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Search of human proteins with 63003903
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
(277 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 562 e-160
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 192 3e-49
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 105 3e-23
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 101 8e-22
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 101 8e-22
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 100 2e-21
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 99 4e-21
gi|238908508 leucine-rich repeat and death domain-containing pro... 97 2e-20
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 96 4e-20
gi|45827729 scribble isoform b [Homo sapiens] 94 1e-19
gi|45827731 scribble isoform a [Homo sapiens] 94 1e-19
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 92 4e-19
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 92 5e-19
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 92 5e-19
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 92 6e-19
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 88 9e-18
gi|62241040 leucine rich repeat containing 8 family, member A [H... 88 9e-18
gi|187829877 leucine rich repeat containing 8 family, member A [... 88 9e-18
gi|187829871 leucine rich repeat containing 8 family, member A [... 88 9e-18
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 84 1e-16
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 83 2e-16
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 83 2e-16
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 82 7e-16
gi|61742786 leucine rich repeat and death domain containing prot... 80 1e-15
gi|61742784 leucine rich repeat and death domain containing prot... 80 1e-15
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 79 3e-15
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 79 3e-15
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 79 4e-15
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 79 4e-15
gi|197333706 leucine rich repeat containing 8 family, member D [... 78 7e-15
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 562 bits (1448), Expect = e-160
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS 60
MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS
Sbjct: 1 MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS 60
Query: 61 DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL 120
DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL
Sbjct: 61 DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL 120
Query: 121 QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLT 180
QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLT
Sbjct: 121 QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLT 180
Query: 181 DFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRW 240
DFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRW
Sbjct: 181 DFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRW 240
Query: 241 AEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS 277
AEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS
Sbjct: 241 AEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS 277
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 192 bits (488), Expect = 3e-49
Identities = 107/243 (44%), Positives = 144/243 (59%), Gaps = 9/243 (3%)
Query: 31 DKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
D+ ++LSG +LRR P VC+ L KLY+S L LP E+ +L+ L+ILALDFN + L
Sbjct: 23 DQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERL 82
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P +C L +L LYLG N+L LP++ + LQ+LR LWIE N L + P + L L++L
Sbjct: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAH 210
G N LR LP +L R+ LR +WL GNR +FP LL M L ++D+D N + FP L
Sbjct: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHP 202
Query: 211 LSSLKLVIYDHNPCRNAPKVAKGVRRVGRWA--------EETPEPDPRKARRYALVREES 262
L +L++ YDHNP P+VA V VG A E TP P PR+ R A EE
Sbjct: 203 LRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAERDEPTPRPPPRRPAR-AFEDEEE 261
Query: 263 QEL 265
++L
Sbjct: 262 EDL 264
Score = 53.9 bits (128), Expect = 1e-07
Identities = 39/121 (32%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 112 DLPS--ELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQEL 169
+LPS E L + L + L +LP VC LS L+ L+ LR LP ++ L+EL
Sbjct: 10 ELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELREL 69
Query: 170 RTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
R + L N+L P L +P L + + N + P+ A L SL+ + + N R P
Sbjct: 70 RILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFP 129
Query: 229 K 229
+
Sbjct: 130 R 130
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 105 bits (263), Expect = 3e-23
Identities = 71/211 (33%), Positives = 115/211 (54%), Gaps = 5/211 (2%)
Query: 23 RDLREMPLDKMVDLSGSQLRR----FPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQ 78
RD R + M +S S + R P + E+ KL LS N L LPPE+G+L +
Sbjct: 38 RDPRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIV 97
Query: 79 ILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPD 138
+L L N K+LP+ V L+ L +L++ N L ++P+ELSL + L L + NCL+QLP
Sbjct: 98 VLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPA 157
Query: 139 VVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVD 198
+LS L+ L+ +N +P + L+EL + + NRL + + H+ L++ +
Sbjct: 158 CFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAE 217
Query: 199 WNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
N+I FP SL ++SL+L+ ++N + P
Sbjct: 218 GNNIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
Score = 65.9 bits (159), Expect = 4e-11
Identities = 48/174 (27%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Query: 1 MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS 60
+G R +V + +R ++ + R++ + K++ ++ + L P + R+L L LS
Sbjct: 90 VGKLTRIVVLNLCGNRLKS-LPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLS 148
Query: 61 DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL 120
N L+ LP L L+ L L N F +P V +LK+L L++G+N+L ++ + L
Sbjct: 149 HNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHL 208
Query: 121 QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQEL-RTIW 173
+L+ E N + P +C ++ L+ L+ +N ++ LP +L L L R W
Sbjct: 209 ASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAW 262
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 101 bits (251), Expect = 8e-22
Identities = 72/209 (34%), Positives = 108/209 (51%), Gaps = 4/209 (1%)
Query: 21 VVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQIL 80
VV LRE+ + ++LS +QL P + + L +L +S N L LP L L L+ L
Sbjct: 130 VVSALREL---RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTL 186
Query: 81 ALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVV 140
+D N A P+ + L L L + +N+L LP ++S L+ L+ LW+ L LP
Sbjct: 187 DVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGF 246
Query: 141 CELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWN 200
CEL+ L++L +N L+ LP Q LQ L+ + LS N +FP LL + LE + + N
Sbjct: 247 CELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
Query: 201 SIRYFPSL-AHLSSLKLVIYDHNPCRNAP 228
+ PSL + L L + D+N R P
Sbjct: 307 QLTSVPSLISGLGRLLTLWLDNNRIRYLP 335
Score = 93.2 bits (230), Expect = 2e-19
Identities = 67/230 (29%), Positives = 103/230 (44%), Gaps = 3/230 (1%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
+ +D+ +QL FP + L +L +S N L LP ++ L+ L+IL L LP
Sbjct: 184 RTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLP 243
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
C L L L L NN L LP++ S LQ L+ L + +N + P + L+ L+ L+
Sbjct: 244 AGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYL 303
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS-LAH 210
N L +P + L L T+WL NR+ P ++ + LE + + N I P
Sbjct: 304 SRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ 363
Query: 211 LSSLKLVIYDHNPCRNAP--KVAKGVRRVGRWAEETPEPDPRKARRYALV 258
LS + L NP P KG+ + + +E P R L+
Sbjct: 364 LSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLL 413
Score = 84.0 bits (206), Expect = 1e-16
Identities = 56/152 (36%), Positives = 80/152 (52%), Gaps = 10/152 (6%)
Query: 25 LREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNL 77
LR +P D K++ LSG++L P C L L L +N L +LP + LQ L
Sbjct: 216 LRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRL 275
Query: 78 QILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLP 137
++L L N F+ P + L L LYL N+L +PS +S L L TLW++ N + LP
Sbjct: 276 KMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLP 335
Query: 138 DVVCELSLLKTLHAGSNALRLLP---GQLRRL 166
D + EL+ L+ L N + +LP GQL R+
Sbjct: 336 DSIVELTGLEELVLQGNQIAVLPDHFGQLSRV 367
Score = 82.8 bits (203), Expect = 3e-16
Identities = 52/161 (32%), Positives = 84/161 (52%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
R L ++ + +D+S ++LR P + + R L L+LS L +LP +L +L+ L L
Sbjct: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257
Query: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
D N +ALP L++L +L L +N + P+ L L L L++ N LT +P ++
Sbjct: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317
Query: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFP 183
L L TL +N +R LP + L L + L GN++ P
Sbjct: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLP 358
Score = 72.0 bits (175), Expect = 5e-13
Identities = 56/175 (32%), Positives = 88/175 (50%), Gaps = 3/175 (1%)
Query: 57 LYLSDNHLNSLPPELGQL-QNLQILALDFNNFKAL-PQVVCTLKQLCILYLGNNKLCDLP 114
L L N LPP + +L +L L + N AL +VV L++L L L +N+L LP
Sbjct: 92 LVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALP 151
Query: 115 SELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWL 174
++L L +L L + N L LPD + LS L+TL N L P QL +L L + +
Sbjct: 152 AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDV 211
Query: 175 SGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
S NRL P + + L+++ + + P+ L+SL+ ++ D+N + P
Sbjct: 212 SSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALP 266
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 101 bits (251), Expect = 8e-22
Identities = 62/187 (33%), Positives = 97/187 (51%), Gaps = 2/187 (1%)
Query: 41 LRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQL 100
L + P + F+ L+ L LS N ++ +PP +G L LQ L L +N K +P+ + L
Sbjct: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
Query: 101 CILYLGNNK-LCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLL 159
L L N+ +CDLP ELS L L L + N T +P V + L+ L GSN L L
Sbjct: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 160 PGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVI 218
P + R+Q L T+WL N +T P + +M L + + N ++ P + +++L+ V
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
Query: 219 YDHNPCR 225
+ NP +
Sbjct: 275 FRDNPLK 281
Score = 76.3 bits (186), Expect = 3e-14
Identities = 54/177 (30%), Positives = 85/177 (48%), Gaps = 13/177 (7%)
Query: 16 RCQNYVVRDLREMPLDKM------------VDLSGSQLRRFPLHVCSFRELVKLYLSDNH 63
R QN +V DL + ++ + LS ++++ P + + L KL L+ N
Sbjct: 104 RFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNR 163
Query: 64 -LNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQN 122
+ LP EL L L L L N+F +P V + L L +G+NKL LP + +QN
Sbjct: 164 DICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQN 223
Query: 123 LRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRL 179
L TLW++ N +T LP + + L TL +N L+ +P + + LR + N L
Sbjct: 224 LHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 53.1 bits (126), Expect = 3e-07
Identities = 47/211 (22%), Positives = 87/211 (41%), Gaps = 25/211 (11%)
Query: 53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
+LV+++ L L ++ + IL ++ +K LP + L QL L L
Sbjct: 38 KLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLK 97
Query: 113 LPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRL-------------- 158
+P + QNL L + N ++++P + L+ L+ L N ++
Sbjct: 98 IPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKL 157
Query: 159 ----------LPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-S 207
LP +L L +L + LS N T P +L+MP LE +D+ N + P +
Sbjct: 158 ELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDT 217
Query: 208 LAHLSSLKLVIYDHNPCRNAPKVAKGVRRVG 238
+ + +L + N P+ ++ +G
Sbjct: 218 IERMQNLHTLWLQRNEITCLPQTISNMKNLG 248
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 100 bits (248), Expect = 2e-21
Identities = 64/200 (32%), Positives = 102/200 (51%), Gaps = 4/200 (2%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+ LSG++L + P +C + L LYL + L+ L L NL+ L L N+ P
Sbjct: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQ 321
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+C LK L +L L +NK+ LPSEL L L+ L + N P+ V L+ L+ L+ G
Sbjct: 322 ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
Query: 154 N---ALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLA 209
+ L +P +R+LQ L+ +++ N L P L MP LEV+D N ++ P ++
Sbjct: 382 DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAIC 441
Query: 210 HLSSLKLVIYDHNPCRNAPK 229
+LK + + N + P+
Sbjct: 442 QAQALKELRLEDNLLTHLPE 461
Score = 95.5 bits (236), Expect = 4e-20
Identities = 59/183 (32%), Positives = 91/183 (49%), Gaps = 1/183 (0%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
L +Q FP +C L + L +N + ++P E+G L LQ + NN LP +C
Sbjct: 172 LKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLC 231
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
QL +L L +N L +P + L+ + + + N L ++P ++C + L L+ G+
Sbjct: 232 QCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTG 291
Query: 156 LRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSL 214
L L G R L LR + LS N L P + + LEV+ +D N I PS L LS L
Sbjct: 292 LHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKL 351
Query: 215 KLV 217
K++
Sbjct: 352 KIL 354
Score = 90.9 bits (224), Expect = 1e-18
Identities = 60/178 (33%), Positives = 84/178 (47%), Gaps = 26/178 (14%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
+ +DLS + L PL +C+ + L L L DN + LP ELG L L+IL L N F + P
Sbjct: 306 RFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFP 365
Query: 92 QVVCTLKQLCILYLGNN---KLCDLPSELSLLQNLRTLWIEAN----------------- 131
+ V +L L LY+G + KL +P + LQ+L+ L+IE N
Sbjct: 366 EEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEV 425
Query: 132 ------CLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFP 183
L QLPD +C+ LK L N L LP L L L+ + L N + + P
Sbjct: 426 LDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
Score = 87.8 bits (216), Expect = 9e-18
Identities = 58/197 (29%), Positives = 94/197 (47%), Gaps = 4/197 (2%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
++ + L P +C +L L LS N L+S+P +L+ + + L N + +P+++C
Sbjct: 218 MASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
L +LYLGN L L L NLR L + N L P +C L L+ L N
Sbjct: 278 RWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNK 337
Query: 156 LRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWN---SIRYFPS-LAHL 211
+ LP +L L +L+ + L+GN FP +L + LE + + + + Y P + L
Sbjct: 338 IGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKL 397
Query: 212 SSLKLVIYDHNPCRNAP 228
SLK + ++N P
Sbjct: 398 QSLKELYIENNHLEYLP 414
Score = 85.1 bits (209), Expect = 6e-17
Identities = 59/185 (31%), Positives = 97/185 (52%), Gaps = 3/185 (1%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+D S L PL + +F EL +++L +N + +P E+ +L+N+++L LD NN ++L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 94 VCTLKQLCILYLGNNKLCDLP-SELSLLQNLRTLWIEANCLTQLPDVVCE-LSLLKTLHA 151
+ L L L L N + +S L LR L + L ++P V+ + L L+ L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAH 210
N L+ LP ++ +LR I+L N+ FP L + LE+ID+D N I P + H
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
Query: 211 LSSLK 215
L+ L+
Sbjct: 210 LTGLQ 214
Score = 69.3 bits (168), Expect = 3e-12
Identities = 38/104 (36%), Positives = 54/104 (51%)
Query: 38 GSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTL 97
G +L P H+ + L +LY+ +NHL LP LG + NL++L N K LP +C
Sbjct: 384 GFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQA 443
Query: 98 KQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVC 141
+ L L L +N L LP L L NL+ L + N + + P VC
Sbjct: 444 QALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVC 487
Score = 44.7 bits (104), Expect = 9e-05
Identities = 26/76 (34%), Positives = 40/76 (52%)
Query: 20 YVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQI 79
Y+ L MP +++D + L++ P +C + L +L L DN L LP L L NL++
Sbjct: 412 YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKV 471
Query: 80 LALDFNNFKALPQVVC 95
L L N + P+ VC
Sbjct: 472 LTLMDNPMEEPPKEVC 487
Score = 37.7 bits (86), Expect = 0.011
Identities = 28/98 (28%), Positives = 47/98 (47%)
Query: 20 YVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQI 79
YV +R++ K + + + L P+ + S L L N L LP + Q Q L+
Sbjct: 389 YVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE 448
Query: 80 LALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSEL 117
L L+ N LP+ + +L L +L L +N + + P E+
Sbjct: 449 LRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 99.0 bits (245), Expect = 4e-21
Identities = 68/221 (30%), Positives = 106/221 (47%), Gaps = 24/221 (10%)
Query: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
+++ S + + + P L +LYL+D L LP G+L L+IL L N+ K LP+
Sbjct: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
Query: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSL------- 145
+ L QL L LGNN+ +LP L +QNLR LW++ N L LP + +L +
Sbjct: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
Query: 146 ----------------LKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHM 189
L+ L SN L+ LP + L++L T+ + N+LT P + ++
Sbjct: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNL 298
Query: 190 PFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAPK 229
LE D N + PS + +L SL+ + D N P+
Sbjct: 299 SLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPR 339
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/221 (27%), Positives = 99/221 (44%), Gaps = 24/221 (10%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
++++L + L+ P + +L +L L +N LP L Q+QNL+ L +D N + LP
Sbjct: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
Query: 92 QVVCTLKQLCI-----------------------LYLGNNKLCDLPSELSLLQNLRTLWI 128
+ LK L L L +N L LP + LL+ L TL +
Sbjct: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
Query: 129 EANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLH 188
+ N LT LP+ + LSLL+ N L LP + L LRT+ + N L + P +
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
Query: 189 MPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
+ V+ + N + + P + + L+++ N +N P
Sbjct: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 77.0 bits (188), Expect = 2e-14
Identities = 43/143 (30%), Positives = 74/143 (51%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
LS + L++ P + ++L L + DN L LP +G L L+ N ++LP +
Sbjct: 260 LSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIG 319
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
L L L + N L +LP E+ +N+ + + +N L LP+ + ++ L+ L+ N
Sbjct: 320 YLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNR 379
Query: 156 LRLLPGQLRRLQELRTIWLSGNR 178
L+ LP +L+EL +WLS N+
Sbjct: 380 LKNLPFSFTKLKELAALWLSDNQ 402
Score = 75.9 bits (185), Expect = 4e-14
Identities = 55/197 (27%), Positives = 92/197 (46%), Gaps = 8/197 (4%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
R L E+ LD +Q+ P + + + L KL + DN L++LP + L NL+ L +
Sbjct: 46 RTLEELYLD------ANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDI 99
Query: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
N + P+ + K L I+ N + LP + L NL L++ L LP
Sbjct: 100 SKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGR 159
Query: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
L L+ L N L+ LP + +L +L + L N + P VL + L + +D N++
Sbjct: 160 LVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL 219
Query: 203 RYFPSLAHLSSLKLVIY 219
+ P + LK+++Y
Sbjct: 220 QVLP--GSIGKLKMLVY 234
Score = 57.0 bits (136), Expect = 2e-08
Identities = 29/97 (29%), Positives = 53/97 (54%)
Query: 35 DLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVV 94
D S ++L P + L L + +N L LP E+G +N+ +++L N + LP+ +
Sbjct: 305 DCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI 364
Query: 95 CTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEAN 131
+++L +L L +N+L +LP + L+ L LW+ N
Sbjct: 365 GQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Score = 33.1 bits (74), Expect = 0.27
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 12/65 (18%)
Query: 17 CQNYVVRDLREMPLD------------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
C+N V LR L+ ++++LS ++L+ P +EL L+LSDN
Sbjct: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQS 403
Query: 65 NSLPP 69
+L P
Sbjct: 404 KALIP 408
Score = 32.3 bits (72), Expect = 0.47
Identities = 20/58 (34%), Positives = 30/58 (51%)
Query: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
++ L ++L P + ++L L LSDN L +LP +L+ L L L N KAL
Sbjct: 349 VMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 97.1 bits (240), Expect = 2e-20
Identities = 65/226 (28%), Positives = 116/226 (51%), Gaps = 7/226 (3%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
K +DL +Q+++ P + + L L L N + P EL L+NLQ+L L N + +
Sbjct: 536 KYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKIS 595
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTL---WIEANCLTQLPDVVCELSLLKT 148
+C LK + L +N+ P EL LQ+L L I+ LT+LP + ++ LK
Sbjct: 596 SDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE 655
Query: 149 LHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS- 207
L +NA+R +P + L+ L ++ N+++ P LL + L+ +++ N++ PS
Sbjct: 656 LDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSA 715
Query: 208 LAHLSSLKLVIYDHNPCRNAP-KVAKG--VRRVGRWAEETPEPDPR 250
+ ++ SLK + +D NP P ++ KG + + R+ + E D +
Sbjct: 716 IYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEK 761
Score = 95.9 bits (237), Expect = 3e-20
Identities = 62/191 (32%), Positives = 96/191 (50%), Gaps = 2/191 (1%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLP-PELGQLQNLQILALDFNNFKALPQ 92
V+L L+ FP + + + LYL N + + + G L L+IL+L N +LP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAG 152
+ L L IL + +N + +P E+S L N+R L+ N + P + L L+ L G
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 153 SNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHL 211
N LR +P L L+ LR + L N+LT FP L +P L +D+ N I P + L
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIREL 325
Query: 212 SSLKLVIYDHN 222
+L+ ++ DHN
Sbjct: 326 KNLETLLMDHN 336
Score = 86.3 bits (212), Expect = 3e-17
Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 1/199 (0%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
+++ L + L P + L L +S NH++ +P E+ QL N++ L N + P
Sbjct: 191 EILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP 250
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
+ L L IL LG NKL +P L L+ LR L +E N LT P +C L L +L
Sbjct: 251 SDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDL 310
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAH 210
N + LP ++R L+ L T+ + N+LT + + ++ + + N + + +
Sbjct: 311 TGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
Query: 211 LSSLKLVIYDHNPCRNAPK 229
L+++I D N +N P+
Sbjct: 371 FRELRILILDKNLLKNIPE 389
Score = 85.5 bits (210), Expect = 5e-17
Identities = 61/221 (27%), Positives = 105/221 (47%), Gaps = 24/221 (10%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
++++L +QL FP +C +L+ L L+ N ++SLP E+ +L+NL+ L +D N L
Sbjct: 283 RVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLA 342
Query: 92 QVVCTL-----------------------KQLCILYLGNNKLCDLPSELSLLQNLRTLWI 128
+ L ++L IL L N L ++P ++S L L +
Sbjct: 343 VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402
Query: 129 EANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLH 188
N LT+LP + +L+ L+ LH N + + + L + ++ SGN +TD P + +
Sbjct: 403 SDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKN 462
Query: 189 MPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
+ I++ +N I YFP L L SL + + N P
Sbjct: 463 CQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
Score = 83.6 bits (205), Expect = 2e-16
Identities = 53/205 (25%), Positives = 99/205 (48%), Gaps = 1/205 (0%)
Query: 19 NYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQ 78
+++ +++ ++ + + + + FP + L L L N L +P L L+ L+
Sbjct: 224 SHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLR 283
Query: 79 ILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPD 138
+L L++N P+ +C L +L L L N + LP E+ L+NL TL ++ N LT L
Sbjct: 284 VLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV 343
Query: 139 VVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVD 198
+ +L +K L N L ++ ++ +ELR + L N L + P + LE + +
Sbjct: 344 EIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLS 403
Query: 199 WNSIRYFPSLAH-LSSLKLVIYDHN 222
N + P H L++L+ + + N
Sbjct: 404 DNKLTELPKYIHKLNNLRKLHVNRN 428
Score = 80.5 bits (197), Expect = 1e-15
Identities = 56/211 (26%), Positives = 105/211 (49%), Gaps = 9/211 (4%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
+++RE+ + + + ++L + + ++ +L L+DN L + ++ + L+IL L
Sbjct: 320 KEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILIL 379
Query: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
D N K +P+ + L L L +NKL +LP + L NLR L + N + ++ D +
Sbjct: 380 DKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
Query: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
L+ + +L N + +P +++ Q++ I LS N++ FP L + L + V+ N I
Sbjct: 440 LNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYI 499
Query: 203 RYFP-------SLAH--LSSLKLVIYDHNPC 224
P L H LS KL+I+ + C
Sbjct: 500 SEIPVDISFSKQLLHLELSENKLLIFSEHFC 530
Score = 76.3 bits (186), Expect = 3e-14
Identities = 55/199 (27%), Positives = 94/199 (47%), Gaps = 26/199 (13%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELG--------------------- 72
++LS +++ FPL +C+ L L ++ N+++ +P ++
Sbjct: 469 IELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEH 528
Query: 73 --QLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEA 130
L NL+ L L N K +P + + L +L L NK P EL L+NL+ L +
Sbjct: 529 FCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSE 588
Query: 131 NCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLS---GNRLTDFPTVLL 187
N L ++ +C L ++ L+ SN P +L +LQ L + +S G +LT P L
Sbjct: 589 NQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648
Query: 188 HMPFLEVIDVDWNSIRYFP 206
+M L+ +D+ N+IR P
Sbjct: 649 NMTQLKELDISNNAIREIP 667
Score = 72.0 bits (175), Expect = 5e-13
Identities = 56/208 (26%), Positives = 96/208 (46%), Gaps = 7/208 (3%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
R+LR + LDK + L+ P + L L LSDN L LP + +L NL+ L +
Sbjct: 372 RELRILILDKNL------LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
+ NN + + L +C L N + D+P E+ Q + + + N + P +C
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485
Query: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
L L L N + +P + ++L + LS N+L F + L+ +D+ N I
Sbjct: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545
Query: 203 RYFP-SLAHLSSLKLVIYDHNPCRNAPK 229
+ P S++++ SL ++I N P+
Sbjct: 546 KKIPASISNMISLHVLILCCNKFETFPR 573
Score = 66.6 bits (161), Expect = 2e-11
Identities = 49/213 (23%), Positives = 92/213 (43%), Gaps = 24/213 (11%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDN----------HLNSL-------------PPE 70
+ LS ++L P ++ L KL+++ N HLN++ P E
Sbjct: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459
Query: 71 LGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEA 130
+ Q + + L +N P +C L L L + N + ++P ++S + L L +
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSE 519
Query: 131 NCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMP 190
N L + C L LK L G N ++ +P + + L + L N+ FP L +
Sbjct: 520 NKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLE 579
Query: 191 FLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHN 222
L+V+D+ N ++ S + +L ++ + + N
Sbjct: 580 NLQVLDLSENQLQKISSDICNLKGIQKLNFSSN 612
Score = 63.5 bits (153), Expect = 2e-10
Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 1/183 (0%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
++ SG+ + P+ + + ++++K+ LS N + P L L +L L+++ N +P
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ KQL L L NKL L NL+ L + N + ++P + + L L
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
Query: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLS 212
N P +L L+ L+ + LS N+L + + ++ ++ ++ N +FP L L
Sbjct: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
Query: 213 SLK 215
SL+
Sbjct: 626 SLE 628
Score = 54.7 bits (130), Expect = 9e-08
Identities = 33/103 (32%), Positives = 52/103 (50%)
Query: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
+L M K +D+S + +R P ++ R LV L+ +N ++ LPP L L +LQ L L
Sbjct: 646 ELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLS 705
Query: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTL 126
NN ALP + + L + +N L P E+ + L T+
Sbjct: 706 GNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTI 748
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 95.5 bits (236), Expect = 4e-20
Identities = 61/212 (28%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 25 LREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNL 77
LRE+P + + LS ++++R P + +F +LV+L +S N + +P + + L
Sbjct: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107
Query: 78 QILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLP 137
Q+ N LP+ L+ L L + + L LP + L NL +L + N LT LP
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Query: 138 DVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDV 197
D + +L L+ L G+N + LP + L L+ +WL GN+L++ P + ++ L +DV
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 198 DWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
N + P ++ L+SL ++ N P
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIP 259
Score = 95.5 bits (236), Expect = 4e-20
Identities = 62/199 (31%), Positives = 96/199 (48%), Gaps = 1/199 (0%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
++ D SG+ L R P + L L ++D L SLP +G L NL L L N LP
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
+ L++L L LGNN++ +LP + L +L+ LW++ N L++LP + L L L
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAH 210
N L LP ++ L L + +S N L P + + L ++ VD N + P ++
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGE 287
Query: 211 LSSLKLVIYDHNPCRNAPK 229
SL ++ N PK
Sbjct: 288 CESLTELVLTENQLLTLPK 306
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/181 (31%), Positives = 89/181 (49%), Gaps = 2/181 (1%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
L G+QL P + + + L+ L +S+N L LP E+ L +L L + N + +P +
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
LK+L IL + N+L LP + ++L L + N L LP + +L L L+A N
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
Query: 156 LRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLK 215
L LP ++ L + NRLT P + L V+DV N + + P L++LK
Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP--LSLTALK 381
Query: 216 L 216
L
Sbjct: 382 L 382
Score = 79.0 bits (193), Expect = 4e-15
Identities = 54/173 (31%), Positives = 83/173 (47%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
++L + L P + R L +L L +N + +LP +G L +L+ L LD N LPQ
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ LK L L + N+L LP E+S L +L L I N L +PD + +L L L
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275
Query: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP 206
N L LP + + L + L+ N+L P + + L ++ D N + P
Sbjct: 276 NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLP 328
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 94.0 bits (232), Expect = 1e-19
Identities = 67/190 (35%), Positives = 96/190 (50%), Gaps = 7/190 (3%)
Query: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
+LRE+ LD+ +QL P + + R LV L +S+N L LP ELG L L L L
Sbjct: 198 NLRELWLDR------NQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCEL 143
N + LP + LKQL IL + N+LC++ + +NL L + N L LP + +L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 144 SLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
+ L L+ N L LP ++ L + L NRL P L H L V+DV N ++
Sbjct: 312 TKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
Query: 204 YFP-SLAHLS 212
P +L HL+
Sbjct: 372 SLPFALTHLN 381
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/171 (36%), Positives = 84/171 (49%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
++ D SG+ L R P R L L L+D L +LP ++G L NL L L N K+LP
Sbjct: 108 EIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
+ L +L L LG N L LP L L NLR LW++ N L+ LP + L L L
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
N L LP +L L L + LS N L P + + L ++ VD N +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 87.8 bits (216), Expect = 9e-18
Identities = 66/212 (31%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 25 LREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNL 77
LRE+P + + LS ++++R P V +F +LV+L +S N + +P + + L
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKAL 107
Query: 78 QILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLP 137
+I N LP L+ L L L + L LP ++ L NL TL + N L LP
Sbjct: 108 EIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 138 DVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDV 197
+ L L+ L G N L +LP L L LR +WL N+L+ P L ++ L +DV
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 198 DWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
N + P+ L L L ++ N R P
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Score = 75.5 bits (184), Expect = 5e-14
Identities = 67/225 (29%), Positives = 98/225 (43%), Gaps = 13/225 (5%)
Query: 17 CQNYVVRDLREMPLDKMVD------------LSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
C+ + D PL ++ D L+ L+ P V + LV L L +N L
Sbjct: 104 CKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLL 163
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
SLP L L L+ L L N+ + LP + L L L+L N+L LP EL L+ L
Sbjct: 164 KSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 125 TLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPT 184
L + N L +LP + L LL L N LR LP + +L++L + + NRL +
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 185 VLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
+ L + + N + P SL L+ L + D N P
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/92 (36%), Positives = 50/92 (54%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDL 113
L +L L++N L +LP LG+L L L +D N+ +ALP + L +L L +N+L L
Sbjct: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL 350
Query: 114 PSELSLLQNLRTLWIEANCLTQLPDVVCELSL 145
P EL+ L L + N L LP + L+L
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHLNL 382
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 94.0 bits (232), Expect = 1e-19
Identities = 67/190 (35%), Positives = 96/190 (50%), Gaps = 7/190 (3%)
Query: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
+LRE+ LD+ +QL P + + R LV L +S+N L LP ELG L L L L
Sbjct: 198 NLRELWLDR------NQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCEL 143
N + LP + LKQL IL + N+LC++ + +NL L + N L LP + +L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 144 SLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
+ L L+ N L LP ++ L + L NRL P L H L V+DV N ++
Sbjct: 312 TKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
Query: 204 YFP-SLAHLS 212
P +L HL+
Sbjct: 372 SLPFALTHLN 381
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/171 (36%), Positives = 84/171 (49%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
++ D SG+ L R P R L L L+D L +LP ++G L NL L L N K+LP
Sbjct: 108 EIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
+ L +L L LG N L LP L L NLR LW++ N L+ LP + L L L
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
N L LP +L L L + LS N L P + + L ++ VD N +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 87.8 bits (216), Expect = 9e-18
Identities = 66/212 (31%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 25 LREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNL 77
LRE+P + + LS ++++R P V +F +LV+L +S N + +P + + L
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKAL 107
Query: 78 QILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLP 137
+I N LP L+ L L L + L LP ++ L NL TL + N L LP
Sbjct: 108 EIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 138 DVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDV 197
+ L L+ L G N L +LP L L LR +WL N+L+ P L ++ L +DV
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 198 DWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
N + P+ L L L ++ N R P
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Score = 75.5 bits (184), Expect = 5e-14
Identities = 67/225 (29%), Positives = 98/225 (43%), Gaps = 13/225 (5%)
Query: 17 CQNYVVRDLREMPLDKMVD------------LSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
C+ + D PL ++ D L+ L+ P V + LV L L +N L
Sbjct: 104 CKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLL 163
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
SLP L L L+ L L N+ + LP + L L L+L N+L LP EL L+ L
Sbjct: 164 KSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
Query: 125 TLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPT 184
L + N L +LP + L LL L N LR LP + +L++L + + NRL +
Sbjct: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 185 VLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
+ L + + N + P SL L+ L + D N P
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/92 (36%), Positives = 50/92 (54%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDL 113
L +L L++N L +LP LG+L L L +D N+ +ALP + L +L L +N+L L
Sbjct: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL 350
Query: 114 PSELSLLQNLRTLWIEANCLTQLPDVVCELSL 145
P EL+ L L + N L LP + L+L
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHLNL 382
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 92.4 bits (228), Expect = 4e-19
Identities = 62/197 (31%), Positives = 103/197 (52%), Gaps = 1/197 (0%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+DLS + P + +L +LYL N L SLP E+G L NL LAL N+ +LP
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ LK+L +L L +NKL ++PS + L +L TL++ N +T + + LS L L
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Query: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLS 212
N ++ LP ++ L L T+ ++ N+L P + + + +D+ N + P ++ +LS
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
Query: 213 SLKLVIYDHNPCRNAPK 229
SL + +N P+
Sbjct: 285 SLSRLGLRYNRLSAIPR 301
Score = 81.3 bits (199), Expect = 9e-16
Identities = 53/156 (33%), Positives = 79/156 (50%), Gaps = 1/156 (0%)
Query: 75 QNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLT 134
+N L L + LP + L QL LYL +NKL LP+E+ L NL TL + N LT
Sbjct: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
Query: 135 QLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEV 194
LPD + L L+ L N LR +P + RL L T++L NR+T + ++ L +
Sbjct: 160 SLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSM 219
Query: 195 IDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAPK 229
+ + N I+ P+ + L +L + HN + PK
Sbjct: 220 LSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPK 255
Score = 79.7 bits (195), Expect = 3e-15
Identities = 53/174 (30%), Positives = 92/174 (52%), Gaps = 1/174 (0%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+++ +QL PL ++ +V+L L+ N L +P ++ L +L++L L N K LP
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHG 443
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ L++L L L NKL LP+E++ L++L+ L + N LT LP + L+ L L G
Sbjct: 444 LGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGE 503
Query: 154 NALRLLPGQLRRLQELRTIWLSGN-RLTDFPTVLLHMPFLEVIDVDWNSIRYFP 206
N L LP ++ L+ L ++L+ N L P L L ++ ++ + + P
Sbjct: 504 NLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Score = 77.0 bits (188), Expect = 2e-14
Identities = 65/209 (31%), Positives = 91/209 (43%), Gaps = 28/209 (13%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
L ++L+ P V L+ L LS+N L SLP L L+ L++L L N + +P VV
Sbjct: 130 LYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVY 189
Query: 96 TLKQLCILYLG-----------------------NNKLCDLPSELSLLQNLRTLWIEANC 132
L L LYL NK+ LP+E+ L NL TL + N
Sbjct: 190 RLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ 249
Query: 133 LTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFL 192
L LP + + + L N L LP + L L + L NRL+ P L L
Sbjct: 250 LEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSAL 309
Query: 193 EVIDVDWNSIRYFP-----SLAHLSSLKL 216
E ++++ N+I P SL L+SL L
Sbjct: 310 EELNLENNNISTLPESLLSSLVKLNSLTL 338
Score = 73.6 bits (179), Expect = 2e-13
Identities = 54/200 (27%), Positives = 90/200 (45%), Gaps = 3/200 (1%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
+M+DL ++LR P V L LYL N + ++ ++ L L +L++ N K LP
Sbjct: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
Query: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA 151
+ L L L + +N+L LP E+ + L ++ N L LPD + LS L L
Sbjct: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
Query: 152 GSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLL-HMPFLEVIDVDWNSIRYFP--SL 208
N L +P L + L + L N ++ P LL + L + + N + +P
Sbjct: 292 RYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGP 351
Query: 209 AHLSSLKLVIYDHNPCRNAP 228
+ S++ + +HN P
Sbjct: 352 SQFSTIYSLNMEHNRINKIP 371
Score = 73.2 bits (178), Expect = 2e-13
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 3/198 (1%)
Query: 34 VDLSGSQLRRFPLHVCS-FRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
+++ +++ + P + S + L KL + DN L SLP + G ++ L L N +P+
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Query: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAG 152
V L L +L L NN L LP L L+ LR L +E N L LP+ + L L+ L
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLT 479
Query: 153 SNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWN-SIRYFP-SLAH 210
+N L LP + L L + L N LT P + + LE + ++ N ++ P LA
Sbjct: 480 NNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELAL 539
Query: 211 LSSLKLVIYDHNPCRNAP 228
S L ++ ++ P + P
Sbjct: 540 CSKLSIMSIENCPLSHLP 557
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/195 (26%), Positives = 87/195 (44%), Gaps = 1/195 (0%)
Query: 46 LHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYL 105
L+ C ++L LS ++ LP + +L L L L N ++LP V L L L L
Sbjct: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153
Query: 106 GNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRR 165
N L LP L L+ LR L + N L ++P VV L L TL+ N + + ++
Sbjct: 154 SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213
Query: 166 LQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPC 224
L +L + + N++ P + + L +DV N + + P + + + + + HN
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Query: 225 RNAPKVAKGVRRVGR 239
+ P + + R
Sbjct: 274 LDLPDTIGNLSSLSR 288
Score = 59.7 bits (143), Expect = 3e-09
Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 2/165 (1%)
Query: 21 VVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQIL 80
V +D++ + M+ + +++++ P + L+ L ++ N L LP E+G + L
Sbjct: 207 VEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNL 266
Query: 81 ALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPD-V 139
L N LP + L L L L N+L +P L+ L L +E N ++ LP+ +
Sbjct: 267 DLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL 326
Query: 140 VCELSLLKTLHAGSNALRLLP-GQLRRLQELRTIWLSGNRLTDFP 183
+ L L +L N +L P G + + ++ + NR+ P
Sbjct: 327 LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIP 371
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 92.0 bits (227), Expect = 5e-19
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 30/236 (12%)
Query: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
+V+ S + + + P L +LYL+D L LP G+L LQIL L N K LP+
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK 178
Query: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAG 152
+ L QL L LG+N+ ++P L L L+ W++AN LT +P + L L L
Sbjct: 179 TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVS 238
Query: 153 SNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP------ 206
N + ++ + + L+ + LS N L P + + + + +D N + Y P
Sbjct: 239 KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
Query: 207 ------------------SLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEET 244
S+ L++L+ DHN + P +G W T
Sbjct: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP------EIGSWKNIT 348
Score = 84.3 bits (207), Expect = 1e-16
Identities = 59/199 (29%), Positives = 92/199 (46%), Gaps = 2/199 (1%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
L +Q+ P + + + L KL L DN L +LP + L NL+ L + N + P+ +
Sbjct: 53 LDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIK 112
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
K L I+ N + LP S L NL L++ L LP L+ L+ L N
Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ 172
Query: 156 LRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLK 215
L++LP + RL +L + L N T+ P VL + L+ +D N + + P + SLK
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF--IGSLK 230
Query: 216 LVIYDHNPCRNAPKVAKGV 234
+ Y N V +G+
Sbjct: 231 QLTYLDVSKNNIEMVEEGI 249
Score = 80.5 bits (197), Expect = 1e-15
Identities = 44/143 (30%), Positives = 76/143 (53%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
LS + L++ P + S + + L + +N L LP +G L +++ L FN +ALP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
L L +N L LP E+ +N+ L++ +N L LP+ + ++ LK ++ N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 156 LRLLPGQLRRLQELRTIWLSGNR 178
L+ LP +LQ+L +WLS N+
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 77.8 bits (190), Expect = 1e-14
Identities = 60/237 (25%), Positives = 103/237 (43%), Gaps = 15/237 (6%)
Query: 7 ALVAFIPAD--RCQNYVVRDLREMPLDKM------------VDLSGSQLRRFPLHVCSFR 52
A + F+PA+ R + +LRE L + +DL ++ P +
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLS 207
Query: 53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
L + ++ N L +P +G L+ L L + NN + + + + T + L L L +N L
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 113 LPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTI 172
LP + L+N+ TL I+ N L LPD + L ++ L N + LP + +L LRT
Sbjct: 268 LPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 173 WLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
N L P + + V+ + N + P + + LK++ N +N P
Sbjct: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 58.9 bits (141), Expect = 5e-09
Identities = 28/98 (28%), Positives = 52/98 (53%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+D S +++ P + L N+L LPPE+G +N+ +L L N + LP+
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEAN 131
+ +++L ++ L +N+L +LP + LQ L +W+ N
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 30.0 bits (66), Expect = 2.3
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
L ++L P + ++L + LSDN L +LP +LQ L + L N K L
Sbjct: 352 LHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 92.0 bits (227), Expect = 5e-19
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 30/236 (12%)
Query: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
+V+ S + + + P L +LYL+D L LP G+L LQIL L N K LP+
Sbjct: 119 IVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK 178
Query: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAG 152
+ L QL L LG+N+ ++P L L L+ W++AN LT +P + L L L
Sbjct: 179 TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVS 238
Query: 153 SNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP------ 206
N + ++ + + L+ + LS N L P + + + + +D N + Y P
Sbjct: 239 KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
Query: 207 ------------------SLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEET 244
S+ L++L+ DHN + P +G W T
Sbjct: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP------EIGSWKNIT 348
Score = 84.3 bits (207), Expect = 1e-16
Identities = 59/199 (29%), Positives = 92/199 (46%), Gaps = 2/199 (1%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
L +Q+ P + + + L KL L DN L +LP + L NL+ L + N + P+ +
Sbjct: 53 LDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIK 112
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
K L I+ N + LP S L NL L++ L LP L+ L+ L N
Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ 172
Query: 156 LRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLK 215
L++LP + RL +L + L N T+ P VL + L+ +D N + + P + SLK
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF--IGSLK 230
Query: 216 LVIYDHNPCRNAPKVAKGV 234
+ Y N V +G+
Sbjct: 231 QLTYLDVSKNNIEMVEEGI 249
Score = 80.5 bits (197), Expect = 1e-15
Identities = 44/143 (30%), Positives = 76/143 (53%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
LS + L++ P + S + + L + +N L LP +G L +++ L FN +ALP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
L L +N L LP E+ +N+ L++ +N L LP+ + ++ LK ++ N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 156 LRLLPGQLRRLQELRTIWLSGNR 178
L+ LP +LQ+L +WLS N+
Sbjct: 380 LKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 77.8 bits (190), Expect = 1e-14
Identities = 60/237 (25%), Positives = 103/237 (43%), Gaps = 15/237 (6%)
Query: 7 ALVAFIPAD--RCQNYVVRDLREMPLDKM------------VDLSGSQLRRFPLHVCSFR 52
A + F+PA+ R + +LRE L + +DL ++ P +
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLS 207
Query: 53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
L + ++ N L +P +G L+ L L + NN + + + + T + L L L +N L
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 113 LPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTI 172
LP + L+N+ TL I+ N L LPD + L ++ L N + LP + +L LRT
Sbjct: 268 LPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 173 WLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
N L P + + V+ + N + P + + LK++ N +N P
Sbjct: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 58.9 bits (141), Expect = 5e-09
Identities = 28/98 (28%), Positives = 52/98 (53%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+D S +++ P + L N+L LPPE+G +N+ +L L N + LP+
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEAN 131
+ +++L ++ L +N+L +LP + LQ L +W+ N
Sbjct: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
Score = 30.0 bits (66), Expect = 2.3
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
L ++L P + ++L + LSDN L +LP +LQ L + L N K L
Sbjct: 352 LHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 91.7 bits (226), Expect = 6e-19
Identities = 56/162 (34%), Positives = 83/162 (51%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDL 113
L L + DN L SLP + +L+NLQ L + N K LP+ + L+ L LYL +N+L +
Sbjct: 107 LTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCI 166
Query: 114 PSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIW 173
L NL L + N LT +P LS L L+ SN L+ LP ++ R++ L+ +
Sbjct: 167 SEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLD 226
Query: 174 LSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLK 215
+ N L P L M LE++ + N +R+ P S LK
Sbjct: 227 CNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLK 268
Score = 85.5 bits (210), Expect = 5e-17
Identities = 64/210 (30%), Positives = 101/210 (48%), Gaps = 9/210 (4%)
Query: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
DLR +P ++D+ +QL P + L KL +S N L LP E+ L+NL+ L L
Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQ 159
Query: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCEL 143
N + + L L L L NN L +P+ S L +L L + +N L LP + +
Sbjct: 160 HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM 219
Query: 144 SLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNR---LTDFPTVLLHMPFLEVIDVDWN 200
LK L SN L +P +L ++ L ++L N+ L +FP+ L L+ + V N
Sbjct: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSL----LKELHVGEN 275
Query: 201 SIRYFPS--LAHLSSLKLVIYDHNPCRNAP 228
I + L HL+S+ ++ N ++ P
Sbjct: 276 QIEMLEAEHLKHLNSILVLDLRDNKLKSVP 305
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 1/178 (0%)
Query: 53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCD 112
+L KL +S+N L SL +L L L +L + N +LP + L+ L L + +NKL
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 113 LPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTI 172
LP E++ L+NL+ L+++ N LT + + +LS L+ L +N L +P L L +
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 173 WLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYF-PSLAHLSSLKLVIYDHNPCRNAPK 229
LS N L P + M L+ +D + N + P LA + SL+L+ N R P+
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE 260
Score = 77.8 bits (190), Expect = 1e-14
Identities = 49/136 (36%), Positives = 78/136 (57%), Gaps = 3/136 (2%)
Query: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
+L+EM D VDLS ++L L +C ++L L L +N LNSLP E+ L LQ + L
Sbjct: 446 ELKEMVSD--VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLS 503
Query: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDL-PSELSLLQNLRTLWIEANCLTQLPDVVCE 142
FN FK LP+V+ + L + + NN++ + P ++ +++NL TL ++ N L Q+P +
Sbjct: 504 FNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN 563
Query: 143 LSLLKTLHAGSNALRL 158
L+TL N R+
Sbjct: 564 CVNLRTLLLDGNPFRV 579
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 5/177 (2%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRE---LVKLYLSDNHLNSLPPELGQLQNL-QILALDFNNF 87
K++D S Q P V + + + S N L +P + +L+ + + L FN
Sbjct: 402 KILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKL 461
Query: 88 KALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLK 147
+ +C L++L L L NN L LP E+ L L+T+ + N LP+V+ + L+
Sbjct: 462 SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLE 521
Query: 148 TLHAGSNALRLL-PGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
T+ +N + + P +++ ++ L T+ L N L P L + L + +D N R
Sbjct: 522 TILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFR 578
Score = 52.8 bits (125), Expect = 3e-07
Identities = 41/149 (27%), Positives = 71/149 (47%), Gaps = 24/149 (16%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
++LS ++L+ P + + L L + N L ++PPEL +++L++L L N + LP+
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
Query: 94 V-CTL----------------------KQLCILYLGNNKLCDLPSELSLLQNLRTLWIEA 130
C+L + +L L +NKL +P E+ LL++L L +
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321
Query: 131 NCLTQLPDVVCELSLLKTLHAGSNALRLL 159
N ++ LP + L LK L N LR +
Sbjct: 322 NDISSLPYSLGNLH-LKFLALEGNPLRTI 349
Score = 45.8 bits (107), Expect = 4e-05
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 28/211 (13%)
Query: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
++DL ++L+ P + R L +L LS+N ++SLP LG L +L+ LAL+ N + + +
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRR 351
Query: 93 VVCTLKQLCILYLGNNKLCD---------------LPSE----LSLLQNLRTLWIEANCL 133
+ + +L +K+ D LPSE + + L+ L
Sbjct: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQA 411
Query: 134 TQLPDVVCEL---SLLKTLHAGSNALRLLPGQLRRLQEL-RTIWLSGNRLTDFPTVLLHM 189
T +PD V + +++ +++ N L +P ++ L+E+ + LS N+L+ L +
Sbjct: 412 TLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL 471
Query: 190 PFLEVIDVDWNSIRYFP----SLAHLSSLKL 216
L +D+ N + P SL L ++ L
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINL 502
Score = 32.0 bits (71), Expect = 0.61
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 1/71 (1%)
Query: 47 HVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLG 106
H+ ++ L L DN L S+P E+ L++L+ L L N+ +LP + L L L L
Sbjct: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALE 342
Query: 107 NNKLCDLPSEL 117
N L + E+
Sbjct: 343 GNPLRTIRREI 353
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 87.8 bits (216), Expect = 9e-18
Identities = 48/160 (30%), Positives = 91/160 (56%), Gaps = 2/160 (1%)
Query: 21 VVRDLREMPLDKMVDLSGSQLRRFPLHVCS-FRELVKLYLSDNHLNSLPPELGQLQNLQI 79
V +++ + K + LSG+++ RF C + L+ L L++NHL LP E+ +L++L
Sbjct: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
Query: 80 LALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDV 139
+++++N ++P+ +C L+ L L L N+L +P E+ L+ L+ L + N + LP+
Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
Query: 140 VCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRL 179
+C+L L+ L N +++ P + L +LR + GN L
Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPL 233
Score = 81.3 bits (199), Expect = 9e-16
Identities = 55/184 (29%), Positives = 92/184 (50%), Gaps = 1/184 (0%)
Query: 25 LREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDF 84
L ++P K + L + + + +C+ +L L L +N L +P E+ L +L+ L L
Sbjct: 33 LGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSG 92
Query: 85 NNFKALPQVVCT-LKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCEL 143
N C L+ L +L L NN L LP E+S L++L + I N L +P +C L
Sbjct: 93 NRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFL 152
Query: 144 SLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIR 203
L L N L +P +++ L++L+ + L+ N + P L + L ++D+ N I+
Sbjct: 153 ENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQ 212
Query: 204 YFPS 207
FPS
Sbjct: 213 IFPS 216
Score = 68.2 bits (165), Expect = 8e-12
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 2/166 (1%)
Query: 59 LSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELS 118
L+ + +P LG+L L+ L L N + +C L QL L LGNN L ++P E+
Sbjct: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMK 80
Query: 119 LLQNLRTLWIEANCLTQLPDVVCE-LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGN 177
L +L+ L + N + + C+ L L L+ +N L LP ++ RL+ L + ++ N
Sbjct: 81 YLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYN 140
Query: 178 RLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHN 222
+L P L + L + +++N + P + L L+ ++ N
Sbjct: 141 QLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN 186
Score = 60.8 bits (146), Expect = 1e-09
Identities = 38/134 (28%), Positives = 72/134 (53%), Gaps = 2/134 (1%)
Query: 98 KQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALR 157
K I+ L K+ +PS L L L+TL ++ N + ++ +C L+ L TL+ G+N L
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 158 LLPGQLRRLQELRTIWLSGNRLTDF-PTVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLK 215
+P +++ L L+ + LSGNR+ F P + L +++++ N + P ++ L SL
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 216 LVIYDHNPCRNAPK 229
+ ++N + P+
Sbjct: 134 YMSINYNQLASIPR 147
Score = 28.9 bits (63), Expect = 5.2
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 1/77 (1%)
Query: 157 RLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI-RYFPSLAHLSSLK 215
RLL L + + I L+G ++T P+ L +P L+ + + N I + P L +L+ L
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
Query: 216 LVIYDHNPCRNAPKVAK 232
+ +N P+ K
Sbjct: 64 TLNLGNNLLEEVPEEMK 80
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 87.8 bits (216), Expect = 9e-18
Identities = 57/163 (34%), Positives = 88/163 (53%), Gaps = 4/163 (2%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLY---LSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
+DL + L+ + SF+ L +L L NH+ +P ++G L NL+ L L+ N + +
Sbjct: 619 IDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI 677
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P + ++L L L +N L LP+++ LLQNL+ L I AN + LP + + L+ LH
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALH 737
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLE 193
G+N L+ LP ++ L L I L GNRL P L P L+
Sbjct: 738 LGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 62.4 bits (150), Expect = 4e-10
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 6/169 (3%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCT--LKQLCILYLGNNKLC 111
L +L L L +P + L NLQ + L NN K + +++ L +L L L N +
Sbjct: 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652
Query: 112 DLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRT 171
+P ++ L NL L++ N + ++P + L+ L N L LP + LQ L+
Sbjct: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 172 IWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS----LAHLSSLKL 216
+ ++ NR+ P L L + + N ++ PS L +L+ ++L
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Score = 38.9 bits (89), Expect = 0.005
Identities = 47/181 (25%), Positives = 86/181 (47%), Gaps = 21/181 (11%)
Query: 56 KLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKL-CDLP 114
KL L L+ +P + L L++L L+ +P + L L L+L + + P
Sbjct: 427 KLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAP 486
Query: 115 SELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH------AGSNALRLLPGQLRRLQE 168
+ L +NLR L I+ + ++P + L L+ LH A +N ++ G LR L+
Sbjct: 487 ALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG-LRELKR 545
Query: 169 LRTIWLSGNRLTDFPTVL----LHMPFLEVID-----VDWNSIRYFPSLAHLSSLKLVIY 219
L+ + L N L+ P V+ +H+ L + + + NS++ +A+L+ L+L+
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK---KMANLTELELIRC 601
Query: 220 D 220
D
Sbjct: 602 D 602
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 87.8 bits (216), Expect = 9e-18
Identities = 57/163 (34%), Positives = 88/163 (53%), Gaps = 4/163 (2%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLY---LSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
+DL + L+ + SF+ L +L L NH+ +P ++G L NL+ L L+ N + +
Sbjct: 619 IDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI 677
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P + ++L L L +N L LP+++ LLQNL+ L I AN + LP + + L+ LH
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALH 737
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLE 193
G+N L+ LP ++ L L I L GNRL P L P L+
Sbjct: 738 LGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 62.4 bits (150), Expect = 4e-10
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 6/169 (3%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCT--LKQLCILYLGNNKLC 111
L +L L L +P + L NLQ + L NN K + +++ L +L L L N +
Sbjct: 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652
Query: 112 DLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRT 171
+P ++ L NL L++ N + ++P + L+ L N L LP + LQ L+
Sbjct: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 172 IWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS----LAHLSSLKL 216
+ ++ NR+ P L L + + N ++ PS L +L+ ++L
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Score = 38.9 bits (89), Expect = 0.005
Identities = 47/181 (25%), Positives = 86/181 (47%), Gaps = 21/181 (11%)
Query: 56 KLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKL-CDLP 114
KL L L+ +P + L L++L L+ +P + L L L+L + + P
Sbjct: 427 KLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAP 486
Query: 115 SELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH------AGSNALRLLPGQLRRLQE 168
+ L +NLR L I+ + ++P + L L+ LH A +N ++ G LR L+
Sbjct: 487 ALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG-LRELKR 545
Query: 169 LRTIWLSGNRLTDFPTVL----LHMPFLEVID-----VDWNSIRYFPSLAHLSSLKLVIY 219
L+ + L N L+ P V+ +H+ L + + + NS++ +A+L+ L+L+
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK---KMANLTELELIRC 601
Query: 220 D 220
D
Sbjct: 602 D 602
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 87.8 bits (216), Expect = 9e-18
Identities = 57/163 (34%), Positives = 88/163 (53%), Gaps = 4/163 (2%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLY---LSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
+DL + L+ + SF+ L +L L NH+ +P ++G L NL+ L L+ N + +
Sbjct: 619 IDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI 677
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P + ++L L L +N L LP+++ LLQNL+ L I AN + LP + + L+ LH
Sbjct: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALH 737
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLE 193
G+N L+ LP ++ L L I L GNRL P L P L+
Sbjct: 738 LGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 62.4 bits (150), Expect = 4e-10
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 6/169 (3%)
Query: 54 LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCT--LKQLCILYLGNNKLC 111
L +L L L +P + L NLQ + L NN K + +++ L +L L L N +
Sbjct: 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652
Query: 112 DLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRT 171
+P ++ L NL L++ N + ++P + L+ L N L LP + LQ L+
Sbjct: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 172 IWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS----LAHLSSLKL 216
+ ++ NR+ P L L + + N ++ PS L +L+ ++L
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
Score = 38.9 bits (89), Expect = 0.005
Identities = 47/181 (25%), Positives = 86/181 (47%), Gaps = 21/181 (11%)
Query: 56 KLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKL-CDLP 114
KL L L+ +P + L L++L L+ +P + L L L+L + + P
Sbjct: 427 KLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAP 486
Query: 115 SELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH------AGSNALRLLPGQLRRLQE 168
+ L +NLR L I+ + ++P + L L+ LH A +N ++ G LR L+
Sbjct: 487 ALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG-LRELKR 545
Query: 169 LRTIWLSGNRLTDFPTVL----LHMPFLEVID-----VDWNSIRYFPSLAHLSSLKLVIY 219
L+ + L N L+ P V+ +H+ L + + + NS++ +A+L+ L+L+
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK---KMANLTELELIRC 601
Query: 220 D 220
D
Sbjct: 602 D 602
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 84.3 bits (207), Expect = 1e-16
Identities = 68/209 (32%), Positives = 99/209 (47%), Gaps = 9/209 (4%)
Query: 13 PADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELG 72
P ++Y + D+ + DLS ++ P C L L L N L L P LG
Sbjct: 58 PRGAARSYDLSDITQ------ADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALG 111
Query: 73 QLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANC 132
L L L L N LP +C L L +L + NNKL LP ++ L +LR L + +N
Sbjct: 112 NLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNE 170
Query: 133 LTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFL 192
L LP +C LS L+ L+ N L LP +L L +R + S NR++ P + L
Sbjct: 171 LQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHL 229
Query: 193 EVIDVDWNSIRYFPSLAHLSSLKLVIYDH 221
+VI +D N ++ P+ L KL I+ +
Sbjct: 230 QVILLDSNPLQSPPAQVCLKG-KLHIFKY 257
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 83.2 bits (204), Expect = 2e-16
Identities = 64/195 (32%), Positives = 104/195 (53%), Gaps = 3/195 (1%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
+S + ++ P ++ F+ + L L N ++ LP E+G L+NL+ L + FN K++P +
Sbjct: 128 ISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
Query: 96 TLKQLCILYL-GNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSN 154
+ L L GN +L +LP ELS L+ + + I AN + +P V +S L+ L SN
Sbjct: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
Query: 155 ALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSS- 213
L LP + RL+EL++ L N+LT P +L++ L ++ V + + P+ SS
Sbjct: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSST 307
Query: 214 -LKLVIYDHNPCRNA 227
LK V NP NA
Sbjct: 308 PLKFVSLMDNPIDNA 322
Score = 79.3 bits (194), Expect = 3e-15
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 1/156 (0%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFN-NFKAL 90
+++DL +Q+ P + + L +L + N+L S+PPELG +NL+ L N L
Sbjct: 147 RILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMEL 206
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P + LKQ+ + + NK +P + + NL+ L I +N LT LP + L L++
Sbjct: 207 PFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVL 186
N L LP + L++L + +SG+ L + PT L
Sbjct: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 54.3 bits (129), Expect = 1e-07
Identities = 41/167 (24%), Positives = 78/167 (46%), Gaps = 2/167 (1%)
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
+SLP + G+ + + L ++ LP + L Y+ N + +P+ + L Q +R
Sbjct: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
Query: 125 TLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGN-RLTDFP 183
L + N ++ LP + L LK L+ G N L+ +P +L + L + SGN L + P
Sbjct: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
Query: 184 TVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAPK 229
L ++ + +D+ N P + +S+L+ + N + P+
Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQ 254
Score = 48.9 bits (115), Expect = 5e-06
Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 24 DLREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQN 76
+L E+P + VD+S ++ P+ V L L +S N+L LP ++ +L+
Sbjct: 202 ELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEE 261
Query: 77 LQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSEL 117
LQ L N LP + LK+L +L + + L +LP+ L
Sbjct: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 83.2 bits (204), Expect = 2e-16
Identities = 64/195 (32%), Positives = 104/195 (53%), Gaps = 3/195 (1%)
Query: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
+S + ++ P ++ F+ + L L N ++ LP E+G L+NL+ L + FN K++P +
Sbjct: 128 ISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
Query: 96 TLKQLCILYL-GNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSN 154
+ L L GN +L +LP ELS L+ + + I AN + +P V +S L+ L SN
Sbjct: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
Query: 155 ALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSS- 213
L LP + RL+EL++ L N+LT P +L++ L ++ V + + P+ SS
Sbjct: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSST 307
Query: 214 -LKLVIYDHNPCRNA 227
LK V NP NA
Sbjct: 308 PLKFVSLMDNPIDNA 322
Score = 79.3 bits (194), Expect = 3e-15
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 1/156 (0%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFN-NFKAL 90
+++DL +Q+ P + + L +L + N+L S+PPELG +NL+ L N L
Sbjct: 147 RILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMEL 206
Query: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
P + LKQ+ + + NK +P + + NL+ L I +N LT LP + L L++
Sbjct: 207 PFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFL 266
Query: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVL 186
N L LP + L++L + +SG+ L + PT L
Sbjct: 267 LYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 54.3 bits (129), Expect = 1e-07
Identities = 41/167 (24%), Positives = 78/167 (46%), Gaps = 2/167 (1%)
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
+SLP + G+ + + L ++ LP + L Y+ N + +P+ + L Q +R
Sbjct: 88 SSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMR 147
Query: 125 TLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGN-RLTDFP 183
L + N ++ LP + L LK L+ G N L+ +P +L + L + SGN L + P
Sbjct: 148 ILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
Query: 184 TVLLHMPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAPK 229
L ++ + +D+ N P + +S+L+ + N + P+
Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQ 254
Score = 48.9 bits (115), Expect = 5e-06
Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 24 DLREMPLD-------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQN 76
+L E+P + VD+S ++ P+ V L L +S N+L LP ++ +L+
Sbjct: 202 ELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEE 261
Query: 77 LQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSEL 117
LQ L N LP + LK+L +L + + L +LP+ L
Sbjct: 262 LQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 81.6 bits (200), Expect = 7e-16
Identities = 60/209 (28%), Positives = 97/209 (46%), Gaps = 5/209 (2%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCS--FRELVKLYLSDNHLNSLPPELGQLQNLQIL 80
R L E + ++ LSG +LR FP + + + LS N L+ +P E +L+ L
Sbjct: 51 RALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENL 110
Query: 81 ALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVV 140
L N + +P+ + L+ L L + N+L LP L L L+ L N L LP+ +
Sbjct: 111 NLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEI 169
Query: 141 CELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWN 200
L L L N ++ +P Q+ L+ LR + + N L P L +P + +D N
Sbjct: 170 GHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCN 228
Query: 201 SIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
I P +L L+ + D+NP ++ P
Sbjct: 229 KITTIPVCYRNLRHLQTITLDNNPLQSPP 257
Score = 80.1 bits (196), Expect = 2e-15
Identities = 61/205 (29%), Positives = 97/205 (47%), Gaps = 6/205 (2%)
Query: 35 DLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVV 94
DLS ++L P+ C F L L L N + +P + LQ L L + N LP +
Sbjct: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
Query: 95 CTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSN 154
C L L +L NNKL LP E+ L++L L + N + +P + L L+ L+ N
Sbjct: 148 CNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
Query: 155 ALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSL 214
L LP +L L +R + S N++T P ++ L+ I +D N ++ P+ +
Sbjct: 207 HLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKG- 264
Query: 215 KLVIYDH---NPCRNAPKVAKGVRR 236
K+ I+ + C+ AP + RR
Sbjct: 265 KVHIFKYLNIQACKIAPDLPDYDRR 289
Score = 65.5 bits (158), Expect = 5e-11
Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Query: 17 CQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQN 76
C Y+ + + +++S +QL P+H+C+ L L S+N L SLP E+G L++
Sbjct: 116 CIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRH 174
Query: 77 LQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQL 136
L L + N + +P + L+ L L + N L LP EL+ L +R L N +T +
Sbjct: 175 LMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTI 233
Query: 137 PDVVCELSLLKTLHAGSNALRLLPGQL 163
P L L+T+ +N L+ P Q+
Sbjct: 234 PVCYRNLRHLQTITLDNNPLQSPPAQI 260
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 80.5 bits (197), Expect = 1e-15
Identities = 59/161 (36%), Positives = 76/161 (47%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+DLS + L P V R L L LS N L+ LP LG L L L + N + LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ L L L L N L LP E+ L +L L + +N L LP + L L+ L S
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEV 194
N L +P L RL L + L N+L D P LL PF+ +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRL 290
Score = 79.3 bits (194), Expect = 3e-15
Identities = 55/166 (33%), Positives = 76/166 (45%)
Query: 41 LRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQL 100
L P + L L LS N L +LP + Q++ L L L N LP+ + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 101 CILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLP 160
L + +N+L LP L L L+ L + N L LP + L L L+ SN L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 161 GQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP 206
L L+ LR + L N L P L +P L +D+ N +R P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/166 (32%), Positives = 77/166 (46%), Gaps = 1/166 (0%)
Query: 64 LNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNL 123
L +LP L L +L L L FN+ + LP V ++ L L L +N L +LP L L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 124 RTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFP 183
L + N L LP + LS L+ L N L LP ++ L L + L+ NRL P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 184 TVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
L + L ++ + N + P+ LA L L + N R+ P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 61.6 bits (148), Expect = 7e-10
Identities = 41/133 (30%), Positives = 71/133 (53%)
Query: 5 IRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
+R L A + + C + + L +P + ++ ++L+ P + + L +L LS N L
Sbjct: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
++LPPE+G L +L L L N ++LP + L+ L +L L +N L +P++L+ L L
Sbjct: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
Query: 125 TLWIEANCLTQLP 137
L + N L LP
Sbjct: 267 RLDLRDNQLRDLP 279
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 80.5 bits (197), Expect = 1e-15
Identities = 59/161 (36%), Positives = 76/161 (47%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+DLS + L P V R L L LS N L+ LP LG L L L + N + LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGS 153
+ L L L L N L LP E+ L +L L + +N L LP + L L+ L S
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEV 194
N L +P L RL L + L N+L D P LL PF+ +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRL 290
Score = 79.3 bits (194), Expect = 3e-15
Identities = 55/166 (33%), Positives = 76/166 (45%)
Query: 41 LRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQL 100
L P + L L LS N L +LP + Q++ L L L N LP+ + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 101 CILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLP 160
L + +N+L LP L L L+ L + N L LP + L L L+ SN L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 161 GQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP 206
L L+ LR + L N L P L +P L +D+ N +R P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/166 (32%), Positives = 77/166 (46%), Gaps = 1/166 (0%)
Query: 64 LNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNL 123
L +LP L L +L L L FN+ + LP V ++ L L L +N L +LP L L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 124 RTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFP 183
L + N L LP + LS L+ L N L LP ++ L L + L+ NRL P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 184 TVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
L + L ++ + N + P+ LA L L + N R+ P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 61.6 bits (148), Expect = 7e-10
Identities = 41/133 (30%), Positives = 71/133 (53%)
Query: 5 IRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
+R L A + + C + + L +P + ++ ++L+ P + + L +L LS N L
Sbjct: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 65 NSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLR 124
++LPPE+G L +L L L N ++LP + L+ L +L L +N L +P++L+ L L
Sbjct: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
Query: 125 TLWIEANCLTQLP 137
L + N L LP
Sbjct: 267 RLDLRDNQLRDLP 279
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 79.3 bits (194), Expect = 3e-15
Identities = 67/223 (30%), Positives = 108/223 (48%), Gaps = 14/223 (6%)
Query: 12 IPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPEL 71
+PA R N +L+ K ++LS + L FPL VCS L +L +S N L S+P +
Sbjct: 166 LPAARGLN----ELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAV 221
Query: 72 GQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEAN 131
G + NLQ LD N ++LP + +KQL L L N+ D+P L L + L + N
Sbjct: 222 GVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGN 281
Query: 132 CLTQLP-DVVCELSLLKTLHAGSNALR-LLPGQLRRLQELRTIWLSGNRLTDFPTVLLHM 189
C+ L + ++ +K + N +R L+ ++ LQ + + L N+L D ++ +
Sbjct: 282 CVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNN 341
Query: 190 PFLEVIDVDWNSI------RYFPSLAHLSSLKLVIYDHNPCRN 226
+EV+ + N + YF + SS +LV D P N
Sbjct: 342 --IEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPN 382
Score = 65.9 bits (159), Expect = 4e-11
Identities = 67/273 (24%), Positives = 119/273 (43%), Gaps = 42/273 (15%)
Query: 3 NTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDN 62
N IR L+A D Q+ DLR+ +K+ DL + C +LV L +
Sbjct: 305 NVIRKLIAD-EVDFLQHVTQLDLRD---NKLGDLDAMIFNNIEVLHCERNQLVTLDICGY 360
Query: 63 HLNSLPPELGQLQNLQI---------LALDFNNFKALPQVVCTLKQLCILYLGNNKLCDL 113
L +L +L L + + + N + +P+ VC ++L +L +G+N++C+L
Sbjct: 361 FLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420
Query: 114 PSELSLLQNLRTLWIEANCLTQLPD-----------------------VVCELSLLKTLH 150
P+ L +LR L N L +LP+ ++ + L+ L+
Sbjct: 421 PARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLN 480
Query: 151 AGSNALRLLPGQLRRLQE---LRTIWLSGNRLTDFPTVLL-HMPFLEVIDVDWNSIRYFP 206
A +N L LP + L+ ++L+ N LTD LL P L+++ + +N ++ FP
Sbjct: 481 ASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFP 540
Query: 207 S--LAHLSSLKLVIYDHNPCRNAPKVAKGVRRV 237
+ +A L L+ + N + P RR+
Sbjct: 541 ASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRM 573
Score = 65.1 bits (157), Expect = 6e-11
Identities = 60/213 (28%), Positives = 94/213 (44%), Gaps = 30/213 (14%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
+D+S ++L P VC R+L L + N + LP L +L+ L N LP+
Sbjct: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSL-LQNLRTLWIEANCLTQLP---------DVVCEL 143
+ + +L + +N+L +LP L + +LR L AN L LP ++ EL
Sbjct: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
Query: 144 SL------------------LKTLHAGSNALRLLPG-QLRRLQELRTIWLSGNRLTDFPT 184
L LK LH N L+ P ++ +L+EL I LSGN+L PT
Sbjct: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565
Query: 185 VLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLV 217
+++ + + N I FP + L +K V
Sbjct: 566 TIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCV 598
Score = 31.2 bits (69), Expect = 1.0
Identities = 29/118 (24%), Positives = 57/118 (48%), Gaps = 6/118 (5%)
Query: 15 DRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQL 74
+R Q++ + ++ + +DLSG++L+ P + + R + + N + PE+ QL
Sbjct: 534 NRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVF-PEVMQL 592
Query: 75 QNLQILALDFNNFK--ALPQ-VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIE 129
++ + L N LP+ + L++L + GN +L L LL N+R I+
Sbjct: 593 PEIKCVDLSCNELSEVTLPENLPPKLQELDL--TGNPRLVLDHKTLELLNNIRCFKID 648
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 79.3 bits (194), Expect = 3e-15
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 8/184 (4%)
Query: 54 LVKLYLSDNHLNSLPPELGQ-LQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKL-- 110
L++L L N L SLP LG +LQ+L + N AL + L+ L L NN+L
Sbjct: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
Query: 111 -CDLPSELS---LLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRL 166
LP L+ L ++L+ L + NC ++P + EL L+TL G N L+ +P ++ L
Sbjct: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
Query: 167 QELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYF-PSLAHLSSLKLVIYDHNPCR 225
Q L ++L GN + + P L ++P L + + N I+ P L+ L SL+ + +N
Sbjct: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
Query: 226 NAPK 229
P+
Sbjct: 226 YLPR 229
Score = 79.3 bits (194), Expect = 3e-15
Identities = 54/177 (30%), Positives = 94/177 (53%), Gaps = 6/177 (3%)
Query: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHL---NSLPPELGQ---LQNLQILALDFN 85
+++D+SG+ L + + R L L +N L ++LP L Q ++LQ+L L N
Sbjct: 71 QLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGN 130
Query: 86 NFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSL 145
F+ +P + L+ L L LG N+L +P+E+ LQ+L L++ N + ++P + L
Sbjct: 131 CFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPS 190
Query: 146 LKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
L L N ++ +P QL +L LR++ L N LT P +L++ LE + + N +
Sbjct: 191 LNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/128 (32%), Positives = 62/128 (48%)
Query: 6 RALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLN 65
R+L + C V L E+ + + L G+QL+ P + + + L LYL N +
Sbjct: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
Query: 66 SLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRT 125
+PPELG L +L L L N +++P + L L L L NN L LP E+ L +L
Sbjct: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
Query: 126 LWIEANCL 133
L + N L
Sbjct: 240 LSLRGNPL 247
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 79.0 bits (193), Expect = 4e-15
Identities = 59/207 (28%), Positives = 96/207 (46%), Gaps = 3/207 (1%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
R L E ++ LSG +LR FP + + LS N +P ++ L+ L L
Sbjct: 82 RALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNL 141
Query: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
N K +P+ + L+ L L + N L LP L L L+ L + N L +P+ + +
Sbjct: 142 YHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGK 200
Query: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
L L L N +++LP Q+ +L LR + + N L P L +P ++ +D N +
Sbjct: 201 LKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKV 259
Query: 203 RYFP-SLAHLSSLKLVIYDHNPCRNAP 228
P L L+++I D+NP + P
Sbjct: 260 TEIPVCYRKLHHLQVIILDNNPLQVPP 286
Score = 33.1 bits (74), Expect = 0.27
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
Query: 30 LDKMVDLSGSQLRRFPLHVCSFR----ELVKLYLSDNHLNSLPPELGQLQNLQILALDFN 85
+ K+ L +RR LHV LVKL S N + +P +L +LQ++ LD N
Sbjct: 221 MGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNN 280
Query: 86 NFKALPQVVCTLKQLCILYLGNNKLC 111
+ P +C ++ I N + C
Sbjct: 281 PLQVPPAQICLKGKVHIFKYLNIQAC 306
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 79.0 bits (193), Expect = 4e-15
Identities = 61/210 (29%), Positives = 101/210 (48%), Gaps = 6/210 (2%)
Query: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFREL---VKLYLSDNHLNSLPPELGQLQNLQI 79
R L E ++LS +L+ FP +L V+ LS N L +P EL +L+I
Sbjct: 65 RALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEI 124
Query: 80 LALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDV 139
L L N + +P+ + L+ L L L N+L LP+ L L L+ L N L LP+
Sbjct: 125 LNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEE 183
Query: 140 VCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDW 199
+ +L L L N + LP Q+ +L+ LR + + N L P L+ +P ++ D
Sbjct: 184 IGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVK-FDFSC 242
Query: 200 NSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
N + P + L++++ ++NP ++ P
Sbjct: 243 NKVLVIPICFREMKQLQVLLLENNPLQSPP 272
Score = 56.6 bits (135), Expect = 2e-08
Identities = 46/132 (34%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
++LS +QL P +C L L S+N L SLP E+GQL+ L L + N ALPQ
Sbjct: 148 LNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQ 206
Query: 94 VCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVC--ELSLLKTLHA 151
+ LK L L + N L LP E L +L + + +C L +C E+ L+ L
Sbjct: 207 IGQLKSLRELNVRRNYLKVLPQE---LVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLL 263
Query: 152 GSNALRLLPGQL 163
+N L+ P Q+
Sbjct: 264 ENNPLQSPPAQI 275
Score = 48.9 bits (115), Expect = 5e-06
Identities = 34/114 (29%), Positives = 61/114 (53%), Gaps = 2/114 (1%)
Query: 28 MPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNF 87
+PL K++ S ++L P + ++L++L +S N + +LP ++GQL++L+ L + N
Sbjct: 165 LPL-KVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYL 223
Query: 88 KALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVC 141
K LPQ + L L NK+ +P ++ L+ L +E N L P +C
Sbjct: 224 KVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQIC 276
Score = 30.0 bits (66), Expect = 2.3
Identities = 23/108 (21%), Positives = 47/108 (43%), Gaps = 22/108 (20%)
Query: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPEL---------------------- 71
+D+S +++ P + + L +L + N+L LP EL
Sbjct: 193 LDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICF 252
Query: 72 GQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSL 119
+++ LQ+L L+ N ++ P +CT ++ I + + C + + SL
Sbjct: 253 REMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL 300
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 78.2 bits (191), Expect = 7e-15
Identities = 61/207 (29%), Positives = 99/207 (47%), Gaps = 6/207 (2%)
Query: 21 VVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELG--QLQNLQ 78
V+ L++M ++L +L R P + S L +L L N++ ++ + L+ L
Sbjct: 627 VLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
Query: 79 ILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPD 138
L L N +P + +K L LY NNKL LP + LQ LR L + N ++ +P
Sbjct: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
Query: 139 VVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVD 198
+ L L+ LH N + +LP QL + +LRT+ L N +T P + + L +++
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 199 WNSIRYFPS-LAHLSSLK---LVIYDH 221
N + P+ L LK LV+ DH
Sbjct: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDH 833
Score = 36.2 bits (82), Expect = 0.032
Identities = 44/195 (22%), Positives = 77/195 (39%), Gaps = 33/195 (16%)
Query: 67 LPPELGQLQNLQILALDFNNFKALPQVVCTLKQ-LCILYLGNNKLCDLPSELSLLQNLRT 125
+P ++ Q+ NLQ L L K L+ L L++ + ++P+ + LL+NLR
Sbjct: 505 IPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRE 564
Query: 126 LWIEANCLTQLPDVV-----CELSLLKTLHAGSNALR----------------------- 157
L++ N ++ ++ EL LK LH SN +
Sbjct: 565 LYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTK 624
Query: 158 -LLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP---SLAHLSS 213
L+ L+++ + + L L P + + L+ +D+ N+IR S HL
Sbjct: 625 LLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKR 684
Query: 214 LKLVIYDHNPCRNAP 228
L + HN P
Sbjct: 685 LTCLKLWHNKIVTIP 699
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,391,458
Number of Sequences: 37866
Number of extensions: 509567
Number of successful extensions: 2430
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 1324
Number of HSP's gapped (non-prelim): 690
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.