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Search of human proteins with 62988346
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62988346 glutamate receptor, ionotropic,
N-methyl-D-aspartate 3B [Homo sapiens]
(1043 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 2111 0.0
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 951 0.0
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 288 2e-77
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 278 3e-74
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 258 2e-68
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 250 6e-66
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 250 6e-66
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 250 6e-66
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 243 5e-64
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 242 2e-63
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 241 3e-63
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 165 2e-40
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 165 2e-40
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 163 9e-40
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 159 1e-38
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 158 3e-38
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 157 4e-38
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 157 4e-38
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 157 4e-38
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 155 1e-37
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 155 2e-37
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 154 4e-37
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 154 5e-37
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 153 7e-37
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 153 7e-37
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 150 6e-36
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 147 7e-35
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 144 4e-34
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 140 5e-33
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 40 0.015
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 2111 bits (5469), Expect = 0.0
Identities = 1043/1043 (100%), Positives = 1043/1043 (100%)
Query: 1 MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARA 60
MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARA
Sbjct: 1 MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARA 60
Query: 61 ALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLA 120
ALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLA
Sbjct: 61 ALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLA 120
Query: 121 AATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCR 180
AATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCR
Sbjct: 121 AATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCR 180
Query: 181 TQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGC 240
TQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGC
Sbjct: 181 TQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGC 240
Query: 241 DIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
DIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV
Sbjct: 241 DIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
Query: 301 ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSS 360
ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSS
Sbjct: 301 ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSS 360
Query: 361 QVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV 420
QVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV
Sbjct: 361 QVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV 420
Query: 421 TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYC 480
TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYC
Sbjct: 421 TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYC 480
Query: 481 IDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ 540
IDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ
Sbjct: 481 IDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ 540
Query: 541 VVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSP 600
VVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSP
Sbjct: 541 VVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSP 600
Query: 601 YGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSY 660
YGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSY
Sbjct: 601 YGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSY 660
Query: 661 TANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRH 720
TANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRH
Sbjct: 661 TANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRH 720
Query: 721 SAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQN 780
SAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQN
Sbjct: 721 SAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQN 780
Query: 781 SPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL 840
SPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL
Sbjct: 781 SPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL 840
Query: 841 GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEP 900
GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEP
Sbjct: 841 GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEP 900
Query: 901 SGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGP 960
SGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGP
Sbjct: 901 SGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGP 960
Query: 961 VWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPR 1020
VWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPR
Sbjct: 961 VWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPR 1020
Query: 1021 RLLQARAAPAEAPPHSGRPGSQE 1043
RLLQARAAPAEAPPHSGRPGSQE
Sbjct: 1021 RLLQARAAPAEAPPHSGRPGSQE 1043
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
[Homo sapiens]
Length = 1115
Score = 951 bits (2459), Expect = 0.0
Identities = 517/1102 (46%), Positives = 693/1102 (62%), Gaps = 135/1102 (12%)
Query: 16 GPGSAGGHPQPCGVLARLGGSVR------------------------------------- 38
G S+ HPQPC +L R+G +VR
Sbjct: 27 GVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTR 86
Query: 39 -----------LGALL-------PRAPLARARARAALARAALA----------PRLPHNL 70
LG+ L R P ARA A R AL LP+NL
Sbjct: 87 RSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNL 146
Query: 71 SLELVVA-----------------APPARDPASLTRGLCQALVPPGVAALLAFPEARPEL 113
SLE+V+A +P + DP S + +C +V GV+ALLAFP+++ E+
Sbjct: 147 SLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEM 206
Query: 114 LQLHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWED 173
++L ++ PV+S++R E P + NP HLQL + L + DV V++L + W +
Sbjct: 207 MELDLVSLVLHIPVISIVRHE--FPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYN 264
Query: 174 VGLALCRTQ-DPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPV 232
L LC+ + + L + + +++++ L + L + +
Sbjct: 265 FSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESI--KNST 322
Query: 233 PAAVLLGCDIARARRVLE------AVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVAR 286
P V+ GCD+ RR+ E +PP W+LG + L T GLP GL+A G+ +
Sbjct: 323 PTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQ 382
Query: 287 PPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTS 346
E + D ++LVARA+ +A +QP+ AL+P+ +NC +++ S G++L+RFLANT+
Sbjct: 383 SVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTS-GQYLSRFLANTT 441
Query: 347 FQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPP 406
F+G +G + V GS+ V +F +W+L+ DP G P W +GSW+ G++ ++ G
Sbjct: 442 FRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYG------- 494
Query: 407 PPQGAQVWPK----------------LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGT 450
+WP+ LRVVTL+EHPFVF R+ D++G CPAGQLCLDP T
Sbjct: 495 ------IWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMT 548
Query: 451 NDSATLDALFAAL--ANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGAL 508
NDS+TLD+LF++L +N + P +KCCYGYCIDLLE++AED FDF+LY+VGDGKYGA
Sbjct: 549 NDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW 608
Query: 509 RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGA 568
++G WTGLVGDLL G AHMAVTSFSIN+ARSQV+DFTSPFFSTSLGI+VR RDTA+PIGA
Sbjct: 609 KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGA 668
Query: 569 FMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILF 628
FMWPLHW+ WLG+F ALH+TA+FLT+YEW+SP+GLTP+GRNRS VFS+SSALN+CYA+LF
Sbjct: 669 FMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLF 728
Query: 629 RRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHP 688
RTV+ K PKC TGR LMNLWAIFC+ LS+YTANLAAVMVG+K +EELSGIHDPKLHHP
Sbjct: 729 GRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP 788
Query: 689 AQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSL 748
+QGFRFGTV ESSAE Y+++SFP+MH +MRR++ P TP GV L +DP KL+AFIMDK+L
Sbjct: 789 SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKAL 848
Query: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 808
LDYEVSIDADCKLLTVGKPFAIEGYGIGLP NSPLT+N+SE IS+YKS GF+D+LHDKWY
Sbjct: 849 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWY 908
Query: 809 KMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSR 868
++VPCGKR FAVTETLQM I HF+GLFVLLC+G G ++L+++GEH +RL LPRI+ S+
Sbjct: 909 RVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSK 968
Query: 869 LQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARRAV 928
LQYWLHTSQ++HRA+NT E E + +++ P W + +
Sbjct: 969 LQYWLHTSQRLHRAINTSFIE-------EKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSH 1021
Query: 929 DKERRVRFLLEPA---VVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQPGELQE 985
D R+ F E + + D RE P + G+ + + EL E
Sbjct: 1022 DNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSE 1081
Query: 986 LERRIEVARERLRQALVRRGQL 1007
LE++I+V R+ L+ A+ R+ +L
Sbjct: 1082 LEKQIQVIRQELQLAVSRKTEL 1103
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor [Homo
sapiens]
Length = 1336
Score = 288 bits (737), Expect = 2e-77
Identities = 291/1030 (28%), Positives = 443/1030 (43%), Gaps = 119/1030 (11%)
Query: 14 ALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPRLPHNLSLE 73
A GPG AGG P G LGG+ L L + A A A L A A L +
Sbjct: 32 APGPGGAGG---PGG---GLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVR 85
Query: 74 LVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ--LHFLAAATETPVLSLL 131
V DP SL LC L V ++ ++R + L FL+A T P+++ +
Sbjct: 86 PVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVA-V 144
Query: 132 RREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPG------ 185
A L L S E L V+ VL+ + W T+ PG
Sbjct: 145 HGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDW--TSFVAVTTRAPGHRAFLS 202
Query: 186 -------GLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLL 238
G + W R L LD G+A L A+L ++A + LL
Sbjct: 203 YIEVLTDGSLVGWEHRGA----LTLD---PGAGEAVLSAQLRSVSAQIR---------LL 246
Query: 239 GCDIARARRVLEAVP------PGPHWLL-----------GTPLPPKALP-TAGLPPGLLA 280
C A V A G W + G P P LP A LP GL A
Sbjct: 247 FCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFA 306
Query: 281 LGEVA-RPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLA 339
+ R L + V +VAR G+ A ++ L P D + G L
Sbjct: 307 VRSAGWRDDLARRVAAGVAVVAR--GAQALLRDYGFL---PELGHDCRAQNRTHRGESLH 361
Query: 340 RFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPG 399
R+ N ++ R + ++ V SL RD W VGSW L L+
Sbjct: 362 RYFMNITWDNRD---YSFNEDGFLVNPSLVVISLTRD----RTWEVVGSWEQQTLRLKYP 414
Query: 400 GASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDAL 459
S Q L V TL E PFV D P C+ + L+
Sbjct: 415 LWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPAD-----PISGTCIRDSVPCRSQLNRT 469
Query: 460 FAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGD 519
+ + APR ++CC G+CID+L+RLA F ++LYLV +GK+G DG W G++G+
Sbjct: 470 HSPPPD--APRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGE 527
Query: 520 LLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGAFMWPLHWSTW 578
+ RA MA+ S +IN RS++VDF+ PF T + +MV R+ T SP AF+ P + W
Sbjct: 528 VFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP-SAFLEPYSPAVW 586
Query: 579 LGVFA-ALHLTALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLCYAILFRRTVS 633
+ +F L + A+ + ++E+ SP G L R + F+ ++ L +A++F +V
Sbjct: 587 VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVP 646
Query: 634 SKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGF- 692
+ P+ T ++++ +WA F ++ L+SYTANLAA M+ ++ + +SG+ D K P + +
Sbjct: 647 VENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYP 706
Query: 693 --RFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLD 750
+FGTV S E I+ ++PDMH++M R++ P + L + KL+AFI D ++L+
Sbjct: 707 PLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAG--KLDAFIYDAAVLN 764
Query: 751 YEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 808
Y D CKL+T+ GK FA GYGI L + S + + ++ I++L W
Sbjct: 765 YMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL 824
Query: 809 KMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSR 868
+ ++ ++ ++ I + AG+F +L + +G +LL EH + + R
Sbjct: 825 SGICHNDKIEVMSS--KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHR 882
Query: 869 LQYWLHTSQKIHRALNTE--PPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARR 926
+ + L S+ ++ + E PP + PS + P P R R
Sbjct: 883 MDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVP----RERA 938
Query: 927 AVDKERRVRFLLEPAVV------------VAPE----ADAEAEAAPREGPVWLCSYGRPP 970
+VD+ RR + P + P+ EA AAPR S PP
Sbjct: 939 SVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLS---PP 995
Query: 971 AARPTGAPQP 980
AA+P P P
Sbjct: 996 AAQPPQKPPP 1005
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 278 bits (710), Expect = 3e-74
Identities = 271/983 (27%), Positives = 432/983 (43%), Gaps = 108/983 (10%)
Query: 59 RAALAPRLPHNLSLEL--VVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ- 115
RA L P+ +L LE+ + +P+SL +C L V ++ E +
Sbjct: 47 RARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQ 106
Query: 116 -LHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDV 174
L F+++ T P+LS+ A L P L LE L VL VL+ + W
Sbjct: 107 ILDFISSQTHVPILSISGGSA-VVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWS-- 163
Query: 175 GLALCRTQDPGGLVALWTSRAGRPPQLV----LDLSRRDTGDAGLRARLAPMAAPVGGEA 230
A+ + PG + L RA V LD+ + G G RAR + + +A
Sbjct: 164 AFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQL--DA 221
Query: 231 PV-------PAAVLLGCDIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGE 283
PV A +L + A+A V PG WL+ P AL + PP +G
Sbjct: 222 PVFVAYCSREEAEVLFAEAAQAG----LVGPGHVWLV----PNLALGSTDAPPATFPVGL 273
Query: 284 VA------RPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGR- 336
++ R L + D V ++A LG+ + + + LPAP + P GP SP R
Sbjct: 274 ISVVTESWRLSLRQKVRDGVAILA--LGAHSYWR-QHGTLPAPAGDCRVHP-GPVSPARE 329
Query: 337 FLARFLANTSFQGRT-----GPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRD 391
R L N +++GR G V + V ++W + VG W
Sbjct: 330 AFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEM------------VGRWEH 377
Query: 392 GQLDLE----PGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDED-GQCPAGQLCL 446
G L ++ P +++ P L V TL E PFV PD G C +
Sbjct: 378 GVLYMKYPVWPRYSASLQPVVDSRH----LTVATLEERPFVIVESPDPGTGGCVPNTVPC 433
Query: 447 DPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYG 506
+N + ++G + CC G+CID+L++LA F ++LYLV +GK+G
Sbjct: 434 RRQSNHT---------FSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG 484
Query: 507 ALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASP 565
G W G++G++ RA MA+ S +IN RS++VDF+ PF T + +MV R+ T SP
Sbjct: 485 KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP 544
Query: 566 IGAFMWPLHWSTWLGVFA-ALHLTALFLTVYEWRSP----YGLTPRGRNRSTVFSYSSAL 620
AF+ P + W+ +F L + A+ + ++E+ SP LT ++ F+ ++
Sbjct: 545 -SAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSV 603
Query: 621 NLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGI 680
L +A++F +V + P+ T ++++ +WA F ++ L+SYTANLAA M+ ++ + +SG+
Sbjct: 604 WLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGL 663
Query: 681 HDPKLHHPAQ---GFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPP 737
D K P FRFGTV S E I+ ++ DMH HM + + + + L
Sbjct: 664 SDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMG-- 721
Query: 738 KLNAFIMDKSLLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYK 795
KL+AFI D ++L+Y D CKL+T+ GK FA GYGI + ++S + + ++
Sbjct: 722 KLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFL 781
Query: 796 SSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
G L W + C V + ++ I + AG+F +L + +G ALL EH
Sbjct: 782 GDGETQKLETVWLSGI-CQNEKNEVMSS-KLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
Query: 856 FRLALPRIRKGSRLQYWLHTSQKIHRALN-----TEPPEGSKEETAEAEPSGPEVEQQQQ 910
+ + S+L + L S+ I+ + PP + + + ++ Q
Sbjct: 840 YWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQA 899
Query: 911 QQDQPT---APEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSYG 967
+D T RA R ++ R P+ P + + P P
Sbjct: 900 ARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRS-GPSPCLPTPDP------- 951
Query: 968 RPPAARPTG-APQPGELQELERR 989
PP PTG P G L RR
Sbjct: 952 -PPEPSPTGWGPPDGGRAALVRR 973
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 258 bits (660), Expect = 2e-68
Identities = 222/823 (26%), Positives = 388/823 (47%), Gaps = 73/823 (8%)
Query: 68 HNLSL--ELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ--LHFLAAAT 123
H+LS+ + + A DP S+ +C + + ++ + E + L F++A T
Sbjct: 60 HHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQT 119
Query: 124 ETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQD 183
TP+L + + + + + + +E V++ +++ + W ++ T
Sbjct: 120 LTPILGIHGGSSMI-MADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYI--FSIVTTYF 176
Query: 184 PGGL-------VALWTSRAGRPPQ--LVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPA 234
PG + S G + L+LD+S D GD+ ++ +L + +P+
Sbjct: 177 PGYQDFVNKIRSTIENSFVGWELEEVLLLDMSL-DDGDSKIQNQLKKLQSPI-------- 227
Query: 235 AVLLGCDIARARRVLEAVPP------GPHWLLGTPLPPKA-LPTAGLPPGLLALG-EVAR 286
+LL C A + E G W++ + + A P GL+++ +
Sbjct: 228 -ILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWD 286
Query: 287 PPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTS 346
L A + D + ++ A A+ + + + +P P + L R+L N +
Sbjct: 287 YGLPARVRDGIAIITTA---ASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT 343
Query: 347 FQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPP 406
F+GR G Q+H + + R W VG W+D L ++ R
Sbjct: 344 FEGRNLSFSEDGY-QMHPKLVIILLNKERK------WERVGKWKDKSLQMKYY-VWPRMC 395
Query: 407 PPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANG 466
P Q L +VTL E PFV D P C+ N +
Sbjct: 396 PETEEQEDDHLSIVTLEEAPFVIVESVD-----PLSGTCM---RNTVPCQKRIVTENKTD 447
Query: 467 SAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAH 526
P ++KCC G+CID+L+++++ F ++LYLV +GK+G +G W G++G+++ RA+
Sbjct: 448 EEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAY 507
Query: 527 MAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGAFMWPLHWSTWLGVFAAL 585
MAV S +IN RS+VVDF+ PF T + +MV R+ T SP AF+ P W+ +F L
Sbjct: 508 MAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSP-SAFLEPFSADVWVMMFVML 566
Query: 586 HL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCP 640
+ +A+ + V+E+ SP G L F+ A+ L + ++F +V + PK
Sbjct: 567 LIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 626
Query: 641 TGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHP---AQGFRFGTV 697
T ++++++WA F ++ L+SYTANLAA M+ ++ +++SG+ D K P + FRFGTV
Sbjct: 627 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTV 686
Query: 698 WESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPKLNAFIMDKSLLDYEVSI 755
S E I+ ++ +MHA+M + + RGV A+L+ KL+AFI D ++L+Y
Sbjct: 687 PNGSTERNIRNNYAEMHAYMGKFN----QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGR 742
Query: 756 DADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPC 813
D CKL+T+ GK FA GYGI + ++S + I + G ++ L W + C
Sbjct: 743 DEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGI-C 801
Query: 814 GKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 802 HNEKNEVMSS-QLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 250 bits (638), Expect = 6e-66
Identities = 234/840 (27%), Positives = 387/840 (46%), Gaps = 115/840 (13%)
Query: 70 LSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELL--QLHFLAAATETPV 127
L + +V DP SL +C + + L+ + E + L F+++ T P+
Sbjct: 65 LDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPI 124
Query: 128 LSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGL 187
L + A + +P + + ++ V++ ++Q + W +L T PG
Sbjct: 125 LGI-HGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHV--FSLVTTIFPGYR 181
Query: 188 -------VALWTSRAGRPPQLVLDLSRRDTG--DAGLRARLAPMAAPVGGEAPVPAAVLL 238
+ S G Q V+ L DT DA + +L + + V +LL
Sbjct: 182 EFISFVKTTVDNSFVGWDMQNVITL---DTSFEDAKTQVQLKKIHSSV---------ILL 229
Query: 239 GCDIARARRVL-EAVPPGP-----HWLL------GTPLPPKALPTAGLPPGLLALG-EVA 285
C A +L EA G W++ T L PK P+ GL+++ +
Sbjct: 230 YCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPS-----GLISVSYDDW 284
Query: 286 RPPLEAAIHDIVQLVARALGSAAQVQPKRALLP-APVNCGDLQPAGPESPGRFLARFLAN 344
LEA + D + ++ A S + K + +P A +C Q PE P L F+ N
Sbjct: 285 DYSLEARVRDGIGILTTAASSMLE---KFSYIPEAKASCYG-QMERPEVPMHTLHPFMVN 340
Query: 345 TSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASAR 404
++ G+ G QVH V + R+ W VG W + L L
Sbjct: 341 VTWDGKDLSFTEEGY-QVHPRLVVIVLNKDRE------WEKVGKWENHTLSLRHA----- 388
Query: 405 PPPPQGAQVWPK-------------LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTN 451
VWP+ L +VTL E PFV D D P + C+
Sbjct: 389 --------VWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID-----PLTETCV----- 430
Query: 452 DSATLDALFAALANGSAPRAL--RKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR 509
T+ N S + +KCC G+CID+L++L+ F ++LYLV +GK+G
Sbjct: 431 -RNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
Query: 510 DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGA 568
+ W G++G+++ RA MAV S +IN RS+VVDF+ PF T + +MV R+ T SP A
Sbjct: 490 NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSP-SA 548
Query: 569 FMWPLHWSTWLGVFAALHL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLC 623
F+ P S W+ +F L + +A+ + V+E+ SP G L F+ A+ L
Sbjct: 549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLL 608
Query: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
+ ++F +V + PK T ++++++WA F ++ L+SYTANLAA M+ ++ ++++G+ D
Sbjct: 609 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668
Query: 684 KLHHP---AQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPK 738
K P + FRFGTV S E I+ ++P MH +M + + +GV A+++ K
Sbjct: 669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFN----QKGVEDALVSLKTGK 724
Query: 739 LNAFIMDKSLLDYEVSIDADCKLLTVGKP--FAIEGYGIGLPQNSPLTSNLSEFISRYKS 796
L+AFI D ++L+Y+ D CKL+T+G FA GYGI L + SP + + ++
Sbjct: 725 LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVG 784
Query: 797 SGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
G ++ L W + C V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 785 DGEMEELETLWLTGI-CHNEKNEVMSS-QLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 250 bits (638), Expect = 6e-66
Identities = 234/840 (27%), Positives = 387/840 (46%), Gaps = 115/840 (13%)
Query: 70 LSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELL--QLHFLAAATETPV 127
L + +V DP SL +C + + L+ + E + L F+++ T P+
Sbjct: 65 LDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPI 124
Query: 128 LSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGL 187
L + A + +P + + ++ V++ ++Q + W +L T PG
Sbjct: 125 LGI-HGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHV--FSLVTTIFPGYR 181
Query: 188 -------VALWTSRAGRPPQLVLDLSRRDTG--DAGLRARLAPMAAPVGGEAPVPAAVLL 238
+ S G Q V+ L DT DA + +L + + V +LL
Sbjct: 182 EFISFVKTTVDNSFVGWDMQNVITL---DTSFEDAKTQVQLKKIHSSV---------ILL 229
Query: 239 GCDIARARRVL-EAVPPGP-----HWLL------GTPLPPKALPTAGLPPGLLALG-EVA 285
C A +L EA G W++ T L PK P+ GL+++ +
Sbjct: 230 YCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPS-----GLISVSYDDW 284
Query: 286 RPPLEAAIHDIVQLVARALGSAAQVQPKRALLP-APVNCGDLQPAGPESPGRFLARFLAN 344
LEA + D + ++ A S + K + +P A +C Q PE P L F+ N
Sbjct: 285 DYSLEARVRDGIGILTTAASSMLE---KFSYIPEAKASCYG-QMERPEVPMHTLHPFMVN 340
Query: 345 TSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASAR 404
++ G+ G QVH V + R+ W VG W + L L
Sbjct: 341 VTWDGKDLSFTEEGY-QVHPRLVVIVLNKDRE------WEKVGKWENHTLSLRHA----- 388
Query: 405 PPPPQGAQVWPK-------------LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTN 451
VWP+ L +VTL E PFV D D P + C+
Sbjct: 389 --------VWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID-----PLTETCV----- 430
Query: 452 DSATLDALFAALANGSAPRAL--RKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR 509
T+ N S + +KCC G+CID+L++L+ F ++LYLV +GK+G
Sbjct: 431 -RNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
Query: 510 DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGA 568
+ W G++G+++ RA MAV S +IN RS+VVDF+ PF T + +MV R+ T SP A
Sbjct: 490 NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSP-SA 548
Query: 569 FMWPLHWSTWLGVFAALHL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLC 623
F+ P S W+ +F L + +A+ + V+E+ SP G L F+ A+ L
Sbjct: 549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLL 608
Query: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
+ ++F +V + PK T ++++++WA F ++ L+SYTANLAA M+ ++ ++++G+ D
Sbjct: 609 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668
Query: 684 KLHHP---AQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPK 738
K P + FRFGTV S E I+ ++P MH +M + + +GV A+++ K
Sbjct: 669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFN----QKGVEDALVSLKTGK 724
Query: 739 LNAFIMDKSLLDYEVSIDADCKLLTVGKP--FAIEGYGIGLPQNSPLTSNLSEFISRYKS 796
L+AFI D ++L+Y+ D CKL+T+G FA GYGI L + SP + + ++
Sbjct: 725 LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVG 784
Query: 797 SGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
G ++ L W + C V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 785 DGEMEELETLWLTGI-CHNEKNEVMSS-QLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 250 bits (638), Expect = 6e-66
Identities = 234/840 (27%), Positives = 387/840 (46%), Gaps = 115/840 (13%)
Query: 70 LSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELL--QLHFLAAATETPV 127
L + +V DP SL +C + + L+ + E + L F+++ T P+
Sbjct: 65 LDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPI 124
Query: 128 LSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGL 187
L + A + +P + + ++ V++ ++Q + W +L T PG
Sbjct: 125 LGI-HGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHV--FSLVTTIFPGYR 181
Query: 188 -------VALWTSRAGRPPQLVLDLSRRDTG--DAGLRARLAPMAAPVGGEAPVPAAVLL 238
+ S G Q V+ L DT DA + +L + + V +LL
Sbjct: 182 EFISFVKTTVDNSFVGWDMQNVITL---DTSFEDAKTQVQLKKIHSSV---------ILL 229
Query: 239 GCDIARARRVL-EAVPPGP-----HWLL------GTPLPPKALPTAGLPPGLLALG-EVA 285
C A +L EA G W++ T L PK P+ GL+++ +
Sbjct: 230 YCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPS-----GLISVSYDDW 284
Query: 286 RPPLEAAIHDIVQLVARALGSAAQVQPKRALLP-APVNCGDLQPAGPESPGRFLARFLAN 344
LEA + D + ++ A S + K + +P A +C Q PE P L F+ N
Sbjct: 285 DYSLEARVRDGIGILTTAASSMLE---KFSYIPEAKASCYG-QMERPEVPMHTLHPFMVN 340
Query: 345 TSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASAR 404
++ G+ G QVH V + R+ W VG W + L L
Sbjct: 341 VTWDGKDLSFTEEGY-QVHPRLVVIVLNKDRE------WEKVGKWENHTLSLRHA----- 388
Query: 405 PPPPQGAQVWPK-------------LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTN 451
VWP+ L +VTL E PFV D D P + C+
Sbjct: 389 --------VWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID-----PLTETCV----- 430
Query: 452 DSATLDALFAALANGSAPRAL--RKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR 509
T+ N S + +KCC G+CID+L++L+ F ++LYLV +GK+G
Sbjct: 431 -RNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
Query: 510 DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGA 568
+ W G++G+++ RA MAV S +IN RS+VVDF+ PF T + +MV R+ T SP A
Sbjct: 490 NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSP-SA 548
Query: 569 FMWPLHWSTWLGVFAALHL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLC 623
F+ P S W+ +F L + +A+ + V+E+ SP G L F+ A+ L
Sbjct: 549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLL 608
Query: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
+ ++F +V + PK T ++++++WA F ++ L+SYTANLAA M+ ++ ++++G+ D
Sbjct: 609 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668
Query: 684 KLHHP---AQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPK 738
K P + FRFGTV S E I+ ++P MH +M + + +GV A+++ K
Sbjct: 669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFN----QKGVEDALVSLKTGK 724
Query: 739 LNAFIMDKSLLDYEVSIDADCKLLTVGKP--FAIEGYGIGLPQNSPLTSNLSEFISRYKS 796
L+AFI D ++L+Y+ D CKL+T+G FA GYGI L + SP + + ++
Sbjct: 725 LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVG 784
Query: 797 SGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
G ++ L W + C V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 785 DGEMEELETLWLTGI-CHNEKNEVMSS-QLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 243 bits (621), Expect = 5e-64
Identities = 197/725 (27%), Positives = 340/725 (46%), Gaps = 65/725 (8%)
Query: 242 IARARRVLEAVPPGPHWLLGT-PLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
+ RA +L G WL+G + AL A P G+L L + A I D V +V
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGEREISGNALRYA--PDGILGLQLINGKNESAHISDAVGVV 288
Query: 301 ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSF-QGRTGPVWVTGS 359
A+A+ + K + P C + G R L ++ + G TG V
Sbjct: 289 AQAVHELLE---KENITDPPRGC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNED 343
Query: 360 SQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRV 419
+ + + R + + + + PGG + +P +G Q+ +L++
Sbjct: 344 GDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP---RGYQMSTRLKI 400
Query: 420 VTLLEHPFVFARDPDEDGQCPAG--------QLCLDPGTNDSATLDALFAALANGSAPRA 471
VT+ + PFV+ + DG C + + G ND++ GS
Sbjct: 401 VTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSP----------GSPRHT 450
Query: 472 LRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR------DGRWTGLVGDLLAGRA 525
+ +CCYG+CIDLL +LA F +E++LV DGK+G W G++G+LL+G+A
Sbjct: 451 VPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQA 510
Query: 526 HMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAAL 585
M V +IN+ R+Q ++F+ PF L I+V+ S + +FM P + WL V ++
Sbjct: 511 DMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSV 570
Query: 586 HLTALFLTVYEWRSPYGL--TPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGR 643
H+ A+ L + + SP+G + SSA+ + +L + P+ + R
Sbjct: 571 HVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 644 LLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAE 703
+L +WA F +++++SYTANLAA +V D+ E ++GI+DP+L +P+ F + TV +SS +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 704 AYIKK--SFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKL 761
Y ++ M+ HM +H+ + + + + KL+AFI D ++L++E S C L
Sbjct: 691 IYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDL 746
Query: 762 LTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVT 821
+T G+ F G+GIG+ ++SP N+S I + +GF++ L W + C R A
Sbjct: 747 VTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA-- 804
Query: 822 ETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQY-----WLHTS 876
++ + AG+F+L+ G+ + + E A+ R R RK +L + W
Sbjct: 805 -PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDAR-RKQMQLAFAAVNVWRKNL 862
Query: 877 QKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRA----------RR 926
Q R P+ K+ T A S ++++ + T+ G + A RR
Sbjct: 863 Q--DRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRR 920
Query: 927 AVDKE 931
A+++E
Sbjct: 921 AIERE 925
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 242 bits (617), Expect = 2e-63
Identities = 187/671 (27%), Positives = 319/671 (47%), Gaps = 53/671 (7%)
Query: 242 IARARRVLEAVPPGPHWLLGT-PLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
+ RA +L G WL+G + AL A P G+L L + A I D V +V
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGEREISGNALRYA--PDGILGLQLINGKNESAHISDAVGVV 288
Query: 301 ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSF-QGRTGPVWVTGS 359
A+A+ + K + P C + G R L ++ + G TG V
Sbjct: 289 AQAVHELLE---KENITDPPRGC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNED 343
Query: 360 SQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRV 419
+ + + R + + + + PGG + +P +G Q+ +L++
Sbjct: 344 GDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP---RGYQMSTRLKI 400
Query: 420 VTLLEHPFVFARDPDEDGQCPAG--------QLCLDPGTNDSATLDALFAALANGSAPRA 471
VT+ + PFV+ + DG C + + G ND++ GS
Sbjct: 401 VTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSP----------GSPRHT 450
Query: 472 LRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR------DGRWTGLVGDLLAGRA 525
+ +CCYG+CIDLL +LA F +E++LV DGK+G W G++G+LL+G+A
Sbjct: 451 VPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQA 510
Query: 526 HMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAAL 585
M V +IN+ R+Q ++F+ PF L I+V+ S + +FM P + WL V ++
Sbjct: 511 DMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSV 570
Query: 586 HLTALFLTVYEWRSPYGL--TPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGR 643
H+ A+ L + + SP+G + SSA+ + +L + P+ + R
Sbjct: 571 HVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 644 LLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAE 703
+L +WA F +++++SYTANLAA +V D+ E ++GI+DP+L +P+ F + TV +SS +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 704 AYIKK--SFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKL 761
Y ++ M+ HM +H+ + + + + KL+AFI D ++L++E S C L
Sbjct: 691 IYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDL 746
Query: 762 LTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVT 821
+T G+ F G+GIG+ ++SP N+S I + +GF++ L W + C R A
Sbjct: 747 VTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA-- 804
Query: 822 ETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQY-----WLHTS 876
++ + AG+F+L+ G+ + + E A+ R R RK +L + W
Sbjct: 805 -PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDAR-RKQMQLAFAAVNVWRKNL 862
Query: 877 QKIHRALNTEP 887
Q+ H T P
Sbjct: 863 QQYHPTDITGP 873
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 241 bits (615), Expect = 3e-63
Identities = 178/636 (27%), Positives = 307/636 (48%), Gaps = 47/636 (7%)
Query: 242 IARARRVLEAVPPGPHWLLGT-PLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV 300
+ RA +L G WL+G + AL A P G+L L + A I D V +V
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGEREISGNALRYA--PDGILGLQLINGKNESAHISDAVGVV 288
Query: 301 ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSF-QGRTGPVWVTGS 359
A+A+ + K + P C + G R L ++ + G TG V
Sbjct: 289 AQAVHELLE---KENITDPPRGC--VGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNED 343
Query: 360 SQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRV 419
+ + + R + + + + PGG + +P +G Q+ +L++
Sbjct: 344 GDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP---RGYQMSTRLKI 400
Query: 420 VTLLEHPFVFARDPDEDGQCPAG--------QLCLDPGTNDSATLDALFAALANGSAPRA 471
VT+ + PFV+ + DG C + + G ND++ GS
Sbjct: 401 VTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSP----------GSPRHT 450
Query: 472 LRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR------DGRWTGLVGDLLAGRA 525
+ +CCYG+CIDLL +LA F +E++LV DGK+G W G++G+LL+G+A
Sbjct: 451 VPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQA 510
Query: 526 HMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAAL 585
M V +IN+ R+Q ++F+ PF L I+V+ S + +FM P + WL V ++
Sbjct: 511 DMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSV 570
Query: 586 HLTALFLTVYEWRSPYGL--TPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGR 643
H+ A+ L + + SP+G + SSA+ + +L + P+ + R
Sbjct: 571 HVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSAR 630
Query: 644 LLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAE 703
+L +WA F +++++SYTANLAA +V D+ E ++GI+DP+L +P+ F + TV +SS +
Sbjct: 631 ILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 690
Query: 704 AYIKK--SFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKL 761
Y ++ M+ HM +H+ + + + + KL+AFI D ++L++E S C L
Sbjct: 691 IYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEAS--QKCDL 746
Query: 762 LTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVT 821
+T G+ F G+GIG+ ++SP N+S I + +GF++ L W + C R A
Sbjct: 747 VTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA-- 804
Query: 822 ETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFR 857
++ + AG+F+L+ G+ + + E A+ R
Sbjct: 805 -PATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKR 839
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 165 bits (417), Expect = 2e-40
Identities = 119/401 (29%), Positives = 197/401 (49%), Gaps = 30/401 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ F ++L +VGDGKYGA RD W G+VG+L+ G+A +A+ +I
Sbjct: 397 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RDADTKIWNGMVGELVYGKADIAIAPLTI 455
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 456 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 515
Query: 587 LTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL 644
L + F + YEW + R S + N + L F R +P+ +GR+
Sbjct: 516 LVSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRI 574
Query: 645 LMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704
+ +W F L+++SSYTANLAA + ++ + D +GT+ S +
Sbjct: 575 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKE 631
Query: 705 YIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSID 756
+ ++S F M +MR TT GVA + K A++++ ++ +Y +
Sbjct: 632 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQR 689
Query: 757 ADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCGK 815
C + VG +GYGI P+ S L + ++ + + G +D L +K WY CG
Sbjct: 690 KPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA 749
Query: 816 RVFAVTE-TLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
+ E T +S+ + AG+F +L GLG A+L +L E +
Sbjct: 750 KDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 790
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 165 bits (417), Expect = 2e-40
Identities = 119/401 (29%), Positives = 197/401 (49%), Gaps = 30/401 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ F ++L +VGDGKYGA RD W G+VG+L+ G+A +A+ +I
Sbjct: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RDADTKIWNGMVGELVYGKADIAIAPLTI 502
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562
Query: 587 LTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL 644
L + F + YEW + R S + N + L F R +P+ +GR+
Sbjct: 563 LVSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRI 621
Query: 645 LMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704
+ +W F L+++SSYTANLAA + ++ + D +GT+ S +
Sbjct: 622 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKE 678
Query: 705 YIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSID 756
+ ++S F M +MR TT GVA + K A++++ ++ +Y +
Sbjct: 679 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQR 736
Query: 757 ADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCGK 815
C + VG +GYGI P+ S L + ++ + + G +D L +K WY CG
Sbjct: 737 KPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA 796
Query: 816 RVFAVTE-TLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
+ E T +S+ + AG+F +L GLG A+L +L E +
Sbjct: 797 KDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 163 bits (412), Expect = 9e-40
Identities = 119/401 (29%), Positives = 196/401 (48%), Gaps = 30/401 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ F ++L +VGDGKYGA RD W G+VG+L+ G+A +A+ +I
Sbjct: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RDADTKIWNGMVGELVYGKADIAIAPLTI 502
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562
Query: 587 LTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL 644
L + F + YEW + R S + N + L F R +P+ +GR+
Sbjct: 563 LVSRF-SPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRI 621
Query: 645 LMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704
+ +W F L+++SSYTANLAA + ++ + D +GT+ S +
Sbjct: 622 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKE 678
Query: 705 YIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSID 756
+ ++S F M +MR TT GVA + K A++++ ++ +Y +
Sbjct: 679 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQR 736
Query: 757 ADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCGK 815
C + VG +GYGI P+ S L + ++ + + G +D L +K WY CG
Sbjct: 737 KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796
Query: 816 RVFAVTE-TLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
E T +S+ + AG+F +L GLG A+L +L E +
Sbjct: 797 GGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 159 bits (402), Expect = 1e-38
Identities = 122/431 (28%), Positives = 206/431 (47%), Gaps = 34/431 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDG---RWTGLVGDLLAGRAHMAVTSFSI 534
GYC++L +A+ + + L +V DGKYGA RD W G+VG+L+ GRA +AV +I
Sbjct: 437 GYCVELAAEIAKHVGYSYRLEIVSDGKYGA-RDPDTKAWNGMVGELVYGRADVAVAPLTI 495
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 555
Query: 587 LTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL 644
L + F + YEW S R + S + N + L F + +P+ +GR+
Sbjct: 556 LVSRF-SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 614
Query: 645 LMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704
+ +W F L+++SSYTANLAA + ++ + D +GT+ S +
Sbjct: 615 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLEAGSTKE 671
Query: 705 YIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSID 756
+ ++S F M +M+ TT G+ + K A++++ ++ +Y +
Sbjct: 672 FFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY-AYLLESTMNEY-IEQR 729
Query: 757 ADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCG- 814
C + VG +GYGI P+ S L ++ + + G +D L K WY CG
Sbjct: 730 KPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGS 789
Query: 815 KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLH 874
K + +T +S+ + AG+F +L GLG A+L +L E + + + KG + L
Sbjct: 790 KDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKG----FCLI 845
Query: 875 TSQKIHRALNT 885
Q I+ A+ T
Sbjct: 846 PQQSINEAIRT 856
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 158 bits (399), Expect = 3e-38
Identities = 121/431 (28%), Positives = 207/431 (48%), Gaps = 34/431 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDG---RWTGLVGDLLAGRAHMAVTSFSI 534
GYC++L +A+ + + L +V DGKYGA RD W G+VG+L+ GRA +AV +I
Sbjct: 437 GYCVELAAEIAKHVGYSYRLEIVSDGKYGA-RDPDTKAWNGMVGELVYGRADVAVAPLTI 495
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 555
Query: 587 LTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAIL--FRRTVSSKTPKCPTGRL 644
L + F + YEW S R + S + N + L F + +P+ +GR+
Sbjct: 556 LVSRF-SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 614
Query: 645 LMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704
+ +W F L+++SSYTANLAA + ++ + D +GT+ S +
Sbjct: 615 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLEAGSTKE 671
Query: 705 YIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSID 756
+ ++S F M +M+ TT G+ + K A++++ ++ +Y +
Sbjct: 672 FFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY-AYLLESTMNEY-IEQR 729
Query: 757 ADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCGK 815
C + VG +GYGI P+ S L + ++ + + G +D L +K WY CG
Sbjct: 730 KPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 789
Query: 816 -RVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLH 874
+ +T +S+ + AG+F +L GLG A+L +L E + + + KG + L
Sbjct: 790 GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKG----FCLI 845
Query: 875 TSQKIHRALNT 885
Q I+ A+ T
Sbjct: 846 PQQSINEAIRT 856
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 157 bits (398), Expect = 4e-38
Identities = 121/432 (28%), Positives = 207/432 (47%), Gaps = 35/432 (8%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD--GRWTGLVGDLLAGRAHMAVTSFSIN 535
GYCIDLL L+ F +E+ LV DGKYGA D G+W G+V +L+ +A +AV +I
Sbjct: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
Query: 536 SARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHL 587
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
Query: 588 TALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMN 647
A F + YEW +P+ P F+ ++ L ++ S PK + R++
Sbjct: 581 IARF-SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGG 638
Query: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
+W F L+++SSYTANLAA + ++ + D + +G V + + + K
Sbjct: 639 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVEDGATMTFFK 695
Query: 708 KS----FPDMHAHM--RRHS--APTTPRGV-AMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758
KS + M A M RR S + G+ +LTSD AF+M+ + +++ +
Sbjct: 696 KSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD----YAFLMESTTIEFVT--QRN 749
Query: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818
C L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 750 CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE-- 807
Query: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKG---SRLQYWLHT 875
E + + + G+F++L GL ++ ++GE + ++ K S + L
Sbjct: 808 ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRM 867
Query: 876 SQKIHRALNTEP 887
S K R L +P
Sbjct: 868 SLKCQRRLKHKP 879
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 157 bits (398), Expect = 4e-38
Identities = 117/415 (28%), Positives = 202/415 (48%), Gaps = 34/415 (8%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD--GRWTGLVGDLLAGRAHMAVTSFSIN 535
GYCIDLL L+ F +E+ LV DGKYGA D G+W G+V +L+ +A +AV +I
Sbjct: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
Query: 536 SARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHL 587
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
Query: 588 TALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMN 647
A F + YEW +P+ P F+ ++ L ++ S PK + R++
Sbjct: 581 IARF-SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGG 638
Query: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
+W F L+++SSYTANLAA + ++ + D + +G V + + + K
Sbjct: 639 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVEDGATMTFFK 695
Query: 708 KS----FPDMHAHM--RRHS--APTTPRGV-AMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758
KS + M A M RR S + G+ +LTSD AF+M+ + +++ +
Sbjct: 696 KSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD----YAFLMESTTIEFVT--QRN 749
Query: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818
C L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 750 CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE-- 807
Query: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWL 873
E + + + G+F++L GL ++ ++GE + ++ K S + WL
Sbjct: 808 ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKESSI--WL 860
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 157 bits (398), Expect = 4e-38
Identities = 118/409 (28%), Positives = 203/409 (49%), Gaps = 44/409 (10%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ ++L +VGDGKYGA RD W G+VG+L+ GRA +AV +I
Sbjct: 453 GYCVDLAYEIAKHVRIKYKLSIVGDGKYGA-RDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 571
Query: 587 LTALFLTVYEW---------RSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKT 636
L + F + YEW R P P N +F+ +L +++ F + +
Sbjct: 572 LVSRF-SPYEWHLEDNNEEPRDPQS-PPDPPNEFGIFN-----SLWFSLGAFMQQGCDIS 624
Query: 637 PKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGT 696
P+ +GR++ +W F L+++SSYTANLAA + ++ + D +GT
Sbjct: 625 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGT 681
Query: 697 VWESSAEAYIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSL 748
+ S + + ++S + M ++M+ TT GVA + K AF+++ ++
Sbjct: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTM 740
Query: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-W 807
+Y + C + VG +GYG+ P+ S L + ++ + + G +D L +K W
Sbjct: 741 NEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWW 799
Query: 808 YKMVPCG-KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
Y CG K + +T +S+ + AG+F +L GLG A++ +L E +
Sbjct: 800 YDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 155 bits (393), Expect = 1e-37
Identities = 114/406 (28%), Positives = 203/406 (50%), Gaps = 40/406 (9%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ +++ +V DGKYGA RD W G+VG+L+ G+A +A+ +I
Sbjct: 445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGA-RDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 563
Query: 587 LTALFLTVYEWRS------PYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKC 639
L + F + YEW + G + + N +F+ +L +++ F + +P+
Sbjct: 564 LVSRF-SPYEWHTEEPEDGKEGPSDQPPNEFGIFN-----SLWFSLGAFMQQGCDISPRS 617
Query: 640 PTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWE 699
+GR++ +W F L+++SSYTANLAA + ++ + D +GT+
Sbjct: 618 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDS 674
Query: 700 SSAEAYIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDY 751
S + + ++S + M +MR TT GVA + K AF+++ ++ +Y
Sbjct: 675 GSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKF-AFLLESTMNEY 733
Query: 752 EVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKM 810
+ C + VG +GYG+ P+ S L + ++ + + +G +D L +K WY
Sbjct: 734 -IEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDK 792
Query: 811 VPCG-KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
CG K + +T +S+ + AG+F +L GLG A+L +L E +
Sbjct: 793 GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 838
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 155 bits (392), Expect = 2e-37
Identities = 117/409 (28%), Positives = 202/409 (49%), Gaps = 44/409 (10%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ ++L +VGDGKYGA RD W G+VG+L+ GRA +AV +I
Sbjct: 453 GYCVDLAYEIAKHVRIKYKLSIVGDGKYGA-RDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 571
Query: 587 LTALFLTVYEW---------RSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKT 636
L + F + YEW R P P N +F+ +L +++ F + +
Sbjct: 572 LVSRF-SPYEWHLEDNNEEPRDPQS-PPDPPNEFGIFN-----SLWFSLGAFMQQGCDIS 624
Query: 637 PKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGT 696
P+ +GR++ +W F L+++SSYTANLAA + ++ + D +GT
Sbjct: 625 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGT 681
Query: 697 VWESSAEAYIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSL 748
+ S + + ++S + M ++M+ TT GVA + K AF+++ ++
Sbjct: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKF-AFLLESTM 740
Query: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-W 807
+Y + C + VG +GYG+ P+ S L + ++ + + G +D L +K W
Sbjct: 741 NEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWW 799
Query: 808 YKMVPCGK-RVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
Y CG + +T +S+ + AG+F +L GLG A++ +L E +
Sbjct: 800 YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 154 bits (389), Expect = 4e-37
Identities = 139/536 (25%), Positives = 225/536 (41%), Gaps = 65/536 (12%)
Query: 335 GRFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWR--DG 392
GRF+ F+ ++G TG + +S + + SL+ D VG W DG
Sbjct: 360 GRFM-NFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED-----GLEKVGVWSPADG 413
Query: 393 QLDLEPGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTND 452
E A R P + L V T+LE PFV R D ND
Sbjct: 414 LNITEV--AKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLY-----------GND 460
Query: 453 SATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-G 511
GYCIDLL+ LA F +E+ LV DGKYGA D G
Sbjct: 461 RFE----------------------GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKG 498
Query: 512 RWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFM 570
+W G+V +L+ +A +AV +I R + +DF+ PF + + I+ R + +P + +F+
Sbjct: 499 QWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFL 558
Query: 571 WPLHWSTW-------LGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLC 623
PL W LGV L + A F + YEW + P F+ ++
Sbjct: 559 NPLSPDIWMYVLLAYLGVSCVLFVIARF-SPYEWYDAHPCNPGSEVVENNFTLLNSFWFG 617
Query: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
L ++ S PK + R++ +W F L+++SSYTANLAA + ++ + D
Sbjct: 618 MGSLMQQG-SELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676
Query: 684 KLHHPAQGFRFGTVWESSAEAYIKKS----FPDMHAHMRRHSAPTTPRGVAMLTSDPPKL 739
+ +G V + + + KKS F M A M + +
Sbjct: 677 AKQTKIE---YGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTAD 733
Query: 740 NAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGF 799
A +M+ + ++Y +C L +G +GYGIG P SP ++ I + +
Sbjct: 734 YALLMESTTIEYVT--QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDK 791
Query: 800 IDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
+ ++ +KW++ C + E + I G+F++L GL ++L ++GE +
Sbjct: 792 LHIMKEKWWRGSGCPEE--ENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY 845
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 154 bits (388), Expect = 5e-37
Identities = 120/437 (27%), Positives = 213/437 (48%), Gaps = 41/437 (9%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 534
GYC+DL +A+ +++ +V DGKYGA RD W G+VG+L+ G+A +A+ +I
Sbjct: 445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGA-RDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 535 NSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALH 586
R +V+DF+ PF S + IM++ + P + +F+ PL + W +GV L
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 563
Query: 587 LTALFLTVYEWRS------PYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKC 639
L + F + YEW + G + + N +F+ +L +++ F + +P+
Sbjct: 564 LVSRF-SPYEWHTEEPEDGKEGPSDQPPNEFGIFN-----SLWFSLGAFMQQGCDISPRS 617
Query: 640 PTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWE 699
+GR++ +W F L+++SSYTANLAA + ++ + D +GT+
Sbjct: 618 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA---KQTEIAYGTLDS 674
Query: 700 SSAEAYIKKS----FPDMHAHMRRHS----APTTPRGVAMLTSDPPKLNAFIMDKSLLDY 751
S + + ++S + M +MR TT GVA + K AF+++ ++ +Y
Sbjct: 675 GSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKF-AFLLESTMNEY 733
Query: 752 EVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKM 810
+ C + VG +GYG+ P+ S L + ++ + + G +D L +K WY
Sbjct: 734 -IEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDK 792
Query: 811 VPCGK-RVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF-FRLALPRIRKGSR 868
CG + +T +S+ + AG+F +L GLG A+L +L E + R R++
Sbjct: 793 GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKS 852
Query: 869 LQYWLHTSQKIHRALNT 885
Q + TS + + L T
Sbjct: 853 AQTFNPTSSQNTQNLAT 869
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 153 bits (387), Expect = 7e-37
Identities = 110/396 (27%), Positives = 189/396 (47%), Gaps = 31/396 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINS 536
GYC+DLL+ L+ F +++ LV DGKYGA D G W G+V +L+ RA +AV +I
Sbjct: 462 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 521
Query: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHLT 588
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 522 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 581
Query: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNL 648
A F T YEW +P+ P F+ ++ L ++ S PK + R++ +
Sbjct: 582 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGI 639
Query: 649 WAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK 708
W F L+++SSYTANLAA + ++ + D + +G V + S + KK
Sbjct: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVRDGSTMTFFKK 696
Query: 709 S----FPDMHAHMRRHSAPTTPRG-----VAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
S + M A M R +LT+D A +M+ + ++Y +C
Sbjct: 697 SKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD----YALLMESTSIEYVT--QRNC 750
Query: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 751 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE--D 808
Query: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
E + + + G+F++L GL ++ ++GE +
Sbjct: 809 NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 844
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 153 bits (387), Expect = 7e-37
Identities = 110/396 (27%), Positives = 189/396 (47%), Gaps = 31/396 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINS 536
GYC+DLL+ L+ F +++ LV DGKYGA D G W G+V +L+ RA +AV +I
Sbjct: 477 GYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITY 536
Query: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHLT 588
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVI 596
Query: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNL 648
A F T YEW +P+ P F+ ++ L ++ S PK + R++ +
Sbjct: 597 ARF-TPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGI 654
Query: 649 WAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK 708
W F L+++SSYTANLAA + ++ + D + +G V + S + KK
Sbjct: 655 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVRDGSTMTFFKK 711
Query: 709 S----FPDMHAHMRRHSAPTTPRG-----VAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
S + M A M R +LT+D A +M+ + ++Y +C
Sbjct: 712 SKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD----YALLMESTSIEYVT--QRNC 765
Query: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 766 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE--D 823
Query: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAF 855
E + + + G+F++L GL ++ ++GE +
Sbjct: 824 NKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 150 bits (379), Expect = 6e-36
Identities = 109/393 (27%), Positives = 187/393 (47%), Gaps = 30/393 (7%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536
G+C+D+L+ LAE F++++ LVGDG YG +G WTG+VG+L+A +A +AV +I +
Sbjct: 446 GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITA 505
Query: 537 ARSQVVDFTSPFFSTSLGIMVRAR--------DTASPIGAFMWPLHWSTWLGVFAALHLT 588
R +V+DF+ PF + + I+ R P +W +L V L L
Sbjct: 506 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565
Query: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKCPTGRLLMN 647
A LT YEW SP+ +GR V YS +L + + F + S+ P+ + R +
Sbjct: 566 AR-LTPYEWYSPHPCA-QGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSG 623
Query: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
+W F L+++SSYTANLAA + + + + D +GT+ S+ + +
Sbjct: 624 VWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA---DQTAIEYGTIHGGSSMTFFQ 680
Query: 708 KSFPDMHAHMRRHS--------APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
S + M + +T G+A + + AF+++ ++ +Y +C
Sbjct: 681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSN---YAFLLESTMNEY--YRQRNC 735
Query: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
L +G +GYGIG+P S I + + + +++L KW++ C K
Sbjct: 736 NLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDH 795
Query: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGE 852
+ L M + G+FV+L GL A+ ++ E
Sbjct: 796 RAKGLGME--NIGGIFVVLICGLIVAIFMAMLE 826
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 147 bits (370), Expect = 7e-35
Identities = 111/410 (27%), Positives = 197/410 (48%), Gaps = 33/410 (8%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536
G+ ID+L+ L+ F++E+Y+ D KYG+ + DG W GLVG+L+ RA + +++ +I
Sbjct: 469 GFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITP 528
Query: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYE 596
R VVDFT+ + S+G+++R + + A + P S W + + L L + +
Sbjct: 529 DRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN 588
Query: 597 WRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLV 656
W +P L +T++ +++ Y ++ T R++M W +F L+V
Sbjct: 589 WLNPPRLQMGSMTSTTLY---NSMWFVYGSFVQQGGEVPYTTLAT-RMMMGAWWLFALIV 644
Query: 657 LSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK------SF 710
+SSYTANLAA + + + + D +GTV +S+ +++
Sbjct: 645 ISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIPYGTVLDSAVYEHVRMKGLNPFER 701
Query: 711 PDMHAHMRR--HSAPTTPRGVAMLTSDPPKLN----AFIMDKSLLDYEVSIDADCKLLTV 764
M++ M R + + + V + K+ AF+ D ++L+Y D DC T+
Sbjct: 702 DSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTI 761
Query: 765 GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY-KMVPCGKRVFAVTET 823
G A GYGI L SP S+ I + +G +D+L KW+ K C +++ +T
Sbjct: 762 GNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCD--LYSSVDT 819
Query: 824 LQ----MSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRL 869
Q + I FAG+F +L G+ + ++ E + + RKGSR+
Sbjct: 820 KQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNK------RKGSRV 863
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 144 bits (363), Expect = 4e-34
Identities = 149/582 (25%), Positives = 245/582 (42%), Gaps = 76/582 (13%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536
G+C+D+L LAE F + L LV DG YGA +G WTG+VG+L+ +A +AV +F+I +
Sbjct: 445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITA 504
Query: 537 ARSQVVDFTSPFFSTSLGIMVRAR--------DTASPIGAFMWPLHWSTWLGVFAALHLT 588
R +V+DF+ PF + + I+ R P +W +L V L L
Sbjct: 505 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLA 564
Query: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKCPTGRLLMN 647
A L+ YEW +P+ R R Y+ +L + + F + S P+ + R +
Sbjct: 565 AR-LSPYEWYNPHPCL-RARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSG 622
Query: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
+W F L+++SSYTANLAA + + + D +GT+ S + +
Sbjct: 623 VWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGTIHAGSTMTFFQ 679
Query: 708 KSFPDMHAHMRRHS--------APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
S + M + +T G+A + + AF+++ ++ +Y + +C
Sbjct: 680 NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLN---SRYAFLLESTMNEYHRRL--NC 734
Query: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
L +G +GYGIG+P SP ++ I + + + +++L KW++ C K
Sbjct: 735 NLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDH 794
Query: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKI 879
+ L M + G+F++L GL A+ ++ E F + R + + Q++
Sbjct: 795 RAKGLGME--NIGGIFIVLICGLIIAVFVAVME---FIWSTRRSAESEEVSVCQEMLQEL 849
Query: 880 HRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLE 939
A++ S+ P GP RA ++ R +R L
Sbjct: 850 RHAVSCRKTSRSRR---RRRPGGP------------------SRALLSLRAVREMR--LS 886
Query: 940 PAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQ 999
+ + A +A +A GP L PP+ AP P + V +E
Sbjct: 887 NGKLYSAGAGGDAGSA-HGGPQRLLDDPGPPSGARPAAPTPC------THVRVCQE---- 935
Query: 1000 ALVRRGQLLAQLGDSARHRPRRLLQARAAPAEA-PPHSGRPG 1040
RR Q L G A PR L PAEA P RPG
Sbjct: 936 --CRRIQALRASGAGA--PPRGL----GVPAEATSPPRPRPG 969
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 140 bits (354), Expect = 5e-33
Identities = 106/402 (26%), Positives = 187/402 (46%), Gaps = 51/402 (12%)
Query: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYG-ALRDGRWTGLVGDLLAGRAHMAVTSFSINS 536
G+ ID+L+ LA+ F +E+Y DG+YG L + W G++G+L++ RA +A+++ +I
Sbjct: 465 GFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITP 524
Query: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYE 596
R VVDF+ + S+GI+++ + I + P ++ W + AA+ + + + V
Sbjct: 525 ERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584
Query: 597 ----WRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIF 652
R+ PR +T+ SA+ + Y ++ S R++M W +F
Sbjct: 585 RIQAVRAQSAAQPRPSASATL---HSAIWIVYGAFVQQGGESSVNSMAM-RIVMGSWWLF 640
Query: 653 CLLVLSSYTANLAAVMVGD------KTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYI 706
L+V SSYTANLAA + +TF++LS +GTV +S+ Y
Sbjct: 641 TLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS---------KQVEMSYGTVRDSAVYEYF 691
Query: 707 K----------KSFPDMHAHMRRHSAPTTPRGVAMLTSDPPK--------LNAFIMDKSL 748
+ +F ++ + ++ G S P + AF+ D ++
Sbjct: 692 RAKGTNPLEQDSTFAELWRTISKNG------GADNCVSSPSEGIRKAKKGNYAFLWDVAV 745
Query: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 808
++Y D DC + +G + +GYGI L SP S+ I + +G +D+L KW+
Sbjct: 746 VEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWW 805
Query: 809 -KMVPCG--KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALL 847
M C A + + ++ FAG+F +L +GL A L
Sbjct: 806 PHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACL 847
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 39.7 bits (91), Expect = 0.015
Identities = 33/99 (33%), Positives = 43/99 (43%), Gaps = 6/99 (6%)
Query: 940 PAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQPGE--LQELERRIEVARERL 997
PAV + E AAPR+GP + RPPAARP+ +P E R+ V
Sbjct: 2034 PAVFLCSSRCEELRAAPRQGPA--PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAA 2091
Query: 998 RQALVRRGQLLAQLGDSARHRPRRLLQARAAPAEAPPHS 1036
R V+R L + S RP + A A A+A S
Sbjct: 2092 RPETVKRYASLPHI--SVARRPDGAVPAAPASADAARRS 2128
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,342,417
Number of Sequences: 37866
Number of extensions: 2553018
Number of successful extensions: 11415
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 10862
Number of HSP's gapped (non-prelim): 598
length of query: 1043
length of database: 18,247,518
effective HSP length: 112
effective length of query: 931
effective length of database: 14,006,526
effective search space: 13040075706
effective search space used: 13040075706
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.