Guide to the Human Genome
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Search of human proteins with 63054845

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
         (427 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ...   868   0.0  
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s...   868   0.0  
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof...   300   1e-81
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof...   300   1e-81
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof...   289   3e-78
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso...   209   4e-54
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   209   4e-54
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom...   197   1e-50
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo...   170   3e-42
gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            160   2e-39
gi|189491769 thyroid hormone receptor, beta [Homo sapiens]            160   2e-39
gi|40806162 thyroid hormone receptor, beta [Homo sapiens]             160   2e-39
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi...   156   4e-38
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   156   4e-38
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     156   4e-38
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   150   3e-36
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    150   3e-36
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     150   3e-36
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi...   139   5e-33
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa...   139   5e-33
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa...   139   5e-33
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa...   139   5e-33
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa...   139   5e-33
gi|117938740 constitutive androstane receptor isoform 8 [Homo sa...   139   5e-33
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa...   139   5e-33
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa...   139   5e-33
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi...   139   5e-33
gi|50348666 peroxisome proliferative activated receptor, alpha [...   136   3e-32
gi|7549811 peroxisome proliferative activated receptor, alpha [H...   136   3e-32
gi|117938750 constitutive androstane receptor isoform 10 [Homo s...   130   2e-30

>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  868 bits (2244), Expect = 0.0
 Identities = 427/427 (100%), Positives = 427/427 (100%)

Query: 1   MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
           MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
Sbjct: 1   MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60

Query: 61  PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
           PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
Sbjct: 61  PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120

Query: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
           RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
Sbjct: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180

Query: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
           DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
Sbjct: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240

Query: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
           VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
Sbjct: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300

Query: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
           TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
Sbjct: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360

Query: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
           NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
Sbjct: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420

Query: 421 VFGNEIS 427
           VFGNEIS
Sbjct: 421 VFGNEIS 427


>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  868 bits (2244), Expect = 0.0
 Identities = 427/427 (100%), Positives = 427/427 (100%)

Query: 1   MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
           MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
Sbjct: 1   MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60

Query: 61  PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
           PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
Sbjct: 61  PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120

Query: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
           RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
Sbjct: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180

Query: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
           DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
Sbjct: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240

Query: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
           VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
Sbjct: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300

Query: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
           TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
Sbjct: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360

Query: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
           NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
Sbjct: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420

Query: 421 VFGNEIS 427
           VFGNEIS
Sbjct: 421 VFGNEIS 427


>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
           2 [Homo sapiens]
          Length = 473

 Score =  300 bits (769), Expect = 1e-81
 Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)

Query: 21  PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
           P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A   CPF  G C IT+  RR CQAC
Sbjct: 77  PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 136

Query: 80  RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
           RL++C++ GM KE I++DE V+ +R +I ++K E      L  + L+EEQ+ +I  L+DA
Sbjct: 137 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 196

Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
             KT+D T+S F  FR P  ++ G       P S   PS   + ++  S        +  
Sbjct: 197 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 250

Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
           S      D S  +   P+ +      S+LPH+AD+ +Y  + +I FAK+I  FRDL  ED
Sbjct: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310

Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
           QI LLK +A E+  LR N  F  +  +W CG   Y     + T  G    L+EP++KF  
Sbjct: 311 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 367

Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
            LKKL LHEEE+VL+ AI + SPDRPGV    +++ +Q++ + TL++YI C  P P    
Sbjct: 368 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 427

Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
           L+ K++  L +LRS+N +H++  R L  Q +     TPL+ E+FG
Sbjct: 428 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 469


>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
           1 [Homo sapiens]
          Length = 434

 Score =  300 bits (769), Expect = 1e-81
 Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)

Query: 21  PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
           P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A   CPF  G C IT+  RR CQAC
Sbjct: 38  PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97

Query: 80  RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
           RL++C++ GM KE I++DE V+ +R +I ++K E      L  + L+EEQ+ +I  L+DA
Sbjct: 98  RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157

Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
             KT+D T+S F  FR P  ++ G       P S   PS   + ++  S        +  
Sbjct: 158 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 211

Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
           S      D S  +   P+ +      S+LPH+AD+ +Y  + +I FAK+I  FRDL  ED
Sbjct: 212 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 271

Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
           QI LLK +A E+  LR N  F  +  +W CG   Y     + T  G    L+EP++KF  
Sbjct: 272 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 328

Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
            LKKL LHEEE+VL+ AI + SPDRPGV    +++ +Q++ + TL++YI C  P P    
Sbjct: 329 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 388

Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
           L+ K++  L +LRS+N +H++  R L  Q +     TPL+ E+FG
Sbjct: 389 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 430


>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
           3 [Homo sapiens]
          Length = 397

 Score =  289 bits (740), Expect = 3e-78
 Identities = 164/405 (40%), Positives = 230/405 (56%), Gaps = 51/405 (12%)

Query: 21  PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
           P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A   CPF  G C IT+  RR CQAC
Sbjct: 38  PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97

Query: 80  RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
           RL++C++ GM KE I++DE V+ +R +I ++K E      L  + L+EEQ+ +I  L+DA
Sbjct: 98  RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157

Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
             KT+D T+S F  FR  +++    GS      +   P+ SG                  
Sbjct: 158 QMKTFDTTFSHFKNFRVSLQLRGEDGS----VWNYKPPADSGGKEI-------------- 199

Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
                                     S+LPH+AD+ +Y  + +I FAK+I  FRDL  ED
Sbjct: 200 -------------------------FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 234

Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
           QI LLK +A E+  LR N  F  +  +W CG   Y     + T  G    L+EP++KF  
Sbjct: 235 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 291

Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
            LKKL LHEEE+VL+ AI + SPDRPGV    +++ +Q++ + TL++YI C  P P    
Sbjct: 292 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 351

Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
           L+ K++  L +LRS+N +H++  R L  Q +     TPL+ E+FG
Sbjct: 352 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 393


>gi|194294519 nuclear receptor subfamily 1, group H, member 3
           isoform c [Homo sapiens]
          Length = 402

 Score =  209 bits (532), Expect = 4e-54
 Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
           +C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C   G C +    RR CQ CRL+
Sbjct: 52  LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 111

Query: 83  RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
           +C   GM +E +L++E+++ K+   LKR+EEE                       AH  +
Sbjct: 112 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 146

Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
             P  S   Q  P +     G                        +  + +    +  SF
Sbjct: 147 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 184

Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
           S+          P      ++     H  +L   S+Q+++ FAK +PGF  L+ EDQI L
Sbjct: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244

Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
           LK+SAIEV++L ++  +     S T   +D+ Y   D  KAG  +E I P+ +F   + +
Sbjct: 245 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 303

Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
           L L++ E  LL+AI I S DRP VQD   +E +Q      L  Y+   H  P   L++ +
Sbjct: 304 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 361

Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           M+ KL  LR+L+  HS+Q   L  Q +   KL PL+ E++
Sbjct: 362 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 398


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  209 bits (532), Expect = 4e-54
 Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
           +C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C   G C +    RR CQ CRL+
Sbjct: 97  LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 156

Query: 83  RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
           +C   GM +E +L++E+++ K+   LKR+EEE                       AH  +
Sbjct: 157 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 191

Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
             P  S   Q  P +     G                        +  + +    +  SF
Sbjct: 192 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 229

Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
           S+          P      ++     H  +L   S+Q+++ FAK +PGF  L+ EDQI L
Sbjct: 230 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 289

Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
           LK+SAIEV++L ++  +     S T   +D+ Y   D  KAG  +E I P+ +F   + +
Sbjct: 290 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 348

Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
           L L++ E  LL+AI I S DRP VQD   +E +Q      L  Y+   H  P   L++ +
Sbjct: 349 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 406

Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           M+ KL  LR+L+  HS+Q   L  Q +   KL PL+ E++
Sbjct: 407 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 443


>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
           sapiens]
          Length = 461

 Score =  197 bits (502), Expect = 1e-50
 Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80
           +C VCGD+A+GFH+N ++CEGCKGFFRRS+ R     + C   G C++    RR CQ CR
Sbjct: 86  LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145

Query: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140
           L++C + GM ++ +L++E++++K+  I K++++E+   S  P   +              
Sbjct: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189

Query: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197
                                G  S  S P +    S +G   S   +   +T++   M+
Sbjct: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228

Query: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247
                + L  ++   SD P VT            ++     H  +L   S+Q+++ FAK 
Sbjct: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288

Query: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307
           +PGF  L  EDQI LLK+S IE+++L +   +  +    T   +D+ Y   D  +AG  +
Sbjct: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347

Query: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367
           E I P+ +F   +++L L + E+ LL+AI I S DRP VQ+   +EA+Q      L +Y 
Sbjct: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407

Query: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           R + P     L + +M+ KL  LR+L+  HS+Q   L  Q +   KL PL+ E++
Sbjct: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457


>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
           sapiens]
          Length = 472

 Score =  170 bits (430), Expect = 3e-42
 Identities = 121/400 (30%), Positives = 198/400 (49%), Gaps = 56/400 (14%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
           +C VCGDRA+G+H+NA+TCEGCKGFFRRS+ + A++ C   G+C +    RR CQ CRL+
Sbjct: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185

Query: 83  RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
           +C ++GM+ E +LT  E+Q K + + K  ++ A +         + +++ +       KT
Sbjct: 186 KCKEMGMLAECLLT--EIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT 243

Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
                                      P+ +    F  DS +                  
Sbjct: 244 ------------------------ELTPDQQTLLHFIMDSYNK----------QRMPQEI 269

Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
           +N  L EE S + +  L L++++   H+  LV ++        K +PGF+ L  EDQI L
Sbjct: 270 TNKILKEEFSAEENF-LILTEMA-TNHVQVLVEFT--------KKLPGFQTLDHEDQIAL 319

Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
           LK SA+E + LRS E F   +     G+ D       +  +G S E I P+  F   + +
Sbjct: 320 LKGSAVEAMFLRSAEIF---NKKLPSGHSD--LLEERIRNSGISDEYITPMFSFYKSIGE 374

Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
           L + +EE+ LL AI I+SPDR  ++D   +E +Q+ L + LQ   +   P    H  +A 
Sbjct: 375 LKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH--FAC 432

Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           ++ +L +LR+ N  H++    +S++     K TPL+ E++
Sbjct: 433 LLGRLTELRTFNHHHAEM--LMSWRVN-DHKFTPLLCEIW 469


>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  160 bits (406), Expect = 2e-39
 Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
           +C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C + G C I K  R  CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165

Query: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
            K+C+ +GM  + +L D +   KR++I + +E+   E L+ S+  +P+ ++E+  +I  +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225

Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
            +AH  T                  +  GSH  +   +  P   G             + 
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254

Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
           ++++     +D                 L    H   +++ +I +V+ FAK +P F +L 
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297

Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
            EDQI+LLK   +E++ LR+   +  +  + T   +    R     K G    + + +  
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355

Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
             + L   NL + E  LL A+ ++S DRPG+     IE  QD      + YI  R     
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411

Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
            H+   + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459


>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  160 bits (406), Expect = 2e-39
 Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
           +C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C + G C I K  R  CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165

Query: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
            K+C+ +GM  + +L D +   KR++I + +E+   E L+ S+  +P+ ++E+  +I  +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225

Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
            +AH  T                  +  GSH  +   +  P   G             + 
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254

Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
           ++++     +D                 L    H   +++ +I +V+ FAK +P F +L 
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297

Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
            EDQI+LLK   +E++ LR+   +  +  + T   +    R     K G    + + +  
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355

Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
             + L   NL + E  LL A+ ++S DRPG+     IE  QD      + YI  R     
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411

Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
            H+   + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459


>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  160 bits (406), Expect = 2e-39
 Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)

Query: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
           +C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C + G C I K  R  CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165

Query: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
            K+C+ +GM  + +L D +   KR++I + +E+   E L+ S+  +P+ ++E+  +I  +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225

Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
            +AH  T                  +  GSH  +   +  P   G             + 
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254

Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
           ++++     +D                 L    H   +++ +I +V+ FAK +P F +L 
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297

Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
            EDQI+LLK   +E++ LR+   +  +  + T   +    R     K G    + + +  
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355

Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
             + L   NL + E  LL A+ ++S DRPG+     IE  QD      + YI  R     
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411

Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
            H+   + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459


>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
           sapiens]
          Length = 410

 Score =  156 bits (394), Expect = 4e-38
 Identities = 115/411 (27%), Positives = 188/411 (45%), Gaps = 64/411 (15%)

Query: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
           C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C ++  C I K  R  CQ CR 
Sbjct: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
           K+C+ +GM  + +L D +   KR++I      +RKEE       RP+ + E+  +I I  
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172

Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
           +AH  T                  +  GSH      +    F  D         +   D 
Sbjct: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209

Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
           +D  +FS                             +++ +I +V+ FAK +P F +L  
Sbjct: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244

Query: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
           EDQI+LLK   +E++ LR+   +  +  + T   +    R  +  K G    + + + + 
Sbjct: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302

Query: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
              L   NL + E  LL A+ ++S DR G+     IE  Q+      + Y+  R H  P 
Sbjct: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362

Query: 376 SHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVFGNE 425
               + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF ++
Sbjct: 363 ---FWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVFEDQ 408


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  156 bits (394), Expect = 4e-38
 Identities = 117/425 (27%), Positives = 204/425 (48%), Gaps = 79/425 (18%)

Query: 2   EAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCP 61
           E M  S+  P P      V + C VC D+++G+H+   +CEGCKGFFRRS+++  ++TC 
Sbjct: 60  EEMVPSSPSPPPPP---RVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCH 116

Query: 62  FNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLR 121
            + +C I K  R  CQ CRL++C ++GM KE +  D   ++K+E+     +EE   DS  
Sbjct: 117 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRN-KKKKEV-----KEEGSPDSY- 169

Query: 122 PKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGD 181
            +LS + + +I  +  AH +    T+   CQ           G +               
Sbjct: 170 -ELSPQLEELITKVSKAHQE----TFPSLCQL----------GKY--------------- 199

Query: 182 SSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKV 241
           +++S +DH +             LDL   D                   ++L +  I K+
Sbjct: 200 TTNSSADHRV------------QLDLGLWDK-----------------FSELATKCIIKI 230

Query: 242 IGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSD 299
           + FAK +PGF  L+  DQI LLK++ ++++MLR    +T   D M+++ G        + 
Sbjct: 231 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG---LTLNRTQ 287

Query: 300 VTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRL 359
           +  AG    L + +  F   L  L + + E  LL AIC++  DR  +++   ++ +Q+ L
Sbjct: 288 MHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPL 346

Query: 360 SNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVL 419
              L+ Y R R   P    ++ +M+ K+ DLR ++ + ++  R ++ + E    + PL+ 
Sbjct: 347 LEALRLYARRRR--PSQPYMFPRMLMKITDLRGISTKGAE--RAITLKMEIPGPMPPLIR 402

Query: 420 EVFGN 424
           E+  N
Sbjct: 403 EMLEN 407


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  156 bits (394), Expect = 4e-38
 Identities = 117/425 (27%), Positives = 204/425 (48%), Gaps = 79/425 (18%)

Query: 2   EAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCP 61
           E M  S+  P P      V + C VC D+++G+H+   +CEGCKGFFRRS+++  ++TC 
Sbjct: 71  EEMVPSSPSPPPPP---RVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCH 127

Query: 62  FNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLR 121
            + +C I K  R  CQ CRL++C ++GM KE +  D   ++K+E+     +EE   DS  
Sbjct: 128 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRN-KKKKEV-----KEEGSPDSY- 180

Query: 122 PKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGD 181
            +LS + + +I  +  AH +    T+   CQ           G +               
Sbjct: 181 -ELSPQLEELITKVSKAHQE----TFPSLCQL----------GKY--------------- 210

Query: 182 SSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKV 241
           +++S +DH +             LDL   D                   ++L +  I K+
Sbjct: 211 TTNSSADHRV------------QLDLGLWDK-----------------FSELATKCIIKI 241

Query: 242 IGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSD 299
           + FAK +PGF  L+  DQI LLK++ ++++MLR    +T   D M+++ G        + 
Sbjct: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG---LTLNRTQ 298

Query: 300 VTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRL 359
           +  AG    L + +  F   L  L + + E  LL AIC++  DR  +++   ++ +Q+ L
Sbjct: 299 MHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPL 357

Query: 360 SNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVL 419
              L+ Y R R   P    ++ +M+ K+ DLR ++ + ++  R ++ + E    + PL+ 
Sbjct: 358 LEALRLYARRRR--PSQPYMFPRMLMKITDLRGISTKGAE--RAITLKMEIPGPMPPLIR 413

Query: 420 EVFGN 424
           E+  N
Sbjct: 414 EMLEN 418


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  150 bits (378), Expect = 3e-36
 Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)

Query: 20  VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
           +PRI   C VC D+++G+H+    CEGCKGFFRRS+++  ++TC  + +C I K  R  C
Sbjct: 81  LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 140

Query: 77  QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
           Q CRL++C ++GM KE +  D   ++K+E+    K E +   +L P++ E        L+
Sbjct: 141 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 188

Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
           +   K +  T+   CQ                    ++T +                   
Sbjct: 189 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 211

Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
                         +S +  V+L+   + +    ++L +  I K + FAK +PGF  LT 
Sbjct: 212 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 254

Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
            DQI LLK++ +++++LR    +T   D M+++ G        + +  AG    L + + 
Sbjct: 255 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 310

Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
            F   L  L + + E  LL AIC++  DR  ++    ++ +Q+ L   L+ Y+R R   P
Sbjct: 311 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 368

Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
               ++ KM+ K+ DLRS++ + ++  R ++ + E    + PL+ E+  N
Sbjct: 369 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 416


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  150 bits (378), Expect = 3e-36
 Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)

Query: 20  VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
           +PRI   C VC D+++G+H+    CEGCKGFFRRS+++  ++TC  + +C I K  R  C
Sbjct: 76  LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 135

Query: 77  QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
           Q CRL++C ++GM KE +  D   ++K+E+    K E +   +L P++ E        L+
Sbjct: 136 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 183

Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
           +   K +  T+   CQ                    ++T +                   
Sbjct: 184 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 206

Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
                         +S +  V+L+   + +    ++L +  I K + FAK +PGF  LT 
Sbjct: 207 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 249

Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
            DQI LLK++ +++++LR    +T   D M+++ G        + +  AG    L + + 
Sbjct: 250 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 305

Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
            F   L  L + + E  LL AIC++  DR  ++    ++ +Q+ L   L+ Y+R R   P
Sbjct: 306 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 363

Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
               ++ KM+ K+ DLRS++ + ++  R ++ + E    + PL+ E+  N
Sbjct: 364 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 411


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  150 bits (378), Expect = 3e-36
 Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)

Query: 20  VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
           +PRI   C VC D+++G+H+    CEGCKGFFRRS+++  ++TC  + +C I K  R  C
Sbjct: 81  LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 140

Query: 77  QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
           Q CRL++C ++GM KE +  D   ++K+E+    K E +   +L P++ E        L+
Sbjct: 141 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 188

Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
           +   K +  T+   CQ                    ++T +                   
Sbjct: 189 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 211

Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
                         +S +  V+L+   + +    ++L +  I K + FAK +PGF  LT 
Sbjct: 212 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 254

Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
            DQI LLK++ +++++LR    +T   D M+++ G        + +  AG    L + + 
Sbjct: 255 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 310

Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
            F   L  L + + E  LL AIC++  DR  ++    ++ +Q+ L   L+ Y+R R   P
Sbjct: 311 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 368

Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
               ++ KM+ K+ DLRS++ + ++  R ++ + E    + PL+ E+  N
Sbjct: 369 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 416


>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
           sapiens]
          Length = 490

 Score =  139 bits (350), Expect = 5e-33
 Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)

Query: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
           C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C ++  C I K  R  CQ CR 
Sbjct: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
           K+C+ +GM  + +L D +   KR++I      +RKEE       RP+ + E+  +I I  
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172

Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
           +AH  T                  +  GSH      +    F  D         +   D 
Sbjct: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209

Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
           +D  +FS                             +++ +I +V+ FAK +P F +L  
Sbjct: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244

Query: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
           EDQI+LLK   +E++ LR+   +  +  + T   +    R  +  K G    + + + + 
Sbjct: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302

Query: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
              L   NL + E  LL A+ ++S DR G+     IE  Q+      + Y+  R H  P 
Sbjct: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362

Query: 376 SHLLYAKMIQKLADLRS 392
               + K++ K  +++S
Sbjct: 363 ---FWPKLLMKEREVQS 376


>gi|117938756 constitutive androstane receptor isoform 1 [Homo
           sapiens]
          Length = 357

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score =  119 bits (297), Expect = 7e-27
 Identities = 69/186 (37%), Positives = 107/186 (57%), Gaps = 11/186 (5%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTK----AGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
            ++ CG    +Y + D  +     G  +E +E L  F   L+KL L E E+VLL A+ + 
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272

Query: 340 SP-----DRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLN 394
           SP     DRPGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+N
Sbjct: 273 SPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSIN 332

Query: 395 EEHSKQ 400
           E +  Q
Sbjct: 333 EAYGYQ 338


>gi|117938754 constitutive androstane receptor isoform 4 [Homo
           sapiens]
          Length = 314

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 53/177 (29%), Positives = 86/177 (48%), Gaps = 36/177 (20%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
            ++ CG    +Y + D  +A +                                    DR
Sbjct: 215 QNFLCG--PLRYTIEDGARAPY----------------------------------LTDR 238

Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 239 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 295


>gi|117938752 constitutive androstane receptor isoform 2 [Homo
           sapiens]
          Length = 352

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score =  125 bits (313), Expect = 1e-28
 Identities = 69/181 (38%), Positives = 107/181 (59%), Gaps = 6/181 (3%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKA----GHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
            ++ CG    +Y + D  +     G  +E +E L  F   L+KL L E E+VLL A+ + 
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272

Query: 340 SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSK 399
           SPDRPGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  
Sbjct: 273 SPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGY 332

Query: 400 Q 400
           Q
Sbjct: 333 Q 333


>gi|117938746 constitutive androstane receptor isoform 7 [Homo
           sapiens]
          Length = 339

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score =  102 bits (255), Expect = 5e-22
 Identities = 57/155 (36%), Positives = 90/155 (58%), Gaps = 6/155 (3%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKA----GHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
            ++ CG    +Y + D  +     G  +E +E L  F   L+KL L E E+VLL A+ + 
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272

Query: 340 SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
           SPDRPGV     I+ +Q+ ++ TLQ+YI+ +   P
Sbjct: 273 SPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 307


>gi|117938740 constitutive androstane receptor isoform 8 [Homo
           sapiens]
          Length = 296

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 41/151 (27%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
            ++ CG    +Y + D  +                                       DR
Sbjct: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233

Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
           PGV     I+ +Q+ ++ TLQ+YI+ +   P
Sbjct: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 264


>gi|117938734 constitutive androstane receptor isoform 5 [Homo
           sapiens]
          Length = 309

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 41/177 (23%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
            ++ CG    +Y + D  +                                       DR
Sbjct: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233

Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 290


>gi|117938729 constitutive androstane receptor isoform 6 [Homo
           sapiens]
          Length = 340

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score =  102 bits (254), Expect = 7e-22
 Identities = 57/156 (36%), Positives = 90/156 (57%), Gaps = 7/156 (4%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSP-- 341
            ++ CG    +Y + D  + G  +E +E L  F   L+KL L E E+VLL A+ + SP  
Sbjct: 215 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAP 272

Query: 342 ---DRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
              DRPGV     I+ +Q+ ++ TLQ+YI+ +   P
Sbjct: 273 YLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 308


>gi|4826661 constitutive androstane receptor isoform 3 [Homo
           sapiens]
          Length = 348

 Score =  139 bits (350), Expect = 5e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68

Query: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123

Query: 142 TYDPTYSDFCQFRPPVRV 159
                +  F QFRPP  +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141



 Score =  130 bits (328), Expect = 2e-30
 Identities = 69/177 (38%), Positives = 107/177 (60%), Gaps = 2/177 (1%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
            ++ CG    +Y + D  + G  +E +E L  F   L+KL L E E+VLL A+ + SPDR
Sbjct: 215 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDR 272

Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 273 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 329


>gi|50348666 peroxisome proliferative activated receptor, alpha
           [Homo sapiens]
          Length = 468

 Score =  136 bits (343), Expect = 3e-32
 Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)

Query: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
           C +CGD+A+G+H+    CEGCKGFFRR+++ K ++    +  C+I K NR  CQ CR  +
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160

Query: 84  CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
           C+ +GM    I         R   + R E+  LK  +     + +    A L     + Y
Sbjct: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211

Query: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
           +    +F   +   RV   G +      S + P    D  + C         M + +  +
Sbjct: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256

Query: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
            L  +   + +  V +         H     S  ++ ++  FAK IPGF +L   DQ+ L
Sbjct: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308

Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
           LK    E I    +     D M    GN  +  R    +      +++EP   F +    
Sbjct: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367

Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
           L L + +  L +A  I   DRPG+ +   IE +Q+ + + L+ +++  H  P    L+ K
Sbjct: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425

Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           ++QK+ADLR L  EH++  + +  + E    L PL+ E++
Sbjct: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464


>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
           sapiens]
          Length = 468

 Score =  136 bits (343), Expect = 3e-32
 Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)

Query: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
           C +CGD+A+G+H+    CEGCKGFFRR+++ K ++    +  C+I K NR  CQ CR  +
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160

Query: 84  CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
           C+ +GM    I         R   + R E+  LK  +     + +    A L     + Y
Sbjct: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211

Query: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
           +    +F   +   RV   G +      S + P    D  + C         M + +  +
Sbjct: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256

Query: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
            L  +   + +  V +         H     S  ++ ++  FAK IPGF +L   DQ+ L
Sbjct: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308

Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
           LK    E I    +     D M    GN  +  R    +      +++EP   F +    
Sbjct: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367

Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
           L L + +  L +A  I   DRPG+ +   IE +Q+ + + L+ +++  H  P    L+ K
Sbjct: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425

Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
           ++QK+ADLR L  EH++  + +  + E    L PL+ E++
Sbjct: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464


>gi|117938750 constitutive androstane receptor isoform 10 [Homo
           sapiens]
          Length = 319

 Score =  130 bits (328), Expect = 2e-30
 Identities = 69/177 (38%), Positives = 107/177 (60%), Gaps = 2/177 (1%)

Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 126 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 185

Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
            ++ CG    +Y + D  + G  +E +E L  F   L+KL L E E+VLL A+ + SPDR
Sbjct: 186 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDR 243

Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 244 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 300



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 5/111 (4%)

Query: 49  RRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIL 108
           RR++ +    TCPF G C ++K  RRHC ACRL++C+D GM K+ IL+ E +  +R    
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 109 KRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRV 159
           +R+ ++        +LS+EQ+ +I  LL AH +     +  F QFRPP  +
Sbjct: 67  QRRAQQT-----PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHL 112


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,350,489
Number of Sequences: 37866
Number of extensions: 775167
Number of successful extensions: 3954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 3228
Number of HSP's gapped (non-prelim): 534
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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