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Search of human proteins with 13489054
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 803 0.0
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 637 0.0
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 254 1e-67
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 238 5e-63
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 207 1e-53
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 205 5e-53
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 205 5e-53
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 203 3e-52
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 202 6e-52
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 170 2e-42
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 164 1e-40
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 160 1e-39
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 147 2e-35
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 145 6e-35
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 145 6e-35
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 144 1e-34
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 134 1e-31
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 132 4e-31
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 125 7e-29
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 124 1e-28
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 124 1e-28
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 121 1e-27
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 121 1e-27
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 121 1e-27
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 118 1e-26
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 118 1e-26
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 118 1e-26
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 118 1e-26
gi|32483399 p21-activated kinase 2 [Homo sapiens] 117 1e-26
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 117 1e-26
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 803 bits (2073), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 60
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
Sbjct: 1 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 60
Query: 61 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 120
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
Sbjct: 61 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 120
Query: 121 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 180
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
Sbjct: 121 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 180
Query: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ 240
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
Sbjct: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ 240
Query: 241 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 300
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
Sbjct: 241 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 300
Query: 301 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 360
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
Sbjct: 301 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 360
Query: 361 KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 400
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
Sbjct: 361 KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 400
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 637 bits (1644), Expect = 0.0
Identities = 319/398 (80%), Positives = 349/398 (87%), Gaps = 7/398 (1%)
Query: 2 LARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQK 61
+ ++KP + +NP +G + ++E NL LQKKLEELELDEQQ+KRLEAFLTQK
Sbjct: 1 MPKKKPT--PIQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQK 57
Query: 62 AKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV 121
KVGELKDDDFE+ISELGAGNGGVV KV H+PSGL+MARKLIHLEIKPAIRNQIIRELQV
Sbjct: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117
Query: 122 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGL 181
LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK+A RIPE+ILGKVSIAV++GL
Sbjct: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177
Query: 182 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG 241
YLREKH+IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM+PERLQG
Sbjct: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237
Query: 242 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPP 301
THYSVQSDIWSMGLSLVE+AVGRYPIPPPDAKELE +FG V EG+ PRPR P
Sbjct: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPRPRTP 293
Query: 302 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLK 361
GRP+S +GMDSRP MAIFELLDYIVNEPPPKLP+GVF+ +FQ+FVNKCLIKNPAERADLK
Sbjct: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353
Query: 362 MLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTA 399
L H FIKRS+ EEVDFAGWLC T+ LNQP TPT A
Sbjct: 354 QLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAA 391
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 254 bits (649), Expect = 1e-67
Identities = 142/353 (40%), Positives = 208/353 (58%), Gaps = 47/353 (13%)
Query: 46 LDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL 105
L K+ A L + G++ + D LG GNGG V K H PSG I+A K+I L
Sbjct: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
Query: 106 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI 165
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD +++
Sbjct: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVY----RKM 255
Query: 166 PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 225
PE +LG++++AV++GL YL +I+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
Query: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVD 285
++VGT +YMAPER+ G Y + SD+WS+G+S +ELA+GR+P P +
Sbjct: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQ--------------IQ 360
Query: 286 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 345
+G S+ P +LL IV+E P LP G F+ F F
Sbjct: 361 KNQG---SLMP----------------------LQLLQCIVDEDSPVLPVGEFSEPFVHF 395
Query: 346 VNKCLIKNPAERADLKMLTNHTFIKR-SEVEEVDFAGWLCKTL--RLNQPGTP 395
+ +C+ K P ER + L H FI + ++ + W+C+ L R +Q G P
Sbjct: 396 ITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 448
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 238 bits (608), Expect = 5e-63
Identities = 134/353 (37%), Positives = 198/353 (56%), Gaps = 57/353 (16%)
Query: 46 LDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL 105
L K+ A L + G++ + D LG GNGG V K H PSG I+A K+I L
Sbjct: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
Query: 106 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI 165
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD +++
Sbjct: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVY----RKM 255
Query: 166 PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 225
PE +LG++++AV++GL YL +I+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
Query: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVD 285
++VGT +YMAPER+ G Y + SD+WS+G+S +E+ + + P
Sbjct: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP---------------- 358
Query: 286 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 345
+LL IV+E P LP G F+ F F
Sbjct: 359 ---------------------------------LQLLQCIVDEDSPVLPVGEFSEPFVHF 385
Query: 346 VNKCLIKNPAERADLKMLTNHTFIKR-SEVEEVDFAGWLCKTL--RLNQPGTP 395
+ +C+ K P ER + L H FI + ++ + W+C+ L R +Q G P
Sbjct: 386 ITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 438
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 207 bits (528), Expect = 1e-53
Identities = 121/328 (36%), Positives = 183/328 (55%), Gaps = 56/328 (17%)
Query: 66 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 124
E+K DD E I ELG G GVV K++H PSG IMA K I + + +++ +L + +
Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106
Query: 125 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKEAKRIPEEILGKVSIAVLRG 180
+ P+ V FYGA + +G++ ICME MD SLD QV+ + + IPE+ILGK+++++++
Sbjct: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165
Query: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER- 238
L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YMAPER
Sbjct: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225
Query: 239 ---LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
L YSV+SDIWS+G++++ELA+ R+P +G P
Sbjct: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDS---------WGTP------------- 263
Query: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
F+ L +V EP P+LP F+ +F +F ++CL KN
Sbjct: 264 -----------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300
Query: 356 ERADLKMLTNHTFIKRSEVEEVDFAGWL 383
ER L H F E + D A ++
Sbjct: 301 ERPTYPELMQHPFFTLHESKGTDVASFV 328
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 205 bits (522), Expect = 5e-53
Identities = 122/341 (35%), Positives = 187/341 (54%), Gaps = 56/341 (16%)
Query: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116
F+T + E++ DD ISELG G GVV KV+H SG IMA K I + + +++
Sbjct: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
Query: 117 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILG 171
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG
Sbjct: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 138
Query: 172 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 230
+++++++R L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 139 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 198
Query: 231 RSYMAPER----LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDG 286
+ YMAPER L Y+V+SD+WS+G++++E+A+ R+P +G P
Sbjct: 199 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES---------WGTP---- 245
Query: 287 EEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFV 346
F+ L +V EP P+LP F+P+F +F
Sbjct: 246 --------------------------------FQQLKQVVEEPSPQLPADRFSPEFVDFT 273
Query: 347 NKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
+CL KNPAER L H F + ++ D A ++ + L
Sbjct: 274 AQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 314
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 205 bits (522), Expect = 5e-53
Identities = 122/341 (35%), Positives = 187/341 (54%), Gaps = 56/341 (16%)
Query: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116
F+T + E++ DD ISELG G GVV KV+H SG IMA K I + + +++
Sbjct: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
Query: 117 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILG 171
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG
Sbjct: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 167
Query: 172 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 230
+++++++R L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 168 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 227
Query: 231 RSYMAPER----LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDG 286
+ YMAPER L Y+V+SD+WS+G++++E+A+ R+P +G P
Sbjct: 228 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES---------WGTP---- 274
Query: 287 EEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFV 346
F+ L +V EP P+LP F+P+F +F
Sbjct: 275 --------------------------------FQQLKQVVEEPSPQLPADRFSPEFVDFT 302
Query: 347 NKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 387
+CL KNPAER L H F + ++ D A ++ + L
Sbjct: 303 AQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEIL 343
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 203 bits (516), Expect = 3e-52
Identities = 127/341 (37%), Positives = 182/341 (53%), Gaps = 61/341 (17%)
Query: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHECNSP 128
+D + + E+G G G V K+ H+PSG IMA K I + + Q++ +L V + + P
Sbjct: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
Query: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR-----IPEEILGKVSIAVLRGLAY 183
YIV FYGA + +G+ ICME M S D+ K IPEEILGK+++A ++ L +
Sbjct: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
Query: 184 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMAPERLQGT 242
L+E +I+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YMAPER+ +
Sbjct: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
Query: 243 ----HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRP 298
Y V+SD+WS+G++L ELA GR+P P +
Sbjct: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--------------------------- 311
Query: 299 RPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNG---VFTPDFQEFVNKCLIKNPA 355
++F+ L +V PP+L N F+P F FVN CL K+ +
Sbjct: 312 ------------------SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDES 353
Query: 356 ERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPT 396
+R K L H FI E V+ A ++CK L P TP+
Sbjct: 354 KRPKYKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 393
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 202 bits (513), Expect = 6e-52
Identities = 125/358 (34%), Positives = 195/358 (54%), Gaps = 63/358 (17%)
Query: 39 KKLEELELDE--QQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGL 96
+ +E +E+D+ Q+ + +LT + + + +D E + E+G+G G V K++ R +G
Sbjct: 85 RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH 144
Query: 97 IMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEHMDGG 153
++A K + +I+ +L V+ H+C PYIV +G F ++ ++ I ME M G
Sbjct: 145 VIAVKQMRRSGNKEENKRILMDLDVVLKSHDC--PYIVQCFGTFITNTDVFIAMELM--G 200
Query: 154 SLDQVLKEAKR--IPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLC 211
+ + LK+ + IPE ILGK+++A+++ L YL+EKH ++HRDVKPSNIL++ RG+IKLC
Sbjct: 201 TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLC 260
Query: 212 DFGVSGQLIDSMANS-FVGTRSYMAPERLQ-----GTHYSVQSDIWSMGLSLVELAVGRY 265
DFG+SG+L+DS A + G +YMAPER+ Y +++D+WS+G+SLVELA G++
Sbjct: 261 DFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF 320
Query: 266 PIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYI 325
P + FE+L +
Sbjct: 321 PY---------------------------------------------KNCKTDFEVLTKV 335
Query: 326 VNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGW 382
+ E PP LP + F+ DFQ FV CL K+ +R L H+FIKR E EVD A W
Sbjct: 336 LQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASW 393
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 170 bits (431), Expect = 2e-42
Identities = 106/324 (32%), Positives = 173/324 (53%), Gaps = 60/324 (18%)
Query: 61 KAKVGELKDDD--------FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIR 112
K+K+ +L +D F+ + +LG G+ G V K H+ SG ++A K + +E +
Sbjct: 8 KSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDL 64
Query: 113 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-EAKRIPEEILG 171
+II+E+ ++ +C+SPY+V +YG+++ + ++ I ME+ GS+ +++ K + E+ +
Sbjct: 65 QEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIA 124
Query: 172 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVG 229
+ + L+GL YL +I HRD+K NIL+N+ G KL DFGV+GQL D+MA N+ +G
Sbjct: 125 TILKSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIG 183
Query: 230 TRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEG 289
T +MAPE +Q Y+ +DIWS+G++ +E+A G+ PP A
Sbjct: 184 TPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK----PPYA----------------- 222
Query: 290 EPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKC 349
D P AIF + N PP +++ DF +FV KC
Sbjct: 223 ---------------------DIHPMRAIFMI---PTNPPPTFRKPELWSDDFTDFVKKC 258
Query: 350 LIKNPAERADLKMLTNHTFIKRSE 373
L+KNP +RA L H FIK ++
Sbjct: 259 LVKNPEQRATATQLLQHPFIKNAK 282
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 164 bits (416), Expect = 1e-40
Identities = 88/202 (43%), Positives = 132/202 (65%), Gaps = 11/202 (5%)
Query: 66 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 124
E++ DD I ELG G GVV KV+H SG IMA KLI + + +++ +L + +
Sbjct: 63 EVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINMRT 122
Query: 125 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILGKVSIAVLRG 180
+ Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG+++++++R
Sbjct: 123 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 181
Query: 181 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER- 238
L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A G + YMAPER
Sbjct: 182 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERI 241
Query: 239 ---LQGTHYSVQSDIWSMGLSL 257
L Y+V+SD+WS+G+++
Sbjct: 242 NPELNQKGYNVKSDVWSLGITM 263
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 160 bits (406), Expect = 1e-39
Identities = 102/328 (31%), Positives = 175/328 (53%), Gaps = 58/328 (17%)
Query: 49 QQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIK 108
Q KK E LT++ ++ F+ + +LG G+ G V K H+ +G I+A K + +E
Sbjct: 13 QLKKLDEDSLTKQP------EEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE-- 64
Query: 109 PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-EAKRIPE 167
+ +II+E+ ++ +C+SP++V +YG+++ + ++ I ME+ GS+ +++ K + E
Sbjct: 65 -SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTE 123
Query: 168 EILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--N 225
+ + + + L+GL YL +I HRD+K NIL+N+ G KL DFGV+GQL D+MA N
Sbjct: 124 DEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN 182
Query: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVD 285
+ +GT +MAPE +Q Y+ +DIWS+G++ +E+A G+ PP A
Sbjct: 183 TVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK----PPYA------------- 225
Query: 286 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 345
D P AIF + N PP +++ +F +F
Sbjct: 226 -------------------------DIHPMRAIFMI---PTNPPPTFRKPELWSDNFTDF 257
Query: 346 VNKCLIKNPAERADLKMLTNHTFIKRSE 373
V +CL+K+P +RA L H F++ ++
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFVRSAK 285
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 147 bits (371), Expect = 2e-35
Identities = 101/320 (31%), Positives = 160/320 (50%), Gaps = 53/320 (16%)
Query: 54 LEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRN 113
L F Q ++V ++ F ++ +G G+ G V K + ++A K+I LE
Sbjct: 4 LRGFANQHSRVDP--EELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 61
Query: 114 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKV 173
I +E+ VL +C+SPYI ++G++ ++ I ME++ GGS +LK + E + +
Sbjct: 62 DIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGP-LEETYIATI 120
Query: 174 SIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR 231
+L+GL YL + +I HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT
Sbjct: 121 LREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 179
Query: 232 SYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEP 291
+MAPE ++ + Y ++DIWS+G++ +ELA G PP++
Sbjct: 180 FWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNS------------------- 216
Query: 292 HSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLI 351
D P +F I PP L G + F+EFV CL
Sbjct: 217 -------------------DLHPMRVLF----LIPKNSPPTL-EGQHSKPFKEFVEACLN 252
Query: 352 KNPAERADLKMLTNHTFIKR 371
K+P R K L H FI R
Sbjct: 253 KDPRFRPTAKELLKHKFITR 272
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 145 bits (366), Expect = 6e-35
Identities = 98/303 (32%), Positives = 153/303 (50%), Gaps = 51/303 (16%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 131
F ++ ++G G+ G V K + ++A K+I LE I +E+ VL +C+SPY+
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 132 GFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIM 191
+YG++ D ++ I ME++ GGS +L E + E + + +L+GL YL + +I
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI- 141
Query: 192 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQGTHYSVQSD 249
HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +MAPE ++ + Y ++D
Sbjct: 142 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 201
Query: 250 IWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHG 309
IWS+G++ +ELA G PHS
Sbjct: 202 IWSLGITAIELARGE-------------------------PPHS---------------- 220
Query: 310 MDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI 369
+ P +F I PP L G ++ +EFV CL K P+ R K L H FI
Sbjct: 221 -ELHPMKVLF----LIPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
Query: 370 KRS 372
R+
Sbjct: 275 LRN 277
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 145 bits (366), Expect = 6e-35
Identities = 98/303 (32%), Positives = 153/303 (50%), Gaps = 51/303 (16%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 131
F ++ ++G G+ G V K + ++A K+I LE I +E+ VL +C+SPY+
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 132 GFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIM 191
+YG++ D ++ I ME++ GGS +L E + E + + +L+GL YL + +I
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI- 153
Query: 192 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQGTHYSVQSD 249
HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +MAPE ++ + Y ++D
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 213
Query: 250 IWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHG 309
IWS+G++ +ELA G PHS
Sbjct: 214 IWSLGITAIELARGE-------------------------PPHS---------------- 232
Query: 310 MDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI 369
+ P +F I PP L G ++ +EFV CL K P+ R K L H FI
Sbjct: 233 -ELHPMKVLF----LIPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
Query: 370 KRS 372
R+
Sbjct: 287 LRN 289
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 144 bits (364), Expect = 1e-34
Identities = 97/303 (32%), Positives = 155/303 (51%), Gaps = 51/303 (16%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 131
F ++ +G G+ G V K + ++A K+I LE I +E+ VL +C+S Y+
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 132 GFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIM 191
+YG++ ++ I ME++ GGS +L+ A E + + +L+GL YL + +I
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQIATMLKEILKGLDYLHSEKKI- 141
Query: 192 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQGTHYSVQSD 249
HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT +MAPE +Q + Y ++D
Sbjct: 142 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 201
Query: 250 IWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHG 309
IWS+G++ +ELA G PP++
Sbjct: 202 IWSLGITAIELAKGE----PPNS------------------------------------- 220
Query: 310 MDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI 369
D P +F I PP L G FT F+EF++ CL K+P+ R K L H FI
Sbjct: 221 -DMHPMRVLF----LIPKNNPPTLV-GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274
Query: 370 KRS 372
++
Sbjct: 275 VKN 277
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 134 bits (338), Expect = 1e-31
Identities = 91/306 (29%), Positives = 155/306 (50%), Gaps = 55/306 (17%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 131
+E + ELG G G V K +++ +G + A K+I + + + + I+ E+++L C+ PYIV
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIV 94
Query: 132 GFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR-IPEEILGKVSIAVLRGLAYLREKHQI 190
GA+Y DG++ I +E GG++D ++ E R + E + V +L L +L K +I
Sbjct: 95 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK-RI 153
Query: 191 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAP-----ERLQGTH 243
+HRD+K N+L+ G+I+L DFGVS + + ++ +SF+GT +MAP E ++ T
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 244 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGR 303
Y ++DIWS+G++L+E+A I PP H ++P
Sbjct: 214 YDYKADIWSLGITLIEMA----QIEPPH--------------------HELNP------- 242
Query: 304 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKML 363
+ LL ++PP L ++ +F++F+ L KNP R L
Sbjct: 243 --------------MRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQL 288
Query: 364 TNHTFI 369
H F+
Sbjct: 289 LEHPFV 294
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 132 bits (333), Expect = 4e-31
Identities = 65/138 (47%), Positives = 98/138 (71%), Gaps = 10/138 (7%)
Query: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILGKVSIAVLRGLAYL 184
Y V FYGA + +G++ ICME MD SLD+ VL + IPE+ILG+++++++R L +L
Sbjct: 14 YTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 72
Query: 185 REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER----L 239
K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YMAPER L
Sbjct: 73 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 132
Query: 240 QGTHYSVQSDIWSMGLSL 257
Y+V+SD+WS+G+++
Sbjct: 133 NQKGYNVKSDVWSLGITM 150
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 125 bits (314), Expect = 7e-29
Identities = 96/309 (31%), Positives = 148/309 (47%), Gaps = 58/309 (18%)
Query: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIR-ELQVLHECNSP 128
+DFE I +G+G G V K ++ +G + A K+I LE P +++ E+ ++ +C P
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKH 188
IV ++G++ ++ ICME GGSL + + E + VS L+GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131
Query: 189 QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAP-----ERLQG 241
+ MHRD+K +NIL+ G +KL DFGVS Q+ ++A SF+GT +MAP ER G
Sbjct: 132 K-MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 242 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPP 301
Y+ D+W++G++ +ELA + PP
Sbjct: 191 --YNQLCDLWAVGITAIELA----ELQPP------------------------------- 213
Query: 302 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADL 360
D P A+F + N PPKL + + ++ F FV L KNP +R
Sbjct: 214 -------MFDLHPMRALFLMTK--SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTA 264
Query: 361 KMLTNHTFI 369
+ L H F+
Sbjct: 265 EKLLQHPFV 273
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 124 bits (312), Expect = 1e-28
Identities = 94/294 (31%), Positives = 154/294 (52%), Gaps = 37/294 (12%)
Query: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 129
D ++ + LG G G V K + + SG ++A K++ +E + + + +E+ +L C
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 73
Query: 130 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ 189
IV ++G++ ++ ICME GSL + + + E + V VL+GLAYL + +
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMAPE----RLQGTH 243
I HRD+K +NIL+N GE++L DFG+S Q+ ++A SF+GT +MAPE L+G
Sbjct: 134 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG-G 191
Query: 244 YSVQSDIWSMGLSLVELAVGRYPIPPP--DAKELEAIF------GRPVVDGEEGEPHSI- 294
Y+ DIWS+G++ +ELA + PP D L +F +P E+G+ +
Sbjct: 192 YNELCDIWSLGITAIELA----ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 247
Query: 295 ----------SPRPRPPGRPVSGHGMDSRPAM---AIFELLDYIVNEPPPKLPN 335
SP+ RP + H + S+P + I +LLD + N P K P+
Sbjct: 248 HNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN--PGKGPS 299
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 124 bits (312), Expect = 1e-28
Identities = 94/294 (31%), Positives = 154/294 (52%), Gaps = 37/294 (12%)
Query: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 129
D ++ + LG G G V K + + SG ++A K++ +E + + + +E+ +L C
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 73
Query: 130 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ 189
IV ++G++ ++ ICME GSL + + + E + V VL+GLAYL + +
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMAPE----RLQGTH 243
I HRD+K +NIL+N GE++L DFG+S Q+ ++A SF+GT +MAPE L+G
Sbjct: 134 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG-G 191
Query: 244 YSVQSDIWSMGLSLVELAVGRYPIPPP--DAKELEAIF------GRPVVDGEEGEPHSI- 294
Y+ DIWS+G++ +ELA + PP D L +F +P E+G+ +
Sbjct: 192 YNELCDIWSLGITAIELA----ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 247
Query: 295 ----------SPRPRPPGRPVSGHGMDSRPAM---AIFELLDYIVNEPPPKLPN 335
SP+ RP + H + S+P + I +LLD + N P K P+
Sbjct: 248 HNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN--PGKGPS 299
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 121 bits (304), Expect = 1e-27
Identities = 93/305 (30%), Positives = 146/305 (47%), Gaps = 52/305 (17%)
Query: 71 DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 130
D+E + +G+G G V K ++ +G + A K+I LE + I +E+ ++ EC I
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNI 77
Query: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQI 190
V ++G++ S ++ ICME+ GGSL + + E + V L+GLAYL K +
Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK- 136
Query: 191 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL---QGTHYS 245
MHRD+K +NIL+ G++KL DFGV+ ++ ++A SF+GT +MAPE + Y+
Sbjct: 137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYN 196
Query: 246 VQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 305
DIW++G++ +EL + PP
Sbjct: 197 QLCDIWAVGITAIELG----ELQPP----------------------------------- 217
Query: 306 SGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLT 364
D P A+F L N PPKL + ++ F FV L KNP +R + L
Sbjct: 218 ---MFDLHPMRALF--LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLL 272
Query: 365 NHTFI 369
HTF+
Sbjct: 273 THTFV 277
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 121 bits (304), Expect = 1e-27
Identities = 93/305 (30%), Positives = 146/305 (47%), Gaps = 52/305 (17%)
Query: 71 DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 130
D+E + +G+G G V K ++ +G + A K+I LE + I +E+ ++ EC I
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNI 77
Query: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQI 190
V ++G++ S ++ ICME+ GGSL + + E + V L+GLAYL K +
Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK- 136
Query: 191 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL---QGTHYS 245
MHRD+K +NIL+ G++KL DFGV+ ++ ++A SF+GT +MAPE + Y+
Sbjct: 137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYN 196
Query: 246 VQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 305
DIW++G++ +EL + PP
Sbjct: 197 QLCDIWAVGITAIELG----ELQPP----------------------------------- 217
Query: 306 SGHGMDSRPAMAIFELLDYIVNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLT 364
D P A+F L N PPKL + ++ F FV L KNP +R + L
Sbjct: 218 ---MFDLHPMRALF--LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLL 272
Query: 365 NHTFI 369
HTF+
Sbjct: 273 THTFV 277
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 121 bits (304), Expect = 1e-27
Identities = 93/313 (29%), Positives = 152/313 (48%), Gaps = 56/313 (17%)
Query: 66 ELKDDDF-ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE 124
+L +DF E I ELG G G V K Q++ + ++ A K+I + + + + ++ E+ +L
Sbjct: 27 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 125 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR-IPEEILGKVSIAVLRGLAY 183
C+ P IV AFY + + I +E GG++D V+ E +R + E + V L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 184 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERL-- 239
L + ++I+HRD+K NIL G+IKL DFGVS + ++ +SF+GT +MAPE +
Sbjct: 146 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 204
Query: 240 ---QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISP 296
+ Y ++D+WS+G++L+E+A I PP H ++P
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA----EIEPPH--------------------HELNP 240
Query: 297 RPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAE 356
+ LL +EPP ++ +F++F+ KCL KN
Sbjct: 241 ---------------------MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDA 279
Query: 357 RADLKMLTNHTFI 369
R L H F+
Sbjct: 280 RWTTSQLLQHPFV 292
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 118 bits (295), Expect = 1e-26
Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 65/320 (20%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 130
FE + +G G G V K +H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 131 VGFYGAFY------SDGEISICMEHMDGGSLDQVLKEAK--RIPEEILGKVSIAVLRGLA 182
+YGAF +D ++ + ME GS+ ++K K + E+ + + +LRGLA
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL- 239
+L H+++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +MAPE +
Sbjct: 143 HLHA-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 240 ----QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
Y +SDIWS+G++ +E+A G P+
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL---------------------------- 233
Query: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
D P A+F I PPP+L + ++ F +F++ CLIK
Sbjct: 234 --------------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYL 275
Query: 356 ERADLKMLTNHTFIKRSEVE 375
R + L FI+ E
Sbjct: 276 SRPPTEQLLKFPFIRDQPTE 295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 118 bits (295), Expect = 1e-26
Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 65/320 (20%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 130
FE + +G G G V K +H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 131 VGFYGAFY------SDGEISICMEHMDGGSLDQVLKEAK--RIPEEILGKVSIAVLRGLA 182
+YGAF +D ++ + ME GS+ ++K K + E+ + + +LRGLA
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL- 239
+L H+++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +MAPE +
Sbjct: 143 HLHA-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 240 ----QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
Y +SDIWS+G++ +E+A G P+
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL---------------------------- 233
Query: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
D P A+F I PPP+L + ++ F +F++ CLIK
Sbjct: 234 --------------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYL 275
Query: 356 ERADLKMLTNHTFIKRSEVE 375
R + L FI+ E
Sbjct: 276 SRPPTEQLLKFPFIRDQPTE 295
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 118 bits (295), Expect = 1e-26
Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 65/320 (20%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 130
FE + +G G G V K +H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 131 VGFYGAFY------SDGEISICMEHMDGGSLDQVLKEAK--RIPEEILGKVSIAVLRGLA 182
+YGAF +D ++ + ME GS+ ++K K + E+ + + +LRGLA
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL- 239
+L H+++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +MAPE +
Sbjct: 143 HLHA-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 240 ----QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
Y +SDIWS+G++ +E+A G P+
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL---------------------------- 233
Query: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
D P A+F I PPP+L + ++ F +F++ CLIK
Sbjct: 234 --------------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYL 275
Query: 356 ERADLKMLTNHTFIKRSEVE 375
R + L FI+ E
Sbjct: 276 SRPPTEQLLKFPFIRDQPTE 295
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 118 bits (295), Expect = 1e-26
Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 65/320 (20%)
Query: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 130
FE + +G G G V K +H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNI 82
Query: 131 VGFYGAFY------SDGEISICMEHMDGGSLDQVLKEAK--RIPEEILGKVSIAVLRGLA 182
+YGAF +D ++ + ME GS+ ++K K + E+ + + +LRGLA
Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142
Query: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERL- 239
+L H+++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +MAPE +
Sbjct: 143 HLHA-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 240 ----QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 295
Y +SDIWS+G++ +E+A G P+
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPL---------------------------- 233
Query: 296 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 355
D P A+F I PPP+L + ++ F +F++ CLIK
Sbjct: 234 --------------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYL 275
Query: 356 ERADLKMLTNHTFIKRSEVE 375
R + L FI+ E
Sbjct: 276 SRPPTEQLLKFPFIRDQPTE 295
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 117 bits (294), Expect = 1e-26
Identities = 100/368 (27%), Positives = 166/368 (45%), Gaps = 60/368 (16%)
Query: 6 KPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVG 65
K + I+P A +GA+++ +D QKK ++ DE+ ++L ++ +G
Sbjct: 191 KSIYTRSVIDPVPAPVGDSHVDGAAKS--LDKQKKKTKMT-DEEIMEKLRTIVS----IG 243
Query: 66 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC 125
+ K + R ++G G G V G +A K I+L+ +P + II E+ V+ E
Sbjct: 244 DPKKK-YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPK-KELIINEILVMKEL 301
Query: 126 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLR 185
+P IV F ++ E+ + ME++ GGSL V+ E + E + V L+ L +L
Sbjct: 302 KNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETC-MDEAQIAAVCRECLQALEFLH 360
Query: 186 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMAPERLQGTH 243
+Q++HRD+K N+L+ G +KL DFG Q+ S ++ VGT +MAPE +
Sbjct: 361 A-NQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 419
Query: 244 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGR 303
Y + DIWS+G+ +E+ EGEP ++ P
Sbjct: 420 YGPKVDIWSLGIMAIEMV--------------------------EGEPPYLNENP----- 448
Query: 304 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPN-GVFTPDFQEFVNKCLIKNPAERADLKM 362
L I P+L N +P F++F+N+CL + +R K
Sbjct: 449 ---------------LRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKE 493
Query: 363 LTNHTFIK 370
L H F+K
Sbjct: 494 LLQHPFLK 501
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 117 bits (294), Expect = 1e-26
Identities = 87/306 (28%), Positives = 140/306 (45%), Gaps = 54/306 (17%)
Query: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 129
D FE + +GAG G V K + + + A K++ L+ I + + +E+ +L EC P
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDI-SSLQQEITILRECRHPN 72
Query: 130 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ 189
+V + G++ + + ICME GGSL ++ + E + V L+GL +L + +
Sbjct: 73 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGK 132
Query: 190 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAP-----ERLQGT 242
I HRD+K +N+L+ +G++KL DFGVSG+L S+A SF+GT +MAP ER G
Sbjct: 133 I-HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGG- 190
Query: 243 HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPG 302
Y+ D+W++G++ +EL E +P P
Sbjct: 191 -YNELCDVWALGITAIELG--------------------------ELQPPLFHLHP---- 219
Query: 303 RPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKM 362
M L+ +PP +T +F F+ L KNP +R +
Sbjct: 220 -------------MRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEK 266
Query: 363 LTNHTF 368
L H F
Sbjct: 267 LLQHPF 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,380,945
Number of Sequences: 37866
Number of extensions: 917181
Number of successful extensions: 5891
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 646
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 3651
Number of HSP's gapped (non-prelim): 1130
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.