query: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT- 839
+R+E L+ KLD + Y+E++A L+ +L E E+IL
Sbjct: 419 ------RRNEYNLR----KLD-------------EEYKERIAALKNELRK-EREQILQQA 454
Query: 840 -KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898
KQ E+E + + TE + ++D + K+NS +E ++ LE+ K
Sbjct: 455 GKQRLELEQEIEKAKTEEN----YIRDRLALSLKENSRLENEL----------LENAEK- 499
Query: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI--HILNEEYETKFKNQEKKM 956
L E EN+ ++ Q+ +L +K + S L EE T+ +N+ ++
Sbjct: 500 -------LAEYENLTNKL---QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQ 549
Query: 957 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI-- 1014
+V Q DQ +L+ ELE + E +ANS GI
Sbjct: 550 CRVLQ--------------DQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP 595
Query: 1015 -----SDAVSRLETNQKEQ--IESLTEVHRR-------ELNDVISIWEKKLNQQAEELQE 1060
S+ + L + + + IE + E H R EL D + +EK+L++ ++
Sbjct: 596 EHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKK 655
Query: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120
E Q E E L+++I E E+ + LKE + E ++QL+ K
Sbjct: 656 AQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
Query: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180
+ Q++ +L+ E++L L + E+ E + + KV LT
Sbjct: 716 EEKTHLQEKLRLQH-----EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLT----- 765
Query: 1181 TDEEFQSLKSSHEKSNKSLEDK-SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Q L+ H++ SL +K +LE ++L +EL +K + L+ ++
Sbjct: 766 -----QELEQFHQEQLTSLVEKHTLEKEELRKELL-------EKHQRELQEGREKMETEC 813
Query: 1240 SSKTNAILSRI-SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
+ +T+ I ++ S CQ T + + AL LE + RQ E L ++ Q
Sbjct: 814 NRRTSQIEAQFQSDCQKVTERCESAL-------QSLEGRYRQ---ELKDLQEQQREEKSQ 863
Query: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
E +++++ A+ + L+ KE L++E E+E L+K E++N++ +
Sbjct: 864 WEFEKDELTQECAEAQELL--KETLKREKTTSLVLTQERE----MLEKTYKEHLNSMVVE 917
Query: 1359 KEELKEKKVEISSLSKQ----LTDLNVQLQNSIS--LSEKEAAI--SSLRKQYDEEKCEL 1410
+++L + ++ ++S+ L+D ++L++S L E+E + + +Q ++ E
Sbjct: 918 RQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER 977
Query: 1411 LD-----QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL-- 1463
L+ + Q++ K+ + + E D + S + QS+ + Q L
Sbjct: 978 LEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSM 1037
Query: 1464 -QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Q ++ +E E D ++LL++ + D L ++ + K+ + TE+
Sbjct: 1038 LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS-LQRAHEQAVKENVKMATEISR 1096
Query: 1523 QTARIMELEDHITQKTIEIESLNEVLKN----------YNQQKDIE---HKELVQKLQ-- 1567
R+ +LE + + E E N N+ K +E + ++ L+
Sbjct: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
Query: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
++LG + V+ E KI E V +ELE ++ +++ ELK
Sbjct: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGF-SELENSEE--------TRTESWELKNQIS 1207
Query: 1628 RLESESAAKLAELKRKAEQK------IAAIKKQL--LSQMEEKEEQYKKGTESHLSELNT 1679
+L+ + A+ R +E+K ++ +KK+L L ++ E +YK
Sbjct: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYK-----------L 1256
Query: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
++ RE L+E+L+ +E+ E L +N
Sbjct: 1257 LYEDVSRENDCLQEELRMMETRYDEAL------EN------------------------- 1285
Query: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
+ LT + LQ ++ EE + + Y E I+ E Q I LQE
Sbjct: 1286 --NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQE 1343
Query: 1800 ELEEKNK----KYSLIVAQHVEKEGGKNNIQAKQNLE----------NVFDDVQKTLQEK 1845
+ ++ + SL +++E E N +Q Q LE +V ++ ++ Q
Sbjct: 1344 SVVQRCDCCLWEASL---ENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYL 1400
Query: 1846 ELTCQILEQ----KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
E Q+LE+ +I L + +E RV+ + + + L Q +++ T +
Sbjct: 1401 EGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQAT--IA 1458
Query: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
E EK+K + KL + + G + E E+ + DL++ E Q
Sbjct: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEE------ELKAMMHDLQITCSEMQ 1512
Query: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Q++E+L+ E EK++QE NS L+ + N +E + T+N
Sbjct: 1513 QKVELLRYE-----SEKLQQE--------NSILRNEITTLN-----EEDSISNLKLGTLN 1554
Query: 2022 KAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL 2081
+QE + E+ ++E N ++K+ E K + LD E++ K Q +L
Sbjct: 1555 GSQEEMWQKTETVKQE-NAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKL 1613
Query: 2082 EELQKKYQQKL-EQEENPGNDNVTIM---------ELQTQLAQKTTLI-------SDSKL 2124
+EL ++ + L ++E+ PGN + EL+ Q +TL+ S+ K+
Sbjct: 1614 QELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI 1673
Query: 2125 KEQEFREQIHNLEDRLKKYEK 2145
+ +++ H L+D L+K ++
Sbjct: 1674 QTHIVQQENHLLKDELEKMKQ 1694
Score = 122 bits (306), Expect = 4e-27
Identities = 274/1377 (19%), Positives = 551/1377 (40%), Gaps = 214/1377 (15%)
Query: 890 SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF 949
S L+DG + + +E I +E K L ++ E ++ + NE TK
Sbjct: 302 SCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKN 361
Query: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA 1009
+ + K + + + E + + + ++E KL+ +L+ S + + + +
Sbjct: 362 SIHQAALASFKAEIRHLLERVDQVVREKE-KLRSDLDKAEKLKSLMASEVDDHHAAIERR 420
Query: 1010 NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
N + +L+ KE+I +L R+E ++ QQA + + E ++++
Sbjct: 421 NEYNLR----KLDEEYKERIAALKNELRKEREQIL--------QQAGKQRLELEQEIEKA 468
Query: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH-VNSLAQD 1128
+ E ++ ++ L E + E+ E+ + + N+LQ L+ A L
Sbjct: 469 KTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPS 528
Query: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE---- 1184
+ E+L N+ ++ LQ+Q+ EL+ EE + + L LK + E
Sbjct: 529 SAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEA 588
Query: 1185 ----------------------------FQSLKSSHEKS----NKSLEDKSLEFKKLSEE 1212
+ +K H + LEDK ++K +E
Sbjct: 589 NSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDE 648
Query: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
+ CKK + ++ + + + + + + I+ Q + +KEA TC
Sbjct: 649 TVVS----CKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 704
Query: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
E + QL+ EE+ T + H++E K ++ S E+E LQ +++
Sbjct: 705 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA----SFEREREGLQSSAWTEEK 760
Query: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEI-------------SSLSKQLTDL 1379
+ +++L+ + TL KEEL+++ +E + +++ + +
Sbjct: 761 VRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQI 820
Query: 1380 NVQLQNSIS-LSEK-EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Q Q+ ++E+ E+A+ SL +Y +E +L +Q ++ EK + D+
Sbjct: 821 EAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQRE----------EKSQWEFEKDE 870
Query: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
+ + +E ++ + + + T L + E+ K Y+ E +N + E Q
Sbjct: 871 LTQECAEAQELLKETLKREKTTSLVLTQEREMLEK-TYK--EHLNSMVVERQQ------- 920
Query: 1498 LKGEMEDDKSKMEKKESNLET---ELKSQTAR-IMELEDHITQKTIEIESLNEVLKNYNQ 1553
L ++ED ++ E ++S L ELKS R + E E+ + Q + ++ L+
Sbjct: 921 LLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEM 980
Query: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
+ D E +E++ KL + + + + A+ + + ++ + L++K KE++
Sbjct: 981 EHDQERQEMMSKLLAMENIHKAT---CETADRERAEMSTEI----SRLQSKIKEMQQATS 1033
Query: 1614 SVKSKEEELKAL-EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE- 1671
+ + + + E+ +E + A L + + EQ + LLS E+ K+ +
Sbjct: 1034 PLSMLQSGCQVIGEEEVEGDGALSLLQ---QGEQLLEENGDVLLSLQRAHEQAVKENVKM 1090
Query: 1672 -SHLSELNTKLQEREREVHI---LEEKLKSV---ESSQSETLIVPRSAKNVAAYTEQE-- 1722
+ +S L +LQ+ E + + L+E + Q+E + K V T +
Sbjct: 1091 ATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVL 1150
Query: 1723 ---EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMR---CQYQ 1774
E D + T + + + E E ++ + EET + +E++ Q Q
Sbjct: 1151 SDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ 1210
Query: 1775 ERLIKL----EHAEAKQHE---DQSMIGH---LQEELEEKNKKYSLIVAQHVEKEGGKNN 1824
E+L+ L + A K+ + D S++ + E + E + KY L+ + V +E
Sbjct: 1211 EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY-EDVSRENDCLQ 1269
Query: 1825 IQAKQNLENVFDDVQKTLQEKELTCQI--LEQKIKELDSC------LVRQKEVHRVEMEE 1876
+ + +E +D+ + KELT ++ L+ ++K+++ L + + ++E EE
Sbjct: 1270 EELRM-METRYDEALEN--NKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE 1326
Query: 1877 LT-------SKYEKLQ--ALQQMDGRNKPTELLEENTEEKSKSHLVQ-PKLLSNMEAQHN 1926
L K EKLQ +Q+ D L EN E + +++Q + L +
Sbjct: 1327 LNVLVLRLQGKIEKLQESVVQRCDCCLWEASL--ENLEIEPDGNILQLNQTLEECVPRVR 1384
Query: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
+ + ++E Q L + + ++L K E+ L +E Q Q L
Sbjct: 1385 SVHHVIEECKQENQYL-------EGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVIL 1437
Query: 1987 ELKHNSTLKQLM-REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
E N+TL + F Q E ELE T K QE+ +L E + +
Sbjct: 1438 E--ENTTLLGFQDKHFQHQATIAELELEKT------KLQELTRKLKER--------VTIL 1481
Query: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ------QKLEQEENPG 2099
++ D L K EEE+ A + DLQ E+Q+K + +KL+QE +
Sbjct: 1482 VKQKDVLSHGEK---------EEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSIL 1532
Query: 2100 NDNVTIME---------------LQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
+ +T + Q ++ QKT + Q+ E + LK
Sbjct: 1533 RNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELK 1589
Score = 66.6 bits (161), Expect = 3e-10
Identities = 131/621 (21%), Positives = 258/621 (41%), Gaps = 121/621 (19%)
Query: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
+++ +E LKAL+ L+ L EL E ++ K + + +K L
Sbjct: 325 IENSQEILKALDFSLDGN--INLTELTLALENELLVTKNSI---HQAALASFKAEIRHLL 379
Query: 1675 SELNTKLQEREREVHILE--EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
++ ++E+E+ L+ EKLKS+ +S+ + + AA + E + + + +
Sbjct: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD--------HHAAIERRNEYNLRK-LDE 430
Query: 1733 TYEEKISVLQRNLT-EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791
Y+E+I+ L+ L E+E++LQ+ G+++ E + E + + +E I+ A + + +
Sbjct: 431 EYKERIAALKNELRKEREQILQQAGKQRLE-LEQEIE-KAKTEENYIRDRLALSLKENSR 488
Query: 1792 SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
L+ EL E +K + E E N +Q +NLENV + L +
Sbjct: 489 -----LENELLENAEKLA-------EYENLTNKLQ--RNLENVLAEKFGDLDPSSAEFFL 534
Query: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA---LQQMDGRNKPTELLEENTEEKS 1908
E+++ ++ + RQ V + +++EL S+ E+ +A + ++ +N P+E +E N+
Sbjct: 535 QEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANS---- 590
Query: 1909 KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
+E +H LG E + L + EL I
Sbjct: 591 ----------GGIEPEHG---------------LGSE------ECNPLNMSIEAELVI-- 617
Query: 1969 KEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA 2028
E ++ +H+ + L E ++ E++L+ ET+ ++ +
Sbjct: 618 ---------------EQMKEQHHRDICCLRLELEDKVRHYEKQLD----ETVVSCKKAQE 658
Query: 2029 ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE---EMTAKVRDLQTQLEELQ 2085
+ + H+ ET+ L K+I++ +++ + + +A E + + LQ +LEE +
Sbjct: 659 NMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEK 718
Query: 2086 KKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE---FREQIHNLEDRLKK 2142
Q+KL + MEL+ +L Q + Q E++ L L++
Sbjct: 719 THLQEKLRLQHE--------MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ 770
Query: 2143 YEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGR---ETKTMAKVIT 2199
+ + + V HT L E E L K E GR ET+ +
Sbjct: 771 FHQEQLTSLVEK--------HT---LEKEELRKELLEKHQRELQEGREKMETECNRRTSQ 819
Query: 2200 TVLKFPDDQTQKILEREDARL 2220
+F D QK+ ER ++ L
Sbjct: 820 IEAQFQSD-CQKVTERCESAL 839
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.306
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,835,504
Number of Sequences: 37866
Number of extensions: 3565492
Number of successful extensions: 89426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 871
Number of HSP's successfully gapped in prelim test: 1971
Number of HSP's that attempted gapping in prelim test: 17141
Number of HSP's gapped (non-prelim): 25770
length of query: 2230
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2112
effective length of database: 13,779,330
effective search space: 29101944960
effective search space used: 29101944960
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.