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Search of human proteins with 13540563
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13540563 complement factor H-related 5 [Homo sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13540563 complement factor H-related 5 [Homo sapiens] 1230 0.0
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 479 e-135
gi|118442839 complement factor H-related 1 [Homo sapiens] 331 1e-90
gi|239758113 PREDICTED: similar to complement factor H-related 1... 331 1e-90
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 274 2e-73
gi|239758115 PREDICTED: similar to complement factor H-related 1... 271 1e-72
gi|5031695 H factor (complement)-like 3 [Homo sapiens] 267 2e-71
gi|117320518 complement factor H-related 4 [Homo sapiens] 200 3e-51
gi|54792787 complement factor H-related 3 [Homo sapiens] 194 2e-49
gi|148886654 polydom [Homo sapiens] 127 3e-29
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 123 5e-28
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 123 5e-28
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 122 9e-28
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 114 3e-25
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 114 3e-25
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 114 3e-25
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 113 4e-25
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 112 7e-25
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 106 7e-23
gi|4502503 complement component 4 binding protein, alpha chain p... 97 3e-20
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 93 6e-19
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 90 6e-18
gi|187960042 selectin E precursor [Homo sapiens] 88 2e-17
gi|157419154 selectin P precursor [Homo sapiens] 87 3e-17
gi|153266841 apolipoprotein H precursor [Homo sapiens] 72 1e-12
gi|148539593 sushi domain containing 4 isoform a [Homo sapiens] 72 2e-12
gi|81295416 sushi domain containing 4 isoform b [Homo sapiens] 69 1e-11
gi|62912468 complement component 4 binding protein, beta chain i... 63 6e-10
gi|62912466 complement component 4 binding protein, beta chain i... 63 6e-10
gi|62912464 complement component 4 binding protein, beta chain i... 63 6e-10
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 1230 bits (3183), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
Query: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI 180
QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI
Sbjct: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI 180
Query: 181 RVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN 240
RVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN
Sbjct: 181 RVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN 240
Query: 241 FIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE 300
FIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE
Sbjct: 241 FIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE 300
Query: 301 YAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCS 360
YAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCS
Sbjct: 301 YAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCS 360
Query: 361 DIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKEN 420
DIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKEN
Sbjct: 361 DIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKEN 420
Query: 421 YLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
YLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS
Sbjct: 421 YLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
Query: 481 FYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQ 540
FYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQ
Sbjct: 481 FYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQ 540
Query: 541 CKFPHKAMISSPPFRAICQEGKFEYPICE 569
CKFPHKAMISSPPFRAICQEGKFEYPICE
Sbjct: 541 CKFPHKAMISSPPFRAICQEGKFEYPICE 569
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 479 bits (1234), Expect = e-135
Identities = 225/455 (49%), Positives = 295/455 (64%), Gaps = 7/455 (1%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQI 112
Y C+ +V+ ITC ++GWS P C++ C P N +++ DT+
Sbjct: 475 YQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDY 534
Query: 113 ICNTGYSLQNNEK--NISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDV 170
C+ GY +I C GWS PIC + EC +P ++ ++ KK+ YKVG+V
Sbjct: 535 ECHDGYESNTGSTTGSIVCGYNGWSDLPICY--ERECELPKIDVHLVPDRKKDQYKVGEV 592
Query: 171 LKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHN 230
LKFSC+ VG +SVQCY FG SP+ P CK QV+SCGPPP+L NG VKE KEEYGH+
Sbjct: 593 LKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHS 652
Query: 231 EVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHG 290
EVVEY CNP F++ GP KIQCVDGEWTTLP C+ + TCG IPELE+G+ Q S PPY +G
Sbjct: 653 EVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYG 712
Query: 291 VSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN 350
SVE NC + MIG+ ITCI+G+WT+LP CVA +LK+CK + + I + KEF+
Sbjct: 713 DSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFD 772
Query: 351 HNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDG 410
HNS IRYRC + H+VCING+W+PEV+C+ + Q CPPPPQIPN+ NMTTT+NY+DG
Sbjct: 773 HNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDG 832
Query: 411 EKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS--VY 468
EKV+VLC+ENYL+ E +EI CKDGRWQS+P CVE C PP I +G S S Y
Sbjct: 833 EKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIP-CSQPPQIEHGTINSSRSSQESY 891
Query: 469 PPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRC 503
G+ ++Y C+ +++ TC +WS PP+C
Sbjct: 892 AHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQC 926
Score = 286 bits (731), Expect = 5e-77
Identities = 170/588 (28%), Positives = 270/588 (45%), Gaps = 80/588 (13%)
Query: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL---RMCS-FPFVKNGHSESSGLIH 104
EV Y C F+ + +I C + W+ P C+ C P +++G ++ S +
Sbjct: 653 EVVEYYCNPRFLMKGPN---KIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPY 709
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKG--ECHVPILEANVDAQPKK 162
GD+V+ C+ +++ + ++I+C+ W+ P C +C L + K
Sbjct: 710 YYGDSVEFNCSESFTMIGH-RSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNK 768
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEI 222
+ + +++ CR + G C W P Q++ C PPPQ+ N
Sbjct: 769 KEFDHNSNIRYRCRG---KEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSH-NMT 824
Query: 223 RKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYV-- 280
Y E V C N++I ++I C DG W ++P CVE++ C P++E+G +
Sbjct: 825 TTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIP-CSQPPQIEHGTINS 883
Query: 281 -QPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMC--------------VAT 325
+ S Y HG + C + + N TC G W+ P C V
Sbjct: 884 SRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVA 943
Query: 326 HQLKRCKIA-----------GVNIKTLLKLSGKEFNH----------------------- 351
H + G++ + K G++++H
Sbjct: 944 HMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGE 1003
Query: 352 -------NSRIRYRCSDIFRY---RHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNM 401
++ Y C+ ++ + CIN +W C R+ C PP + NA +
Sbjct: 1004 KKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC---RDTSCVNPPTVQNAYIV 1060
Query: 402 TTTVN-YQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDT 460
+ ++ Y GE+V C+ Y + +E++C +G W P+C +ST CGPPP I+NGD
Sbjct: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDI 1120
Query: 461 TSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQ 520
TSFPLSVY P S+V Y+CQ+ Y+L+G+ +TCRN QWSEPP+CL PCV+S E M NI
Sbjct: 1121 TSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIA 1180
Query: 521 LKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPIC 568
L+W KLY++TG++VEF CK ++ S R C +GK EYP C
Sbjct: 1181 LRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 1228
Score = 202 bits (515), Expect = 5e-52
Identities = 141/568 (24%), Positives = 258/568 (45%), Gaps = 50/568 (8%)
Query: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
CD+P I HG LY E P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
Query: 83 CLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSF 142
CLR C FP+++NG++++ G ++G ++ + C+ GY+L + ++C+E GWS P C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
Query: 143 TKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVG---SDSVQCYQFGWSPNFP 199
K I N + +Y + + K+ C+ + S S+ C + GWS P
Sbjct: 445 VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQ-P 503
Query: 200 TCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPK---KIQCVDGEW 256
TC ++SC P ++ + + N+ ++Y+C+ + N I C W
Sbjct: 504 TC---IKSCDIPVFMNARTKNDF--TWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGW 558
Query: 257 TTLPTCVEQVKTCGYIPELEYGYV-QPSVPPYQHGVSVEVNCRNEYAMIGNNMITCIN-G 314
+ LP C E + C +P+++ V Y+ G ++ +C+ + ++G N + C + G
Sbjct: 559 SDLPICYE--REC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG 615
Query: 315 IWTELPMCVATHQLKRC----KIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---H 367
+ +LP+C Q++ C ++ N+K K +E+ H+ + Y C+ F +
Sbjct: 616 LSPDLPIC--KEQVQSCGPPPELLNGNVKEKTK---EEYGHSEVVEYYCNPRFLMKGPNK 670
Query: 368 SVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK 427
C++G+W C + E C P++ + ++ Y G+ V C E++ + +
Sbjct: 671 IQCVDGEWTTLPVCIVE-ESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHR 729
Query: 428 EIVCKDGRWQSLPRCV--ESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQ 485
I C G W LP+CV + C I + + S + YRC+ +
Sbjct: 730 SITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLK-NKKEFDHNSNIRYRCRG---KE 785
Query: 486 GSVTVTCRNKQWSEPPRC----LDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQC 541
G + C N +W C + C + N +N+ L + G+ V C
Sbjct: 786 GWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTT------TLNYRDGEKVSVLC 839
Query: 542 KFPHKAMISSPPFRAICQEGKFE-YPIC 568
+ + + C++G+++ P+C
Sbjct: 840 Q---ENYLIQEGEEITCKDGRWQSIPLC 864
Score = 140 bits (354), Expect = 2e-33
Identities = 125/571 (21%), Positives = 213/571 (37%), Gaps = 108/571 (18%)
Query: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RMCSFPFVKNGHSESSGLIHLEG 107
E F Y C + + CTE GW P P C + C P++ NG + H G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
Query: 108 DTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVP-ILEANVDAQPKKESY- 165
D + C G+ C GW P C T C P I + + + Y
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCDYPDIKHGGLYHENMRRPYF 345
Query: 166 --KVGDVLKFSCRKNLIRVGS---DSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVK 220
VG + C ++ D + C Q GWSP P +R C P L NG
Sbjct: 346 PVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC----LRKC-YFPYLENG-YN 399
Query: 221 EIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTCVEQVKTC---------G 270
+ ++ + ++ C+P + + + C++ W+ P C+ +VKTC G
Sbjct: 400 QNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI-RVKTCSKSSIDIENG 458
Query: 271 YIPELEYGYVQPSVPPYQ--------------------HGVSVEVNC------------- 297
+I E +Y Y YQ G S + C
Sbjct: 459 FISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNAR 518
Query: 298 -RNEYAMIGNN--------------------MITCINGIWTELPMCVATHQLKRCKIAGV 336
+N++ N I C W++LP+C + C++ +
Sbjct: 519 TKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE----RECELPKI 574
Query: 337 NIKTLLKLSGKEFNHNSRIRYRCSDIFRY--RHSV-CINGKWNPEVDCTEKREQFCPPPP 393
++ + ++ +++ C F +SV C + +P++ +++ Q C PPP
Sbjct: 575 DVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPP 634
Query: 394 QIPNAQ-NMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPP 452
++ N T Y E V C +L+ +I C DG W +LP C+ + CG
Sbjct: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDI 694
Query: 453 PSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRC-----LDPC 507
P + +G Y G +V + C + + G ++TC + W++ P+C L C
Sbjct: 695 PELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKC 753
Query: 508 -----VVSEENMNK-----NNIQLKWRNDGK 528
++ EE++ +N +++R GK
Sbjct: 754 KSSNLIILEEHLKNKKEFDHNSNIRYRCRGK 784
Score = 122 bits (305), Expect = 1e-27
Identities = 128/558 (22%), Positives = 189/558 (33%), Gaps = 71/558 (12%)
Query: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGW---SPTPKCL-RMCSFPFVK--NGHSES 99
P G Y C + S + C + W +P KC R C P + +
Sbjct: 43 PEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
Query: 100 SGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP-PICSFTKGECHVPILEAN--- 155
G + G CN GY L C GW+ PIC K C N
Sbjct: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPENGKI 157
Query: 156 -VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQ 213
A Y G ++F C G + + C G WS P C SC P
Sbjct: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI--SCKSPDV 215
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIP 273
++ + + K Y NE +Y CN + + C + W LP+C E+ YIP
Sbjct: 216 INGSPISQ--KIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIP 273
Query: 274 ELEYGYVQPSVPPYQHGVSVEVNCRNE-YAMIGNNMITCINGIWTELPMCVATHQLKRCK 332
+Y P ++ G + CRN Y N C + W P C LK C
Sbjct: 274 NGDY---SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCT----LKPCD 326
Query: 333 IAGVNIKTLLKLSGKEFNHNSR-----------IRYRCSDIFR------YRHSVCINGKW 375
+ G ++ N R Y C + F + H C W
Sbjct: 327 YPDIK-------HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGW 379
Query: 376 NPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK-EIVCKDG 434
+P V C K P + N N + G+ + V C Y LP+A+ + C +
Sbjct: 380 SPAVPCLRKCYF-----PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMEN 434
Query: 435 RWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKL---QGSVTVT 491
W PRC+ I NG + + Y Y+C+ Y + S ++T
Sbjct: 435 GWSPTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSIT 493
Query: 492 CRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISS 551
C WS P C+ C + + W K D ++++C +++ S
Sbjct: 494 CGKDGWSAQPTCIKSCDIPVFMNARTKNDFTW-------FKLNDTLDYECHDGYESNTGS 546
Query: 552 PPFRAIC-QEGKFEYPIC 568
+C G + PIC
Sbjct: 547 TTGSIVCGYNGWSDLPIC 564
Score = 80.9 bits (198), Expect = 3e-15
Identities = 93/379 (24%), Positives = 139/379 (36%), Gaps = 39/379 (10%)
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEI 222
++Y G + CR +G+ + C + W P K Q R CG P G
Sbjct: 40 QTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
Query: 223 RKEEYGHNEVVEYDCNPNFIINGPKKI-QCVDGEWTT-LPTCVEQVKTCGYIPELEYGYV 280
+ + Y CN + + G +C WT +P C +V C + E G +
Sbjct: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC--EVVKCLPVTAPENGKI 157
Query: 281 QPSV----PPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLKRCKIA 334
S Y G +V C + Y + G+ + C +G W+ E P CV I
Sbjct: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVIN 217
Query: 335 GVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH---SVCINGKWNPEVDCTEKREQFCPP 391
G I K+ KE N R +Y+C+ + Y +VC W P C EK C
Sbjct: 218 GSPISQ--KIIYKE---NERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS---C-D 268
Query: 392 PPQIPNAQNMTTTVNYQDGEKVAVLCKEN-YLLPEAKEIVCKDGRWQSLPRCVESTAYCG 450
P IPN + ++ G+++ C+ Y C W PRC + C
Sbjct: 269 NPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCD 326
Query: 451 PPPSINNG------DTTSFPLSVYPPGSTVTYRCQSFYKL-QGSV--TVTCRNKQWSEPP 501
P + G FP++V G +Y C ++ GS + C WS
Sbjct: 327 YPDIKHGGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAV 383
Query: 502 RCLDPCVVS--EENMNKNN 518
CL C E N+N+
Sbjct: 384 PCLRKCYFPYLENGYNQNH 402
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/272 (21%), Positives = 103/272 (37%), Gaps = 34/272 (12%)
Query: 287 YQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCK------IAGVNIKT 340
Y G CR Y +GN ++ C G W VA + L++C+ T
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEW------VALNPLRKCQKRPCGHPGDTPFGT 95
Query: 341 LLKLSGKEFNHNSRIRYRCSDIFR----YRHSVCINGKWNPEVDCTEKREQFCPPPPQIP 396
G F + + Y C++ ++ + C W ++ E + C P
Sbjct: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPE 153
Query: 397 NAQNMTTTV----NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCG 450
N + +++ + Y G+ V +C Y + +E+ C DG W + P+CVE +
Sbjct: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC--- 210
Query: 451 PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVS 510
P + NG S + +Y Y+C Y+ C W P C + +
Sbjct: 211 KSPDVINGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDN 269
Query: 511 EENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK 542
N + L+ ++ +TGD + +QC+
Sbjct: 270 PYIPNGDYSPLRIKH------RTGDEITYQCR 295
Score = 34.7 bits (78), Expect = 0.24
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 449 CGPPPSINNGD--TTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQW 497
C P N + T S+ YP G+ Y+C+ Y+ G+V + CR +W
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 331 bits (848), Expect = 1e-90
Identities = 170/329 (51%), Positives = 200/329 (60%), Gaps = 9/329 (2%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
M LL SVILIS +S+VGGE T CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
SPSKSFWTRITCTEEGWSPTPKCLR+C FPFV+NGHSESSG HLEGDTVQIICNTGY L
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL 179
QNNE NISCVERGWSTPP C T C P N ++ S Y G+ +++ CR
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
Query: 180 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP 239
G + V C W+ P CK CGPPP + NG++ Y VEY C
Sbjct: 181 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 239
Query: 240 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN 296
+ + G K+I C +G+W+ P C+ I E + + + G S E
Sbjct: 240 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 299
Query: 297 CRNEYAMIGNN---MITCINGIWTELPMC 322
C+ Y + + TC +G E P C
Sbjct: 300 CKRGYRLSSRSHTLRTTCWDG-KLEYPTC 327
Score = 199 bits (505), Expect = 7e-51
Identities = 101/265 (38%), Positives = 146/265 (55%), Gaps = 12/265 (4%)
Query: 309 ITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS 368
ITC W+ P C L+ C V + SG+ ++ C+ +R +++
Sbjct: 70 ITCTEEGWSPTPKC-----LRLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNN 123
Query: 369 V----CINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLL 423
C+ W+ C + C PP + NA ++ ++ Y GE+V C+ Y +
Sbjct: 124 ENNISCVERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEM 182
Query: 424 PEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYK 483
+E++C +G W P+C +ST CGPPP I+NGD TSFPLSVY P S+V Y+CQ+ Y+
Sbjct: 183 FGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 242
Query: 484 LQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKF 543
L+G+ +TCRN QWSEPP+CL PCV+S E M NI L+W KLY +TG++ EF CK
Sbjct: 243 LEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKR 302
Query: 544 PHKAMISSPPFRAICQEGKFEYPIC 568
++ S R C +GK EYP C
Sbjct: 303 GYRLSSRSHTLRTTCWDGKLEYPTC 327
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 331 bits (848), Expect = 1e-90
Identities = 170/329 (51%), Positives = 200/329 (60%), Gaps = 9/329 (2%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
M LL SVILIS +S+VGGE T CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
SPSKSFWTRITCTEEGWSPTPKCLR+C FPFV+NGHSESSG HLEGDTVQIICNTGY L
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL 179
QNNE NISCVERGWSTPP C T C P N ++ S Y G+ +++ CR
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180
Query: 180 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP 239
G + V C W+ P CK CGPPP + NG++ Y VEY C
Sbjct: 181 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 239
Query: 240 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN 296
+ + G K+I C +G+W+ P C+ I E + + + G S E
Sbjct: 240 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 299
Query: 297 CRNEYAMIGNN---MITCINGIWTELPMC 322
C+ Y + + TC +G E P C
Sbjct: 300 CKRGYRLSSRSHTLRTTCWDG-KLEYPTC 327
Score = 199 bits (505), Expect = 7e-51
Identities = 101/265 (38%), Positives = 146/265 (55%), Gaps = 12/265 (4%)
Query: 309 ITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS 368
ITC W+ P C L+ C V + SG+ ++ C+ +R +++
Sbjct: 70 ITCTEEGWSPTPKC-----LRLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNN 123
Query: 369 V----CINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLL 423
C+ W+ C + C PP + NA ++ ++ Y GE+V C+ Y +
Sbjct: 124 ENNISCVERGWSTPPKC-RSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEM 182
Query: 424 PEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYK 483
+E++C +G W P+C +ST CGPPP I+NGD TSFPLSVY P S+V Y+CQ+ Y+
Sbjct: 183 FGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 242
Query: 484 LQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKF 543
L+G+ +TCRN QWSEPP+CL PCV+S E M NI L+W KLY +TG++ EF CK
Sbjct: 243 LEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKR 302
Query: 544 PHKAMISSPPFRAICQEGKFEYPIC 568
++ S R C +GK EYP C
Sbjct: 303 GYRLSSRSHTLRTTCWDGKLEYPTC 327
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 274 bits (700), Expect = 2e-73
Identities = 178/572 (31%), Positives = 262/572 (45%), Gaps = 42/572 (7%)
Query: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
C P + +G++ D + E Y C + + + C +GWS P
Sbjct: 91 CTKPDLSNGYISDVKLLYKIQ-----ENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPT 145
Query: 83 CLR---MCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKN--ISCVERGWSTP 137
C + C P + NG+ ++ D VQ C TGY +K + C+ GWS
Sbjct: 146 CRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLT 205
Query: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPN 197
P C TK +C L N P K++Y+ GDV++F C +N GSD +QCY FGW P
Sbjct: 206 PKC--TKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPE 263
Query: 198 FPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWT 257
P C+G+ C PPP N ++ + Y H E+V +C NF I+G +I+C DG+WT
Sbjct: 264 SPVCEGRRNRCPPPPLPINSKI-QTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWT 322
Query: 258 TLPTCVE--QVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGI 315
P C+E + C P +E G Y +G V C++ Y + G+N ITC G
Sbjct: 323 EPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGK 382
Query: 316 WTELPMCVATHQLKRCKIAGVNIKTLLKLSG--KEFNHNSRIRYRCSDIFRYRHSV---C 370
WT P CV ++ CK V + + G + S + YRC++ + R S C
Sbjct: 383 WTLPPECVENNE--NCKHPPVVMNGAVA-DGILASYATGSSVEYRCNEYYLLRGSKISRC 439
Query: 371 INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQD----GEKVAVLCKENY----L 422
GKW+ C E C N N+ Y+ G+ + +CK+ Y L
Sbjct: 440 EQGKWSSPPVCLEP----CTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495
Query: 423 LPEAK-EIVCKDGRWQSLPRCV--ESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQ 479
P ++ + C G + P C ES C PP I +G S + Y GS+V YRC
Sbjct: 496 TPLSELSVQCNRGEVK-YPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCF 554
Query: 480 SFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEF 539
+ L+GS C + W+ PP CL+PC +S M KNN+ LKW D + + G+ +EF
Sbjct: 555 DHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEF 614
Query: 540 QCK---FPHKAMISSPPFRAICQEGKFEYPIC 568
C+ +P + I+ R C G+ +YP C
Sbjct: 615 ICRGDTYPAELYITGSILRMQCDRGQLKYPRC 646
Score = 246 bits (628), Expect = 4e-65
Identities = 156/504 (30%), Positives = 235/504 (46%), Gaps = 35/504 (6%)
Query: 87 CSFPFVKNG------HSESSGLIHLEGDT-VQIICNTGYSLQNN--EKNISCVERGWSTP 137
C FP V+NG ++ S + D + C GY+ ++ E+ +C GWS
Sbjct: 25 CGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE 84
Query: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGS---DSVQCYQFGW 194
P C F K C P L +N K YK+ + +++ C G + VQC GW
Sbjct: 85 PRC-FKK--CTKPDL-SNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGW 140
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKK---IQC 251
S PTC+ + +C P+L NG +K + + V+Y+C + G KK ++C
Sbjct: 141 SSQ-PTCRKEHETC-LAPELYNGNYSTTQKT-FKVKDKVQYECATGYYTAGGKKTEEVEC 197
Query: 252 VDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC 311
+ W+ P C + C + +E GY P Y+ G V+ C Y + G+++I C
Sbjct: 198 LTYGWSLTPKCTKL--KCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQC 255
Query: 312 IN-GIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSV- 369
N G + E P+C RC + I + ++ + H + C F S
Sbjct: 256 YNFGWYPESPVCEGRRN--RCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAE 313
Query: 370 --CINGKWNPEVDCTEKREQF-CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA 426
C +GKW C E +E+ C PP I N + Y +G+KV CK YLL +
Sbjct: 314 IRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGS 373
Query: 427 KEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG 486
EI C G+W P CVE+ C PP + NG L+ Y GS+V YRC +Y L+G
Sbjct: 374 NEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRG 433
Query: 487 SVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHK 546
S C +WS PP CL+PC V+ + MN+NNI++KW+ +GK+ GD ++F CK +
Sbjct: 434 SKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVL--HGDLIDFVCKQGYD 491
Query: 547 AMISSP--PFRAICQEGKFEYPIC 568
+P C G+ +YP+C
Sbjct: 492 LSPLTPLSELSVQCNRGEVKYPLC 515
>gi|239758115 PREDICTED: similar to complement factor H-related 1
isoform 2 [Homo sapiens]
Length = 271
Score = 271 bits (693), Expect = 1e-72
Identities = 134/198 (67%), Positives = 146/198 (73%), Gaps = 3/198 (1%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
M LL SVILIS +S+VGGE T CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
SPSKSFWTRITCTEEGWSPTPKCLR+C FPFV+NGHSESSG HLEGDTVQIICNTGY L
Sbjct: 61 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNEKNISCVERGWSTPPICSFT--KGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK 177
QNNE NISCVERGWSTPP C T G+C P N D S Y +++ C+
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180
Query: 178 NLIRVGSDSVQCYQFGWS 195
G+ + C WS
Sbjct: 181 LYQLEGNKRITCRNGQWS 198
Score = 177 bits (448), Expect = 3e-44
Identities = 86/201 (42%), Positives = 119/201 (59%), Gaps = 13/201 (6%)
Query: 379 VDCTEKREQFCPPP--------PQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE-I 429
+ CTE E + P P P + N + ++ + +G+ V ++C Y L + I
Sbjct: 70 ITCTE--EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
Query: 430 VCKDGRWQSLPRC--VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGS 487
C + W + P+C +ST CGPPP I+NGD TSFPLSVY P S+V Y+CQ+ Y+L+G+
Sbjct: 128 SCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 187
Query: 488 VTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKA 547
+TCRN QWSEPP+CL PCV+S E M NI L+W KLY +TG++ EF CK ++
Sbjct: 188 KRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
Query: 548 MISSPPFRAICQEGKFEYPIC 568
S R C +GK EYP C
Sbjct: 248 SSRSHTLRTTCWDGKLEYPTC 268
Score = 77.8 bits (190), Expect = 2e-14
Identities = 65/233 (27%), Positives = 98/233 (42%), Gaps = 26/233 (11%)
Query: 162 KESYK------VGDVLKFSCRKNLIRVGSD---SVQCYQFGWSPNFPTCKGQVRSCGPPP 212
+E YK G+V +SC N + + C + GWSP P C +R C P
Sbjct: 36 EEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPT-PKC---LRLCFFP- 90
Query: 213 QLSNGEVKEIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTC--VEQVKTC 269
+ NG E + + + V+ CN + + N I CV+ W+T P C + C
Sbjct: 91 FVENGH-SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKC 149
Query: 270 GYIPELEYGYVQP-SVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQL 328
G P ++ G + + Y SVE C+N Y + GN ITC NG W+E P C+ +
Sbjct: 150 GPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVI 209
Query: 329 KRCKIAGVNI-------KTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGK 374
R + NI + L +G+ + YR S + C +GK
Sbjct: 210 SREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 262
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/144 (28%), Positives = 61/144 (42%), Gaps = 14/144 (9%)
Query: 70 ITCTEEGWSPTPKCLRMCSF------PFVKNGHSESSGL-IHLEGDTVQIICNTGYSLQN 122
I+C E GWS PKC S P + NG S L ++ +V+ C Y L+
Sbjct: 127 ISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG 186
Query: 123 NEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQ--PKKESY-KVGDVLKFSCRKNL 179
N K I+C WS PP C + N+ + K++ Y + G+ +F C++
Sbjct: 187 N-KRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRG- 244
Query: 180 IRVGSDSVQCYQFGWSP--NFPTC 201
R+ S S W +PTC
Sbjct: 245 YRLSSRSHTLRTTCWDGKLEYPTC 268
Score = 33.5 bits (75), Expect = 0.54
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 7/66 (10%)
Query: 69 RITCTEEGWSPTPKCLRMC--SFPFVKNGH-----SESSGLIHLEGDTVQIICNTGYSLQ 121
RITC WS PKCL C S ++N + + L G++ + +C GY L
Sbjct: 189 RITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLS 248
Query: 122 NNEKNI 127
+ +
Sbjct: 249 SRSHTL 254
>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
Length = 270
Score = 267 bits (682), Expect = 2e-71
Identities = 131/198 (66%), Positives = 146/198 (73%), Gaps = 3/198 (1%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
M LL SVILIS +S+VGGE CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
SPSKSFWTRITC EEGWSPTPKCLR+C FPFV+NGHSESSG HLEGDTVQIICNTGY L
Sbjct: 61 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
Query: 121 QNNEKNISCVERGWSTPPIC--SFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK 177
QNNE NISCVERGWSTPP C + + +C P N D S Y G +++ C+
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
Query: 178 NLIRVGSDSVQCYQFGWS 195
G++ + C WS
Sbjct: 181 LYQLEGNNQITCRNGQWS 198
Score = 185 bits (469), Expect = 1e-46
Identities = 94/203 (46%), Positives = 124/203 (61%), Gaps = 9/203 (4%)
Query: 370 CINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE- 428
C W+P C R F P + N + ++ + +G+ V ++C Y L +
Sbjct: 72 CAEEGWSPTPKCL--RLCFFP---FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
Query: 429 IVCKDGRWQSLPRCVE--STAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG 486
I C + W + P+C S CGPPP I+NGD TSF LSVY PGS+V Y+CQ+ Y+L+G
Sbjct: 127 ISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEG 186
Query: 487 SVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHK 546
+ +TCRN QWSEPP+CLDPCV+S+E M K NI+LKW N KLY++TGD VEF CK +
Sbjct: 187 NNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYH 246
Query: 547 AMISSPPFRAICQEGKFEYPICE 569
S FRA+CQ GK YP CE
Sbjct: 247 P-TKSHSFRAMCQNGKLVYPSCE 268
Score = 81.6 bits (200), Expect = 2e-15
Identities = 65/225 (28%), Positives = 100/225 (44%), Gaps = 29/225 (12%)
Query: 162 KESYK------VGDVLKFSCRKNLIRVGSD---SVQCYQFGWSPNFPTCKGQVRSCGPPP 212
+E YK G+V +SC N + + C + GWSP P C +R C P
Sbjct: 36 EEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPT-PKC---LRLCFFP- 90
Query: 213 QLSNGEVKEIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTCVEQVKT--C 269
+ NG E + + + V+ CN + + N I CV+ W+T P C + C
Sbjct: 91 FVENGH-SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKC 149
Query: 270 GYIPELEYGYVQPSV-PPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQL 328
G P ++ G + + Y G SVE C+N Y + GNN ITC NG W+E P C+ +
Sbjct: 150 GPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVI 209
Query: 329 KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCING 373
+ + NIK ++ + ++ R DI + VC +G
Sbjct: 210 SQEIMEKYNIKL-------KWTNQQKLYSRTGDIVEF---VCKSG 244
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 7/79 (8%)
Query: 69 RITCTEEGWSPTPKCLRMCSFP-------FVKNGHSESSGLIHLEGDTVQIICNTGYSLQ 121
+ITC WS PKCL C +K + L GD V+ +C +GY
Sbjct: 189 QITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPT 248
Query: 122 NNEKNISCVERGWSTPPIC 140
+ + + G P C
Sbjct: 249 KSHSFRAMCQNGKLVYPSC 267
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 7/62 (11%)
Query: 453 PSINNG---DTTSF-PLSVYPPGSTVTYRCQ-SFYKLQGS--VTVTCRNKQWSEPPRCLD 505
P IN+G D + P S P G Y C+ +F S +TC + WS P+CL
Sbjct: 26 PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR 85
Query: 506 PC 507
C
Sbjct: 86 LC 87
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 200 bits (508), Expect = 3e-51
Identities = 113/319 (35%), Positives = 166/319 (52%), Gaps = 19/319 (5%)
Query: 264 EQVKTCGYIPELEYG-----YVQPSVPPYQHGVSVEVNCRNEYAMIGNNM---ITCINGI 315
++VK C + PE+++G ++ P G S C + + I C
Sbjct: 19 QEVKPCDF-PEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDG 77
Query: 316 WTELPMCVATHQLKRCKIAG--VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCING 373
W+ C+ T +I ++ + + + KE + + Y +D C+
Sbjct: 78 WSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQN 137
Query: 374 KWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK---EIV 430
W+ + C + FC P N++ + + ++ + + C + Y + IV
Sbjct: 138 GWSAQPICIK----FCDMPV-FENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIV 192
Query: 431 CKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTV 490
C + W P C S+ CGPPP I+NGDTTSF L VY P S V Y+CQS+Y+LQGS V
Sbjct: 193 CGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYV 252
Query: 491 TCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMIS 550
TC N +WSEPPRC+ PC+++EENMNKNNIQLK ++D K YAKTGD +EF CK + A S
Sbjct: 253 TCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTS 312
Query: 551 SPPFRAICQEGKFEYPICE 569
F+A+C+EG EYP CE
Sbjct: 313 VLSFQAVCREGIVEYPRCE 331
Score = 181 bits (459), Expect = 2e-45
Identities = 100/271 (36%), Positives = 142/271 (52%), Gaps = 13/271 (4%)
Query: 1 MLLLFSVILISWVSTVGGEGTL-CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNF 59
MLLL +VIL WVS G+ CDFP+I HG LY + + G+ + Y C+ NF
Sbjct: 1 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 60
Query: 60 VSPSKSFWTRITCTEEGWSPTPKCLRMCSFP--FVKNGHSESSGLIHLEGDTVQIICNTG 117
V+PS S+W I CT++GWSPT CLR CS ++NG S I++ +Q C G
Sbjct: 61 VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG 120
Query: 118 YSLQ--NNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSC 175
Y+ N+ +I+C++ GWS PIC C +P+ E N A+ +K+ D L + C
Sbjct: 121 YATADGNSSGSITCLQNGWSAQPICI---KFCDMPVFE-NSRAKSNGMRFKLHDTLDYEC 176
Query: 176 RKNL-IRVG--SDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEV 232
I G + S+ C + GWS +FPTC CGPPP +SNG+ + Y
Sbjct: 177 YDGYEISYGNTTGSIVCGEDGWS-HFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSR 235
Query: 233 VEYDCNPNFIINGPKKIQCVDGEWTTLPTCV 263
VEY C + + G + C +GEW+ P C+
Sbjct: 236 VEYQCQSYYELQGSNYVTCSNGEWSEPPRCI 266
Score = 77.0 bits (188), Expect = 4e-14
Identities = 68/279 (24%), Positives = 110/279 (39%), Gaps = 28/279 (10%)
Query: 84 LRMCSFPFVKNGHSESSGLIHL-----EGDTVQIICNTGYSLQNNE--KNISCVERGWST 136
++ C FP +++G L L G + C+ + + I C + GWS
Sbjct: 21 VKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSP 80
Query: 137 PPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRV---GSDSVQCYQFG 193
C T + + I N Y + +++ C+ S S+ C Q G
Sbjct: 81 TVPCLRTCSKSDIEI--ENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNG 138
Query: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFII---NGPKKIQ 250
WS P C ++ C P N K + ++ ++Y+C + I N I
Sbjct: 139 WSAQ-PIC---IKFCDMPV-FENSRAKS-NGMRFKLHDTLDYECYDGYEISYGNTTGSIV 192
Query: 251 CVDGEWTTLPTCVEQVKTCGYIPELEYGYVQP-SVPPYQHGVSVEVNCRNEYAMIGNNMI 309
C + W+ PTC + CG P + G + Y VE C++ Y + G+N +
Sbjct: 193 CGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYV 252
Query: 310 TCINGIWTELPMCVATHQLKRCKIAGVNI-KTLLKLSGK 347
TC NG W+E P C+ C I N+ K ++L GK
Sbjct: 253 TCSNGEWSEPPRCI-----HPCIITEENMNKNNIQLKGK 286
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/87 (20%), Positives = 38/87 (43%), Gaps = 10/87 (11%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMC--SFPFVKNGHSESSGLIHLE---- 106
Y C+ + ++ +TC+ WS P+C+ C + + + + G ++
Sbjct: 238 YQCQSYYELQGSNY---VTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAK 294
Query: 107 -GDTVQIICNTGYSLQNNEKNISCVER 132
GDT++ +C GY+ + + V R
Sbjct: 295 TGDTIEFMCKLGYNANTSVLSFQAVCR 321
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 194 bits (493), Expect = 2e-49
Identities = 92/266 (34%), Positives = 137/266 (51%), Gaps = 4/266 (1%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60
MLLL +VIL WVS G+ CDFP I HG L+ E P+ V G+ + Y C+ +F
Sbjct: 1 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 60
Query: 61 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
+PS S+W I CT+ GWSP CLR C FP+++NG++++ G ++G++ ++ C+ GY L
Sbjct: 61 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 120
Query: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI 180
+ ++C E+GWS P C + I N Y + +++ C+
Sbjct: 121 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYA 180
Query: 181 RV---GSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDC 237
S S+ C Q GWS P C CGPPP +SNG+ + Y VEY C
Sbjct: 181 TADGNSSGSITCLQNGWSAQ-PICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQC 239
Query: 238 NPNFIINGPKKIQCVDGEWTTLPTCV 263
P + + G + C +GEW+ P C+
Sbjct: 240 QPYYELQGSNYVTCSNGEWSEPPRCI 265
Score = 190 bits (482), Expect = 3e-48
Identities = 94/204 (46%), Positives = 121/204 (59%), Gaps = 6/204 (2%)
Query: 370 CINGKWNPEVDCTEKREQFCPPPP-QIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE 428
C W+P C R C +I N ++ Y +++ CK Y +
Sbjct: 129 CTEKGWSPTPRCIRVRT--CSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNS 186
Query: 429 ---IVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQ 485
I C W + P C+ S+ CGPPP I+NGDTTSF L VY P S V Y+CQ +Y+LQ
Sbjct: 187 SGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQ 246
Query: 486 GSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPH 545
GS VTC N +WSEPPRC+ PC+++EENMNKNNI+LK R+D K YAKTGD +EF CK +
Sbjct: 247 GSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Query: 546 KAMISSPPFRAICQEGKFEYPICE 569
A S F+A+C+EG EYP CE
Sbjct: 307 NANTSILSFQAVCREGIVEYPRCE 330
Score = 87.4 bits (215), Expect = 3e-17
Identities = 74/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)
Query: 84 LRMCSFPFVKNGHSESSGLIHLE----------GDTVQIICNTGYSLQNNE--KNISCVE 131
++ C FP +K+G GL H G C+ + + I C +
Sbjct: 20 VKPCDFPDIKHG-----GLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQ 74
Query: 132 RGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL-IRVGSDSVQCY 190
GWS C +C+ P LE + Q + G+ + +C + +V C
Sbjct: 75 NGWSPAVPCL---RKCYFPYLENGYN-QNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCT 130
Query: 191 QFGWSPNFPTCKGQVRSCGPPP-QLSNGEVKEIRKEEYGHNEVVEYDCNPNFII---NGP 246
+ GWSP P C +VR+C ++ NG + E Y N+ ++Y C P + N
Sbjct: 131 EKGWSPT-PRCI-RVRTCSKSDIEIENGFISE-SSSIYILNKEIQYKCKPGYATADGNSS 187
Query: 247 KKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSV-PPYQHGVSVEVNCRNEYAMIG 305
I C+ W+ P C+ + CG P + G + Y VE C+ Y + G
Sbjct: 188 GSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQG 247
Query: 306 NNMITCINGIWTELPMCVATHQLKRCKIAGVNI-KTLLKLSGK 347
+N +TC NG W+E P C+ C I N+ K +KL G+
Sbjct: 248 SNYVTCSNGEWSEPPRCI-----HPCIITEENMNKNNIKLKGR 285
Score = 80.9 bits (198), Expect = 3e-15
Identities = 75/321 (23%), Positives = 117/321 (36%), Gaps = 29/321 (9%)
Query: 203 GQVRSCGPPPQLSNGEVKEIRKEEY---GHNEVVEYDCNPNFIINGPKK---IQCVDGEW 256
GQV+ C P G E + Y + Y C+ +F I C W
Sbjct: 18 GQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGW 77
Query: 257 TTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMI-GNNMITCINGI 315
+ C+ + Y P LE GY Q + G S EV C Y + +TC
Sbjct: 78 SPAVPCLRKC----YFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKG 133
Query: 316 WTELPMCVATHQLKRCKIAGVNIKT-LLKLSGKEFNHNSRIRYRCSDIFRYRHS------ 368
W+ P C+ +++ C + + I+ + S + N I+Y+C +
Sbjct: 134 WSPTPRCI---RVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSI 190
Query: 369 VCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCKENYLLPEAK 427
C+ W+ + C E+ PPPP I N + + Y +V C+ Y L +
Sbjct: 191 TCLQNGWSAQPICINSSEKCGPPPP-ISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSN 249
Query: 428 EIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVY--PPGSTVTYRCQSFYKLQ 485
+ C +G W PRC+ + NN Y G T+ + C+ Y
Sbjct: 250 YVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNAN 309
Query: 486 GSV---TVTCRNKQWSEPPRC 503
S+ CR + E PRC
Sbjct: 310 TSILSFQAVCR-EGIVEYPRC 329
Score = 40.0 bits (92), Expect = 0.006
Identities = 36/164 (21%), Positives = 62/164 (37%), Gaps = 13/164 (7%)
Query: 410 GEKVAVLCKENYLLPEAKE---IVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS 466
G+ + C E++ P I C W C+ + P + NG ++
Sbjct: 48 GKYYSYYCDEHFETPSGSYWDYIHCTQNGWSPAVPCLRKCYF----PYLENGYNQNYGRK 103
Query: 467 VYPPGSTVTYRCQSFYKL-QGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRN 525
+ G++ C Y L + TVTC K WS PRC+ S+ ++ N +
Sbjct: 104 -FVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFIS--E 160
Query: 526 DGKLYAKTGDAVEFQCKFPHKAMISSPPFRAIC-QEGKFEYPIC 568
+Y + ++++CK + + C Q G PIC
Sbjct: 161 SSSIYILNKE-IQYKCKPGYATADGNSSGSITCLQNGWSAQPIC 203
Score = 30.8 bits (68), Expect = 3.5
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 12/88 (13%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFP---FVKN-----GHSESSGLIH 104
Y C+ + ++ +TC+ WS P+C+ C KN G S+
Sbjct: 237 YQCQPYYELQGSNY---VTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRK-YYA 292
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVER 132
GDT++ +C GY+ + + V R
Sbjct: 293 KTGDTIEFMCKLGYNANTSILSFQAVCR 320
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 127 bits (319), Expect = 3e-29
Identities = 127/486 (26%), Positives = 208/486 (42%), Gaps = 53/486 (10%)
Query: 23 CDFPKI-HHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWS-PT 80
CD P +GFL F++ G YSC+ + R+ WS +
Sbjct: 2717 CDLPTAPENGFLR-------FTETSMGSAVQYSCKPGHILAGSDL--RLCLENRKWSGAS 2767
Query: 81 PKCLRM-CSFPF-VKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP- 137
P+C + C P V NG + S +L T+ C+ GY L E+ ++ W
Sbjct: 2768 PRCEAISCKKPNPVMNGSIKGSNYTYLS--TLYYECDPGYVLNGTERRTCQDDKNWDEDE 2825
Query: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSP 196
PIC +C P + AN Q + + Y ++++C + + G+ S C G WS
Sbjct: 2826 PIC--IPVDCSSPPVSAN--GQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Query: 197 NFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGE 255
P C VR C PPQL+NG + + +YG + V + C+ +I++G K+ C DG
Sbjct: 2882 ATPDCV-PVR-CATPPQLANGVTEGL---DYGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
Query: 256 WTT-LPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-N 313
W +P C + CG +L +G+ P+ + HG ++ C Y + GN+ C+ N
Sbjct: 2937 WDAEIPLC--KPVNCGPPEDLAHGF--PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSN 2992
Query: 314 GIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRY---RHSV 369
G W+ P C+ RC + T+ +G +F+ R +C F+
Sbjct: 2993 GSWSGSSPSCLPC----RCSTPVIEYGTV---NGTDFDCGKAARIQCFKGFKLLGLSEIT 3045
Query: 370 C-INGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE 428
C +G+W+ E C P IPNA ++ T ++++ + C+ Y++ + +
Sbjct: 3046 CEADGQWSSGFPHCEHTS--CGSLPMIPNAF-ISETSSWKENV-ITYSCRSGYVIQGSSD 3101
Query: 429 IVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSV 488
++C + S P V CG PPS+ N T + S V RC Y +
Sbjct: 3102 LICTEKGVWSQPYPVCEPLSCGSPPSVANAVATG---EAHTYESEVKLRCLEGYTMDTDT 3158
Query: 489 -TVTCR 493
T TC+
Sbjct: 3159 DTFTCQ 3164
Score = 116 bits (291), Expect = 5e-26
Identities = 129/490 (26%), Positives = 198/490 (40%), Gaps = 55/490 (11%)
Query: 40 NPFSQVPTGEVFYYSCEYNFVSPSKSFW----TRITCTEEG-WSPT-PKCLRM-CSFPFV 92
NP + +GE++ E F S + + T+ITC E G W+ P C + C P +
Sbjct: 1794 NPENGHSSGEIYTVGAEVTF-SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAI 1852
Query: 93 -KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWS-TPPICSFTKGECHVP 150
+NG E L G V CN GY+L ++++ WS +PP+C K C P
Sbjct: 1853 PENGCIEE--LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK--CSSP 1908
Query: 151 ILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCG 209
E + + +SC G ++C G W P C + CG
Sbjct: 1909 --ENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPAC--HLVFCG 1964
Query: 210 PPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTTLPTCVEQVKT 268
PP + + I + V Y C + + G I+C+ DG+W+ V +
Sbjct: 1965 EPPAIKDA---VITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAV-S 2020
Query: 269 CGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWT-----ELPMC 322
C P ++ + P G C + Y++ N+ + C G W ++P C
Sbjct: 2021 CDEPPIVD--HASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
Query: 323 VATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNP- 377
+A H + K V+ L +S +F S + ++C + F S I G+WNP
Sbjct: 2079 IA-HFCE--KPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPS 2135
Query: 378 --EVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DG 434
+ C R C PP I N + NY G VA C + + + K+ C+ G
Sbjct: 2136 PMSIQCIPVR---CGEPPSIMN--GYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATG 2190
Query: 435 RWQS-LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR 493
+W S +P C CG PP + NG ++ S V Y+C YK GS C+
Sbjct: 2191 QWSSPIPTC--HPVSCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQ 2246
Query: 494 -NKQW-SEPP 501
N+ W SE P
Sbjct: 2247 ANRHWHSESP 2256
Score = 111 bits (278), Expect = 2e-24
Identities = 121/461 (26%), Positives = 192/461 (41%), Gaps = 62/461 (13%)
Query: 70 ITCTEEG-WSPT-PKCLRM-CSFPFV-KNGH---SESSGLIHLEGDTVQIICNTGYSLQN 122
+ C E+G W+ + P C+ + C P +NG +E+S G VQ C G+ L
Sbjct: 2697 LICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETS-----MGSAVQYSCKPGHILAG 2751
Query: 123 NEKNISCVERGWS-TPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIR 181
++ + R WS P C + P++ ++ K +Y L + C +
Sbjct: 2752 SDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSI----KGSNYTYLSTLYYECDPGYVL 2807
Query: 182 VGSDSVQCYQF-GWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN 240
G++ C W + P C C PP +NG+V R +EY + +EY CN
Sbjct: 2808 NGTERRTCQDDKNWDEDEPICIPV--DCSSPPVSANGQV---RGDEYTFQKEIEYTCNEG 2862
Query: 241 FIINGPKKIQCV-DGEWT-TLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCR 298
F++ G + C+ +G W+ P CV C P+L G + Y V +C
Sbjct: 2863 FLLEGARSRVCLANGSWSGATPDCVP--VRCATPPQLANGVTEGL--DYGFMKEVTFHCH 2918
Query: 299 NEYAMIGNNMITC-INGIW-TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIR 356
Y + G +TC +G W E+P+C K +G F H I+
Sbjct: 2919 EGYILHGAPKLTCQSDGNWDAEIPLC------KPVNCGPPEDLAHGFPNGFSFIHGGHIQ 2972
Query: 357 YRCSDIFRYRHSV---CI-NGKWN-PEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGE 411
Y+C ++ + C+ NG W+ C R C P N T ++ G+
Sbjct: 2973 YQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCR---CSTPVIEYGTVNGT---DFDCGK 3026
Query: 412 KVAVLCKENYLLPEAKEIVCK-DGRWQS-LPRCVESTAYCGPPPSINN---GDTTSFPLS 466
+ C + + L EI C+ DG+W S P C ++ CG P I N +T+S+ +
Sbjct: 3027 AARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTS--CGSLPMIPNAFISETSSWKEN 3084
Query: 467 VYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWSEPPRCLDP 506
V +TY C+S Y +QGS + C K WS+P +P
Sbjct: 3085 V------ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEP 3119
Score = 107 bits (266), Expect = 4e-23
Identities = 119/471 (25%), Positives = 185/471 (39%), Gaps = 52/471 (11%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEG-WSPTPKCLRMCSF---PFVKNGHSESSGLIHLEGD 108
YSC+ + S I CT G W P + P +K+ + +
Sbjct: 1929 YSCDTGYSLQGPSI---IECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFR--N 1983
Query: 109 TVQIICNTGYSLQNNEKNISCVERG-WSTPPICSFTKGECHVPILEANVDAQPKKESYKV 167
TV C GY+L + I C+ G WS PI++ A P+
Sbjct: 1984 TVTYTCKEGYTLAGLD-TIECLADGKWSRSDQQCLAVSCDEPPIVD---HASPETAHRLF 2039
Query: 168 GDVLKFSCRKNLIRVGSDSVQCYQFG-WSP----NFPTCKGQVRSCGPPPQLSNGEVKEI 222
GD+ + C + + C G W P + P C C PP +S ++ +
Sbjct: 2040 GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHF--CEKPPSVSYSILESV 2097
Query: 223 RKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTTLPTCVEQVKT-CGYIPELEYGYV 280
K ++ VV + C F++N KI+C+ G+W P ++ + CG P + GY
Sbjct: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYA 2157
Query: 281 QPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATHQLKRCKIAGVNI 338
S Y G V +C + + G TC G W+ +P C H + + V
Sbjct: 2158 SGS--NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC---HPVSCGEPPKVEN 2212
Query: 339 KTLLKLSGKEFNHNSRIRYRCSDIFRYRHS---VC-INGKWNPE--VDCTEKREQFCPPP 392
L +G+ F S +RY+C+ ++ S VC N W+ E + C C P
Sbjct: 2213 GFLEHTTGRIF--ESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLD---CGKP 2267
Query: 393 PQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRW--QSLPRCVESTAYC 449
P I N N++ G KV C E Y L C K G+W +S P+C+ A C
Sbjct: 2268 PPIQN--GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCM--PAKC 2323
Query: 450 GPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSE 499
PP + N + VT+ C+ + LQG + C ++QW++
Sbjct: 2324 PEPPLLENQLVLK---ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWND 2371
Score = 99.0 bits (245), Expect = 1e-20
Identities = 120/486 (24%), Positives = 183/486 (37%), Gaps = 52/486 (10%)
Query: 39 YNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKC--LRMCSFPFVKN 94
Y S G + YSC F + + TC G WS P P C + P V+N
Sbjct: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEK---KSTCEATGQWSSPIPTCHPVSCGEPPKVEN 2212
Query: 95 GHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEA 154
G E + E + V+ CN GY + + R W + +C P
Sbjct: 2213 GFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQ 2271
Query: 155 NVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQL 214
N K E+++VG ++F C + VG S C + G K C PP L
Sbjct: 2272 N--GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLL 2329
Query: 215 SNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGE-WT-TLPTCVEQVKTCGYI 272
N V + E G VV + C ++ GP ++C+ + W + P C ++ C
Sbjct: 2330 ENQLVLKELTTEVG---VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC--KIVLCTPP 2384
Query: 273 PELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTE-LPMCVATH--QL 328
P + +G PS G +V+ +C + + GN+ C +G W+ LP CV Q
Sbjct: 2385 PLISFGVPIPS-SALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQP 2443
Query: 329 KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKW---NPEVDC 381
+ ++++ L LS Y C F + NG W P
Sbjct: 2444 EEIPNGIIDVQGLAYLS--------TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKA 2495
Query: 382 TEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKD-GRWQ-SL 439
E C P +I N + T ++Y G+ V C + L + C + G W
Sbjct: 2496 IE-----CLKPKEILNGKFSYTDLHY--GQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548
Query: 440 PRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSE 499
P C + +C P I NG + Y G+ + Y C +++ G TC WS
Sbjct: 2549 PSC--NAIHCDSPQPIENGFVEG---ADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSS 2603
Query: 500 P-PRCL 504
P C+
Sbjct: 2604 SIPTCM 2609
Score = 92.4 bits (228), Expect = 1e-18
Identities = 133/582 (22%), Positives = 210/582 (36%), Gaps = 104/582 (17%)
Query: 26 PKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR 85
PK+ +GFL + TG +F Y KS + + + +
Sbjct: 2208 PKVENGFL----------EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPL 2257
Query: 86 MC------SFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERG-WSTPP 138
MC P ++NG + G VQ CN GY L + + +C + G W+
Sbjct: 2258 MCVPLDCGKPPPIQNGFMKGENFE--VGSKVQFFCNEGYELVG-DSSWTCQKSGKWNKKS 2314
Query: 139 ICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPN 197
+C P L N K+ + +VG V+ FSC++ + G ++C W+ +
Sbjct: 2315 NPKCMPAKCPEPPLLEN-QLVLKELTTEVG-VVTFSCKEGHVLQGPSVLKCLPSQQWNDS 2372
Query: 198 FPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEW 256
FP CK + C PPP +S G +G V+Y C F + G C DG W
Sbjct: 2373 FPVCK--IVLCTPPPLISFGVPIPSSALHFG--STVKYSCVGGFFLRGNSTTLCQPDGTW 2428
Query: 257 TT-LPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-ING 314
++ LP CV C E+ G + Y + C+ + ++GN C NG
Sbjct: 2429 SSPLPECVPV--ECPQPEEIPNGIIDVQGLAYLS--TALYTCKPGFELVGNTTTLCGENG 2484
Query: 315 IWTE-LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN- 372
W P C A LK +I K S + ++ + Y C+ FR +
Sbjct: 2485 HWLGGKPTCKAIECLKPKEILNG------KFSYTDLHYGQTVTYSCNRGFRLEGPSALTC 2538
Query: 373 ---GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEI 429
G W +VD C P I N +Y G + C + +
Sbjct: 2539 LETGDW--DVDAPSCNAIHCDSPQPIENG--FVEGADYSYGAIIIYSCFPGFQVAGHAMQ 2594
Query: 430 VCKDGRWQS-LPRCVESTAYCGPPPSINNGDTTSFP-----------------LSVYPP- 470
C++ W S +P C+ CG PP I+ GD T ++ +PP
Sbjct: 2595 TCEESGWSSSIPTCMPID--CGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPY 2652
Query: 471 -------------------------GSTVTYRCQSFYKLQGSVTVTCR-NKQWS-EPPRC 503
G+ V+Y C Y+L G+ + C+ + W+ P C
Sbjct: 2653 HLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSC 2712
Query: 504 LDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPH 545
+ + + N L++ G AV++ CK H
Sbjct: 2713 IS--IECDLPTAPENGFLRFTE-----TSMGSAVQYSCKPGH 2747
Score = 92.0 bits (227), Expect = 1e-18
Identities = 122/465 (26%), Positives = 188/465 (40%), Gaps = 59/465 (12%)
Query: 68 TRITCTEEG-WSPT-PKCLRMC--SFPFVKNGH-SESSGLIHLEGDTVQIICNTGYSLQN 122
+ ITC +G WS P C S P + N SE+S + + + C +GY +Q
Sbjct: 3042 SEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSW---KENVITYSCRSGYVIQG 3098
Query: 123 NEKNISCVERG-WSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL- 179
+ ++ C E+G WS P P+C C P AN A + +Y+ +K C +
Sbjct: 3099 SS-DLICTEKGVWSQPYPVCEPLS--CGSPPSVANAVATGEAHTYE--SEVKLRCLEGYT 3153
Query: 180 IRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCN 238
+ +D+ C + G W P +C + C P +++ V +++ N V C
Sbjct: 3154 MDTDTDTFTCQKDGRWFPERISCSP--KKCPLPENITHILV---HGDDFSVNRQVSVSCA 3208
Query: 239 PNFIINGPKKIQC-VDGEWTTLPTCVEQVK--TCGYIPELEYGYVQPSVPPYQHGVSVEV 295
+ G C +DG W P E +CG E+G+V S Y ++
Sbjct: 3209 EGYTFEGVNISVCQLDGTWEP-PFSDESCSPVSCGKPESPEHGFVVGS--KYTFESTIIY 3265
Query: 296 NCRNEYAMIGNNMITCI-NGIWTE-LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNS 353
C Y + GN C N W+ + +C T RC+ L L+GK N
Sbjct: 3266 QCEPGYELEGNRERVCQENRQWSGGVAICKET----RCETP------LEFLNGKADIENR 3315
Query: 354 ----RIRYRCSDIFRYR---HSVCI-NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTV 405
+ Y C+ + + C NG W+ V + CP P IP ++
Sbjct: 3316 TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNP--CPVPFVIPENALLSEKE 3373
Query: 406 NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCGPPPSINNGDTTSF 463
Y D + V++ C+E +LL I C D W Q+ +C + + CGPP + N
Sbjct: 3374 FYVD-QNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS--CGPPAHVENAIARGV 3430
Query: 464 PLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEPPRCLDPC 507
Y G +TY C S Y L+G + C N W+ PP C C
Sbjct: 3431 H---YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472
Score = 85.9 bits (211), Expect = 9e-17
Identities = 95/385 (24%), Positives = 144/385 (37%), Gaps = 69/385 (17%)
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
E K G + C VG+ C G W+ P C+ SCG PP L NG
Sbjct: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERI--SCGVPPPLENGFHS- 1702
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQCVD-GEWTTL-PTCVEQVKTCGYIPE----- 274
+++ V Y CN + + G ++ C D G W + P+C++ V C +
Sbjct: 1703 --ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLD-VDECAVGSDCSEHA 1759
Query: 275 ----LEYGYVQPSVPPYQH-----------------------------GVSVEVNCRNEY 301
++ Y+ VPPY G V +C+ Y
Sbjct: 1760 SCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGY 1819
Query: 302 AMIGNNMITCI-NGIWTEL-PMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRC 359
++G ITC+ +G W L P C A K I+ L F S++ YRC
Sbjct: 1820 QLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEEL------AFTFGSKVTYRC 1873
Query: 360 SDIFRY---RHSVCI-NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAV 415
+ + + S C+ N W+ E + C P I N + + + + Y +
Sbjct: 1874 NKGYTLAGDKESSCLANSSWSHSPPVCEPVK--CSSPENINNGKYILSGLTYL--STASY 1929
Query: 416 LCKENYLLPEAKEIVC-KDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTV 474
C Y L I C G W P +CG PP+I + T + + +TV
Sbjct: 1930 SCDTGYSLQGPSIIECTASGIWDRAPPACH-LVFCGEPPAIKDAVITG---NNFTFRNTV 1985
Query: 475 TYRCQSFYKLQGSVTVTC-RNKQWS 498
TY C+ Y L G T+ C + +WS
Sbjct: 1986 TYTCKEGYTLAGLDTIECLADGKWS 2010
Score = 84.0 bits (206), Expect = 3e-16
Identities = 93/320 (29%), Positives = 132/320 (41%), Gaps = 47/320 (14%)
Query: 208 CGPPPQLSNGEVKEIR--KEEYGHNEVVEYDCNPNFIINGPKKIQCVD-GEWTT-LPTCV 263
C P+L G V +R E+ V C+P F + G C++ G+WT LP C
Sbjct: 1628 CSDCPRLG-GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHC- 1685
Query: 264 EQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTEL-PM 321
E++ +CG P LE G+ S + G +V C N Y ++G++ + C NG W + P
Sbjct: 1686 ERI-SCGVPPPLENGF--HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPS 1742
Query: 322 CVATHQLKRCKIAG--VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEV 379
C+ + C + + L + G Y CS + Y +GK
Sbjct: 1743 CL---DVDECAVGSDCSEHASCLNVDGS---------YICSCVPPYTG----DGK----- 1781
Query: 380 DCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS 438
+C E + P P+ ++ TV G +V C+E Y L +I C + G W
Sbjct: 1782 NCAEPIKCKAPGNPENGHSSGEIYTV----GAEVTFSCQEGYQLMGVTKITCLESGEWNH 1837
Query: 439 L-PRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQ 496
L P C CG P NG + GS VTYRC Y L G +C N
Sbjct: 1838 LIPYC--KAVSCGKPAIPENGCIEELAFTF---GSKVTYRCNKGYTLAGDKESSCLANSS 1892
Query: 497 WS-EPPRCLDPCVVSEENMN 515
WS PP C S EN+N
Sbjct: 1893 WSHSPPVCEPVKCSSPENIN 1912
Score = 83.6 bits (205), Expect = 5e-16
Identities = 126/543 (23%), Positives = 195/543 (35%), Gaps = 101/543 (18%)
Query: 23 CDFPK-IHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPT- 80
CD P+ I +GF+ + DY+ G + YSC F + T C E GWS +
Sbjct: 2556 CDSPQPIENGFV-EGADYS------YGAIIIYSCFPGFQVAGHAMQT---CEESGWSSSI 2605
Query: 81 PKCLR-----------------------------MCSFPFVKNG-------------HSE 98
P C+ M P+V +++
Sbjct: 2606 PTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTK 2665
Query: 99 SSGLIH----LEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEA 154
S H L G V CN GY L N I C E G S EC +P
Sbjct: 2666 ESPATHSSNFLYGTMVSYTCNPGYELLGNPVLI-CQEDGTWNGSAPSCISIECDLPTAPE 2724
Query: 155 NVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQ 213
N + + S +G +++SC+ I GSD C + WS P C + SC P
Sbjct: 2725 NGFLRFTETS--MGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRC--EAISCKKPNP 2780
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGE-W-TTLPTCVEQVKTCGY 271
+ NG +K Y + + Y+C+P +++NG ++ C D + W P C+ C
Sbjct: 2781 VMNGSIK---GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIP--VDCSS 2835
Query: 272 IPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLK 329
P G V+ +Q +E C + + G C+ NG W+ P CV
Sbjct: 2836 PPVSANGQVRGDEYTFQK--EIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCAT 2893
Query: 330 RCKIA-GVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEVDCTEK 384
++A GV G ++ + + C + + + + +G W+ E+ +
Sbjct: 2894 PPQLANGVT-------EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKP 2946
Query: 385 REQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQ-SLPRC 442
C PP + A ++ G + C Y L C +G W S P C
Sbjct: 2947 VN--CGPPEDL--AHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC 3002
Query: 443 VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQWSEP- 500
+ P I G + + G +C +KL G +TC + QWS
Sbjct: 3003 LPCRC---STPVIEYGTVNG---TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGF 3056
Query: 501 PRC 503
P C
Sbjct: 3057 PHC 3059
Score = 83.2 bits (204), Expect = 6e-16
Identities = 122/534 (22%), Positives = 187/534 (35%), Gaps = 100/534 (18%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-----PKCL-RMCSFP-FVKNGHSES 99
G++ +Y C + S ++ C +G W P P+C+ C P V ES
Sbjct: 2040 GDIAFYYCSDGYSLADNS---QLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILES 2096
Query: 100 -SGLIHLEGDTVQIICNTGYSLQNNEKNISCVERG-WSTPPIC-SFTKGECHVPILEANV 156
S G V C G+ L + K I C+ G W+ P+ C P + +
Sbjct: 2097 VSKAKFAAGSVVSFKCMEGFVLNTSAK-IECMRGGQWNPSPMSIQCIPVRCGEP--PSIM 2153
Query: 157 DAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLS 215
+ +Y G ++ +SC K G C G WS PTC SCG PP++
Sbjct: 2154 NGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPV--SCGEPPKVE 2211
Query: 216 NGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTTLPTCVEQVKTCGYIPE 274
NG ++ + V Y CNP + G C + W + + CG P
Sbjct: 2212 NGFLEHTTGRIF--ESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPP 2269
Query: 275 LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTEL--PMC--------- 322
++ G+++ ++ G V+ C Y ++G++ TC +G W + P C
Sbjct: 2270 IQNGFMKGE--NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPP 2327
Query: 323 ----------------VATHQLKR------------------------CKIAGVNIKTLL 342
V T K CKI L+
Sbjct: 2328 LLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLI 2387
Query: 343 K----LSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWN-PEVDCTEKREQFCPPPP 393
+ + S ++Y C F R + +G W+ P +C CP P
Sbjct: 2388 SFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVE---CPQPE 2444
Query: 394 QIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRCVESTAYCGP 451
+IPN + Y CK + L +C ++G W P C C
Sbjct: 2445 EIPNGIIDVQGLAYLS--TALYTCKPGFELVGNTTTLCGENGHWLGGKPTC--KAIECLK 2500
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS-EPPRC 503
P I NG F + G TVTY C ++L+G +TC W + P C
Sbjct: 2501 PKEILNG---KFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSC 2551
Score = 51.6 bits (122), Expect = 2e-06
Identities = 40/138 (28%), Positives = 63/138 (45%), Gaps = 13/138 (9%)
Query: 383 EKREQFCPPPPQIPNA--QNMTTTVNYQDGEKVAVLCKENY-LLPEAKEIVCKDGRW-QS 438
+ + FC P++ + T + + + G KV + C + L+ + G+W Q
Sbjct: 1622 DSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQP 1681
Query: 439 LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQW 497
LP C + CG PP + NG ++ + GSTVTY+C + Y L G + C N W
Sbjct: 1682 LPHCERIS--CGVPPPLENGFHSA---DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSW 1736
Query: 498 S-EPPRCL--DPCVVSEE 512
+ P CL D C V +
Sbjct: 1737 NGVSPSCLDVDECAVGSD 1754
Score = 42.7 bits (99), Expect = 9e-04
Identities = 46/165 (27%), Positives = 63/165 (38%), Gaps = 13/165 (7%)
Query: 47 TGEVFYYSCE--YNFVSPSKSFWTRITCTEEG-WS-PTPKCL-RMCSFPFVKNGHSESSG 101
TG YSC Y+ PS++ CTE G WS P P C C PFV ++ S
Sbjct: 3317 TGPNVVYSCNRGYSLEGPSEAH-----CTENGTWSHPVPLCKPNPCPVPFVIPENALLSE 3371
Query: 102 LIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPK 161
V I C G+ LQ + + W T K C P N A +
Sbjct: 3372 KEFYVDQNVSIKCREGFLLQGHGIITCNPDETW-TQTSAKCEKISCGPPAHVENAIA--R 3428
Query: 162 KESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVR 206
Y+ GD++ +SC + G C + G + P C+ R
Sbjct: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCR 3473
Score = 42.7 bits (99), Expect = 9e-04
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 70 ITCT-EEGWSPTP-KCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNI 127
ITC +E W+ T KC ++ P ++ + G+ + GD + C +GY L+ +++
Sbjct: 3396 ITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSV 3455
Query: 128 SCVERG-WSTPPICSFTKGECHVPILEANVDAQP 160
C+E G W++PPIC + C P + +P
Sbjct: 3456 -CLENGTWTSPPIC---RAVCRFPCQNGGICQRP 3485
Score = 37.7 bits (86), Expect = 0.029
Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 237 CNPNFIINGPKKIQCV-DGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEV 295
C+P F + G I C+ +G W+ + +V+TC ++ + ++G++ S + + V
Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYC-RVRTCPHLRQPKHGHISCSTREMLYKTTCLV 464
Query: 296 NCRNEYAMIGNNMITCI-NGIWT-ELPMCVATH 326
C Y + G++ +TC N W P CV H
Sbjct: 465 ACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERH 497
Score = 36.6 bits (83), Expect = 0.064
Identities = 41/205 (20%), Positives = 80/205 (39%), Gaps = 25/205 (12%)
Query: 246 PKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIG 305
P+ C +G + TC ++ C + E GY + + V C + ++G
Sbjct: 357 PEDCVCREGYRASGQTC--ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVG 414
Query: 306 NNMITCI-NGIWT------ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYR 358
+++I C+ NG+W+ + C Q K I+ S +E + +
Sbjct: 415 SSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHIS---------CSTREMLYKTTCLVA 465
Query: 359 CSDIFRYRHSVCI----NGKWN-PEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKV 413
C + +R S + N +W+ PE C E+ P + + + + G
Sbjct: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
Query: 414 AVLCKENYLLPEAKEIV--CKDGRW 436
V C++ ++L KE++ G+W
Sbjct: 526 YVSCRQGFILSGVKEMLRCTTSGKW 550
Score = 35.4 bits (80), Expect = 0.14
Identities = 35/133 (26%), Positives = 54/133 (40%), Gaps = 11/133 (8%)
Query: 70 ITCTEEG-WSPTPKCLRMCSFPFV---KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEK 125
I C G WS + R+ + P + K+GH S L T + C+ GY L+ ++K
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477
Query: 126 NISCVERGWSTP-PICSFTKGECHVPILEANVDAQPK---KESYKVGDVLKFSCRKNLIR 181
W P P C + C + +V P K+ K G + SCR+ I
Sbjct: 478 LTCQGNSQWDGPEPRC--VERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFIL 535
Query: 182 VG-SDSVQCYQFG 193
G + ++C G
Sbjct: 536 SGVKEMLRCTTSG 548
Score = 34.3 bits (77), Expect = 0.32
Identities = 26/73 (35%), Positives = 36/73 (49%), Gaps = 4/73 (5%)
Query: 472 STVTYRCQSFYKLQGSVTVTCR-NKQWSEP-PRCLDPCVVSEENMNKNNIQLKWRNDGKL 529
+T C Y+L+GS +TC+ N QW P PRC++ S M K+ I + N GK
Sbjct: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER-HCSTFQMPKDVI-ISPHNCGKQ 517
Query: 530 YAKTGDAVEFQCK 542
AK G C+
Sbjct: 518 PAKFGTICYVSCR 530
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 123 bits (308), Expect = 5e-28
Identities = 130/508 (25%), Positives = 200/508 (39%), Gaps = 77/508 (15%)
Query: 48 GEVFYYSCEYNFV---SPSKSFWTRITCTEEGWSPT-PKCLRMCSF------PFVKNG-- 95
G YSC F SPS TC G + T K +C P + NG
Sbjct: 1927 GSTVNYSCNEGFRLIGSPST------TCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1980
Query: 96 HSESSGLIHLEGDTVQIICNTGYSLQN-----NEKNISCVERG-----WSTPPICSFTKG 145
+S + H G V C+TG + E++I C + WS+PP +
Sbjct: 1981 YSNNRTSFH-NGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTN 2039
Query: 146 ECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQ 204
+C P +E + + + + ++++F C+ + VGS +VQC G W P P C
Sbjct: 2040 KCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS-- 2097
Query: 205 VRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTT-LPTC 262
R C PPP++ +GE ++ + + V Y C P++ + G + C G+W+ P C
Sbjct: 2098 -RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 2156
Query: 263 VEQVKTCG-YIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI----NGIW- 316
VK+C ++ +L +G V + Q G V C + + G + C+ +W
Sbjct: 2157 T--VKSCDDFLGQLPHGRVLLPLN-LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 2213
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLL--KLSGKEFN---HNSRIRYRCS----------- 360
+ +P+C +I N +L + +G F + I Y C
Sbjct: 2214 SSVPVCE--------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNL 2265
Query: 361 ---DIFRYRHSVCINGKWN-PEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAV 415
R NG W+ P C CP PP+I N + V+ Y G ++
Sbjct: 2266 IGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISY 2325
Query: 416 LCKENYLLPEAKEIVCKD-GRWQSLPR-CVESTAYCGPPPSINNGDTTSFPLSVYPPGST 473
+C YLL I C D G W L C E C P +N VY G
Sbjct: 2326 ICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVN--CSFPLFMNGISKELEMKKVYHYGDY 2383
Query: 474 VTYRCQSFYKLQGSVTVTCRNKQWSEPP 501
VT +C+ Y L+GS C+ +PP
Sbjct: 2384 VTLKCEDGYTLEGSPWSQCQADDRWDPP 2411
Score = 108 bits (270), Expect = 1e-23
Identities = 134/522 (25%), Positives = 207/522 (39%), Gaps = 84/522 (16%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGL 102
S P G Y C + S ITC + +PK +C K +G+
Sbjct: 1411 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1464
Query: 103 IHL-----EGDTVQIICNTGYSLQNNEKNISCVERG----WST-PPICSFTKGECHVPIL 152
+H+ G + C TG+ L + + C+ G WST PPIC + C +P
Sbjct: 1465 VHVITDIQVGSRINYSCTTGHRLIGHS-SAECILSGNTAHWSTKPPICQ--RIPCGLPPT 1521
Query: 153 EANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-WSPNFPT 200
AN D +E++ G V+ + C RK VG S+ C Q G WS P
Sbjct: 1522 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1581
Query: 201 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TT 258
C + + PP + NG + + + NEVVE+ C P F++ GP++++C +W
Sbjct: 1582 CI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1639
Query: 259 LPTCVEQVKTCGYIPELEYGYVQPS-VPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIW 316
LP+C + C PE+ +G PS + G V +C Y + G + C G W
Sbjct: 1640 LPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDW 1696
Query: 317 T-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS------- 368
+ E P C +K C + L +++ + C + FR + S
Sbjct: 1697 SPEAPRCA----VKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL 1752
Query: 369 VCINGKWNPEVDCTEKREQFCPPPPQIPNAQNM-TTTVNYQDGEKVAVLCKEN------Y 421
V + WN V E FCP PP I N ++ T + + G++++ C + +
Sbjct: 1753 VGMRSLWNNSVPVCE--HIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF 1810
Query: 422 LLPEAKEIVCK-----DGRWQS-LPRCVES--TAYCGPPPSINNGDTTSFPLS--VYPPG 471
L I C +G W S PRC S +C P T P++ +P G
Sbjct: 1811 NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT-IPINDFEFPVG 1869
Query: 472 STVTYRCQSFY------------KLQGSVTVTCRNKQWSEPP 501
+++ Y C+ Y + SV CR K PP
Sbjct: 1870 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPP 1911
Score = 99.8 bits (247), Expect = 6e-21
Identities = 128/506 (25%), Positives = 199/506 (39%), Gaps = 69/506 (13%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGL 102
S P G Y C + S ITC + +PK +C K +G+
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564
Query: 103 IHL-----EGDTVQIICNTGYSLQNNEKNISCVERG----WST-PPICSFTKGECHVPIL 152
+H+ G + C TG+ L + + C+ G WST PPIC + C +P
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGHS-SAECILSGNAAHWSTKPPICQ--RIPCGLPPT 621
Query: 153 EANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-WSPNFPT 200
AN D +E++ G V+ + C RK VG S+ C Q G WS P
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 201 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TT 258
C + + PP + NG + + + NEVVE+ C P F++ GP++++C +W
Sbjct: 682 CI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 739
Query: 259 LPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIW 316
LP+C + C P+ L Q + G V +C Y + G + C G W
Sbjct: 740 LPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 796
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---HSVCI-- 371
+ T ++K C + L +++ + C + F+ + S C+
Sbjct: 797 SP---AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 853
Query: 372 --NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK------ENYL 422
WN V E + FCP PP IPN ++ + + G+ V C ++
Sbjct: 854 GMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFD 911
Query: 423 LPEAKEIVCK-----DGRWQS-LPRCVESTAYCGPPPSINNGD-TTSFPLSVYPPGSTVT 475
L I C +G W S PRC +C P T S +P G+++
Sbjct: 912 LIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 476 YRCQSFYKLQGSVTVTC-RNKQWSEP 500
Y C+ Y ++TC N WS P
Sbjct: 971 YECRPEY-YGRPFSITCLDNLVWSSP 995
Score = 99.8 bits (247), Expect = 6e-21
Identities = 128/506 (25%), Positives = 199/506 (39%), Gaps = 69/506 (13%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGL 102
S P G Y C + S ITC + +PK +C K +G+
Sbjct: 961 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014
Query: 103 IHL-----EGDTVQIICNTGYSLQNNEKNISCVERG----WST-PPICSFTKGECHVPIL 152
+H+ G + C TG+ L + + C+ G WST PPIC + C +P
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGHS-SAECILSGNAAHWSTKPPICQ--RIPCGLPPT 1071
Query: 153 EANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-WSPNFPT 200
AN D +E++ G V+ + C RK VG S+ C Q G WS P
Sbjct: 1072 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131
Query: 201 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TT 258
C + + PP + NG + + + NEVVE+ C P F++ GP++++C +W
Sbjct: 1132 CI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1189
Query: 259 LPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIW 316
LP+C + C P+ L Q + G V +C Y + G + C G W
Sbjct: 1190 LPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 1246
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---HSVCI-- 371
+ T ++K C + L +++ + C + F+ + S C+
Sbjct: 1247 SP---AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 1303
Query: 372 --NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK------ENYL 422
WN V E + FCP PP IPN ++ + + G+ V C ++
Sbjct: 1304 GMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 1361
Query: 423 LPEAKEIVCK-----DGRWQS-LPRCVESTAYCGPPPSINNGD-TTSFPLSVYPPGSTVT 475
L I C +G W S PRC +C P T S +P G+++
Sbjct: 1362 LIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 1420
Query: 476 YRCQSFYKLQGSVTVTC-RNKQWSEP 500
Y C+ Y ++TC N WS P
Sbjct: 1421 YECRPEY-YGRPFSITCLDNLVWSSP 1445
Score = 99.8 bits (247), Expect = 6e-21
Identities = 127/503 (25%), Positives = 195/503 (38%), Gaps = 86/503 (17%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRI--TCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHL 105
G++F SC N V W+ + C + P P+ PF +G++H+
Sbjct: 1882 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--------NGMVHI 1920
Query: 106 E-----GDTVQIICNTGYSLQNNEKNISCVERG----WSTP-PICSFTKGECHVPILEAN 155
G TV CN G+ L + +C+ G W PIC C P +N
Sbjct: 1921 NTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEIIS--CEPPPTISN 1977
Query: 156 VDAQPK-KESYKVGDVLKFSCRKN------LIRVGSDSVQCY----QFG-WSPNFPTCKG 203
D + S+ G V+ + C VG S+ C Q G WS P C
Sbjct: 1978 GDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 2037
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TTLPT 261
+ P ++ N + + E++ + C P F++ G +QC +G W LP
Sbjct: 2038 TNKCTAP--EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPH 2095
Query: 262 CVEQVKTCGYIPELEYG-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-E 318
C + C PE+ +G + + G V +C Y + G + C G W+ E
Sbjct: 2096 CS---RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPE 2152
Query: 319 LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR-----HSVCING 373
P C +K C + L +++ + C + FR + H V
Sbjct: 2153 APRCT----VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 2208
Query: 374 K--WNPEVDCTEKREQFCPPPPQIPNAQNMTTTV-NYQDGEKVAVLCKEN------YLLP 424
K WN V E + FCP PP I N ++ T + G++++ C + + L
Sbjct: 2209 KALWNSSVPVCE--QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLI 2266
Query: 425 EAKEIVCK-----DGRWQS-LPRCVEST-AYCGPPPSINNGDTTSFPLSVYPPGSTVTYR 477
I C +G W S PRC S A C PP I NG +S+Y PG T++Y
Sbjct: 2267 GESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYI 2326
Query: 478 CQSFYKLQGSVTVTCRNKQ-WSE 499
C Y L G + C ++ WS+
Sbjct: 2327 CDPGYLLVGKGFIFCTDQGIWSQ 2349
Score = 95.1 bits (235), Expect = 2e-19
Identities = 125/534 (23%), Positives = 217/534 (40%), Gaps = 84/534 (15%)
Query: 26 PKIHHGFLYDEEDYNPFSQ--VPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TP 81
P+I HG ++ P Q G+ +YSCE + + + CT +G WSP P
Sbjct: 1651 PEILHG------EHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAP 1701
Query: 82 KC-LRMCSFPFVKNGHSESSGLIHLE-GDTVQIICNTGYSLQNNEKNISCVERG----WS 135
+C ++ C + H ++L+ G V +C+ G+ L+ + + CV G W+
Sbjct: 1702 RCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWN 1760
Query: 136 TP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIR------VGSDSVQ 188
P+C IL P + G + ++C + R +G +++
Sbjct: 1761 NSVPVCEHIFCPNPPAILNGRHTGTPSGD-IPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
Query: 189 CYQFG-----WSPNFPTCKGQVRS--CGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPN 240
C WS P C+ VR+ C P Q I E+ + Y+C P
Sbjct: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPG 1879
Query: 241 FIINGPKKIQCVDG-EWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRN 299
+ I C++ W+++ + K+CG PE G V + Q G +V +C
Sbjct: 1880 YF-GKMFSISCLENLVWSSVEDNCRR-KSCGPPPEPFNGMVHINTDT-QFGSTVNYSCNE 1936
Query: 300 EYAMIGNNMITCI----NGIWTE-LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSR 354
+ +IG+ TC+ N W + P+C ++ + +S +F N+R
Sbjct: 1937 GFRLIGSPSTTCLVSGNNVTWDKKAPICEI-----------ISCEPPPTISNGDFYSNNR 1985
Query: 355 IRYRCSDIFRYRHSVCINGKWNPE------VDCTEKREQF----CPPP----------PQ 394
+ + Y+ +G+ E + CT K +Q PPP P+
Sbjct: 1986 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 2045
Query: 395 IPNAQNMTTTVNYQD-GEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCGP 451
+ NA + ++ E + C+ +++ + + C+ +GRW LP C + C P
Sbjct: 2046 VENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC---SRVCQP 2102
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWS-EPPRC 503
PP I +G+ T + PG V Y C+ Y L+G+ ++ C + WS E PRC
Sbjct: 2103 PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 2156
Score = 87.0 bits (214), Expect = 4e-17
Identities = 121/512 (23%), Positives = 195/512 (38%), Gaps = 83/512 (16%)
Query: 44 QVPTGEVFYYSCE-------YNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGH 96
+ P G Y C ++ + S WT +C R +N
Sbjct: 62 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWT---------GAKDRCRRKSC----RNPP 108
Query: 97 SESSGLIHLE-----GDTVQIICNTGYSLQNNEKNISCVERG----WSTP-PICSFTKGE 146
+G++H+ G ++ C GY L + + +C+ G W PIC +
Sbjct: 109 DPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSS-SATCIISGDTVIWDNETPICD--RIP 165
Query: 147 CHVPILEANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-W 194
C +P N D +E++ G V+ + C RK VG S+ C Q G W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VD 253
S P C + + PP + NG + + + NEVVE+ C P F++ GP++++C
Sbjct: 226 SGPAPQCI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 283
Query: 254 GEW-TTLPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC 311
+W LP+C + C P+ L Q + G V +C Y + G + C
Sbjct: 284 NKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 340
Query: 312 I-NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---H 367
G W+ T ++K C + L +++ + C + F+ +
Sbjct: 341 TPQGDWSP---AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSA 397
Query: 368 SVCI----NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK---- 418
S C+ WN V E + FCP PP IPN ++ + + G+ V C
Sbjct: 398 SYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
Query: 419 --ENYLLPEAKEIVCK-----DGRWQS-LPRCVESTAYCGPPPSINNGD-TTSFPLSVYP 469
++ L I C +G W S PRC +C P T S +P
Sbjct: 456 RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFP 514
Query: 470 PGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP 500
G+++ Y C+ Y ++TC N WS P
Sbjct: 515 IGTSLKYECRPEY-YGRPFSITCLDNLVWSSP 545
Score = 47.4 bits (111), Expect = 4e-05
Identities = 49/185 (26%), Positives = 73/185 (39%), Gaps = 32/185 (17%)
Query: 41 PFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCTEEG-----W-SPTPKC--- 83
PF +P G+ Y+C+ +N + S I CT + W SP P+C
Sbjct: 2239 PFGDIPYGKEISYACDTHPDRGMTFNLIGESS-----IRCTSDPQGNGVWSSPAPRCELS 2293
Query: 84 -LRMCSF-PFVKNGHSESSGL-IHLEGDTVQIICNTGYSLQNNEKNISCVERG-WS-TPP 138
C P ++NGH + ++L G T+ IC+ GY L + I C ++G WS
Sbjct: 2294 VPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLV-GKGFIFCTDQGIWSQLDH 2352
Query: 139 ICSFTKGECHVPILEANVDAQ-PKKESYKVGDVLKFSCRKNLIRVGSDSVQCY-QFGWSP 196
C + C P+ + + K+ Y GD + C GS QC W P
Sbjct: 2353 YCK--EVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 2410
Query: 197 NFPTC 201
C
Sbjct: 2411 PLAKC 2415
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 123 bits (308), Expect = 5e-28
Identities = 130/508 (25%), Positives = 200/508 (39%), Gaps = 77/508 (15%)
Query: 48 GEVFYYSCEYNFV---SPSKSFWTRITCTEEGWSPT-PKCLRMCSF------PFVKNG-- 95
G YSC F SPS TC G + T K +C P + NG
Sbjct: 1477 GSTVNYSCNEGFRLIGSPST------TCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF 1530
Query: 96 HSESSGLIHLEGDTVQIICNTGYSLQN-----NEKNISCVERG-----WSTPPICSFTKG 145
+S + H G V C+TG + E++I C + WS+PP +
Sbjct: 1531 YSNNRTSFH-NGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTN 1589
Query: 146 ECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQ 204
+C P +E + + + + ++++F C+ + VGS +VQC G W P P C
Sbjct: 1590 KCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCS-- 1647
Query: 205 VRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTT-LPTC 262
R C PPP++ +GE ++ + + V Y C P++ + G + C G+W+ P C
Sbjct: 1648 -RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 1706
Query: 263 VEQVKTCG-YIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI----NGIW- 316
VK+C ++ +L +G V + Q G V C + + G + C+ +W
Sbjct: 1707 T--VKSCDDFLGQLPHGRVLLPLN-LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWN 1763
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLL--KLSGKEFN---HNSRIRYRCS----------- 360
+ +P+C +I N +L + +G F + I Y C
Sbjct: 1764 SSVPVCE--------QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNL 1815
Query: 361 ---DIFRYRHSVCINGKWN-PEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAV 415
R NG W+ P C CP PP+I N + V+ Y G ++
Sbjct: 1816 IGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISY 1875
Query: 416 LCKENYLLPEAKEIVCKD-GRWQSLPR-CVESTAYCGPPPSINNGDTTSFPLSVYPPGST 473
+C YLL I C D G W L C E C P +N VY G
Sbjct: 1876 ICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVN--CSFPLFMNGISKELEMKKVYHYGDY 1933
Query: 474 VTYRCQSFYKLQGSVTVTCRNKQWSEPP 501
VT +C+ Y L+GS C+ +PP
Sbjct: 1934 VTLKCEDGYTLEGSPWSQCQADDRWDPP 1961
Score = 108 bits (270), Expect = 1e-23
Identities = 134/522 (25%), Positives = 207/522 (39%), Gaps = 84/522 (16%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGL 102
S P G Y C + S ITC + +PK +C K +G+
Sbjct: 961 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014
Query: 103 IHL-----EGDTVQIICNTGYSLQNNEKNISCVERG----WST-PPICSFTKGECHVPIL 152
+H+ G + C TG+ L + + C+ G WST PPIC + C +P
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGHS-SAECILSGNTAHWSTKPPICQ--RIPCGLPPT 1071
Query: 153 EANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-WSPNFPT 200
AN D +E++ G V+ + C RK VG S+ C Q G WS P
Sbjct: 1072 IANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 1131
Query: 201 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TT 258
C + + PP + NG + + + NEVVE+ C P F++ GP++++C +W
Sbjct: 1132 CI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 1189
Query: 259 LPTCVEQVKTCGYIPELEYGYVQPS-VPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIW 316
LP+C + C PE+ +G PS + G V +C Y + G + C G W
Sbjct: 1190 LPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDW 1246
Query: 317 T-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS------- 368
+ E P C +K C + L +++ + C + FR + S
Sbjct: 1247 SPEAPRCA----VKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVL 1302
Query: 369 VCINGKWNPEVDCTEKREQFCPPPPQIPNAQNM-TTTVNYQDGEKVAVLCKEN------Y 421
V + WN V E FCP PP I N ++ T + + G++++ C + +
Sbjct: 1303 VGMRSLWNNSVPVCE--HIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTF 1360
Query: 422 LLPEAKEIVCK-----DGRWQS-LPRCVES--TAYCGPPPSINNGDTTSFPLS--VYPPG 471
L I C +G W S PRC S +C P T P++ +P G
Sbjct: 1361 NLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT-IPINDFEFPVG 1419
Query: 472 STVTYRCQSFY------------KLQGSVTVTCRNKQWSEPP 501
+++ Y C+ Y + SV CR K PP
Sbjct: 1420 TSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPP 1461
Score = 99.8 bits (247), Expect = 6e-21
Identities = 128/506 (25%), Positives = 199/506 (39%), Gaps = 69/506 (13%)
Query: 43 SQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGL 102
S P G Y C + S ITC + +PK +C K +G+
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564
Query: 103 IHL-----EGDTVQIICNTGYSLQNNEKNISCVERG----WST-PPICSFTKGECHVPIL 152
+H+ G + C TG+ L + + C+ G WST PPIC + C +P
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGHS-SAECILSGNAAHWSTKPPICQ--RIPCGLPPT 621
Query: 153 EANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-WSPNFPT 200
AN D +E++ G V+ + C RK VG S+ C Q G WS P
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 201 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TT 258
C + + PP + NG + + + NEVVE+ C P F++ GP++++C +W
Sbjct: 682 CI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPE 739
Query: 259 LPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIW 316
LP+C + C P+ L Q + G V +C Y + G + C G W
Sbjct: 740 LPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDW 796
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---HSVCI-- 371
+ T ++K C + L +++ + C + F+ + S C+
Sbjct: 797 SP---AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLA 853
Query: 372 --NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK------ENYL 422
WN V E + FCP PP IPN ++ + + G+ V C ++
Sbjct: 854 GMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFD 911
Query: 423 LPEAKEIVCK-----DGRWQS-LPRCVESTAYCGPPPSINNGD-TTSFPLSVYPPGSTVT 475
L I C +G W S PRC +C P T S +P G+++
Sbjct: 912 LIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFPIGTSLK 970
Query: 476 YRCQSFYKLQGSVTVTC-RNKQWSEP 500
Y C+ Y ++TC N WS P
Sbjct: 971 YECRPEY-YGRPFSITCLDNLVWSSP 995
Score = 99.8 bits (247), Expect = 6e-21
Identities = 127/503 (25%), Positives = 195/503 (38%), Gaps = 86/503 (17%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRI--TCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHL 105
G++F SC N V W+ + C + P P+ PF +G++H+
Sbjct: 1432 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--------NGMVHI 1470
Query: 106 E-----GDTVQIICNTGYSLQNNEKNISCVERG----WSTP-PICSFTKGECHVPILEAN 155
G TV CN G+ L + +C+ G W PIC C P +N
Sbjct: 1471 NTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEIIS--CEPPPTISN 1527
Query: 156 VDAQPK-KESYKVGDVLKFSCRKN------LIRVGSDSVQCY----QFG-WSPNFPTCKG 203
D + S+ G V+ + C VG S+ C Q G WS P C
Sbjct: 1528 GDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCIS 1587
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW-TTLPT 261
+ P ++ N + + E++ + C P F++ G +QC +G W LP
Sbjct: 1588 TNKCTAP--EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPH 1645
Query: 262 CVEQVKTCGYIPELEYG-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-E 318
C + C PE+ +G + + G V +C Y + G + C G W+ E
Sbjct: 1646 CS---RVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPE 1702
Query: 319 LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR-----HSVCING 373
P C +K C + L +++ + C + FR + H V
Sbjct: 1703 APRCT----VKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGM 1758
Query: 374 K--WNPEVDCTEKREQFCPPPPQIPNAQNMTTTV-NYQDGEKVAVLCKEN------YLLP 424
K WN V E + FCP PP I N ++ T + G++++ C + + L
Sbjct: 1759 KALWNSSVPVCE--QIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLI 1816
Query: 425 EAKEIVCK-----DGRWQS-LPRCVEST-AYCGPPPSINNGDTTSFPLSVYPPGSTVTYR 477
I C +G W S PRC S A C PP I NG +S+Y PG T++Y
Sbjct: 1817 GESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYI 1876
Query: 478 CQSFYKLQGSVTVTCRNKQ-WSE 499
C Y L G + C ++ WS+
Sbjct: 1877 CDPGYLLVGKGFIFCTDQGIWSQ 1899
Score = 95.1 bits (235), Expect = 2e-19
Identities = 125/534 (23%), Positives = 217/534 (40%), Gaps = 84/534 (15%)
Query: 26 PKIHHGFLYDEEDYNPFSQ--VPTGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSP-TP 81
P+I HG ++ P Q G+ +YSCE + + + CT +G WSP P
Sbjct: 1201 PEILHG------EHTPSHQDNFSPGQEVFYSCEPGYDLRGAA---SLHCTPQGDWSPEAP 1251
Query: 82 KC-LRMCSFPFVKNGHSESSGLIHLE-GDTVQIICNTGYSLQNNEKNISCVERG----WS 135
+C ++ C + H ++L+ G V +C+ G+ L+ + + CV G W+
Sbjct: 1252 RCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVS-HCVLVGMRSLWN 1310
Query: 136 TP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIR------VGSDSVQ 188
P+C IL P + G + ++C + R +G +++
Sbjct: 1311 NSVPVCEHIFCPNPPAILNGRHTGTPSGD-IPYGKEISYTCDPHPDRGMTFNLIGESTIR 1369
Query: 189 CYQFG-----WSPNFPTCKGQVRS--CGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPN 240
C WS P C+ VR+ C P Q I E+ + Y+C P
Sbjct: 1370 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPG 1429
Query: 241 FIINGPKKIQCVDG-EWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRN 299
+ I C++ W+++ + K+CG PE G V + Q G +V +C
Sbjct: 1430 YF-GKMFSISCLENLVWSSVEDNCRR-KSCGPPPEPFNGMVHINTDT-QFGSTVNYSCNE 1486
Query: 300 EYAMIGNNMITCI----NGIWTE-LPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSR 354
+ +IG+ TC+ N W + P+C ++ + +S +F N+R
Sbjct: 1487 GFRLIGSPSTTCLVSGNNVTWDKKAPICEI-----------ISCEPPPTISNGDFYSNNR 1535
Query: 355 IRYRCSDIFRYRHSVCINGKWNPE------VDCTEKREQF----CPPP----------PQ 394
+ + Y+ +G+ E + CT K +Q PPP P+
Sbjct: 1536 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 1595
Query: 395 IPNAQNMTTTVNYQD-GEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCGP 451
+ NA + ++ E + C+ +++ + + C+ +GRW LP C + C P
Sbjct: 1596 VENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHC---SRVCQP 1652
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWS-EPPRC 503
PP I +G+ T + PG V Y C+ Y L+G+ ++ C + WS E PRC
Sbjct: 1653 PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC 1706
Score = 87.0 bits (214), Expect = 4e-17
Identities = 121/512 (23%), Positives = 195/512 (38%), Gaps = 83/512 (16%)
Query: 44 QVPTGEVFYYSCE-------YNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGH 96
+ P G Y C ++ + S WT +C R +N
Sbjct: 62 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWT---------GAKDRCRRKSC----RNPP 108
Query: 97 SESSGLIHLE-----GDTVQIICNTGYSLQNNEKNISCVERG----WSTP-PICSFTKGE 146
+G++H+ G ++ C GY L + + +C+ G W PIC +
Sbjct: 109 DPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSS-SATCIISGDTVIWDNETPICD--RIP 165
Query: 147 CHVPILEANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-W 194
C +P N D +E++ G V+ + C RK VG S+ C Q G W
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VD 253
S P C + + PP + NG + + + NEVVE+ C P F++ GP++++C
Sbjct: 226 SGPAPQCI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 283
Query: 254 GEW-TTLPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC 311
+W LP+C + C P+ L Q + G V +C Y + G + C
Sbjct: 284 NKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 340
Query: 312 I-NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---H 367
G W+ T ++K C + L +++ + C + F+ +
Sbjct: 341 TPQGDWSP---AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSA 397
Query: 368 SVCI----NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK---- 418
S C+ WN V E + FCP PP IPN ++ + + G+ V C
Sbjct: 398 SYCVLAGMESLWNSSVPVCE--QIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPD 455
Query: 419 --ENYLLPEAKEIVCK-----DGRWQS-LPRCVESTAYCGPPPSINNGD-TTSFPLSVYP 469
++ L I C +G W S PRC +C P T S +P
Sbjct: 456 RGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQAPDHFLFAKLKTQTNASDFP 514
Query: 470 PGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP 500
G+++ Y C+ Y ++TC N WS P
Sbjct: 515 IGTSLKYECRPEY-YGRPFSITCLDNLVWSSP 545
Score = 47.4 bits (111), Expect = 4e-05
Identities = 49/185 (26%), Positives = 73/185 (39%), Gaps = 32/185 (17%)
Query: 41 PFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCTEEG-----W-SPTPKC--- 83
PF +P G+ Y+C+ +N + S I CT + W SP P+C
Sbjct: 1789 PFGDIPYGKEISYACDTHPDRGMTFNLIGESS-----IRCTSDPQGNGVWSSPAPRCELS 1843
Query: 84 -LRMCSF-PFVKNGHSESSGL-IHLEGDTVQIICNTGYSLQNNEKNISCVERG-WS-TPP 138
C P ++NGH + ++L G T+ IC+ GY L + I C ++G WS
Sbjct: 1844 VPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLV-GKGFIFCTDQGIWSQLDH 1902
Query: 139 ICSFTKGECHVPILEANVDAQ-PKKESYKVGDVLKFSCRKNLIRVGSDSVQCY-QFGWSP 196
C + C P+ + + K+ Y GD + C GS QC W P
Sbjct: 1903 YCK--EVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 1960
Query: 197 NFPTC 201
C
Sbjct: 1961 PLAKC 1965
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 122 bits (306), Expect = 9e-28
Identities = 50/124 (40%), Positives = 78/124 (62%), Gaps = 3/124 (2%)
Query: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
CD+P I HG LY E P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
Query: 83 CLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPIC-- 140
CLR C FP+++NG++++ G ++G ++ + C+ GY+L + ++C+E GWS P C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
Query: 141 -SFT 143
SFT
Sbjct: 445 VSFT 448
Score = 100 bits (250), Expect = 3e-21
Identities = 103/429 (24%), Positives = 145/429 (33%), Gaps = 59/429 (13%)
Query: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGW---SPTPKCL-RMCSFPFVK--NGHSES 99
P G Y C + S + C + W +P KC R C P + +
Sbjct: 43 PEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
Query: 100 SGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP-PICSFTKGECHVPILEAN--- 155
G + G CN GY L C GW+ PIC K C N
Sbjct: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPENGKI 157
Query: 156 -VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQ 213
A Y G ++F C G + + C G WS P C SC P
Sbjct: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI--SCKSPDV 215
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIP 273
++ + + K Y NE +Y CN + + C + W LP+C E+ YIP
Sbjct: 216 INGSPISQ--KIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIP 273
Query: 274 ELEYGYVQPSVPPYQHGVSVEVNCRNE-YAMIGNNMITCINGIWTELPMCVATHQLKRCK 332
+Y P ++ G + CRN Y N C + W P C LK C
Sbjct: 274 NGDY---SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCT----LKPCD 326
Query: 333 IAGVNIKTLLKLSGKEFNHNSR-----------IRYRCSDIFR------YRHSVCINGKW 375
+ G ++ N R Y C + F + H C W
Sbjct: 327 YPDIK-------HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGW 379
Query: 376 NPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK-EIVCKDG 434
+P V C K P + N N + G+ + V C Y LP+A+ + C +
Sbjct: 380 SPAVPCLRKCYF-----PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMEN 434
Query: 435 RWQSLPRCV 443
W PRC+
Sbjct: 435 GWSPTPRCI 443
Score = 88.6 bits (218), Expect = 1e-17
Identities = 70/284 (24%), Positives = 117/284 (41%), Gaps = 19/284 (6%)
Query: 235 YDCNPNFIINGPKKIQCVDGEWTTL-PTCVEQVKTCGYIPELEYG-YVQPSVPPYQHGVS 292
Y C P + G + C GEW L P Q + CG+ + +G + +++GV
Sbjct: 50 YKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVK 109
Query: 293 VEVNCRNEYAMIGN-NMITCINGIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN 350
C Y ++G N C WT ++P+C L I + +E++
Sbjct: 110 AVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH 169
Query: 351 HNSRIRYRCSDIFRYRHSVCIN----GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN 406
+R+ C+ ++ ++ G W+ E K + P + N ++ +
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE---KPKCVEISCKSPDVINGSPISQKII 226
Query: 407 YQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS 466
Y++ E+ C Y E + VC + W+ LP C E + P I NGD + PL
Sbjct: 227 YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC---DNPYIPNGDYS--PLR 281
Query: 467 V-YPPGSTVTYRCQS-FYKLQGSVTVTCRNKQWSEPPRC-LDPC 507
+ + G +TY+C++ FY T C + W PRC L PC
Sbjct: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPC 325
Score = 80.9 bits (198), Expect = 3e-15
Identities = 93/379 (24%), Positives = 139/379 (36%), Gaps = 39/379 (10%)
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEI 222
++Y G + CR +G+ + C + W P K Q R CG P G
Sbjct: 40 QTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
Query: 223 RKEEYGHNEVVEYDCNPNFIINGPKKI-QCVDGEWTT-LPTCVEQVKTCGYIPELEYGYV 280
+ + Y CN + + G +C WT +P C +V C + E G +
Sbjct: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC--EVVKCLPVTAPENGKI 157
Query: 281 QPSV----PPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLKRCKIA 334
S Y G +V C + Y + G+ + C +G W+ E P CV I
Sbjct: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVIN 217
Query: 335 GVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH---SVCINGKWNPEVDCTEKREQFCPP 391
G I K+ KE N R +Y+C+ + Y +VC W P C EK C
Sbjct: 218 GSPISQ--KIIYKE---NERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS---C-D 268
Query: 392 PPQIPNAQNMTTTVNYQDGEKVAVLCKEN-YLLPEAKEIVCKDGRWQSLPRCVESTAYCG 450
P IPN + ++ G+++ C+ Y C W PRC + C
Sbjct: 269 NPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCD 326
Query: 451 PPPSINNG------DTTSFPLSVYPPGSTVTYRCQSFYKL-QGSV--TVTCRNKQWSEPP 501
P + G FP++V G +Y C ++ GS + C WS
Sbjct: 327 YPDIKHGGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAV 383
Query: 502 RCLDPCVVS--EENMNKNN 518
CL C E N+N+
Sbjct: 384 PCLRKCYFPYLENGYNQNH 402
Score = 68.9 bits (167), Expect = 1e-11
Identities = 83/359 (23%), Positives = 130/359 (36%), Gaps = 38/359 (10%)
Query: 165 YKVGDVLKFSCRKNLIRVGSDSV-QCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIR 223
++ G ++C + +G + +C GW+ + P C +V C P NG++
Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC--EVVKCLPVTAPENGKIVSSA 161
Query: 224 KE---EYGHNEVVEYDCNPNFIINGPKKIQCVD-GEWTT-LPTCVEQVKTCGYIPELEYG 278
E EY + V + CN + I G +++ C D G W+ P CVE +C P++ G
Sbjct: 162 MEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI--SCKS-PDVING 218
Query: 279 YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNI 338
Y+ + C Y C W LP C + K C +
Sbjct: 219 SPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC----EEKSCDNPYIPN 274
Query: 339 KTLLKLSGKEFNHNSRIRYRCSDIF----RYRHSVCINGKWNPEVDCTEKREQFCPPPPQ 394
L K I Y+C + F R + C + W P CT K + P
Sbjct: 275 GDYSPLRIKH-RTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDY----PD 329
Query: 395 IPNA----QNMTTTV-NYQDGEKVAVLCKENYLLPEAK---EIVCKDGRWQSLPRCVEST 446
I + +NM G+ + C E++ P I C W C+
Sbjct: 330 IKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKC 389
Query: 447 AYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKL-QGSVTVTCRNKQWSEPPRCL 504
+ P + NG + + G ++ C Y L + TVTC WS PRC+
Sbjct: 390 YF----PYLENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/272 (21%), Positives = 103/272 (37%), Gaps = 34/272 (12%)
Query: 287 YQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCK------IAGVNIKT 340
Y G CR Y +GN ++ C G W VA + L++C+ T
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEW------VALNPLRKCQKRPCGHPGDTPFGT 95
Query: 341 LLKLSGKEFNHNSRIRYRCSDIFR----YRHSVCINGKWNPEVDCTEKREQFCPPPPQIP 396
G F + + Y C++ ++ + C W ++ E + C P
Sbjct: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPE 153
Query: 397 NAQNMTTTV----NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCG 450
N + +++ + Y G+ V +C Y + +E+ C DG W + P+CVE +
Sbjct: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC--- 210
Query: 451 PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVS 510
P + NG S + +Y Y+C Y+ C W P C + +
Sbjct: 211 KSPDVINGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDN 269
Query: 511 EENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK 542
N + L+ ++ +TGD + +QC+
Sbjct: 270 PYIPNGDYSPLRIKH------RTGDEITYQCR 295
Score = 34.7 bits (78), Expect = 0.24
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 449 CGPPPSINNGD--TTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQW 497
C P N + T S+ YP G+ Y+C+ Y+ G+V + CR +W
Sbjct: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 114 bits (284), Expect = 3e-25
Identities = 134/484 (27%), Positives = 199/484 (41%), Gaps = 59/484 (12%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRM-CSFPFVKNGHSESSGLIH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG +
Sbjct: 2916 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2971
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWS-TPPICSF-TKGECHVPILEANVDAQPKK 162
G TV C SL + WS + P CS G C P + Q +
Sbjct: 2972 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQ--E 3029
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
+++ ++++C I GS+ C G W+ P CK CG P +NG+V
Sbjct: 3030 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAV--QCGNPGTTANGKVFR 3087
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT-TLPTCVEQVKTCGY--IPE--L 275
I + + + Y C +I++GP QC +G W+ TLP C + +CG IP L
Sbjct: 3088 IDGTTFSSSVI--YSCMEGYILSGPSVRQCTANGTWSGTLPNCT--IISCGDPGIPANGL 3143
Query: 276 EYGYVQPSVPPYQHGVSVEVNCRNEYAMI--GNNMITC-INGIWTE-LPMCVATHQLKRC 331
YG Y G +V C+ Y M G+ + TC ING W+ +P C A
Sbjct: 3144 RYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPP 3197
Query: 332 KIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEV-DCTEKRE 386
+I+ +L G F+ I Y CS + + NG W+ EV C K
Sbjct: 3198 QISNG------RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK-- 3249
Query: 387 QFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRWQ-SLPRCVE 444
FC P + + YQ +V+ C ++L + +C+ DG W S P C+E
Sbjct: 3250 -FCGDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIE 3306
Query: 445 STAYCGPPPSI--NNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSE-P 500
T P + + +F V GS V + C+ + LQGS T TC + WS
Sbjct: 3307 PTQTSCENPGVPRHGSQNNTFGFQV---GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQ 3363
Query: 501 PRCL 504
P C+
Sbjct: 3364 PECI 3367
Score = 99.4 bits (246), Expect = 8e-21
Identities = 117/473 (24%), Positives = 182/473 (38%), Gaps = 49/473 (10%)
Query: 53 YSCE--YNFVSPSKSFWTRITCTEEG-WS-----PTPKCLRMCSFPFVKNGHSESSGLIH 104
+SC+ Y+ + P+ I C G WS P + + P NG+ + +
Sbjct: 2683 FSCDPGYHGLGPAS-----IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY 2737
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES 164
G T C+ G+ L + C+ G + G C +P E V+ Q E+
Sbjct: 2738 --GSTAIFTCDLGFMLVGSAVR-ECLSSGLWSESETRCLAGHCGIP--ELIVNGQVIGEN 2792
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIR 223
Y D + + C +GS C Q WS P+C SCG P G
Sbjct: 2793 YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV--SCGHPGSPIYGRTSG-- 2848
Query: 224 KEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCG--YIPELEYGYVQ 281
+ N+VV + CN +++ GP K QC + P + +V C IP +
Sbjct: 2849 -NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2907
Query: 282 PSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATHQLKRCKIAGVNIK 339
+ +G V +C Y + G++++ C NG W + LP C+ + C GV
Sbjct: 2908 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI----MIDCGHPGVPPN 2963
Query: 340 TLLKLSGKEFNHNSRIRYRCS---DIFRYRHSVC-INGKWN-PEVDCTEKREQFCPPPPQ 394
+ LSG+++ S + Y C+ + C +NG W+ + C+ C P
Sbjct: 2964 AV--LSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGT 3021
Query: 395 IPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRCVESTAYCGPP 452
+ + N++ V C Y+L ++E C +G W P C CG P
Sbjct: 3022 PGHGSRQES--NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KAVQCGNP 3077
Query: 453 PSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG-SVTVTCRNKQWSEP-PRC 503
+ NG F + S+V Y C Y L G SV N WS P C
Sbjct: 3078 GTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 3128
Score = 86.3 bits (212), Expect = 7e-17
Identities = 128/494 (25%), Positives = 195/494 (39%), Gaps = 76/494 (15%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRM-CSFPFVKNGHSESSGLI-- 103
V ++C+ F V S + + + W +P P C + C P + G++
Sbjct: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPT----NGGILTT 2606
Query: 104 -HLEGDTVQIICNTGYSLQNNEKNIS-CVERG-WS----TPPICSFTKGECHVPILEANV 156
+L G V CN GY L + E + C G WS TP T + ILE
Sbjct: 2607 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2666
Query: 157 DAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG---WSPNFPTCKGQVRSCGPPPQ 213
Y+ + FSC +G S++C G W P C Q+ SCG P
Sbjct: 2667 WRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC--QIISCGELPT 2724
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTTLPT-CVEQVKTCGY 271
NG K + YG + + C+ F++ G +C+ G W+ T C+ CG
Sbjct: 2725 PPNGN-KIGTQTSYGSTAI--FTCDLGFMLVGSAVRECLSSGLWSESETRCL--AGHCG- 2778
Query: 272 IPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWT-ELPMCVATHQLK 329
IPEL Q Y + +V C + +IG+++ C + W+ +LP CV
Sbjct: 2779 IPELIVN-GQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV---- 2833
Query: 330 RCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFC 389
C G I + SG FN N + + C+ + + + C R+
Sbjct: 2834 SCGHPGSPIYG--RTSGNGFNFNDVVTFSCNIGYLMQGPT--------KAQCQANRQWSH 2883
Query: 390 PPP---------PQIPNAQNMTTTV---NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW 436
PPP P IP + + N+ G V C Y L + ++C+ +G+W
Sbjct: 2884 PPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQW 2943
Query: 437 -QSLPRCVESTAYCG----PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVT 491
+ LP C+ CG PP ++ +G+ +F GSTV Y C L G + T
Sbjct: 2944 DKPLPECI--MIDCGHPGVPPNAVLSGEKYTF-------GSTVHYSCTGKRSLLGQSSRT 2994
Query: 492 CR-NKQWS-EPPRC 503
C+ N WS P C
Sbjct: 2995 CQLNGHWSGSQPHC 3008
Score = 67.4 bits (163), Expect = 3e-11
Identities = 94/419 (22%), Positives = 164/419 (39%), Gaps = 43/419 (10%)
Query: 110 VQIICNTGYSLQNNEKNI----SCVERGWSTP-PICSFTKGECHVPILEANVDAQPKKES 164
V+ C+ G+ L + S W P P C C +P +A +
Sbjct: 2552 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS--CGIP--KAPTNGGILTTD 2607
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQ---CYQFG-WSPNFPTCKGQVRSCGPPPQ--LSNGE 218
Y VG + + C R+ S + C G WS + T + V +C L +G
Sbjct: 2608 YLVGTRVTYFCNDGY-RLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2666
Query: 219 VKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT---TLPTCVEQVKTCGYIPE 274
+ + Y + V + C+P + GP I+C+ +G W+ P C Q+ +CG +P
Sbjct: 2667 WRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC--QIISCGELPT 2724
Query: 275 LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTEL-PMCVATHQLKRCK 332
G + Y G + C + ++G+ + C+ +G+W+E C+A H C
Sbjct: 2725 PPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGH----CG 2778
Query: 333 IAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS---VC-INGKWNPEVDCTEKREQF 388
I + + ++ G+ + + + Y+C+ FR S +C + W+ ++
Sbjct: 2779 IPELIVNG--QVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2836
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAY 448
P P T+ + + V C YL+ + C+ R S P +
Sbjct: 2837 HPGSP----IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2892
Query: 449 CGPPP-SINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQWSEP-PRCL 504
C P N+ + + G+ V Y C Y L GS + C+ N QW +P P C+
Sbjct: 2893 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951
Score = 46.6 bits (109), Expect = 6e-05
Identities = 81/368 (22%), Positives = 138/368 (37%), Gaps = 63/368 (17%)
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTL---- 259
Q+R C PPP + N E+ +E+ +++ Y C P F + G + C GE +
Sbjct: 2351 QLRVCQPPPPVPNAEILT-EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP 2409
Query: 260 PTCVE-------QVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI 312
P C ++ + G I Y P++ +SVE G N+ +
Sbjct: 2410 PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEK---------GYNITMFV 2460
Query: 313 NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN 372
TE V L+ + L+ LSG +++ I ++F
Sbjct: 2461 EFFQTEKEFDV----LQVYDGPNIQSPVLISLSG-DYSSAFNITSNGHEVFL-------- 2507
Query: 373 GKWNPEVDCTEKREQ------FCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA 426
+W+ + +K + +C P P+ ++ T Q V C + L
Sbjct: 2508 -QWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQT-GGQLNSVVRWACDRGFRLVGK 2565
Query: 427 KEIVCKDG-----RWQS-LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
VC+ W + +P C CG P + NG + + Y G+ VTY C
Sbjct: 2566 SSAVCRKSSYGYHAWDAPVPAC--QAISCGIPKAPTNGGILT---TDYLVGTRVTYFCND 2620
Query: 481 FYKLQGS--VTVTCRNK-QWS---EPPRCLDPCVVSEENMNKNNIQL-KWRNDGKLYAKT 533
Y+L T C++ WS + PRC+ VV+ ++N ++ +WR + +
Sbjct: 2621 GYRLSSKELTTAVCQSDGTWSNHNKTPRCV---VVTCPSINSFILEHGRWRIVNGSHYEY 2677
Query: 534 GDAVEFQC 541
V F C
Sbjct: 2678 KTKVVFSC 2685
Score = 38.1 bits (87), Expect = 0.022
Identities = 25/65 (38%), Positives = 28/65 (43%), Gaps = 9/65 (13%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEP------PR 502
C P +I NG Y GSTVTY C + Y LQG T+TC P P
Sbjct: 1661 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717
Query: 503 CLDPC 507
C PC
Sbjct: 1718 CHAPC 1722
Score = 37.7 bits (86), Expect = 0.029
Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCL 504
C P G F + G T+T+ C S Y+L+G+ + C + WS P PRC+
Sbjct: 1142 CEDPGIPQYGSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Query: 505 DPCVVSEEN 513
C S N
Sbjct: 1199 AECGASATN 1207
Score = 37.4 bits (85), Expect = 0.037
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 5/43 (11%)
Query: 470 PGSTVTYRCQSFYKLQGSVTVTCRNKQ----WS-EPPRCLDPC 507
PG TV ++C Y+LQG +TC + W PP C+ PC
Sbjct: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548
Score = 35.0 bits (79), Expect = 0.18
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 35/137 (25%)
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQCYQF-----GWSPNFPTCKGQVRSCGPPPQLSNGEV 219
+ +G ++FSC ++ + G+ S+ C + WS + P CK V++CG Q +G
Sbjct: 462 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK--VKTCGSNLQGPSGTF 519
Query: 220 KEIRKEEYGHNEVVEYDCNPNFI-----INGPKKIQ----------------CVDGEWTT 258
N +YD N + +N K IQ DG
Sbjct: 520 T-------SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVG 572
Query: 259 LPTCVEQVKTCGYIPEL 275
P V QV T ++P+L
Sbjct: 573 DPRTVLQVLTGSFVPDL 589
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 11/78 (14%)
Query: 436 WQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN- 494
+Q++PR + P P F + GS+V + C Y L GS+ + C
Sbjct: 1827 YQAVPRTSSTQCSSVPEPRFGRRIGNEFAV-----GSSVLFDCNPGYILHGSIAIRCETV 1881
Query: 495 ----KQWSEP-PRCLDPC 507
QW++ P C+ PC
Sbjct: 1882 PNSLAQWNDSLPTCIVPC 1899
Score = 34.3 bits (77), Expect = 0.32
Identities = 57/246 (23%), Positives = 90/246 (36%), Gaps = 47/246 (19%)
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEWT-TLPTCVEQVKTCGYIPELEYGY 279
E+ V +DCNP +I++G I+C +W +LPTC+ V G + + +
Sbjct: 1853 EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI--VPCGGILTKRKGTI 1910
Query: 280 VQPSVP-PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNI 338
+ P P PY + +NC + + GI ++ H N
Sbjct: 1911 LSPGYPEPYDN----NLNC------VWKITVPEGAGIQVQVVSFATEH----------NW 1950
Query: 339 KTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQF---------- 388
+L G + N Y + I +S N N + D + F
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDG---RWQ-SLPRCVE 444
P PQ P++ + Y G+ V+ C + Y L I C G RW +P C+
Sbjct: 2011 SCPEPQTPSS-GIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL- 2068
Query: 445 STAYCG 450
A CG
Sbjct: 2069 --AQCG 2072
Score = 32.3 bits (72), Expect = 1.2
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 468 YPPGSTVTYRCQSFYKLQGSVTVTCRN---KQWSEP-PRCLDPC 507
Y G V+++C Y LQG +TC ++W+ P P CL C
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2071
Score = 31.6 bits (70), Expect = 2.0
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 9/51 (17%)
Query: 226 EYGH--NEVVEYDCNPNFIINGPKKIQCVDGE---WT-TLPTCVEQVKTCG 270
+ GH + Y CNP + ++G ++C+ GE W LP+C+ + CG
Sbjct: 1328 DQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE---CG 1375
Score = 31.2 bits (69), Expect = 2.7
Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 11/69 (15%)
Query: 208 CGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-----VDGEWTT-LPT 261
C P + NG K I + + V++ C+ ++++ G K I C V W+ P
Sbjct: 446 CPDPGEPENG--KRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 502
Query: 262 CVEQVKTCG 270
C +VKTCG
Sbjct: 503 C--KVKTCG 509
Score = 31.2 bits (69), Expect = 2.7
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 3/45 (6%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR 493
C P NG S+ GSTV + C Y LQG+ ++TC+
Sbjct: 446 CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 487
Score = 31.2 bits (69), Expect = 2.7
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 12/56 (21%)
Query: 290 GVSVEVNCRNEYAMIGNNMITCINGI---WTELPMCVATHQLKRCK-IAGVNIKTL 341
G ++ C Y +IGN+ +TC++G+ W H L RC+ + G NI +
Sbjct: 2203 GQTISFECFPGYTLIGNSALTCLHGVSRNW--------NHPLPRCEALCGGNITAM 2250
Score = 30.8 bits (68), Expect = 3.5
Identities = 17/41 (41%), Positives = 25/41 (60%), Gaps = 5/41 (12%)
Query: 104 HLEGDTVQIICNTGYSLQNNEKNISCVE---RGWSTP-PIC 140
++ GD V C+ GYSLQ + +I+C+ R W+ P PIC
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2067
Score = 30.8 bits (68), Expect = 3.5
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 7/63 (11%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR---NKQWSEP-PRCL 504
C P NG +V G T+++ C Y L G+ +TC ++ W+ P PRC
Sbjct: 2184 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2240
Query: 505 DPC 507
C
Sbjct: 2241 ALC 2243
Score = 30.4 bits (67), Expect = 4.6
Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query: 169 DVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTC 201
DVL+F C+ +G S+ C + WS N P C
Sbjct: 644 DVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/35 (42%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
GSTV++ C S Y+L + C +N WS P P C
Sbjct: 989 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 4/41 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPC 507
GST+ Y C Y L GS + C + W P P C+ C
Sbjct: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAEC 1374
Score = 30.4 bits (67), Expect = 4.6
Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 6/39 (15%)
Query: 107 GDTVQIICNTGYSLQNNEKNISCVE----RGWS-TPPIC 140
GDTV C+ GY LQ E+ I+C++ W +PP+C
Sbjct: 1507 GDTVVFQCDPGYELQGEER-ITCIQVENRYFWQPSPPVC 1544
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 114 bits (284), Expect = 3e-25
Identities = 134/484 (27%), Positives = 199/484 (41%), Gaps = 59/484 (12%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRM-CSFPFVKNGHSESSGLIH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG +
Sbjct: 2787 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 2842
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWS-TPPICSF-TKGECHVPILEANVDAQPKK 162
G TV C SL + WS + P CS G C P + Q +
Sbjct: 2843 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQ--E 2900
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
+++ ++++C I GS+ C G W+ P CK CG P +NG+V
Sbjct: 2901 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAV--QCGNPGTTANGKVFR 2958
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT-TLPTCVEQVKTCGY--IPE--L 275
I + + + Y C +I++GP QC +G W+ TLP C + +CG IP L
Sbjct: 2959 IDGTTFSSSVI--YSCMEGYILSGPSVRQCTANGTWSGTLPNCT--IISCGDPGIPANGL 3014
Query: 276 EYGYVQPSVPPYQHGVSVEVNCRNEYAMI--GNNMITC-INGIWTE-LPMCVATHQLKRC 331
YG Y G +V C+ Y M G+ + TC ING W+ +P C A
Sbjct: 3015 RYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPP 3068
Query: 332 KIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEV-DCTEKRE 386
+I+ +L G F+ I Y CS + + NG W+ EV C K
Sbjct: 3069 QISNG------RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK-- 3120
Query: 387 QFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRWQ-SLPRCVE 444
FC P + + YQ +V+ C ++L + +C+ DG W S P C+E
Sbjct: 3121 -FCGDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIE 3177
Query: 445 STAYCGPPPSI--NNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSE-P 500
T P + + +F V GS V + C+ + LQGS T TC + WS
Sbjct: 3178 PTQTSCENPGVPRHGSQNNTFGFQV---GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQ 3234
Query: 501 PRCL 504
P C+
Sbjct: 3235 PECI 3238
Score = 107 bits (266), Expect = 4e-23
Identities = 117/470 (24%), Positives = 182/470 (38%), Gaps = 41/470 (8%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWS---PTPKCLRMC--SFPFVKNGHSESSGLIHLEG 107
Y C + SK T + ++ WS TP+C+ + P NG+ + + G
Sbjct: 2552 YFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTSY--G 2609
Query: 108 DTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKV 167
T C+ G+ L + C+ G + G C +P E V+ Q E+Y
Sbjct: 2610 STAIFTCDLGFMLVGSAVR-ECLSSGLWSESETRCLAGHCGIP--ELIVNGQVIGENYGY 2666
Query: 168 GDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE 226
D + + C +GS C Q WS P+C SCG P G
Sbjct: 2667 RDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV--SCGHPGSPIYGRTSG---NG 2721
Query: 227 YGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCG--YIPELEYGYVQPSV 284
+ N+VV + CN +++ GP K QC + P + +V C IP +
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEH 2781
Query: 285 PPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATHQLKRCKIAGVNIKTLL 342
+ +G V +C Y + G++++ C NG W + LP C+ + C GV +
Sbjct: 2782 GNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI----MIDCGHPGVPPNAV- 2836
Query: 343 KLSGKEFNHNSRIRYRCS---DIFRYRHSVC-INGKWN-PEVDCTEKREQFCPPPPQIPN 397
LSG+++ S + Y C+ + C +NG W+ + C+ C P +
Sbjct: 2837 -LSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGH 2895
Query: 398 AQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRCVESTAYCGPPPSI 455
+ N++ V C Y+L ++E C +G W P C CG P +
Sbjct: 2896 GSRQES--NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KAVQCGNPGTT 2951
Query: 456 NNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG-SVTVTCRNKQWSEP-PRC 503
NG F + S+V Y C Y L G SV N WS P C
Sbjct: 2952 ANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 2999
Score = 105 bits (261), Expect = 1e-22
Identities = 137/484 (28%), Positives = 197/484 (40%), Gaps = 60/484 (12%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRM-CSFPFVKNGHSESSGLI-- 103
V ++C+ F V S + + + W +P P C + C P + G++
Sbjct: 2487 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPT----NGGILTT 2542
Query: 104 -HLEGDTVQIICNTGYSLQNNEKNIS-CVERG-WS----TPPICSFTKGECHVPILEANV 156
+L G V CN GY L + E + C G WS TP + GE P N
Sbjct: 2543 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTP---PNG 2599
Query: 157 DAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLS 215
+ + SY G F+C + VGS +C G WS + C CG P +
Sbjct: 2600 NKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRC--LAGHCGIPELIV 2655
Query: 216 NGEVKEIRKEEYGHNEVVEYDCNPNF-IINGPKKIQCVDGEWT-TLPTCVEQVKTCGYIP 273
NG+V E YG+ + V Y CNP F +I +I D W+ LP+CV +CG+
Sbjct: 2656 NGQV---IGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVP--VSCGHPG 2710
Query: 274 ELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATHQLKRC 331
YG + S + V +C Y M G C N W+ PMC ++ C
Sbjct: 2711 SPIYG--RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMC----KVVNC 2764
Query: 332 KIAGV--NIKTLLKLSGKEFNHNSRIRYRCS-DIFRYRHSVCI---NGKWN-PEVDCTEK 384
G+ N K K+ F + + + Y C+ F + SV I NG+W+ P +C
Sbjct: 2765 SDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMI 2824
Query: 385 REQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCK-ENYLLPEAKEIVCKDGRWQ-SLPRC 442
C P PNA + + Y G V C + LL ++ +G W S P C
Sbjct: 2825 D---CGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 2879
Query: 443 V-ESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS-E 499
++T CG P + +G S + STV Y C + Y L GS TC N W+
Sbjct: 2880 SGDATGTCGDPGTPGHGSRQE---SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGR 2936
Query: 500 PPRC 503
P C
Sbjct: 2937 QPEC 2940
Score = 46.2 bits (108), Expect = 8e-05
Identities = 73/330 (22%), Positives = 122/330 (36%), Gaps = 59/330 (17%)
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTL---- 259
Q+R C PPP + N E+ +E+ +++ Y C P F + G + C GE +
Sbjct: 2287 QLRVCQPPPPVPNAEILT-EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP 2345
Query: 260 PTCVE-------QVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI 312
P C ++ + G I Y P++ +SVE G N+ +
Sbjct: 2346 PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEK---------GYNITMFV 2396
Query: 313 NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN 372
TE V L+ + L+ LSG +++ I ++F
Sbjct: 2397 EFFQTEKEFDV----LQVYDGPNIQSPVLISLSG-DYSSAFNITSNGHEVFL-------- 2443
Query: 373 GKWNPEVDCTEKREQ------FCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA 426
+W+ + +K + +C P P+ ++ T Q V C + L
Sbjct: 2444 -QWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQT-GGQLNSVVRWACDRGFRLVGK 2501
Query: 427 KEIVCKDG-----RWQS-LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
VC+ W + +P C CG P + NG + + Y G+ VTY C
Sbjct: 2502 SSAVCRKSSYGYHAWDAPVPAC--QAISCGIPKAPTNGGILT---TDYLVGTRVTYFCND 2556
Query: 481 FYKLQGS--VTVTCRNK-QWS---EPPRCL 504
Y+L T C++ WS + PRC+
Sbjct: 2557 GYRLSSKELTTAVCQSDGTWSNHNKTPRCV 2586
Score = 38.1 bits (87), Expect = 0.022
Identities = 25/65 (38%), Positives = 28/65 (43%), Gaps = 9/65 (13%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEP------PR 502
C P +I NG Y GSTVTY C + Y LQG T+TC P P
Sbjct: 1597 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653
Query: 503 CLDPC 507
C PC
Sbjct: 1654 CHAPC 1658
Score = 37.7 bits (86), Expect = 0.029
Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCL 504
C P G F + G T+T+ C S Y+L+G+ + C + WS P PRC+
Sbjct: 1078 CEDPGIPQYGSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Query: 505 DPCVVSEEN 513
C S N
Sbjct: 1135 AECGASATN 1143
Score = 37.4 bits (85), Expect = 0.037
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 5/43 (11%)
Query: 470 PGSTVTYRCQSFYKLQGSVTVTCRNKQ----WS-EPPRCLDPC 507
PG TV ++C Y+LQG +TC + W PP C+ PC
Sbjct: 1442 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 11/78 (14%)
Query: 436 WQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN- 494
+Q++PR + P P F + GS+V + C Y L GS+ + C
Sbjct: 1763 YQAVPRTSSTQCSSVPEPRFGRRIGNEFAV-----GSSVLFDCNPGYILHGSIAIRCETV 1817
Query: 495 ----KQWSEP-PRCLDPC 507
QW++ P C+ PC
Sbjct: 1818 PNSLAQWNDSLPTCIVPC 1835
Score = 34.3 bits (77), Expect = 0.32
Identities = 57/246 (23%), Positives = 90/246 (36%), Gaps = 47/246 (19%)
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEWT-TLPTCVEQVKTCGYIPELEYGY 279
E+ V +DCNP +I++G I+C +W +LPTC+ V G + + +
Sbjct: 1789 EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI--VPCGGILTKRKGTI 1846
Query: 280 VQPSVP-PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNI 338
+ P P PY + +NC + + GI ++ H N
Sbjct: 1847 LSPGYPEPYDN----NLNC------VWKITVPEGAGIQVQVVSFATEH----------NW 1886
Query: 339 KTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQF---------- 388
+L G + N Y + I +S N N + D + F
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 1946
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDG---RWQ-SLPRCVE 444
P PQ P++ + Y G+ V+ C + Y L I C G RW +P C+
Sbjct: 1947 SCPEPQTPSS-GIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL- 2004
Query: 445 STAYCG 450
A CG
Sbjct: 2005 --AQCG 2008
Score = 32.3 bits (72), Expect = 1.2
Identities = 47/202 (23%), Positives = 80/202 (39%), Gaps = 31/202 (15%)
Query: 88 SFPFVKNGHSESSGLIHLE-GDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGE 146
SFP + +++ + I E GDT+ +I T + + E+ +E S PP +
Sbjct: 256 SFPNEYHNNADCTWTIVAEPGDTISLIF-TDFQM---EEKYDYLEIEGSEPPTIWLSGMN 311
Query: 147 CHVPIL------------EANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGW 194
PI+ ++N + Y+V + F R + G D+ +
Sbjct: 312 IPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSI-- 369
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC--- 251
N K C P + NG K I + + V++ C+ ++++ G K I C
Sbjct: 370 -LNEGGIKTASNLCPDPGEPENG--KRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRI 425
Query: 252 --VDGEWTT-LPTCVEQVKTCG 270
V W+ P C +VKTCG
Sbjct: 426 AEVFAAWSDHRPVC--KVKTCG 445
Score = 32.3 bits (72), Expect = 1.2
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 468 YPPGSTVTYRCQSFYKLQGSVTVTCRN---KQWSEP-PRCLDPC 507
Y G V+++C Y LQG +TC ++W+ P P CL C
Sbjct: 1964 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2007
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/77 (24%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSE----PPRCL 504
C PPP + N + + + G + Y+C + L G+ +TCR + + PP C
Sbjct: 2291 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2349
Query: 505 DPCVVSEENMNKNNIQL 521
C +E ++ + L
Sbjct: 2350 VLCPANELRLDSTGVIL 2366
Score = 31.6 bits (70), Expect = 2.0
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 9/51 (17%)
Query: 226 EYGH--NEVVEYDCNPNFIINGPKKIQCVDGE---WT-TLPTCVEQVKTCG 270
+ GH + Y CNP + ++G ++C+ GE W LP+C+ + CG
Sbjct: 1264 DQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE---CG 1311
Score = 31.2 bits (69), Expect = 2.7
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 3/45 (6%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR 493
C P NG S+ GSTV + C Y LQG+ ++TC+
Sbjct: 382 CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 423
Score = 31.2 bits (69), Expect = 2.7
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 12/56 (21%)
Query: 290 GVSVEVNCRNEYAMIGNNMITCINGI---WTELPMCVATHQLKRCK-IAGVNIKTL 341
G ++ C Y +IGN+ +TC++G+ W H L RC+ + G NI +
Sbjct: 2139 GQTISFECFPGYTLIGNSALTCLHGVSRNW--------NHPLPRCEALCGGNITAM 2186
Score = 30.8 bits (68), Expect = 3.5
Identities = 17/41 (41%), Positives = 25/41 (60%), Gaps = 5/41 (12%)
Query: 104 HLEGDTVQIICNTGYSLQNNEKNISCVE---RGWSTP-PIC 140
++ GD V C+ GYSLQ + +I+C+ R W+ P PIC
Sbjct: 1964 YMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2003
Score = 30.8 bits (68), Expect = 3.5
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 7/63 (11%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR---NKQWSEP-PRCL 504
C P NG +V G T+++ C Y L G+ +TC ++ W+ P PRC
Sbjct: 2120 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2176
Query: 505 DPC 507
C
Sbjct: 2177 ALC 2179
Score = 30.4 bits (67), Expect = 4.6
Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query: 169 DVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTC 201
DVL+F C+ +G S+ C + WS N P C
Sbjct: 580 DVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/35 (42%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
GSTV++ C S Y+L + C +N WS P P C
Sbjct: 925 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 4/41 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPC 507
GST+ Y C Y L GS + C + W P P C+ C
Sbjct: 1270 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAEC 1310
Score = 30.4 bits (67), Expect = 4.6
Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 6/39 (15%)
Query: 107 GDTVQIICNTGYSLQNNEKNISCVE----RGWS-TPPIC 140
GDTV C+ GY LQ E+ I+C++ W +PP+C
Sbjct: 1443 GDTVVFQCDPGYELQGEER-ITCIQVENRYFWQPSPPVC 1480
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 114 bits (284), Expect = 3e-25
Identities = 134/484 (27%), Positives = 199/484 (41%), Gaps = 59/484 (12%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WS-PTPKCLRM-CSFPFVKNGHSESSGLIH 104
G V +Y C + S + C G W P P+C+ + C P V ++ SG +
Sbjct: 2956 GTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHPGVPP-NAVLSGEKY 3011
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWS-TPPICSF-TKGECHVPILEANVDAQPKK 162
G TV C SL + WS + P CS G C P + Q +
Sbjct: 3012 TFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQ--E 3069
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
+++ ++++C I GS+ C G W+ P CK CG P +NG+V
Sbjct: 3070 SNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAV--QCGNPGTTANGKVFR 3127
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT-TLPTCVEQVKTCGY--IPE--L 275
I + + + Y C +I++GP QC +G W+ TLP C + +CG IP L
Sbjct: 3128 IDGTTFSSSVI--YSCMEGYILSGPSVRQCTANGTWSGTLPNCT--IISCGDPGIPANGL 3183
Query: 276 EYGYVQPSVPPYQHGVSVEVNCRNEYAMI--GNNMITC-INGIWTE-LPMCVATHQLKRC 331
YG Y G +V C+ Y M G+ + TC ING W+ +P C A
Sbjct: 3184 RYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPP 3237
Query: 332 KIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEV-DCTEKRE 386
+I+ +L G F+ I Y CS + + NG W+ EV C K
Sbjct: 3238 QISNG------RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPK-- 3289
Query: 387 QFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRWQ-SLPRCVE 444
FC P + + YQ +V+ C ++L + +C+ DG W S P C+E
Sbjct: 3290 -FCGDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIE 3346
Query: 445 STAYCGPPPSI--NNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSE-P 500
T P + + +F V GS V + C+ + LQGS T TC + WS
Sbjct: 3347 PTQTSCENPGVPRHGSQNNTFGFQV---GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQ 3403
Query: 501 PRCL 504
P C+
Sbjct: 3404 PECI 3407
Score = 99.4 bits (246), Expect = 8e-21
Identities = 117/473 (24%), Positives = 182/473 (38%), Gaps = 49/473 (10%)
Query: 53 YSCE--YNFVSPSKSFWTRITCTEEG-WS-----PTPKCLRMCSFPFVKNGHSESSGLIH 104
+SC+ Y+ + P+ I C G WS P + + P NG+ + +
Sbjct: 2723 FSCDPGYHGLGPAS-----IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY 2777
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES 164
G T C+ G+ L + C+ G + G C +P E V+ Q E+
Sbjct: 2778 --GSTAIFTCDLGFMLVGSAVR-ECLSSGLWSESETRCLAGHCGIP--ELIVNGQVIGEN 2832
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIR 223
Y D + + C +GS C Q WS P+C SCG P G
Sbjct: 2833 YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV--SCGHPGSPIYGRTSG-- 2888
Query: 224 KEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCG--YIPELEYGYVQ 281
+ N+VV + CN +++ GP K QC + P + +V C IP +
Sbjct: 2889 -NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESK 2947
Query: 282 PSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATHQLKRCKIAGVNIK 339
+ +G V +C Y + G++++ C NG W + LP C+ + C GV
Sbjct: 2948 IEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI----MIDCGHPGVPPN 3003
Query: 340 TLLKLSGKEFNHNSRIRYRCS---DIFRYRHSVC-INGKWN-PEVDCTEKREQFCPPPPQ 394
+ LSG+++ S + Y C+ + C +NG W+ + C+ C P
Sbjct: 3004 AV--LSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGT 3061
Query: 395 IPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRCVESTAYCGPP 452
+ + N++ V C Y+L ++E C +G W P C CG P
Sbjct: 3062 PGHGSRQES--NFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC--KAVQCGNP 3117
Query: 453 PSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG-SVTVTCRNKQWSEP-PRC 503
+ NG F + S+V Y C Y L G SV N WS P C
Sbjct: 3118 GTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC 3168
Score = 86.3 bits (212), Expect = 7e-17
Identities = 128/494 (25%), Positives = 195/494 (39%), Gaps = 76/494 (15%)
Query: 50 VFYYSCEYNF--VSPSKSFWTRITCTEEGW-SPTPKCLRM-CSFPFVKNGHSESSGLI-- 103
V ++C+ F V S + + + W +P P C + C P + G++
Sbjct: 2591 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPT----NGGILTT 2646
Query: 104 -HLEGDTVQIICNTGYSLQNNEKNIS-CVERG-WS----TPPICSFTKGECHVPILEANV 156
+L G V CN GY L + E + C G WS TP T + ILE
Sbjct: 2647 DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2706
Query: 157 DAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG---WSPNFPTCKGQVRSCGPPPQ 213
Y+ + FSC +G S++C G W P C Q+ SCG P
Sbjct: 2707 WRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC--QIISCGELPT 2764
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTTLPT-CVEQVKTCGY 271
NG K + YG + + C+ F++ G +C+ G W+ T C+ CG
Sbjct: 2765 PPNGN-KIGTQTSYGSTAI--FTCDLGFMLVGSAVRECLSSGLWSESETRCL--AGHCG- 2818
Query: 272 IPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIWT-ELPMCVATHQLK 329
IPEL Q Y + +V C + +IG+++ C + W+ +LP CV
Sbjct: 2819 IPELIVN-GQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV---- 2873
Query: 330 RCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFC 389
C G I + SG FN N + + C+ + + + C R+
Sbjct: 2874 SCGHPGSPIYG--RTSGNGFNFNDVVTFSCNIGYLMQGPT--------KAQCQANRQWSH 2923
Query: 390 PPP---------PQIPNAQNMTTTV---NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW 436
PPP P IP + + N+ G V C Y L + ++C+ +G+W
Sbjct: 2924 PPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQW 2983
Query: 437 -QSLPRCVESTAYCG----PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVT 491
+ LP C+ CG PP ++ +G+ +F GSTV Y C L G + T
Sbjct: 2984 DKPLPECI--MIDCGHPGVPPNAVLSGEKYTF-------GSTVHYSCTGKRSLLGQSSRT 3034
Query: 492 CR-NKQWS-EPPRC 503
C+ N WS P C
Sbjct: 3035 CQLNGHWSGSQPHC 3048
Score = 67.4 bits (163), Expect = 3e-11
Identities = 94/419 (22%), Positives = 164/419 (39%), Gaps = 43/419 (10%)
Query: 110 VQIICNTGYSLQNNEKNI----SCVERGWSTP-PICSFTKGECHVPILEANVDAQPKKES 164
V+ C+ G+ L + S W P P C C +P +A +
Sbjct: 2592 VRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAIS--CGIP--KAPTNGGILTTD 2647
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQ---CYQFG-WSPNFPTCKGQVRSCGPPPQ--LSNGE 218
Y VG + + C R+ S + C G WS + T + V +C L +G
Sbjct: 2648 YLVGTRVTYFCNDGY-RLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGR 2706
Query: 219 VKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT---TLPTCVEQVKTCGYIPE 274
+ + Y + V + C+P + GP I+C+ +G W+ P C Q+ +CG +P
Sbjct: 2707 WRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC--QIISCGELPT 2764
Query: 275 LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTEL-PMCVATHQLKRCK 332
G + Y G + C + ++G+ + C+ +G+W+E C+A H C
Sbjct: 2765 PPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGH----CG 2818
Query: 333 IAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS---VC-INGKWNPEVDCTEKREQF 388
I + + ++ G+ + + + Y+C+ FR S +C + W+ ++
Sbjct: 2819 IPELIVNG--QVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2876
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAY 448
P P T+ + + V C YL+ + C+ R S P +
Sbjct: 2877 HPGSP----IYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2932
Query: 449 CGPPP-SINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQWSEP-PRCL 504
C P N+ + + G+ V Y C Y L GS + C+ N QW +P P C+
Sbjct: 2933 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2991
Score = 46.6 bits (109), Expect = 6e-05
Identities = 81/368 (22%), Positives = 138/368 (37%), Gaps = 63/368 (17%)
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTL---- 259
Q+R C PPP + N E+ +E+ +++ Y C P F + G + C GE +
Sbjct: 2391 QLRVCQPPPPVPNAEILT-EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP 2449
Query: 260 PTCVE-------QVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI 312
P C ++ + G I Y P++ +SVE G N+ +
Sbjct: 2450 PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEK---------GYNITMFV 2500
Query: 313 NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN 372
TE V L+ + L+ LSG +++ I ++F
Sbjct: 2501 EFFQTEKEFDV----LQVYDGPNIQSPVLISLSG-DYSSAFNITSNGHEVFL-------- 2547
Query: 373 GKWNPEVDCTEKREQ------FCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA 426
+W+ + +K + +C P P+ ++ T Q V C + L
Sbjct: 2548 -QWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQT-GGQLNSVVRWACDRGFRLVGK 2605
Query: 427 KEIVCKDG-----RWQS-LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
VC+ W + +P C CG P + NG + + Y G+ VTY C
Sbjct: 2606 SSAVCRKSSYGYHAWDAPVPAC--QAISCGIPKAPTNGGILT---TDYLVGTRVTYFCND 2660
Query: 481 FYKLQGS--VTVTCRNK-QWS---EPPRCLDPCVVSEENMNKNNIQL-KWRNDGKLYAKT 533
Y+L T C++ WS + PRC+ VV+ ++N ++ +WR + +
Sbjct: 2661 GYRLSSKELTTAVCQSDGTWSNHNKTPRCV---VVTCPSINSFILEHGRWRIVNGSHYEY 2717
Query: 534 GDAVEFQC 541
V F C
Sbjct: 2718 KTKVVFSC 2725
Score = 38.1 bits (87), Expect = 0.022
Identities = 25/65 (38%), Positives = 28/65 (43%), Gaps = 9/65 (13%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEP------PR 502
C P +I NG Y GSTVTY C + Y LQG T+TC P P
Sbjct: 1701 CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757
Query: 503 CLDPC 507
C PC
Sbjct: 1758 CHAPC 1762
Score = 37.7 bits (86), Expect = 0.029
Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 7/69 (10%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCL 504
C P G F + G T+T+ C S Y+L+G+ + C + WS P PRC+
Sbjct: 1182 CEDPGIPQYGSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Query: 505 DPCVVSEEN 513
C S N
Sbjct: 1239 AECGASATN 1247
Score = 37.4 bits (85), Expect = 0.037
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 5/43 (11%)
Query: 470 PGSTVTYRCQSFYKLQGSVTVTCRNKQ----WS-EPPRCLDPC 507
PG TV ++C Y+LQG +TC + W PP C+ PC
Sbjct: 1546 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1588
Score = 35.0 bits (79), Expect = 0.18
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 35/137 (25%)
Query: 165 YKVGDVLKFSCRKNLIRVGSDSVQCYQF-----GWSPNFPTCKGQVRSCGPPPQLSNGEV 219
+ +G ++FSC ++ + G+ S+ C + WS + P CK V++CG Q +G
Sbjct: 502 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK--VKTCGSNLQGPSGTF 559
Query: 220 KEIRKEEYGHNEVVEYDCNPNFI-----INGPKKIQ----------------CVDGEWTT 258
N +YD N + +N K IQ DG
Sbjct: 560 T-------SPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVG 612
Query: 259 LPTCVEQVKTCGYIPEL 275
P V QV T ++P+L
Sbjct: 613 DPRTVLQVLTGSFVPDL 629
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 11/78 (14%)
Query: 436 WQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN- 494
+Q++PR + P P F + GS+V + C Y L GS+ + C
Sbjct: 1867 YQAVPRTSSTQCSSVPEPRFGRRIGNEFAV-----GSSVLFDCNPGYILHGSIAIRCETV 1921
Query: 495 ----KQWSEP-PRCLDPC 507
QW++ P C+ PC
Sbjct: 1922 PNSLAQWNDSLPTCIVPC 1939
Score = 34.3 bits (77), Expect = 0.32
Identities = 57/246 (23%), Positives = 90/246 (36%), Gaps = 47/246 (19%)
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEWT-TLPTCVEQVKTCGYIPELEYGY 279
E+ V +DCNP +I++G I+C +W +LPTC+ V G + + +
Sbjct: 1893 EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI--VPCGGILTKRKGTI 1950
Query: 280 VQPSVP-PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNI 338
+ P P PY + +NC + + GI ++ H N
Sbjct: 1951 LSPGYPEPYDN----NLNC------VWKITVPEGAGIQVQVVSFATEH----------NW 1990
Query: 339 KTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQF---------- 388
+L G + N Y + I +S N N + D + F
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2050
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDG---RWQ-SLPRCVE 444
P PQ P++ + Y G+ V+ C + Y L I C G RW +P C+
Sbjct: 2051 SCPEPQTPSS-GIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL- 2108
Query: 445 STAYCG 450
A CG
Sbjct: 2109 --AQCG 2112
Score = 32.3 bits (72), Expect = 1.2
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 4/44 (9%)
Query: 468 YPPGSTVTYRCQSFYKLQGSVTVTCRN---KQWSEP-PRCLDPC 507
Y G V+++C Y LQG +TC ++W+ P P CL C
Sbjct: 2068 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2111
Score = 31.6 bits (70), Expect = 2.0
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 9/51 (17%)
Query: 226 EYGH--NEVVEYDCNPNFIINGPKKIQCVDGE---WT-TLPTCVEQVKTCG 270
+ GH + Y CNP + ++G ++C+ GE W LP+C+ + CG
Sbjct: 1368 DQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE---CG 1415
Score = 31.2 bits (69), Expect = 2.7
Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 11/69 (15%)
Query: 208 CGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-----VDGEWTT-LPT 261
C P + NG K I + + V++ C+ ++++ G K I C V W+ P
Sbjct: 486 CPDPGEPENG--KRIGSD-FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPV 542
Query: 262 CVEQVKTCG 270
C +VKTCG
Sbjct: 543 C--KVKTCG 549
Score = 31.2 bits (69), Expect = 2.7
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 3/45 (6%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR 493
C P NG S+ GSTV + C Y LQG+ ++TC+
Sbjct: 486 CPDPGEPENGKRIGSDFSL---GSTVQFSCDEDYVLQGAKSITCQ 527
Score = 31.2 bits (69), Expect = 2.7
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 12/56 (21%)
Query: 290 GVSVEVNCRNEYAMIGNNMITCINGI---WTELPMCVATHQLKRCK-IAGVNIKTL 341
G ++ C Y +IGN+ +TC++G+ W H L RC+ + G NI +
Sbjct: 2243 GQTISFECFPGYTLIGNSALTCLHGVSRNW--------NHPLPRCEALCGGNITAM 2290
Score = 30.8 bits (68), Expect = 3.5
Identities = 17/41 (41%), Positives = 25/41 (60%), Gaps = 5/41 (12%)
Query: 104 HLEGDTVQIICNTGYSLQNNEKNISCVE---RGWSTP-PIC 140
++ GD V C+ GYSLQ + +I+C+ R W+ P PIC
Sbjct: 2068 YMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPIC 2107
Score = 30.8 bits (68), Expect = 3.5
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 7/63 (11%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR---NKQWSEP-PRCL 504
C P NG +V G T+++ C Y L G+ +TC ++ W+ P PRC
Sbjct: 2224 CPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCE 2280
Query: 505 DPC 507
C
Sbjct: 2281 ALC 2283
Score = 30.4 bits (67), Expect = 4.6
Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query: 169 DVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTC 201
DVL+F C+ +G S+ C + WS N P C
Sbjct: 684 DVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/35 (42%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
GSTV++ C S Y+L + C +N WS P P C
Sbjct: 1029 GSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 30.4 bits (67), Expect = 4.6
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 4/41 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPC 507
GST+ Y C Y L GS + C + W P P C+ C
Sbjct: 1374 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAEC 1414
Score = 30.4 bits (67), Expect = 4.6
Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 6/39 (15%)
Query: 107 GDTVQIICNTGYSLQNNEKNISCVE----RGWS-TPPIC 140
GDTV C+ GY LQ E+ I+C++ W +PP+C
Sbjct: 1547 GDTVVFQCDPGYELQGEER-ITCIQVENRYFWQPSPPVC 1584
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 113 bits (283), Expect = 4e-25
Identities = 125/501 (24%), Positives = 184/501 (36%), Gaps = 98/501 (19%)
Query: 90 PFVKNGHSESSGLIHLE-GDTVQIICNTG------YSLQNNEKNISCV----ERG-WSTP 137
P + NG S L G TV CN G +SL E I C ERG WS P
Sbjct: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG-ESTIRCTSNDQERGTWSGP 589
Query: 138 -PIC--SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG- 193
P+C S +C + K+ Y D + F C GS ++C
Sbjct: 590 APLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT 649
Query: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV- 252
W P P C+ + C PP L +G + V+Y C+P +++ G K I C+
Sbjct: 650 WDPEIPVCE---KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMP 706
Query: 253 DGEWT-TLPTC-------------------VEQVKTC---GY------------------ 271
G W+ + P C VE V T GY
Sbjct: 707 SGNWSPSAPRCEETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIW 766
Query: 272 ---IPELEYGYVQPSVPP--------------YQHGVSVEVNCRNEYAMIGNNMITCIN- 313
IP + + P PP + +G V C + ++G + C +
Sbjct: 767 FKKIPLCKVIHCHP--PPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSD 824
Query: 314 ----GIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS 368
G W+ P C+ + + RC V L + ++HN + C+ F S
Sbjct: 825 SKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGS 884
Query: 369 VCI----NGKWNPEVD-CTEKREQFCPPPPQIPNAQNMTTTV-NYQDGEKVAVLCKENYL 422
I + W P V C +K CPPPP+ PN + + + G + C + YL
Sbjct: 885 RVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYL 944
Query: 423 LPEAKEIVCK-DGRW-QSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 480
L ++C +G W Q P C E C P ++ P +Y G+ VT C+
Sbjct: 945 LVGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGAVVTLECED 1002
Query: 481 FYKLQGSVTVTCR-NKQWSEP 500
Y L+GS C+ + QW+ P
Sbjct: 1003 GYMLEGSPQSQCQSDHQWNPP 1023
Score = 103 bits (256), Expect = 6e-22
Identities = 134/563 (23%), Positives = 197/563 (34%), Gaps = 114/563 (20%)
Query: 45 VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRMCSFPFVKNGH 96
+ G V YSC F + IT + W P PKC C P V G+
Sbjct: 41 IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100
Query: 97 SESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP---PIC-SFTKGEC-HVPI 151
+ GD+V C T +S+ N K++ C P P C S EC +P+
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSM-NGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 152 LEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTC-KGQVRSCG 209
+ S G + +SC + VG + C G WS PTC + + +S G
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219
Query: 210 PPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDG----EWTTLPTCVEQ 265
P NG+VKE G + C+ + + GP +CV WT +P C E+
Sbjct: 220 RFP---NGKVKEPPILRVG--VTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC-EE 273
Query: 266 VKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE------YAMIGNNMITCI-----NG 314
+ P L ++ S+ +G V C + + +IG + + C G
Sbjct: 274 IFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTG 333
Query: 315 IWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI-- 371
W+ P C + +C + ++ + +N + + C F + S I
Sbjct: 334 TWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC 393
Query: 372 --NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTT-TVNYQDGEKVAVLCKENYLLPEAKE 428
G W P EK C PP I N Q V + G + C Y+L +
Sbjct: 394 NAQGTWEPSAPVCEKE---CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES 450
Query: 429 IVC-KDGRW-QSLPRC----VEST------------------AYCG-------------- 450
I C +G W +P+C E+T + CG
Sbjct: 451 IQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
Query: 451 ------------------PPPSINNGDTTSFPLSVYPPGSTVTYRCQS------FYKLQG 486
PPP I NG T L +P G+TVTY C + L G
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
Query: 487 SVTVTCRNKQ-----WSEP-PRC 503
T+ C + WS P P C
Sbjct: 571 ESTIRCTSNDQERGTWSGPAPLC 593
Score = 99.8 bits (247), Expect = 6e-21
Identities = 104/383 (27%), Positives = 149/383 (38%), Gaps = 41/383 (10%)
Query: 167 VGDVLKFSCRKNLIRVGSDSVQCYQFG-----WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
VG V+++SC +G S+ C W P C+ + P + G K
Sbjct: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKI 102
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW--TTLPTCVEQVK-TCGYIPELEY 277
Y H + V + C NF +NG K + C + W T LPTCV C +P +
Sbjct: 103 RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHN 162
Query: 278 G-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTELPMCVATHQLKRCKIAG 335
G + +V G+SV +C + Y ++G +I C+ +G W+ +P T + RCK G
Sbjct: 163 GHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVP---PTCEEARCKSLG 219
Query: 336 ------VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCING-KWNPEVDCTEKREQF 388
V +L++ G N YR R + G W C E F
Sbjct: 220 RFPNGKVKEPPILRV-GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC---EEIF 275
Query: 389 CPPPPQIPNAQNM-TTTVNYQDGEKVAVLCKE------NYLLPEAKEIVC-----KDGRW 436
CP PP I N +++ + N G V C N++L + C K G W
Sbjct: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335
Query: 437 QS-LPRCVEST-AYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN 494
PRC ST A P P I G S Y TV + C + L+GS + C
Sbjct: 336 SGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNA 395
Query: 495 KQWSEP--PRCLDPCVVSEENMN 515
+ EP P C C +N
Sbjct: 396 QGTWEPSAPVCEKECQAPPNILN 418
Score = 90.1 bits (222), Expect = 5e-18
Identities = 89/328 (27%), Positives = 125/328 (38%), Gaps = 38/328 (11%)
Query: 207 SCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-----VDGEWTTLPT 261
SCG PP + NG + V+ Y C+ F + G K + C VDG W
Sbjct: 22 SCGSPPPILNGRISYY-STPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 262 CVEQVKTCGYIPE--LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIW-- 316
E PE + GY PY+HG SV C+ ++M GN + C N +W
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN---- 372
T LP CV+ L+ + ++ + + Y C + IN
Sbjct: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
Query: 373 GKWNP-EVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLL---PEAKE 428
GKW+ C E R C + PN + + + G C E Y L P ++
Sbjct: 201 GKWSAVPPTCEEAR---CKSLGRFPNGKVKEPPI-LRVGVTANFFCDEGYRLQGPPSSRC 256
Query: 429 IVCKDG-RWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS------F 481
++ G W +P C E +C PP I NG L+ GS VTY C
Sbjct: 257 VIAGQGVAWTKMPVCEE--IFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 482 YKLQGSVTVTC-----RNKQWSEP-PRC 503
+ L G T+ C + WS P PRC
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
Score = 86.3 bits (212), Expect = 7e-17
Identities = 101/404 (25%), Positives = 160/404 (39%), Gaps = 58/404 (14%)
Query: 68 TRITCTEEG-WSPT-PKCLRMC-SFPFVKNG-HSESSGLIHLEGDTVQIICNTGYSLQNN 123
++I C + W P P C + C S P + +G H+ + + + G TV C+ GY L N
Sbjct: 640 SQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGN 699
Query: 124 EKNISCVERG-WS-TPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIR 181
K+I C+ G WS + P C T + E ++ +++ SC+
Sbjct: 700 -KSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRV--------ELVNTSCQDGYQL 750
Query: 182 VGSDSVQCYQFG---WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCN 238
G C W P CK V C PPP + NG+ + E + + V Y+C+
Sbjct: 751 TGHAYQMCQDAENGIWFKKIPLCK--VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD 808
Query: 239 PNFIINGPKKIQCVD-----GEWT-TLPTCVEQ--VKTCGYIPELEYGY-VQPSVPPYQH 289
F + G KK+QC G W+ P C+ V C PE+++GY + + Y H
Sbjct: 809 QGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSH 867
Query: 290 GVSVEVNCRNEYAMIGNNMITC-INGIWTE-LPMCVATH--------QLKRCKIAGVNIK 339
V V+C + M G+ +I C + W +P C+ + G NI
Sbjct: 868 NDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIA 927
Query: 340 TLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWN-PEVDCTEKREQFCPPPPQ 394
F+ I Y C + + G W+ P C E C P
Sbjct: 928 --------RFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN---CSSPAD 976
Query: 395 IPNAQN-MTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW 436
+ Q + YQ G V + C++ Y+L + + C+ D +W
Sbjct: 977 MDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQW 1020
Score = 84.0 bits (206), Expect = 3e-16
Identities = 87/362 (24%), Positives = 147/362 (40%), Gaps = 36/362 (9%)
Query: 47 TGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKCLRMCSFPFVKNGHSESSGLIH 104
+G Y+C+ ++ I C G WSP+ P+C C V+ E
Sbjct: 682 SGMTVDYTCDPGYLLVGNK---SIHCMPSGNWSPSAPRCEETCQH--VRQSLQELPAGSR 736
Query: 105 LEGDTVQIICNTGYSLQNNEKNI-SCVERG--WSTPPICSFTKGECHVPILEAN-VDAQP 160
+E V C GY L + + E G + P+C CH P + N
Sbjct: 737 VE--LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVI--HCHPPPVIVNGKHTGM 792
Query: 161 KKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-----WSPNFPTC--KGQVRSCGPPPQ 213
E++ G+ + + C + +G +QC WS P C V C P P+
Sbjct: 793 MAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC-PNPE 851
Query: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTT-LPTCVEQVKT-CG 270
+ +G Y HN++V DCNP FI+NG + I+C D W +PTC+++ C
Sbjct: 852 VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCP 911
Query: 271 YIPELEYG-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCIN-GIWTE-LPMCVATHQ 327
P+ G + ++ + G+S+ +C Y ++G ++ C + G W++ P C +
Sbjct: 912 PPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNC 971
Query: 328 LKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---HSVC-INGKWNPEVDCTE 383
+ G+ K L K + + + + C D + S C + +WNP +
Sbjct: 972 SSPADMDGIQ-KGL--EPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 1028
Query: 384 KR 385
R
Sbjct: 1029 SR 1030
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 112 bits (281), Expect = 7e-25
Identities = 110/451 (24%), Positives = 189/451 (41%), Gaps = 40/451 (8%)
Query: 67 WTRITCTEEG-WS-----PTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120
W + C G W+ P+ + + S F NG+ G + + G T CNTGY+L
Sbjct: 2598 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNK--IGTLTVYGATAIFTCNTGYTL 2655
Query: 121 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI 180
+ C+ G + G C P + V+ + + D + + C
Sbjct: 2656 VGSHVR-ECLANGLWSGSETRCLAGHCGSP--DPIVNGHISGDGFSYRDTVVYQCNPGFR 2712
Query: 181 RVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP 239
VG+ C Q WS P C +CG P ++G E+ N+VV + CN
Sbjct: 2713 LVGTSVRICLQDHKWSGQTPVCVPI--TCGHPGNPAHGFTNG---SEFNLNDVVNFTCNT 2767
Query: 240 NFIINGPKKIQC-VDGEWTT-LPTC-VEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVN 296
+++ G + QC +G+W++ LPTC V G++ Q +++G+S+ +
Sbjct: 2768 GYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYH 2827
Query: 297 CRNEYAMIGNNMITCI-NGIW-TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSR 354
C+ + ++G++ +TC+ NG+W LP C+A C GV + L+G+ F + +
Sbjct: 2828 CKKGFYLLGSSALTCMANGLWDRSLPKCLAI----SCGHPGVPANAV--LTGELFTYGAV 2881
Query: 355 IRYRC---SDIFRYRHSVC-INGKWNPEV-DCTEKREQFCPPPPQIPNAQNMTTTVNYQD 409
+ Y C + VC + W+ + CT FC P + + +++
Sbjct: 2882 VHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGD--DFKT 2939
Query: 410 GEKVAVLCKENYLLPEAKEIVC-KDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVY 468
+ C+ + L + E C +G W L E+ + CG P + NG S ++
Sbjct: 2940 KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVS-CGNPGTPTNGMIVSSDGILF 2998
Query: 469 PPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS 498
S+V Y C YK G +T C N W+
Sbjct: 2999 --SSSVIYACWEGYKTSGLMTRHCTANGTWT 3027
Score = 99.0 bits (245), Expect = 1e-20
Identities = 122/468 (26%), Positives = 184/468 (39%), Gaps = 40/468 (8%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPT-PKCLRM-CSFPFVKNGHSESSGLIH 104
G Y C+ F S +TC G W + PKCL + C P V ++ +G +
Sbjct: 2821 GMSILYHCKKGFYLLGSS---ALTCMANGLWDRSLPKCLAISCGHPGVP-ANAVLTGELF 2876
Query: 105 LEGDTVQIICNTGYSLQNNEKNISCVERGWS--TPPICSFTKGECHVPILEANVDAQPKK 162
G V C SL N+ + + WS P G C P A+
Sbjct: 2877 TYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAH--GSRLG 2934
Query: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
+ +K +L+FSC GS C G WS P C+ SCG P +NG +
Sbjct: 2935 DDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAV--SCGNPGTPTNGMI-- 2990
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-DGEWT-TLPTCVEQVKTCGYIPELEYGY 279
+ + + V Y C + +G C +G WT T P C + +CG L G
Sbjct: 2991 VSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT--IISCGDPGTLANGI 3048
Query: 280 VQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLKRCKIAGVN 337
+ + VS + N + + I C +G W P+C A + +
Sbjct: 3049 QFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGT 3108
Query: 338 IKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN----GKWNPEVDCTEKREQFCPPPP 393
++ G +F S I Y C D ++ HS ++ G W E+ + FC P
Sbjct: 3109 VE------GSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIP--QCLPVFCGDPG 3160
Query: 394 QIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRWQSL-PRCVESTAYCGP 451
IP A+ + ++ +V CK ++L + VC+ DG W + P C++ P
Sbjct: 3161 -IP-AEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCP 3218
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS 498
P + + Y GSTV +RC+ Y +QGS T TC N WS
Sbjct: 3219 DPGTPHFGIQNSSRG-YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265
Score = 43.9 bits (102), Expect = 4e-04
Identities = 78/303 (25%), Positives = 119/303 (39%), Gaps = 45/303 (14%)
Query: 290 GVSVEVNCRNEYAMIGNNMITCINGI-----WTEL-PMCVATHQLKRCKIAGVNIKTLLK 343
G V C+ Y M+G++ TC W L P+C A C I
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVS----CGIPESPGNG--S 2506
Query: 344 LSGKEFNHNSRIRYRCSDIFRYRHS-----VC-INGKWNPEVDCTEKREQFCPPPPQIPN 397
+G EF +S++ Y C + F+ S VC +G W+ + + CP +
Sbjct: 2507 FTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLS 2566
Query: 398 AQNMTTTVN---YQDGEKVAVLCKENYLLPEAKEIVCK-DGRW---QSLPRC-VESTAYC 449
+ V+ + G +V + C Y L + + C+ +G W P C V S
Sbjct: 2567 EHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSL 2626
Query: 450 GPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS-EPPRCLDPC 507
PP+ N T L+VY G+T + C + Y L GS C N WS RCL
Sbjct: 2627 SFPPNGNKIGT----LTVY--GATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGH 2680
Query: 508 VVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKF--EY 565
S + + +I DG Y D V +QC + + +S R Q+ K+ +
Sbjct: 2681 CGSPDPIVNGHIS----GDGFSYR---DTVVYQCNPGFRLVGTS--VRICLQDHKWSGQT 2731
Query: 566 PIC 568
P+C
Sbjct: 2732 PVC 2734
Score = 40.0 bits (92), Expect = 0.006
Identities = 66/312 (21%), Positives = 111/312 (35%), Gaps = 58/312 (18%)
Query: 204 QVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDG---EWT-TL 259
++++C PP NG + +Y + V ++C P +I+ G + C G W
Sbjct: 2084 ELQNCPDPPPFQNGYMIN---SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPF 2140
Query: 260 PTCVEQVKTCGYIPELEYGYV-QPSVP---------------PYQHGVSVEVNCRNEYAM 303
P C CGY + G + P P P HGV + A+
Sbjct: 2141 PRCDAP---CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAV 2197
Query: 304 IGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIF 363
N+ I +G P ++ + T L+ + N +
Sbjct: 2198 --NDYIAVWDGPDQNSP-----------QLGVFSGNTALETAYSSTNQ----------VL 2234
Query: 364 RYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLL 423
HS NG + ++ + + C PPP +P A+ +T +++ G+ V C Y L
Sbjct: 2235 LKFHSDFSNGGFFV-LNFHAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTL 2293
Query: 424 PEAKEIVCK-DGRWQ---SLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQ 479
+ CK + Q SLP C A C P + G + YP + C
Sbjct: 2294 VGTDILTCKLSSQLQFEGSLPTC---EAQC-PANEVRTGSSGVILSPGYPGNYFNSQTCS 2349
Query: 480 SFYKLQGSVTVT 491
K++ + +T
Sbjct: 2350 WSIKVEPNYNIT 2361
Score = 40.0 bits (92), Expect = 0.006
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 7/71 (9%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR---NKQWSEP-PRCL 504
C PP NG + S Y G +V++ C Y L G +TC+ N+ W+ P PRC
Sbjct: 2088 CPDPPPFQNGYMIN---SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144
Query: 505 DPCVVSEENMN 515
PC + + N
Sbjct: 2145 APCGYNVTSQN 2155
Score = 37.7 bits (86), Expect = 0.029
Identities = 87/419 (20%), Positives = 148/419 (35%), Gaps = 103/419 (24%)
Query: 166 KVGDVLKFSCRKNLIRVGSDSVQCYQF-----GWSPNFPTCKGQVRSCGPPPQLSNGEVK 220
+VG ++FSC N + GS S+ C + WS + P C+ R+CG + +G +
Sbjct: 367 RVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR--ARTCGSNLRGPSGVI- 423
Query: 221 EIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYV 280
+PN+ + CV TT P V +K ELE GY
Sbjct: 424 ----------------TSPNYPVQYEDNAHCVWVITTTDPDKV--IKLAFEEFELERGYD 465
Query: 281 QPSVPPYQHGVSVEVNCRNE--YAMIGNN----MITCINGIWTEL--------PMCVATH 326
+V G + +V Y + G++ +++ N +W L P A +
Sbjct: 466 TLTV-----GDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVY 520
Query: 327 Q-LKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRY---RHSVC-INGKWNPE--- 378
Q +++ I K +G F H + + C F R C N +W+
Sbjct: 521 QEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPS 580
Query: 379 ------VDCTEKREQFCPP--PPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIV 430
+ T P P + N N + + G ++ ++ + + P+ +
Sbjct: 581 CVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLA 640
Query: 431 CKDG-----------RWQSLPRCVESTAYCGPPPSINNGDTTSFPLSV----------YP 469
KD +P + S+ + ++ TT ++ +
Sbjct: 641 VKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHD 700
Query: 470 PG---------------STVTYRC-QSFYKLQGSVTVTC----RNKQWSEP-PRCLDPC 507
PG S+V++ C F K QGS ++TC N WS PRC PC
Sbjct: 701 PGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPC 759
Score = 36.6 bits (83), Expect = 0.064
Identities = 61/253 (24%), Positives = 101/253 (39%), Gaps = 68/253 (26%)
Query: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEG---WS-PTPKCLRMC--------------SF 89
G+ +SC F+ T++TC G WS P P+C+ C +F
Sbjct: 1065 GDSLTFSC---FLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNF 1121
Query: 90 PF-VKNGH-------SESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICS 141
P N H +E+ IHL + Q+ + + + + S+ P+ +
Sbjct: 1122 PSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLKVYDGKDS--------SSRPLGT 1173
Query: 142 FTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTC 201
FTK E IL + + L+F+ GSD+ Q +Q ++ +F
Sbjct: 1174 FTKNELLGLILNSTSNHL----------WLEFNTN------GSDTDQGFQLTYT-SFDLV 1216
Query: 202 KGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGE---W-T 257
K C P + G IR E + + VV Y CNP + ++G + C+ G+ W
Sbjct: 1217 K-----CEDPGIPNYGY--RIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDK 1269
Query: 258 TLPTCVEQVKTCG 270
LP+C+ + CG
Sbjct: 1270 PLPSCIAE---CG 1279
Score = 35.8 bits (81), Expect = 0.11
Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 13/67 (19%)
Query: 449 CGPPPSINNGDT--TSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-----RNKQWSEP- 500
C P +I NG T F L GST+TY+C S YK+ ++TC W +
Sbjct: 1565 CFDPGNIMNGTRVGTDFKL-----GSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVL 1619
Query: 501 PRCLDPC 507
P C PC
Sbjct: 1620 PSCNAPC 1626
Score = 35.4 bits (80), Expect = 0.14
Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 11/78 (14%)
Query: 436 WQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN- 494
+Q++PR S C P G S + GS V + C Y LQGS + C++
Sbjct: 1731 YQAVPRT--SDTQCSSVPEPRYGRRIG---SEFSAGSIVRFECNPGYLLQGSTALHCQSV 1785
Query: 495 ----KQWSEP-PRCLDPC 507
QW++ P C+ PC
Sbjct: 1786 PNALAQWNDTIPSCVVPC 1803
Score = 35.0 bits (79), Expect = 0.18
Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTCRNKQ----WS-EPPRCLDPC 507
G TVT++C Y+LQG +TC W +PP C+ C
Sbjct: 1411 GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAAC 1452
Score = 35.0 bits (79), Expect = 0.18
Identities = 58/269 (21%), Positives = 95/269 (35%), Gaps = 58/269 (21%)
Query: 225 EEYGHNEVVEYDCNPNFIINGPKKIQCVDG---EWT-TLPTCVEQVKTC-GYIPELEYGY 279
+ Y N+V+ + C P + + G I C+ G W P C + TC G + L
Sbjct: 1930 DRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC---IATCGGTLSTLGGVI 1986
Query: 280 VQPSVP-PYQH------------GVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATH 326
+ P P Y + G + N ++ + NG + PM
Sbjct: 1987 LSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMI---- 2042
Query: 327 QLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKRE 386
+ +G ++ L + H + I + SD + R ++
Sbjct: 2043 ----GQFSGTDLPAALLST----THETLIHF-YSDHSQNRQGF--------KLAYQAYEL 2085
Query: 387 QFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDG---RWQ-SLPRC 442
Q CP PP N + + +Y G+ V+ C Y+L + C+ G W PRC
Sbjct: 2086 QNCPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRC 2143
Query: 443 VESTAYCGPPPSINNGDTTSFPLSVYPPG 471
A CG + NG ++Y PG
Sbjct: 2144 ---DAPCGYNVTSQNG-------TIYSPG 2162
Score = 35.0 bits (79), Expect = 0.18
Identities = 16/67 (23%), Positives = 31/67 (46%), Gaps = 3/67 (4%)
Query: 141 SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQC---YQFGWSPN 197
+F +C P + + + +++GD +K+ C VG+D + C Q + +
Sbjct: 2253 AFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGS 2312
Query: 198 FPTCKGQ 204
PTC+ Q
Sbjct: 2313 LPTCEAQ 2319
Score = 33.1 bits (74), Expect = 0.70
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 4/44 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPCVVS 510
G ++T+ C Y+L+G+ +TC + WS P PRC+ C S
Sbjct: 1065 GDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGAS 1108
Score = 33.1 bits (74), Expect = 0.70
Identities = 18/74 (24%), Positives = 34/74 (45%), Gaps = 9/74 (12%)
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEWT-TLPTCVEQVKTCGYIPELEYGY 279
E+ +V ++CNP +++ G + C +W T+P+CV V G +
Sbjct: 1757 EFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV--VPCSGNFTQRRGTI 1814
Query: 280 VQPSVP-PYQHGVS 292
+ P P PY + ++
Sbjct: 1815 LSPGYPEPYGNNLN 1828
Score = 32.7 bits (73), Expect = 0.92
Identities = 18/56 (32%), Positives = 29/56 (51%), Gaps = 13/56 (23%)
Query: 282 PSVPPYQHGVSVE---------VNCRNEYAMIGNNMITCING---IWTE-LPMCVA 324
P +P Y + + E +C YAM G+N +TC++G +W + LP C+A
Sbjct: 1221 PGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIA 1276
Score = 32.0 bits (71), Expect = 1.6
Identities = 30/89 (33%), Positives = 38/89 (42%), Gaps = 7/89 (7%)
Query: 144 KGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCK 202
KG C P + A + S+ GD L F C VG + C Q WS N P+C
Sbjct: 525 KGGCGDPGIPAY--GKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC- 581
Query: 203 GQVRSCGPPPQLSNGEVKEIR-KEEYGHN 230
V SC S+G + EEYG+N
Sbjct: 582 --VFSCFFNFTASSGIILSPNYPEEYGNN 608
Score = 29.6 bits (65), Expect = 7.8
Identities = 14/40 (35%), Positives = 21/40 (52%), Gaps = 4/40 (10%)
Query: 472 STVTYRCQSFYKLQGSVTVTCRN---KQWSEP-PRCLDPC 507
+ V Y C Y + GS T+TC + + W +P P C+ C
Sbjct: 1239 TVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAEC 1278
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 106 bits (264), Expect = 7e-23
Identities = 113/447 (25%), Positives = 172/447 (38%), Gaps = 49/447 (10%)
Query: 90 PFVKNGHSESSGLIHLE-GDTVQIICNTG------YSLQNNEKNISCV----ERG-WSTP 137
P + NG S L G TV CN G +SL E I C ERG WS P
Sbjct: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG-ESTIRCTSNDQERGTWSGP 589
Query: 138 -PIC--SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG- 193
P+C S +C + K+ Y D + F C GS ++C
Sbjct: 590 APLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT 649
Query: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVD 253
W P P C+ + +C Q ++E+ E+V C + + G C D
Sbjct: 650 WDPEIPVCEKE--TC----QHVRQSLQELPAGS--RVELVNTSCQDGYQLTGHAYQMCQD 701
Query: 254 GE----WTTLPTCVEQVKTCGYIPELEYG-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNM 308
E + +P C +V C P + G + + +G V C + ++G
Sbjct: 702 AENGIWFKKIPLC--KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKK 759
Query: 309 ITCIN-----GIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDI 362
+ C + G W+ P C+ + + RC V L + ++HN + C+
Sbjct: 760 LQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPG 819
Query: 363 FRYRHSVCI----NGKWNPEVD-CTEKREQFCPPPPQIPNAQNMTTTV-NYQDGEKVAVL 416
F S I + W P V C +K CPPPP+ PN + + + G +
Sbjct: 820 FIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYS 879
Query: 417 CKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTV 474
C + YLL ++C +G W Q P C E C P ++ P +Y G+ V
Sbjct: 880 CDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGAVV 937
Query: 475 TYRCQSFYKLQGSVTVTCR-NKQWSEP 500
T C+ Y L+GS C+ + QW+ P
Sbjct: 938 TLECEDGYMLEGSPQSQCQSDHQWNPP 964
Score = 103 bits (256), Expect = 6e-22
Identities = 134/563 (23%), Positives = 197/563 (34%), Gaps = 114/563 (20%)
Query: 45 VPTGEVFYYSCEYNFVSPSKSFWTRITC--TEEGWS-PTPKC-----LRMCSFPFVKNGH 96
+ G V YSC F + IT + W P PKC C P V G+
Sbjct: 41 IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100
Query: 97 SESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP---PIC-SFTKGEC-HVPI 151
+ GD+V C T +S+ N K++ C P P C S EC +P+
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSM-NGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 152 LEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTC-KGQVRSCG 209
+ S G + +SC + VG + C G WS PTC + + +S G
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219
Query: 210 PPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDG----EWTTLPTCVEQ 265
P NG+VKE G + C+ + + GP +CV WT +P C E+
Sbjct: 220 RFP---NGKVKEPPILRVG--VTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC-EE 273
Query: 266 VKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE------YAMIGNNMITCI-----NG 314
+ P L ++ S+ +G V C + + +IG + + C G
Sbjct: 274 IFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTG 333
Query: 315 IWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI-- 371
W+ P C + +C + ++ + +N + + C F + S I
Sbjct: 334 TWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRC 393
Query: 372 --NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTT-TVNYQDGEKVAVLCKENYLLPEAKE 428
G W P EK C PP I N Q V + G + C Y+L +
Sbjct: 394 NAQGTWEPSAPVCEKE---CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES 450
Query: 429 IVC-KDGRW-QSLPRC----VEST------------------AYCG-------------- 450
I C +G W +P+C E+T + CG
Sbjct: 451 IQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
Query: 451 ------------------PPPSINNGDTTSFPLSVYPPGSTVTYRCQS------FYKLQG 486
PPP I NG T L +P G+TVTY C + L G
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIG 570
Query: 487 SVTVTCRNKQ-----WSEP-PRC 503
T+ C + WS P P C
Sbjct: 571 ESTIRCTSNDQERGTWSGPAPLC 593
Score = 99.8 bits (247), Expect = 6e-21
Identities = 104/383 (27%), Positives = 149/383 (38%), Gaps = 41/383 (10%)
Query: 167 VGDVLKFSCRKNLIRVGSDSVQCYQFG-----WSPNFPTCKGQVRSCGPPPQLSNGEVKE 221
VG V+++SC +G S+ C W P C+ + P + G K
Sbjct: 43 VGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKI 102
Query: 222 IRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEW--TTLPTCVEQVK-TCGYIPELEY 277
Y H + V + C NF +NG K + C + W T LPTCV C +P +
Sbjct: 103 RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHN 162
Query: 278 G-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWTELPMCVATHQLKRCKIAG 335
G + +V G+SV +C + Y ++G +I C+ +G W+ +P T + RCK G
Sbjct: 163 GHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVP---PTCEEARCKSLG 219
Query: 336 ------VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCING-KWNPEVDCTEKREQF 388
V +L++ G N YR R + G W C E F
Sbjct: 220 RFPNGKVKEPPILRV-GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVC---EEIF 275
Query: 389 CPPPPQIPNAQNM-TTTVNYQDGEKVAVLCKE------NYLLPEAKEIVC-----KDGRW 436
CP PP I N +++ + N G V C N++L + C K G W
Sbjct: 276 CPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTW 335
Query: 437 QS-LPRCVEST-AYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN 494
PRC ST A P P I G S Y TV + C + L+GS + C
Sbjct: 336 SGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNA 395
Query: 495 KQWSEP--PRCLDPCVVSEENMN 515
+ EP P C C +N
Sbjct: 396 QGTWEPSAPVCEKECQAPPNILN 418
Score = 90.1 bits (222), Expect = 5e-18
Identities = 89/328 (27%), Positives = 125/328 (38%), Gaps = 38/328 (11%)
Query: 207 SCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-----VDGEWTTLPT 261
SCG PP + NG + V+ Y C+ F + G K + C VDG W
Sbjct: 22 SCGSPPPILNGRISYY-STPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 262 CVEQVKTCGYIPE--LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGIW-- 316
E PE + GY PY+HG SV C+ ++M GN + C N +W
Sbjct: 81 KCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Query: 317 TELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN---- 372
T LP CV+ L+ + ++ + + Y C + IN
Sbjct: 141 TRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
Query: 373 GKWNP-EVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLL---PEAKE 428
GKW+ C E R C + PN + + + G C E Y L P ++
Sbjct: 201 GKWSAVPPTCEEAR---CKSLGRFPNGKVKEPPI-LRVGVTANFFCDEGYRLQGPPSSRC 256
Query: 429 IVCKDG-RWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS------F 481
++ G W +P C E +C PP I NG L+ GS VTY C
Sbjct: 257 VIAGQGVAWTKMPVCEE--IFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 482 YKLQGSVTVTC-----RNKQWSEP-PRC 503
+ L G T+ C + WS P PRC
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRC 342
Score = 80.1 bits (196), Expect = 5e-15
Identities = 104/437 (23%), Positives = 162/437 (37%), Gaps = 68/437 (15%)
Query: 46 PTGEVFYYSC--------EYNFVSPSKSFWTRITCTEEGWS-PTPKCLR-----MCSFPF 91
P G Y+C E++ + S T WS P P C CS
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH 606
Query: 92 VKNGHSESSGLI-HLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP-PICSFTKGEC-H 148
+ NG+ S + DTV C +G++L+ + + + W P+C K C H
Sbjct: 607 IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE--KETCQH 664
Query: 149 VPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG---WSPNFPTCKGQV 205
V + A + E ++ SC+ G C W P CK V
Sbjct: 665 VRQSLQELPAGSRVE------LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCK--V 716
Query: 206 RSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEWT-TL 259
C PPP + NG+ + E + + V Y+C+ F + G KK+QC G W+
Sbjct: 717 IHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776
Query: 260 PTCVEQ--VKTCGYIPELEYGY-VQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC-INGI 315
P C+ V C PE+++GY + + Y H V V+C + M G+ +I C +
Sbjct: 777 PQCLRSPPVTRCPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNT 835
Query: 316 WTE-LPMCVATH--------QLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR 366
W +P C+ + G NI F+ I Y C +
Sbjct: 836 WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIA--------RFSPGMSILYSCDQGYLLV 887
Query: 367 HSVCI----NGKWN-PEVDCTEKREQFCPPPPQIPNAQN-MTTTVNYQDGEKVAVLCKEN 420
+ G W+ P C E C P + Q + YQ G V + C++
Sbjct: 888 GEALLLCTHEGTWSQPAPHCKEVN---CSSPADMDGIQKGLEPRKMYQYGAVVTLECEDG 944
Query: 421 YLLPEAKEIVCK-DGRW 436
Y+L + + C+ D +W
Sbjct: 945 YMLEGSPQSQCQSDHQW 961
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/299 (24%), Positives = 124/299 (41%), Gaps = 27/299 (9%)
Query: 108 DTVQIICNTGYSLQNNEKNI-SCVERG--WSTPPICSFTKGECHVPILEAN-VDAQPKKE 163
+ V C GY L + + E G + P+C CH P + N E
Sbjct: 679 ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVI--HCHPPPVIVNGKHTGMMAE 736
Query: 164 SYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-----WSPNFPTC--KGQVRSCGPPPQLSN 216
++ G+ + + C + +G +QC WS P C V C P P++ +
Sbjct: 737 NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRC-PNPEVKH 795
Query: 217 GEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTT-LPTCVEQVKT-CGYIP 273
G Y HN++V DCNP FI+NG + I+C D W +PTC+++ C P
Sbjct: 796 GYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
Query: 274 ELEYG-YVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCIN-GIWTE-LPMCVATHQLKR 330
+ G + ++ + G+S+ +C Y ++G ++ C + G W++ P C +
Sbjct: 856 KTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP 915
Query: 331 CKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---HSVC-INGKWNPEVDCTEKR 385
+ G+ K L K + + + + C D + S C + +WNP + R
Sbjct: 916 ADMDGIQ-KGL--EPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSR 971
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 97.4 bits (241), Expect = 3e-20
Identities = 113/487 (23%), Positives = 186/487 (38%), Gaps = 51/487 (10%)
Query: 47 TGEVFYYSCEYNFVSPSKSFWTRITCTEEG-WSPTPKCL-RMCSFPF-VKNGHSESSGLI 103
TG Y+C +V + +TC +G W C+ + C P ++NG E +
Sbjct: 73 TGTTLKYTCLPGYVRSHST--QTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDL 130
Query: 104 HLEGDTVQIICNTGYSLQNNEKNISCVER---GWSTP-PICSFTKGECHVPILEANVDAQ 159
G ++ C+ G+ L + + V+ GWS P P C K C P N
Sbjct: 131 SF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVK--CKPPPDIRNGRHS 187
Query: 160 PKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-----WSPNFPTCKGQVRSCGPPPQL 214
++ Y G + +SC +G S+ C W P+ PTC+ + P +
Sbjct: 188 GEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE---KITCRKPDV 244
Query: 215 SNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTTLPTCVEQVKTCGYIP 273
S+GE+ Y + + + + C F++ G I C D +W P E +C +P
Sbjct: 245 SHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEP-NSCINLP 303
Query: 274 ELEYG----YVQPSVPP-YQHGVSVEVNCRNEYAMIGNNMITCI---NGIWTELPMCVAT 325
++ + Y +P+ Y G + C Y + T I N WT C A
Sbjct: 304 DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEAL 363
Query: 326 HQLKRCKIAGVNIKTLLK-LSGKEFNH-----NSRIRYRCSDIFRYRHSVCINGKWNPEV 379
C +N + + + NH I + C + R+ +G W+P
Sbjct: 364 ----CCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPR- 418
Query: 380 DCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQS- 438
T C PP+I + ++ E++ C + Y+L ++ C W +
Sbjct: 419 --TPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAP 476
Query: 439 LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQW 497
P+C A C P +N S Y VT +C S Y + G ++TC N+ W
Sbjct: 477 APQC---KALCRKPELVNG--RLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTW 531
Query: 498 -SEPPRC 503
E P+C
Sbjct: 532 YPEVPKC 538
Score = 84.7 bits (208), Expect = 2e-16
Identities = 98/397 (24%), Positives = 154/397 (38%), Gaps = 52/397 (13%)
Query: 145 GECHVP---ILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGS-DSVQCYQFG-WSPNFP 199
G C P A +D + +K G LK++C +R S ++ C G W N
Sbjct: 48 GNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYN-T 106
Query: 200 TCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGE---- 255
C + C P +L NG+V+ K + +E+ C+ F + G +C +
Sbjct: 107 FC--IYKRCRHPGELRNGQVE--IKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVG 162
Query: 256 WT-TLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC--- 311
W+ LP C ++ C P++ G Y +G SV +C ++++G+ I+C
Sbjct: 163 WSHPLPQC--EIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
Query: 312 --INGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSV 369
G+W P T + C+ V+ ++ G +N+ I ++C F R S
Sbjct: 221 NETIGVWRPSP---PTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSS 277
Query: 370 CI----NGKWNPEVDCTEKREQFCPPPPQIPNAQ-----NMTTTVNYQDGEKVAVLCKEN 420
I + KWNP E C P IP+A T Y G + C
Sbjct: 278 VIHCDADSKWNPSPPACEPNS--CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPG 335
Query: 421 Y--LLPEAKEIVC-KDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS------VYPPG 471
Y E ++C K+ RW C A C P P +NNG+ T S VY G
Sbjct: 336 YKPTTDEPTTVICQKNLRWTPYQGC---EALCCPEPKLNNGEITQHRKSRPANHCVYFYG 392
Query: 472 STVTYRCQSFYKLQGSVTVTCRNKQWS-EPPRCLDPC 507
+++ C + + + WS P C D C
Sbjct: 393 DEISFSCHETSRFS---AICQGDGTWSPRTPSCGDIC 426
Score = 74.3 bits (181), Expect = 3e-13
Identities = 95/382 (24%), Positives = 146/382 (38%), Gaps = 49/382 (12%)
Query: 207 SCGPPPQLSNGEVKEIRKEE--YGHNEVVEYDCNPNFI-INGPKKIQC-VDGEWTTLPTC 262
+CGPPP LS +I E + ++Y C P ++ + + + C DGEW C
Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
Query: 263 VEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC---INGI-WTE 318
+ K C + EL G V+ G +E +C + +IG+ C G+ W+
Sbjct: 109 I--YKRCRHPGELRNGQVEIKT-DLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSH 165
Query: 319 -LPMCVATHQLKRCKIAGVNIKTLLKLSGKE--FNHNSRIRYRCSDIFRYRHSVCIN--- 372
LP C ++ +CK +I+ + SG+E + + + Y C F I+
Sbjct: 166 PLPQC----EIVKCK-PPPDIRN-GRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTV 219
Query: 373 -----GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK 427
G W P EK P NY+D + C++ ++L +
Sbjct: 220 ENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKD--TIVFKCQKGFVLRGSS 277
Query: 428 EIVC-KDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPL----SVYPPGSTVTYRCQSFY 482
I C D +W P E + C P I + ++P VY G+ + YRC Y
Sbjct: 278 VIHCDADSKWNPSPPACEPNS-CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
Query: 483 K--LQGSVTVTC-RNKQWSEPPRCLDPCVVSEENMNKNNI--QLKWRNDGKLYAKTGDAV 537
K TV C +N +W+ C C E +N I K R GD +
Sbjct: 337 KPTTDEPTTVICQKNLRWTPYQGCEALC-CPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
Query: 538 EFQCKFPHKAMISSPPFRAICQ 559
F C + F AICQ
Sbjct: 396 SFSCH-------ETSRFSAICQ 410
Score = 65.5 bits (158), Expect = 1e-10
Identities = 54/197 (27%), Positives = 80/197 (40%), Gaps = 13/197 (6%)
Query: 10 ISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTR 69
+ W G E C PK+++G + P + V++Y E +F S ++
Sbjct: 352 LRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHC----VYFYGDEISFSCHETSRFSA 407
Query: 70 ITCTEEGWSP-TPKCLRMCSF-PFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNI 127
I + WSP TP C +C+F P + +GH + S + + C+ GY L K +
Sbjct: 408 ICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAK-L 466
Query: 128 SCVERGWSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDS 186
SC WS P P C K C P L N K+ Y + + C VG S
Sbjct: 467 SCSYSHWSAPAPQC---KALCRKPEL-VNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQS 522
Query: 187 VQCY-QFGWSPNFPTCK 202
+ C W P P C+
Sbjct: 523 ITCSGNRTWYPEVPKCE 539
Score = 53.9 bits (128), Expect = 4e-07
Identities = 44/184 (23%), Positives = 75/184 (40%), Gaps = 14/184 (7%)
Query: 11 SWVSTVGGEGTLCDFP-KIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTR 69
+W G +C+FP KI HG Y+ F E Y C+ ++ ++ +
Sbjct: 414 TWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK-----EEIIYECDKGYILVGQA---K 465
Query: 70 ITCTEEGWS-PTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNIS 128
++C+ WS P P+C +C P + NG ++E + V I C++GY + +
Sbjct: 466 LSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITC 525
Query: 129 CVERGW-STPPICSFTKGECHVPILEAN--VDAQPKKESYKVG-DVLKFSCRKNLIRVGS 184
R W P C + E +L + P E K+ +V K S + +
Sbjct: 526 SGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQR 585
Query: 185 DSVQ 188
DS +
Sbjct: 586 DSAR 589
Score = 52.4 bits (124), Expect = 1e-06
Identities = 71/319 (22%), Positives = 122/319 (38%), Gaps = 45/319 (14%)
Query: 269 CGYIPELEYGY---VQPSVPPYQHGVSVEVNCRNEYAMIGNNM-ITC-INGIWTELPMCV 323
CG P L + + + ++ G +++ C Y + +TC +G W C+
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCI 109
Query: 324 ATHQLKRCKIAG------VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCIN----- 372
KRC+ G V IKT + + S+I + CS+ F S
Sbjct: 110 ----YKRCRHPGELRNGQVEIKT-------DLSFGSQIEFSCSEGFFLIGSTTSRCEVQD 158
Query: 373 ---GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEI 429
G +P C + C PPP I N ++ Y G V C + L I
Sbjct: 159 RGVGWSHPLPQCEIVK---CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASI 215
Query: 430 VCKD-----GRWQ-SLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYK 483
C G W+ S P C + T P +++G+ S +Y T+ ++CQ +
Sbjct: 216 SCTVENETIGVWRPSPPTCEKITCR---KPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFV 272
Query: 484 LQGSVTVTC-RNKQWS-EPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQC 541
L+GS + C + +W+ PP C ++ ++ + + R + G + ++C
Sbjct: 273 LRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRC 332
Query: 542 KFPHKAMISSPPFRAICQE 560
P + P ICQ+
Sbjct: 333 -HPGYKPTTDEPTTVICQK 350
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 93.2 bits (230), Expect = 6e-19
Identities = 126/479 (26%), Positives = 188/479 (39%), Gaps = 59/479 (12%)
Query: 53 YSCEYNFVSPSKSFWTRITCTEEGWS-PTPKCLRM-CSFPFVKNGHSESSGLIHLEGDTV 110
Y C F S RI + WS TP C+ + C P HS+ SG + G V
Sbjct: 2740 YQCNAGFRLIGMS--VRICQQDHHWSGKTPFCVLVSCGHPG-SPPHSQMSGDSYTVGAVV 2796
Query: 111 QIICNTGYSLQNNEKNISCVERGWS-TPPICSFTK-GECHVPILEANVDAQPKKESYKVG 168
+ C +L N + ++ W+ + P CS T G C P + A+ +S+ G
Sbjct: 2797 RYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAH--GIRLGDSFDPG 2854
Query: 169 DVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEY 227
V++FSC + GS C G WS + P C V SCG P SN V + +
Sbjct: 2855 TVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECG--VISCGNPGTPSNARV--VFSDGL 2910
Query: 228 GHNEVVEYDCNPNFIINGPKKIQC-VDGEWT-TLPTCVEQVKTCGYIPELEYGYVQPSVP 285
+ + Y+C + G C V+G WT + P C+ V CG P +P
Sbjct: 2911 VFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECL--VINCG----------DPGIP 2958
Query: 286 P--------YQHGVSVEVNCRNEYAMIGN--NMITCING-IWTEL-PMCVATHQLKRCKI 333
+++ +V C Y M + ++++C W P+C A CK
Sbjct: 2959 ANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKAL----MCKP 3014
Query: 334 AGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEVDCTEKREQFC 389
+ K+ G +F S + Y C + ++ NG W E+ + FC
Sbjct: 3015 PPLIPNG--KVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP--QCFPVFC 3070
Query: 390 PPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGRWQSL-PRCVESTA 447
P + +Y+ V+ C +L + C+ DG W P C++ T
Sbjct: 3071 GDPGVPSRGRREDRGFSYRSS--VSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTL 3128
Query: 448 YCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWS-EPPRCL 504
P + + Y GSTV +RCQ Y LQGS T TC N WS PP C+
Sbjct: 3129 TTCADPGVPQFGIQNNSQG-YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCV 3186
Score = 88.2 bits (217), Expect = 2e-17
Identities = 137/534 (25%), Positives = 196/534 (36%), Gaps = 102/534 (19%)
Query: 70 ITCTEEG-WS-----PTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNN 123
I C G WS PT + + P NGH G + + G T CN+GY+L +
Sbjct: 2636 IRCQANGKWSLGDSTPTCRIISCGELPIPPNGHR--IGTLSVYGATAIFSCNSGYTLVGS 2693
Query: 124 EKNISCVERG-WSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRV 182
C+ G WS + G C P E V+ E+Y + + C +
Sbjct: 2694 RVR-ECMANGLWSGSEVRCLA-GHCGTP--EPIVNGHINGENYSYRGSVVYQCNAGFRLI 2749
Query: 183 GSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNF 241
G C Q WS P C + SCG P + ++ + Y VV Y C
Sbjct: 2750 GMSVRICQQDHHWSGKTPFC--VLVSCGHPGSPPHSQMS---GDSYTVGAVVRYSCIGKR 2804
Query: 242 IINGPKKIQC-VDGEWT-TLPTCV-EQVKTCGYIPELEYGYVQPSVP--------PYQHG 290
+ G C +DG WT +LP C V CG P +P + G
Sbjct: 2805 TLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCG----------DPGIPAHGIRLGDSFDPG 2854
Query: 291 VSVEVNCRNEYAMIGNNMITC-INGIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLS-GK 347
+ +C + + G++ TC NG W+ P C + C G + S G
Sbjct: 2855 TVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC----GVISCGNPGTPSNARVVFSDGL 2910
Query: 348 EFNHNSRIRYRCSDIF-----RYRHSVCINGKW---NPE---VDCTEKREQFCPPPPQIP 396
F +S I Y C + + RH +NG W +PE ++C + P IP
Sbjct: 2911 VF--SSSIVYECREGYYATGLLSRH-CSVNGTWTGSDPECLVINCGD---------PGIP 2958
Query: 397 NAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIV---CKDGRWQ-SLPRCVESTAYCGPP 452
A + +++ + V C Y++ + V KD W + P C C PP
Sbjct: 2959 -ANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVC--KALMCKPP 3015
Query: 453 PSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR-NKQWS-EPPRCL-----D 505
P I NG S + GS+VTY C Y+L TC N W+ E P+C D
Sbjct: 3016 PLIPNGKVVG---SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGD 3072
Query: 506 PCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQ 559
P V S + +V F C P ++ SP R CQ
Sbjct: 3073 PGVPSRGRREDRGFSYR------------SSVSFSC-HPPLVLVGSP--RRFCQ 3111
Score = 57.8 bits (138), Expect = 3e-08
Identities = 103/471 (21%), Positives = 172/471 (36%), Gaps = 96/471 (20%)
Query: 146 ECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQC-----YQFGWSPNFPT 200
+C P + N + + E + +GD++++ C VG++ + C QF P P
Sbjct: 2293 KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPP--PI 2350
Query: 201 CK-------------GQVRSCGPP---PQLSNGEVKEIRKEEYGHNEVVEYDCNPN---- 240
C+ G + S P PQ + +Y + VEY +
Sbjct: 2351 CEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDE 2410
Query: 241 -FIINGPK----KIQCVDGEWTTLPTCVEQVKTCGYIP------------ELEYGYVQPS 283
I +GP ++ + G ++ P V Y+ ++ Y S
Sbjct: 2411 FEIFDGPSGQSPLLKALSGNYSA-PLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCS 2469
Query: 284 VP------------PYQHGVSVEVNCRNEYAMIGNNMITCIN-----GIWTE-LPMCVAT 325
+P Q G S+ C Y ++G++M C +W+E +P+C
Sbjct: 2470 LPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC--- 2526
Query: 326 HQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSV-----CIN-GKWNPEV 379
Q C + + + GKE+ ++ Y CS+ + + C++ G W+
Sbjct: 2527 -QALSCGLPEAPKNGM--VFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRN 2583
Query: 380 DCTEKREQFCPPPPQIP---NAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK-DGR 435
+ CP I + YQ ++ ++C Y + I C+ +G+
Sbjct: 2584 VPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGK 2643
Query: 436 W---QSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC 492
W S P C CG P NG LSVY G+T + C S Y L GS C
Sbjct: 2644 WSLGDSTPTC--RIISCGELPIPPNGHRIG-TLSVY--GATAIFSCNSGYTLVGSRVREC 2698
Query: 493 -RNKQWS-EPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQC 541
N WS RCL + E + +I +G+ Y+ G V +QC
Sbjct: 2699 MANGLWSGSEVRCLAGHCGTPEPIVNGHI------NGENYSYRGSVV-YQC 2742
Score = 43.5 bits (101), Expect = 5e-04
Identities = 110/468 (23%), Positives = 167/468 (35%), Gaps = 103/468 (22%)
Query: 84 LRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCV---ERGWSTP-PI 139
L C P V +S GL GDT+ C GY L+ + I+C+ R WS+P P
Sbjct: 1036 LEPCEEPEVP-AYSIRKGLQFGVGDTLTFSCFPGYRLEGTAR-ITCLGGRRRLWSSPLPR 1093
Query: 140 C--------SFTKGECHVPILEAN----------VDAQP------KKESYKV--GDVLK- 172
C + T+G P N + QP K ++++ GDVLK
Sbjct: 1094 CVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKV 1153
Query: 173 FSCRKNLIRVGSDSVQCYQFGWSPNFP--------------TCKG--------QVRSCGP 210
+ N R+ G + N T KG ++ C
Sbjct: 1154 YDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCED 1213
Query: 211 PPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTT----LPTCVEQV 266
P G ++ E + V + C+P + + G +++ C+ GE T LPTCV +
Sbjct: 1214 PGTPKFGY--KVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE- 1270
Query: 267 KTCG--YIPELEYGYVQPSVP-PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCV 323
CG E+ + P P PY+H ++ E C G+ +
Sbjct: 1271 --CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAG--------CTIGLHFLVFDTE 1320
Query: 324 ATHQLKRCKIAGVNIKTLLK-LSGKEF------NHNSRIRYRCSDIFRYRHSVCINGKWN 376
H + R V LLK LSG NS + +D F + I +
Sbjct: 1321 EVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVS 1380
Query: 377 PEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCK--DG 434
C + P IP + +++ G+ C Y L + EI C +
Sbjct: 1381 TATSCND---------PGIPQ-NGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIEN 1430
Query: 435 R--WQ-SLPRCVESTAYCGPPPSINNGDTTS--FPLSVYPPGSTVTYR 477
R WQ S P C+ A CG + +G S +P YPPG ++
Sbjct: 1431 RFFWQPSPPTCI---APCGGDLTGPSGVILSPNYP-EPYPPGKECDWK 1474
Score = 43.1 bits (100), Expect = 7e-04
Identities = 74/312 (23%), Positives = 112/312 (35%), Gaps = 48/312 (15%)
Query: 207 SCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDG---EWT-TLPTC 262
SC P SNG VK E Y N+VV + C P + + G I C+ G W P C
Sbjct: 1908 SCPEPAVPSNG-VKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Query: 263 VEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAM-IGNNMITCINGIWTELPM 321
+ Q CG E G + P + ++C + A+ +G TE
Sbjct: 1965 IAQ---CGGTVEEMEGVILS--PGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTE--- 2016
Query: 322 CVATHQLKRCKIAGVNIKTLL-KLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVD 380
H + ++ + SG E S + + Y HS D
Sbjct: 2017 --PNHDYIEIRNGPYETSRMMGRFSGSELP--SSLLSTSHETTVYFHS-----------D 2061
Query: 381 CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLP 440
++ R F + + +++ + G ++ L + N P A V W P
Sbjct: 2062 HSQNRPGFKLEYQDLTYSHQISSFLR---GFDLSELERTNSTPPVAASYV-----WDLDP 2113
Query: 441 RC-VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCR---NKQ 496
C C P NG + Y G +VT+ C Y+L G +TC+ N+
Sbjct: 2114 GCEAYELQECPDPEPFANGIVRG---AGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRN 2170
Query: 497 WSEP-PRCLDPC 507
W P P+C PC
Sbjct: 2171 WDHPLPKCEVPC 2182
Score = 41.2 bits (95), Expect = 0.003
Identities = 80/372 (21%), Positives = 128/372 (34%), Gaps = 76/372 (20%)
Query: 164 SYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKG-QVRSCGPPPQLSNGEVKEI 222
S+++ L+ L R S + W + P C+ +++ C P +NG V
Sbjct: 2079 SHQISSFLRGFDLSELERTNSTPPVAASYVWDLD-PGCEAYELQECPDPEPFANGIV--- 2134
Query: 223 RKEEYGHNEVVEYDCNPNFIINGPKKIQCVDG---EWT-TLPTCVEQVKTCGYIPELEYG 278
R Y + V ++C P + + G + C G W LP C +V G I
Sbjct: 2135 RGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC--EVPCGGNITSSNGT 2192
Query: 279 YVQPSVP---------------PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELP-MC 322
P P P HGV + ++ + IT +G P +
Sbjct: 2193 VYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP--SGDFITIWDGPQQTAPRLG 2250
Query: 323 VATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCT 382
V T + + + + + LLK F+ ++ IF S K
Sbjct: 2251 VFTRSMAKKTVQSSSNQVLLK-----FHRDAAT----GGIFAIAFSAYPLTK-------- 2293
Query: 383 EKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRC 442
CPPP +PNA+ +T + G+ V C + L + + CK G +
Sbjct: 2294 ------CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTY------ 2341
Query: 443 VESTAYCGPPPSIN--------NGDTTSFPLSVYPPGSTVTY-------RCQSFYKLQGS 487
+ GPPP D+T LS PGS + R + Y + +
Sbjct: 2342 ---LQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLT 2398
Query: 488 VTVTCRNKQWSE 499
V KQ+ E
Sbjct: 2399 VEYFLSEKQYDE 2410
Score = 39.7 bits (91), Expect = 0.008
Identities = 23/65 (35%), Positives = 32/65 (49%), Gaps = 9/65 (13%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-----RNKQWSEP-PR 502
C P SI NG L + GS+VTY C Y+++G+ T++C W+ P P
Sbjct: 1558 CFDPGSIKNGTRVGSDLKL---GSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPV 1614
Query: 503 CLDPC 507
C PC
Sbjct: 1615 CTAPC 1619
Score = 38.5 bits (88), Expect = 0.017
Identities = 17/41 (41%), Positives = 25/41 (60%), Gaps = 4/41 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPC 507
G T+T+ C Y+L+G+ +TC R + WS P PRC+ C
Sbjct: 1058 GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAEC 1098
Score = 35.0 bits (79), Expect = 0.18
Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 11/78 (14%)
Query: 436 WQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC--- 492
+Q++PR S C P G SV G+ V + C S Y LQGS + C
Sbjct: 1724 YQAVPRT--SATQCSSVPEPRYGKRLGSDFSV---GAIVRFECNSGYALQGSPEIECLPV 1778
Query: 493 --RNKQWS-EPPRCLDPC 507
QW+ P C+ PC
Sbjct: 1779 PGALAQWNVSAPTCVVPC 1796
Score = 34.7 bits (78), Expect = 0.24
Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 8/70 (11%)
Query: 443 VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQ----WS 498
V + C P NG + + G + ++C Y LQGS ++C + W
Sbjct: 1379 VSTATSCNDPGIPQNGSRSG---DSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQ 1435
Query: 499 -EPPRCLDPC 507
PP C+ PC
Sbjct: 1436 PSPPTCIAPC 1445
Score = 33.9 bits (76), Expect = 0.41
Identities = 15/39 (38%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC-RNKQWS-EPPRCLDPC 507
G T+ + CQ ++L G +TC +N QWS + P C+ C
Sbjct: 540 GDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578
Score = 32.7 bits (73), Expect = 0.92
Identities = 69/302 (22%), Positives = 107/302 (35%), Gaps = 73/302 (24%)
Query: 207 SCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTTLPTCVEQ 265
SCG P + G + R + H + ++++C P F + G K I C + +W+
Sbjct: 520 SCGDPGIPAYGRREGSR---FHHGDTLKFECQPAFELVGQKAITCQKNNQWS-------- 568
Query: 266 VKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI------------- 312
K G + + + PS GV + N +Y N + C+
Sbjct: 569 AKKPGCVFSCFFNFTSPS------GVVLSPNYPEDY----GNHLHCVWLILARPESRIHL 618
Query: 313 --NGIWTELP---MCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH 367
N I E + + + G L S H +R+ F+ H
Sbjct: 619 AFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLE------FQTDH 672
Query: 368 SVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK 427
S GK + T R CP P N + ++ Q G ++ LC E +L +
Sbjct: 673 S---TGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSL--QLGSSISFLCDEGFLGTQGS 727
Query: 428 E---IVCKDGR--WQS-LPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSF 481
E V K+G W S + RC A CG G TS P G+ ++ F
Sbjct: 728 ETITCVLKEGSVVWNSAVLRC---EAPCG-------GHLTS------PSGTILSPGWPGF 771
Query: 482 YK 483
YK
Sbjct: 772 YK 773
Score = 31.6 bits (70), Expect = 2.0
Identities = 20/70 (28%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRN---KQWS-EPPRCL 504
C P +NG T Y V+++C+ Y LQG ++C ++W+ PP C+
Sbjct: 1909 CPEPAVPSNGVKTG---ERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965
Query: 505 DPCVVSEENM 514
C + E M
Sbjct: 1966 AQCGGTVEEM 1975
Score = 30.0 bits (66), Expect = 5.9
Identities = 17/49 (34%), Positives = 25/49 (51%), Gaps = 7/49 (14%)
Query: 107 GDTVQIICNTGYSLQNNEKNISCVE-----RGWST-PPICSFTKGECHV 149
G +VQ CN GY LQ + K I+C++ WS P+C + H+
Sbjct: 362 GSSVQFTCNEGYDLQGS-KRITCMKVSDMFAAWSDHRPVCRARMCDAHL 409
Score = 30.0 bits (66), Expect = 5.9
Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 4/41 (9%)
Query: 471 GSTVTYRCQSFYKLQGSVTVTC---RNKQWSEP-PRCLDPC 507
GS+V++ C Y L+GS + C + W P P C+ C
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAEC 1271
Score = 30.0 bits (66), Expect = 5.9
Identities = 18/74 (24%), Positives = 35/74 (47%), Gaps = 9/74 (12%)
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-----GEW-TTLPTCVEQVKTCGYIPELEYGY 279
++ +V ++CN + + G +I+C+ +W + PTCV V G + E
Sbjct: 1750 DFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCV--VPCGGNLTERRGTI 1807
Query: 280 VQPSVP-PYQHGVS 292
+ P P PY + ++
Sbjct: 1808 LSPGFPEPYLNSLN 1821
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 89.7 bits (221), Expect = 6e-18
Identities = 122/517 (23%), Positives = 192/517 (37%), Gaps = 86/517 (16%)
Query: 44 QVPTGEVFYYSCE-------YNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGH 96
+ P G Y C ++ + S WT S KC R +N
Sbjct: 54 EFPIGTYLNYECRPGYSGRPFSIICLKNSVWT---------SAKDKCKRKSC----RNPP 100
Query: 97 SESSGLIHLEGDT-----VQIICNTGYSLQNNEKNISCVERG----WSTP-PICSFTKGE 146
+G+ H+ D ++ C GY L + + +C+ G W P+C +
Sbjct: 101 DPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSS-SATCIISGNTVIWDNKTPVCD--RII 157
Query: 147 CHVPILEANVD-AQPKKESYKVGDVLKFSC------RKNLIRVGSDSVQCY----QFG-W 194
C +P AN D +E + G V+ + C +K VG S+ C Q G W
Sbjct: 158 CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQC-VD 253
S P C + + PP + NG + + + NEVVE+ C P F + GP ++C
Sbjct: 218 SGPAPQCI--IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQAL 275
Query: 254 GEW-TTLPTCVEQVKTCGYIPE-LEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITC 311
+W LP+C + C P+ L Q + G V +C Y + G+ + C
Sbjct: 276 NKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC 332
Query: 312 I-NGIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR--- 366
G W+ P C ++K C + L +++ + C + F+ +
Sbjct: 333 TPQGDWSPAAPRC----EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSS 388
Query: 367 HSVCI----NGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYL 422
S C+ WN V E++ PP P + ++ T ++ G ++ C +
Sbjct: 389 ASYCVLAGMESLWNSSVPVCERKSCETPPVP-VNGMVHVITDIHV--GSRINYSCTTGHR 445
Query: 423 LPEAKEIVC----KDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRC 478
L C W P + +C PP+I NG T PL P G V+Y C
Sbjct: 446 LIGHSSAECILSGNTAHWSMKPPICQQ-IFCPNPPAILNGRHTGTPLGDIPYGKEVSYTC 504
Query: 479 QSF------YKLQGSVTVTCR-----NKQWSEP-PRC 503
+ L G T+ N WS P PRC
Sbjct: 505 DPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 88.2 bits (217), Expect = 2e-17
Identities = 93/356 (26%), Positives = 140/356 (39%), Gaps = 33/356 (9%)
Query: 112 IICNTGYSLQNNEKNISCVERG-WSTP-PICSFTKGECHVPILEAN--VDAQPKKESYKV 167
I C+ GY L ++ + + C+ G WS P P C+ EC AN V+ S+
Sbjct: 208 ISCDRGY-LPSSMETMQCMSSGEWSAPIPACNVV--ECDAVTNPANGFVECFQNPGSFPW 264
Query: 168 GDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKE- 225
F C + +G+ S+QC G W PTCK +C Q NG V+
Sbjct: 265 NTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAV--TCRAVRQPQNGSVRCSHSPA 322
Query: 226 -EYGHNEVVEYDCNPNFIINGPKKIQC-VDGEWT-TLPTCVEQVKTCGYIPELEYGYVQP 282
E+ + C F++ GP +++C G+WT +P C T PE Y P
Sbjct: 323 GEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLP 382
Query: 283 SVP-PYQHGVSVEVNCRNEYAMIGNNMITC-INGIW-TELPMCVATHQLKRCKIAGVNIK 339
S +++G S E +C + + G+ + C G W E P C A RC K
Sbjct: 383 SASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAV----RCDAVHQPPK 438
Query: 340 TLLKLSGK---EFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEVDCTEKREQFCPPP 392
L++ + EF + S + C + F S + G+W EV + + C
Sbjct: 439 GLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVK--C-SS 495
Query: 393 PQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRCVEST 446
+P NM+ + G C E + L + C G W LP C T
Sbjct: 496 LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPT 551
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/299 (20%), Positives = 120/299 (40%), Gaps = 32/299 (10%)
Query: 227 YGHNEVVEYDCNPNFIINGPKKIQCV-DGEWTT-LPTCVEQVKTCGYIPELEYGYVQPSV 284
+ +N C+ ++ + + +QC+ GEW+ +P C V C + G+V+
Sbjct: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC--NVVECDAVTNPANGFVECFQ 257
Query: 285 PP--YQHGVSVEVNCRNEYAMIGNNMITCI-NGIW-TELPMCVATHQLKRCKIAGVNIKT 340
P + + +C + ++G + C +G W E P C A + +++
Sbjct: 258 NPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRC 317
Query: 341 LLKLSGKEFNHNSRIRYRCSDIFRYRHSVCI----NGKWNPEVDCTEKREQFCPPPPQ-- 394
+G EF S + C + F + + G+W ++ E + P+
Sbjct: 318 SHSPAG-EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
Query: 395 ----IPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVC-KDGRWQS-LPRC--VEST 446
+P+A +++ G C++ ++L +K + C G W + P C V
Sbjct: 377 YMNCLPSASG-----SFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCD 431
Query: 447 AYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWSEP-PRC 503
A PP + P+ + S+ + C+ ++L GS + C ++ QW+E P C
Sbjct: 432 AVHQPPKGLVR--CAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSC 488
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 87.4 bits (215), Expect = 3e-17
Identities = 106/423 (25%), Positives = 176/423 (41%), Gaps = 56/423 (13%)
Query: 114 CNTGYSLQNNEKNISCVERG-WST-PPICSFTKGECHVPILE----ANVDAQPKKESYKV 167
C GY + N + C+ G W+ PP C +C P L+ N+ ++++
Sbjct: 230 CTDGYQV-NGPSKLECLASGIWTNKPPQC--LAAQC--PPLKIPERGNMTCLHSAKAFQH 284
Query: 168 GDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKG-QVRSCGPPPQLSNGEVKEIRKE 225
FSC + VG + VQC G W+ P CK Q + P + + V +
Sbjct: 285 QSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344
Query: 226 EYGHNEVVEYDCNPNFIINGPKKIQCVD-GEWTT-LPTCVEQVKTCGYIPELEYGYVQ-- 281
YG + +++C P + + G ++C+D G W+ LPTC + +C + +G +
Sbjct: 345 AYGSS--CKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC--EAISCEPLESPVHGSMDCS 400
Query: 282 PSVPPYQHGVSVEVNCRNEYAMIGNNMITCIN-GIWTE-LPMCVATHQLKRCKIAGVNIK 339
PS+ +Q+ + C + + G +++ C N G WT P+C Q +C+ V +
Sbjct: 401 PSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC----QALQCQDLPVPNE 456
Query: 340 TLLKLSGK--EFNHNSRIRYRCSD-IFRYRHSV--CI-NGKWNP-EVDCTEKREQFCPPP 392
+ S F + S + C++ + SV C+ G WN +C Q P
Sbjct: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC-----QAIPCT 511
Query: 393 PQIPNAQNMTTTVNYQDGEK-----VAVLCKENYLLPEAKEIVC-KDGRWQSLPRCVEST 446
P + + QN T T G +C E Y L + + C + GRW P E+
Sbjct: 512 PLL-SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
Query: 447 A----YCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWS-EP 500
+ S++ DT + GST + C + +KL+G V C +WS P
Sbjct: 571 KCPELFAPEQGSLDCSDTRG----EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATP 626
Query: 501 PRC 503
P C
Sbjct: 627 PTC 629
Score = 76.3 bits (186), Expect = 7e-14
Identities = 91/387 (23%), Positives = 151/387 (39%), Gaps = 32/387 (8%)
Query: 138 PICSFTK--GECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-W 194
P C + + GE +P ++ ++ F C G ++C G W
Sbjct: 192 PECEYVRECGELELP-QHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW 250
Query: 195 SPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE-YGHNEVVEYDCNPNFIINGPKKIQC-V 252
+ P C C P G + + + + H + C F + GP+ +QC
Sbjct: 251 TNKPPQCLAA--QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTA 308
Query: 253 DGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVP--PYQHGVSVEVNCRNEYAMIGNNMIT 310
G WT P V + C ++ G + P + +G S + C+ Y + G +M+
Sbjct: 309 SGVWTA-PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR 367
Query: 311 CI-NGIWT-ELPMC--VATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR 366
CI +G W+ LP C ++ L+ ++ L + F +++ +RC++ F R
Sbjct: 368 CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSL----RAFQYDTNCSFRCAEGFMLR 423
Query: 367 HSVCIN----GKWN-PEVDCTEKREQFCPPPPQI-PNAQNMTTTVNYQDGEKVAVLCKEN 420
+ + G+W P C + Q P P + N + YQ + C E
Sbjct: 424 GADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQ--SVCSFTCNEG 481
Query: 421 YLLPEAKEIVC-KDGRWQSLPRCVESTAYCGPPPSINNGDTTSF-PLSVYPPGSTVTYRC 478
LL A + C G W S+P ++ C P S NG T PL ST + C
Sbjct: 482 LLLVGASVLQCLATGNWNSVPPECQAIP-CTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540
Query: 479 QSFYKLQGSVTVTC-RNKQWSE-PPRC 503
Y L G + C R+ +W++ PP C
Sbjct: 541 DEGYSLSGPERLDCTRSGRWTDSPPMC 567
Score = 67.4 bits (163), Expect = 3e-11
Identities = 65/265 (24%), Positives = 111/265 (41%), Gaps = 18/265 (6%)
Query: 70 ITCTEEG-WS-PTPKCLRMCSFPFVKNGHSE---SSGLIHLEGDT-VQIICNTGYSLQNN 123
+ C + G WS P P C + P H S L + DT C G+ L+
Sbjct: 366 LRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGA 425
Query: 124 EKNISCVERG-WSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIR 181
+ + C G W+ P P+C + + EA V+ +++ V F+C + L+
Sbjct: 426 DI-VRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLL 484
Query: 182 VGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRK-EEYGHNEVVEYDCNP 239
VG+ +QC G W+ P C Q C P NG + ++ + ++ C+
Sbjct: 485 VGASVLQCLATGNWNSVPPEC--QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542
Query: 240 NFIINGPKKIQCV-DGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVP--PYQHGVSVEVN 296
+ ++GP+++ C G WT P E +K C + E G + S + G + +
Sbjct: 543 GYSLSGPERLDCTRSGRWTDSPPMCEAIK-CPELFAPEQGSLDCSDTRGEFNVGSTCHFS 601
Query: 297 CRNEYAMIGNNMITC-INGIWTELP 320
C N + + G N + C +G W+ P
Sbjct: 602 CDNGFKLEGPNNVECTTSGRWSATP 626
Score = 66.6 bits (161), Expect = 6e-11
Identities = 61/237 (25%), Positives = 93/237 (39%), Gaps = 29/237 (12%)
Query: 109 TVQIICNTGYSLQNNEKNISCVERG-WS-TPPICSFTKGECHVPILEANVDAQPKKESYK 166
T Q IC+ GYSL E+ + C G W+ +PP+C K + ++D + +
Sbjct: 535 TCQFICDEGYSLSGPER-LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFN 593
Query: 167 VGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGP----PPQLSNGEVKE 221
VG FSC G ++V+C G WS PTCKG P P + G+
Sbjct: 594 VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
Query: 222 IRKEE---YGHNEVVEYDCNPNFIINGPKKIQC-VDGEWTTLPTCVEQVKTCGYIPELEY 277
+ +G N + CN F + G + C G+WT + VK C +
Sbjct: 654 YCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVK-CSEL----- 707
Query: 278 GYVQPSVP--------PYQHGVSVEVNCRNEYAMIGNNMITC-INGIW-TELPMCVA 324
+V + + +G +C + G+ C NG W T +P C A
Sbjct: 708 -HVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 72.0 bits (175), Expect = 1e-12
Identities = 90/350 (25%), Positives = 139/350 (39%), Gaps = 49/350 (14%)
Query: 1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFY-------Y 53
+L+LFS S++ V G C P D PFS V + FY Y
Sbjct: 5 VLILFS----SFLCHVAIAGRTCPKP-----------DDLPFSTVVPLKTFYEPGEEITY 49
Query: 54 SCEYNFVSPSKSFWTRITCTEEGWSP--TPKCL-RMCSFP-FVKNGHSESSGLIHLEGDT 109
SC+ +VS + + C G P T KC R+C F ++NG + + +T
Sbjct: 50 SCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEY--PNT 105
Query: 110 VQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES----- 164
+ CNTG+ L N + C E G +P + C P + + K S
Sbjct: 106 ISFSCNTGFYL-NGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNS 164
Query: 165 -YKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIR 223
Y+ D F C G+D++ C G P C+ +V+ C P + NG V
Sbjct: 165 LYR--DTAVFECLPQHAMFGNDTITCTTHGNWTKLPECR-EVK-CPFPSRPDNGFVNYPA 220
Query: 224 KEEYGHNEVVEYDCNPNFIINGPKKIQCVD-GEWTTLPTCVEQ----VKTCGYIPELEYG 278
K + + + C+ + ++GP++I+C G W+ +P+C VK + + E
Sbjct: 221 KPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERV 280
Query: 279 YVQPSVP-PYQHGVSVEVNCRN-EYAMIGNNMITCINGIWTELPMCVATH 326
+Q HG V C+N E CI+G E+P C H
Sbjct: 281 KIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGT-IEVPKCFKEH 329
Score = 36.6 bits (83), Expect = 0.064
Identities = 28/119 (23%), Positives = 51/119 (42%), Gaps = 8/119 (6%)
Query: 389 CPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEA-KEIVCK-DGRWQSLPRCVEST 446
CP P +P + + Y+ GE++ CK Y+ ++ +C G W ++ T
Sbjct: 23 CPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPI--NTLKCT 80
Query: 447 AYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNK-QWS-EPPRC 503
P I + YP +T+++ C + + L G+ + C + +WS E P C
Sbjct: 81 PRVCPFAGILENGAVRYTTFEYP--NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVC 137
>gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
Length = 490
Score = 71.6 bits (174), Expect = 2e-12
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 24/249 (9%)
Query: 84 LRMCSFPFV-KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVER-----GWSTP 137
L++C+ P + +NG SG + EG + C G+ L+ K + C++ GW
Sbjct: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
Query: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL-IR---VGSDSVQCYQFG 193
+ +C +P +E DA+ ++Y+ G+ L +C + IR + + C G
Sbjct: 113 DNSICVQEDCRIPQIE---DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
Query: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV 252
N P C+G C P SNG V + + V+ Y C P F ++G ++C+
Sbjct: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
Query: 253 DG-EWTTLPTCVEQVKTCGYIPELEYGYVQPSVPP---YQHGVSVEVNCRNEYAMIGN-N 307
W++ P ++ C P + +G P Y HG VE C Y++ +
Sbjct: 226 QNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYK 285
Query: 308 MITCINGIW 316
ITC G W
Sbjct: 286 YITCQYGEW 294
Score = 68.9 bits (167), Expect = 1e-11
Identities = 64/215 (29%), Positives = 99/215 (46%), Gaps = 35/215 (16%)
Query: 315 IWTELPMCVATHQL-------KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH 367
+W +L +C QL + C G+ SG F S R+ C D F+ +
Sbjct: 34 LWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG 93
Query: 368 S---VCI---NGK--WNPEVD--CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC 417
+ +C+ NG W P + C ++ + PQI +A+ T Y+ GEK+ + C
Sbjct: 94 ATKRLCLKHFNGTLGWIPSDNSICVQEDCRI----PQIEDAEIHNKT--YRHGEKLIITC 147
Query: 418 KENYLL--PEAKEIV--CKD-GRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSV-YPPG 471
E + + P+ +V C+D G W +LP C C P + +NG L +P G
Sbjct: 148 HEGFKIRYPDLHNMVSLCRDDGTWNNLPICQG----CLRPLASSNGYVNISELQTSFPVG 203
Query: 472 STVTYRCQSFYKLQGSVTVTC-RNKQW-SEPPRCL 504
+ ++YRC +KL GS + C +N W S PPRCL
Sbjct: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
Score = 66.2 bits (160), Expect = 7e-11
Identities = 61/237 (25%), Positives = 104/237 (43%), Gaps = 34/237 (14%)
Query: 44 QVPTGEVFY------YSCEYNFVSPSKSFWTRITCTEE-----GWSPTPKCLRM---CSF 89
+ P+G VF+ + C+ F T+ C + GW P+ + + C
Sbjct: 68 RTPSGGVFFEGSVARFHCQDGFKLKGA---TKRLCLKHFNGTLGWIPSDNSICVQEDCRI 124
Query: 90 PFVKNGHSESSGLIHLEGDTVQIICNTGYSLQ----NNEKNISCVERGWSTPPICSFTKG 145
P +++ + H G+ + I C+ G+ ++ +N ++ + W+ PIC
Sbjct: 125 PQIEDAEIHNKTYRH--GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQ---- 178
Query: 146 ECHVPILEAN--VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCK 202
C P+ +N V+ + S+ VG V+ + C GS ++C Q WS + P C
Sbjct: 179 GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
Query: 203 GQVRSCGPPPQLSNGE-VKEIRK-EEYGHNEVVEYDCNPNFIINGP-KKIQCVDGEW 256
+ C PP +S+G+ V R E Y H VVE+ C+P + + K I C GEW
Sbjct: 239 A-LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
Score = 46.2 bits (108), Expect = 8e-05
Identities = 59/283 (20%), Positives = 104/283 (36%), Gaps = 36/283 (12%)
Query: 256 WTTLPTCVEQVKTCGYIPEL---------EYGYVQPSVPPYQHGVSVEVNCRNEYAMIGN 306
W L C + G +L E G+ PS + G +C++ + + G
Sbjct: 35 WFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGA 94
Query: 307 NMITCI---NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIF 363
C+ NG +P + + C+I + ++ K + H ++ C + F
Sbjct: 95 TKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGF 151
Query: 364 RYRH-------SVCIN-GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTV--NYQDGEKV 413
+ R+ S+C + G WN C Q C P N + + ++ G +
Sbjct: 152 KIRYPDLHNMVSLCRDDGTWNNLPIC-----QGCLRPLASSNGYVNISELQTSFPVGTVI 206
Query: 414 AVLCKENYLLPEAKEIVCKDGR-WQSLPRCVESTAYCGPPPSINNGDTTSF--PLSVYPP 470
+ C + L + + C W S P + C PP +++GD P Y
Sbjct: 207 SYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNH 266
Query: 471 GSTVTYRCQSFYKLQGSVT-VTCRNKQWSEPPRCLDPCVVSEE 512
G+ V + C Y L +TC+ +W P C+ SE+
Sbjct: 267 GTVVEFYCDPGYSLTSDYKYITCQYGEWF--PSYQVYCIKSEQ 307
>gi|81295416 sushi domain containing 4 isoform b [Homo sapiens]
Length = 290
Score = 68.9 bits (167), Expect = 1e-11
Identities = 64/215 (29%), Positives = 99/215 (46%), Gaps = 35/215 (16%)
Query: 315 IWTELPMCVATHQL-------KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH 367
+W +L +C QL + C G+ SG F S R+ C D F+ +
Sbjct: 34 LWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG 93
Query: 368 S---VCI---NGK--WNPEVD--CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC 417
+ +C+ NG W P + C ++ + PQI +A+ T Y+ GEK+ + C
Sbjct: 94 ATKRLCLKHFNGTLGWIPSDNSICVQEDCRI----PQIEDAEIHNKT--YRHGEKLIITC 147
Query: 418 KENYLL--PEAKEIV--CKD-GRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSV-YPPG 471
E + + P+ +V C+D G W +LP C C P + +NG L +P G
Sbjct: 148 HEGFKIRYPDLHNMVSLCRDDGTWNNLPICQG----CLRPLASSNGYVNISELQTSFPVG 203
Query: 472 STVTYRCQSFYKLQGSVTVTC-RNKQW-SEPPRCL 504
+ ++YRC +KL GS + C +N W S PPRCL
Sbjct: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 20/189 (10%)
Query: 84 LRMCSFPFV-KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVER-----GWSTP 137
L++C+ P + +NG SG + EG + C G+ L+ K + C++ GW
Sbjct: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
Query: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL-IR---VGSDSVQCYQFG 193
+ +C +P +E DA+ ++Y+ G+ L +C + IR + + C G
Sbjct: 113 DNSICVQEDCRIPQIE---DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
Query: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV 252
N P C+G C P SNG V + + V+ Y C P F ++G ++C+
Sbjct: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
Query: 253 DG-EWTTLP 260
W++ P
Sbjct: 226 QNLIWSSSP 234
Score = 40.0 bits (92), Expect = 0.006
Identities = 49/194 (25%), Positives = 73/194 (37%), Gaps = 27/194 (13%)
Query: 147 CHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQ-----FGWSPNFPTC 201
C P + N P + G V +F C+ G+ C + GW P+ +
Sbjct: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
Query: 202 KGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-----DGEW 256
Q C P E EI + Y H E + C+ F I P V DG W
Sbjct: 117 CVQ-EDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
Query: 257 TTLPTCVEQVK----TCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI 312
LP C ++ + GY+ E +Q S P G + C + + G+ + C+
Sbjct: 172 NNLPICQGCLRPLASSNGYVNISE---LQTSFPV---GTVISYRCFPGFKLDGSAYLECL 225
Query: 313 -NGIWTEL-PMCVA 324
N IW+ P C+A
Sbjct: 226 QNLIWSSSPPRCLA 239
>gi|62912468 complement component 4 binding protein, beta chain
isoform 1 precursor [Homo sapiens]
Length = 252
Score = 63.2 bits (152), Expect = 6e-10
Identities = 45/154 (29%), Positives = 67/154 (43%), Gaps = 14/154 (9%)
Query: 113 ICNTGYSLQNNEKNISCVERGW-STPPICSFTKGECHVPILEANVDAQPKKES-YKVGDV 170
+C GY L + + W +T C G C P+L V+ + V D
Sbjct: 48 VCIKGYHLVGKKTLFCNASKEWDNTTTECRL--GHCPDPVL---VNGEFSSSGPVNVSDK 102
Query: 171 LKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGH 229
+ F C + I GS+ QC + W+P FP CK R C PP +G + +
Sbjct: 103 ITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKS--RDCDPPGNPVHGYFEG---NNFTL 157
Query: 230 NEVVEYDCNPNFIINGPKKIQCVDGEWTT-LPTC 262
+ Y C + + G ++ QCVDGEW++ LP C
Sbjct: 158 GSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 7/132 (5%)
Query: 73 TEEGWSPTPKC-LRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVE 131
++E + T +C L C P + NG SSG +++ D + +CN Y L+ + ++ +
Sbjct: 66 SKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLED 124
Query: 132 RGWSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCY 190
W+ P PIC +C P V + ++ +G + + C VG QC
Sbjct: 125 HTWAPPFPICK--SRDCDPP--GNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 180
Query: 191 QFGWSPNFPTCK 202
WS P CK
Sbjct: 181 DGEWSSALPVCK 192
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 5/117 (4%)
Query: 382 TEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPR 441
TE R CP P + + + VN D K+ +C ++Y+L + C + + P
Sbjct: 74 TECRLGHCPDPVLVNGEFSSSGPVNVSD--KITFMCNDHYILKGSNRSQCLEDHTWAPPF 131
Query: 442 CVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWS 498
+ + C PP + +G F + + GST++Y C+ Y L G C + +WS
Sbjct: 132 PICKSRDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWS 185
Score = 45.4 bits (106), Expect = 1e-04
Identities = 34/152 (22%), Positives = 65/152 (42%), Gaps = 9/152 (5%)
Query: 173 FSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNE 231
+ C K VG ++ C W C+ + C P P L NGE ++
Sbjct: 47 YVCIKGYHLVGKKTLFCNASKEWDNTTTECR--LGHC-PDPVLVNGEFSS--SGPVNVSD 101
Query: 232 VVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGV 291
+ + CN ++I+ G + QC++ P + + + C +GY + + + G
Sbjct: 102 KITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGN--NFTLGS 159
Query: 292 SVEVNCRNEYAMIGNNMITCINGIWTE-LPMC 322
++ C + Y ++G C++G W+ LP+C
Sbjct: 160 TISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 9/98 (9%)
Query: 350 NHNSRIRYRCSDIFRYR---HSVCINGK-WNPEVDCTEKREQFCPPPPQIPNAQNMTTTV 405
N + +I + C+D + + S C+ W P + R+ C PP
Sbjct: 98 NVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRD--CDPPGN--PVHGYFEGN 153
Query: 406 NYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQS-LPRC 442
N+ G ++ C++ Y L +E C DG W S LP C
Sbjct: 154 NFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 34.3 bits (77), Expect = 0.32
Identities = 26/114 (22%), Positives = 46/114 (40%), Gaps = 6/114 (5%)
Query: 393 PQIPNAQNMTTTVNYQDGEKVAV-LCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGP 451
P++P N +G+ + +C + Y L K + C + +C
Sbjct: 24 PELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPD 83
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
P +N ++S P++V +T+ C Y L+GS C + W+ P P C
Sbjct: 84 PVLVNGEFSSSGPVNV---SDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 134
>gi|62912466 complement component 4 binding protein, beta chain
isoform 2 precursor [Homo sapiens]
Length = 251
Score = 63.2 bits (152), Expect = 6e-10
Identities = 45/154 (29%), Positives = 67/154 (43%), Gaps = 14/154 (9%)
Query: 113 ICNTGYSLQNNEKNISCVERGW-STPPICSFTKGECHVPILEANVDAQPKKES-YKVGDV 170
+C GY L + + W +T C G C P+L V+ + V D
Sbjct: 47 VCIKGYHLVGKKTLFCNASKEWDNTTTECRL--GHCPDPVL---VNGEFSSSGPVNVSDK 101
Query: 171 LKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGH 229
+ F C + I GS+ QC + W+P FP CK R C PP +G + +
Sbjct: 102 ITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKS--RDCDPPGNPVHGYFEG---NNFTL 156
Query: 230 NEVVEYDCNPNFIINGPKKIQCVDGEWTT-LPTC 262
+ Y C + + G ++ QCVDGEW++ LP C
Sbjct: 157 GSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 190
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 7/132 (5%)
Query: 73 TEEGWSPTPKC-LRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVE 131
++E + T +C L C P + NG SSG +++ D + +CN Y L+ + ++ +
Sbjct: 65 SKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLED 123
Query: 132 RGWSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCY 190
W+ P PIC +C P V + ++ +G + + C VG QC
Sbjct: 124 HTWAPPFPICK--SRDCDPP--GNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 179
Query: 191 QFGWSPNFPTCK 202
WS P CK
Sbjct: 180 DGEWSSALPVCK 191
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 5/117 (4%)
Query: 382 TEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPR 441
TE R CP P + + + VN D K+ +C ++Y+L + C + + P
Sbjct: 73 TECRLGHCPDPVLVNGEFSSSGPVNVSD--KITFMCNDHYILKGSNRSQCLEDHTWAPPF 130
Query: 442 CVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWS 498
+ + C PP + +G F + + GST++Y C+ Y L G C + +WS
Sbjct: 131 PICKSRDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWS 184
Score = 45.4 bits (106), Expect = 1e-04
Identities = 34/152 (22%), Positives = 65/152 (42%), Gaps = 9/152 (5%)
Query: 173 FSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNE 231
+ C K VG ++ C W C+ + C P P L NGE ++
Sbjct: 46 YVCIKGYHLVGKKTLFCNASKEWDNTTTECR--LGHC-PDPVLVNGEFSS--SGPVNVSD 100
Query: 232 VVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGV 291
+ + CN ++I+ G + QC++ P + + + C +GY + + + G
Sbjct: 101 KITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGN--NFTLGS 158
Query: 292 SVEVNCRNEYAMIGNNMITCINGIWTE-LPMC 322
++ C + Y ++G C++G W+ LP+C
Sbjct: 159 TISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 190
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 9/98 (9%)
Query: 350 NHNSRIRYRCSDIFRYR---HSVCINGK-WNPEVDCTEKREQFCPPPPQIPNAQNMTTTV 405
N + +I + C+D + + S C+ W P + R+ C PP
Sbjct: 97 NVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRD--CDPPGN--PVHGYFEGN 152
Query: 406 NYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQS-LPRC 442
N+ G ++ C++ Y L +E C DG W S LP C
Sbjct: 153 NFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 190
Score = 34.3 bits (77), Expect = 0.32
Identities = 26/114 (22%), Positives = 46/114 (40%), Gaps = 6/114 (5%)
Query: 393 PQIPNAQNMTTTVNYQDGEKVAV-LCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGP 451
P++P N +G+ + +C + Y L K + C + +C
Sbjct: 23 PELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPD 82
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
P +N ++S P++V +T+ C Y L+GS C + W+ P P C
Sbjct: 83 PVLVNGEFSSSGPVNV---SDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 133
>gi|62912464 complement component 4 binding protein, beta chain
isoform 1 precursor [Homo sapiens]
Length = 252
Score = 63.2 bits (152), Expect = 6e-10
Identities = 45/154 (29%), Positives = 67/154 (43%), Gaps = 14/154 (9%)
Query: 113 ICNTGYSLQNNEKNISCVERGW-STPPICSFTKGECHVPILEANVDAQPKKES-YKVGDV 170
+C GY L + + W +T C G C P+L V+ + V D
Sbjct: 48 VCIKGYHLVGKKTLFCNASKEWDNTTTECRL--GHCPDPVL---VNGEFSSSGPVNVSDK 102
Query: 171 LKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGH 229
+ F C + I GS+ QC + W+P FP CK R C PP +G + +
Sbjct: 103 ITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKS--RDCDPPGNPVHGYFEG---NNFTL 157
Query: 230 NEVVEYDCNPNFIINGPKKIQCVDGEWTT-LPTC 262
+ Y C + + G ++ QCVDGEW++ LP C
Sbjct: 158 GSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 7/132 (5%)
Query: 73 TEEGWSPTPKC-LRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVE 131
++E + T +C L C P + NG SSG +++ D + +CN Y L+ + ++ +
Sbjct: 66 SKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLED 124
Query: 132 RGWSTP-PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCY 190
W+ P PIC +C P V + ++ +G + + C VG QC
Sbjct: 125 HTWAPPFPICK--SRDCDPP--GNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 180
Query: 191 QFGWSPNFPTCK 202
WS P CK
Sbjct: 181 DGEWSSALPVCK 192
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 5/117 (4%)
Query: 382 TEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPR 441
TE R CP P + + + VN D K+ +C ++Y+L + C + + P
Sbjct: 74 TECRLGHCPDPVLVNGEFSSSGPVNVSD--KITFMCNDHYILKGSNRSQCLEDHTWAPPF 131
Query: 442 CVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWS 498
+ + C PP + +G F + + GST++Y C+ Y L G C + +WS
Sbjct: 132 PICKSRDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWS 185
Score = 45.4 bits (106), Expect = 1e-04
Identities = 34/152 (22%), Positives = 65/152 (42%), Gaps = 9/152 (5%)
Query: 173 FSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNE 231
+ C K VG ++ C W C+ + C P P L NGE ++
Sbjct: 47 YVCIKGYHLVGKKTLFCNASKEWDNTTTECR--LGHC-PDPVLVNGEFSS--SGPVNVSD 101
Query: 232 VVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGV 291
+ + CN ++I+ G + QC++ P + + + C +GY + + + G
Sbjct: 102 KITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGN--NFTLGS 159
Query: 292 SVEVNCRNEYAMIGNNMITCINGIWTE-LPMC 322
++ C + Y ++G C++G W+ LP+C
Sbjct: 160 TISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 35.8 bits (81), Expect = 0.11
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 9/98 (9%)
Query: 350 NHNSRIRYRCSDIFRYR---HSVCINGK-WNPEVDCTEKREQFCPPPPQIPNAQNMTTTV 405
N + +I + C+D + + S C+ W P + R+ C PP
Sbjct: 98 NVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRD--CDPPGN--PVHGYFEGN 153
Query: 406 NYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQS-LPRC 442
N+ G ++ C++ Y L +E C DG W S LP C
Sbjct: 154 NFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVC 191
Score = 34.3 bits (77), Expect = 0.32
Identities = 26/114 (22%), Positives = 46/114 (40%), Gaps = 6/114 (5%)
Query: 393 PQIPNAQNMTTTVNYQDGEKVAV-LCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGP 451
P++P N +G+ + +C + Y L K + C + +C
Sbjct: 24 PELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPD 83
Query: 452 PPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTC-RNKQWSEP-PRC 503
P +N ++S P++V +T+ C Y L+GS C + W+ P P C
Sbjct: 84 PVLVNGEFSSSGPVNV---SDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPIC 134
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,293,363
Number of Sequences: 37866
Number of extensions: 1452856
Number of successful extensions: 4431
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 2963
Number of HSP's gapped (non-prelim): 678
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.