Guide to the Human Genome
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Search of human proteins with 134948558

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
         (2062 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]       4096   0.0  
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]       4034   0.0  
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                   523   e-148
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]            133   2e-30
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]       128   5e-29
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]       128   5e-29
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]       128   5e-29
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   111   8e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   110   1e-23
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    109   2e-23
gi|87299628 biorientation of chromosomes in cell division 1-like...   104   1e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   103   2e-21
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   103   2e-21
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...   103   2e-21
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...   103   2e-21
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]       103   2e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   102   3e-21
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   102   4e-21
gi|148746195 trichohyalin [Homo sapiens]                              102   4e-21
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho...   101   7e-21
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   100   1e-20
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 100   2e-20
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...   100   3e-20
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    99   3e-20
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    99   3e-20
gi|221219020 NYD-SP11 protein [Homo sapiens]                           99   6e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    99   6e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     99   6e-20
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    98   7e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        98   7e-20

>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 4096 bits (10624), Expect = 0.0
 Identities = 2062/2062 (100%), Positives = 2062/2062 (100%)

Query: 1    MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
            MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1    MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60

Query: 61   KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
            KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS
Sbjct: 61   KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120

Query: 121  TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
            TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK
Sbjct: 121  TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180

Query: 181  RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
            RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA
Sbjct: 181  RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240

Query: 241  GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
            GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL
Sbjct: 241  GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300

Query: 301  KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
            KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE
Sbjct: 301  KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360

Query: 361  YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
            YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR
Sbjct: 361  YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420

Query: 421  VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
            VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN
Sbjct: 421  VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480

Query: 481  KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
            KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST
Sbjct: 481  KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540

Query: 541  GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
            GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC
Sbjct: 541  GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600

Query: 601  KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
            KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER
Sbjct: 601  KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660

Query: 661  EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
            EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL
Sbjct: 661  EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720

Query: 721  EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
            EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD
Sbjct: 721  EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780

Query: 781  KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
            KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT
Sbjct: 781  KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840

Query: 841  FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
            FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR
Sbjct: 841  FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900

Query: 901  EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
            EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK
Sbjct: 901  EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960

Query: 961  KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
            KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK
Sbjct: 961  KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020

Query: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
            DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF
Sbjct: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080

Query: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
            ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR
Sbjct: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140

Query: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
            SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS
Sbjct: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200

Query: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
            SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE
Sbjct: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260

Query: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
            RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
Sbjct: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320

Query: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
            KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK
Sbjct: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380

Query: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
            YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN
Sbjct: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440

Query: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
            IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS
Sbjct: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500

Query: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
            DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF
Sbjct: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560

Query: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
            VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE
Sbjct: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620

Query: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
            NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL
Sbjct: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680

Query: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
            SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA
Sbjct: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740

Query: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
            NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP
Sbjct: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800

Query: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
            SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA
Sbjct: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860

Query: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
            PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE
Sbjct: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920

Query: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
            REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR
Sbjct: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980

Query: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
            FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI
Sbjct: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040

Query: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
            YEIQEFYVPLVDVNDDFELTPI
Sbjct: 2041 YEIQEFYVPLVDVNDDFELTPI 2062


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 4034 bits (10462), Expect = 0.0
 Identities = 2039/2062 (98%), Positives = 2039/2062 (98%), Gaps = 23/2062 (1%)

Query: 1    MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
            MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR
Sbjct: 1    MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60

Query: 61   KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
            KLPFTISPSRNEERDSDT                       EKEGPEKKKTKKEAGNKKS
Sbjct: 61   KLPFTISPSRNEERDSDT-----------------------EKEGPEKKKTKKEAGNKKS 97

Query: 121  TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180
            TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK
Sbjct: 98   TPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 157

Query: 181  RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 240
            RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA
Sbjct: 158  RNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAA 217

Query: 241  GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
            GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL
Sbjct: 218  GADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLL 277

Query: 301  KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
            KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE
Sbjct: 278  KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 337

Query: 361  YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
            YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR
Sbjct: 338  YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 397

Query: 421  VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
            VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN
Sbjct: 398  VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 457

Query: 481  KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 540
            KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST
Sbjct: 458  KNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIST 517

Query: 541  GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 600
            GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC
Sbjct: 518  GKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSC 577

Query: 601  KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 660
            KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER
Sbjct: 578  KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKER 637

Query: 661  EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
            EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL
Sbjct: 638  EKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 697

Query: 721  EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
            EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD
Sbjct: 698  EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 757

Query: 781  KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
            KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT
Sbjct: 758  KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 817

Query: 841  FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 900
            FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR
Sbjct: 818  FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR 877

Query: 901  EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 960
            EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK
Sbjct: 878  EKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK 937

Query: 961  KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 1020
            KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK
Sbjct: 938  KEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKK 997

Query: 1021 DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1080
            DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF
Sbjct: 998  DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSF 1057

Query: 1081 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1140
            ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR
Sbjct: 1058 ERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTR 1117

Query: 1141 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1200
            SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS
Sbjct: 1118 SKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLS 1177

Query: 1201 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1260
            SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE
Sbjct: 1178 SRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHE 1237

Query: 1261 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1320
            RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT
Sbjct: 1238 RELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHT 1297

Query: 1321 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1380
            KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK
Sbjct: 1298 KQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSK 1357

Query: 1381 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1440
            YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN
Sbjct: 1358 YVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSN 1417

Query: 1441 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1500
            IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS
Sbjct: 1418 IPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLS 1477

Query: 1501 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1560
            DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF
Sbjct: 1478 DAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAF 1537

Query: 1561 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1620
            VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE
Sbjct: 1538 VPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVE 1597

Query: 1621 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1680
            NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL
Sbjct: 1598 NSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLL 1657

Query: 1681 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1740
            SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA
Sbjct: 1658 SIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKA 1717

Query: 1741 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1800
            NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP
Sbjct: 1718 NTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSP 1777

Query: 1801 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1860
            SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA
Sbjct: 1778 SLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQA 1837

Query: 1861 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1920
            PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE
Sbjct: 1838 PQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIE 1897

Query: 1921 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1980
            REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR
Sbjct: 1898 REKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDR 1957

Query: 1981 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2040
            FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI
Sbjct: 1958 FNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISI 2017

Query: 2041 YEIQEFYVPLVDVNDDFELTPI 2062
            YEIQEFYVPLVDVNDDFELTPI
Sbjct: 2018 YEIQEFYVPLVDVNDDFELTPI 2039


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score =  523 bits (1346), Expect = e-148
 Identities = 466/1437 (32%), Positives = 697/1437 (48%), Gaps = 225/1437 (15%)

Query: 1    MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKR 60
            MPK G  K  Q E     S+MVEK  G+K KDK+ S +KTPK+ER D  KE++E++S KR
Sbjct: 1    MPKGGCPKAPQQEELPLSSDMVEKQTGKKDKDKV-SLTKTPKLERGDGGKEVRERAS-KR 58

Query: 61   KLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKS 120
            KLPFT   +  E++DSDT                       EK+GPE+K+ KKE   +K+
Sbjct: 59   KLPFTAG-ANGEQKDSDT-----------------------EKQGPERKRIKKEPVTRKA 94

Query: 121  TPV------SILFGYPLSERKQMALLMQMTARD--NSP-DSTPNHPSQTTPAQKKTPSSS 171
              +       I  GYPLSER+Q+ALLMQMTA +  NSP D+TP HPSQ+T  QK TP+S+
Sbjct: 95   GLLFGMGLSGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSA 154

Query: 172  SRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYY 231
            S+ KDKVNKRNERGET LH AAIRGD +++KELIS GA+VNVKDFAGWT LHEACN GYY
Sbjct: 155  SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214

Query: 232  DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
            DVAK L+AAGA+VNT+GLDDDTPLHD+A++GH  +VKLLLR+GGNP Q+N+ GE P+ VA
Sbjct: 215  DVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA 274

Query: 292  ETEELELLLKREVPLSDDDESYTDS---EEAQSVNP-SSVD-ENIDSETEKDSLICESKQ 346
             +  +  LL  +   +  +ES T+S   E+A S  P SSVD  N DSE EK  L  ++K 
Sbjct: 275  NSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEK-GLKHKAKN 333

Query: 347  ILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
              P K   P   DEYEF +DD+++    +DD+H+L+K+ RKE +  +  +    K E   
Sbjct: 334  PEPQKATAP-VKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFIS--IPKMEVKS 390

Query: 407  YPKSFKSKKQKPSRVLYSSTESSDEEAL---QNKKISTSC-SVIPETSNSDMQTKKEYVV 462
            Y K+     +K S  + S T   ++ ++     +K+  S  +++P +   +    K    
Sbjct: 391  YTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK---- 446

Query: 463  SGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 522
              + K+K KVK+K K + K +E +  K+  +   ++   + +  +G D  +     G  +
Sbjct: 447  --QQKEKNKVKKKRKKETKGREVRFGKRSDKFC-SSESESESSESGEDDRDSLGSSGCLK 503

Query: 523  KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHT--------KTCLSPGSSEM 574
             S     D SL    +S   +  H    ++KQ+     +HT        KT  SP  SE+
Sbjct: 504  GSPLVLKDPSL-FSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEV 562

Query: 575  SLQPDLVRYDNT-ESEFLPESSSVKSCKH-KEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
            S   D  R   T ES++  E SSV+S K  +++ +H+K   L            E  SP 
Sbjct: 563  SSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASL-----------SEKKSPF 611

Query: 633  FENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHK----KEIEGEKEKYKTKDSAKELQRS 688
              +++  + K+DKEGK +KKHK KHK + KEK +    +E++ +   Y+ +DS ++  ++
Sbjct: 612  LSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKA 671

Query: 689  VEFDREFWKENFFK-SDETEDLFLNMEHES-LTLEKKSKLEKNIKDDKSTKEKHVSKERN 746
            +  + +   EN  K      D F   E  S + LE+K  L K+ K  K  K+ +    R+
Sbjct: 672  ILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRS 731

Query: 747  FKEERDKIKKE------SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLH 800
            F+EE+D+  K        EKS +EEK++  KEER+    D+ S+                
Sbjct: 732  FREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN----------D 781

Query: 801  LVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHE-HKSEKDK 857
            L E +I  EK EK  KE KEK +K    +E     E   +  F + +  K      ++D+
Sbjct: 782  LKEDKISKEK-EKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDR 840

Query: 858  --LDLSECVDKIKEKDKLYSHHTE--------------KCHKEG--EKSKNTAAIKKTDD 899
               DLS+     K +D   S  T+              +  KE   E+ +++ A +K D 
Sbjct: 841  WFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDY 900

Query: 900  RE-----KSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK------ 948
            RE     K R+ +D+  +K K + E+H  +S   +L EK  K+ +++E  +  K      
Sbjct: 901  REPFFRKKDRDYLDKNSEKRKEQTEKH--KSVPGYLSEKDKKRRESAEAGRDRKDALESC 958

Query: 949  -------GKNKEKDRE-----------LDKKEKSRDKESINITNSKHIQEEKKSSIVDGN 990
                    K +E  RE            DK +    K           +E++K    D  
Sbjct: 959  KERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKE 1018

Query: 991  KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDR-YKE----RDKH-----KDKIQIN 1040
            + +  KP   KEK+ D+        EK +KDK+ D+ +KE    ++KH     KDK +  
Sbjct: 1019 RKEKTKPERYKEKSSDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKA 1078

Query: 1041 SLLKLKSEADKPKP-----KSSPASKDTRPKEKRLVNDDLMQTSFE-----------RML 1084
            SL + K + +K  P       S    D + KEK     D+     E           +M 
Sbjct: 1079 SLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138

Query: 1085 SLKDL-------EIEQW--------HKK-----HKEKIKQKE-KERLRNRNCLELKIKDK 1123
               DL       E E+         H+K     H E+ K KE ++R ++R   +     K
Sbjct: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198

Query: 1124 EKTKHTPTESKNKELT---RSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSF 1180
            EK      E K+KE T   + +    +   T++K+ K  +  +++           K   
Sbjct: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258

Query: 1181 VSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSD----FMLE 1236
             SD        S+  K   S+ +   +     E++ H          EY  D        
Sbjct: 1259 KSDKE-----HSKERKSSRSADAEKSLLEKLEEEALH----------EYREDSNDKISEV 1303

Query: 1237 SSESQMSFSQSP----FLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSS 1289
            SS+S     Q P    FL ++ +    + +    A LPE++K    +R S+S  + S
Sbjct: 1304 SSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360



 Score =  452 bits (1162), Expect = e-126
 Identities = 231/337 (68%), Positives = 275/337 (81%), Gaps = 10/337 (2%)

Query: 1730 QIPQRMTRNKANTMANQSKQILASCTLLSEKD---SESSSPRGRIRLTEDDDPQIHHPRK 1786
            +IPQRMTRN+A  +ANQSKQ        SEK+   + +   R + R +EDDD Q  HPRK
Sbjct: 2331 EIPQRMTRNRAQMLANQSKQGPPP----SEKECAPTPAPVTRAKARGSEDDDAQAQHPRK 2386

Query: 1787 RKVSRVPQPVQ--VSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRK 1844
            R+  R  Q +Q  ++ S  Q +E  QQ+LAAIVD++KLD I+PY S+RANPYFEYL IRK
Sbjct: 2387 RRFQRSTQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRANPYFEYLQIRK 2446

Query: 1845 KIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFR 1904
            KIEEKRK+LC + PQAPQ Y EYVT+ GSYLLDG PLSK+ IP I PPPSL++PLKELFR
Sbjct: 2447 KIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEPLKELFR 2506

Query: 1905 QQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNV 1964
            QQE VR KLRLQHSIEREKLIVS EQE+LRVH RAART+ANQ +PFSACT+LLD+EVYN+
Sbjct: 2507 QQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTMLLDSEVYNM 2566

Query: 1965 PLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQ 2024
            PL+SQ D++K SVRDRFNARQF+SWLQDVDDK+D++KTCLLMRQQHEAAALNAVQR+EWQ
Sbjct: 2567 PLESQGDENK-SVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAALNAVQRMEWQ 2625

Query: 2025 LKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTP 2061
            LK+QELDPA +KS+ + E+  FYVP+VDVNDDF L P
Sbjct: 2626 LKVQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLP 2662



 Score =  181 bits (460), Expect = 5e-45
 Identities = 258/1123 (22%), Positives = 454/1123 (40%), Gaps = 184/1123 (16%)

Query: 289  DVAETEELELLLKREVPLSDDDESYTDSEEAQSVN-PSSVDENIDSET-----EKDSLIC 342
            D +   E E  LK + P  +    Y +  + +S + PS +++  D +      EK+ +  
Sbjct: 737  DRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFK 796

Query: 343  ESKQILPSKTPL--PSALDEY----EFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKT 396
            E K+ L  +      SA DEY    +F +++D + +        L  +QR     +   +
Sbjct: 797  EDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFS--------LSDDQRDRWFSDLSDS 848

Query: 397  HLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS------------ 444
                K E ++       +  K   V     E+  E++ + ++ S +              
Sbjct: 849  SFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKK 908

Query: 445  ----VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKEN--QELKQEKEGKENT 498
                +   +     QT+K   V G   +K K +R+     +++++  +  K+ ++G+   
Sbjct: 909  DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968

Query: 499  RITNLTV--NTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 556
               +       G +   K + +G+F K   P +       H +  K  K       K+ T
Sbjct: 969  EEAHREELKECGCESGFKDKSDGDFGKGLEPWER-----HHPAREKEKKDGPDKERKEKT 1023

Query: 557  PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 616
              ++   K+     S +   +  ++     + EF       K  K K K  H KD   + 
Sbjct: 1024 KPERYKEKS-----SDKDKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK- 1077

Query: 617  GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 676
                  K K E   P   + D + KK DK+GK    +       E E  +    G   K 
Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKM 1137

Query: 677  KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
                 A +L R+         +   + +E  + + +  H   + ++  + +K+ +     
Sbjct: 1138 ---GEASDLPRT---------DGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRR 1185

Query: 737  KEKHVS------KERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGM 790
            K++  +      KE+ F++ ++K  KES + +++ K      +R ++ + +D +      
Sbjct: 1186 KDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRK------DRASVDSTQDKKNKQKLP 1239

Query: 791  SAIEESIGLHLVEKEIDIEKQEKHIKE-SKEKPEKRSQIKEKDI-EKMERKTFEKEKKIK 848
               E+    H  E +   + +EK  KE SKE+   RS   EK + EK+E +   + ++  
Sbjct: 1240 EKAEKK---HAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDS 1296

Query: 849  HEHKSE----------------------------KDKLDLSECV-DKIKEKDK-LYSHHT 878
            ++  SE                             DK   S C+ +K+KEK++  +S  +
Sbjct: 1297 NDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSS 1356

Query: 879  EKCHKEGEKSKNTAAIKKT---DDREKSREKMDRKHDKE-------------KPEKERHL 922
             K   + E++K   A KK    D +E    K   +++K+             K + E  L
Sbjct: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416

Query: 923  AESKEKHLMEKKNKQSDNSEYSKS----------------EKGKNKEKDREL--DKKEKS 964
             ++ E    EKK+K     E SK                 ++ K +EK RE   D+KE+ 
Sbjct: 1417 DKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERH 1476

Query: 965  RDKESINITNS------KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
            RD+ +  +         +H ++E+K +  D    +   P  LK+K++DE  +  D K K+
Sbjct: 1477 RDRHADGLLRHHRDELLRHHRDEQKPATRD----KDSPPRVLKDKSRDEGPRLGDAKLKE 1532

Query: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
            K     ++ K              +K+ +  DK  P   P  KD RP+EK L + DLM T
Sbjct: 1533 KFKDGAEKEK-----------GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMT 1581

Query: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKEL 1138
            SFERMLS KDLEIE+ HK+HKE++KQ EK R R+ +      K KEK K      K    
Sbjct: 1582 SFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD-----PKLKEKAKPADDGRKKGLD 1636

Query: 1139 TRSKSSEVTDAYTKEKQPKD------AVSNR---SQSVDTKNVMTLGKSSFVSDNSLNRS 1189
              +K     D   K+K+ K+      A  N+   +   D+K+ +       V    L  S
Sbjct: 1637 IPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEV----LPAS 1692

Query: 1190 PRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPF 1249
            PR +  +P       S++S  S E+  HT   TP    +  +D + + ++SQ S      
Sbjct: 1693 PRPDQSRPTGVPTPTSVLSCPSYEEVMHTP-RTPSCSADDYADLVFDCADSQHSTPVPTA 1751

Query: 1250 LSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVE 1292
             + A SP+  +R   + + L E      A  LST+  RS SV+
Sbjct: 1752 PTSACSPSFFDRFSVASSGLSENASQAPARPLSTNLYRSVSVD 1794


>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
          Length = 777

 Score =  133 bits (334), Expect = 2e-30
 Identities = 70/153 (45%), Positives = 99/153 (64%), Gaps = 1/153 (0%)

Query: 149 SPDSTPNHPSQTTPAQ-KKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISL 207
           SP + P+  S ++  +   +PS+     +   KRN RGET LH+A+I+GD+  V+ L+  
Sbjct: 391 SPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQN 450

Query: 208 GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIV 267
           G++ NVKD AGWTPLHEACN G+  V ++L+   A VNT G  +D+PLHD+A +GH DIV
Sbjct: 451 GSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIV 510

Query: 268 KLLLRHGGNPFQANKHGERPVDVAETEELELLL 300
           KLLL +G +    N  G RPVD  + E ++ LL
Sbjct: 511 KLLLSYGASRNAVNIFGLRPVDYTDDESMKSLL 543


>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score =  128 bits (322), Expect = 5e-29
 Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)

Query: 147  DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
            DN      N    +   +K+       +  ++NKRN RGE+ LH+A  RG++  VK LI 
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176

Query: 207  LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
             GA+VN+ D AGWTPLHEA N G  D+   L+ AGA VN + +D   PLHD+ ++ H   
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236

Query: 267  VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
             ++LL++G NP Q ++  +  +D A+ E+++ LL+          SY   E         
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279

Query: 327  VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
                  +  E D+++ E    + SK       D+            K ID   +  +E+ 
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322

Query: 387  KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
            +E+    +      +  +EK  Y   F+ +  +         E   E+ L+ KKI  +  
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375

Query: 445  VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
               +    D+   K+Y VS E  + G ++ +L N    +++  +  +K+ K + +I N  
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433

Query: 505  VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
              T L C    K             ++ TSL +L H  +G     S  + E Q    T  
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493

Query: 559  KQEHTKTCLS 568
              ++T  CL+
Sbjct: 1494 YSQNTNICLN 1503



 Score =  104 bits (260), Expect = 8e-22
 Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)

Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
           +K    S  ++K KVNK        RN  GE  ++ AA+  D   V   I  G NVN   
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519

Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
           +AGWT LHEA   G+Y  A  L+  GADVN +GL   TPLHD+  +GH  + +LLL +G 
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579

Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
           +P   N  G+  +D A+   ++ LL+R +P     +    S +  S++P  +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630


>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score =  128 bits (322), Expect = 5e-29
 Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)

Query: 147  DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
            DN      N    +   +K+       +  ++NKRN RGE+ LH+A  RG++  VK LI 
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176

Query: 207  LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
             GA+VN+ D AGWTPLHEA N G  D+   L+ AGA VN + +D   PLHD+ ++ H   
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236

Query: 267  VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
             ++LL++G NP Q ++  +  +D A+ E+++ LL+          SY   E         
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279

Query: 327  VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
                  +  E D+++ E    + SK       D+            K ID   +  +E+ 
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322

Query: 387  KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
            +E+    +      +  +EK  Y   F+ +  +         E   E+ L+ KKI  +  
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375

Query: 445  VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
               +    D+   K+Y VS E  + G ++ +L N    +++  +  +K+ K + +I N  
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433

Query: 505  VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
              T L C    K             ++ TSL +L H  +G     S  + E Q    T  
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493

Query: 559  KQEHTKTCLS 568
              ++T  CL+
Sbjct: 1494 YSQNTNICLN 1503



 Score =  104 bits (260), Expect = 8e-22
 Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)

Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
           +K    S  ++K KVNK        RN  GE  ++ AA+  D   V   I  G NVN   
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519

Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
           +AGWT LHEA   G+Y  A  L+  GADVN +GL   TPLHD+  +GH  + +LLL +G 
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579

Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
           +P   N  G+  +D A+   ++ LL+R +P     +    S +  S++P  +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630


>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score =  128 bits (322), Expect = 5e-29
 Identities = 114/430 (26%), Positives = 189/430 (43%), Gaps = 51/430 (11%)

Query: 147  DNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
            DN      N    +   +K+       +  ++NKRN RGE+ LH+A  RG++  VK LI 
Sbjct: 1117 DNMSKELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIE 1176

Query: 207  LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
             GA+VN+ D AGWTPLHEA N G  D+   L+ AGA VN + +D   PLHD+ ++ H   
Sbjct: 1177 SGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKA 1236

Query: 267  VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSS 326
             ++LL++G NP Q ++  +  +D A+ E+++ LL+          SY   E         
Sbjct: 1237 AEILLQNGANPNQKDQKQKSALDEADDEKMKELLR----------SYGAIETV------- 1279

Query: 327  VDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQR 386
                  +  E D+++ E    + SK       D+            K ID   +  +E+ 
Sbjct: 1280 ------NRDESDAIVNEKIPAVRSKRHKQCFCDD-----------GKTIDSSSLSHQERS 1322

Query: 387  KENEPEAEKTHLFAK--QEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCS 444
            +E+    +      +  +EK  Y   F+ +  +         E   E+ L+ KKI  +  
Sbjct: 1323 RESLSVHQTLSAILQDIEEKQEYLLEFEIRNPE-------DAEQYIEKMLKIKKIMDNVL 1375

Query: 445  VIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLT 504
               +    D+   K+Y VS E  + G ++ +L N    +++  +  +K+ K + +I N  
Sbjct: 1376 AKQKAERDDL--AKKYRVSIESFKHGALREQLANLAARQKSLLVVAKKQKKISLKIQNCR 1433

Query: 505  VNTGLDC--SEKTREEGNFRKSFSPKDDTSL-HLFHISTGKSPKHSCGLSEKQ---STPL 558
              T L C    K             ++ TSL +L H  +G     S  + E Q    T  
Sbjct: 1434 NVTSLPCLSLRKLPPRSEISSEKDSQELTSLENLEHPQSGSLSPVSGSMQETQLSLETWN 1493

Query: 559  KQEHTKTCLS 568
              ++T  CL+
Sbjct: 1494 YSQNTNICLN 1503



 Score =  104 bits (260), Expect = 8e-22
 Identities = 62/174 (35%), Positives = 92/174 (52%), Gaps = 11/174 (6%)

Query: 164 QKKTPSSSSRQKDKVNK--------RNERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
           +K    S  ++K KVNK        RN  GE  ++ AA+  D   V   I  G NVN   
Sbjct: 460 RKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPS 519

Query: 216 FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
           +AGWT LHEA   G+Y  A  L+  GADVN +GL   TPLHD+  +GH  + +LLL +G 
Sbjct: 520 YAGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGA 579

Query: 276 NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDE 329
           +P   N  G+  +D A+   ++ LL+R +P     +    S +  S++P  +++
Sbjct: 580 DPLFRNDDGKCALDEAKDLCMKRLLERYIP---KHQKCLTSAQRSSIDPLDIED 630


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 899

 Score =  111 bits (277), Expect = 8e-24
 Identities = 116/591 (19%), Positives = 273/591 (46%), Gaps = 52/591 (8%)

Query: 603  KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTL---------KKMDKEGKTLKKH 653
            K+ ++ Q+   L   EKS  ++  ++     E +   L         ++M ++ + L++ 
Sbjct: 225  KKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 284

Query: 654  KLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNM 713
            + K +++E++  ++E    +++ K ++  +++ R  +  RE  KE              +
Sbjct: 285  EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE--------------L 330

Query: 714  EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE 773
              +   L ++ +L +  +  +  +EK   +E   +E+ +K+ ++ E+ + +EK    +E+
Sbjct: 331  REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390

Query: 774  R----ENIPTDKDSEFTSLGMSAIEESIGLHLVEK---EIDIEKQEKHIKESKEKPEKRS 826
            +    E    ++D           E+      VEK   E  +++QEK  ++ +EK ++  
Sbjct: 391  KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450

Query: 827  QIKEKD---------IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH 877
            +I+E++         + + E K  ++E+ +  + + E  +  L E  +K+ E++K+    
Sbjct: 451  RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM-QEQ 509

Query: 878  TEKCHKEGEKSKNTAAI----KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEK 933
             EK  ++ EK ++   +    KK   +EK RE+ D+  ++E+  +++      ++  MEK
Sbjct: 510  EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569

Query: 934  KNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
            K ++ +   + + EK + +E+ RE +KK +  ++           QEEK     +    Q
Sbjct: 570  KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629

Query: 994  HEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS----EA 1049
             EK    +EK  ++  K  + +EK  + + +   KE+    +K+Q    ++ +     E 
Sbjct: 630  EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689

Query: 1050 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK--KHKEKIKQKEK 1107
            +K + K+    K T  +EK +  ++ M+   ++M   +++  EQ  K  + +EK++++E+
Sbjct: 690  EKMEKKTQEQEKKTWDQEK-MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748

Query: 1108 ERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1158
            E       +  + +   + +  P E K K     K  E    + +E++ +D
Sbjct: 749  EMWEQEEKMWEQEEKMWEQQRLP-EQKEKLWEHEKMQEQEKIWEQEEKMRD 798



 Score =  100 bits (250), Expect = 1e-20
 Identities = 105/523 (20%), Positives = 253/523 (48%), Gaps = 56/523 (10%)

Query: 641  KKMDKEGKTLKKHKLKHKEREK-----EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREF 695
            ++M ++ + L++ + + +E+EK     EK ++E + ++++ KT+D  +++Q     + E 
Sbjct: 397  ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ-----EEER 451

Query: 696  WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI--KDDKSTKEKHVSKERNFKEERDK 753
             +E   K  E E+     E      EK  K E+N+  +++K  +++ + +++    E++K
Sbjct: 452  IREREKKMREEEETMREQE------EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505

Query: 754  IKKESEKSF-REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 812
            ++++ EK + +EEKI+D +E                 M   E+ +      ++  + +QE
Sbjct: 506  MQEQEEKIWEQEEKIRDQEE-----------------MWGQEKKMW-----RQEKMREQE 543

Query: 813  KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 872
              + E +EK   + Q      E+ME+KT E+EKK   + +  +++  + E   K++E+++
Sbjct: 544  DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603

Query: 873  LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 932
            +     EK  ++ EK +     K  +  EK +E+ ++  ++E+   E+     +++ L E
Sbjct: 604  MMREQEEKMQEQEEKMQEQEE-KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662

Query: 933  KKNKQSDNSEYSKSEK-GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 991
            +K K  ++ +  + EK  + +EK  E +K EK   ++     + + ++EE+  S+ +  K
Sbjct: 663  QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE--SMREREK 720

Query: 992  AQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
               E+   ++E  ++E ++  + K ++++++  ++ ++  + ++K+     L  + E   
Sbjct: 721  KMREEEEMMRE--QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778

Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERML----SLKDLEIEQWHKKHK-----EKI 1102
               K     K    +EK    ++ M+   E+M      ++  E + W ++ K     EK+
Sbjct: 779  EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838

Query: 1103 KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
              +E++       +E K++ +E+      E    +  + +  E
Sbjct: 839  WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 134/674 (19%), Positives = 285/674 (42%), Gaps = 99/674 (14%)

Query: 358  LDEYEFKDDDDEEINKMIDDRHILRKEQR--KENEPEAEKTHLFAKQEKAFYPKSFKSKK 415
            L E E K  + EE  KM      LR++++  +E E E  +     +QE+    +  K  +
Sbjct: 302  LREQEGKMREQEE--KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359

Query: 416  QKPSRVLYSSTESSDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVK 473
            Q+             EE L  Q K++              M+ ++E +   + + + K +
Sbjct: 360  QEEKMREQEEKMWRQEERLWEQEKQM--------REQEQKMRDQEERMWEQDERLREKEE 411

Query: 474  RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR---KSFSPKDD 530
            R  + +   ++ +++++EK+ +E  + T        D  EK +EE   R   K    +++
Sbjct: 412  RMREQEKMWEQVEKMREEKKMQEQEKKTR-------DQEEKMQEEERIREREKKMREEEE 464

Query: 531  TSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEF 590
            T          K  K    + E++    +Q+           +  +Q    +    E + 
Sbjct: 465  TMRE----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520

Query: 591  LPESS---SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
              +       K    +EK + Q+D   E  EK    ++D++     +      K  ++E 
Sbjct: 521  RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK----MRDQEQKMWDQEERMEKKTQEQEK 576

Query: 648  KTL-KKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 706
            KT  ++ K++ +ER +E+ KK  E E+   + ++  +E +  ++   E   E   K  E 
Sbjct: 577  KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636

Query: 707  EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 766
            E+     E +    E+K   ++ + + K    +H   +     E++K++++ EK + +EK
Sbjct: 637  EEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ-----EQEKMQEQEEKIWEQEK 691

Query: 767  IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PE 823
            ++   +E+E    D++           EES+     E+E  + ++E+ ++E +EK    E
Sbjct: 692  MEKKTQEQEKKTWDQEK-------MREEESMR----EREKKMREEEEMMREQEEKMQEQE 740

Query: 824  KRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
            ++ Q +E+++ + E K +E+E+K+  + +  + K  L E  +K++E++K++    EK   
Sbjct: 741  EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH-EKMQEQEKIWEQE-EKMRD 798

Query: 884  EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 943
            + EK +               EKM  + +K + ++E+   + ++    E+K    +   +
Sbjct: 799  QEEKMRG------------QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846

Query: 944  SKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK 1003
             + EK + K + +E    EK R++E                          EK    +EK
Sbjct: 847  GQEEKMEEKMQGQE----EKMREQE--------------------------EKMRGQEEK 876

Query: 1004 TKDEPLKTPDGKEK 1017
             +++  K    +EK
Sbjct: 877  MREQEEKMRGQEEK 890



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 96/477 (20%), Positives = 216/477 (45%), Gaps = 76/477 (15%)

Query: 664  KHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEH 715
            +HKK     +E  K +D+   EL R+   + E  K+N            E  ++ LN++ 
Sbjct: 191  RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250

Query: 716  ESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERE 775
                LE+   L   ++ + + +E+   +E   +E+  KI+K+ EK +R+E+         
Sbjct: 251  LKRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--------- 300

Query: 776  NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEK 835
                                     L E+E  + +QE    E   + EKR + +EK++ +
Sbjct: 301  ------------------------RLREQEGKMREQE----EKMWRQEKRLREQEKELRE 332

Query: 836  MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIK 895
             E++  E+++  + E + ++ +  + E  +K++E+++      E+   E EK       K
Sbjct: 333  QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW-EQEKQMREQEQK 391

Query: 896  KTDDREKSREKMDRKHDKEKPEKERH-LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
              D  E+  E+ +R  +KE+  +E+  + E  EK   EKK ++ +     + EK + +E+
Sbjct: 392  MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451

Query: 955  DRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPL 1009
             RE +KK     E  R++E       +++ E+++         + ++ L  +EK +++  
Sbjct: 452  IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511

Query: 1010 KTPDGKEKDK------------------KDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
            K  + +EK +                  ++++   +++ +K +D+ Q     K+  + ++
Sbjct: 512  KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQEER 566

Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
             + K+    K T  +E+++  ++ M+   ++M   +++  EQ  K  +++ K +E+E
Sbjct: 567  MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 123/598 (20%), Positives = 244/598 (40%), Gaps = 68/598 (11%)

Query: 279 QANKHGERPVDVAETEEL-----ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
           Q  K  E+   + E EE      E L ++E  + + ++   D EE        + E  + 
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412

Query: 334 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ--RKENEP 391
             E++ +  + +++   K      + E E K  D EE  KM ++  I  +E+  R+E E 
Sbjct: 413 MREQEKMWEQVEKMREEKK-----MQEQEKKTRDQEE--KMQEEERIREREKKMREEEET 465

Query: 392 EAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSN 451
             E+     KQE+  + +  K  +Q+            ++   Q +KI      I +   
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525

Query: 452 SDMQTKKEYVVSGEHKQKGKV---KRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG 508
              Q KK +      +Q+ ++   + K+++Q +   +QE + EK+ +E  + T       
Sbjct: 526 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT------- 578

Query: 509 LDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLS 568
            D  EK REE   R+                  K  +    +  +Q   ++++  K    
Sbjct: 579 WDQEEKMREEERMRER----------------EKKMREEEEMMREQEEKMQEQEEK---- 618

Query: 569 PGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDED 628
                M  Q + +     E E   +    K  + +EK   Q++   E       K K  +
Sbjct: 619 -----MQEQEEKM----WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669

Query: 629 HSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 688
           H    E      K  ++E K  ++ K++ K +E+EK       ++EK + ++S +E ++ 
Sbjct: 670 HEKMQEQE----KMQEQEEKIWEQEKMEKKTQEQEKKT----WDQEKMREEESMREREKK 721

Query: 689 VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKK--SKLEKNIKDDKSTKEKHVSKERN 746
           +  + E  +E   K  E E+     E E    E+K   + EK  +  +  ++K    E  
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781

Query: 747 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 806
             +E++KI ++ EK   +E+    +EE+     +K            E+  G     +E 
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG-----QEE 836

Query: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 864
            +  QE+ +   +EK E++ Q +E+ + + E K   +E+K++ + +  + + +   CV
Sbjct: 837 KMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCV 894



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 64/332 (19%), Positives = 153/332 (46%), Gaps = 51/332 (15%)

Query: 809  EKQEKHIKE-SKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHKSEKDKLDLSECVD 865
            +K +++I+E +KE+     ++    I  E++++K  E ++K+    +SEK ++ L+    
Sbjct: 193  KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLN---- 247

Query: 866  KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAES 925
             +KE  +          +    +      ++ ++  +  +K+ ++ +K   ++ER     
Sbjct: 248  -VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER----- 301

Query: 926  KEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSS 985
                L E++ K  +  E    ++ + +E+++EL ++EK        +   K ++E+++  
Sbjct: 302  ----LREQEGKMREQEEKMWRQEKRLREQEKELREQEK-------ELREQKELREQEEQM 350

Query: 986  IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKL 1045
                 + Q EK    +EK +++             ++ + R +ER   ++K       K+
Sbjct: 351  -----QEQEEKMWEQEEKMREQ-------------EEKMWRQEERLWEQEKQMREQEQKM 392

Query: 1046 KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQK 1105
            + + ++   +     +  R KE+R+   + M    E+M   K ++ EQ  K   ++ K +
Sbjct: 393  RDQEERMWEQ----DERLREKEERMREQEKMWEQVEKMREEKKMQ-EQEKKTRDQEEKMQ 447

Query: 1106 EKERLRNRNCLELKIKDKEKTKHTPTESKNKE 1137
            E+ER+R R   E K++++E+T     E   K+
Sbjct: 448  EEERIRER---EKKMREEEETMREQEEKMQKQ 476


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 668

 Score =  110 bits (276), Expect = 1e-23
 Identities = 105/488 (21%), Positives = 245/488 (50%), Gaps = 48/488 (9%)

Query: 649  TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
            T+   +LK K  + ++  + +E EK + +   + KEL+R +E  +    +   +++    
Sbjct: 213  TITDEELKEKNAKLQEKLQLVESEKSEIQL--NVKELKRKLERAKLLLPQQQLQAEADH- 269

Query: 709  LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEK-SFRE 764
              L  E +S++ + ++++E+N    + ++  +EK   +E   +E  +KI+++ EK   +E
Sbjct: 270  --LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327

Query: 765  EKIKDLKEE---RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
            EKI++ +E+   +E +  +K+ +         E+   +  +E E+  EK+EK I+E +EK
Sbjct: 328  EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE-EMMWEKEEK-IRELEEK 385

Query: 822  PEKRSQIKEKDIEKMER-KTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEK 880
              ++ +I+E++ ++ E  K  E+EK+ + E K  + +  + E  +KI+E++K      EK
Sbjct: 386  MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445

Query: 881  CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
             H++                EK RE+  R+  +E   +E  + E +E  +  +K K  + 
Sbjct: 446  IHEQ----------------EKIREEEKRQEQEEMWRQEEKIREQEE--IWRQKEKMHEQ 487

Query: 941  SEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSL 1000
             +  K E+   +++++  D++EK R++E       + I+E+++       + Q EK    
Sbjct: 488  EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI-----REQEEKIREQ 542

Query: 1001 KEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPAS 1060
            +E  +++  K  + +EK ++ + + R +E+ + +++       K++ + +K + +     
Sbjct: 543  EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE-------KIREQKEKIREQEE--- 592

Query: 1061 KDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI 1120
            K    +EK    +++MQ   E+M   ++   EQ  K  +++ K + +E       + L+ 
Sbjct: 593  KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652

Query: 1121 KDKEKTKH 1128
            ++++  +H
Sbjct: 653  QEEKMQEH 660



 Score =  105 bits (263), Expect = 4e-22
 Identities = 97/435 (22%), Positives = 212/435 (48%), Gaps = 27/435 (6%)

Query: 603  KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
            KEK+ K Q+   L   EKS  ++  ++     E +   L +       D  GK L+    
Sbjct: 220  KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279

Query: 654  KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
            KL+ +  E E   +  + ++EK ++ ++  +E +  ++   E  +E   K  E E+    
Sbjct: 280  KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339

Query: 713  MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 772
             E      E+K + ++ +  +K  K + +  E    E+ +KI++  EK   +EKI++ +E
Sbjct: 340  QEEMMWEKEEKMRRQEEMMWEKEEKMRRL--EEMMWEKEEKIRELEEKMHEQEKIREQEE 397

Query: 773  ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
            +R   E I   +  +     M   EE I     E+E  I +QEK +   +EK  ++ +I+
Sbjct: 398  KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEEKIHEQEKIR 453

Query: 830  EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
            E++  + + + + +E+KI+ + +  + K  + E  +KI+++++      EK H + EK +
Sbjct: 454  EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE-QEKIRKQEEKVWRQEEKMHDQEEKIR 512

Query: 890  NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
                 K     EK RE+ ++ +  +EK  ++  + + +E+ + E++ K  +  +  + E+
Sbjct: 513  EQEE-KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571

Query: 949  GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 1008
               +++++  ++KEK R++E       + I+E+++       + Q EK    +EK  ++ 
Sbjct: 572  KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM-----QEQEEKMWEQEEKMCEQE 626

Query: 1009 LKTPDGKEKDKKDKD 1023
             K  + +EK ++ ++
Sbjct: 627  EKMQEQEEKMRRQEE 641



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 76/360 (21%), Positives = 183/360 (50%), Gaps = 24/360 (6%)

Query: 641 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 700
           K  ++E K  ++ +   ++ EK + ++E+  EKE+ K +   + +    E  R   +  +
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEEKMRRLEEMMW 373

Query: 701 FKSDETEDLFLNMEHESLTLEKKSKL--EKNIKDDKSTKEKHVS---KERNFKEERDKIK 755
            K ++  +L   M  +    E++ K   E+ I++ +  +E+      +E   +E+ +KI+
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433

Query: 756 KESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
           ++ +K +R EEKI + ++ RE     +  E     M   EE I     ++EI  +K++ H
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKIR---EQEEIWRQKEKMH 485

Query: 815 IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKL 873
            +E   K E++   +E+ +   E K  E+E+K+ + E K  + +  + E  +KI+E++++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545

Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTDDR-----EKSREKMDRKHDKEKP--EKERHLAESK 926
                EK  ++ EK +    +++ +++     EK RE+ ++  ++E+   E+E  + E +
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE-Q 604

Query: 927 EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
           E+ + E++ K  +  E    ++ K +E++ ++ ++E+   ++ + +   +   +E +  +
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 112/534 (20%), Positives = 232/534 (43%), Gaps = 90/534 (16%)

Query: 649  TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
            T +K +L+      +   K++EGE      +D    L  S +F  E   E    +  T+ 
Sbjct: 136  TCQKTELQMALYYSQHAVKQLEGE-----ARDLISRLHDSWKFAGEL--EQALSAVATQK 188

Query: 709  LFLNMEHESLTLEKKS---KLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
               +   E LT E+ +   +L +N   D+  KEK+   +   +        ESEKS  + 
Sbjct: 189  KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ------LVESEKSEIQL 242

Query: 766  KIKDLKEEREN----IPTDK-DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE 820
             +K+LK + E     +P  +  +E   LG      S  L    +E ++  +    +E K 
Sbjct: 243  NVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM 302

Query: 821  -KPEKRSQIKEKDIEKMERKTFEKEKKIKH-EHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
             + E++ Q  E+ I++ E K  E+E+KI+  E K  + +  + E  +K++ ++++     
Sbjct: 303  WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362

Query: 879  EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
            EK  +  E           +  EK RE  ++ H++EK      + E +EK   E+K ++ 
Sbjct: 363  EKMRRLEEMM--------WEKEEKIRELEEKMHEQEK------IREQEEKRQEEEKIREQ 408

Query: 939  DNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 998
            +  +  +++  + +EK RE ++K + ++K+          QEEK           HE+  
Sbjct: 409  EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR-------QEEKI----------HEQ-- 449

Query: 999  SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSP 1058
                             EK ++++     +E  + ++KI      + + E  + K K   
Sbjct: 450  -----------------EKIREEEKRQEQEEMWRQEEKI------REQEEIWRQKEKMHE 486

Query: 1059 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK-----EKIKQKEKERLRNR 1113
              K  + +EK    ++ M    E+   +++ E + W ++ K     EKI+++E E++R +
Sbjct: 487  QEKIRKQEEKVWRQEEKMHDQEEK---IREQEEKMWRQEEKIREQEEKIREQE-EKIREQ 542

Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSV 1167
               E+  + +EK      + + +E  R +  ++ +   K ++ K+ +  + + +
Sbjct: 543  E--EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 78/392 (19%), Positives = 192/392 (48%), Gaps = 36/392 (9%)

Query: 601 KHKEKSKHQKDFHLEFGEK---SNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 657
           + +EK   Q++   E+ EK      KI++++            K  ++E K  ++ ++  
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE-----------KIREQEEKMRRQEEMMW 345

Query: 658 KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHES 717
           ++ EK + ++E+  EKE+ K +   + +    E  RE  +E   + ++  +     + E 
Sbjct: 346 EKEEKMRRQEEMMWEKEE-KMRRLEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQEEE 403

Query: 718 LTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777
              E++ + E+  K  +  +EK   +E   +E+  K+ ++ EK   +EKI++ ++ +E  
Sbjct: 404 KIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 462

Query: 778 PTDKDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEK---PEKRSQIKE 830
              +  E          +   +H  EK    E  + +QE+ + + +EK    E++   +E
Sbjct: 463 EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522

Query: 831 KDIEKMERKTFEKEKKIKHEHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
           + I + E K  E+E+KI+ + +  +++ + + E  +K++E++K+     EK  ++ EK +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM-RRQEEKIREQEEKIR 581

Query: 890 NTAAIKKTDDREKSREKMDR-KHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
                   + +EK RE+ ++    +EK  ++  + + +E+ + E++ K  +  E  + ++
Sbjct: 582 --------EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633

Query: 949 GKNKEKDRELDKKE-KSRDKESINITNSKHIQ 979
            K + ++ ++ ++E + R +E     + +H++
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 95/553 (17%), Positives = 223/553 (40%), Gaps = 107/553 (19%)

Query: 378 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 434
           R+ +  E+ KE   + ++     + EK+    + K  K+K  R   +L      ++ + L
Sbjct: 211 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270

Query: 435 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 489
             +  S S  +  +   +++     Q ++E +   E K +   ++  + + K +E +E  
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330

Query: 490 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 549
           +E+E K   +   +      +  EK R +    +    K++    L  +   K  K    
Sbjct: 331 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRLEEMMWEKEEK---- 378

Query: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
           + E +    +QE  +        E  ++    R +  E++   +   ++  + K + + +
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEK 437

Query: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
           K +  E       KI++E+            K+ ++E           ++ EK + ++EI
Sbjct: 438 KMWRQEEKIHEQEKIREEE------------KRQEQEE--------MWRQEEKIREQEEI 477

Query: 670 EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
             +KEK   ++  ++ +  V      W++                      EK    E+ 
Sbjct: 478 WRQKEKMHEQEKIRKQEEKV------WRQE---------------------EKMHDQEEK 510

Query: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
           I++    +EK   +E   +E+ +KI+++ EK   +E++   +EE+     +K  E   + 
Sbjct: 511 IREQ---EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567

Query: 790 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
                         +E  I +QE+ I+E KEK           I + E K +E+E+KI+ 
Sbjct: 568 -------------RQEEKIREQEEKIREQKEK-----------IREQEEKIWEQEEKIRE 603

Query: 850 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDR 909
           + +  ++            +++K++    + C +E +  +    +++ +++   +E   R
Sbjct: 604 QEEMMQE------------QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLR 651

Query: 910 KHDKEKPEKERHL 922
           + +++  E + HL
Sbjct: 652 QQEEKMQEHQEHL 664


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  109 bits (273), Expect = 2e-23
 Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 66/621 (10%)

Query: 455  QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEK 514
            +++KE V+  E  ++ +V  ++  + + +  +E  +E+EG E          T    +E+
Sbjct: 449  KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508

Query: 515  TREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM 574
                    KS   ++  S      +  KSP+      E+  +P + +  +   SP   E 
Sbjct: 509  AASPEKEAKSPVKEEAKSP-----AEAKSPE-----KEEAKSPAEVKSPEKAKSPAKEEA 558

Query: 575  SLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFE 634
               P+    +  E++   E  S +  K   K + +     +  EK+ + +K+E  SP   
Sbjct: 559  KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618

Query: 635  NSDCTLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR 693
             S    + K   E K+ +K K   KE  K   K +   EKE+ K+ + AK   ++     
Sbjct: 619  KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK-SPEKEEAKSPEKAKSPVKAEA--- 674

Query: 694  EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVS--KERNFKEER 751
                    KS E     +  E +S       K +  +K++  + EK  S  KE     E+
Sbjct: 675  --------KSPEKAKSPVKAEAKS-----PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721

Query: 752  DKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQ 811
             K   + E    E+    +KEE ++    K  E                   K +D++  
Sbjct: 722  AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA-----------------KTLDVKSP 764

Query: 812  EKHI--KESKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKS-EKDKLDLSECVDKI 867
            E     KE    P  +   K K   K E K+ EK K  +K + K+ EK+     E    +
Sbjct: 765  EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 868  KEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKE 927
            KE++K      ++  K+ E+ K   A  KT++++ S+++   K +  KP+ E     + E
Sbjct: 825  KEEEKPQEVKVKEPPKKAEEEK-APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 928  KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 987
            K    K   + + +E  K      KE   +++ KE ++ KE   +               
Sbjct: 884  KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK------------ 931

Query: 988  DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1047
            + + A+ ++P    EK +  P K    +EK KK ++  + + + K  DK    S    K 
Sbjct: 932  EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL--SKEPSKP 989

Query: 1048 EADKPKPKSSPASKDTRPKEK 1068
            +A+K +  SS   KD++P EK
Sbjct: 990  KAEKAEKSSSTDQKDSKPPEK 1010



 Score =  101 bits (252), Expect = 7e-21
 Identities = 147/633 (23%), Positives = 262/633 (41%), Gaps = 52/633 (8%)

Query: 348  LPSKTP-LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAF 406
            LP   P +PS     + K ++  ++ +  +   ++ +EQ +E +   E T    K+ K  
Sbjct: 422  LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481

Query: 407  YPKSFKSKKQKPSRVLYSSTESSD-EEALQNKKISTSCSVIPETSNSDMQTK----KEYV 461
              K  +  +++ +      T+S   EEA   +K + S   + E + S  + K    +E  
Sbjct: 482  EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS--PVKEEAKSPAEAKSPEKEEAK 539

Query: 462  VSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF 521
               E K   K K   K + K+    +  +++E K    + +          E+ +     
Sbjct: 540  SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS-PEKAKSPAKEEAKSPAEA 598

Query: 522  RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 581
            +     K          +  KSP     + E+  +P + +  +   SP + E +  P+  
Sbjct: 599  KSPEKAKSPVKEEAKSPAEAKSP-----VKEEAKSPAEVKSPEKAKSP-TKEEAKSPEKA 652

Query: 582  RYDNTESEFLPES--SSVKS-CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDC 638
            +    E    PE   S VK+  K  EK+K       +  EK+ + +K+E  SP    S  
Sbjct: 653  KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712

Query: 639  TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ-RSVEFDREFW 696
              + K  ++ K+  K + K  E+ K   K+E +   EK K+ + AK L  +S E      
Sbjct: 713  KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-EKAKSPEKAKTLDVKSPEAKTPAK 771

Query: 697  KENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 756
            +E    +D+  +   +   E +   +K+K    +K+D    EK + K    KEE     K
Sbjct: 772  EEARSPADKFPEKAKSPVKEEVKSPEKAK--SPLKEDAKAPEKEIPK----KEEVKSPVK 825

Query: 757  ESEKSFREEKIKD--LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
            E EK  +E K+K+   K E E  P    +E         ++S      +KE    K E+ 
Sbjct: 826  EEEKP-QEVKVKEPPKKAEEEKAPATPKTEEK-------KDSKKEEAPKKEAPKPKVEEK 877

Query: 815  IKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY 874
             + + EKP K S+++ K  E       E +KK+    K    K+++ E   K KEK    
Sbjct: 878  KEPAVEKP-KESKVEAKKEEA------EDKKKVPTPEKEAPAKVEVKEDA-KPKEK---- 925

Query: 875  SHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKK 934
               TE   KE + +K     K  + +E + EK D K +K K  +E+   E+K K   +  
Sbjct: 926  ---TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTL 982

Query: 935  NKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
            +K+    +  K+EK  + ++      ++ + DK
Sbjct: 983  SKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015



 Score =  100 bits (249), Expect = 1e-20
 Identities = 144/580 (24%), Positives = 250/580 (43%), Gaps = 60/580 (10%)

Query: 601  KHKEKSKHQKDFHLEFGEKSNAKIKDED-HSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
            + ++++K ++    E GE+  A+  +E+  SP  E +    K+     K   K   + K 
Sbjct: 473  EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532

Query: 660  REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
             EKE+ K   E  K   K K  AKE  +S    +   KE      E +    + E     
Sbjct: 533  PEKEEAKSPAE-VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK----SPEKAKSP 587

Query: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
             ++++K     K  +  K     + ++  E +  +K+E+ KS  E K      E+   PT
Sbjct: 588  AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA-KSPAEVK----SPEKAKSPT 642

Query: 780  DKDSEFTSLGMSAI-EESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
             ++++      S   EE+      +  +  E +     +S  K E +S  K K   K E 
Sbjct: 643  KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA 702

Query: 839  KTFEKEKK-IKHEHKS-EKDKLDLSE---CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 893
            K+ EK K  +K E KS EK K  + E     +K K   K  +   EK  K  EK+K T  
Sbjct: 703  KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-KSPEKAK-TLD 760

Query: 894  IK----KTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
            +K    KT  +E++R   D+  +K K P KE   +  K K  + K++ ++   E  K E+
Sbjct: 761  VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL-KEDAKAPEKEIPKKEE 819

Query: 949  GKN----KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT 1004
             K+    +EK +E+  KE  +  E      +   +E+K S   +  K +  KP  ++EK 
Sbjct: 820  VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKK 878

Query: 1005 KDEPLKTPDGKEKDKKDKDIDRYKERDKHKD-----KIQINSLLKLKSEADKPKPKSSPA 1059
            +    K  + K + KK++  D+ K     K+     +++ ++  K K+E  K +P  + A
Sbjct: 879  EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938

Query: 1060 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1119
             + ++P EK+    +   T  E+             KK +EK K             E K
Sbjct: 939  KEPSKPAEKKEAAPEKKDTKEEKA------------KKPEEKPK------------TEAK 974

Query: 1120 IKDKEKT-KHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1158
             K+ +KT    P++ K ++  +S S++  D+   EK  +D
Sbjct: 975  AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 103/480 (21%), Positives = 206/480 (42%), Gaps = 16/480 (3%)

Query: 702  KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 761
            KS+E   +    E E++ +E++++ E  + ++ + +E+  +KE   KEE    ++E+E  
Sbjct: 439  KSEEKIKVVEKSEKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497

Query: 762  FREEKIKDLKE----ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
              E K    +E    E+E     K+   +     + E+       E +   + +    +E
Sbjct: 498  EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557

Query: 818  SKEKPEKRSQIKEKDIEKMERKTFEKEKK-IKHEHKSEKDKLDLSECVDKIKEKDKLYSH 876
            +K  PE +S  KE+     E K+ EK K   K E KS  +     +    +KE+ K    
Sbjct: 558  AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK---S 614

Query: 877  HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKN 935
              E      E++K+ A +K  +  +   ++  +  +K K PEKE   +  K K  ++ + 
Sbjct: 615  PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 936  KQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
            K  + ++     + K+ EK +   K+E KS +K    +       E+ KS + +  K   
Sbjct: 675  KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734

Query: 995  EKPLSLKEKTKD-EPLKTPD-GKEKDKKDKDIDRYKERDKHK--DKIQINSLLKLKSEAD 1050
            +    +KE+ K  E  K+P+  K  D K  +     + +     DK    +   +K E  
Sbjct: 735  KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794

Query: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
             P+   SP  +D +  EK +   + +++  +     +++++++  KK +E+      +  
Sbjct: 795  SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854

Query: 1111 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1170
              ++  + +   KE  K    E K   + + K S+V +A  +E + K  V    +    K
Sbjct: 855  EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV-EAKKEEAEDKKKVPTPEKEAPAK 913



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/404 (23%), Positives = 163/404 (40%), Gaps = 28/404 (6%)

Query: 810  KQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
            K E+ IK   EK EK + I E+  E+    E  T E+EK+ K E   E++  +  E    
Sbjct: 439  KSEEKIKVV-EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497

Query: 867  IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
             +E     +       KE +      A  K+    KS EK + K   E    E+  + +K
Sbjct: 498  EEETKSPPAEEAASPEKEAKSPVKEEA--KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555

Query: 927  EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
            E+     + K  +  E     + K+ EK +   K+E     E+ +   +K   +E+  S 
Sbjct: 556  EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615

Query: 987  VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1046
             +      E+  S  E    E  K+P  +E    +K     KE  K  +K +      +K
Sbjct: 616  AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK----SPVK 671

Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKE 1106
            +EA  P+   SP   + +  EK          S E+  S    E +   +K K  +K++ 
Sbjct: 672  AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS-PEKAKSPVKEEA 730

Query: 1107 KERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEV-TDAYTKEKQPKDAVSNRSQ 1165
            K   + ++ ++ + K  EK K +P ++K  ++   KS E  T A  + + P D    +++
Sbjct: 731  KTPEKAKSPVKEEAKSPEKAK-SPEKAKTLDV---KSPEAKTPAKEEARSPADKFPEKAK 786

Query: 1166 SVDTKNVMTLGKSSF------------VSDNSLNRSPRSENEKP 1197
            S   + V +  K+              +      +SP  E EKP
Sbjct: 787  SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 101/464 (21%), Positives = 182/464 (39%), Gaps = 52/464 (11%)

Query: 764  EEKIKDL-KEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 822
            EEKIK + K E+E +  ++ +E T +     EE               +EK  KE + K 
Sbjct: 441  EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE---------------EEKEAKEEEGKE 485

Query: 823  EKRSQIKEKDIEKMERKT------FEKEKKIKHEHKSEKDKLDLSECVDK--------IK 868
            E+  + +E +  + E K+         EK+ K   K E      ++  +K        +K
Sbjct: 486  EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545

Query: 869  EKDKLYSHHTEKCHK-------EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
              +K  S   E+          E E++K+ A + K+ ++ KS  K + K   E    E+ 
Sbjct: 546  SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-KSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 922  LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE-KSRDKESINITNSKHIQE 980
             +  KE+     + K     E     + K+ EK +   K+E KS +K            E
Sbjct: 605  KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 981  EKKSSIVDGNKAQHEKPLSLKEKTKD-EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQI 1039
            + KS +    K+  +    +K + K  E  K+P  +E    +K     KE  K  +K + 
Sbjct: 665  KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK- 723

Query: 1040 NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHK 1099
                 +K EA  P+   SP  ++ +  EK             + L +K  E +   K+  
Sbjct: 724  ---SPVKEEAKTPEKAKSPVKEEAKSPEK------AKSPEKAKTLDVKSPEAKTPAKEEA 774

Query: 1100 EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
                 K  E+ ++    E+K  +K K+     ++K  E    K  EV     +E++P++ 
Sbjct: 775  RSPADKFPEKAKSPVKEEVKSPEKAKSP-LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833

Query: 1160 -VSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSR 1202
             V    +  + +      K+    D+    +P+ E  KP +  +
Sbjct: 834  KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 97/471 (20%), Positives = 170/471 (36%), Gaps = 40/471 (8%)

Query: 887  KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 946
            K K+   IK  +  EK  E +  +   E+ +    + E +EK   E++ K+ +  E  ++
Sbjct: 437  KVKSEEKIKVVEKSEK--ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494

Query: 947  EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK--AQHEKPLSLKEKT 1004
            E G+ + K    ++      +    +        E KS   +  K  A+ + P   K   
Sbjct: 495  EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554

Query: 1005 KDEPLKTPDGKEKDKKD-KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDT 1063
            K+E    P+ K  +K++ K     K  +K K   +  +  K  +EA  P+   SP  ++ 
Sbjct: 555  KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA--KSPAEAKSPEKAKSPVKEEA 612

Query: 1064 R-PKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRN----RNCLEL 1118
            + P E +    +  ++  E     K     +   K  EK K  EKE  ++    ++ ++ 
Sbjct: 613  KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 1119 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1178
            + K  EK K +P +++ K   ++KS    +A + EK  K  V   ++S +        KS
Sbjct: 673  EAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEK------AKS 724

Query: 1179 SFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESS 1238
                +       +S  ++   S         A + D       TP              +
Sbjct: 725  PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP--------------A 770

Query: 1239 ESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLII 1298
            + +       F   AKSP   E         PE+ K P               E+VK  +
Sbjct: 771  KEEARSPADKFPEKAKSPVKEE------VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 1299 SEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPE 1349
             E     EV+    P    E        +EE         P   +P PK E
Sbjct: 825  KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 77/376 (20%), Positives = 153/376 (40%), Gaps = 28/376 (7%)

Query: 822  PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKC 881
            P   + IK K            E+KIK   KSEK+ + + E  ++        +  TE+ 
Sbjct: 430  PSVSTHIKVK-----------SEEKIKVVEKSEKETVIVEEQTEE--------TQVTEEV 470

Query: 882  HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNS 941
             +E EK       K+ +  E+   +   +  K  P +E    E + K  ++++ K    +
Sbjct: 471  TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530

Query: 942  EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
            +  + E+ K+  + +  +K +    +E+ +   +K  ++E+  S      A+ + P   K
Sbjct: 531  KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS-----PAEVKSPEKAK 585

Query: 1002 EKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK 1061
               K+E  K+P   +  +K K   + + +   + K  +    K  +E   P+   SP  +
Sbjct: 586  SPAKEE-AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644

Query: 1062 DTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK 1121
            + +  EK    +     S E+  S    E +   +K K  +K + K   + ++ ++ + K
Sbjct: 645  EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS-PEKAKSPVKAEAKSPEKAKSPVKEEAK 703

Query: 1122 DKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFV 1181
              EK K +P + + K   ++KS    +A T EK  K  V   ++S +        K+  V
Sbjct: 704  SPEKAK-SPVKEEAKSPEKAKSPVKEEAKTPEK-AKSPVKEEAKSPEKAKSPEKAKTLDV 761

Query: 1182 SDNSLNRSPRSENEKP 1197
                     + E   P
Sbjct: 762  KSPEAKTPAKEEARSP 777



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 86/457 (18%), Positives = 167/457 (36%), Gaps = 53/457 (11%)

Query: 29   KSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSEN 88
            K+K  +   +K+P   +S V +E K  + +K       SP++ E +  +    P      
Sbjct: 603  KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP-EKAKSPTKEEAKSPEKAKSPEKEEAK 661

Query: 89   WGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDN 148
              E+  S  +  +E + PEK K+  +A  K                ++    ++  A+  
Sbjct: 662  SPEKAKSPVK--AEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719

Query: 149  SPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLG 208
                +P      TP + K+P     +  +  K  E+ +T                     
Sbjct: 720  EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT--------------------- 758

Query: 209  ANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD---TPLHDSASSGHRD 265
              ++VK     TP  E          K    A + V  +    +   +PL + A +  ++
Sbjct: 759  --LDVKSPEAKTPAKEEAR---SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813

Query: 266  IVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPS 325
            I K       +P    K  E+P +V   E  +   + + P +   E   DS++ ++    
Sbjct: 814  IPK--KEEVKSPV---KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868

Query: 326  SVDENIDSETE------KDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRH 379
            +    ++ + E      K+S +   K+    K  +P+   E   K +  E+  K  +   
Sbjct: 869  APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-KPKEKTE 927

Query: 380  ILRKE----QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQ 435
            + +KE    + KE    AEK    A ++K    +  K  ++KP      +    D++ L 
Sbjct: 928  VAKKEPDDAKAKEPSKPAEKKEA-APEKKDTKEEKAKKPEEKPKT---EAKAKEDDKTLS 983

Query: 436  NKKISTSCSVIPETSNSDMQTKKEYVVSGEHK-QKGK 471
             +          ++S++D +  K    + E K  KGK
Sbjct: 984  KEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 38.5 bits (88), Expect = 0.069
 Identities = 36/168 (21%), Positives = 66/168 (39%), Gaps = 27/168 (16%)

Query: 23  EKPYGRKSKD--KIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDS 80
           EKP   K K+  K A   K P   +++  K+ K++ + K++ P    P   E+++   + 
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP---KPKVEEKKEPAVEK 884

Query: 81  DPGHTSENWGERLISSYRTYS-EKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMAL 139
                 E   E      +  + EKE P K + K++A  K+ T V                
Sbjct: 885 PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV---------------- 928

Query: 140 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGET 187
                A+    D+    PS+    ++  P     +++K  K  E+ +T
Sbjct: 929 -----AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score =  104 bits (259), Expect = 1e-21
 Identities = 205/919 (22%), Positives = 352/919 (38%), Gaps = 166/919 (18%)

Query: 383  KEQRKENEPEAEKTHLFAKQEKA-FYPKSFK-SKKQKPSRVLYSSTESSDEEALQNKKIS 440
            KE+  E+  + EK+   +  E     PKS + S    P   + + T+  +   L NK + 
Sbjct: 249  KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQ 308

Query: 441  TSCSVIPETSNSDMQTKKEYVVSGEHKQ--KGKVKRKLKNQNKNKENQELKQEKEGKENT 498
               S     S    + K +    GE K+  K K ++K  +  K+++ Q++K EK+ KE  
Sbjct: 309  QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK- 367

Query: 499  RITNLTVNTGLDCSEKTREEGNFRKSFSPKDD---------------TSLHLFHISTGKS 543
             + +L + +  + ++    EG  ++ FS  D                + L  F   T + 
Sbjct: 368  EVESLKLPSEKNSNKAKTVEGT-KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426

Query: 544  PKHSCGLSEKQSTP-----LKQEHTKTCLSPGSSEMSL--------QPDLVR--YDNTES 588
               S  + E + T       KQ  TKT  S  S   +         +P L    Y +++ 
Sbjct: 427  VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486

Query: 589  EFLPESSSVKSCKHKEKSKHQKDFHLE-FGEKSNAKIK-----------------DEDHS 630
            E   E       K KE+   ++  + E   EK   K +                 +E  +
Sbjct: 487  ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546

Query: 631  PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 690
             + E     +K++ KE K L+K     K+R+K+    E   +K++   +DS + L+ S  
Sbjct: 547  KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606

Query: 691  FDREFWKENFFKSDETEDLFLNME--------HESLTL----EKKSKLEKNIKDDKST-- 736
             +    KE    S E + +    E         ESL +    + +SKLE+  K   ST  
Sbjct: 607  CE----KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662

Query: 737  ------------------------KEKHVSKERNFKEERDKIKKESE----KSFREEKIK 768
                                     E+   ++   K E+   K +SE    KS  ++++K
Sbjct: 663  IMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVK 722

Query: 769  DLKE--ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 826
              KE  ERE  P++       L +    +   +H    E ++   EK +K  +   ++  
Sbjct: 723  SSKEKPEREKTPSE-----DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQ 777

Query: 827  QIKEKDIEKMERKTFEKEKKIKHEHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
            Q K    +K ERK+     K ++E K     KD   +SE + K            E   K
Sbjct: 778  QTKLSSDDKTERKS-----KHRNERKLSVLGKDGKPVSEYIIKT----------DENVRK 822

Query: 884  EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH---LAESKEKHLMEKKNKQSDN 940
            E  K +   + +KT    KSR   D K  K+    ++H   L    E +  +K +  S N
Sbjct: 823  ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882

Query: 941  SEYS-KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 999
             + + K E+  +KEK R     E+    +S + T  K + +  ++ + +G   Q   P  
Sbjct: 883  MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQV-KVVETELQEGATKQATTPKP 941

Query: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK-LKSEADKPKPKSSP 1058
             KEK  +E     +  EK +K       K  DK  ++  +  +L+   S A   +  SS 
Sbjct: 942  DKEKNTEE-----NDSEKQRKS------KVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990

Query: 1059 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLEL 1118
             +K    KEK   + D   T  ER LS         HK    K   K+            
Sbjct: 991  RAKLPLAKEKYKSDKDSTSTRLERKLS-------DGHKSRSLKHSSKD------------ 1031

Query: 1119 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1178
             IK K++ K    + K  + +  K +    +  ++K  +    NR  S+  +  M  G+ 
Sbjct: 1032 -IKKKDENKSDDKDGKEVDSSHEK-ARGNSSLMEKKLSRRLCENRRGSLSQE--MAKGEE 1087

Query: 1179 SFVSDNSLNRSPRSENEKP 1197
               + N+L+    S  ++P
Sbjct: 1088 KLAA-NTLSTPSGSSLQRP 1105



 Score = 74.7 bits (182), Expect = 9e-13
 Identities = 111/522 (21%), Positives = 207/522 (39%), Gaps = 62/522 (11%)

Query: 816  KESKEKPEKRSQIKEKDIEKMERKTFEKEKK--------IKHEHKSEKDKLDLSECVDKI 867
            + SK+ P + +     D E+      +KEK         ++   KSE+   DL   V++I
Sbjct: 232  RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEI 290

Query: 868  KEKDKLY--------------SHHTEKCHKEGEKS--KNTAAIKKTDDREKSREKMDRKH 911
            K   K +              S    K   +GEK    N    +K + +EK+ +K D   
Sbjct: 291  KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK 350

Query: 912  DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE---KDRELDKKEKSRDKE 968
              E  +K +   ++KEK +   K     NS  +K+ +G  ++    D ++D         
Sbjct: 351  KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVS 409

Query: 969  SINITNSKHIQEEKKSSIV------DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK 1022
            S++ ++    +E+ +  +V      +G     ++  + + KTK +   + +GK K  +  
Sbjct: 410  SVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHA 469

Query: 1023 DIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK--EKRLVNDDLMQTS 1079
             + + Y     + D     ++ + +    K K +     +  R K  EKR    +  ++S
Sbjct: 470  YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS 529

Query: 1080 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI----KDKEKTKHTPTESKN 1135
              +      +++E+   K  E    + KE L+ R  LE K+    K K+ +++    SK 
Sbjct: 530  KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589

Query: 1136 KELTRSKSSEVTDAYTKEKQPKDAVSN-------RSQSVDTKNVMTLGKSSFVSDNSLNR 1188
            K+     S E     T E   K+ +S+        ++S  +K    L +S  V D + N 
Sbjct: 590  KQQYEEDSKETLK--TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647

Query: 1189 SPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPV-----EYDSDFMLESSESQMS 1243
            S + E E    +S  V M  V    D+        R  +     +     +      +  
Sbjct: 648  S-KLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706

Query: 1244 FSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSH 1285
             S++P L      +L ++E+ S  + PER K P  ++LS  H
Sbjct: 707  DSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 148/777 (19%), Positives = 299/777 (38%), Gaps = 134/777 (17%)

Query: 331  IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE-- 388
            +D    +  L  E K+    +T  P  ++  + ++ D  ++ + ++   I  +E +K+  
Sbjct: 641  VDENKNESKLEREHKR----RTSTPVIMEGVQ-EETDTRDVKRQVERSEICTEEPQKQKS 695

Query: 389  ---NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
               NE   +K        K+   K  KS K+KP R     T S D+ ++++K     C +
Sbjct: 696  TLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPER---EKTPSEDKLSVKHK-YKGDC-M 750

Query: 446  IPETSNSDMQTKKEYVVSGEHKQKGKVKRKL----KNQNKNKENQELKQEKEGKENTRIT 501
                  +++ + ++ +   E+ QK   + KL    K + K+K   E K    GK+   ++
Sbjct: 751  HKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVS 810

Query: 502  NLTVNTGLDCSEKTREEGNF--RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLK 559
               + T     E  R+E N   R+  + K          S  K  K S G  +   T  +
Sbjct: 811  EYIIKT----DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQR 866

Query: 560  QEHT----KTCLSPGSSEMSLQPD-LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL 614
            +  +    K  +   + + +L+P+ +V  +   ++ L E   V   K K + K  K    
Sbjct: 867  RSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVET 926

Query: 615  EFGE---KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLK----------HKERE 661
            E  E   K     K +    T EN     +K   E K  ++  ++          H  ++
Sbjct: 927  ELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQK 986

Query: 662  KEKHKKEIEGEKEKYKT-KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
               H+ ++   KEKYK+ KDS      S   +R+    +  +S         ++H S  +
Sbjct: 987  DSSHRAKLPLAKEKYKSDKDST-----STRLERKLSDGHKSRS---------LKHSSKDI 1032

Query: 721  EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
            +KK + + + KD K     H     N      K+ +   ++ R    +++ +  E +  +
Sbjct: 1033 KKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAAN 1092

Query: 781  KDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEKPEKRSQIKEKDI--E 834
              S  +   +   ++S  + L+ +    EID E   +++ E  +  + R+   ++DI  E
Sbjct: 1093 TLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSE 1152

Query: 835  KMERK---TFEKEK--------------------------KIKH-EHKSE-KDKLDLSEC 863
             M++K   T +K++                            KH +H+S    K+ +   
Sbjct: 1153 NMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSA 1212

Query: 864  VDKIKEKDKLYSHH--------TEKCHK-------EGEKS----KNTAAIKKTDDREKSR 904
            V K+   +K   H         +E  H+       E ++     KNTAA +     + + 
Sbjct: 1213 VSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATL 1272

Query: 905  EKMDRKHDKEK-------PEKERH----LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE 953
            E                 P +E +    +    ++ ++E     +  +++S         
Sbjct: 1273 EHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTV 1332

Query: 954  KDRELDKKEKSRD---------KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
            ++ E+ K   S++             +IT+ +HI E  +++++DG + +   PL  K
Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSK 1389



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 61/318 (19%), Positives = 138/318 (43%), Gaps = 29/318 (9%)

Query: 879  EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK-HLMEKKNKQ 937
            E+ H E       ++ +K D+ E           KE  E+ERH+ + K K H +  +++ 
Sbjct: 2726 EEIHSESYNKGEISSGRK-DNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784

Query: 938  SDNSEY--SKSEKGKNK--EKDRELDKKEKSRDKESINITNSK------HIQEEK---KS 984
             DN +   S+ E  + +  E +    K+E SRD E +  T+S+       + EEK    S
Sbjct: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844

Query: 985  SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK 1044
            S   G K +     ++K + +D+P+     + + +K       K +D  K    I ++ +
Sbjct: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904

Query: 1045 LKSEADKPKPKSSPASKDTRPKEKRLVNDD----LMQTSFER--------MLSLKDLEIE 1092
              S +     ++  ++K+T   ++R +++D     + TS  R        +    D E  
Sbjct: 2905 SPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964

Query: 1093 QWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTK 1152
            +  +K ++ +    +++    +  E + +++++     T S  +   +   ++++ +  +
Sbjct: 2965 EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024

Query: 1153 EKQ--PKDAVSNRSQSVD 1168
            +++  P  A +   Q V+
Sbjct: 3025 KREVSPPGARTRGQQRVE 3042



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 93/503 (18%), Positives = 180/503 (35%), Gaps = 91/503 (18%)

Query: 512  SEKTREEGNFRKSFSPKDDTSL------HLFHISTGKSPKHSCG-------LSEKQSTPL 558
            +EKT ++ + RKSF  + D  +      ++  I   +SP +  G       L  +   P 
Sbjct: 2619 AEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678

Query: 559  KQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGE 618
            ++E     L+P  S    +P  +     E   + ES +V                    E
Sbjct: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNV--------------------E 2718

Query: 619  KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 678
             S  +  +E HS ++   + +  + D   + +  H ++   +E E+ ++ +   K K   
Sbjct: 2719 NSGFRTNEEIHSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHY 2777

Query: 679  KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKE 738
              S  E                   D+  D+              S++E   +    T E
Sbjct: 2778 LSSEDE------------------PDDNPDVL------------DSRIETAQRQCPET-E 2806

Query: 739  KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG 798
             H +KE N ++  +  K  SE +    ++ + K+E  +  T  +           E++  
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKP---------EQNDD 2857

Query: 799  LHLVEKEIDIEKQEKHIKESKEKPEK---RSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
              +  +E   E Q   IK  + +P K    + +K KD  K +         +  E     
Sbjct: 2858 DTIKSQE---EDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI------VTVEQSPSS 2908

Query: 856  DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK 915
             KL + +  +  KE   L        + +GE+   T+  ++     K +  +    D E 
Sbjct: 2909 SKLKVMQTDESNKETANLQERSIS--NDDGEEKIVTSVRRRG---RKPKRSLTVSDDAES 2963

Query: 916  PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 975
             E ER   +S    + +KK ++SD  E  + E   +    R   + E  R K  ++ +  
Sbjct: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIK 3023

Query: 976  KHIQEEKKSSIVDGNKAQHEKPL 998
            +  +     +   G +   E P+
Sbjct: 3024 RKREVSPPGARTRGQQRVEEAPV 3046



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 58/338 (17%)

Query: 236  ILIAAGADVNTQGLDDDTPLHDSA------SSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
            +L+    +V   G   +  +H  +      SSG +D  + +  H               D
Sbjct: 2709 LLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVE-----------AD 2757

Query: 290  VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS------ETEK------ 337
              E EE E    R +P     + Y  SE+    NP  +D  I++      ETE       
Sbjct: 2758 PKEVEEEE----RHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813

Query: 338  -----DSLICESKQILPSKTPLPSALDEYEFKD--------DDDEEINKMIDDRHILRKE 384
                 + L   S +   + + +    DEY   +        +DD+ I    +D+ I+ K 
Sbjct: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873

Query: 385  QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS----RVLYSSTESSDEEALQNKKIS 440
            +R        +T L  K +         + +Q PS    +V+ +   + +   LQ + IS
Sbjct: 2874 KRGRPRKYPVETTLKMKDDSK-TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSIS 2932

Query: 441  TSC---SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN---KNKENQELKQEKEG 494
                   ++        + K+   VS + +     +++ K+ +   ++K+ QE  +E+E 
Sbjct: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992

Query: 495  KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTS 532
            +E    +  T  +    SE  R +     S   K + S
Sbjct: 2993 EEEDEPSGATTRS-TTRSEAQRSKTQLSPSIKRKREVS 3029


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 750

 Score =  103 bits (257), Expect = 2e-21
 Identities = 121/568 (21%), Positives = 261/568 (45%), Gaps = 79/568 (13%)

Query: 603  KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
            KEK+ K Q+   L   EKS  ++  ++     E +   L +       D  GK L+    
Sbjct: 220  KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279

Query: 654  KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
            KL+ +  E E   +  + ++EK ++ ++  +E +  ++   E  +E   K  E E+    
Sbjct: 280  KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339

Query: 713  MEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFK---------EERDKIKKESEK 760
             E      E+K + ++ +   K++K  +++ +  E+  K         E+ +KI++  EK
Sbjct: 340  QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 399

Query: 761  SFREEKIKDLKEER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
               +EKI++ +E+R   E I   +  +     M   EE I     E+E  I +QEK +  
Sbjct: 400  MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWR 455

Query: 818  SKEKPEKRSQIKEKDIEKMERKTFEKEKKI--------------KHEHKSEKDKLDLSEC 863
             +EK  ++ +I+E++  + + + + +E+KI              + E K  K +  +   
Sbjct: 456  QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515

Query: 864  VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLA 923
             +KI+E+++      EK  ++ EK      I++ ++  +  EKM   H++EK  +E    
Sbjct: 516  EEKIREQEEKIREQEEKMWRQEEK------IREQEEMWREEEKM---HEQEKIWEEEKRQ 566

Query: 924  ESKEK-HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK 982
            E ++K    E+K ++ +   + + EK + +E+ R+  +++  + +E I     K  ++E+
Sbjct: 567  EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626

Query: 983  KSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK--DKKDKDIDRYKERDKHKDKIQIN 1040
            K       + Q EK    +E T+++  K  + +EK  ++++K  ++ +   + ++KI+  
Sbjct: 627  KI------REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR-- 678

Query: 1041 SLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE 1100
                   E +K         K    +EK    +++MQ   E+M   ++   EQ  K  ++
Sbjct: 679  -------EQEK---------KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722

Query: 1101 KIKQKEKERLRNRNCLELKIKDKEKTKH 1128
            + K + +E       + L+ ++++  +H
Sbjct: 723  EEKMRRQEEKMWEQEVRLRQQEEKMQEH 750



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 113/575 (19%), Positives = 256/575 (44%), Gaps = 88/575 (15%)

Query: 369 EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 428
           +E+ + ++   +L  +Q+ +    AE  HL     K     S K + Q     L++    
Sbjct: 245 KELKRKLERAKLLLPQQQLQ----AEADHL----GKELQSVSAKLQAQVEENELWNRLNQ 296

Query: 429 SDEEAL--QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQ 486
             EE +  Q +KI      I E     ++ ++E +   E K + + +   + + K +  +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEK-IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 355

Query: 487 ELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKH 546
           E+  EKE                   EK R +    +    K++       +   K  K 
Sbjct: 356 EMMWEKE-------------------EKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK- 392

Query: 547 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 606
              + E +    +QE  +        E  ++    R +  E++   +   ++  + K + 
Sbjct: 393 ---IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIRE 448

Query: 607 KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK-EKH 665
           + +K +  E       KI++E+     E      +K+ ++ +  ++ +  H++ EK  K 
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ 508

Query: 666 KKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSK 725
           ++++  ++EK + ++     ++  E + + W++   K  E E+++          E+K  
Sbjct: 509 EEKVWRQEEKIREQE-----EKIREQEEKMWRQE-EKIREQEEMWRE--------EEKMH 554

Query: 726 LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEKIKDLKEERENIPTDKDSE 784
            ++ I ++    EK   +E     + +KI+++ EK +R EEKI++ +E+R+    +++ +
Sbjct: 555 EQEKIWEE----EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ----EQEEK 606

Query: 785 FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM---ERKTF 841
                M   EE I     E+E  I++QE+ I+E +EK  ++ ++ ++  EKM   E K  
Sbjct: 607 -----MWKQEEKIR----EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 657

Query: 842 EKEKKI--------KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA 893
           E+E+K+        + E K  + +  + E  +KI+E++++     EK  ++ EK      
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK------ 711

Query: 894 IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
           + + +++ + +E+  R+ +++  E+E  L + +EK
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 66/325 (20%), Positives = 144/325 (44%), Gaps = 41/325 (12%)

Query: 829  KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKS 888
            K+K    +E  T E++      +++     +L E   K++EK +L          E EKS
Sbjct: 188  KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV---------ESEKS 238

Query: 889  K---NTAAIKKTDDREK---SREKMDRKHD---KEKPEKERHL-AESKEKHLMEKKNKQS 938
            +   N   +K+  +R K    ++++  + D   KE       L A+ +E  L  + N+Q 
Sbjct: 239  EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ 298

Query: 939  DNSEYSKSEKGKN-KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKP 997
            +   + + EK +  +EK +E ++K + ++++          QEE      +  + Q E  
Sbjct: 299  EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358

Query: 998  LSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1057
               +EK + +     + +EK ++ +++   KE    + + +++   K++ + +K + +  
Sbjct: 359  WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418

Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
                  R +EKR   +  M    E++            ++ +EKI+++EK+  R     E
Sbjct: 419  -----IREQEKRQEQEAKMWRQEEKI------------REQEEKIREQEKKMWRQ----E 457

Query: 1118 LKIKDKEKTKHTPTESKNKELTRSK 1142
             KI ++EK +      + +E+ R +
Sbjct: 458  EKIHEQEKIREEEKRQEQEEMWRQE 482



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 56/320 (17%), Positives = 130/320 (40%), Gaps = 12/320 (3%)

Query: 842  EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 896
            E    I   H S K   +L + +  +  + K    + E+  KE      E  +NT   ++
Sbjct: 159  EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218

Query: 897  TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDR 956
              ++    ++  +  + EK E + ++ E K K    K        +      GK  +   
Sbjct: 219  LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-- 276

Query: 957  ELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKE 1016
             +  K +++ +E+         QEEK     +  +   EK    +EK +++  K  + +E
Sbjct: 277  -VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 335

Query: 1017 KDKKDKDIDRYKERD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDL 1075
            K ++ +++   KE   + ++++      K++ + +    K     K  R +E     ++ 
Sbjct: 336  KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEK 392

Query: 1076 MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKN 1135
            ++   E+M   + +  ++  ++ +EKI+++EK + +       + K +E+ +    + K 
Sbjct: 393  IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452

Query: 1136 KELTRSKSSEVTDAYTKEKQ 1155
                  K  E      +EK+
Sbjct: 453  MWRQEEKIHEQEKIREEEKR 472


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 828

 Score =  103 bits (257), Expect = 2e-21
 Identities = 101/461 (21%), Positives = 226/461 (49%), Gaps = 37/461 (8%)

Query: 665  HKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENF-------FKSDETEDLFLNMEHE 716
            HKK     +E  K +D+   EL R+   + E  K+N            E  ++ LN++  
Sbjct: 154  HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213

Query: 717  SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEEREN 776
               LE+   L   ++ + + +E+   +E   +E+  KI+K+ EK +R+E+   L+E+   
Sbjct: 214  KRKLERAKFLLPQVQTN-TLQEEMWRQEEELREQEKKIRKQEEKMWRQEE--RLREQEGK 270

Query: 777  IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKM 836
            +   ++       M   E+     L E+E ++ +QEK ++E K+  E+  Q++E++ EKM
Sbjct: 271  MREQEEK------MRRQEK----RLREQEKELREQEKELREQKKLREQEEQMQEQE-EKM 319

Query: 837  ---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
               E K  E+E+K+ + E +  + +  + E   K++++++      E+  ++ E+ +   
Sbjct: 320  WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379

Query: 893  AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNK-QSDNSEYSKSEKGKN 951
             + + +++ +  E++ R+ +K+  E+E  + E +EK   +++N  + +  E+ +    + 
Sbjct: 380  KMWEQEEKMQEEERI-REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438

Query: 952  KEKDRELDKKEKSRDK---ESINITNSKHI-QEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
            KEK  E +K ++  +K   +   I + + +  +EKK    +  + Q ++    +EK +D+
Sbjct: 439  KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498

Query: 1008 PLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKE 1067
              K  D +E+  +  +  R KE    + K       K++ E      K+    K T  +E
Sbjct: 499  EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE-----KKTQEQEKKTWDQE 553

Query: 1068 KRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
            +++  ++ M+   ++M   +++  EQ  K  +++ K +E+E
Sbjct: 554  EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594



 Score =  100 bits (250), Expect = 1e-20
 Identities = 116/578 (20%), Positives = 258/578 (44%), Gaps = 49/578 (8%)

Query: 603  KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK 662
            K+ ++ Q+   L   EKS  ++  ++     E +   L ++  +  TL++   + +E  +
Sbjct: 187  KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV--QTNTLQEEMWRQEEELR 244

Query: 663  EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEK 722
            E+ KK  + E++ ++ ++  +E +  +    E  +    +  E E      E E   L +
Sbjct: 245  EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE---LRE 301

Query: 723  KSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD 782
            + KL +  +  +  +EK   +E   +E+ +K+ ++ E+ + +EK      E+E    D++
Sbjct: 302  QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK---QMREQEQKMRDQE 358

Query: 783  SEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 842
                       E+   +   EK  + E++ +  +  +E+ EK+ + +E+ + + E K  +
Sbjct: 359  ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER-EKKMREEEETMREQEEKMQK 417

Query: 843  KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI----KKTD 898
            +E+ +  + + E  +  L E  +K+ E++K+     EK  ++ EK ++   +    KK  
Sbjct: 418  QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMW 476

Query: 899  DREKSREKMD-------RKHDKEKP---------EKERHLAESKEKHLMEKKNKQSDNSE 942
             +EK RE+ D       +  D+E+          E++  L E +E+  M ++ K     E
Sbjct: 477  RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER--MREQKKMWQQEE 534

Query: 943  YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKE 1002
              + EK   +++ +  D++EK R++E +     K  +EE+        + Q EK    +E
Sbjct: 535  KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM------REQEEKMQEQEE 588

Query: 1003 KTKDEPLKTPDGKEKDKKDKDIDRYKERDK-----HKDKIQINSLLKLKSEADKPKPKSS 1057
            K +++  K  + +EK  ++++   +++ +K      +DK+Q    +  + E    +    
Sbjct: 589  KMREQEEKMWEQEEK-MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE----EKMQE 643

Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
               K    +EK    ++ M+   E+M   ++   EQ  K   ++ K +E+E  + R   E
Sbjct: 644  QEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE-KMRGQEE 702

Query: 1118 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
                 +EK      +   +E  R K   + D   K ++
Sbjct: 703  KMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 92/500 (18%), Positives = 249/500 (49%), Gaps = 54/500 (10%)

Query: 644  DKEGKTLKKH-KLKHKEREKEKHKKEI-EGEKEKYKTKDSAKELQRSVEFDREFWKENFF 701
            ++EGK  ++  K++ +E+   + +KE+ E EKE  + K   ++ ++  E + + W++   
Sbjct: 266  EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325

Query: 702  KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKS 761
              ++ E ++     E    E++ ++ +  +  +  +E+   ++   +E+ ++++++ +  
Sbjct: 326  MREQEEKMW---RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382

Query: 762  FREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
             +EEK+++ +  RE     ++ E T              + E+E  ++KQE+++ E +EK
Sbjct: 383  EQEEKMQEEERIREREKKMREEEET--------------MREQEEKMQKQEENMWEQEEK 428

Query: 822  -------PEKRSQIKEKD-IEKMERKTFEKEKKIKHEHK--SEKDKL----DLSECVDKI 867
                   PE++ ++ E++ +++ E K +E+E+KI+ + +   ++ K+     + E  D++
Sbjct: 429  EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488

Query: 868  KEKDKLYSHHTEKCHKEGEKS-KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
             E+++      +K   + E+  +    +++ ++R + ++KM ++ +K + EK+    E K
Sbjct: 489  WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548

Query: 927  ----------EKHLMEKKNKQSDNSEYSKSEKGK---NKEKDRELDKKEKSRDKESINIT 973
                      E+ + E++ K  +  E  + ++ K    +EK RE ++K   ++++     
Sbjct: 549  TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE 608

Query: 974  NSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKH 1033
                 QEEK     + +K Q ++ +  ++   +E ++  + K  ++++K  ++ ++  + 
Sbjct: 609  EKMWEQEEKMWEQEEEDKMQEQEEMMWEQ---EEKMQEQEEKMWEQEEKMREQEEKMREQ 665

Query: 1034 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
            ++K+Q     K++ + +K + +     K    +EK    ++ M    E+M   ++    Q
Sbjct: 666  EEKMQ-GQEEKMREQEEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721

Query: 1094 WHKKHKEKIKQKEKERLRNR 1113
               + KE+  + +KE+++ R
Sbjct: 722  EEMREKEERIRDQKEKMQER 741



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 121/581 (20%), Positives = 260/581 (44%), Gaps = 71/581 (12%)

Query: 592  PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
            PE+++ + C   E  K     H E   +   +I+ +DH  T     C         KT  
Sbjct: 58   PETTTSEGCHSPEDEKKASHQHQEALRR---EIEAQDH--TIRILTCQ--------KTEL 104

Query: 652  KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK-----ENFFKSDET 706
            +  L + +    K +    GE     +KD A  L  S  F  E  +       + K  + 
Sbjct: 105  ETALYYSQDAARKFEDGNLGE-----SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADR 159

Query: 707  EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK-KESEKSFREE 765
                L  E ++L+LE    L +N   ++  K+K+        E ++K++  ESEKS  + 
Sbjct: 160  YIEELTKERDALSLE----LYRNTITNEELKKKNA-------ELQEKLRLAESEKSEIQL 208

Query: 766  KIKDLKEEREN----IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK 821
             +K+LK + E     +P  + +          EE     L E+E  I KQE+ +   +E+
Sbjct: 209  NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE-----LREQEKKIRKQEEKMWRQEER 263

Query: 822  ---PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
                E + + +E+ + + E++  E+EK+++ + K  +++  L E  ++++E+++      
Sbjct: 264  LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 879  EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
            EK  ++ EK      + + ++R   +EK  R+ +++  ++E  + E  E+   +++  + 
Sbjct: 324  EKMREQEEK------MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377

Query: 939  DNSEYSKSEKGKNKEKDRELDKK-----EKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
                + + EK + +E+ RE +KK     E  R++E       +++ E+++         +
Sbjct: 378  QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437

Query: 994  HEKPLSLKEKTKDEPLKTPDGKEKDK-------KDKDIDRYKERDKHKDKI--QINSLLK 1044
             ++ L  +EK +++  K  + +EK +       ++K + R ++  + +D++  Q   +  
Sbjct: 438  QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497

Query: 1045 LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQ 1104
             + +    + +     +  R KE+R+     M    E+M   K  + EQ  K   ++ K 
Sbjct: 498  QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ-EQEKKTWDQEEKM 556

Query: 1105 KEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
            +E+ER+R R   E K++++E+      E   ++  + +  E
Sbjct: 557  REEERMRER---EKKMREEEEMMREQEEKMQEQEEKMREQE 594



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 110/580 (18%), Positives = 240/580 (41%), Gaps = 83/580 (14%)

Query: 358 LDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAE---KTHLFAKQEKAFYPKSFKSK 414
           L E E K    EE  KM      LR+++ K  E E +   +     +QEK    +  + +
Sbjct: 243 LREQEKKIRKQEE--KMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300

Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
           +QK  R      +  +E+  + ++              +   ++E  +  + KQ  + ++
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEE--------KMREQEEKMWRQEERLWEQEKQMREQEQ 352

Query: 475 KLKNQNKNK-ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSL 533
           K+++Q +   E  E  +EKE +   +         +   E+ RE     K    +++T  
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER---EKKMREEEETMR 409

Query: 534 HLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPE 593
                   K  K    + E++    +Q+           +  +Q    +    E +   +
Sbjct: 410 E----QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465

Query: 594 SS---SVKSCKHKEKSKHQKDFHLEFGEKS-NAKIKDEDHSPTFENSDCTLKKMDKEGKT 649
                  K    +EK + Q+D   E  EK  + + K  D        D  L+  +KE + 
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERM 523

Query: 650 LKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL 709
            ++ K+  +E +  + KK  E EK+ +  ++  +E +R  E +++               
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-------------- 569

Query: 710 FLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 769
               E E +  E++ K+++  +  +  +EK   +E   +E+ +K+ ++ EK + +E+   
Sbjct: 570 ---REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626

Query: 770 LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
           ++E+ E                         + E+E  +++QE+ + E +EK  ++ +  
Sbjct: 627 MQEQEEM------------------------MWEQEEKMQEQEEKMWEQEEKMREQEEKM 662

Query: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK-EKDKLYSHHTEKCHKEGEKS 888
            +  EKM+    ++EK  + E K +  +  + E  +K++ +++K++          G++ 
Sbjct: 663 REQEEKMQG---QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMW----------GQEE 709

Query: 889 KNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
           K     +K   +E+ REK +R  D+++  +ER L E +E+
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQER-LPEHEER 748



 Score = 38.9 bits (89), Expect = 0.053
 Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 13/201 (6%)

Query: 297 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPL-- 354
           E + ++E  + + +E   D E+        + E  +   EK+  + E K++   +  +  
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538

Query: 355 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 414
                E E K  D EE  KM ++  +  +E++   E E     +  +QE+    +  K +
Sbjct: 539 EKKTQEQEKKTWDQEE--KMREEERMREREKKMREEEE-----MMREQEEKMQEQEEKMR 591

Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
           +Q+    ++   E   E+  + K       +  +     MQ ++E +   E K + + ++
Sbjct: 592 EQEEK--MWEQEEKMQEQ--EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647

Query: 475 KLKNQNKNKENQELKQEKEGK 495
             + + K +E +E  +E+E K
Sbjct: 648 MWEQEEKMREQEEKMREQEEK 668


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
            12A isoform a [Homo sapiens]
          Length = 1030

 Score =  103 bits (256), Expect = 2e-21
 Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)

Query: 168  PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
            P    RQK KV  + + G   L  A   GD  +V +L+  GA++N  +  G T LH+AC 
Sbjct: 26   PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82

Query: 228  VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 287
                D+ K L+  GA++N    +   PLH +AS G+ DI + L+  G +    N  G+ P
Sbjct: 83   DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142

Query: 288  VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 339
            +D+AE E +E LL+ EV     D      EE         Q +N   +++   +++   +
Sbjct: 143  LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202

Query: 340  L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 382
            L +  +K        L  A  +   KD D             +E    ++D   D  ++ 
Sbjct: 203  LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262

Query: 383  KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
            K  +   +   E    + ++ +         K+ K S ++ S+    + ++ +  K   +
Sbjct: 263  KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322

Query: 443  CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 502
              + PE + S +++ ++  V  E + K     K ++   ++E++E   E E +       
Sbjct: 323  LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370

Query: 503  LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 562
                     ++KT+       S +  + +S     ++   +P  S G +   S   K   
Sbjct: 371  ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416

Query: 563  TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 621
            T T +SP   E   + P   R    ++      + + + K  +K            EK  
Sbjct: 417  TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464

Query: 622  AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 681
            A +     SP   +S    K+ +K+ K  +   +      +     +IE EKE    +DS
Sbjct: 465  AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519

Query: 682  AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 741
            +  L+ S  + R  W+++  K+    +   +  H+S +  ++     +     +T    V
Sbjct: 520  S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576

Query: 742  SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 794
            +     ++          KI   S  +  +    +     ++   +KDS  T++ +    
Sbjct: 577  TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636

Query: 795  ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854
              +        +           ++ +  +RS +     E+ E +   + ++ +   +S 
Sbjct: 637  TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696

Query: 855  KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 914
            +        +  ++E +K          +E E  +     K+  D+EK  EK + +  +E
Sbjct: 697  Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751

Query: 915  KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 947
               K+++     E +   +    S ++  S S                            
Sbjct: 752  DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811

Query: 948  KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
            +G  KE +RE +K+E+  +KE  + +  K I+E ++      +           E  +++
Sbjct: 812  RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869

Query: 1008 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1063
               T +G  K +   D I RY E        + +SLL      S  ++ KP SS   KD 
Sbjct: 870  QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928

Query: 1064 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
                K+L       N+ L     +  + L DL+++       EK  Q++ ER  +R+ LE
Sbjct: 929  STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981

Query: 1118 LKIKDKEKTKHTPTESKNK 1136
            ++ +++   +   +E + +
Sbjct: 982  MEKRERRALERRISEMEEE 1000



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)

Query: 859  DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
            D+   ++++++K  L   H+EK  K+    ++TA +   D+ +  +   +++    +PEK
Sbjct: 275  DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329

Query: 919  ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
                 ES E+  +  E++ K+ ++S  S+ ++  + E + E DK      K   ++TN+ 
Sbjct: 330  NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383

Query: 977  HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
                   SS      A     +S  + T   P+K           KE+++KD+       
Sbjct: 384  -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438

Query: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
                        +I   KE  K KD   +         A  P+  SS  +K+     K  
Sbjct: 439  GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492

Query: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
                +  T   R+ S  D+E               EKE   NR+   L+      T+   
Sbjct: 493  RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533

Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
             +   K  + ++ S    + +  ++  D +S+   S  +   +T     + S +S  S  
Sbjct: 534  EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593

Query: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
                + +   G  S + + +    S    +DS  T VT P  P   +   S   L ++ +
Sbjct: 594  TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653

Query: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
                S +      +S     R+ +S +    R +    +R ST  +  + +++ +  I  
Sbjct: 654  GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713

Query: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
             R T    + +      E  KQ +   EE  +        +TS   +  + +S   +   
Sbjct: 714  SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766

Query: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
                 + +S +T+P+ +    S+S Y S+  N
Sbjct: 767  QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)

Query: 712  NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
            NM++       K+K    I+ +K+       ++    EE +  K ES  S  E++  D +
Sbjct: 307  NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366

Query: 772  EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
             E E   T   +  T+   S+ + +           +      +   +  P   S IK+ 
Sbjct: 367  SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414

Query: 832  DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
                 +    E+E+K   +      +L L         K   Y    E    KEG+K K+
Sbjct: 415  PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463

Query: 891  TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
            TA + ++    +    +D K +KEK  K   LA          +    + EK+N+ S + 
Sbjct: 464  TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522

Query: 942  EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
              S S                 +G    K     +++      S+        +T++  +
Sbjct: 523  RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582

Query: 979  QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
            Q+   SS     K       +  + +    L   D  EK+K                   
Sbjct: 583  QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642

Query: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
                                +ER +       + L  ++ E  + + K+ S  ++ +R  
Sbjct: 643  ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695

Query: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
             + +   DL +   +  R  S +  E E   +K KE+ ++++KE+   +   E   +D+ 
Sbjct: 696  TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754

Query: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
            K K++ T  +  +  R  S+      +    P  ++S  S S+   + +    S     +
Sbjct: 755  KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808

Query: 1185 SLNRSPRSENEKPG 1198
            + +R    ENE+ G
Sbjct: 809  AYSRGITKENEREG 822


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
            isoform a [Homo sapiens]
          Length = 1030

 Score =  103 bits (256), Expect = 2e-21
 Identities = 201/1039 (19%), Positives = 400/1039 (38%), Gaps = 134/1039 (12%)

Query: 168  PSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
            P    RQK KV  + + G   L  A   GD  +V +L+  GA++N  +  G T LH+AC 
Sbjct: 26   PPVVKRQKTKV--KFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACI 82

Query: 228  VGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP 287
                D+ K L+  GA++N    +   PLH +AS G+ DI + L+  G +    N  G+ P
Sbjct: 83   DDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP 142

Query: 288  VDVAETEELELLLKREVPLSDDDESYTDSEE--------AQSVNPSSVDENIDSETEKDS 339
            +D+AE E +E LL+ EV     D      EE         Q +N   +++   +++   +
Sbjct: 143  LDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTA 202

Query: 340  L-ICESKQILPSKTPLPSALDEYEFKDDD-------------DEEINKMID---DRHILR 382
            L +  +K        L  A  +   KD D             +E    ++D   D  ++ 
Sbjct: 203  LHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVN 262

Query: 383  KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
            K  +   +   E    + ++ +         K+ K S ++ S+    + ++ +  K   +
Sbjct: 263  KVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKET 322

Query: 443  CSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITN 502
              + PE + S +++ ++  V  E + K     K ++   ++E++E   E E +       
Sbjct: 323  LIIEPEKNASRIESLEQEKVDEEEEGK-----KDESSCSSEEDEEDDSESEAE------- 370

Query: 503  LTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEH 562
                     ++KT+       S +  + +S     ++   +P  S G +   S   K   
Sbjct: 371  ---------TDKTKP----LASVTNANTSSTQAAPVAV-TTPTVSSGQATPTSPIKKFPT 416

Query: 563  TKTCLSPGSSEMSLQ-PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSN 621
            T T +SP   E   + P   R    ++      + + + K  +K            EK  
Sbjct: 417  TATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQK------------EKDT 464

Query: 622  AKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDS 681
            A +     SP   +S    K+ +K+ K  +   +      +     +IE EKE    +DS
Sbjct: 465  AGVTRSASSPRL-SSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIE-EKE---NRDS 519

Query: 682  AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHV 741
            +  L+ S  + R  W+++  K+    +   +  H+S +  ++     +     +T    V
Sbjct: 520  S-SLRTSSSYTRRKWEDDLKKNSSVNE--GSTYHKSCSFGRRQDDLISSSVPSTTSTPTV 576

Query: 742  SKERNFKEE-------RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIE 794
            +     ++          KI   S  +  +    +     ++   +KDS  T++ +    
Sbjct: 577  TSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAP 636

Query: 795  ESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854
              +        +           ++ +  +RS +     E+ E +   + ++ +   +S 
Sbjct: 637  TVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRST 696

Query: 855  KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE 914
            +        +  ++E +K          +E E  +     K+  D+EK  EK + +  +E
Sbjct: 697  Q-----GVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSRE 751

Query: 915  KPEKERHLAESKEKHLMEKKNKQSDNSEYSKS---------------------------E 947
               K+++     E +   +    S ++  S S                            
Sbjct: 752  DEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYS 811

Query: 948  KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007
            +G  KE +RE +K+E+  +KE  + +  K I+E ++      +           E  +++
Sbjct: 812  RGITKENEREGEKREE--EKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQ 869

Query: 1008 PLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLK---SEADKPKPKSSPASKDT 1063
               T +G  K +   D I RY E        + +SLL      S  ++ KP SS   KD 
Sbjct: 870  QSDTEEGSNKKETQTDSISRY-ETSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDD 928

Query: 1064 RPKEKRLV------NDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
                K+L       N+ L     +  + L DL+++       EK  Q++ ER  +R+ LE
Sbjct: 929  STDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQ------LEKATQRQ-ERFADRSLLE 981

Query: 1118 LKIKDKEKTKHTPTESKNK 1136
            ++ +++   +   +E + +
Sbjct: 982  MEKRERRALERRISEMEEE 1000



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 110/572 (19%), Positives = 216/572 (37%), Gaps = 91/572 (15%)

Query: 859  DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
            D+   ++++++K  L   H+EK  K+    ++TA +   D+ +  +   +++    +PEK
Sbjct: 275  DILGYLEELQKKQNLL--HSEKRDKKSPLIESTANM---DNNQSQKTFKNKETLIIEPEK 329

Query: 919  ERHLAESKEKHLM--EKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
                 ES E+  +  E++ K+ ++S  S+ ++  + E + E DK      K   ++TN+ 
Sbjct: 330  NASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKT-----KPLASVTNA- 383

Query: 977  HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK-------TPDGKEKDKKDK------- 1022
                   SS      A     +S  + T   P+K           KE+++KD+       
Sbjct: 384  -----NTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRL 438

Query: 1023 ------------DIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRL 1070
                        +I   KE  K KD   +         A  P+  SS  +K+     K  
Sbjct: 439  GLRKTGSYGALAEITASKEGQKEKDTAGVT------RSASSPRLSSSLDNKEKEKDSKGT 492

Query: 1071 VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTP 1130
                +  T   R+ S  D+E               EKE   NR+   L+      T+   
Sbjct: 493  RLAYVAPTIPRRLASTSDIE---------------EKE---NRDSSSLR-TSSSYTRRKW 533

Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLG---KSSFVSDNSLN 1187
             +   K  + ++ S    + +  ++  D +S+   S  +   +T     + S +S  S  
Sbjct: 534  EDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTT 593

Query: 1188 RSPRSENEKPGLSSRSVSMI----SVASSEDSCHTTVTTPRPPVEYD---SDFMLESSES 1240
                + +   G  S + + +    S    +DS  T VT P  P   +   S   L ++ +
Sbjct: 594  TKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAAASTTTLTTTTA 653

Query: 1241 QMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISE 1300
                S +      +S     R+ +S +    R +    +R ST  +  + +++ +  I  
Sbjct: 654  GTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGR 713

Query: 1301 GRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPK-PEVFSNVPERDL 1359
             R T    + +      E  KQ +   EE  +        +TS   +  + +S   +   
Sbjct: 714  SRSTRTREQENEEKEKEEKEKQDKEKQEEKKE-------SETSREDEYKQKYSRTYDETY 766

Query: 1360 SNVSNIHSSFATSPTGA----SNSKYVSADRN 1387
                 + +S +T+P+ +    S+S Y S+  N
Sbjct: 767  QRYRPVSTSSSTTPSSSLSTMSSSLYASSQLN 798



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 100/554 (18%), Positives = 194/554 (35%), Gaps = 105/554 (18%)

Query: 712  NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
            NM++       K+K    I+ +K+       ++    EE +  K ES  S  E++  D +
Sbjct: 307  NMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSE 366

Query: 772  EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
             E E   T   +  T+   S+ + +           +      +   +  P   S IK+ 
Sbjct: 367  SEAETDKTKPLASVTNANTSSTQAA----------PVAVTTPTVSSGQATPT--SPIKKF 414

Query: 832  DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTE-KCHKEGEKSKN 890
                 +    E+E+K   +      +L L         K   Y    E    KEG+K K+
Sbjct: 415  PTTATKISPKEEERK---DESPATWRLGL--------RKTGSYGALAEITASKEGQKEKD 463

Query: 891  TAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE---------SKEKHLMEKKNKQSDNS 941
            TA + ++    +    +D K +KEK  K   LA          +    + EK+N+ S + 
Sbjct: 464  TAGVTRSASSPRLSSSLDNK-EKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSL 522

Query: 942  EYSKS----------------EKGKNKEKDRELDKKEKSRDKESI-------NITNSKHI 978
              S S                 +G    K     +++      S+        +T++  +
Sbjct: 523  RTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGL 582

Query: 979  QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKD----------------- 1021
            Q+   SS     K       +  + +    L   D  EK+K                   
Sbjct: 583  QKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAVTIPVAPTVVNAA 642

Query: 1022 --------------KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKS-SPASKDTRPK 1066
                                +ER +       + L  ++ E  + + K+ S  ++ +R  
Sbjct: 643  ASTTTLTTTTAGTVSSTTEVRERRR-------SYLTPVRDEESESQRKARSRQARQSRRS 695

Query: 1067 EKRLVNDDLMQT--SFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKE 1124
             + +   DL +   +  R  S +  E E   +K KE+ ++++KE+   +   E   +D+ 
Sbjct: 696  TQGVTLTDLQEAEKTIGRSRSTRTREQEN-EEKEKEEKEKQDKEKQEEKKESETSREDEY 754

Query: 1125 KTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDN 1184
            K K++ T  +  +  R  S+      +    P  ++S  S S+   + +    S     +
Sbjct: 755  KQKYSRTYDETYQRYRPVST------SSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITS 808

Query: 1185 SLNRSPRSENEKPG 1198
            + +R    ENE+ G
Sbjct: 809  AYSRGITKENEREG 822


>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
          Length = 1378

 Score =  103 bits (256), Expect = 2e-21
 Identities = 48/123 (39%), Positives = 76/123 (61%), Gaps = 3/123 (2%)

Query: 173 RQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYD 232
           R+  K N+RN+ GET LH A I G +++V++L+  G  +N +D+ GWTPLHEACN G+ +
Sbjct: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576

Query: 233 VAKILIAAGA---DVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
           + + L+  GA   D   QG +  TPLHD+ + GH ++ +LLL  G +     + G  P++
Sbjct: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636

Query: 290 VAE 292
             +
Sbjct: 637 TLQ 639


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  102 bits (255), Expect = 3e-21
 Identities = 62/175 (35%), Positives = 97/175 (55%), Gaps = 7/175 (4%)

Query: 141 MQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQ---KDKVNKRNERGE--TPLHMAAIR 195
           +Q    +++P  T +   +   A K     + +Q      VN R+  G   TPLH AA  
Sbjct: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694

Query: 196 GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 255
             V  V+ L+  GA+V+ KD  G  PLH AC+ G+Y+VA++L+  GA VN   L   TPL
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754

Query: 256 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLKREVPLSD 308
           H++A+ G  +I KLLL+HG +P + N+ G  P+D+ +  + ++  LL+ +  L D
Sbjct: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLD 809



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 53/120 (44%), Positives = 72/120 (60%)

Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
           R  TPLH+AA    V+ V+ L+  GA+V+ KD  G  PLH AC+ G+Y+V ++L+  GA 
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427

Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 303
           VN   L   TPLH++AS    ++  LLL HG +P   N HG+  VD+A T EL   L  E
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 53/170 (31%), Positives = 89/170 (52%), Gaps = 5/170 (2%)

Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
           + +N R+ +G   TPLH+AA   +++  + L+  GA+VN +D  G  PLH A + G+ D+
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885

Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 293
           A +LI     VN       TPLH++A  G   +  LLL HG +P   N+ G+ P+D+A  
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945

Query: 294 EELELLLKREVP---LSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSL 340
           +++  LL   +P   L    +       A  ++P+S    + + +  D+L
Sbjct: 946 DDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNL 995



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 43/109 (39%), Positives = 66/109 (60%)

Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
           R  +PLH AA  G    V+ L+ +GANV+ +D  G  PLH AC+ G+ +V  +L+  GAD
Sbjct: 215 RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD 274

Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
            N +   + TPLH++A  G  D+  +LL+HG +P   N  G+  +D+A+
Sbjct: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 4/158 (2%)

Query: 180 KRNERGETPLH--MAAIRGDVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 236
           K+ +  ET LH  +A++    KQV EL+   GANVN K+    TPLH A    + DV ++
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576

Query: 237 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
           L   GA +N       T LH +A +GH    +LLL +G +P   +  G     +   E +
Sbjct: 577 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG-NEAV 635

Query: 297 ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSE 334
           + +L    P+   D  Y   E +++ +  +V +   S+
Sbjct: 636 QQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 84/342 (24%), Positives = 131/342 (38%), Gaps = 75/342 (21%)

Query: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
           V+ R++ G  PLH A   G  + V  L+  GA+ N +D   +TPLHEA   G  DV  +L
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 238 IAAGADVNTQGLDDDTPLH--------------------DSASSGHRD------------ 265
           +  GAD N +  D  + L                     ++A SG+ +            
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361

Query: 266 ----------------------IVKLLLRHGGNPFQANKHGERPVDVA----ETEELELL 299
                                 IV+LLL+HG +    +K G  P+  A      E  ELL
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421

Query: 300 LKREVPLSDDD-ESYTDSEEAQSVNPSSVDENIDSETEKDSLI-CESKQILPSKTPLPSA 357
           LK    ++  D   +T   EA S N   V   + S     +L+ C  K  +    P P  
Sbjct: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV-DMAPTPEL 480

Query: 358 LDE--YEFKDDDDEEINKMID---DRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFK 412
            +   YEFK     +  +  D    +  L  E     +P++ +T L      + +PK   
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC-AVASLHPK--- 536

Query: 413 SKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDM 454
            +KQ    +L      ++    +NK   T   V  E +++D+
Sbjct: 537 -RKQVTELLLRKGANVNE----KNKDFMTPLHVAAERAHNDV 573



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 36/136 (26%), Positives = 65/136 (47%), Gaps = 6/136 (4%)

Query: 162 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 221
           P +K+      R+   VN++N+   TPLH+AA R     ++ L   GA +N  D  G T 
Sbjct: 535 PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594

Query: 222 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQAN 281
           LH A   G+    ++L++ G+D +   L   T    +A  G+  + ++L      P + +
Sbjct: 595 LHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSE--STPIRTS 648

Query: 282 KHGERPVDVAETEELE 297
               R ++ ++  +LE
Sbjct: 649 DVDYRLLEASKAGDLE 664



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 51/196 (26%), Positives = 76/196 (38%), Gaps = 55/196 (28%)

Query: 147 DNSPDST--PNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGE--------TPLHMAAIR- 195
           +NSP S+  P   S ++P+   +  + S +   V+     G          P    A+R 
Sbjct: 126 NNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRE 185

Query: 196 -------GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 248
                  GDV +VK L+   ANVN KD AG                              
Sbjct: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAG------------------------------ 214

Query: 249 LDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA----ETEELELLLKREV 304
               +PLH +A  G +D+V+ LL+ G N    +  G  P+  A      E + LLL +  
Sbjct: 215 -RKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA 273

Query: 305 -PLSDDDESYTDSEEA 319
            P + D+ +YT   EA
Sbjct: 274 DPNARDNWNYTPLHEA 289


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
            sapiens]
          Length = 600

 Score =  102 bits (254), Expect = 4e-21
 Identities = 89/418 (21%), Positives = 201/418 (48%), Gaps = 52/418 (12%)

Query: 644  DKEGKTLKKHKLKHKEREKEK--------HKKEIEGEKEKYKTKDSAKELQRSVEFDREF 695
            D +G   ++++ K +ER +EK         K+E   EK++++ +D  +E QR  E +RE 
Sbjct: 48   DADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE- 106

Query: 696  WKENFFKSDETEDLFLNMEHESLTLEKKSKLE---------------KNIKDDKSTKEKH 740
             ++   + D   +   N + E    E++++ E               +  +D +  +E+ 
Sbjct: 107  -RQTDRERDRQREKERNRQKER---ERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162

Query: 741  VSKERNFKEERDKIK-KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGL 799
              +ER  + ER++ K +E EK+ +E + ++ + E+EN   D+ SE    G     E    
Sbjct: 163  TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE---RGRERERER--- 216

Query: 800  HLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLD 859
               E E + E++ +  +E +++  K  + +EK  E+      E E+  + E + ++D+  
Sbjct: 217  ---ETETETERKRQTDRE-RDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272

Query: 860  LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKE 919
                 ++ ++ D+     TE+  +   K +     ++  +R + RE+ +R+ ++E+ E++
Sbjct: 273  DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER-ERERERER-ERQ 330

Query: 920  RHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHI 978
            R     +EK    K+ +Q++       + G+   +  E ++ +E+ RD++S     ++  
Sbjct: 331  RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS-----ARER 385

Query: 979  QEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDK 1036
            +E ++    D  K +  +     EK +D   +T   +E++ KD++ +R +ER + ++K
Sbjct: 386  EERERDRDRDRQKERERQ----TEKDRDGQRETEKQRERE-KDRESERGRERGREREK 438



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 81/354 (22%), Positives = 177/354 (50%), Gaps = 59/354 (16%)

Query: 641 KKMDKEG-KTLKKHKLKHKEREK---EKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 696
           ++ D+E  +  ++++ K +EREK   E+ ++E + EKE  KT+D   E  R  E +RE  
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN-KTEDRHSERGRERERERETE 219

Query: 697 KENFFK--SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKI 754
            E   K  +D   D     E E    EK+++ E+   + ++ ++K   +ER+   +RD+ 
Sbjct: 220 TETERKRQTDRERDRQRKTERER---EKQAERER-ASERETERDKERERERDRDRDRDRR 275

Query: 755 KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKH 814
           +KE E+        D K +R    T++D E                  E++ + +++ + 
Sbjct: 276 QKERERQ------TDRKRQRR---TERDRE-----------------TERKRERQRERER 309

Query: 815 IKESKEKPEK-RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL 873
            +E   K E+ R + +E++ ++   +  EKE++ K + ++E D+       ++ ++  + 
Sbjct: 310 ERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR-------ERNRQTGRE 362

Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP-EKERHLAESKEKHLME 932
                E+  +E E+ +         DR+ +RE+ +R+ D+++  +KER     K++    
Sbjct: 363 GRRQAER-ERERERER---------DRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412

Query: 933 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
           +  KQ +  +  +SE+G+ + ++RE   K+K R+++    T+ +  ++ K+S++
Sbjct: 413 ETEKQREREKDRESERGRERGRERE---KQKGRERDRERQTDRQAGRQRKRSTL 463



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 53/279 (18%), Positives = 123/279 (44%), Gaps = 40/279 (14%)

Query: 898  DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 957
            DDRE++R+K +R+  +EK + ER     +E+                + EK +++++DR 
Sbjct: 52   DDRERNRQK-ERERRREKRQTERETDRKRER----------------RREKDRHRKRDRH 94

Query: 958  LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEK 1017
               +E+ RD+E      +   ++ ++    +  K +  +     E+ +D   +  DG+ +
Sbjct: 95   ---RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRD---RQTDGQRE 148

Query: 1018 DKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQ 1077
             ++ +D ++ +ER   +++ Q  +    + E ++ K +     ++ + +++    D   +
Sbjct: 149  RERQRDAEKERERQTDRER-QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207

Query: 1078 TSFERMLSLK-----------DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
               ER    +           D E ++  K  +E+ KQ E+ER   R     K +++E+ 
Sbjct: 208  RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERD 267

Query: 1127 KHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1165
            +    + + KE  R      TD   + +  +D  + R +
Sbjct: 268  RDRDRDRRQKERERQ-----TDRKRQRRTERDRETERKR 301



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 71/392 (18%), Positives = 161/392 (41%), Gaps = 41/392 (10%)

Query: 467 KQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCS-----EKTREEGNF 521
           +Q+ + K + +  ++ ++ Q  K+    KE  R T      G D       E+ R+    
Sbjct: 97  RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156

Query: 522 RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLV 581
           ++     D         +  K  +      E++    +Q   +       SE   + +  
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREKNRQERRERE-RQREKENKTEDRHSERGRERERE 215

Query: 582 RYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLK 641
           R   TE+E   ++   +  + K + + +K    E   +   +   E       + D   +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275

Query: 642 KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFF 701
           + ++E +T +K + + +   + + K+E + E+E+ + ++  +E +R  E +RE       
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE------- 328

Query: 702 KSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK-----EKHVSKERNFKEERDKIKK 756
           +  ETE    + E E    E+K K +  +  +++ +      +   +ER  + ERD+   
Sbjct: 329 RQRETE---RDREKER---ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSA 382

Query: 757 ESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIK 816
              +    ++ +D ++ERE   T+KD +             G    EK+ + EK ++  +
Sbjct: 383 REREERERDRDRDRQKERER-QTEKDRD-------------GQRETEKQREREK-DRESE 427

Query: 817 ESKEKPEKRSQIK--EKDIEKMERKTFEKEKK 846
             +E+  +R + K  E+D E+   +   +++K
Sbjct: 428 RGRERGREREKQKGRERDRERQTDRQAGRQRK 459



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 52/289 (17%), Positives = 121/289 (41%), Gaps = 53/289 (18%)

Query: 909  RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
            R   +E P +       K+    +++  +    E  + ++   +E DR   K+E+ R+K+
Sbjct: 30   RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDR---KRERRREKD 86

Query: 969  SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK 1028
                                    +H K    +E+ +D   +  + + +  +++D  R K
Sbjct: 87   ------------------------RHRKRDRHRERQRD---REKERERQTDRERDRQREK 119

Query: 1029 ERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1088
            ER++ K++ +     + + E ++ + + +   ++ R +++    +   QT  ER      
Sbjct: 120  ERNRQKERER-----ETEREGERGRDRQTDGQRE-RERQRDAEKERERQTDRER------ 167

Query: 1089 LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE-VT 1147
                   ++  E+ +QKE+ER +NR   E + +++++ K   TE ++ E  R +  E  T
Sbjct: 168  -------QRQTERNRQKEREREKNRQ--ERRERERQREKENKTEDRHSERGRERERERET 218

Query: 1148 DAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
            +  T+ K+  D   +R +  + +      +    S+    R    E E+
Sbjct: 219  ETETERKRQTDRERDRQRKTEREREKQAERER-ASERETERDKERERER 266


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  102 bits (254), Expect = 4e-21
 Identities = 154/868 (17%), Positives = 381/868 (43%), Gaps = 91/868 (10%)

Query: 297  ELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQI-LPSKTPLP 355
            E L ++     + +E   + E+ QS      +E  D E  +   + E ++     K    
Sbjct: 171  EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230

Query: 356  SALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKK 415
                +  F++++++E  K      +LRKE+ K  E E ++     ++E+       +  +
Sbjct: 231  RERQDRVFQEEEEKEWRKR---ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287

Query: 416  QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRK 475
            ++             E+ L+ K+         E    + Q ++        +Q+ + +++
Sbjct: 288  RERQEEEQQQQRLRREQQLRRKQ---------EEERREQQEERREQQERREQQEERREQQ 338

Query: 476  LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHL 535
            L+ + + +  Q+L++E+E  E  R   L         E+ R E   R+    + +  L  
Sbjct: 339  LRREQEERREQQLRREQE--EERREQQLRRE-----QEEERREQQLRREQQLRREQQL-- 389

Query: 536  FHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESS 595
                     +    L  +Q    +Q+  +        ++  +  L R    E        
Sbjct: 390  ---------RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH------ 434

Query: 596  SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKL 655
                 KH+++ + Q+    +   +   K ++E      E     LK+  +E +  +  KL
Sbjct: 435  ---EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 656  KHKEREKEKHKKE-------IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETED 708
            + +ER +++ ++E        E  +++ K ++  + LQ+ +  +++  +E     +E  +
Sbjct: 492  EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE----QEERRE 547

Query: 709  LFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK 768
              L  E E   LE++ + ++  ++ +  +++ + +E   +++R  +K+E E+   E+++K
Sbjct: 548  QLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQR--LKREQEERL-EQRLK 603

Query: 769  DLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI 828
              +EE E +  ++  E   L     EE     L++ E   E++++ ++  +E+ E+R Q 
Sbjct: 604  --REEVERLEQEERRE-QRLKREEPEEERRQQLLKSEEQEERRQQQLR--REQQERREQR 658

Query: 829  KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE-----CVDKIKEKDKLYSHHTEKCHK 883
             +++ E+ ER     E+++K EH+ E+ + +L+E       ++IK +   +    E    
Sbjct: 659  LKRE-EEEER----LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES-EA 712

Query: 884  EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEY 943
            +  +SK  +  +K   +E  R + +++  + + E E    E +  H  +++ +Q  +  +
Sbjct: 713  DARQSKVYSRPRK---QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769

Query: 944  -----SKSEKGKNKEKDRE--LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 996
                  KSE+G+ +   R    +++E+    E       + + EE++       + + EK
Sbjct: 770  QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 997  PLSLKEKTKDEPLKTPD-----GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
             L   E  ++E L+  +      +E+D   +D +R + +++ +D+ +    L+ + +  +
Sbjct: 830  ELQFLE--EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ-KWRWQLEEERKRRR 886

Query: 1052 PKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLR 1111
                + PA ++   KE++L+ ++  +   E     +  E E+ +++ +E+++Q+E++ LR
Sbjct: 887  HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLR 945

Query: 1112 -NRNCLELKIKDKEKTKHTPTESKNKEL 1138
              R     + ++++  K    + K ++L
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQL 973



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 147/896 (16%), Positives = 388/896 (43%), Gaps = 138/896 (15%)

Query: 294  EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 353
            +E E   + E  L  ++E     E  +        + ++ +  ++  + + ++ L  + P
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRR-----QELERQYREEEEVQQEEEQLLREEP 1158

Query: 354  LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKS 413
                  E E +  ++EE+ +  ++  +LR+EQ K  +   E+   + ++E+    K  + 
Sbjct: 1159 EKRRRQELERQYREEEELQQ--EEEQLLREEQEKRRQ---ERERQYREEEELQRQKRKQR 1213

Query: 414  KKQKPSRV-LYSSTESSDEEALQNKKI------STSCSVIPETSNSDMQTKKEYV-VSGE 465
             + +  R  L    E   E A+++ K+      +     + ++   D Q++++   + GE
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273

Query: 466  HKQKGKVKRKLKNQNKNK-----ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGN 520
             +++ + + + + Q +++     E  E +++KE K   R +        +  E+ R    
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333

Query: 521  FRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQ--- 577
              + F  ++                    L E++  PL+++               Q   
Sbjct: 1334 TDRKFREEEQL------------------LQEREEQPLRRQERDRKFREEELRHQEQGRK 1375

Query: 578  ----PDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF 633
                   +R    E +FL E   ++ C+ +E+   Q D   +F E+   ++  ++    F
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLR-CQEREQQLRQ-DRDRKFREEEQ-QLSRQERDRKF 1432

Query: 634  ENSDCTLKKMDKEGKTLKKHKLKHKEREK----------EKHKKEIEGEKEKYKTKDSAK 683
               +  +++ ++E K L++ +   +ER +          E+ ++++  ++   K  +  +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 684  ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 743
            +L+R  E DR+F +E   +S E E  FL  E +   L ++ +  K +++++  + +   +
Sbjct: 1493 QLRRQ-ERDRKF-REQELRSQEPERKFLEEEQQ---LHRQQRQRKFLQEEQQLRRQERGQ 1547

Query: 744  ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 803
            +R  +++RD+  +E      EE+++  +EE++    ++D +F               L E
Sbjct: 1548 QR--RQDRDRKFRE------EEQLRQEREEQQLSRQERDRKF--------------RLEE 1585

Query: 804  KEIDIEKQEKHIKESKE---KPEKRSQIK-EKDIEKMERKTFEKEKKIKHEHKSEKDKLD 859
            +++  ++QE+   E ++   + E + Q++ E+D +  E +   +E++ +  H+ E+D+  
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645

Query: 860  LSECVD-KIKEKDKLYSH-------HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 911
            L E    + +E+++   H         E+  +EGE            +++  R++ DRK 
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE------------EQQLRRQERDRKF 1693

Query: 912  DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 971
             +E+ +  R   E K     ++  +Q    ++ + E+ + + +  +L ++E+ R      
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR-----K 1748

Query: 972  ITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD 1031
            I   + ++ E++                L+ + +D   +  +   ++++++ + R +E D
Sbjct: 1749 ILEEEQLRPEREEQ-------------QLRRQERDRKFREEEQLRQEREEQQL-RSQESD 1794

Query: 1032 KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD--LMQTSFERMLSLKDL 1089
            +   K +    L+ + E  + +P+          ++ +L   +  L Q    +  + +  
Sbjct: 1795 R---KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851

Query: 1090 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSE 1145
              ++  ++ ++++ Q+E+++ R     E K++++   +    E +++++   KS E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQER--ERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 149/782 (19%), Positives = 336/782 (42%), Gaps = 76/782 (9%)

Query: 279  QANKHGERPVDVAETEELELLLKREVPLSDDDES----YTDSEEAQSVNPSSV----DEN 330
            Q  +  ER     E EEL+   +++    +D  S      + E+  +V  + V     EN
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 331  IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ-RKEN 389
                  +DS + + +    S+  L   L E + +D + E       DRH   +EQ  +E 
Sbjct: 1248 EQFRQLEDSQLRDRQ----SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303

Query: 390  EPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPET 449
            + EA++    +++EK    +  + K+++      +  +  +EE L  ++           
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQE----TDRKFREEEQLLQEREEQPL----RR 1355

Query: 450  SNSDMQTKKEYVVSGEHKQKGK--VKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 507
               D + ++E +    H+++G+  ++ + + + + +E + LK+E++ +   R   L    
Sbjct: 1356 QERDRKFREEEL---RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-- 1410

Query: 508  GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 567
              D   K REE   ++    + D           +  +    L E+Q   L+QE  +   
Sbjct: 1411 --DRDRKFREEE--QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ--LRQERHRKFR 1464

Query: 568  SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 627
                     +   +     + +FL E   ++  +   K + Q+             ++ +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE-------------LRSQ 1511

Query: 628  DHSPTFENSDCTLKKMDKEGKTLKKHK-LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ 686
            +    F   +  L +  ++ K L++ + L+ +ER +++ +      +E+ + +   +E Q
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571

Query: 687  RS-VEFDREF-WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 744
             S  E DR+F  +E   +  E E  F+  E +    E + +L +  +D K  +++ + +E
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE-RDRKFREDEQLLQE 1630

Query: 745  RNFKEERDKIKKESEKSFREEKIKDLKEEREN-IPTDKDSEFTSLGMSAIEESIGLHLVE 803
            R   EE+   ++E ++ F EE+ +  ++ERE  +  D+D +F         E   L    
Sbjct: 1631 R---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF--------REEEQLLQEG 1679

Query: 804  KEIDIEKQEKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHK----SEKDK 857
            +E  + +QE+  K  +E+ + R Q +E+    E+ + +  E E+K + E +    +E+++
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 858  LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 917
            L   E   KI E+++L     E+  +  E+ +     ++     + ++   ++ D++  E
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799

Query: 918  KERHLAESKEKHLMEKKNK-----QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINI 972
            +E+   E +E+ L  ++       + +  +  + E+   +E+DR+   +E+   +E    
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 973  TNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK 1032
               +  QEE++    +  +   E+   ++ + K+E      G+ K ++ K   R  E   
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREE--HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGT 1917

Query: 1033 HK 1034
            H+
Sbjct: 1918 HQ 1919



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 154/892 (17%), Positives = 374/892 (41%), Gaps = 95/892 (10%)

Query: 292  ETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSK 351
            + E  E  LKRE P  +  +    SEE +      +        E+     E ++ L  +
Sbjct: 612  QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671

Query: 352  TPLPSALD--EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPK 409
                   +  E E  +++ E+  + I  R I + + + E+E +A ++ ++++  K    +
Sbjct: 672  LKREHEEERREQELAEEEQEQARERIKSR-IPKWQWQLESEADARQSKVYSRPRKQEGQR 730

Query: 410  SFKSKKQKPSRVLYSSTESSDEEA-LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
              + +++K  R         +E A  Q ++         +    +   +    +S     
Sbjct: 731  RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 469  KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 528
            + + +R+L+ + + +  Q    E+E KE  R         L   E+  +     ++   +
Sbjct: 791  REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 529  DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSE---------MSLQPD 579
            ++                  GL E Q     QE  +        E         +  +P 
Sbjct: 851  EEED----------------GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894

Query: 580  LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 639
            L      E + L E       + +EK + Q+    E   +   +++ E+     E  +  
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQ---ERQYREEEQLQQEEEQLLREERE-K 950

Query: 640  LKKMDKEGKTLKKHKLKHKERE---KEKHKKEIEGEKEKYKTKDSAKELQRSVEFD---- 692
             ++ ++E +  K  KL+ KE +   +E  K+  +  ++KY+ ++  ++ +  +  +    
Sbjct: 951  RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010

Query: 693  --REFWKENFFKSDETEDLFLNMEHESLTLEKKSK--LEKNIKDDKSTKEKHVSKERNFK 748
              R+ W+  + K DE     L  E E L  E++ K  L++  +  +  +E    +E+   
Sbjct: 1011 RRRQEWERQYRKKDE-----LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 749  EERD-KIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSA-IEESIGLHLVEKEI 806
            EER+ + ++E E+ +R+E+  +L++E E +  ++  +           E   L   E+++
Sbjct: 1066 EERETRRRQELERQYRKEE--ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123

Query: 807  DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
              E++EK  ++  E+  +  +  +++ E++ R+  EK ++ + E +  +++       + 
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-------EL 1176

Query: 867  IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
             +E+++L     EK  +E E+            + +  E++ R+  K++   E   ++ K
Sbjct: 1177 QQEEEQLLREEQEKRRQERER------------QYREEEELQRQKRKQRYRDEDQRSDLK 1224

Query: 927  EKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
             +   EK+N   DN  Y    KG+  E+ R+L+  +  RD++S    + +H+  E++   
Sbjct: 1225 WQWEPEKENAVRDNKVYC---KGRENEQFRQLEDSQ-LRDRQSQQ--DLQHLLGEQQ--- 1275

Query: 987  VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLK 1046
                + + ++    +++ +  P +    +E+ K+ K  DR  + +K         LL+ +
Sbjct: 1276 ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK--------QLLREE 1324

Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKK---HKEKIK 1103
             E  + + ++    ++     +      L +   +R    ++L  ++  +K    +++++
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384

Query: 1104 QKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
            ++E+ER   +   +L+ +++E+      + K +E  +  S +  D   +E++
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 112/557 (20%), Positives = 259/557 (46%), Gaps = 66/557 (11%)

Query: 625  KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKE 684
            + E+    FE  D  L     E +  ++ + K +E+E+E  + E + EK++   +   + 
Sbjct: 114  RQEEDQRRFEPRDRQL-----EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168

Query: 685  LQRSVEFDREFWKENFFKSDETEDLFLNMEHES------LTLEKKSKLEKNIKD-DKSTK 737
                +   R+ W+E   +  E E L     HE+        L ++  LE   K  ++  +
Sbjct: 169  RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228

Query: 738  EKHVSKERNFKEERDK--------IKKESEKSFREE--KIKDLKEERENIPTDKDSEFTS 787
            ++   ++R F+EE +K        ++KE EK   EE  + ++L+EE E +   +  E   
Sbjct: 229  QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL---RKLERQE 285

Query: 788  LGMSAIEESIGLHLVEKEIDI-----EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 842
            L     EE      + +E  +     E++ +  +E +E+ E+R Q +E+  +++ R+  E
Sbjct: 286  LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345

Query: 843  -KEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH---HTEKCHKEGEKSKNTAAIKKTD 898
             +E++++ E + E+ +  L    ++ + + +L        E+  +  ++ +    +++  
Sbjct: 346  RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405

Query: 899  ----------DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEK 948
                      +++  RE+  R+  +E+  +++H  E +E+ L   K +Q +  ++ K E+
Sbjct: 406  QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL---KREQEERRDWLKREE 462

Query: 949  GKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEP 1008
             + +  ++E  K++  RD+E         ++EE++    +  + Q  +    +E+ +++ 
Sbjct: 463  -ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE---QEERREQR 518

Query: 1009 LKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1068
            LK  + +E+ ++    ++   R++ + + Q+     LK E +K   +     +  R +E+
Sbjct: 519  LKRQEEEERLQQRLRSEQQLRREQEERREQL-----LKREEEKRLEQERREQRLKREQEE 573

Query: 1069 RLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1128
            R   D L++   ER       E E+   + ++++K++E ERL      E ++K +E    
Sbjct: 574  R--RDQLLKREEERRQQRLKREQEE---RLEQRLKREEVERLEQEERREQRLKREE---- 624

Query: 1129 TPTESKNKELTRSKSSE 1145
             P E + ++L +S+  E
Sbjct: 625  -PEEERRQQLLKSEEQE 640



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 144/906 (15%), Positives = 373/906 (41%), Gaps = 133/906 (14%)

Query: 292  ETEELELLLKREVPLSDDDESYTDSEEA---QSVNPSSVDENIDSETEKDSLICESKQIL 348
            + E  E  L+RE     + +   + EE    Q +     +E  + +  ++  +   +Q+ 
Sbjct: 331  QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 349  PSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 408
              +        E + + +      + +     LR+EQ+   E E E+     +QE+    
Sbjct: 391  REQ----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER---- 442

Query: 409  KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
            +  + K+++  R  +   E                    ET   + + +K+ +   + ++
Sbjct: 443  REQRLKREQEERRDWLKREE-------------------ETERHEQERRKQQLKRDQEEE 483

Query: 469  KG----KVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKS 524
            +     K++ + + + + +  Q+L++E+E +   R+        L   ++ R E   R+ 
Sbjct: 484  RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ--QRLRSEQQLRRE 541

Query: 525  FSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 584
               + +  L                   ++   L+QE  +  L     E   Q  L R +
Sbjct: 542  QEERREQLL-----------------KREEEKRLEQERREQRLKREQEERRDQL-LKREE 583

Query: 585  NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 644
                + L      +    +++ K ++   LE  E+   ++K E+  P  E     LK  +
Sbjct: 584  ERRQQRLKREQEERL---EQRLKREEVERLEQEERREQRLKREE--PEEERRQQLLKSEE 638

Query: 645  KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
            +E +  ++ + + +ER +++ K+E E E+ + + K   +E +R  E   E          
Sbjct: 639  QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE---------- 688

Query: 705  ETEDLFLNMEHESLTLEKKSKLEKNIKDDK--STKEKHVSKERNFKEERDKIKKESEKSF 762
            E E     ++      + + + E + +  K  S   K   + R  ++E  + ++ESE  +
Sbjct: 689  EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748

Query: 763  REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 822
            +EE+    +++ E    ++  +FT    +  +   G   +     + +Q +    ++E+ 
Sbjct: 749  QEEERAHRQQQEE----EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804

Query: 823  EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 882
            ++  +   ++ EK +R+   +E++ + +   E+++L   E   +++E++       E+  
Sbjct: 805  QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864

Query: 883  KEGEKSKNTAAIKKTDDREKSREKMDRKHD-KEKPEKERHLAESKEKHLMEKKNKQSDNS 941
             + ++       +  ++R++ R  +  K   +E+  KE+ L + +E+ L  ++       
Sbjct: 865  SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE------- 917

Query: 942  EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
                      +EK R  +++ + R++E +     + ++EE++       + Q+ K   L+
Sbjct: 918  ----------REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967

Query: 1002 EKTKDEPLKTPDGKEKDKKDKDIDRYKERD--------------------------KHKD 1035
            +K +    + P+ + + +++K   +Y+E +                          + KD
Sbjct: 968  QKEEQLLGEEPEKRRRQEREK---KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024

Query: 1036 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1095
            ++Q      L+ E +K + +     ++ + +E+  +  +  Q   E   + +  E+E+ +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQ----ERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080

Query: 1096 KKHKEKIKQKEKERL------RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1149
            +K +E+++Q+E++ L      R R   E + +++E+ +    +   +E  + +  E+   
Sbjct: 1081 RK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139

Query: 1150 YTKEKQ 1155
            Y +E++
Sbjct: 1140 YREEEE 1145



 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 83/515 (16%), Positives = 231/515 (44%), Gaps = 53/515 (10%)

Query: 670  EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
            E ++ +   K+S  + +R  E  R F         E  D  L  E      +K+ + E+ 
Sbjct: 97   EEKRARCDGKESLLQDRRQEEDQRRF---------EPRDRQLEEEPGQRRRQKRQEQERE 147

Query: 730  IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER-ENIPTDKDSEFTSL 788
            + + +   EK    E+  ++ RD+      + ++E + +  +EE+ ++    +  EF   
Sbjct: 148  LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207

Query: 789  GMSAIEESIGLHLV-EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKI 847
                  E + L     +E   +++E+  +  +E+ EK  + +E  + K E K  E+E + 
Sbjct: 208  EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267

Query: 848  KHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKM 907
            + E + E+++L       +  E+ +L     E+  ++ ++ +    +++  + E+  ++ 
Sbjct: 268  QRELQEEEEQL-------RKLERQELRRERQEE-EQQQQRLRREQQLRRKQEEERREQQE 319

Query: 908  DRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
            +R+  +E+ E++    E + +   E++ +Q    E  +  + +   +++E +++E+   +
Sbjct: 320  ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379

Query: 968  ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027
            E   +   + ++ E++  +    + + E+ L  +++ + E        ++ ++++ + R 
Sbjct: 380  EQ-QLRREQQLRREQQ--LRREQQLRREQQLRREQQLRRE--------QQLRREQQLRRE 428

Query: 1028 KERDKHKDKI-QINSLLKLKSEADKPKP---KSSPASKDTRPKEKRLVNDDLMQTSFERM 1083
            +E ++H+ K  Q     +LK E ++ +    +     +  + + K+ +  D  +   ER 
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 1084 LSLKDLEIEQWHKKHKEKIK-------------QKEKERLRNRNCLELKIKDKEKTKHTP 1130
            L L++ E  +  ++ +++++             Q+E+ERL+ R      ++ +++ +   
Sbjct: 489  LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR------LRSEQQLRREQ 542

Query: 1131 TESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQ 1165
             E + + L R +   +     +++  ++    R Q
Sbjct: 543  EERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 70/438 (15%), Positives = 203/438 (46%), Gaps = 45/438 (10%)

Query: 749  EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
            +E  + + + ++S  +++ ++ +++R   P D+           +EE  G    +K    
Sbjct: 96   DEEKRARCDGKESLLQDRRQE-EDQRRFEPRDRQ----------LEEEPGQRRRQKR--- 141

Query: 809  EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 868
            ++QE+ + E +E+ EK+ +++++D ++ + + + + ++ +   +   ++  L  C     
Sbjct: 142  QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK---- 197

Query: 869  EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
                   H TE+   E +  +      +   RE+ +++   + D+   E+E      +E 
Sbjct: 198  ------GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251

Query: 929  HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS--------KHIQE 980
             L +++ K  +     + E  + +E+ R+L+++E  R+++               +  QE
Sbjct: 252  VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311

Query: 981  EKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD-------GKEKDKKDKDIDRYKERDKH 1033
            E++    +  + Q E+    +E+ + +  +  +        +E++++ ++    +E+++ 
Sbjct: 312  EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371

Query: 1034 KDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
            + + Q+    +L+ E    + +     +  R +E++L  +  ++   +++   + L  EQ
Sbjct: 372  RREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRRE-QQLRREQQLRREQ 429

Query: 1094 WHKKHKEKIKQKEKERLRNRNCLELK--IKDKEKTKHTPTESKNKELTRSKSSEVTDAYT 1151
              ++H++K +Q+ +E+   R   E +  +K +E+T+    E + ++L R +  E  + + 
Sbjct: 430  EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489

Query: 1152 K--EKQPKDAVSNRSQSV 1167
            K  E++ ++    R Q +
Sbjct: 490  KLEEEERREQQERREQQL 507


>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
           sapiens]
          Length = 929

 Score =  101 bits (252), Expect = 7e-21
 Identities = 153/621 (24%), Positives = 250/621 (40%), Gaps = 94/621 (15%)

Query: 284 GERPVDVAETEELELLLKREVPLSDDDESYT----------DSEEAQSVNPSSVDENIDS 333
           G+RP+D  E EEL  + KR   LS   ++             S   Q + P     ++  
Sbjct: 177 GKRPLDSPEAEELPAM-KRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQD 235

Query: 334 ETEKDSLICESKQILP-SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
            T+      E   + P +K+ +P+A               K ++ +    K + K + P 
Sbjct: 236 STDLAPPSPEPPMLAPVAKSQMPTA---------------KPLETKSFTPKTKTKTSSPG 280

Query: 393 AEKTHLFAKQEKAFY------PKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST---SC 443
            +       Q  A        PK+   +K+ P R       S   ++ ++ K++T     
Sbjct: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------SKSPKSPKSPKVTTHIPQT 333

Query: 444 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 503
            V PET N          +S E  Q  +++        N ENQ  K          + + 
Sbjct: 334 PVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAV--------VADK 385

Query: 504 TVNTGLD------CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP 557
           T+   +D      C+E  RE   F   FS   ++   +F      SPK   G   + +TP
Sbjct: 386 TIEASIDAVIARACAE--REPDPFE--FSSGSESEGDIF-----TSPKRISG--PECTTP 434

Query: 558 LKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG 617
                       GS+ + L       DN+ +        V+  K    S    +F     
Sbjct: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS 494

Query: 618 EKSNAKIKDEDHSPTFENSDC-----TLKKMDKEGKTLKKHKLKHKEREKEKHK-KEIEG 671
              +    +  H    E +         KK+ KE KT  K K K ++RE+EK K K+   
Sbjct: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSK 554

Query: 672 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
           EK+K K K+  KE  R  ++    WKE F K +E +     ++ E   ++ K KL+  + 
Sbjct: 555 EKDKVKEKEKDKETGRETKYP---WKE-FLKEEEADPYKFKIK-EFEDVDPKVKLKDGLV 609

Query: 732 DDKSTKEKHVSKERNFKEERDKIKKESEK---SFREEKIK----DLKEERENIPTDKDSE 784
             +  K K   K+R  K ++DK K+E EK     RE+K+K     L    + +     S 
Sbjct: 610 RKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668

Query: 785 FTSLGMSAIEESIGLHLVEK------EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
            T+  + A+  S+   L EK      ++  ++++K  KE K+K EK  + KEK+ EK E+
Sbjct: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK-EK 727

Query: 839 KTFEKEKKIKHEHKSEKDKLD 859
           +  EK +K K +HK EK K++
Sbjct: 728 REREKREKEKEKHKHEKIKVE 748



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 74/228 (32%), Positives = 102/228 (44%), Gaps = 42/228 (18%)

Query: 928  KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITNSKHIQEEKKSSI 986
            K  M+KK KQ D       EK KNK+K +E DK KEK +DKE+           E K   
Sbjct: 530  KTKMKKKEKQRDRER----EKDKNKDKSKEKDKVKEKEKDKET---------GRETKYPW 576

Query: 987  VDGNKAQHEKPLSLKEKT---KDEPLKTPDGKEKDKKDKDIDRYKERD---KHKDKIQIN 1040
             +  K +   P   K K     D  +K  DG  + +K+K  D+ K+R+   K KDK +  
Sbjct: 577  KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE-K 635

Query: 1041 SLLKLKSEADKPK---------------PKSSPASKDTRPKEKRLVNDDLMQTSFERMLS 1085
              +K K   DK K               P  SPA+    P     +   L +  FE    
Sbjct: 636  EKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEK 695

Query: 1086 LKDLE-----IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1128
            +K+ E      E+  KK KEK ++KEKER + +   E + K+KEK KH
Sbjct: 696  VKEKEKKKDKKEKKKKKEKEK-EKKEKEREKEKREREKREKEKEKHKH 742



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 55/268 (20%)

Query: 816  KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 875
            K  +EK +  S ++ K   K E KT  K+K+ + + + EKDK       DK KEKDK+  
Sbjct: 507  KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK-----DKSKEKDKV-- 559

Query: 876  HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
                   KE EK K T    K   +E  +E+          E + +  + KE   ++ K 
Sbjct: 560  -------KEKEKDKETGRETKYPWKEFLKEE----------EADPYKFKIKEFEDVDPKV 602

Query: 936  KQSDNSEYSKSEKGKNKEKDRELDKKEK-SRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
            K  D     + EK K+K+KDRE  KK+K  R+KE +     K  +++ K+          
Sbjct: 603  KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV---KDKGREDKMKAP--------- 650

Query: 995  EKPLSLKEKTKDEPLKTPDGKEK-------------DKKDKDIDRYKERDKHKDKIQINS 1041
              PL L  K    PL +P    +             +K  ++ ++ KE++K KDK +   
Sbjct: 651  APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE--- 707

Query: 1042 LLKLKSEADKPKPKSSPASKDTRPKEKR 1069
              K K E +K K K     K+ R +EKR
Sbjct: 708  -KKKKKEKEKEK-KEKEREKEKREREKR 733



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 71/250 (28%), Positives = 123/250 (49%), Gaps = 40/250 (16%)

Query: 721 EKKSKL------EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
           E+K+KL      +K +K +  TK K   K+R+ + E+DK K   +KS  ++K+K+ ++++
Sbjct: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK---DKSKEKDKVKEKEKDK 566

Query: 775 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDI 833
           E   T +++++        EE+       KE +    +  +K+   + EK + + K+KD 
Sbjct: 567 E---TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623

Query: 834 EKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKD-KLYSHHT------------- 878
           EK ++   ++EK K+K + + +K K      V   KE    L+S  T             
Sbjct: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683

Query: 879 ---EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
              EK  +E EK K     KK D +EK ++K   + +KEK EKER     KEK   EK+ 
Sbjct: 684 VLPEKLFEEKEKVKEKE--KKKDKKEKKKKK---EKEKEKKEKER----EKEKREREKRE 734

Query: 936 KQSDNSEYSK 945
           K+ +  ++ K
Sbjct: 735 KEKEKHKHEK 744



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 75/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)

Query: 803  EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH-------EHKSEK 855
            E +  ++K+EK     +EK + + + KEKD  K + K  E  ++ K+       E +++ 
Sbjct: 528  ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587

Query: 856  DKLDLSECVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHD 912
             K  + E  D   K+K KD L     EK HK+ +K +     K  D REK + K   + D
Sbjct: 588  YKFKIKEFEDVDPKVKLKDGLVRKEKEK-HKDKKKDREKGK-KDKDKREKEKVKDKGRED 645

Query: 913  KEK--------PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 964
            K K        P KE  L                        +  + KEK +E +KK+  
Sbjct: 646  KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705

Query: 965  RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDI 1024
            ++K+       K  ++EKK    +  K + EK    KEK K E +K             I
Sbjct: 706  KEKK-----KKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE--PVALAPSPVI 758

Query: 1025 DRYKER-DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1066
             R   R    +DKI I+ ++        P P++ PA    RPK
Sbjct: 759  PRLTLRVGAGQDKIVISKVV--------PAPEAKPAPSQNRPK 793



 Score = 39.7 bits (91), Expect = 0.031
 Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 14/221 (6%)

Query: 1056 SSPASKDTRPKEKRLVNDDL--MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1113
            SSP+     P+    V ++   + +S E    LK     +  KK K++ +++EK++ +++
Sbjct: 493  SSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK 552

Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVM 1173
            +  + K+K+KEK K T  E+K       K  E      K K+ +D        VD K  +
Sbjct: 553  SKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED--------VDPKVKL 604

Query: 1174 TLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDF 1233
              G      +   ++    E  K     R    +     ED     +  P PP+      
Sbjct: 605  KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK----MKAPAPPLVLPPKE 660

Query: 1234 MLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIK 1274
            +     S  + S+ P +  +  P L E+  +    + E+ K
Sbjct: 661  LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 29/169 (17%)

Query: 991  KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1050
            K +    + +K+K K E LKT    +  KK+K  DR +E+DK+KDK +           +
Sbjct: 512  KTKLPSSVEVKKKLKKE-LKT----KMKKKEKQRDREREKDKNKDKSK-----------E 555

Query: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
            K K K     K+T             +T +     LK+ E + +  K KE      K +L
Sbjct: 556  KDKVKEKEKDKETG-----------RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604

Query: 1111 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
            ++    + K K K+K K      K+K+  + +  +V D   ++K    A
Sbjct: 605  KDGLVRKEKEKHKDKKKDREKGKKDKD--KREKEKVKDKGREDKMKAPA 651


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  100 bits (250), Expect = 1e-20
 Identities = 53/127 (41%), Positives = 79/127 (62%), Gaps = 2/127 (1%)

Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
           R  TPLH AA    V  V+ L+  GA+V+ KD  G  PLH AC+ G+Y+VA++L+  GA 
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584

Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL--LLK 301
           VN   L   TPLH++A+ G  +I KLLL+HG +P + N+ G  P+D+ +  + ++  LL+
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLR 644

Query: 302 REVPLSD 308
            +  L D
Sbjct: 645 GDAALLD 651



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 51/134 (38%), Positives = 76/134 (56%), Gaps = 2/134 (1%)

Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
           D VN R+ +G   TPLH+AA   +++  + L+  GA+VN +D  G  PLH A + G+ DV
Sbjct: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727

Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAET 293
           A +LI   A VN       TPLH++A  G   +  LLL HG +P   N+ G+ P+D+   
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787

Query: 294 EELELLLKREVPLS 307
           +++  LL   +P S
Sbjct: 788 DDVSALLTAAMPPS 801



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 49/120 (40%), Positives = 71/120 (59%)

Query: 184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
           R  TPLH+AA    VK V+ L+  GA+V+ KD     PLH AC+ G+Y+V ++L+  GA 
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269

Query: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 303
           VN   L   TPLH++AS    ++  LLL +G +P   N H +  +D+A T +L+  L  E
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 48/119 (40%), Positives = 68/119 (57%), Gaps = 2/119 (1%)

Query: 176 DKVNKRNERGE--TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDV 233
           +KVN R+  G   TPLH AA  G    V+ L+  GANV  +D  G  PLH AC+ G+ +V
Sbjct: 47  EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106

Query: 234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
             +L+  GAD N +   + TPLH++A  G  D+  +LL+HG  P   N  G   +D+A+
Sbjct: 107 VNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 1/93 (1%)

Query: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
           V+ +++ G  PLH A   G  +  + L+  GA VNV D   +TPLHEA   G Y++ K+L
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 238 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
           +  GAD   +  D +TPL D    G  DI  LL
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLL 643



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/148 (31%), Positives = 70/148 (47%), Gaps = 6/148 (4%)

Query: 180 KRNERGETPLHMAAIRG--DVKQVKELI-SLGANVNVKDFAGWTPLHEACNVGYYDVAKI 236
           K  +  ET LH AA       KQ+ EL+   GAN+N K     TPLH A    + DV ++
Sbjct: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418

Query: 237 LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
           ++   A VN       T LH +A  GH    +LLL +G +P   +  G   + +   E +
Sbjct: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-NENV 477

Query: 297 ELLLKREVPL--SDDDESYTDSEEAQSV 322
           + LL+  + L  S+ D    ++ +A  V
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDV 505



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 28/86 (32%), Positives = 44/86 (51%)

Query: 189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 248
           L  A    + K +  L  L  N +  D    TPLH A       + ++L+  GADV+ + 
Sbjct: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241

Query: 249 LDDDTPLHDSASSGHRDIVKLLLRHG 274
             D  PLH++ S GH ++ +LL++HG
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHG 267



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 4/115 (3%)

Query: 132 SERKQMALLMQMTARDNSPD---STPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETP 188
           +E K MALL  +    ++ D   STP H +      K          D V+ +++    P
Sbjct: 189 NEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD-VHAKDKGDLVP 247

Query: 189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGAD 243
           LH A   G  +  + L+  GA VN  D   +TPLHEA +    +V  +L++ GAD
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 4/109 (3%)

Query: 162 PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTP 221
           P +K+      R+   +N++ +   TPLH+A+ +     V+ ++   A VN  D  G T 
Sbjct: 377 PKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436

Query: 222 LHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
           LH A   G+    ++L++ G D N   L   T L      G+ ++ +LL
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL----QMGNENVQQLL 481


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  100 bits (248), Expect = 2e-20
 Identities = 132/577 (22%), Positives = 233/577 (40%), Gaps = 79/577 (13%)

Query: 547  SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 606
            SCG    +S   K+E  +   S  SS  S   D      + S+     S+ +    K K 
Sbjct: 173  SCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKK 232

Query: 607  KHQKDFHLEFGEKSNAK----------------------IKDEDHSPTFENSDCTLKKMD 644
            KH+K+      EK   K                      ++ E+  P  EN     K   
Sbjct: 233  KHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPP 292

Query: 645  KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ----RSVEFDREFWKENF 700
            K  +  +K++ + +ERE      +    + +     S ++++    R           + 
Sbjct: 293  KADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352

Query: 701  FKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKS----TKEKHVS----KERNFKEERD 752
            F+  ET   +   E +     + S  E+ IK DKS     KE   S    KER   + R+
Sbjct: 353  FRRSETPPHW-RQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRN 411

Query: 753  KIKKESEKSFREEKIKDLK---EERE-NIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
              +  + K+ +E+K+KD K   +ER+    ++KD ++ +      +        EK    
Sbjct: 412  VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471

Query: 809  EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS---EKDKLDLSECVD 865
            E+  KH     E+   RS+ K +D E ++ K  + + K K + +S   EK K   S+  +
Sbjct: 472  ERDSKH--NRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNE 529

Query: 866  ----KIKEKDKLYSHHTEKCH-KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKER 920
                K KEKD+     + +C   +G+ S N+   +++  R++SR    R HD+++     
Sbjct: 530  HDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDR----- 584

Query: 921  HLAESKEKHL---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKE--KSRDKESINITNS 975
              + SKE H     E + +    S   ++  G+++ KDR   +++   S  +ES +    
Sbjct: 585  --SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKD 642

Query: 976  KHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGKEKDKKDKDIDRY-KERD 1031
            K+  +E KSS        H K  S  EK   +K     + +   + K D+D   + K + 
Sbjct: 643  KYRNQESKSS--------HRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQ 694

Query: 1032 KHKDKIQINSLL------KLKSEADKPKPKSSPASKD 1062
              +D    +S+L      K++S  +K   KS     D
Sbjct: 695  SSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEND 731



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 129/630 (20%), Positives = 260/630 (41%), Gaps = 69/630 (10%)

Query: 408  PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 467
            PKS K KK++  R   SS+ SS      +   S S S   ++S+S+  T          +
Sbjct: 179  PKS-KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSS---DSSDSESAT----------E 224

Query: 468  QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 527
            +K K ++K   +N  K  +E K+ K+ K++              SE    E   + +  P
Sbjct: 225  EKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSE----------SEAENLEAQPQSTVRP 274

Query: 528  KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE 587
            ++   +        KSP  +    EK+    ++E  + C  P S   S Q  L+      
Sbjct: 275  EEIPPIPENRFLMRKSPPKA---DEKERKNRERERERECNPPNSQPASYQRRLL------ 325

Query: 588  SEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
                     V     K K +  + +      +S  + +  +  P +           +E 
Sbjct: 326  ---------VTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWR----------QEM 366

Query: 648  KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 707
            +  ++ ++   ER  +  K E+   KE  ++    KE + +   D     E+  + +E E
Sbjct: 367  QRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKIT---DHRNVSESPNRKNEKE 423

Query: 708  DLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFR-EEK 766
                + +  S   + +   EK+ K     K++  SK R+  +E+ K K+   K  R EEK
Sbjct: 424  KKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEK 483

Query: 767  IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 826
                + +  +    K+ E  S      +E        K+++ +  E    +SKEK ++R+
Sbjct: 484  RMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEK-DRRA 542

Query: 827  QIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE 886
            Q + ++ +  + K     +  +     ++ +   S   D+ + + K Y  + E+ ++   
Sbjct: 543  QSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRG 602

Query: 887  KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 946
            +S++    +    R +S+++  R+ D    E+E   + +K+K+   +++K S   E S+S
Sbjct: 603  RSRSRER-RTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKY-RNQESKSSHRKENSES 660

Query: 947  EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD 1006
            EK +   K R+ +    SR+K        K  +++   S +  +   +E   S+ +  +D
Sbjct: 661  EK-RMYSKSRDHNSSNNSREK--------KADRDQSPFSKIKQSSQDNELKSSMLKNKED 711

Query: 1007 EPLKTPDGKEKDK-KDKDIDRYKERDKHKD 1035
            E +++   KE  K K ++ D   E++K  D
Sbjct: 712  EKIRSSVEKENQKSKGQENDHVHEKNKKFD 741



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 121/637 (18%), Positives = 245/637 (38%), Gaps = 95/637 (14%)

Query: 301 KREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDE 360
           KR    S    S +DS+ +     SS   + +S TE+ S   + K    S+         
Sbjct: 189 KRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSR--------- 239

Query: 361 YEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR 420
            + K +  +            RK+ +K    E+E  +L A+ +    P+      +    
Sbjct: 240 -KHKKEKKK------------RKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPEN-RF 285

Query: 421 VLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN 480
           ++  S   +DE+  +N++        P  S      ++  V     K KG+  R+ +  +
Sbjct: 286 LMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPS 345

Query: 481 KNKENQELKQEKE----GKENTRITNLTVNTGL-----DCSEKTREEGNFRKSFSPKDDT 531
           +++     ++ +      +E  R   + V++G      D SE    + N R     K+  
Sbjct: 346 RSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK 405

Query: 532 SLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFL 591
                H +  +SP              K E  K      S+  S + D+ R  N+E +  
Sbjct: 406 ITD--HRNVSESPNR------------KNEKEKKVKDHKSN--SKERDIRR--NSEKDDK 447

Query: 592 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
            ++   K  K K +SK +        EKS +K +D  H+   E      K+M    K   
Sbjct: 448 YKNKVKKRAKSKSRSKSK--------EKSKSKERDSKHNRNEE------KRMRSRSKGRD 493

Query: 652 KHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFL 711
              +K KE++ +   K    ++E+ ++K+ +K+L+               KS+E +    
Sbjct: 494 HENVKEKEKQSDSKGK----DQERSRSKEKSKQLES--------------KSNEHD---- 531

Query: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLK 771
                S + EK  + +   ++   TK KH    R  +  R + +    +S   ++ +   
Sbjct: 532 ----HSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRS 587

Query: 772 EERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEK 831
           +E       ++ E+   G S   E        +  D  ++ +    S E+ E +S+ K+K
Sbjct: 588 KEYHRY---REQEYRRRGRSRSRERRTPPGRSRSKD-RRRRRRDSRSSEREESQSRNKDK 643

Query: 832 DIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNT 891
              +  + +  KE     +    K +   S    + K+ D+  S  + K  +  + ++  
Sbjct: 644 YRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFS-KIKQSSQDNELK 702

Query: 892 AAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
           +++ K  + EK R  +++++ K K ++  H+ E  +K
Sbjct: 703 SSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 94/451 (20%), Positives = 184/451 (40%), Gaps = 83/451 (18%)

Query: 751  RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 810
            + K+KKE +K          K    +  +  DS+ +S   S+ + S      E     EK
Sbjct: 180  KSKVKKEEKKRH--------KSSSSSSSSSSDSDSSSDSQSSSDSSDSESATE-----EK 226

Query: 811  QEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEK 870
             +K  ++ K +   R   KEK   K  +K+   E + ++     +  +   E +  I E 
Sbjct: 227  SKK--RKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEE-IPPIPEN 283

Query: 871  DKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHL 930
              L             KS   A  K+  +RE+ RE+     + +    +R L  ++    
Sbjct: 284  RFLM-----------RKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSG-- 330

Query: 931  MEKKNKQSDNSEYSKSEKGKNKEKDR----------ELDKKEKSR----------DKESI 970
              +K K      Y    + +++++ R          E+ + ++ R          DK  +
Sbjct: 331  --RKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSEL 388

Query: 971  NITNSKHIQEEKKSSI-VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1029
            N      I+E ++S + V   K    + +S     K+E  K     + + K++DI R  E
Sbjct: 389  N-----EIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443

Query: 1030 RD-KHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKD 1088
            +D K+K+K++  +  K +S++ +        SK  R +EKR+                + 
Sbjct: 444  KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM----------------RS 487

Query: 1089 LEIEQWHKKHKEKIKQ---KEKERLRNRNCLELKIKDKEKTKHTPTESKNKE---LTRSK 1142
                + H+  KEK KQ   K K++ R+R+  + K  + +  +H  ++SK K+    +RS+
Sbjct: 488  RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547

Query: 1143 SSEVT---DAYTKEKQPKDAVSNRSQSVDTK 1170
              ++T    +Y    + +    +RS+ V ++
Sbjct: 548  ECDITKGKHSYNSRTRERSRSRDRSRRVRSR 578



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 78/380 (20%), Positives = 156/380 (41%), Gaps = 45/380 (11%)

Query: 829  KEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD-------KIKEKDKLYSHHTEKC 881
            K K  EK   K+         +  S  D    S+  D       K K++ K +  ++ K 
Sbjct: 182  KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKH 241

Query: 882  HKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE-KPEKERHLAESKEKHLMEKKNKQSDN 940
             KE +K K +   KK+   E   E ++ +     +PE+   + E++   LM K   ++D 
Sbjct: 242  KKEKKKRKKS---KKSASSESEAENLEAQPQSTVRPEEIPPIPENR--FLMRKSPPKADE 296

Query: 941  SEYSKSEKGKNKEKDRELDKKEK-----------SRDKESINITNSKHIQEEKKSSIVDG 989
             E     K + +E++RE +               +R    I     +  +   +S   D 
Sbjct: 297  KE----RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDR 352

Query: 990  NKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-DIDRYKERDKHKDKIQINSLLKLKSE 1048
             +     P   +E  + + ++   G+   K DK +++  KE  +   +++   +   ++ 
Sbjct: 353  FRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNV 412

Query: 1049 ADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
            ++ P  K+         KEK++   D    S ER +     + +    K+K K+K++ K 
Sbjct: 413  SESPNRKNE--------KEKKV--KDHKSNSKERDIRRNSEKDD----KYKNKVKKRAKS 458

Query: 1109 RLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1168
            + R+++  + K K+++ +KH   E K    +RSK  +  +   KEKQ      ++ +S  
Sbjct: 459  KSRSKSKEKSKSKERD-SKHNRNEEKRMR-SRSKGRDHENVKEKEKQSDSKGKDQERSRS 516

Query: 1169 TKNVMTLGKSSFVSDNSLNR 1188
             +    L   S   D+S ++
Sbjct: 517  KEKSKQLESKSNEHDHSKSK 536



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 74/355 (20%), Positives = 130/355 (36%), Gaps = 42/355 (11%)

Query: 355 PSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK 414
           P+  +E E K  D +  +K  D R    K+ + +N+ +          ++A      KSK
Sbjct: 416 PNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK----------KRAKSKSRSKSK 465

Query: 415 KQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKR 474
           ++  S+   S    ++E+ ++++        + E         K+     + + + K K 
Sbjct: 466 EKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKD-----QERSRSKEKS 520

Query: 475 KLKNQNKNKENQELKQEKEGKENTRITNLTVNTGL-DCSEKTREEGNFR------KSFSP 527
           K      N+ +    +EK+ +  +R     +  G    + +TRE    R      +S + 
Sbjct: 521 KQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580

Query: 528 KDDTS----LHLF----HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPD 579
             D S     H +    +   G+S          +S    +   +        E S   +
Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRN 640

Query: 580 LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT 639
             +Y N ES    +SS  K     EK  + K         S  K  D D SP       +
Sbjct: 641 KDKYRNQES----KSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSP------FS 690

Query: 640 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE 694
             K   +   LK   LK+KE EK +   E E +K K +  D   E  ++ +FD E
Sbjct: 691 KIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE--KNKKFDHE 743



 Score = 36.2 bits (82), Expect = 0.34
 Identities = 31/141 (21%), Positives = 52/141 (36%), Gaps = 6/141 (4%)

Query: 48  VSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPE 107
           + K   +K   KR    + S S + + DS +DS     S +         +   +K    
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237

Query: 108 KKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKT 167
            +K KKE   +K +  S       SE + +    Q T R   P+  P  P      +K  
Sbjct: 238 SRKHKKEKKKRKKSKKS---ASSESEAENLEAQPQSTVR---PEEIPPIPENRFLMRKSP 291

Query: 168 PSSSSRQKDKVNKRNERGETP 188
           P +  +++    +  ER   P
Sbjct: 292 PKADEKERKNRERERERECNP 312


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
            sapiens]
          Length = 1220

 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 145/664 (21%), Positives = 269/664 (40%), Gaps = 103/664 (15%)

Query: 542  KSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD----------NTESEFL 591
            + P+ S G  +K+    KQ+  +  +     E+SL+   ++ D          N E EF 
Sbjct: 35   QEPQKSKGKKKKEKK--KQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92

Query: 592  PESSSVKSCKHKEKSKHQKDFH----LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
             +    K  K K++S    D       +   K  AK K E +S + ++ D        +G
Sbjct: 93   SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152

Query: 648  KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEF--DREFWKENFFKSDE 705
            K  K +K      E E + K+I   KE+ +   S +    S EF   R+  K+N      
Sbjct: 153  KAQKSNKKWDGSEEDEDNSKKI---KERSRINSSGESGDESDEFLQSRKGQKKN------ 203

Query: 706  TEDLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEK 760
                            +K+K   NI+     DD S K K V++++  K+ER++ K++ EK
Sbjct: 204  ----------------QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247

Query: 761  SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI--EKQEKHIKES 818
            +    K++ LKE+ E     KD           EE      V  +  +    +EK    +
Sbjct: 248  A----KLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303

Query: 819  KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
              + +     K+KD +K + +  EKEK+ K +  S+     + E + K+KE+++      
Sbjct: 304  AAEDDNEGDKKKKDKKKKKGEKEEKEKE-KKKGPSKATVKAMQEALAKLKEEEERQKREE 362

Query: 879  EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK--EKHLMEKKNK 936
            E+  K  E+ +     K+ ++    +EK +RK  KEK  KER   E K   K   E + +
Sbjct: 363  EERIKRLEELE----AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418

Query: 937  QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEK 996
                 +  +++  +   KD    K+    DK+   I      +E  +S  +       E+
Sbjct: 419  AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ 478

Query: 997  PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYK--ERDKHKDKIQINSL-LKLKSEADKPK 1053
             +  KE+T   P      +E+D +D  +D ++    D+  +K++ N + +++K   ++ +
Sbjct: 479  GVPEKEET---PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535

Query: 1054 PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1113
             +     +D   +E+                     E E+   +  E  ++ E       
Sbjct: 536  EEEEEEEEDEESEEE---------------------EEEEGESEGSEGDEEDE------- 567

Query: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQS---VDTK 1170
                 K+ D++ +  T  +  +KE++     +  D  TKE++  D    R +      +K
Sbjct: 568  -----KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622

Query: 1171 NVMT 1174
            NV T
Sbjct: 623  NVNT 626



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 142/619 (22%), Positives = 259/619 (41%), Gaps = 108/619 (17%)

Query: 623  KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSA 682
            K K ED +    + D    +++  G        K +E +K K KK+ E +K+ +   D  
Sbjct: 6    KNKSEDSTKDDIDLDALAAEIEGAGAA------KEQEPQKSKGKKKKEKKKQDFDEDDIL 59

Query: 683  KELQ------RSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK----- 731
            KEL+      + ++ DRE           TE    N E E  + +KK K +K  K     
Sbjct: 60   KELEELSLEAQGIKADRE-----TVAVKPTE----NNEEEFTSKDKKKKGQKGKKQSFDD 110

Query: 732  ------DDKSTKEKHVSKER-----------NFKEERDKIKKESEKSFR--------EEK 766
                  +DK +K K  +K +           +F +   K K +++KS +        E+ 
Sbjct: 111  NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170

Query: 767  IKDLKEERENIPT-----DKDSEFTSL--------------GMSAIEESIGLHLVEKEID 807
             K +K ER  I +     D+  EF                  + +  E        K + 
Sbjct: 171  SKKIK-ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA 229

Query: 808  IEKQEKHIKESKEKPEKRSQIKE-KDIEKMER----KTFEKEKKIKHEHKSEKDKLDLSE 862
             +K EK  +E K++ E+++++++ K+ E++E     ++ +KE + K E ++ K K+ +  
Sbjct: 230  QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289

Query: 863  CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK-----------MDRKH 911
             V    E +K  +    +   EG+K K     KK +  EK +EK           M    
Sbjct: 290  GVIPASE-EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348

Query: 912  DKEKPEKERHLAESKEK----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
             K K E+ER   E +E+      +E K K+ +  E  K E+ K KEK+R    KE+ + K
Sbjct: 349  AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER----KERLK-K 403

Query: 968  ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027
            E   +T S+     +  + +   +AQ  +  S     K  P+       +DKK K I + 
Sbjct: 404  EGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPI------YEDKKRKKIPQQ 457

Query: 1028 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1087
             E  +  + +++ + +++  +    K ++ P      P+E+    +D     +E M S +
Sbjct: 458  LESKEVSESMELCAAVEVMEQGVPEKEETPP---PVEPEEEE-DTEDAGLDDWEAMASDE 513

Query: 1088 DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE-SKNKELTRSKSSEV 1146
            + E  + +K H E  +  E+E        E +  ++E+ +   +E S+  E     S E 
Sbjct: 514  ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573

Query: 1147 TDAYTKEKQPKDAVSNRSQ 1165
                T +K+P   +S+ S+
Sbjct: 574  DSGKTLDKKPSKEMSSDSE 592



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 155/658 (23%), Positives = 272/658 (41%), Gaps = 111/658 (16%)

Query: 360 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 419
           E + +D D+++I K +++  +  +  + + E  A K       E+ F  K  K K QK  
Sbjct: 47  EKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT--ENNEEEFTSKDKKKKGQKGK 104

Query: 420 RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 479
           +  +   +S + E   +K   T+   +   S SD       +     K KGK ++  K  
Sbjct: 105 KQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPK---KAKGKAQKSNKKW 161

Query: 480 NKNKENQELKQEKEGKENTRITN-----------LTVNTGLDCSEKTREEGNFRKSFSPK 528
           + ++E+++    K+ KE +RI +           L    G   ++K +   N  +S +  
Sbjct: 162 DGSEEDED--NSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI-ESGNED 218

Query: 529 DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTES 588
           DD S  +  ++  K+ K       K+    K++  K  L                     
Sbjct: 219 DDASFKIKTVAQKKAEK-------KERERKKRDEEKAKLRK------------------- 252

Query: 589 EFLPESSSVKSCKHKEKSKHQKDFHLEFGEKS-NAKIK-DEDHSPTFENS--DCTLKKMD 644
             L E   +++ K K++SK QK+   +F E++  +K+  D    P  E      T  + D
Sbjct: 253 --LKEKEELETGK-KDQSK-QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD 308

Query: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
            EG   KK K K K  ++EK K     EK+K  +K + K +Q ++   +E   E   +  
Sbjct: 309 NEGDKKKKDKKKKKGEKEEKEK-----EKKKGPSKATVKAMQEALAKLKE---EEERQKR 360

Query: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 764
           E E+    +E      +++ +LE+  ++ K  KEK   KER  KE +   K + E   R 
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE-RKERLKKEGKLLTKSQREARARA 419

Query: 765 EK-IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 823
           E  +K L+ +   +P+ KDS          +  I      K+I  + + K + ES E   
Sbjct: 420 EATLKLLQAQGVEVPS-KDS-------LPKKRPIYEDKKRKKIPQQLESKEVSESMELCA 471

Query: 824 KRSQIKEKDIEKMERKTFEKEK-----KIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
                    +E ME+   EKE+     + + E  +E   LD  E +   +E +K+  +  
Sbjct: 472 A--------VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGN-- 521

Query: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQS 938
            K H E           K +  E+  E+ + + D+E  E+E    ES+     E+  K S
Sbjct: 522 -KVHIE----------VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVS 570

Query: 939 DNSEYSKS---EKGKNKEKDRELD------KKEKSRDK-----ESINITNSKHIQEEK 982
           D  +  K+   +  K    D E D      K+E++ DK     E   + +SK++  EK
Sbjct: 571 DEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 132/644 (20%), Positives = 249/644 (38%), Gaps = 69/644 (10%)

Query: 305 PLSDDDESYTDSEE---AQSVNPSSVDENIDSETE-KDSLICESKQILPSKTPLPSALDE 360
           P  +++E +T  ++    Q     S D+N   E E KDS   +SK+    K  + S  D 
Sbjct: 83  PTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS---KSKKTAKPKVEMYSGSD- 138

Query: 361 YEFKDDDD------------EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYP 408
               DDDD            ++ NK  D         +K  E     +   +  E   + 
Sbjct: 139 ----DDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194

Query: 409 KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVS-GEHK 467
           +S K +K+        + ES +E+   + KI T      E    + + + E      + K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254

Query: 468 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTG-LDCSEKTREEGNFRKSFS 526
           +K +++   K+Q+K KE+Q     ++ +E T  + +TV+TG +  SE+  E     +  +
Sbjct: 255 EKEELETGKKDQSKQKESQ-----RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309

Query: 527 PKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMS-LQPDLVRYDN 585
             D            K  K   G  E++    K+  +K  +      ++ L+ +  R   
Sbjct: 310 EGDKKK---------KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360

Query: 586 TESEFLPESSSVKSCKHKEKS--------KHQKDFHLEFGEKSNAKIKDEDHSPTFENSD 637
            E E +     +++ + +E+         K QK+   +   K   K+  +        ++
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420

Query: 638 CTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDR--EF 695
            TLK +  +G  +       K+R   + KK     ++K   +  +KE+  S+E     E 
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKK-----RKKIPQQLESKEVSESMELCAAVEV 475

Query: 696 WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIK 755
            ++   + +ET       E E          E    D+++ K   V   +   E ++  +
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEK---VEGNKVHIEVKENPE 532

Query: 756 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 815
           +E E+   EE+ ++ +EE E     + SE         +E      ++K+   E      
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592

Query: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD--KIKEKDKL 873
            +S +   K  +  +K   ++E++  E  K +  E K     + +   VD  K K  DKL
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTE-KLRAPIICVLGHVDTGKTKILDKL 651

Query: 874 YSHHTEKCHKEGEKSKNTAAIKKTD---DREKSREKMDRKHDKE 914
              H +    +GE    T  I  T+   +    + KM +  D+E
Sbjct: 652 RHTHVQ----DGEAGGITQQIGATNVPLEAINEQTKMIKNFDRE 691



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 93/537 (17%), Positives = 204/537 (37%), Gaps = 67/537 (12%)

Query: 258 SASSGHRDIVKLLLRHGGNPFQANKH---GERPVDVAETEELELLLKREVPLSDDDESYT 314
           S S    D  KL  +  G   ++NK     E   D ++  +    +       D+ + + 
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194

Query: 315 DSEEAQSVNPSSVD-ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINK 373
            S + Q  N  +    NI+S  E D    + K +   K        E + +D++  ++ K
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER--ERKKRDEEKAKLRK 252

Query: 374 MIDDRHI--------LRKEQRKENEPEAEKTHLF-------AKQEKAFYPKSFKSKKQKP 418
           + +   +         +KE +++ E E  K+ +        A +EKA  P + +   +  
Sbjct: 253 LKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGD 312

Query: 419 SRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKN 478
            +      +  ++E  + +K         +     +   KE     + +++ ++KR  + 
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL 372

Query: 479 QNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNF----RKSFSPKDDTSLH 534
           + K KE + L+QEK  ++  +          +  E+ ++EG      ++    + + +L 
Sbjct: 373 EAKRKEEERLEQEKRERKKQK--------EKERKERLKKEGKLLTKSQREARARAEATLK 424

Query: 535 LFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 594
           L      + P     L +K+     ++  K      S E+S   +L        + +PE 
Sbjct: 425 LLQAQGVEVPSKD-SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483

Query: 595 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHK 654
                    E+ +  +D  L+                     D      D+E + ++ +K
Sbjct: 484 EETPPPVEPEEEEDTEDAGLD---------------------DWEAMASDEETEKVEGNK 522

Query: 655 LKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME 714
           +  + +E  + ++E E E+E         E + S E + E  +    + DE ++   + +
Sbjct: 523 VHIEVKENPEEEEEEEEEEE---------EDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573

Query: 715 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK---ESEKSFREEKIK 768
               TL+KK   E +   +  + +    +ER + + + +I+K   E  K+   EK++
Sbjct: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 118/647 (18%), Positives = 228/647 (35%), Gaps = 77/647 (11%)

Query: 28  RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
           +KSK K     K    +  D+ KE++E S   + +             +D ++     +E
Sbjct: 38  QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGI------------KADRETVAVKPTE 85

Query: 88  NWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARD 147
           N  E   S  +   +K+G + KK   +  + +      L       +K     ++M +  
Sbjct: 86  NNEEEFTSKDK---KKKGQKGKKQSFDDNDSEE-----LEDKDSKSKKTAKPKVEMYSGS 137

Query: 148 NSPDSTPNHPSQTT-PAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELIS 206
           +  D     P +    AQK        ++D+ N +  +  + ++ +   GD         
Sbjct: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197

Query: 207 LGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDI 266
            G   N K+  G  P  E+ N    D A   I   A    +  + +    D   +  R +
Sbjct: 198 KGQKKNQKNKPG--PNIESGNED--DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253

Query: 267 -VKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPS 325
             K  L  G       K  +R  +    +    +    +P S++      + E  +    
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313

Query: 326 SVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQ 385
              +    + EK+    E K+  PSK  +  A+ E   K  ++EE  K  ++  I R E+
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKK-GPSKATV-KAMQEALAKLKEEEERQKREEEERIKRLEE 371

Query: 386 RKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
            +    E E+     ++ K    K  K + +K  ++L  S   +   A    K+  +  V
Sbjct: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431

Query: 446 IPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQEL-------------KQEK 492
             E  + D   KK  +   E K++ K+ ++L+++  + E+ EL             K+E 
Sbjct: 432 --EVPSKDSLPKKRPIY--EDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486

Query: 493 EGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSE 552
                      T + GLD  E    +    K    K        HI   ++P+      E
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK-------VHIEVKENPEEEEEEEE 539

Query: 553 KQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDF 612
           ++    + E                         E E   ES   +  +  EK   +KD 
Sbjct: 540 EEEEDEESEE------------------------EEEEEGESEGSEGDEEDEKVSDEKDS 575

Query: 613 HLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
                +K + ++  +    + ++     +  DK  + ++K +L+H +
Sbjct: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)

Query: 276  NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 335
            NP  +N   E    V E ++L + ++++   +  D S  D+ +   +  S   E +D  +
Sbjct: 633  NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 691

Query: 336  EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 395
            + D ++   K++        S +      D D  EI+      + L+ +  K+++ + ++
Sbjct: 692  DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 743

Query: 396  THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 452
                +  +  F  K  KS K      +   + +ESS+ ++   K+I +   +    T+  
Sbjct: 744  KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 801

Query: 453  DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 503
             +   K++  S +  H +KG   +  KN    Q  + ++ E KQE+E     E T   + 
Sbjct: 802  RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 861

Query: 504  TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 548
            T+    D   K ++     +G  + S   +  TSL +           H+ T    K   
Sbjct: 862  TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 921

Query: 549  GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 591
            GLS+     LK++ +       K     G+ E     D  +        Y+++   +E L
Sbjct: 922  GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981

Query: 592  PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
            PE   +                   KS K ++K+  +KD   ++ EKS  K    D S  
Sbjct: 982  PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1041

Query: 633  FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 675
             ++ +    +  K  K L K   K ++                   +K  K IE  E+  
Sbjct: 1042 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1101

Query: 676  YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 729
              +K + KE+Q                SD  E    N + +  T  KK       K   +
Sbjct: 1102 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1150

Query: 730  IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 788
            ++     K+  ++   +   E D      E S  E+KIK + E   N+     + F  S 
Sbjct: 1151 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1207

Query: 789  GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 824
            G  A+ +S+ + + + + D + + +  K                        E K++  K
Sbjct: 1208 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1267

Query: 825  RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
            +++    D E   +   E +      KK ++ H+  + KL +S+     ++K K   H  
Sbjct: 1268 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327

Query: 879  EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
             K     K   +    +  +++   E+  E  D +  + +  K+  L E++  +  +KK 
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1387

Query: 936  KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
            ++    E S SE   N E++ E  ++E+  ++E          +EE++    D +K+  +
Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1437

Query: 996  KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
                +++  KD+ L+T       ++++   R  ER++ ++K      L+   E +   P 
Sbjct: 1438 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1491

Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1092
              P +      E     + L+Q     ++ LK  +++
Sbjct: 1492 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1528



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)

Query: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
            ++K  KL +   +  S+  K + +  +  E     K    K+F+   + D+K+    +  
Sbjct: 315  IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 373

Query: 780  DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 839
            D +SEF ++     E++   H   K ID + + K       K EK   +++KDI K E K
Sbjct: 374  DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 425

Query: 840  TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 896
               K+   +H H+   +E+ + + S   +  K+ D+      E  +   +   +  ++  
Sbjct: 426  LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 484

Query: 897  T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 942
            +      ++ E + E    +D + D     ++   + S + ++  K N+    S+     
Sbjct: 485  SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 544

Query: 943  ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 981
                Y K +    +    +  D +E  +DK+                    ++++H+ E 
Sbjct: 545  TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604

Query: 982  KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1041
            + S +++      E  L    + K  PL+ P        + D +   E  K K K+ +  
Sbjct: 605  EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 657

Query: 1042 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1092
              K K     S  D PKP   P SK +   ++   +D+++    + S     S  D +I 
Sbjct: 658  RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 717

Query: 1093 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1144
            + H  HK     K      +K + + ++       D +K K   +   SK K  T+S+SS
Sbjct: 718  EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 777

Query: 1145 EVTDAYTKE 1153
                   KE
Sbjct: 778  NYDSELEKE 786



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)

Query: 744  ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 801
            E+  ++ + KIK +SEKS +  E   +   ++  +    ++ +       ++  S    +
Sbjct: 250  EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 309

Query: 802  VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 856
            V KE+ I+K +K I+ +        +  ++  +  E  +  K +++K   KS     +K 
Sbjct: 310  VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 367

Query: 857  KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 907
             L L E ++ + +  D +      K HK        +  K +   A++K D   KS  K+
Sbjct: 368  HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 426

Query: 908  DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 965
             RK  D E   +     E +       ++K+SD  E  + E   N  +D ++D     S 
Sbjct: 427  SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 485

Query: 966  DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 1004
              E I  N+  +  +Q              +E +SS V  N +  +    +K KT     
Sbjct: 486  VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 545

Query: 1005 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1037
                         + P+K  D +E   +DKD               + +    ++H  + 
Sbjct: 546  KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 604

Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1096
            +++ LL+       P+ K++P     RP E   V  +  +   E +   + L +    K 
Sbjct: 605  EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 661

Query: 1097 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1143
                        K  +  K K+ E + +N +  E+    KE ++ + + S + ++    +
Sbjct: 662  KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 721

Query: 1144 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
            +  T    K +  KD    R +         DTK   +  KSS +S         S N  
Sbjct: 722  NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 780

Query: 1197 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1255
              L     SM  + ++        T  R P   D D   +   S+         ++  S 
Sbjct: 781  SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 834

Query: 1256 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1303
                       ERE  S A+     +       +RL      S+S + V  +  + +   
Sbjct: 835  EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894

Query: 1304 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1363
            ++EVR+ +      E +K  +T + +  Q  L                S++ E+ L    
Sbjct: 895  SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 933

Query: 1364 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1421
                S  TS      SK  + ++                   +PS   +  +   + +E 
Sbjct: 934  --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 973

Query: 1422 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1473
              D  E L  R+ IC   + P     +++      K  K+  D  S ++ EL        
Sbjct: 974  SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1030

Query: 1474 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1526
              G+SC  ++D  S    +   ++ C    +S    +  S   +  Y + +E G      
Sbjct: 1031 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1089

Query: 1527 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1586
             ++ I      +  S ++T+   +      +DA      +   ++ + + +KA    V+ 
Sbjct: 1090 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1143

Query: 1587 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1643
             EK  N    ST+       + +T  SSS  E ++  +  +  S E++ K   E+LVL +
Sbjct: 1144 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1199

Query: 1644 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1703
            H   C S   E  +      +++ D  + PE+      I  +   + I ++L +    S+
Sbjct: 1200 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1254

Query: 1704 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1763
              E  +  +    + EEN  D++ +NQ+      +++++ + +SK+      LL  K + 
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1309

Query: 1764 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1790
            S    G  + T+  +  ++    +RKVS
Sbjct: 1310 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1337



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 80/399 (20%), Positives = 143/399 (35%), Gaps = 52/399 (13%)

Query: 28   RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
            R +K+  +  S +   E S+ +K+ K+++S K+K        RN  R S        TS 
Sbjct: 1106 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1165

Query: 88   NWGERLISSYRTYSEKEGPEKK-----------------KTKKEAGNKKSTPVSI----L 126
            +  +       +  E    E+K                 ++  +    KS PV++     
Sbjct: 1166 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1225

Query: 127  FGYPLSERKQMALLMQMTA-----RDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKR 181
               P +   +  LL ++ A      D S D  P    + T  Q +        K++VN  
Sbjct: 1226 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1285

Query: 182  NERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI--A 239
            ++           R  + + K  +S G +   K     T   E   V   +  K+    +
Sbjct: 1286 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK----TKPKEHKEVKGRNRRKVSSEDS 1341

Query: 240  AGADVNTQGLDDD-TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL 298
              +D    G+ ++ +   D      R   K  L      ++  K   R + V E    E 
Sbjct: 1342 EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK-RRRIKVQEDSSSEN 1400

Query: 299  LLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET-----EKDSLICESKQILPSKTP 353
                E    +++E   + EE +       DEN DS++     +K   I +  ++   +T 
Sbjct: 1401 KSNSE---EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL---RTE 1454

Query: 354  LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
              +AL E       +EE  K I +R   R++ R+  E E
Sbjct: 1455 TQNALKE-------EEERRKRIAEREREREKLREVIEIE 1486


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 180/937 (19%), Positives = 359/937 (38%), Gaps = 161/937 (17%)

Query: 276  NPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET 335
            NP  +N   E    V E ++L + ++++   +  D S  D+ +   +  S   E +D  +
Sbjct: 671  NPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSD-SAIDNPKPNKLPKSKQSETVDQNS 729

Query: 336  EKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEK 395
            + D ++   K++        S +      D D  EI+      + L+ +  K+++ + ++
Sbjct: 730  DSDEMLAILKEV--------SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR 781

Query: 396  THLFAKQEKAFYPKSFKSKKQK--PSRVLYSSTESSDEEALQNKKISTSCSV-IPETSNS 452
                +  +  F  K  KS K      +   + +ESS+ ++   K+I +   +    T+  
Sbjct: 782  KSSTSGSD--FDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 839

Query: 453  DMQTKKEYVVSGE--HKQKGKVKRKLKN----QNKNKENQELKQEKE---GKENTRITNL 503
             +   K++  S +  H +KG   +  KN    Q  + ++ E KQE+E     E T   + 
Sbjct: 840  RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT 899

Query: 504  TVNTGLDCSEKTRE-----EGNFRKSFSPKDDTSLHLF----------HISTGKSPKHSC 548
            T+    D   K ++     +G  + S   +  TSL +           H+ T    K   
Sbjct: 900  TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 959

Query: 549  GLSEKQSTPLKQEHT-------KTCLSPGSSEMSLQPDLVR--------YDNTE--SEFL 591
            GLS+     LK++ +       K     G+ E     D  +        Y+++   +E L
Sbjct: 960  GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019

Query: 592  PESSSV-------------------KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPT 632
            PE   +                   KS K ++K+  +KD   ++ EKS  K    D S  
Sbjct: 1020 PEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED 1079

Query: 633  FENSDCTLKKMDKEGKTLKKHKLKHKE----------------REKEKHKKEIE-GEKEK 675
             ++ +    +  K  K L K   K ++                   +K  K IE  E+  
Sbjct: 1080 KKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN 1139

Query: 676  YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKS------KLEKN 729
              +K + KE+Q                SD  E    N + +  T  KK       K   +
Sbjct: 1140 LSSKRNTKEIQSGSS-----------SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNS 1188

Query: 730  IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFT-SL 788
            ++     K+  ++   +   E D      E S  E+KIK + E   N+     + F  S 
Sbjct: 1189 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE---NLVLSSHTGFCQSS 1245

Query: 789  GMSAIEESIGLHLVEKEIDIEKQEKHIK------------------------ESKEKPEK 824
            G  A+ +S+ + + + + D + + +  K                        E K++  K
Sbjct: 1246 GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK 1305

Query: 825  RSQIKEKDIEKMERKTFEKE------KKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHT 878
            +++    D E   +   E +      KK ++ H+  + KL +S+     ++K K   H  
Sbjct: 1306 QNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365

Query: 879  EK---CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
             K     K   +    +  +++   E+  E  D +  + +  K+  L E++  +  +KK 
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1425

Query: 936  KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
            ++    E S SE   N E++ E  ++E+  ++E          +EE++    D +K+  +
Sbjct: 1426 RRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE----------EEEEEEDENDDSKSPGK 1475

Query: 996  KPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
                +++  KD+ L+T       ++++   R  ER++ ++K      L+   E +   P 
Sbjct: 1476 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK------LREVIEIEDASPT 1529

Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIE 1092
              P +      E     + L+Q     ++ LK  +++
Sbjct: 1530 KCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVD 1566



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 98/489 (20%), Positives = 191/489 (39%), Gaps = 72/489 (14%)

Query: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
            ++K  KL +   +  S+  K + +  +  E     K    K+F+   + D+K+    +  
Sbjct: 353  IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSV-LADIKKAHLALEE 411

Query: 780  DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 839
            D +SEF ++     E++   H   K ID + + K       K EK   +++KDI K E K
Sbjct: 412  DLNSEFRAMDAVNKEKNTKEH---KVIDAKFETK-----ARKGEKPCALEKKDISKSEAK 463

Query: 840  TFEKEKKIKHEHK---SEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK 896
               K+   +H H+   +E+ + + S   +  K+ D+      E  +   +   +  ++  
Sbjct: 464  LSRKQVDSEHMHQNVPTEEQRTNKSTGGEH-KKSDRKEEPQYEPANTSEDLDMDIVSVPS 522

Query: 897  T------DDREKSRE---KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE----- 942
            +      ++ E + E    +D + D     ++   + S + ++  K N+    S+     
Sbjct: 523  SVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKV 582

Query: 943  ----YSK-SEKGKNKEKDRELDKKEKSRDKESINI----------------TNSKHIQEE 981
                Y K +    +    +  D +E  +DK+                    ++++H+ E 
Sbjct: 583  TKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642

Query: 982  KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINS 1041
            + S +++      E  L    + K  PL+ P        + D +   E  K K K+ +  
Sbjct: 643  EVSLLLE------ESDLRRSPRVKTTPLRRPTETNPVTSNSD-EECNETVKEKQKLSVPV 695

Query: 1042 LLKLK-----SEADKPKPKSSPASKDTRPKEKRLVNDDLM----QTSFERMLSLKDLEIE 1092
              K K     S  D PKP   P SK +   ++   +D+++    + S     S  D +I 
Sbjct: 696  RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDIN 755

Query: 1093 QWHKKHKEKIKQK------EKERLRNRNCLELKIKDKEKTKHTPTE--SKNKELTRSKSS 1144
            + H  HK     K      +K + + ++       D +K K   +   SK K  T+S+SS
Sbjct: 756  EIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESS 815

Query: 1145 EVTDAYTKE 1153
                   KE
Sbjct: 816  NYDSELEKE 824



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 224/1168 (19%), Positives = 434/1168 (37%), Gaps = 201/1168 (17%)

Query: 744  ERNFKEERDKIKKESEKSFR--EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHL 801
            E+  ++ + KIK +SEKS +  E   +   ++  +    ++ +       ++  S    +
Sbjct: 288  EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALI 347

Query: 802  VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKS-----EKD 856
            V KE+ I+K +K I+ +        +  ++  +  E  +  K +++K   KS     +K 
Sbjct: 348  VPKEM-IKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK-AFKSVLADIKKA 405

Query: 857  KLDLSECVD-KIKEKDKLYSHHTEKCHK--------EGEKSKNTAAIKKTDDREKSREKM 907
             L L E ++ + +  D +      K HK        +  K +   A++K D   KS  K+
Sbjct: 406  HLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDI-SKSEAKL 464

Query: 908  DRKH-DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELD-KKEKSR 965
             RK  D E   +     E +       ++K+SD  E  + E   N  +D ++D     S 
Sbjct: 465  SRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA-NTSEDLDMDIVSVPSS 523

Query: 966  DKESI--NITNSKHIQ--------------EEKKSSIVDGNKAQHEKPLSLKEKT----- 1004
              E I  N+  +  +Q              +E +SS V  N +  +    +K KT     
Sbjct: 524  VPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVT 583

Query: 1005 ------------KDEPLKTPDGKEKDKKDKD---------------IDRYKERDKHKDKI 1037
                         + P+K  D +E   +DKD               + +    ++H  + 
Sbjct: 584  KELYVKLTPVSLSNSPIKGADCQEV-PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN 642

Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHK- 1096
            +++ LL+       P+ K++P     RP E   V  +  +   E +   + L +    K 
Sbjct: 643  EVSLLLEESDLRRSPRVKTTPL---RRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKD 699

Query: 1097 ------------KHKEKIKQKEKERL-RNRNCLELKIKDKEKTKHTPTESKNKELTRSKS 1143
                        K  +  K K+ E + +N +  E+    KE ++ + + S + ++    +
Sbjct: 700  KRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHT 759

Query: 1144 SEVTDAYTKEKQPKDAVSNRSQ-------SVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
            +  T    K +  KD    R +         DTK   +  KSS +S         S N  
Sbjct: 760  NHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS-AKSSIISKKKRQTQSESSNYD 818

Query: 1197 PGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKS- 1255
              L     SM  + ++        T  R P   D D   +   S+         ++  S 
Sbjct: 819  SELEKEIKSMSKIGAAR------TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 872

Query: 1256 -------PALHERELDSLAD---LPERIKPPYANRLSTSHLRSSSVEDVKLIISEGR--P 1303
                       ERE  S A+     +       +RL      S+S + V  +  + +   
Sbjct: 873  EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932

Query: 1304 TIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVS 1363
            ++EVR+ +      E +K  +T + +  Q  L                S++ E+ L    
Sbjct: 933  SLEVRKVAETK---EKSKHLKTKTCKKVQDGL----------------SDIAEKFLKK-- 971

Query: 1364 NIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPS--SQVGVIQNKSWEM 1421
                S  TS      SK  + ++                   +PS   +  +   + +E 
Sbjct: 972  --DQSDETSEDDKKQSKKGTEEKK------------------KPSDFKKKVIKMEQQYES 1011

Query: 1422 PVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTEL-------- 1473
              D  E L  R+ IC   + P     +++      K  K+  D  S ++ EL        
Sbjct: 1012 SSDGTEKLPEREEIC---HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1068

Query: 1474 -PGNSC--AQDPAS----FMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKN 1526
              G+SC  ++D  S    +   ++ C    +S    +  S   +  Y + +E G      
Sbjct: 1069 GKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKY-SMKEDGCNSSDK 1127

Query: 1527 AVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLP 1586
             ++ I      +  S ++T+   +      +DA      +   ++ + + +KA    V+ 
Sbjct: 1128 RLKRIELRERRNLSSKRNTKE--IQSGSSSSDAEESSEDNKKKKQRTSSKKKA----VIV 1181

Query: 1587 SEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENK--LESLVL-T 1643
             EK  N    ST+       + +T  SSS  E ++  +  +  S E++ K   E+LVL +
Sbjct: 1182 KEKKRNSLRTSTKRKQ----ADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSS 1237

Query: 1644 HLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQST 1703
            H   C S   E  +      +++ D  + PE+      I  +   + I ++L +    S+
Sbjct: 1238 HTGFCQSSGDEALSKSVPVTVDDDDDDNDPENR-----IAKKMLLEEIKANLSSDEDGSS 1292

Query: 1704 QPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSE 1763
              E  +  +    + EEN  D++ +NQ+      +++++ + +SK+      LL  K + 
Sbjct: 1293 DDEPEEGKKRTGKQNEENPGDEEAKNQV-----NSESDSDSEESKKPRYRHRLLRHKLTV 1347

Query: 1764 SSSPRGRIRLTE-DDDPQIHHPRKRKVS 1790
            S    G  + T+  +  ++    +RKVS
Sbjct: 1348 SDGESGEEKKTKPKEHKEVKGRNRRKVS 1375



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 80/399 (20%), Positives = 143/399 (35%), Gaps = 52/399 (13%)

Query: 28   RKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSE 87
            R +K+  +  S +   E S+ +K+ K+++S K+K        RN  R S        TS 
Sbjct: 1144 RNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSS 1203

Query: 88   NWGERLISSYRTYSEKEGPEKK-----------------KTKKEAGNKKSTPVSI----L 126
            +  +       +  E    E+K                 ++  +    KS PV++     
Sbjct: 1204 SSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDD 1263

Query: 127  FGYPLSERKQMALLMQMTA-----RDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKR 181
               P +   +  LL ++ A      D S D  P    + T  Q +        K++VN  
Sbjct: 1264 DNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE 1323

Query: 182  NERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI--A 239
            ++           R  + + K  +S G +   K     T   E   V   +  K+    +
Sbjct: 1324 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK----TKPKEHKEVKGRNRRKVSSEDS 1379

Query: 240  AGADVNTQGLDDD-TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELEL 298
              +D    G+ ++ +   D      R   K  L      ++  K   R + V E    E 
Sbjct: 1380 EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKK-RRRIKVQEDSSSEN 1438

Query: 299  LLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSET-----EKDSLICESKQILPSKTP 353
                E    +++E   + EE +       DEN DS++     +K   I +  ++   +T 
Sbjct: 1439 KSNSE---EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL---RTE 1492

Query: 354  LPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
              +AL E       +EE  K I +R   R++ R+  E E
Sbjct: 1493 TQNALKE-------EEERRKRIAEREREREKLREVIEIE 1524


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 176/857 (20%), Positives = 343/857 (40%), Gaps = 173/857 (20%)

Query: 424  SSTESSD---EEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEH-----KQKGKVKRK 475
            S TE++    EEA    + S+S SVI  + + D Q K    +S +H     K+  K++ K
Sbjct: 1122 SGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKD---ISKDHIALTLKRLQKIRDK 1178

Query: 476  LKNQNKNKENQELKQEKEGKENTRITNLTVNTGLD--CSEKTREEGNFRKSFSPKDDTS- 532
             +++    +  + K +K+GKE   I   T    ++   ++K + +G      S +  T+ 
Sbjct: 1179 -RDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAG 1237

Query: 533  -----------LHLFHISTGKSPKHS----------------------------CGLSEK 553
                       L    IS G   K S                            C L +K
Sbjct: 1238 DGSSWRDDLCRLMALRIS-GSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKK 1296

Query: 554  QSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFH 613
            +S  L ++     + P    + +Q   +R D      + +  + +  +HKE    ++   
Sbjct: 1297 ESKVLLEDLDWDVVPPEKKPIFIQEGAIRED------MIQGVTQEVIRHKEVMPREE--- 1347

Query: 614  LEFGEKSNAKIKDEDHSPTFENSDCTLKKMDK-----EGKTLKKHKLKHKEREKEKHKKE 668
                E++  K +D       E +   LKK  K      G      ++  KE +K   K  
Sbjct: 1348 ----EQAQKKARD---MLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSP 1400

Query: 669  IEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDL------FLNMEHESLTLEK 722
             +G K   K +   K         RE  KE    S+E E++       +  E + + +E+
Sbjct: 1401 KQGRKAVQKERKVGK-------IKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453

Query: 723  KSKLEKNIKDDKSTKEKHVSKERNFK-----------EERDKIKKESEKSFREEKI---- 767
                +   K     K+ H    +++K           +E +K+ +  EK   EE++    
Sbjct: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513

Query: 768  KDLKEER-----ENIPTDKDSE--FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKES-- 818
            K LK E      EN+ + K  E  +       +EE +     EKE  + ++++HI+E   
Sbjct: 1514 KKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHK 1573

Query: 819  -------KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEH--------KSEKDKLDLSEC 863
                   + + EK+   +E+ + + E K  ++E+++  E         K  +D  ++++ 
Sbjct: 1574 WARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQA 1633

Query: 864  VDKIKEKDKLYSHHTEKCHKEGEK--SKNTAAIKKTDDREKSREKMDRKHDK-------- 913
              K  +K++  +   EK  +E EK   K     KK +   +  EK+ +K  K        
Sbjct: 1634 EGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNIL 1693

Query: 914  -----EKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
                 E P++E++L   +++   E +  + D  E S  E+  N+E+ + +++K+K  ++E
Sbjct: 1694 AQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE 1753

Query: 969  SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTK--DEPLKTPDGKEK-DKKDKDID 1025
                   + + EE+        K   E+ L ++EK K      K P+ +E+  +K + + 
Sbjct: 1754 EALAWQREKLSEEE-------TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI 1806

Query: 1026 RYKERDKHKDKIQINSLLKL----------KSEADKPKPKSSPASKDTRPKEKRLVNDDL 1075
              K +   K +  INS+ +L          K+ A + K  +    K  + KE  L N + 
Sbjct: 1807 EKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKER 1866

Query: 1076 MQTSFERMLSLKD---------LEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
            +  S ++++ +K+          ++E+   + KE +  K+KE+L       ++++D    
Sbjct: 1867 LTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETV-IKKKEKLAETEKKLVQVEDSLAK 1925

Query: 1127 KHTPTESKNKELTRSKS 1143
            K      +  +L   K+
Sbjct: 1926 KQEKLAQEKMKLALEKA 1942



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 149/756 (19%), Positives = 305/756 (40%), Gaps = 104/756 (13%)

Query: 318  EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDD-DEEINKMID 376
            E +++    V+E    E   D    + K++      L   ++E  +K+++ ++E  K+++
Sbjct: 1688 EVKNILAQKVEELPQREQNLD---WQEKELAQELEELEWDMEELSWKEEELNQEEGKLVE 1744

Query: 377  DRHILRKEQRK---ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEA 433
            ++  L +E+     + E  +E+    A++E+    +  K  + K              E 
Sbjct: 1745 EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQ 1804

Query: 434  LQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKV----KRKLKNQNKN--KENQE 487
            L  KK+  +            Q ++ ++ S E   K K+    K+ L  + KN  +E ++
Sbjct: 1805 LIEKKMKLA------------QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852

Query: 488  LKQEKEGK--ENTRITN-----LTVNTGLDCSEK---------TREEGNFRKSFSPKDDT 531
            L Q KE       R+T+     + V   L    K         T+E+    K      +T
Sbjct: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912

Query: 532  SLHLFHISTGKSPKHSCGLSEKQSTPLKQ------EHTKTCLSPGSSEMSLQPDLVRYDN 585
               L  +    + K      EK    L++      +  +  L     E +L  ++ R   
Sbjct: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAE 1972

Query: 586  TESEFLPESSSVKSCKHKEKSKHQKDFHLE---FGEKSNAKIK---DEDHSPTFENSDCT 639
             +   +    ++   +  E S+ +K   +E   F  K + + K    ED     E S+  
Sbjct: 1973 EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIA 2032

Query: 640  LKKMD--KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWK 697
              K++  +  +   + + K  +  ++  KK     KE  K     K LQ+    +R+  +
Sbjct: 2033 KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ 2092

Query: 698  ENFFKSDETEDLF-----LNMEHESLTLEKKSKLEKN---IKDDKSTKEKH--------- 740
            E    +     LF     L++E   L +++    EK     KD+K    K          
Sbjct: 2093 EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRR 2152

Query: 741  -VSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT--------------DKDSEF 785
             ++KE    EE  K+ ++  +   +++ +   EE E IP               DK  E 
Sbjct: 2153 MINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEK 2212

Query: 786  TSLGMSAIE---------ESIGLHLVEKEIDI---EKQEKHIKESKEKPEKRSQIKE-KD 832
             S  +  +E         ES+ L  +EK+  +   E++E+  +E +E+ E R + +E K+
Sbjct: 2213 FSSQVDEVESEEHFSEEMESL-LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKE 2271

Query: 833  IEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
             E+ E K  EKE++ K + K EK K ++ E  +  +EK+++ S    +   + E+ + + 
Sbjct: 2272 EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESC 2331

Query: 893  AIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNK 952
            ++++  DREK   K +++   +  E+ R     +E+ L   +          +    K+ 
Sbjct: 2332 SLEEEVDREKEILKKEKQFKLQ--EQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSP 2389

Query: 953  EKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVD 988
             K + +    + ++K  + +   +   E+KK+++V+
Sbjct: 2390 LK-KLMSTALEMKEKTPVPVPEKQISWEDKKATVVE 2424



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 179/891 (20%), Positives = 354/891 (39%), Gaps = 138/891 (15%)

Query: 382  RKEQRKENEPEAEKTH-----LFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQN 436
            ++E  K    E EK H     L  ++E     K  K ++ K       S++S +++    
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541

Query: 437  KKISTSCSVIPETSNSDMQ-TKKEYVVSGEHKQKGKVKRKLKNQNKN-KENQELKQEKE- 493
            ++++    V  E    + Q T+++  +  EHK     +++ + + K  +E ++L QE+E 
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601

Query: 494  --------GKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK 545
                     +E  ++    V    D  E  + EG F +    K++T              
Sbjct: 1602 LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ----KEETLA------------ 1645

Query: 546  HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH--- 602
                   ++   L QE  K           L     +    E +   +   +   K+   
Sbjct: 1646 -------QRGEKLSQEAEKLA----QKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA 1694

Query: 603  -KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKERE 661
             K +   Q++ +L++ EK  A+  +E      E S    +   +EGK +++ K   +E E
Sbjct: 1695 QKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEE 1754

Query: 662  KEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLE 721
                ++E   E+E    ++    +Q     ++E   ++  K  E E+  L  + E L +E
Sbjct: 1755 ALAWQREKLSEEETKLAQEEELLIQ-----EKEKLAQHKEKMPEEEER-LGRKREQL-IE 1807

Query: 722  KKSKLEK------NIKDDKSTKEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEER 774
            KK KL +      N  ++ +  +  + +++N  +E+  + +E EK + R+E +   KE  
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867

Query: 775  ENIPTDKDSEFTSLGM-----SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
             +           LGM     + +EE +     EKE  I+K+EK       + EK+    
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKL---TQEKETVIKKKEK-----LAETEKKLVQV 1919

Query: 830  EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
            E  + K + K  +++ K+  E    + K  L   +D  KE+  L         ++    +
Sbjct: 1920 EDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979

Query: 890  NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYS 944
                + K +  E SR++   + ++E  E++  L E    H      ME+        E++
Sbjct: 1980 GKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT 2039

Query: 945  KSEK----GKNK--EKDRELDKKEKSRDKESINITN-----SKHIQEEKKSSIVDGNKAQ 993
            + ++    G+ K  +  R+L KK +S  KE   +        K  ++E+K +  +    +
Sbjct: 2040 RGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099

Query: 994  HEKPLSLKEKTKDEPLKTPDGKEKD---------KKDKDIDRYKERDKHKDKIQINSLLK 1044
             ++ L +KE+         D KE D         K +K + R + +  +K +  IN   K
Sbjct: 2100 MKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK 2159

Query: 1045 LKSEADKPKPKSSP-----------------------------ASKDTRPKEKRLVNDDL 1075
            +  E  K   K S                              A +  +PKEK     D 
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219

Query: 1076 MQTS---FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1132
            +++     E M SL D E+E+      E+ +++E+E  R     E +++++E+ +    E
Sbjct: 2220 VESEEHFSEEMESLLD-ELEKQESLSSEEEEEREEEEERE----EEEVREEEEERKEEEE 2274

Query: 1133 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSD 1183
             + K++   K  E      KEK+ ++         + + +M+  ++  +SD
Sbjct: 2275 GEEKQV--EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD 2323



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 179/924 (19%), Positives = 377/924 (40%), Gaps = 114/924 (12%)

Query: 294  EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTP 353
            +E E L +    LS ++E   + ++ +      V EN+ S   K+    + +++    T 
Sbjct: 1491 QEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEV----TL 1546

Query: 354  LPSALDEYEFKDDDDEEINKMIDDRH----ILRKEQRKENEPEAEKTHLFAKQEK-AFYP 408
                  E E K+    E  + I + H    I RK  R E +   E+  L  ++EK A   
Sbjct: 1547 EEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE 1606

Query: 409  KSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
            +    +++K ++     T+   E A    K +     + +             +S E ++
Sbjct: 1607 RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEK---------LSQEAEK 1657

Query: 469  KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPK 528
              + ++KL  + +    +E K  K+G +   + N+      +  ++ +      K  + +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717

Query: 529  -DDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNT- 586
             ++    +  +S  +   +      ++   L +E  K  L+     ++ Q + +  + T 
Sbjct: 1718 LEELEWDMEELSWKEEELN------QEEGKLVEEKKK--LAEEEEALAWQREKLSEEETK 1769

Query: 587  ---ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 643
               E E L +    K  +HKEK   +++     G K    I  E      +  +  +  M
Sbjct: 1770 LAQEEELLIQEKE-KLAQHKEKMPEEEE---RLGRKREQLI--EKKMKLAQKRERWINSM 1823

Query: 644  DKEGKTLKKHKL-KHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDRE---FWKEN 699
            ++    L K+K+  ++++   + KK +  EKEK   +      + ++ +++E     K+ 
Sbjct: 1824 EE----LTKNKMILYQKKNLAQEKKNLAQEKEKLAQR------KENLLYNKERLTHSKKQ 1873

Query: 700  FFKSDETEDLF---LNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKK 756
              +      +F   L    E LT EK++ ++K  K  + T++K V  E +  ++++K+ +
Sbjct: 1874 LVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE-TEKKLVQVEDSLAKKQEKLAQ 1932

Query: 757  ESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI 815
            E  K +  +  ++  K  R  +   K+ +  +L M  + E   + LVE +  + K E   
Sbjct: 1933 EKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEE-KMRLVEGKETLSKGET-- 1989

Query: 816  KESKEKPEKRSQIKEKDIEK--MERKTFEKEKKIKHEHK------SE--KDKLDLSECVD 865
                  PE   Q K   +E+   ERK   +EK + HE +      SE  K KL+ +    
Sbjct: 1990 ------PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQR 2043

Query: 866  KIKEKDKLYSHHTEKCHKEGEK-SKNTAAIKKT---------DDREKSREKMDR-KHDKE 914
               +  +  +  + K  K+ E  SK  A + K          D+R+ ++E++   K  + 
Sbjct: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103

Query: 915  KPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITN 974
               KER L+  + K  +++ +     SE +K EK K   K R+L  K +    +   +T 
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK-KLARKQRKLANKMRRMINKEEKMTE 2162

Query: 975  SKHIQEEKKSSIV-----DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKE 1029
             +     K S ++     +G   + E    LK + +         K K+K    +D  + 
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222

Query: 1030 RDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDL 1089
             +   ++++      L  E +K +  SS   ++   +E+R                 ++ 
Sbjct: 2223 EEHFSEEME-----SLLDELEKQESLSSEEEEEREEEEER-----------------EEE 2260

Query: 1090 EIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA 1149
            E+ +  ++ KE+ + +EK+  +     + K K+K+K +    E   +E     S E T++
Sbjct: 2261 EVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320

Query: 1150 YTKEKQPKDAVSNRSQSVDTKNVM 1173
             + E++ +++ S   +    K ++
Sbjct: 2321 LSDEEEEEESCSLEEEVDREKEIL 2344



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 157/730 (21%), Positives = 296/730 (40%), Gaps = 152/730 (20%)

Query: 571  SSEMSLQPDLVRYDNTESEFLP---ESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDE 627
            S +MS +P L+  D + +E  P   E +SV S      S  +    ++  EK  +K    
Sbjct: 1108 SKQMSTEPGLLE-DESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISK---- 1162

Query: 628  DHSPTFENSDCTLKKM----DKEGKTLKKHKLKHKEREKEKHKKEIEGE-----KEKYKT 678
            DH         TLK++    DK  K     KLK K ++K K  K I  E      E+  T
Sbjct: 1163 DHIAL------TLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVT 1216

Query: 679  KD--------SAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNI 730
            K         S    +RS   D   W+++  +      + L +      + +    E   
Sbjct: 1217 KKVKIQGRGASGISGRRSTAGDGSSWRDDLCRL-----MALRISGSQTKMSENLNAELVT 1271

Query: 731  KDDKSTKEKHVSKERNFKEERDKIKKES----------------------EKSFREEKIK 768
               +   ++H S E  F+E    +KKES                      E + RE+ I+
Sbjct: 1272 FAQEMLVDRHPSWEL-FQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQ 1330

Query: 769  DLKEE----RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHI--------- 815
             + +E    +E +P +++            + +GL   E ++ ++K +K I         
Sbjct: 1331 GVTQEVIRHKEVMPREEEQ-----AQKKARDMLGLE--ETQVILKKGKKVIFLEPGNVTM 1383

Query: 816  -KESKEKPEKRSQIKEKDIEKMERKTFEKEKKI-KHEHKSEKDKLDLSECVDK------- 866
             KE  +K EK++  K     K  RK  +KE+K+ K + +  K++ D+SE V++       
Sbjct: 1384 GKEISKKEEKKTFQKS---PKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440

Query: 867  -IKEKDKLYSHHTEKCHKE------------GEKSKNTAAIKKTDDRE--KSREKMDRKH 911
             +K++ KL         ++            GE  K+  A K+  ++   +  EK+ +  
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500

Query: 912  DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSR---DKE 968
            +K  PE+E  + +  +K   E+  +  +N   SKS++ + K+++    ++E SR   +KE
Sbjct: 1501 EKLSPEEE--MLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE 1558

Query: 969  SINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK---TKDEPLKTPDGK--EKDKK--- 1020
                   +HIQEE K + +   +A+ EK  + +E+    ++E L   + +  ++++K   
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618

Query: 1021 --------DKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASK---DTRPKEKR 1069
                    D+++ + + +   K++       KL  EA+K   K    +K       +E++
Sbjct: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678

Query: 1070 LVNDDLMQTSFERMLSLKDLEIEQ------WHKKH-----------KEKIKQKEKERLRN 1112
            L          + +L+ K  E+ Q      W +K             E++  KE+E  + 
Sbjct: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738

Query: 1113 RNCL---ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEK--QPKDAVSNRSQSV 1167
               L   + K+ ++E+      E  ++E T+    E      KEK  Q K+ +    + +
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798

Query: 1168 DTKNVMTLGK 1177
              K    + K
Sbjct: 1799 GRKREQLIEK 1808



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 111/508 (21%), Positives = 222/508 (43%), Gaps = 58/508 (11%)

Query: 602  HKEKSKHQKDFHLEFGEKSNA--KIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
            +KE+  H K   ++   K     KI  +      +  +  +KK +K  +T KK  L   E
Sbjct: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK--LVQVE 1920

Query: 660  REKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
                K ++++  EK K   + +  + ++ +  + +  KE    + E + L    E +   
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRL---AEEKMRL 1977

Query: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
            +E K  L K    + S + K    E+   E   K+  E +    E++I  L  E   I  
Sbjct: 1978 VEGKETLSKGETPETSRQRKMTQVEQELFER--KLSLEEKILLHEDRI--LAMEESEIAK 2033

Query: 780  DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKE------------KPEKRSQ 827
             K  EFT      ++    L    +++ I+K+E   KE  +            + E++  
Sbjct: 2034 GK-LEFTRGQRIFVQGQRKLAKASRKL-IKKRESLSKEPAKLNKILKALQKLTRDERKLT 2091

Query: 828  IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGE- 886
             +E  + KM+R  F KE+++      E+ KLD+ E  D  +++ +L     +   K+ + 
Sbjct: 2092 QEEIKMTKMKRALFVKERRLS----IEQSKLDIKEW-DFSEKRSELTKDEKKLARKQRKL 2146

Query: 887  KSKNTAAIKKTDDREKSREKMDRKH------DKEK---------PEKERHLAESKEKHL- 930
             +K    I K +   +   K+ RKH      D+E+         P  +R   + KE    
Sbjct: 2147 ANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRG 2206

Query: 931  ---MEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 987
                EK + Q D  E   SE+  ++E +  LD+ EK   +ES++    +  +EE++    
Sbjct: 2207 DKPKEKFSSQVDEVE---SEEHFSEEMESLLDELEK---QESLSSEEEEEREEEEEREEE 2260

Query: 988  DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK-HKDKIQINSLLKLK 1046
            +  + + E+    +E  + +  K  + K+K KK+K  +  +E+++  ++K +I S  + +
Sbjct: 2261 EVREEEEERK-EEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETE 2319

Query: 1047 SEADKPKPKSSPASKDTRPKEKRLVNDD 1074
            S +D+ + + S + ++   +EK ++  +
Sbjct: 2320 SLSDEEEEEESCSLEEEVDREKEILKKE 2347


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
            protein 6 [Homo sapiens]
          Length = 724

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 97/451 (21%), Positives = 212/451 (47%), Gaps = 43/451 (9%)

Query: 603  KEKS-KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM------DKEGKTLKK--H 653
            KEK+ K Q+   L   EKS  ++  ++     E +   L +       D  GK L+    
Sbjct: 281  KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 340

Query: 654  KLKHKEREKEKHKKEIEGEKEK-YKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN 712
            KL+ +  E E   +  + ++EK ++ ++  +E +  ++   E  +E   K  E E+    
Sbjct: 341  KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400

Query: 713  MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKE 772
             E      E+K + ++ +  +K  +EK   +E    E+ +KI++  EK   +EKI++ +E
Sbjct: 401  QEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 458

Query: 773  ER---ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIK 829
            +R   E I   +  +     M   EE I     E+E  I +QE+ +   +EK  ++ +I+
Sbjct: 459  KRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEEKMWRQEEKIHEQEKIR 514

Query: 830  EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
            E++  + + + + +E+KI+ + +  + K  + E  +KI+++++      EK H + EK +
Sbjct: 515  EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574

Query: 890  NTAA---------------IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK--HLME 932
                               I++ +++ + +E+M ++ +++  E+E  + E +EK     E
Sbjct: 575  EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634

Query: 933  KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 992
            K  +Q +     + +  + +EK RE ++  + ++++          QEEK     +  + 
Sbjct: 635  KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE-------QEEKMCEQEEKMQE 687

Query: 993  QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1023
            Q EK    +EK  ++ ++    +EK ++ ++
Sbjct: 688  QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 111/515 (21%), Positives = 240/515 (46%), Gaps = 48/515 (9%)

Query: 661  EKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLT 719
            +K+K  + IE   E  K +D+   EL R+   D E  ++N    ++ +          L 
Sbjct: 248  QKKKADRYIE---ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ----------LV 294

Query: 720  LEKKSKLEKNIKDDKSTKE--KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777
              +KS+++ N+K+ K   E  K +  ++  + E D + KE +    + + +  + E  N 
Sbjct: 295  ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354

Query: 778  PTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI---KEKDIE 834
               +  E        I+E     + E+E  I +QE+ I+E +EK  ++ ++   KE+ + 
Sbjct: 355  LNQQQEEKMWRQEEKIQEWEE-KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413

Query: 835  KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 894
            + E   +EKE+K++ + +   +K    E + +++EK     H  EK  ++ EK +    I
Sbjct: 414  RQEEMMWEKEEKMRRQEEMMWEK---EEKIRELEEK----MHEQEKIREQEEKRQEEEKI 466

Query: 895  KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
            ++ + R++   KM R+ +K + E+E  + E +EK  M ++ ++    E  + E+ K +E+
Sbjct: 467  REQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEK--MWRQEEKIHEQEKIREEE-KRQEQ 522

Query: 955  DRELDKKEKSRDKESINITNSK-HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPD 1013
            +    ++EK R++E I     K H QEEK        + Q EK    +EK  D+  K  +
Sbjct: 523  EEMWRQEEKIREQEEIWRQKEKIHEQEEKI-------RKQEEKMWRQEEKMHDQEEKIRE 575

Query: 1014 GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVND 1073
             +EK  + ++  R +E    + + +I    ++  E ++         K    +EK    +
Sbjct: 576  QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE---------KMGEQEEKMCEQE 626

Query: 1074 DLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTES 1133
            + MQ   E+M   ++   EQ  K  +++ K +E+E +      ++  ++++  +      
Sbjct: 627  EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 686

Query: 1134 KNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVD 1168
            + +E  R +  ++ +   + +Q ++ +    + ++
Sbjct: 687  EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 76/358 (21%), Positives = 182/358 (50%), Gaps = 25/358 (6%)

Query: 641 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENF 700
           K  ++E K  ++ +   ++ EK + ++E+  EKE+   +      ++  +  R+  +E  
Sbjct: 376 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ--EEMM 433

Query: 701 FKSDETEDLFLNMEHESLTL---EKKSKLEKNIKDDKSTKEKHVS---KERNFKEERDKI 754
           ++ +E         HE   +   E+K + E+ I++ +  +E+      +E   +E+ +KI
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493

Query: 755 KKESEKSFR-EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEK 813
           +++ EK +R EEKI + ++ RE     +  E     M   EE I      ++ +I +Q++
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEE-----MWRQEEKI-----REQEEIWRQKE 543

Query: 814 HIKESKEKPEKRSQIKEKDIEKM---ERKTFEKEKKI-KHEHKSEKDKLDLSECVDKIKE 869
            I E +EK  K+ +   +  EKM   E K  E+E+K+ + E K  + +  + E  +KI+E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603

Query: 870 KDKLYSHHTEKCHKEGEK-SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928
           ++++     EK  ++ EK  +    +++ +++ + +E+  R+ +K+  E+E  + E +E+
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-QEE 662

Query: 929 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986
            + E++ K  +  E    ++ K +E++ ++ ++E+   ++ + +   +   +E +  +
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 87/492 (17%), Positives = 209/492 (42%), Gaps = 61/492 (12%)

Query: 378 RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSR---VLYSSTESSDEEAL 434
           R+ +  E+ KE   + ++     + EK+    + K  K+K  R   +L      ++ + L
Sbjct: 272 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 331

Query: 435 QNKKISTSCSVIPETSNSDM-----QTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELK 489
             +  S S  +  +   +++     Q ++E +   E K +   ++  + + K +E +E  
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391

Query: 490 QEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCG 549
           +E+E K   +   +      +  EK R +    +    K++       +   K  K    
Sbjct: 392 REQEEKMRRQEEMMW-----EKEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEK---- 439

Query: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
           + E +    +QE  +        E  ++    R +  E++   +   ++  + K + + +
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEE 498

Query: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREK--EKHKK 667
           K +  E       KI++E+     E      +K+ ++ +  ++ +  H++ EK  ++ +K
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558

Query: 668 EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLE 727
               E++ +  ++  +E +  V    E  +E   K  E E+     E E +T E++ K+ 
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI--REQEEMTQEQEEKMG 616

Query: 728 KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTS 787
           +        +EK   +E   +E+ +K++++ EK   +E  K ++E+ E I          
Sbjct: 617 EQ-------EEKMCEQEEKMQEQEEKMRRQEEKIREQE--KKIREQEEKIR--------- 658

Query: 788 LGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEK---PEKRSQIKEKDIEKMERKTFEKE 844
                          E+E  +++QE+ + E +EK    E++ Q +E+ + + E K +E+E
Sbjct: 659 ---------------EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703

Query: 845 KKIKHEHKSEKD 856
            +++ + +  ++
Sbjct: 704 VRLRQQEEKMQE 715



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 59/317 (18%), Positives = 134/317 (42%), Gaps = 23/317 (7%)

Query: 842  EKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-----EKSKNTAAIKK 896
            E    I   H S K   +L + +  +  + K    + E+  KE      E  +NT   ++
Sbjct: 220  EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 279

Query: 897  TDDREKSREKMDRKHDKEKPEKERHLAESKEKH-----LMEKKNKQSDNSEYSKSEKGKN 951
              ++    ++  +  + EK E + ++ E K K      L+ ++  Q++     K  +  +
Sbjct: 280  LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 339

Query: 952  KEKDRELDKKEK----SRDKESINITNSKHIQE--EKKSSIVDGNKAQHEKPLSLKEKTK 1005
             +   ++++ E     ++ +E       + IQE  EK     +  + Q EK    +EK +
Sbjct: 340  AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 399

Query: 1006 DEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRP 1065
             +     + +EK ++ +++   KE    K + Q   + + + +  + + K     K    
Sbjct: 400  RQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 456

Query: 1066 KEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEK 1125
            +EKR   + + +    +    K    E+  ++ +EKI+++E++  R     E KI ++EK
Sbjct: 457  EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ----EEKIHEQEK 512

Query: 1126 TKHTPTESKNKELTRSK 1142
             +      + +E+ R +
Sbjct: 513  IREEEKRQEQEEMWRQE 529


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 230/1127 (20%), Positives = 473/1127 (41%), Gaps = 147/1127 (13%)

Query: 279  QANKHGERPVDVAET-----EELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
            Q  ++G   VDV +       + E+  K E P SD +    D    +++           
Sbjct: 233  QRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL----------- 281

Query: 334  ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 393
            ET +  +  +   +   K  + S  ++      + E + + +D+R  L++ ++ ++   A
Sbjct: 282  ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER--LQELEKIKDLHMA 339

Query: 394  EKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKK--ISTSCSVIPE--T 449
            EKT L  +   A   K+   + ++   ++ + T+    E L+ K+  I+   S I +  T
Sbjct: 340  EKTKLITQLRDA---KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396

Query: 450  SNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKE-NQELKQEKEGKENTRITNLTVNTG 508
               +++ +KE     E     ++++ L    K +E  ++LK E + +  T          
Sbjct: 397  QGEELREQKE---KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT---------- 443

Query: 509  LDCSEKTREEG--NFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTC 566
                EKT EE   + ++  S      + +   S+ +       L EK+    +QE TK  
Sbjct: 444  ---IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500

Query: 567  LSPGSSEMSLQPDL-VRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEK-----S 620
             +    E   Q  + V  + ++SE+L      K  + KE+ +      LE  +K     S
Sbjct: 501  QT---REREFQEQMKVALEKSQSEYL------KISQEKEQQESLALEELELQKKAILTES 551

Query: 621  NAKIKD-----EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK 675
              K++D     E +       + +L+K  +E K   K    H E EK KH KEI    EK
Sbjct: 552  ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611

Query: 676  YKTK-DSAKELQRSVEFDR-EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD- 732
            +KT+ +S K  Q ++  ++ +  K+ +    E        E E+L  +K+   + +I++ 
Sbjct: 612  HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671

Query: 733  DKSTKEKHVSKE---RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
            ++ T EK   K+    +   E  ++ K   K   EE++  LK++ + +  + +++     
Sbjct: 672  NEKTLEKLDVKQTELESLSSELSEVLKARHK--LEEELSVLKDQTDKMKQELEAKMDE-Q 728

Query: 790  MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
             +  ++ +   + E E+ I++ EK +K+   + E   + ++K +++ +      E  IK 
Sbjct: 729  KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788

Query: 850  ---EHKSEKDKLDLSECVDK-IKEKDKLYSHHTEKCHKE--GEKSKNTAAIKKTDDREKS 903
               E +    KLD+ +       E+ K Y     +  ++    +++     K+  + E  
Sbjct: 789  SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848

Query: 904  REKMDRKHDKEKPEKERHLAE-SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE---LD 959
            ++ +  + D  K + +  + +  K+   ME+K K       SK E G NKE+++    L 
Sbjct: 849  KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG-NKEQEQTKQILV 907

Query: 960  KKE------KSRDKESINITNSKHIQEEKKSSIVDGN-----KAQHEKPLSLKEKTKD-- 1006
            +KE      +   K+ I I   K   +E    I++       K Q +K   +K+K K+  
Sbjct: 908  EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967

Query: 1007 EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1066
            E LK     ++ K  K+++        K+K Q N+ +   ++A+      + +  +T  K
Sbjct: 968  ETLKKKLLDQEAKLKKELENTALELSQKEK-QFNAKMLEMAQANSAGISDAVSRLETNQK 1026

Query: 1067 E---------KRLVNDDLMQTSFERMLSLKDLEIEQWHK---KHKE----KIKQK----- 1105
            E         +R +ND +  + +E+ L+ +  E+++ H+   + KE    ++KQK     
Sbjct: 1027 EQIESLTEVHRRELNDVI--SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG 1084

Query: 1106 -EKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRS 1164
             EKE + N+    LK   +E  K   T ++ +E  + KS+ V      E + K  +    
Sbjct: 1085 CEKEEM-NKEITWLK---EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL---- 1136

Query: 1165 QSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPR 1224
            + ++     +L +++F+ +  +     +E +K  +S  +  + +      S  ++     
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196

Query: 1225 PPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTS 1284
              +E   D  LE  +     +    +   K+ AL E + + L ++         +R+S  
Sbjct: 1197 KSLE---DKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253

Query: 1285 HLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESN 1331
              R++ V++  LI          + C+    + E   Q + ++EE N
Sbjct: 1254 QHRTTKVKEALLI----------KTCT----VSELEAQLRQLTEEQN 1286



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 184/933 (19%), Positives = 380/933 (40%), Gaps = 118/933 (12%)

Query: 277  PFQANKHGERPVDV-AETEELELLLKREVPLSDDDESYTDSEEAQ-------SVNPSSVD 328
            P QA+ +   P  + + T      L    P  +  ++ + +++ Q       S+  S + 
Sbjct: 22   PAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIK 81

Query: 329  ENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE 388
            E++   + K+SL+  S +   ++  L S+   ++   D D E   ++ +   L KEQ  +
Sbjct: 82   ESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQ 141

Query: 389  NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV--- 445
                 E++    + + +    +++  +++  ++    ++S D+   +  ++     +   
Sbjct: 142  RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQ 201

Query: 446  ----IPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRIT 501
                + E  ++ ++ K +Y +S    Q   +K++L+N   N +   LK   + +    + 
Sbjct: 202  AKKHLQEEFDASLEEKDQY-ISVLQTQVSLLKQRLRNGPMNVD--VLKPLPQLEPQAEVF 258

Query: 502  NLTVNTGLDCSEKTREEGNFRKSFSP-----KDDTSLHLFHISTGKSPKHSCGLSEKQST 556
                N   D  E   E+G   K+        K   +L      T +S K  C L   +  
Sbjct: 259  TKEENPESD-GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317

Query: 557  PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTE--SEFLPESSSVKSCKHKE-----KSKHQ 609
             L+++     L     E+    DL   + T+  ++     + ++  +  +     ++K Q
Sbjct: 318  ALQEQ-----LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372

Query: 610  KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
                LE  E+  A+++              +K+M  +G+ L++ K K +    E+ +K +
Sbjct: 373  MHETLEMKEEEIAQLRSR------------IKQMTTQGEELREQKEKSERAAFEELEKAL 420

Query: 670  EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNME-----HESLTLEKKS 724
                    T    +E +R ++ + +   +   K+ E E + L  E      E + + KKS
Sbjct: 421  -------STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473

Query: 725  ------KLEKNIKDDKSTKEKHVSK-----ERNFKEERDKIKKESEKSFREEKIKDLKEE 773
                  KL+K  + + + KE+ ++K     ER F+E+     ++S+  +   KI   KE+
Sbjct: 474  SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQ 531

Query: 774  RENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQI--KEK 831
            +E++              A+EE   L L +K I  E + K     +E    R++I   E 
Sbjct: 532  QESL--------------ALEE---LELQKKAILTESENKLRDLQQEAETYRTRILELES 574

Query: 832  DIEK--MERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
             +EK   E K   K+  +  E +  K   +++  V+K K + +   H  +    E     
Sbjct: 575  SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE---KL 631

Query: 890  NTAAIKKTDDREKSREKMDRKHDKEKPEKE----RHLAESKEKHLMEKKNKQSD----NS 941
                 +   + EK REK +++ +    +KE     H+ E  EK L +   KQ++    +S
Sbjct: 632  QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691

Query: 942  EYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
            E S+  K ++K  + EL   +   DK    +      Q+      VD    +HE  +   
Sbjct: 692  ELSEVLKARHK-LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRT 750

Query: 1002 EKTKDEPLKTPD--GKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1059
            EK   + +   +   KE+DK  K+   + E  +   K     L +  ++ D  +   S  
Sbjct: 751  EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810

Query: 1060 SKDTRPKEKRL--VNDDLMQTSFERMLSLKDLEIEQWHKK--------HKEKIKQKEKER 1109
             + T+  E++L  +   L+    ER+L  K +   +  KK        HK +++   ++ 
Sbjct: 811  HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870

Query: 1110 LRNRNCLELKIKDKEKTKHTPTESKNKELTRSK 1142
             +  + +E K+K   +   +  E  NKE  ++K
Sbjct: 871  EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 170/851 (19%), Positives = 336/851 (39%), Gaps = 119/851 (13%)

Query: 370  EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESS 429
            +I  ++ ++  L+KE   + +  +EK     + +K        S+      ++    +  
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL------SENINAVTLMKEELKEK 1365

Query: 430  DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ---------- 479
              E     K  T  +V  +  NS   ++KE  +S   KQ  + K +L +Q          
Sbjct: 1366 KVEISSLSKQLTDLNV--QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT 1423

Query: 480  ----------------NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRK 523
                            NK  E ++  Q +  +    +  L +   L   E   ++     
Sbjct: 1424 LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 524  SFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRY 583
                 D  +   F    G+         +K     K+ + +T L   ++ +    D +  
Sbjct: 1484 LKEELDQQNKR-FDCLKGEME------DDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536

Query: 584  DNTESEFLPES----SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD-EDHSPTFENSDC 638
               E E L E     +  K  +HKE  +  + F  E GE+ + ++K+ E+   T EN   
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQVY 1595

Query: 639  TLK-KMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKE--------KYKTKDSAKELQRSV 689
            ++K +++ + K L+   L  K +E+E    E   E E        K K +     +++ +
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655

Query: 690  EFDREFWKENFFKSDETEDLFLNM-----EHESLTLEKKSKLEKNIKDDKSTKEKHVSKE 744
                E  +E + K  E+    LN      E E   LE+K K  ++ + +     +     
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715

Query: 745  RNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV-- 802
              + E+ +   +   +   EEKI  L+       T+K+     +G    EE++  H    
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNL----TEKEKLLQRVGQEK-EETVSSHFEMR 1770

Query: 803  ----EKEIDIEKQEK----------HIKES-KEKPEKRSQIKEKDIEKMERKT-FEKEKK 846
                E+ I +E  E           H++E  +EK +K S I  + +EK   K   + ++ 
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN 1830

Query: 847  IKHEHKSEKDKLDLSECV-----DKIKEKDKLYSHHTEKCHKEGE----KSKNTAAIKKT 897
            +++     +  L   E        KIKE D       E    E E    K +   A+++ 
Sbjct: 1831 LENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890

Query: 898  DDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD----NSEYSKSEKGKN-- 951
            D R K  E ++   +++    + HL + K    ME ++   +     +E  K + GK   
Sbjct: 1891 DGRNKPTELLEENTEEKS---KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV 1947

Query: 952  -KEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLK 1010
              +KD  + +KE  ++ E +     K   +E++  I      Q ++ L LK  +  + L 
Sbjct: 1948 RLQKDLRMLRKEHQQELEILK----KEYDQEREEKI-----KQEQEDLELKHNSTLKQLM 1998

Query: 1011 TPDGKEKDKKDKDIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1069
                 +  +K+++++   KE      +++   L   + E ++   K +    D +   KR
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058

Query: 1070 LVNDDLMQTSFERMLS-LKDLE--IEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKT 1126
               ++++    E M + ++DL+  +E+  KK+++K++Q+E     N   +EL+ +  +KT
Sbjct: 2059 Y--EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116

Query: 1127 KHTPTESKNKE 1137
                ++SK KE
Sbjct: 2117 T-LISDSKLKE 2126



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 187/911 (20%), Positives = 376/911 (41%), Gaps = 131/911 (14%)

Query: 343  ESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQ 402
            + +++    + L +  +E++      E+ NK ++D+ +   E +K +E  A +  +  K+
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL---EFKKLSEELAIQLDICCKK 1223

Query: 403  EKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVV 462
             +A                     ++++   + + K +   S I    +   + K+  ++
Sbjct: 1224 TEALL-----------------EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266

Query: 463  SG--EHKQKGKVKRKLKNQNK-NKENQELKQEKEGKENTRITNLTVNTGLDCSEKT---R 516
                  + + ++++  + QN  N   Q+   + E KEN +I ++  +     +EK    +
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN-QIKSMKADIESLVTEKEALQK 1325

Query: 517  EEGNFRKSFSPKDDTSLHLF-HISTG-----------KSPKHSCGLSEKQSTPLKQEHTK 564
            E GN +++ S K+     L   +S             K  K       KQ T L  +  +
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ-LQ 1384

Query: 565  TCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS-----CKHKEKSKHQ-KDFHLEFGE 618
              +S    E ++     +YD  + E L +   +        K K  +  Q  D+  +F E
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444

Query: 619  -KSNAKIKDEDHSPTFENSDCTLKKMDKEGK------TLKKHKLKHKEREKEKHKKEIEG 671
             K  A+ +   H  T +     L+   KE         L K +L  + +  +  K E+E 
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504

Query: 672  EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
            +K K + K+S  E +          K    +  E ED   ++  +++ +E  +++ KN  
Sbjct: 1505 DKSKMEKKESNLETE---------LKSQTARIMELED---HITQKTIEIESLNEVLKNYN 1552

Query: 732  DDKSTKEKH-VSKERNFK---EERDKIKKESEKSF--REEKIKDLKEERENIPTDKDSEF 785
              K  + K  V K ++F+   EE+D   KE+E+     E ++  +K E E     K+ E 
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET--KKKELEH 1610

Query: 786  TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEK 845
             +L + + EE   L  +E  ++ E   K  +  ++  +K + IK++ + +ME K  E+ K
Sbjct: 1611 VNLSVKSKEEE--LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE-EQYK 1667

Query: 846  KIKHEHKSE-KDKLDLSEC-VDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKS 903
            K    H SE   KL   E  V  ++EK K       +       +KN AA  + ++ + S
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD-S 1726

Query: 904  REKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 963
            +  + + ++++    +R+L E KEK L+++  ++ + +  S  E     +    L K E 
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTE-KEK-LLQRVGQEKEETVSSHFE--MRCQYQERLIKLEH 1782

Query: 964  SRDKESINITNSKHIQEE-----KKSSIV-------DGNKAQHEKPLSLKEKTKDEPLKT 1011
            +  K+  + +   H+QEE     KK S++       +G K   +   +L E   D+  KT
Sbjct: 1783 AEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL-ENVFDDVQKT 1841

Query: 1012 PDGKE-----KDKKDKDIDRYKERDKHKDKIQINSL---------LKLKSEADKP----K 1053
               KE      ++K K++D    R K   ++++  L         L+     +KP    +
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901

Query: 1054 PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLE--------------IEQWHKKHK 1099
              +   SK    + K L N +      E  L+  + E              +    K+H+
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961

Query: 1100 EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
            ++++  +KE  + R   E KIK +++       S  K+L R  ++++     + +     
Sbjct: 1962 QELEILKKEYDQER---EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018

Query: 1160 VSNRSQSVDTK 1170
              N++Q V+ +
Sbjct: 2019 TINKAQEVEAE 2029



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 137/717 (19%), Positives = 290/717 (40%), Gaps = 131/717 (18%)

Query: 308  DDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEY--EFKD 365
            +DD+S  + +E      S+++  + S+T +   I E +  +  KT    +L+E    +  
Sbjct: 1503 EDDKSKMEKKE------SNLETELKSQTAR---IMELEDHITQKTIEIESLNEVLKNYNQ 1553

Query: 366  DDDEEINKMIDD-RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYS 424
              D E  +++   +H     + K+N  +  +  +   + + +  K+    K+K    +  
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613

Query: 425  STESSDEE--ALQNKKISTSCSVIPETSN--------------SDMQTKKEYVVSGEHKQ 468
            S +S +EE  AL+++  S S + + E                 S M+ K+E    G    
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673

Query: 469  KGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDC------SEKTREEGNFR 522
              ++  KL  Q + +E   L+++ +  E+++   L V             E+   +G  +
Sbjct: 1674 LSELNTKL--QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731

Query: 523  KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 582
            K++  K                + +    EK    + QE  +T  S        Q  L++
Sbjct: 1732 KTYEEKISVL------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779

Query: 583  YDNTESEFLPESSSVKSCKHKEKSKHQKDF-----HLEF-GEKSNAKIKD------EDHS 630
             ++ E++   + S +   + + + K++K       H+E  G K+N + K       +D  
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839

Query: 631  PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 690
             T +  + T + ++++ K L    +    R+KE H+ E+E    KY+   + +++     
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLV----RQKEVHRVEMEELTSKYEKLQALQQMDG--- 1892

Query: 691  FDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEE 750
                       ++  TE L  N E +S +   + KL  N++   +  E  ++       E
Sbjct: 1893 -----------RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA-----E 1936

Query: 751  RDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK 810
            R+K K   E    ++ ++ L++E +                       L +++KE D E+
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQ---------------------ELEILKKEYDQER 1975

Query: 811  QEKHIKESKEKPEKRSQI---------------KEKDIEKMERKTFEKEKKIKHEHKSEK 855
            +EK IK+ +E  E +                  KE+++E   ++T  K ++++ E   E 
Sbjct: 1976 EEK-IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLES 2033

Query: 856  DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH---- 911
             + + ++ + KI EKD      T K ++E   ++      K  D +   E++ +K+    
Sbjct: 2034 HQEETNQLLKKIAEKDDDLK-RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092

Query: 912  -DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967
              +E P  +       +  L +K    SD    SK ++ + +E+   L+ + K  +K
Sbjct: 2093 EQEENPGNDNVTIMELQTQLAQKTTLISD----SKLKEQEFREQIHNLEDRLKKYEK 2145


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 191/946 (20%), Positives = 381/946 (40%), Gaps = 139/946 (14%)

Query: 329  ENIDSETEKDSLICES----KQILPSKTPLPSALDEYEFKD--DDDEEINKMIDD-RHIL 381
            EN+ +E E+   + E+    KQ L  K     A  +   K   + ++E+ +M +  R   
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682

Query: 382  RKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST 441
            + +Q+K  E E E   L A+   A          ++    L SS  S  EE  + K    
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPA------GDTAKECMETLLSSNASMKEELERVKMEYE 1736

Query: 442  SCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGK-----E 496
            + S   ++  S+  +  E V   +H+ +G V ++   +   K + +    +EG      E
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796

Query: 497  NTRITNLTVNTGLDCSEKTREEGNFR----KSFSPKDDTSLHLFHISTGKSPKHSCGLSE 552
                 +L+++T   CSE      +      K FS  D+ + +L  I   K  +   GL E
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK--ERIAGLEE 1854

Query: 553  -----KQSTPLKQEHTKTCLSPGSSE----MSLQPDLVRYDNTESEFLPESSSVKSCKHK 603
                 K+ +   +    T LS  S++      LQ ++ + +    +   E S V   K K
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT--KLK 1912

Query: 604  EKSKHQKDFHLE----------------FGEKSNAKIKDEDHSPTFENSDCTLKKMDKEG 647
            E ++ +KD   E                  + ++A+IK+E      +N    + ++++E 
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEK 1972

Query: 648  KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE 707
            + L K K K +   ++++ ++I+G +++   K  AKELQ       E  KE   K  E +
Sbjct: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ-------ELLKE---KQQEVK 2022

Query: 708  DLFLNMEHESLTLEKKSKLEKNIK-----DDKSTKEKHVSKERNFKEERDKIKKESEKSF 762
             L  +        EK S LE+ +K       +S K+  ++KE   +    + K ++E + 
Sbjct: 2023 QLQKDCIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079

Query: 763  REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEK-----QEKHIKE 817
             +  + D + E   +  D         + + +ES+   + +K+ D+E+     +EKH+KE
Sbjct: 2080 FKVLLDDTQSEAARVLADNLK--LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137

Query: 818  SKEKPEKRSQIKEKDIEKME-----RKTFEKEKKIKHEHKSEKDKL-------------- 858
             K   EK   ++ + +   E     + T  K+ K   + +   D                
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197

Query: 859  --DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP 916
              D    +D+ K+ ++ +S   +   +E    ++  ++ K   R+ S    + K +  + 
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257

Query: 917  EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976
            E ++ + ESK +  ++ + K  D  +      G+NKE   +L++              ++
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQ------GENKELLSQLEE--------------TR 2297

Query: 977  HIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKD 1035
            H+    ++ +     A+ E  L SLK++  D        KE+    + I R +E D    
Sbjct: 2298 HLYHSSQNEL-----AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352

Query: 1036 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1095
            K    S  +L+++    +  +S   ++   KE+++++   + +  E  + +   E+ Q H
Sbjct: 2353 KF---SYEQLETDLQASRELTSRLHEEINMKEQKIIS---LLSGKEEAIQVAIAELRQQH 2406

Query: 1096 KKH-KEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKE- 1153
             K  KE      +E   N    E   K  +KT       K  +    +     D++ K  
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466

Query: 1154 ---KQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEK 1196
               +  +D +    Q ++ +++     S  +  + L +   +EN K
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHL-----SIILEKDQLIQEAAAENNK 2507



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 194/996 (19%), Positives = 393/996 (39%), Gaps = 132/996 (13%)

Query: 369  EEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTES 428
            ++I + +    I RKE  KEN+   E+  L     +    +  KS     S+V   + E 
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSL----ARGTIERLTKSLADVESQVSAQNKEK 1534

Query: 429  S--------------------DEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQ 468
                                 D   L+N+ +S+SC  +        + K++ V   E  +
Sbjct: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594

Query: 469  KGKVKRKLKNQNKNKENQE------LKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFR 522
              K+    + Q K+KE Q+         E    E  RI ++         EK    G  R
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR---QEKQELYGKLR 1651

Query: 523  KSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVR 582
             + + K +T   L               +E++   +K++  K   S     + L+ +   
Sbjct: 1652 STEANKKETEKQLQE-------------AEQEMEEMKEKMRKFAKSKQQKILELEEE--- 1695

Query: 583  YDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKK 642
             D   +E  P   + K C             +E    SNA +K+E      E      + 
Sbjct: 1696 NDRLRAEVHPAGDTAKEC-------------METLLSSNASMKEE-----LERVKMEYET 1737

Query: 643  MDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFK 702
            + K+ ++L   K    E E +  K +IEG   K    ++ ++         E  +     
Sbjct: 1738 LSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS---I 1793

Query: 703  SDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-------RNFKEERDKIK 755
              ETE      E +SL++  +    +++   KS     VSK+        N+ ++ D++K
Sbjct: 1794 PGETE------EQDSLSMSTRPTCSESVPSAKSANPA-VSKDFSSHDEINNYLQQIDQLK 1846

Query: 756  K-----ESEKSFREEKIKDLKEERENIPTD---KDSEFTSLGMSAIEESIGLHLVEKEID 807
            +     E EK   +E  + L+ E+  + +    KD E   L     + ++    +++E+ 
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906

Query: 808  -IEKQEKHIKESKEKPEKR--SQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 864
             + K ++  +E K+  E+R  +Q+ E +           + +IK+E   E +  +L +CV
Sbjct: 1907 RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE-LLESEMKNLKKCV 1965

Query: 865  DKIKEKDKLYSHHTEKCHKEGEK---SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
             +++E+ +       K   E  K    K   A K+  ++  ++E  +   +K++  K+  
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025

Query: 922  LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE-LDKKEKSRDKESINITNSKHIQE 980
                + +  +    +     E+ ++E  K+ E  +E L +  + R K    + + K + +
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085

Query: 981  EKKSS---IVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1037
            + +S    ++  N    ++  S KE  K +  +  +  E+  +  +    KE+   ++K+
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145

Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE------RMLSLKD--- 1088
                  K+  E    + + +   KD   KE + + ++L  T  +       M SL+D   
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKD---KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRD 2202

Query: 1089 ---LEIEQWHKKHKEKIKQKEKE-RLRNRNCLELKIKDKEKTKHTPTESKN-KELTRSKS 1143
                E ++W +K  + I+ KE+E RL+  NC  LK + ++ + H      N   L   K 
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262

Query: 1144 SEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENE----KPGL 1199
               + A T E Q +  V +  Q  + + +  L ++  +  +S N   + E+E    K  L
Sbjct: 2263 IWESKAQT-EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321

Query: 1200 SSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALH 1259
            +  S S+      + +    +      ++ +S F  E  E+ +  S+     + +   + 
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEADIQ-NSKFSYEQLETDLQASRELTSRLHEEINMK 2380

Query: 1260 ERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVK 1295
            E+++ SL    E      A +++ + LR    +++K
Sbjct: 2381 EQKIISLLSGKEE-----AIQVAIAELRQQHDKEIK 2411



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 190/912 (20%), Positives = 356/912 (39%), Gaps = 148/912 (16%)

Query: 314  TDSEEAQSVNPSSVDENIDSETEK-DSLICESKQILPSKTPLPSALDEYEFKD-DDDEEI 371
            T+  + Q+       ++I  ETE+ DSL   ++       P   + +    KD    +EI
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835

Query: 372  NKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDE 431
            N  +     L KE+    E E +K             K F    +     L S   + D 
Sbjct: 1836 NNYLQQIDQL-KERIAGLEEEKQKN------------KEFSQTLENEKNTLLSQISTKDG 1882

Query: 432  EA-----------LQNKKISTSCSVIP---ETSNSDMQTKKEYVVSGEHKQKGKVKRKLK 477
            E            L N++I    S +    ET+  +    +E +++   +  G +    +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942

Query: 478  NQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFH 537
            +    +   EL + +       ++ L         EKT+ E   RK +  K         
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQ------- 1995

Query: 538  ISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSV 597
                K P +     E Q   LK++  +           LQ D +RY    S       +V
Sbjct: 1996 -GAQKEPGNKSHAKELQEL-LKEKQQEV--------KQLQKDCIRYQEKISAL---ERTV 2042

Query: 598  KSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKH 657
            K+ +  + ++ QKD  +     + A    +       +    L     E   +    LK 
Sbjct: 2043 KALEFVQ-TESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101

Query: 658  KEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHE- 716
            K +E + +K+ ++ +  K K +D  + L+++ E   +  K    K D      +++E   
Sbjct: 2102 K-KELQSNKESVKSQM-KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159

Query: 717  ---SLTLEKKSK----LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKD 769
                +TL KK K    L++N+    +          + +++RD++  E++K   E K  D
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW--ERKFSD 2217

Query: 770  LKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEKRSQ 827
              + +E     K+   + L     + SI  H+ E +I+I + E  K I ESK + E + Q
Sbjct: 2218 AIQSKEEEIRLKEDNCSVLKDQLRQMSI--HMEELKINISRLEHDKQIWESKAQTEVQLQ 2275

Query: 828  IKEKDIEKMERKTFEKE---------------KKIKHEHKSEKDKL-DLSECVDKIKEK- 870
             K  D  + E K    +                K++ E KS KD+L DLS  ++K KE+ 
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335

Query: 871  ---------------DKLYSHH------------TEKCHKEGEKSKNTAAIKKTDDREKS 903
                           +  +S+             T + H+E    K    I     +E++
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE-INMKEQKIISLLSGKEEA 2394

Query: 904  RE----KMDRKHDKEKPEKERHLAESKEKHLM---------EKKNKQSDNSEYSKSEKGK 950
             +    ++ ++HDKE  E E  L++ +E++++         +K N+     E  K+ K +
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL---METLKTIKKE 2451

Query: 951  NKEKDRELDKKEKS-----RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL---SLKE 1002
            N ++  +LD   KS      D++ I + + + ++E   S I++ ++   E       LKE
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRI-VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510

Query: 1003 KTKDEPLKTPD-GKEKDKKDKDIDRYKERDKH----KDKIQINSLLKLKSEADKPKPKSS 1057
            + +       D   E  K D ++ +Y+E        KD  Q   LL+++ + +K + ++ 
Sbjct: 2511 EIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS-QQKQLLEVQLQQNK-ELENK 2568

Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDL--EIEQWHKKHKEKIKQ---KEKERLRN 1112
             A  + + KE    N+DL ++        +DL  EIE       +  +Q    ++E    
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628

Query: 1113 RNCLELKIKDKE 1124
                +LK+K++E
Sbjct: 2629 LYHAQLKVKEEE 2640



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 245/1292 (18%), Positives = 468/1292 (36%), Gaps = 222/1292 (17%)

Query: 51   EMKEKSSMKRKLPFTISPSRN-EERDSDTDSDPGHTS---ENWGERLISSYRTYSEKEGP 106
            E K K+ M+ K    +S  +  +E  S  D+     S   ++  E+ + S +T  + E  
Sbjct: 367  EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426

Query: 107  EKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKK 166
             ++K+K+ +          L   PL + +        TA   S     N  +Q    +  
Sbjct: 427  LQQKSKEIS--------QFLNRLPLQQHE--------TASQTSFPDVYNEGTQAVTEE-- 468

Query: 167  TPSSSSRQKDKVNKRNERGE---TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLH 223
              + +S QK  V   NE+G    + + +  ++ + +++   I+L    N    A      
Sbjct: 469  --NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD----R 522

Query: 224  EACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNP------ 277
            E   +   D+A       +     G D    L ++ S  H+++  LLL            
Sbjct: 523  EVSEISIVDIAN---KRSSSAEESGQD---VLENTFSQKHKELSVLLLEMKEAQEEIAFL 576

Query: 278  ---FQANKHGERPVDVAETEELELL-------LKREVPLSDDDESYTDSEEAQSVNPSSV 327
                Q  +  E   +V + +E++ +       +K +V L D  + +      +S  P+  
Sbjct: 577  KLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE 636

Query: 328  DENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRK 387
             E   + TE  S   E   +  +   L S       K D D+ ++ + D     + E  +
Sbjct: 637  KEQ--ASTEHQSRTSEEISLNDAGVELKST------KQDGDKSLSAVPDIGQCHQDELER 688

Query: 388  ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIP 447
                  E    F K ++  Y K+   K ++ S  L    E   + A  N    T+ S   
Sbjct: 689  LKSQILELELNFHKAQE-IYEKNLDEKAKEISN-LNQLIEEFKKNADNNSSAFTALS--E 744

Query: 448  ETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 507
            E      Q K+  +V+   + + +VK+   N  + +  + L  E +   +  +T    + 
Sbjct: 745  ERDQLLSQVKELSMVT---ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801

Query: 508  GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 567
             ++   K  +    +      DD  L     ST      S  L  K+S  L+       +
Sbjct: 802  SIEAKSKDVKIEVLQNEL---DDVQLQFSEQSTLIRSLQS-QLQNKESEVLEGAERVRHI 857

Query: 568  SPGSSEMS--LQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG-EKSNAKI 624
            S    E+S  L    +     +   L +   V++ +   + K Q+   + F   +   ++
Sbjct: 858  SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917

Query: 625  KDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIE-------GEKEKYK 677
             +E  S            +  E KTLK+ +L    R +E  K+++E       G K+ Y 
Sbjct: 918  NEEKFS------------LGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964

Query: 678  TKDSAKELQRSVEFDREF---WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD-- 732
                A ++ +  E   EF    KEN  +  + +   +N +     L++ S+LE+ + +  
Sbjct: 965  EMSPAGQISKE-ELQHEFDLLKKENEQRKRKLQAALINRKE---LLQRVSRLEEELANLK 1020

Query: 733  DKSTKEKHVSKERNFKEERDKIKKE----------------------------------- 757
            D+S KE  +S+    + E DK  KE                                   
Sbjct: 1021 DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080

Query: 758  SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI----------------GLHL 801
             EK   EE+ + L ++      DK ++   L     E                    + L
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140

Query: 802  VEKEIDI-------------EKQEKHIKESKEKPEKRSQIKEKDIEKME--RKTFEKEKK 846
            V++ + I             E +EK +   KEK + + +++E    +    +K  EKE+ 
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200

Query: 847  IKHEHKSEKDKLD-LSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSRE 905
            ++ E K +KD  + L E  D+  ++++       +   +  +S +   +  TD +E    
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESID-GKLPSTDQQESCSS 1259

Query: 906  KMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSR 965
                +    K  ++ H     E +L         +SE + + +G       +   KE   
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCP---DWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316

Query: 966  DKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDID 1025
            +K  + +  S    E  K S         E+   L+E+   + L+    K    + +   
Sbjct: 1317 EKVELELKVSSTTSELTKKS---------EEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367

Query: 1026 RYKERDKHKDKIQI---NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE- 1081
               ++     ++QI     L +L+ + D+ +   S   +D      +L   +   T  + 
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427

Query: 1082 RMLSLKDL------EIEQWHKKHKEKIKQ--------KEK-----ERLRNRNCLELK--- 1119
             ++  +DL      ++E   K+H E+IKQ        K+K     E  R +  ++ K   
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487

Query: 1120 --IKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGK 1177
              I  KE  K   +  +   L R     +T +       +  VS +++  DT     LG+
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLA---DVESQVSAQNKEKDT----VLGR 1540

Query: 1178 SSFVS---DNSLNRSPRSENEKPGLSSRSVSM 1206
             + +    D  +    RS  E   LSS   S+
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQSLSSSCESL 1572



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 84/411 (20%), Positives = 170/411 (41%), Gaps = 52/411 (12%)

Query: 823  EKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCH 882
            E +  I++KD++  ++    +E++   ++K +K KL         K K    + + E+  
Sbjct: 63   ELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA-------KAKLTSLNKYIEEMK 115

Query: 883  KEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD-NS 941
             +G     T         E   E+   KHDK   E+E  + + K K L EK+   S   +
Sbjct: 116  AQGGTVLPT---------EPQSEEQLSKHDKSSTEEEMEIEKIKHK-LQEKEELISTLQA 165

Query: 942  EYSKSEKGKNKEKDRELDK----KEKSRDKESINITNSKHIQ----EEKKSSIVDGNKAQ 993
            + ++++  +  +   E+++    K++ ++KE    T    +     E+    +V    A+
Sbjct: 166  QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDAR 225

Query: 994  HEKPLSLKEKTKDEPLK--TPDGKEKDKKDKDIDRYKERDKHKDKI-------------- 1037
             E  + L E   DE L+  T    E + + K     ++ ++H++ +              
Sbjct: 226  FETQVRLHE---DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282

Query: 1038 ----QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1093
                Q N +L  + +  + +  +   + +T  +E +++ + +     ER LS  +L+ E 
Sbjct: 283  TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342

Query: 1094 WHKKHK-EKIKQKEKERLRNRNCLELKIKDK--EKTKHTPTESKNKELTRSKSSEVTDAY 1150
             H   + E+  Q + E     + LE K K +  EKT H  +  K  +  +S    + D  
Sbjct: 343  HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402

Query: 1151 TKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSS 1201
            +K  Q K+  + +S     +    L + S      LNR P  ++E    +S
Sbjct: 403  SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 105/605 (17%), Positives = 239/605 (39%), Gaps = 78/605 (12%)

Query: 631  PTFENSDCTLKKMDKEG--KTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS 688
            PT   S+  L K DK    + ++  K+KHK +EKE+    ++ +  + + +  A   Q S
Sbjct: 123  PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA---QSS 179

Query: 689  VEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFK 748
             E +                 F+ M+ +   L++K +    ++   S  +   + ++  +
Sbjct: 180  TEMEE----------------FVMMKQQ---LQEKEEFISTLQAQLSQTQAEQAAQQVVR 220

Query: 749  EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI 808
            E+  +   E++    E+++  L  + + + T+   +   L     E    L    + +D+
Sbjct: 221  EKDARF--ETQVRLHEDELLQLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277

Query: 809  EKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIK 868
             +QE          E+R+QI  + +++ME +       ++ E +  K  L+  E   ++ 
Sbjct: 278  LQQE------LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL--EVA 329

Query: 869  EKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHL------ 922
            E+   + +  E+ H   E+ +     +   + E     +++KH  E  EK  H+      
Sbjct: 330  ERKLSFHNLQEEMHHLLEQFEQAGQAQA--ELESRYSALEQKHKAEMEEKTSHILSLQKT 387

Query: 923  ----------AESKEKHLMEKKNKQSDNSEYSKSE-KGKNKEKDRELDK---KEKSRDKE 968
                       + +   L++ KN+Q+  S  +  + + + ++K +E+ +   +   +  E
Sbjct: 388  GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447

Query: 969  SINITNSKHIQEEKKSSIVDGNKA---------QHEKPLSLKEKTKDEPLKTPDGKEKDK 1019
            + + T+   +  E   ++ + N A         ++EK   L    + E LK     E +K
Sbjct: 448  TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA----ENEK 503

Query: 1020 KDKDI------DRYKERDKHKDKIQINSLL-KLKSEADKPKPKSSPASKDTRPKEKRLVN 1072
                I      +R  E D+   +I I  +  K  S A++        +   + KE  ++ 
Sbjct: 504  LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL 563

Query: 1073 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIK-DKEKTKHTPT 1131
             ++ +   E       L+ ++  +   E + QKE +++       +K+K   E T     
Sbjct: 564  LEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623

Query: 1132 ESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPR 1191
               N+E +     +   +   + +  + +S     V+ K+    G  S  +   + +  +
Sbjct: 624  LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 1192 SENEK 1196
             E E+
Sbjct: 684  DELER 688



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 185/966 (19%), Positives = 379/966 (39%), Gaps = 174/966 (18%)

Query: 279  QANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKD 338
            +A K   +  D  +++E E+ LK      D+     D     S++   +  NI S  E D
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKE-----DNCSVLKDQLRQMSIHMEELKINI-SRLEHD 2260

Query: 339  SLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHL 398
              I ESK    ++  L   + +   + ++ E ++++ + RH+    Q +  + E+E   L
Sbjct: 2261 KQIWESKA--QTEVQLQQKVCD-TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317

Query: 399  FAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKK 458
              K +      S +  K++   +         E  +QN K S       E   +D+Q  +
Sbjct: 2318 --KDQLTDLSNSLEKCKEQKGNL--EGIIRQQEADIQNSKFSY------EQLETDLQASR 2367

Query: 459  EYVVSGEHKQKGKVKRKLKNQNKNKENQ------ELKQEKEGKENTRITNLTVNTGLDCS 512
            E + S  H++    ++K+ +    KE        EL+Q+ + KE   + NL         
Sbjct: 2368 E-LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD-KEIKELENLL-------- 2417

Query: 513  EKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGS- 571
                EE N              +      K+   +  L E   T +K+E+ +      S 
Sbjct: 2418 -SQEEEENI-------------VLEEENKKAVDKTNQLMETLKT-IKKENIQQKAQLDSF 2462

Query: 572  --SEMSLQPDLVR----YDNTESEFLP---------ESSSVKSCKHKEKSKHQKDFHLEF 616
              S  SLQ D  R    Y   E   L          + ++ ++ K KE+ +  +  H++ 
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS-HMDD 2521

Query: 617  GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY 676
                NAK+ D +     E+ +  +   D + K L + +L+  +  + K+ K  E  KE  
Sbjct: 2522 LNSENAKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE-- 2578

Query: 677  KTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST 736
             ++++ ++L+RS    +E          E +DL   +E   +++ + ++    ++++ + 
Sbjct: 2579 -SEEANEDLRRSFNALQE----------EKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627

Query: 737  KEKHVSKERNFKEERDKIKKESEK-SFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEE 795
               H       K + +++ + S   S  +++I +L+EE                +  +++
Sbjct: 2628 GLYHAQ----LKVKEEEVHRLSALFSSSQKRIAELEEE----------------LVCVQK 2667

Query: 796  SIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
                 + E E  ++K+ KH+          ++  E+ + ++ R   E E+K+    K  K
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK 2727

Query: 856  ------------------DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK-NTAAIKK 896
                               +   +E +D++K K         +  ++G  ++   A + +
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787

Query: 897  TDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN----SEYSKSEKGKNK 952
            T     S E+    H     EK      SK++ L+   ++  D+      +SK+      
Sbjct: 2788 TAFSMNSTEENSLSH----LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843

Query: 953  EKD---RELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEK------ 1003
            E+D    EL+K  KS + +  +         E +S     +  Q+++   LKE       
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2903

Query: 1004 --------TKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
                    T+  PLK    +E   K K     +E  + ++    + L +L+ E      K
Sbjct: 2904 YLQINQEITELHPLKA-QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME------K 2956

Query: 1056 SSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKE-KIKQKEKERLRNRN 1114
            SS    + R KE+ L+            +S KD ++       +E +    + + L+   
Sbjct: 2957 SSWEIHERRMKEQYLM-----------AISDKDQQLSHLQNLIRELRSSSSQTQPLK--- 3002

Query: 1115 CLELKIKDKEKTKHTPTESKN----KELTRSK-SSEVTDAYTKEKQPKDAVSNRSQSVDT 1169
             ++ + +   +T  +P  S+N     EL R++ +  + + + KE + +   SN SQ ++ 
Sbjct: 3003 -VQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061

Query: 1170 KNVMTL 1175
            KN +++
Sbjct: 3062 KNTLSI 3067



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 215/1158 (18%), Positives = 430/1158 (37%), Gaps = 136/1158 (11%)

Query: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPT 779
            L ++S +E N    +  +E+    E+   E +D I+++  +   ++K + L+EER+    
Sbjct: 34   LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQL--QQKDEALQEERKAA-- 89

Query: 780  DKDSEFTSLGMSAIEESIGLHLVEKEIDIE-----KQEKHIKESKEKPEKRSQIKEKDIE 834
              D++   L + A  +   L+   +E+  +       E   +E   K +K S  +E +IE
Sbjct: 90   --DNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147

Query: 835  KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 894
            K++ K  EKE+ I    +++  +    +      E ++      +   KE   S   A +
Sbjct: 148  KIKHKLQEKEELIS-TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206

Query: 895  KKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEK 954
             +T   E++ +++ R+ D  + E +  L E +   L+ + + +++  +  +  + K +E 
Sbjct: 207  SQT-QAEQAAQQVVREKD-ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEH 264

Query: 955  DRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDG 1014
            +  L  + +  D     +T ++  + +  S  +   +A+H    +  E  ++E     + 
Sbjct: 265  EESLVGRAQVVDLLQQELTAAEQ-RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323

Query: 1015 KEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDD 1074
             E +  ++ +        H  + +++ LL+   +A + + +          K K      
Sbjct: 324  MELEVAERKL------SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA----- 372

Query: 1075 LMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESK 1134
             M+     +LSL+    E           Q   + L+++N   L+ K+++  +   T  +
Sbjct: 373  EMEEKTSHILSLQKTGQE----------LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422

Query: 1135 NKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSEN 1194
             ++  + KS E++    +    +   ++++   D  N  T   +     +   R    EN
Sbjct: 423  LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482

Query: 1195 EKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIA- 1253
            EK  L   S+ +  + +  +   + +T          +    + E+    S+   + IA 
Sbjct: 483  EKGALLLSSIELEELKAENEKLSSQITL--------LEAQNRTGEADREVSEISIVDIAN 534

Query: 1254 -KSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSM 1312
             +S +  E   D L            N  S  H     +  + L + E +  I   +  +
Sbjct: 535  KRSSSAEESGQDVL-----------ENTFSQKH---KELSVLLLEMKEAQEEIAFLKLQL 580

Query: 1313 PSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSF-AT 1371
                 E         E  +Q  +  + G+     K +VF     +D   + N  SS  A 
Sbjct: 581  QGKRAEEADH-----EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635

Query: 1372 SPTGASNSKYVSADRNLIKNTAPV---NTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLET 1428
                AS          +  N A V   +T  D    L     +G       +   D LE 
Sbjct: 636  EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG-------QCHQDELER 688

Query: 1429 LSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLS-LRQTELPGNSCAQDPASFMP 1487
            L         S I + E +         K L E A  +S L Q        A + +S   
Sbjct: 689  L--------KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSS--- 737

Query: 1488 PQQPCSFPSQSLSDAESISKHMSLSYVANQEPGI--LQQKNAVQIISSALDTDNESTKD- 1544
                 +F + S    + +S+   LS V      +  L+   A       LD ++++  D 
Sbjct: 738  -----AFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792

Query: 1545 --TENTFVLG-DVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDA-STQL 1600
              TE    L  + +  D  + V  +          E++  +  L S+     S+      
Sbjct: 793  LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852

Query: 1601 NTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMP 1660
               +  SK+   S +  + E   T    +  EK+  +E+L  T +   D  + E++  M 
Sbjct: 853  RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT-IEEKDQQVTEISFSMT 911

Query: 1661 KG--NLNEQ------DPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQ 1712
            +    LNE+      + K   E    L   E+ + +Q    +  +   +    EM   GQ
Sbjct: 912  EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971

Query: 1713 LVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIR 1772
            + K EL+   +  K EN+  QR  + +A  + N+ + +     L  E  +     +  I 
Sbjct: 972  ISKEELQHEFDLLKKENE--QRKRKLQA-ALINRKELLQRVSRLEEELANLKDESKKEIP 1028

Query: 1773 LTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSER 1832
            L+E +  ++   ++ K               +  EK   S        K  EI+ Y  + 
Sbjct: 1029 LSETERGEVEEDKENK---------------EYSEKCVTS--------KCQEIEIYLKQT 1065

Query: 1833 -ANPYFEYLHIRKKIEEK 1849
             +    E  HIRK +EEK
Sbjct: 1066 ISEKEVELQHIRKDLEEK 1083


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 162/896 (18%), Positives = 350/896 (39%), Gaps = 121/896 (13%)

Query: 324  PSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRK 383
            P S +EN++ ET +D    ++  I             Y++  +   E+ +    R +++ 
Sbjct: 135  PESEEENVEWETNRDD--SDNGDI------------NYDYVHELSLEMKRQKIQRELMKL 180

Query: 384  EQ-----------RKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEE 432
            EQ           +KE  PE  ++ L          KS KS K+K S    S+++   + 
Sbjct: 181  EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLR---KSSKSPKRKSSPKSSSASKKDRKT 237

Query: 433  AL---------QNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNK 483
            +          +N K + S    P T +      ++  +  ++K+K KVK +++ + +  
Sbjct: 238  SAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR-- 295

Query: 484  ENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKS 543
                     +GK+  R             E+ RE+ +  +S SP         H S   S
Sbjct: 296  ---------DGKDRGRDF-----------ERQREKRDKPRSTSPAGQ------HHSPISS 329

Query: 544  PKHSCGLSEKQSTPLKQEHT-----KTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVK 598
              HS   S  QS    Q H+     K   SP S + +L P L R     S     S S+ 
Sbjct: 330  RHHS---SSSQSGSSIQRHSPSPRRKRTPSP-SYQRTLTPPLRR-----SASPYPSHSLS 380

Query: 599  SCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHK 658
            S + K+     +    E G   + +   + H    E  + T  K D+E  + ++ + +  
Sbjct: 381  SPQRKQSPPRHRSPMREKGRHDHERTS-QSHDRRHERREDTRGKRDREKDSREEREYEQD 439

Query: 659  EREKEKHKKEIE-----GEKEKYKTKD-----SAKELQRSVEFDREFWKENFFKSDETED 708
            +     H+ + E       ++   T+D      +++++ S E  R++ ++     D  + 
Sbjct: 440  QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREM-RDYSRDTKESRDPRDS 498

Query: 709  LFLNMEHESLTLEKKSKLEKNI---KDDKSTKEKHVSKERNFKEERDKIKKESEKSFREE 765
                  H+    E +    K     ++ +S    H+ +E +  E R++ + ES    R +
Sbjct: 499  RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND 558

Query: 766  KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKR 825
            ++   +     +P           + +   +   H      D  +      E    PE+ 
Sbjct: 559  RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYH------DSWETRSSYPERDRYPERD 612

Query: 826  SQIKEKDIEKMERKTFEKEKKIKHE----------HKSEKDKLDLSECVDKIKEKDKLYS 875
            ++ + +D    ER+  E++++   E          H+   D+L+  E  ++ +  D++  
Sbjct: 613  NRDQARD-SSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE-RRVDRVDD 670

Query: 876  HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
               E+  +   + +     ++  +RE+ RE+   +  + +  +ER     KE+     ++
Sbjct: 671  RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730

Query: 936  KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHE 995
            +  D     + E+ + KE++RE +++E+ R++E       +  + E++ +     + + +
Sbjct: 731  RDHDRERERERERDREKEREREREERERERERER---ERERERERERERARERDKERERQ 787

Query: 996  KPLSLKEKTKDEPLKTPDGKEKDKKDKD-IDRYKERDKHKDKIQINSLLKLKSEADKPKP 1054
            +    K+K +D+  +  +   +D+  +D  D  K + +++++   +     K   +    
Sbjct: 788  RDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPD 847

Query: 1055 KSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1114
              +  S D + ++ RL++  +++    R LS   L  ++  +  +E  K + KE  R   
Sbjct: 848  SDAYNSGDDKNEKHRLLS-QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906

Query: 1115 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTK 1170
              EL    KEK      + +  E+  S      D     +      S+R+   + K
Sbjct: 907  EQEL----KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKK 958



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 143/799 (17%), Positives = 317/799 (39%), Gaps = 138/799 (17%)

Query: 396  THLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQ 455
            +H  +  ++   P   +S  ++  R  +  T  S +   + ++ +       + S  + +
Sbjct: 376  SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE 435

Query: 456  TKKEYVVSGEHKQKGKVK--RKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSE 513
             +++   S +H+   + +  R  ++    ++ +EL+  ++ +++  +         D S 
Sbjct: 436  YEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR--------DYSR 487

Query: 514  KTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP-----LKQEHTKTCL- 567
             T+E  + R S S +D    H +    G+          ++S       L++E ++T + 
Sbjct: 488  DTKESRDPRDSRSTRD---AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544

Query: 568  --SPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIK 625
              S   S   ++ D +         LPE  S +  +  +   H  + +     ++ +   
Sbjct: 545  NESRNESRSEIRNDRMGRSRGRVPELPEKGS-RGSRGSQIDSHSSNSNYHDSWETRSSYP 603

Query: 626  DEDHSPTFENSDCTL----------------KKMDKEGKTLKKHKLKHKEREKEKHKKEI 669
            + D  P  +N D                   ++ D+   +  +H+ ++ E E+++ ++E 
Sbjct: 604  ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663

Query: 670  EGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKN 729
              ++   +  + A+E  R  E DRE  +E               E E             
Sbjct: 664  RVDRVDDRRDERARERDRERERDRERERER--------------ERE------------- 696

Query: 730  IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
             +D +  KE+ + +ER  + ER++   E E+    ++ +D   ERE              
Sbjct: 697  -RDREREKERELERERARERERER---EKERDRERDRDRDHDRERER------------- 739

Query: 790  MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
                         E+E D EK+ +  +E +E+  +R + +E++ E+   +  E++K+ + 
Sbjct: 740  -------------ERERDREKEREREREERERERERERERERERERERERARERDKERER 786

Query: 850  EHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREK 906
            +   E   K + D  E  ++I+E       H E+  K+  +++ + + +++  R +    
Sbjct: 787  QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846

Query: 907  MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRD 966
                ++    + E+H   S+   +  ++++    S  ++  +G+ KE+DR+ ++KE SR 
Sbjct: 847  DSDAYNSGDDKNEKHRLLSQV--VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRR 904

Query: 967  KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD-------EPLKTPD-GKEKD 1018
             E   +        ++K S VD  + Q E   S + + +D       E  +T D   +++
Sbjct: 905  YEEQEL--------KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDEN 956

Query: 1019 KKDKDIDRYKERDKHKDKIQI--NSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLM 1076
            KK   I +   + K +D + I   ++     +     PK     K    K K+   D   
Sbjct: 957  KKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDS-- 1014

Query: 1077 QTSFERMLSLKDLEIEQWHKKHK----EKIKQKEK--ERLRNRNCLELKIKDKEKTKHTP 1130
                     + D E  Q  KK +      I  KE+  E    +N +   ++D +K + T 
Sbjct: 1015 --------DISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI---LEDSQKKEDTA 1063

Query: 1131 TESKNKELTRSKSSEVTDA 1149
                + E    + +EVT+A
Sbjct: 1064 FSDWSDEDVPDR-TEVTEA 1081



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 101/543 (18%), Positives = 204/543 (37%), Gaps = 63/543 (11%)

Query: 728  KNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDS--EF 785
            KN + D  T+ +    +RN +E    ++KES +    EK +D+K  +E  P  ++   E+
Sbjct: 90   KNKRQDVDTEPQ----KRNTEESSSPVRKESSRGRHREK-EDIKITKERTPESEEENVEW 144

Query: 786  TSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEK 845
             +    +    I    V  E+ +E + + I              ++++ K+E++  EK +
Sbjct: 145  ETNRDDSDNGDINYDYVH-ELSLEMKRQKI--------------QRELMKLEQENMEKRE 189

Query: 846  K--IKHEHKSE--KDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK--TDD 899
            +  IK E   E  + KL  S  + K  +  K  S  + K     +K + T+A+     D 
Sbjct: 190  EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKS--SPKSSSASKKDRKTSAVSSPLLDQ 247

Query: 900  REKSREKMDRKHDKEKPEKERHLAE--SKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRE 957
            +  S+    +K     P     + E  +  K   EK   +    E ++  K + ++ +R+
Sbjct: 248  QRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQ 307

Query: 958  LDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKT------------- 1004
             +K++K R        +S        SS   G+  Q   P   +++T             
Sbjct: 308  REKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPL 367

Query: 1005 -------KDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSS 1057
                       L +P  K+   + +   R K R  H+   Q +     + E  + K    
Sbjct: 368  RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK---R 424

Query: 1058 PASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLE 1117
               KD+R +E+    D             +D    +  +  +++ + ++   +R+   + 
Sbjct: 425  DREKDSR-EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR 483

Query: 1118 LKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGK 1177
               +D ++++        ++    +  E  D + KE    D     S+S    ++     
Sbjct: 484  DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKE----DTYPEESRSYGRNHLREESS 539

Query: 1178 SSFVSDNSLNRSPRSE--NEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFML 1235
             + + + S N S RSE  N++ G S   V  +    S  S  + + +      Y   +  
Sbjct: 540  RTEIRNESRNES-RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598

Query: 1236 ESS 1238
             SS
Sbjct: 599  RSS 601



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 149/827 (18%), Positives = 311/827 (37%), Gaps = 114/827 (13%)

Query: 360  EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 419
            E E + + D E ++  D      +E+ ++ E E E+     ++E+    +  + ++++  
Sbjct: 716  EREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERE 775

Query: 420  RVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQ 479
            R      E   +   ++K          +    D + K+E +    + + G  +RK K +
Sbjct: 776  RARERDKERERQRDWEDK----------DKGRDDRREKREEIREDRNPRDGHDERKSKKR 825

Query: 480  NKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHIS 539
             +N+ +   +Q  + +      +   N+G D +EK R      +   P++  SL      
Sbjct: 826  YRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRL---LSQVVRPQESRSL------ 876

Query: 540  TGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKS 599
               SP H   L+E +    K+E  K    P   E S      RY+  E E   + SSV  
Sbjct: 877  ---SPSH---LTEDRQGRWKEEDRK----PERKESSR-----RYE--EQELKEKVSSV-- 917

Query: 600  CKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKE 659
                +K + Q +  LE        I     S   E SD    +  K+ K  KK   K KE
Sbjct: 918  ----DKQREQTEI-LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972

Query: 660  REKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESL 718
             +    +  IE   E  +     K + ++S+E  R+  K +   SDE          E+ 
Sbjct: 973  DDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDE----------EAA 1022

Query: 719  TLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIP 778
               KK +  +      +TKE+ V          +  +K+ + +F +   +D+ +  E   
Sbjct: 1023 QQSKKKRGPRT--PPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080

Query: 779  TDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE---- 834
             +  +  T+ G +    S  L                  +       +      I     
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS 1140

Query: 835  ----KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKI---------KEKDKLYSHHTEKC 881
                     TF  E   +  H++  +K++      +          K    L S+ + + 
Sbjct: 1141 ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS 1200

Query: 882  HKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
            H  G  +S +  +  ++ D +  R+++     +++          K K L     ++S  
Sbjct: 1201 HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR---------EKTKSLEITGERKSRI 1251

Query: 941  SEYSKSEKGKNKEKDRELDKKEKSR--DKESINITNSKHIQEEKKSSIVDGNKAQHEKPL 998
             +  + E  ++   DR+  +   SR    ES    +S+    + +  + + ++ +H++  
Sbjct: 1252 DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRE- 1310

Query: 999  SLKEKTKDEPLKTPDGKEKDK---KDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPK 1055
              +E+ + +  +    ++ DK   +++D DR +ER++ +             E DK    
Sbjct: 1311 --RERERRDTRQREWDRDADKDWPRNRDRDRLRERERER-------------ERDK---- 1351

Query: 1056 SSPASKDTRPKEKRLVNDDL-MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRN 1114
                 +D   + +RL++D +      +R  + +  +IE   K+ + K++ + +  L + +
Sbjct: 1352 ----RRDLDRERERLISDSVERDRDRDRDRTFESSQIES-VKRCEAKLEGEHERDLESTS 1406

Query: 1115 CLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVS 1161
               L +  +   K   +    +E  +S+ +E  +A   E +  DA S
Sbjct: 1407 RDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHS 1453



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 123/676 (18%), Positives = 255/676 (37%), Gaps = 90/676 (13%)

Query: 317  EEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMID 376
            +E++S++PS + E+     +++    E K+   S+      L E     D   E  ++++
Sbjct: 871  QESRSLSPSHLTEDRQGRWKEEDRKPERKE--SSRRYEEQELKEKVSSVDKQREQTEILE 928

Query: 377  DRHILRKE----QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTE--SSD 430
               +  ++     + E+   +++ H   K++     K  K KK+    +   + E  S D
Sbjct: 929  SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988

Query: 431  EEALQNKKISTSCSVIPETSNS--DMQTKKEYVVSGEHKQKGK------VKRKLKNQNKN 482
             +    KK     S+  +   S  D     E       K++G        K +L      
Sbjct: 989  GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048

Query: 483  KENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGK 542
            K    + ++ + KE+T  ++ +     D +E T  E     + +    T   L  +    
Sbjct: 1049 KNG--ILEDSQKKEDTAFSDWSDEDVPDRTEVT--EAEHTATATTPGSTPSPLSSLLPPP 1104

Query: 543  SPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKH 602
             P  +   +   +T L         S  +S +++       + T + F  E S  K   H
Sbjct: 1105 PPVATATATTVPAT-LAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKC--H 1161

Query: 603  KEKSKHQKDFHLEFGEKSNAKIKDEDHSPTF-----------------ENSDCTLKKMDK 645
            + + +  +  H+   +  + K  D+  S +                   N        D+
Sbjct: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQ 1221

Query: 646  EGKTLKKHKLKHKEREKEKHKK-EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704
             G+   K  L    R++EK K  EI GE++    +    E  RS   DR+  + +  +  
Sbjct: 1222 SGR---KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRS 1278

Query: 705  ETEDLFLNMEHESLTLEKKSKLEKNIK---DDKSTKEKHVSKERNFKEERDKI------- 754
              E     +   S + + + +L++  +   D +  +E+  +++R +  + DK        
Sbjct: 1279 SPES-DRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR 1337

Query: 755  --KKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE 812
               +E E+    +K +DL  ERE + +D                     VE++ D ++ +
Sbjct: 1338 DRLRERERERERDKRRDLDRERERLISDS--------------------VERDRDRDR-D 1376

Query: 813  KHIKESKEKPEKRSQIK-----EKDIEKMERKT--FEKEKKIKH----EHKSEKDKLDLS 861
            +  + S+ +  KR + K     E+D+E   R +   +KE+  K     +   E +K + +
Sbjct: 1377 RTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERT 1436

Query: 862  ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH 921
            E ++   ++ KL   H+      GE  +  +  +  +      EK + + D+EK      
Sbjct: 1437 ESLEAGDDESKLDDAHS-LGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLD 1495

Query: 922  LAESKEKHLMEKKNKQ 937
            + +     LM K  K+
Sbjct: 1496 VIDVDWSGLMPKHPKE 1511



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 40/212 (18%), Positives = 90/212 (42%), Gaps = 18/212 (8%)

Query: 861  SECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKS--REKMDRKHDKEKPE 917
            ++C + +K  + LY +     H    + K  ++  +++ +R     RE+M  K      E
Sbjct: 40   TQCRNWLKTGNCLYGNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTE 99

Query: 918  KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 977
             ++            +  ++S +    +S +G+++EK+     KE++ + E  N+    +
Sbjct: 100  PQK------------RNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147

Query: 978  IQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI 1037
              +     I       HE  L +K +     L   + +  +K+++ I + KE      + 
Sbjct: 148  RDDSDNGDI--NYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK-KEVSPEVVRS 204

Query: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKR 1069
            +++    L+  +  PK KSSP S     K+++
Sbjct: 205  KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 39/199 (19%), Positives = 80/199 (40%), Gaps = 27/199 (13%)

Query: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1059
            +K K +D   + P  +  ++    + +   R +H++K  I    +   E+++   +    
Sbjct: 89   MKNKRQDVDTE-PQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETN 147

Query: 1060 SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELK 1119
              D+   +   +N D +           +L +E   +K + ++ + E+E +  R  + +K
Sbjct: 148  RDDSDNGD---INYDYVH----------ELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194

Query: 1120 IKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSS 1179
                        +  + E+ RSK S         K PK   S +S S   K+  T   SS
Sbjct: 195  ------------KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSS 242

Query: 1180 FVSDNSLNRSPRSENEKPG 1198
             + D   N S  ++++K G
Sbjct: 243  PLLDQQRN-SKTNQSKKKG 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.124    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,005,312
Number of Sequences: 37866
Number of extensions: 4293264
Number of successful extensions: 51086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 1595
Number of HSP's that attempted gapping in prelim test: 15398
Number of HSP's gapped (non-prelim): 15873
length of query: 2062
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1944
effective length of database: 13,779,330
effective search space: 26787017520
effective search space used: 26787017520
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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