Search of human proteins with 61743914

Search of human proteins with 61743914

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
precursor [Homo sapiens]
         (517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...  1048   0.0  
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   479   e-135
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   450   e-126
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   374   e-103
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   327   1e-89
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     318   6e-87
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   284   2e-76
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   283   3e-76
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    281   8e-76
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   278   1e-74
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   261   8e-70
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   250   2e-66
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   248   1e-65
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   246   5e-65
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   234   1e-61
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   222   7e-58
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   217   2e-56
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              152   9e-37
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   146   5e-35
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   144   3e-34
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   140   3e-33
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   124   2e-28
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   124   2e-28
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   122   1e-27
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              103   5e-22
gi|4504023 glycine receptor, beta [Homo sapiens]                       73   7e-13
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...    70   4e-12
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...    69   1e-11
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...    68   2e-11
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...    68   2e-11

>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 517/517 (100%), Positives = 517/517 (100%)

Query: 1   MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLT 60
           MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLT
Sbjct: 1   MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLT 60

Query: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120
           NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG
Sbjct: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120

Query: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180
           VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL
Sbjct: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180

Query: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240
           QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK
Sbjct: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240

Query: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300
           PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ
Sbjct: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300

Query: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR 360
           AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR
Sbjct: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR 360

Query: 361 PLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGP 420
           PLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGP
Sbjct: 361 PLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGP 420

Query: 421 ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAM 480
           ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAM
Sbjct: 421 ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAM 480

Query: 481 LSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD 517
           LSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD
Sbjct: 481 LSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD 517


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  479 bits (1234), Expect = e-135
 Identities = 258/503 (51%), Positives = 329/503 (65%), Gaps = 20/503 (3%)

Query: 5   QGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLIS 64
           + PL +LLLL +     G+N+E RL   L  NYDP  RP     D V +SLK+TLTNLIS
Sbjct: 3   RAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62

Query: 65  LNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEV 124
           LNE+EE LTT+VWI + W DYRL +   D+ G+  LRVPS +VW P+IVLENN+DG F V
Sbjct: 63  LNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGV 122

Query: 125 ALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS- 183
           A   NVLV   G + WLPPAI+RS C++ VTYFPFDWQNCSLIF+SQTY+  E++   + 
Sbjct: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182

Query: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243
             DG+TI  I ID EA+TENGEWAI   P  +           G   V++ L+I+RKPLF
Sbjct: 183 DNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLF 242

Query: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303
           YVINII PCVLIS + +L +FLPA+AGGQKCTV+INVLLAQTVFLFL+A+K+PETS +VP
Sbjct: 243 YVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 302

Query: 304 LISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA 363
           L+ ++L F++VV  LIV+N V+VLNVS R+P TH+M+  +R V L LLP+LL     P A
Sbjct: 303 LLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEA 362

Query: 364 PAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQ-QWQRQGLVAAALEKLEKGPEL 422
           P A     S  +  SS   +   EE+ L  PRSEL+F+ Q  RQG   AA          
Sbjct: 363 PRAA----SPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAA---------- 408

Query: 423 GLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLS 482
               FC SL  AAP ++ CV+A N +A +   Q        +W  +G  LD +CF A L 
Sbjct: 409 ----FCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALV 464

Query: 483 LFICGTAGIFLMAHYNRVPALPF 505
           LF  G++ IFL A++NRVP LP+
Sbjct: 465 LFSVGSSLIFLGAYFNRVPDLPY 487


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  450 bits (1157), Expect = e-126
 Identities = 246/524 (46%), Positives = 331/524 (63%), Gaps = 32/524 (6%)

Query: 5   QGPLL---LLLLLAVCLGAQGRNQEERLLADLMQN--YDPNLRPAERDSDVVNVSLKLTL 59
           +GP+L   LL  LAVC G+ G N+EERL+  L Q   Y+  LRP     + V+V+L LTL
Sbjct: 2   EGPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL 60

Query: 60  TNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVD 119
           +NLISL E EE LTTNVWIE  W D RL+W+  ++  + VLR+P  MVW P+IVLENN D
Sbjct: 61  SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND 120

Query: 120 GVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEID 179
           G F+++  CNVLV   G +YWLPPAIFRS+C ISVTYFPFDWQNCSL F S  Y+  EI 
Sbjct: 121 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT 180

Query: 180 LQLSQEDGQT----IEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYL 235
           L L Q+  +     +EWI IDPE FTENGEW I HRPA++ +DP AP      Q + FYL
Sbjct: 181 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL 240

Query: 236 LIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKV 295
           +I+RKPLFY+INI+ PCVLIS +  L+ +LPA + G+K +VAI+VLLAQ+VFL L++K++
Sbjct: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLLLISKRL 299

Query: 296 PETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLL 355
           P TS A+PLI K+L F +V+  ++VV  V+VLN+  R+P TH ++ GV+K+FL  LP+LL
Sbjct: 300 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL 359

Query: 356 RMHVRPL----APAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAA 411
            M  RP     +P A+      ++  SS   I+  EE  L   RS+L+F++   +  +A 
Sbjct: 360 HMS-RPAEDGPSPGAL------VRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLAR 412

Query: 412 ALEKLEKGP---ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLV 468
            L    + P   E    +    LK A       V+  N I      Q++++   + W  V
Sbjct: 413 RLTTARRPPASSEQAQQELFNELKPA-------VDGANFIVNHMRDQNNYNEEKDSWNRV 465

Query: 469 GRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPY 512
            R +DR+C   +  + + GTA IFL   YN+ P  PFPGDP  Y
Sbjct: 466 ARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSY 509


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  374 bits (959), Expect = e-103
 Identities = 212/510 (41%), Positives = 301/510 (59%), Gaps = 21/510 (4%)

Query: 7   PLLLLLLLA-----VCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTN 61
           P  LL+LL      +  G +G   E RL   L   YD ++RPA    D V VS+ L L  
Sbjct: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQ 62

Query: 62  LISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGV 121
           LISLNE++E ++T V+++++W DYRL WDP +++G+  LR+ +  VW PD+VL NN DG 
Sbjct: 63  LISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122

Query: 122 FEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ 181
           F+VAL  +V+VS DG + W PP I+RS+CSI VTYFPFDWQNC+++F S +Y ++E+ LQ
Sbjct: 123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQ 182

Query: 182 LS-QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAP--AQEAGHQKVVFYLLIQ 238
                DGQ  + I I    F ENG+W I H+P++++  P  P   +E   Q+V+FYL+I+
Sbjct: 183 TGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIR 242

Query: 239 RKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPET 298
           RKPLFY++N+IAPC+LI+ +AI + +LP  A G+K  ++I  LL  TVFL L+A KVPET
Sbjct: 243 RKPLFYLVNVIAPCILITLLAIFVFYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPET 301

Query: 299 SQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMH 358
           S +VP+I KYL F +V+    V+ +VVVLN+  RSPHTH M   VR++F+  LP  LR+ 
Sbjct: 302 SLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLK 361

Query: 359 VRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQR--QGLVAAALEKL 416
            RP     +        +  SGW   T +E  +  P S+ LF +  R    L A  L + 
Sbjct: 362 -RPKPERDLMPEPPHCSSPGSGWGRGT-DEYFIRKPPSDFLFPKPNRFQPELSAPDLRRF 419

Query: 417 EKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVC 476
             GP   ++          P ++  V + + IA    +Q   D   E+W  V  V+DR+ 
Sbjct: 420 IDGPNRAVA--------LLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLF 471

Query: 477 FLAMLSLFICGTAGIFLMAHYNRVPALPFP 506
               +     GT  IFL A Y+  P  PFP
Sbjct: 472 LWTFIIFTSVGTLVIFLDATYHLPPPDPFP 501


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  327 bits (839), Expect = 1e-89
 Identities = 198/511 (38%), Positives = 286/511 (55%), Gaps = 36/511 (7%)

Query: 6   GPLLLLL---LLAVCLGAQGRNQEERLLADLMQ--NYDPNLRPAERDSDVVNVSLKLTLT 60
           GP+ LLL   LL +C G  G + EERL+  L+    Y+  +RPA   S++V V L ++L 
Sbjct: 6   GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65

Query: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120
            LIS++ERE+ +TTNVW+  +W DYRL W P +++ +  +R+PS  +W PD+VL NN DG
Sbjct: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125

Query: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180
           ++EV+ Y N +VS DG I+WLPPAI++SAC I V +FPFD QNC++ F+S TY   EIDL
Sbjct: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185

Query: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240
            L  E            + FT +GEW I   P +   +P     ++ +  + +  +I+RK
Sbjct: 186 VLKSEVASL--------DDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRK 233

Query: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300
           PLFY IN+I PCVLI+S+AIL+ +LP+   G+K T+ I+VLLA TVFL L++K VP TS 
Sbjct: 234 PLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKIVPPTSL 292

Query: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR 360
            VPL+ KYL F +V+    +V +V VLNV  RSP TH+MA  V+ VFL  LP LL M  +
Sbjct: 293 DVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQ-Q 351

Query: 361 PLAPAAVQDTQSRLQN------GSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALE 414
           P    A Q  + R +       G+  +    G +   C      +      QGL  A   
Sbjct: 352 PRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASV------QGLAGAF-- 403

Query: 415 KLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDR 474
             E  P  G  +   S +     ++  V+    IA     +    + +E+W  V  V+DR
Sbjct: 404 GAEPAPVAGPGR---SGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDR 460

Query: 475 VCFLAMLSLFICGTAGIFLMAHYNRVPALPF 505
           +     + + + GT G+FL   +       F
Sbjct: 461 LFLWIFVFVCVFGTIGMFLQPLFQNYTTTTF 491


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  318 bits (816), Expect = 6e-87
 Identities = 189/492 (38%), Positives = 275/492 (55%), Gaps = 25/492 (5%)

Query: 8   LLLLLLLAVCLGAQGR--NQEERLLADLMQN--YDPNLRPAERDSDVVNVSLKLTLTNLI 63
           L+L  L+A+C     R  N EE+L+ DL+    Y+  +RPA   S ++++ L+L+L  LI
Sbjct: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66

Query: 64  SLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFE 123
           S+NERE+ +TTNVW++ +W DYRL W+   YEG+ +LR+P+  +W PDIVL NN DG +E
Sbjct: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126

Query: 124 VALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLS 183
           V++Y N++V  +G + WLPPAI++SAC I V YFPFD QNC+L F+S TY   EID+ L 
Sbjct: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186

Query: 184 QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLF 243
                         + FT +GEW I   P +  ++P    Q+  +  V +  +I+RKPLF
Sbjct: 187 TPTASM--------DDFTPSGEWDIVALPGRRTVNP----QDPSYVDVTYDFIIKRKPLF 234

Query: 244 YVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVP 303
           Y IN+I PCVL + +AIL+ +LP+   G+K T+ I+VLLA T FL L++K VP TS  VP
Sbjct: 235 YTINLIIPCVLTTLLAILVFYLPSDC-GEKMTLCISVLLALTFFLLLISKIVPPTSLDVP 293

Query: 304 LISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA 363
           LI KYL F +V+    +V +V VLNV  RSP TH+MA  V++ FL  LP  L M  RP  
Sbjct: 294 LIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMK-RP-- 350

Query: 364 PAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELG 423
                D+        S   +T  E  A     S             +AA +       + 
Sbjct: 351 ---GPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVA 407

Query: 424 LSQ--FCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAML 481
           + +  +  S  +    +Q  +E  + IA          +  E+W  V  V+DR+     +
Sbjct: 408 IPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFM 467

Query: 482 SLFICGTAGIFL 493
            + + GT G+FL
Sbjct: 468 FVCVLGTVGLFL 479


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  284 bits (726), Expect = 2e-76
 Identities = 173/486 (35%), Positives = 257/486 (52%), Gaps = 27/486 (5%)

Query: 19  GAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWI 78
           G      E+RL   L + Y+   RP    SDVV V   L++  LI ++E+ + +TTNVW+
Sbjct: 52  GGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWL 111

Query: 79  EMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCI 138
           + +W DY+LRW+P D+  +  LRVPS M+W PDIVL NN DG F V       +   G +
Sbjct: 112 KQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTV 171

Query: 139 YWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPE 198
           +W+PPAI++S+CSI VT+FPFD QNC + F S TY   +IDL+  ++         +D +
Sbjct: 172 HWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT--------VDLK 223

Query: 199 AFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSV 258
            + E+GEWAI +              E  +  V +  +I+R PLFY IN+I PC+LIS +
Sbjct: 224 DYWESGEWAIVNATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYTINLIIPCLLISCL 282

Query: 259 AILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTIL 318
            +L+ +LP+   G+K T+ I+VLL+ TVFL L+ + +P TS  +PLI +YL F ++   L
Sbjct: 283 TVLVFYLPSDC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTL 341

Query: 319 IVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGS 378
            +V  V VLNV  RSP TH+M   VR   L  +P+ L M+ RP  P  +        + S
Sbjct: 342 SIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMN-RPPPPVELCHPLRLKLSPS 400

Query: 379 SGW--SITTGEEVALCLPRSELLFQQWQRQGLVAAALEKL---------EKGPELGLSQF 427
             W  S    EE  + +   +    +W   G VA ++  L           GP+      
Sbjct: 401 YHWLESNVDAEEREVVVEEED----RWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQ 456

Query: 428 CGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICG 487
            G L   +P +Q  +E  + IA     +    +  E+W  V  V+DR+     + +   G
Sbjct: 457 EGEL-LLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLG 515

Query: 488 TAGIFL 493
           T G+FL
Sbjct: 516 TIGLFL 521


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  283 bits (724), Expect = 3e-76
 Identities = 159/372 (42%), Positives = 221/372 (59%), Gaps = 18/372 (4%)

Query: 7   PLLLLL---LLAVCLGAQGR-NQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62
           PLLLLL   LL      + R + EERLL  L   Y+   RP    SDVV V   L++  L
Sbjct: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73

Query: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122
           I ++E+ + +TTNVW++ +W DY+LRWDP DYE +  +R+PS ++WRPDIVL NN DG F
Sbjct: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133

Query: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182
            V       +  DG + W PPAI++S+CSI VT+FPFD QNC++ F S TY   +IDL  
Sbjct: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVN 193

Query: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242
                       +D   F E+GEW I                E  +  + +  +I+R PL
Sbjct: 194 MHSR--------VDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVIRRLPL 244

Query: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302
           FY IN+I PC+LIS + +L+ +LP++  G+K T+ I+VLL+ TVFL L+ + +P TS  +
Sbjct: 245 FYTINLIIPCLLISCLTVLVFYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVI 303

Query: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPL 362
           PLI +YL F ++   L +V  V VLNV  RSP TH+M   VR+VFL ++P+LL M     
Sbjct: 304 PLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMK---- 359

Query: 363 APAAVQDTQSRL 374
            P+ V+D   RL
Sbjct: 360 RPSVVKDNCRRL 371



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 17/59 (28%), Positives = 28/59 (47%)

Query: 435 APAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFL 493
           +PA+   VE    IA     +    +  E+W  V  V+DR+     + + + GT G+FL
Sbjct: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  281 bits (720), Expect = 8e-76
 Identities = 176/501 (35%), Positives = 262/501 (52%), Gaps = 33/501 (6%)

Query: 4   GQGPLLLLLLLAVCL------GAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKL 57
           GQG L   L L +C+      G  G   EERL   L  +Y+  +RP E  SD V V  ++
Sbjct: 6   GQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEV 65

Query: 58  TLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENN 117
            +T L +++E  + + TN+W+   W DY+LRWDP +Y+G+  LRVP+  +W+PDIVL NN
Sbjct: 66  AITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNN 125

Query: 118 VDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNE 177
             G F+V      L+  +G I W PPAIF+S+C + +T+FPFD QNCSL F S TY   E
Sbjct: 126 AVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAE 185

Query: 178 IDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLI 237
           IDL +            +D   F EN EW I    +    D      E  +  + +   I
Sbjct: 186 IDLLIIGSK--------VDMNDFWENSEWEIID-ASGYKHDIKYNCCEEIYTDITYSFYI 236

Query: 238 QRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPE 297
           +R P+FY IN+I PC+ IS + +L+ +LP+   G+K T+ I+VLL+ TVFL ++ + +P 
Sbjct: 237 RRLPMFYTINLIIPCLFISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPS 295

Query: 298 TSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM 357
           TS  VPL+ +YL F ++   L +V  V VLN+  R+P TH+M R V+ VFL+LLPQ+L M
Sbjct: 296 TSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLM 355

Query: 358 H-----VRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAA 412
                  R     AV    +R    + G   + GE      PR         +   +A +
Sbjct: 356 RWPLDKTRGTGSDAVPRGLAR--RPAKGKLASHGE------PRHLKECFHCHKSNELATS 407

Query: 413 LEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVL 472
             +L   P     Q+     + +P ++  + +   IA      +      ++W  V  V+
Sbjct: 408 KRRLSHQP----LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVV 463

Query: 473 DRVCFLAMLSLFICGTAGIFL 493
           DRV     + + + GTAG+FL
Sbjct: 464 DRVFLWVFIIVCVFGTAGLFL 484


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  278 bits (710), Expect = 1e-74
 Identities = 169/497 (34%), Positives = 264/497 (53%), Gaps = 28/497 (5%)

Query: 8   LLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNE 67
           LLLLLLL++   A+    E RL   L ++Y+  +RP    SD V +  +++++ L+ ++E
Sbjct: 17  LLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDE 76

Query: 68  REEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALY 127
             + + TN+W++  W DY+L+W+P DY G   +RVP+  +W+PDIVL NN  G F+V   
Sbjct: 77  VNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDK 136

Query: 128 CNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDG 187
              L+   G + W+PPAIF+S+C I VTYFPFD+QNC++ F S +Y   +IDL L     
Sbjct: 137 TKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS- 195

Query: 188 QTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVIN 247
                  ++ + + E+GEWAI   P     D      E  +  + + L I+R PLFY IN
Sbjct: 196 -------MNLKDYWESGEWAIIKAPG-YKHDIKYNCCEEIYPDITYSLYIRRLPLFYTIN 247

Query: 248 IIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISK 307
           +I PC+LIS + +L+ +LP+   G+K T+ I+VLL+ TVFL ++ + +P TS  +PLI +
Sbjct: 248 LIIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE 306

Query: 308 YLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM---------- 357
           YL F ++   L +V  V VLNV  R+P TH+M   V+ VFL LLP+++ M          
Sbjct: 307 YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNA 366

Query: 358 -HVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKL 416
              RPL  A + +     +  S G       +  +C            R+  ++     L
Sbjct: 367 QKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMC-------GYCHHRRIKISNFSANL 419

Query: 417 EKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVC 476
            +           SL   +P I+  +++   IA     Q+      ++W  V  V+DR+ 
Sbjct: 420 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF 479

Query: 477 FLAMLSLFICGTAGIFL 493
                 + I GTAG+FL
Sbjct: 480 LWVFTLVCILGTAGLFL 496


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  261 bits (668), Expect = 8e-70
 Identities = 137/349 (39%), Positives = 207/349 (59%), Gaps = 9/349 (2%)

Query: 7   PLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLN 66
           PLLLL  L       G   E RL+A L ++Y   +RP E    VV V++ L L  LI+++
Sbjct: 5   PLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVD 64

Query: 67  EREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVAL 126
           E  + +TTNV ++ QW DY L+W+P DY G+  + +PS  +WRPD+VL NN DG F +  
Sbjct: 65  EVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVK 124

Query: 127 YCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQED 186
           +  VL+   G I W PPAIF+S C I VT+FPFD QNCS+   + TY  + +   ++ E 
Sbjct: 125 FTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV--AINPES 182

Query: 187 GQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVI 246
            Q       D   F E+GEW I+           +   +  +  + ++ ++QR PL++++
Sbjct: 183 DQP------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236

Query: 247 NIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLIS 306
           N+I PC+L S +  L+ +LP  + G+K T++I+VLL+ TVFL ++ + +P TS AVPLI 
Sbjct: 237 NVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 295

Query: 307 KYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLL 355
           KY+ F +V  I  ++  V+V+N   RSP TH M   VRKVF+  +P ++
Sbjct: 296 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIM 344


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  250 bits (638), Expect = 2e-66
 Identities = 141/379 (37%), Positives = 216/379 (56%), Gaps = 36/379 (9%)

Query: 4   GQGPLLLLLLLAVCL--------GAQGRNQ------------EERLLADLMQNYDPNLRP 43
           G GP  L LLL V L        GA G  Q            E+ LL DL Q+Y+  +RP
Sbjct: 5   GSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRP 64

Query: 44  AERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVP 103
            E  +D + +   L ++ L+ ++E+ + +TTNVW++ +W D +LRW+P DY G+ V+RVP
Sbjct: 65  VEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVP 124

Query: 104 STMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQN 163
           S  VW PDIVL +N DG FE       ++  +G + W PPA ++S+C+I VT+FPFD QN
Sbjct: 125 SDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQN 183

Query: 164 CSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPA 223
           CS+ F S TY  +++D+ L  +D        +D   F +NGEW I               
Sbjct: 184 CSMKFGSWTYDGSQVDIILEDQD--------VDKRDFFDNGEWEIVSATGS---KGNRTD 232

Query: 224 QEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLA 283
               +  V +  +I+R PLFY + +I PC+ +S + +L+ +LP+   G+K  +  +VL++
Sbjct: 233 SCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNE-GEKICLCTSVLVS 291

Query: 284 QTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTH-SMARG 342
            TVFL ++ + +P +S+ +PLI +YL F ++   L ++  V  +N+  RS  TH +MA  
Sbjct: 292 LTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPL 351

Query: 343 VRKVFLRLLPQLL--RMHV 359
           VRK+FL  LP+LL  R HV
Sbjct: 352 VRKIFLHTLPKLLCMRSHV 370


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  248 bits (632), Expect = 1e-65
 Identities = 137/374 (36%), Positives = 207/374 (55%), Gaps = 34/374 (9%)

Query: 7   PLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLN 66
           PLLLL  L       G   E RL+A L ++Y   +RP E    VV V++ L L  LI+++
Sbjct: 5   PLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVD 64

Query: 67  EREEALTTNVWIEM-------------------------QWCDYRLRWDPRDYEGLWVLR 101
           E  + +TTNV ++                          QW DY L+W+P DY G+  + 
Sbjct: 65  EVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIH 124

Query: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161
           +PS  +WRPD+VL NN DG F +  +  VL+   G I W PPAIF+S C I VT+FPFD 
Sbjct: 125 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDE 184

Query: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAA 221
           QNCS+   + TY  + +   ++ E  Q       D   F E+GEW I+           +
Sbjct: 185 QNCSMKLGTWTYDGSVV--AINPESDQP------DLSNFMESGEWVIKESRGWKHSVTYS 236

Query: 222 PAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVL 281
              +  +  + ++ ++QR PL++++N+I PC+L S +  L+ +LP  + G+K T++I+VL
Sbjct: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVL 295

Query: 282 LAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMAR 341
           L+ TVFL ++ + +P TS AVPLI KY+ F +V  I  ++  V+V+N   RSP TH M  
Sbjct: 296 LSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPN 355

Query: 342 GVRKVFLRLLPQLL 355
            VRKVF+  +P ++
Sbjct: 356 WVRKVFIDTIPNIM 369


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  246 bits (627), Expect = 5e-65
 Identities = 158/498 (31%), Positives = 272/498 (54%), Gaps = 64/498 (12%)

Query: 8   LLLLLLLAVCLGAQ-GRNQ----EERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62
           +L+L++L +   A  G N     E+ LL  L Q Y   +RP    +D + V   L ++ L
Sbjct: 6   MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQL 65

Query: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122
           + ++E+ + +TTNVW++ +W D++LRW+P DY G+  ++VPS  +W PDIVL  N DG F
Sbjct: 66  VDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRF 125

Query: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182
           E +L   V+V  +G + W PPA ++S+C++ VT+FPFD QNCS+ F S TY    +DL L
Sbjct: 126 EGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL 185

Query: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242
             E+        +D + F +NGEW I +  AK +         + +  + +  +++R PL
Sbjct: 186 INEN--------VDRKDFFDNGEWEILN--AKGMKGNRRDGVYS-YPFITYSFVLRRLPL 234

Query: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302
           FY + +I PC+ +S + +L+ +LP+   G+K +++ +VL++ TVFL ++ + +P +S+ +
Sbjct: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVI 293

Query: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHT-HSMARGVRKVFLRLLPQLLRM--HV 359
           PLI +YL F+++   L ++  V V+NV  RS  T H MA  V+++FL+ LP+LL M  HV
Sbjct: 294 PLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHV 353

Query: 360 RPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKG 419
              +    +++Q                     + + ++L ++ Q+Q         L  G
Sbjct: 354 DRYSSPEKEESQP--------------------VVKGKVLEKKKQKQ---------LSDG 384

Query: 420 PELGLSQFCGSLKQAAPAIQACVEACNLIACARH-QQSHF-DNGNEEWFLVGRVLDRVCF 477
            ++        L++AA +I+           +RH ++ HF     ++W  V +VLDR+  
Sbjct: 385 EKV----LVAFLEKAADSIR---------YISRHVKKEHFISQVVQDWKFVAQVLDRIFL 431

Query: 478 LAMLSLFICGTAGIFLMA 495
              L + + G+  IF  A
Sbjct: 432 WLFLIVSVTGSVLIFTPA 449


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  234 bits (597), Expect = 1e-61
 Identities = 163/514 (31%), Positives = 250/514 (48%), Gaps = 50/514 (9%)

Query: 3   GGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62
           GG    L   LL V L  QG  Q  +L  +L++NY+P  RP   DS  + V   L+L  +
Sbjct: 6   GGVWLALAASLLHVSL--QGEFQR-KLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQI 62

Query: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122
           + ++E+ + LTTN+W++M W D+ L+W+  +Y G+  +R P   +W+PDI+L N+ D  F
Sbjct: 63  MDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERF 122

Query: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182
           +   + NVLV+  G   +LPP IF+S+C I V +FPFD Q+C L F S +Y    +DLQ+
Sbjct: 123 DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM 182

Query: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242
            +           D   +  NGEW +   P K   +      +  +  V F + ++R+ L
Sbjct: 183 QE----------ADISGYIPNGEWDLVGIPGKR-SERFYECCKEPYPDVTFTVTMRRRTL 231

Query: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302
           +Y +N++ PCVLIS++A+L+  LPA + G+K ++ I VLL+ TVF+ LVA+ +P TS +V
Sbjct: 232 YYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPATSDSV 290

Query: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM----- 357
           PLI++Y    +++  L VV  V+VL      P    M +  R + L      LRM     
Sbjct: 291 PLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE 350

Query: 358 -HVRPLAPAAVQDTQSR---------------LQNGSSGWSITTGEEVALCLPRSELLFQ 401
             VRP    A Q  Q R                 NG+  +    G +   C+P  +    
Sbjct: 351 DKVRP----ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD---- 402

Query: 402 QWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNG 461
                G+V   +       E  L    G   +  P +   +E    IA     Q   +  
Sbjct: 403 ----SGVVCGRMACSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDESEAV 456

Query: 462 NEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495
             EW     V+DR+C +A     I  T GI + A
Sbjct: 457 CSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  222 bits (565), Expect = 7e-58
 Identities = 129/347 (37%), Positives = 190/347 (54%), Gaps = 12/347 (3%)

Query: 2   HGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTN 61
           H   G LLL LL A CLGA+GR    +L  DL  NY   LRP       +NV+L++TL+ 
Sbjct: 7   HLSLGLLLLFLLPAECLGAEGR-LALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQ 65

Query: 62  LISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGV 121
           +I ++ER + LT  +WI  +W D  LRWDP  Y GL  +R+PS++VWRPDIVL N  D  
Sbjct: 66  IIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQ 125

Query: 122 FEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ 181
              +   NV++  DG + W  PAI RS+C + V  FPFD Q+C L F S T+  +++D++
Sbjct: 126 PPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVR 185

Query: 182 LSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKP 241
                    +        F EN EW +   PA+  +       E  +  V F LL++R+ 
Sbjct: 186 PRGAAASLAD--------FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLRRRA 236

Query: 242 LFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQA 301
             YV N++ PCVLIS +A L   LPA + G+K ++ + VLLA TVF  L+A+ +P  +++
Sbjct: 237 AAYVCNLLLPCVLISLLAPLAFHLPADS-GEKVSLGVTVLLALTVFQLLLAESMP-PAES 294

Query: 302 VPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFL 348
           VPLI KY    + +        ++++N+    P    +    R + L
Sbjct: 295 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLL 341


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  217 bits (552), Expect = 2e-56
 Identities = 121/329 (36%), Positives = 185/329 (56%), Gaps = 11/329 (3%)

Query: 27  ERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYR 86
           ++L  DL ++Y   LRP E    V+NV+L++TL+ +  ++ER + LT  +WI   W D  
Sbjct: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91

Query: 87  LRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIF 146
           L WD   Y+GL  +R+PS +VWRPDIVL N  D      +  NV++  DG I W  PAI 
Sbjct: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151

Query: 147 RSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEW 206
           +S+C + VTYFPFD Q C+L F S TY+ N++D+  + + G        D   F E+ EW
Sbjct: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG--------DLSDFIEDVEW 203

Query: 207 AIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLP 266
            +   PA   +       E  +  V F LL++R+  FY++N++ PCVLIS +A L  +LP
Sbjct: 204 EVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLP 262

Query: 267 AKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVV 326
           A A G+K ++ + +LLA TVF  +VA+ +P  S+ VPLI KY    + +        ++V
Sbjct: 263 A-ASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGKYYIATMALITASTALTIMV 320

Query: 327 LNVSLRSPHTHSMARGVRKVFLRLLPQLL 355
           +N+         +    R V L+ + ++L
Sbjct: 321 MNIHFCGAEARPVPHWARVVILKYMSRVL 349


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  152 bits (383), Expect = 9e-37
 Identities = 120/398 (30%), Positives = 181/398 (45%), Gaps = 47/398 (11%)

Query: 119 DGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEI 178
           D  F+   + NVLV+  G   +LPP IF+S+C I V +FPFD Q+C L F S +Y    +
Sbjct: 29  DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88

Query: 179 DLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQ 238
           DLQ+ +           D   +  NGEW +   P K   +      +  +  V F + ++
Sbjct: 89  DLQMQE----------ADISGYIPNGEWDLVGIPGKR-SERFYECCKEPYPDVTFTVTMR 137

Query: 239 RKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPET 298
           R+ L+Y +N++ PCVLIS++A+L+  LPA + G+K ++ I VLL+ TVF+ LVA+ +P T
Sbjct: 138 RRTLYYGLNLLIPCVLISALALLVFLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPAT 196

Query: 299 SQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM- 357
           S +VPLI++Y    +++  L VV  V+VL      P    M +  R + L      LRM 
Sbjct: 197 SDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMK 256

Query: 358 -----HVRPLAPAAVQDTQSR---------------LQNGSSGWSITTGEEVALCLPRSE 397
                 VRP    A Q  Q R                 NG+  +    G +   C+P  +
Sbjct: 257 RPGEDKVRP----ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD 312

Query: 398 LLFQQWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSH 457
                    G+V   +       E  L    G   +  P +   +E    IA     Q  
Sbjct: 313 --------SGVVCGRMACSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDE 362

Query: 458 FDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495
            +    EW     V+DR+C +A     I  T GI + A
Sbjct: 363 SEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 400


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  146 bits (368), Expect = 5e-35
 Identities = 98/375 (26%), Positives = 183/375 (48%), Gaps = 20/375 (5%)

Query: 10  LLLLLAVCLGAQGRNQEER--------LLAD-LMQNYDPNLRPAERDSDVVNVSLKLTLT 60
           LL LL   L AQG  +  R         L+D L+ NY   +RP         VS+ + + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120
            +++++E+ + LTT +W    W D  L+W+P D++ +  L +P+  +W PDI++   VD 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD- 133

Query: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180
           V +      V +   G +    P    +ACS+ +  FPFD QNCSL F S  ++  +I++
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240
            L     +  E +  D   F   GEW +            +      + ++ FY++I+R+
Sbjct: 194 SL----WRLPEKVKSDRSVFMNQGEWEL--LGVLPYFREFSMESSNYYAEMKFYVVIRRR 247

Query: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300
           PLFYV++++ P + +  + I+  +LP  + G++ +  I +LL  +VFL +V+  +P T+ 
Sbjct: 248 PLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPATAI 306

Query: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR 360
             PLI  Y    + + ++ +   + ++ +  +      +   +R + L  +  LL +  +
Sbjct: 307 GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ 366

Query: 361 PLA---PAAVQDTQS 372
             +   PA  Q T++
Sbjct: 367 STSQRPPATSQATKT 381


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  144 bits (362), Expect = 3e-34
 Identities = 89/348 (25%), Positives = 172/348 (49%), Gaps = 11/348 (3%)

Query: 28  RLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRL 87
           RL   L+ NY   +RP         VS+ + +  +++++E+ + LTT +W    W D  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 88  RWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFR 147
           +W+P D++ +  L +P+  +W PDI++   VD V +      V +   G +    P    
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQVV 139

Query: 148 SACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWA 207
           +ACS+ +  FPFD QNCSL F S  ++  +I++ L     +  E +  D   F   GEW 
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWE 195

Query: 208 IQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPA 267
           +            +      + ++ FY++I+R+PLFYV++++ P + +  + I+  +LP 
Sbjct: 196 L--LGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPP 253

Query: 268 KAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVL 327
            + G++ +  I +LL  +VFL +V+  +P T+   PLI  Y    + + ++ +   + ++
Sbjct: 254 NS-GERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIV 312

Query: 328 NVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLA---PAAVQDTQS 372
            +  +      +   +R + L  +  LL +  +  +   PA  Q T++
Sbjct: 313 RLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 360


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  140 bits (353), Expect = 3e-33
 Identities = 90/307 (29%), Positives = 156/307 (50%), Gaps = 17/307 (5%)

Query: 10  LLLLLAVCLGAQGRNQEER--------LLAD-LMQNYDPNLRPAERDSDVVNVSLKLTLT 60
           LL LL   L AQG  +  R         L+D L+ NY   +RP         VS+ + + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120
            +++++E+ + LTT +W    W D  L+W+P D++ +  L +P+  +W PDI++   VD 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD- 133

Query: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180
           V +      V +   G +    P    +ACS+ +  FPFD QNCSL F S  ++  +I++
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240
            L     +  E +  D   F   GEW +            +      + ++ FY++I+R+
Sbjct: 194 SL----WRLPEKVKSDRSVFMNQGEWEL--LGVLPYFREFSMESSNYYAEMKFYVVIRRR 247

Query: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300
           PLFYV++++ P + +  + I+  +LP  + G++ +  I +LL  +VFL +V+  +P T+ 
Sbjct: 248 PLFYVVSLLLPSIFLMVMDIVGFYLPPNS-GERVSFKITLLLGYSVFLIIVSDTLPATAI 306

Query: 301 AVPLISK 307
             PLI K
Sbjct: 307 GTPLIGK 313


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  124 bits (312), Expect = 2e-28
 Identities = 83/301 (27%), Positives = 148/301 (49%), Gaps = 23/301 (7%)

Query: 42  RPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLR 101
           RP    S    V++   ++ ++ +NE+   L++ +W+EM W +  + W+P + EG+  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161
           + +  +W PDI +   +D V +        VS +G I +  P    S C++ + YFPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMD-VDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDP--EAFTENGEWAIQHRPAKMLLDP 219
           QNC+L F S  Y+ + + L + +E      W   D        +GEW +      + L  
Sbjct: 189 QNCTLTFSSFLYTVDSMLLDMEKE-----VWEITDASRNILQTHGEWEL------LGLSK 237

Query: 220 AAPAQEAG---HQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTV 276
           A      G   + ++VFY+ I+R+P  YVIN++ P   + ++  L  +LP K+ G +   
Sbjct: 238 ATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS-GNRVPF 296

Query: 277 AINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTF---LLVVTILIVVNAVVVLNVSLRS 333
            I +LL   VFL +++  +P  +   PLI  Y      L+V ++L  +    +L+V+   
Sbjct: 297 KITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQ 354

Query: 334 P 334
           P
Sbjct: 355 P 355


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  124 bits (312), Expect = 2e-28
 Identities = 81/299 (27%), Positives = 150/299 (50%), Gaps = 19/299 (6%)

Query: 42  RPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLR 101
           RP    S    V++  TL+ ++ ++ + + LT+ +W+++ W +  + W+P++  G+  L 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161
           V +  +W PDI +  ++D V +        +S +G I +  P    S C++ + YFPFD 
Sbjct: 115 VLAENLWLPDIFIVESMD-VDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAA 221
           QNC+  F S  Y+   +D  L   D +  E      +     GEW +      + ++ A 
Sbjct: 174 QNCTFTFSSFLYT---VDSMLLGMDKEVWEITDTSRKVIQTQGEWEL------LGINKAT 224

Query: 222 PAQEAG---HQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAI 278
           P    G   + +++FY+ I+R+P  Y+IN++ P   + ++  L  +LPA++   +    I
Sbjct: 225 PKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKI 283

Query: 279 NVLLAQTVFLFLVAKKVPETSQAVPLISKYLTF---LLVVTILIVVNAVVVLNVSLRSP 334
            +LL   VFL ++   +P  +   PLIS Y      L+VV++L  V    +L+V+   P
Sbjct: 284 TLLLGYNVFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQP 340


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  122 bits (305), Expect = 1e-27
 Identities = 79/301 (26%), Positives = 144/301 (47%), Gaps = 13/301 (4%)

Query: 29  LLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLR 88
           L   L+Q Y   +RP    +    V L L +  ++ ++   + L T+VW +  W D  L 
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 89  WDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRS 148
           W+   ++ +  + +P + +W PDI++   VD +        V V+  G I    P    S
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIIINEFVD-IERYPDLPYVYVNSSGTIENYKPIQVVS 153

Query: 149 ACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL--SQEDGQTIEWIFIDPEAFTENGEW 206
           ACS+    FPFD QNCSL F+S  ++  ++DL    S ED Q       D +AF  + EW
Sbjct: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQH------DKKAFLNDSEW 207

Query: 207 AIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLP 266
            +    +   +     +   G  ++ F ++++R PL YV++++ P + +  V +   +LP
Sbjct: 208 ELLSVSSTYSI---LQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLP 264

Query: 267 AKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVV 326
                 +     +VL+  TVF   ++ +VP +  + PLI  + T  +   +L +  ++V+
Sbjct: 265 PNCRA-RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVL 323

Query: 327 L 327
           +
Sbjct: 324 V 324


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  103 bits (256), Expect = 5e-22
 Identities = 92/321 (28%), Positives = 140/321 (43%), Gaps = 37/321 (11%)

Query: 196 DPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLI 255
           D   +  NGEW +   P K         +E  +  V F + ++R+ L+Y +N++ PCVLI
Sbjct: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCVLI 63

Query: 256 SSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVV 315
           S++A+L+  LPA +G +K ++ I VLL+ TVF+ LVA+ +P TS +VPLI++Y    +++
Sbjct: 64  SALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122

Query: 316 TILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM------HVRPLAPAAVQD 369
             L VV  V+VL      P    M +  R + L      LRM       VRP    A Q 
Sbjct: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP----ACQH 178

Query: 370 TQSR---------------LQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALE 414
            Q R                 NG+  +    G +   C+P  +         G+V   + 
Sbjct: 179 KQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD--------SGVVCGRMA 230

Query: 415 KLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDR 474
                 E  L    G   +  P +   +E    IA     Q   +    EW     V+DR
Sbjct: 231 CSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR 288

Query: 475 VCFLAMLSLFICGTAGIFLMA 495
           +C +A     I  T GI + A
Sbjct: 289 LCLMAFSVFTIICTIGILMSA 309


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 76/317 (23%), Positives = 134/317 (42%), Gaps = 19/317 (5%)

Query: 24  NQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWC 83
           N    +L  L+ +YDP +RP  +   V +V + + + +  S+ E       N+++  +W 
Sbjct: 54  NSTSNILNRLLVSYDPRIRPNFKGIPV-DVVVNIFINSFGSIQETTMDYRVNIFLRQKWN 112

Query: 84  DYRLRWDPRDYEGLWVLRVPSTM---VWRPDIVLENNVDGVFEVALYCNVL--VSPDGCI 138
           D RL+  P D+ G   L V  TM   +W+PD+   N     F      N+L  +  DG +
Sbjct: 113 DPRLKL-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDV 171

Query: 139 YWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPE 198
                     +C + +T FP D Q C +  +S  Y+T+  DL+   + G  ++   I   
Sbjct: 172 LVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTD--DLRFIWQSGDPVQLEKIALP 229

Query: 199 AFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL-FYVINIIAPCVLISS 257
            F    E        K         +  G+   V  +   R+ + FY++ + AP +LI  
Sbjct: 230 QFDIKKEDIEYGNCTKYY-------KGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVV 282

Query: 258 VAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTI 317
           ++ L  ++   A   +  + I  +L+       +A ++P+ S    L    +  LL    
Sbjct: 283 LSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFA 342

Query: 318 LIVVNAVVVLNVSLRSP 334
            +V  AVV   V L +P
Sbjct: 343 SLVEYAVV--QVMLNNP 357


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 70/310 (22%), Positives = 124/310 (40%), Gaps = 23/310 (7%)

Query: 8   LLLLLLLAVCLG-AQGRNQEE---------RLLADLMQNYDPNLRPAERDSDVVNVSLKL 57
           LL  L LAVCL  + G+NQ+E         R+L  L+  YD  LRP      V  V   +
Sbjct: 20  LLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGF-GGPVTEVKTDI 78

Query: 58  TLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENN 117
            +T+   +++ E   T +V+    W D RL++D    E L +  +  T VW PD    N 
Sbjct: 79  YVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDG-PIEILRLNNMMVTKVWTPDTFFRNG 137

Query: 118 VDGVFEVALYCNVL--VSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYST 175
              V       N L  +  +G I +       + C + +  FP D   C L F S  Y  
Sbjct: 138 KKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPK 197

Query: 176 NEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVV-FY 234
           +E+    ++   +++E          +     +Q+      +         G   V+  Y
Sbjct: 198 SEMIYTWTKGPEKSVE--------VPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249

Query: 235 LLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKK 294
             ++RK  +++I    PC++   ++ +  ++  ++   +    I  +L  T         
Sbjct: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309

Query: 295 VPETSQAVPL 304
           +P+ S A  +
Sbjct: 310 LPKVSYATAM 319


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 83/392 (21%), Positives = 159/392 (40%), Gaps = 43/392 (10%)

Query: 10  LLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNERE 69
           ++L L  C         +++L  ++  YD  LRP    + V  V + + +T++  ++E  
Sbjct: 43  VVLNLFNCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVP-VRISIYVTSIEQISEMN 101

Query: 70  EALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTM---VWRPDIVLENNVDG-VFEVA 125
              T  ++    W D RL +    YE    L +   M   +W PD    N+ D  V +V 
Sbjct: 102 MDYTITMFFHQTWKDSRLAY----YETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVT 157

Query: 126 LYCNVL-VSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQ 184
           +   V  + PDG + +       +ACS+ +  FP D Q C+L+ +S  Y+  +I L    
Sbjct: 158 VENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIIL-FWD 216

Query: 185 EDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQE-----AGHQKVVFYLLIQR 239
           ++G  I          TE       H P    L     ++E       + +++    +QR
Sbjct: 217 DNGNAIH--------MTEE-----LHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQR 263

Query: 240 KPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETS 299
           +   Y++ +  P VL +  + +  ++   +   + T+ +  +L  T     +  K+P  S
Sbjct: 264 EVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNIS 323

Query: 300 --QAVPLISKYLTFLLVVTIL--IVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLL 355
             +A+ +      F + +++L  + +N +       R P  H   R V          + 
Sbjct: 324 CIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRV----------IA 373

Query: 356 RMHVRPLAPAAVQDTQSRLQNGSSGWSITTGE 387
           R   + +    VQD    +++G S   IT  +
Sbjct: 374 RYRYQQVVVGNVQDGLINVEDGVSSLPITPAQ 405


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 60/284 (21%), Positives = 118/284 (41%), Gaps = 21/284 (7%)

Query: 28  RLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRL 87
           R+L  L+  YD  LRP   +  V  V   + +T+   +++ +   T +V+    W D RL
Sbjct: 44  RILDRLLDGYDNRLRPGLGER-VTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102

Query: 88  RWDPRDYEG-LWVLRVPSTM---VWRPDIVLENNVDGVFEVALYCNVL--VSPDGCIYWL 141
           +     ++G + VLR+ + M   +W PD    N    V       N L  ++ DG + + 
Sbjct: 103 K-----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157

Query: 142 PPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFT 201
                R+ C + +  FP D   C L F S  Y+  E+  + ++E  +++           
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSV--------VVA 209

Query: 202 ENGEWAIQHRPAKMLLDPAAPAQEAGHQKVV-FYLLIQRKPLFYVINIIAPCVLISSVAI 260
           E+G    Q+      +D        G   V+  +  ++RK  ++VI    PC++   ++ 
Sbjct: 210 EDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQ 269

Query: 261 LIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPL 304
           +  +L  ++   +    +  +L  T         +P+ + A  +
Sbjct: 270 VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAM 313


>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 60/284 (21%), Positives = 118/284 (41%), Gaps = 21/284 (7%)

Query: 28  RLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRL 87
           R+L  L+  YD  LRP   +  V  V   + +T+   +++ +   T +V+    W D RL
Sbjct: 44  RILDRLLDGYDNRLRPGLGER-VTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERL 102

Query: 88  RWDPRDYEG-LWVLRVPSTM---VWRPDIVLENNVDGVFEVALYCNVL--VSPDGCIYWL 141
           +     ++G + VLR+ + M   +W PD    N    V       N L  ++ DG + + 
Sbjct: 103 K-----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157

Query: 142 PPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFT 201
                R+ C + +  FP D   C L F S  Y+  E+  + ++E  +++           
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSV--------VVA 209

Query: 202 ENGEWAIQHRPAKMLLDPAAPAQEAGHQKVV-FYLLIQRKPLFYVINIIAPCVLISSVAI 260
           E+G    Q+      +D        G   V+  +  ++RK  ++VI    PC++   ++ 
Sbjct: 210 EDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQ 269

Query: 261 LIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPL 304
           +  +L  ++   +    +  +L  T         +P+ + A  +
Sbjct: 270 VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAM 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,564,479
Number of Sequences: 37866
Number of extensions: 907576
Number of successful extensions: 2844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2639
Number of HSP's gapped (non-prelim): 99
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.