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Search of human proteins with 134948558
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
(2062 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 4096 0.0
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 4034 0.0
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 523 e-148
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 133 2e-30
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 128 5e-29
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 111 8e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 110 1e-23
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 109 2e-23
gi|87299628 biorientation of chromosomes in cell division 1-like... 104 1e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 103 2e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 103 2e-21
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 103 2e-21
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 103 2e-21
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 103 2e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 102 3e-21
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 102 4e-21
gi|148746195 trichohyalin [Homo sapiens] 102 4e-21
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 101 7e-21
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 100 1e-20
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 100 2e-20
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 100 3e-20
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 99 3e-20
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 99 3e-20
gi|221219020 NYD-SP11 protein [Homo sapiens] 99 6e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 99 6e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 99 6e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 98 7e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 98 7e-20
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 4096 bits (10624), Expect = 0.0
Identities = 2062/2062 (100%), Positives = 2062/2062 (100%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS
Sbjct: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
Query: 121 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK
Sbjct: 121 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
Query: 181 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA
Sbjct: 181 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
Query: 241 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL
Sbjct: 241 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
Query: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE
Sbjct: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
Query: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR
Sbjct: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
Query: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN
Sbjct: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
Query: 481 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST
Sbjct: 481 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
Query: 541 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC
Sbjct: 541 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
Query: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER
Sbjct: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
Query: 661 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL
Sbjct: 661 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
Query: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
Query: 781 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT
Sbjct: 781 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
Query: 841 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR
Sbjct: 841 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
Query: 901 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK
Sbjct: 901 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
Query: 961 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK
Sbjct: 961 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
Query: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF
Sbjct: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
Query: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR
Sbjct: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
Query: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS
Sbjct: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
Query: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE
Sbjct: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
Query: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
Sbjct: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
Query: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK
Sbjct: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
Query: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN
Sbjct: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
Query: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS
Sbjct: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
Query: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF
Sbjct: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
Query: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE
Sbjct: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
Query: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL
Sbjct: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
Query: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA
Sbjct: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
Query: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP
Sbjct: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
Query: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA
Sbjct: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
Query: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE
Sbjct: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
Query: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR
Sbjct: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
Query: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI
Sbjct: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
Query: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
YEIQEFYVPLVDVNDDFELTPI
Sbjct: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 4034 bits (10462), Expect = 0.0
Identities = 2039/2062 (98%), Positives = 2039/2062 (98%), Gaps = 23/2062 (1%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
Query: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
KLPFTISPSRNEERDSDT EKEGPEKKKTKKEAGNKKS
Sbjct: 61 KLPFTISPSRNEERDSDT-----------------------EKEGPEKKKTKKEAGNKKS 97
Query: 121 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK
Sbjct: 98 TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 157
Query: 181 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA
Sbjct: 158 RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 217
Query: 241 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL
Sbjct: 218 GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 277
Query: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE
Sbjct: 278 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 337
Query: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR
Sbjct: 338 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 397
Query: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN
Sbjct: 398 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 457
Query: 481 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST
Sbjct: 458 KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 517
Query: 541 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC
Sbjct: 518 GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 577
Query: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER
Sbjct: 578 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 637
Query: 661 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL
Sbjct: 638 EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 697
Query: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD
Sbjct: 698 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 757
Query: 781 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT
Sbjct: 758 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 817
Query: 841 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR
Sbjct: 818 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 877
Query: 901 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK
Sbjct: 878 EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 937
Query: 961 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK
Sbjct: 938 KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 997
Query: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF
Sbjct: 998 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1057
Query: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR
Sbjct: 1058 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1117
Query: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS
Sbjct: 1118 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1177
Query: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE
Sbjct: 1178 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1237
Query: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
Sbjct: 1238 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1297
Query: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK
Sbjct: 1298 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1357
Query: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN
Sbjct: 1358 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1417
Query: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS
Sbjct: 1418 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1477
Query: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF
Sbjct: 1478 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1537
Query: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE
Sbjct: 1538 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1597
Query: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL
Sbjct: 1598 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1657
Query: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA
Sbjct: 1658 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1717
Query: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP
Sbjct: 1718 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1777
Query: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA
Sbjct: 1778 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1837
Query: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE
Sbjct: 1838 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1897
Query: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR
Sbjct: 1898 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1957
Query: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI
Sbjct: 1958 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2017
Query: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
YEIQEFYVPLVDVNDDFELTPI
Sbjct: 2018 YEIQEFYVPLVDVNDDFELTPI 2039
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 523 bits (1346), Expect = e-148
Identities = 466/1437 (32%), Positives = 697/1437 (48%), Gaps = 225/1437 (15%)
Query: 1 MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
MPK G K Q E S+MVEK G+K KDK+ S +KTPK+ER D KE++E++S KR
Sbjct: 1 MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKV-SLTKTPKLERGDGGKEVRERAS-KR 58
Query: 61 KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
KLPFT + E++DSDT EK+GPE+K+ KKE +K+
Sbjct: 59 KLPFTAG-ANGEQKDSDT-----------------------EKQGPERKRIKKEPVTRKA 94
Query: 121 TPV------SILFGYPLSERKQMALLMQMTARD--NSP-DSTPNHPSQTTPAQKKTPSSS 171
+ I GYPLSER+Q+ALLMQMTA + NSP D+TP HPSQ+T QK TP+S+
Sbjct: 95 GLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSA 154
Query: 172 SRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYY 231
S+ KDKVNKRNERGET LH AAIRGD +++KELIS GA+VNVKDFAGWT LHEACN GYY
Sbjct: 155 SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214
Query: 232 DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
DVAK L+AAGA+VNT+GLDDDTPLHD+A++GH +VKLLLR+GGNP Q+N+ GE P+ VA
Sbjct: 215 DVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA 274
Query: 292 ETEELELLLKREVPLSDDDESYTDS---EEAQSVNP-SSVD-ENIDSETEKDSLICESKQ 346
+ + LL + + +ES T+S E+A S P SSVD N DSE EK L ++K
Sbjct: 275 NSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEK-GLKHKAKN 333
Query: 347 ILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
P K P DEYEF +DD+++ +DD+H+L+K+ RKE + + + K E
Sbjct: 334 PEPQKATAP-VKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFIS--IPKMEVKS 390
Query: 407 YPKSFKSKKQKPSRVLYSSTESSDEEAL---QNKKISTSC-SVIPETSNSDMQTKKEYVV 462
Y K+ +K S + S T ++ ++ +K+ S +++P + + K
Sbjct: 391 YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK---- 446
Query: 463 SGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 522
+ K+K KVK+K K + K +E + K+ + ++ + + +G D + G +
Sbjct: 447 --QQKEKNKVKKKRKKETKGREVRFGKRSDKFC-SSESESESSESGEDDRDSLGSSGCLK 503
Query: 523 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT--------KTCLSPGSSEM 574
S D SL +S + H ++KQ+ +HT KT SP SE+
Sbjct: 504 GSPLVLKDPSL-FSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEV 562
Query: 575 SLQPDLVRYDNT-ESEFLPESSSVKSCKH-KEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
S D R T ES++ E SSV+S K +++ +H+K L E SP
Sbjct: 563 SSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASL-----------SEKKSPF 611
Query: 633 FENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHK----KEIEGEKEKYKTKDSAKELQRS 688
+++ + K+DKEGK +KKHK KHK + KEK + +E++ + Y+ +DS ++ ++
Sbjct: 612 LSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKA 671
Query: 689 VEFDREFWKENFFK-SDETEDLFLNMEHES-LTLEKKSKLEKNIKDDKSTKEKHVSKERN 746
+ + + EN K D F E S + LE+K L K+ K K K+ + R+
Sbjct: 672 ILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRS 731
Query: 747 FKEERDKIKKE------SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 800
F+EE+D+ K EKS +EEK++ KEER+ D+ S+
Sbjct: 732 FREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN----------D 781
Query: 801 LVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHE-HKSEKDK 857
L E +I EK EK KE KEK +K +E E + F + + K ++D+
Sbjct: 782 LKEDKISKEK-EKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR 840
Query: 858 --LDLSECVDKIKEKDKLYSHHTE--------------KCHKEG--EKSKNTAAIKKTDD 899
DLS+ K +D S T+ + KE E+ +++ A +K D
Sbjct: 841 WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900
Query: 900 RE-----KSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK------ 948
RE K R+ +D+ +K K + E+H +S +L EK K+ +++E + K
Sbjct: 901 REPFFRKKDRDYLDKNSEKRKEQTEKH--KSVPGYLSEKDKKRRESAEAGRDRKDALESC 958
Query: 949 -------GKNKEKDRE-----------LDKKEKSRDKESINITNSKHIQEEKKSSIVDGN 990
K +E RE DK + K +E++K D
Sbjct: 959 KERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKE 1018
Query: 991 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDR-YKE----RDKH-----KDKIQIN 1040
+ + KP KEK+ D+ EK +KDK+ D+ +KE ++KH KDK +
Sbjct: 1019 RKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKA 1078
Query: 1041 SLLKLKSEADKPKP-----KSSPASKDTRPKEKRLVNDDLMQTSFE-----------RML 1084
SL + K + +K P S D + KEK D+ E +M
Sbjct: 1079 SLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138
Query: 1085 SLKDL-------EIEQW--------HKK-----HKEKIKQKE-KERLRNRNCLELKIKDK 1123
DL E E+ H+K H E+ K KE ++R ++R + K
Sbjct: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
Query: 1124 EKTKHTPTESKNKELT---RSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSF 1180
EK E K+KE T + + + T++K+ K + +++ K
Sbjct: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
Query: 1181 VSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSD----FMLE 1236
SD S+ K S+ + + E++ H EY D
Sbjct: 1259 KSDKE-----HSKERKSSRSADAEKSLLEKLEEEALH----------EYREDSNDKISEV 1303
Query: 1237 SSESQMSFSQSP----FLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSS 1289
SS+S Q P FL ++ + + + A LPE++K +R S+S + S
Sbjct: 1304 SSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
Score = 452 bits (1162), Expect = e-126
Identities = 231/337 (68%), Positives = 275/337 (81%), Gaps = 10/337 (2%)
Query: 1730 QIPQRMTRNKANTMANQSKQILASCTLLSEKD---SESSSPRGRIRLTEDDDPQIHHPRK 1786
+IPQRMTRN+A +ANQSKQ SEK+ + + R + R +EDDD Q HPRK
Sbjct: 2331 EIPQRMTRNRAQMLANQSKQGPPP----SEKECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386
Query: 1787 RKVSRVPQPVQ--VSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRK 1844
R+ R Q +Q ++ S Q +E QQ+LAAIVD++KLD I+PY S+RANPYFEYL IRK
Sbjct: 2387 RRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRK 2446
Query: 1845 KIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFR 1904
KIEEKRK+LC + PQAPQ Y EYVT+ GSYLLDG PLSK+ IP I PPPSL++PLKELFR
Sbjct: 2447 KIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFR 2506
Query: 1905 QQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNV 1964
QQE VR KLRLQHSIEREKLIVS EQE+LRVH RAART+ANQ +PFSACT+LLD+EVYN+
Sbjct: 2507 QQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNM 2566
Query: 1965 PLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQ 2024
PL+SQ D++K SVRDRFNARQF+SWLQDVDDK+D++KTCLLMRQQHEAAALNAVQR+EWQ
Sbjct: 2567 PLESQGDENK-SVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQ 2625
Query: 2025 LKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTP 2061
LK+QELDPA +KS+ + E+ FYVP+VDVNDDF L P
Sbjct: 2626 LKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLP 2662
Score = 181 bits (460), Expect = 5e-45
Identities = 258/1123 (22%), Positives = 454/1123 (40%), Gaps = 184/1123 (16%)
Query: 289 DVAETEELELLLKREVPLSDDDESYTDSEEAQSVN-PSSVDENIDSET-----EKDSLIC 342
D + E E LK + P + Y + + +S + PS +++ D + EK+ +
Sbjct: 737 DRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK 796
Query: 343 ESKQILPSKTPL--PSALDEY----EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 396
E K+ L + SA DEY +F +++D + + L +QR + +
Sbjct: 797 EDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFS--------LSDDQRDRWFSDLSDS 848
Query: 397 HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS------------ 444
K E ++ + K V E+ E++ + ++ S +
Sbjct: 849 SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908
Query: 445 ----VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN--QELKQEKEGKENT 498
+ + QT+K V G +K K +R+ +++++ + K+ ++G+
Sbjct: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968
Query: 499 RITNLTV--NTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 556
+ G + K + +G+F K P + H + K K K+ T
Sbjct: 969 EEAHREELKECGCESGFKDKSDGDFGKGLEPWER-----HHPAREKEKKDGPDKERKEKT 1023
Query: 557 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 616
++ K+ S + + ++ + EF K K K K H KD +
Sbjct: 1024 KPERYKEKS-----SDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK- 1077
Query: 617 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 676
K K E P + D + KK DK+GK + E E + G K
Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKM 1137
Query: 677 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
A +L R+ + + +E + + + H + ++ + +K+ +
Sbjct: 1138 ---GEASDLPRT---------DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRR 1185
Query: 737 KEKHVS------KERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGM 790
K++ + KE+ F++ ++K KES + +++ K +R ++ + +D +
Sbjct: 1186 KDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK------DRASVDSTQDKKNKQKLP 1239
Query: 791 SAIEESIGLHLVEKEIDIEKQEKHIKE-SKEKPEKRSQIKEKDI-EKMERKTFEKEKKIK 848
E+ H E + + +EK KE SKE+ RS EK + EK+E + + ++
Sbjct: 1240 EKAEKK---HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296
Query: 849 HEHKSE----------------------------KDKLDLSECV-DKIKEKDK-LYSHHT 878
++ SE DK S C+ +K+KEK++ +S +
Sbjct: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356
Query: 879 EKCHKEGEKSKNTAAIKKT---DDREKSREKMDRKHDKE-------------KPEKERHL 922
K + E++K A KK D +E K +++K+ K + E L
Sbjct: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
Query: 923 AESKEKHLMEKKNKQSDNSEYSKS----------------EKGKNKEKDREL--DKKEKS 964
++ E EKK+K E SK ++ K +EK RE D+KE+
Sbjct: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERH 1476
Query: 965 RDKESINITNS------KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
RD+ + + +H ++E+K + D + P LK+K++DE + D K K+
Sbjct: 1477 RDRHADGLLRHHRDELLRHHRDEQKPATRD----KDSPPRVLKDKSRDEGPRLGDAKLKE 1532
Query: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
K ++ K +K+ + DK P P KD RP+EK L + DLM T
Sbjct: 1533 KFKDGAEKEK-----------GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMT 1581
Query: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1138
SFERMLS KDLEIE+ HK+HKE++KQ EK R R+ + K KEK K K
Sbjct: 1582 SFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD-----PKLKEKAKPADDGRKKGLD 1636
Query: 1139 TRSKSSEVTDAYTKEKQPKD------AVSNR---SQSVDTKNVMTLGKSSFVSDNSLNRS 1189
+K D K+K+ K+ A N+ + D+K+ + V L S
Sbjct: 1637 IPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEV----LPAS 1692
Query: 1190 PRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPF 1249
PR + +P S++S S E+ HT TP + +D + + ++SQ S
Sbjct: 1693 PRPDQSRPTGVPTPTSVLSCPSYEEVMHTP-RTPSCSADDYADLVFDCADSQHSTPVPTA 1751
Query: 1250 LSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVE 1292
+ A SP+ +R + + L E A LST+ RS SV+
Sbjct: 1752 PTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVD 1794
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 133 bits (334), Expect = 2e-30
Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 1/153 (0%)
Query: 149 SPDSTPNHPSQTTPAQ-KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISL 207
SP + P+ S ++ + +PS+ + KRN RGET LH+A+I+GD+ V+ L+
Sbjct: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450
Query: 208 GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIV 267
G++ NVKD AGWTPLHEACN G+ V ++L+ A VNT G +D+PLHD+A +GH DIV
Sbjct: 451 GSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIV 510
Query: 268 KLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
KLLL +G + N G RPVD + E ++ LL
Sbjct: 511 KLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 147 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 267 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 327 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 387 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 445 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 505 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 559 KQEHTKTCLS 568
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 147 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 267 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 327 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 387 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 445 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 505 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 559 KQEHTKTCLS 568
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 128 bits (322), Expect = 5e-29
Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)
Query: 147 DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
DN N + +K+ + ++NKRN RGE+ LH+A RG++ VK LI
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176
Query: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
GA+VN+ D AGWTPLHEA N G D+ L+ AGA VN + +D PLHD+ ++ H
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236
Query: 267 VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
++LL++G NP Q ++ + +D A+ E+++ LL+ SY E
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279
Query: 327 VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
+ E D+++ E + SK D+ K ID + +E+
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322
Query: 387 KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
+E+ + + +EK Y F+ + + E E+ L+ KKI +
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375
Query: 445 VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
+ D+ K+Y VS E + G ++ +L N +++ + +K+ K + +I N
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433
Query: 505 VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
T L C K ++ TSL +L H +G S + E Q T
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493
Query: 559 KQEHTKTCLS 568
++T CL+
Sbjct: 1494 YSQNTNICLN 1503
Score = 104 bits (260), Expect = 8e-22
Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
+K S ++K KVNK RN GE ++ AA+ D V I G NVN
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519
Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
+AGWT LHEA G+Y A L+ GADVN +GL TPLHD+ +GH + +LLL +G
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579
Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
+P N G+ +D A+ ++ LL+R +P + S + S++P +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 111 bits (277), Expect = 8e-24
Identities = 116/591 (19%), Positives = 273/591 (46%), Gaps = 52/591 (8%)
Query: 603 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTL---------KKMDKEGKTLKKH 653
K+ ++ Q+ L EKS ++ ++ E + L ++M ++ + L++
Sbjct: 225 KKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 284
Query: 654 KLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNM 713
+ K +++E++ ++E +++ K ++ +++ R + RE KE +
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE--------------L 330
Query: 714 EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE 773
+ L ++ +L + + + +EK +E +E+ +K+ ++ E+ + +EK +E+
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
Query: 774 R----ENIPTDKDSEFTSLGMSAIEESIGLHLVEK---EIDIEKQEKHIKESKEKPEKRS 826
+ E ++D E+ VEK E +++QEK ++ +EK ++
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 827 QIKEKD---------IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 877
+I+E++ + + E K ++E+ + + + E + L E +K+ E++K+
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM-QEQ 509
Query: 878 TEKCHKEGEKSKNTAAI----KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEK 933
EK ++ EK ++ + KK +EK RE+ D+ ++E+ +++ ++ MEK
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 934 KNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
K ++ + + + EK + +E+ RE +KK + ++ QEEK + Q
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 994 HEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS----EA 1049
EK +EK ++ K + +EK + + + KE+ +K+Q ++ + E
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 1050 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK--KHKEKIKQKEK 1107
+K + K+ K T +EK + ++ M+ ++M +++ EQ K + +EK++++E+
Sbjct: 690 EKMEKKTQEQEKKTWDQEK-MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 1108 ERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1158
E + + + + + P E K K K E + +E++ +D
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLP-EQKEKLWEHEKMQEQEKIWEQEEKMRD 798
Score = 100 bits (250), Expect = 1e-20
Identities = 105/523 (20%), Positives = 253/523 (48%), Gaps = 56/523 (10%)
Query: 641 KKMDKEGKTLKKHKLKHKEREK-----EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREF 695
++M ++ + L++ + + +E+EK EK ++E + ++++ KT+D +++Q + E
Sbjct: 397 ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ-----EEER 451
Query: 696 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI--KDDKSTKEKHVSKERNFKEERDK 753
+E K E E+ E EK K E+N+ +++K +++ + +++ E++K
Sbjct: 452 IREREKKMREEEETMREQE------EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 754 IKKESEKSF-REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 812
++++ EK + +EEKI+D +E M E+ + ++ + +QE
Sbjct: 506 MQEQEEKIWEQEEKIRDQEE-----------------MWGQEKKMW-----RQEKMREQE 543
Query: 813 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 872
+ E +EK + Q E+ME+KT E+EKK + + +++ + E K++E+++
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 873 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 932
+ EK ++ EK + K + EK +E+ ++ ++E+ E+ +++ L E
Sbjct: 604 MMREQEEKMQEQEEKMQEQEE-KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 933 KKNKQSDNSEYSKSEK-GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 991
+K K ++ + + EK + +EK E +K EK ++ + + ++EE+ S+ + K
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE--SMREREK 720
Query: 992 AQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
E+ ++E ++E ++ + K ++++++ ++ ++ + ++K+ L + E
Sbjct: 721 KMREEEEMMRE--QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERML----SLKDLEIEQWHKKHK-----EKI 1102
K K +EK ++ M+ E+M ++ E + W ++ K EK+
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 1103 KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
+E++ +E K++ +E+ E + + + E
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881
Score = 93.2 bits (230), Expect = 2e-18
Identities = 134/674 (19%), Positives = 285/674 (42%), Gaps = 99/674 (14%)
Query: 358 LDEYEFKDDDDEEINKMIDDRHILRKEQR--KENEPEAEKTHLFAKQEKAFYPKSFKSKK 415
L E E K + EE KM LR++++ +E E E + +QE+ + K +
Sbjct: 302 LREQEGKMREQEE--KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 416 QKPSRVLYSSTESSDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVK 473
Q+ EE L Q K++ M+ ++E + + + + K +
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQM--------REQEQKMRDQEERMWEQDERLREKEE 411
Query: 474 RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR---KSFSPKDD 530
R + + ++ +++++EK+ +E + T D EK +EE R K +++
Sbjct: 412 RMREQEKMWEQVEKMREEKKMQEQEKKTR-------DQEEKMQEEERIREREKKMREEEE 464
Query: 531 TSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEF 590
T K K + E++ +Q+ + +Q + E +
Sbjct: 465 TMRE----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 591 LPESS---SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
+ K +EK + Q+D E EK ++D++ + K ++E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK----MRDQEQKMWDQEERMEKKTQEQEK 576
Query: 648 KTL-KKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 706
KT ++ K++ +ER +E+ KK E E+ + ++ +E + ++ E E K E
Sbjct: 577 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 707 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 766
E+ E + E+K ++ + + K +H + E++K++++ EK + +EK
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ-----EQEKMQEQEEKIWEQEK 691
Query: 767 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PE 823
++ +E+E D++ EES+ E+E + ++E+ ++E +EK E
Sbjct: 692 MEKKTQEQEKKTWDQEK-------MREEESMR----EREKKMREEEEMMREQEEKMQEQE 740
Query: 824 KRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
++ Q +E+++ + E K +E+E+K+ + + + K L E +K++E++K++ EK
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH-EKMQEQEKIWEQE-EKMRD 798
Query: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 943
+ EK + EKM + +K + ++E+ + ++ E+K + +
Sbjct: 799 QEEKMRG------------QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
Query: 944 SKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK 1003
+ EK + K + +E EK R++E EK +EK
Sbjct: 847 GQEEKMEEKMQGQE----EKMREQE--------------------------EKMRGQEEK 876
Query: 1004 TKDEPLKTPDGKEK 1017
+++ K +EK
Sbjct: 877 MREQEEKMRGQEEK 890
Score = 90.5 bits (223), Expect = 2e-17
Identities = 96/477 (20%), Positives = 216/477 (45%), Gaps = 76/477 (15%)
Query: 664 KHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEH 715
+HKK +E K +D+ EL R+ + E K+N E ++ LN++
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 716 ESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERE 775
LE+ L ++ + + +E+ +E +E+ KI+K+ EK +R+E+
Sbjct: 251 LKRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--------- 300
Query: 776 NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEK 835
L E+E + +QE E + EKR + +EK++ +
Sbjct: 301 ------------------------RLREQEGKMREQE----EKMWRQEKRLREQEKELRE 332
Query: 836 MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIK 895
E++ E+++ + E + ++ + + E +K++E+++ E+ E EK K
Sbjct: 333 QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW-EQEKQMREQEQK 391
Query: 896 KTDDREKSREKMDRKHDKEKPEKERH-LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
D E+ E+ +R +KE+ +E+ + E EK EKK ++ + + EK + +E+
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 955 DRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL 1009
RE +KK E R++E +++ E+++ + ++ L +EK +++
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 1010 KTPDGKEKDK------------------KDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
K + +EK + ++++ +++ +K +D+ Q K+ + ++
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQEER 566
Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
+ K+ K T +E+++ ++ M+ ++M +++ EQ K +++ K +E+E
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Score = 81.6 bits (200), Expect = 7e-15
Identities = 123/598 (20%), Positives = 244/598 (40%), Gaps = 68/598 (11%)
Query: 279 QANKHGERPVDVAETEEL-----ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
Q K E+ + E EE E L ++E + + ++ D EE + E +
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 334 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ--RKENEP 391
E++ + + +++ K + E E K D EE KM ++ I +E+ R+E E
Sbjct: 413 MREQEKMWEQVEKMREEKK-----MQEQEKKTRDQEE--KMQEEERIREREKKMREEEET 465
Query: 392 EAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSN 451
E+ KQE+ + + K +Q+ ++ Q +KI I +
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
Query: 452 SDMQTKKEYVVSGEHKQKGKV---KRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG 508
Q KK + +Q+ ++ + K+++Q + +QE + EK+ +E + T
Sbjct: 526 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT------- 578
Query: 509 LDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLS 568
D EK REE R+ K + + +Q ++++ K
Sbjct: 579 WDQEEKMREEERMRER----------------EKKMREEEEMMREQEEKMQEQEEK---- 618
Query: 569 PGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDED 628
M Q + + E E + K + +EK Q++ E K K +
Sbjct: 619 -----MQEQEEKM----WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 629 HSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 688
H E K ++E K ++ K++ K +E+EK ++EK + ++S +E ++
Sbjct: 670 HEKMQEQE----KMQEQEEKIWEQEKMEKKTQEQEKKT----WDQEKMREEESMREREKK 721
Query: 689 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKK--SKLEKNIKDDKSTKEKHVSKERN 746
+ + E +E K E E+ E E E+K + EK + + ++K E
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 747 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 806
+E++KI ++ EK +E+ +EE+ +K E+ G +E
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG-----QEE 836
Query: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 864
+ QE+ + +EK E++ Q +E+ + + E K +E+K++ + + + + + CV
Sbjct: 837 KMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCV 894
Score = 53.1 bits (126), Expect = 3e-06
Identities = 64/332 (19%), Positives = 153/332 (46%), Gaps = 51/332 (15%)
Query: 809 EKQEKHIKE-SKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHKSEKDKLDLSECVD 865
+K +++I+E +KE+ ++ I E++++K E ++K+ +SEK ++ L+
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLN---- 247
Query: 866 KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAES 925
+KE + + + ++ ++ + +K+ ++ +K ++ER
Sbjct: 248 -VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER----- 301
Query: 926 KEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSS 985
L E++ K + E ++ + +E+++EL ++EK + K ++E+++
Sbjct: 302 ----LREQEGKMREQEEKMWRQEKRLREQEKELREQEK-------ELREQKELREQEEQM 350
Query: 986 IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKL 1045
+ Q EK +EK +++ ++ + R +ER ++K K+
Sbjct: 351 -----QEQEEKMWEQEEKMREQ-------------EEKMWRQEERLWEQEKQMREQEQKM 392
Query: 1046 KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQK 1105
+ + ++ + + R KE+R+ + M E+M K ++ EQ K ++ K +
Sbjct: 393 RDQEERMWEQ----DERLREKEERMREQEKMWEQVEKMREEKKMQ-EQEKKTRDQEEKMQ 447
Query: 1106 EKERLRNRNCLELKIKDKEKTKHTPTESKNKE 1137
E+ER+R R E K++++E+T E K+
Sbjct: 448 EEERIRER---EKKMREEEETMREQEEKMQKQ 476
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 110 bits (276), Expect = 1e-23
Identities = 105/488 (21%), Positives = 245/488 (50%), Gaps = 48/488 (9%)
Query: 649 TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
T+ +LK K + ++ + +E EK + + + KEL+R +E + + +++
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQL--NVKELKRKLERAKLLLPQQQLQAEADH- 269
Query: 709 LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEK-SFRE 764
L E +S++ + ++++E+N + ++ +EK +E +E +KI+++ EK +E
Sbjct: 270 --LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 765 EKIKDLKEE---RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
EKI++ +E+ +E + +K+ + E+ + +E E+ EK+EK I+E +EK
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE-EMMWEKEEK-IRELEEK 385
Query: 822 PEKRSQIKEKDIEKMER-KTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEK 880
++ +I+E++ ++ E K E+EK+ + E K + + + E +KI+E++K EK
Sbjct: 386 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 881 CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
H++ EK RE+ R+ +E +E + E +E + +K K +
Sbjct: 446 IHEQ----------------EKIREEEKRQEQEEMWRQEEKIREQEE--IWRQKEKMHEQ 487
Query: 941 SEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSL 1000
+ K E+ +++++ D++EK R++E + I+E+++ + Q EK
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI-----REQEEKIREQ 542
Query: 1001 KEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPAS 1060
+E +++ K + +EK ++ + + R +E+ + +++ K++ + +K + +
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE-------KIREQKEKIREQEE--- 592
Query: 1061 KDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI 1120
K +EK +++MQ E+M ++ EQ K +++ K + +E + L+
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 1121 KDKEKTKH 1128
++++ +H
Sbjct: 653 QEEKMQEH 660
Score = 105 bits (263), Expect = 4e-22
Identities = 97/435 (22%), Positives = 212/435 (48%), Gaps = 27/435 (6%)
Query: 603 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 654 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 713 MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 772
E E+K + ++ + +K K + + E E+ +KI++ EK +EKI++ +E
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRL--EEMMWEKEEKIRELEEKMHEQEKIREQEE 397
Query: 773 ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
+R E I + + M EE I E+E I +QEK + +EK ++ +I+
Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
E++ + + + + +E+KI+ + + + K + E +KI+++++ EK H + EK +
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE-QEKIRKQEEKVWRQEEKMHDQEEKIR 512
Query: 890 NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
K EK RE+ ++ + +EK ++ + + +E+ + E++ K + + + E+
Sbjct: 513 EQEE-KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Query: 949 GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 1008
+++++ ++KEK R++E + I+E+++ + Q EK +EK ++
Sbjct: 572 KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM-----QEQEEKMWEQEEKMCEQE 626
Query: 1009 LKTPDGKEKDKKDKD 1023
K + +EK ++ ++
Sbjct: 627 EKMQEQEEKMRRQEE 641
Score = 91.3 bits (225), Expect = 9e-18
Identities = 76/360 (21%), Positives = 183/360 (50%), Gaps = 24/360 (6%)
Query: 641 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 700
K ++E K ++ + ++ EK + ++E+ EKE+ K + + + E R + +
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 701 FKSDETEDLFLNMEHESLTLEKKSKL--EKNIKDDKSTKEKHVS---KERNFKEERDKIK 755
K ++ +L M + E++ K E+ I++ + +E+ +E +E+ +KI+
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 756 KESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
++ +K +R EEKI + ++ RE + E M EE I ++EI +K++ H
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKIR---EQEEIWRQKEKMH 485
Query: 815 IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKL 873
+E K E++ +E+ + E K E+E+K+ + E K + + + E +KI+E++++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTDDR-----EKSREKMDRKHDKEKP--EKERHLAESK 926
EK ++ EK + +++ +++ EK RE+ ++ ++E+ E+E + E +
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE-Q 604
Query: 927 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
E+ + E++ K + E ++ K +E++ ++ ++E+ ++ + + + +E + +
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 79.7 bits (195), Expect = 3e-14
Identities = 112/534 (20%), Positives = 232/534 (43%), Gaps = 90/534 (16%)
Query: 649 TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
T +K +L+ + K++EGE +D L S +F E E + T+
Sbjct: 136 TCQKTELQMALYYSQHAVKQLEGE-----ARDLISRLHDSWKFAGEL--EQALSAVATQK 188
Query: 709 LFLNMEHESLTLEKKS---KLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
+ E LT E+ + +L +N D+ KEK+ + + ESEKS +
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ------LVESEKSEIQL 242
Query: 766 KIKDLKEEREN----IPTDK-DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE 820
+K+LK + E +P + +E LG S L +E ++ + +E K
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM 302
Query: 821 -KPEKRSQIKEKDIEKMERKTFEKEKKIKH-EHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
+ E++ Q E+ I++ E K E+E+KI+ E K + + + E +K++ ++++
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362
Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
EK + E + EK RE ++ H++EK + E +EK E+K ++
Sbjct: 363 EKMRRLEEMM--------WEKEEKIRELEEKMHEQEK------IREQEEKRQEEEKIREQ 408
Query: 939 DNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 998
+ + +++ + +EK RE ++K + ++K+ QEEK HE+
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR-------QEEKI----------HEQ-- 449
Query: 999 SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSP 1058
EK ++++ +E + ++KI + + E + K K
Sbjct: 450 -----------------EKIREEEKRQEQEEMWRQEEKI------REQEEIWRQKEKMHE 486
Query: 1059 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK-----EKIKQKEKERLRNR 1113
K + +EK ++ M E+ +++ E + W ++ K EKI+++E E++R +
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEK---IREQEEKMWRQEEKIREQEEKIREQE-EKIREQ 542
Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSV 1167
E+ + +EK + + +E R + ++ + K ++ K+ + + + +
Sbjct: 543 E--EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Score = 78.6 bits (192), Expect = 6e-14
Identities = 78/392 (19%), Positives = 192/392 (48%), Gaps = 36/392 (9%)
Query: 601 KHKEKSKHQKDFHLEFGEK---SNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 657
+ +EK Q++ E+ EK KI++++ K ++E K ++ ++
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----------KIREQEEKMRRQEEMMW 345
Query: 658 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHES 717
++ EK + ++E+ EKE+ K + + + E RE +E + ++ + + E
Sbjct: 346 EKEEKMRRQEEMMWEKEE-KMRRLEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQEEE 403
Query: 718 LTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777
E++ + E+ K + +EK +E +E+ K+ ++ EK +EKI++ ++ +E
Sbjct: 404 KIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 462
Query: 778 PTDKDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEK---PEKRSQIKE 830
+ E + +H EK E + +QE+ + + +EK E++ +E
Sbjct: 463 EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522
Query: 831 KDIEKMERKTFEKEKKIKHEHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
+ I + E K E+E+KI+ + + +++ + + E +K++E++K+ EK ++ EK +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM-RRQEEKIREQEEKIR 581
Query: 890 NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
+ +EK RE+ ++ +EK ++ + + +E+ + E++ K + E + ++
Sbjct: 582 --------EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 949 GKNKEKDRELDKKE-KSRDKESINITNSKHIQ 979
K + ++ ++ ++E + R +E + +H++
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 62.4 bits (150), Expect = 4e-09
Identities = 95/553 (17%), Positives = 223/553 (40%), Gaps = 107/553 (19%)
Query: 378 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 434
R+ + E+ KE + ++ + EK+ + K K+K R +L ++ + L
Sbjct: 211 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270
Query: 435 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 489
+ S S + + +++ Q ++E + E K + ++ + + K +E +E
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 490 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 549
+E+E K + + + EK R + + K++ L + K K
Sbjct: 331 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRLEEMMWEKEEK---- 378
Query: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
+ E + +QE + E ++ R + E++ + ++ + K + + +
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEK 437
Query: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
K + E KI++E+ K+ ++E ++ EK + ++EI
Sbjct: 438 KMWRQEEKIHEQEKIREEE------------KRQEQEE--------MWRQEEKIREQEEI 477
Query: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
+KEK ++ ++ + V W++ EK E+
Sbjct: 478 WRQKEKMHEQEKIRKQEEKV------WRQE---------------------EKMHDQEEK 510
Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
I++ +EK +E +E+ +KI+++ EK +E++ +EE+ +K E +
Sbjct: 511 IREQ---EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 790 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
+E I +QE+ I+E KEK I + E K +E+E+KI+
Sbjct: 568 -------------RQEEKIREQEEKIREQKEK-----------IREQEEKIWEQEEKIRE 603
Query: 850 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDR 909
+ + ++ +++K++ + C +E + + +++ +++ +E R
Sbjct: 604 QEEMMQE------------QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 651
Query: 910 KHDKEKPEKERHL 922
+ +++ E + HL
Sbjct: 652 QQEEKMQEHQEHL 664
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 109 bits (273), Expect = 2e-23
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 66/621 (10%)
Query: 455 QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEK 514
+++KE V+ E ++ +V ++ + + + +E +E+EG E T +E+
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 515 TREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM 574
KS ++ S + KSP+ E+ +P + + + SP E
Sbjct: 509 AASPEKEAKSPVKEEAKSP-----AEAKSPE-----KEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 575 SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFE 634
P+ + E++ E S + K K + + + EK+ + +K+E SP
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 635 NSDCTLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR 693
S + K E K+ +K K KE K K + EKE+ K+ + AK ++
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK-SPEKEEAKSPEKAKSPVKAEA--- 674
Query: 694 EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVS--KERNFKEER 751
KS E + E +S K + +K++ + EK S KE E+
Sbjct: 675 --------KSPEKAKSPVKAEAKS-----PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 752 DKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQ 811
K + E E+ +KEE ++ K E K +D++
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA-----------------KTLDVKSP 764
Query: 812 EKHI--KESKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKS-EKDKLDLSECVDKI 867
E KE P + K K K E K+ EK K +K + K+ EK+ E +
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Query: 868 KEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKE 927
KE++K ++ K+ E+ K A KT++++ S+++ K + KP+ E + E
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEK-APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 928 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 987
K K + + +E K KE +++ KE ++ KE +
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK------------ 931
Query: 988 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1047
+ + A+ ++P EK + P K +EK KK ++ + + + K DK S K
Sbjct: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL--SKEPSKP 989
Query: 1048 EADKPKPKSSPASKDTRPKEK 1068
+A+K + SS KD++P EK
Sbjct: 990 KAEKAEKSSSTDQKDSKPPEK 1010
Score = 101 bits (252), Expect = 7e-21
Identities = 147/633 (23%), Positives = 262/633 (41%), Gaps = 52/633 (8%)
Query: 348 LPSKTP-LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
LP P +PS + K ++ ++ + + ++ +EQ +E + E T K+ K
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481
Query: 407 YPKSFKSKKQKPSRVLYSSTESSD-EEALQNKKISTSCSVIPETSNSDMQTK----KEYV 461
K + +++ + T+S EEA +K + S + E + S + K +E
Sbjct: 482 EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS--PVKEEAKSPAEAKSPEKEEAK 539
Query: 462 VSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF 521
E K K K K + K+ + +++E K + + E+ +
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPAEA 598
Query: 522 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 581
+ K + KSP + E+ +P + + + SP + E + P+
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSP-----VKEEAKSPAEVKSPEKAKSP-TKEEAKSPEKA 652
Query: 582 RYDNTESEFLPES--SSVKS-CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDC 638
+ E PE S VK+ K EK+K + EK+ + +K+E SP S
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712
Query: 639 TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ-RSVEFDREFW 696
+ K ++ K+ K + K E+ K K+E + EK K+ + AK L +S E
Sbjct: 713 KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-EKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 697 KENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 756
+E +D+ + + E + +K+K +K+D EK + K KEE K
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAK--SPLKEDAKAPEKEIPK----KEEVKSPVK 825
Query: 757 ESEKSFREEKIKD--LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
E EK +E K+K+ K E E P +E ++S +KE K E+
Sbjct: 826 EEEKP-QEVKVKEPPKKAEEEKAPATPKTEEK-------KDSKKEEAPKKEAPKPKVEEK 877
Query: 815 IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY 874
+ + EKP K S+++ K E E +KK+ K K+++ E K KEK
Sbjct: 878 KEPAVEKP-KESKVEAKKEEA------EDKKKVPTPEKEAPAKVEVKEDA-KPKEK---- 925
Query: 875 SHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKK 934
TE KE + +K K + +E + EK D K +K K +E+ E+K K +
Sbjct: 926 ---TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL 982
Query: 935 NKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
+K+ + K+EK + ++ ++ + DK
Sbjct: 983 SKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 100 bits (249), Expect = 1e-20
Identities = 144/580 (24%), Positives = 250/580 (43%), Gaps = 60/580 (10%)
Query: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDED-HSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
+ ++++K ++ E GE+ A+ +E+ SP E + K+ K K + K
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 660 REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
EKE+ K E K K K AKE +S + KE E + + E
Sbjct: 533 PEKEEAKSPAE-VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK----SPEKAKSP 587
Query: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
++++K K + K + ++ E + +K+E+ KS E K E+ PT
Sbjct: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA-KSPAEVK----SPEKAKSPT 642
Query: 780 DKDSEFTSLGMSAI-EESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
++++ S EE+ + + E + +S K E +S K K K E
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA 702
Query: 839 KTFEKEKK-IKHEHKS-EKDKLDLSE---CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 893
K+ EK K +K E KS EK K + E +K K K + EK K EK+K T
Sbjct: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-KSPEKAK-TLD 760
Query: 894 IK----KTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
+K KT +E++R D+ +K K P KE + K K + K++ ++ E K E+
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL-KEDAKAPEKEIPKKEE 819
Query: 949 GKN----KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT 1004
K+ +EK +E+ KE + E + +E+K S + K + KP ++EK
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKK 878
Query: 1005 KDEPLKTPDGKEKDKKDKDIDRYKERDKHKD-----KIQINSLLKLKSEADKPKPKSSPA 1059
+ K + K + KK++ D+ K K+ +++ ++ K K+E K +P + A
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 1060 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1119
+ ++P EK+ + T E+ KK +EK K E K
Sbjct: 939 KEPSKPAEKKEAAPEKKDTKEEKA------------KKPEEKPK------------TEAK 974
Query: 1120 IKDKEKT-KHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1158
K+ +KT P++ K ++ +S S++ D+ EK +D
Sbjct: 975 AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 92.0 bits (227), Expect = 5e-18
Identities = 103/480 (21%), Positives = 206/480 (42%), Gaps = 16/480 (3%)
Query: 702 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 761
KS+E + E E++ +E++++ E + ++ + +E+ +KE KEE ++E+E
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 762 FREEKIKDLKE----ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
E K +E E+E K+ + + E+ E + + + +E
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 818 SKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKSEKDKLDLSECVDKIKEKDKLYSH 876
+K PE +S KE+ E K+ EK K K E KS + + +KE+ K
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK---S 614
Query: 877 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKN 935
E E++K+ A +K + + ++ + +K K PEKE + K K ++ +
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 936 KQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
K + ++ + K+ EK + K+E KS +K + E+ KS + + K
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 995 EKPLSLKEKTKD-EPLKTPD-GKEKDKKDKDIDRYKERDKHK--DKIQINSLLKLKSEAD 1050
+ +KE+ K E K+P+ K D K + + + DK + +K E
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
P+ SP +D + EK + + +++ + +++++++ KK +E+ +
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 1111 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1170
++ + + KE K E K + + K S+V +A +E + K V + K
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV-EAKKEEAEDKKKVPTPEKEAPAK 913
Score = 72.8 bits (177), Expect = 3e-12
Identities = 95/404 (23%), Positives = 163/404 (40%), Gaps = 28/404 (6%)
Query: 810 KQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
K E+ IK EK EK + I E+ E+ E T E+EK+ K E E++ + E
Sbjct: 439 KSEEKIKVV-EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 867 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
+E + KE + A K+ KS EK + K E E+ + +K
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 927 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
E+ + K + E + K+ EK + K+E E+ + +K +E+ S
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 987 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1046
+ E+ S E E K+P +E +K KE K +K + +K
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK----SPVK 671
Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKE 1106
+EA P+ SP + + EK S E+ S E + +K K +K++
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS-PEKAKSPVKEEA 730
Query: 1107 KERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEV-TDAYTKEKQPKDAVSNRSQ 1165
K + ++ ++ + K EK K +P ++K ++ KS E T A + + P D +++
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAK-SPEKAKTLDV---KSPEAKTPAKEEARSPADKFPEKAK 786
Query: 1166 SVDTKNVMTLGKSSF------------VSDNSLNRSPRSENEKP 1197
S + V + K+ + +SP E EKP
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Score = 71.2 bits (173), Expect = 1e-11
Identities = 101/464 (21%), Positives = 182/464 (39%), Gaps = 52/464 (11%)
Query: 764 EEKIKDL-KEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 822
EEKIK + K E+E + ++ +E T + EE +EK KE + K
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE---------------EEKEAKEEEGKE 485
Query: 823 EKRSQIKEKDIEKMERKT------FEKEKKIKHEHKSEKDKLDLSECVDK--------IK 868
E+ + +E + + E K+ EK+ K K E ++ +K +K
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 869 EKDKLYSHHTEKCHK-------EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
+K S E+ E E++K+ A + K+ ++ KS K + K E E+
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-KSPEKAKSPAKEEAKSPAEAKSPEKA 604
Query: 922 LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQE 980
+ KE+ + K E + K+ EK + K+E KS +K E
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Query: 981 EKKSSIVDGNKAQHEKPLSLKEKTKD-EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQI 1039
+ KS + K+ + +K + K E K+P +E +K KE K +K +
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK- 723
Query: 1040 NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK 1099
+K EA P+ SP ++ + EK + L +K E + K+
Sbjct: 724 ---SPVKEEAKTPEKAKSPVKEEAKSPEK------AKSPEKAKTLDVKSPEAKTPAKEEA 774
Query: 1100 EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
K E+ ++ E+K +K K+ ++K E K EV +E++P++
Sbjct: 775 RSPADKFPEKAKSPVKEEVKSPEKAKSP-LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833
Query: 1160 -VSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSR 1202
V + + + K+ D+ +P+ E KP + +
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Score = 66.6 bits (161), Expect = 2e-10
Identities = 97/471 (20%), Positives = 170/471 (36%), Gaps = 40/471 (8%)
Query: 887 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 946
K K+ IK + EK E + + E+ + + E +EK E++ K+ + E ++
Sbjct: 437 KVKSEEKIKVVEKSEK--ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 947 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK--AQHEKPLSLKEKT 1004
E G+ + K ++ + + E KS + K A+ + P K
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 1005 KDEPLKTPDGKEKDKKD-KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDT 1063
K+E P+ K +K++ K K +K K + + K +EA P+ SP ++
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA--KSPAEAKSPEKAKSPVKEEA 612
Query: 1064 R-PKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRN----RNCLEL 1118
+ P E + + ++ E K + K EK K EKE ++ ++ ++
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672
Query: 1119 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1178
+ K EK K +P +++ K ++KS +A + EK K V ++S + KS
Sbjct: 673 EAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEK------AKS 724
Query: 1179 SFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESS 1238
+ +S ++ S A + D TP +
Sbjct: 725 PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP--------------A 770
Query: 1239 ESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLII 1298
+ + F AKSP E PE+ K P E+VK +
Sbjct: 771 KEEARSPADKFPEKAKSPVKEE------VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Query: 1299 SEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPE 1349
E EV+ P E +EE P +P PK E
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Score = 64.3 bits (155), Expect = 1e-09
Identities = 77/376 (20%), Positives = 153/376 (40%), Gaps = 28/376 (7%)
Query: 822 PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKC 881
P + IK K E+KIK KSEK+ + + E ++ + TE+
Sbjct: 430 PSVSTHIKVK-----------SEEKIKVVEKSEKETVIVEEQTEE--------TQVTEEV 470
Query: 882 HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNS 941
+E EK K+ + E+ + + K P +E E + K ++++ K +
Sbjct: 471 TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530
Query: 942 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
+ + E+ K+ + + +K + +E+ + +K ++E+ S A+ + P K
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS-----PAEVKSPEKAK 585
Query: 1002 EKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK 1061
K+E K+P + +K K + + + + K + K +E P+ SP +
Sbjct: 586 SPAKEE-AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 1062 DTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK 1121
+ + EK + S E+ S E + +K K +K + K + ++ ++ + K
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS-PEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 1122 DKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFV 1181
EK K +P + + K ++KS +A T EK K V ++S + K+ V
Sbjct: 704 SPEKAK-SPVKEEAKSPEKAKSPVKEEAKTPEK-AKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 1182 SDNSLNRSPRSENEKP 1197
+ E P
Sbjct: 762 KSPEAKTPAKEEARSP 777
Score = 42.0 bits (97), Expect = 0.006
Identities = 86/457 (18%), Positives = 167/457 (36%), Gaps = 53/457 (11%)
Query: 29 KSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSEN 88
K+K + +K+P +S V +E K + +K SP++ E + + P
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP-EKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 89 WGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDN 148
E+ S + +E + PEK K+ +A K ++ ++ A+
Sbjct: 662 SPEKAKSPVK--AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719
Query: 149 SPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLG 208
+P TP + K+P + + K E+ +T
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT--------------------- 758
Query: 209 ANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD---TPLHDSASSGHRD 265
++VK TP E K A + V + + +PL + A + ++
Sbjct: 759 --LDVKSPEAKTPAKEEAR---SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
Query: 266 IVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPS 325
I K +P K E+P +V E + + + P + E DS++ ++
Sbjct: 814 IPK--KEEVKSPV---KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 326 SVDENIDSETE------KDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRH 379
+ ++ + E K+S + K+ K +P+ E K + E+ K +
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-KPKEKTE 927
Query: 380 ILRKE----QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQ 435
+ +KE + KE AEK A ++K + K ++KP + D++ L
Sbjct: 928 VAKKEPDDAKAKEPSKPAEKKEA-APEKKDTKEEKAKKPEEKPKT---EAKAKEDDKTLS 983
Query: 436 NKKISTSCSVIPETSNSDMQTKKEYVVSGEHK-QKGK 471
+ ++S++D + K + E K KGK
Sbjct: 984 KEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 38.5 bits (88), Expect = 0.069
Identities = 36/168 (21%), Positives = 66/168 (39%), Gaps = 27/168 (16%)
Query: 23 EKPYGRKSKD--KIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDS 80
EKP K K+ K A K P +++ K+ K++ + K++ P P E+++ +
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP---KPKVEEKKEPAVEK 884
Query: 81 DPGHTSENWGERLISSYRTYS-EKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMAL 139
E E + + EKE P K + K++A K+ T V
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV---------------- 928
Query: 140 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGET 187
A+ D+ PS+ ++ P +++K K E+ +T
Sbjct: 929 -----AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 104 bits (259), Expect = 1e-21
Identities = 205/919 (22%), Positives = 352/919 (38%), Gaps = 166/919 (18%)
Query: 383 KEQRKENEPEAEKTHLFAKQEKA-FYPKSFK-SKKQKPSRVLYSSTESSDEEALQNKKIS 440
KE+ E+ + EK+ + E PKS + S P + + T+ + L NK +
Sbjct: 249 KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQ 308
Query: 441 TSCSVIPETSNSDMQTKKEYVVSGEHKQ--KGKVKRKLKNQNKNKENQELKQEKEGKENT 498
S S + K + GE K+ K K ++K + K+++ Q++K EK+ KE
Sbjct: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK- 367
Query: 499 RITNLTVNTGLDCSEKTREEGNFRKSFSPKDD---------------TSLHLFHISTGKS 543
+ +L + + + ++ EG ++ FS D + L F T +
Sbjct: 368 EVESLKLPSEKNSNKAKTVEGT-KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
Query: 544 PKHSCGLSEKQSTP-----LKQEHTKTCLSPGSSEMSL--------QPDLVR--YDNTES 588
S + E + T KQ TKT S S + +P L Y +++
Sbjct: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486
Query: 589 EFLPESSSVKSCKHKEKSKHQKDFHLE-FGEKSNAKIK-----------------DEDHS 630
E E K KE+ ++ + E EK K + +E +
Sbjct: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
Query: 631 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 690
+ E +K++ KE K L+K K+R+K+ E +K++ +DS + L+ S
Sbjct: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
Query: 691 FDREFWKENFFKSDETEDLFLNME--------HESLTL----EKKSKLEKNIKDDKST-- 736
+ KE S E + + E ESL + + +SKLE+ K ST
Sbjct: 607 CE----KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
Query: 737 ------------------------KEKHVSKERNFKEERDKIKKESE----KSFREEKIK 768
E+ ++ K E+ K +SE KS ++++K
Sbjct: 663 IMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVK 722
Query: 769 DLKE--ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 826
KE ERE P++ L + + +H E ++ EK +K + ++
Sbjct: 723 SSKEKPEREKTPSE-----DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQ 777
Query: 827 QIKEKDIEKMERKTFEKEKKIKHEHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
Q K +K ERK+ K ++E K KD +SE + K E K
Sbjct: 778 QTKLSSDDKTERKS-----KHRNERKLSVLGKDGKPVSEYIIKT----------DENVRK 822
Query: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH---LAESKEKHLMEKKNKQSDN 940
E K + + +KT KSR D K K+ ++H L E + +K + S N
Sbjct: 823 ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882
Query: 941 SEYS-KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 999
+ + K E+ +KEK R E+ +S + T K + + ++ + +G Q P
Sbjct: 883 MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQV-KVVETELQEGATKQATTPKP 941
Query: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK-LKSEADKPKPKSSP 1058
KEK +E + EK +K K DK ++ + +L+ S A + SS
Sbjct: 942 DKEKNTEE-----NDSEKQRKS------KVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990
Query: 1059 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLEL 1118
+K KEK + D T ER LS HK K K+
Sbjct: 991 RAKLPLAKEKYKSDKDSTSTRLERKLS-------DGHKSRSLKHSSKD------------ 1031
Query: 1119 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1178
IK K++ K + K + + K + + ++K + NR S+ + M G+
Sbjct: 1032 -IKKKDENKSDDKDGKEVDSSHEK-ARGNSSLMEKKLSRRLCENRRGSLSQE--MAKGEE 1087
Query: 1179 SFVSDNSLNRSPRSENEKP 1197
+ N+L+ S ++P
Sbjct: 1088 KLAA-NTLSTPSGSSLQRP 1105
Score = 74.7 bits (182), Expect = 9e-13
Identities = 111/522 (21%), Positives = 207/522 (39%), Gaps = 62/522 (11%)
Query: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKK--------IKHEHKSEKDKLDLSECVDKI 867
+ SK+ P + + D E+ +KEK ++ KSE+ DL V++I
Sbjct: 232 RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEI 290
Query: 868 KEKDKLY--------------SHHTEKCHKEGEKS--KNTAAIKKTDDREKSREKMDRKH 911
K K + S K +GEK N +K + +EK+ +K D
Sbjct: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK 350
Query: 912 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE---KDRELDKKEKSRDKE 968
E +K + ++KEK + K NS +K+ +G ++ D ++D
Sbjct: 351 KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVS 409
Query: 969 SINITNSKHIQEEKKSSIV------DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK 1022
S++ ++ +E+ + +V +G ++ + + KTK + + +GK K +
Sbjct: 410 SVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHA 469
Query: 1023 DIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK--EKRLVNDDLMQTS 1079
+ + Y + D ++ + + K K + + R K EKR + ++S
Sbjct: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS 529
Query: 1080 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI----KDKEKTKHTPTESKN 1135
+ +++E+ K E + KE L+ R LE K+ K K+ +++ SK
Sbjct: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589
Query: 1136 KELTRSKSSEVTDAYTKEKQPKDAVSN-------RSQSVDTKNVMTLGKSSFVSDNSLNR 1188
K+ S E T E K+ +S+ ++S +K L +S V D + N
Sbjct: 590 KQQYEEDSKETLK--TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647
Query: 1189 SPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPV-----EYDSDFMLESSESQMS 1243
S + E E +S V M V D+ R + + + +
Sbjct: 648 S-KLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
Query: 1244 FSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSH 1285
S++P L +L ++E+ S + PER K P ++LS H
Sbjct: 707 DSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
Score = 70.5 bits (171), Expect = 2e-11
Identities = 148/777 (19%), Positives = 299/777 (38%), Gaps = 134/777 (17%)
Query: 331 IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE-- 388
+D + L E K+ +T P ++ + ++ D ++ + ++ I +E +K+
Sbjct: 641 VDENKNESKLEREHKR----RTSTPVIMEGVQ-EETDTRDVKRQVERSEICTEEPQKQKS 695
Query: 389 ---NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
NE +K K+ K KS K+KP R T S D+ ++++K C +
Sbjct: 696 TLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPER---EKTPSEDKLSVKHK-YKGDC-M 750
Query: 446 IPETSNSDMQTKKEYVVSGEHKQKGKVKRKL----KNQNKNKENQELKQEKEGKENTRIT 501
+++ + ++ + E+ QK + KL K + K+K E K GK+ ++
Sbjct: 751 HKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVS 810
Query: 502 NLTVNTGLDCSEKTREEGNF--RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLK 559
+ T E R+E N R+ + K S K K S G + T +
Sbjct: 811 EYIIKT----DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQR 866
Query: 560 QEHT----KTCLSPGSSEMSLQPD-LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL 614
+ + K + + + +L+P+ +V + ++ L E V K K + K K
Sbjct: 867 RSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVET 926
Query: 615 EFGE---KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLK----------HKERE 661
E E K K + T EN +K E K ++ ++ H ++
Sbjct: 927 ELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQK 986
Query: 662 KEKHKKEIEGEKEKYKT-KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
H+ ++ KEKYK+ KDS S +R+ + +S ++H S +
Sbjct: 987 DSSHRAKLPLAKEKYKSDKDST-----STRLERKLSDGHKSRS---------LKHSSKDI 1032
Query: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
+KK + + + KD K H N K+ + ++ R +++ + E + +
Sbjct: 1033 KKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAAN 1092
Query: 781 KDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEKPEKRSQIKEKDI--E 834
S + + ++S + L+ + EID E +++ E + + R+ ++DI E
Sbjct: 1093 TLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSE 1152
Query: 835 KMERK---TFEKEK--------------------------KIKH-EHKSE-KDKLDLSEC 863
M++K T +K++ KH +H+S K+ +
Sbjct: 1153 NMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSA 1212
Query: 864 VDKIKEKDKLYSHH--------TEKCHK-------EGEKS----KNTAAIKKTDDREKSR 904
V K+ +K H +E H+ E ++ KNTAA + + +
Sbjct: 1213 VSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATL 1272
Query: 905 EKMDRKHDKEK-------PEKERH----LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE 953
E P +E + + ++ ++E + +++S
Sbjct: 1273 EHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTV 1332
Query: 954 KDRELDKKEKSRD---------KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
++ E+ K S++ +IT+ +HI E +++++DG + + PL K
Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSK 1389
Score = 52.0 bits (123), Expect = 6e-06
Identities = 61/318 (19%), Positives = 138/318 (43%), Gaps = 29/318 (9%)
Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK-HLMEKKNKQ 937
E+ H E ++ +K D+ E KE E+ERH+ + K K H + +++
Sbjct: 2726 EEIHSESYNKGEISSGRK-DNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784
Query: 938 SDNSEY--SKSEKGKNK--EKDRELDKKEKSRDKESINITNSK------HIQEEK---KS 984
DN + S+ E + + E + K+E SRD E + T+S+ + EEK S
Sbjct: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844
Query: 985 SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK 1044
S G K + ++K + +D+P+ + + +K K +D K I ++ +
Sbjct: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904
Query: 1045 LKSEADKPKPKSSPASKDTRPKEKRLVNDD----LMQTSFER--------MLSLKDLEIE 1092
S + ++ ++K+T ++R +++D + TS R + D E
Sbjct: 2905 SPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964
Query: 1093 QWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTK 1152
+ +K ++ + +++ + E + +++++ T S + + ++++ + +
Sbjct: 2965 EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024
Query: 1153 EKQ--PKDAVSNRSQSVD 1168
+++ P A + Q V+
Sbjct: 3025 KREVSPPGARTRGQQRVE 3042
Score = 50.4 bits (119), Expect = 2e-05
Identities = 93/503 (18%), Positives = 180/503 (35%), Gaps = 91/503 (18%)
Query: 512 SEKTREEGNFRKSFSPKDDTSL------HLFHISTGKSPKHSCG-------LSEKQSTPL 558
+EKT ++ + RKSF + D + ++ I +SP + G L + P
Sbjct: 2619 AEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
Query: 559 KQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGE 618
++E L+P S +P + E + ES +V E
Sbjct: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNV--------------------E 2718
Query: 619 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 678
S + +E HS ++ + + + D + + H ++ +E E+ ++ + K K
Sbjct: 2719 NSGFRTNEEIHSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHY 2777
Query: 679 KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKE 738
S E D+ D+ S++E + T E
Sbjct: 2778 LSSEDE------------------PDDNPDVL------------DSRIETAQRQCPET-E 2806
Query: 739 KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG 798
H +KE N ++ + K SE + ++ + K+E + T + E++
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKP---------EQNDD 2857
Query: 799 LHLVEKEIDIEKQEKHIKESKEKPEK---RSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
+ +E E Q IK + +P K + +K KD K + + E
Sbjct: 2858 DTIKSQE---EDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI------VTVEQSPSS 2908
Query: 856 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK 915
KL + + + KE L + +GE+ T+ ++ K + + D E
Sbjct: 2909 SKLKVMQTDESNKETANLQERSIS--NDDGEEKIVTSVRRRG---RKPKRSLTVSDDAES 2963
Query: 916 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 975
E ER +S + +KK ++SD E + E + R + E R K ++ +
Sbjct: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIK 3023
Query: 976 KHIQEEKKSSIVDGNKAQHEKPL 998
+ + + G + E P+
Sbjct: 3024 RKREVSPPGARTRGQQRVEEAPV 3046
Score = 40.4 bits (93), Expect = 0.018
Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 58/338 (17%)
Query: 236 ILIAAGADVNTQGLDDDTPLHDSA------SSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
+L+ +V G + +H + SSG +D + + H D
Sbjct: 2709 LLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVE-----------AD 2757
Query: 290 VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS------ETEK------ 337
E EE E R +P + Y SE+ NP +D I++ ETE
Sbjct: 2758 PKEVEEEE----RHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813
Query: 338 -----DSLICESKQILPSKTPLPSALDEYEFKD--------DDDEEINKMIDDRHILRKE 384
+ L S + + + + DEY + +DD+ I +D+ I+ K
Sbjct: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
Query: 385 QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS----RVLYSSTESSDEEALQNKKIS 440
+R +T L K + + +Q PS +V+ + + + LQ + IS
Sbjct: 2874 KRGRPRKYPVETTLKMKDDSK-TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSIS 2932
Query: 441 TSC---SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN---KNKENQELKQEKEG 494
++ + K+ VS + + +++ K+ + ++K+ QE +E+E
Sbjct: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
Query: 495 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTS 532
+E + T + SE R + S K + S
Sbjct: 2993 EEEDEPSGATTRS-TTRSEAQRSKTQLSPSIKRKREVS 3029
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 103 bits (257), Expect = 2e-21
Identities = 121/568 (21%), Positives = 261/568 (45%), Gaps = 79/568 (13%)
Query: 603 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 654 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 713 MEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFK---------EERDKIKKESEK 760
E E+K + ++ + K++K +++ + E+ K E+ +KI++ EK
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 399
Query: 761 SFREEKIKDLKEER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
+EKI++ +E+R E I + + M EE I E+E I +QEK +
Sbjct: 400 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWR 455
Query: 818 SKEKPEKRSQIKEKDIEKMERKTFEKEKKI--------------KHEHKSEKDKLDLSEC 863
+EK ++ +I+E++ + + + + +E+KI + E K K + +
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 864 VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA 923
+KI+E+++ EK ++ EK I++ ++ + EKM H++EK +E
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEK------IREQEEMWREEEKM---HEQEKIWEEEKRQ 566
Query: 924 ESKEK-HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK 982
E ++K E+K ++ + + + EK + +E+ R+ +++ + +E I K ++E+
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 983 KSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK--DKKDKDIDRYKERDKHKDKIQIN 1040
K + Q EK +E T+++ K + +EK ++++K ++ + + ++KI+
Sbjct: 627 KI------REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR-- 678
Query: 1041 SLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE 1100
E +K K +EK +++MQ E+M ++ EQ K ++
Sbjct: 679 -------EQEK---------KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722
Query: 1101 KIKQKEKERLRNRNCLELKIKDKEKTKH 1128
+ K + +E + L+ ++++ +H
Sbjct: 723 EEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 80.5 bits (197), Expect = 2e-14
Identities = 113/575 (19%), Positives = 256/575 (44%), Gaps = 88/575 (15%)
Query: 369 EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 428
+E+ + ++ +L +Q+ + AE HL K S K + Q L++
Sbjct: 245 KELKRKLERAKLLLPQQQLQ----AEADHL----GKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 429 SDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQ 486
EE + Q +KI I E ++ ++E + E K + + + + + K + +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEK-IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 355
Query: 487 ELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKH 546
E+ EKE EK R + + K++ + K K
Sbjct: 356 EMMWEKE-------------------EKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK- 392
Query: 547 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 606
+ E + +QE + E ++ R + E++ + ++ + K +
Sbjct: 393 ---IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIRE 448
Query: 607 KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK-EKH 665
+ +K + E KI++E+ E +K+ ++ + ++ + H++ EK K
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ 508
Query: 666 KKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSK 725
++++ ++EK + ++ ++ E + + W++ K E E+++ E+K
Sbjct: 509 EEKVWRQEEKIREQE-----EKIREQEEKMWRQE-EKIREQEEMWRE--------EEKMH 554
Query: 726 LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEKIKDLKEERENIPTDKDSE 784
++ I ++ EK +E + +KI+++ EK +R EEKI++ +E+R+ +++ +
Sbjct: 555 EQEKIWEE----EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ----EQEEK 606
Query: 785 FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTF 841
M EE I E+E I++QE+ I+E +EK ++ ++ ++ EKM E K
Sbjct: 607 -----MWKQEEKIR----EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 657
Query: 842 EKEKKI--------KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 893
E+E+K+ + E K + + + E +KI+E++++ EK ++ EK
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK------ 711
Query: 894 IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
+ + +++ + +E+ R+ +++ E+E L + +EK
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 46.2 bits (108), Expect = 3e-04
Identities = 66/325 (20%), Positives = 144/325 (44%), Gaps = 41/325 (12%)
Query: 829 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKS 888
K+K +E T E++ +++ +L E K++EK +L E EKS
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV---------ESEKS 238
Query: 889 K---NTAAIKKTDDREK---SREKMDRKHD---KEKPEKERHL-AESKEKHLMEKKNKQS 938
+ N +K+ +R K ++++ + D KE L A+ +E L + N+Q
Sbjct: 239 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ 298
Query: 939 DNSEYSKSEKGKN-KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKP 997
+ + + EK + +EK +E ++K + ++++ QEE + + Q E
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 998 LSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1057
+EK + + + +EK ++ +++ KE + + +++ K++ + +K + +
Sbjct: 359 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418
Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
R +EKR + M E++ ++ +EKI+++EK+ R E
Sbjct: 419 -----IREQEKRQEQEAKMWRQEEKI------------REQEEKIREQEKKMWRQ----E 457
Query: 1118 LKIKDKEKTKHTPTESKNKELTRSK 1142
KI ++EK + + +E+ R +
Sbjct: 458 EKIHEQEKIREEEKRQEQEEMWRQE 482
Score = 39.3 bits (90), Expect = 0.040
Identities = 56/320 (17%), Positives = 130/320 (40%), Gaps = 12/320 (3%)
Query: 842 EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 896
E I H S K +L + + + + K + E+ KE E +NT ++
Sbjct: 159 EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218
Query: 897 TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDR 956
++ ++ + + EK E + ++ E K K K + GK +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-- 276
Query: 957 ELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKE 1016
+ K +++ +E+ QEEK + + EK +EK +++ K + +E
Sbjct: 277 -VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 335
Query: 1017 KDKKDKDIDRYKERD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDL 1075
K ++ +++ KE + ++++ K++ + + K K R +E ++
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEK 392
Query: 1076 MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1135
++ E+M + + ++ ++ +EKI+++EK + + + K +E+ + + K
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452
Query: 1136 KELTRSKSSEVTDAYTKEKQ 1155
K E +EK+
Sbjct: 453 MWRQEEKIHEQEKIREEEKR 472
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 103 bits (257), Expect = 2e-21
Identities = 101/461 (21%), Positives = 226/461 (49%), Gaps = 37/461 (8%)
Query: 665 HKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEHE 716
HKK +E K +D+ EL R+ + E K+N E ++ LN++
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 717 SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEEREN 776
LE+ L ++ + + +E+ +E +E+ KI+K+ EK +R+E+ L+E+
Sbjct: 214 KRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--RLREQEGK 270
Query: 777 IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM 836
+ ++ M E+ L E+E ++ +QEK ++E K+ E+ Q++E++ EKM
Sbjct: 271 MREQEEK------MRRQEK----RLREQEKELREQEKELREQKKLREQEEQMQEQE-EKM 319
Query: 837 ---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
E K E+E+K+ + E + + + + E K++++++ E+ ++ E+ +
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379
Query: 893 AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNK-QSDNSEYSKSEKGKN 951
+ + +++ + E++ R+ +K+ E+E + E +EK +++N + + E+ + +
Sbjct: 380 KMWEQEEKMQEEERI-REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 952 KEKDRELDKKEKSRDK---ESINITNSKHI-QEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
KEK E +K ++ +K + I + + + +EKK + + Q ++ +EK +D+
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 1008 PLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKE 1067
K D +E+ + + R KE + K K++ E K+ K T +E
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE-----KKTQEQEKKTWDQE 553
Query: 1068 KRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
+++ ++ M+ ++M +++ EQ K +++ K +E+E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 100 bits (250), Expect = 1e-20
Identities = 116/578 (20%), Positives = 258/578 (44%), Gaps = 49/578 (8%)
Query: 603 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK 662
K+ ++ Q+ L EKS ++ ++ E + L ++ + TL++ + +E +
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV--QTNTLQEEMWRQEEELR 244
Query: 663 EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEK 722
E+ KK + E++ ++ ++ +E + + E + + E E E E L +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE---LRE 301
Query: 723 KSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD 782
+ KL + + + +EK +E +E+ +K+ ++ E+ + +EK E+E D++
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK---QMREQEQKMRDQE 358
Query: 783 SEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 842
E+ + EK + E++ + + +E+ EK+ + +E+ + + E K +
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER-EKKMREEEETMREQEEKMQK 417
Query: 843 KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI----KKTD 898
+E+ + + + E + L E +K+ E++K+ EK ++ EK ++ + KK
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 899 DREKSREKMD-------RKHDKEKP---------EKERHLAESKEKHLMEKKNKQSDNSE 942
+EK RE+ D + D+E+ E++ L E +E+ M ++ K E
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER--MREQKKMWQQEE 534
Query: 943 YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKE 1002
+ EK +++ + D++EK R++E + K +EE+ + Q EK +E
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM------REQEEKMQEQEE 588
Query: 1003 KTKDEPLKTPDGKEKDKKDKDIDRYKERDK-----HKDKIQINSLLKLKSEADKPKPKSS 1057
K +++ K + +EK ++++ +++ +K +DK+Q + + E +
Sbjct: 589 KMREQEEKMWEQEEK-MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE----EKMQE 643
Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
K +EK ++ M+ E+M ++ EQ K ++ K +E+E + R E
Sbjct: 644 QEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE-KMRGQEE 702
Query: 1118 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
+EK + +E R K + D K ++
Sbjct: 703 KMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 96.3 bits (238), Expect = 3e-19
Identities = 92/500 (18%), Positives = 249/500 (49%), Gaps = 54/500 (10%)
Query: 644 DKEGKTLKKH-KLKHKEREKEKHKKEI-EGEKEKYKTKDSAKELQRSVEFDREFWKENFF 701
++EGK ++ K++ +E+ + +KE+ E EKE + K ++ ++ E + + W++
Sbjct: 266 EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325
Query: 702 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 761
++ E ++ E E++ ++ + + + +E+ ++ +E+ ++++++ +
Sbjct: 326 MREQEEKMW---RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 762 FREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
+EEK+++ + RE ++ E T + E+E ++KQE+++ E +EK
Sbjct: 383 EQEEKMQEEERIREREKKMREEEET--------------MREQEEKMQKQEENMWEQEEK 428
Query: 822 -------PEKRSQIKEKD-IEKMERKTFEKEKKIKHEHK--SEKDKL----DLSECVDKI 867
PE++ ++ E++ +++ E K +E+E+KI+ + + ++ K+ + E D++
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 868 KEKDKLYSHHTEKCHKEGEKS-KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
E+++ +K + E+ + +++ ++R + ++KM ++ +K + EK+ E K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Query: 927 ----------EKHLMEKKNKQSDNSEYSKSEKGK---NKEKDRELDKKEKSRDKESINIT 973
E+ + E++ K + E + ++ K +EK RE ++K ++++
Sbjct: 549 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE 608
Query: 974 NSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKH 1033
QEEK + +K Q ++ + ++ +E ++ + K ++++K ++ ++ +
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQ---EEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 1034 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
++K+Q K++ + +K + + K +EK ++ M E+M ++ Q
Sbjct: 666 EEKMQ-GQEEKMREQEEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721
Query: 1094 WHKKHKEKIKQKEKERLRNR 1113
+ KE+ + +KE+++ R
Sbjct: 722 EEMREKEERIRDQKEKMQER 741
Score = 90.9 bits (224), Expect = 1e-17
Identities = 121/581 (20%), Positives = 260/581 (44%), Gaps = 71/581 (12%)
Query: 592 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
PE+++ + C E K H E + +I+ +DH T C KT
Sbjct: 58 PETTTSEGCHSPEDEKKASHQHQEALRR---EIEAQDH--TIRILTCQ--------KTEL 104
Query: 652 KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK-----ENFFKSDET 706
+ L + + K + GE +KD A L S F E + + K +
Sbjct: 105 ETALYYSQDAARKFEDGNLGE-----SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADR 159
Query: 707 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK-KESEKSFREE 765
L E ++L+LE L +N ++ K+K+ E ++K++ ESEKS +
Sbjct: 160 YIEELTKERDALSLE----LYRNTITNEELKKKNA-------ELQEKLRLAESEKSEIQL 208
Query: 766 KIKDLKEEREN----IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
+K+LK + E +P + + EE L E+E I KQE+ + +E+
Sbjct: 209 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE-----LREQEKKIRKQEEKMWRQEER 263
Query: 822 ---PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
E + + +E+ + + E++ E+EK+++ + K +++ L E ++++E+++
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
EK ++ EK + + ++R +EK R+ +++ ++E + E E+ +++ +
Sbjct: 324 EKMREQEEK------MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377
Query: 939 DNSEYSKSEKGKNKEKDRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
+ + EK + +E+ RE +KK E R++E +++ E+++ +
Sbjct: 378 QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437
Query: 994 HEKPLSLKEKTKDEPLKTPDGKEKDK-------KDKDIDRYKERDKHKDKI--QINSLLK 1044
++ L +EK +++ K + +EK + ++K + R ++ + +D++ Q +
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 1045 LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQ 1104
+ + + + + R KE+R+ M E+M K + EQ K ++ K
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ-EQEKKTWDQEEKM 556
Query: 1105 KEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
+E+ER+R R E K++++E+ E ++ + + E
Sbjct: 557 REEERMRER---EKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 71.2 bits (173), Expect = 1e-11
Identities = 110/580 (18%), Positives = 240/580 (41%), Gaps = 83/580 (14%)
Query: 358 LDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAE---KTHLFAKQEKAFYPKSFKSK 414
L E E K EE KM LR+++ K E E + + +QEK + + +
Sbjct: 243 LREQEKKIRKQEE--KMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
+QK R + +E+ + ++ + ++E + + KQ + ++
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEE--------KMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 475 KLKNQNKNK-ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSL 533
K+++Q + E E +EKE + + + E+ RE K +++T
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER---EKKMREEEETMR 409
Query: 534 HLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPE 593
K K + E++ +Q+ + +Q + E + +
Sbjct: 410 E----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Query: 594 SS---SVKSCKHKEKSKHQKDFHLEFGEKS-NAKIKDEDHSPTFENSDCTLKKMDKEGKT 649
K +EK + Q+D E EK + + K D D L+ +KE +
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERM 523
Query: 650 LKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL 709
++ K+ +E + + KK E EK+ + ++ +E +R E +++
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-------------- 569
Query: 710 FLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 769
E E + E++ K+++ + + +EK +E +E+ +K+ ++ EK + +E+
Sbjct: 570 ---REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626
Query: 770 LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
++E+ E + E+E +++QE+ + E +EK ++ +
Sbjct: 627 MQEQEEM------------------------MWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK-EKDKLYSHHTEKCHKEGEKS 888
+ EKM+ ++EK + E K + + + E +K++ +++K++ G++
Sbjct: 663 REQEEKMQG---QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMW----------GQEE 709
Query: 889 KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
K +K +E+ REK +R D+++ +ER L E +E+
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQER-LPEHEER 748
Score = 38.9 bits (89), Expect = 0.053
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 13/201 (6%)
Query: 297 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPL-- 354
E + ++E + + +E D E+ + E + EK+ + E K++ + +
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 355 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 414
E E K D EE KM ++ + +E++ E E + +QE+ + K +
Sbjct: 539 EKKTQEQEKKTWDQEE--KMREEERMREREKKMREEEE-----MMREQEEKMQEQEEKMR 591
Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
+Q+ ++ E E+ + K + + MQ ++E + E K + + ++
Sbjct: 592 EQEEK--MWEQEEKMQEQ--EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Query: 475 KLKNQNKNKENQELKQEKEGK 495
+ + K +E +E +E+E K
Sbjct: 648 MWEQEEKMREQEEKMREQEEK 668
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 103 bits (256), Expect = 2e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 168 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
Query: 228 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 287
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
Query: 288 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 339
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
Query: 340 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 382
L + +K L A + KD D +E ++D D ++
Sbjct: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
Query: 383 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
Query: 443 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 502
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
Query: 503 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 562
++KT+ S + + +S ++ +P S G + S K
Sbjct: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
Query: 563 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 621
T T +SP E + P R ++ + + + K +K EK
Sbjct: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
Query: 622 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 681
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
Query: 682 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 741
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
Query: 742 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 794
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
Query: 795 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
Query: 855 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 914
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
Query: 915 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 947
K+++ E + + S ++ S S
Sbjct: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
Query: 948 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
Query: 1008 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1063
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
Query: 1064 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
Query: 1118 LKIKDKEKTKHTPTESKNK 1136
++ +++ + +E + +
Sbjct: 982 MEKRERRALERRISEMEEE 1000
Score = 40.4 bits (93), Expect = 0.018
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 859 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
Query: 919 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
Query: 977 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
SS A +S + T P+K KE+++KD+
Sbjct: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
Query: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
+I KE K KD + A P+ SS +K+ K
Sbjct: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
Query: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
Query: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
Query: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
Query: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
R T + + E KQ + EE + +TS + + +S +
Sbjct: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
Query: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
+ +S +T+P+ + S+S Y S+ N
Sbjct: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
Score = 37.4 bits (85), Expect = 0.15
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
Query: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
E E T + T+ S+ + + + + + P S IK+
Sbjct: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
Query: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
Query: 891 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
Query: 942 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
S S +G K +++ S+ +T++ +
Sbjct: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
Query: 979 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
Q+ SS K + + + L D EK+K
Sbjct: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Query: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
Query: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
Query: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
Query: 1185 SLNRSPRSENEKPG 1198
+ +R ENE+ G
Sbjct: 809 AYSRGITKENEREG 822
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
isoform a [Homo sapiens]
Length = 1030
Score = 103 bits (256), Expect = 2e-21
Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)
Query: 168 PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
P RQK KV + + G L A GD +V +L+ GA++N + G T LH+AC
Sbjct: 26 PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82
Query: 228 VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 287
D+ K L+ GA++N + PLH +AS G+ DI + L+ G + N G+ P
Sbjct: 83 DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142
Query: 288 VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 339
+D+AE E +E LL+ EV D EE Q +N +++ +++ +
Sbjct: 143 LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202
Query: 340 L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 382
L + +K L A + KD D +E ++D D ++
Sbjct: 203 LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262
Query: 383 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
K + + E + ++ + K+ K S ++ S+ + ++ + K +
Sbjct: 263 KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322
Query: 443 CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 502
+ PE + S +++ ++ V E + K K ++ ++E++E E E +
Sbjct: 323 LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370
Query: 503 LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 562
++KT+ S + + +S ++ +P S G + S K
Sbjct: 371 ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416
Query: 563 TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 621
T T +SP E + P R ++ + + + K +K EK
Sbjct: 417 TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464
Query: 622 AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 681
A + SP +S K+ +K+ K + + + +IE EKE +DS
Sbjct: 465 AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519
Query: 682 AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 741
+ L+ S + R W+++ K+ + + H+S + ++ + +T V
Sbjct: 520 S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576
Query: 742 SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 794
+ ++ KI S + + + ++ +KDS T++ +
Sbjct: 577 TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636
Query: 795 ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854
+ + ++ + +RS + E+ E + + ++ + +S
Sbjct: 637 TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696
Query: 855 KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 914
+ + ++E +K +E E + K+ D+EK EK + + +E
Sbjct: 697 Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751
Query: 915 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 947
K+++ E + + S ++ S S
Sbjct: 752 DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811
Query: 948 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
+G KE +RE +K+E+ +KE + + K I+E ++ + E +++
Sbjct: 812 RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869
Query: 1008 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1063
T +G K + D I RY E + +SLL S ++ KP SS KD
Sbjct: 870 QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928
Query: 1064 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
K+L N+ L + + L DL+++ EK Q++ ER +R+ LE
Sbjct: 929 STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981
Query: 1118 LKIKDKEKTKHTPTESKNK 1136
++ +++ + +E + +
Sbjct: 982 MEKRERRALERRISEMEEE 1000
Score = 40.4 bits (93), Expect = 0.018
Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)
Query: 859 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
D+ ++++++K L H+EK K+ ++TA + D+ + + +++ +PEK
Sbjct: 275 DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329
Query: 919 ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
ES E+ + E++ K+ ++S S+ ++ + E + E DK K ++TN+
Sbjct: 330 NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383
Query: 977 HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
SS A +S + T P+K KE+++KD+
Sbjct: 384 -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438
Query: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
+I KE K KD + A P+ SS +K+ K
Sbjct: 439 GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492
Query: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
+ T R+ S D+E EKE NR+ L+ T+
Sbjct: 493 RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533
Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
+ K + ++ S + + ++ D +S+ S + +T + S +S S
Sbjct: 534 EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593
Query: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
+ + G S + + + S +DS T VT P P + S L ++ +
Sbjct: 594 TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653
Query: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
S + +S R+ +S + R + +R ST + + +++ + I
Sbjct: 654 GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713
Query: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
R T + + E KQ + EE + +TS + + +S +
Sbjct: 714 SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766
Query: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
+ +S +T+P+ + S+S Y S+ N
Sbjct: 767 QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798
Score = 37.4 bits (85), Expect = 0.15
Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)
Query: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
NM++ K+K I+ +K+ ++ EE + K ES S E++ D +
Sbjct: 307 NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366
Query: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
E E T + T+ S+ + + + + + P S IK+
Sbjct: 367 SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414
Query: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
+ E+E+K + +L L K Y E KEG+K K+
Sbjct: 415 PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463
Query: 891 TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
TA + ++ + +D K +KEK K LA + + EK+N+ S +
Sbjct: 464 TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522
Query: 942 EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
S S +G K +++ S+ +T++ +
Sbjct: 523 RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582
Query: 979 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
Q+ SS K + + + L D EK+K
Sbjct: 583 QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642
Query: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
+ER + + L ++ E + + K+ S ++ +R
Sbjct: 643 ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695
Query: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
+ + DL + + R S + E E +K KE+ ++++KE+ + E +D+
Sbjct: 696 TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754
Query: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
K K++ T + + R S+ + P ++S S S+ + + S +
Sbjct: 755 KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808
Query: 1185 SLNRSPRSENEKPG 1198
+ +R ENE+ G
Sbjct: 809 AYSRGITKENEREG 822
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 103 bits (256), Expect = 2e-21
Identities = 48/123 (39%), Positives = 76/123 (61%), Gaps = 3/123 (2%)
Query: 173 RQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYD 232
R+ K N+RN+ GET LH A I G +++V++L+ G +N +D+ GWTPLHEACN G+ +
Sbjct: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
Query: 233 VAKILIAAGA---DVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
+ + L+ GA D QG + TPLHD+ + GH ++ +LLL G + + G P++
Sbjct: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
Query: 290 VAE 292
+
Sbjct: 637 TLQ 639
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 102 bits (255), Expect = 3e-21
Identities = 62/175 (35%), Positives = 97/175 (55%), Gaps = 7/175 (4%)
Query: 141 MQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQ---KDKVNKRNERGE--TPLHMAAIR 195
+Q +++P T + + A K + +Q VN R+ G TPLH AA
Sbjct: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694
Query: 196 GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 255
V V+ L+ GA+V+ KD G PLH AC+ G+Y+VA++L+ GA VN L TPL
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754
Query: 256 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLKREVPLSD 308
H++A+ G +I KLLL+HG +P + N+ G P+D+ + + ++ LL+ + L D
Sbjct: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLD 809
Score = 99.4 bits (246), Expect = 3e-20
Identities = 53/120 (44%), Positives = 72/120 (60%)
Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
R TPLH+AA V+ V+ L+ GA+V+ KD G PLH AC+ G+Y+V ++L+ GA
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 303
VN L TPLH++AS ++ LLL HG +P N HG+ VD+A T EL L E
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
Score = 90.5 bits (223), Expect = 2e-17
Identities = 53/170 (31%), Positives = 89/170 (52%), Gaps = 5/170 (2%)
Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
+ +N R+ +G TPLH+AA +++ + L+ GA+VN +D G PLH A + G+ D+
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885
Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 293
A +LI VN TPLH++A G + LLL HG +P N+ G+ P+D+A
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Query: 294 EELELLLKREVP---LSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSL 340
+++ LL +P L + A ++P+S + + + D+L
Sbjct: 946 DDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNL 995
Score = 85.9 bits (211), Expect = 4e-16
Identities = 43/109 (39%), Positives = 66/109 (60%)
Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
R +PLH AA G V+ L+ +GANV+ +D G PLH AC+ G+ +V +L+ GAD
Sbjct: 215 RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD 274
Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
N + + TPLH++A G D+ +LL+HG +P N G+ +D+A+
Sbjct: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
Score = 64.7 bits (156), Expect = 9e-10
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 4/158 (2%)
Query: 180 KRNERGETPLH--MAAIRGDVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 236
K+ + ET LH +A++ KQV EL+ GANVN K+ TPLH A + DV ++
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
Query: 237 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
L GA +N T LH +A +GH +LLL +G +P + G + E +
Sbjct: 577 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG-NEAV 635
Query: 297 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSE 334
+ +L P+ D Y E +++ + +V + S+
Sbjct: 636 QQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673
Score = 56.6 bits (135), Expect = 2e-07
Identities = 84/342 (24%), Positives = 131/342 (38%), Gaps = 75/342 (21%)
Query: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
V+ R++ G PLH A G + V L+ GA+ N +D +TPLHEA G DV +L
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 238 IAAGADVNTQGLDDDTPLH--------------------DSASSGHRD------------ 265
+ GAD N + D + L ++A SG+ +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361
Query: 266 ----------------------IVKLLLRHGGNPFQANKHGERPVDVA----ETEELELL 299
IV+LLL+HG + +K G P+ A E ELL
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
Query: 300 LKREVPLSDDD-ESYTDSEEAQSVNPSSVDENIDSETEKDSLI-CESKQILPSKTPLPSA 357
LK ++ D +T EA S N V + S +L+ C K + P P
Sbjct: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV-DMAPTPEL 480
Query: 358 LDE--YEFKDDDDEEINKMID---DRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFK 412
+ YEFK + + D + L E +P++ +T L + +PK
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC-AVASLHPK--- 536
Query: 413 SKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDM 454
+KQ +L ++ +NK T V E +++D+
Sbjct: 537 -RKQVTELLLRKGANVNE----KNKDFMTPLHVAAERAHNDV 573
Score = 50.8 bits (120), Expect = 1e-05
Identities = 36/136 (26%), Positives = 65/136 (47%), Gaps = 6/136 (4%)
Query: 162 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 221
P +K+ R+ VN++N+ TPLH+AA R ++ L GA +N D G T
Sbjct: 535 PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Query: 222 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQAN 281
LH A G+ ++L++ G+D + L T +A G+ + ++L P + +
Sbjct: 595 LHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSE--STPIRTS 648
Query: 282 KHGERPVDVAETEELE 297
R ++ ++ +LE
Sbjct: 649 DVDYRLLEASKAGDLE 664
Score = 39.3 bits (90), Expect = 0.040
Identities = 51/196 (26%), Positives = 76/196 (38%), Gaps = 55/196 (28%)
Query: 147 DNSPDST--PNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGE--------TPLHMAAIR- 195
+NSP S+ P S ++P+ + + S + V+ G P A+R
Sbjct: 126 NNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRE 185
Query: 196 -------GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 248
GDV +VK L+ ANVN KD AG
Sbjct: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAG------------------------------ 214
Query: 249 LDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA----ETEELELLLKREV 304
+PLH +A G +D+V+ LL+ G N + G P+ A E + LLL +
Sbjct: 215 -RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA 273
Query: 305 -PLSDDDESYTDSEEA 319
P + D+ +YT EA
Sbjct: 274 DPNARDNWNYTPLHEA 289
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 102 bits (254), Expect = 4e-21
Identities = 89/418 (21%), Positives = 201/418 (48%), Gaps = 52/418 (12%)
Query: 644 DKEGKTLKKHKLKHKEREKEK--------HKKEIEGEKEKYKTKDSAKELQRSVEFDREF 695
D +G ++++ K +ER +EK K+E EK++++ +D +E QR E +RE
Sbjct: 48 DADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE- 106
Query: 696 WKENFFKSDETEDLFLNMEHESLTLEKKSKLE---------------KNIKDDKSTKEKH 740
++ + D + N + E E++++ E + +D + +E+
Sbjct: 107 -RQTDRERDRQREKERNRQKER---ERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 741 VSKERNFKEERDKIK-KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGL 799
+ER + ER++ K +E EK+ +E + ++ + E+EN D+ SE G E
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE---RGRERERER--- 216
Query: 800 HLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLD 859
E E + E++ + +E +++ K + +EK E+ E E+ + E + ++D+
Sbjct: 217 ---ETETETERKRQTDRE-RDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 860 LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKE 919
++ ++ D+ TE+ + K + ++ +R + RE+ +R+ ++E+ E++
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER-ERERERER-ERQ 330
Query: 920 RHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHI 978
R +EK K+ +Q++ + G+ + E ++ +E+ RD++S ++
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS-----ARER 385
Query: 979 QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDK 1036
+E ++ D K + + EK +D +T +E++ KD++ +R +ER + ++K
Sbjct: 386 EERERDRDRDRQKERERQ----TEKDRDGQRETEKQRERE-KDRESERGRERGREREK 438
Score = 84.7 bits (208), Expect = 8e-16
Identities = 81/354 (22%), Positives = 177/354 (50%), Gaps = 59/354 (16%)
Query: 641 KKMDKEG-KTLKKHKLKHKEREK---EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 696
++ D+E + ++++ K +EREK E+ ++E + EKE KT+D E R E +RE
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN-KTEDRHSERGRERERERETE 219
Query: 697 KENFFK--SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKI 754
E K +D D E E EK+++ E+ + ++ ++K +ER+ +RD+
Sbjct: 220 TETERKRQTDRERDRQRKTERER---EKQAERER-ASERETERDKERERERDRDRDRDRR 275
Query: 755 KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
+KE E+ D K +R T++D E E++ + +++ +
Sbjct: 276 QKERERQ------TDRKRQRR---TERDRE-----------------TERKRERQRERER 309
Query: 815 IKESKEKPEK-RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL 873
+E K E+ R + +E++ ++ + EKE++ K + ++E D+ ++ ++ +
Sbjct: 310 ERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR-------ERNRQTGRE 362
Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP-EKERHLAESKEKHLME 932
E+ +E E+ + DR+ +RE+ +R+ D+++ +KER K++
Sbjct: 363 GRRQAER-ERERERER---------DRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 933 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
+ KQ + + +SE+G+ + ++RE K+K R+++ T+ + ++ K+S++
Sbjct: 413 ETEKQREREKDRESERGRERGRERE---KQKGRERDRERQTDRQAGRQRKRSTL 463
Score = 60.1 bits (144), Expect = 2e-08
Identities = 53/279 (18%), Positives = 123/279 (44%), Gaps = 40/279 (14%)
Query: 898 DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 957
DDRE++R+K +R+ +EK + ER +E+ + EK +++++DR
Sbjct: 52 DDRERNRQK-ERERRREKRQTERETDRKRER----------------RREKDRHRKRDRH 94
Query: 958 LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK 1017
+E+ RD+E + ++ ++ + K + + E+ +D + DG+ +
Sbjct: 95 ---RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRD---RQTDGQRE 148
Query: 1018 DKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQ 1077
++ +D ++ +ER +++ Q + + E ++ K + ++ + +++ D +
Sbjct: 149 RERQRDAEKERERQTDRER-QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 1078 TSFERMLSLK-----------DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
ER + D E ++ K +E+ KQ E+ER R K +++E+
Sbjct: 208 RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERD 267
Query: 1127 KHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1165
+ + + KE R TD + + +D + R +
Sbjct: 268 RDRDRDRRQKERERQ-----TDRKRQRRTERDRETERKR 301
Score = 57.0 bits (136), Expect = 2e-07
Identities = 71/392 (18%), Positives = 161/392 (41%), Gaps = 41/392 (10%)
Query: 467 KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCS-----EKTREEGNF 521
+Q+ + K + + ++ ++ Q K+ KE R T G D E+ R+
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 522 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 581
++ D + K + E++ +Q + SE + +
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREKNRQERRERE-RQREKENKTEDRHSERGRERERE 215
Query: 582 RYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK 641
R TE+E ++ + + K + + +K E + + E + D +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 642 KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFF 701
+ ++E +T +K + + + + + K+E + E+E+ + ++ +E +R E +RE
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE------- 328
Query: 702 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK-----EKHVSKERNFKEERDKIKK 756
+ ETE + E E E+K K + + +++ + + +ER + ERD+
Sbjct: 329 RQRETE---RDREKER---ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSA 382
Query: 757 ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIK 816
+ ++ +D ++ERE T+KD + G EK+ + EK ++ +
Sbjct: 383 REREERERDRDRDRQKERER-QTEKDRD-------------GQRETEKQREREK-DRESE 427
Query: 817 ESKEKPEKRSQIK--EKDIEKMERKTFEKEKK 846
+E+ +R + K E+D E+ + +++K
Sbjct: 428 RGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 48.9 bits (115), Expect = 5e-05
Identities = 52/289 (17%), Positives = 121/289 (41%), Gaps = 53/289 (18%)
Query: 909 RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
R +E P + K+ +++ + E + ++ +E DR K+E+ R+K+
Sbjct: 30 RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDR---KRERRREKD 86
Query: 969 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK 1028
+H K +E+ +D + + + + +++D R K
Sbjct: 87 ------------------------RHRKRDRHRERQRD---REKERERQTDRERDRQREK 119
Query: 1029 ERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1088
ER++ K++ + + + E ++ + + + ++ R +++ + QT ER
Sbjct: 120 ERNRQKERER-----ETEREGERGRDRQTDGQRE-RERQRDAEKERERQTDRER------ 167
Query: 1089 LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE-VT 1147
++ E+ +QKE+ER +NR E + +++++ K TE ++ E R + E T
Sbjct: 168 -------QRQTERNRQKEREREKNRQ--ERRERERQREKENKTEDRHSERGRERERERET 218
Query: 1148 DAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
+ T+ K+ D +R + + + + S+ R E E+
Sbjct: 219 ETETERKRQTDRERDRQRKTEREREKQAERER-ASERETERDKERERER 266
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 102 bits (254), Expect = 4e-21
Identities = 154/868 (17%), Positives = 381/868 (43%), Gaps = 91/868 (10%)
Query: 297 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQI-LPSKTPLP 355
E L ++ + +E + E+ QS +E D E + + E ++ K
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 356 SALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKK 415
+ F++++++E K +LRKE+ K E E ++ ++E+ + +
Sbjct: 231 RERQDRVFQEEEEKEWRKR---ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 416 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK 475
++ E+ L+ K+ E + Q ++ +Q+ + +++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQ---------EEERREQQEERREQQERREQQEERREQQ 338
Query: 476 LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHL 535
L+ + + + Q+L++E+E E R L E+ R E R+ + + L
Sbjct: 339 LRREQEERREQQLRREQE--EERREQQLRRE-----QEEERREQQLRREQQLRREQQL-- 389
Query: 536 FHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESS 595
+ L +Q +Q+ + ++ + L R E
Sbjct: 390 ---------RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH------ 434
Query: 596 SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKL 655
KH+++ + Q+ + + K ++E E LK+ +E + + KL
Sbjct: 435 ---EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 656 KHKEREKEKHKKE-------IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
+ +ER +++ ++E E +++ K ++ + LQ+ + +++ +E +E +
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE----QEERRE 547
Query: 709 LFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK 768
L E E LE++ + ++ ++ + +++ + +E +++R +K+E E+ E+++K
Sbjct: 548 QLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQR--LKREQEERL-EQRLK 603
Query: 769 DLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI 828
+EE E + ++ E L EE L++ E E++++ ++ +E+ E+R Q
Sbjct: 604 --REEVERLEQEERRE-QRLKREEPEEERRQQLLKSEEQEERRQQQLR--REQQERREQR 658
Query: 829 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE-----CVDKIKEKDKLYSHHTEKCHK 883
+++ E+ ER E+++K EH+ E+ + +L+E ++IK + + E
Sbjct: 659 LKRE-EEEER----LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES-EA 712
Query: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 943
+ +SK + +K +E R + +++ + + E E E + H +++ +Q + +
Sbjct: 713 DARQSKVYSRPRK---QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 944 -----SKSEKGKNKEKDRE--LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 996
KSE+G+ + R +++E+ E + + EE++ + + EK
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829
Query: 997 PLSLKEKTKDEPLKTPD-----GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
L E ++E L+ + +E+D +D +R + +++ +D+ + L+ + + +
Sbjct: 830 ELQFLE--EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ-KWRWQLEEERKRRR 886
Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLR 1111
+ PA ++ KE++L+ ++ + E + E E+ +++ +E+++Q+E++ LR
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLR 945
Query: 1112 -NRNCLELKIKDKEKTKHTPTESKNKEL 1138
R + ++++ K + K ++L
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQL 973
Score = 99.0 bits (245), Expect = 4e-20
Identities = 147/896 (16%), Positives = 388/896 (43%), Gaps = 138/896 (15%)
Query: 294 EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 353
+E E + E L ++E E + + ++ + ++ + + ++ L + P
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRR-----QELERQYREEEEVQQEEEQLLREEP 1158
Query: 354 LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKS 413
E E + ++EE+ + ++ +LR+EQ K + E+ + ++E+ K +
Sbjct: 1159 EKRRRQELERQYREEEELQQ--EEEQLLREEQEKRRQ---ERERQYREEEELQRQKRKQR 1213
Query: 414 KKQKPSRV-LYSSTESSDEEALQNKKI------STSCSVIPETSNSDMQTKKEYV-VSGE 465
+ + R L E E A+++ K+ + + ++ D Q++++ + GE
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 466 HKQKGKVKRKLKNQNKNK-----ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGN 520
+++ + + + + Q +++ E E +++KE K R + + E+ R
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 521 FRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQ--- 577
+ F ++ L E++ PL+++ Q
Sbjct: 1334 TDRKFREEEQL------------------LQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 578 ----PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF 633
+R E +FL E ++ C+ +E+ Q D +F E+ ++ ++ F
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLR-CQEREQQLRQ-DRDRKFREEEQ-QLSRQERDRKF 1432
Query: 634 ENSDCTLKKMDKEGKTLKKHKLKHKEREK----------EKHKKEIEGEKEKYKTKDSAK 683
+ +++ ++E K L++ + +ER + E+ ++++ ++ K + +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 684 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 743
+L+R E DR+F +E +S E E FL E + L ++ + K +++++ + + +
Sbjct: 1493 QLRRQ-ERDRKF-REQELRSQEPERKFLEEEQQ---LHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 744 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 803
+R +++RD+ +E EE+++ +EE++ ++D +F L E
Sbjct: 1548 QR--RQDRDRKFRE------EEQLRQEREEQQLSRQERDRKF--------------RLEE 1585
Query: 804 KEIDIEKQEKHIKESKE---KPEKRSQIK-EKDIEKMERKTFEKEKKIKHEHKSEKDKLD 859
+++ ++QE+ E ++ + E + Q++ E+D + E + +E++ + H+ E+D+
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 860 LSECVD-KIKEKDKLYSH-------HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 911
L E + +E+++ H E+ +EGE +++ R++ DRK
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE------------EQQLRRQERDRKF 1693
Query: 912 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 971
+E+ + R E K ++ +Q ++ + E+ + + + +L ++E+ R
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR-----K 1748
Query: 972 ITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD 1031
I + ++ E++ L+ + +D + + ++++++ + R +E D
Sbjct: 1749 ILEEEQLRPEREEQ-------------QLRRQERDRKFREEEQLRQEREEQQL-RSQESD 1794
Query: 1032 KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD--LMQTSFERMLSLKDL 1089
+ K + L+ + E + +P+ ++ +L + L Q + + +
Sbjct: 1795 R---KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 1090 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
++ ++ ++++ Q+E+++ R E K++++ + E +++++ KS E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQER--ERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 98.6 bits (244), Expect = 6e-20
Identities = 149/782 (19%), Positives = 336/782 (42%), Gaps = 76/782 (9%)
Query: 279 QANKHGERPVDVAETEELELLLKREVPLSDDDES----YTDSEEAQSVNPSSV----DEN 330
Q + ER E EEL+ +++ +D S + E+ +V + V EN
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 331 IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ-RKEN 389
+DS + + + S+ L L E + +D + E DRH +EQ +E
Sbjct: 1248 EQFRQLEDSQLRDRQ----SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 390 EPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPET 449
+ EA++ +++EK + + K+++ + + +EE L ++
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQE----TDRKFREEEQLLQEREEQPL----RR 1355
Query: 450 SNSDMQTKKEYVVSGEHKQKGK--VKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 507
D + ++E + H+++G+ ++ + + + + +E + LK+E++ + R L
Sbjct: 1356 QERDRKFREEEL---RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-- 1410
Query: 508 GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 567
D K REE ++ + D + + L E+Q L+QE +
Sbjct: 1411 --DRDRKFREEE--QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ--LRQERHRKFR 1464
Query: 568 SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 627
+ + + +FL E ++ + K + Q+ ++ +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE-------------LRSQ 1511
Query: 628 DHSPTFENSDCTLKKMDKEGKTLKKHK-LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ 686
+ F + L + ++ K L++ + L+ +ER +++ + +E+ + + +E Q
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 687 RS-VEFDREF-WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 744
S E DR+F +E + E E F+ E + E + +L + +D K +++ + +E
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE-RDRKFREDEQLLQE 1630
Query: 745 RNFKEERDKIKKESEKSFREEKIKDLKEEREN-IPTDKDSEFTSLGMSAIEESIGLHLVE 803
R EE+ ++E ++ F EE+ + ++ERE + D+D +F E L
Sbjct: 1631 R---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF--------REEEQLLQEG 1679
Query: 804 KEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHK----SEKDK 857
+E + +QE+ K +E+ + R Q +E+ E+ + + E E+K + E + +E+++
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 858 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 917
L E KI E+++L E+ + E+ + ++ + ++ ++ D++ E
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 918 KERHLAESKEKHLMEKKNK-----QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINI 972
+E+ E +E+ L ++ + + + + E+ +E+DR+ +E+ +E
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 973 TNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK 1032
+ QEE++ + + E+ ++ + K+E G+ K ++ K R E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREE--HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGT 1917
Query: 1033 HK 1034
H+
Sbjct: 1918 HQ 1919
Score = 97.1 bits (240), Expect = 2e-19
Identities = 154/892 (17%), Positives = 374/892 (41%), Gaps = 95/892 (10%)
Query: 292 ETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSK 351
+ E E LKRE P + + SEE + + E+ E ++ L +
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 352 TPLPSALD--EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPK 409
+ E E +++ E+ + I R I + + + E+E +A ++ ++++ K +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSR-IPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 410 SFKSKKQKPSRVLYSSTESSDEEA-LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
+ +++K R +E A Q ++ + + + +S
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 469 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 528
+ + +R+L+ + + + Q E+E KE R L E+ + ++ +
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 529 DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSE---------MSLQPD 579
++ GL E Q QE + E + +P
Sbjct: 851 EEED----------------GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 580 LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 639
L E + L E + +EK + Q+ E + +++ E+ E +
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQ---ERQYREEEQLQQEEEQLLREERE-K 950
Query: 640 LKKMDKEGKTLKKHKLKHKERE---KEKHKKEIEGEKEKYKTKDSAKELQRSVEFD---- 692
++ ++E + K KL+ KE + +E K+ + ++KY+ ++ ++ + + +
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 693 --REFWKENFFKSDETEDLFLNMEHESLTLEKKSK--LEKNIKDDKSTKEKHVSKERNFK 748
R+ W+ + K DE L E E L E++ K L++ + + +E +E+
Sbjct: 1011 RRRQEWERQYRKKDE-----LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 749 EERD-KIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSA-IEESIGLHLVEKEI 806
EER+ + ++E E+ +R+E+ +L++E E + ++ + E L E+++
Sbjct: 1066 EERETRRRQELERQYRKEE--ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
E++EK ++ E+ + + +++ E++ R+ EK ++ + E + +++ +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-------EL 1176
Query: 867 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
+E+++L EK +E E+ + + E++ R+ K++ E ++ K
Sbjct: 1177 QQEEEQLLREEQEKRRQERER------------QYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 927 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
+ EK+N DN Y KG+ E+ R+L+ + RD++S + +H+ E++
Sbjct: 1225 WQWEPEKENAVRDNKVYC---KGRENEQFRQLEDSQ-LRDRQSQQ--DLQHLLGEQQ--- 1275
Query: 987 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1046
+ + ++ +++ + P + +E+ K+ K DR + +K LL+ +
Sbjct: 1276 ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK--------QLLREE 1324
Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKK---HKEKIK 1103
E + + ++ ++ + L + +R ++L ++ +K +++++
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 1104 QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
++E+ER + +L+ +++E+ + K +E + S + D +E++
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Score = 96.7 bits (239), Expect = 2e-19
Identities = 112/557 (20%), Positives = 259/557 (46%), Gaps = 66/557 (11%)
Query: 625 KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKE 684
+ E+ FE D L E + ++ + K +E+E+E + E + EK++ + +
Sbjct: 114 RQEEDQRRFEPRDRQL-----EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 685 LQRSVEFDREFWKENFFKSDETEDLFLNMEHES------LTLEKKSKLEKNIKD-DKSTK 737
+ R+ W+E + E E L HE+ L ++ LE K ++ +
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 738 EKHVSKERNFKEERDK--------IKKESEKSFREE--KIKDLKEERENIPTDKDSEFTS 787
++ ++R F+EE +K ++KE EK EE + ++L+EE E + + E
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL---RKLERQE 285
Query: 788 LGMSAIEESIGLHLVEKEIDI-----EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 842
L EE + +E + E++ + +E +E+ E+R Q +E+ +++ R+ E
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 843 -KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH---HTEKCHKEGEKSKNTAAIKKTD 898
+E++++ E + E+ + L ++ + + +L E+ + ++ + +++
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 899 ----------DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
+++ RE+ R+ +E+ +++H E +E+ L K +Q + ++ K E+
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL---KREQEERRDWLKREE 462
Query: 949 GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 1008
+ + ++E K++ RD+E ++EE++ + + Q + +E+ +++
Sbjct: 463 -ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE---QEERREQR 518
Query: 1009 LKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1068
LK + +E+ ++ ++ R++ + + Q+ LK E +K + + R +E+
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQL-----LKREEEKRLEQERREQRLKREQEE 573
Query: 1069 RLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1128
R D L++ ER E E+ + ++++K++E ERL E ++K +E
Sbjct: 574 R--RDQLLKREEERRQQRLKREQEE---RLEQRLKREEVERLEQEERREQRLKREE---- 624
Query: 1129 TPTESKNKELTRSKSSE 1145
P E + ++L +S+ E
Sbjct: 625 -PEEERRQQLLKSEEQE 640
Score = 95.9 bits (237), Expect = 4e-19
Identities = 144/906 (15%), Positives = 373/906 (41%), Gaps = 133/906 (14%)
Query: 292 ETEELELLLKREVPLSDDDESYTDSEEA---QSVNPSSVDENIDSETEKDSLICESKQIL 348
+ E E L+RE + + + EE Q + +E + + ++ + +Q+
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 349 PSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 408
+ E + + + + + LR+EQ+ E E E+ +QE+
Sbjct: 391 REQ----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER---- 442
Query: 409 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
+ + K+++ R + E ET + + +K+ + + ++
Sbjct: 443 REQRLKREQEERRDWLKREE-------------------ETERHEQERRKQQLKRDQEEE 483
Query: 469 KG----KVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKS 524
+ K++ + + + + + Q+L++E+E + R+ L ++ R E R+
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ--QRLRSEQQLRRE 541
Query: 525 FSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 584
+ + L ++ L+QE + L E Q L R +
Sbjct: 542 QEERREQLL-----------------KREEEKRLEQERREQRLKREQEERRDQL-LKREE 583
Query: 585 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 644
+ L + +++ K ++ LE E+ ++K E+ P E LK +
Sbjct: 584 ERRQQRLKREQEERL---EQRLKREEVERLEQEERREQRLKREE--PEEERRQQLLKSEE 638
Query: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
+E + ++ + + +ER +++ K+E E E+ + + K +E +R E E
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE---------- 688
Query: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDK--STKEKHVSKERNFKEERDKIKKESEKSF 762
E E ++ + + + E + + K S K + R ++E + ++ESE +
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 763 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 822
+EE+ +++ E ++ +FT + + G + + +Q + ++E+
Sbjct: 749 QEEERAHRQQQEE----EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 823 EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 882
++ + ++ EK +R+ +E++ + + E+++L E +++E++ E+
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 883 KEGEKSKNTAAIKKTDDREKSREKMDRKHD-KEKPEKERHLAESKEKHLMEKKNKQSDNS 941
+ ++ + ++R++ R + K +E+ KE+ L + +E+ L ++
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE------- 917
Query: 942 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
+EK R +++ + R++E + + ++EE++ + Q+ K L+
Sbjct: 918 ----------REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 1002 EKTKDEPLKTPDGKEKDKKDKDIDRYKERD--------------------------KHKD 1035
+K + + P+ + + +++K +Y+E + + KD
Sbjct: 968 QKEEQLLGEEPEKRRRQEREK---KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 1036 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1095
++Q L+ E +K + + ++ + +E+ + + Q E + + E+E+ +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQ----ERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080
Query: 1096 KKHKEKIKQKEKERL------RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1149
+K +E+++Q+E++ L R R E + +++E+ + + +E + + E+
Sbjct: 1081 RK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139
Query: 1150 YTKEKQ 1155
Y +E++
Sbjct: 1140 YREEEE 1145
Score = 79.0 bits (193), Expect = 5e-14
Identities = 83/515 (16%), Positives = 231/515 (44%), Gaps = 53/515 (10%)
Query: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
E ++ + K+S + +R E R F E D L E +K+ + E+
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRF---------EPRDRQLEEEPGQRRRQKRQEQERE 147
Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER-ENIPTDKDSEFTSL 788
+ + + EK E+ ++ RD+ + ++E + + +EE+ ++ + EF
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 789 GMSAIEESIGLHLV-EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI 847
E + L +E +++E+ + +E+ EK + +E + K E K E+E +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 848 KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKM 907
+ E + E+++L + E+ +L E+ ++ ++ + +++ + E+ ++
Sbjct: 268 QRELQEEEEQL-------RKLERQELRRERQEE-EQQQQRLRREQQLRRKQEEERREQQE 319
Query: 908 DRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
+R+ +E+ E++ E + + E++ +Q E + + + +++E +++E+ +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 968 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027
E + + ++ E++ + + + E+ L +++ + E ++ ++++ + R
Sbjct: 380 EQ-QLRREQQLRREQQ--LRREQQLRREQQLRREQQLRRE--------QQLRREQQLRRE 428
Query: 1028 KERDKHKDKI-QINSLLKLKSEADKPKP---KSSPASKDTRPKEKRLVNDDLMQTSFERM 1083
+E ++H+ K Q +LK E ++ + + + + + K+ + D + ER
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 1084 LSLKDLEIEQWHKKHKEKIK-------------QKEKERLRNRNCLELKIKDKEKTKHTP 1130
L L++ E + ++ +++++ Q+E+ERL+ R ++ +++ +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR------LRSEQQLRREQ 542
Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1165
E + + L R + + +++ ++ R Q
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Score = 75.5 bits (184), Expect = 5e-13
Identities = 70/438 (15%), Positives = 203/438 (46%), Gaps = 45/438 (10%)
Query: 749 EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
+E + + + ++S +++ ++ +++R P D+ +EE G +K
Sbjct: 96 DEEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQ----------LEEEPGQRRRQKR--- 141
Query: 809 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 868
++QE+ + E +E+ EK+ +++++D ++ + + + + ++ + + ++ L C
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK---- 197
Query: 869 EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
H TE+ E + + + RE+ +++ + D+ E+E +E
Sbjct: 198 ------GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 929 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS--------KHIQE 980
L +++ K + + E + +E+ R+L+++E R+++ + QE
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 981 EKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD-------GKEKDKKDKDIDRYKERDKH 1033
E++ + + Q E+ +E+ + + + + +E++++ ++ +E+++
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 1034 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
+ + Q+ +L+ E + + + R +E++L + ++ +++ + L EQ
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRRE-QQLRREQQLRREQ 429
Query: 1094 WHKKHKEKIKQKEKERLRNRNCLELK--IKDKEKTKHTPTESKNKELTRSKSSEVTDAYT 1151
++H++K +Q+ +E+ R E + +K +E+T+ E + ++L R + E + +
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 1152 K--EKQPKDAVSNRSQSV 1167
K E++ ++ R Q +
Sbjct: 490 KLEEEERREQQERREQQL 507
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 101 bits (252), Expect = 7e-21
Identities = 153/621 (24%), Positives = 250/621 (40%), Gaps = 94/621 (15%)
Query: 284 GERPVDVAETEELELLLKREVPLSDDDESYT----------DSEEAQSVNPSSVDENIDS 333
G+RP+D E EEL + KR LS ++ S Q + P ++
Sbjct: 177 GKRPLDSPEAEELPAM-KRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQD 235
Query: 334 ETEKDSLICESKQILP-SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
T+ E + P +K+ +P+A K ++ + K + K + P
Sbjct: 236 STDLAPPSPEPPMLAPVAKSQMPTA---------------KPLETKSFTPKTKTKTSSPG 280
Query: 393 AEKTHLFAKQEKAFY------PKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST---SC 443
+ Q A PK+ +K+ P R S ++ ++ K++T
Sbjct: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------SKSPKSPKSPKVTTHIPQT 333
Query: 444 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 503
V PET N +S E Q +++ N ENQ K + +
Sbjct: 334 PVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAV--------VADK 385
Query: 504 TVNTGLD------CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP 557
T+ +D C+E RE F FS ++ +F SPK G + +TP
Sbjct: 386 TIEASIDAVIARACAE--REPDPFE--FSSGSESEGDIF-----TSPKRISG--PECTTP 434
Query: 558 LKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG 617
GS+ + L DN+ + V+ K S +F
Sbjct: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS 494
Query: 618 EKSNAKIKDEDHSPTFENSDC-----TLKKMDKEGKTLKKHKLKHKEREKEKHK-KEIEG 671
+ + H E + KK+ KE KT K K K ++RE+EK K K+
Sbjct: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSK 554
Query: 672 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
EK+K K K+ KE R ++ WKE F K +E + ++ E ++ K KL+ +
Sbjct: 555 EKDKVKEKEKDKETGRETKYP---WKE-FLKEEEADPYKFKIK-EFEDVDPKVKLKDGLV 609
Query: 732 DDKSTKEKHVSKERNFKEERDKIKKESEK---SFREEKIK----DLKEERENIPTDKDSE 784
+ K K K+R K ++DK K+E EK RE+K+K L + + S
Sbjct: 610 RKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668
Query: 785 FTSLGMSAIEESIGLHLVEK------EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
T+ + A+ S+ L EK ++ ++++K KE K+K EK + KEK+ EK E+
Sbjct: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK-EK 727
Query: 839 KTFEKEKKIKHEHKSEKDKLD 859
+ EK +K K +HK EK K++
Sbjct: 728 REREKREKEKEKHKHEKIKVE 748
Score = 70.5 bits (171), Expect = 2e-11
Identities = 74/228 (32%), Positives = 102/228 (44%), Gaps = 42/228 (18%)
Query: 928 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHIQEEKKSSI 986
K M+KK KQ D EK KNK+K +E DK KEK +DKE+ E K
Sbjct: 530 KTKMKKKEKQRDRER----EKDKNKDKSKEKDKVKEKEKDKET---------GRETKYPW 576
Query: 987 VDGNKAQHEKPLSLKEKT---KDEPLKTPDGKEKDKKDKDIDRYKERD---KHKDKIQIN 1040
+ K + P K K D +K DG + +K+K D+ K+R+ K KDK +
Sbjct: 577 KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE-K 635
Query: 1041 SLLKLKSEADKPK---------------PKSSPASKDTRPKEKRLVNDDLMQTSFERMLS 1085
+K K DK K P SPA+ P + L + FE
Sbjct: 636 EKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEK 695
Query: 1086 LKDLE-----IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1128
+K+ E E+ KK KEK ++KEKER + + E + K+KEK KH
Sbjct: 696 VKEKEKKKDKKEKKKKKEKEK-EKKEKEREKEKREREKREKEKEKHKH 742
Score = 70.1 bits (170), Expect = 2e-11
Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 55/268 (20%)
Query: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 875
K +EK + S ++ K K E KT K+K+ + + + EKDK DK KEKDK+
Sbjct: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK-----DKSKEKDKV-- 559
Query: 876 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
KE EK K T K +E +E+ E + + + KE ++ K
Sbjct: 560 -------KEKEKDKETGRETKYPWKEFLKEE----------EADPYKFKIKEFEDVDPKV 602
Query: 936 KQSDNSEYSKSEKGKNKEKDRELDKKEK-SRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
K D + EK K+K+KDRE KK+K R+KE + K +++ K+
Sbjct: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV---KDKGREDKMKAP--------- 650
Query: 995 EKPLSLKEKTKDEPLKTPDGKEK-------------DKKDKDIDRYKERDKHKDKIQINS 1041
PL L K PL +P + +K ++ ++ KE++K KDK +
Sbjct: 651 APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE--- 707
Query: 1042 LLKLKSEADKPKPKSSPASKDTRPKEKR 1069
K K E +K K K K+ R +EKR
Sbjct: 708 -KKKKKEKEKEK-KEKEREKEKREREKR 733
Score = 69.3 bits (168), Expect = 4e-11
Identities = 71/250 (28%), Positives = 123/250 (49%), Gaps = 40/250 (16%)
Query: 721 EKKSKL------EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
E+K+KL +K +K + TK K K+R+ + E+DK K +KS ++K+K+ ++++
Sbjct: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK---DKSKEKDKVKEKEKDK 566
Query: 775 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDI 833
E T +++++ EE+ KE + + +K+ + EK + + K+KD
Sbjct: 567 E---TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623
Query: 834 EKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKD-KLYSHHT------------- 878
EK ++ ++EK K+K + + +K K V KE L+S T
Sbjct: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
Query: 879 ---EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
EK +E EK K KK D +EK ++K + +KEK EKER KEK EK+
Sbjct: 684 VLPEKLFEEKEKVKEKE--KKKDKKEKKKKK---EKEKEKKEKER----EKEKREREKRE 734
Query: 936 KQSDNSEYSK 945
K+ + ++ K
Sbjct: 735 KEKEKHKHEK 744
Score = 63.5 bits (153), Expect = 2e-09
Identities = 75/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)
Query: 803 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH-------EHKSEK 855
E + ++K+EK +EK + + + KEKD K + K E ++ K+ E +++
Sbjct: 528 ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587
Query: 856 DKLDLSECVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHD 912
K + E D K+K KD L EK HK+ +K + K D REK + K + D
Sbjct: 588 YKFKIKEFEDVDPKVKLKDGLVRKEKEK-HKDKKKDREKGK-KDKDKREKEKVKDKGRED 645
Query: 913 KEK--------PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 964
K K P KE L + + KEK +E +KK+
Sbjct: 646 KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705
Query: 965 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDI 1024
++K+ K ++EKK + K + EK KEK K E +K I
Sbjct: 706 KEKK-----KKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE--PVALAPSPVI 758
Query: 1025 DRYKER-DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1066
R R +DKI I+ ++ P P++ PA RPK
Sbjct: 759 PRLTLRVGAGQDKIVISKVV--------PAPEAKPAPSQNRPK 793
Score = 39.7 bits (91), Expect = 0.031
Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 14/221 (6%)
Query: 1056 SSPASKDTRPKEKRLVNDDL--MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1113
SSP+ P+ V ++ + +S E LK + KK K++ +++EK++ +++
Sbjct: 493 SSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK 552
Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVM 1173
+ + K+K+KEK K T E+K K E K K+ +D VD K +
Sbjct: 553 SKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED--------VDPKVKL 604
Query: 1174 TLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDF 1233
G + ++ E K R + ED + P PP+
Sbjct: 605 KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK----MKAPAPPLVLPPKE 660
Query: 1234 MLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIK 1274
+ S + S+ P + + P L E+ + + E+ K
Sbjct: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
Score = 39.3 bits (90), Expect = 0.040
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 991 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1050
K + + +K+K K E LKT + KK+K DR +E+DK+KDK + +
Sbjct: 512 KTKLPSSVEVKKKLKKE-LKT----KMKKKEKQRDREREKDKNKDKSK-----------E 555
Query: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
K K K K+T +T + LK+ E + + K KE K +L
Sbjct: 556 KDKVKEKEKDKETG-----------RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
Query: 1111 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
++ + K K K+K K K+K+ + + +V D ++K A
Sbjct: 605 KDGLVRKEKEKHKDKKKDREKGKKDKD--KREKEKVKDKGREDKMKAPA 651
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 100 bits (250), Expect = 1e-20
Identities = 53/127 (41%), Positives = 79/127 (62%), Gaps = 2/127 (1%)
Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
R TPLH AA V V+ L+ GA+V+ KD G PLH AC+ G+Y+VA++L+ GA
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLK 301
VN L TPLH++A+ G +I KLLL+HG +P + N+ G P+D+ + + ++ LL+
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLR 644
Query: 302 REVPLSD 308
+ L D
Sbjct: 645 GDAALLD 651
Score = 93.2 bits (230), Expect = 2e-18
Identities = 51/134 (38%), Positives = 76/134 (56%), Gaps = 2/134 (1%)
Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
D VN R+ +G TPLH+AA +++ + L+ GA+VN +D G PLH A + G+ DV
Sbjct: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 293
A +LI A VN TPLH++A G + LLL HG +P N+ G+ P+D+
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Query: 294 EELELLLKREVPLS 307
+++ LL +P S
Sbjct: 788 DDVSALLTAAMPPS 801
Score = 92.0 bits (227), Expect = 5e-18
Identities = 49/120 (40%), Positives = 71/120 (59%)
Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
R TPLH+AA VK V+ L+ GA+V+ KD PLH AC+ G+Y+V ++L+ GA
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 303
VN L TPLH++AS ++ LLL +G +P N H + +D+A T +L+ L E
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329
Score = 87.4 bits (215), Expect = 1e-16
Identities = 48/119 (40%), Positives = 68/119 (57%), Gaps = 2/119 (1%)
Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
+KVN R+ G TPLH AA G V+ L+ GANV +D G PLH AC+ G+ +V
Sbjct: 47 EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106
Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
+L+ GAD N + + TPLH++A G D+ +LL+HG P N G +D+A+
Sbjct: 107 VNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Score = 63.5 bits (153), Expect = 2e-09
Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 1/93 (1%)
Query: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
V+ +++ G PLH A G + + L+ GA VNV D +TPLHEA G Y++ K+L
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 238 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
+ GAD + D +TPL D G DI LL
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLL 643
Score = 54.3 bits (129), Expect = 1e-06
Identities = 46/148 (31%), Positives = 70/148 (47%), Gaps = 6/148 (4%)
Query: 180 KRNERGETPLHMAAIRG--DVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 236
K + ET LH AA KQ+ EL+ GAN+N K TPLH A + DV ++
Sbjct: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
Query: 237 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
++ A VN T LH +A GH +LLL +G +P + G + + E +
Sbjct: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-NENV 477
Query: 297 ELLLKREVPL--SDDDESYTDSEEAQSV 322
+ LL+ + L S+ D ++ +A V
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDV 505
Score = 53.9 bits (128), Expect = 2e-06
Identities = 28/86 (32%), Positives = 44/86 (51%)
Query: 189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 248
L A + K + L L N + D TPLH A + ++L+ GADV+ +
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241
Query: 249 LDDDTPLHDSASSGHRDIVKLLLRHG 274
D PLH++ S GH ++ +LL++HG
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHG 267
Score = 48.1 bits (113), Expect = 9e-05
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 132 SERKQMALLMQMTARDNSPD---STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETP 188
+E K MALL + ++ D STP H + K D V+ +++ P
Sbjct: 189 NEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD-VHAKDKGDLVP 247
Query: 189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
LH A G + + L+ GA VN D +TPLHEA + +V +L++ GAD
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Score = 46.6 bits (109), Expect = 3e-04
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 4/109 (3%)
Query: 162 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 221
P +K+ R+ +N++ + TPLH+A+ + V+ ++ A VN D G T
Sbjct: 377 PKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436
Query: 222 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
LH A G+ ++L++ G D N L T L G+ ++ +LL
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL----QMGNENVQQLL 481
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 100 bits (248), Expect = 2e-20
Identities = 132/577 (22%), Positives = 233/577 (40%), Gaps = 79/577 (13%)
Query: 547 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 606
SCG +S K+E + S SS S D + S+ S+ + K K
Sbjct: 173 SCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKK 232
Query: 607 KHQKDFHLEFGEKSNAK----------------------IKDEDHSPTFENSDCTLKKMD 644
KH+K+ EK K ++ E+ P EN K
Sbjct: 233 KHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPP 292
Query: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ----RSVEFDREFWKENF 700
K + +K++ + +ERE + + + S ++++ R +
Sbjct: 293 KADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352
Query: 701 FKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKS----TKEKHVS----KERNFKEERD 752
F+ ET + E + + S E+ IK DKS KE S KER + R+
Sbjct: 353 FRRSETPPHW-RQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRN 411
Query: 753 KIKKESEKSFREEKIKDLK---EERE-NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
+ + K+ +E+K+KD K +ER+ ++KD ++ + + EK
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 809 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS---EKDKLDLSECVD 865
E+ KH E+ RS+ K +D E ++ K + + K K + +S EK K S+ +
Sbjct: 472 ERDSKH--NRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNE 529
Query: 866 ----KIKEKDKLYSHHTEKCH-KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKER 920
K KEKD+ + +C +G+ S N+ +++ R++SR R HD+++
Sbjct: 530 HDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDR----- 584
Query: 921 HLAESKEKHL---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE--KSRDKESINITNS 975
+ SKE H E + + S ++ G+++ KDR +++ S +ES +
Sbjct: 585 --SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKD 642
Query: 976 KHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGKEKDKKDKDIDRY-KERD 1031
K+ +E KSS H K S EK +K + + + K D+D + K +
Sbjct: 643 KYRNQESKSS--------HRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQ 694
Query: 1032 KHKDKIQINSLL------KLKSEADKPKPKSSPASKD 1062
+D +S+L K++S +K KS D
Sbjct: 695 SSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEND 731
Score = 99.4 bits (246), Expect = 3e-20
Identities = 129/630 (20%), Positives = 260/630 (41%), Gaps = 69/630 (10%)
Query: 408 PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 467
PKS K KK++ R SS+ SS + S S S ++S+S+ T +
Sbjct: 179 PKS-KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSS---DSSDSESAT----------E 224
Query: 468 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 527
+K K ++K +N K +E K+ K+ K++ SE E + + P
Sbjct: 225 EKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSE----------SEAENLEAQPQSTVRP 274
Query: 528 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE 587
++ + KSP + EK+ ++E + C P S S Q L+
Sbjct: 275 EEIPPIPENRFLMRKSPPKA---DEKERKNRERERERECNPPNSQPASYQRRLL------ 325
Query: 588 SEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
V K K + + + +S + + + P + +E
Sbjct: 326 ---------VTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWR----------QEM 366
Query: 648 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 707
+ ++ ++ ER + K E+ KE ++ KE + + D E+ + +E E
Sbjct: 367 QRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKIT---DHRNVSESPNRKNEKE 423
Query: 708 DLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEK 766
+ + S + + EK+ K K++ SK R+ +E+ K K+ K R EEK
Sbjct: 424 KKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEK 483
Query: 767 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 826
+ + + K+ E S +E K+++ + E +SKEK ++R+
Sbjct: 484 RMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEK-DRRA 542
Query: 827 QIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE 886
Q + ++ + + K + + ++ + S D+ + + K Y + E+ ++
Sbjct: 543 QSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRG 602
Query: 887 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 946
+S++ + R +S+++ R+ D E+E + +K+K+ +++K S E S+S
Sbjct: 603 RSRSRER-RTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKY-RNQESKSSHRKENSES 660
Query: 947 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD 1006
EK + K R+ + SR+K K +++ S + + +E S+ + +D
Sbjct: 661 EK-RMYSKSRDHNSSNNSREK--------KADRDQSPFSKIKQSSQDNELKSSMLKNKED 711
Query: 1007 EPLKTPDGKEKDK-KDKDIDRYKERDKHKD 1035
E +++ KE K K ++ D E++K D
Sbjct: 712 EKIRSSVEKENQKSKGQENDHVHEKNKKFD 741
Score = 72.8 bits (177), Expect = 3e-12
Identities = 121/637 (18%), Positives = 245/637 (38%), Gaps = 95/637 (14%)
Query: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
KR S S +DS+ + SS + +S TE+ S + K S+
Sbjct: 189 KRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSR--------- 239
Query: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
+ K + + RK+ +K E+E +L A+ + P+ +
Sbjct: 240 -KHKKEKKK------------RKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPEN-RF 285
Query: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
++ S +DE+ +N++ P S ++ V K KG+ R+ + +
Sbjct: 286 LMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPS 345
Query: 481 KNKENQELKQEKE----GKENTRITNLTVNTGL-----DCSEKTREEGNFRKSFSPKDDT 531
+++ ++ + +E R + V++G D SE + N R K+
Sbjct: 346 RSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK 405
Query: 532 SLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFL 591
H + +SP K E K S+ S + D+ R N+E +
Sbjct: 406 ITD--HRNVSESPNR------------KNEKEKKVKDHKSN--SKERDIRR--NSEKDDK 447
Query: 592 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
++ K K K +SK + EKS +K +D H+ E K+M K
Sbjct: 448 YKNKVKKRAKSKSRSKSK--------EKSKSKERDSKHNRNEE------KRMRSRSKGRD 493
Query: 652 KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFL 711
+K KE++ + K ++E+ ++K+ +K+L+ KS+E +
Sbjct: 494 HENVKEKEKQSDSKGK----DQERSRSKEKSKQLES--------------KSNEHD---- 531
Query: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
S + EK + + ++ TK KH R + R + + +S ++ +
Sbjct: 532 ----HSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRS 587
Query: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
+E ++ E+ G S E + D ++ + S E+ E +S+ K+K
Sbjct: 588 KEYHRY---REQEYRRRGRSRSRERRTPPGRSRSKD-RRRRRRDSRSSEREESQSRNKDK 643
Query: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNT 891
+ + + KE + K + S + K+ D+ S + K + + ++
Sbjct: 644 YRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFS-KIKQSSQDNELK 702
Query: 892 AAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
+++ K + EK R +++++ K K ++ H+ E +K
Sbjct: 703 SSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739
Score = 65.1 bits (157), Expect = 7e-10
Identities = 94/451 (20%), Positives = 184/451 (40%), Gaps = 83/451 (18%)
Query: 751 RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 810
+ K+KKE +K K + + DS+ +S S+ + S E EK
Sbjct: 180 KSKVKKEEKKRH--------KSSSSSSSSSSDSDSSSDSQSSSDSSDSESATE-----EK 226
Query: 811 QEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEK 870
+K ++ K + R KEK K +K+ E + ++ + + E + I E
Sbjct: 227 SKK--RKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEE-IPPIPEN 283
Query: 871 DKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHL 930
L KS A K+ +RE+ RE+ + + +R L ++
Sbjct: 284 RFLM-----------RKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSG-- 330
Query: 931 MEKKNKQSDNSEYSKSEKGKNKEKDR----------ELDKKEKSR----------DKESI 970
+K K Y + +++++ R E+ + ++ R DK +
Sbjct: 331 --RKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSEL 388
Query: 971 NITNSKHIQEEKKSSI-VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1029
N I+E ++S + V K + +S K+E K + + K++DI R E
Sbjct: 389 N-----EIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443
Query: 1030 RD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1088
+D K+K+K++ + K +S++ + SK R +EKR+ +
Sbjct: 444 KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM----------------RS 487
Query: 1089 LEIEQWHKKHKEKIKQ---KEKERLRNRNCLELKIKDKEKTKHTPTESKNKE---LTRSK 1142
+ H+ KEK KQ K K++ R+R+ + K + + +H ++SK K+ +RS+
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Query: 1143 SSEVT---DAYTKEKQPKDAVSNRSQSVDTK 1170
++T +Y + + +RS+ V ++
Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSRRVRSR 578
Score = 61.6 bits (148), Expect = 8e-09
Identities = 78/380 (20%), Positives = 156/380 (41%), Gaps = 45/380 (11%)
Query: 829 KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD-------KIKEKDKLYSHHTEKC 881
K K EK K+ + S D S+ D K K++ K + ++ K
Sbjct: 182 KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKH 241
Query: 882 HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE-KPEKERHLAESKEKHLMEKKNKQSDN 940
KE +K K + KK+ E E ++ + +PE+ + E++ LM K ++D
Sbjct: 242 KKEKKKRKKS---KKSASSESEAENLEAQPQSTVRPEEIPPIPENR--FLMRKSPPKADE 296
Query: 941 SEYSKSEKGKNKEKDRELDKKEK-----------SRDKESINITNSKHIQEEKKSSIVDG 989
E K + +E++RE + +R I + + +S D
Sbjct: 297 KE----RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352
Query: 990 NKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-DIDRYKERDKHKDKIQINSLLKLKSE 1048
+ P +E + + ++ G+ K DK +++ KE + +++ + ++
Sbjct: 353 FRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNV 412
Query: 1049 ADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
++ P K+ KEK++ D S ER + + + K+K K+K++ K
Sbjct: 413 SESPNRKNE--------KEKKV--KDHKSNSKERDIRRNSEKDD----KYKNKVKKRAKS 458
Query: 1109 RLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1168
+ R+++ + K K+++ +KH E K +RSK + + KEKQ ++ +S
Sbjct: 459 KSRSKSKEKSKSKERD-SKHNRNEEKRMR-SRSKGRDHENVKEKEKQSDSKGKDQERSRS 516
Query: 1169 TKNVMTLGKSSFVSDNSLNR 1188
+ L S D+S ++
Sbjct: 517 KEKSKQLESKSNEHDHSKSK 536
Score = 48.5 bits (114), Expect = 7e-05
Identities = 74/355 (20%), Positives = 130/355 (36%), Gaps = 42/355 (11%)
Query: 355 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 414
P+ +E E K D + +K D R K+ + +N+ + ++A KSK
Sbjct: 416 PNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK----------KRAKSKSRSKSK 465
Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
++ S+ S ++E+ ++++ + E K+ + + + K K
Sbjct: 466 EKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKD-----QERSRSKEKS 520
Query: 475 KLKNQNKNKENQELKQEKEGKENTRITNLTVNTGL-DCSEKTREEGNFR------KSFSP 527
K N+ + +EK+ + +R + G + +TRE R +S +
Sbjct: 521 KQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580
Query: 528 KDDTS----LHLF----HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPD 579
D S H + + G+S +S + + E S +
Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRN 640
Query: 580 LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 639
+Y N ES +SS K EK + K S K D D SP +
Sbjct: 641 KDKYRNQES----KSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSP------FS 690
Query: 640 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE 694
K + LK LK+KE EK + E E +K K + D E ++ +FD E
Sbjct: 691 KIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE--KNKKFDHE 743
Score = 36.2 bits (82), Expect = 0.34
Identities = 31/141 (21%), Positives = 52/141 (36%), Gaps = 6/141 (4%)
Query: 48 VSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPE 107
+ K +K KR + S S + + DS +DS S + + +K
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237
Query: 108 KKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKT 167
+K KKE +K + S SE + + Q T R P+ P P +K
Sbjct: 238 SRKHKKEKKKRKKSKKS---ASSESEAENLEAQPQSTVR---PEEIPPIPENRFLMRKSP 291
Query: 168 PSSSSRQKDKVNKRNERGETP 188
P + +++ + ER P
Sbjct: 292 PKADEKERKNRERERERECNP 312
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 99.8 bits (247), Expect = 3e-20
Identities = 145/664 (21%), Positives = 269/664 (40%), Gaps = 103/664 (15%)
Query: 542 KSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD----------NTESEFL 591
+ P+ S G +K+ KQ+ + + E+SL+ ++ D N E EF
Sbjct: 35 QEPQKSKGKKKKEKK--KQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 592 PESSSVKSCKHKEKSKHQKDFH----LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
+ K K K++S D + K AK K E +S + ++ D +G
Sbjct: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
Query: 648 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEF--DREFWKENFFKSDE 705
K K +K E E + K+I KE+ + S + S EF R+ K+N
Sbjct: 153 KAQKSNKKWDGSEEDEDNSKKI---KERSRINSSGESGDESDEFLQSRKGQKKN------ 203
Query: 706 TEDLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEK 760
+K+K NI+ DD S K K V++++ K+ER++ K++ EK
Sbjct: 204 ----------------QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247
Query: 761 SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI--EKQEKHIKES 818
+ K++ LKE+ E KD EE V + + +EK +
Sbjct: 248 A----KLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 819 KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
+ + K+KD +K + + EKEK+ K + S+ + E + K+KE+++
Sbjct: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKE-KKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK--EKHLMEKKNK 936
E+ K E+ + K+ ++ +EK +RK KEK KER E K K E + +
Sbjct: 363 EERIKRLEELE----AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
Query: 937 QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 996
+ +++ + KD K+ DK+ I +E +S + E+
Sbjct: 419 AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ 478
Query: 997 PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK--ERDKHKDKIQINSL-LKLKSEADKPK 1053
+ KE+T P +E+D +D +D ++ D+ +K++ N + +++K ++ +
Sbjct: 479 GVPEKEET---PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535
Query: 1054 PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1113
+ +D +E+ E E+ + E ++ E
Sbjct: 536 EEEEEEEEDEESEEE---------------------EEEEGESEGSEGDEEDE------- 567
Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQS---VDTK 1170
K+ D++ + T + +KE++ + D TKE++ D R + +K
Sbjct: 568 -----KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
Query: 1171 NVMT 1174
NV T
Sbjct: 623 NVNT 626
Score = 94.0 bits (232), Expect = 1e-18
Identities = 142/619 (22%), Positives = 259/619 (41%), Gaps = 108/619 (17%)
Query: 623 KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSA 682
K K ED + + D +++ G K +E +K K KK+ E +K+ + D
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAA------KEQEPQKSKGKKKKEKKKQDFDEDDIL 59
Query: 683 KELQ------RSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK----- 731
KEL+ + ++ DRE TE N E E + +KK K +K K
Sbjct: 60 KELEELSLEAQGIKADRE-----TVAVKPTE----NNEEEFTSKDKKKKGQKGKKQSFDD 110
Query: 732 ------DDKSTKEKHVSKER-----------NFKEERDKIKKESEKSFR--------EEK 766
+DK +K K +K + +F + K K +++KS + E+
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 767 IKDLKEERENIPT-----DKDSEFTSL--------------GMSAIEESIGLHLVEKEID 807
K +K ER I + D+ EF + + E K +
Sbjct: 171 SKKIK-ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA 229
Query: 808 IEKQEKHIKESKEKPEKRSQIKE-KDIEKMER----KTFEKEKKIKHEHKSEKDKLDLSE 862
+K EK +E K++ E+++++++ K+ E++E ++ +KE + K E ++ K K+ +
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289
Query: 863 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK-----------MDRKH 911
V E +K + + EG+K K KK + EK +EK M
Sbjct: 290 GVIPASE-EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
Query: 912 DKEKPEKERHLAESKEK----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
K K E+ER E +E+ +E K K+ + E K E+ K KEK+R KE+ + K
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER----KERLK-K 403
Query: 968 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027
E +T S+ + + + +AQ + S K P+ +DKK K I +
Sbjct: 404 EGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPI------YEDKKRKKIPQQ 457
Query: 1028 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1087
E + + +++ + +++ + K ++ P P+E+ +D +E M S +
Sbjct: 458 LESKEVSESMELCAAVEVMEQGVPEKEETPP---PVEPEEEE-DTEDAGLDDWEAMASDE 513
Query: 1088 DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE-SKNKELTRSKSSEV 1146
+ E + +K H E + E+E E + ++E+ + +E S+ E S E
Sbjct: 514 ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 1147 TDAYTKEKQPKDAVSNRSQ 1165
T +K+P +S+ S+
Sbjct: 574 DSGKTLDKKPSKEMSSDSE 592
Score = 87.4 bits (215), Expect = 1e-16
Identities = 155/658 (23%), Positives = 272/658 (41%), Gaps = 111/658 (16%)
Query: 360 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 419
E + +D D+++I K +++ + + + + E A K E+ F K K K QK
Sbjct: 47 EKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT--ENNEEEFTSKDKKKKGQKGK 104
Query: 420 RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 479
+ + +S + E +K T+ + S SD + K KGK ++ K
Sbjct: 105 KQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPK---KAKGKAQKSNKKW 161
Query: 480 NKNKENQELKQEKEGKENTRITN-----------LTVNTGLDCSEKTREEGNFRKSFSPK 528
+ ++E+++ K+ KE +RI + L G ++K + N +S +
Sbjct: 162 DGSEEDED--NSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI-ESGNED 218
Query: 529 DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTES 588
DD S + ++ K+ K K+ K++ K L
Sbjct: 219 DDASFKIKTVAQKKAEK-------KERERKKRDEEKAKLRK------------------- 252
Query: 589 EFLPESSSVKSCKHKEKSKHQKDFHLEFGEKS-NAKIK-DEDHSPTFENS--DCTLKKMD 644
L E +++ K K++SK QK+ +F E++ +K+ D P E T + D
Sbjct: 253 --LKEKEELETGK-KDQSK-QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD 308
Query: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
EG KK K K K ++EK K EK+K +K + K +Q ++ +E E +
Sbjct: 309 NEGDKKKKDKKKKKGEKEEKEK-----EKKKGPSKATVKAMQEALAKLKE---EEERQKR 360
Query: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 764
E E+ +E +++ +LE+ ++ K KEK KER KE + K + E R
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE-RKERLKKEGKLLTKSQREARARA 419
Query: 765 EK-IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 823
E +K L+ + +P+ KDS + I K+I + + K + ES E
Sbjct: 420 EATLKLLQAQGVEVPS-KDS-------LPKKRPIYEDKKRKKIPQQLESKEVSESMELCA 471
Query: 824 KRSQIKEKDIEKMERKTFEKEK-----KIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
+E ME+ EKE+ + + E +E LD E + +E +K+ +
Sbjct: 472 A--------VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGN-- 521
Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
K H E K + E+ E+ + + D+E E+E ES+ E+ K S
Sbjct: 522 -KVHIE----------VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570
Query: 939 DNSEYSKS---EKGKNKEKDRELD------KKEKSRDK-----ESINITNSKHIQEEK 982
D + K+ + K D E D K+E++ DK E + +SK++ EK
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
Score = 65.1 bits (157), Expect = 7e-10
Identities = 132/644 (20%), Positives = 249/644 (38%), Gaps = 69/644 (10%)
Query: 305 PLSDDDESYTDSEE---AQSVNPSSVDENIDSETE-KDSLICESKQILPSKTPLPSALDE 360
P +++E +T ++ Q S D+N E E KDS +SK+ K + S D
Sbjct: 83 PTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS---KSKKTAKPKVEMYSGSD- 138
Query: 361 YEFKDDDD------------EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 408
DDDD ++ NK D +K E + + E +
Sbjct: 139 ----DDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 409 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVS-GEHK 467
+S K +K+ + ES +E+ + KI T E + + + E + K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254
Query: 468 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG-LDCSEKTREEGNFRKSFS 526
+K +++ K+Q+K KE+Q ++ +E T + +TV+TG + SE+ E + +
Sbjct: 255 EKEELETGKKDQSKQKESQ-----RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309
Query: 527 PKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMS-LQPDLVRYDN 585
D K K G E++ K+ +K + ++ L+ + R
Sbjct: 310 EGDKKK---------KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Query: 586 TESEFLPESSSVKSCKHKEKS--------KHQKDFHLEFGEKSNAKIKDEDHSPTFENSD 637
E E + +++ + +E+ K QK+ + K K+ + ++
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
Query: 638 CTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR--EF 695
TLK + +G + K+R + KK ++K + +KE+ S+E E
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKK-----RKKIPQQLESKEVSESMELCAAVEV 475
Query: 696 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK 755
++ + +ET E E E D+++ K V + E ++ +
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEK---VEGNKVHIEVKENPE 532
Query: 756 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 815
+E E+ EE+ ++ +EE E + SE +E ++K+ E
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Query: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD--KIKEKDKL 873
+S + K + +K ++E++ E K + E K + + VD K K DKL
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTE-KLRAPIICVLGHVDTGKTKILDKL 651
Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTD---DREKSREKMDRKHDKE 914
H + +GE T I T+ + + KM + D+E
Sbjct: 652 RHTHVQ----DGEAGGITQQIGATNVPLEAINEQTKMIKNFDRE 691
Score = 56.6 bits (135), Expect = 2e-07
Identities = 93/537 (17%), Positives = 204/537 (37%), Gaps = 67/537 (12%)
Query: 258 SASSGHRDIVKLLLRHGGNPFQANKH---GERPVDVAETEELELLLKREVPLSDDDESYT 314
S S D KL + G ++NK E D ++ + + D+ + +
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 315 DSEEAQSVNPSSVD-ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINK 373
S + Q N + NI+S E D + K + K E + +D++ ++ K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER--ERKKRDEEKAKLRK 252
Query: 374 MIDDRHI--------LRKEQRKENEPEAEKTHLF-------AKQEKAFYPKSFKSKKQKP 418
+ + + +KE +++ E E K+ + A +EKA P + + +
Sbjct: 253 LKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGD 312
Query: 419 SRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKN 478
+ + ++E + +K + + KE + +++ ++KR +
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL 372
Query: 479 QNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF----RKSFSPKDDTSLH 534
+ K KE + L+QEK ++ + + E+ ++EG ++ + + +L
Sbjct: 373 EAKRKEEERLEQEKRERKKQK--------EKERKERLKKEGKLLTKSQREARARAEATLK 424
Query: 535 LFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 594
L + P L +K+ ++ K S E+S +L + +PE
Sbjct: 425 LLQAQGVEVPSKD-SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
Query: 595 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHK 654
E+ + +D L+ D D+E + ++ +K
Sbjct: 484 EETPPPVEPEEEEDTEDAGLD---------------------DWEAMASDEETEKVEGNK 522
Query: 655 LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME 714
+ + +E + ++E E E+E E + S E + E + + DE ++ + +
Sbjct: 523 VHIEVKENPEEEEEEEEEEE---------EDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 715 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK---ESEKSFREEKIK 768
TL+KK E + + + + +ER + + + +I+K E K+ EK++
Sbjct: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
Score = 43.5 bits (101), Expect = 0.002
Identities = 118/647 (18%), Positives = 228/647 (35%), Gaps = 77/647 (11%)
Query: 28 RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
+KSK K K + D+ KE++E S + + +D ++ +E
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGI------------KADRETVAVKPTE 85
Query: 88 NWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARD 147
N E S + +K+G + KK + + + L +K ++M +
Sbjct: 86 NNEEEFTSKDK---KKKGQKGKKQSFDDNDSEE-----LEDKDSKSKKTAKPKVEMYSGS 137
Query: 148 NSPDSTPNHPSQTT-PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
+ D P + AQK ++D+ N + + + ++ + GD
Sbjct: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
Query: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
G N K+ G P E+ N D A I A + + + D + R +
Sbjct: 198 KGQKKNQKNKPG--PNIESGNED--DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
Query: 267 -VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPS 325
K L G K +R + + + +P S++ + E +
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 326 SVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ 385
+ + EK+ E K+ PSK + A+ E K ++EE K ++ I R E+
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKK-GPSKATV-KAMQEALAKLKEEEERQKREEEERIKRLEE 371
Query: 386 RKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
+ E E+ ++ K K K + +K ++L S + A K+ + V
Sbjct: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
Query: 446 IPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQEL-------------KQEK 492
E + D KK + E K++ K+ ++L+++ + E+ EL K+E
Sbjct: 432 --EVPSKDSLPKKRPIY--EDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486
Query: 493 EGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSE 552
T + GLD E + K K HI ++P+ E
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK-------VHIEVKENPEEEEEEEE 539
Query: 553 KQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDF 612
++ + E E E ES + + EK +KD
Sbjct: 540 EEEEDEESEE------------------------EEEEEGESEGSEGDEEDEKVSDEKDS 575
Query: 613 HLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
+K + ++ + + ++ + DK + ++K +L+H +
Sbjct: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 99.4 bits (246), Expect = 3e-20
Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)
Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 335
NP +N E V E ++L + ++++ + D S D+ + + S E +D +
Sbjct: 633 NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 691
Query: 336 EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 395
+ D ++ K++ S + D D EI+ + L+ + K+++ + ++
Sbjct: 692 DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 743
Query: 396 THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 452
+ + F K KS K + + +ESS+ ++ K+I + + T+
Sbjct: 744 KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 801
Query: 453 DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 503
+ K++ S + H +KG + KN Q + ++ E KQE+E E T +
Sbjct: 802 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 861
Query: 504 TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 548
T+ D K ++ +G + S + TSL + H+ T K
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 921
Query: 549 GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 591
GLS+ LK++ + K G+ E D + Y+++ +E L
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 592 PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
PE + KS K ++K+ +KD ++ EKS K D S
Sbjct: 982 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041
Query: 633 FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 675
++ + + K K L K K ++ +K K IE E+
Sbjct: 1042 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1101
Query: 676 YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 729
+K + KE+Q SD E N + + T KK K +
Sbjct: 1102 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1150
Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 788
++ K+ ++ + E D E S E+KIK + E N+ + F S
Sbjct: 1151 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1207
Query: 789 GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 824
G A+ +S+ + + + + D + + + K E K++ K
Sbjct: 1208 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1267
Query: 825 RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
+++ D E + E + KK ++ H+ + KL +S+ ++K K H
Sbjct: 1268 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327
Query: 879 EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
K K + + +++ E+ E D + + + K+ L E++ + +KK
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1387
Query: 936 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
++ E S SE N E++ E ++E+ ++E +EE++ D +K+ +
Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1437
Query: 996 KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
+++ KD+ L+T ++++ R ER++ ++K L+ E + P
Sbjct: 1438 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1491
Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1092
P + E + L+Q ++ LK +++
Sbjct: 1492 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1528
Score = 55.8 bits (133), Expect = 4e-07
Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)
Query: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
++K KL + + S+ K + + + E K K+F+ + D+K+ +
Sbjct: 315 IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 373
Query: 780 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 839
D +SEF ++ E++ H K ID + + K K EK +++KDI K E K
Sbjct: 374 DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 425
Query: 840 TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 896
K+ +H H+ +E+ + + S + K+ D+ E + + + ++
Sbjct: 426 LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 484
Query: 897 T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 942
+ ++ E + E +D + D ++ + S + ++ K N+ S+
Sbjct: 485 SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 544
Query: 943 ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 981
Y K + + + D +E +DK+ ++++H+ E
Sbjct: 545 TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604
Query: 982 KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1041
+ S +++ E L + K PL+ P + D + E K K K+ +
Sbjct: 605 EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 657
Query: 1042 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1092
K K S D PKP P SK + ++ +D+++ + S S D +I
Sbjct: 658 RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 717
Query: 1093 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1144
+ H HK K +K + + ++ D +K K + SK K T+S+SS
Sbjct: 718 EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 777
Query: 1145 EVTDAYTKE 1153
KE
Sbjct: 778 NYDSELEKE 786
Score = 39.3 bits (90), Expect = 0.040
Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)
Query: 744 ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 801
E+ ++ + KIK +SEKS + E + ++ + ++ + ++ S +
Sbjct: 250 EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 309
Query: 802 VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 856
V KE+ I+K +K I+ + + ++ + E + K +++K KS +K
Sbjct: 310 VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 367
Query: 857 KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 907
L L E ++ + + D + K HK + K + A++K D KS K+
Sbjct: 368 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 426
Query: 908 DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 965
RK D E + E + ++K+SD E + E N +D ++D S
Sbjct: 427 SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 485
Query: 966 DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 1004
E I N+ + +Q +E +SS V N + + +K KT
Sbjct: 486 VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 545
Query: 1005 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1037
+ P+K D +E +DKD + + ++H +
Sbjct: 546 KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604
Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1096
+++ LL+ P+ K++P RP E V + + E + + L + K
Sbjct: 605 EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 661
Query: 1097 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1143
K + K K+ E + +N + E+ KE ++ + + S + ++ +
Sbjct: 662 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 721
Query: 1144 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
+ T K + KD R + DTK + KSS +S S N
Sbjct: 722 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 780
Query: 1197 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1255
L SM + ++ T R P D D + S+ ++ S
Sbjct: 781 SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 834
Query: 1256 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1303
ERE S A+ + +RL S+S + V + + +
Sbjct: 835 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894
Query: 1304 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1363
++EVR+ + E +K +T + + Q L S++ E+ L
Sbjct: 895 SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 933
Query: 1364 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1421
S TS SK + ++ +PS + + + +E
Sbjct: 934 --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 973
Query: 1422 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1473
D E L R+ IC + P +++ K K+ D S ++ EL
Sbjct: 974 SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1030
Query: 1474 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1526
G+SC ++D S + ++ C +S + S + Y + +E G
Sbjct: 1031 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1089
Query: 1527 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1586
++ I + S ++T+ + +DA + ++ + + +KA V+
Sbjct: 1090 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1143
Query: 1587 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1643
EK N ST+ + +T SSS E ++ + + S E++ K E+LVL +
Sbjct: 1144 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1199
Query: 1644 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1703
H C S E + +++ D + PE+ I + + I ++L + S+
Sbjct: 1200 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1254
Query: 1704 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1763
E + + + EEN D++ +NQ+ +++++ + +SK+ LL K +
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1309
Query: 1764 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1790
S G + T+ + ++ +RKVS
Sbjct: 1310 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1337
Score = 32.3 bits (72), Expect = 4.9
Identities = 80/399 (20%), Positives = 143/399 (35%), Gaps = 52/399 (13%)
Query: 28 RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
R +K+ + S + E S+ +K+ K+++S K+K RN R S TS
Sbjct: 1106 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1165
Query: 88 NWGERLISSYRTYSEKEGPEKK-----------------KTKKEAGNKKSTPVSI----L 126
+ + + E E+K ++ + KS PV++
Sbjct: 1166 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1225
Query: 127 FGYPLSERKQMALLMQMTA-----RDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKR 181
P + + LL ++ A D S D P + T Q + K++VN
Sbjct: 1226 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1285
Query: 182 NERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI--A 239
++ R + + K +S G + K T E V + K+ +
Sbjct: 1286 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK----TKPKEHKEVKGRNRRKVSSEDS 1341
Query: 240 AGADVNTQGLDDD-TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL 298
+D G+ ++ + D R K L ++ K R + V E E
Sbjct: 1342 EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK-RRRIKVQEDSSSEN 1400
Query: 299 LLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET-----EKDSLICESKQILPSKTP 353
E +++E + EE + DEN DS++ +K I + ++ +T
Sbjct: 1401 KSNSE---EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL---RTE 1454
Query: 354 LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
+AL E +EE K I +R R++ R+ E E
Sbjct: 1455 TQNALKE-------EEERRKRIAEREREREKLREVIEIE 1486
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 99.4 bits (246), Expect = 3e-20
Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)
Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 335
NP +N E V E ++L + ++++ + D S D+ + + S E +D +
Sbjct: 671 NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 729
Query: 336 EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 395
+ D ++ K++ S + D D EI+ + L+ + K+++ + ++
Sbjct: 730 DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 781
Query: 396 THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 452
+ + F K KS K + + +ESS+ ++ K+I + + T+
Sbjct: 782 KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 839
Query: 453 DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 503
+ K++ S + H +KG + KN Q + ++ E KQE+E E T +
Sbjct: 840 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 899
Query: 504 TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 548
T+ D K ++ +G + S + TSL + H+ T K
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 959
Query: 549 GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 591
GLS+ LK++ + K G+ E D + Y+++ +E L
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 592 PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
PE + KS K ++K+ +KD ++ EKS K D S
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079
Query: 633 FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 675
++ + + K K L K K ++ +K K IE E+
Sbjct: 1080 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1139
Query: 676 YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 729
+K + KE+Q SD E N + + T KK K +
Sbjct: 1140 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1188
Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 788
++ K+ ++ + E D E S E+KIK + E N+ + F S
Sbjct: 1189 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1245
Query: 789 GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 824
G A+ +S+ + + + + D + + + K E K++ K
Sbjct: 1246 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1305
Query: 825 RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
+++ D E + E + KK ++ H+ + KL +S+ ++K K H
Sbjct: 1306 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365
Query: 879 EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
K K + + +++ E+ E D + + + K+ L E++ + +KK
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1425
Query: 936 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
++ E S SE N E++ E ++E+ ++E +EE++ D +K+ +
Sbjct: 1426 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1475
Query: 996 KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
+++ KD+ L+T ++++ R ER++ ++K L+ E + P
Sbjct: 1476 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1529
Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1092
P + E + L+Q ++ LK +++
Sbjct: 1530 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1566
Score = 55.8 bits (133), Expect = 4e-07
Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)
Query: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
++K KL + + S+ K + + + E K K+F+ + D+K+ +
Sbjct: 353 IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 411
Query: 780 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 839
D +SEF ++ E++ H K ID + + K K EK +++KDI K E K
Sbjct: 412 DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 463
Query: 840 TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 896
K+ +H H+ +E+ + + S + K+ D+ E + + + ++
Sbjct: 464 LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 522
Query: 897 T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 942
+ ++ E + E +D + D ++ + S + ++ K N+ S+
Sbjct: 523 SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 582
Query: 943 ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 981
Y K + + + D +E +DK+ ++++H+ E
Sbjct: 583 TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642
Query: 982 KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1041
+ S +++ E L + K PL+ P + D + E K K K+ +
Sbjct: 643 EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 695
Query: 1042 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1092
K K S D PKP P SK + ++ +D+++ + S S D +I
Sbjct: 696 RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 755
Query: 1093 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1144
+ H HK K +K + + ++ D +K K + SK K T+S+SS
Sbjct: 756 EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 815
Query: 1145 EVTDAYTKE 1153
KE
Sbjct: 816 NYDSELEKE 824
Score = 39.3 bits (90), Expect = 0.040
Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)
Query: 744 ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 801
E+ ++ + KIK +SEKS + E + ++ + ++ + ++ S +
Sbjct: 288 EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 347
Query: 802 VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 856
V KE+ I+K +K I+ + + ++ + E + K +++K KS +K
Sbjct: 348 VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 405
Query: 857 KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 907
L L E ++ + + D + K HK + K + A++K D KS K+
Sbjct: 406 HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 464
Query: 908 DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 965
RK D E + E + ++K+SD E + E N +D ++D S
Sbjct: 465 SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 523
Query: 966 DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 1004
E I N+ + +Q +E +SS V N + + +K KT
Sbjct: 524 VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 583
Query: 1005 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1037
+ P+K D +E +DKD + + ++H +
Sbjct: 584 KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642
Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1096
+++ LL+ P+ K++P RP E V + + E + + L + K
Sbjct: 643 EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 699
Query: 1097 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1143
K + K K+ E + +N + E+ KE ++ + + S + ++ +
Sbjct: 700 KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 759
Query: 1144 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
+ T K + KD R + DTK + KSS +S S N
Sbjct: 760 NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 818
Query: 1197 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1255
L SM + ++ T R P D D + S+ ++ S
Sbjct: 819 SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 872
Query: 1256 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1303
ERE S A+ + +RL S+S + V + + +
Sbjct: 873 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932
Query: 1304 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1363
++EVR+ + E +K +T + + Q L S++ E+ L
Sbjct: 933 SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 971
Query: 1364 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1421
S TS SK + ++ +PS + + + +E
Sbjct: 972 --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 1011
Query: 1422 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1473
D E L R+ IC + P +++ K K+ D S ++ EL
Sbjct: 1012 SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1068
Query: 1474 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1526
G+SC ++D S + ++ C +S + S + Y + +E G
Sbjct: 1069 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1127
Query: 1527 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1586
++ I + S ++T+ + +DA + ++ + + +KA V+
Sbjct: 1128 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1181
Query: 1587 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1643
EK N ST+ + +T SSS E ++ + + S E++ K E+LVL +
Sbjct: 1182 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1237
Query: 1644 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1703
H C S E + +++ D + PE+ I + + I ++L + S+
Sbjct: 1238 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1292
Query: 1704 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1763
E + + + EEN D++ +NQ+ +++++ + +SK+ LL K +
Sbjct: 1293 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1347
Query: 1764 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1790
S G + T+ + ++ +RKVS
Sbjct: 1348 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1375
Score = 32.3 bits (72), Expect = 4.9
Identities = 80/399 (20%), Positives = 143/399 (35%), Gaps = 52/399 (13%)
Query: 28 RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
R +K+ + S + E S+ +K+ K+++S K+K RN R S TS
Sbjct: 1144 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1203
Query: 88 NWGERLISSYRTYSEKEGPEKK-----------------KTKKEAGNKKSTPVSI----L 126
+ + + E E+K ++ + KS PV++
Sbjct: 1204 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1263
Query: 127 FGYPLSERKQMALLMQMTA-----RDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKR 181
P + + LL ++ A D S D P + T Q + K++VN
Sbjct: 1264 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1323
Query: 182 NERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI--A 239
++ R + + K +S G + K T E V + K+ +
Sbjct: 1324 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK----TKPKEHKEVKGRNRRKVSSEDS 1379
Query: 240 AGADVNTQGLDDD-TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL 298
+D G+ ++ + D R K L ++ K R + V E E
Sbjct: 1380 EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK-RRRIKVQEDSSSEN 1438
Query: 299 LLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET-----EKDSLICESKQILPSKTP 353
E +++E + EE + DEN DS++ +K I + ++ +T
Sbjct: 1439 KSNSE---EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL---RTE 1492
Query: 354 LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
+AL E +EE K I +R R++ R+ E E
Sbjct: 1493 TQNALKE-------EEERRKRIAEREREREKLREVIEIE 1524
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 98.6 bits (244), Expect = 6e-20
Identities = 176/857 (20%), Positives = 343/857 (40%), Gaps = 173/857 (20%)
Query: 424 SSTESSD---EEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEH-----KQKGKVKRK 475
S TE++ EEA + S+S SVI + + D Q K +S +H K+ K++ K
Sbjct: 1122 SGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKD---ISKDHIALTLKRLQKIRDK 1178
Query: 476 LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLD--CSEKTREEGNFRKSFSPKDDTS- 532
+++ + + K +K+GKE I T ++ ++K + +G S + T+
Sbjct: 1179 -RDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAG 1237
Query: 533 -----------LHLFHISTGKSPKHS----------------------------CGLSEK 553
L IS G K S C L +K
Sbjct: 1238 DGSSWRDDLCRLMALRIS-GSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKK 1296
Query: 554 QSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 613
+S L ++ + P + +Q +R D + + + + +HKE ++
Sbjct: 1297 ESKVLLEDLDWDVVPPEKKPIFIQEGAIRED------MIQGVTQEVIRHKEVMPREE--- 1347
Query: 614 LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDK-----EGKTLKKHKLKHKEREKEKHKKE 668
E++ K +D E + LKK K G ++ KE +K K
Sbjct: 1348 ----EQAQKKARD---MLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSP 1400
Query: 669 IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL------FLNMEHESLTLEK 722
+G K K + K RE KE S+E E++ + E + + +E+
Sbjct: 1401 KQGRKAVQKERKVGK-------IKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
Query: 723 KSKLEKNIKDDKSTKEKHVSKERNFK-----------EERDKIKKESEKSFREEKI---- 767
+ K K+ H +++K +E +K+ + EK EE++
Sbjct: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513
Query: 768 KDLKEER-----ENIPTDKDSE--FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKES-- 818
K LK E EN+ + K E + +EE + EKE + ++++HI+E
Sbjct: 1514 KKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHK 1573
Query: 819 -------KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEH--------KSEKDKLDLSEC 863
+ + EK+ +E+ + + E K ++E+++ E K +D ++++
Sbjct: 1574 WARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQA 1633
Query: 864 VDKIKEKDKLYSHHTEKCHKEGEK--SKNTAAIKKTDDREKSREKMDRKHDK-------- 913
K +K++ + EK +E EK K KK + + EK+ +K K
Sbjct: 1634 EGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNIL 1693
Query: 914 -----EKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
E P++E++L +++ E + + D E S E+ N+E+ + +++K+K ++E
Sbjct: 1694 AQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE 1753
Query: 969 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTK--DEPLKTPDGKEK-DKKDKDID 1025
+ + EE+ K E+ L ++EK K K P+ +E+ +K + +
Sbjct: 1754 EALAWQREKLSEEE-------TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI 1806
Query: 1026 RYKERDKHKDKIQINSLLKL----------KSEADKPKPKSSPASKDTRPKEKRLVNDDL 1075
K + K + INS+ +L K+ A + K + K + KE L N +
Sbjct: 1807 EKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKER 1866
Query: 1076 MQTSFERMLSLKD---------LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
+ S ++++ +K+ ++E+ + KE + K+KE+L ++++D
Sbjct: 1867 LTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSLAK 1925
Query: 1127 KHTPTESKNKELTRSKS 1143
K + +L K+
Sbjct: 1926 KQEKLAQEKMKLALEKA 1942
Score = 84.7 bits (208), Expect = 8e-16
Identities = 149/756 (19%), Positives = 305/756 (40%), Gaps = 104/756 (13%)
Query: 318 EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD-DEEINKMID 376
E +++ V+E E D + K++ L ++E +K+++ ++E K+++
Sbjct: 1688 EVKNILAQKVEELPQREQNLD---WQEKELAQELEELEWDMEELSWKEEELNQEEGKLVE 1744
Query: 377 DRHILRKEQRK---ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEA 433
++ L +E+ + E +E+ A++E+ + K + K E
Sbjct: 1745 EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQ 1804
Query: 434 LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKV----KRKLKNQNKN--KENQE 487
L KK+ + Q ++ ++ S E K K+ K+ L + KN +E ++
Sbjct: 1805 LIEKKMKLA------------QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
Query: 488 LKQEKEGK--ENTRITN-----LTVNTGLDCSEK---------TREEGNFRKSFSPKDDT 531
L Q KE R+T+ + V L K T+E+ K +T
Sbjct: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912
Query: 532 SLHLFHISTGKSPKHSCGLSEKQSTPLKQ------EHTKTCLSPGSSEMSLQPDLVRYDN 585
L + + K EK L++ + + L E +L ++ R
Sbjct: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAE 1972
Query: 586 TESEFLPESSSVKSCKHKEKSKHQKDFHLE---FGEKSNAKIK---DEDHSPTFENSDCT 639
+ + ++ + E S+ +K +E F K + + K ED E S+
Sbjct: 1973 EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIA 2032
Query: 640 LKKMD--KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK 697
K++ + + + + K + ++ KK KE K K LQ+ +R+ +
Sbjct: 2033 KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ 2092
Query: 698 ENFFKSDETEDLF-----LNMEHESLTLEKKSKLEKN---IKDDKSTKEKH--------- 740
E + LF L++E L +++ EK KD+K K
Sbjct: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRR 2152
Query: 741 -VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT--------------DKDSEF 785
++KE EE K+ ++ + +++ + EE E IP DK E
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEK 2212
Query: 786 TSLGMSAIE---------ESIGLHLVEKEIDI---EKQEKHIKESKEKPEKRSQIKE-KD 832
S + +E ES+ L +EK+ + E++E+ +E +E+ E R + +E K+
Sbjct: 2213 FSSQVDEVESEEHFSEEMESL-LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKE 2271
Query: 833 IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
E+ E K EKE++ K + K EK K ++ E + +EK+++ S + + E+ + +
Sbjct: 2272 EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESC 2331
Query: 893 AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNK 952
++++ DREK K +++ + E+ R +E+ L + + K+
Sbjct: 2332 SLEEEVDREKEILKKEKQFKLQ--EQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSP 2389
Query: 953 EKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVD 988
K + + + ++K + + + E+KK+++V+
Sbjct: 2390 LK-KLMSTALEMKEKTPVPVPEKQISWEDKKATVVE 2424
Score = 83.6 bits (205), Expect = 2e-15
Identities = 179/891 (20%), Positives = 354/891 (39%), Gaps = 138/891 (15%)
Query: 382 RKEQRKENEPEAEKTH-----LFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQN 436
++E K E EK H L ++E K K ++ K S++S +++
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541
Query: 437 KKISTSCSVIPETSNSDMQ-TKKEYVVSGEHKQKGKVKRKLKNQNKN-KENQELKQEKE- 493
++++ V E + Q T+++ + EHK +++ + + K +E ++L QE+E
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601
Query: 494 --------GKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK 545
+E ++ V D E + EG F + K++T
Sbjct: 1602 LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ----KEETLA------------ 1645
Query: 546 HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH--- 602
++ L QE K L + E + + + K+
Sbjct: 1646 -------QRGEKLSQEAEKLA----QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA 1694
Query: 603 -KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKERE 661
K + Q++ +L++ EK A+ +E E S + +EGK +++ K +E E
Sbjct: 1695 QKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEE 1754
Query: 662 KEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLE 721
++E E+E ++ +Q ++E ++ K E E+ L + E L +E
Sbjct: 1755 ALAWQREKLSEEETKLAQEEELLIQ-----EKEKLAQHKEKMPEEEER-LGRKREQL-IE 1807
Query: 722 KKSKLEK------NIKDDKSTKEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEER 774
KK KL + N ++ + + + +++N +E+ + +E EK + R+E + KE
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
Query: 775 ENIPTDKDSEFTSLGM-----SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
+ LGM + +EE + EKE I+K+EK + EK+
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKL---TQEKETVIKKKEK-----LAETEKKLVQV 1919
Query: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
E + K + K +++ K+ E + K L +D KE+ L ++ +
Sbjct: 1920 EDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979
Query: 890 NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYS 944
+ K + E SR++ + ++E E++ L E H ME+ E++
Sbjct: 1980 GKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT 2039
Query: 945 KSEK----GKNK--EKDRELDKKEKSRDKESINITN-----SKHIQEEKKSSIVDGNKAQ 993
+ ++ G+ K + R+L KK +S KE + K ++E+K + + +
Sbjct: 2040 RGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099
Query: 994 HEKPLSLKEKTKDEPLKTPDGKEKD---------KKDKDIDRYKERDKHKDKIQINSLLK 1044
++ L +KE+ D KE D K +K + R + + +K + IN K
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159
Query: 1045 LKSEADKPKPKSSP-----------------------------ASKDTRPKEKRLVNDDL 1075
+ E K K S A + +PKEK D
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219
Query: 1076 MQTS---FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1132
+++ E M SL D E+E+ E+ +++E+E R E +++++E+ + E
Sbjct: 2220 VESEEHFSEEMESLLD-ELEKQESLSSEEEEEREEEEERE----EEEVREEEEERKEEEE 2274
Query: 1133 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSD 1183
+ K++ K E KEK+ ++ + + +M+ ++ +SD
Sbjct: 2275 GEEKQV--EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD 2323
Score = 83.6 bits (205), Expect = 2e-15
Identities = 179/924 (19%), Positives = 377/924 (40%), Gaps = 114/924 (12%)
Query: 294 EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 353
+E E L + LS ++E + ++ + V EN+ S K+ + +++ T
Sbjct: 1491 QEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEV----TL 1546
Query: 354 LPSALDEYEFKDDDDEEINKMIDDRH----ILRKEQRKENEPEAEKTHLFAKQEK-AFYP 408
E E K+ E + I + H I RK R E + E+ L ++EK A
Sbjct: 1547 EEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE 1606
Query: 409 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
+ +++K ++ T+ E A K + + + +S E ++
Sbjct: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEK---------LSQEAEK 1657
Query: 469 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 528
+ ++KL + + +E K K+G + + N+ + ++ + K + +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 529 -DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNT- 586
++ + +S + + ++ L +E K L+ ++ Q + + + T
Sbjct: 1718 LEELEWDMEELSWKEEELN------QEEGKLVEEKKK--LAEEEEALAWQREKLSEEETK 1769
Query: 587 ---ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 643
E E L + K +HKEK +++ G K I E + + + M
Sbjct: 1770 LAQEEELLIQEKE-KLAQHKEKMPEEEE---RLGRKREQLI--EKKMKLAQKRERWINSM 1823
Query: 644 DKEGKTLKKHKL-KHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE---FWKEN 699
++ L K+K+ ++++ + KK + EKEK + + ++ +++E K+
Sbjct: 1824 EE----LTKNKMILYQKKNLAQEKKNLAQEKEKLAQR------KENLLYNKERLTHSKKQ 1873
Query: 700 FFKSDETEDLF---LNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 756
+ +F L E LT EK++ ++K K + T++K V E + ++++K+ +
Sbjct: 1874 LVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE-TEKKLVQVEDSLAKKQEKLAQ 1932
Query: 757 ESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 815
E K + + ++ K R + K+ + +L M + E + LVE + + K E
Sbjct: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEE-KMRLVEGKETLSKGET-- 1989
Query: 816 KESKEKPEKRSQIKEKDIEK--MERKTFEKEKKIKHEHK------SE--KDKLDLSECVD 865
PE Q K +E+ ERK +EK + HE + SE K KL+ +
Sbjct: 1990 ------PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR 2043
Query: 866 KIKEKDKLYSHHTEKCHKEGEK-SKNTAAIKKT---------DDREKSREKMDR-KHDKE 914
+ + + + K K+ E SK A + K D+R+ ++E++ K +
Sbjct: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103
Query: 915 KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITN 974
KER L+ + K +++ + SE +K EK K K R+L K + + +T
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK-KLARKQRKLANKMRRMINKEEKMTE 2162
Query: 975 SKHIQEEKKSSIV-----DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1029
+ K S ++ +G + E LK + + K K+K +D +
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222
Query: 1030 RDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDL 1089
+ ++++ L E +K + SS ++ +E+R ++
Sbjct: 2223 EEHFSEEME-----SLLDELEKQESLSSEEEEEREEEEER-----------------EEE 2260
Query: 1090 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1149
E+ + ++ KE+ + +EK+ + + K K+K+K + E +E S E T++
Sbjct: 2261 EVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Query: 1150 YTKEKQPKDAVSNRSQSVDTKNVM 1173
+ E++ +++ S + K ++
Sbjct: 2321 LSDEEEEEESCSLEEEVDREKEIL 2344
Score = 67.4 bits (163), Expect = 1e-10
Identities = 157/730 (21%), Positives = 296/730 (40%), Gaps = 152/730 (20%)
Query: 571 SSEMSLQPDLVRYDNTESEFLP---ESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 627
S +MS +P L+ D + +E P E +SV S S + ++ EK +K
Sbjct: 1108 SKQMSTEPGLLE-DESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISK---- 1162
Query: 628 DHSPTFENSDCTLKKM----DKEGKTLKKHKLKHKEREKEKHKKEIEGE-----KEKYKT 678
DH TLK++ DK K KLK K ++K K K I E E+ T
Sbjct: 1163 DHIAL------TLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVT 1216
Query: 679 KD--------SAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI 730
K S +RS D W+++ + + L + + + E
Sbjct: 1217 KKVKIQGRGASGISGRRSTAGDGSSWRDDLCRL-----MALRISGSQTKMSENLNAELVT 1271
Query: 731 KDDKSTKEKHVSKERNFKEERDKIKKES----------------------EKSFREEKIK 768
+ ++H S E F+E +KKES E + RE+ I+
Sbjct: 1272 FAQEMLVDRHPSWEL-FQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQ 1330
Query: 769 DLKEE----RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI--------- 815
+ +E +E +P +++ + +GL E ++ ++K +K I
Sbjct: 1331 GVTQEVIRHKEVMPREEEQ-----AQKKARDMLGLE--ETQVILKKGKKVIFLEPGNVTM 1383
Query: 816 -KESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDK------- 866
KE +K EK++ K K RK +KE+K+ K + + K++ D+SE V++
Sbjct: 1384 GKEISKKEEKKTFQKS---PKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440
Query: 867 -IKEKDKLYSHHTEKCHKE------------GEKSKNTAAIKKTDDRE--KSREKMDRKH 911
+K++ KL ++ GE K+ A K+ ++ + EK+ +
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500
Query: 912 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSR---DKE 968
+K PE+E + + +K E+ + +N SKS++ + K+++ ++E SR +KE
Sbjct: 1501 EKLSPEEE--MLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558
Query: 969 SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGK--EKDKK--- 1020
+HIQEE K + + +A+ EK + +E+ ++E L + + ++++K
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618
Query: 1021 --------DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK---DTRPKEKR 1069
D+++ + + + K++ KL EA+K K +K +E++
Sbjct: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
Query: 1070 LVNDDLMQTSFERMLSLKDLEIEQ------WHKKH-----------KEKIKQKEKERLRN 1112
L + +L+ K E+ Q W +K E++ KE+E +
Sbjct: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
Query: 1113 RNCL---ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEK--QPKDAVSNRSQSV 1167
L + K+ ++E+ E ++E T+ E KEK Q K+ + + +
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
Query: 1168 DTKNVMTLGK 1177
K + K
Sbjct: 1799 GRKREQLIEK 1808
Score = 65.9 bits (159), Expect = 4e-10
Identities = 111/508 (21%), Positives = 222/508 (43%), Gaps = 58/508 (11%)
Query: 602 HKEKSKHQKDFHLEFGEKSNA--KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
+KE+ H K ++ K KI + + + +KK +K +T KK L E
Sbjct: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK--LVQVE 1920
Query: 660 REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
K ++++ EK K + + + ++ + + + KE + E + L E +
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRL---AEEKMRL 1977
Query: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
+E K L K + S + K E+ E K+ E + E++I L E I
Sbjct: 1978 VEGKETLSKGETPETSRQRKMTQVEQELFER--KLSLEEKILLHEDRI--LAMEESEIAK 2033
Query: 780 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE------------KPEKRSQ 827
K EFT ++ L +++ I+K+E KE + + E++
Sbjct: 2034 GK-LEFTRGQRIFVQGQRKLAKASRKL-IKKRESLSKEPAKLNKILKALQKLTRDERKLT 2091
Query: 828 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE- 886
+E + KM+R F KE+++ E+ KLD+ E D +++ +L + K+ +
Sbjct: 2092 QEEIKMTKMKRALFVKERRLS----IEQSKLDIKEW-DFSEKRSELTKDEKKLARKQRKL 2146
Query: 887 KSKNTAAIKKTDDREKSREKMDRKH------DKEK---------PEKERHLAESKEKHL- 930
+K I K + + K+ RKH D+E+ P +R + KE
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206
Query: 931 ---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 987
EK + Q D E SE+ ++E + LD+ EK +ES++ + +EE++
Sbjct: 2207 DKPKEKFSSQVDEVE---SEEHFSEEMESLLDELEK---QESLSSEEEEEREEEEEREEE 2260
Query: 988 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK-HKDKIQINSLLKLK 1046
+ + + E+ +E + + K + K+K KK+K + +E+++ ++K +I S + +
Sbjct: 2261 EVREEEEERK-EEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETE 2319
Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDD 1074
S +D+ + + S + ++ +EK ++ +
Sbjct: 2320 SLSDEEEEEESCSLEEEVDREKEILKKE 2347
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 98.6 bits (244), Expect = 6e-20
Identities = 97/451 (21%), Positives = 212/451 (47%), Gaps = 43/451 (9%)
Query: 603 KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
KEK+ K Q+ L EKS ++ ++ E + L + D GK L+
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 654 KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
KL+ + E E + + ++EK ++ ++ +E + ++ E +E K E E+
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400
Query: 713 MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 772
E E+K + ++ + +K +EK +E E+ +KI++ EK +EKI++ +E
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 458
Query: 773 ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
+R E I + + M EE I E+E I +QE+ + +EK ++ +I+
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEEKMWRQEEKIHEQEKIR 514
Query: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
E++ + + + + +E+KI+ + + + K + E +KI+++++ EK H + EK +
Sbjct: 515 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 890 NTAA---------------IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK--HLME 932
I++ +++ + +E+M ++ +++ E+E + E +EK E
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634
Query: 933 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 992
K +Q + + + + +EK RE ++ + ++++ QEEK + +
Sbjct: 635 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE-------QEEKMCEQEEKMQE 687
Query: 993 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1023
Q EK +EK ++ ++ +EK ++ ++
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 96.7 bits (239), Expect = 2e-19
Identities = 111/515 (21%), Positives = 240/515 (46%), Gaps = 48/515 (9%)
Query: 661 EKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
+K+K + IE E K +D+ EL R+ D E ++N ++ + L
Sbjct: 248 QKKKADRYIE---ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ----------LV 294
Query: 720 LEKKSKLEKNIKDDKSTKE--KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777
+KS+++ N+K+ K E K + ++ + E D + KE + + + + + E N
Sbjct: 295 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 778 PTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI---KEKDIE 834
+ E I+E + E+E I +QE+ I+E +EK ++ ++ KE+ +
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEE-KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413
Query: 835 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 894
+ E +EKE+K++ + + +K E + +++EK H EK ++ EK + I
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEK---EEKIRELEEK----MHEQEKIREQEEKRQEEEKI 466
Query: 895 KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
++ + R++ KM R+ +K + E+E + E +EK M ++ ++ E + E+ K +E+
Sbjct: 467 REQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEK--MWRQEEKIHEQEKIREEE-KRQEQ 522
Query: 955 DRELDKKEKSRDKESINITNSK-HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 1013
+ ++EK R++E I K H QEEK + Q EK +EK D+ K +
Sbjct: 523 EEMWRQEEKIREQEEIWRQKEKIHEQEEKI-------RKQEEKMWRQEEKMHDQEEKIRE 575
Query: 1014 GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVND 1073
+EK + ++ R +E + + +I ++ E ++ K +EK +
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE---------KMGEQEEKMCEQE 626
Query: 1074 DLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTES 1133
+ MQ E+M ++ EQ K +++ K +E+E + ++ ++++ +
Sbjct: 627 EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686
Query: 1134 KNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1168
+ +E R + ++ + + +Q ++ + + ++
Sbjct: 687 EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 91.7 bits (226), Expect = 7e-18
Identities = 76/358 (21%), Positives = 182/358 (50%), Gaps = 25/358 (6%)
Query: 641 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 700
K ++E K ++ + ++ EK + ++E+ EKE+ + ++ + R+ +E
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ--EEMM 433
Query: 701 FKSDETEDLFLNMEHESLTL---EKKSKLEKNIKDDKSTKEKHVS---KERNFKEERDKI 754
++ +E HE + E+K + E+ I++ + +E+ +E +E+ +KI
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493
Query: 755 KKESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEK 813
+++ EK +R EEKI + ++ RE + E M EE I ++ +I +Q++
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKI-----REQEEIWRQKE 543
Query: 814 HIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKE 869
I E +EK K+ + + EKM E K E+E+K+ + E K + + + E +KI+E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 870 KDKLYSHHTEKCHKEGEK-SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
++++ EK ++ EK + +++ +++ + +E+ R+ +K+ E+E + E +E+
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-QEE 662
Query: 929 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
+ E++ K + E ++ K +E++ ++ ++E+ ++ + + + +E + +
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 58.9 bits (141), Expect = 5e-08
Identities = 87/492 (17%), Positives = 209/492 (42%), Gaps = 61/492 (12%)
Query: 378 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 434
R+ + E+ KE + ++ + EK+ + K K+K R +L ++ + L
Sbjct: 272 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 331
Query: 435 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 489
+ S S + + +++ Q ++E + E K + ++ + + K +E +E
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 490 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 549
+E+E K + + + EK R + + K++ + K K
Sbjct: 392 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK---- 439
Query: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
+ E + +QE + E ++ R + E++ + ++ + K + + +
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEE 498
Query: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK--EKHKK 667
K + E KI++E+ E +K+ ++ + ++ + H++ EK ++ +K
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 668 EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLE 727
E++ + ++ +E + V E +E K E E+ E E +T E++ K+
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI--REQEEMTQEQEEKMG 616
Query: 728 KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTS 787
+ +EK +E +E+ +K++++ EK +E K ++E+ E I
Sbjct: 617 EQ-------EEKMCEQEEKMQEQEEKMRRQEEKIREQE--KKIREQEEKIR--------- 658
Query: 788 LGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PEKRSQIKEKDIEKMERKTFEKE 844
E+E +++QE+ + E +EK E++ Q +E+ + + E K +E+E
Sbjct: 659 ---------------EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703
Query: 845 KKIKHEHKSEKD 856
+++ + + ++
Sbjct: 704 VRLRQQEEKMQE 715
Score = 42.7 bits (99), Expect = 0.004
Identities = 59/317 (18%), Positives = 134/317 (42%), Gaps = 23/317 (7%)
Query: 842 EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 896
E I H S K +L + + + + K + E+ KE E +NT ++
Sbjct: 220 EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 279
Query: 897 TDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYSKSEKGKN 951
++ ++ + + EK E + ++ E K K L+ ++ Q++ K + +
Sbjct: 280 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 339
Query: 952 KEKDRELDKKEK----SRDKESINITNSKHIQE--EKKSSIVDGNKAQHEKPLSLKEKTK 1005
+ ++++ E ++ +E + IQE EK + + Q EK +EK +
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 399
Query: 1006 DEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRP 1065
+ + +EK ++ +++ KE K + Q + + + + + + K K
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 456
Query: 1066 KEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEK 1125
+EKR + + + + K E+ ++ +EKI+++E++ R E KI ++EK
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ----EEKIHEQEK 512
Query: 1126 TKHTPTESKNKELTRSK 1142
+ + +E+ R +
Sbjct: 513 IREEEKRQEQEEMWRQE 529
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 98.6 bits (244), Expect = 6e-20
Identities = 230/1127 (20%), Positives = 473/1127 (41%), Gaps = 147/1127 (13%)
Query: 279 QANKHGERPVDVAET-----EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
Q ++G VDV + + E+ K E P SD + D +++
Sbjct: 233 QRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL----------- 281
Query: 334 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 393
ET + + + + K + S ++ + E + + +D+R L++ ++ ++ A
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER--LQELEKIKDLHMA 339
Query: 394 EKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKK--ISTSCSVIPE--T 449
EKT L + A K+ + ++ ++ + T+ E L+ K+ I+ S I + T
Sbjct: 340 EKTKLITQLRDA---KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 450 SNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKE-NQELKQEKEGKENTRITNLTVNTG 508
+++ +KE E ++++ L K +E ++LK E + + T
Sbjct: 397 QGEELREQKE---KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT---------- 443
Query: 509 LDCSEKTREEG--NFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTC 566
EKT EE + ++ S + + S+ + L EK+ +QE TK
Sbjct: 444 ---IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500
Query: 567 LSPGSSEMSLQPDL-VRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEK-----S 620
+ E Q + V + ++SE+L K + KE+ + LE +K S
Sbjct: 501 QT---REREFQEQMKVALEKSQSEYL------KISQEKEQQESLALEELELQKKAILTES 551
Query: 621 NAKIKD-----EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK 675
K++D E + + +L+K +E K K H E EK KH KEI EK
Sbjct: 552 ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611
Query: 676 YKTK-DSAKELQRSVEFDR-EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD- 732
+KT+ +S K Q ++ ++ + K+ + E E E+L +K+ + +I++
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 733 DKSTKEKHVSKE---RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
++ T EK K+ + E ++ K K EE++ LK++ + + + +++
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHK--LEEELSVLKDQTDKMKQELEAKMDE-Q 728
Query: 790 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
+ ++ + + E E+ I++ EK +K+ + E + ++K +++ + E IK
Sbjct: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 850 ---EHKSEKDKLDLSECVDK-IKEKDKLYSHHTEKCHKE--GEKSKNTAAIKKTDDREKS 903
E + KLD+ + E+ K Y + ++ +++ K+ + E
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 904 REKMDRKHDKEKPEKERHLAE-SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE---LD 959
++ + + D K + + + + K+ ME+K K SK E G NKE+++ L
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG-NKEQEQTKQILV 907
Query: 960 KKE------KSRDKESINITNSKHIQEEKKSSIVDGN-----KAQHEKPLSLKEKTKD-- 1006
+KE + K+ I I K +E I++ K Q +K +K+K K+
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 1007 EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1066
E LK ++ K K+++ K+K Q N+ + ++A+ + + +T K
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEK-QFNAKMLEMAQANSAGISDAVSRLETNQK 1026
Query: 1067 E---------KRLVNDDLMQTSFERMLSLKDLEIEQWHK---KHKE----KIKQK----- 1105
E +R +ND + + +E+ L+ + E+++ H+ + KE ++KQK
Sbjct: 1027 EQIESLTEVHRRELNDVI--SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG 1084
Query: 1106 -EKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRS 1164
EKE + N+ LK +E K T ++ +E + KS+ V E + K +
Sbjct: 1085 CEKEEM-NKEITWLK---EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL---- 1136
Query: 1165 QSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPR 1224
+ ++ +L +++F+ + + +E +K +S + + + S ++
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196
Query: 1225 PPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTS 1284
+E D LE + + + K+ AL E + + L ++ +R+S
Sbjct: 1197 KSLE---DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 1285 HLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESN 1331
R++ V++ LI + C+ + E Q + ++EE N
Sbjct: 1254 QHRTTKVKEALLI----------KTCT----VSELEAQLRQLTEEQN 1286
Score = 97.4 bits (241), Expect = 1e-19
Identities = 184/933 (19%), Positives = 380/933 (40%), Gaps = 118/933 (12%)
Query: 277 PFQANKHGERPVDV-AETEELELLLKREVPLSDDDESYTDSEEAQ-------SVNPSSVD 328
P QA+ + P + + T L P + ++ + +++ Q S+ S +
Sbjct: 22 PAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIK 81
Query: 329 ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE 388
E++ + K+SL+ S + ++ L S+ ++ D D E ++ + L KEQ +
Sbjct: 82 ESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQ 141
Query: 389 NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV--- 445
E++ + + + +++ +++ ++ ++S D+ + ++ +
Sbjct: 142 RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQ 201
Query: 446 ----IPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRIT 501
+ E ++ ++ K +Y +S Q +K++L+N N + LK + + +
Sbjct: 202 AKKHLQEEFDASLEEKDQY-ISVLQTQVSLLKQRLRNGPMNVD--VLKPLPQLEPQAEVF 258
Query: 502 NLTVNTGLDCSEKTREEGNFRKSFSP-----KDDTSLHLFHISTGKSPKHSCGLSEKQST 556
N D E E+G K+ K +L T +S K C L +
Sbjct: 259 TKEENPESD-GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 557 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE--SEFLPESSSVKSCKHKE-----KSKHQ 609
L+++ L E+ DL + T+ ++ + ++ + + ++K Q
Sbjct: 318 ALQEQ-----LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
LE E+ A+++ +K+M +G+ L++ K K + E+ +K +
Sbjct: 373 MHETLEMKEEEIAQLRSR------------IKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME-----HESLTLEKKS 724
T +E +R ++ + + + K+ E E + L E E + + KKS
Sbjct: 421 -------STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473
Query: 725 ------KLEKNIKDDKSTKEKHVSK-----ERNFKEERDKIKKESEKSFREEKIKDLKEE 773
KL+K + + + KE+ ++K ER F+E+ ++S+ + KI KE+
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQ 531
Query: 774 RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI--KEK 831
+E++ A+EE L L +K I E + K +E R++I E
Sbjct: 532 QESL--------------ALEE---LELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 832 DIEK--MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
+EK E K K+ + E + K +++ V+K K + + H + E
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE---KL 631
Query: 890 NTAAIKKTDDREKSREKMDRKHDKEKPEKE----RHLAESKEKHLMEKKNKQSD----NS 941
+ + EK REK +++ + +KE H+ E EK L + KQ++ +S
Sbjct: 632 QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
Query: 942 EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
E S+ K ++K + EL + DK + Q+ VD +HE +
Sbjct: 692 ELSEVLKARHK-LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRT 750
Query: 1002 EKTKDEPLKTPD--GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1059
EK + + + KE+DK K+ + E + K L + ++ D + S
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 1060 SKDTRPKEKRL--VNDDLMQTSFERMLSLKDLEIEQWHKK--------HKEKIKQKEKER 1109
+ T+ E++L + L+ ER+L K + + KK HK +++ ++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 1110 LRNRNCLELKIKDKEKTKHTPTESKNKELTRSK 1142
+ + +E K+K + + E NKE ++K
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Score = 83.2 bits (204), Expect = 2e-15
Identities = 170/851 (19%), Positives = 336/851 (39%), Gaps = 119/851 (13%)
Query: 370 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 429
+I ++ ++ L+KE + + +EK + +K S+ ++ +
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL------SENINAVTLMKEELKEK 1365
Query: 430 DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ---------- 479
E K T +V + NS ++KE +S KQ + K +L +Q
Sbjct: 1366 KVEISSLSKQLTDLNV--QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423
Query: 480 ----------------NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRK 523
NK E ++ Q + + + L + L E ++
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 524 SFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRY 583
D + F G+ +K K+ + +T L ++ + D +
Sbjct: 1484 LKEELDQQNKR-FDCLKGEME------DDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 584 DNTESEFLPES----SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD-EDHSPTFENSDC 638
E E L E + K +HKE + + F E GE+ + ++K+ E+ T EN
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQVY 1595
Query: 639 TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKE--------KYKTKDSAKELQRSV 689
++K +++ + K L+ L K +E+E E E E K K + +++ +
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655
Query: 690 EFDREFWKENFFKSDETEDLFLNM-----EHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 744
E +E + K E+ LN E E LE+K K ++ + + +
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715
Query: 745 RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV-- 802
+ E+ + + + EEKI L+ T+K+ +G EE++ H
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNL----TEKEKLLQRVGQEK-EETVSSHFEMR 1770
Query: 803 ----EKEIDIEKQEK----------HIKES-KEKPEKRSQIKEKDIEKMERKT-FEKEKK 846
E+ I +E E H++E +EK +K S I + +EK K + ++
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN 1830
Query: 847 IKHEHKSEKDKLDLSECV-----DKIKEKDKLYSHHTEKCHKEGE----KSKNTAAIKKT 897
+++ + L E KIKE D E E E K + A+++
Sbjct: 1831 LENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
Query: 898 DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD----NSEYSKSEKGKN-- 951
D R K E ++ +++ + HL + K ME ++ + +E K + GK
Sbjct: 1891 DGRNKPTELLEENTEEKS---KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV 1947
Query: 952 -KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK 1010
+KD + +KE ++ E + K +E++ I Q ++ L LK + + L
Sbjct: 1948 RLQKDLRMLRKEHQQELEILK----KEYDQEREEKI-----KQEQEDLELKHNSTLKQLM 1998
Query: 1011 TPDGKEKDKKDKDIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1069
+ +K+++++ KE +++ L + E ++ K + D + KR
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Query: 1070 LVNDDLMQTSFERMLS-LKDLE--IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
++++ E M + ++DL+ +E+ KK+++K++Q+E N +EL+ + +KT
Sbjct: 2059 Y--EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
Query: 1127 KHTPTESKNKE 1137
++SK KE
Sbjct: 2117 T-LISDSKLKE 2126
Score = 82.8 bits (203), Expect = 3e-15
Identities = 187/911 (20%), Positives = 376/911 (41%), Gaps = 131/911 (14%)
Query: 343 ESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQ 402
+ +++ + L + +E++ E+ NK ++D+ + E +K +E A + + K+
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL---EFKKLSEELAIQLDICCKK 1223
Query: 403 EKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVV 462
+A ++++ + + K + S I + + K+ ++
Sbjct: 1224 TEALL-----------------EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 463 SG--EHKQKGKVKRKLKNQNK-NKENQELKQEKEGKENTRITNLTVNTGLDCSEKT---R 516
+ + ++++ + QN N Q+ + E KEN +I ++ + +EK +
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN-QIKSMKADIESLVTEKEALQK 1325
Query: 517 EEGNFRKSFSPKDDTSLHLF-HISTG-----------KSPKHSCGLSEKQSTPLKQEHTK 564
E GN +++ S K+ L +S K K KQ T L + +
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ-LQ 1384
Query: 565 TCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS-----CKHKEKSKHQ-KDFHLEFGE 618
+S E ++ +YD + E L + + K K + Q D+ +F E
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 619 -KSNAKIKDEDHSPTFENSDCTLKKMDKEGK------TLKKHKLKHKEREKEKHKKEIEG 671
K A+ + H T + L+ KE L K +L + + + K E+E
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Query: 672 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
+K K + K+S E + K + E ED ++ +++ +E +++ KN
Sbjct: 1505 DKSKMEKKESNLETE---------LKSQTARIMELED---HITQKTIEIESLNEVLKNYN 1552
Query: 732 DDKSTKEKH-VSKERNFK---EERDKIKKESEKSF--REEKIKDLKEERENIPTDKDSEF 785
K + K V K ++F+ EE+D KE+E+ E ++ +K E E K+ E
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET--KKKELEH 1610
Query: 786 TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEK 845
+L + + EE L +E ++ E K + ++ +K + IK++ + +ME K E+ K
Sbjct: 1611 VNLSVKSKEEE--LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE-EQYK 1667
Query: 846 KIKHEHKSE-KDKLDLSEC-VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKS 903
K H SE KL E V ++EK K + +KN AA + ++ + S
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD-S 1726
Query: 904 REKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 963
+ + + ++++ +R+L E KEK L+++ ++ + + S E + L K E
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTE-KEK-LLQRVGQEKEETVSSHFE--MRCQYQERLIKLEH 1782
Query: 964 SRDKESINITNSKHIQEE-----KKSSIV-------DGNKAQHEKPLSLKEKTKDEPLKT 1011
+ K+ + + H+QEE KK S++ +G K + +L E D+ KT
Sbjct: 1783 AEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL-ENVFDDVQKT 1841
Query: 1012 PDGKE-----KDKKDKDIDRYKERDKHKDKIQINSL---------LKLKSEADKP----K 1053
KE ++K K++D R K ++++ L L+ +KP +
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 1054 PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLE--------------IEQWHKKHK 1099
+ SK + K L N + E L+ + E + K+H+
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 1100 EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
++++ +KE + R E KIK +++ S K+L R ++++ + +
Sbjct: 1962 QELEILKKEYDQER---EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 1160 VSNRSQSVDTK 1170
N++Q V+ +
Sbjct: 2019 TINKAQEVEAE 2029
Score = 68.2 bits (165), Expect = 8e-11
Identities = 137/717 (19%), Positives = 290/717 (40%), Gaps = 131/717 (18%)
Query: 308 DDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEY--EFKD 365
+DD+S + +E S+++ + S+T + I E + + KT +L+E +
Sbjct: 1503 EDDKSKMEKKE------SNLETELKSQTAR---IMELEDHITQKTIEIESLNEVLKNYNQ 1553
Query: 366 DDDEEINKMIDD-RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYS 424
D E +++ +H + K+N + + + + + + K+ K+K +
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 425 STESSDEE--ALQNKKISTSCSVIPETSN--------------SDMQTKKEYVVSGEHKQ 468
S +S +EE AL+++ S S + + E S M+ K+E G
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 469 KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDC------SEKTREEGNFR 522
++ KL Q + +E L+++ + E+++ L V E+ +G +
Sbjct: 1674 LSELNTKL--QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 523 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 582
K++ K + + EK + QE +T S Q L++
Sbjct: 1732 KTYEEKISVL------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 583 YDNTESEFLPESSSVKSCKHKEKSKHQKDF-----HLEF-GEKSNAKIKD------EDHS 630
++ E++ + S + + + + K++K H+E G K+N + K +D
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 631 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 690
T + + T + ++++ K L + R+KE H+ E+E KY+ + +++
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLV----RQKEVHRVEMEELTSKYEKLQALQQMDG--- 1892
Query: 691 FDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEE 750
++ TE L N E +S + + KL N++ + E ++ E
Sbjct: 1893 -----------RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA-----E 1936
Query: 751 RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 810
R+K K E ++ ++ L++E + L +++KE D E+
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQ---------------------ELEILKKEYDQER 1975
Query: 811 QEKHIKESKEKPEKRSQI---------------KEKDIEKMERKTFEKEKKIKHEHKSEK 855
+EK IK+ +E E + KE+++E ++T K ++++ E E
Sbjct: 1976 EEK-IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLES 2033
Query: 856 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH---- 911
+ + ++ + KI EKD T K ++E ++ K D + E++ +K+
Sbjct: 2034 HQEETNQLLKKIAEKDDDLK-RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092
Query: 912 -DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
+E P + + L +K SD SK ++ + +E+ L+ + K +K
Sbjct: 2093 EQEENPGNDNVTIMELQTQLAQKTTLISD----SKLKEQEFREQIHNLEDRLKKYEK 2145
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 98.2 bits (243), Expect = 7e-20
Identities = 191/946 (20%), Positives = 381/946 (40%), Gaps = 139/946 (14%)
Query: 329 ENIDSETEKDSLICES----KQILPSKTPLPSALDEYEFKD--DDDEEINKMIDD-RHIL 381
EN+ +E E+ + E+ KQ L K A + K + ++E+ +M + R
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 382 RKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST 441
+ +Q+K E E E L A+ A ++ L SS S EE + K
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPA------GDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 442 SCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGK-----E 496
+ S ++ S+ + E V +H+ +G V ++ + K + + +EG E
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 497 NTRITNLTVNTGLDCSEKTREEGNFR----KSFSPKDDTSLHLFHISTGKSPKHSCGLSE 552
+L+++T CSE + K FS D+ + +L I K + GL E
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK--ERIAGLEE 1854
Query: 553 -----KQSTPLKQEHTKTCLSPGSSE----MSLQPDLVRYDNTESEFLPESSSVKSCKHK 603
K+ + + T LS S++ LQ ++ + + + E S V K K
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT--KLK 1912
Query: 604 EKSKHQKDFHLE----------------FGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
E ++ +KD E + ++A+IK+E +N + ++++E
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEK 1972
Query: 648 KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 707
+ L K K K + ++++ ++I+G +++ K AKELQ E KE K E +
Sbjct: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ-------ELLKE---KQQEVK 2022
Query: 708 DLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEKSF 762
L + EK S LE+ +K +S K+ ++KE + + K ++E +
Sbjct: 2023 QLQKDCIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 763 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK-----QEKHIKE 817
+ + D + E + D + + +ES+ + +K+ D+E+ +EKH+KE
Sbjct: 2080 FKVLLDDTQSEAARVLADNLK--LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137
Query: 818 SKEKPEKRSQIKEKDIEKME-----RKTFEKEKKIKHEHKSEKDKL-------------- 858
K EK ++ + + E + T K+ K + + D
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197
Query: 859 --DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP 916
D +D+ K+ ++ +S + +E ++ ++ K R+ S + K + +
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 917 EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
E ++ + ESK + ++ + K D + G+NKE +L++ ++
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQ------GENKELLSQLEE--------------TR 2297
Query: 977 HIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKD 1035
H+ ++ + A+ E L SLK++ D KE+ + I R +E D
Sbjct: 2298 HLYHSSQNEL-----AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 1036 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1095
K S +L+++ + +S ++ KE+++++ + + E + + E+ Q H
Sbjct: 2353 KF---SYEQLETDLQASRELTSRLHEEINMKEQKIIS---LLSGKEEAIQVAIAELRQQH 2406
Query: 1096 KKH-KEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKE- 1153
K KE +E N E K +KT K + + D++ K
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 1154 ---KQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
+ +D + Q ++ +++ S + + L + +EN K
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHL-----SIILEKDQLIQEAAAENNK 2507
Score = 86.7 bits (213), Expect = 2e-16
Identities = 194/996 (19%), Positives = 393/996 (39%), Gaps = 132/996 (13%)
Query: 369 EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 428
++I + + I RKE KEN+ E+ L + + KS S+V + E
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSL----ARGTIERLTKSLADVESQVSAQNKEK 1534
Query: 429 S--------------------DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
D L+N+ +S+SC + + K++ V E +
Sbjct: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
Query: 469 KGKVKRKLKNQNKNKENQE------LKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 522
K+ + Q K+KE Q+ E E RI ++ EK G R
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR---QEKQELYGKLR 1651
Query: 523 KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 582
+ + K +T L +E++ +K++ K S + L+ +
Sbjct: 1652 STEANKKETEKQLQE-------------AEQEMEEMKEKMRKFAKSKQQKILELEEE--- 1695
Query: 583 YDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKK 642
D +E P + K C +E SNA +K+E E +
Sbjct: 1696 NDRLRAEVHPAGDTAKEC-------------METLLSSNASMKEE-----LERVKMEYET 1737
Query: 643 MDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFK 702
+ K+ ++L K E E + K +IEG K ++ ++ E +
Sbjct: 1738 LSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS---I 1793
Query: 703 SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-------RNFKEERDKIK 755
ETE E +SL++ + +++ KS VSK+ N+ ++ D++K
Sbjct: 1794 PGETE------EQDSLSMSTRPTCSESVPSAKSANPA-VSKDFSSHDEINNYLQQIDQLK 1846
Query: 756 K-----ESEKSFREEKIKDLKEERENIPTD---KDSEFTSLGMSAIEESIGLHLVEKEID 807
+ E EK +E + L+ E+ + + KD E L + ++ +++E+
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906
Query: 808 -IEKQEKHIKESKEKPEKR--SQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 864
+ K ++ +E K+ E+R +Q+ E + + +IK+E E + +L +CV
Sbjct: 1907 RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE-LLESEMKNLKKCV 1965
Query: 865 DKIKEKDKLYSHHTEKCHKEGEK---SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
+++E+ + K E K K A K+ ++ ++E + +K++ K+
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
Query: 922 LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE-LDKKEKSRDKESINITNSKHIQE 980
+ + + + E+ ++E K+ E +E L + + R K + + K + +
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 981 EKKSS---IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1037
+ +S ++ N ++ S KE K + + + E+ + + KE+ ++K+
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE------RMLSLKD--- 1088
K+ E + + + KD KE + + ++L T + M SL+D
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKD---KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRD 2202
Query: 1089 ---LEIEQWHKKHKEKIKQKEKE-RLRNRNCLELKIKDKEKTKHTPTESKN-KELTRSKS 1143
E ++W +K + I+ KE+E RL+ NC LK + ++ + H N L K
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 1144 SEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENE----KPGL 1199
+ A T E Q + V + Q + + + L ++ + +S N + E+E K L
Sbjct: 2263 IWESKAQT-EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321
Query: 1200 SSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALH 1259
+ S S+ + + + ++ +S F E E+ + S+ + + +
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEADIQ-NSKFSYEQLETDLQASRELTSRLHEEINMK 2380
Query: 1260 ERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVK 1295
E+++ SL E A +++ + LR +++K
Sbjct: 2381 EQKIISLLSGKEE-----AIQVAIAELRQQHDKEIK 2411
Score = 70.5 bits (171), Expect = 2e-11
Identities = 190/912 (20%), Positives = 356/912 (39%), Gaps = 148/912 (16%)
Query: 314 TDSEEAQSVNPSSVDENIDSETEK-DSLICESKQILPSKTPLPSALDEYEFKD-DDDEEI 371
T+ + Q+ ++I ETE+ DSL ++ P + + KD +EI
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
Query: 372 NKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDE 431
N + L KE+ E E +K K F + L S + D
Sbjct: 1836 NNYLQQIDQL-KERIAGLEEEKQKN------------KEFSQTLENEKNTLLSQISTKDG 1882
Query: 432 EA-----------LQNKKISTSCSVIP---ETSNSDMQTKKEYVVSGEHKQKGKVKRKLK 477
E L N++I S + ET+ + +E +++ + G + +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942
Query: 478 NQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFH 537
+ + EL + + ++ L EKT+ E RK + K
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQ------- 1995
Query: 538 ISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSV 597
K P + E Q LK++ + LQ D +RY S +V
Sbjct: 1996 -GAQKEPGNKSHAKELQEL-LKEKQQEV--------KQLQKDCIRYQEKISAL---ERTV 2042
Query: 598 KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 657
K+ + + ++ QKD + + A + + L E + LK
Sbjct: 2043 KALEFVQ-TESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 658 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHE- 716
K +E + +K+ ++ + K K +D + L+++ E + K K D +++E
Sbjct: 2102 K-KELQSNKESVKSQM-KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Query: 717 ---SLTLEKKSK----LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 769
+TL KK K L++N+ + + +++RD++ E++K E K D
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW--ERKFSD 2217
Query: 770 LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEKRSQ 827
+ +E K+ + L + SI H+ E +I+I + E K I ESK + E + Q
Sbjct: 2218 AIQSKEEEIRLKEDNCSVLKDQLRQMSI--HMEELKINISRLEHDKQIWESKAQTEVQLQ 2275
Query: 828 IKEKDIEKMERKTFEKE---------------KKIKHEHKSEKDKL-DLSECVDKIKEK- 870
K D + E K + K++ E KS KD+L DLS ++K KE+
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335
Query: 871 ---------------DKLYSHH------------TEKCHKEGEKSKNTAAIKKTDDREKS 903
+ +S+ T + H+E K I +E++
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE-INMKEQKIISLLSGKEEA 2394
Query: 904 RE----KMDRKHDKEKPEKERHLAESKEKHLM---------EKKNKQSDNSEYSKSEKGK 950
+ ++ ++HDKE E E L++ +E++++ +K N+ E K+ K +
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL---METLKTIKKE 2451
Query: 951 NKEKDRELDKKEKS-----RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL---SLKE 1002
N ++ +LD KS D++ I + + + ++E S I++ ++ E LKE
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRI-VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 1003 KTKDEPLKTPD-GKEKDKKDKDIDRYKERDKH----KDKIQINSLLKLKSEADKPKPKSS 1057
+ + D E K D ++ +Y+E KD Q LL+++ + +K + ++
Sbjct: 2511 EIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS-QQKQLLEVQLQQNK-ELENK 2568
Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDL--EIEQWHKKHKEKIKQ---KEKERLRN 1112
A + + KE N+DL ++ +DL EIE + +Q ++E
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 1113 RNCLELKIKDKE 1124
+LK+K++E
Sbjct: 2629 LYHAQLKVKEEE 2640
Score = 52.0 bits (123), Expect = 6e-06
Identities = 245/1292 (18%), Positives = 468/1292 (36%), Gaps = 222/1292 (17%)
Query: 51 EMKEKSSMKRKLPFTISPSRN-EERDSDTDSDPGHTS---ENWGERLISSYRTYSEKEGP 106
E K K+ M+ K +S + +E S D+ S ++ E+ + S +T + E
Sbjct: 367 EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426
Query: 107 EKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKK 166
++K+K+ + L PL + + TA S N +Q +
Sbjct: 427 LQQKSKEIS--------QFLNRLPLQQHE--------TASQTSFPDVYNEGTQAVTEE-- 468
Query: 167 TPSSSSRQKDKVNKRNERGE---TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLH 223
+ +S QK V NE+G + + + ++ + +++ I+L N A
Sbjct: 469 --NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD----R 522
Query: 224 EACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNP------ 277
E + D+A + G D L ++ S H+++ LLL
Sbjct: 523 EVSEISIVDIAN---KRSSSAEESGQD---VLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
Query: 278 ---FQANKHGERPVDVAETEELELL-------LKREVPLSDDDESYTDSEEAQSVNPSSV 327
Q + E +V + +E++ + +K +V L D + + +S P+
Sbjct: 577 KLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE 636
Query: 328 DENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRK 387
E + TE S E + + L S K D D+ ++ + D + E +
Sbjct: 637 KEQ--ASTEHQSRTSEEISLNDAGVELKST------KQDGDKSLSAVPDIGQCHQDELER 688
Query: 388 ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIP 447
E F K ++ Y K+ K ++ S L E + A N T+ S
Sbjct: 689 LKSQILELELNFHKAQE-IYEKNLDEKAKEISN-LNQLIEEFKKNADNNSSAFTALS--E 744
Query: 448 ETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 507
E Q K+ +V+ + + +VK+ N + + + L E + + +T +
Sbjct: 745 ERDQLLSQVKELSMVT---ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801
Query: 508 GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 567
++ K + + DD L ST S L K+S L+ +
Sbjct: 802 SIEAKSKDVKIEVLQNEL---DDVQLQFSEQSTLIRSLQS-QLQNKESEVLEGAERVRHI 857
Query: 568 SPGSSEMS--LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG-EKSNAKI 624
S E+S L + + L + V++ + + K Q+ + F + ++
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 625 KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIE-------GEKEKYK 677
+E S + E KTLK+ +L R +E K+++E G K+ Y
Sbjct: 918 NEEKFS------------LGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 678 TKDSAKELQRSVEFDREF---WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD-- 732
A ++ + E EF KEN + + + +N + L++ S+LE+ + +
Sbjct: 965 EMSPAGQISKE-ELQHEFDLLKKENEQRKRKLQAALINRKE---LLQRVSRLEEELANLK 1020
Query: 733 DKSTKEKHVSKERNFKEERDKIKKE----------------------------------- 757
D+S KE +S+ + E DK KE
Sbjct: 1021 DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 758 SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI----------------GLHL 801
EK EE+ + L ++ DK ++ L E + L
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 802 VEKEIDI-------------EKQEKHIKESKEKPEKRSQIKEKDIEKME--RKTFEKEKK 846
V++ + I E +EK + KEK + + +++E + +K EKE+
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 847 IKHEHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSRE 905
++ E K +KD + L E D+ ++++ + + +S + + TD +E
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESID-GKLPSTDQQESCSS 1259
Query: 906 KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSR 965
+ K ++ H E +L +SE + + +G + KE
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCP---DWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 966 DKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDID 1025
+K + + S E K S E+ L+E+ + L+ K + +
Sbjct: 1317 EKVELELKVSSTTSELTKKS---------EEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 1026 RYKERDKHKDKIQI---NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE- 1081
++ ++QI L +L+ + D+ + S +D +L + T +
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 1082 RMLSLKDL------EIEQWHKKHKEKIKQ--------KEK-----ERLRNRNCLELK--- 1119
++ +DL ++E K+H E+IKQ K+K E R + ++ K
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 1120 --IKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGK 1177
I KE K + + L R +T + + VS +++ DT LG+
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLA---DVESQVSAQNKEKDT----VLGR 1540
Query: 1178 SSFVS---DNSLNRSPRSENEKPGLSSRSVSM 1206
+ + D + RS E LSS S+
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQSLSSSCESL 1572
Score = 49.3 bits (116), Expect = 4e-05
Identities = 84/411 (20%), Positives = 170/411 (41%), Gaps = 52/411 (12%)
Query: 823 EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 882
E + I++KD++ ++ +E++ ++K +K KL K K + + E+
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA-------KAKLTSLNKYIEEMK 115
Query: 883 KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD-NS 941
+G T E E+ KHDK E+E + + K K L EK+ S +
Sbjct: 116 AQGGTVLPT---------EPQSEEQLSKHDKSSTEEEMEIEKIKHK-LQEKEELISTLQA 165
Query: 942 EYSKSEKGKNKEKDRELDK----KEKSRDKESINITNSKHIQ----EEKKSSIVDGNKAQ 993
+ ++++ + + E+++ K++ ++KE T + E+ +V A+
Sbjct: 166 QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDAR 225
Query: 994 HEKPLSLKEKTKDEPLK--TPDGKEKDKKDKDIDRYKERDKHKDKI-------------- 1037
E + L E DE L+ T E + + K ++ ++H++ +
Sbjct: 226 FETQVRLHE---DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282
Query: 1038 ----QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
Q N +L + + + + + + +T +E +++ + + ER LS +L+ E
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342
Query: 1094 WHKKHK-EKIKQKEKERLRNRNCLELKIKDK--EKTKHTPTESKNKELTRSKSSEVTDAY 1150
H + E+ Q + E + LE K K + EKT H + K + +S + D
Sbjct: 343 HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402
Query: 1151 TKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSS 1201
+K Q K+ + +S + L + S LNR P ++E +S
Sbjct: 403 SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453
Score = 48.1 bits (113), Expect = 9e-05
Identities = 105/605 (17%), Positives = 239/605 (39%), Gaps = 78/605 (12%)
Query: 631 PTFENSDCTLKKMDKEG--KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 688
PT S+ L K DK + ++ K+KHK +EKE+ ++ + + + + A Q S
Sbjct: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA---QSS 179
Query: 689 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFK 748
E + F+ M+ + L++K + ++ S + + ++ +
Sbjct: 180 TEMEE----------------FVMMKQQ---LQEKEEFISTLQAQLSQTQAEQAAQQVVR 220
Query: 749 EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
E+ + E++ E+++ L + + + T+ + L E L + +D+
Sbjct: 221 EKDARF--ETQVRLHEDELLQLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 809 EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 868
+QE E+R+QI + +++ME + ++ E + K L+ E ++
Sbjct: 278 LQQE------LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL--EVA 329
Query: 869 EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHL------ 922
E+ + + E+ H E+ + + + E +++KH E EK H+
Sbjct: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQA--ELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 923 ----------AESKEKHLMEKKNKQSDNSEYSKSE-KGKNKEKDRELDK---KEKSRDKE 968
+ + L++ KN+Q+ S + + + + ++K +E+ + + + E
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 969 SINITNSKHIQEEKKSSIVDGNKA---------QHEKPLSLKEKTKDEPLKTPDGKEKDK 1019
+ + T+ + E ++ + N A ++EK L + E LK E +K
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA----ENEK 503
Query: 1020 KDKDI------DRYKERDKHKDKIQINSLL-KLKSEADKPKPKSSPASKDTRPKEKRLVN 1072
I +R E D+ +I I + K S A++ + + KE ++
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL 563
Query: 1073 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK-DKEKTKHTPT 1131
++ + E L+ ++ + E + QKE +++ +K+K E T
Sbjct: 564 LEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623
Query: 1132 ESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPR 1191
N+E + + + + + + +S V+ K+ G S + + + +
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 1192 SENEK 1196
E E+
Sbjct: 684 DELER 688
Score = 46.6 bits (109), Expect = 3e-04
Identities = 185/966 (19%), Positives = 379/966 (39%), Gaps = 174/966 (18%)
Query: 279 QANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKD 338
+A K + D +++E E+ LK D+ D S++ + NI S E D
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKE-----DNCSVLKDQLRQMSIHMEELKINI-SRLEHD 2260
Query: 339 SLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHL 398
I ESK ++ L + + + ++ E ++++ + RH+ Q + + E+E L
Sbjct: 2261 KQIWESKA--QTEVQLQQKVCD-TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317
Query: 399 FAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKK 458
K + S + K++ + E +QN K S E +D+Q +
Sbjct: 2318 --KDQLTDLSNSLEKCKEQKGNL--EGIIRQQEADIQNSKFSY------EQLETDLQASR 2367
Query: 459 EYVVSGEHKQKGKVKRKLKNQNKNKENQ------ELKQEKEGKENTRITNLTVNTGLDCS 512
E + S H++ ++K+ + KE EL+Q+ + KE + NL
Sbjct: 2368 E-LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD-KEIKELENLL-------- 2417
Query: 513 EKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGS- 571
EE N + K+ + L E T +K+E+ + S
Sbjct: 2418 -SQEEEENI-------------VLEEENKKAVDKTNQLMETLKT-IKKENIQQKAQLDSF 2462
Query: 572 --SEMSLQPDLVR----YDNTESEFLP---------ESSSVKSCKHKEKSKHQKDFHLEF 616
S SLQ D R Y E L + ++ ++ K KE+ + + H++
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS-HMDD 2521
Query: 617 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 676
NAK+ D + E+ + + D + K L + +L+ + + K+ K E KE
Sbjct: 2522 LNSENAKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE-- 2578
Query: 677 KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
++++ ++L+RS +E E +DL +E +++ + ++ ++++ +
Sbjct: 2579 -SEEANEDLRRSFNALQE----------EKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627
Query: 737 KEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEE 795
H K + +++ + S S +++I +L+EE + +++
Sbjct: 2628 GLYHAQ----LKVKEEEVHRLSALFSSSQKRIAELEEE----------------LVCVQK 2667
Query: 796 SIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
+ E E ++K+ KH+ ++ E+ + ++ R E E+K+ K K
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK 2727
Query: 856 ------------------DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK-NTAAIKK 896
+ +E +D++K K + ++G ++ A + +
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787
Query: 897 TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN----SEYSKSEKGKNK 952
T S E+ H EK SK++ L+ ++ D+ +SK+
Sbjct: 2788 TAFSMNSTEENSLSH----LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
Query: 953 EKD---RELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK------ 1003
E+D EL+K KS + + + E +S + Q+++ LKE
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2903
Query: 1004 --------TKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
T+ PLK +E K K +E + ++ + L +L+ E K
Sbjct: 2904 YLQINQEITELHPLKA-QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME------K 2956
Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE-KIKQKEKERLRNRN 1114
SS + R KE+ L+ +S KD ++ +E + + + L+
Sbjct: 2957 SSWEIHERRMKEQYLM-----------AISDKDQQLSHLQNLIRELRSSSSQTQPLK--- 3002
Query: 1115 CLELKIKDKEKTKHTPTESKN----KELTRSK-SSEVTDAYTKEKQPKDAVSNRSQSVDT 1169
++ + + +T +P S+N EL R++ + + + + KE + + SN SQ ++
Sbjct: 3003 -VQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061
Query: 1170 KNVMTL 1175
KN +++
Sbjct: 3062 KNTLSI 3067
Score = 43.9 bits (102), Expect = 0.002
Identities = 215/1158 (18%), Positives = 430/1158 (37%), Gaps = 136/1158 (11%)
Query: 720 LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
L ++S +E N + +E+ E+ E +D I+++ + ++K + L+EER+
Sbjct: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQL--QQKDEALQEERKAA-- 89
Query: 780 DKDSEFTSLGMSAIEESIGLHLVEKEIDIE-----KQEKHIKESKEKPEKRSQIKEKDIE 834
D++ L + A + L+ +E+ + E +E K +K S +E +IE
Sbjct: 90 --DNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
Query: 835 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 894
K++ K EKE+ I +++ + + E ++ + KE S A +
Sbjct: 148 KIKHKLQEKEELIS-TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206
Query: 895 KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
+T E++ +++ R+ D + E + L E + L+ + + +++ + + + K +E
Sbjct: 207 SQT-QAEQAAQQVVREKD-ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEH 264
Query: 955 DRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDG 1014
+ L + + D +T ++ + + S + +A+H + E ++E +
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQ-RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323
Query: 1015 KEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD 1074
E + ++ + H + +++ LL+ +A + + + K K
Sbjct: 324 MELEVAERKL------SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA----- 372
Query: 1075 LMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESK 1134
M+ +LSL+ E Q + L+++N L+ K+++ + T +
Sbjct: 373 EMEEKTSHILSLQKTGQE----------LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 1135 NKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSEN 1194
++ + KS E++ + + ++++ D N T + + R EN
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482
Query: 1195 EKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIA- 1253
EK L S+ + + + + + +T + + E+ S+ + IA
Sbjct: 483 EKGALLLSSIELEELKAENEKLSSQITL--------LEAQNRTGEADREVSEISIVDIAN 534
Query: 1254 -KSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSM 1312
+S + E D L N S H + + L + E + I + +
Sbjct: 535 KRSSSAEESGQDVL-----------ENTFSQKH---KELSVLLLEMKEAQEEIAFLKLQL 580
Query: 1313 PSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSF-AT 1371
E E +Q + + G+ K +VF +D + N SS A
Sbjct: 581 QGKRAEEADH-----EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
Query: 1372 SPTGASNSKYVSADRNLIKNTAPV---NTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLET 1428
AS + N A V +T D L +G + D LE
Sbjct: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG-------QCHQDELER 688
Query: 1429 LSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLS-LRQTELPGNSCAQDPASFMP 1487
L S I + E + K L E A +S L Q A + +S
Sbjct: 689 L--------KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSS--- 737
Query: 1488 PQQPCSFPSQSLSDAESISKHMSLSYVANQEPGI--LQQKNAVQIISSALDTDNESTKD- 1544
+F + S + +S+ LS V + L+ A LD ++++ D
Sbjct: 738 -----AFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
Query: 1545 --TENTFVLG-DVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDA-STQL 1600
TE L + + D + V + E++ + L S+ S+
Sbjct: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Query: 1601 NTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMP 1660
+ SK+ S + + E T + EK+ +E+L T + D + E++ M
Sbjct: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT-IEEKDQQVTEISFSMT 911
Query: 1661 KG--NLNEQ------DPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQ 1712
+ LNE+ + K E L E+ + +Q + + + EM GQ
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 1713 LVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIR 1772
+ K EL+ + K EN+ QR + +A + N+ + + L E + + I
Sbjct: 972 ISKEELQHEFDLLKKENE--QRKRKLQA-ALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 1773 LTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSER 1832
L+E + ++ ++ K + EK S K EI+ Y +
Sbjct: 1029 LSETERGEVEEDKENK---------------EYSEKCVTS--------KCQEIEIYLKQT 1065
Query: 1833 -ANPYFEYLHIRKKIEEK 1849
+ E HIRK +EEK
Sbjct: 1066 ISEKEVELQHIRKDLEEK 1083
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 98.2 bits (243), Expect = 7e-20
Identities = 162/896 (18%), Positives = 350/896 (39%), Gaps = 121/896 (13%)
Query: 324 PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 383
P S +EN++ ET +D ++ I Y++ + E+ + R +++
Sbjct: 135 PESEEENVEWETNRDD--SDNGDI------------NYDYVHELSLEMKRQKIQRELMKL 180
Query: 384 EQ-----------RKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEE 432
EQ +KE PE ++ L KS KS K+K S S+++ +
Sbjct: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLR---KSSKSPKRKSSPKSSSASKKDRKT 237
Query: 433 AL---------QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNK 483
+ +N K + S P T + ++ + ++K+K KVK +++ + +
Sbjct: 238 SAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR-- 295
Query: 484 ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKS 543
+GK+ R E+ RE+ + +S SP H S S
Sbjct: 296 ---------DGKDRGRDF-----------ERQREKRDKPRSTSPAGQ------HHSPISS 329
Query: 544 PKHSCGLSEKQSTPLKQEHT-----KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVK 598
HS S QS Q H+ K SP S + +L P L R S S S+
Sbjct: 330 RHHS---SSSQSGSSIQRHSPSPRRKRTPSP-SYQRTLTPPLRR-----SASPYPSHSLS 380
Query: 599 SCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHK 658
S + K+ + E G + + + H E + T K D+E + ++ + +
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTS-QSHDRRHERREDTRGKRDREKDSREEREYEQD 439
Query: 659 EREKEKHKKEIE-----GEKEKYKTKD-----SAKELQRSVEFDREFWKENFFKSDETED 708
+ H+ + E ++ T+D +++++ S E R++ ++ D +
Sbjct: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREM-RDYSRDTKESRDPRDS 498
Query: 709 LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
H+ E + K ++ +S H+ +E + E R++ + ES R +
Sbjct: 499 RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND 558
Query: 766 KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKR 825
++ + +P + + + H D + E PE+
Sbjct: 559 RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYH------DSWETRSSYPERDRYPERD 612
Query: 826 SQIKEKDIEKMERKTFEKEKKIKHE----------HKSEKDKLDLSECVDKIKEKDKLYS 875
++ + +D ER+ E++++ E H+ D+L+ E ++ + D++
Sbjct: 613 NRDQARD-SSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE-RRVDRVDD 670
Query: 876 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
E+ + + + ++ +RE+ RE+ + + + +ER KE+ ++
Sbjct: 671 RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730
Query: 936 KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
+ D + E+ + KE++RE +++E+ R++E + + E++ + + + +
Sbjct: 731 RDHDRERERERERDREKEREREREERERERERER---ERERERERERERARERDKERERQ 787
Query: 996 KPLSLKEKTKDEPLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLKSEADKPKP 1054
+ K+K +D+ + + +D+ +D D K + +++++ + K +
Sbjct: 788 RDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPD 847
Query: 1055 KSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1114
+ S D + ++ RL++ +++ R LS L ++ + +E K + KE R
Sbjct: 848 SDAYNSGDDKNEKHRLLS-QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
Query: 1115 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1170
EL KEK + + E+ S D + S+R+ + K
Sbjct: 907 EQEL----KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKK 958
Score = 87.4 bits (215), Expect = 1e-16
Identities = 143/799 (17%), Positives = 317/799 (39%), Gaps = 138/799 (17%)
Query: 396 THLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQ 455
+H + ++ P +S ++ R + T S + + ++ + + S + +
Sbjct: 376 SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE 435
Query: 456 TKKEYVVSGEHKQKGKVK--RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSE 513
+++ S +H+ + + R ++ ++ +EL+ ++ +++ + D S
Sbjct: 436 YEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR--------DYSR 487
Query: 514 KTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP-----LKQEHTKTCL- 567
T+E + R S S +D H + G+ ++S L++E ++T +
Sbjct: 488 DTKESRDPRDSRSTRD---AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
Query: 568 --SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIK 625
S S ++ D + LPE S + + + H + + ++ +
Sbjct: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGS-RGSRGSQIDSHSSNSNYHDSWETRSSYP 603
Query: 626 DEDHSPTFENSDCTL----------------KKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
+ D P +N D ++ D+ + +H+ ++ E E+++ ++E
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
Query: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
++ + + A+E R E DRE +E E E
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERER--------------ERE------------- 696
Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
+D + KE+ + +ER + ER++ E E+ ++ +D ERE
Sbjct: 697 -RDREREKERELERERARERERER---EKERDRERDRDRDHDRERER------------- 739
Query: 790 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
E+E D EK+ + +E +E+ +R + +E++ E+ + E++K+ +
Sbjct: 740 -------------ERERDREKEREREREERERERERERERERERERERERARERDKERER 786
Query: 850 EHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK 906
+ E K + D E ++I+E H E+ K+ +++ + + +++ R +
Sbjct: 787 QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
Query: 907 MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRD 966
++ + E+H S+ + ++++ S ++ +G+ KE+DR+ ++KE SR
Sbjct: 847 DSDAYNSGDDKNEKHRLLSQV--VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRR 904
Query: 967 KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD-------EPLKTPD-GKEKD 1018
E + ++K S VD + Q E S + + +D E +T D +++
Sbjct: 905 YEEQEL--------KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDEN 956
Query: 1019 KKDKDIDRYKERDKHKDKIQI--NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLM 1076
KK I + + K +D + I ++ + PK K K K+ D
Sbjct: 957 KKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDS-- 1014
Query: 1077 QTSFERMLSLKDLEIEQWHKKHK----EKIKQKEK--ERLRNRNCLELKIKDKEKTKHTP 1130
+ D E Q KK + I KE+ E +N + ++D +K + T
Sbjct: 1015 --------DISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI---LEDSQKKEDTA 1063
Query: 1131 TESKNKELTRSKSSEVTDA 1149
+ E + +EVT+A
Sbjct: 1064 FSDWSDEDVPDR-TEVTEA 1081
Score = 57.0 bits (136), Expect = 2e-07
Identities = 101/543 (18%), Positives = 204/543 (37%), Gaps = 63/543 (11%)
Query: 728 KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDS--EF 785
KN + D T+ + +RN +E ++KES + EK +D+K +E P ++ E+
Sbjct: 90 KNKRQDVDTEPQ----KRNTEESSSPVRKESSRGRHREK-EDIKITKERTPESEEENVEW 144
Query: 786 TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEK 845
+ + I V E+ +E + + I ++++ K+E++ EK +
Sbjct: 145 ETNRDDSDNGDINYDYVH-ELSLEMKRQKI--------------QRELMKLEQENMEKRE 189
Query: 846 K--IKHEHKSE--KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK--TDD 899
+ IK E E + KL S + K + K S + K +K + T+A+ D
Sbjct: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKS--SPKSSSASKKDRKTSAVSSPLLDQ 247
Query: 900 REKSREKMDRKHDKEKPEKERHLAE--SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 957
+ S+ +K P + E + K EK + E ++ K + ++ +R+
Sbjct: 248 QRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQ 307
Query: 958 LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT------------- 1004
+K++K R +S SS G+ Q P +++T
Sbjct: 308 REKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPL 367
Query: 1005 -------KDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1057
L +P K+ + + R K R H+ Q + + E + K
Sbjct: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK---R 424
Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
KD+R +E+ D +D + + +++ + ++ +R+ +
Sbjct: 425 DREKDSR-EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR 483
Query: 1118 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGK 1177
+D ++++ ++ + E D + KE D S+S ++
Sbjct: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKE----DTYPEESRSYGRNHLREESS 539
Query: 1178 SSFVSDNSLNRSPRSE--NEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFML 1235
+ + + S N S RSE N++ G S V + S S + + + Y +
Sbjct: 540 RTEIRNESRNES-RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
Query: 1236 ESS 1238
SS
Sbjct: 599 RSS 601
Score = 52.4 bits (124), Expect = 5e-06
Identities = 149/827 (18%), Positives = 311/827 (37%), Gaps = 114/827 (13%)
Query: 360 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 419
E E + + D E ++ D +E+ ++ E E E+ ++E+ + + ++++
Sbjct: 716 EREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERE 775
Query: 420 RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 479
R E + ++K + D + K+E + + + G +RK K +
Sbjct: 776 RARERDKERERQRDWEDK----------DKGRDDRREKREEIREDRNPRDGHDERKSKKR 825
Query: 480 NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIS 539
+N+ + +Q + + + N+G D +EK R + P++ SL
Sbjct: 826 YRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRL---LSQVVRPQESRSL------ 876
Query: 540 TGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS 599
SP H L+E + K+E K P E S RY+ E E + SSV
Sbjct: 877 ---SPSH---LTEDRQGRWKEEDRK----PERKESSR-----RYE--EQELKEKVSSV-- 917
Query: 600 CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
+K + Q + LE I S E SD + K+ K KK K KE
Sbjct: 918 ----DKQREQTEI-LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972
Query: 660 REKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESL 718
+ + IE E + K + ++S+E R+ K + SDE E+
Sbjct: 973 DDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDE----------EAA 1022
Query: 719 TLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIP 778
KK + + +TKE+ V + +K+ + +F + +D+ + E
Sbjct: 1023 QQSKKKRGPRT--PPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
Query: 779 TDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE---- 834
+ + T+ G + S L + + I
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS 1140
Query: 835 ----KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKI---------KEKDKLYSHHTEKC 881
TF E + H++ +K++ + K L S+ + +
Sbjct: 1141 ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS 1200
Query: 882 HKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
H G +S + + ++ D + R+++ +++ K K L ++S
Sbjct: 1201 HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR---------EKTKSLEITGERKSRI 1251
Query: 941 SEYSKSEKGKNKEKDRELDKKEKSR--DKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 998
+ + E ++ DR+ + SR ES +S+ + + + + ++ +H++
Sbjct: 1252 DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRE- 1310
Query: 999 SLKEKTKDEPLKTPDGKEKDK---KDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
+E+ + + + ++ DK +++D DR +ER++ + E DK
Sbjct: 1311 --RERERRDTRQREWDRDADKDWPRNRDRDRLRERERER-------------ERDK---- 1351
Query: 1056 SSPASKDTRPKEKRLVNDDL-MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1114
+D + +RL++D + +R + + +IE K+ + K++ + + L + +
Sbjct: 1352 ----RRDLDRERERLISDSVERDRDRDRDRTFESSQIES-VKRCEAKLEGEHERDLESTS 1406
Query: 1115 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVS 1161
L + + K + +E +S+ +E +A E + DA S
Sbjct: 1407 RDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHS 1453
Score = 46.6 bits (109), Expect = 3e-04
Identities = 123/676 (18%), Positives = 255/676 (37%), Gaps = 90/676 (13%)
Query: 317 EEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMID 376
+E++S++PS + E+ +++ E K+ S+ L E D E ++++
Sbjct: 871 QESRSLSPSHLTEDRQGRWKEEDRKPERKE--SSRRYEEQELKEKVSSVDKQREQTEILE 928
Query: 377 DRHILRKE----QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTE--SSD 430
+ ++ + E+ +++ H K++ K K KK+ + + E S D
Sbjct: 929 SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988
Query: 431 EEALQNKKISTSCSVIPETSNS--DMQTKKEYVVSGEHKQKGK------VKRKLKNQNKN 482
+ KK S+ + S D E K++G K +L
Sbjct: 989 GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048
Query: 483 KENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGK 542
K + ++ + KE+T ++ + D +E T E + + T L +
Sbjct: 1049 KNG--ILEDSQKKEDTAFSDWSDEDVPDRTEVT--EAEHTATATTPGSTPSPLSSLLPPP 1104
Query: 543 SPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH 602
P + + +T L S +S +++ + T + F E S K H
Sbjct: 1105 PPVATATATTVPAT-LAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKC--H 1161
Query: 603 KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF-----------------ENSDCTLKKMDK 645
+ + + + H+ + + K D+ S + N D+
Sbjct: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQ 1221
Query: 646 EGKTLKKHKLKHKEREKEKHKK-EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
G+ K L R++EK K EI GE++ + E RS DR+ + + +
Sbjct: 1222 SGR---KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRS 1278
Query: 705 ETEDLFLNMEHESLTLEKKSKLEKNIK---DDKSTKEKHVSKERNFKEERDKI------- 754
E + S + + + +L++ + D + +E+ +++R + + DK
Sbjct: 1279 SPES-DRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR 1337
Query: 755 --KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 812
+E E+ +K +DL ERE + +D VE++ D ++ +
Sbjct: 1338 DRLRERERERERDKRRDLDRERERLISDS--------------------VERDRDRDR-D 1376
Query: 813 KHIKESKEKPEKRSQIK-----EKDIEKMERKT--FEKEKKIKH----EHKSEKDKLDLS 861
+ + S+ + KR + K E+D+E R + +KE+ K + E +K + +
Sbjct: 1377 RTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERT 1436
Query: 862 ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
E ++ ++ KL H+ GE + + + + EK + + D+EK
Sbjct: 1437 ESLEAGDDESKLDDAHS-LGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLD 1495
Query: 922 LAESKEKHLMEKKNKQ 937
+ + LM K K+
Sbjct: 1496 VIDVDWSGLMPKHPKE 1511
Score = 42.0 bits (97), Expect = 0.006
Identities = 40/212 (18%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 861 SECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKS--REKMDRKHDKEKPE 917
++C + +K + LY + H + K ++ +++ +R RE+M K E
Sbjct: 40 TQCRNWLKTGNCLYGNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTE 99
Query: 918 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 977
++ + ++S + +S +G+++EK+ KE++ + E N+ +
Sbjct: 100 PQK------------RNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147
Query: 978 IQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1037
+ I HE L +K + L + + +K+++ I + KE +
Sbjct: 148 RDDSDNGDI--NYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK-KEVSPEVVRS 204
Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1069
+++ L+ + PK KSSP S K+++
Sbjct: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
Score = 33.9 bits (76), Expect = 1.7
Identities = 39/199 (19%), Positives = 80/199 (40%), Gaps = 27/199 (13%)
Query: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1059
+K K +D + P + ++ + + R +H++K I + E+++ +
Sbjct: 89 MKNKRQDVDTE-PQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147
Query: 1060 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1119
D+ + +N D + +L +E +K + ++ + E+E + R + +K
Sbjct: 148 RDDSDNGD---INYDYVH----------ELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194
Query: 1120 IKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSS 1179
+ + E+ RSK S K PK S +S S K+ T SS
Sbjct: 195 ------------KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSS 242
Query: 1180 FVSDNSLNRSPRSENEKPG 1198
+ D N S ++++K G
Sbjct: 243 PLLDQQRN-SKTNQSKKKG 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,005,312
Number of Sequences: 37866
Number of extensions: 4293264
Number of successful extensions: 51086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 1595
Number of HSP's that attempted gapping in prelim test: 15398
Number of HSP's gapped (non-prelim): 15873
length of query: 2062
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1944
effective length of database: 13,779,330
effective search space: 26787017520
effective search space used: 26787017520
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.