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Search of human proteins with 64464726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|64464726 KN motif and ankyrin repeat domains 1 isoform a
[Homo sapiens]
(1352 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom... 2675 0.0
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 2351 0.0
gi|156104862 ankyrin repeat domain 38 [Homo sapiens] 337 5e-92
gi|209969812 ankyrin repeat domain 25 [Homo sapiens] 330 7e-90
gi|31324547 ankyrin repeat domain 25 [Homo sapiens] 330 7e-90
gi|157504499 ankyrin repeat domain 47 [Homo sapiens] 292 1e-78
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 87 8e-17
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 87 8e-17
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 87 8e-17
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 87 8e-17
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 86 2e-16
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 86 2e-16
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 84 9e-16
gi|55770876 notch4 preproprotein [Homo sapiens] 82 3e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 81 8e-15
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 77 9e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 77 9e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 77 9e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 77 9e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 77 9e-14
gi|18079216 CASK interacting protein 1 [Homo sapiens] 75 6e-13
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 75 6e-13
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 74 1e-12
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 73 2e-12
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 72 3e-12
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 72 4e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 72 4e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 72 4e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 72 4e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 72 4e-12
>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
sapiens]
Length = 1352
Score = 2675 bits (6933), Expect = 0.0
Identities = 1352/1352 (100%), Positives = 1352/1352 (100%)
Query: 1 MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKR 60
MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKR
Sbjct: 1 MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKR 60
Query: 61 LNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISK 120
LNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISK
Sbjct: 61 LNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISK 120
Query: 121 PPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFR 180
PPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFR
Sbjct: 121 PPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFR 180
Query: 181 RPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIR 240
RPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIR
Sbjct: 181 RPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIR 240
Query: 241 HSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQ 300
HSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQ
Sbjct: 241 HSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQ 300
Query: 301 LVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQS 360
LVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQS
Sbjct: 301 LVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQS 360
Query: 361 TQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSR 420
TQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSR
Sbjct: 361 TQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSR 420
Query: 421 SCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETT 480
SCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETT
Sbjct: 421 SCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETT 480
Query: 481 HDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGT 540
HDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGT
Sbjct: 481 HDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGT 540
Query: 541 SVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVC 600
SVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVC
Sbjct: 541 SVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVC 600
Query: 601 ETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEA 660
ETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEA
Sbjct: 601 ETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEA 660
Query: 661 AVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVG 720
AVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVG
Sbjct: 661 AVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVG 720
Query: 721 EGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIA 780
EGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIA
Sbjct: 721 EGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIA 780
Query: 781 CGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTL 840
CGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTL
Sbjct: 781 CGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTL 840
Query: 841 LAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITG 900
LAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITG
Sbjct: 841 LAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITG 900
Query: 901 NYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQI 960
NYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQI
Sbjct: 901 NYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQI 960
Query: 961 AAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSE 1020
AAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSE
Sbjct: 961 AAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSE 1020
Query: 1021 SDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIR 1080
SDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIR
Sbjct: 1021 SDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIR 1080
Query: 1081 ERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYI 1140
ERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYI
Sbjct: 1081 ERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYI 1140
Query: 1141 AAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPI 1200
AAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPI
Sbjct: 1141 AAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPI 1200
Query: 1201 MLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADV 1260
MLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADV
Sbjct: 1201 MLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADV 1260
Query: 1261 NIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
NIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL
Sbjct: 1261 NIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
Query: 1321 YAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD 1352
YAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
Sbjct: 1321 YAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD 1352
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 2351 bits (6092), Expect = 0.0
Identities = 1194/1194 (100%), Positives = 1194/1194 (100%)
Query: 159 METRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQG 218
METRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQG
Sbjct: 1 METRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQG 60
Query: 219 NGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELE 278
NGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELE
Sbjct: 61 NGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELE 120
Query: 279 EQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRA 338
EQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRA
Sbjct: 121 EQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRA 180
Query: 339 RRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGEC 398
RRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGEC
Sbjct: 181 RRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGEC 240
Query: 399 RSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQ 458
RSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQ
Sbjct: 241 RSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQ 300
Query: 459 QQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEA 518
QQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEA
Sbjct: 301 QQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEA 360
Query: 519 VVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMH 578
VVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMH
Sbjct: 361 VVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMH 420
Query: 579 DRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVT 638
DRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVT
Sbjct: 421 DRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVT 480
Query: 639 VCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNT 698
VCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNT
Sbjct: 481 VCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNT 540
Query: 699 CLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKE 758
CLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKE
Sbjct: 541 CLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKE 600
Query: 759 SGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLG 818
SGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLG
Sbjct: 601 SGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLG 660
Query: 819 MMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMK 878
MMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMK
Sbjct: 661 MMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMK 720
Query: 879 SASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPIS 938
SASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPIS
Sbjct: 721 SASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPIS 780
Query: 939 SLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVG 998
SLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVG
Sbjct: 781 SLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVG 840
Query: 999 INGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL 1058
INGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL
Sbjct: 841 INGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGL 900
Query: 1059 KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTL 1118
KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTL
Sbjct: 901 KSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTL 960
Query: 1119 QHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIV 1178
QHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIV
Sbjct: 961 QHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIV 1020
Query: 1179 KLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL 1238
KLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL
Sbjct: 1021 KLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTAL 1080
Query: 1239 MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED 1298
MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED
Sbjct: 1081 MLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED 1140
Query: 1299 NDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD 1352
NDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
Sbjct: 1141 NDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD 1194
>gi|156104862 ankyrin repeat domain 38 [Homo sapiens]
Length = 995
Score = 337 bits (864), Expect = 5e-92
Identities = 215/520 (41%), Positives = 290/520 (55%), Gaps = 94/520 (18%)
Query: 813 PQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSS 872
P +P G Y+++IQ+LL EQ L Y ELA A +P S++ S+ SQL LSS
Sbjct: 552 PSSPTDATIG--QYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQL---LSS 606
Query: 873 INSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTS 932
+N ++ S S+Q P++ +S
Sbjct: 607 LNLLL--------------------------------------SAYSAQAHPPKEPPASS 628
Query: 933 EGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGN--KDSNGA 990
P+ +SP ++LKSIMKKKD NG
Sbjct: 629 SSPPVE-----------ISP------------------STSLKSIMKKKDYGFRAGGNGT 659
Query: 991 KKNLQFVGINGGYETTSSDDSSSDES-----SSSESDDECDVIEYPLEEEEEEEDEDTRG 1045
KKNLQFVG+NGGYETTSS+++S ++S S SE++ +CD ++ ++ E +G
Sbjct: 660 KKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQG 719
Query: 1046 MAEGH-HAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPK 1104
+ EG HA G +E K E RY+ SE+ L+AC L + +
Sbjct: 720 IPEGTCHAAQESG----------PGEEVPHSKAE---RYKPSEEFLNACRALSQHLPETG 766
Query: 1105 ALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNT 1164
T + +R LNT+ EWFRVSS+KS+ PA+V Y+ + SP L+ ++NLAD NGNT
Sbjct: 767 TTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNT 826
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALHYSVSHSNF IVKLLL+ VCNVDHQNKAGYT +M+ LA+ E +DM +V +L G
Sbjct: 827 ALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG 886
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
+VN +A+Q GQTALML VSH R DMV+ LL+C ADVN+QD +GS+ALM A HG+V++V+
Sbjct: 887 NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVR 946
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEA-GHKDIAVLLYAH 1323
LLLA P C+ L D G TALSIAL++ H +IA LL AH
Sbjct: 947 LLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
Score = 72.8 bits (177), Expect = 2e-12
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 21 GDQDKE--QKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRT 78
GD++K+ + PY VETPYG+ LDLDFLKYVDDI+KGNTIKR+ I +R K + PR
Sbjct: 13 GDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRN 72
Query: 79 TS 80
S
Sbjct: 73 FS 74
Score = 30.8 bits (68), Expect = 9.2
Identities = 23/83 (27%), Positives = 43/83 (51%), Gaps = 12/83 (14%)
Query: 431 VEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHD-----REM 485
V+MR+ G+ VTE LG+ + +I SLK+++ LE +L T + +
Sbjct: 318 VDMRSIGIRVTEESLGL-------ARVDPGSISSLKQQVSALEGELSGRTEELAQVRTAL 370
Query: 486 TKLKQELQAAGSRKKVDKATMAQ 508
+ ++E++A R + + T+AQ
Sbjct: 371 QQQEEEIKAREQRIRELEFTVAQ 393
>gi|209969812 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 330 bits (845), Expect = 7e-90
Identities = 186/427 (43%), Positives = 258/427 (60%), Gaps = 22/427 (5%)
Query: 917 PLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGT-LSPVNLTDDQIAAGLYACTNNESTLK 975
P S +S P EV S +P S PTQE T P Q + + ++
Sbjct: 422 PAESSSSPPGSEVA-SLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
Query: 976 SIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEE 1035
SIMK+K+ D +++LQFVG+NGGYE++S D S+++ S ++S E E
Sbjct: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDST----------ENE 530
Query: 1036 EEEEDEDTRGMAEGHHA--VNIEGLKSARVEDEMQ--------VQECEPEKVEIRERYEL 1085
E E +AE K++R E ++ + E R EL
Sbjct: 531 APEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMEL 590
Query: 1086 SEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEA 1145
S ++SAC L+ +++P ALT ++++ T+ EW R++ + A P +V ++ F A
Sbjct: 591 SPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRA 650
Query: 1146 ISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAAL 1205
+S +L YV+N+AD NGNTALHYSVSH+NF +V+ LLD+ VC VD QN+AGY+PIML AL
Sbjct: 651 MSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTAL 710
Query: 1206 AAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDD 1265
A ++ + D+ V +LF G++NAKASQAGQTALMLAVSHGR+D+VK LLAC ADVN+QDD
Sbjct: 711 ATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDD 770
Query: 1266 EGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+GSTALMCA EHGH EI LLLA P C+ L D DGSTAL +AL+AG +IA +LY+ +N
Sbjct: 771 DGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
Query: 1326 FAKAQSP 1332
+ +P
Sbjct: 831 IKCSFAP 837
Score = 147 bits (370), Expect = 9e-35
Identities = 113/287 (39%), Positives = 143/287 (49%), Gaps = 80/287 (27%)
Query: 25 KEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKR-RKPSVPCPEPRTTSGQQ 83
K+ PY VETPYGY+LDLDFLKYVDDI+KG+T++R+ +Q+R R S+P G
Sbjct: 26 KDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLP-------RGPG 78
Query: 84 GIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPP 143
WTSTESL S+ S D++ R LET F
Sbjct: 79 SWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGA------LETRGGF------------ 120
Query: 144 SPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSG 203
N V +TL++ RRRLE + AT G S PS GS
Sbjct: 121 -------NPRVERTLLDARRRLEDQAATPT-----------------GLGSLTPSAAGS- 155
Query: 204 NHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRH-SPLSSGISTPVTNVSPMHLQH 262
T S +G + +P SSG+STPV S HL H
Sbjct: 156 ---------------------------TASLVGVGLPPPTPRSSGLSTPVPP-SAGHLAH 187
Query: 263 IREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQR 309
+REQMA AL++L++LEEQV+ IPVLQVK+SVLQEEKRQL QLK+Q+
Sbjct: 188 VREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQK 234
>gi|31324547 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 330 bits (845), Expect = 7e-90
Identities = 186/427 (43%), Positives = 258/427 (60%), Gaps = 22/427 (5%)
Query: 917 PLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGT-LSPVNLTDDQIAAGLYACTNNESTLK 975
P S +S P EV S +P S PTQE T P Q + + ++
Sbjct: 422 PAESSSSPPGSEVA-SLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR 480
Query: 976 SIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEE 1035
SIMK+K+ D +++LQFVG+NGGYE++S D S+++ S ++S E E
Sbjct: 481 SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDST----------ENE 530
Query: 1036 EEEEDEDTRGMAEGHHA--VNIEGLKSARVEDEMQ--------VQECEPEKVEIRERYEL 1085
E E +AE K++R E ++ + E R EL
Sbjct: 531 APEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMEL 590
Query: 1086 SEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEA 1145
S ++SAC L+ +++P ALT ++++ T+ EW R++ + A P +V ++ F A
Sbjct: 591 SPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRA 650
Query: 1146 ISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAAL 1205
+S +L YV+N+AD NGNTALHYSVSH+NF +V+ LLD+ VC VD QN+AGY+PIML AL
Sbjct: 651 MSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTAL 710
Query: 1206 AAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDD 1265
A ++ + D+ V +LF G++NAKASQAGQTALMLAVSHGR+D+VK LLAC ADVN+QDD
Sbjct: 711 ATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDD 770
Query: 1266 EGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+GSTALMCA EHGH EI LLLA P C+ L D DGSTAL +AL+AG +IA +LY+ +N
Sbjct: 771 DGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMN 830
Query: 1326 FAKAQSP 1332
+ +P
Sbjct: 831 IKCSFAP 837
Score = 147 bits (370), Expect = 9e-35
Identities = 113/287 (39%), Positives = 143/287 (49%), Gaps = 80/287 (27%)
Query: 25 KEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKR-RKPSVPCPEPRTTSGQQ 83
K+ PY VETPYGY+LDLDFLKYVDDI+KG+T++R+ +Q+R R S+P G
Sbjct: 26 KDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLP-------RGPG 78
Query: 84 GIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPP 143
WTSTESL S+ S D++ R LET F
Sbjct: 79 SWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGA------LETRGGF------------ 120
Query: 144 SPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSG 203
N V +TL++ RRRLE + AT G S PS GS
Sbjct: 121 -------NPRVERTLLDARRRLEDQAATPT-----------------GLGSLTPSAAGS- 155
Query: 204 NHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRH-SPLSSGISTPVTNVSPMHLQH 262
T S +G + +P SSG+STPV S HL H
Sbjct: 156 ---------------------------TASLVGVGLPPPTPRSSGLSTPVPP-SAGHLAH 187
Query: 263 IREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQR 309
+REQMA AL++L++LEEQV+ IPVLQVK+SVLQEEKRQL QLK+Q+
Sbjct: 188 VREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQK 234
>gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
Length = 821
Score = 292 bits (748), Expect = 1e-78
Identities = 171/375 (45%), Positives = 231/375 (61%), Gaps = 23/375 (6%)
Query: 974 LKSIMKKKDGNKDS--NGAKKNLQFVGI-NGGYETTSSDDSSSDESSSSESDDECDVIEY 1030
LKSIMKK+DG + + K+LQFVG+ NG YE++SS+D+S + S E
Sbjct: 445 LKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAE------ 498
Query: 1031 PLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKML 1090
P D+ G G G + D E EP++V + R ELS ++
Sbjct: 499 PPGSSSGSGDDSGGGSDSGTPGPPSGG----DIRDPEPEAEAEPQQVA-QGRCELSPRLR 553
Query: 1091 SACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDV 1150
AC L+ ++ P+ + S + + EWFRVSSQ+ + V + + P++
Sbjct: 554 EACVALQRQLSRPRGVASDGG--AVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPEL 611
Query: 1151 LRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAV-E 1209
L +V+NLADGNGNTALHYSVSH N I LLLD C V+ QN+AGY+ +MLAAL +V +
Sbjct: 612 LAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ 671
Query: 1210 AEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGST 1269
E+DM +V+ LF GDVNAKASQ GQTALMLA+SHGR DMV LLACGADVN QD +G+T
Sbjct: 672 EEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGAT 731
Query: 1270 ALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKA 1329
ALMCASE+G ++ V+LLL QPGC+ + DN+G++AL+IALEA ++A LL+AH+
Sbjct: 732 ALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHL----- 786
Query: 1330 QSPGTPRLGRKTSPG 1344
S G P ++ PG
Sbjct: 787 -SSGQPDTQSESPPG 800
Score = 117 bits (294), Expect = 6e-26
Identities = 132/492 (26%), Positives = 200/492 (40%), Gaps = 121/492 (24%)
Query: 25 KEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRL-NIQKRRKPSVPCPEPRTTSGQQ 83
+ PY VETPYG+ LDLDFLKY++++++G +R R+P P P +
Sbjct: 28 RSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPG-LAGARSP 86
Query: 84 GIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPP 143
G WTS+ESL+S D+ P L + P + P
Sbjct: 87 GAWTSSESLAS----DDGGAPGILSQGA-----------------------PSGLLMQPL 119
Query: 144 SPQLPKHNLHVTKTLMETRRRLEQERATMQMTP----GEFRRPRLASFGGMGTTSSLPSF 199
SP+ P N V TL ET RRLE + T + P G R PR
Sbjct: 120 SPRAPVRNPRVEHTLRETSRRLELAQ-THERAPSPGRGVPRSPR---------------- 162
Query: 200 VGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMH 259
GSG +PA + APA+P P
Sbjct: 163 -GSGRSSPAP--------------NLAPASP-------------------------GPAQ 182
Query: 260 LQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGV 319
LQ +REQMA AL+RL+ELE+Q RT+P LQ ++ L+ EK +L++ RA + +
Sbjct: 183 LQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLA----GRAQPEPDGEAE 238
Query: 320 RKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALE- 378
+ A E+L+ + R GG + + + + L ++ +L+
Sbjct: 239 TRPDKLAQLRRLTERLATSER-GGRARASPRADSPDGLAAGRSE-GALQVLDGEVGSLDG 296
Query: 379 -QKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCG 437
+ ++ + EA E RE G + ++A V E
Sbjct: 297 TPQTREVAAEAVPETREAGA-------------------QAVPETREAGVEAAPETVEAD 337
Query: 438 VSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGS 497
VTEA+LG+ A++E+EL + ++E + L +LRE RE E AAG+
Sbjct: 338 AWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAA----EEAAAGA 393
Query: 498 RKKVDKATMAQP 509
R ++ +AT P
Sbjct: 394 RAQLREATTQTP 405
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 [Homo
sapiens]
Length = 627
Score = 87.4 bits (215), Expect = 8e-17
Identities = 59/167 (35%), Positives = 92/167 (55%), Gaps = 8/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + +IVK+LL+ + N++ N+ G+TP+M AA A +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAG-----HV 351
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L G +N +++ ++AL LA G +DMV+ LL GAD + DE TALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 412 ACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/181 (33%), Positives = 92/181 (50%), Gaps = 10/181 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ N++ N GYTP+M AA E +
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVAL 489
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+ + ++NA+ + +TAL LA G ++ L+ GAD+ + ST LM A
Sbjct: 490 LLAQG----ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEA 542
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
S+ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A + K +
Sbjct: 543 SQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Query: 1334 T 1334
T
Sbjct: 602 T 602
Score = 67.4 bits (163), Expect = 9e-11
Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 7/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N G + L + S +E+ ++LL D NK TP+M A+ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ + DVN++ S G TAL A + G +D+VK LL GA++ ++ G T LM A
Sbjct: 291 LLLHD----ADVNSQ-SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345
Query: 1275 SEHGHVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GHVE+ ++LL G N H + S AL++A GH D+ L
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKES-ALTLACYKGHLDMVRFL 391
Score = 61.6 bits (148), Expect = 5e-09
Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
+V + ++ T LM A S G +D+VK LL ADVN Q G+TAL A G V+IVK
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+LL + G N + +G T L A AGH ++A +L H
Sbjct: 323 VLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 45.1 bits (105), Expect = 5e-04
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 1230 ASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQ 1289
A Q +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LLA
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 1290 PGCNGHLED--NDGS-TALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
+ ++ED N G T L A G+ DI LL H +QS
Sbjct: 261 ---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQS 302
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 [Homo
sapiens]
Length = 616
Score = 87.4 bits (215), Expect = 8e-17
Identities = 59/167 (35%), Positives = 92/167 (55%), Gaps = 8/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + +IVK+LL+ + N++ N+ G+TP+M AA A +
Sbjct: 287 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAG-----HV 340
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L G +N +++ ++AL LA G +DMV+ LL GAD + DE TALM
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 401 ACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 446
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/181 (33%), Positives = 92/181 (50%), Gaps = 10/181 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ N++ N GYTP+M AA E +
Sbjct: 420 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVAL 478
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+ + ++NA+ + +TAL LA G ++ L+ GAD+ + ST LM A
Sbjct: 479 LLAQG----ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEA 531
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
S+ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A + K +
Sbjct: 532 SQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
Query: 1334 T 1334
T
Sbjct: 591 T 591
Score = 67.4 bits (163), Expect = 9e-11
Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 7/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N G + L + S +E+ ++LL D NK TP+M A+ +
Sbjct: 220 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 279
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ + DVN++ S G TAL A + G +D+VK LL GA++ ++ G T LM A
Sbjct: 280 LLLHD----ADVNSQ-SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334
Query: 1275 SEHGHVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GHVE+ ++LL G N H + S AL++A GH D+ L
Sbjct: 335 ASAGHVEVARVLLDHGAGINTHSNEFKES-ALTLACYKGHLDMVRFL 380
Score = 61.6 bits (148), Expect = 5e-09
Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
+V + ++ T LM A S G +D+VK LL ADVN Q G+TAL A G V+IVK
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+LL + G N + +G T L A AGH ++A +L H
Sbjct: 312 VLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
Score = 45.1 bits (105), Expect = 5e-04
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 1230 ASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQ 1289
A Q +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LLA
Sbjct: 190 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 249
Query: 1290 PGCNGHLED--NDGS-TALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
+ ++ED N G T L A G+ DI LL H +QS
Sbjct: 250 ---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQS 291
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 87.4 bits (215), Expect = 8e-17
Identities = 59/167 (35%), Positives = 92/167 (55%), Gaps = 8/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + +IVK+LL+ + N++ N+ G+TP+M AA A +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAG-----HV 351
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L G +N +++ ++AL LA G +DMV+ LL GAD + DE TALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 412 ACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 79.7 bits (195), Expect = 2e-14
Identities = 61/191 (31%), Positives = 93/191 (48%), Gaps = 10/191 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ N++ N GYTP+M AA E +
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVAL 489
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+ + ++NA+ + +TAL LA G ++ L+ GAD+ + ST LM A
Sbjct: 490 LLAQG----ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEA 542
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
S+ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A + G
Sbjct: 543 SQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
Query: 1334 TPRLGRKTSPG 1344
L + G
Sbjct: 602 RTPLMKAARAG 612
Score = 75.1 bits (183), Expect = 4e-13
Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 7/166 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
N NTAL + E+V LLLD NV+H+ K G TP+M AA AE ++++
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGY-AEVGRVLLDK- 1279
Query: 1221 FGCGDVNAKASQAGQ-TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGH 1279
DVNA + + TAL +A G + L+ GA +++++ +G+T L AS GH
Sbjct: 1280 --GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
++V+LL+ Q G + DN T L A GH + L VN
Sbjct: 1338 FDVVQLLV-QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 69.7 bits (169), Expect = 2e-11
Identities = 54/164 (32%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 1159 DGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVE 1218
+ N +TAL + + + E+V +L+ D ++H++K G+TP++LAA A + +VE
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAATAG-----HVGVVE 1105
Query: 1219 ELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEH 1277
L G D+ A++ + T L LA S GR ++V LLA GA+ ++ T L A+
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 1278 GHVEIVKLLL-AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
G+V I+K+LL A N G + L +A GH LL
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Score = 67.4 bits (163), Expect = 9e-11
Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 7/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N G + L + S +E+ ++LL D NK TP+M A+ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ + DVN++ S G TAL A + G +D+VK LL GA++ ++ G T LM A
Sbjct: 291 LLLHD----ADVNSQ-SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345
Query: 1275 SEHGHVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GHVE+ ++LL G N H + S AL++A GH D+ L
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKES-ALTLACYKGHLDMVRFL 391
Score = 63.2 bits (152), Expect = 2e-09
Identities = 43/137 (31%), Positives = 74/137 (54%), Gaps = 7/137 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ G+TAL Y+ + + ++ +LL A +++H+++ G TP+M AA A +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARAG-----HL 614
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
V+ L G +VN + T + LA + G + +V+ LLA GAD + +GST L+
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 1274 ASEHGHVEIVKLLLAQP 1290
A++ GH +V LL P
Sbjct: 675 AAKGGHTNVVSYLLDYP 691
Score = 61.6 bits (148), Expect = 5e-09
Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
+V + ++ T LM A S G +D+VK LL ADVN Q G+TAL A G V+IVK
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+LL + G N + +G T L A AGH ++A +L H
Sbjct: 323 VLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/168 (32%), Positives = 82/168 (48%), Gaps = 11/168 (6%)
Query: 1164 TALHYSVSHSNFEIVKLLLDADV-CNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
T L + S I+K+LL+A N +K G +P+MLAA+ + V+ L
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG-----HVPAVKLLLD 1211
Query: 1223 CG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G D+NA+ TAL LA GR ++V LL A+V + G T LM A+ G+ E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 1282 IVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVN 1325
+ ++LL + N + TAL+IA + GH LL AH++
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
Score = 58.9 bits (141), Expect = 3e-08
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 1198 TPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACG 1257
TP+M A+ E + +V+ L G + G TAL A +G D+ LL G
Sbjct: 537 TPLMEAS-----QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 1258 ADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
AD+ + + G T LM A+ GH+ V+ L+++ N+ T +S+A GH +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 1318 VLLYAH 1323
LL AH
Sbjct: 652 ELLLAH 657
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 12/166 (7%)
Query: 1163 NTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
+T L + + E+VK LL A NV G T + A + + L
Sbjct: 536 STPLMEASQEGHLELVKYLL-ASGANVHATTATGDTALTYAC-----ENGHTDVADVLLQ 589
Query: 1223 CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN---IQDDEGSTALMCASEHGH 1279
G S+ G+T LM A G + V+ L++ GA+VN +D +L CA GH
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG--GH 647
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+ +V+LLLA G + DGST L A + GH ++ L + N
Sbjct: 648 LAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
Score = 45.1 bits (105), Expect = 5e-04
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 1230 ASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQ 1289
A Q +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LLA
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 1290 PGCNGHLED--NDGS-TALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
+ ++ED N G T L A G+ DI LL H +QS
Sbjct: 261 ---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQS 302
Score = 35.0 bits (79), Expect = 0.49
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 1269 TALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK 1328
TAL A GH E+V +L+A+ H D G T L +A AGH + +L +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 1329 AQSPGT 1334
AQS T
Sbjct: 1116 AQSERT 1121
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 87.4 bits (215), Expect = 8e-17
Identities = 59/167 (35%), Positives = 92/167 (55%), Gaps = 8/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + +IVK+LL+ + N++ N+ G+TP+M AA A +
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAG-----HV 351
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L G +N +++ ++AL LA G +DMV+ LL GAD + DE TALM
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 412 ACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 79.7 bits (195), Expect = 2e-14
Identities = 61/191 (31%), Positives = 93/191 (48%), Gaps = 10/191 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ N++ N GYTP+M AA E +
Sbjct: 431 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVAL 489
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+ + ++NA+ + +TAL LA G ++ L+ GAD+ + ST LM A
Sbjct: 490 LLAQG----ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEA 542
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
S+ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A + G
Sbjct: 543 SQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
Query: 1334 TPRLGRKTSPG 1344
L + G
Sbjct: 602 RTPLMKAARAG 612
Score = 75.1 bits (183), Expect = 4e-13
Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 7/166 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
N NTAL + E+V LLLD NV+H+ K G TP+M AA AE ++++
Sbjct: 1223 NRNTALTLACFQGRAEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGY-AEVGRVLLDK- 1279
Query: 1221 FGCGDVNAKASQAGQ-TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGH 1279
DVNA + + TAL +A G + L+ GA +++++ +G+T L AS GH
Sbjct: 1280 --GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
++V+LL+ Q G + DN T L A GH + L VN
Sbjct: 1338 FDVVQLLV-QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 69.7 bits (169), Expect = 2e-11
Identities = 54/164 (32%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 1159 DGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVE 1218
+ N +TAL + + + E+V +L+ D ++H++K G+TP++LAA A + +VE
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDA-KIEHRDKKGFTPLILAATAG-----HVGVVE 1105
Query: 1219 ELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEH 1277
L G D+ A++ + T L LA S GR ++V LLA GA+ ++ T L A+
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 1278 GHVEIVKLLL-AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
G+V I+K+LL A N G + L +A GH LL
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Score = 67.4 bits (163), Expect = 9e-11
Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 7/167 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N G + L + S +E+ ++LL D NK TP+M A+ +
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ + DVN++ S G TAL A + G +D+VK LL GA++ ++ G T LM A
Sbjct: 291 LLLHD----ADVNSQ-SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345
Query: 1275 SEHGHVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GHVE+ ++LL G N H + S AL++A GH D+ L
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKES-ALTLACYKGHLDMVRFL 391
Score = 63.2 bits (152), Expect = 2e-09
Identities = 43/137 (31%), Positives = 74/137 (54%), Gaps = 7/137 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ G+TAL Y+ + + ++ +LL A +++H+++ G TP+M AA A +
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARAG-----HL 614
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
V+ L G +VN + T + LA + G + +V+ LLA GAD + +GST L+
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 1274 ASEHGHVEIVKLLLAQP 1290
A++ GH +V LL P
Sbjct: 675 AAKGGHTNVVSYLLDYP 691
Score = 61.6 bits (148), Expect = 5e-09
Identities = 41/99 (41%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
+V + ++ T LM A S G +D+VK LL ADVN Q G+TAL A G V+IVK
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+LL + G N + +G T L A AGH ++A +L H
Sbjct: 323 VLLNE-GANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/168 (32%), Positives = 82/168 (48%), Gaps = 11/168 (6%)
Query: 1164 TALHYSVSHSNFEIVKLLLDADV-CNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
T L + S I+K+LL+A N +K G +P+MLAA+ + V+ L
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG-----HVPAVKLLLD 1211
Query: 1223 CG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G D+NA+ TAL LA GR ++V LL A+V + G T LM A+ G+ E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 1282 IVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVN 1325
+ ++LL + N + TAL+IA + GH LL AH++
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
Score = 58.9 bits (141), Expect = 3e-08
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 1198 TPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACG 1257
TP+M A+ E + +V+ L G + G TAL A +G D+ LL G
Sbjct: 537 TPLMEAS-----QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 1258 ADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
AD+ + + G T LM A+ GH+ V+ L+++ N+ T +S+A GH +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 1318 VLLYAH 1323
LL AH
Sbjct: 652 ELLLAH 657
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 12/166 (7%)
Query: 1163 NTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
+T L + + E+VK LL A NV G T + A + + L
Sbjct: 536 STPLMEASQEGHLELVKYLL-ASGANVHATTATGDTALTYAC-----ENGHTDVADVLLQ 589
Query: 1223 CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN---IQDDEGSTALMCASEHGH 1279
G S+ G+T LM A G + V+ L++ GA+VN +D +L CA GH
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG--GH 647
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+ +V+LLLA G + DGST L A + GH ++ L + N
Sbjct: 648 LAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
Score = 45.1 bits (105), Expect = 5e-04
Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 1230 ASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQ 1289
A Q +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LLA
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 260
Query: 1290 PGCNGHLED--NDGS-TALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
+ ++ED N G T L A G+ DI LL H +QS
Sbjct: 261 ---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQS 302
Score = 35.0 bits (79), Expect = 0.49
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 1269 TALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAK 1328
TAL A GH E+V +L+A+ H D G T L +A AGH + +L +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 1329 AQSPGT 1334
AQS T
Sbjct: 1116 AQSERT 1121
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 85.9 bits (211), Expect = 2e-16
Identities = 59/166 (35%), Positives = 92/166 (55%), Gaps = 6/166 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + ++VK+LL++ DH N+ G+TP+M A A E
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH-NENGHTPLMEAGSAG-HVEVAR 384
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++E G G +N +++ ++AL LA G ++MV+ LL GAD + DE TALM A
Sbjct: 385 LLLEN--GAG-INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 442 CMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 486
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/192 (32%), Positives = 96/192 (50%), Gaps = 12/192 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ +++ N GYTP+M AA E
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGA-SLEEVNDEGYTPLMEAAREGHE----- 513
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+V L G G ++NA+ + +TAL LA G +++ L+ GAD+ + ST LM
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLME 570
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSP 1332
A++ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A +
Sbjct: 571 AAQEGHLELVKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 629
Query: 1333 GTPRLGRKTSPG 1344
G L + G
Sbjct: 630 GRTPLMKAARAG 641
Score = 75.5 bits (184), Expect = 3e-13
Identities = 56/166 (33%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
N NTAL + E+V LLLD NV+H+ K G TP+M AA AE ++++
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGY-AEVGRVLLDK- 1307
Query: 1221 FGCGDVNAKASQAGQ-TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGH 1279
DVNA + + TAL +A G + L+ GA +++++ +G+T L A+ GH
Sbjct: 1308 --GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1365
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+++V+LL+ Q G + DN T L A GH + L VN
Sbjct: 1366 LDVVQLLV-QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410
Score = 70.9 bits (172), Expect = 8e-12
Identities = 69/239 (28%), Positives = 112/239 (46%), Gaps = 24/239 (10%)
Query: 1091 SACNLLKNTINDPKALTSKDMRFCLNTLQHEWFR-VSSQKSAIPAMVGDYIAAFEAISPD 1149
S L +T++D A S NT H +S ++ P+ + ISP
Sbjct: 1014 SPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPI---------ISPS 1064
Query: 1150 VLRYVINLAD------GNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLA 1203
+ + D N +TAL + + + E+V+ LL+ +++H++K G+TP++LA
Sbjct: 1065 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILA 1123
Query: 1204 ALAAVEAEKDMRIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI 1262
A A + +VE L G D+ A++ + T L LA S GR ++V+ LLA GA+
Sbjct: 1124 ATAG-----HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEH 1178
Query: 1263 QDDEGSTALMCASEHGHVEIVKLLL-AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
++ T L A+ G+V I+K+LL A N G + L +A GH LL
Sbjct: 1179 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/323 (24%), Positives = 136/323 (42%), Gaps = 39/323 (12%)
Query: 998 GINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEG 1057
G GG TSS++S +E E ++ +V + L++++ E M E + + G
Sbjct: 103 GGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENP-----MLETASKLLLSG 157
Query: 1058 LKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNT 1117
D ++ +PE E +L A + K + D KA ++ L
Sbjct: 158 -----TADGADLRTVDPET------QARLEALLEAAGIGKLSTADGKAFADPEVLRRLT- 205
Query: 1118 LQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEI 1177
S++ + + AA + + A + N +L + S +
Sbjct: 206 ------------SSVSCALDEAAAALTRMRAESTAN----AGQSDNRSLAEACSEGDVNA 249
Query: 1178 VKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTA 1237
V+ LL + +V+ + G + + LA A + + +V + + T
Sbjct: 250 VRKLL-IEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH----ANVEDRGIKGDITP 304
Query: 1238 LMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLE 1297
LM A + G + +VK LLA ADVN Q G+TAL A G+V++VK+LL + G +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIEDH 363
Query: 1298 DNDGSTALSIALEAGHKDIAVLL 1320
+ +G T L A AGH ++A LL
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLL 386
Score = 62.8 bits (151), Expect = 2e-09
Identities = 42/126 (33%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 1198 TPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACG 1257
TP+M AA E + +V+ L G + G TAL A +G D+ LL G
Sbjct: 566 TPLMEAA-----QEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 1258 ADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
AD+ + + G T LM A+ GHV V+ L+++ N+ T LS+A GH +
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 1318 VLLYAH 1323
LL AH
Sbjct: 681 ELLLAH 686
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/137 (32%), Positives = 74/137 (54%), Gaps = 7/137 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ G+TAL Y+ + + ++ +LL A +++H+++ G TP+M AA A +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARAG-----HV 643
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
V+ L G +VN + T L LA + G + +V+ LLA GAD + +GST L+
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 1274 ASEHGHVEIVKLLLAQP 1290
A++ GH +V LL P
Sbjct: 704 AAKGGHTSVVCYLLDYP 720
Score = 61.2 bits (147), Expect = 6e-09
Identities = 57/171 (33%), Positives = 83/171 (48%), Gaps = 17/171 (9%)
Query: 1164 TALHYSVSHSNFEIVKLLLDADV-CNVDHQNKAGYTPIMLAAL----AAVEAEKDMRIVE 1218
T L + S I+K+LL+A N +K G +P+MLAA+ AAV+ DM
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG--- 1241
Query: 1219 ELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHG 1278
D+NA+ TAL LA GR ++V LL A+V + G T LM A+ G
Sbjct: 1242 -----SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1296
Query: 1279 HVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVN 1325
+ E+ ++LL + N + TAL+IA + GH LL AH++
Sbjct: 1297 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1347
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 14/184 (7%)
Query: 1163 NTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
+T L + + E+VK LL A NV G T + A + + L
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA-NVHATTATGDTALTYAC-----ENGHTDVADVLLQ 618
Query: 1223 CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN---IQDDEGSTALMCASEHGH 1279
G S+ G+T LM A G + V+ L++ GA+VN +D +L CA GH
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG--GH 676
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGR 1339
+ +V+LLLA G + DGST L A + GH + L + N + P P + +
Sbjct: 677 LAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP--PDVTQ 733
Query: 1340 KTSP 1343
T P
Sbjct: 734 LTPP 737
Score = 50.1 bits (118), Expect = 1e-05
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 1228 AKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLL 1287
A A Q+ +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LL
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
Query: 1288 AQPGCNGHLEDND---GSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
A + ++ED T L A GH I LL AH AQS
Sbjct: 288 AM---HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQS 331
Score = 35.0 bits (79), Expect = 0.49
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 1259 DVNIQDDEG-STALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
D++ Q + TAL A GH E+V+ LL + H D G T L +A AGH +
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEH-RDKKGFTPLILAATAGHVGVV 1132
Query: 1318 VLLYAHVNFAKAQSPGT 1334
+L + +AQS T
Sbjct: 1133 EILLDNGADIEAQSERT 1149
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 85.9 bits (211), Expect = 2e-16
Identities = 59/166 (35%), Positives = 92/166 (55%), Gaps = 6/166 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N GNTAL Y+ + ++VK+LL++ DH N+ G+TP+M A A E
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH-NENGHTPLMEAGSAG-HVEVAR 384
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++E G G +N +++ ++AL LA G ++MV+ LL GAD + DE TALM A
Sbjct: 385 LLLEN--GAG-INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
GHVE+ +LLL G ++ + + L++A GH ++A LL
Sbjct: 442 CMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 486
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/192 (32%), Positives = 96/192 (50%), Gaps = 12/192 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ + + L + + E+ LL++ +++ N GYTP+M AA E
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGA-SLEEVNDEGYTPLMEAAREGHE----- 513
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+V L G G ++NA+ + +TAL LA G +++ L+ GAD+ + ST LM
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLME 570
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSP 1332
A++ GH+E+VK LLA G N H G TAL+ A E GH D+A VLL A +
Sbjct: 571 AAQEGHLELVKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 629
Query: 1333 GTPRLGRKTSPG 1344
G L + G
Sbjct: 630 GRTPLMKAARAG 641
Score = 75.5 bits (184), Expect = 3e-13
Identities = 56/166 (33%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
N NTAL + E+V LLLD NV+H+ K G TP+M AA AE ++++
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGY-AEVGRVLLDK- 1056
Query: 1221 FGCGDVNAKASQAGQ-TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGH 1279
DVNA + + TAL +A G + L+ GA +++++ +G+T L A+ GH
Sbjct: 1057 --GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGH 1114
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVN 1325
+++V+LL+ Q G + DN T L A GH + L VN
Sbjct: 1115 LDVVQLLV-QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
Score = 70.1 bits (170), Expect = 1e-11
Identities = 54/164 (32%), Positives = 88/164 (53%), Gaps = 8/164 (4%)
Query: 1159 DGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVE 1218
+ N +TAL + + + E+V+ LL+ +++H++K G+TP++LAA A + +VE
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAG-----HVGVVE 882
Query: 1219 ELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEH 1277
L G D+ A++ + T L LA S GR ++V+ LLA GA+ ++ T L A+
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
Query: 1278 GHVEIVKLLL-AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
G+V I+K+LL A N G + L +A GH LL
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/323 (24%), Positives = 136/323 (42%), Gaps = 39/323 (12%)
Query: 998 GINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEG 1057
G GG TSS++S +E E ++ +V + L++++ E M E + + G
Sbjct: 103 GGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENP-----MLETASKLLLSG 157
Query: 1058 LKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNT 1117
D ++ +PE E +L A + K + D KA ++ L
Sbjct: 158 -----TADGADLRTVDPET------QARLEALLEAAGIGKLSTADGKAFADPEVLRRLT- 205
Query: 1118 LQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEI 1177
S++ + + AA + + A + N +L + S +
Sbjct: 206 ------------SSVSCALDEAAAALTRMRAESTAN----AGQSDNRSLAEACSEGDVNA 249
Query: 1178 VKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTA 1237
V+ LL + +V+ + G + + LA A + + +V + + T
Sbjct: 250 VRKLL-IEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH----ANVEDRGIKGDITP 304
Query: 1238 LMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLE 1297
LM A + G + +VK LLA ADVN Q G+TAL A G+V++VK+LL + G +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIEDH 363
Query: 1298 DNDGSTALSIALEAGHKDIAVLL 1320
+ +G T L A AGH ++A LL
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLL 386
Score = 62.8 bits (151), Expect = 2e-09
Identities = 42/126 (33%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 1198 TPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACG 1257
TP+M AA E + +V+ L G + G TAL A +G D+ LL G
Sbjct: 566 TPLMEAA-----QEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 1258 ADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
AD+ + + G T LM A+ GHV V+ L+++ N+ T LS+A GH +
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 1318 VLLYAH 1323
LL AH
Sbjct: 681 ELLLAH 686
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/137 (32%), Positives = 74/137 (54%), Gaps = 7/137 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ G+TAL Y+ + + ++ +LL A +++H+++ G TP+M AA A +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARAG-----HV 643
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
V+ L G +VN + T L LA + G + +V+ LLA GAD + +GST L+
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 1274 ASEHGHVEIVKLLLAQP 1290
A++ GH +V LL P
Sbjct: 704 AAKGGHTSVVCYLLDYP 720
Score = 61.2 bits (147), Expect = 6e-09
Identities = 57/171 (33%), Positives = 83/171 (48%), Gaps = 17/171 (9%)
Query: 1164 TALHYSVSHSNFEIVKLLLDADV-CNVDHQNKAGYTPIMLAAL----AAVEAEKDMRIVE 1218
T L + S I+K+LL+A N +K G +P+MLAA+ AAV+ DM
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG--- 990
Query: 1219 ELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHG 1278
D+NA+ TAL LA GR ++V LL A+V + G T LM A+ G
Sbjct: 991 -----SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1045
Query: 1279 HVEIVKLLLAQ-PGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVN 1325
+ E+ ++LL + N + TAL+IA + GH LL AH++
Sbjct: 1046 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHID 1096
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 14/184 (7%)
Query: 1163 NTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
+T L + + E+VK LL A NV G T + A + + L
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA-NVHATTATGDTALTYAC-----ENGHTDVADVLLQ 618
Query: 1223 CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN---IQDDEGSTALMCASEHGH 1279
G S+ G+T LM A G + V+ L++ GA+VN +D +L CA GH
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG--GH 676
Query: 1280 VEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGR 1339
+ +V+LLLA G + DGST L A + GH + L + N + P P + +
Sbjct: 677 LAVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPP--PDVTQ 733
Query: 1340 KTSP 1343
T P
Sbjct: 734 LTPP 737
Score = 50.1 bits (118), Expect = 1e-05
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 1228 AKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLL 1287
A A Q+ +L A S G ++ V+ LL G VN +EG + L A G+ E+ ++LL
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 287
Query: 1288 AQPGCNGHLEDND---GSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
A + ++ED T L A GH I LL AH AQS
Sbjct: 288 AM---HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQS 331
Score = 35.0 bits (79), Expect = 0.49
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 1259 DVNIQDDEG-STALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA 1317
D++ Q + TAL A GH E+V+ LL + H D G T L +A AGH +
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEH-RDKKGFTPLILAATAGHVGVV 881
Query: 1318 VLLYAHVNFAKAQSPGT 1334
+L + +AQS T
Sbjct: 882 EILLDNGADIEAQSERT 898
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 84.0 bits (206), Expect = 9e-16
Identities = 59/169 (34%), Positives = 94/169 (55%), Gaps = 10/169 (5%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
A ++ N ++KLLL++ +VD ++ G T +M+AA A + V EL G
Sbjct: 15 AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAG-----HIDCVRELVLQG 69
Query: 1225 -DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIV 1283
D+N + ++G TAL A G D+V+ L GA + +G TAL+ AS++GH+++V
Sbjct: 70 ADINLQ-RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
Query: 1284 KLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSP 1332
+ LL + G N H + DG+TAL +A + G+ D+ LL A + AK P
Sbjct: 129 ETLL-KHGANIHDQLYDGATALFLAAQGGYLDVIRLLLA--SGAKVNQP 174
Score = 72.8 bits (177), Expect = 2e-12
Identities = 55/194 (28%), Positives = 102/194 (52%), Gaps = 8/194 (4%)
Query: 1152 RYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAE 1211
R ++ D +G T L + + + V+ L+ +++ Q ++G T + AA +
Sbjct: 36 RVDVDCRDSHGTTLLMVAAYAGHIDCVRELV-LQGADINLQRESGTTALFFAAQ---QGH 91
Query: 1212 KDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTAL 1271
D +V LFG G ++ G TAL+ A +G + +V+ LL GA+++ Q +G+TAL
Sbjct: 92 ND--VVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATAL 149
Query: 1272 MCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQ 1330
A++ G++++++LLLA G + DG+ L IA + GH ++ V+L + A+
Sbjct: 150 FLAAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAAR 208
Query: 1331 SPGTPRLGRKTSPG 1344
+ GT L + + G
Sbjct: 209 NDGTTALLKAANKG 222
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/181 (27%), Positives = 90/181 (49%), Gaps = 15/181 (8%)
Query: 1149 DVLRYVINLADG------NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIML 1202
DV+R++ +G TAL + + + ++V+ LL N+ Q G T + L
Sbjct: 93 DVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA-NIHDQLYDGATALFL 151
Query: 1203 AALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI 1262
AA + ++ L G + Q G L +A G ++V+ +L GAD +
Sbjct: 152 AAQGGY-----LDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
Query: 1263 QDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGH-KDIAVLLY 1321
++G+TAL+ A+ G+ +++K LL G L+ +G++AL A+ +G+ K +A+LL
Sbjct: 207 ARNDGTTALLKAANKGYNDVIKELLKFSPTLGILK--NGTSALHAAVLSGNIKTVALLLE 264
Query: 1322 A 1322
A
Sbjct: 265 A 265
Score = 31.2 bits (69), Expect = 7.1
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 3/64 (4%)
Query: 1268 STALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA---VLLYAHV 1324
+ A A+ G++ ++KLLL + D+ G+T L +A AGH D VL A +
Sbjct: 13 ANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADI 72
Query: 1325 NFAK 1328
N +
Sbjct: 73 NLQR 76
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 82.0 bits (201), Expect = 3e-15
Identities = 65/190 (34%), Positives = 89/190 (46%), Gaps = 17/190 (8%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N D G T LH +V+ E+ +LLL + VD + + G TP+MLAA AVE
Sbjct: 1661 NQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVED----- 1715
Query: 1216 IVEELFGC-GDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+VEEL DV A+ + G+TAL A + + LL GAD + QD+ T L A
Sbjct: 1716 LVEELIAAQADVGAR-DKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1774
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGT 1334
+ G VE+ +LLL G L D G +A + H D+ LL + G
Sbjct: 1775 AREGAVEVAQLLLGL-GAARELRDQAGLAPADVAHQRNHWDLLTLL---------EGAGP 1824
Query: 1335 PRLGRKTSPG 1344
P K +PG
Sbjct: 1825 PEARHKATPG 1834
Score = 45.8 bits (107), Expect = 3e-04
Identities = 48/169 (28%), Positives = 65/169 (38%), Gaps = 30/169 (17%)
Query: 1181 LLDADVCNVDHQNKAGYTPIMLAA----------------------------LAAVEAEK 1212
LLD C H G TP+ LAA L A A
Sbjct: 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAAD 1678
Query: 1213 DMRIVEELFGCGDVNAKA-SQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTAL 1271
+ + L A ++ G T LMLA D+V+ L+A ADV +D G TAL
Sbjct: 1679 AREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTAL 1738
Query: 1272 MCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A+ + + LL Q G + +DN T L +A G ++A LL
Sbjct: 1739 HWAAAVNNARAARSLL-QAGADKDAQDNREQTPLFLAAREGAVEVAQLL 1786
Score = 36.6 bits (83), Expect = 0.17
Identities = 28/89 (31%), Positives = 37/89 (41%)
Query: 1234 GQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCN 1293
G+T L LA R + LL GA+ N D G T L A E+ +LLL
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTA 1693
Query: 1294 GHLEDNDGSTALSIALEAGHKDIAVLLYA 1322
DG+T L +A +D+ L A
Sbjct: 1694 VDARTEDGTTPLMLAARLAVEDLVEELIA 1722
Score = 34.3 bits (77), Expect = 0.83
Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 6/103 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+ D G TALH++ + +N + LL A + D Q+ TP+ LAA E +
Sbjct: 1727 VGARDKWGKTALHWAAAVNNARAARSLLQAG-ADKDAQDNREQTPLFLAA-----REGAV 1780
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACG 1257
+ + L G G QAG +A D++ L G
Sbjct: 1781 EVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 80.9 bits (198), Expect = 8e-15
Identities = 57/169 (33%), Positives = 83/169 (49%), Gaps = 7/169 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D NG T L + + ++V LL+ +++ ++ G+TP+ LAA +
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA-DLEIEDAHGHTPLTLAA-----RQGHT 591
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++V L GCG Q G TAL A G ++V LL G V+ D + TAL A
Sbjct: 592 KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ GH +IV L L Q G + DN+G TAL A GH++I L H
Sbjct: 652 AWGGHEDIV-LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 78.2 bits (191), Expect = 5e-14
Identities = 55/162 (33%), Positives = 82/162 (50%), Gaps = 2/162 (1%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N AD G TAL + + EIV+ LLD V+H++ G T + +AAL ++
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGA-EVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+V L G + G T L++A G +D+V LL GADV+ D+ G T L+ A
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDI 1316
+ GH +V LL G D++G T LSIA G+ ++
Sbjct: 789 ASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEV 829
Score = 73.6 bits (179), Expect = 1e-12
Identities = 64/201 (31%), Positives = 96/201 (47%), Gaps = 40/201 (19%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N D +G + +++ V++LL+ + N+D + G + +AAL E +D
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALRVAAL---EGHRD-- 927
Query: 1216 IVEELFGCG-DVNAK-------------------------------ASQA-GQTALMLAV 1242
IVE LF G DVN K AS A G+TAL ++
Sbjct: 928 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987
Query: 1243 SHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGS 1302
G ++MV+ L+A ADVN D+E +AL A+ GHV++V+LL+ H N G+
Sbjct: 988 WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH-TCNQGA 1046
Query: 1303 TALSIALEAGHKDIAVLLYAH 1323
TAL IA + GH D+ +L H
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEH 1067
Score = 73.2 bits (178), Expect = 2e-12
Identities = 57/171 (33%), Positives = 83/171 (48%), Gaps = 12/171 (7%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+ + D +G+T L + + ++V L+ N++H ++ G+T + AA
Sbjct: 571 LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA-NINHTDQDGWTALRSAAWGG-----HT 624
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+V L G A +TAL A G D+V LL GA+VN D+EG TAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIA-----LEAGHKDIAVLL 1320
+ GH EIV+ LL G + ED DG TALS+A GH + LL
Sbjct: 685 AYMGHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
Score = 73.2 bits (178), Expect = 2e-12
Identities = 59/171 (34%), Positives = 85/171 (49%), Gaps = 12/171 (7%)
Query: 1155 INLADGNGNTALHYSV-----SHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVE 1209
+N D +G TAL + S + +V LL+D VDH +K G TP+++AA
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA-EVDHCDKDGMTPLLVAAY---- 757
Query: 1210 AEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGST 1269
E + +V+ L G G+T L+ A S G +V LL GA V+ D EG T
Sbjct: 758 -EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
Query: 1270 ALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
L AS G+VE+V+ LL + G + + D+ G T L +A GH+ I L
Sbjct: 817 VLSIASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Score = 71.2 bits (173), Expect = 6e-12
Identities = 46/134 (34%), Positives = 72/134 (53%), Gaps = 10/134 (7%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLL--DADVCNVDHQNKAGYTPIMLAALAAVEAEK 1212
+ +D G TALH S + E+V++L+ ADV D++ ++ AL + +
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS--------ALQSAAWQG 1023
Query: 1213 DMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALM 1272
+++V+ L G V G TAL +A G ID+V+ LL GAD N D G TA+
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083
Query: 1273 CASEHGHVEIVKLL 1286
A+++GH +I+KLL
Sbjct: 1084 VAAKNGHSQIIKLL 1097
Score = 70.9 bits (172), Expect = 8e-12
Identities = 51/166 (30%), Positives = 80/166 (48%), Gaps = 7/166 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ D +G T L + + ++V LLL+ +VDH + G TP++ AA +
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA-DVDHTDNNGRTPLLAAASMGHAS---- 795
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+V L G G+T L +A + G +++V+ LL G D N +DD G T L A
Sbjct: 796 -VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH I + L+ Q G + DNDG +A + GH D +L
Sbjct: 855 AFEGHRLICEALIEQ-GARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 61.6 bits (148), Expect = 5e-09
Identities = 47/167 (28%), Positives = 86/167 (51%), Gaps = 9/167 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D +G L+ + + + L+ + NV+ + G T + ++ + M
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLE-NGANVEASDAEGRTALHVSCW-----QGHM 992
Query: 1215 RIVEELFGC-GDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+V+ L DVNA A ++AL A G + +V+ L+ GA V+ ++G+TAL
Sbjct: 993 EMVQVLIAYHADVNA-ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A++ GH+++V++LL + G + + D G TA+ +A + GH I LL
Sbjct: 1052 AAQEGHIDVVQVLL-EHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/121 (36%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 1207 AVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDE 1266
A+E E +R + L VN + G+T L A G +D+V L++ GAD+ I+D
Sbjct: 521 ALEREDSIRTL--LDNGASVN-QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH 577
Query: 1267 GSTALMCASEHGHVEIVKLLLAQPGCNGHLE--DNDGSTALSIALEAGHKD-IAVLLYAH 1323
G T L A+ GH ++V L+ GC ++ D DG TAL A GH + ++ LLYA
Sbjct: 578 GHTPLTLAARQGHTKVVNCLI---GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Query: 1324 V 1324
V
Sbjct: 635 V 635
Score = 59.7 bits (143), Expect = 2e-08
Identities = 53/169 (31%), Positives = 78/169 (46%), Gaps = 16/169 (9%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLD--ADVCNVDHQNKAGYTPIMLAALAAVEAEK 1212
++ AD + TAL + + +IV LL A+V D++ + AL A
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRT--------ALIAAAYMG 688
Query: 1213 DMRIVEELFGCGDVNAKASQAGQTALMLAV-----SHGRIDMVKGLLACGADVNIQDDEG 1267
IVE L G G+TAL +A S G +V L+ GA+V+ D +G
Sbjct: 689 HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 1268 STALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDI 1316
T L+ A+ GHV++V LLL + G + DN+G T L A GH +
Sbjct: 749 MTPLLVAAYEGHVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASV 796
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 77.4 bits (189), Expect = 9e-14
Identities = 67/251 (26%), Positives = 118/251 (47%), Gaps = 16/251 (6%)
Query: 1075 EKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLN--TLQHEWFRVSSQKSAI 1132
+K R++++ S +++S C L + L+ +M + TL E V K+ I
Sbjct: 297 KKFAARKKWKQSVRLISLCQRLSRSF-----LSRSNMSVARSDDTLDEEDSFV--MKAII 349
Query: 1133 PAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQ 1192
A+ D + + + + Y +N + +G L + N +I++LL+ +D Q
Sbjct: 350 HAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRG-SRIDVQ 408
Query: 1193 NKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKG 1252
+K G + AA ++ + E DV K+ G+ AL +A +G D+ +
Sbjct: 409 DKGGSNAVYWAARHG--HVDTLKFLSENKCPLDVKDKS---GEMALHVAARYGHADVAQL 463
Query: 1253 LLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAG 1312
L + G++ NIQD E T L CA+ HG+ + K L + GCN ++++ +G T L A G
Sbjct: 464 LCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK-ALCEAGCNVNIKNREGETPLLTASARG 522
Query: 1313 HKDIAVLLYAH 1323
+ DI L H
Sbjct: 523 YHDIVECLAEH 533
Score = 67.0 bits (162), Expect = 1e-10
Identities = 52/167 (31%), Positives = 87/167 (52%), Gaps = 9/167 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+++ D +G ALH + + + ++ +LL N + Q+K TP+ AA +
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFG-SNPNIQDKEEETPLHCAAWHGYYS---- 492
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ + L G +VN K ++ G+T L+ A + G D+V+ L GAD+N D +G AL
Sbjct: 493 -VAKALCEAGCNVNIK-NREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHL 550
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
A +E++K LL+Q GC +D G+T L +A + G+ I V L
Sbjct: 551 AVRRCQMEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVAL 596
Score = 59.7 bits (143), Expect = 2e-08
Identities = 42/132 (31%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D +G+ ALH +V E++K LL C VD+Q++ G TP+ +A + +M
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQG-CFVDYQDRHGNTPLHVAC-----KDGNM 590
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
IV L +++ G+T L LA ++G +D+V+ L GA V +G TA A
Sbjct: 591 PIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Query: 1275 SEHGHVEIVKLL 1286
H + LL
Sbjct: 651 RSEQHEHVAGLL 662
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 77.4 bits (189), Expect = 9e-14
Identities = 53/163 (32%), Positives = 86/163 (52%), Gaps = 5/163 (3%)
Query: 1158 ADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIV 1217
AD +G TALH++ + + V+LLL+ +V N ++P+ A + E +M I
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN--AFSPLHCAVINDNEGAAEMLI- 808
Query: 1218 EELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEH 1277
+ G VNA S+ G+T L A ++ ++ LL+ A VN D G T LM A+E+
Sbjct: 809 -DTLGASIVNATDSK-GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAEN 866
Query: 1278 GHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
G V++L++ L+DN +TAL +A GH+ A+L+
Sbjct: 867 GQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
Score = 64.3 bits (155), Expect = 8e-10
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 9/159 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D T LH +V+ + E V++LL +V+ ++K TP+ +AA A K +
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSA-DVNARDKNWQTPLHIAA-----ANKAV 120
Query: 1215 RIVEELFGC-GDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ E L +VN + +AG+TAL A G +MVK LL+ GA++N D + A+
Sbjct: 121 KCAEALVPLLSNVNV-SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAG 1312
A+ GH+E+VKLL++ G +D T L A +G
Sbjct: 180 AAYMGHIEVVKLLVSH-GAEVTCKDKKSYTPLHAAASSG 217
Score = 62.8 bits (151), Expect = 2e-09
Identities = 50/173 (28%), Positives = 85/173 (49%), Gaps = 14/173 (8%)
Query: 1150 VLRYVINLA------DGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLA 1203
V++Y+++L + GNT LH + + +V L+D V+ +N+ G+TP+ A
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI-VNQKNEKGFTPLHFA 279
Query: 1204 ALAAVEAEKDMRIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI 1262
A + A +E L G G DVN K S+ G+T L + HGR + ++ GA ++
Sbjct: 280 AASTHGA----LCLELLVGNGADVNMK-SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDC 334
Query: 1263 QDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKD 1315
+D G+T L A+ +GH ++ L+ G + G L +A +G D
Sbjct: 335 EDKNGNTPLHIAARYGHELLINTLITS-GADTAKRGIHGMFPLHLAALSGFSD 386
Score = 62.0 bits (149), Expect = 4e-09
Identities = 50/169 (29%), Positives = 87/169 (51%), Gaps = 7/169 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D T LH + + EI++LL+ V+ ++ TP+ A + +E+ +
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLI-LSGARVNAKDSKWLTPLHRAVASC--SEEAV 90
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+++ L DVNA+ + QT L +A ++ + + L+ ++VN+ D G TAL A
Sbjct: 91 QVL--LKHSADVNAR-DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ GH E+VKLLL++ G N + D A+ A GH ++ LL +H
Sbjct: 148 AFSGHGEMVKLLLSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Score = 60.5 bits (145), Expect = 1e-08
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 7/154 (4%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N+ +G T LH + H F + ++ + +D ++K G TP+ +AA E
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHEL---- 353
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ L G AK G L LA G D + LL+ G D++ DD G T L A
Sbjct: 354 -LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIA 1308
+ G++E + LLL G + + +D G + L A
Sbjct: 413 AAGGNLECLNLLL-NTGADFNKKDKFGRSPLHYA 445
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/151 (29%), Positives = 75/151 (49%), Gaps = 6/151 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
IN D A+H++ + E+VKLL+ V ++K YTP+ AA + + +
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA-EVTCKDKKSYTPLHAAASSGM-----I 219
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
+V+ L G + + G T L +A +G+ +V L+ CGA VN ++++G T L A
Sbjct: 220 SVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTAL 1305
+ H + LL G + +++ DG T L
Sbjct: 280 AASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Score = 55.8 bits (133), Expect = 3e-07
Identities = 54/173 (31%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 1164 TALHYSVSHSNFEIVKLLL-DADVCN-VDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
T +H + ++ + E ++LL+ +A+ N VD Q+ G TP+ML+ L V L
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG-----HTDCVYSLL 673
Query: 1222 GCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G +V+AK + G+TAL G + V LL GA ++D G T + ++ GH+
Sbjct: 674 NKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHI 732
Query: 1281 EIVKLLL---AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQ 1330
++ LL A N DN G TAL A GH+ LL F K +
Sbjct: 733 GVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
Score = 50.8 bits (120), Expect = 9e-06
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 11/162 (6%)
Query: 1166 LHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG- 1224
LH + H + + +++L+ + + ++D +N +G TP+ LAA + V+ L G
Sbjct: 554 LHLAAYHGHHQALEVLVQS-LLDLDVRNSSGRTPLDLAAFKG-----HVECVDVLINQGA 607
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGAD---VNIQDDEGSTALMCASEHGHVE 1281
+ K +T + A ++G + ++ L+ V+IQD G T LM + +GH +
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
V LL G N +D G TAL GH++ L H
Sbjct: 668 CVYSLL-NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQH 708
Score = 50.8 bits (120), Expect = 9e-06
Identities = 43/139 (30%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+++ DGNG T L SV + + + V LL+ NVD ++K G T + A+ E
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG-ANVDAKDKWGRTALHRGAVTGHE----- 699
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQ----DDEGSTA 1270
V+ L G G+T + L+ + G I ++ LL A ++ D+ G TA
Sbjct: 700 ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759
Query: 1271 LMCASEHGHVEIVKLLLAQ 1289
L A +GH V+LLL Q
Sbjct: 760 LHWACYNGHETCVELLLEQ 778
Score = 49.3 bits (116), Expect = 3e-05
Identities = 49/205 (23%), Positives = 87/205 (42%), Gaps = 45/205 (21%)
Query: 1155 INLADGNGNTALHYSV-SHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAA-------LA 1206
+N D G T LHY+ S ++ + ++ LL D N ++K GY + +A L
Sbjct: 464 VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-NPGIRDKQGYNAVHYSAAYGHRLCLQ 522
Query: 1207 AVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDE 1266
+ +E + ++ E G ++ ++A + L LA HG ++ L+ D+++++
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582
Query: 1267 GSTALMCASEHGHVEIVKLLLAQ------------------PGCNGH------------- 1295
G T L A+ GHVE V +L+ Q NGH
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
Query: 1296 -----LEDNDGSTALSIALEAGHKD 1315
++D +G T L +++ GH D
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTD 667
Score = 47.8 bits (112), Expect = 7e-05
Identities = 53/208 (25%), Positives = 90/208 (43%), Gaps = 39/208 (18%)
Query: 1118 LQHEWFRVSSQKSAIP---AMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSN 1174
L+ E F+ + + P A++ D A E + + ++N D G T LH + +
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 1175 FEIVKLLLDADVCNVDHQNKAGYTPIMLAA-----------LAAVEAEKDMR-------- 1215
E ++LLL + V+ + G TP+M+AA +++ AE ++
Sbjct: 836 VECLQLLLSHN-AQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 1216 --------------IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
I+E++ +NA + A QT L +A +G +V+ LL GA V
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINA-TNAALQTPLHVAARNGLTMVVQELLGKGASVL 953
Query: 1262 IQDDEGST-ALMCASEHGHVEIVKLLLA 1288
D+ G T AL CA + + L+LA
Sbjct: 954 AVDENGYTPALACAPNKDVADCLALILA 981
Score = 41.6 bits (96), Expect = 0.005
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 1235 QTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNG 1294
Q +L+ A+ +G D V+ L+ DVN QD+E T L A+ G EI++LL+ G
Sbjct: 9 QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARV 67
Query: 1295 HLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ +D+ T L A+ + ++ +L H
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 7/155 (4%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
VI+ D NGNT LH + + + ++ L+ + + + G P+ LAAL+
Sbjct: 331 VIDCEDKNGNTPLHIAARYGHELLINTLITSGA-DTAKRGIHGMFPLHLAALSGFSD--- 386
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+L G G+T L A + G ++ + LL GAD N +D G + L
Sbjct: 387 --CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHY 444
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIA 1308
A+ + + + + L+ G + + D G T L A
Sbjct: 445 AAANCNYQCLFALVGS-GASVNDLDERGCTPLHYA 478
Score = 41.2 bits (95), Expect = 0.007
Identities = 44/134 (32%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 1188 NVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGD-VNAKASQAGQTALMLAVSHGR 1246
+V+ Q+ TP+ AA D I+E L G VNAK S+ T L AV+
Sbjct: 33 DVNFQDNEKRTPLHAAAYLG-----DAEIIELLILSGARVNAKDSK-WLTPLHRAVASCS 86
Query: 1247 IDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALS 1306
+ V+ LL ADVN +D T L A+ + V+ + L+ N ++ D G TAL
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS-NVNVSDRAGRTALH 145
Query: 1307 IALEAGHKDIAVLL 1320
A +GH ++ LL
Sbjct: 146 HAAFSGHGEMVKLL 159
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 77.4 bits (189), Expect = 9e-14
Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 11/165 (6%)
Query: 1176 EIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQ 1235
E +K +D + CN + N AL E + +V+EL G G A++ G
Sbjct: 28 EYLKGGIDINTCNQNGLN----------ALHLAAKEGHVGLVQELLGRGSSVDSATKKGN 77
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
TAL +A G+ ++VK L+ GA++N Q G T L A++ H+++VK LL + G N
Sbjct: 78 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQS 136
Query: 1296 LEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRK 1340
DG T L++AL+ GH +L + K + P RK
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N+ G T LH + + ++V LLLD N+ K+G T + LAA E +
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA-----QEDKVN 688
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G ++ G T L++A +G + MV LL GA+VN + G T L A+
Sbjct: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGH 1313
+ GH I+ +LL Q G + +G+TAL+IA G+
Sbjct: 749 QQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 785
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 7/168 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
+LA G T LH + + + ++ KLLL D K G TP+ +AA + +
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPLHVAA-----HYDNQK 589
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ L G ++ G T L +A ++ + LL GA+ NI +G T L AS
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ GH ++V LLL G N H+ G T+L +A + ++A +L H
Sbjct: 650 QEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/199 (29%), Positives = 90/199 (45%), Gaps = 12/199 (6%)
Query: 1152 RYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAE 1211
R + A NG T LH + + N ++ LLL+ + K GYTP+ +AA +
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAA-----KK 618
Query: 1212 KDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTAL 1271
M+I L G ++ G T L LA G DMV LL GA++++ G T+L
Sbjct: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
Query: 1272 MCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAK 1328
A++ V + +L + G + G T L +A G+ + L A+VN AK
Sbjct: 679 HLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AK 736
Query: 1329 AQSPGTPRLGRKTSPGPTH 1347
++ TP L + G TH
Sbjct: 737 TKNGYTP-LHQAAQQGHTH 754
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 8/174 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + + ++++LL+ ++ ++G TPI +AA + IV L
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMG-----HLNIVLLL 429
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G+TAL +A G++++V+ LL GA V+ + E T L AS G
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 489
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
EIV+LLL Q + +G T L I+ G D+A VLL A + A G
Sbjct: 490 EIVQLLL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 15/167 (8%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNK--------AGYTPIMLAALAAVEAEKDMRI 1216
ALH + + + LLL D N D Q+K +G+TP+ +AA ++ +
Sbjct: 174 ALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLHIAAHYG-----NVNV 227
Query: 1217 VEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASE 1276
L G ++ G T L +A G +MVK LL G ++ + +G T L CA+
Sbjct: 228 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287
Query: 1277 HGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
GH ++V+LLL + G +G + L +A + H + L H
Sbjct: 288 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Score = 53.1 bits (126), Expect = 2e-06
Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + N +VKLLLD +D + + G TP+ AA + + ++VE L
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHD-----QVVELL 297
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ G + L +A ++ VK LL A V+ + TAL A+ GH
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ KLLL N + +G T L IA + + LL
Sbjct: 358 RVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVMELL 396
Score = 52.4 bits (124), Expect = 3e-06
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 23/176 (13%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ A GNTALH + E+VK+L+ + N++ Q++ G+TP+ +AA E +
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAA-----QENHI 122
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI----------QD 1264
+V+ L G + A++ G T L +A+ G V LL + +D
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 182
Query: 1265 DEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
D S AL+ ++H K+++ + G T L IA G+ ++A LL
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMV-------NRTTESGFTPLHIAAHYGNVNVATLL 231
Score = 51.6 bits (122), Expect = 5e-06
Identities = 54/199 (27%), Positives = 86/199 (43%), Gaps = 17/199 (8%)
Query: 1124 RVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLD 1183
R KSA + D+ A ++ + ++N +G T LH + + N + LLL+
Sbjct: 180 RKDDTKSAALLLQNDHNADVQS------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 1184 ADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVS 1243
VD + G TP+ +A+ + +V+ L G ++ G T L A
Sbjct: 234 RGAA-VDFTARNGITPLHVAS-----KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287
Query: 1244 HGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED--NDG 1301
G +V+ LL GA + + G + L A++ HVE VK LL ++D D
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KAPVDDVTLDY 344
Query: 1302 STALSIALEAGHKDIAVLL 1320
TAL +A GH + LL
Sbjct: 345 LTALHVAAHCGHYRVTKLL 363
Score = 47.8 bits (112), Expect = 7e-05
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
I+++ +G T+LH + + +L + D K GYTP+++A ++
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYG-----NV 720
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
++V L G +VNAK G T L A G ++ LL GA N G+TAL
Sbjct: 721 KMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 779
Query: 1274 ASEHGHVEIVKLL 1286
A G++ +V L
Sbjct: 780 AKRLGYISVVDTL 792
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 1237 ALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHL 1296
+ + A G +D V L G D+N + G AL A++ GHV +V+ LL + G +
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDS 71
Query: 1297 EDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
G+TAL IA AG ++ +L A++N A++Q+ TP
Sbjct: 72 ATKKGNTALHIASLAGQAEVVKVLVKEGANIN-AQSQNGFTP 112
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 77.4 bits (189), Expect = 9e-14
Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 11/165 (6%)
Query: 1176 EIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQ 1235
E +K +D + CN + N AL E + +V+EL G G A++ G
Sbjct: 49 EYLKGGIDINTCNQNGLN----------ALHLAAKEGHVGLVQELLGRGSSVDSATKKGN 98
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
TAL +A G+ ++VK L+ GA++N Q G T L A++ H+++VK LL + G N
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQS 157
Query: 1296 LEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRK 1340
DG T L++AL+ GH +L + K + P RK
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N+ G T LH + + ++V LLLD N+ K+G T + LAA E +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA-----QEDKVN 709
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G ++ G T L++A +G + MV LL GA+VN + G T L A+
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGH 1313
+ GH I+ +LL Q G + +G+TAL+IA G+
Sbjct: 770 QQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 7/168 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
+LA G T LH + + + ++ KLLL D K G TP+ +AA + +
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPLHVAA-----HYDNQK 610
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ L G ++ G T L +A ++ + LL GA+ NI +G T L AS
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ GH ++V LLL G N H+ G T+L +A + ++A +L H
Sbjct: 671 QEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/199 (29%), Positives = 90/199 (45%), Gaps = 12/199 (6%)
Query: 1152 RYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAE 1211
R + A NG T LH + + N ++ LLL+ + K GYTP+ +AA +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAA-----KK 639
Query: 1212 KDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTAL 1271
M+I L G ++ G T L LA G DMV LL GA++++ G T+L
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 1272 MCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAK 1328
A++ V + +L + G + G T L +A G+ + L A+VN AK
Sbjct: 700 HLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AK 757
Query: 1329 AQSPGTPRLGRKTSPGPTH 1347
++ TP L + G TH
Sbjct: 758 TKNGYTP-LHQAAQQGHTH 775
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 8/174 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + + ++++LL+ ++ ++G TPI +AA + IV L
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMG-----HLNIVLLL 450
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G+TAL +A G++++V+ LL GA V+ + E T L AS G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
EIV+LLL Q + +G T L I+ G D+A VLL A + A G
Sbjct: 511 EIVQLLL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 15/167 (8%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNK--------AGYTPIMLAALAAVEAEKDMRI 1216
ALH + + + LLL D N D Q+K +G+TP+ +AA ++ +
Sbjct: 195 ALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLHIAAHYG-----NVNV 248
Query: 1217 VEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASE 1276
L G ++ G T L +A G +MVK LL G ++ + +G T L CA+
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 1277 HGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
GH ++V+LLL + G +G + L +A + H + L H
Sbjct: 309 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 53.1 bits (126), Expect = 2e-06
Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + N +VKLLLD +D + + G TP+ AA + + ++VE L
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHD-----QVVELL 318
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ G + L +A ++ VK LL A V+ + TAL A+ GH
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ KLLL N + +G T L IA + + LL
Sbjct: 379 RVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Score = 52.4 bits (124), Expect = 3e-06
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 23/176 (13%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ A GNTALH + E+VK+L+ + N++ Q++ G+TP+ +AA E +
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAA-----QENHI 143
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI----------QD 1264
+V+ L G + A++ G T L +A+ G V LL + +D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 1265 DEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
D S AL+ ++H K+++ + G T L IA G+ ++A LL
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMV-------NRTTESGFTPLHIAAHYGNVNVATLL 252
Score = 51.6 bits (122), Expect = 5e-06
Identities = 54/199 (27%), Positives = 86/199 (43%), Gaps = 17/199 (8%)
Query: 1124 RVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLD 1183
R KSA + D+ A ++ + ++N +G T LH + + N + LLL+
Sbjct: 201 RKDDTKSAALLLQNDHNADVQS------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 1184 ADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVS 1243
VD + G TP+ +A+ + +V+ L G ++ G T L A
Sbjct: 255 RGAA-VDFTARNGITPLHVAS-----KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 1244 HGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED--NDG 1301
G +V+ LL GA + + G + L A++ HVE VK LL ++D D
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KAPVDDVTLDY 365
Query: 1302 STALSIALEAGHKDIAVLL 1320
TAL +A GH + LL
Sbjct: 366 LTALHVAAHCGHYRVTKLL 384
Score = 47.8 bits (112), Expect = 7e-05
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
I+++ +G T+LH + + +L + D K GYTP+++A ++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYG-----NV 741
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
++V L G +VNAK G T L A G ++ LL GA N G+TAL
Sbjct: 742 KMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Query: 1274 ASEHGHVEIVKLL 1286
A G++ +V L
Sbjct: 801 AKRLGYISVVDTL 813
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 1237 ALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHL 1296
+ + A G +D V L G D+N + G AL A++ GHV +V+ LL + G +
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDS 92
Query: 1297 EDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
G+TAL IA AG ++ +L A++N A++Q+ TP
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANIN-AQSQNGFTP 133
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 77.4 bits (189), Expect = 9e-14
Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 11/165 (6%)
Query: 1176 EIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQ 1235
E +K +D + CN + N AL E + +V+EL G G A++ G
Sbjct: 49 EYLKGGIDINTCNQNGLN----------ALHLAAKEGHVGLVQELLGRGSSVDSATKKGN 98
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
TAL +A G+ ++VK L+ GA++N Q G T L A++ H+++VK LL + G N
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQS 157
Query: 1296 LEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRK 1340
DG T L++AL+ GH +L + K + P RK
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N+ G T LH + + ++V LLLD N+ K+G T + LAA E +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA-----QEDKVN 709
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G ++ G T L++A +G + MV LL GA+VN + G T L A+
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGH 1313
+ GH I+ +LL Q G + +G+TAL+IA G+
Sbjct: 770 QQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 7/168 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
+LA G T LH + + + ++ KLLL D K G TP+ +AA + +
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA-ADSAGKNGLTPLHVAA-----HYDNQK 610
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ L G ++ G T L +A ++ + LL GA+ NI +G T L AS
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+ GH ++V LLL G N H+ G T+L +A + ++A +L H
Sbjct: 671 QEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/199 (29%), Positives = 90/199 (45%), Gaps = 12/199 (6%)
Query: 1152 RYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAE 1211
R + A NG T LH + + N ++ LLL+ + K GYTP+ +AA +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAA-----KK 639
Query: 1212 KDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTAL 1271
M+I L G ++ G T L LA G DMV LL GA++++ G T+L
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 1272 MCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAK 1328
A++ V + +L + G + G T L +A G+ + L A+VN AK
Sbjct: 700 HLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AK 757
Query: 1329 AQSPGTPRLGRKTSPGPTH 1347
++ TP L + G TH
Sbjct: 758 TKNGYTP-LHQAAQQGHTH 775
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 8/174 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + + ++++LL+ ++ ++G TPI +AA + IV L
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMG-----HLNIVLLL 450
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G+TAL +A G++++V+ LL GA V+ + E T L AS G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA-VLLYAHVNFAKAQSPG 1333
EIV+LLL Q + +G T L I+ G D+A VLL A + A G
Sbjct: 511 EIVQLLL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 15/167 (8%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNK--------AGYTPIMLAALAAVEAEKDMRI 1216
ALH + + + LLL D N D Q+K +G+TP+ +AA ++ +
Sbjct: 195 ALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLHIAAHYG-----NVNV 248
Query: 1217 VEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASE 1276
L G ++ G T L +A G +MVK LL G ++ + +G T L CA+
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 1277 HGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
GH ++V+LLL + G +G + L +A + H + L H
Sbjct: 309 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 53.1 bits (126), Expect = 2e-06
Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + N +VKLLLD +D + + G TP+ AA + + ++VE L
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHD-----QVVELL 318
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ G + L +A ++ VK LL A V+ + TAL A+ GH
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ KLLL N + +G T L IA + + LL
Sbjct: 379 RVTKLLL-DKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Score = 52.4 bits (124), Expect = 3e-06
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 23/176 (13%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
++ A GNTALH + E+VK+L+ + N++ Q++ G+TP+ +AA E +
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAA-----QENHI 143
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNI----------QD 1264
+V+ L G + A++ G T L +A+ G V LL + +D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 1265 DEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
D S AL+ ++H K+++ + G T L IA G+ ++A LL
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMV-------NRTTESGFTPLHIAAHYGNVNVATLL 252
Score = 51.6 bits (122), Expect = 5e-06
Identities = 54/199 (27%), Positives = 86/199 (43%), Gaps = 17/199 (8%)
Query: 1124 RVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLD 1183
R KSA + D+ A ++ + ++N +G T LH + + N + LLL+
Sbjct: 201 RKDDTKSAALLLQNDHNADVQS------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 1184 ADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVS 1243
VD + G TP+ +A+ + +V+ L G ++ G T L A
Sbjct: 255 RGAA-VDFTARNGITPLHVAS-----KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 1244 HGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLED--NDG 1301
G +V+ LL GA + + G + L A++ HVE VK LL ++D D
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---KAPVDDVTLDY 365
Query: 1302 STALSIALEAGHKDIAVLL 1320
TAL +A GH + LL
Sbjct: 366 LTALHVAAHCGHYRVTKLL 384
Score = 47.8 bits (112), Expect = 7e-05
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
I+++ +G T+LH + + +L + D K GYTP+++A ++
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVACHYG-----NV 741
Query: 1215 RIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
++V L G +VNAK G T L A G ++ LL GA N G+TAL
Sbjct: 742 KMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Query: 1274 ASEHGHVEIVKLL 1286
A G++ +V L
Sbjct: 801 AKRLGYISVVDTL 813
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 1237 ALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHL 1296
+ + A G +D V L G D+N + G AL A++ GHV +V+ LL + G +
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDS 92
Query: 1297 EDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
G+TAL IA AG ++ +L A++N A++Q+ TP
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANIN-AQSQNGFTP 133
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 74.7 bits (182), Expect = 6e-13
Identities = 59/188 (31%), Positives = 94/188 (50%), Gaps = 14/188 (7%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N D +G +ALH++ + N E++ LLL+A VD ++ G P+ AA ++ M
Sbjct: 42 VNFQDPDGFSALHHAALNGNTELISLLLEAQAA-VDIKDNKGMRPLHYAAWQG--RKEPM 98
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++V + G S G L LA HG D+ + LL ++ + D+ G T L A
Sbjct: 99 KLVLK---AGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA 155
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLE-------DNDGSTALSIALEAGHKD-IAVLLYAHVNF 1326
E G V +V+LLL+ C LE D +G++ L +A + GH D I +LL A ++
Sbjct: 156 CEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDI 215
Query: 1327 AKAQSPGT 1334
+ GT
Sbjct: 216 NRQTKSGT 223
Score = 35.8 bits (81), Expect = 0.29
Identities = 32/123 (26%), Positives = 56/123 (45%), Gaps = 15/123 (12%)
Query: 1157 LADGNGNTALHYSVSHSNFEIVKLLLDADVCNV-------DHQNKAGYTPIMLAALAAVE 1209
+ D +G T L + +V+LLL +++C D + G +P+ LAA
Sbjct: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAA----- 197
Query: 1210 AEKDMRIVEELFGCG-DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGS 1268
+ I+ L G D+N + TAL A G+ ++V+ LL G + ++++
Sbjct: 198 KNGHIDIIRLLLQAGIDINRQTKSG--TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQ 255
Query: 1269 TAL 1271
TAL
Sbjct: 256 TAL 258
Score = 34.3 bits (77), Expect = 0.83
Identities = 22/58 (37%), Positives = 34/58 (58%), Gaps = 3/58 (5%)
Query: 1259 DVNIQDDEGSTALMCASEHGHVEIVKLLL-AQPGCNGHLEDNDGSTALSIALEAGHKD 1315
+VN QD +G +AL A+ +G+ E++ LLL AQ + ++DN G L A G K+
Sbjct: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVD--IKDNKGMRPLHYAAWQGRKE 96
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapiens]
Length = 313
Score = 74.7 bits (182), Expect = 6e-13
Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 6/136 (4%)
Query: 1189 VDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRID 1248
++H ++ G+TP+M AA A + +VE L G + ++AL LA S G D
Sbjct: 175 INHTDEEGFTPLMWAA-----AHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTD 229
Query: 1249 MVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIA 1308
+VK LL CG DVN D G T L+ A HV+ VK+LL + G + +E + G ++ +A
Sbjct: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLL-ESGADPTIETDSGYNSMDLA 288
Query: 1309 LEAGHKDIAVLLYAHV 1324
+ G++ + ++ +H+
Sbjct: 289 VALGYRSVQQVIESHL 304
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 73.6 bits (179), Expect = 1e-12
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 11/165 (6%)
Query: 1176 EIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQ 1235
+ +K +D ++CN + N AL E + +V EL A++ G
Sbjct: 59 DYIKNGVDINICNQNGLN----------ALHLASKEGHVEVVSELLQREANVDAATKKGN 108
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
TAL +A G+ ++VK L+ GA+VN Q G T L A++ H+E+VK LL G +
Sbjct: 109 TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL-DNGASQS 167
Query: 1296 LEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRK 1340
L DG T L++AL+ GH + LL + K + P RK
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212
Score = 66.6 bits (161), Expect = 2e-10
Identities = 49/174 (28%), Positives = 84/174 (48%), Gaps = 10/174 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+++ G T LH + + E+ LLL + D K+G TP+ +AA +
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSA-SPDAAGKSGLTPLHVAA-----HYDNQ 611
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
++ L G A++ G T L +A ++D+ LL GAD N +G ++ A
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVN 1325
++ GHV++V LLL + N +L + G T L +A + ++A +L AHV+
Sbjct: 672 AQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Score = 61.2 bits (147), Expect = 6e-09
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N + G TALH + E+V+ L+ D V+ + K TP+ ++A
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQ-DGAQVEAKAKDDQTPLHISARLG-----KAD 513
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
IV++L G A+ +G T L L+ G D+ LL GA ++I +G T L A+
Sbjct: 514 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
++G +E+ LLL Q + G T L +A ++ +A+LL
Sbjct: 574 KYGKLEVANLLL-QKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Score = 60.8 bits (146), Expect = 8e-09
Identities = 43/153 (28%), Positives = 75/153 (49%), Gaps = 7/153 (4%)
Query: 1164 TALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGC 1223
TALH + ++++ K+LLD N + + G+TP+ +A + ++++E L
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIAC-----KKNRIKVMELLLKH 422
Query: 1224 GDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIV 1283
G +++G T + +A G +++V L+ GA N + G TAL A+ G E+V
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Query: 1284 KLLLAQPGCNGHLEDNDGSTALSIALEAGHKDI 1316
+ L+ Q G + D T L I+ G DI
Sbjct: 483 RYLV-QDGAQVEAKAKDDQTPLHISARLGKADI 514
Score = 54.7 bits (130), Expect = 6e-07
Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 26/190 (13%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA------- 1207
+N NG T L+ + ++ E+VK LLD + + + G+TP+ +A
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLD-NGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 1208 ----------------VEAEKDMRIVEELFGCGDVNAKA-SQAGQTALMLAVSHGRIDMV 1250
+ A KD L D NA S++G T L +A +G I++
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 1251 KGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALE 1310
LL A V+ T L AS+ G+ +VKLLL + G + DG T L
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGAR 310
Query: 1311 AGHKDIAVLL 1320
+GH+ + +L
Sbjct: 311 SGHEQVVEML 320
Score = 54.7 bits (130), Expect = 6e-07
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 11/161 (6%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + LLL D N D ++K+G+TP+ +AA ++ + L
Sbjct: 205 ALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYG-----NINVATLLLNRA 258
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
++ T L +A G +MVK LL GA ++ + +G T L C + GH ++V+
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
Query: 1285 LLL--AQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+LL A P + + +G + L +A + H + LL H
Sbjct: 319 MLLDRAAPILS---KTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 50.4 bits (119), Expect = 1e-05
Identities = 45/163 (27%), Positives = 74/163 (45%), Gaps = 7/163 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
N T LH + N +VKLLLD +D + + G TP+ A + E ++VE L
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGA-KIDAKTRDGLTPLHCGARSGHE-----QVVEML 320
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
++ G + L +A ++ V+ LL V+ ++ TAL A+ GH
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHY 380
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
++ K+LL + N + + +G T L IA + + LL H
Sbjct: 381 KVAKVLLDKK-ANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Score = 48.9 bits (115), Expect = 3e-05
Identities = 37/110 (33%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 1229 KASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLA 1288
K + + A G ++ + G D+NI + G AL AS+ GHVE+V LL
Sbjct: 36 KKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL- 94
Query: 1289 QPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
Q N G+TAL IA AG ++ +L A+VN A++Q+ TP
Sbjct: 95 QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN-AQSQNGFTP 143
Score = 48.1 bits (113), Expect = 6e-05
Identities = 50/187 (26%), Positives = 81/187 (43%), Gaps = 15/187 (8%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
+G T +H + + IV L+ + + N G T + +AA + +AE +V++
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGA-SPNTTNVRGETALHMAARSG-QAEVVRYLVQD- 488
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
V AKA QT L ++ G+ D+V+ LL GA N G T L ++ GH
Sbjct: 489 --GAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRK 1340
++ LL G + + G T L +A + G ++A LL Q +P K
Sbjct: 546 DVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLL--------LQKSASPDAAGK 596
Query: 1341 TSPGPTH 1347
+ P H
Sbjct: 597 SGLTPLH 603
Score = 48.1 bits (113), Expect = 6e-05
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+NL++ +G T LH + + ++L++ +VD Q K GYTP+ + ++
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHVGCHYG-----NI 743
Query: 1215 RIVEELFG-CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+IV L VNAK G T L A G ++ LL A N G+TAL
Sbjct: 744 KIVNFLLQHSAKVNAKTKN-GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
Query: 1274 ASEHGHVEIVKLL 1286
A G++ +V L
Sbjct: 803 ARRLGYISVVDTL 815
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 73.2 bits (178), Expect = 2e-12
Identities = 51/165 (30%), Positives = 92/165 (55%), Gaps = 6/165 (3%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
NL++ G+T LH +V +V+LLL + +V+ +++ +T + AA E+ +
Sbjct: 465 NLSNRRGSTPLHMAVERRVRGVVELLLARKI-SVNAKDEDQWTALHFAAQNGDESSTRL- 522
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
++E+ +V+ + G+T + +A HG+ ++V+ LL G DV++Q + L A+
Sbjct: 523 LLEKNASVNEVDFE----GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
GH+ IVKLL QPG + + + DG T L +A + GH +A +L
Sbjct: 579 WQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 56.2 bits (134), Expect = 2e-07
Identities = 51/186 (27%), Positives = 83/186 (44%), Gaps = 19/186 (10%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLD----ADVCNVDHQNKAGYTPIMLAALAAVEA 1210
+N +G T LH + ++ + ++L+D +VC++ Q TP+ +AA +
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-----TPLHVAAETGHTS 651
Query: 1211 EKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTA 1270
+ L G + G TAL LA +G + VK L+ ADV + TA
Sbjct: 652 TARL-----LLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA 706
Query: 1271 LMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
L A+ HGH E+V+ L++ + L D G +AL +A + H L AH+N
Sbjct: 707 LHLAAAHGHSEVVEELVSADVID--LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQ 764
Query: 1328 KAQSPG 1333
+ G
Sbjct: 765 SLKFQG 770
Score = 42.4 bits (98), Expect = 0.003
Identities = 42/137 (30%), Positives = 68/137 (49%), Gaps = 11/137 (8%)
Query: 1184 ADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVS 1243
+D+ D Q K ++ A+ + + K M+I++ DV+ A +G + L LAV
Sbjct: 398 SDLGTTDVQKKK-----LVDAIVSGDTSKLMKILQPQ----DVDL-ALDSGASLLHLAVE 447
Query: 1244 HGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGST 1303
G+ + K LL A+ N+ + GST L A E +V+LLLA+ + + +D D T
Sbjct: 448 AGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK-ISVNAKDEDQWT 506
Query: 1304 ALSIALEAGHKDIAVLL 1320
AL A + G + LL
Sbjct: 507 ALHFAAQNGDESSTRLL 523
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 72.4 bits (176), Expect = 3e-12
Identities = 59/191 (30%), Positives = 96/191 (50%), Gaps = 18/191 (9%)
Query: 1143 FEAISPDVLRYVINLADG----------NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQ 1192
F A ++ + ++ L DG N + LH + + +I +L+ A N+D
Sbjct: 744 FSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGA-NIDTC 802
Query: 1193 NKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKG 1252
++ TP+M AA + V+ L G + G T L LA G ++V+
Sbjct: 803 SEDQRTPLMEAA-----ENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQY 857
Query: 1253 LLACGA-DVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEA 1311
LL+ G DVN QDD G T ++ A+E+ HV++VKLLL++ G + ++ DN+ + L A +
Sbjct: 858 LLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK-GSDINIRDNEENICLHWAAFS 916
Query: 1312 GHKDIAVLLYA 1322
G DIA +L A
Sbjct: 917 GCVDIAEILLA 927
Score = 62.0 bits (149), Expect = 4e-09
Identities = 52/167 (31%), Positives = 84/167 (50%), Gaps = 10/167 (5%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
I+ + T L + +++ E VK L+ A VD ++ G T + LAA +
Sbjct: 799 IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL-VDPKDAEGSTCLHLAA-----KKGHY 852
Query: 1215 RIVEELFGCG--DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALM 1272
+V+ L G DVN + G T ++ A + +D+VK LL+ G+D+NI+D+E + L
Sbjct: 853 EVVQYLLSNGQMDVNCQ-DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 911
Query: 1273 CASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVL 1319
A+ G V+I ++LLA C+ H + G + L IA D VL
Sbjct: 912 WAAFSGCVDIAEILLAAK-CDLHAVNIHGDSPLHIAARENRYDCVVL 957
Score = 60.8 bits (146), Expect = 8e-09
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 10/158 (6%)
Query: 1166 LHYSVSHSNFEIVKLLLDADV---CNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFG 1222
L++S + V L+L + ++HQNK +P+ AA A + I L
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAG-----HVDICHMLVQ 794
Query: 1223 CGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEI 1282
G S+ +T LM A + ++ VK L+ GA V+ +D EGST L A++ GH E+
Sbjct: 795 AGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEV 854
Query: 1283 VKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
V+ LL+ + + +D+ G T + A E H D+ LL
Sbjct: 855 VQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
Score = 47.8 bits (112), Expect = 7e-05
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Query: 1232 QAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPG 1291
Q ++ L A G +D+ L+ GA+++ ++ T LM A+E+ H+E VK L+ + G
Sbjct: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-KAG 829
Query: 1292 CNGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1323
+D +GST L +A + GH ++ L ++
Sbjct: 830 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 11/189 (5%)
Query: 1162 GNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
G T LH + + + +LLL+ D + + K G TP+ +A ++ IV+ L
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAV-----HHNNLDIVKLLL 622
Query: 1222 GCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G + G T L +A ++++ + LL G N + +G T L A++ GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT 1341
+V LLL++ NG+L + G T L + + GH +A +L H A T R+G
Sbjct: 683 MVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTP 737
Query: 1342 SPGPTHRGS 1350
+H G+
Sbjct: 738 LHVASHYGN 746
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
Query: 1202 LAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
L L E +++V EL + ++ G TAL +A G+ ++V+ L+ GA+VN
Sbjct: 79 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138
Query: 1262 IQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY 1321
Q +G T L A++ H+E+VK LL + G N ++ DG T L++AL+ GH+++ L
Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197
Query: 1322 AHVNFAKAQSP 1332
+ K + P
Sbjct: 198 NYGTKGKVRLP 208
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N G T LH + + E+V LLL N + NK+G TP+ L A E +
Sbjct: 662 NAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVA-----QEGHVP 715
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G + ++ G T L +A +G I +VK LL ADVN + G + L A+
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH +IV LLL + G + + +DG+T L+IA G+ + +L
Sbjct: 776 QQGHTDIVTLLL-KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 64.3 bits (155), Expect = 8e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + ++ +++LLL ++D ++G TP+ +A+ + IV+ L
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMG-----HLPIVKNL 456
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ +T L +A G ++ K LL A VN + + T L CA+ GH
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+VKLLL + N +L G T L IA GH + + L
Sbjct: 517 NMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
Score = 58.9 bits (141), Expect = 3e-08
Identities = 54/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG + +H + + + V+LLL D +D TP+ +AA R+ + L
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHH-----RVAKVL 390
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G T L +A + +++ LL GA ++ + G T L AS GH+
Sbjct: 391 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 450
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
IVK LL Q G + ++ + T L +A AGH ++A L A VN AKA+ TP
Sbjct: 451 PIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTP 506
Score = 57.8 bits (138), Expect = 7e-08
Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + +LL D N D +K G+TP+ +AA +++ + + L G
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAA-----HYENLNVAQLLLNRG 262
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Q G T L +A G + MV+ LL GA + + + T L CA+ +GHV I +
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+LL G + +G + + +A + H D LL
Sbjct: 323 ILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Score = 57.8 bits (138), Expect = 7e-08
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N + T LH + + +VKLLL+ + N + AG+TP+ +AA E +
Sbjct: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAA-----REGHV 549
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
V L A ++ G T L +A +G++ + + LL A N G T L A
Sbjct: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
H +++IVKLLL + G + H +G T L IA + ++A L + A A+S
Sbjct: 610 VHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/177 (33%), Positives = 77/177 (43%), Gaps = 12/177 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA-VEAEKD 1213
I+ +G T LH + + IVK LL + + N TP+ +AA A E K
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKY 488
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L VNAKA QT L A G +MVK LL A+ N+ G T L
Sbjct: 489 L-----LQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
A+ GHVE V LL + + G T L +A + G +A LL AH N A
Sbjct: 543 AAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 598
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/176 (27%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
++ GNTALH + E+V+ L++ NV+ Q++ G+TP+ +AA E
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAA-----QENH 156
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ +V+ L G A++ G T L +A+ G ++V L+ G ++ AL
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 212
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNF 1326
A+ + +LL Q N + G T L IA + ++A LL A VNF
Sbjct: 213 AARNDDTRTAAVLL-QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267
Score = 39.3 bits (90), Expect = 0.026
Identities = 38/114 (33%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
D KA A T+ + A G +D L G D+N + G L AS+ GHV++V
Sbjct: 38 DRKKKADAA--TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 95
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIA---VLLYAHVNFAKAQSPGTP 1335
LL + G+TAL IA AG ++ V A+VN A++Q TP
Sbjct: 96 ELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTP 147
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 11/189 (5%)
Query: 1162 GNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
G T LH + + + +LLL+ D + + K G TP+ +A ++ IV+ L
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAV-----HHNNLDIVKLLL 589
Query: 1222 GCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G + G T L +A ++++ + LL G N + +G T L A++ GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT 1341
+V LLL++ NG+L + G T L + + GH +A +L H A T R+G
Sbjct: 650 MVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTP 704
Query: 1342 SPGPTHRGS 1350
+H G+
Sbjct: 705 LHVASHYGN 713
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
Query: 1202 LAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
L L E +++V EL + ++ G TAL +A G+ ++V+ L+ GA+VN
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 1262 IQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY 1321
Q +G T L A++ H+E+VK LL + G N ++ DG T L++AL+ GH+++ L
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 1322 AHVNFAKAQSP 1332
+ K + P
Sbjct: 165 NYGTKGKVRLP 175
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N G T LH + + E+V LLL N + NK+G TP+ L A E +
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVA-----QEGHVP 682
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G + ++ G T L +A +G I +VK LL ADVN + G + L A+
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH +IV LLL + G + + +DG+T L+IA G+ + +L
Sbjct: 743 QQGHTDIVTLLL-KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 8e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + ++ +++LLL ++D ++G TP+ +A+ + IV+ L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMG-----HLPIVKNL 423
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ +T L +A G ++ K LL A VN + + T L CA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+VKLLL + N +L G T L IA GH + + L
Sbjct: 484 NMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Score = 58.9 bits (141), Expect = 3e-08
Identities = 54/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG + +H + + + V+LLL D +D TP+ +AA R+ + L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHH-----RVAKVL 357
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G T L +A + +++ LL GA ++ + G T L AS GH+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
IVK LL Q G + ++ + T L +A AGH ++A L A VN AKA+ TP
Sbjct: 418 PIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTP 473
Score = 57.8 bits (138), Expect = 7e-08
Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + +LL D N D +K G+TP+ +AA +++ + + L G
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAA-----HYENLNVAQLLLNRG 229
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Q G T L +A G + MV+ LL GA + + + T L CA+ +GHV I +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+LL G + +G + + +A + H D LL
Sbjct: 290 ILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 57.8 bits (138), Expect = 7e-08
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N + T LH + + +VKLLL+ + N + AG+TP+ +AA E +
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAA-----REGHV 516
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
V L A ++ G T L +A +G++ + + LL A N G T L A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
H +++IVKLLL + G + H +G T L IA + ++A L + A A+S
Sbjct: 577 VHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/177 (33%), Positives = 77/177 (43%), Gaps = 12/177 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA-VEAEKD 1213
I+ +G T LH + + IVK LL + + N TP+ +AA A E K
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L VNAKA QT L A G +MVK LL A+ N+ G T L
Sbjct: 456 L-----LQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
A+ GHVE V LL + + G T L +A + G +A LL AH N A
Sbjct: 510 AAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/176 (27%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
++ GNTALH + E+V+ L++ NV+ Q++ G+TP+ +AA E
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAA-----QENH 123
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ +V+ L G A++ G T L +A+ G ++V L+ G ++ AL
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 179
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNF 1326
A+ + +LL Q N + G T L IA + ++A LL A VNF
Sbjct: 180 AARNDDTRTAAVLL-QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 38.9 bits (89), Expect = 0.034
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
T+ + A G +D L G D+N + G L AS+ GHV++V LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILE 72
Query: 1296 LEDNDGSTALSIALEAGHKDIA---VLLYAHVNFAKAQSPGTP 1335
G+TAL IA AG ++ V A+VN A++Q TP
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTP 114
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 11/189 (5%)
Query: 1162 GNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
G T LH + + + +LLL+ D + + K G TP+ +A ++ IV+ L
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAV-----HHNNLDIVKLLL 589
Query: 1222 GCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G + G T L +A ++++ + LL G N + +G T L A++ GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT 1341
+V LLL++ NG+L + G T L + + GH +A +L H A T R+G
Sbjct: 650 MVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTP 704
Query: 1342 SPGPTHRGS 1350
+H G+
Sbjct: 705 LHVASHYGN 713
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
Query: 1202 LAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
L L E +++V EL + ++ G TAL +A G+ ++V+ L+ GA+VN
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 1262 IQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY 1321
Q +G T L A++ H+E+VK LL + G N ++ DG T L++AL+ GH+++ L
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 1322 AHVNFAKAQSP 1332
+ K + P
Sbjct: 165 NYGTKGKVRLP 175
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N G T LH + + E+V LLL N + NK+G TP+ L A E +
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVA-----QEGHVP 682
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G + ++ G T L +A +G I +VK LL ADVN + G + L A+
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH +IV LLL + G + + +DG+T L+IA G+ + +L
Sbjct: 743 QQGHTDIVTLLL-KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 8e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + ++ +++LLL ++D ++G TP+ +A+ + IV+ L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMG-----HLPIVKNL 423
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ +T L +A G ++ K LL A VN + + T L CA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+VKLLL + N +L G T L IA GH + + L
Sbjct: 484 NMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Score = 58.9 bits (141), Expect = 3e-08
Identities = 54/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG + +H + + + V+LLL D +D TP+ +AA R+ + L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHH-----RVAKVL 357
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G T L +A + +++ LL GA ++ + G T L AS GH+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
IVK LL Q G + ++ + T L +A AGH ++A L A VN AKA+ TP
Sbjct: 418 PIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTP 473
Score = 57.8 bits (138), Expect = 7e-08
Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + +LL D N D +K G+TP+ +AA +++ + + L G
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAA-----HYENLNVAQLLLNRG 229
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Q G T L +A G + MV+ LL GA + + + T L CA+ +GHV I +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+LL G + +G + + +A + H D LL
Sbjct: 290 ILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 57.8 bits (138), Expect = 7e-08
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N + T LH + + +VKLLL+ + N + AG+TP+ +AA E +
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAA-----REGHV 516
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
V L A ++ G T L +A +G++ + + LL A N G T L A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
H +++IVKLLL + G + H +G T L IA + ++A L + A A+S
Sbjct: 577 VHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/177 (33%), Positives = 77/177 (43%), Gaps = 12/177 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA-VEAEKD 1213
I+ +G T LH + + IVK LL + + N TP+ +AA A E K
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L VNAKA QT L A G +MVK LL A+ N+ G T L
Sbjct: 456 L-----LQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
A+ GHVE V LL + + G T L +A + G +A LL AH N A
Sbjct: 510 AAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/176 (27%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
++ GNTALH + E+V+ L++ NV+ Q++ G+TP+ +AA E
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAA-----QENH 123
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ +V+ L G A++ G T L +A+ G ++V L+ G ++ AL
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 179
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNF 1326
A+ + +LL Q N + G T L IA + ++A LL A VNF
Sbjct: 180 AARNDDTRTAAVLL-QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 38.9 bits (89), Expect = 0.034
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
T+ + A G +D L G D+N + G L AS+ GHV++V LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILE 72
Query: 1296 LEDNDGSTALSIALEAGHKDIA---VLLYAHVNFAKAQSPGTP 1335
G+TAL IA AG ++ V A+VN A++Q TP
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTP 114
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 11/189 (5%)
Query: 1162 GNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
G T LH + + + +LLL+ D + + K G TP+ +A ++ IV+ L
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAV-----HHNNLDIVKLLL 589
Query: 1222 GCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G + G T L +A ++++ + LL G N + +G T L A++ GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT 1341
+V LLL++ NG+L + G T L + + GH +A +L H A T R+G
Sbjct: 650 MVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTP 704
Query: 1342 SPGPTHRGS 1350
+H G+
Sbjct: 705 LHVASHYGN 713
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
Query: 1202 LAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
L L E +++V EL + ++ G TAL +A G+ ++V+ L+ GA+VN
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 1262 IQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY 1321
Q +G T L A++ H+E+VK LL + G N ++ DG T L++AL+ GH+++ L
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 1322 AHVNFAKAQSP 1332
+ K + P
Sbjct: 165 NYGTKGKVRLP 175
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N G T LH + + E+V LLL N + NK+G TP+ L A E +
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVA-----QEGHVP 682
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G + ++ G T L +A +G I +VK LL ADVN + G + L A+
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH +IV LLL + G + + +DG+T L+IA G+ + +L
Sbjct: 743 QQGHTDIVTLLL-KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 8e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + ++ +++LLL ++D ++G TP+ +A+ + IV+ L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMG-----HLPIVKNL 423
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ +T L +A G ++ K LL A VN + + T L CA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+VKLLL + N +L G T L IA GH + + L
Sbjct: 484 NMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Score = 58.9 bits (141), Expect = 3e-08
Identities = 54/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG + +H + + + V+LLL D +D TP+ +AA R+ + L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHH-----RVAKVL 357
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G T L +A + +++ LL GA ++ + G T L AS GH+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
IVK LL Q G + ++ + T L +A AGH ++A L A VN AKA+ TP
Sbjct: 418 PIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTP 473
Score = 57.8 bits (138), Expect = 7e-08
Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + +LL D N D +K G+TP+ +AA +++ + + L G
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAA-----HYENLNVAQLLLNRG 229
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Q G T L +A G + MV+ LL GA + + + T L CA+ +GHV I +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+LL G + +G + + +A + H D LL
Sbjct: 290 ILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 57.8 bits (138), Expect = 7e-08
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N + T LH + + +VKLLL+ + N + AG+TP+ +AA E +
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAA-----REGHV 516
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
V L A ++ G T L +A +G++ + + LL A N G T L A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
H +++IVKLLL + G + H +G T L IA + ++A L + A A+S
Sbjct: 577 VHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/177 (33%), Positives = 77/177 (43%), Gaps = 12/177 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA-VEAEKD 1213
I+ +G T LH + + IVK LL + + N TP+ +AA A E K
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L VNAKA QT L A G +MVK LL A+ N+ G T L
Sbjct: 456 L-----LQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
A+ GHVE V LL + + G T L +A + G +A LL AH N A
Sbjct: 510 AAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/176 (27%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
++ GNTALH + E+V+ L++ NV+ Q++ G+TP+ +AA E
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAA-----QENH 123
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ +V+ L G A++ G T L +A+ G ++V L+ G ++ AL
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 179
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNF 1326
A+ + +LL Q N + G T L IA + ++A LL A VNF
Sbjct: 180 AARNDDTRTAAVLL-QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 38.9 bits (89), Expect = 0.034
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
T+ + A G +D L G D+N + G L AS+ GHV++V LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILE 72
Query: 1296 LEDNDGSTALSIALEAGHKDIA---VLLYAHVNFAKAQSPGTP 1335
G+TAL IA AG ++ V A+VN A++Q TP
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTP 114
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 11/189 (5%)
Query: 1162 GNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELF 1221
G T LH + + + +LLL+ D + + K G TP+ +A ++ IV+ L
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAV-----HHNNLDIVKLLL 589
Query: 1222 GCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVE 1281
G + G T L +A ++++ + LL G N + +G T L A++ GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 1282 IVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT 1341
+V LLL++ NG+L + G T L + + GH +A +L H A T R+G
Sbjct: 650 MVALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTP 704
Query: 1342 SPGPTHRGS 1350
+H G+
Sbjct: 705 LHVASHYGN 713
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
Query: 1202 LAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVN 1261
L L E +++V EL + ++ G TAL +A G+ ++V+ L+ GA+VN
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 1262 IQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY 1321
Q +G T L A++ H+E+VK LL + G N ++ DG T L++AL+ GH+++ L
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 1322 AHVNFAKAQSP 1332
+ K + P
Sbjct: 165 NYGTKGKVRLP 175
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 1156 NLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMR 1215
N G T LH + + E+V LLL N + NK+G TP+ L A E +
Sbjct: 629 NAESVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVA-----QEGHVP 682
Query: 1216 IVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCAS 1275
+ + L G + ++ G T L +A +G I +VK LL ADVN + G + L A+
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 1276 EHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+ GH +IV LLL + G + + +DG+T L+IA G+ + +L
Sbjct: 743 QQGHTDIVTLLL-KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 8e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG T LH + ++ +++LLL ++D ++G TP+ +A+ + IV+ L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMG-----HLPIVKNL 423
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G ++ +T L +A G ++ K LL A VN + + T L CA+ GH
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+VKLLL + N +L G T L IA GH + + L
Sbjct: 484 NMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Score = 58.9 bits (141), Expect = 3e-08
Identities = 54/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%)
Query: 1161 NGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEEL 1220
NG + +H + + + V+LLL D +D TP+ +AA R+ + L
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHH-----RVAKVL 357
Query: 1221 FGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHV 1280
G + G T L +A + +++ LL GA ++ + G T L AS GH+
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
Query: 1281 EIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFAKAQSPGTP 1335
IVK LL Q G + ++ + T L +A AGH ++A L A VN AKA+ TP
Sbjct: 418 PIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN-AKAKDDQTP 473
Score = 57.8 bits (138), Expect = 7e-08
Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%)
Query: 1165 ALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCG 1224
ALH + + + +LL D N D +K G+TP+ +AA +++ + + L G
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAA-----HYENLNVAQLLLNRG 229
Query: 1225 DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVK 1284
Q G T L +A G + MV+ LL GA + + + T L CA+ +GHV I +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 1285 LLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1320
+LL G + +G + + +A + H D LL
Sbjct: 290 ILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 57.8 bits (138), Expect = 7e-08
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM 1214
+N + T LH + + +VKLLL+ + N + AG+TP+ +AA E +
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NPNLATTAGHTPLHIAA-----REGHV 516
Query: 1215 RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA 1274
V L A ++ G T L +A +G++ + + LL A N G T L A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Query: 1275 SEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQS 1331
H +++IVKLLL + G + H +G T L IA + ++A L + A A+S
Sbjct: 577 VHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/177 (33%), Positives = 77/177 (43%), Gaps = 12/177 (6%)
Query: 1155 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAA-VEAEKD 1213
I+ +G T LH + + IVK LL + + N TP+ +AA A E K
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ L VNAKA QT L A G +MVK LL A+ N+ G T L
Sbjct: 456 L-----LQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNFA 1327
A+ GHVE V LL + + G T L +A + G +A LL AH N A
Sbjct: 510 AAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/176 (27%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 1154 VINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKD 1213
++ GNTALH + E+V+ L++ NV+ Q++ G+TP+ +AA E
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAA-----QENH 123
Query: 1214 MRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMC 1273
+ +V+ L G A++ G T L +A+ G ++V L+ G ++ AL
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHI 179
Query: 1274 ASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLY---AHVNF 1326
A+ + +LL Q N + G T L IA + ++A LL A VNF
Sbjct: 180 AARNDDTRTAAVLL-QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
Score = 38.9 bits (89), Expect = 0.034
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1236 TALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGH 1295
T+ + A G +D L G D+N + G L AS+ GHV++V LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILE 72
Query: 1296 LEDNDGSTALSIALEAGHKDIA---VLLYAHVNFAKAQSPGTP 1335
G+TAL IA AG ++ V A+VN A++Q TP
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTP 114
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,922,142
Number of Sequences: 37866
Number of extensions: 2398015
Number of successful extensions: 19437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 366
Number of HSP's successfully gapped in prelim test: 501
Number of HSP's that attempted gapping in prelim test: 13185
Number of HSP's gapped (non-prelim): 4194
length of query: 1352
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1238
effective length of database: 13,930,794
effective search space: 17246322972
effective search space used: 17246322972
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.