Search of human proteins with 64368472

Search of human proteins with 64368472

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide
1 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   991   0.0  
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   331   1e-90
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   330   2e-90
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   330   2e-90
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   330   2e-90
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   328   5e-90
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   328   7e-90
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   327   1e-89
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   326   3e-89
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   324   1e-88
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   318   9e-87
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   315   6e-86
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   311   9e-85
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   308   9e-84
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   305   6e-83
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   297   2e-80
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   281   1e-75
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   260   2e-69
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   229   3e-60
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   202   6e-52
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   195   7e-50
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  180   2e-45
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   175   7e-44
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   172   5e-43
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   153   4e-37
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   114   3e-25
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   105   9e-23
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   105   1e-22
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   101   1e-21
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   101   2e-21

>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  991 bits (2561), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELS 60
           MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELS
Sbjct: 1   MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELS 60

Query: 61  ERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGA 120
           ERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGA
Sbjct: 61  ERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGA 120

Query: 121 RWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITF 180
           RWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITF
Sbjct: 121 RWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITF 180

Query: 181 ALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEV 240
           ALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEV
Sbjct: 181 ALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEV 240

Query: 241 RAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTET 300
           RAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTET
Sbjct: 241 RAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTET 300

Query: 301 TSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITL 360
           TSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITL
Sbjct: 301 TSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITL 360

Query: 361 LPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR 420
           LPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR
Sbjct: 361 LPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR 420

Query: 421 EAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPR 480
           EAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPR
Sbjct: 421 EAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPR 480

Query: 481 AQALCAVPRP 490
           AQALCAVPRP
Sbjct: 481 AQALCAVPRP 490


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  331 bits (848), Expect = 1e-90
 Identities = 196/492 (39%), Positives = 292/492 (59%), Gaps = 14/492 (2%)

Query: 4   LLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERY 63
           +LLL L L+ L  LL   ++D     + PPGPRPL ++GNL LL       SL +LS+ Y
Sbjct: 8   ILLLLLALVCL--LLTLSSRDKG---KLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEY 62

Query: 64  GPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWR 123
           G ++TVHLG ++ VVL+G++AVKEAL   G+E + R     F    +G GI FSSG RW+
Sbjct: 63  GSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWK 122

Query: 124 AARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFAL 182
             RQF+++ L + G+G+  + ++IL+E   L  +L    G PF P  +L  + SNI  ++
Sbjct: 123 VLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSV 182

Query: 183 LFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYP-WLGALLQLHRPVLRKIEEVR 241
           LFG RFDY D   ++++ LI++   ++ SP  +L++++P  L  +   H+ + +  + +R
Sbjct: 183 LFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLR 242

Query: 242 AILRTLLEARRPHVCPGDPVCSYVDALIQQ--GQGDDPEGLFAEANAVACTLDMVMAGTE 299
            ++   +   +  + P  P   ++   + +   + +DP   F     +  T +++  GT+
Sbjct: 243 DLIAHSVHDHQASLDPRSP-RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTK 301

Query: 300 TTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFIT 359
           T S TL  A L + ++P VQ RVQEE+D V+G  R P L+D+ A+PYT AV+HEVQRF  
Sbjct: 302 TVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFAD 361

Query: 360 LLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFV 418
           ++P ++P     DT   GFL+PKGT VI LL +V  D +Q+ TP +FNP HFLDAN  F 
Sbjct: 362 IIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFK 421

Query: 419 KREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFTM 477
           K  AF+PFSAGRR+C+GE LAR ELFL    +LQ + L P    +P  +D TP +     
Sbjct: 422 KSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG--APEDIDLTPLSSGLGN 479

Query: 478 RPRAQALCAVPR 489
            PR   LC  PR
Sbjct: 480 LPRPFQLCLRPR 491


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  330 bits (846), Expect = 2e-90
 Identities = 183/492 (37%), Positives = 285/492 (57%), Gaps = 16/492 (3%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           +L L F+ L  LW   C          + PPGP PLP++GN+  + +    +S    S+ 
Sbjct: 8   VLCLSFMLLFSLWRQSCR-------RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFTV+ G    VV  G+EAVKEAL   G+E + R    I Q I +G GI  S+G RW
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F++  L + G+G+  + D++ +E  CL  +L   +  P  P  +LG AP N+  +
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWL-GALLQLHRPVLRKIEEV 240
           ++F +RFDY+D  F++L+   +E   +L SP +Q+ N +P L       H  VL+ +   
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 241 RAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMAGT 298
           R+ +R  ++  +  +   +P   ++D  +   + + D+ +  F   N V    D+ +AGT
Sbjct: 241 RSYIREKVKEHQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299

Query: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358
           ETTS TL++  LL+ +HP+V  +VQEE+D V+G  R+P ++D+  +PYT AV+HE+QR+ 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359

Query: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417
            L+P  VP     DT+   +L+PKGT ++ LLTSVL D+ ++  P  F+PGHFLD NG+F
Sbjct: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419

Query: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476
            K + F+PFSAG+R+C GE LAR ELFL    +LQ + L     +   +L+TT   +   
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLK--NLNTTAVTKGIV 477

Query: 477 MRPRAQALCAVP 488
             P +  +C +P
Sbjct: 478 SLPPSYQICFIP 489


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  330 bits (845), Expect = 2e-90
 Identities = 180/492 (36%), Positives = 289/492 (58%), Gaps = 16/492 (3%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           +L L  L LL +W       +  S   + PPGP PLP++GN+  + +    +SL  LS+ 
Sbjct: 8   VLCLSCLLLLSIW-------RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFT++ G ++ VVL G+E VKEAL   G+E + R    + +   RG GI FS+G RW
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F++  L + G+G+  + D++ +E +CL  +L   +  P  P  +LG AP N+  +
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPW-LGALLQLHRPVLRKIEEV 240
           ++F +RFDY+D  F++L+  ++E + ++ +P +Q+ N +P  +      H  +L+ +  +
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 241 RAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMAGT 298
            + +   ++  +  +   +P   ++D  +   + +  + +  F   N V    D++ AGT
Sbjct: 241 ESDILEKVKEHQESMDINNP-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299

Query: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358
           ETTS TL++A LL+ +HP+V  +VQEE++RV+G  R+P ++D+  +PYT AV+HEVQR+I
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417
            L+P  +P     D +   +L+PKGT ++  LTSVL D  ++  P  F+P HFLD  G+F
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419

Query: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476
            K   F+PFSAG+R+CVGE LAR ELFL    +LQ + L     + P  LDTTP    F 
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL--KSLIDPKDLDTTPVVNGFA 477

Query: 477 MRPRAQALCAVP 488
             P    LC +P
Sbjct: 478 SVPPFYQLCFIP 489


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  330 bits (845), Expect = 2e-90
 Identities = 179/464 (38%), Positives = 275/464 (59%), Gaps = 10/464 (2%)

Query: 31  WPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90
           +PPGP  LP +GN  L+   Q    +    ++YG +F++ LG    V++TG   +KEAL 
Sbjct: 43  YPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102

Query: 91  GPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQE 150
              Q   +RP   + + I +  G+  SSG  W+  R+FT+ AL + G+G++ + ++I +E
Sbjct: 103 HMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEE 162

Query: 151 LKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLL 209
            + L+  +    G+PF P   +  A SNI  ++ FG RF+Y+D  F  LL L+DEV  L 
Sbjct: 163 AQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLE 222

Query: 210 GSPGLQLFNVYPWLGALLQ-LHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDAL 268
            S   QL+NV+PW+   L   H+ +    ++++  +  +++  R    P +    ++DA 
Sbjct: 223 ASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAE-TRDFIDAY 281

Query: 269 IQQ--GQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEEL 326
           +++      +P   F E N +  TLD+  AGTETTS TL+WA L M  +P++Q +VQ E+
Sbjct: 282 LKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEI 341

Query: 327 DRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPV 385
           DRV+G G+ P    ++++PYT+AV+HEVQR   ++P +VPR    DT L G+ LPKGT +
Sbjct: 342 DRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMI 401

Query: 386 IPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFL 445
           +  LT++  D T+W TP  FNP HFL+ NG F KREAF+PFS G+R C+GE+LARTELF+
Sbjct: 402 LTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFI 460

Query: 446 LFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489
            F  L+Q++   PP   +   L        T+ P +  LCAVP+
Sbjct: 461 FFTSLMQKFTFRPP---NNEKLSLKFRMGITISPVSHRLCAVPQ 501


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  328 bits (842), Expect = 5e-90
 Identities = 189/494 (38%), Positives = 289/494 (58%), Gaps = 20/494 (4%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           +L L  L LL LW       +  S   R P GP PLP++GN+  L +    +SL   S+ 
Sbjct: 8   VLCLSCLFLLSLW-------RQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFTV+ G +  VVL G+EAVKEAL   G+E + R    + + + +G GI FS+G RW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F +  L + G+G+  + D++ +E +CL  +L      P  P  +LG AP N+  +
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241
           ++F  RFDY+D  F++L+   +E + +L SP +Q+ N +P   AL+        KI E  
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFP---ALIDYLPGSHNKIAENF 237

Query: 242 AILRT-LLEARRPHVCPGD--PVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMA 296
           A +++ +LE  + H    D      ++D  +   + +  + +  F   + +A   DM  A
Sbjct: 238 AYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGA 297

Query: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356
           GTETTS TL++  LL+ ++P+V  +VQEE++ V+G  R+P ++D+  +PYT AV+HE+QR
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQR 357

Query: 357 FITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANG 415
           +I LLP ++P     D +   +L+PKGT +I  LTSVL ++ ++  P  F+PGHFLD +G
Sbjct: 358 YIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSG 417

Query: 416 HFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARA 474
           +F K + F+PFSAG+R+C+GE LAR ELFL    +LQ + L     V P  +D TP A A
Sbjct: 418 NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL--KSQVDPKDIDITPIANA 475

Query: 475 FTMRPRAQALCAVP 488
           F   P    LC +P
Sbjct: 476 FGRVPPLYQLCFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  328 bits (841), Expect = 7e-90
 Identities = 182/492 (36%), Positives = 290/492 (58%), Gaps = 16/492 (3%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           +L L  L LL LW       +  S   + PPGP PLP++GN+  + +    +SL  LS+ 
Sbjct: 8   VLCLSCLLLLSLW-------RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFT++ G +  VVL G+EAVKEAL   G+E + R    + +   RG GI FS+G +W
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F++  L + G+G+  + D++ +E +CL  +L   +  P  P  +LG AP N+  +
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVY-PWLGALLQLHRPVLRKIEEV 240
           ++F +RFDY+D  F++L+  ++E + +L SP +Q+ N + P +      H  +L+ +  +
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 241 RAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGD--DPEGLFAEANAVACTLDMVMAGT 298
           ++ +   ++  +  +   +P   ++D  + + + +  +    F   +     +D+  AGT
Sbjct: 241 KSYILEKVKEHQESMDMNNPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299

Query: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358
           ETTS TL++A LL+ +HP+V  +VQEE++RV+G  R+P ++D+  +PYT AV+HEVQR+I
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359

Query: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417
            LLP  +P     D +   +L+PKGT ++  LTSVL D  ++  P  F+P HFLD  G+F
Sbjct: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419

Query: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476
            K + F+PFSAG+R+CVGE LA  ELFL    +LQ + L     V P +LDTTP    F 
Sbjct: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL--KSLVDPKNLDTTPVVNGFA 477

Query: 477 MRPRAQALCAVP 488
             P    LC +P
Sbjct: 478 SVPPFYQLCFIP 489


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  327 bits (839), Expect = 1e-89
 Identities = 200/470 (42%), Positives = 262/470 (55%), Gaps = 10/470 (2%)

Query: 28  AARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKE 87
           AAR+PPGP PLP +GNL  +          +L  R+G VF++ L     VVL G  AV+E
Sbjct: 30  AARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVRE 89

Query: 88  ALAGPGQELADRPPIAIFQLI---QRGGGIFFSS-GARWRAARQFTVRALHSLGVGREPV 143
           AL   G++ ADRPP+ I Q++    R  G+F +  G  WR  R+F+V  L +LG+G++ +
Sbjct: 90  ALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSL 149

Query: 144 ADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLI 202
              + +E  CL      + GRPF P  LL  A SN+  +L  GRRF+Y DP F+ LL L 
Sbjct: 150 EQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLA 209

Query: 203 DEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVC 262
            E +        ++ N  P L  +  L   VLR  +     L  LL   R    P  P  
Sbjct: 210 QEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPR 269

Query: 263 SYVDALIQQGQG--DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQG 320
              +A + + +    +PE  F + N      D+  AG  TTS TL W  LLM  HPDVQ 
Sbjct: 270 DLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR 329

Query: 321 RVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLL 379
           RVQ+E+D V+G  R P + DQ  +PYT+AV+HEVQRF  ++P  V   T+ D ++ GF +
Sbjct: 330 RVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRI 389

Query: 380 PKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLA 439
           PKGT +I  L+SVL DE  W+ P +F+P HFLDA GHFVK EAFLPFSAGRR C+GE LA
Sbjct: 390 PKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 449

Query: 440 RTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489
           R ELFL F  LLQ +    P G    S       AF + P    LCAVPR
Sbjct: 450 RMELFLFFTSLLQHFSFSVPTGQPRPS--HHGVFAFLVTPSPYELCAVPR 497


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  326 bits (836), Expect = 3e-89
 Identities = 185/466 (39%), Positives = 273/466 (58%), Gaps = 14/466 (3%)

Query: 32  PPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAG 91
           PPGP PLP++GNL  L L    +S   L++R+GPVFT+++G Q+ VV+ G++AVKEAL  
Sbjct: 33  PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92

Query: 92  PGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQEL 151
              E + R  +  F    R  GI F++G  W+  R+F++  L + G+G++    +I +E 
Sbjct: 93  YKDEFSGRGDLPAFHA-HRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 151

Query: 152 KCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLG 210
             L   L   +G+PF P  L+G AP N+   +LF + FDY D  F+ L+ L +E   LL 
Sbjct: 152 HFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLS 211

Query: 211 SPGLQLFNVYP-WLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVC--SYVDA 267
           +P LQL+N +P +L  L   HR V++ + EV+  +    E  + H    DP C     D 
Sbjct: 212 TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS---ERVKEHHQSLDPNCPRDLTDC 268

Query: 268 LIQQGQGD--DPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEE 325
           L+ + + +    E L+          D+  AGTETTS TL++  L++ ++P+++ ++ EE
Sbjct: 269 LLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEE 328

Query: 326 LDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTP 384
           +DRV+GP R P ++D+Q +PY  AV+HE+QRFITL+P ++P     DT   G+L+PKGT 
Sbjct: 329 IDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTV 388

Query: 385 VIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELF 444
           V+P L SVL D  ++  P +F P HFL+ NG F   + F PFS G+RVC GE LAR ELF
Sbjct: 389 VVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELF 448

Query: 445 LLFAGLLQRYRLLPPPGVSPASLDTTPAR-AFTMRPRAQALCAVPR 489
           LL   +LQ + L   P V P  +D +P    F   P    LC +PR
Sbjct: 449 LLLCAILQHFNL--KPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  324 bits (830), Expect = 1e-88
 Identities = 198/488 (40%), Positives = 273/488 (55%), Gaps = 17/488 (3%)

Query: 1   MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELS 60
           +ALLLLL L L G                  PPGP PLPL+GNL  LR       LM LS
Sbjct: 13  LALLLLLTLALSGT-----------RARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61

Query: 61  ERYGPVFTVHLGRQK-TVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSG 119
           ++YGPVFT++LG  +  VVL G EAV+EAL G  +E + R  +A+ +    G G+FFS+G
Sbjct: 62  KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNG 121

Query: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNI 178
            RWR  R+FT+ AL  LG+G+    + I  E +CL     G  GRPF P  LL  A SN+
Sbjct: 122 ERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNV 181

Query: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPW-LGALLQLHRPVLRKI 237
             +LLFG RF Y D  F +++      ++ + S G Q + ++ W L  L   H+ +L  +
Sbjct: 182 VCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHV 241

Query: 238 EEVRAILRTLLEARRPHVCPGDPVCSYVDA-LIQQGQGDDPEGL-FAEANAVACTLDMVM 295
             + A     ++  + ++    P    VDA L++  Q +   G  F   N +   + ++ 
Sbjct: 242 STLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLF 301

Query: 296 AGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQ 355
           AGT T S T+ +  LL+ ++P VQ  V+EEL+R LG G+ P L D+  LPYT AVLHE Q
Sbjct: 302 AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQ 361

Query: 356 RFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDAN 414
           R + L+P  +PR     T+  G+ LP+GT V PLL S+L D   ++ P +FNP  FLDA+
Sbjct: 362 RLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDAD 421

Query: 415 GHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARA 474
           G F K EAFLPFS G+RVC+GE LA+ ELFL F  +LQ + L  P      SL  T +  
Sbjct: 422 GRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGL 481

Query: 475 FTMRPRAQ 482
           F + P  Q
Sbjct: 482 FNIPPAFQ 489


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  318 bits (814), Expect = 9e-87
 Identities = 186/478 (38%), Positives = 275/478 (57%), Gaps = 13/478 (2%)

Query: 1   MALLLLLFLGLL-GLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMEL 59
           M L +LLFL LL GL  LL    + P+   R PPGPRPLPL+GNL  +      +S +  
Sbjct: 1   MELSVLLFLALLTGL--LLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRF 58

Query: 60  SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSG 119
            E+YG VFTVHLG +  V+L G EA++EAL    +  + R  IA+     RG G+ F++G
Sbjct: 59  REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANG 118

Query: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNI 178
            RW+  R+F+V  +   G+G+  V ++I +E +CL  +L   +G    P  L     +NI
Sbjct: 119 NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANI 178

Query: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYP-WLGALLQLHRPVLRKI 237
             +++FG+RF Y+D  F+ +L L  +   L+ S   QLF ++  +L      HR V + +
Sbjct: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238

Query: 238 EEVRAILRTLLEARRPHVCPGDP---VCSYVDALIQQGQGDDPEGLFAEANAVACTLDMV 294
           +E+ A +   +E  R  + P  P   + +Y+  L  + +  +    F+  N    TL + 
Sbjct: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYL--LHMEKEKSNAHSEFSHQNLNLNTLSLF 296

Query: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354
            AGTETTS TL++  LLM ++P V  RV  E+++V+GP R P L D+  +PYT AV++E+
Sbjct: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356

Query: 355 QRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413
           QRF  LLP  VP      T   G+++PK T V  +L++ L D   ++ P  FNP HFLDA
Sbjct: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416

Query: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP 471
           NG   K EAF+PFS G+R+C+GE +AR ELFL F  +LQ + +  P  V+P  +D TP
Sbjct: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP--VAPEDIDLTP 472


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  315 bits (807), Expect = 6e-86
 Identities = 189/495 (38%), Positives = 273/495 (55%), Gaps = 14/495 (2%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L   Q   SLM++SER
Sbjct: 6   LLLVTLLACLTVMVLMSVWRQRKS-RGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFT+HLG ++ VVL G +AVKEAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 65  YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERA 124

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F++  L   GVG+  + ++I +E   L   L G  G    P   L    SN+  +
Sbjct: 125 KQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISS 184

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241
           ++FG RFDY D  F+SLL ++        +   QL+ ++     +  L  P  +  +E++
Sbjct: 185 IVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQ 242

Query: 242 AI---LRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMA 296
            +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N V  TL++  A
Sbjct: 243 GLEDFIAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFA 301

Query: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356
           GTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PYT AV+HE+QR
Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361

Query: 357 FITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANG 415
           F  +LP  +      DT+   F LPKGT V P+L SVL D   +  P  FNP HFLD  G
Sbjct: 362 FGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKG 421

Query: 416 HFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR-A 474
            F K +AF+PFS G+R C GE LAR ELFL F  ++Q +R   P   SP  +D +P    
Sbjct: 422 QFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQ--SPKDIDVSPKHVG 479

Query: 475 FTMRPRAQALCAVPR 489
           F   PR   +  +PR
Sbjct: 480 FATIPRNYTMSFLPR 494


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  311 bits (797), Expect = 9e-85
 Identities = 191/498 (38%), Positives = 283/498 (56%), Gaps = 23/498 (4%)

Query: 2   ALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQ--DRSLMEL 59
           AL LLLF   LG+  LL    +   P   +PPGP  LP +GN++ L  S +     + + 
Sbjct: 17  ALFLLLFA--LGVRQLL----KQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQ 69

Query: 60  SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSS- 118
           S+ YG +F++ LG   TVVL G++ VKE L    +  ADRP + +F  + + GG+  S  
Sbjct: 70  SQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 129

Query: 119 GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLA-LLGWAPSN 177
           G  W   R+  V +    G G++    KIL+E K  +  ++ Y+GRPF    L+  A SN
Sbjct: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189

Query: 178 ITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGAL-LQLHRPVLRK 236
           IT  ++FG RF Y D  F  ++ L  E + L  S  + L+N +PW+G L    H+ + R 
Sbjct: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249

Query: 237 IEEVRAILRTLLEA----RRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLD 292
              V   L  L+E     R+P + P   V +Y+D +  QG+ +DP   F++ N +    +
Sbjct: 250 AAVVYDFLSRLIEKASVNRKPQL-PQHFVDAYLDEM-DQGK-NDPSSTFSKENLIFSVGE 306

Query: 293 MVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLH 352
           +++AGTETT+  L+WA L M  +P++QG+VQ+E+D ++GP   P  +D+  +PYT AVLH
Sbjct: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366

Query: 353 EVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL 411
           EV RF  ++P  +   T+ D  + G+ +PKGT VI  L SV  DE  W+ P  F+P  FL
Sbjct: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426

Query: 412 DANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP 471
           D++G+F K+EA +PFS GRR C+GE LAR E+FL F  LLQR+ L  P  + P   D  P
Sbjct: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP---DLKP 483

Query: 472 ARAFTMRPRAQALCAVPR 489
               T++P+   +CA  R
Sbjct: 484 RLGMTLQPQPYLICAERR 501


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  308 bits (788), Expect = 9e-84
 Identities = 181/497 (36%), Positives = 273/497 (54%), Gaps = 24/497 (4%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           L+ L  + L+ +W       Q      + PPGP PLP +GN   L   Q   SLM++SER
Sbjct: 12  LVCLTVMVLMSVW-------QQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFT+HLG ++ VVL G +AV+EAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERA 124

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F++  L   GVG+  + ++I +E   L   L G  G    P   L    SN+  +
Sbjct: 125 KQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISS 184

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236
           ++FG RFDY+D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 185 IVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFQL 240

Query: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N V  TL++ 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 299

Query: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354
           + GTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEI 359

Query: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFL+ 
Sbjct: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419

Query: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 420 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 477

Query: 474 -AFTMRPRAQALCAVPR 489
             F   PR   +  +PR
Sbjct: 478 VGFATIPRNYTMSFLPR 494


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  305 bits (781), Expect = 6e-83
 Identities = 179/489 (36%), Positives = 264/489 (53%), Gaps = 69/489 (14%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           +L L  L LL LW       +  S   R P GP PLP++GN+  L +    +SL   S+ 
Sbjct: 8   VLCLSCLFLLSLW-------RQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFTV+ G +  VVL G+EAVKEAL   G+E + R    + + + +G GI FS+G RW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +  R+F +  L + G+G+  + D++ +E +CL  +L      P  P  +LG AP N+  +
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241
           ++F  RFDY+D  F++L+   +E + +L S         PW                   
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSS---------PW------------------- 212

Query: 242 AILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETT 301
                                      IQ+      E  F   + +A   DM  AGTETT
Sbjct: 213 ---------------------------IQEKHNQQSE--FTVESLIATVTDMFGAGTETT 243

Query: 302 SATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLL 361
           S TL++  LL+ ++P+V  +VQEE++ V+G  R+P ++D+  +PYT AV+HE+QR+I LL
Sbjct: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303

Query: 362 P-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR 420
           P ++P     D +   +L+PKGT +I  LTSVL ++ ++  P  F+PGHFLD +G+F K 
Sbjct: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363

Query: 421 EAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFTMRP 479
           + F+PFSAG+R+C+GE LAR ELFL    +LQ + L     V P  +D TP A AF   P
Sbjct: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL--KSQVDPKDIDITPIANAFGRVP 421

Query: 480 RAQALCAVP 488
               LC +P
Sbjct: 422 PLYQLCFIP 430


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  297 bits (760), Expect = 2e-80
 Identities = 179/497 (36%), Positives = 269/497 (54%), Gaps = 18/497 (3%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L       S+M+ SE 
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKS-RGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSEC 64

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
           YGPVFT+HLG ++ VVL G +AV+EAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERA 124

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +   +F +  L   GVG+  + ++I +E   L   +    G    P   L    SN+  +
Sbjct: 125 KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISS 184

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236
           ++FG RFDY D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 185 IVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFKL 240

Query: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N +  TL++ 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLF 299

Query: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354
           +AGTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 359

Query: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFLD 
Sbjct: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 419

Query: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 420 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 477

Query: 474 -AFTMRPRAQALCAVPR 489
             F   PR   +  +PR
Sbjct: 478 VVFATIPRNYTMSFLPR 494


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  281 bits (718), Expect = 1e-75
 Identities = 187/466 (40%), Positives = 237/466 (50%), Gaps = 53/466 (11%)

Query: 28  AARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKE 87
           AAR+PPGP PLP +GNL  +          +L  R+G VF++ L     VVL G  AV+E
Sbjct: 30  AARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVRE 89

Query: 88  ALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKI 147
           AL   G++ ADRPP+ I Q+                            LG G        
Sbjct: 90  ALVTHGEDTADRPPVPITQI----------------------------LGFGPRS----- 116

Query: 148 LQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVM 206
                         +GRPF P  LL  A SN+  +L  GRRF+Y DP F+ LL L  E +
Sbjct: 117 --------------QGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGL 162

Query: 207 VLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVD 266
                   ++ N  P L  +  L   VLR  +     L  LL   R    P  P     +
Sbjct: 163 KEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTE 222

Query: 267 ALIQQGQG--DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQE 324
           A + + +    +PE  F + N      D+  AG  TTS TL W  LLM  HPDVQ RVQ+
Sbjct: 223 AFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 282

Query: 325 ELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGT 383
           E+D V+G  R P + DQ  +PYT+AV+HEVQRF  ++P  V   T+ D ++ GF +PKGT
Sbjct: 283 EIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGT 342

Query: 384 PVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTEL 443
            +I  L+SVL DE  W+ P +F+P HFLDA GHFVK EAFLPFSAGRR C+GE LAR EL
Sbjct: 343 TLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMEL 402

Query: 444 FLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489
           FL F  LLQ +    P G    S       AF + P    LCAVPR
Sbjct: 403 FLFFTSLLQHFSFSVPTGQPRPS--HHGVFAFLVTPSPYELCAVPR 446


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  260 bits (665), Expect = 2e-69
 Identities = 164/488 (33%), Positives = 260/488 (53%), Gaps = 37/488 (7%)

Query: 2   ALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNL-HLLR---------LSQ 51
           ALLL   + LLG W  L         A   PPGP P PLVGN  H+L          LS 
Sbjct: 36  ALLLCGLVALLG-WSWLRR-----RRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSS 89

Query: 52  QDRS-------------LMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELAD 98
           + R+             L  L+  YG +F+  +G    VVL+ F +V+EAL    +  +D
Sbjct: 90  RTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSD 149

Query: 99  RPPIAIFQLIQRGGGIFFSS-GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQ 157
           RP + +  ++ +  G+ F+  G  WR  R+F+   L   G+G+  +  KI++E K +  +
Sbjct: 150 RPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAE 209

Query: 158 LDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL 216
           +  +   PF P +++  A SNI  +L FG+RFDY +  F  +LG +   + +  +  + L
Sbjct: 210 MQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLL 269

Query: 217 FNVYPWLGALLQLHRPVLRKIE-EVRAILRTLLEARRPHVCPGDPVCSYVDALI---QQG 272
            N+ PWL  L       LR+IE ++ + L+ +++  +  +   +P   ++D  +   ++ 
Sbjct: 270 VNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQ-DFIDMYLLHMEEE 328

Query: 273 QGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP 332
           + ++    F E        D+ +AGT+TT+ +L W  L M  +PDVQ +V EE++RV+G 
Sbjct: 329 RKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA 388

Query: 333 GRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTS 391
            R P L D+  +PYT A + EVQR   ++P  +P  T+ +T L G+ +PKGT ++P L S
Sbjct: 389 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWS 448

Query: 392 VLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLL 451
           V  D   W+ P  F P  FLD  G  +K+E F+PF  G+RVC+GE+LA+ ELFL+F  L+
Sbjct: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508

Query: 452 QRYRLLPP 459
           Q +    P
Sbjct: 509 QSFAFALP 516


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  229 bits (585), Expect = 3e-60
 Identities = 155/497 (31%), Positives = 238/497 (47%), Gaps = 69/497 (13%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L       S+M++S+ 
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKS-RGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ- 63

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122
                                                             G+ FS+G R 
Sbjct: 64  --------------------------------------------------GVAFSNGERA 73

Query: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181
           +   +F +  L   GVG+  + ++I +E   L   +    G    P   L    SN+  +
Sbjct: 74  KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISS 133

Query: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236
           ++FG RFDY D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 134 IVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFKL 189

Query: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N +  TL++ 
Sbjct: 190 LQGLEDFIAKKVEHNQRTLDPNSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLF 248

Query: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354
           +AGTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 249 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 308

Query: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFLD 
Sbjct: 309 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 368

Query: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 369 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 426

Query: 474 -AFTMRPRAQALCAVPR 489
             F   PR   +  +PR
Sbjct: 427 VVFATIPRNYTMSFLPR 443


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  202 bits (514), Expect = 6e-52
 Identities = 158/478 (33%), Positives = 231/478 (48%), Gaps = 41/478 (8%)

Query: 32  PPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAG 91
           PPGP   PL+GN   +  +    S   L+ RYG VF + LG    VVL G  A+ +AL  
Sbjct: 51  PPGPFAWPLIGNAAAVGQAAH-LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109

Query: 92  PGQELADRPPIAIFQLIQRGGGIFFSS-GARWRAARQFTVRALHSLGVG---REPVADKI 147
            G   ADRP  A F+++  G  + F      W+  R    RA HS+      R+P + ++
Sbjct: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQR----RAAHSMMRNFFTRQPRSRQV 165

Query: 148 LQ--------ELKCL--SGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVS 197
           L+        EL  L   G  DG    P PL ++  A +N+  A+ FG R+ + DP F  
Sbjct: 166 LEGHVLSEARELVALLVRGSADGAFLDPRPLTVV--AVANVMSAVCFGCRYSHDDPEFRE 223

Query: 198 LLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLL--------E 249
           LL   +E    +G+  L   +V PWL       R V R+ E++       +        E
Sbjct: 224 LLSHNEEFGRTVGAGSL--VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCE 281

Query: 250 ARRPHVCPGDPVCSYVDALIQQGQGDDPEG---LFAEANAVACTLDMVMAGTETTSATLQ 306
           + RP   P D + +++ +  ++  GD   G   L  E N  A   D+  A  +T S  LQ
Sbjct: 282 SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE-NVPATITDIFGASQDTLSTALQ 340

Query: 307 WAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVP 365
           W  LL  R+PDVQ RVQ ELD+V+G  R P + DQ  LPY  A L+E  RF + +P  +P
Sbjct: 341 WLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIP 400

Query: 366 RCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVK--REAF 423
             T A+T + G+ +PK T V     SV  D  +W  P  F+P  FLD +G   K      
Sbjct: 401 HATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRV 460

Query: 424 LPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRA 481
           + FS G+R C+GE L++ +LFL  + L  +      P   PA ++   +   T++P++
Sbjct: 461 MIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN-EPAKMNF--SYGLTIKPKS 515


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  195 bits (496), Expect = 7e-50
 Identities = 147/498 (29%), Positives = 234/498 (46%), Gaps = 34/498 (6%)

Query: 4   LLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDR-SLMELSER 62
           LL   +  L  W +  +  Q P    + PPGP   PL+G  H+L L +    +L  +S++
Sbjct: 13  LLASVIFCLVFWVIRASRPQVPK-GLKNPPGPWGWPLIG--HMLTLGKNPHLALSRMSQQ 69

Query: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFS--SGA 120
           YG V  + +G    VVL+G + +++AL   G +   RP +  F LI  G  + FS  SG 
Sbjct: 70  YGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGP 129

Query: 121 RWRAARQFTVRALHSLGVGREPVA-------DKILQELKCLSGQLDGYRGRPF---PLAL 170
            W A R+     L S  +  +P +       + + +E + L   L      P    P   
Sbjct: 130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRY 189

Query: 171 LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLH 230
           +  + +N+  A+ FGRR+D+     +SL+ L +    ++GS      N   ++  L  L 
Sbjct: 190 VVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG-----NPADFIPILRYLP 244

Query: 231 RPVLRKIEEVRAILRTLLEAR-RPHVCPGDP--VCSYVDALI---QQGQGDDPEGL-FAE 283
            P L   +++     + ++   + H    +   +    D+LI   Q+ Q D+   +  ++
Sbjct: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304

Query: 284 ANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQA 343
              +   LD+  AG +T +  + W+ + +  +P VQ ++QEELD V+G  R PRL D+  
Sbjct: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364

Query: 344 LPYTSAVLHEVQRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTP 402
           LPY  A + E  R  + +P  +P  T  DT L GF +PKG  V      +  D+  W  P
Sbjct: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424

Query: 403 GQFNPGHFLDANGHF--VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPP 460
            +F P  FL  +G    V  E  + F  G+R C+GE +AR E+FL  A LLQR     P 
Sbjct: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPL 484

Query: 461 GVSPASLDTTPARAFTMR 478
           GV    +D TP    TM+
Sbjct: 485 GV---KVDMTPIYGLTMK 499


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  180 bits (457), Expect = 2e-45
 Identities = 138/488 (28%), Positives = 225/488 (46%), Gaps = 22/488 (4%)

Query: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLL-RLSQQDRSLMELSE 61
           L+ LL L L  L+     C     P A++P     LPLVG+L  L R      +  +L +
Sbjct: 4   LVALLLLTLAYLFWPKRRC-----PGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58

Query: 62  RYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQ--RGGGIFFSSG 119
           +YGP+++V +G + TV++   +  KE L   G++ + RP +A   +    R G  F  SG
Sbjct: 59  KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118

Query: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGW-APSNI 178
           A W+  R+  +        G + +   I QE+  L   L  + G+   ++   + A +N+
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178

Query: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIE 238
              + F   +   DP    +    + ++  L    L   ++ PWL          L+   
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSL--VDLVPWLKIFPNKTLEKLKSHV 236

Query: 239 EVRAILRTLLEARRPHVCPGDPVCSYVDALIQQ-------GQGDDPEGLFAEANAVACTL 291
           ++R  L   +          D + + +D L+Q          G D +      N +  T+
Sbjct: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296

Query: 292 -DMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAV 350
            D+  AG ETT++ ++W    +  +P V+ ++ EE+D+ +G  RTP + D+  L    A 
Sbjct: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356

Query: 351 LHEVQRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGH 409
           + EV R   + P  +P     D+ +G F + KGT VI  L ++  +E +W  P QF P  
Sbjct: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416

Query: 410 FLDANGHFV--KREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASL 467
           FL+  G  +     ++LPF AG R C+GE LAR ELFL+ A LLQR+ L  P      SL
Sbjct: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476

Query: 468 DTTPARAF 475
           +  P   F
Sbjct: 477 EGIPKVVF 484


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  175 bits (444), Expect = 7e-44
 Identities = 138/469 (29%), Positives = 215/469 (45%), Gaps = 32/469 (6%)

Query: 32  PPGPRPLPLVGNLHLLRLSQQDR-SLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90
           PP P   PL+G  H+L L +    +L  +S+RYG V  + +G    +VL+  + +++AL 
Sbjct: 42  PPEPWGWPLLG--HVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALV 99

Query: 91  GPGQELADRPPIAIFQLIQRGGGIFFS--SGARWRAARQFTVRALHSLGVGREPVA---- 144
             G +   RP +    LI  G  + FS  SG  W A R+    AL++  +  +P +    
Sbjct: 100 RQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSC 159

Query: 145 ---DKILQELKCLSGQLDGYRGRPF---PLALLGWAPSNITFALLFGRRFDYRDPVFVSL 198
              + + +E K L  +L      P    P   +  + +N+  A+ FG+ F       +SL
Sbjct: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSL 219

Query: 199 LGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEV-RAILRTLLEARRPHVCP 257
           +    E +    S      N   +   L  L  P L++ +   +  L  L +  + H   
Sbjct: 220 VKNTHEFVETASSG-----NPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD 274

Query: 258 GDP--VCSYVDALIQQGQ-GDDPEG-LFAEANAVACTLDMVMAGTETTSATLQWAALLMG 313
            D   V     AL +  + G    G L  +   V    D+  AG +T +  + W+ + + 
Sbjct: 275 FDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334

Query: 314 RHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPH-VPRCTAADT 372
             P++Q ++Q+ELD V+G  R PRL D+  LPY  A + E  R  + LP  +P  T  DT
Sbjct: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394

Query: 373 QLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR---EAFLPFSAG 429
            L GF +PK   V      V  D   W+ P +F P  FL A+G  + +   E  + F  G
Sbjct: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454

Query: 430 RRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMR 478
           +R C+GE LA+ E+FL  A LLQ+     PPGV    +D TP    TM+
Sbjct: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIYGLTMK 500


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  172 bits (437), Expect = 5e-43
 Identities = 137/443 (30%), Positives = 215/443 (48%), Gaps = 36/443 (8%)

Query: 42  GNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPP 101
           G LHLL+       L+ L++++GP++ +HLG Q  VVL     ++EA+     + A RP 
Sbjct: 36  GFLHLLQ-PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE 94

Query: 102 IAIFQLIQRGGGIFFSS--GARWRAARQFTVRALHSLGV--GREPVADKILQELKCLSGQ 157
              ++L+ R             W+A ++ T  AL  LG+    EPV +++ QE       
Sbjct: 95  PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSAL-LLGIRDSMEPVVEQLTQEF------ 147

Query: 158 LDGYRGRP-FPLAL---LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPG 213
            +  R +P  P+A+         +I   L FG +    D +  +    I EV+       
Sbjct: 148 CERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWS 206

Query: 214 LQLFNVYPWLGALLQLHRPVLRK----IEEVRAILRTLLEARRPHVCPGD--PVCSYVDA 267
           +Q+ +V P+L        P LR+    IE+   I+   L   +  +  G    +  Y+  
Sbjct: 207 IQIVDVIPFLRFF---PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ 263

Query: 268 LIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELD 327
            + Q   ++  G   E +     +D+++ GTETT+ TL WA + +  HP++Q R+QEELD
Sbjct: 264 GVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELD 323

Query: 328 RVLGPG----RTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKG 382
             LGPG    R P  +D+  LP  +A + EV R   ++P  +P  T   + + G+ +P+G
Sbjct: 324 HELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382

Query: 383 TPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTE 442
           T +IP L    LDET W+ P +F P  FL+      K    L F  G RVC+GE LAR E
Sbjct: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438

Query: 443 LFLLFAGLLQRYRLLPPPGVSPA 465
           LF++   LLQ + LLP     P+
Sbjct: 439 LFVVLTRLLQAFTLLPSGDALPS 461


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  153 bits (386), Expect = 4e-37
 Identities = 132/441 (29%), Positives = 207/441 (46%), Gaps = 62/441 (14%)

Query: 42  GNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPP 101
           G LHLL+       L+ L++++GP++ +HLG Q  +V   +         P   L D   
Sbjct: 36  GFLHLLQ-PDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNY---------PDLSLGD--- 82

Query: 102 IAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGV--GREPVADKILQELKCLSGQLD 159
              + L+             W+A ++ T  AL  LG+    EPV +++ QE        +
Sbjct: 83  ---YSLL-------------WKAHKKLTRSAL-LLGIRDSMEPVVEQLTQEF------CE 119

Query: 160 GYRGRP-FPLAL---LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQ 215
             R +P  P+A+         +I   L FG +    D +  +    I EV+       +Q
Sbjct: 120 RMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQ 178

Query: 216 LFNVYPWLGALLQLHRPVLRK----IEEVRAILRTLLEARRPHVCPGD--PVCSYVDALI 269
           + +V P+L        P LR+    IE+   I+   L   +  +  G    +  Y+   +
Sbjct: 179 IVDVIPFLRFF---PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGV 235

Query: 270 QQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRV 329
            Q   ++  G   E +     +D+++ GTETT+ TL WA + +  HP++Q R+QEELD  
Sbjct: 236 AQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE 295

Query: 330 LGPG----RTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTP 384
           LGPG    R P  +D+  LP  +A + EV R   ++P  +P  T   + + G+ +P+GT 
Sbjct: 296 LGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTV 354

Query: 385 VIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELF 444
           +IP L    LDET W+ P +F P  FL+      K    L F  G RVC+GE LAR ELF
Sbjct: 355 IIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELF 410

Query: 445 LLFAGLLQRYRLLPPPGVSPA 465
           ++   LLQ + LLP     P+
Sbjct: 411 VVLTRLLQAFTLLPSGDALPS 431


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  114 bits (284), Expect = 3e-25
 Identities = 118/448 (26%), Positives = 193/448 (43%), Gaps = 49/448 (10%)

Query: 33  PGPRPLPLVGNLHLLR----LSQQDRSLMELSERYGPVFTVHLGRQKTVVLTG---FEAV 85
           PGP   PL+G+L  +     L +Q  +L+E  ++YG +F + LG  ++V L      EA+
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL 118

Query: 86  KEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVAD 145
               +   Q L  +P  A     + G G+    G  W+  R    + L   G   + + +
Sbjct: 119 YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LDN 177

Query: 146 KILQELKCLSGQLDGY---RGRPFPL--ALLGWAPSNITFALLFGRRFDYRDPVFVSLLG 200
           KI + L    G++D     RG    L   L  W+  +I   +L+ +RF           G
Sbjct: 178 KINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL-VLYEKRF-----------G 225

Query: 201 LIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDP 260
           L+ +      + G +  N    +  ++     ++    E+   L T  +  + H    D 
Sbjct: 226 LLQK------NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNT--KVWQDHTLAWDT 277

Query: 261 VCSYVDALI--------QQGQGDD-----PEGLFAEANAVACTLDMVMAGTETTSATLQW 307
           +   V A I        QQ   D       +   ++    A   ++ +A  ETT+ +L W
Sbjct: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMW 337

Query: 308 AALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRC 367
               + R+P VQ ++ +E+  VL   + PR ED + +PY  A L E  R    +P   R 
Sbjct: 338 ILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397

Query: 368 TAADTQLGGFLLPKGTPVIPLLTSVL-LDETQWQTPGQFNPGHFLDANGHFVKREAFLPF 426
               T LG + LPKGT V+ L T VL   E  ++   QF P  +L      +   A LPF
Sbjct: 398 LDKATVLGEYALPKGT-VLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFAHLPF 455

Query: 427 SAGRRVCVGERLARTELFLLFAGLLQRY 454
             G+R+C+G RLA  +L L    ++++Y
Sbjct: 456 GVGKRMCIGRRLAELQLHLALCWIVRKY 483


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  105 bits (262), Expect = 9e-23
 Identities = 107/460 (23%), Positives = 194/460 (42%), Gaps = 38/460 (8%)

Query: 33  PGPRPLPLVGNL--HLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90
           PGP PLP +G +  +L  L   DR   E +E+YG ++ ++ G+Q  +V+   + +K  L 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDR---ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95

Query: 91  GPGQEL-ADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGR-----EPVA 144
                +  ++ P+     ++    + F+    W+  R     A  S+             
Sbjct: 96  KECYSVFTNQMPLGPMGFLK--SALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCG 153

Query: 145 DKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDY----RDPVFVSLLG 200
           D +++ L+  +        + F     G    ++    LFG   D     +DP   ++  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDF----FGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKK 209

Query: 201 LIDEVMVLLGSPGLQLFNVYPWLGALLQ------LHRPVLRKIEE-VRAILRTLLEARRP 253
           L+    +    P L L +++P+L  + +        + V   ++  +  +  + L+ ++ 
Sbjct: 210 LLKLDFL---DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK 266

Query: 254 HVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMG 313
           H    D     +D+  Q  +        ++   VA ++ ++ A  +TTS TL +    + 
Sbjct: 267 HRV--DFFQQMIDS--QNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELA 322

Query: 314 RHPDVQGRVQEELDRVLGPGRTPRLEDQQA-LPYTSAVLHEVQRFITLLPHVPRCTAADT 372
            HPDVQ ++QEE+D VL P + P   D    + Y   V++E  R   ++  V R    D 
Sbjct: 323 THPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDI 381

Query: 373 QLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRV 432
           ++ G  +PKG  V+  + ++  D   W  P +F P  F   N   +    ++PF AG R 
Sbjct: 382 EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRN 441

Query: 433 CVGERLARTELFLLFAGLLQRYRLLPPPGVS-PASLDTTP 471
           C+G R A T + L     LQ +   P      P  LD  P
Sbjct: 442 CIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  105 bits (261), Expect = 1e-22
 Identities = 108/456 (23%), Positives = 186/456 (40%), Gaps = 57/456 (12%)

Query: 33  PGPRPLPLVGNLHLLRLSQQDRSLM---ELSERYGPVFTVHLGRQKTVVLTGFEAVKEAL 89
           PGP PLP +GN+    LS      M   E  ++YG V+  + G+Q  + +T  + +K  L
Sbjct: 39  PGPTPLPFLGNI----LSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVL 94

Query: 90  AGPGQEL-ADRPPIAIFQLIQRGGGIFFSSGARWRAARQ-----FTVRALHSLGVGREPV 143
                 +  +R P      ++    I  +    W+  R      FT   L  +       
Sbjct: 95  VKECYSVFTNRRPFGPVGFMK--SAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQY 152

Query: 144 ADKILQELKCLSGQLDGYRGRPFPLA-LLGWAPSNITFALLFG----------------- 185
            D +++ L+      +   G+P  L  + G    ++  +  FG                 
Sbjct: 153 GDVLVRNLR-----REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENT 207

Query: 186 ---RRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRA 242
               RFD+ DP F+S+      V   L  P L++ N+  +   +    R  +++++E R 
Sbjct: 208 KKLLRFDFLDPFFLSIT-----VFPFL-IPILEVLNICVFPREVTNFLRKSVKRMKESR- 260

Query: 243 ILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTS 302
                LE  + H    D +   +D+  Q  +  +     ++   VA ++  + AG ETTS
Sbjct: 261 -----LEDTQKHRV--DFLQLMIDS--QNSKETESHKALSDLELVAQSIIFIFAGYETTS 311

Query: 303 ATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP 362
           + L +    +  HPDVQ ++QEE+D VL     P  +    + Y   V++E  R   +  
Sbjct: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371

Query: 363 HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREA 422
            + R    D ++ G  +PKG  V+    ++  D   W  P +F P  F   N   +    
Sbjct: 372 RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431

Query: 423 FLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLP 458
           + PF +G R C+G R A   + L    +LQ +   P
Sbjct: 432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  101 bits (252), Expect = 1e-21
 Identities = 107/461 (23%), Positives = 194/461 (42%), Gaps = 39/461 (8%)

Query: 33  PGPRPLPLVGNL--HLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90
           PGP PLP +G +  +L  L   DR   E +E+YG ++ ++ G+Q  +V+   + +K  L 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDR---ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95

Query: 91  GPGQEL-ADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGR-----EPVA 144
                +  ++ P+     ++    + F+    W+  R     A  S+             
Sbjct: 96  KECYSVFTNQMPLGPMGFLK--SALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCG 153

Query: 145 DKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDY----RDPVFVSLLG 200
           D +++ L+  +        + F     G    ++    LFG   D     +DP   ++  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDF----FGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKK 209

Query: 201 LIDEVMVLLGSPGLQLFNVYPWLGALLQ------LHRPVLRKIEE-VRAILRTLLEARRP 253
           L+    +    P L L +++P+L  + +        + V   ++  +  +  + L+ ++ 
Sbjct: 210 LLKLDFL---DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK 266

Query: 254 HVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMG 313
           H    D     +D+  Q  +        ++   VA ++ ++ A  +TTS TL +    + 
Sbjct: 267 HRV--DFFQQMIDS--QNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELA 322

Query: 314 RHPDVQGRVQEELDRVLGPGRTPRLEDQQA-LPYTSAVLHEVQRFITLLPHVPRCTAADT 372
            HPDVQ ++QEE+D VL P + P   D    + Y   V++E  R   ++  V R    D 
Sbjct: 323 THPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDI 381

Query: 373 QLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNP-GHFLDANGHFVKREAFLPFSAGRR 431
           ++ G  +PKG  V+  + ++  D   W  P +F P   F   N   +    ++PF AG R
Sbjct: 382 EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPR 441

Query: 432 VCVGERLARTELFLLFAGLLQRYRLLPPPGVS-PASLDTTP 471
            C+G R A T + L     LQ +   P      P  LD  P
Sbjct: 442 NCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  101 bits (251), Expect = 2e-21
 Identities = 59/175 (33%), Positives = 86/175 (49%), Gaps = 3/175 (1%)

Query: 292 DMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRT--PRLEDQQALPYTSA 349
           ++++AG +T S TL WA   + RHP+VQ  +  E+   L PG +  P       LP   A
Sbjct: 313 ELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKA 372

Query: 350 VLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGH 409
           V+ EV R   ++P   R    D  +G +++PK T V     +   D  Q+  P  F P  
Sbjct: 373 VVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPAR 432

Query: 410 FLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSP 464
           +L   G      A LPF  G+R C+G RLA  EL +  A +L  + + P PG +P
Sbjct: 433 WL-GEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAP 486


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.142    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,636,675
Number of Sequences: 37866
Number of extensions: 1073622
Number of successful extensions: 4411
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4152
Number of HSP's gapped (non-prelim): 116
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.