Guide to the Human Genome
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Search of human proteins with 62243586

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
         (565 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]            1159   0.0  
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]            1159   0.0  
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]   339   5e-93
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...   339   5e-93
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]            212   8e-55
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]            212   8e-55
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]            212   8e-55
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                  174   1e-43
gi|45267835 ubiquitin specific protease 50 [Homo sapiens]             140   4e-33
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                133   5e-31
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]           130   4e-30
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]            128   2e-29
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]    127   2e-29
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]    127   2e-29
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]        126   5e-29
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]                  124   2e-28
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]            124   3e-28
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]             120   4e-27
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]   118   2e-26
gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ...   118   2e-26
gi|22550104 ubiquitin specific protease 32 [Homo sapiens]             118   2e-26
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]             117   2e-26
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ...   117   3e-26
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap...   117   4e-26
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi...   117   4e-26
gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ...   117   4e-26
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ...   116   6e-26
gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo ...   116   6e-26
gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Ho...   115   1e-25
gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Ho...   115   1e-25

>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score = 1159 bits (2998), Expect = 0.0
 Identities = 565/565 (100%), Positives = 565/565 (100%)

Query: 1   MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
           MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
Sbjct: 1   MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60

Query: 61  ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
           ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
Sbjct: 61  ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120

Query: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
           PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
Sbjct: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180

Query: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
           GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
Sbjct: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240

Query: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
           LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
Sbjct: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300

Query: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
           DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
Sbjct: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360

Query: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
           RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
Sbjct: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420

Query: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
           NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
Sbjct: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480

Query: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
           DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
Sbjct: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540

Query: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
           SENQVASSEGYVLFYQLMQEPPRCL
Sbjct: 541 SENQVASSEGYVLFYQLMQEPPRCL 565


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score = 1159 bits (2998), Expect = 0.0
 Identities = 565/565 (100%), Positives = 565/565 (100%)

Query: 1   MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
           MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
Sbjct: 1   MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60

Query: 61  ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
           ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
Sbjct: 61  ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120

Query: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
           PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
Sbjct: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180

Query: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
           GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
Sbjct: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240

Query: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
           LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
Sbjct: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300

Query: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
           DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
Sbjct: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360

Query: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
           RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
Sbjct: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420

Query: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
           NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
Sbjct: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480

Query: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
           DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
Sbjct: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540

Query: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
           SENQVASSEGYVLFYQLMQEPPRCL
Sbjct: 541 SENQVASSEGYVLFYQLMQEPPRCL 565


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score =  339 bits (869), Expect = 5e-93
 Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
           G  GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++  G  A   L E FA +I  
Sbjct: 56  GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115

Query: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
           +W     + V+P+ F+   Q+Y P F GY+QQDAQEFL+ L++ LH E+NR         
Sbjct: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 166

Query: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
               V   P+     L+   L DD++   MW++YLEREDS+I DLFVGQLKS L C  CG
Sbjct: 167 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 220

Query: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
           Y ST F+ F DLSLPI K+G+   +V+L DC  LFTKE+ L+ +  P C RCR + R  K
Sbjct: 221 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 278

Query: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
           K ++QRFP+ILVLHL RFS SR    K +  V+FPL+ L L +FAS+     VY LYA+ 
Sbjct: 279 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 338

Query: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
           NHSG+   GHYTA CR   TG WH +NDS V+P+S +QV +S+ Y+LFY+L   P R
Sbjct: 339 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 395


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score =  339 bits (869), Expect = 5e-93
 Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
           G  GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++  G  A   L E FA +I  
Sbjct: 265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 324

Query: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
           +W     + V+P+ F+   Q+Y P F GY+QQDAQEFL+ L++ LH E+NR         
Sbjct: 325 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 375

Query: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
               V   P+     L+   L DD++   MW++YLEREDS+I DLFVGQLKS L C  CG
Sbjct: 376 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 429

Query: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
           Y ST F+ F DLSLPI K+G+   +V+L DC  LFTKE+ L+ +  P C RCR + R  K
Sbjct: 430 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 487

Query: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
           K ++QRFP+ILVLHL RFS SR    K +  V+FPL+ L L +FAS+     VY LYA+ 
Sbjct: 488 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 547

Query: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
           NHSG+   GHYTA CR   TG WH +NDS V+P+S +QV +S+ Y+LFY+L   P R
Sbjct: 548 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 604


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  212 bits (539), Expect = 8e-55
 Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)

Query: 208  GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
            G    GLRNLGNTC++N++LQCL +   L D+  R  ++ ++      G   E+ E F  
Sbjct: 773  GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832

Query: 265  VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
            ++ ALW       ++P  F+    K    F+GYSQQD+QE L  LM+ LH ++N+   R 
Sbjct: 833  IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891

Query: 325  PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
                 N                  L D   A   W+++ +  +S IV LF GQ KS ++C
Sbjct: 892  RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936

Query: 385  QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
              C  +S TFE F  LSLP+        K +L+DC  LF+KEE+L   N   C  CR + 
Sbjct: 937  LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992

Query: 445  RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
             S KK+ + + P +L++HL RFS      +K    VDFPL+ L L  +    K     Y 
Sbjct: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052

Query: 504  LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
            L+++ NH G +  GHYTA C+   +  W  ++D  VS +S + V SS  Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  212 bits (539), Expect = 8e-55
 Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)

Query: 208  GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
            G    GLRNLGNTC++N++LQCL +   L D+  R  ++ ++      G   E+ E F  
Sbjct: 773  GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832

Query: 265  VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
            ++ ALW       ++P  F+    K    F+GYSQQD+QE L  LM+ LH ++N+   R 
Sbjct: 833  IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891

Query: 325  PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
                 N                  L D   A   W+++ +  +S IV LF GQ KS ++C
Sbjct: 892  RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936

Query: 385  QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
              C  +S TFE F  LSLP+        K +L+DC  LF+KEE+L   N   C  CR + 
Sbjct: 937  LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992

Query: 445  RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
             S KK+ + + P +L++HL RFS      +K    VDFPL+ L L  +    K     Y 
Sbjct: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052

Query: 504  LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
            L+++ NH G +  GHYTA C+   +  W  ++D  VS +S + V SS  Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score =  212 bits (539), Expect = 8e-55
 Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)

Query: 208  GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
            G    GLRNLGNTC++N++LQCL +   L D+  R  ++ ++      G   E+ E F  
Sbjct: 773  GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832

Query: 265  VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
            ++ ALW       ++P  F+    K    F+GYSQQD+QE L  LM+ LH ++N+   R 
Sbjct: 833  IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891

Query: 325  PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
                 N                  L D   A   W+++ +  +S IV LF GQ KS ++C
Sbjct: 892  RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936

Query: 385  QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
              C  +S TFE F  LSLP+        K +L+DC  LF+KEE+L   N   C  CR + 
Sbjct: 937  LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992

Query: 445  RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
             S KK+ + + P +L++HL RFS      +K    VDFPL+ L L  +    K     Y 
Sbjct: 993  DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052

Query: 504  LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
            L+++ NH G +  GHYTA C+   +  W  ++D  VS +S + V SS  Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score =  174 bits (442), Expect = 1e-43
 Identities = 127/373 (34%), Positives = 175/373 (46%), Gaps = 54/373 (14%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCL-----------------RRDFRQEVPGGGRA 255
           GLRNLGNTCF+NA+LQ LS+   +  FC                  RR +     G    
Sbjct: 160 GLRNLGNTCFMNAILQSLSN---IEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNV 216

Query: 256 QELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHL 315
             L E F   + ALW   S  A +P     V  K +P+F GY QQDA EF++ L++ LHL
Sbjct: 217 S-LVEEFRKTLCALWQ-GSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL 274

Query: 316 EINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFV 375
           E+            NG       R   L E   LS  ++        +    + +  +F 
Sbjct: 275 ELQGG--------FNGV-----SRSAILQENSTLSASNKC------CINGASTVVTAIFG 315

Query: 376 GQLKSCLKCQACGYRSTTFEVFCDLSLPIPK-------KGFAGGKV-SLRDCFNLFTKEE 427
           G L++ + C  CG  S  F+ F DLSL IP        K    G V SLRDC   FT  E
Sbjct: 316 GILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLE 375

Query: 428 ELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRL 487
           EL+     +C +C++K +STKK  +Q+ P++L LHL RF  +     K    V+FPL+ L
Sbjct: 376 ELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGL 435

Query: 488 SLGDFASDKAGSP----VYQLYALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSE 542
            +  +  +   S     +Y L A+  H GS V  GHYTA    +  W  +NDS V+   E
Sbjct: 436 DMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDE 495

Query: 543 NQVASSEGYVLFY 555
             V  ++ Y+LFY
Sbjct: 496 ETVVKAKAYILFY 508


>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
          Length = 339

 Score =  140 bits (352), Expect = 4e-33
 Identities = 104/324 (32%), Positives = 147/324 (45%), Gaps = 41/324 (12%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDF---RQEVPGGGRAQELTEAFADVI 266
           G  GL NLGNTC +NA+ QCL S  PL ++ L   +    Q+        E+  AFA ++
Sbjct: 42  GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLM 101

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR--GRRA 324
             +W  DS + V+P  F +      P+F+   QQDAQEFL  ++  LH  + +    RR 
Sbjct: 102 TDMWLGDS-DCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRR- 159

Query: 325 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKS---C 381
                                  E     R    W   +  E S I  LF  QL     C
Sbjct: 160 --------------------RSYEKGSTQRCCRKW---ITTETSIITQLFEEQLNYSIVC 196

Query: 382 LKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCR 441
           LKC+ C Y++  F VF   SLPIP K     + SLRDC   F +++ L   N   C  C 
Sbjct: 197 LKCEKCTYKNEVFTVF---SLPIPSKY----ECSLRDCLQCFFQQDALTWNNEIHCSFCE 249

Query: 442 QKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSP 500
            K  +  + ++ + P+I++ HL RF     + +K    + +PL  L L  +  S     P
Sbjct: 250 TKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYP 309

Query: 501 VYQLYALCNHSGSVHYGHYTALCR 524
            Y L A+ NH G +  GHYTA C+
Sbjct: 310 KYNLCAVVNHFGDLDGGHYTAFCK 333


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score =  133 bits (334), Expect = 5e-31
 Identities = 106/381 (27%), Positives = 156/381 (40%), Gaps = 78/381 (20%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIGALW 270
           GL NLGNTCF+N ++Q L+ T  LRDF L    R E+  P      E++  F +      
Sbjct: 177 GLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHR 236

Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
            P       P +   +   +    +GY QQDA EFL   ++ LH               N
Sbjct: 237 SPHI-----PYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDD--------N 283

Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYR 390
           G   + P     ++++                          +F G L+S + CQ C   
Sbjct: 284 GKKANNPNHCNCIIDQ--------------------------IFTGGLQSDVTCQVCHGV 317

Query: 391 STTFEVFCDLSLPIPK-------------------KGFAGGKVSLRDCFNLFTKEEELES 431
           STT + F D+SL +P                    +    G  +L DC   FT+ E L S
Sbjct: 318 STTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGS 377

Query: 432 ENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGD 491
                C  C     STK+LT+++ P +   HL RF  S    +K +  V FPL+ L +  
Sbjct: 378 SAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LDMTP 436

Query: 492 FASDKAGSPV----------------YQLYALCNHSGSVHYGHYTALCR-CQTGWHVYND 534
           F +    S +                Y L+A+ NH G++  GHYT+  R  +  W   +D
Sbjct: 437 FMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDD 496

Query: 535 SRVSPVSENQVASSEGYVLFY 555
           + ++  S   V  SEGY+LFY
Sbjct: 497 AIITKASIKDVLDSEGYLLFY 517


>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
          Length = 1123

 Score =  130 bits (326), Expect = 4e-30
 Identities = 102/355 (28%), Positives = 158/355 (44%), Gaps = 69/355 (19%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGG------RAQELTEAFADVI 266
           GL NLGNTCFLNA +QCL+ T PL ++ L ++  +    G           + +AFA+  
Sbjct: 123 GLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN-- 180

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
                  S  A+ P  F    +K    F   +Q+DA EFL+  ++ +             
Sbjct: 181 -------SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQ------------ 221

Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSK---IVDLFVGQLKSCLK 383
                                      +A L     L+R+      +  +F G L+S +K
Sbjct: 222 ---------------------------KACLNGCAKLDRQTQATTLVHQIFGGYLRSRVK 254

Query: 384 CQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQK 443
           C  C   S T++ + D++L I +        ++     LF K + L  ENA +C +C++K
Sbjct: 255 CSVCKSVSDTYDPYLDVALEIRQAA------NIVRALELFVKADVLSGENAYMCAKCKKK 308

Query: 444 TRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV-Y 502
             ++K+ T+ R   +L L L RF+   G   K +  V +P + L++  + S   G PV Y
Sbjct: 309 VPASKRFTIHRTSNVLTLSLKRFANFSGG--KITKDVGYP-EFLNIRPYMSQNNGDPVMY 365

Query: 503 QLYALCNHSG-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
            LYA+  HSG S H GHY    +   G W+  NDS V   +   V + + YVLFY
Sbjct: 366 GLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFY 420


>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
          Length = 952

 Score =  128 bits (321), Expect = 2e-29
 Identities = 77/202 (38%), Positives = 111/202 (54%), Gaps = 21/202 (10%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV----PGGGRAQELTEAFADV 265
           G  GL NLGNTCF+N+ +QCLS+T PL ++ L   +++E+    P G R  E+ +++A++
Sbjct: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRG-EIAKSYAEL 316

Query: 266 IGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325
           I  +W       V P  F+    ++ P FSGY QQD QE L  L++ LH ++NR  R+ P
Sbjct: 317 IKQMWS-GKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI-RKKP 374

Query: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385
            I        P +    + EE            W+ +L+R DS IVD+F G  KS L C 
Sbjct: 375 YIQLKDADGRPDK---VVAEEA-----------WENHLKRNDSIIVDIFHGLFKSTLVCP 420

Query: 386 ACGYRSTTFEVFCDLSLPIPKK 407
            C   S TF+ FC L+LP+P K
Sbjct: 421 ECAKISVTFDPFCYLTLPLPMK 442



 Score =  116 bits (290), Expect = 6e-26
 Identities = 65/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%)

Query: 405 PKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLN 464
           PKK F    V L+DC  LFT +E+L +E+   C  C++  ++TKKL +   P +LV+HL 
Sbjct: 752 PKKPF----VKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLK 807

Query: 465 RFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSPVYQLYALCNHSGSVHYGHYTALC 523
           RFS SR    K    VDFP+  L + +F  +  AG   Y L A+ NH G +  GHYTA  
Sbjct: 808 RFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFA 867

Query: 524 RCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
           + +    W+ ++DS VS  SE+Q+ S   YVLFYQ
Sbjct: 868 KNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 902


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score =  127 bits (320), Expect = 2e-29
 Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
           G  GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++  E+      G   E+ EA+A++I
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
             +W       V P  F+    ++ P FSGY QQD+QE L  L++ LH ++NR  ++  P
Sbjct: 360 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 416

Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
            L        P             D   A   W+ +  R DS IVD F G  KS L C  
Sbjct: 417 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 463

Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
           C   S TF+ FC L+LP+P K
Sbjct: 464 CAKVSVTFDPFCYLTLPLPLK 484



 Score =  111 bits (277), Expect = 2e-24
 Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)

Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
           V+LRDC  LFT  E L   +   C  C++  ++TKK  +   P+ILV+HL RFS +R   
Sbjct: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835

Query: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
            K    V+FP++ L++ +F  + +  P VY L A+ NH G++  GHYTA  + +    W+
Sbjct: 836 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 895

Query: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
            ++DS VS  SE+Q+ +   YVLFYQ
Sbjct: 896 YFDDSNVSLASEDQIVTKAAYVLFYQ 921


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score =  127 bits (320), Expect = 2e-29
 Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
           G  GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++  E+      G   E+ EA+A++I
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
             +W       V P  F+    ++ P FSGY QQD+QE L  L++ LH ++NR  ++  P
Sbjct: 313 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 369

Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
            L        P             D   A   W+ +  R DS IVD F G  KS L C  
Sbjct: 370 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 416

Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
           C   S TF+ FC L+LP+P K
Sbjct: 417 CAKVSVTFDPFCYLTLPLPLK 437



 Score =  111 bits (277), Expect = 2e-24
 Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)

Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
           V+LRDC  LFT  E L   +   C  C++  ++TKK  +   P+ILV+HL RFS +R   
Sbjct: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788

Query: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
            K    V+FP++ L++ +F  + +  P VY L A+ NH G++  GHYTA  + +    W+
Sbjct: 789 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 848

Query: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
            ++DS VS  SE+Q+ +   YVLFYQ
Sbjct: 849 YFDDSNVSLASEDQIVTKAAYVLFYQ 874


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score =  126 bits (317), Expect = 5e-29
 Identities = 104/380 (27%), Positives = 158/380 (41%), Gaps = 77/380 (20%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQ--ELTEAFADVIGALW 270
           GL NLGNTCF+N ++Q L+ T  LRDF L    R E+P        E++  F ++     
Sbjct: 79  GLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNP 138

Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
            P       P +   +   +    +GY QQDA EFL   ++ LH     R  +   +   
Sbjct: 139 SPHV-----PYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLH-----RHCKGDDV--- 185

Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYR 390
           G   + P     ++++                          +F G L+S + CQAC   
Sbjct: 186 GKAANNPNHCNCIIDQ--------------------------IFTGGLQSDVTCQACHGV 219

Query: 391 STTFEVFCDLSLPIPK------------------KGFAGGKVSLRDCFNLFTKEEELESE 432
           STT +   D+SL +P                   +    G  +L DC   FT+ E L S 
Sbjct: 220 STTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSS 279

Query: 433 NAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDF 492
               C  C+    STK+LT+ + P +   H  RF  S    +K +  + FPL+ L +  F
Sbjct: 280 AKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPF 338

Query: 493 ASDKAGSPV----------------YQLYALCNHSGSVHYGHYTALCR-CQTGWHVYNDS 535
            +    S +                Y L+A+ NH G++  GHYT+  R  +  W   +D+
Sbjct: 339 MASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDA 398

Query: 536 RVSPVSENQVASSEGYVLFY 555
            ++  S   V  SEGY+LFY
Sbjct: 399 VITKASIKDVLDSEGYLLFY 418


>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
          Length = 1318

 Score =  124 bits (312), Expect = 2e-28
 Identities = 78/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
           G  GL NLGNTCF+N+V+Q LS+TR LRDF   R F  E+      G    L   FA ++
Sbjct: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
            ALW   +  A  P++ +A+       F+GY+Q DAQEF+  L++ LH ++NR       
Sbjct: 555 RALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNR------- 606

Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
            + N P        G         D+  A   W+R+  R DS IVDLF GQ KS L C  
Sbjct: 607 -IQNKPYTETVDSDGR-------PDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 658

Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
           C   S TF+ F  L +P+P+K
Sbjct: 659 CAKVSITFDPFLYLPVPLPQK 679



 Score =  104 bits (259), Expect = 2e-22
 Identities = 62/169 (36%), Positives = 90/169 (53%), Gaps = 18/169 (10%)

Query: 412  GKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRG 471
            G  +L  C NLFT+ E L  E A  C +C+Q   ++K+L + R P +L++ L RFS  R 
Sbjct: 1056 GHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFS-FRS 1114

Query: 472  SIKKSSVG--VDFPLQRLSLGDF--ASDKAGSPVYQLYALCNHSGSVHYGHYTALC---- 523
             I +  +   V+FP++ L L  F     +   P Y LYA+ NH G +  GHYTA      
Sbjct: 1115 FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN 1174

Query: 524  -----RCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQL----MQEPPR 563
                 R   GW +++DS V+ V E+QV +   YVLFY+     ++ PPR
Sbjct: 1175 DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223


>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
          Length = 1316

 Score =  124 bits (310), Expect = 3e-28
 Identities = 100/349 (28%), Positives = 152/349 (43%), Gaps = 57/349 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+NLGNTCF NA LQCL+ T PL ++ L  +  +     G     T   A +  AL +P
Sbjct: 112 GLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQ-AHITQALSNP 170

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
              + + P       ++    F   +Q+DA EFL+  ++ +                   
Sbjct: 171 G--DVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQ------------------ 210

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSK---IVDLFVGQLKSCLKCQACGY 389
                                +A L     L+R       +  +F G L+S +KC  C  
Sbjct: 211 ---------------------KACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKG 249

Query: 390 RSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKK 449
            S TF+ + D++L I          S+      F K E+L+ EN+  C +C++   ++K+
Sbjct: 250 VSDTFDPYLDITLEIK------AAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKR 303

Query: 450 LTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALC 508
            T+ R   +L L L RF+   G   K +  V +P + L +  + S   G P VY LYA+ 
Sbjct: 304 FTIHRSSNVLTLSLKRFANFTGG--KIAKDVKYP-EYLDIRPYMSQPNGEPIVYVLYAVL 360

Query: 509 NHSG-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
            H+G + H GHY    +   G W+  NDS VS      V S + YVLFY
Sbjct: 361 VHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFY 409


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score =  120 bits (300), Expect = 4e-27
 Identities = 105/381 (27%), Positives = 156/381 (40%), Gaps = 79/381 (20%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR--QEVPGGGRAQELTEAFADVIGALW 270
           GL NLGNTCF+N ++Q L+    L+DF L    +     P      E++  F  +     
Sbjct: 364 GLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSR 423

Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
            P       P +   +   +    +GY QQDA EFL  +++ LH                
Sbjct: 424 TPHI-----PYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRH-------------- 464

Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVD-LFVGQLKSCLKCQACGY 389
               S    GG     P   +                  I+D +F G L+S + CQAC  
Sbjct: 465 ----SKDDSGGQEANNPNCCNC-----------------IIDQIFTGGLQSDVTCQACHS 503

Query: 390 RSTTFEVFCDLSLPIP-------------------KKGFAGGKVSLRDCFNLFTKEEELE 430
            STT +   D+SL +P                   +     G  SL DC   FT+ E L 
Sbjct: 504 VSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLG 563

Query: 431 SENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLG 490
           S     C+ C+    STK+LT+++ P +   HL RF       +K +  + FPL+ L + 
Sbjct: 564 SSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMT 622

Query: 491 DFASD------KAGSP---------VYQLYALCNHSGSVHYGHYTALCRCQTG-WHVYND 534
            F +       K G P          Y L+A+ NH G++  GHYT+  R Q   W   +D
Sbjct: 623 PFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDD 682

Query: 535 SRVSPVSENQVASSEGYVLFY 555
           + ++  +   +  SEGY+LFY
Sbjct: 683 AIITKATIEDLLYSEGYLLFY 703



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 1/67 (1%)

Query: 31  PRARSKERRNPASGPNPMLRPLPPRPGLPDERLK-KLELGRGRTSGPRPRGPLRADHGVP 89
           PRARS+ +   ++ P P  RP PP P  P    + +   G  R S P  R   R      
Sbjct: 110 PRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGD 169

Query: 90  LPGSPPP 96
           L GS  P
Sbjct: 170 LDGSGDP 176


>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
          Length = 828

 Score =  118 bits (295), Expect = 2e-26
 Identities = 96/341 (28%), Positives = 140/341 (41%), Gaps = 55/341 (16%)

Query: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
           C  +N       F K   S S     + QE +K+ +     E    ++      P IL +
Sbjct: 369 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 428

Query: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
               +P     P + G L     P       A+   K+  ++  S I D+F G + S ++
Sbjct: 429 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 488

Query: 384 CQACGYRSTTFEVFCDLSLPIP-------------------------------------- 405
           C  C   S T E F DLSLPIP                                      
Sbjct: 489 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 548

Query: 406 --KKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
             K  F G  V+L+DC   F   +EL+ +N   C++C++     K   VQ FP IL +HL
Sbjct: 549 YVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHL 608

Query: 464 NRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGSVHYGHYTA 521
            RF        K S  V FPL+ L L  F +  + + +  Y L ++  H G+   GHY A
Sbjct: 609 KRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIA 668

Query: 522 LCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
            CR      W+ ++D  V+ VSE+ V ++E YVLFY+   E
Sbjct: 669 YCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 709



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)

Query: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
           L   G  GL+N+GNTC++NA LQ LS+  PL  F L      +  G  R  +   + +++
Sbjct: 179 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 232

Query: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
             ++  LWH     +V PT      +   P+F GYSQQDAQEFL+ LM+ LH E+  +
Sbjct: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 290


>gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo
           sapiens]
          Length = 530

 Score =  118 bits (295), Expect = 2e-26
 Identities = 101/346 (29%), Positives = 156/346 (45%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMK---------------KAC 176

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
           +P     G   ++ P                 ++ + I  +F G  +S +KC  C   S 
Sbjct: 177 LP-----GHKQVDHPS----------------KDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S +   P VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFY 372


>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
          Length = 1604

 Score =  118 bits (295), Expect = 2e-26
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 35/225 (15%)

Query: 196 SDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG--- 252
           +  K+  H +    G  GL NLGNTCF+N+ +QC+S+T+PL  + +      E+      
Sbjct: 718 NSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPI 777

Query: 253 GRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMER 312
           G    + + + D++  LW     + V P + R    KY P F+G+ QQD+QE L  L++ 
Sbjct: 778 GMKGHMAKCYGDLVQELWSGTQ-KNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDG 836

Query: 313 LHLEINRRGRRAPPILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLE 364
           LH ++NR                       + E+P  EL D D       A   W  +L 
Sbjct: 837 LHEDLNR-----------------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLR 873

Query: 365 REDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409
           R  S +VDLF GQL+S +KC+ CG+ S  F+ F  LSLP+P   +
Sbjct: 874 RNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 918



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 34/97 (35%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 414  VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
            ++L  C   FT EEEL       C +C+    +TKKL + R P IL++HL RF    G  
Sbjct: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292

Query: 474  KKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNH 510
             KS   V FP +       + D +   V +  ALC H
Sbjct: 1293 IKSQKIVKFPRE-------SFDPSAFLVPRDPALCQH 1322



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 488  SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544
            S  D   D    P+Y LYA+  HSG +  GHY    +   C+  W+ YNDS    +  ++
Sbjct: 1496 STDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCK--WYCYNDSSCKELHPDE 1553

Query: 545  VASSEGYVLFYQ 556
            + +   Y+LFY+
Sbjct: 1554 IDTDSAYILFYE 1565


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score =  117 bits (294), Expect = 2e-26
 Identities = 73/211 (34%), Positives = 106/211 (50%), Gaps = 35/211 (16%)

Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
           G  GL NLGNTCF+N+ +QC+S+T+PL  + +      E+      G    + + + D++
Sbjct: 530 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 589

Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
             LW     ++V P + R    KY P F G+ QQD+QE L  L++ LH ++NR       
Sbjct: 590 QELWSGTQ-KSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNR------- 641

Query: 327 ILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLEREDSKIVDLFVGQL 378
                           + E+P  EL D D       A   W  +L R  S IVDLF GQL
Sbjct: 642 ----------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQL 685

Query: 379 KSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409
           +S +KC+ CG+ S  F+ F  LSLP+P   +
Sbjct: 686 RSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 716



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 488  SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544
            S  D   D    P+Y LYA+  HSG +  GHY    +   C+  W+ YNDS    +  ++
Sbjct: 1298 STDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCK--WYCYNDSSCEELHPDE 1355

Query: 545  VASSEGYVLFYQ 556
            + +   Y+LFY+
Sbjct: 1356 IDTDSAYILFYE 1367



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 21/53 (39%), Positives = 29/53 (54%)

Query: 414  VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF 466
            ++L  C   FT EEEL       C +C+    +TKKL + R P  L++HL RF
Sbjct: 1031 INLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRF 1083


>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1
           [Homo sapiens]
          Length = 530

 Score =  117 bits (293), Expect = 3e-26
 Identities = 101/346 (29%), Positives = 156/346 (45%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   + +D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQAD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S +   P VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372


>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
           sapiens]
          Length = 359

 Score =  117 bits (292), Expect = 4e-26
 Identities = 100/365 (27%), Positives = 158/365 (43%), Gaps = 54/365 (14%)

Query: 211 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL- 269
           + GL N GNTC+ N+VLQ L   RP R+  L    +Q+     + + L    AD+  ++ 
Sbjct: 27  YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQK-----KKENLLTCLADLFHSIA 81

Query: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRRAPPI 327
                   + P +F +  +K    F  Y QQDA EFL  L+  +   L+  ++  +    
Sbjct: 82  TQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGK 141

Query: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
           L NG +  P             +++++  L W          + ++F G L +  +C  C
Sbjct: 142 LKNGNMNEP-------------AENNKPELTW----------VHEIFQGTLTNETRCLNC 178

Query: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
              S+  E F DLS+ + +        S+  C   F+  E L SE    C+ C  K  + 
Sbjct: 179 ETVSSKDEDFLDLSVDVEQN------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ 232

Query: 448 KKLTVQRFPRILVLHLNRFS--ASRGSIKKSSVGVDFPLQRLSLGDFASDKAG-SPVYQL 504
           K++ V++ P IL LHL RF          K S  V FPL+ L L + +SD      +Y L
Sbjct: 233 KRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDL 291

Query: 505 YALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------SSEGY 551
            A+  H GS  + GHY  + +    W +++D  V  +    +             S  GY
Sbjct: 292 VAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGY 351

Query: 552 VLFYQ 556
           +LFYQ
Sbjct: 352 ILFYQ 356


>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
           sapiens]
          Length = 366

 Score =  117 bits (292), Expect = 4e-26
 Identities = 100/365 (27%), Positives = 158/365 (43%), Gaps = 54/365 (14%)

Query: 211 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL- 269
           + GL N GNTC+ N+VLQ L   RP R+  L    +Q+     + + L    AD+  ++ 
Sbjct: 34  YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQK-----KKENLLTCLADLFHSIA 88

Query: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRRAPPI 327
                   + P +F +  +K    F  Y QQDA EFL  L+  +   L+  ++  +    
Sbjct: 89  TQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGK 148

Query: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
           L NG +  P             +++++  L W          + ++F G L +  +C  C
Sbjct: 149 LKNGNMNEP-------------AENNKPELTW----------VHEIFQGTLTNETRCLNC 185

Query: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
              S+  E F DLS+ + +        S+  C   F+  E L SE    C+ C  K  + 
Sbjct: 186 ETVSSKDEDFLDLSVDVEQN------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ 239

Query: 448 KKLTVQRFPRILVLHLNRFS--ASRGSIKKSSVGVDFPLQRLSLGDFASDKAG-SPVYQL 504
           K++ V++ P IL LHL RF          K S  V FPL+ L L + +SD      +Y L
Sbjct: 240 KRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDL 298

Query: 505 YALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------SSEGY 551
            A+  H GS  + GHY  + +    W +++D  V  +    +             S  GY
Sbjct: 299 VAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGY 358

Query: 552 VLFYQ 556
           +LFYQ
Sbjct: 359 ILFYQ 363


>gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo
           sapiens]
          Length = 530

 Score =  117 bits (292), Expect = 4e-26
 Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   +  D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S +   P VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFY 372


>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1
           [Homo sapiens]
          Length = 530

 Score =  116 bits (290), Expect = 6e-26
 Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   +  D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S +   P VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372


>gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo
           sapiens]
          Length = 530

 Score =  116 bits (290), Expect = 6e-26
 Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   +  D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S +   P VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372


>gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
           sapiens]
          Length = 530

 Score =  115 bits (288), Expect = 1e-25
 Identities = 101/346 (29%), Positives = 154/346 (44%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   +  D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASD-KAGSPVYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S    G  VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQPNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372


>gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
           sapiens]
          Length = 530

 Score =  115 bits (288), Expect = 1e-25
 Identities = 101/346 (29%), Positives = 154/346 (44%), Gaps = 57/346 (16%)

Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
           GL+N+GNTC++NA LQCL+ T PL ++ L R+  Q      +   L    A +  AL +P
Sbjct: 81  GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139

Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
                + P+      Q     F    Q+DA EFL   ++ +                   
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174

Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
                    A L   +  D          +  ++ + I  +F G  +S +KC  C   S 
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215

Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
           TF+ + D++L I          S++       K EEL  ENA  C  C Q+  ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASD-KAGSPVYQLYALCNHS 511
               ++L+L L RFS   G+  K +  V +P + L +  + S    G  VY LYA+  H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQPNTGPLVYVLYAVLVHA 326

Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
           G S H GHY +  + Q G W+  +D+ V+  S   V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,866,048
Number of Sequences: 37866
Number of extensions: 1555195
Number of successful extensions: 8527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 7144
Number of HSP's gapped (non-prelim): 1471
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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