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Search of human proteins with 61742786
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61742786 leucine rich repeat and death domain containing
protein isoform 3 [Homo sapiens]
(893 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61742786 leucine rich repeat and death domain containing prot... 1785 0.0
gi|61742784 leucine rich repeat and death domain containing prot... 1774 0.0
gi|61742782 leucine rich repeat and death domain containing prot... 1456 0.0
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 116 8e-26
gi|45827729 scribble isoform b [Homo sapiens] 116 1e-25
gi|45827731 scribble isoform a [Homo sapiens] 116 1e-25
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 112 2e-24
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 112 2e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 111 3e-24
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 110 8e-24
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 109 1e-23
gi|4503743 flightless I homolog [Homo sapiens] 108 2e-23
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 108 2e-23
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 108 2e-23
gi|40217803 leucine rich repeat containing 8 family, member E [H... 105 2e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 102 2e-21
gi|62241040 leucine rich repeat containing 8 family, member A [H... 100 8e-21
gi|187829877 leucine rich repeat containing 8 family, member A [... 100 8e-21
gi|187829871 leucine rich repeat containing 8 family, member A [... 100 8e-21
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 99 1e-20
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 99 2e-20
gi|19923729 leucine rich repeat containing 8 family, member C [H... 97 9e-20
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 96 1e-19
gi|197333692 leucine rich repeat containing 8 family, member B [... 96 2e-19
gi|21245134 leucine rich repeat containing 8 family, member B [H... 96 2e-19
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 96 2e-19
gi|238908508 leucine-rich repeat and death domain-containing pro... 94 4e-19
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 93 1e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 92 2e-18
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 92 2e-18
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 1785 bits (4623), Expect = 0.0
Identities = 893/893 (100%), Positives = 893/893 (100%)
Query: 1 MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ
Sbjct: 1 MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
Query: 61 LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG
Sbjct: 61 LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
Query: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
Query: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
Query: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS
Sbjct: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
Query: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF
Sbjct: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
Query: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS
Sbjct: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
Query: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV
Sbjct: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
Query: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV
Sbjct: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
Query: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVSFYRGAVPVRVPEEAE 720
EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVSFYRGAVPVRVPEEAE
Sbjct: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVSFYRGAVPVRVPEEAE 720
Query: 721 AARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAG 780
AARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAG
Sbjct: 721 AARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAG 780
Query: 781 RLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQAL 840
RLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQAL
Sbjct: 781 RLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQAL 840
Query: 841 EQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 893
EQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 841 EQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 893
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 1774 bits (4595), Expect = 0.0
Identities = 893/910 (98%), Positives = 893/910 (98%), Gaps = 17/910 (1%)
Query: 1 MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ
Sbjct: 1 MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
Query: 61 LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG
Sbjct: 61 LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
Query: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
Query: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
Query: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS
Sbjct: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
Query: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF
Sbjct: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
Query: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS
Sbjct: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
Query: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV
Sbjct: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
Query: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV
Sbjct: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
Query: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKE----------------- 703
EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKE
Sbjct: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQ 720
Query: 704 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 763
VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG
Sbjct: 721 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 780
Query: 764 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 823
DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA
Sbjct: 781 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 840
Query: 824 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 883
ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS
Sbjct: 841 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 900
Query: 884 APQPPEPAQA 893
APQPPEPAQA
Sbjct: 901 APQPPEPAQA 910
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 1456 bits (3770), Expect = 0.0
Identities = 736/764 (96%), Positives = 736/764 (96%), Gaps = 28/764 (3%)
Query: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 267 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 326
RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
Query: 327 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 386
PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH
Sbjct: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240
Query: 387 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 446
GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS
Sbjct: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300
Query: 447 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 506
WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL
Sbjct: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360
Query: 507 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 566
LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD
Sbjct: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420
Query: 567 ITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 626
ITAQVVLELTHL YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD
Sbjct: 421 ITAQVVLELTHL-----------YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 469
Query: 627 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 686
PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV
Sbjct: 470 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 529
Query: 687 EGRICFVFYSHLKNVKE-----------------VSFYRGAVPVRVPEEAEAARQRKGAD 729
EGRICFVFYSHLKNVKE VSFYRGAVPVRVPEEAEAARQRKGAD
Sbjct: 530 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 589
Query: 730 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 789
ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV
Sbjct: 590 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 649
Query: 790 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 849
ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA
Sbjct: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 709
Query: 850 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 893
EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 710 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 116 bits (291), Expect = 8e-26
Identities = 78/188 (41%), Positives = 107/188 (56%), Gaps = 8/188 (4%)
Query: 114 LTNLPAGLS---GLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
L + P G + L+ + DLS N +P Q+ L L L HNCL L ALG L
Sbjct: 54 LKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNL 113
Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
ALT+L ++ N+L LPP + L L+ L +S N L LPP+IG LGSL +L+++SN LQ
Sbjct: 114 TALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQ 172
Query: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLDAPF 287
SLP+ L GL SLR L + N L+++P +L LPL+ RLD N++ +P L
Sbjct: 173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLDFSCNRVSRIPVSFCRLRHLQV 231
Query: 288 VRLQGNPL 295
+ L NPL
Sbjct: 232 ILLDSNPL 239
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/200 (35%), Positives = 104/200 (52%), Gaps = 28/200 (14%)
Query: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
CL AL NL A L +L+LS N L LP + Q+ L L++S+N L LP +G
Sbjct: 105 CLNPALGNLTA-------LTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIG 156
Query: 169 ALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNR 228
L +L L V+ N LQ+LP L LS+L+ L++ +N L TLP E+G L L+ L+ + NR
Sbjct: 157 TLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNR 215
Query: 229 LQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLTRLDLRDNQLRDLPPELLDA 285
+ +P S LR L++++L SN L S PA + +L + L Q
Sbjct: 216 VSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQ----------- 264
Query: 286 PFVRLQGNPLGEASPDAPSS 305
+G+ LG+ +P P S
Sbjct: 265 -----RGSALGDLAPSRPPS 279
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 116 bits (290), Expect = 1e-25
Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)
Query: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
PL L F +L + L + +L LP + L +LV + R+ L L +L
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
PA LS L L LDL N LE LP + + L L L N LS LP LG L L L
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
V+ NRL+ LP LG L L L LSQNLL LP IG L L L + NRL + ++
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
+L L+L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 115 bits (287), Expect = 2e-25
Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)
Query: 35 GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
GN LS P G QL HL + LQ L + L+ +L E L LP SLS
Sbjct: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
Query: 91 CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
L L L G DTLGA R L+ LP L L L LD+S N
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
Query: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
LE LPA + + L LLLS N L LP+ +G L L+ L V NRL + A+G L
Sbjct: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
Query: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
L L++NLL LP +G L L LN+ N L++LP + G +L +L L N LA +P
Sbjct: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
Query: 257 ADLARLPLLTRLDLRDNQLRDLP 279
+LA L LD+ N+L+ LP
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLP 374
Score = 106 bits (265), Expect = 8e-23
Identities = 69/171 (40%), Positives = 95/171 (55%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L+ LP G + L LAHL L+ SL+ LP V + L L L N L LP +L L L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N L+ LP LGAL L+ L L +N L LPPE+G L L+ L+++ NRL+ LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
A L GL L L+L NLL +P + +L L+ L + N+L ++ + D
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 103 bits (258), Expect = 5e-22
Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)
Query: 28 RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
R+L L N +SL PG L +L + + L+++E L L + D
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
Query: 76 QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
++L TL LP LR L L G RR L LPA L GL
Sbjct: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
L L LS N L LP + Q++ L L + N L E+ EA+G L+ L +T N L
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
LP +LG L+ L L++ +N L+ LPPEIGG +L L+L NRL LP LA L +
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
L + N L S+P L L L L L +NQ + +
Sbjct: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)
Query: 59 LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
LQ + E R S + LL+A L +LP+ L +L G + + L
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
P ++ L LD+S N + +P + + L S N LS LP+ L +L L
Sbjct: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
+ LQ LP +G L+ L L+L +NLL +LP + L L +L+L N L+ LP +L
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L +LR L L N L+++P +L L L LD+ +N+L +LP EL
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
Score = 97.8 bits (242), Expect = 4e-20
Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)
Query: 59 LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
L+ L F RL L + + +LP ++ LV R D + +P
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
Query: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
+ L D S N L LP Q+R L L L+ L LP +G L L L +
Sbjct: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
Query: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
N L++LP +L L L++LDL N L+ LP +G L +L EL L N+L +LP L
Sbjct: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
Query: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
LR L L + N L +PA+L L LLT L L N LR LP
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Score = 77.8 bits (190), Expect = 4e-14
Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N L LP ++ L L LS N + LP + L L V+ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P ++ L+ D S N L LP L SL L L LQ+LP + L +L L
Sbjct: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
L NLL S+PA L+ L L +LDL N L LP L P +R L N L P+
Sbjct: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 116 bits (290), Expect = 1e-25
Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)
Query: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
PL L F +L + L + +L LP + L +LV + R+ L L +L
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
PA LS L L LDL N LE LP + + L L L N LS LP LG L L L
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
V+ NRL+ LP LG L L L LSQNLL LP IG L L L + NRL + ++
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
+L L+L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 115 bits (287), Expect = 2e-25
Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)
Query: 35 GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
GN LS P G QL HL + LQ L + L+ +L E L LP SLS
Sbjct: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
Query: 91 CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
L L L G DTLGA R L+ LP L L L LD+S N
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
Query: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
LE LPA + + L LLLS N L LP+ +G L L+ L V NRL + A+G L
Sbjct: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
Query: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
L L++NLL LP +G L L LN+ N L++LP + G +L +L L N LA +P
Sbjct: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
Query: 257 ADLARLPLLTRLDLRDNQLRDLP 279
+LA L LD+ N+L+ LP
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLP 374
Score = 106 bits (265), Expect = 8e-23
Identities = 69/171 (40%), Positives = 95/171 (55%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L+ LP G + L LAHL L+ SL+ LP V + L L L N L LP +L L L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N L+ LP LGAL L+ L L +N L LPPE+G L L+ L+++ NRL+ LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
A L GL L L+L NLL +P + +L L+ L + N+L ++ + D
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 103 bits (258), Expect = 5e-22
Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)
Query: 28 RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
R+L L N +SL PG L +L + + L+++E L L + D
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
Query: 76 QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
++L TL LP LR L L G RR L LPA L GL
Sbjct: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
L L LS N L LP + Q++ L L + N L E+ EA+G L+ L +T N L
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
LP +LG L+ L L++ +N L+ LPPEIGG +L L+L NRL LP LA L +
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
L + N L S+P L L L L L +NQ + +
Sbjct: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)
Query: 59 LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
LQ + E R S + LL+A L +LP+ L +L G + + L
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
P ++ L LD+S N + +P + + L S N LS LP+ L +L L
Sbjct: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
+ LQ LP +G L+ L L+L +NLL +LP + L L +L+L N L+ LP +L
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L +LR L L N L+++P +L L L LD+ +N+L +LP EL
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
Score = 97.8 bits (242), Expect = 4e-20
Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)
Query: 59 LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
L+ L F RL L + + +LP ++ LV R D + +P
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
Query: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
+ L D S N L LP Q+R L L L+ L LP +G L L L +
Sbjct: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
Query: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
N L++LP +L L L++LDL N L+ LP +G L +L EL L N+L +LP L
Sbjct: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
Query: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
LR L L + N L +PA+L L LLT L L N LR LP
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Score = 77.8 bits (190), Expect = 4e-14
Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N L LP ++ L L LS N + LP + L L V+ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P ++ L+ D S N L LP L SL L L LQ+LP + L +L L
Sbjct: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
L NLL S+PA L+ L L +LDL N L LP L P +R L N L P+
Sbjct: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 112 bits (279), Expect = 2e-24
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
P G QLL+L L+ L F RL+ + +L E L LP++++ L L
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
Query: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
VL+ G + + A LT +P + L L +LD+S N++E +
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
Query: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
+ L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
Query: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ +
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
Query: 263 PLLTRLDLRDNQLRDLP 279
L ++L DN+L++LP
Sbjct: 368 QKLKVINLSDNRLKNLP 384
Score = 90.1 bits (222), Expect = 8e-18
Identities = 55/169 (32%), Positives = 85/169 (50%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
S+ GL S+ L N + ++P+ + +L L N L+ LPPE+
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
Score = 82.8 bits (203), Expect = 1e-15
Identities = 54/162 (33%), Positives = 81/162 (50%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
L L L+ + +N L +P + L LT LD+ N +
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
Score = 76.3 bits (186), Expect = 1e-13
Identities = 53/169 (31%), Positives = 83/169 (49%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N +P L LS L+ + N L +P IG L L L+++ N ++ +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
++ +L+ L+L SN L +P + L +T L + +NQL LP +
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 73.2 bits (178), Expect = 1e-12
Identities = 54/166 (32%), Positives = 74/166 (44%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ LP L L L L N L TLPA + + L L +S N + E PE + L
Sbjct: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
++ L L L L SN VP L +L L + N+L +P
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/156 (32%), Positives = 74/156 (47%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P + L ++ S N + LP L +L +L L L+ LPA+ L L++L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L N L +P + RL L RLDL N+ ++P L
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
N L ++PA +A L L LD+ N +++ P +
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 112 bits (279), Expect = 2e-24
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
P G QLL+L L+ L F RL+ + +L E L LP++++ L L
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
Query: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
VL+ G + + A LT +P + L L +LD+S N++E +
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
Query: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
+ L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
Query: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ +
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
Query: 263 PLLTRLDLRDNQLRDLP 279
L ++L DN+L++LP
Sbjct: 368 QKLKVINLSDNRLKNLP 384
Score = 90.1 bits (222), Expect = 8e-18
Identities = 55/169 (32%), Positives = 85/169 (50%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
S+ GL S+ L N + ++P+ + +L L N L+ LPPE+
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
Score = 82.8 bits (203), Expect = 1e-15
Identities = 54/162 (33%), Positives = 81/162 (50%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
L L L+ + +N L +P + L LT LD+ N +
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
Score = 76.3 bits (186), Expect = 1e-13
Identities = 53/169 (31%), Positives = 83/169 (49%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N +P L LS L+ + N L +P IG L L L+++ N ++ +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
++ +L+ L+L SN L +P + L +T L + +NQL LP +
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 73.2 bits (178), Expect = 1e-12
Identities = 54/166 (32%), Positives = 74/166 (44%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ LP L L L L N L TLPA + + L L +S N + E PE + L
Sbjct: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
++ L L L L SN VP L +L L + N+L +P
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/156 (32%), Positives = 74/156 (47%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P + L ++ S N + LP L +L +L L L+ LPA+ L L++L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L N L +P + RL L RLDL N+ ++P L
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
N L ++PA +A L L LD+ N +++ P +
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 111 bits (277), Expect = 3e-24
Identities = 80/221 (36%), Positives = 112/221 (50%), Gaps = 14/221 (6%)
Query: 76 QLLEATLAQLPQSLSCLRSLV-LKGGQRR-----DTLGACLR--------GALTNLPAGL 121
+L E L LP SL+ LR L L G +++GA L L+ LP +
Sbjct: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Query: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
L +L LD+S N LE LP + + L L++S N L +P+ +G L L+ L V N
Sbjct: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276
Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
RL LP A+G +L L L++N L TLP IG L L LN N+L SLP + G S
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L + + N L +PA++++ L LD+ N+L LP L
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
Score = 109 bits (272), Expect = 1e-23
Identities = 80/225 (35%), Positives = 114/225 (50%), Gaps = 9/225 (4%)
Query: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
PL L F L + + +L LP+++ L +L + R+ L LT L
Sbjct: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL--ELRENL-------LTYL 166
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
P L+ L L LDL N + LP + + L L L N LSELP+ +G L L L
Sbjct: 167 PDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLD 226
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
V+ NRL+ LP + L++L L +SQNLL+T+P IG L L L + NRL LP ++
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVG 286
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
SL LVL N L ++P + +L L+ L+ N+L LP E+
Sbjct: 287 ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
Score = 106 bits (264), Expect = 1e-22
Identities = 78/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)
Query: 82 LAQLPQSLSCLRSLVLKGGQRRDTLGACL---RGALTNLPAGLSGLAHLAHLDLSFNSLE 138
L++LPQ + L++L+ CL L LP +SGL L L +S N LE
Sbjct: 209 LSELPQEIGNLKNLL------------CLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
Query: 139 TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR 198
T+P + +++ L L + N L++LPEA+G +LT L +T N+L TLP ++G L L
Sbjct: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
Query: 199 LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPAD 258
L+ +N L +LP EIGG SL + NRL +PA ++ L +L + N L +P
Sbjct: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLS 376
Query: 259 LARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSP 306
L L L L L DNQ + L D + + P PS P
Sbjct: 377 LTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
Score = 95.5 bits (236), Expect = 2e-19
Identities = 59/169 (34%), Positives = 89/169 (52%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ LP ++ L LD+S N + +P + + L S N L+ LPE+ L L
Sbjct: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T L+V LQ+LP +G L L L+L +NLL LP + L L EL+L +N + +LP
Sbjct: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
S+ L L+ L L N L+ +P ++ L L LD+ +N+L LP E+
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
Score = 88.2 bits (217), Expect = 3e-17
Identities = 74/247 (29%), Positives = 111/247 (44%), Gaps = 40/247 (16%)
Query: 56 QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALT 115
+Q QL+++ L LS +E + +LP ++ LV R + +
Sbjct: 53 EQFFQLVKLRKLGLSDNE--------IQRLPPEIANFMQLVELDVSRNE---------IP 95
Query: 116 NLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTF 175
+P +S L D S N L LP +++ L L ++ L LPE +G L L
Sbjct: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
Query: 176 LTVTHNRLQTLPPALGALSTLQRLDLSQ-----------------------NLLDTLPPE 212
L + N L LP +L L L+ LDL N L LP E
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 213 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 272
IG L +LL L+++ NRL+ LP ++GL SL LV+ NLL ++P + +L L+ L +
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275
Query: 273 NQLRDLP 279
N+L LP
Sbjct: 276 NRLTQLP 282
Score = 80.1 bits (196), Expect = 8e-15
Identities = 59/169 (34%), Positives = 80/169 (47%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L LP L L L LS N ++ LP + L L +S N + E+PE++ AL
Sbjct: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
+ N L LP + L L L ++ L +LP IG L +L L L N L LP
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
SL LR L L L +N + ++P + L L L L NQL +LP E+
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/174 (34%), Positives = 81/174 (46%), Gaps = 3/174 (1%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N L LP Q+ L L LS N + LP + L L V+ N + +
Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P ++ LQ D S N L LP L +L L++ LQSLP ++ L +L L
Sbjct: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE---LLDAPFVRLQGNPLGE 297
L NLL +P L +L L LDL +N++ +LP LL + L GN L E
Sbjct: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
Score = 73.9 bits (180), Expect = 6e-13
Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)
Query: 126 HLAHLDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
H+ +D SL +P + + R L LLL N L ELPE L L L ++ N +Q
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
LPP + L LD+S+N + +P I +L + + N L LP S L++L
Sbjct: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L ++ L S+P ++ L L L+LR+N L LP L
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 110 bits (274), Expect = 8e-24
Identities = 91/250 (36%), Positives = 122/250 (48%), Gaps = 44/250 (17%)
Query: 79 EATLAQLPQSLSCLRS-LVLKGGQRRDTLGACLR-----GALTNLPAGL-SGLAHLAHLD 131
E ++L S L S L +G +RR A LR L +LP L SG HL LD
Sbjct: 15 ELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLD 74
Query: 132 LSFNSLETLPACVLQMRGLGALL-----------------------------LSHNCLSE 162
+S N+L L +L +RGL LL LS NC E
Sbjct: 75 VSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQE 134
Query: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
+P +L L AL L++ N+LQ++P + L +L+ L L N + +PPE+G L SL L
Sbjct: 135 VPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYL 194
Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL-----RD 277
L N++QS+P L+ L SLR L LH+NLL +P ++ L L L LR N L RD
Sbjct: 195 VLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRD 254
Query: 278 L---PPELLD 284
L PP LL+
Sbjct: 255 LTYDPPTLLE 264
Score = 78.6 bits (192), Expect = 2e-14
Identities = 68/171 (39%), Positives = 88/171 (51%), Gaps = 12/171 (7%)
Query: 128 AHLDLSFNSLET-LPACVLQMRG----LGALLLSHNCLSELPEALGA-LPALTFLTVTHN 181
+ L +S +LE+ L A + RG L LLL HN L LP ALG+ P L L V+ N
Sbjct: 19 SRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGN 78
Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------SLLELNLASNRLQSLPAS 235
L L P L AL L+ L N L GL SL LNL+ N Q +PAS
Sbjct: 79 ALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPAS 138
Query: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
L LR+L+ L L N L S+PA++ L L L L N ++++PPEL + P
Sbjct: 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 109 bits (273), Expect = 1e-23
Identities = 103/317 (32%), Positives = 147/317 (46%), Gaps = 31/317 (9%)
Query: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL--VL 97
P G QLL+L L+ L F RL +L E L LP+S+ L L +
Sbjct: 131 PDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLD 190
Query: 98 KGGQRRDTLGACL------------RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL 145
G L L AL LP + L L +LD+S N +ET+ +
Sbjct: 191 LGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250
Query: 146 QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNL 205
L LLLS N L +LP+++G L LT L V N+L LP +G LS L+ D S N
Sbjct: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE 310
Query: 206 LDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
L++LP IG L SL L + N L LP + +++ ++ L SN L +P ++ ++ L
Sbjct: 311 LESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKL 370
Query: 266 TRLDLRDNQLRDLP---PELLDAPFVRLQGN------PL-GEASPDAPSSPVA-ALIPEM 314
L+L DN+L++LP +L + + L N PL EA P+ + + P+
Sbjct: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQ 430
Query: 315 PR--LFLTSDLDSFPVT 329
PR SD DSF T
Sbjct: 431 PRGDEDFQSDSDSFNPT 447
Score = 91.3 bits (225), Expect = 4e-18
Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 10/234 (4%)
Query: 47 CQQLLHLCV-QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
CQ L L + L L L ++ + + + + P+++ C + L T
Sbjct: 68 CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL---------T 118
Query: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
+ ++ LP G + L +L L L+ LE LPA ++ L L L N L LP+
Sbjct: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
Query: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLA 225
++ L L L + +N LP L + L+ L + N L LP IG L L+ L+++
Sbjct: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
Query: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
NR++++ ++G +L L+L SN+L +P + L LT L + DNQL LP
Sbjct: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
Score = 84.3 bits (207), Expect = 4e-16
Identities = 53/169 (31%), Positives = 89/169 (52%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L+NLP ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 81 LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T L + L+ LP G L L+ L+L +N L TLP + L L L+L +N LP
Sbjct: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP 200
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L +++LR L + +N L +P + +L +L LD+ N++ + ++
Sbjct: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDI 249
Score = 75.9 bits (185), Expect = 2e-13
Identities = 53/158 (33%), Positives = 79/158 (50%), Gaps = 1/158 (0%)
Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
L L L N +E LP + + L L + N LS LP + +L L L ++ N +Q
Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
P + L ++ S N + LP L +L +L L L+ LPA+ L LR+L
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
L N L ++P + +L L RLDL +N+ +L PE+LD
Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGEL-PEVLD 204
Score = 73.9 bits (180), Expect = 6e-13
Identities = 52/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)
Query: 130 LDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
LD S SL+ +P V R L L L N + ELP+ L AL L++ N L LP
Sbjct: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
Query: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
+ +L L+ LD+S+N + P I L + + N + LP L +L L L+
Sbjct: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
Query: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L +PA+ RL L L+LR+N L+ LP +
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
Score = 71.2 bits (173), Expect = 4e-12
Identities = 51/166 (30%), Positives = 74/166 (44%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ LP L L L + N L LP + + L L +S N + E PE + L
Sbjct: 58 IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
T + + N + LP L L +L L+ L+ LP G L L L L N L++LP
Sbjct: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 177
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
S+ L L L L +N +P L ++ L L + +N L+ LP
Sbjct: 178 KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 108 bits (270), Expect = 2e-23
Identities = 80/229 (34%), Positives = 122/229 (53%), Gaps = 13/229 (5%)
Query: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
P Q+ ++ L+ LL A L QLP +++ L++L L+ QR + NL
Sbjct: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMTALQTLHLRSTQRTQS----------NL 215
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
P L GL++LA +DLS N L +P C+ + L L LS N ++EL + + L
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPAS 235
++ N+L +LP A+ LS L++L L+ N L D LP IG L +L E A+N L+ +P S
Sbjct: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
Query: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
L LR LVL+ N L ++P + L + LD+R+N +PP+ D
Sbjct: 336 LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 82.8 bits (203), Expect = 1e-15
Identities = 98/332 (29%), Positives = 147/332 (44%), Gaps = 33/332 (9%)
Query: 5 VEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQV 64
V G +L G ++ +L +L NR L P L Q L+ L V
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPE------ELAALQKLEHLSV 63
Query: 65 EFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGL 124
L+T L L+ LP LR++V + +++ +P + L
Sbjct: 64 SHNNLTT------LHGELSSLPS----LRAIVARANSLKNS----------GVPDDIFKL 103
Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA-LPALTFLTVTHNRL 183
L+ LDLS N L P + + + L LSHN + +P L L L +L ++ NRL
Sbjct: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRL 163
Query: 184 QTLPPALGALSTLQRLDLSQN-LLDTLPPEIGGLGSLLELNLAS-NRLQS-LPASLAGLR 240
++LPP + L LQ L L+ N LL ++ + +L L+L S R QS LP SL GL
Sbjct: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLS 223
Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
+L + L N L VP L LP L RL+L NQ+ +L L +V ++ L
Sbjct: 224 NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL--SLCIDQWVHVETLNLSRNQL 281
Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQG 332
+ S + L ++ +L+L S+ F P G
Sbjct: 282 TSLPSAICKL-SKLKKLYLNSNKLDFDGLPSG 312
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/125 (35%), Positives = 70/125 (56%), Gaps = 4/125 (3%)
Query: 165 EALGALPALTFLTVTHNRLQT--LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
EA G LP + + ++ N + P + A+++L+ L L++ L LP E+ L L L
Sbjct: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61
Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLL--ASVPADLARLPLLTRLDLRDNQLRDLPP 280
+++ N L +L L+ L SLR +V +N L + VP D+ +L L+ LDL NQL + P
Sbjct: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
Query: 281 ELLDA 285
EL +A
Sbjct: 122 ELENA 126
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 108 bits (270), Expect = 2e-23
Identities = 78/250 (31%), Positives = 124/250 (49%), Gaps = 21/250 (8%)
Query: 36 NRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL 95
N + LDL ++ +H+ +L Q+ L L +++ L LP + CL +L
Sbjct: 101 NSMRLDL----SKRSIHILPSSIKELTQLTELYLYSNK--------LQSLPAEVGCLVNL 148
Query: 96 VLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLL 155
+ TL A +LT+LP L L L LDL N L +P+ V ++ L L L
Sbjct: 149 M--------TL-ALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL 199
Query: 156 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 215
N ++ + + + L L+ L++ N+++ LP +G L L LD++ N L+ LP EIG
Sbjct: 200 RFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
Query: 216 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
+ L+L N L LP ++ L SL L L N L+++P LA+ L L+L +N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
Query: 276 RDLPPELLDA 285
LP LL +
Sbjct: 320 STLPESLLSS 329
Score = 95.9 bits (237), Expect = 1e-19
Identities = 65/186 (34%), Positives = 97/186 (52%), Gaps = 7/186 (3%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT+LP + L+L+ N L +P V + L L+LS+N L +LP LG L L
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL 450
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N+L++LP + L LQ+L L+ N L TLP IG L +L L L N L LP
Sbjct: 451 RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLP 510
Query: 234 ASLAGLRSLRLLVLHSNL-LASVPADLARLPLLTRLDLRDNQLRDLPPELLDA------P 286
+ L +L L L+ N L S+P +LA L+ + + + L LPP+++
Sbjct: 511 EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQ 570
Query: 287 FVRLQG 292
F+++QG
Sbjct: 571 FLKMQG 576
Score = 89.4 bits (220), Expect = 1e-17
Identities = 62/171 (36%), Positives = 93/171 (54%), Gaps = 2/171 (1%)
Query: 114 LTNLPAGLSGLAH-LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPA 172
+ +P G+ A L+ L++ N L +LP + L L+ N L+++PE + L +
Sbjct: 367 INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426
Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
L L +++N L+ LP LG L L+ LDL +N L++LP EI L L +L L +N+L +L
Sbjct: 427 LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTL 486
Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
P + L +L L L NLL +P ++ L L L L DN L LP EL
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFEL 537
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 108 bits (270), Expect = 2e-23
Identities = 68/166 (40%), Positives = 94/166 (56%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L +L L L L LD+ N L +LP+ + ++ L L +SHN L LPE + L L
Sbjct: 94 LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNL 153
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + HN L + LS L+ LDLS N L T+P L SL+ LNL+SN L+SLP
Sbjct: 154 KCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLP 213
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
A + ++ L+ L +SNLL ++P +LA + L L LR N+LR LP
Sbjct: 214 AEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Score = 90.1 bits (222), Expect = 8e-18
Identities = 66/192 (34%), Positives = 95/192 (49%), Gaps = 24/192 (12%)
Query: 115 TNLPAGLSGLAHLA-HLDLSFNSLETLPACVLQMR-----------------------GL 150
T++P GL A + L+LS +L +P CV ++ L
Sbjct: 25 TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDL 84
Query: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
L++S+N L L + L LPALT L + N+L +LP A+ L LQ+L++S N L LP
Sbjct: 85 TKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILP 144
Query: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
EI L +L L L N L + L +L L L +N L +VPA + L L RL+L
Sbjct: 145 EEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNL 204
Query: 271 RDNQLRDLPPEL 282
N+L+ LP E+
Sbjct: 205 SSNELKSLPAEI 216
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/197 (32%), Positives = 103/197 (52%), Gaps = 3/197 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT +PA S L+ L L+LS N L++LPA + +M+ L L + N L +P L + +L
Sbjct: 186 LTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSL 232
L + N+L+ LP + S L+ L + +N ++ L E + L S+L L+L N+L+S+
Sbjct: 246 ELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQG 292
P + LRSL L L +N ++S+P L L L L L N LR + E++ +
Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
Query: 293 NPLGEASPDAPSSPVAA 309
+ D PS +A
Sbjct: 364 YLRSKIKDDGPSQSESA 380
Score = 78.2 bits (191), Expect = 3e-14
Identities = 70/195 (35%), Positives = 98/195 (50%), Gaps = 12/195 (6%)
Query: 66 FLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLA 125
F +LS ED L L +P S S L SLV R L + L +LPA ++ +
Sbjct: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSLV------RLNLSS---NELKSLPAEINRMK 220
Query: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
L HLD + N LET+P + M L L L N L LPE + L L V N+++
Sbjct: 221 RLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEM 279
Query: 186 LPPA-LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
L L L+++ LDL N L ++P EI L SL L+L++N + SLP SL L L+
Sbjct: 280 LEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKF 338
Query: 245 LVLHSNLLASVPADL 259
L L N L ++ ++
Sbjct: 339 LALEGNPLRTIRREI 353
Score = 69.7 bits (169), Expect = 1e-11
Identities = 49/144 (34%), Positives = 78/144 (54%), Gaps = 5/144 (3%)
Query: 156 SHNCLSELPEALGALPALTF-LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 214
S N L E+P+ + L + + ++ N+L + L L L LDL N L++LP E+
Sbjct: 433 SKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME 492
Query: 215 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDN 273
L L +NL+ NR + LP L + +L +++ +N + SV P + + LT LDL++N
Sbjct: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
Query: 274 QLRDLPPELLDAPFVR---LQGNP 294
L +PPEL + +R L GNP
Sbjct: 553 DLLQIPPELGNCVNLRTLLLDGNP 576
Score = 60.8 bits (146), Expect = 5e-09
Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 5/127 (3%)
Query: 127 LAHLDLSFNSLE--TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
++ +DLSFN L +L CVLQ L L L +N L+ LPE + +L L + ++ NR +
Sbjct: 451 VSDVDLSFNKLSFISLELCVLQK--LTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
LP L + TL+ + +S N + ++ P+ + + +L L+L +N L +P L +LR
Sbjct: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
Query: 244 LLVLHSN 250
L+L N
Sbjct: 569 TLLLDGN 575
Score = 47.0 bits (110), Expect = 8e-05
Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 1/105 (0%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L LDL N L +LP + + L + LS N LPE L + L + +++N++
Sbjct: 471 LQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
Query: 184 QTL-PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
++ P + + L LDL N L +PPE+G +L L L N
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 47.0 bits (110), Expect = 8e-05
Identities = 29/92 (31%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSEL-PEALGALPA 172
L +LP + L L ++LSFN + LP + ++ L +L+S+N + + P+ + +
Sbjct: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
LT L + +N L +PP LG L+ L L N
Sbjct: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 105 bits (262), Expect = 2e-22
Identities = 80/217 (36%), Positives = 111/217 (51%), Gaps = 16/217 (7%)
Query: 68 RLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHL 127
RLS H D L A L SL R L AC L +P + L L
Sbjct: 562 RLSLHNDGARLVA-----------LNSLKKLAALRELELVAC---GLERIPHAVFSLGAL 607
Query: 128 AHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
LDL N L ++ + R L L L HN ++ +PE + L +L L +++N+L+T
Sbjct: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667
Query: 186 LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLL 245
LP LG S L+ LD+S N L +LPPE+G L +L L L+ N L++LP L R LR L
Sbjct: 668 LPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTL 727
Query: 246 VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
+L N L+ + + L L+RL+L+ N+L LP EL
Sbjct: 728 LLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEEL 764
Score = 82.0 bits (201), Expect = 2e-15
Identities = 68/211 (32%), Positives = 99/211 (46%), Gaps = 20/211 (9%)
Query: 68 RLSTHEDPQLLEATLAQLPQ---SLSCLRSLVLKGGQRRD-----TLGACLR-------- 111
+L+ + +L+ L ++P SL L+ L LK R + C +
Sbjct: 580 KLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWH 639
Query: 112 GALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
+ +P + L L L LS+N LETLP+ + GL L +SHN L LP +G L
Sbjct: 640 NQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQ 699
Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
L L +++N L+ LP L L+ L L N L L P +G L +L L L NRL++
Sbjct: 700 NLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEA 759
Query: 232 LPASL---AGLRSLRLLVLHSNLLASVPADL 259
LP L GL+ LLV L +PA++
Sbjct: 760 LPEELGNCGGLKKAGLLV-EDTLYQGLPAEV 789
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/220 (28%), Positives = 84/220 (38%), Gaps = 55/220 (25%)
Query: 118 PAGLSGLAHLAHLDL------------------------SFNSLETLPACVLQMRGLGAL 153
P GLS L HL L L L +P V +RGL L
Sbjct: 453 PPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEEL 512
Query: 154 LLSHNCLSELP-----EALGALPALTFLTVTHN-------------RLQTLP-------- 187
L EL E+L L L L++ N LQ L
Sbjct: 513 HLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARL 572
Query: 188 ---PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP--ASLAGLRSL 242
+L L+ L+ L+L L+ +P + LG+L EL+L N L+S+ S R L
Sbjct: 573 VALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKL 632
Query: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L L N +A VP + +L L +L L N+L LP +L
Sbjct: 633 VTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL 672
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 102 bits (254), Expect = 2e-21
Identities = 82/202 (40%), Positives = 101/202 (50%), Gaps = 12/202 (5%)
Query: 78 LEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSL 137
L A A++ +L LR L L Q L LPA L LAHL LD+SFN L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQ------------LPALPAQLGALAHLEELDVSFNRL 170
Query: 138 ETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQ 197
LP + + L L + HN L+ P L L AL L V+ NRL+ LP + AL L+
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALK 230
Query: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
L LS L TLP L SL L L +N LQ+LPA + L+ L++L L SNL PA
Sbjct: 231 ILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPA 290
Query: 258 DLARLPLLTRLDLRDNQLRDLP 279
L L L L L NQL +P
Sbjct: 291 ALLPLAGLEELYLSRNQLTSVP 312
Score = 97.8 bits (242), Expect = 4e-20
Identities = 70/185 (37%), Positives = 97/185 (52%), Gaps = 3/185 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
L +LP LS L+ L LD+ N L P +LQ+ L L +S N L LPE + AL AL
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L ++ L TLP L++L+ L L N L LP + L L LNL+SN + P
Sbjct: 230 KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---L 290
A+L L L L L N L SVP+ ++ L L L L +N++R LP +++ + L
Sbjct: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349
Query: 291 QGNPL 295
QGN +
Sbjct: 350 QGNQI 354
Score = 97.4 bits (241), Expect = 5e-20
Identities = 80/239 (33%), Positives = 110/239 (46%), Gaps = 24/239 (10%)
Query: 82 LAQLPQSLSCL------------------RSLVLKGGQRRDTLGACLRGALTNLPAGLSG 123
LA LP SLSCL + L L + D LRG LP +S
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRG----LPEDISA 225
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L L LS L TLPA ++ L +L+L +N L LP L L L ++ N
Sbjct: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
+ P AL L+ L+ L LS+N L ++P I GLG LL L L +NR++ LP S+ L L
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE--LLDAPFVRLQGNPLGEASP 300
LVL N +A +P +L + ++DN L P E + P++ L + P
Sbjct: 346 ELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404
Score = 93.6 bits (231), Expect = 7e-19
Identities = 83/239 (34%), Positives = 110/239 (46%), Gaps = 17/239 (7%)
Query: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQ--RRDTLGACLRGALT 115
P L +E L L + LE L +L LR LVL+ + R A L LT
Sbjct: 59 PANLGDIEALNLGNNG----LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114
Query: 116 NLPAG-----------LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELP 164
L +S L L L+LS N L LPA + + L L +S N L+ LP
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 174
Query: 165 EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNL 224
++L L L L V HN+L P L L L+ LD+S N L LP +I L +L L L
Sbjct: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
Query: 225 ASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELL 283
+ L +LPA L SL L+L +N L ++PA + L L L+L N + P LL
Sbjct: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
Score = 72.4 bits (176), Expect = 2e-12
Identities = 69/224 (30%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 56 QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLK--GGQRRDTL--GACLR 111
+Q LQL+ +E L +S++ L LP+ +S LR+L + G TL G C
Sbjct: 198 RQLLQLVALEELDVSSNR--------LRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249
Query: 112 GALTNL----------PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLS 161
+L +L PA S L L L+LS N E PA +L + GL L LS N L+
Sbjct: 250 ASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLT 309
Query: 162 ELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE 221
+P + L L L + +NR++ LP ++ L+ L+ L L N + LP G L +
Sbjct: 310 SVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGL 369
Query: 222 LNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
+ N L P + + L S PA RL LL
Sbjct: 370 WKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLL 413
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 100 bits (248), Expect = 8e-21
Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)
Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
+R L +P + L +L +DL N+L+T+ + + L L L +N ++ +P +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658
Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
G L L L + N+++ +P L L+ LDLS N L LP +IG L +L L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718
Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
R+++LP L R LR L L +N+L S+P+ + L LT+++LR N+L LP EL + P
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
Query: 288 VRLQG 292
++ G
Sbjct: 779 LKRSG 783
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L L L +N + +P + + L L L+ N + ++P L L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
LP +G L LQ L ++ N ++TLPPE+ L L+L +N LQSLP+ + L +L
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
+ L N L +P +L PLL R L + ++ LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 70.5 bits (171), Expect = 7e-12
Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT LPA + L +L +L ++ N +ETLP + Q R L AL L +N L LP +G L L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
T + + NRL+ LP LG L+R L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 37.7 bits (86), Expect = 0.048
Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
+L LR + K Q + L + L+ +P + L L L L T+P + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468
Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
GL L L H AL L L L + ++ +P + +L TL+ L L+ NL
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528
Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
+ I GL L L + + L LP + + +L+VL+S
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588
Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
NL L + DL R+P L +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 100 bits (248), Expect = 8e-21
Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)
Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
+R L +P + L +L +DL N+L+T+ + + L L L +N ++ +P +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658
Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
G L L L + N+++ +P L L+ LDLS N L LP +IG L +L L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718
Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
R+++LP L R LR L L +N+L S+P+ + L LT+++LR N+L LP EL + P
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
Query: 288 VRLQG 292
++ G
Sbjct: 779 LKRSG 783
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L L L +N + +P + + L L L+ N + ++P L L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
LP +G L LQ L ++ N ++TLPPE+ L L+L +N LQSLP+ + L +L
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
+ L N L +P +L PLL R L + ++ LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 70.5 bits (171), Expect = 7e-12
Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT LPA + L +L +L ++ N +ETLP + Q R L AL L +N L LP +G L L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
T + + NRL+ LP LG L+R L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 37.7 bits (86), Expect = 0.048
Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
+L LR + K Q + L + L+ +P + L L L L T+P + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468
Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
GL L L H AL L L L + ++ +P + +L TL+ L L+ NL
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528
Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
+ I GL L L + + L LP + + +L+VL+S
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588
Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
NL L + DL R+P L +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 100 bits (248), Expect = 8e-21
Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)
Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
+R L +P + L +L +DL N+L+T+ + + L L L +N ++ +P +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658
Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
G L L L + N+++ +P L L+ LDLS N L LP +IG L +L L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718
Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
R+++LP L R LR L L +N+L S+P+ + L LT+++LR N+L LP EL + P
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
Query: 288 VRLQG 292
++ G
Sbjct: 779 LKRSG 783
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L L L +N + +P + + L L L+ N + ++P L L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
LP +G L LQ L ++ N ++TLPPE+ L L+L +N LQSLP+ + L +L
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
+ L N L +P +L PLL R L + ++ LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 70.5 bits (171), Expect = 7e-12
Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT LPA + L +L +L ++ N +ETLP + Q R L AL L +N L LP +G L L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
T + + NRL+ LP LG L+R L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 37.7 bits (86), Expect = 0.048
Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
+L LR + K Q + L + L+ +P + L L L L T+P + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468
Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
GL L L H AL L L L + ++ +P + +L TL+ L L+ NL
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528
Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
+ I GL L L + + L LP + + +L+VL+S
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588
Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
NL L + DL R+P L +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 99.4 bits (246), Expect = 1e-20
Identities = 64/199 (32%), Positives = 107/199 (53%), Gaps = 2/199 (1%)
Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
LP + L + L+L N L++LP V ++ L L ++ NCL+E+P L L L
Sbjct: 86 LPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVL 145
Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
+++HN L LP LS L++L+LS N +P + L L+ L++ SNRL+++ S+
Sbjct: 146 SLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESI 205
Query: 237 AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL-LDAPFVRLQGNPL 295
L SL++ + N + S P L + L L+L +N ++ LP EL L VR+ NP+
Sbjct: 206 QHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNPM 265
Query: 296 GEASPDAPSSPVAALIPEM 314
+ +P++ +PE+
Sbjct: 266 -DKGLHISHNPLSKPLPEL 283
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 99.0 bits (245), Expect = 2e-20
Identities = 70/187 (37%), Positives = 98/187 (52%), Gaps = 7/187 (3%)
Query: 114 LTNLPAGLSG--LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
L P G + L DLS N L +P L L L NC+ +PEA+ L
Sbjct: 69 LREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQ 128
Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
ALTFL ++ N+L TLP L L L+ L S N L +LP EIG L L+EL+++ N +Q+
Sbjct: 129 ALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQT 187
Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFV 288
+P+ + L +LR L + N L +P +LA LPL+ RLD N++ +P L +
Sbjct: 188 IPSQIGNLEALRDLNVRRNHLVHLPEELAELPLI-RLDFSCNKITTIPVCYRNLRHLQTI 246
Query: 289 RLQGNPL 295
L NPL
Sbjct: 247 TLDNNPL 253
Score = 85.9 bits (211), Expect = 2e-16
Identities = 62/180 (34%), Positives = 93/180 (51%), Gaps = 3/180 (1%)
Query: 104 DTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE 162
DT A L R L+ +P L +L+L N + +P +L ++ L L +S N LS
Sbjct: 83 DTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLST 142
Query: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
LP L LP L L ++N+L +LP +G L L LD+S N + T+P +IG L +L +L
Sbjct: 143 LPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDL 201
Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
N+ N L LP LA L +R L N + ++P L L + L +N L+ P ++
Sbjct: 202 NVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 96.7 bits (239), Expect = 9e-20
Identities = 60/181 (33%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
L +P + L L LDL N+L+++ V +R L L L HN ++ +PE + L
Sbjct: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
+L L+ +HN+++ LP L + ++ LDLS N + +PPEIG L SL ++ N+++S
Sbjct: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
LP L + L+ L + N L+ + + L L+ LD++ N LPPEL D ++
Sbjct: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780
Query: 292 G 292
G
Sbjct: 781 G 781
Score = 76.6 bits (187), Expect = 9e-14
Identities = 49/174 (28%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
+L + +V R+ T+ ++T +P + L L L S N +E LP+ +
Sbjct: 623 NLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLC 682
Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
+ L LS+N + +P +G L +L + ++T N++++LP L L+ L + +N L
Sbjct: 683 NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLS 742
Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL--LVLHSNLLASVPADL 259
L P+IG L L L++ N + LP L R+L+ LV+ L ++P+D+
Sbjct: 743 VLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
Score = 32.3 bits (72), Expect = 2.0
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
RL+L +L LP + + L L L + +PA++A L +L+ L LH SV
Sbjct: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481
Query: 258 DLARLPLLTR----LDLRDNQLRDLPP 280
A L L L ++ + +R+LPP
Sbjct: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 95.9 bits (237), Expect = 1e-19
Identities = 60/165 (36%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
Query: 120 GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVT 179
GL L+H+ L LS N L +P + +++ L L +N + ELP + +L L L +
Sbjct: 35 GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94
Query: 180 HNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
NRL TLP G+L L+ LDL+ N L ++LP L +L L L+ N + LP +
Sbjct: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 154
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L L++L L N L S+P ++ L L L ++ N+L LPPEL
Sbjct: 155 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
Score = 87.0 bits (214), Expect = 7e-17
Identities = 58/153 (37%), Positives = 82/153 (53%), Gaps = 2/153 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
LT +P ++ L +L L+ N +E LP + ++ L L L N L+ LP G+LPAL
Sbjct: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
Query: 174 TFLTVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
L +T+N L +LP L+TL+ L LS N + LPP+IG L L L+L N L S
Sbjct: 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171
Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPL 264
LP + L L+ L + N L +P +L L L
Sbjct: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 95.5 bits (236), Expect = 2e-19
Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)
Query: 41 DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
+LY GC +QL + ++ Q L+ L+ +L+ S PQ++ L L Q LS
Sbjct: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572
Query: 92 LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
+ +VL ++ L + + L +P + L +L LDL N+L+T+ + +
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
+ L L L HN ++ +P +GAL L L++ HN ++ LP L + L LDLS N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
+P EI L +L + +N ++ LP L + L+ L+L N L ++ + L LT
Sbjct: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752
Query: 268 LDLRDNQLRDLPPEL 282
L+L N L LPPEL
Sbjct: 753 LELIGNYLETLPPEL 767
Score = 85.9 bits (211), Expect = 2e-16
Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)
Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
+PA + L++L L L N++E LP + L L LS+N L+ +PE + L L +
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
VT+N ++ LP L LQ L L +N L L P +G L +L L L N L++LP L
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
Query: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
G +SL+ L++ NLL ++P LP+ RL
Sbjct: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ NLP L L +LDLS+N L +P + + L +++N + LP+ L L
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
L + N L L P +G LS L L+L N L+TLPPE+ G SL L + N L +
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787
Query: 232 LP 233
LP
Sbjct: 788 LP 789
Score = 35.0 bits (79), Expect = 0.31
Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)
Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
++L L LP V ++ + L L +LP A+ L L L V H+ L PA
Sbjct: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481
Query: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
L L L+ L L + +P + L +L EL L+ L Q L G L++LR
Sbjct: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541
Query: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
L L S+L + V DL LP L +L L DN+
Sbjct: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 95.5 bits (236), Expect = 2e-19
Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)
Query: 41 DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
+LY GC +QL + ++ Q L+ L+ +L+ S PQ++ L L Q LS
Sbjct: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572
Query: 92 LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
+ +VL ++ L + + L +P + L +L LDL N+L+T+ + +
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
+ L L L HN ++ +P +GAL L L++ HN ++ LP L + L LDLS N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
+P EI L +L + +N ++ LP L + L+ L+L N L ++ + L LT
Sbjct: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752
Query: 268 LDLRDNQLRDLPPEL 282
L+L N L LPPEL
Sbjct: 753 LELIGNYLETLPPEL 767
Score = 85.9 bits (211), Expect = 2e-16
Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)
Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
+PA + L++L L L N++E LP + L L LS+N L+ +PE + L L +
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
VT+N ++ LP L LQ L L +N L L P +G L +L L L N L++LP L
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
Query: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
G +SL+ L++ NLL ++P LP+ RL
Sbjct: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ NLP L L +LDLS+N L +P + + L +++N + LP+ L L
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
L + N L L P +G LS L L+L N L+TLPPE+ G SL L + N L +
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787
Query: 232 LP 233
LP
Sbjct: 788 LP 789
Score = 35.0 bits (79), Expect = 0.31
Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)
Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
++L L LP V ++ + L L +LP A+ L L L V H+ L PA
Sbjct: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481
Query: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
L L L+ L L + +P + L +L EL L+ L Q L G L++LR
Sbjct: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541
Query: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
L L S+L + V DL LP L +L L DN+
Sbjct: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 95.5 bits (236), Expect = 2e-19
Identities = 62/161 (38%), Positives = 90/161 (55%), Gaps = 1/161 (0%)
Query: 123 GLAHLAHLDLSFNSLETLPACVLQ-MRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
GL +L L + NSL +LP + Q + L L L N + +PEA+G+L L L ++ N
Sbjct: 39 GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
L+ + P +G L L+ L L+ N L LPPE+G L L L++++NRL +LP L S
Sbjct: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L+ L + N L VP L +LP L L + N+L LP +L
Sbjct: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/174 (37%), Positives = 91/174 (52%), Gaps = 2/174 (1%)
Query: 111 RGALTNLPAGLSG-LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
R +LT+LP L+ L +L L L N++ +P + + L L LS N L + +G
Sbjct: 50 RNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGR 109
Query: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
L AL L + +N+LQ LPP +G L LQ LD+S N L TLP + SL L + NRL
Sbjct: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169
Query: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
+P L L SL L + N LA +P DL R L + + +N L+ LP L
Sbjct: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
Score = 83.2 bits (204), Expect = 1e-15
Identities = 59/162 (36%), Positives = 87/162 (53%), Gaps = 4/162 (2%)
Query: 129 HLDLSFNSLETLPACVLQMRGLG---ALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQ 184
+L L++ +L P +L+ GL L + N L+ LPE L LP L L + N +
Sbjct: 19 NLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78
Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
+P A+G+L LQ LDLS N L+ + PEIG L +L L LA+N+LQ LP + L+ L+
Sbjct: 79 VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138
Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
L + +N L ++P L L L + N+L +P L P
Sbjct: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 94.4 bits (233), Expect = 4e-19
Identities = 58/166 (34%), Positives = 88/166 (53%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+ N P+ L L +L L L N L +P + ++ L L L +N L+ P+AL LP L
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L +T N + +LP + L L+ L + N L L EI L + EL LA N+L+ +
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
+ R LR+L+L NLL ++P ++ +L L L DN+L +LP
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
Score = 87.8 bits (216), Expect = 4e-17
Identities = 54/170 (31%), Positives = 86/170 (50%), Gaps = 1/170 (0%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL-QMRGLGALLLSHNCLSELPEALGALPA 172
L P + + ++ +L L N ++T + GL L L N LS LP + L
Sbjct: 153 LQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHN 212
Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
L L V+HN + +P + L +++L N ++ P ++ LG+L L+L N+L+ +
Sbjct: 213 LRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272
Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
P +L L++LR+L L N L + P L LP L LDL N + LP E+
Sbjct: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI 322
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/182 (29%), Positives = 92/182 (50%), Gaps = 4/182 (2%)
Query: 98 KGGQRRDTLG----ACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGAL 153
+G D LG + L++LP+ + L +L L++S N + +P + Q+ + L
Sbjct: 180 QGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL 239
Query: 154 LLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
+N + P L L L L++ N+L+ +P L +L TL+ L+L N L T P +
Sbjct: 240 FFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299
Query: 214 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN 273
L L+ L+L N + SLP + L++L L++ N L + ++ +L + L L DN
Sbjct: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADN 359
Query: 274 QL 275
+L
Sbjct: 360 KL 361
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/169 (29%), Positives = 84/169 (49%), Gaps = 3/169 (1%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
++ +P +S L HL+LS N L + L L L N + ++P ++ + +L
Sbjct: 499 ISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISL 558
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L + N+ +T P L L LQ LDLS+N L + +I L + +LN +SN+ P
Sbjct: 559 HVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFP 618
Query: 234 ASLAGLRSLRLL---VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
L L+SL L + L +P +L+ + L LD+ +N +R++P
Sbjct: 619 IELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIP 667
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 14/215 (6%)
Query: 82 LAQLPQSLSCLRSL-VLKGGQRR-----DTLGAC--LR------GALTNLPAGLSGLAHL 127
+ P L CL +L +L G+ + DTL + LR LT P L L L
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305
Query: 128 AHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLP 187
LDL+ N + +LP + +++ L LL+ HN L+ L + L + L + N+L+ +
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
Query: 188 PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVL 247
+ L+ L L +NLL +P +I L L+L+ N+L LP + L +LR L +
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 248 HSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
+ N + + ++ L + L+ N + D+P E+
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEI 460
Score = 74.3 bits (181), Expect = 5e-13
Identities = 48/172 (27%), Positives = 88/172 (51%)
Query: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
R + + +S L ++ L+ S N + +P + + + + LS+N + P L AL
Sbjct: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486
Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
+L +L+V N + +P + L L+LS+N L L +L L+L N+++
Sbjct: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546
Query: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
+PAS++ + SL +L+L N + P +L L L LDL +NQL+ + ++
Sbjct: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Score = 74.3 bits (181), Expect = 5e-13
Identities = 53/191 (27%), Positives = 92/191 (48%), Gaps = 6/191 (3%)
Query: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
+ + +PA +S + L L L N ET P + + L L LS N L ++ + L
Sbjct: 542 KNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNL 601
Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQ---NLLDTLPPEIGGLGSLLELNLASN 227
+ L + N+ P L L +L++L++SQ L LP E+ + L EL++++N
Sbjct: 602 KGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNN 661
Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLD 284
++ +P ++ LR+L L ++N ++ +P L L L +L+L N L LP +
Sbjct: 662 AIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS 721
Query: 285 APFVRLQGNPL 295
+ NPL
Sbjct: 722 LKEINFDDNPL 732
Score = 73.6 bits (179), Expect = 8e-13
Identities = 51/159 (32%), Positives = 80/159 (50%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L L L L N L +LP+ + + L L +SHN +S +P+ + L + L +N +
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
+ P L L L+ L L +N L +P + L +L LNL N+L + P +L L L
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L L NL++S+P ++ L L L + N+L L E+
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEI 345
Score = 73.6 bits (179), Expect = 8e-13
Identities = 45/169 (26%), Positives = 82/169 (48%)
Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
+T++P + + ++LS+N + P + + L L ++ N +SE+P + L
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQL 512
Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
L ++ N+L +L L+ LDL +N + +P I + SL L L N+ ++ P
Sbjct: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP 572
Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
L L +L++L L N L + +D+ L + +L+ NQ P EL
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIEL 621
Score = 71.2 bits (173), Expect = 4e-12
Identities = 66/274 (24%), Positives = 122/274 (44%), Gaps = 46/274 (16%)
Query: 39 SLDLYPGGCQQLLHLCVQQP----LQLLQVEFLRLSTHED-----PQLLEATL-----AQ 84
+L++ G +L H+ P L++L +E+ +L+T P+L+ L +
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
Query: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
LP+ + L++L +TL LT L + L + L L+ N LE + +
Sbjct: 318 LPKEIRELKNL--------ETL-LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
Query: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR------ 198
R L L+L N L +PE + L L+++ N+L LP + L+ L++
Sbjct: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Query: 199 -----------------LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
L+ S N++ +P EI ++++ L+ N++ P L L S
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
L L ++ N ++ +P D++ L L+L +N+L
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKL 522
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 1/158 (0%)
Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEA-LGALPALTFLTVTHNRLQTLPP 188
++L L+ P +L+++ + L L N + A G L L L++ N L +LP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
+ L L+ L++S N + +P EI LG++ +L +N +++ P+ L L +L +L L
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
N L +P L L L L+L NQL P L P
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Score = 67.0 bits (162), Expect = 7e-11
Identities = 48/168 (28%), Positives = 85/168 (50%), Gaps = 3/168 (1%)
Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
P GL L L +L ++ N + +P + + L L LS N L E +L L +L
Sbjct: 480 PLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLD 539
Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
+ N+++ +P ++ + +L L L N +T P E+ L +L L+L+ N+LQ + + +
Sbjct: 540 LGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC 599
Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLD---LRDNQLRDLPPEL 282
L+ ++ L SN P +L +L L +L+ ++ +L LP EL
Sbjct: 600 NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647
Score = 65.1 bits (157), Expect = 3e-10
Identities = 67/262 (25%), Positives = 111/262 (42%), Gaps = 43/262 (16%)
Query: 48 QQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTL 106
+QLLHL + + L + F L + L + + ++P S+S + SL L
Sbjct: 510 KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISL--------HVL 561
Query: 107 GACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHN-------- 158
C T P L L +L LDLS N L+ + + + ++G+ L S N
Sbjct: 562 ILCCNKFET-FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620
Query: 159 -C-----------------LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLD 200
C L+ LP L + L L +++N ++ +P +G L L L
Sbjct: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680
Query: 201 LSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
N + LPP + L L +LNL+ N L +LP+++ + SL+ + N L P ++
Sbjct: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740
Query: 261 R-------LPLLTRLDLRDNQL 275
+ L R D RD ++
Sbjct: 741 KGKQLYTIARYLQRADERDEKI 762
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 92.8 bits (229), Expect = 1e-18
Identities = 63/175 (36%), Positives = 94/175 (53%), Gaps = 5/175 (2%)
Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
L+ DLS N L +P + L L L HNC+ +PEA+ L LT+L ++ N+L
Sbjct: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
LP L L L+ L S N L +LP EIG L L+EL+++ N + +LP + L+SLR
Sbjct: 156 SALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLR 214
Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
L + N L +P +L LPL+ + D N++ +P E+ + L+ NPL
Sbjct: 215 ELNVRRNYLKVLPQELVDLPLV-KFDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
Score = 63.9 bits (154), Expect = 6e-10
Identities = 47/142 (33%), Positives = 67/142 (47%), Gaps = 23/142 (16%)
Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
+P + L L +L+LS N L LPAC+ + L L+ S+N L LPE +G L L L
Sbjct: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMEL 193
Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------------------- 217
V+ N + LP +G L +L+ L++ +N L LP E+ L
Sbjct: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFR 253
Query: 218 ---SLLELNLASNRLQSLPASL 236
L L L +N LQS PA +
Sbjct: 254 EMKQLQVLLLENNPLQSPPAQI 275
Score = 47.4 bits (111), Expect = 6e-05
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 23/168 (13%)
Query: 50 LLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
L H C+ + + L + +L LS ++ L+ LP +CL L LK
Sbjct: 127 LYHNCIRVIPEAIVNLQMLTYLNLSRNQ--------LSALP---ACLCGLPLK------- 168
Query: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
+ L +LP + L L LD+S N + LP + Q++ L L + N L LP+
Sbjct: 169 VLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQ 228
Query: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
L LP + F + N++ +P + LQ L L N L + P +I
Sbjct: 229 ELVDLPLVKF-DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 92.0 bits (227), Expect = 2e-18
Identities = 148/607 (24%), Positives = 250/607 (41%), Gaps = 76/607 (12%)
Query: 300 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 357
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 932 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 991
Query: 358 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 414
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 992 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1051
Query: 415 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 455
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1052 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1111
Query: 456 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 515
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1112 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1170
Query: 516 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 567
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1171 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1229
Query: 568 TAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 624
T L + A F + +WL + A ++ L + + +
Sbjct: 1230 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1289
Query: 625 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 682
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1290 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1347
Query: 683 PDCVEGRICFVFYSHLKNVKEVSFYRGAVPVRVPEEAEAARQRKGADALW---------- 732
+ F F S +N R A+PV+V +++R+ G+ +
Sbjct: 1348 ---AAQQRSFHFQSFREN-------RLAMPVKV---RDSSREPGGSLSFLRKAMKYEDTQ 1394
Query: 733 --MATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLLSVAGR 781
+ L I +P + G+E RR L+L L ++ G L+ + + ++
Sbjct: 1395 HILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEH 1454
Query: 782 LGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALE 841
LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L AL+
Sbjct: 1455 LGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENLYTALQ 1513
Query: 842 QSDRQDV 848
DR ++
Sbjct: 1514 SIDRGEI 1520
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 92.0 bits (227), Expect = 2e-18
Identities = 148/607 (24%), Positives = 250/607 (41%), Gaps = 76/607 (12%)
Query: 300 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 357
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 891 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 950
Query: 358 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 414
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 951 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1010
Query: 415 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 455
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1011 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1070
Query: 456 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 515
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1071 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1129
Query: 516 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 567
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1130 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1188
Query: 568 TAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 624
T L + A F + +WL + A ++ L + + +
Sbjct: 1189 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1248
Query: 625 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 682
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1249 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1306
Query: 683 PDCVEGRICFVFYSHLKNVKEVSFYRGAVPVRVPEEAEAARQRKGADALW---------- 732
+ F F S +N R A+PV+V +++R+ G+ +
Sbjct: 1307 ---AAQQRSFHFQSFREN-------RLAMPVKV---RDSSREPGGSLSFLRKAMKYEDTQ 1353
Query: 733 --MATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLLSVAGR 781
+ L I +P + G+E RR L+L L ++ G L+ + + ++
Sbjct: 1354 HILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEH 1413
Query: 782 LGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALE 841
LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L AL+
Sbjct: 1414 LGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENLYTALQ 1472
Query: 842 QSDRQDV 848
DR ++
Sbjct: 1473 SIDRGEI 1479
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,455,956
Number of Sequences: 37866
Number of extensions: 1946091
Number of successful extensions: 8051
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 6169
Number of HSP's gapped (non-prelim): 1011
length of query: 893
length of database: 18,247,518
effective HSP length: 111
effective length of query: 782
effective length of database: 14,044,392
effective search space: 10982714544
effective search space used: 10982714544
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.