Search of human proteins with 6005814

Search of human proteins with 6005814

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6005814 serine/threonine kinase 38 [Homo sapiens]
         (465 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6005814 serine/threonine kinase 38 [Homo sapiens]                  948   0.0  
gi|24307971 serine/threonine kinase 38 like [Homo sapiens]            824   0.0  
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]   383   e-106
gi|4758666 LATS homolog 1 [Homo sapiens]                              377   e-104
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]         308   5e-84
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...   308   5e-84
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...   308   5e-84
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...   296   3e-80
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   283   2e-76
gi|41872583 Rho-associated, coiled-coil containing protein kinas...   275   6e-74
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s...   274   1e-73
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s...   274   1e-73
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s...   274   1e-73
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa...   274   1e-73
gi|32698688 citron [Homo sapiens]                                     248   8e-66
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   225   8e-59
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   221   1e-57
gi|150170729 microtubule associated serine/threonine kinase 3 [H...   219   3e-57
gi|148727255 microtubule associated serine/threonine kinase fami...   219   3e-57
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   219   4e-57
gi|112363080 microtubule associated serine/threonine kinase 2 [H...   219   5e-57
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   219   5e-57
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   219   5e-57
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho...   218   7e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   211   1e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   209   3e-54
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   209   6e-54
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   207   1e-53
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   207   1e-53
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...   207   2e-53

>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
          Length = 465

 Score =  948 bits (2451), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60
           MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE
Sbjct: 1   MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60

Query: 61  EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL 120
           EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL
Sbjct: 61  EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL 120

Query: 121 RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK 180
           RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK
Sbjct: 121 RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK 180

Query: 181 KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA 240
           KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA
Sbjct: 181 KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA 240

Query: 241 HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN 300
           HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN
Sbjct: 241 HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN 300

Query: 301 KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 360
           KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF
Sbjct: 301 KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 360

Query: 361 CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK 420
           CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK
Sbjct: 361 CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK 420

Query: 421 PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
           PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
Sbjct: 421 PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465


>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
          Length = 464

 Score =  824 bits (2128), Expect = 0.0
 Identities = 405/466 (86%), Positives = 430/466 (92%), Gaps = 4/466 (0%)

Query: 1   MAMT-GSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKD 59
           MAMT G+T    MSNHT+ERVT+ K+TLENFYSNLI QHEERE RQKKLE  MEEEGL D
Sbjct: 1   MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD 60

Query: 60  EEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKI 119
           EEK+LRRS HARKETEFLRLKRTRLGL+DFESLKVIGRGAFGEVRLVQKKDTGH+YAMKI
Sbjct: 61  EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI 120

Query: 120 LRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLM 179
           LRK+DMLEKEQV HIRAERDILVEAD  WVVKMFYSFQDK NLYLIMEFLPGGDMMTLLM
Sbjct: 121 LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM 180

Query: 180 KKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKK 239
           KKDTLTEEETQFYI+ETVLAID+IHQLGFIHRDIKPDNLLLD+KGHVKLSDFGLCTGLKK
Sbjct: 181 KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK 240

Query: 240 AHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGY 299
           AHRTEFYRNL H+ PSDF+FQNMNSKRKAETWK+NRRQLA+STVGTPDYIAPEVFMQTGY
Sbjct: 241 AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY 300

Query: 300 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILR 359
           NKLCDWWSLGVIMYEMLIGYPPFCSETPQETY+KVMNWKETL FPPEVPISEKAKDLILR
Sbjct: 301 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR 360

Query: 360 FCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDIL 419
           FC + E+RIG  GVEEIK + FFEGVDWEHIRERPAAI IEIKSIDDTSNFD+FPESDIL
Sbjct: 361 FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL 420

Query: 420 KPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
           +P     N  E DYK+KDWVF+NYTYKRFEGLT RG+IP+YMKA K
Sbjct: 421 QP---VPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGK 463


>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
          Length = 1088

 Score =  383 bits (983), Expect = e-106
 Identities = 196/443 (44%), Positives = 287/443 (64%), Gaps = 18/443 (4%)

Query: 24   KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
            K  +E    N+I  ++++  R+ +LE+ M + GL + E+   R    +KE+ + RLKR +
Sbjct: 603  KFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662

Query: 84   LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
            +    F  +K +G GAFGEV L  K DT  +YAMK LRK D+L + QV H++AERDIL E
Sbjct: 663  MDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 722

Query: 144  ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
            AD+ WVVK++YSFQDK +LY +M+++PGGDMM+LL++ +   E   +FYIAE  LAI+S+
Sbjct: 723  ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV 782

Query: 204  HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNH-----SLPSDFT 258
            H++GFIHRDIKPDN+L+D  GH+KL+DFGLCTG +  H +++Y+  +H       PSD  
Sbjct: 783  HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLW 842

Query: 259  FQNMNSK-------RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
                N +        +    K+++R LA S VGTP+YIAPEV ++ GY +LCDWWS+GVI
Sbjct: 843  DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI 902

Query: 312  MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
            ++EML+G PPF + TP ET  KV+NW+ TL  P +V +S +A+DLI + CC  +HR+G  
Sbjct: 903  LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN 962

Query: 372  GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFD----EFPESDILK-PTVAT 425
            G +++K++ FF  +D+   IR++PA     I    DTSNFD    E P +D  +  T A 
Sbjct: 963  GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAW 1022

Query: 426  SNHPETDYKNKDWVFINYTYKRF 448
                  + K+ +  F  +T++RF
Sbjct: 1023 DTLTSPNNKHPEHAFYEFTFRRF 1045


>gi|4758666 LATS homolog 1 [Homo sapiens]
          Length = 1130

 Score =  377 bits (967), Expect = e-104
 Identities = 190/444 (42%), Positives = 284/444 (63%), Gaps = 19/444 (4%)

Query: 24   KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
            K  +E    N++  H++R  R+K+LE  M   GL  + +   R    +KE+ ++RLKR +
Sbjct: 640  KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAK 699

Query: 84   LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
            +    F  +K +G GAFGEV L +K DT  +YA K LRK D+L + QV H++AERDIL E
Sbjct: 700  MDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE 759

Query: 144  ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
            AD+ WVV+++YSFQDK NLY +M+++PGGDMM+LL++     E   +FYIAE   A++S+
Sbjct: 760  ADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESV 819

Query: 204  HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN-- 261
            H++GFIHRDIKPDN+L+D  GH+KL+DFGLCTG +  H +++Y++ +H       F N  
Sbjct: 820  HKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEW 879

Query: 262  --MNSKRKAETWK--------RNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
               +S R  +  K        +++R LA S VGTP+YIAPEV ++TGY +LCDWWS+GVI
Sbjct: 880  GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI 939

Query: 312  MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
            ++EML+G PPF ++TP ET  KV+NW+ +L  PP+  +S +A DLI++ C   E R+G  
Sbjct: 940  LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN 999

Query: 372  GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
            G +EIK++ FF+ +D+   +R++ A+   +I    DTSNFD      +        N  +
Sbjct: 1000 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059

Query: 431  T------DYKNKDWVFINYTYKRF 448
            T      + K+ +  F  +T++RF
Sbjct: 1060 TLNGWYKNGKHPEHAFYEFTFRRF 1083


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score =  308 bits (790), Expect = 5e-84
 Identities = 175/412 (42%), Positives = 242/412 (58%), Gaps = 48/412 (11%)

Query: 64  LRRSAHARKETEFLR-----LKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMK 118
           LRR  +  +  E+ +     +K  +L  EDFE +KVIGRGAFGEV +V+ K+T  +YAMK
Sbjct: 46  LRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMK 105

Query: 119 ILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL 178
           IL K +ML++ +    R ERD+LV  D  W+  + Y+FQD+ +LYL+M++  GGD++TLL
Sbjct: 106 ILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL 165

Query: 179 MK-KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGL 237
            K +D L E+  +FYI E VLAIDSIHQL ++HRDIKPDN+LLD  GH++L+DFG C   
Sbjct: 166 SKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCL-- 223

Query: 238 KKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--M 295
                          +  D T Q+                     VGTPDYI+PE+   M
Sbjct: 224 --------------KMNDDGTVQSS------------------VAVGTPDYISPEILQAM 251

Query: 296 QTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISE 351
           + G   Y   CDWWSLGV MYEML G  PF +E+  ETY K+MN +E   FP  V  +SE
Sbjct: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311

Query: 352 KAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
           +AKDLI R  C  E R+G  G+E+ K ++FFEG++WE+IR   A    ++ S  DTSNFD
Sbjct: 312 EAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFD 371

Query: 412 EFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKA 463
              + D+L+ T        T +      FI +T+      + RG++ S M++
Sbjct: 372 --VDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQS 421


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
           sapiens]
          Length = 1719

 Score =  308 bits (790), Expect = 5e-84
 Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)

Query: 78  RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
           ++K+ RL  EDFE LKVIGRGAFGEV +V+ K+   V+AMKIL K +ML++ +    R E
Sbjct: 66  KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125

Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
           RD+LV  D+ W+  + Y+FQD  NLYL+M++  GGD++TLL K +D L E+  +FY+AE 
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185

Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
           V+AIDS+HQL ++HRDIKPDN+L+D  GH++L+DFG C                  L  D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229

Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
            T Q+                     VGTPDYI+PE+   M+ G   Y   CDWWSLGV 
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271

Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370
           MYEML G  PF +E+  ETY K+MN KE   FP +V  +SE AKDLI R  C  EHR+G 
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331

Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
            G+E+ K + FF G+DW++IR   A    E+ S  DTSNFD   + D LK +        
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389

Query: 431 TDYKNKDWVFINYTY 445
           T +      F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
           sapiens]
          Length = 1638

 Score =  308 bits (790), Expect = 5e-84
 Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)

Query: 78  RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
           ++K+ RL  EDFE LKVIGRGAFGEV +V+ K+   V+AMKIL K +ML++ +    R E
Sbjct: 66  KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125

Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
           RD+LV  D+ W+  + Y+FQD  NLYL+M++  GGD++TLL K +D L E+  +FY+AE 
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185

Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
           V+AIDS+HQL ++HRDIKPDN+L+D  GH++L+DFG C                  L  D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229

Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
            T Q+                     VGTPDYI+PE+   M+ G   Y   CDWWSLGV 
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271

Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370
           MYEML G  PF +E+  ETY K+MN KE   FP +V  +SE AKDLI R  C  EHR+G 
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331

Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
            G+E+ K + FF G+DW++IR   A    E+ S  DTSNFD   + D LK +        
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389

Query: 431 TDYKNKDWVFINYTY 445
           T +      F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score =  296 bits (757), Expect = 3e-80
 Identities = 163/382 (42%), Positives = 226/382 (59%), Gaps = 57/382 (14%)

Query: 78  RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
           ++K  RL  +DFE LKVIGRGAFGEV +V+++DTG ++AMK+L K +ML++ +    R E
Sbjct: 60  KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119

Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
           RD+LV+ DS WV  + Y+FQD+  LYL+M++  GGD++TLL + +D L  E  QFY+AE 
Sbjct: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179

Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
           VLAI S+HQLG++HRD+KPDN+LLD  GH++L+DFG C  L          N N  + S 
Sbjct: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRL----------NTNGMVDSS 229

Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
                                     VGTPDYI+PE+   M+ G   Y   CDWWSLGV 
Sbjct: 230 V------------------------AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVC 265

Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVP-ISEKAKDLILRFCCEWEHRIGA 370
            YE+L G  PF +E+  ETY K+MN ++ L FPP+VP +   A+DLI +  C  E R+G 
Sbjct: 266 AYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGR 325

Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
            G+++ +++ FFEGVDWE +    A    E++   DTSNFD   +         T NHP 
Sbjct: 326 GGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDD---------TLNHPG 376

Query: 431 T-------DYKNKDWVFINYTY 445
           T        +      F+ +TY
Sbjct: 377 TLPPPSHGAFSGHHLPFVGFTY 398


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score =  283 bits (725), Expect = 2e-76
 Identities = 150/344 (43%), Positives = 211/344 (61%), Gaps = 41/344 (11%)

Query: 78  RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
           +++  R+  ED+E +KVIGRGAFGEV+LV+ K T  VYAMK+L K +M+++        E
Sbjct: 65  KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124

Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 197
           RDI+  A+S WVV++FY+FQD   LY++ME++PGGD++ L+   D + E+  +FY AE V
Sbjct: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVV 183

Query: 198 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 257
           LA+D+IH +GFIHRD+KPDN+LLD  GH+KL+DFG C  + K                  
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVR------------- 230

Query: 258 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMY 313
                                  + VGTPDYI+PEV    G    Y + CDWWS+GV +Y
Sbjct: 231 ---------------------CDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269

Query: 314 EMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGV 373
           EML+G  PF +++   TY K+MN K +LTFP +  IS++AK+LI  F  + E R+G  GV
Sbjct: 270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGV 329

Query: 374 EEIKSNSFFEGVD--WEHIRERPAAISIEIKSIDDTSNFDEFPE 415
           EEIK + FF+     WE +R+  A +  ++ S  DTSNFD+  E
Sbjct: 330 EEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE 373


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score =  275 bits (703), Expect = 6e-74
 Identities = 153/383 (39%), Positives = 223/383 (58%), Gaps = 45/383 (11%)

Query: 71  RKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQ 130
           R E    +++  ++  ED++ +KVIGRGAFGEV+LV+ K +  VYAMK+L K +M+++  
Sbjct: 74  RYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSD 133

Query: 131 VGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQ 190
                 ERDI+  A+S WVV++FY+FQD   LY++ME++PGGD++ L+   D + E+  +
Sbjct: 134 SAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAK 192

Query: 191 FYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLN 250
           FY AE VLA+D+IH +G IHRD+KPDN+LLD  GH+KL+DFG C  + +           
Sbjct: 193 FYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVH------ 246

Query: 251 HSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG----YNKLCDWW 306
                                         + VGTPDYI+PEV    G    Y + CDWW
Sbjct: 247 ----------------------------CDTAVGTPDYISPEVLKSQGGDGFYGRECDWW 278

Query: 307 SLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH 366
           S+GV +YEML+G  PF +++   TY K+M+ K +L FP +  IS+ AK+LI  F  + E 
Sbjct: 279 SVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV 338

Query: 367 RIGAPGVEEIKSNSFFEGVD--WEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVA 424
           R+G  GVEEI+ + FF+     W++IRE  A +  E+ S  D+SNFD+  +    K  V 
Sbjct: 339 RLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDD---KGDVE 395

Query: 425 TSNHPETDYKNKDWVFINYTYKR 447
           T   P+  +      FI +TY R
Sbjct: 396 TFPIPKA-FVGNQLPFIGFTYYR 417


>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
           sapiens]
          Length = 639

 Score =  274 bits (701), Expect = 1e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 69  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128

Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188

Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 232

Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 233 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274

Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 275 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 334

Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 335 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 378


>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
           sapiens]
          Length = 625

 Score =  274 bits (701), Expect = 1e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 59  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118

Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178

Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222

Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264

Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324

Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368


>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
           sapiens]
          Length = 624

 Score =  274 bits (701), Expect = 1e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 59  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118

Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178

Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222

Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264

Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324

Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368


>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
           sapiens]
          Length = 629

 Score =  274 bits (701), Expect = 1e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 59  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118

Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178

Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222

Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264

Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324

Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  248 bits (633), Expect = 8e-66
 Identities = 139/383 (36%), Positives = 211/383 (55%), Gaps = 46/383 (12%)

Query: 79  LKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAER 138
           L+  +   +DFE   ++G G F EV++V++K TG +YAMK+++K  +L +EQV     ER
Sbjct: 87  LQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEER 146

Query: 139 DILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAETV 197
           +IL  + S W+ ++ Y+FQDK +LYL+ME+ PGGD+++LL + +D L E   QFY+AE +
Sbjct: 147 NILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELI 206

Query: 198 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 257
           LA+ S+H +G++HRDIKP+N+L+D  GH+KL DFG       A +    + +N  LP   
Sbjct: 207 LAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG------SAAKMNSNKMVNAKLP--- 257

Query: 258 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM------QTGYNKLCDWWSLGVI 311
                                    +GTPDY+APEV        +  Y   CDWWS+GVI
Sbjct: 258 -------------------------IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVI 292

Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
            YEM+ G  PF   T   T+  +MN++  L FP +  +S    DLI    C  + R+   
Sbjct: 293 AYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFE 352

Query: 372 GVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPET 431
           G   +  + FF  +DW +IR  P      +KS DDTSNFDE PE +    +      P +
Sbjct: 353 G---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDE-PEKNSWVSSSPCQLSP-S 407

Query: 432 DYKNKDWVFINYTYKRFEGLTAR 454
            +  ++  F+ ++Y +  G+  R
Sbjct: 408 GFSGEELPFVGFSYSKALGILGR 430


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  225 bits (573), Expect = 8e-59
 Identities = 141/432 (32%), Positives = 220/432 (50%), Gaps = 63/432 (14%)

Query: 1   MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60
           MA     PC+  +       T     LE F S L  +H +     +K    +E + L   
Sbjct: 1   MAAYREPPCNQYTG-----TTTALQKLEGFASRLFHRHSKGTAHDQKT--ALENDSLHFS 53

Query: 61  EK-----RLRRSAHARKETEFLRL----KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDT 111
           E      R  +   A+ + +FL+      +   GLEDFE  K +G G+FG V LV+ K T
Sbjct: 54  EHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKAT 113

Query: 112 GHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPG 171
              YAMKIL K  +++ +Q+ H   E+ IL   +  ++V++ Y+F+D  NLY++ME++PG
Sbjct: 114 EQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPG 173

Query: 172 GDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDF 231
           G+M + L +    +E   +FY A+ VL  + +H L  I+RD+KP+NLL+D +G+++++DF
Sbjct: 174 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDF 233

Query: 232 GLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAP 291
           G                                + K  TW         +  GTP+Y+AP
Sbjct: 234 GFA-----------------------------KRVKGRTW---------TLCGTPEYLAP 255

Query: 292 EVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISE 351
           E+ +  GYNK  DWW+LGV++YEM  GYPPF ++ P + Y+K+++ K  + FP     S 
Sbjct: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSS 311

Query: 352 KAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFEGVDWEHIRER--PAAISIEIKSIDD 406
             KDL+      +   R G    GV +IK++ +F   DW  I +R   A    + +   D
Sbjct: 312 DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGD 371

Query: 407 TSNFDEFPESDI 418
           TSNFD++ E DI
Sbjct: 372 TSNFDDYEEEDI 383


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  221 bits (563), Expect = 1e-57
 Identities = 130/328 (39%), Positives = 192/328 (58%), Gaps = 44/328 (13%)

Query: 89  FESLKVIGRGAFGEVRLVQKK---DTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
           FE LKV+G+G+FG+V LV+KK   D G +YAMK+L+KA +  +++V   + ERDILVE +
Sbjct: 73  FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 131

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
             ++VK+ Y+FQ +  LYLI++FL GGD+ T L K+   TEE+ +FY+AE  LA+D +HQ
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191

Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
           LG ++RD+KP+N+LLD  GH+KL+DFGL                              SK
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGL------------------------------SK 221

Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
              +  K+     A+S  GT +Y+APEV  + G+++  DWWS GV+M+EML G  PF  +
Sbjct: 222 ESVDQEKK-----AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK 276

Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGV 385
              ET   ++  K  +   P+   +E    L + F     +R+G+ GVEEIK + FF  +
Sbjct: 277 DRNETMNMILKAKLGM---PQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANI 333

Query: 386 DWEHIRERPAAISIEIKS--IDDTSNFD 411
           DW+ + +R      +  S   DDT  FD
Sbjct: 334 DWDKLYKREVQPPFKPASGKPDDTFCFD 361



 Score =  101 bits (251), Expect = 2e-21
 Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 50/279 (17%)

Query: 87  EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
           E +E  + IG G++   +      T   +A+KI+ K+     E++       +IL+    
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI-------EILMRYGQ 476

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
              ++ +   F D   +YL+ + + GG+++  ++K+   +E E    +      +D +H 
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 536

Query: 206 LGFIHRDIKPDNLLL----DSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
            G +HRD+KP N+L      S   +++ DFG    L                        
Sbjct: 537 QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL------------------------ 572

Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
                      R    L  +   T +++APEV MQ GY+  CD WSLGV+ Y ML GY P
Sbjct: 573 -----------RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTP 621

Query: 322 FC---SETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
           F    ++TP+E   ++ N K +L+      IS+ AKDL+
Sbjct: 622 FANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL 660


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
           sapiens]
          Length = 1309

 Score =  219 bits (559), Expect = 3e-57
 Identities = 127/365 (34%), Positives = 199/365 (54%), Gaps = 25/365 (6%)

Query: 48  LEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQ 107
           LE+++    L++E+     S  +R      R K       DFE++K+I  GA+G V LV+
Sbjct: 329 LEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCE---SDFETIKLISNGAYGAVYLVR 385

Query: 108 KKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIME 167
            +DT   +A+K + K +++ + Q+  +  ERDIL  A++ +VV MF SF+ + +L ++ME
Sbjct: 386 HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVME 445

Query: 168 FLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVK 227
           ++ GGD  TLL     L  +  + Y AETVLA++ +H  G +HRD+KPDNLL+ S GH+K
Sbjct: 446 YVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIK 505

Query: 228 LSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPD 287
           L+DFGL      +  T  Y                    +    K  R  +     GTP+
Sbjct: 506 LTDFGLSKIGLMSMATNLY--------------------EGHIEKDAREFIDKQVCGTPE 545

Query: 288 YIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV 347
           YIAPEV  + GY K  DWW++GV++YE L+G  PF  +TP+E + +V++  E +    + 
Sbjct: 546 YIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS-DEIMWPEGDE 604

Query: 348 PISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDD 406
            +   A+DLI R   +    R+G  G  E+K + FF  +DW  +    A    ++++ DD
Sbjct: 605 ALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDD 664

Query: 407 TSNFD 411
           TS FD
Sbjct: 665 TSYFD 669


>gi|148727255 microtubule associated serine/threonine kinase family
           member 4 isoform a [Homo sapiens]
          Length = 2434

 Score =  219 bits (559), Expect = 3e-57
 Identities = 121/328 (36%), Positives = 184/328 (56%), Gaps = 28/328 (8%)

Query: 88  DFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSL 147
           DFE++K+I  GA+G V  V+ K++   +AMK + K +++ + Q+     ERDIL  A++ 
Sbjct: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439

Query: 148 WVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG 207
           +VV M+ SF+ + +L ++ME++ GGD  TL+     L  +  + Y AETVLA++ +H  G
Sbjct: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499

Query: 208 FIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
            +HRD+KPDNLL+ S GH+KL+DFGL      +  T  Y                    +
Sbjct: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLY--------------------E 539

Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 327
               K  R  L     GTP+YIAPEV ++ GY K  DWW++G+I+YE L+G  PF  +TP
Sbjct: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599

Query: 328 QETYKKV----MNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFE 383
           +E + +V    +NW E    PP  P ++    L+LR       R+G  G  E+K + FF 
Sbjct: 600 EELFGQVISDEINWPEKDEAPP--PDAQDLITLLLR--QNPLERLGTGGAYEVKQHRFFR 655

Query: 384 GVDWEHIRERPAAISIEIKSIDDTSNFD 411
            +DW  +  + A    +++S DDTS FD
Sbjct: 656 SLDWNSLLRQKAEFIPQLESEDDTSYFD 683


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  219 bits (558), Expect = 4e-57
 Identities = 131/384 (34%), Positives = 207/384 (53%), Gaps = 64/384 (16%)

Query: 40  EREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGA 99
           E+E  ++ L K  +E+ LK  E   + +AH                L+ FE +K +G G+
Sbjct: 12  EQESVKEFLAKA-KEDFLKKWESPAQNTAH----------------LDQFERIKTLGTGS 54

Query: 100 FGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDK 159
           FG V LV+ K+TG+ YAMKIL K  +++ +Q+ H   E+ IL   +  ++VK+ +SF+D 
Sbjct: 55  FGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDN 114

Query: 160 LNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLL 219
            NLY++ME++PGG+M + L +    +E   +FY A+ VL  + +H L  I+RD+KP+NLL
Sbjct: 115 SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL 174

Query: 220 LDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA 279
           +D +G+++++DFG                                + K  TW        
Sbjct: 175 IDQQGYIQVTDFGFA-----------------------------KRVKGRTW-------- 197

Query: 280 FSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKE 339
            +  GTP+Y+APE+ +  GYNK  DWW+LGV++YEM  GYPPF ++ P + Y+K+++ K 
Sbjct: 198 -TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK- 255

Query: 340 TLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFEGVDWEHIRER--P 394
            + FP     S   KDL+      +   R G    GV +IK++ +F   DW  I +R   
Sbjct: 256 -VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312

Query: 395 AAISIEIKSIDDTSNFDEFPESDI 418
           A    + K   DTSNFD++ E +I
Sbjct: 313 APFIPKFKGPGDTSNFDDYEEEEI 336


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
           sapiens]
          Length = 1798

 Score =  219 bits (557), Expect = 5e-57
 Identities = 122/327 (37%), Positives = 185/327 (56%), Gaps = 24/327 (7%)

Query: 87  EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 146
           EDFE++K+I  GA+G V LV+ K T   +AMK + K +++ + Q+     ERDIL  A++
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569

Query: 147 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206
            +VV MF SF  K +L ++ME++ GGD  TLL     L  +  + Y AETVLA++ +H  
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629

Query: 207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 266
           G +HRD+KPDNLL+ S GH+KL+DFGL      +  T  Y                    
Sbjct: 630 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLY-------------------- 669

Query: 267 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 326
           +    K  R  L     GTP+YIAPEV ++ GY K  DWW++G+I+YE L+G  PF  +T
Sbjct: 670 EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDT 729

Query: 327 PQETYKKVMNWKETLTFPP-EVPISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEG 384
           P+E + +V++  + + +P  +  +   A+DL  +   +    R+G     E+K + FF G
Sbjct: 730 PEELFGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG 787

Query: 385 VDWEHIRERPAAISIEIKSIDDTSNFD 411
           +DW  +  + A    +++S DDTS FD
Sbjct: 788 LDWTGLLRQKAEFIPQLESEDDTSYFD 814


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  219 bits (557), Expect = 5e-57
 Identities = 121/338 (35%), Positives = 190/338 (56%), Gaps = 47/338 (13%)

Query: 86  LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
           L+ FE +K +G G+FG V LV+ K+TG+ YAMKIL K  +++ +Q+ H   E+ IL   +
Sbjct: 33  LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
             ++VK+ +SF+D  NLY++ME++PGG+M + L +    +E   +FY A+ VL  + +H 
Sbjct: 93  FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152

Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
           L  I+RD+KP+NLL+D +G+++++DFG                                +
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFA-----------------------------KR 183

Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
            K  TW         +  GTP+Y+APE+ +  GYNK  DWW+LGV++YEM  GYPPF ++
Sbjct: 184 VKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 234

Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFF 382
            P + Y+K+++ K  + FP     S   KDL+      +   R G    GV +IK++ +F
Sbjct: 235 QPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 290

Query: 383 EGVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
              DW  I +R   A    + K   DTSNFD++ E +I
Sbjct: 291 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 328


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  219 bits (557), Expect = 5e-57
 Identities = 125/358 (34%), Positives = 196/358 (54%), Gaps = 51/358 (14%)

Query: 70  ARKETEFLRL----KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADM 125
           A+ + +FL+      +   GLEDFE  K +G G+FG V LV+ K T   YAMKIL K  +
Sbjct: 21  AKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKV 80

Query: 126 LEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLT 185
           ++ +Q+ H   E+ IL   +  ++V++ Y+F+D  NLY++ME++PGG+M + L +    +
Sbjct: 81  VKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140

Query: 186 EEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEF 245
           E   +FY A+ VL  + +H L  I+RD+KP+NLL+D +G+++++DFG             
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA----------- 189

Query: 246 YRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDW 305
                              + K  TW         +  GTP+Y+APE+ +  GYNK  DW
Sbjct: 190 ------------------KRVKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDW 222

Query: 306 WSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEW 364
           W+LGV++YEM  GYPPF ++ P + Y+K+++ K  + FP     S   KDL+      + 
Sbjct: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDL 278

Query: 365 EHRIG--APGVEEIKSNSFFEGVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
             R G    GV +IK++ +F   DW  I +R   A    + +   DTSNFD++ E DI
Sbjct: 279 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 336


>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
           sapiens]
          Length = 1570

 Score =  218 bits (556), Expect = 7e-57
 Identities = 121/329 (36%), Positives = 184/329 (55%), Gaps = 24/329 (7%)

Query: 85  GLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA 144
           G  DF+++K+I  GA+G V LV+ +DT   +AMK + K +++ + Q+     ERDIL  A
Sbjct: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429

Query: 145 DSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIH 204
           ++ +VV MF SF+ + +L ++ME++ GGD  TLL     L  E  + Y AETVLA++ +H
Sbjct: 430 ENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLH 489

Query: 205 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 264
             G +HRD+KPDNLL+ S GH+KL+DFGL      +  T  Y                  
Sbjct: 490 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLY------------------ 531

Query: 265 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 324
             +    K  R  L     GTP+YIAPEV ++ GY K  DWW++G+I+YE L+G  PF  
Sbjct: 532 --EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG 589

Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFF 382
           +TP+E + +V++  + + +P           L++    +     R+GA G  E+K +SFF
Sbjct: 590 DTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF 647

Query: 383 EGVDWEHIRERPAAISIEIKSIDDTSNFD 411
             +DW  +  + A     ++S DDTS FD
Sbjct: 648 RDLDWTGLLRQKAEFIPHLESEDDTSYFD 676


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  211 bits (537), Expect = 1e-54
 Identities = 131/360 (36%), Positives = 200/360 (55%), Gaps = 46/360 (12%)

Query: 39  EEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRG 98
           +  E  Q+ +++ M EE +  + + +  S      T  ++    +     FE LKV+G+G
Sbjct: 20  DSAENGQQIMDEPMGEEEINPQTEEV--SIKEIAITHHVKEGHEKADPSQFELLKVLGQG 77

Query: 99  AFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYS 155
           +FG+V LV+K    D   +YAMK+L+KA +  +++V   + ERDILVE +  ++VK+ Y+
Sbjct: 78  SFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYA 136

Query: 156 FQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKP 215
           FQ +  LYLI++FL GGD+ T L K+   TEE+ +FY+AE  LA+D +H LG I+RD+KP
Sbjct: 137 FQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKP 196

Query: 216 DNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNR 275
           +N+LLD +GH+KL+DFGL                              SK   +  K+  
Sbjct: 197 ENILLDEEGHIKLTDFGL------------------------------SKESIDHEKK-- 224

Query: 276 RQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVM 335
              A+S  GT +Y+APEV  + G+ +  DWWS GV+M+EML G  PF  +  +ET   ++
Sbjct: 225 ---AYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL 281

Query: 336 NWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFEGVDWEHIRER 393
             K  +   P+    E    L + F     +R+GA   GVEEIK +SFF  +DW  +  R
Sbjct: 282 KAKLGM---PQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRR 338



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 68/279 (24%), Positives = 129/279 (46%), Gaps = 50/279 (17%)

Query: 87  EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
           + +E  + IG G++   +    K T   +A+KI+ K+     E++       +IL+    
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI-------EILLRYGQ 472

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
              ++ +   + D   +Y++ E + GG+++  ++++   +E E    +      ++ +H 
Sbjct: 473 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 532

Query: 206 LGFIHRDIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
            G +HRD+KP N+L +D  G+   +++ DFG    L                        
Sbjct: 533 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL------------------------ 568

Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
                      R    L  +   T +++APEV  + GY+  CD WSLGV++Y ML GY P
Sbjct: 569 -----------RAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTP 617

Query: 322 FCS---ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
           F +   +TP+E   ++ + K +L+      +S+ AKDL+
Sbjct: 618 FANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLV 656


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  209 bits (533), Expect = 3e-54
 Identities = 145/411 (35%), Positives = 218/411 (53%), Gaps = 63/411 (15%)

Query: 20  VTMTKVTLENFYSNLIAQHEEREMRQKKLE-KVMEEEGLKDEEKRLRRSAHARKETEFLR 78
           ++M K  +  F+S  +     R+ R K      +EEEG+    K +  S H ++  E   
Sbjct: 3   LSMKKFAVRRFFSVYL----RRKSRSKSSSLSRLEEEGVV---KEIDISHHVKEGFE--- 52

Query: 79  LKRTRLGLEDFESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIR 135
               +     FE LKV+G+G++G+V LV+K    D G +YAMK+L+KA +  +++V   +
Sbjct: 53  ----KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRV-RSK 107

Query: 136 AERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAE 195
            ERDIL E +  ++VK+ Y+FQ +  LYLI++FL GGD+ T L K+   TEE+ +FY+AE
Sbjct: 108 MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167

Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
             LA+D +H LG I+RD+KP+N+LLD +GH+K++DFGL                      
Sbjct: 168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---------------------- 205

Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 315
                   SK   +  KR     A+S  GT +Y+APEV  + G+ +  DWWS GV+M+EM
Sbjct: 206 --------SKEAIDHDKR-----AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEM 252

Query: 316 LIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGV 373
           L G  PF  +  +ET   ++  K  +   P+    E    L   F     +R+GA   GV
Sbjct: 253 LTGSLPFQGKDRKETMALILKAKLGM---PQFLSGEAQSLLRALFKRNPCNRLGAGIDGV 309

Query: 374 EEIKSNSFFEGVDWEHI--RERPAAISIEIKSIDDTSNFDEFPESDILKPT 422
           EEIK + FF  +DW  +  +E        +   +DT +FD  PE     PT
Sbjct: 310 EEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD--PEFTARTPT 358



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 69/279 (24%), Positives = 128/279 (45%), Gaps = 50/279 (17%)

Query: 87  EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
           + +E  + IG G++   +    K T   YA+KI+ K+     E++       +IL+    
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI-------EILLRYGQ 465

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
              ++ +   + D   +YL+ME + GG+++  ++++   +E E    +      +D +H 
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525

Query: 206 LGFIHRDIKPDNLLL-DSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
            G +HRD+KP N+L  D  G    +++ DFG    L+  +                    
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG------------------- 566

Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
                           L  +   T +++APEV  + GY+  CD WSLG+++Y ML G+ P
Sbjct: 567 ----------------LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 610

Query: 322 FCS---ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
           F +   +TP+E   ++ + K  L+      IS+ AKD++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 649


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  209 bits (531), Expect = 6e-54
 Identities = 117/337 (34%), Positives = 187/337 (55%), Gaps = 47/337 (13%)

Query: 87  EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 146
           + FE L+ +G G+FG V LV+ ++TG  YAMKIL K  +++ +QV HI  E+ IL   D 
Sbjct: 42  DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101

Query: 147 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206
            ++VK+ +SF+D   LYL+ME++PGG+M + L +    +E    FY A+ VLA+  +H L
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161

Query: 207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 266
             IHRD+KP+NLL+D +G+++++DFG                                + 
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFA-----------------------------KRV 192

Query: 267 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 326
           K  TW         +  GTP+Y+APE+ +  GYNK  DWW+LGV++YEM +G+PPF ++ 
Sbjct: 193 KGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQ 243

Query: 327 PQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFE 383
           P + Y+K+++ +  + FP +  +S   K L+      +   R G    GV +IK++ +F 
Sbjct: 244 PIQIYEKIVSGR--VRFPSK--LSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFA 299

Query: 384 GVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
              W  I E+   A    +     D SNFD++ E ++
Sbjct: 300 TTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEEL 336


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  207 bits (528), Expect = 1e-53
 Identities = 126/330 (38%), Positives = 187/330 (56%), Gaps = 46/330 (13%)

Query: 89  FESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
           FE LKV+G+G+FG+V LV+K    D+GH+YAMK+L+KA +  +++V   + ERDIL + +
Sbjct: 71  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 129

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
             +VVK+ Y+FQ +  LYLI++FL GGD+ T L K+   TEE+ +FY+AE  L +D +H 
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189

Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
           LG I+RD+KP+N+LLD +GH+KL+DFGL                              SK
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 219

Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
              +  K+     A+S  GT +Y+APEV  + G++   DWWS GV+M+EML G  PF  +
Sbjct: 220 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 274

Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFE 383
             +ET   ++  K  +   P+   +E    L   F     +R+G+   G EEIK + F+ 
Sbjct: 275 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 331

Query: 384 GVDWEHI--RERPAAISIEIKSIDDTSNFD 411
            +DW  +  RE        +   DDT  FD
Sbjct: 332 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 361



 Score =  108 bits (269), Expect = 1e-23
 Identities = 72/273 (26%), Positives = 130/273 (47%), Gaps = 50/273 (18%)

Query: 93  KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-ADSLWVVK 151
           + IG G++ E +    K T   YA+K++ K+     E++       +IL+       ++ 
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQHPNIIT 483

Query: 152 MFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHR 211
           +   + D  ++YL+ E + GG+++  ++++   +E E  F +      ++ +H  G +HR
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543

Query: 212 DIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
           D+KP N+L +D  G+   +++ DFG    L                              
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQL------------------------------ 573

Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC---S 324
                R    L  +   T +++APEV  + GY++ CD WSLG+++Y ML GY PF    S
Sbjct: 574 -----RAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS 628

Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
           +TP+E   ++ + K TL+      +SE AKDL+
Sbjct: 629 DTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 661


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  207 bits (528), Expect = 1e-53
 Identities = 126/330 (38%), Positives = 187/330 (56%), Gaps = 46/330 (13%)

Query: 89  FESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
           FE LKV+G+G+FG+V LV+K    D+GH+YAMK+L+KA +  +++V   + ERDIL + +
Sbjct: 62  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 120

Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
             +VVK+ Y+FQ +  LYLI++FL GGD+ T L K+   TEE+ +FY+AE  L +D +H 
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180

Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
           LG I+RD+KP+N+LLD +GH+KL+DFGL                              SK
Sbjct: 181 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 210

Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
              +  K+     A+S  GT +Y+APEV  + G++   DWWS GV+M+EML G  PF  +
Sbjct: 211 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 265

Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFE 383
             +ET   ++  K  +   P+   +E    L   F     +R+G+   G EEIK + F+ 
Sbjct: 266 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 322

Query: 384 GVDWEHI--RERPAAISIEIKSIDDTSNFD 411
            +DW  +  RE        +   DDT  FD
Sbjct: 323 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352



 Score =  108 bits (269), Expect = 1e-23
 Identities = 72/273 (26%), Positives = 130/273 (47%), Gaps = 50/273 (18%)

Query: 93  KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-ADSLWVVK 151
           + IG G++ E +    K T   YA+K++ K+     E++       +IL+       ++ 
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQHPNIIT 474

Query: 152 MFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHR 211
           +   + D  ++YL+ E + GG+++  ++++   +E E  F +      ++ +H  G +HR
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534

Query: 212 DIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
           D+KP N+L +D  G+   +++ DFG    L                              
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQL------------------------------ 564

Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC---S 324
                R    L  +   T +++APEV  + GY++ CD WSLG+++Y ML GY PF    S
Sbjct: 565 -----RAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS 619

Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
           +TP+E   ++ + K TL+      +SE AKDL+
Sbjct: 620 DTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 652


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score =  207 bits (526), Expect = 2e-53
 Identities = 124/368 (33%), Positives = 197/368 (53%), Gaps = 44/368 (11%)

Query: 56  GLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQ-KKDTGHV 114
           GL D   +    A A+ + E        L L DF  +  +G G FG V LVQ K +    
Sbjct: 327 GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKT 386

Query: 115 YAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDM 174
           +AMKIL+K  +++  Q  HIR+E+ I+  A S ++V+++ +F+D   LY++ME   GG++
Sbjct: 387 FAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGEL 446

Query: 175 MTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLC 234
            T+L  + +  +  T+FY A  V A   +H  G I+RD+KP+NL+LD +G+ KL DFG  
Sbjct: 447 WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF- 505

Query: 235 TGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF 294
                A +  F +                     +TW         +  GTP+Y+APE+ 
Sbjct: 506 -----AKKIGFGK---------------------KTW---------TFCGTPEYVAPEII 530

Query: 295 MQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAK 354
           +  G++   D+WSLG++MYE+L G PPF    P +TY  ++   + + FP +  I++ A 
Sbjct: 531 LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK--IAKNAA 588

Query: 355 DLILRFCCE-WEHRIG--APGVEEIKSNSFFEGVDWEHIRERPAAISI--EIKSIDDTSN 409
           +LI + C +    R+G    GV++I+ + +FEG +WE +R+      I   + S  DTSN
Sbjct: 589 NLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN 648

Query: 410 FDEFPESD 417
           FD FPE +
Sbjct: 649 FDSFPEDN 656


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,739,226
Number of Sequences: 37866
Number of extensions: 798354
Number of successful extensions: 6180
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 680
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 3439
Number of HSP's gapped (non-prelim): 2046
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.