Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 62548864
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo
sapiens]
(1344 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi... 2689 0.0
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like... 936 0.0
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like... 890 0.0
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 166 1e-40
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 112 2e-24
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 110 1e-23
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 110 1e-23
gi|94557295 mitogen-activated protein kinase 8 interacting prote... 102 2e-21
gi|94557297 mitogen-activated protein kinase 8 interacting prote... 102 2e-21
gi|229094128 active breakpoint cluster region-related protein i... 100 2e-20
gi|38679957 active breakpoint cluster region-related protein is... 100 2e-20
gi|38679954 active breakpoint cluster region-related protein is... 99 2e-20
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens] 99 2e-20
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens] 99 2e-20
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 89 2e-17
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 84 7e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 82 5e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 82 5e-15
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 80 1e-14
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 80 1e-14
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 78 5e-14
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 78 5e-14
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 77 1e-13
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 76 2e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 76 2e-13
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 76 2e-13
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 74 9e-13
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 70 1e-11
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens] 70 2e-11
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 69 2e-11
>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
Length = 1344
Score = 2689 bits (6970), Expect = 0.0
Identities = 1344/1344 (100%), Positives = 1344/1344 (100%)
Query: 1 MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEA 60
MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEA
Sbjct: 1 MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEA 60
Query: 61 PAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLH 120
PAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLH
Sbjct: 61 PAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLH 120
Query: 121 VPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEETPEVTEDRQPNSLSSEEPP 180
VPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEETPEVTEDRQPNSLSSEEPP
Sbjct: 121 VPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEETPEVTEDRQPNSLSSEEPP 180
Query: 181 TSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEG 240
TSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEG
Sbjct: 181 TSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEG 240
Query: 241 GNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDL 300
GNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDL
Sbjct: 241 GNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDL 300
Query: 301 MASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDH 360
MASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDH
Sbjct: 301 MASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDH 360
Query: 361 RSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILE 420
RSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILE
Sbjct: 361 RSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILE 420
Query: 421 QYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVAS 480
QYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVAS
Sbjct: 421 QYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVAS 480
Query: 481 FSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQ 540
FSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQ
Sbjct: 481 FSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQ 540
Query: 541 RFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI 600
RFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI
Sbjct: 541 RFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI 600
Query: 601 NERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD 660
NERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD
Sbjct: 601 NERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD 660
Query: 661 SRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMG 720
SRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMG
Sbjct: 661 SRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMG 720
Query: 721 PGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRA 780
PGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRA
Sbjct: 721 PGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRA 780
Query: 781 ADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCV 840
ADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCV
Sbjct: 781 ADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCV 840
Query: 841 EDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWI 900
EDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWI
Sbjct: 841 EDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWI 900
Query: 901 GSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRA 960
GSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRA
Sbjct: 901 GSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRA 960
Query: 961 SDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA 1020
SDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA
Sbjct: 961 SDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA 1020
Query: 1021 SYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAH 1080
SYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAH
Sbjct: 1021 SYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAH 1080
Query: 1081 QEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVT 1140
QEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVT
Sbjct: 1081 QEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVT 1140
Query: 1141 SLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKD 1200
SLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKD
Sbjct: 1141 SLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKD 1200
Query: 1201 KDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSS 1260
KDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSS
Sbjct: 1201 KDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSS 1260
Query: 1261 GSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR 1320
GSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR
Sbjct: 1261 GSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR 1320
Query: 1321 KARQPHQEELAPTVMVWQIPLLNI 1344
KARQPHQEELAPTVMVWQIPLLNI
Sbjct: 1321 KARQPHQEELAPTVMVWQIPLLNI 1344
>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 1 [Homo sapiens]
Length = 1279
Score = 936 bits (2419), Expect = 0.0
Identities = 535/1168 (45%), Positives = 730/1168 (62%), Gaps = 51/1168 (4%)
Query: 210 EEAIYDDVPRENSDSEPD----EMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSEC 265
E+ IYDDVP E+ D+ ++Y+D + + GWSSSEFESY E S E
Sbjct: 127 EDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAE-DLGWSSSEFESYSEDSGEEA 185
Query: 266 KNGIP--RSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQK 323
K + + R + + +LS DLTRLKE Y + RD++A VG ++Q+L+ K++ KM +
Sbjct: 186 KPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQ 245
Query: 324 LVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDV---DCKHPE 380
L+KAAK GTKDGLE+TR AV R SF+ K ++ EEE ++V D K P
Sbjct: 246 LMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDS-----EEEDMGLLEVSVSDIKPPA 300
Query: 381 AILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLK 440
L PMPEGLS QQVVRR+ILGS+V SE +YV++LKRIL+ Y PL EMEPK LS RK +
Sbjct: 301 PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360
Query: 441 TVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTA 500
VF+RVKEIL CHS+FQIAL+SRV+EWDS E IGD+FVASFSKSMVLD YS+YVNNF++A
Sbjct: 361 VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420
Query: 501 VAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGH 560
++++KK C TKPAFLEFLK+ Q SPDR TLY LM+KPIQRFPQFILLLQDMLKNT +GH
Sbjct: 421 MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480
Query: 561 PDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINER-YLNKLLSSGSRYLIRS 619
PDRL LQ+ALTELETLAEKLNE+KR ADQ E++Q+ K++++R LNKLL+SG R L+
Sbjct: 481 PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540
Query: 620 DDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSH-------DSRVMSSQRYLLK 672
+ + ETVY DRG+++K+KERRVF+LND+L+CA ++ +P++ S V +Y++K
Sbjct: 541 ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600
Query: 673 WSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLL 732
W+ L V +E G GT + L H A + NKVY+GP +L+Q+LQ+L
Sbjct: 601 WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660
Query: 733 HDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPG 792
DL V+ QIT LI L G YQNLN +VA DW LQRL+ KE+EI +A+ CR++L LPG
Sbjct: 661 KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720
Query: 793 KQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKH 852
K DKSGRP F VF T P K SWVN L +AK+ L EEN GW C ++D
Sbjct: 721 KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780
Query: 853 PLLVGHMPVMVAKQQEFKIECAAYNPE--PYLNNESQPDSFSTAHGFLWIGSCTHQM-GQ 909
P+L +P ++ ++ ++P P L + S S G+LW+G GQ
Sbjct: 781 PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAV--STSLPQGYLWVGGGQEGAGGQ 838
Query: 910 IAIVSFQNSTPKVIECFNVESRILCMLYVP-VEEKRREPGAPPDPETPAVRASDVPTICV 968
+ I S +P+ ++ F + + +LCM Y+P +EE+ P P+ A+ PTIC+
Sbjct: 839 VEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS--ATVHPTICL 896
Query: 969 GTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDG 1028
G ++GSI +Y S + L +P V+ L + L AGL +G +A+Y R G
Sbjct: 897 GLQDGSILLYSSVDTGTQC-LVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGG 955
Query: 1029 -SWDSE-PQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMV 1086
WD E P + +G PVR+LL +ED +WA+ G +V ++ T + EAHQ+E +
Sbjct: 956 VLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015
Query: 1087 ISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCH 1146
++HM +G G+W+AF+SG+++RLFHTETL+HLQ+INIAT +LPG + L VTSLL+C
Sbjct: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQ 1075
Query: 1147 GLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRD 1206
GLL VGT GV+V LPVPRL+GIPK+TG+GMVS + H PV F+ +AT++ D +S
Sbjct: 1076 GLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQ 1135
Query: 1207 SLAPGPEPQDEDQKDA-----LPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSG 1261
A GP +ED+ D +P G L++ I L L S S
Sbjct: 1136 EEAEGPR-AEEDKPDGQAHEPMPDSHVGRELTR---KKGILLQYRLRSTAHLPGPLLSMR 1191
Query: 1262 SLSLSHGSSSLEHRSEDSTIYDLLKDP---VSLRSKARRAKKAKASSALVVCGGQGHRR- 1317
+ + G ++LEH ED +IY++ DP V R AR A + + S ++ GGQG+R
Sbjct: 1192 EPAPADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNF 1250
Query: 1318 ---VHRKARQPHQEELAPTVMVWQIPLL 1342
+ RQ E T+++WQ+PL+
Sbjct: 1251 GSALGSSGRQAPCGETDSTLLIWQVPLM 1278
>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 2 [Homo sapiens]
Length = 1240
Score = 890 bits (2301), Expect = 0.0
Identities = 519/1166 (44%), Positives = 703/1166 (60%), Gaps = 86/1166 (7%)
Query: 210 EEAIYDDVPRENSDSEPD----EMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSEC 265
E+ IYDDVP E+ D+ ++Y+D + + GWSSSEFESY E S E
Sbjct: 127 EDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAE-DLGWSSSEFESYSEDSGEEA 185
Query: 266 KNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLV 325
K + VE + R + KM +L+
Sbjct: 186 KPEVE-------------------------------------VEPAKHRVSFQPKMTQLM 208
Query: 326 KAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDV---DCKHPEAI 382
KAAK GTKDGLE+TR AV R SF+ K ++ EEE ++V D K P
Sbjct: 209 KAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDS-----EEEDMGLLEVSVSDIKPPAPE 263
Query: 383 LTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTV 442
L PMPEGLS QQVVRR+ILGS+V SE +YV++LKRIL+ Y PL EMEPK LS RK + V
Sbjct: 264 LGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVV 323
Query: 443 FYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVA 502
F+RVKEIL CHS+FQIAL+SRV+EWDS E IGD+FVASFSKSMVLD YS+YVNNF++A++
Sbjct: 324 FFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMS 383
Query: 503 VLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPD 562
++KK C TKPAFLEFLK+ Q SPDR TLY LM+KPIQRFPQFILLLQDMLKNT +GHPD
Sbjct: 384 IIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPD 443
Query: 563 RLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINER-YLNKLLSSGSRYLIRSDD 621
RL LQ+ALTELETLAEKLNE+KR ADQ E++Q+ K++++R LNKLL+SG R L+ +
Sbjct: 444 RLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCET 503
Query: 622 MIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSH-------DSRVMSSQRYLLKWS 674
+ ETVY DRG+++K+KERRVF+LND+L+CA ++ +P++ S V +Y++KW+
Sbjct: 504 LTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWN 563
Query: 675 VPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHD 734
L V +E G GT + L H A + NKVY+GP +L+Q+LQ+L D
Sbjct: 564 TALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKD 623
Query: 735 LNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQ 794
L V+ QIT LI L G YQNLN +VA DW LQRL+ KE+EI +A+ CR++L LPGK
Sbjct: 624 LAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKP 683
Query: 795 DKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPL 854
DKSGRP F VF T P K SWVN L +AK+ L EEN GW C ++D P+
Sbjct: 684 DKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPI 743
Query: 855 LVGHMPVMVAKQQEFKIECAAYNPE--PYLNNESQPDSFSTAHGFLWIGSCTHQM-GQIA 911
L +P ++ ++ ++P P L + S S G+LW+G GQ+
Sbjct: 744 LACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAV--STSLPQGYLWVGGGQEGAGGQVE 801
Query: 912 IVSFQNSTPKVIECFNVESRILCMLYVP-VEEKRREPGAPPDPETPAVRASDVPTICVGT 970
I S +P+ ++ F + + +LCM Y+P +EE+ P P+ A+ PTIC+G
Sbjct: 802 IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS--ATVHPTICLGL 859
Query: 971 EEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDG-S 1029
++GSI +Y S + L +P V+ L + L AGL +G +A+Y R G
Sbjct: 860 QDGSILLYSSVDTGTQC-LVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVL 918
Query: 1030 WDSE-PQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVIS 1088
WD E P + +G PVR+LL +ED +WA+ G +V ++ T + EAHQ+E + ++
Sbjct: 919 WDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVT 978
Query: 1089 HMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGL 1148
HM +G G+W+AF+SG+++RLFHTETL+HLQ+INIAT +LPG + L VTSLL+C GL
Sbjct: 979 HMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGL 1038
Query: 1149 LMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSL 1208
L VGT GV+V LPVPRL+GIPK+TG+GMVS + H PV F+ +AT++ D +S
Sbjct: 1039 LWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEE 1098
Query: 1209 APGPEPQDEDQKDA-----LPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSL 1263
A GP +ED+ D +P G L++ I L L S S
Sbjct: 1099 AEGPR-AEEDKPDGQAHEPMPDSHVGRELTR---KKGILLQYRLRSTAHLPGPLLSMREP 1154
Query: 1264 SLSHGSSSLEHRSEDSTIYDLLKDP---VSLRSKARRAKKAKASSALVVCGGQGHRR--- 1317
+ + G ++LEH ED +IY++ DP V R AR A + + S ++ GGQG+R
Sbjct: 1155 APADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGS 1213
Query: 1318 -VHRKARQPHQEELAPTVMVWQIPLL 1342
+ RQ E T+++WQ+PL+
Sbjct: 1214 ALGSSGRQAPCGETDSTLLIWQVPLM 1239
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 166 bits (421), Expect = 1e-40
Identities = 146/609 (23%), Positives = 288/609 (47%), Gaps = 88/609 (14%)
Query: 375 DCKHPEAIL-----TPMPEGLSQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSE 428
+ K PEA TP + S+ QV +R+++ +++D+E++YV++L+ +++ Y +PL +
Sbjct: 1039 EAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ 1098
Query: 429 MEPKVLSERKL-KTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVL 487
E VL + L +F ++ E+L+ H F + + W + + +G + V SFSK +++
Sbjct: 1099 PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLV 1158
Query: 488 DAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFIL 547
+ YS Y++NF A ++ +PAFL+FL+Q + ++ L LM+KP+QR P++ L
Sbjct: 1159 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYEL 1218
Query: 548 LLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNK 607
L++D+LK+T + HPD L A ++ +AE++N+ R A++ ++ + I E ++
Sbjct: 1219 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEG 1277
Query: 608 L--LSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR--- 662
+ L + R +R + +IE I K+R +F+ D+++C T+ + R
Sbjct: 1278 MEDLQAPLRRFLRQEMVIEV-----KAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSM 1332
Query: 663 --------VMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKP 714
+ ++ +Y + W +PL D I+ S A E+
Sbjct: 1333 SLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNREN-------------------- 1372
Query: 715 NKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKK 774
+ + + L DL +GQ+++L +L +Q+L+ ++ D ++ + R + +K
Sbjct: 1373 ---------IQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDAL-RDLSAAMHRDLSEK 1422
Query: 775 EDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENH 834
+ A +L+L + + G ++ +F P + + + AK L
Sbjct: 1423 QALCYALSFPPTKLELCATRPE-GTDSY---IFEFPHPDARLGFEQAFDEAKRKLASSKS 1478
Query: 835 MGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTA 894
C++ P + +P+M + + CAA P LN+ +P
Sbjct: 1479 ----CLD-----------PEFLKAIPIMKTR-SGMQFSCAA----PTLNSCPEPSP---- 1514
Query: 895 HGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNV-ESRILCMLYVPVEEKRREPGAPPDP 953
+W+ + +GQ+ ++S + + P V C V +RILC+ VP + R PP
Sbjct: 1515 --EVWVCNSDGYVGQVCLLSLR-AEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSL 1571
Query: 954 ETPAVRASD 962
+P A +
Sbjct: 1572 RSPPETAPE 1580
Score = 110 bits (274), Expect = 1e-23
Identities = 75/283 (26%), Positives = 130/283 (45%), Gaps = 39/283 (13%)
Query: 965 TICVGTEEGSISIYKSSQGSK----KVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA 1020
++ +GTE+G + +Y+SS + ++LQH ++V + + ++ L NG +
Sbjct: 1740 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQH-----AASVTCILYLNNQVFVSLANGELV 1794
Query: 1021 SYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLE 1078
Y R WD + K + LG P+ ++ + LW +V ++S +T +E
Sbjct: 1795 VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFY 1854
Query: 1079 AHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQR-- 1136
Q+ ++ M S +G+W+ + + L+H +T + L ++++ PVH ML G
Sbjct: 1855 VGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAII 1914
Query: 1137 -------LSVTSLLVCHGLLMVGTSLGVLVALPV-------PRLQGIPKVTGRGMVSYHA 1182
L +T+LLVC LL VGTS GV++ +P PR P G+G
Sbjct: 1915 RQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQG------ 1968
Query: 1183 HNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPS 1225
H V+F+ A L + + L P P P + + LPS
Sbjct: 1969 HTGHVRFLA-AVQLPD-----GFNLLCPTPPPPPDTGPEKLPS 2005
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 112 bits (280), Expect = 2e-24
Identities = 83/283 (29%), Positives = 141/283 (49%), Gaps = 21/283 (7%)
Query: 376 CKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPK--- 432
C TP+P +Q R + + +E NYV+ L I++ ++ PL E +
Sbjct: 405 CTKSSKSSTPVPS----KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGP 460
Query: 433 VLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSE 492
+L+ ++KT+F + +I H+ + L + WD + IGD+F+ +SK +V Y
Sbjct: 461 ILAPEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPP 518
Query: 493 YVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQ 550
+VN F + + K KP F FLK Q A P+ R +L L+++P+QR P LLL
Sbjct: 519 FVNFFEMSKETIIKCEKQKPRFHAFLKINQ-AKPECGRQSLVELLIRPVQRLPSVALLLN 577
Query: 551 DMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLS 610
D+ K+T+ +PD+ L+ A+ L+ + +NE KR + + ++ + ++ N L
Sbjct: 578 DLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPAN--LL 635
Query: 611 SGSRYLIRSDDMIETVYN--DRGEIVKTKERRVFMLNDVLMCA 651
S R L++ + I + DRGE V +F+ ND L A
Sbjct: 636 SSHRSLVQRVETISLGEHPCDRGEQV-----TLFLFNDCLEIA 673
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 110 bits (274), Expect = 1e-23
Identities = 78/291 (26%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 396 VRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERKLKTVFYRVKEILQCH 453
+R+++L ++ SE+ Y+ L+ +L + K + VL+ ++++T+F++V E+ + H
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
Query: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
F L RV +W + +GD+F S+ L Y +V+N+ A+ + +K C
Sbjct: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQ 614
Query: 514 FLEFLK----QEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566
F E + + + + D TT L +L+ KP+ R + L+L D+LK+T HPD L
Sbjct: 615 FAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674
Query: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626
Q AL + +NE Q VK+ R L++ M+E V
Sbjct: 675 QDALRISQNFLSSINEEITPRRQSMTVKK---------------GEHRQLLKDSFMVELV 719
Query: 627 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPL 677
R K R VF+ D+L+C + + +Q+Y KW +PL
Sbjct: 720 EGAR------KLRHVFLFTDLLLCTKLKKQSGG-----KTQQYDCKWYIPL 759
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 110 bits (274), Expect = 1e-23
Identities = 78/291 (26%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 396 VRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERKLKTVFYRVKEILQCH 453
+R+++L ++ SE+ Y+ L+ +L + K + VL+ ++++T+F++V E+ + H
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
Query: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
F L RV +W + +GD+F S+ L Y +V+N+ A+ + +K C
Sbjct: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQ 614
Query: 514 FLEFLK----QEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566
F E + + + + D TT L +L+ KP+ R + L+L D+LK+T HPD L
Sbjct: 615 FAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674
Query: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626
Q AL + +NE Q VK+ R L++ M+E V
Sbjct: 675 QDALRISQNFLSSINEEITPRRQSMTVKK---------------GEHRQLLKDSFMVELV 719
Query: 627 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPL 677
R K R VF+ D+L+C + + +Q+Y KW +PL
Sbjct: 720 EGAR------KLRHVFLFTDLLLCTKLKKQSGG-----KTQQYDCKWYIPL 759
>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
isoform 2 [Homo sapiens]
Length = 1330
Score = 102 bits (254), Expect = 2e-21
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 17/227 (7%)
Query: 947 PGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMS 1002
P P + +S PT+ +G + G + ++ + KK ++L K +V+S
Sbjct: 946 PEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKL-------KDSVLS 998
Query: 1003 LACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASG 1060
L + L +G +A + R DG WD ++ LG +R + ++ D +W
Sbjct: 999 LVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYK 1058
Query: 1061 GQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQD 1120
+V +I +T +E +AH + +A G G+W++ STLRL+H T +HLQD
Sbjct: 1059 NKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQD 1118
Query: 1121 INIATPVHNMLP----GHQRLSVTSLLVCHGLLMVGTSLGVLVALPV 1163
++I V ML G + +T+LLV L VGT GV++++P+
Sbjct: 1119 VDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1165
>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
isoform 1 [Homo sapiens]
Length = 1336
Score = 102 bits (254), Expect = 2e-21
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 17/227 (7%)
Query: 947 PGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMS 1002
P P + +S PT+ +G + G + ++ + KK ++L K +V+S
Sbjct: 952 PEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKL-------KDSVLS 1004
Query: 1003 LACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASG 1060
L + L +G +A + R DG WD ++ LG +R + ++ D +W
Sbjct: 1005 LVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYK 1064
Query: 1061 GQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQD 1120
+V +I +T +E +AH + +A G G+W++ STLRL+H T +HLQD
Sbjct: 1065 NKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQD 1124
Query: 1121 INIATPVHNMLP----GHQRLSVTSLLVCHGLLMVGTSLGVLVALPV 1163
++I V ML G + +T+LLV L VGT GV++++P+
Sbjct: 1125 VDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1171
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 99.8 bits (247), Expect = 2e-20
Identities = 80/306 (26%), Positives = 141/306 (46%), Gaps = 44/306 (14%)
Query: 387 PEGLS------QQQVVRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERK 438
PEGL+ + +R+ +L + SE+ Y++ L+ +L + K + VL+ ++
Sbjct: 30 PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQ 89
Query: 439 LKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFS 498
++T+FY++++I + H F L +V +WDS +G +F S+ L Y +V+N+
Sbjct: 90 IETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYK 146
Query: 499 TAVAVLKKTCATKPAFLEFLKQ-------EQEASPDRTTLYSLMMKPIQRFPQFILLLQD 551
A+ +K + F + ++ + + S T+ +L+ KPI R + L+L D
Sbjct: 147 VALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHD 206
Query: 552 MLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSS 611
+LK+T HPD LQ AL + +NE D D R K
Sbjct: 207 LLKHTPVDHPDYPLLQDALRISQNFLSSINE---DIDPRRTAVTTPK------------G 251
Query: 612 GSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLL 671
+R L++ ++E + R K R VF+ DVL+CA + + Q+Y
Sbjct: 252 ETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKK-----TSAGKHQQYDC 300
Query: 672 KWSVPL 677
KW +PL
Sbjct: 301 KWYIPL 306
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 99.8 bits (247), Expect = 2e-20
Identities = 80/306 (26%), Positives = 141/306 (46%), Gaps = 44/306 (14%)
Query: 387 PEGLS------QQQVVRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERK 438
PEGL+ + +R+ +L + SE+ Y++ L+ +L + K + VL+ ++
Sbjct: 76 PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQ 135
Query: 439 LKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFS 498
++T+FY++++I + H F L +V +WDS +G +F S+ L Y +V+N+
Sbjct: 136 IETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYK 192
Query: 499 TAVAVLKKTCATKPAFLEFLKQ-------EQEASPDRTTLYSLMMKPIQRFPQFILLLQD 551
A+ +K + F + ++ + + S T+ +L+ KPI R + L+L D
Sbjct: 193 VALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHD 252
Query: 552 MLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSS 611
+LK+T HPD LQ AL + +NE D D R K
Sbjct: 253 LLKHTPVDHPDYPLLQDALRISQNFLSSINE---DIDPRRTAVTTPK------------G 297
Query: 612 GSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLL 671
+R L++ ++E + R K R VF+ DVL+CA + + Q+Y
Sbjct: 298 ETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKK-----TSAGKHQQYDC 346
Query: 672 KWSVPL 677
KW +PL
Sbjct: 347 KWYIPL 352
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 99.4 bits (246), Expect = 2e-20
Identities = 76/291 (26%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 396 VRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERKLKTVFYRVKEILQCH 453
+R+ +L + SE+ Y++ L+ +L + K + VL+ ++++T+FY++++I + H
Sbjct: 54 MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIH 113
Query: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
F L +V +WDS +G +F S+ L Y +V+N+ A+ +K +
Sbjct: 114 KEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCSQSNNQ 170
Query: 514 FLEFLKQ-------EQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566
F + ++ + + S T+ +L+ KPI R + L+L D+LK+T HPD L
Sbjct: 171 FQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLL 230
Query: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626
Q AL + +NE D D R K +R L++ ++E
Sbjct: 231 QDALRISQNFLSSINE---DIDPRRTAVTTPK------------GETRQLVKDGFLVEVS 275
Query: 627 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPL 677
+ R K R VF+ DVL+CA + + Q+Y KW +PL
Sbjct: 276 ESSR------KLRHVFLFTDVLLCAKLKK-----TSAGKHQQYDCKWYIPL 315
>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
Length = 1321
Score = 99.4 bits (246), Expect = 2e-20
Identities = 67/272 (24%), Positives = 124/272 (45%), Gaps = 47/272 (17%)
Query: 960 ASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMSLACTSQSLYAGLV 1015
+S +PT+ +G + G + ++ S +K ++L K +++S+ + L
Sbjct: 966 SSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKL-------KDSILSIVHVKGIVLVALA 1018
Query: 1016 NGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAV 1073
+G +A + R DG WD ++ LG +R + ++ D +W +++++ + +
Sbjct: 1019 DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078
Query: 1074 EGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLP- 1132
E +AH + + +A G G+W++ STLRL+H T +HLQD++I V ML
Sbjct: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138
Query: 1133 ---GHQRLSVTSLLVCHGLLMVGTSLGVLVALPVP---RLQGIP---------------- 1170
G + +T+L+V L VGT GV++++P+ + G+P
Sbjct: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS 1198
Query: 1171 -KVT----------GRGMVSYHAHNSPVKFIV 1191
KVT + +H H VKF V
Sbjct: 1199 DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFV 1230
>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
Length = 1307
Score = 99.4 bits (246), Expect = 2e-20
Identities = 67/272 (24%), Positives = 124/272 (45%), Gaps = 47/272 (17%)
Query: 960 ASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMSLACTSQSLYAGLV 1015
+S +PT+ +G + G + ++ S +K ++L K +++S+ + L
Sbjct: 952 SSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKL-------KDSILSIVHVKGIVLVALA 1004
Query: 1016 NGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAV 1073
+G +A + R DG WD ++ LG +R + ++ D +W +++++ + +
Sbjct: 1005 DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064
Query: 1074 EGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLP- 1132
E +AH + + +A G G+W++ STLRL+H T +HLQD++I V ML
Sbjct: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124
Query: 1133 ---GHQRLSVTSLLVCHGLLMVGTSLGVLVALPVP---RLQGIP---------------- 1170
G + +T+L+V L VGT GV++++P+ + G+P
Sbjct: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS 1184
Query: 1171 -KVT----------GRGMVSYHAHNSPVKFIV 1191
KVT + +H H VKF V
Sbjct: 1185 DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFV 1216
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 89.4 bits (220), Expect = 2e-17
Identities = 69/269 (25%), Positives = 132/269 (49%), Gaps = 24/269 (8%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLF 456
R+ + ++ +E+NYV+ L+ + E ++KPL ME ++L+E+++ +F KE++ C+
Sbjct: 1238 RQGYIHELIVTEENYVNDLQLVTEIFQKPL--MESELLTEKEVAMIFVNWKELIMCNIKL 1295
Query: 457 QIALASRVS---EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
AL R E V+MIGD+ A + Y + + A++++ P
Sbjct: 1296 LKALRVRKKMSGEKMPVKMIGDILSAQLPH---MQPYIRFCSRQLNGAALIQQKTDEAPD 1352
Query: 514 FLEFLKQ-EQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTE 572
F EF+K+ + L S ++KP+QR ++ L+++++L+NT + HPD L+ AL +
Sbjct: 1353 FKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEK 1412
Query: 573 LETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLL-------SSGSRYLIRSDDMIET 625
E L ++NE R+ + ++ I + L++ L G R + S + +
Sbjct: 1413 AEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKA 1472
Query: 626 VYNDRGEIVKTKERRVFMLNDVLMCATVS 654
N KE F+ ND L+ ++
Sbjct: 1473 KSN--------KELYGFLFNDFLLLTQIT 1493
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 84.3 bits (207), Expect = 7e-16
Identities = 68/265 (25%), Positives = 118/265 (44%), Gaps = 29/265 (10%)
Query: 399 YILGSVVDSEKNYVDALKRILEQYEKPLS----EMEPKVLSERKLKTVFYRVKEILQCHS 454
+I ++ SEK +VD LK + + ++ ++ V+ +R L + Y + ++ + +
Sbjct: 874 HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNR 933
Query: 455 LFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAF 514
L R+ W + I D+FV K L YS Y+ F +A+L + C P F
Sbjct: 934 DLLKELEERMLHWTEQQRIADIFV---KKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGF 990
Query: 515 LEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTE 572
++ E E SP L ++KP+QR PQ+ LLL D LKN + D Q AL
Sbjct: 991 AAVVR-EFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 1049
Query: 573 LETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGE 632
+ +A N+ + D ++ QI ++N + +++ G V+ G
Sbjct: 1050 VIEVANHANDTMKQGDNFQKLMQIQYSLNGHH--EIVQPG------------RVFLKEGI 1095
Query: 633 IVK-----TKERRVFMLNDVLMCAT 652
++K + R F+ ND L+ T
Sbjct: 1096 LMKLSRKVMQPRMFFLFNDALLYTT 1120
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/266 (26%), Positives = 131/266 (49%), Gaps = 28/266 (10%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLF 456
R+ + ++ +E+ Y+ L+ ++E ++K ++E L+E ++ +F KE++ ++
Sbjct: 1183 RQGYIHELIQTEERYMADLQLVVEVFQKRMAESG--FLTEGEMALIFVNWKELIMSNTKL 1240
Query: 457 QIALASRVS---EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
AL R E V+MIGD+ A S + AY + + A+L++
Sbjct: 1241 LKALRVRKKTGGEKMPVQMIGDILAAELSH---MQAYIRFCSCQLNGAALLQQKTDEDTD 1297
Query: 514 FLEFLKQEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMAL 570
F EFLK+ AS R L S ++KP+QR ++ LL++ +L+NT + H D L++AL
Sbjct: 1298 FKEFLKKL--ASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLAL 1355
Query: 571 TELETLAEKLNERKRDADQRCEVKQI-----AKAINERYLNKLLSS--GSRYLIRSDDMI 623
E L ++NE R+ + ++ I + + E+ + L++ G R L+ S +
Sbjct: 1356 ERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLY 1415
Query: 624 ETVYNDRGEIVKTKERRVFMLNDVLM 649
+T N KE F+ ND L+
Sbjct: 1416 KTKSN--------KELHGFLFNDFLL 1433
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/266 (26%), Positives = 131/266 (49%), Gaps = 28/266 (10%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLF 456
R+ + ++ +E+ Y+ L+ ++E ++K ++E L+E ++ +F KE++ ++
Sbjct: 1210 RQGYIHELIQTEERYMADLQLVVEVFQKRMAESG--FLTEGEMALIFVNWKELIMSNTKL 1267
Query: 457 QIALASRVS---EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
AL R E V+MIGD+ A S + AY + + A+L++
Sbjct: 1268 LKALRVRKKTGGEKMPVQMIGDILAAELSH---MQAYIRFCSCQLNGAALLQQKTDEDTD 1324
Query: 514 FLEFLKQEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMAL 570
F EFLK+ AS R L S ++KP+QR ++ LL++ +L+NT + H D L++AL
Sbjct: 1325 FKEFLKKL--ASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLAL 1382
Query: 571 TELETLAEKLNERKRDADQRCEVKQI-----AKAINERYLNKLLSS--GSRYLIRSDDMI 623
E L ++NE R+ + ++ I + + E+ + L++ G R L+ S +
Sbjct: 1383 ERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLY 1442
Query: 624 ETVYNDRGEIVKTKERRVFMLNDVLM 649
+T N KE F+ ND L+
Sbjct: 1443 KTKSN--------KELHGFLFNDFLL 1460
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 80.5 bits (197), Expect = 1e-14
Identities = 66/270 (24%), Positives = 125/270 (46%), Gaps = 19/270 (7%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLS---EMEPKVLSERKLKTVFYRVKEILQCH 453
R ++ ++ SE+ YV L+ + + Y PL +LS ++ +F + +IL +
Sbjct: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
Query: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513
F L R+ EW +G++ V F L+ Y+ + NN+ + ++K PA
Sbjct: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683
Query: 514 FLEFLKQEQEASPDRT-TLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTE 572
F FLK+ + + +L L++ P +RF +++ LL + +T H DR L A+ +
Sbjct: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
Query: 573 LETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGE 632
++ +++ K++ + + I + I + LS +RYLIR D+ + D
Sbjct: 744 IKKYKGYIDQMKQNITMKDHLSDIQRII---WGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
Query: 633 IVKTK------ERRVFMLNDVLMCATVSSR 656
+ + +F+ ND L+ VSSR
Sbjct: 801 SFSLRLYEHIHDLSLFLFNDALL---VSSR 827
>gi|38505170 Ras protein-specific guanine nucleotide-releasing
factor 2 [Homo sapiens]
Length = 1237
Score = 80.1 bits (196), Expect = 1e-14
Identities = 82/338 (24%), Positives = 154/338 (45%), Gaps = 45/338 (13%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPL----SEMEPKVLSERKLKTVFYRVKEILQC 452
R I+ ++V++E YV L ++ + +PL S +P + S + ++F + I+
Sbjct: 244 RNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPI-SHDDVSSIFLNSETIMFL 302
Query: 453 HSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKP 512
H +F L +R++ W ++ ++ D+F +L+ Y E+V N ++ VL C
Sbjct: 303 HEIFHQGLKARIANWPTL-ILADLFDILLP---MLNIYQEFVRNHQYSLQVL-ANCKQNR 357
Query: 513 AFLEFLKQEQEASP--DRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMAL 570
F + LKQ EA+P + L + + P+ + P++I+ L ++L +T H +R L+ A
Sbjct: 358 DFDKLLKQ-YEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAK 416
Query: 571 TELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDR 630
++LE L+ +++ D + + I + I E +L S+ IR +I+ +R
Sbjct: 417 SKLEELSRVMHDEVSDTENIRKNLAIERMIVEGC--DILLDTSQTFIRQGSLIQVPSVER 474
Query: 631 GEIVKTK----------ERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHV 680
G++ K + ER+ F+ + T SS + +LLK L +
Sbjct: 475 GKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSS---------GGKLHLLKTGGVLSLI 525
Query: 681 DA-------IEYGSSAGTGEHSRHL----AVHPPESLA 707
D S G+G+ HL V PP++ A
Sbjct: 526 DCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAA 563
>gi|224586880 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 3 [Homo sapiens]
Length = 1257
Score = 78.2 bits (191), Expect = 5e-14
Identities = 66/275 (24%), Positives = 133/275 (48%), Gaps = 25/275 (9%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPL----SEMEPKVLSERKLKTVFYRVKEILQC 452
R ++ S++++E YV L ++ + +PL S +P + + + ++F + I+
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHD-DVSSIFLNSETIMFL 299
Query: 453 HSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKP 512
H +F L +R+S W ++ ++ D+F +L+ Y E+V N ++ +L C
Sbjct: 300 HQIFYQGLKARISSWPTL-VLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CKQNR 354
Query: 513 AFLEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMAL 570
F + LK EA PD TL + + P+ + P++IL L ++L +T H +R L A
Sbjct: 355 DFDKLLK-HYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413
Query: 571 TELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDR 630
++LE L+ +++ + + + I + I E ++L S+ +R +I+ +++
Sbjct: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGC--EILLDTSQTFVRQGSLIQVPMSEK 471
Query: 631 GEIV----------KTKERRVFMLNDVLMCATVSS 655
G+I K ER+ F+ + L+ T S
Sbjct: 472 GKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506
>gi|24797099 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 1 [Homo sapiens]
Length = 1273
Score = 78.2 bits (191), Expect = 5e-14
Identities = 66/275 (24%), Positives = 133/275 (48%), Gaps = 25/275 (9%)
Query: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPL----SEMEPKVLSERKLKTVFYRVKEILQC 452
R ++ S++++E YV L ++ + +PL S +P + + + ++F + I+
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHD-DVSSIFLNSETIMFL 299
Query: 453 HSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKP 512
H +F L +R+S W ++ ++ D+F +L+ Y E+V N ++ +L C
Sbjct: 300 HQIFYQGLKARISSWPTL-VLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CKQNR 354
Query: 513 AFLEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMAL 570
F + LK EA PD TL + + P+ + P++IL L ++L +T H +R L A
Sbjct: 355 DFDKLLK-HYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413
Query: 571 TELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDR 630
++LE L+ +++ + + + I + I E ++L S+ +R +I+ +++
Sbjct: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGC--EILLDTSQTFVRQGSLIQVPMSEK 471
Query: 631 GEIV----------KTKERRVFMLNDVLMCATVSS 655
G+I K ER+ F+ + L+ T S
Sbjct: 472 GKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 76.6 bits (187), Expect = 1e-13
Identities = 66/265 (24%), Positives = 125/265 (47%), Gaps = 18/265 (6%)
Query: 391 SQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPL--SEMEPKVLSERKLKTVFYRVKE 448
S Q + I+ ++++E+ YV L + + + + L + K E ++ +F +
Sbjct: 97 SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISS 156
Query: 449 ILQCHSLFQIA-LASRVSEWDSVEMIGDVF--VASFSKSMVLDAYSEYVNNFSTAVAVLK 505
I Q HS F + L R+ +W + IGDV +A F K YSEYV NF A +L
Sbjct: 157 IYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKM-----YSEYVKNFERAAELLA 211
Query: 506 KTCATKPAFLEFLKQEQEASPDRT-TLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRL 564
P F E L + Q + + TL M++P+QR P++ LLL++ ++ PD+
Sbjct: 212 TWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQA 271
Query: 565 PLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIE 624
Q AL + + A+ N + ++ ++ ++ + + L + S L+R +++
Sbjct: 272 DAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLG---LEDDIVDPSNTLLREGPVLK 328
Query: 625 TVYNDRGEIVKTKERRVFMLNDVLM 649
+ + ER +F+ N++L+
Sbjct: 329 ISFRRNDPM----ERYLFLFNNMLL 349
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 76.3 bits (186), Expect = 2e-13
Identities = 60/217 (27%), Positives = 108/217 (49%), Gaps = 12/217 (5%)
Query: 392 QQQVVRRYILGSVVDSEKNYVDALKRI----LEQYEKPLSEMEPKVLSERKLKTVFYRVK 447
+Q +R +L ++ +E++YV L+ + L + + +++ K L+E +K +F ++
Sbjct: 45 RQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIE 104
Query: 448 EILQCHSLFQIALASRVS-EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKK 506
+IL+ H F AL + E S +G+VF+ K V Y EY +N A+ +L +
Sbjct: 105 DILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCV---YEEYCSNHEKALRLLVE 161
Query: 507 TCATKPAFLEFLKQEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDR 563
P FL +TT L ++ PIQR ++ LLL+++ K T HPD
Sbjct: 162 LNKI-PTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH 220
Query: 564 LPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI 600
+Q AL ++T+ +NE KR ++ ++Q+ I
Sbjct: 221 PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHI 257
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 76.3 bits (186), Expect = 2e-13
Identities = 63/266 (23%), Positives = 121/266 (45%), Gaps = 23/266 (8%)
Query: 388 EGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVK 447
E S + +R ++ ++ +E++Y+ L+ I E Y + + + SE +L+T+F ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334
Query: 448 EILQCHSLFQIALASRVS-EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKK 506
+I +C F AL R + E + +G F+ + + YSEY NN A L +
Sbjct: 335 DIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQI---YSEYCNNHPNACVELSR 391
Query: 507 TCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566
F +L ++ P+Q+ ++ L L ++LK T H D +
Sbjct: 392 LTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDV 451
Query: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626
+ AL ++ +A+ +NERKR + ++ Q +I + G L+RS ++I +
Sbjct: 452 EAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED-------WEGEDLLVRSSELIYS- 503
Query: 627 YNDRGEIVKT------KERRVFMLND 646
GE+ + ++R+F L D
Sbjct: 504 ----GELTRVTQPQAKSQQRMFFLFD 525
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 76.3 bits (186), Expect = 2e-13
Identities = 63/266 (23%), Positives = 121/266 (45%), Gaps = 23/266 (8%)
Query: 388 EGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVK 447
E S + +R ++ ++ +E++Y+ L+ I E Y + + + SE +L+T+F ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334
Query: 448 EILQCHSLFQIALASRVS-EWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKK 506
+I +C F AL R + E + +G F+ + + YSEY NN A L +
Sbjct: 335 DIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQI---YSEYCNNHPNACVELSR 391
Query: 507 TCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566
F +L ++ P+Q+ ++ L L ++LK T H D +
Sbjct: 392 LTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDV 451
Query: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626
+ AL ++ +A+ +NERKR + ++ Q +I + G L+RS ++I +
Sbjct: 452 EAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED-------WEGEDLLVRSSELIYS- 503
Query: 627 YNDRGEIVKT------KERRVFMLND 646
GE+ + ++R+F L D
Sbjct: 504 ----GELTRVTQPQAKSQQRMFFLFD 525
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 73.9 bits (180), Expect = 9e-13
Identities = 79/341 (23%), Positives = 151/341 (44%), Gaps = 16/341 (4%)
Query: 386 MPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKT---- 441
+ + +SQ++ R+ + V+ SE +Y+ +L+ ++ ++ K LS+ KT
Sbjct: 429 LSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNS------KELSDTMTKTERHH 482
Query: 442 VFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAV 501
+F + ++ + F I L +R ++ I D+ + + D Y +Y N
Sbjct: 483 LFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTF--DPYVKYCTNEVYQQ 540
Query: 502 AVLKKTCATKPAFLEFLKQ-EQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGH 560
L+K AT P+F E L + E + S ++ P+QR + LL+ + + T K
Sbjct: 541 RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS 600
Query: 561 PDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSD 620
P + AL E+ L NE R ++ + I + + L S SR+L++
Sbjct: 601 PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG 660
Query: 621 DMIETVYNDRGEIVKTKERRV--FMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLG 678
++ V + +T +++V F+ NDVL+ S S++ S + LL S
Sbjct: 661 ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE 720
Query: 679 HVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYM 719
+++ G ++ T +SR + +L V++N KV M
Sbjct: 721 ELNS-SPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEM 760
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 70.5 bits (171), Expect = 1e-11
Identities = 51/199 (25%), Positives = 104/199 (52%), Gaps = 10/199 (5%)
Query: 404 VVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASR 463
+V++E+ YV L+ I+E Y PL + LS ++ T+F +++I + F L
Sbjct: 110 IVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYE----FSSELLED 165
Query: 464 VSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQE 523
+ S I + FV +S D Y+ Y N+ +++A+L++ + PA L +L++ Q
Sbjct: 166 LENSSSAGGIAECFV---QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAAL-WLQERQA 221
Query: 524 ASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSK--GHPDRLPLQMALTELETLAEKLN 581
L S ++KP+QR ++ LLLQ++ K+ ++ G R ++ A+ + +A +N
Sbjct: 222 QLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYIN 281
Query: 582 ERKRDADQRCEVKQIAKAI 600
+ KR + ++++ + +
Sbjct: 282 DMKRKQEHAARLQEVQRRL 300
>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
Length = 1462
Score = 69.7 bits (169), Expect = 2e-11
Identities = 67/293 (22%), Positives = 126/293 (43%), Gaps = 24/293 (8%)
Query: 365 EEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYE- 423
+EEQ + D + +T EG S+ V+ + +L S EK YV+ L+ + +
Sbjct: 865 DEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSS----EKAYVEMLQHLNLDFHG 920
Query: 424 ---KPLSEMEPK---VLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVF 477
+ L +M+ + L+ +L+ + I H L R+S W+S + + DVF
Sbjct: 921 AVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVF 980
Query: 478 VASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQ-EQEASPDRTTLYSLMM 536
+A + D ++ ++ F + +L + C P +++ EQ T ++
Sbjct: 981 LA---REQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLL 1037
Query: 537 KPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQI 596
+ +QR Q+ +LL D L N + Q AL+ + + ++ N+ + ++ I
Sbjct: 1038 RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHI 1097
Query: 597 AKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLM 649
++ R LL G +L M T N R R +F++NDVL+
Sbjct: 1098 EHSV--RGQGDLLQPGREFLKEGTLMKVTGKNRR-------PRHLFLMNDVLL 1141
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 69.3 bits (168), Expect = 2e-11
Identities = 74/291 (25%), Positives = 144/291 (49%), Gaps = 35/291 (12%)
Query: 332 TKDGLERTRAAVKRG-RSFIRTKSLIAQDHRSSL---------EEEQNLFIDVDCKHPEA 381
T L RT A+ G R F +S+ +D L E+E++L+ DC + E
Sbjct: 111 TLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLY---DCVYGED 167
Query: 382 ILTPMPEGLSQQQV----------VRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEP 431
+ E L + + +R L + +E+ Y + L+ I + + PL
Sbjct: 168 EGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLK---- 223
Query: 432 KVLSERKLKTVFYRVKEILQCH-SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAY 490
+ L+ + +VF + E+++ H +L Q S V++ D + + VF+ ++ + +V+ Y
Sbjct: 224 RFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKND--QNLYQVFI-NYKERLVI--Y 278
Query: 491 SEYVNNFSTAVAVLKKTCATKPAF-LEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLL 549
+Y + +A++ L TK L+ + + A+ + TL L++ P+QR ++ LLL
Sbjct: 279 GQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLL 338
Query: 550 QDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI 600
Q+++K+T+ ++ L++AL ++ LA+ +NE KRD + E+KQ +I
Sbjct: 339 QELVKHTT-DPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSI 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,908,101
Number of Sequences: 37866
Number of extensions: 2827574
Number of successful extensions: 10937
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 9968
Number of HSP's gapped (non-prelim): 1045
length of query: 1344
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1230
effective length of database: 13,930,794
effective search space: 17134876620
effective search space used: 17134876620
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.