Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 5902808

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5902808 bone morphogenetic protein 1 isoform 2 precursor
[Homo sapiens]
         (823 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...  1743   0.0  
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...  1484   0.0  
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...  1484   0.0  
gi|6912724 tolloid-like 2 [Homo sapiens]                             1121   0.0  
gi|22547221 tolloid-like 1 [Homo sapiens]                            1116   0.0  
gi|126091152 cubilin [Homo sapiens]                                   207   4e-53
gi|72384339 CUB domain containing protein 2 [Homo sapiens]            182   1e-45
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]      165   2e-40
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          157   5e-38
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]           154   2e-37
gi|13899255 membrane frizzled-related protein [Homo sapiens]          154   4e-37
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]      152   9e-37
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]           151   3e-36
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]           151   3e-36
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]           151   3e-36
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]           151   3e-36
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]           151   3e-36
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]           151   3e-36
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   147   3e-35
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   147   3e-35
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   147   3e-35
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   145   1e-34
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   145   1e-34
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   145   1e-34
gi|66864913 neuropilin 1 isoform c [Homo sapiens]                     139   1e-32
gi|66912178 neuropilin 1 isoform b [Homo sapiens]                     139   1e-32
gi|182508169 neuropilin 1 isoform a [Homo sapiens]                    139   1e-32
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]     138   2e-32
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]     138   2e-32
gi|148539844 deleted in malignant brain tumors 1 isoform c precu...   138   2e-32

>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score = 1743 bits (4515), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
           AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGLELL 720
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGLELL
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGLELL 720

Query: 721 LCPHALVDTVPAPPSALHGDTHAHTHTHVHTHCPIAQETCRGPPLGASRLSPQGPGHLTL 780
           LCPHALVDTVPAPPSALHGDTHAHTHTHVHTHCPIAQETCRGPPLGASRLSPQGPGHLTL
Sbjct: 721 LCPHALVDTVPAPPSALHGDTHAHTHTHVHTHCPIAQETCRGPPLGASRLSPQGPGHLTL 780

Query: 781 APQEGSYLDFWDTHRGDPKPRRRRKSLKTFSLTPATFRGIWAL 823
           APQEGSYLDFWDTHRGDPKPRRRRKSLKTFSLTPATFRGIWAL
Sbjct: 781 APQEGSYLDFWDTHRGDPKPRRRRKSLKTFSLTPATFRGIWAL 823


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score = 1484 bits (3842), Expect = 0.0
 Identities = 702/702 (100%), Positives = 702/702 (100%)

Query: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
           AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  177 bits (449), Expect = 4e-44
 Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 45/280 (16%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRG 557
           I S  + + ++F SD +++K GF  +FF E     +P RG
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713



 Score =  172 bits (435), Expect = 1e-42
 Identities = 94/272 (34%), Positives = 137/272 (50%), Gaps = 45/272 (16%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
           I S  + + ++F SD +++K GF  +FF  ++
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 41/117 (35%), Positives = 64/117 (54%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A + ++  G
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score = 1484 bits (3842), Expect = 0.0
 Identities = 702/702 (100%), Positives = 702/702 (100%)

Query: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
           AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  307 bits (786), Expect = 3e-83
 Identities = 160/422 (37%), Positives = 229/422 (54%), Gaps = 47/422 (11%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
           I S  + + ++F SD +++K GF  +FF + DECS+ N GGC+Q C+NT GSY+C C  G
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732

Query: 578 YELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFF 636
           + L  +K  C EA C   +T  +G+ITSP WP +YP  K C W + +   +R+ L F   
Sbjct: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792

Query: 637 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
           + E    C YD +EV  G  A + + G+FCGS+KPE + +  + M + F SDN+V +KGF
Sbjct: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852

Query: 697 KA 698
           +A
Sbjct: 853 QA 854



 Score =  206 bits (525), Expect = 5e-53
 Identities = 126/425 (29%), Positives = 188/425 (44%), Gaps = 82/425 (19%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A +         
Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA C   V    G I SPN+PD Y  
Sbjct: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
            K C W I  + G  V LTF   +IE    CAYD+LEV DG    + ++GR+CG +KP+ 
Sbjct: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
           + +T SR++L+F SD S+ + GF  +      EC    R   + + L +   +       
Sbjct: 830 VLATGSRMFLRFYSDNSVQRKGFQAS---HATECGGQVRADVKTKDLYSHAQF------- 879

Query: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
                                            YP   +C W +VA   Y + L F  FE
Sbjct: 880 -----------------------------GDNNYPGGVDCEWVIVAEEGYGVELVFQTFE 910

Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
            E    C YD++E+  G  + +   G++CGS  PE + S  +++ V+F SD+T++KKGF 
Sbjct: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970

Query: 698 AHFFS 702
             + S
Sbjct: 971 LRYTS 975



 Score =  172 bits (435), Expect = 1e-42
 Identities = 94/272 (34%), Positives = 137/272 (50%), Gaps = 45/272 (16%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
           I S  + + ++F SD +++K GF  +FF  ++
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 41/117 (35%), Positives = 64/117 (54%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A + ++  G
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score = 1121 bits (2899), Expect = 0.0
 Identities = 537/756 (71%), Positives = 608/756 (80%), Gaps = 34/756 (4%)

Query: 1   MPGVARLPLLLGLLLL---PRPG-----RPLDLADYTYDLAEEDDSEPL-NYKDPCKAAA 51
           MP    L  L+ LLLL   PR       RP   ADY+    EE   + L +Y DPCKAA 
Sbjct: 1   MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAV 60

Query: 52  FLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTN----GQPQRG 107
           F GDIALDE+DL+ F + +A D  + T   +          ++ S   T     G  + G
Sbjct: 61  FWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAG 120

Query: 108 ACGRWRGR----------------SRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVF 151
             GR                     R RRA TSR ER+WP GVIP+VIGGNFTGSQRA+F
Sbjct: 121 KDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIF 180

Query: 152 RQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIV 211
           +QAMRHWEKHTCVTF+ERTDE+S+IVF+YR CGCCSYVGRRGGGPQAISIGKNCDKFGIV
Sbjct: 181 KQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIV 240

Query: 212 VHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMH 271
            HELGHVVGFWHEHTRPDRD+HV+I+RENIQPGQEYNFLKME  EV SLGETYDFDSIMH
Sbjct: 241 AHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMH 300

Query: 272 YARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTG 331
           YARNTFSRG+FLDTI+P+ + NGV+P IGQR RLS+GDIAQARKLYKCPACGETLQD+TG
Sbjct: 301 YARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTG 360

Query: 332 NFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAP 391
           NFS+P +PNGY ++ HCVWRISVTPGEKI+LNFTS+DL++SRLCWYDYVEVRDG+WRKAP
Sbjct: 361 NFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAP 420

Query: 392 LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNY 451
           L GRFCG K+PEP+VSTDSRLWVEFRSSSN +GKGFFA YEA CGGD+ KD G IQSPNY
Sbjct: 421 LLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNY 480

Query: 452 PDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCG 511
           PDDYRPSK C+WRI VSEGFHVGLTFQ+FEIERHDSCAYDYLEVRDG +E S LIG +CG
Sbjct: 481 PDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCG 540

Query: 512 YEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYK 571
           YEKP+D+KS+S+RLW+KFVSDGSINKAGFA NFFKEVDECS P+ GGCE RC+NTLGSYK
Sbjct: 541 YEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYK 600

Query: 572 CSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISL 631
           C+CDPGYELA DK+ CE ACGGF+TKLNG+ITSPGWPKEYP NKNC+WQ+VAP QYRISL
Sbjct: 601 CACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL 660

Query: 632 QFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTV 691
           QF+ FE EGNDVCKYDFVEVRSGL+ D+KLHG+FCGSE PEVITSQ NNMRVEFKSDNTV
Sbjct: 661 QFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV 720

Query: 692 SKKGFKAHFFS-----VLEGAGDRHSHLSGLELLLC 722
           SK+GF+AHFFS       +  G +H  ++     LC
Sbjct: 721 SKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLC 756



 Score =  292 bits (748), Expect = 8e-79
 Identities = 147/421 (34%), Positives = 225/421 (53%), Gaps = 45/421 (10%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  +    G   SP YP+ Y     CVWRI+V+ G  + L F + ++ R   C YDY+E
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLE 523

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG   ++ L G FCG + PE + S+ +RLW++F S  +    GF A +          
Sbjct: 524 VRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583

Query: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
                                            E  CGG + K  G I SP +P +Y  +
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN 643

Query: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
           K C+W++     + + L F+ FE+E +D C YD++EVR G S  + L GR+CG E P+ I
Sbjct: 644 KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVI 703

Query: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
            S S+ + ++F SD +++K GF  +FF + DEC++ N GGC+  C+NT GSY C C  GY
Sbjct: 704 TSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDN-GGCQHECVNTFGSYLCRCRNGY 762

Query: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
            L  +   C EA C   ++ + G++ SP WP +YP  + C W + +   +R+ L F+ FE
Sbjct: 763 WLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFE 822

Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
            E +  C YD +E+  G  + + + G+FCGS+KP+   +  ++M + F SD +V +KGF+
Sbjct: 823 IEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882

Query: 698 A 698
           A
Sbjct: 883 A 883



 Score =  208 bits (529), Expect = 2e-53
 Identities = 127/425 (29%), Positives = 187/425 (44%), Gaps = 82/425 (19%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            ACG  +    G  +SP +P  Y  + +CVW++      +I L F   +L  + +C YD+V
Sbjct: 619  ACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFV 678

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
            EVR G    A L GRFCGS+ PE I S  + + VEF+S +    +GF A +         
Sbjct: 679  EVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAK 738

Query: 432  ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                              EA C   +    G + SPN+PD Y  
Sbjct: 739  DNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPS 798

Query: 458  SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
             + C W I  + G  V LTF  FEIE+H  CAYD+LE+ DG    + ++GR+CG +KPD 
Sbjct: 799  RRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDP 858

Query: 518  IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
              ++ S ++L+F SD S+ + GF                          + S +C     
Sbjct: 859  TVASGSSMFLRFYSDASVQRKGF------------------------QAVHSTECGGRLK 894

Query: 578  YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
             E+   +    A  G                  YP    C W +VA   Y + L F  FE
Sbjct: 895  AEVQTKELYSHAQFGD---------------NNYPSEARCDWVIVAEDGYGVELTFRTFE 939

Query: 638  TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
             E    C YD++E   G  + +   G+FCGS   E I S  +++ + F++D+T++KKGF 
Sbjct: 940  VEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFH 999

Query: 698  AHFFS 702
            A + S
Sbjct: 1000 ARYTS 1004


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score = 1116 bits (2887), Expect = 0.0
 Identities = 507/696 (72%), Positives = 598/696 (85%), Gaps = 20/696 (2%)

Query: 27  DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
           DYT+D  EED +E ++YKDPCKAA F GDIALD+EDL  FQ+ + +DL +       HT 
Sbjct: 34  DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93

Query: 80  ----------RKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRG---RSRSRRAATSRP 126
                     ++ ++   +            N   +     ++ G   ++R  RAATSR 
Sbjct: 94  GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRT 153

Query: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
           ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 154 ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCC 213

Query: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
           SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 214 SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273

Query: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
           YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P  + NG++P IGQRTRLS
Sbjct: 274 YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333

Query: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
           KGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 334 KGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393

Query: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
           +DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STDSR+W+EFRSSSNWVGKG
Sbjct: 394 MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKG 453

Query: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
           F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE +HVGLTFQSFEIERHD
Sbjct: 454 FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD 513

Query: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
           +CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 514 NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573

Query: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
           E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 574 EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633

Query: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
           WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+ SGL+++SKLHGKFC
Sbjct: 634 WPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693

Query: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
           G+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFS
Sbjct: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729



 Score =  295 bits (756), Expect = 9e-80
 Identities = 154/421 (36%), Positives = 223/421 (52%), Gaps = 45/421 (10%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++ + G   SP YP+ Y     CVW+I+V+    + L F S ++ R   C YDY+E
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG    +PL GRFCG   PE I ST + LW++F S       GF A +          
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581

Query: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
                                            EA CGG + K  G I +P +P +Y P+
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641

Query: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
           K C+W++     + + + F+ FE+E ++ C YDY+E+  G S  S L G++CG E P+ I
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701

Query: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
            S  + + ++F SD +++K GF  +FF + DECS+ N GGC+  C+NT+GSY C C  G+
Sbjct: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQHECVNTMGSYMCQCRNGF 760

Query: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
            L  +K  C EA C   +   +G ITSP WP +YP  K C W++ A   +RI L F  FE
Sbjct: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820

Query: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
            E +  C YD +EV  G T  S + G+ CG++ P+ + +  N M V F SD +V +KGF+
Sbjct: 821 IEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880

Query: 698 A 698
           A
Sbjct: 881 A 881



 Score =  209 bits (532), Expect = 8e-54
 Identities = 127/426 (29%), Positives = 191/426 (44%), Gaps = 82/426 (19%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            ACG  L    G  ++P +P  Y  + +CVW++      +I + F   +L  + +C YDYV
Sbjct: 617  ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
            E+  G   ++ L G+FCG+++PE I S  + + +EF+S +    KGF A +         
Sbjct: 677  EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736

Query: 432  ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                              EA C   +    G I SPN+PD Y  
Sbjct: 737  DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796

Query: 458  SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
             K C W I  + G  + L F  FEIE+H  CAYD+LEV DG +E S ++GR CG + PD 
Sbjct: 797  RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856

Query: 518  IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
            + +T ++++++FVSD S+ + GF                            S +C     
Sbjct: 857  LVATGNKMFVRFVSDASVQRKGFQATH------------------------STECGGRLK 892

Query: 578  YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
             E  P      A  G                  YP   +C W LV+    R+ L F  FE
Sbjct: 893  AESKPRDLYSHAQFGD---------------NNYPGQVDCEWLLVSERGSRLELSFQTFE 937

Query: 638  TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
             E    C YD+VE+  GL + +   G+FCGS  PE I S  +++ + F +D+T++KKGF 
Sbjct: 938  VEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFH 997

Query: 698  AHFFSV 703
              + S+
Sbjct: 998  IRYKSI 1003



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 47/121 (38%), Positives = 71/121 (58%), Gaps = 1/121 (0%)

Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
           RC A CG  L + NG+++SPG+P  YP   +CIW++      +I L F   +   + +C 
Sbjct: 345 RCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403

Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
           YD++EVR G    S L G+FCG + PEV+TS  + M +EF+S +    KGF A + ++  
Sbjct: 404 YDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICG 463

Query: 706 G 706
           G
Sbjct: 464 G 464


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score =  207 bits (526), Expect = 4e-53
 Identities = 136/465 (29%), Positives = 208/465 (44%), Gaps = 77/465 (16%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY-DY 379
            AC +   D  G F+SP +PN Y  +  C++RI+V  G+ I ++FT+  L  +   +Y D+
Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106

Query: 380  VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---CG 436
            +E+RDG + K+PL G F GS LP  I+S  ++LW++F+S       GF A ++     CG
Sbjct: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166

Query: 437  GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVR 496
            G++    G   SPNYP  Y  S  C W ++ S G    L F+ F +E H +C  DYL V 
Sbjct: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226

Query: 497  DGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF------------ 544
            DG S +S L+ + CG EKP  I+S+   +++K  +D      GF   +            
Sbjct: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQ 1286

Query: 545  -FKEVDECSRPNRGGCEQRCLNTLGS----------------YKCSCDPGY-ELAPDKRR 586
             +  ++    PN     Q C  T+ +                +  +C   Y EL    R+
Sbjct: 1287 TYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQ 1346

Query: 587  CEAACG----------------------------GF------------LTKLNGSITSPG 606
                CG                            GF            L+   GS +SPG
Sbjct: 1347 MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPG 1406

Query: 607  WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
            +P  YPPNK CIW +       I L    F+ E +  C +D +E+  G    S    + C
Sbjct: 1407 FPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLC 1466

Query: 667  GSEKPE---VITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
                PE    ++S  N + + FK+D +++ +GF A + +V  G G
Sbjct: 1467 TQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCG 1511



 Score =  205 bits (522), Expect = 1e-52
 Identities = 128/386 (33%), Positives = 180/386 (46%), Gaps = 49/386 (12%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG   Q  +G   SP YP+ Y ++  C W I V    +++LNFT  DL     C   Y  
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567

Query: 382  VRDGFWRKAPLRGRFCG-SKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV- 439
              DG         R CG  +L  PIVS+ + L++ F+S  +   +GF A +   CGG + 
Sbjct: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625

Query: 440  KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGF-HVGLTFQSFEIERHDSCAYDYLEVRDG 498
               +  + SP +P +Y  ++ C W IQ      H+ L+F  FE+ER  +CA D++E+ DG
Sbjct: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685

Query: 499  HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
              E + L GRYCG + P  I S SS L L+FVSD SI+  GF       V          
Sbjct: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASV---------- 1735

Query: 559  CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCI 618
                                          +ACGG      G   SPG+P  YPPN  C+
Sbjct: 1736 ------------------------------SACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765

Query: 619  WQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY 678
            W +V+    R+ L F  F+ E +  C  DFVE+R G  A   L G++CG+  P   +S  
Sbjct: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824

Query: 679  -NNMRVEFKSDNTVSKKGFKAHFFSV 703
             + + V F SD + S  GF+A F  +
Sbjct: 1825 GHTLWVRFISDGSGSGTGFQATFMKI 1850



 Score =  198 bits (503), Expect = 2e-50
 Identities = 130/407 (31%), Positives = 192/407 (47%), Gaps = 55/407 (13%)

Query: 303  TRLSKGDIAQARKLYKCPACG-ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPG-EKI 360
            +R ++G  AQ R+     ACG   L  S    SSP +P  Y  + +C W I   P    I
Sbjct: 1606 SRQNRGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHI 1660

Query: 361  ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
             L+FT  +L RS  C  D+VE+ DG    APLRGR+CG+ +P PI S  S L + F S S
Sbjct: 1661 TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDS 1720

Query: 421  NWVGKGFFAVYEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
            +    GF     A    CGG      G   SP YPD Y P+  C+W I  S G  + L+F
Sbjct: 1721 SISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSF 1780

Query: 478  QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS-TSSRLWLKFVSDGSIN 536
             SF++E    C+ D++E+R+G++ +  L+GRYCG   P +  S     LW++F+SDGS +
Sbjct: 1781 ISFQLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGS 1839

Query: 537  KAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLT 596
              GF   F K                  N +G++                          
Sbjct: 1840 GTGFQATFMKIFGND-------------NIVGTH-------------------------- 1860

Query: 597  KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656
               G + SP WP+ YP N N  W +     + +  +    + E    C YD + +  G +
Sbjct: 1861 ---GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917

Query: 657  ADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
              ++L G +CG++  E  +S  N++   F SD+++S KGF   +F+V
Sbjct: 1918 IHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWFAV 1963



 Score =  192 bits (487), Expect = 1e-48
 Identities = 123/384 (32%), Positives = 179/384 (46%), Gaps = 56/384 (14%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  +TG+FSSP +PN Y  +  C+W I   PG  I L     D+     C +D +E
Sbjct: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450

Query: 382  VRDGFWRKAPLRGRFCGSKLPE---PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI---C 435
            +  G    +P   + C  + PE    + ST + L + F++  +  G+GF A ++A+   C
Sbjct: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510

Query: 436  GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
            GG  +   G I SPNYP  YR +  C W I+V     V L F  F++E  DSC   Y   
Sbjct: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567

Query: 496  RDGHSESSTLIGRYCGYEK-PDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
             DG S + + + R CG E+  + I S+ + L+L+F S  S    GF   F          
Sbjct: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616

Query: 555  NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWPKEYPP 613
                                               ACGG  LT    +++SP +P  YP 
Sbjct: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643

Query: 614  NKNCIWQLVA-PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPE 672
            N+NC W + A P    I+L F  FE E +  C  DFVE+  G   D+ L G++CG++ P 
Sbjct: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703

Query: 673  VITSQYNNMRVEFKSDNTVSKKGF 696
             ITS  + + + F SD+++S  GF
Sbjct: 1704 PITSFSSALTLRFVSDSSISAGGF 1727



 Score =  189 bits (480), Expect = 9e-48
 Identities = 125/391 (31%), Positives = 182/391 (46%), Gaps = 48/391 (12%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            ACGE L +STG   SP +PN Y   ++C W I V P   I L F +  L     C  DY+
Sbjct: 931  ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-----C 435
            EV D     +   GR+CG  +P  + S+ + L + F + S+   +GF   YEAI     C
Sbjct: 991  EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048

Query: 436  GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYLE 494
              D   D G   SPN+P++Y  +  CI+RI V  G  + + F +F +E      Y D+LE
Sbjct: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            +RDG  E S L+G + G   P  I S S++LWLKF SD    ++GF+  +          
Sbjct: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWD--------- 1159

Query: 555  NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
                         GS                     CGG LT  +G+  SP +P  Y  +
Sbjct: 1160 -------------GS------------------STGCGGNLTTSSGTFISPNYPMPYYHS 1188

Query: 615  KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
              C W L +       L+F  F  E +  C  D++ V  G +++S L  + CG EKP +I
Sbjct: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248

Query: 675  TSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
             S  ++M ++ ++D     +GFKA +    E
Sbjct: 1249 RSSGDSMFIKLRTDEGQQGRGFKAEYRQTCE 1279



 Score =  184 bits (468), Expect = 2e-46
 Identities = 131/412 (31%), Positives = 185/412 (44%), Gaps = 50/412 (12%)

Query: 311  AQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY 370
            A  R +Y+  ACG+ L    G   SP +PN Y     C W I     + I+LNFT  ++ 
Sbjct: 807  ASFRAVYQV-ACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864

Query: 371  RSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
             S  C  DYVE+       +P   ++CG+ +P  I S  + L+V F  SS+    GF A 
Sbjct: 865  SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924

Query: 431  YEA---ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
            + A    CG  + +  G IQSP +P+ Y     C W I V     + L F++F +E H +
Sbjct: 925  FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984

Query: 488  CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547
            C  DYLEV D  SE+S  +GRYCG   P  + S+ + L L FV+D  +   GF +N+   
Sbjct: 985  CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039

Query: 548  VDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGW 607
                                               +      AC    T   G+ TSP +
Sbjct: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064

Query: 608  PKEYPPNKNCIWQLVAPTQYRISLQFDFFETE---GNDVCKYDFVEVRSGLTADSKLHGK 664
            P  YP N  CI+++   T   I++ F  F  E   GN     DF+E+R G    S L G 
Sbjct: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT--DFLEIRDGGYEKSPLLGI 1122

Query: 665  FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSG 716
            F GS  P  I S  N + ++FKSD   ++ GF A++     G G   +  SG
Sbjct: 1123 FYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSG 1174



 Score =  183 bits (465), Expect = 5e-46
 Identities = 124/396 (31%), Positives = 184/396 (46%), Gaps = 57/396 (14%)

Query: 321  ACGETLQ--DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
            ACG  L+  D+     SP +P+ YS  + C W I   P   + LN  SLD+   R C YD
Sbjct: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035

Query: 379  YVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
             + +RDG    A      CG ++P PI ST   +++ F S S+    GF A +   CGG 
Sbjct: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095

Query: 439  VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDSCAY--DYLEV 495
            +  D G I SP YP+ Y  +  C W + V  G  + + F Q F+I   DS     DYL +
Sbjct: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155

Query: 496  RDGHSESSTLI------GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
            R+G    S  +      G +CG      + ++ ++++++F+SD S    GF + +     
Sbjct: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210

Query: 550  ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFL----TKLNGSITSP 605
                      E + L                         ACGG +        G +TSP
Sbjct: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235

Query: 606  GWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
              P  YPP+ +CIW L AP + RI LQF D F+ E    C  +++E+R G+ +D+ +  K
Sbjct: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295

Query: 665  FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            FCG+  P    S    M + F+SDN+ +  GFKA +
Sbjct: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331



 Score =  183 bits (465), Expect = 5e-46
 Identities = 117/393 (29%), Positives = 185/393 (47%), Gaps = 49/393 (12%)

Query: 318  KCPACGETLQ----DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS-LDLYRS 372
            K  ACG  +     DS G  +SP +P+ Y  H  C+W ++  P  +I L F    D+  +
Sbjct: 2213 KSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVT 2272

Query: 373  RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
              C  +Y+E+RDG    AP+  +FCG+ LP    S+   +++ FRS ++    GF A Y 
Sbjct: 2273 PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS 2332

Query: 433  -AICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
             A CGG V    G ++S  +P   YR +  C W +Q   G ++ ++F+ F ++    C  
Sbjct: 2333 IAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEK 2392

Query: 491  DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
            D++E+ D H+ S  ++GRYCG   PD I ++S+   ++FV+DGS+  +GF + F   ++E
Sbjct: 2393 DFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE 2451

Query: 551  CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
                                                    CGG L    G+ TSP +P  
Sbjct: 2452 ----------------------------------------CGGDLQGSIGTFTSPNYPNP 2471

Query: 611  YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGS-E 669
             P  + C W++ AP   RI+L F+      +  C  + V V +G+ ++S    K C S  
Sbjct: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531

Query: 670  KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
                I S  N M+V F +D +    GF A + S
Sbjct: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS 2564



 Score =  171 bits (432), Expect = 3e-42
 Identities = 118/410 (28%), Positives = 178/410 (43%), Gaps = 49/410 (11%)

Query: 292 VNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWR 351
           V+GV     + TRL  G + Q  +      CGE+L    G+FS      GY   ++C W 
Sbjct: 448 VDGVDSFSCECTRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWV 503

Query: 352 ISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSR 411
           I    G+ + + FT   L     C +++++V DG    A   GRFCGS LP  ++S+D+ 
Sbjct: 504 IKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNA 563

Query: 412 LWVEFRSSSNWVGKGFFAVYEAI---CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVS 468
           L+    S     G+GF   +E     CGG +   YG I+SP YP +Y P + C+W +  S
Sbjct: 564 LYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTS 623

Query: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
               V  TF +  +E HD C  DYLE+RDG      L+G++C       +++T     + 
Sbjct: 624 PDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIH 683

Query: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
           F SD  I+  GF +                                   Y  +P   R  
Sbjct: 684 FHSDSQISDQGFHIT----------------------------------YLTSPSDLR-- 707

Query: 589 AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
             CGG  T   G +  P     +   + C++ +  P   +I + F   E +       ++
Sbjct: 708 --CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765

Query: 649 VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA 698
           +EVR G T    L GK CG+     I S  N++ + FK D +V K  F+A
Sbjct: 766 IEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRA 811



 Score =  169 bits (427), Expect = 1e-41
 Identities = 122/392 (31%), Positives = 177/392 (45%), Gaps = 54/392 (13%)

Query: 322  CGETLQDST-GNFSSPEYPN--GYSAHMHCVWRISVTPGE---KIILNFTSLDLYRSRLC 375
            CG +L ++  GNF+SP Y     YS +++C W +S  P +    I ++F    L   + C
Sbjct: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLS-NPNQGNSSISIHFEDFYLESHQDC 2628

Query: 376  WYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
             +D +E R G     PL  R CG   P  P+V   S++W+ F ++      GF A Y   
Sbjct: 2629 QFDVLEFRVGD-ADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT 2687

Query: 435  -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
             CGG    D G I SPNYP+ Y     C   ++  +G  + LTF  F+IE H +CA+D +
Sbjct: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747

Query: 494  EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
             VR+G S  S +IG+YCG   P  I+S S++L + F SD S+   GF   +  +      
Sbjct: 2748 TVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ------ 2801

Query: 554  PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                        TLG                      CGG     NG+I SP WP+ +P 
Sbjct: 2802 ------------TLG----------------------CGGIFHSDNGTIRSPHWPQNFPE 2827

Query: 614  NKNCIWQLVAPTQYRISLQFD--FFETEGNDVCKYDFVEVRSGL-TADSKLHGKFCGSEK 670
            N  C W  +      + + FD  F    G+  C+  FV+V +G    D  L    CG+  
Sbjct: 2828 NSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVA 2887

Query: 671  PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            P  + +  N     F+S    + +GF A F S
Sbjct: 2888 PGPVITPSNTFTAVFQSQEAPA-QGFSASFVS 2918



 Score =  163 bits (413), Expect = 5e-40
 Identities = 115/390 (29%), Positives = 174/390 (44%), Gaps = 49/390 (12%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLY-RSRL---CWY 377
            CG      +G   SP YP  Y  +M+C + I   P   ++L F S  L  RS +   C  
Sbjct: 2920 CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVN 2979

Query: 378  DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
            D V +  G+   +      CG ++P P+      L + F S+      GF   Y  I CG
Sbjct: 2980 DGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCG 3038

Query: 437  GDVKKDYGHIQSPNYP-DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
            G      G I SP Y   DY     C++ I VS+   + L F  F++    SC++DYL +
Sbjct: 3039 GVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAI 3098

Query: 496  RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
             DG + S  L+G++CG ++P ++KS+++ + L F +D      G+ ++F           
Sbjct: 3099 YDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF----------- 3147

Query: 556  RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE--YPP 613
                      TLG                   +  CGG+LT  N +  SP       Y  
Sbjct: 3148 --------RQTLGP------------------QQGCGGYLTGSNNTFASPDSDSNGMYDK 3181

Query: 614  NKNCIWQLVAPTQYRISLQFDFFETEGNDV---CKYDFVEVRSGLTADSKLHGKFCGSEK 670
            N NC+W ++AP    I L F+ F  E       C YD+V++  G + ++ L G FCGS  
Sbjct: 3182 NLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTV 3241

Query: 671  PEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            P    S  N + V+F SD T+ ++GF A +
Sbjct: 3242 PAPFISSGNFLTVQFISDLTLEREGFNATY 3271



 Score =  159 bits (403), Expect = 8e-39
 Identities = 105/382 (27%), Positives = 165/382 (43%), Gaps = 47/382 (12%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG    D  G    PE    ++    CV+ +    GE+I +NFT ++L        +Y+E
Sbjct: 708  CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
            VRDG      L G+ CG+     I S  + +W+ F+  ++     F AVY+  CG ++  
Sbjct: 768  VRDG----ETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTG 823

Query: 442  DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
            + G I+SP +P+ Y   + C W I   +   + L F  FEI     C  DY+E+      
Sbjct: 824  E-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSIL 882

Query: 502  SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQ 561
             S    +YCG + P  I S  + L++ FV   S    GF   F  E              
Sbjct: 883  GSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE-------------- 928

Query: 562  RCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
                                      + ACG  LT+  G+I SPG P  YP   NC W +
Sbjct: 929  --------------------------DLACGEILTESTGTIQSPGHPNVYPHGINCTWHI 962

Query: 622  VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNM 681
            +    + I L F+ F  E +  C  D++EV    T      G++CG   P  +TS  N++
Sbjct: 963  LVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSL 1020

Query: 682  RVEFKSDNTVSKKGFKAHFFSV 703
             + F +D+ ++ +GF  ++ ++
Sbjct: 1021 MLVFVTDSDLAYEGFLINYEAI 1042



 Score =  158 bits (400), Expect = 2e-38
 Identities = 111/406 (27%), Positives = 183/406 (45%), Gaps = 61/406 (15%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS---LDLYRSRLCWY 377
            +CG  L    G  +SP+YP  Y ++++C W + V  G  I ++F     +    S     
Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150

Query: 378  DYVEVRDGFWRKAPL------RGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
            DY+ +R+G    +P        G FCGS     + ++D++++V+F S  +  G+GF   Y
Sbjct: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210

Query: 432  EA---ICGGDV----KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIE 483
            EA    CGG+V        G++ SPN+P +Y P   CIW +       + L F+  F+IE
Sbjct: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270

Query: 484  RHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVN 543
               +C  +YLE+RDG    + ++ ++CG   P    S+   ++L+F SD S    GF   
Sbjct: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330

Query: 544  FFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSIT 603
            +                                            A CGG +   +G + 
Sbjct: 2331 Y------------------------------------------SIAQCGGRVPGQSGVVE 2348

Query: 604  SPGWPK-EYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLH 662
            S G P   Y  N  C W L   + + +++ F+ F  + +  C+ DFVE+    T+ + L 
Sbjct: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNIL- 2407

Query: 663  GKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
            G++CG+  P+ I +  N   V F +D +V+  GF+  F S +E  G
Sbjct: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECG 2453



 Score =  157 bits (398), Expect = 3e-38
 Identities = 113/398 (28%), Positives = 175/398 (43%), Gaps = 53/398 (13%)

Query: 322  CGETLQDSTGNFSSPEYPNG--YSAHMHCVWRISVTPGEKII-LNFTSLDLYRS---RLC 375
            CG  L  S   F+SP+  +   Y  +++CVW I + P  K+I L F +  L  +   + C
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVW-IIIAPVNKVIHLTFNTFALEAASTRQRC 3215

Query: 376  WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
             YDYV++ DG    A L G FCGS +P P +S+ + L V+F S      +GF A Y  + 
Sbjct: 3216 LYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275

Query: 435  --CGGDVKKDYG--HIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY 490
              CGG     +   +I SPN  D   P  +C W I       V +T  + ++   D C  
Sbjct: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQ 3334

Query: 491  DYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
            +YL+++D          ++CG          SS      +    +      ++F  ++ +
Sbjct: 3335 NYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIAD 3394

Query: 551  CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
            C+R                                           K  G++ SPGWP  
Sbjct: 3395 CNRDYH----------------------------------------KAFGNLRSPGWPDN 3414

Query: 611  YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
            Y  +K+C   L AP  + ISL F     E +  C+ DF+EVR+G  ++S L GK+CG+  
Sbjct: 3415 YDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLL 3474

Query: 671  PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
            P  + SQ N + + FKSD+  S +G++  + S   G G
Sbjct: 3475 PNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCG 3512



 Score =  157 bits (396), Expect = 5e-38
 Identities = 111/395 (28%), Positives = 173/395 (43%), Gaps = 70/395 (17%)

Query: 331  GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
            G  +SP +P  Y  + +  W ++V     +      +D+   + C+YD + + DG    A
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920

Query: 391  PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI--------------CG 436
             L G +CG++  E   ST + L   F S S+  GKGF   + A+              CG
Sbjct: 1921 RLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACG 1979

Query: 437  GDVKKDYGHIQ--SPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            G ++     +   SP +PD Y     C W IQ  +   V L   S +IE H +CAYD L 
Sbjct: 1980 GFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDSLV 2038

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            +RDG +  +  +   CG E P  I+ST   ++++F SD S+ +AGF  +F K        
Sbjct: 2039 IRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK-------- 2090

Query: 555  NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
                                               +CGG+L    G ITSP +P+ YP N
Sbjct: 2091 -----------------------------------SCGGYLHADRGIITSPKYPETYPSN 2115

Query: 615  KNCIWQLVAPTQYRISLQFD--FFETEGNDVCKY-DFVEVRSGLTADSKL------HGKF 665
             NC W ++  +   I++ F+  F    G+  C   D++ +R+G    S        +G F
Sbjct: 2116 LNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHF 2175

Query: 666  CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            CGS     + +  N M V+F SD++   +GFK  +
Sbjct: 2176 CGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210



 Score =  149 bits (376), Expect = 1e-35
 Identities = 112/398 (28%), Positives = 171/398 (42%), Gaps = 54/398 (13%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  LQ S G F+SP YPN       C WRI+   G +I L F +L L     C  ++V 
Sbjct: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511

Query: 382  VRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----EAICG 436
            V +G    +P   + C S  +   I S+ + + V F +  +    GF A Y    +A+CG
Sbjct: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCG 2571

Query: 437  GDVKKD-YGHIQSPNYPD--DYRPSKVCIWRIQVSE--GFHVGLTFQSFEIERHDSCAYD 491
            G +     G+  SP Y    +Y  +  C W +         + + F+ F +E H  C +D
Sbjct: 2572 GSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFD 2631

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
             LE R G ++   L+ R CG  KP   +    S++W+ FV++  +   GF   +      
Sbjct: 2632 VLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------ 2684

Query: 551  CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
                                                    CGG     +G ITSP +P  
Sbjct: 2685 ------------------------------------SFTDCGGIQIGDSGVITSPNYPNA 2708

Query: 611  YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
            Y    +C   L AP  + I+L F  F+ E +  C +D V VR+G + +S + G++CG+  
Sbjct: 2709 YDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSN 2768

Query: 671  PEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAG 708
            P  I S  N + V F SD+++   GF A + +   G G
Sbjct: 2769 PRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCG 2806



 Score =  148 bits (373), Expect = 2e-35
 Identities = 105/395 (26%), Positives = 171/395 (43%), Gaps = 52/395 (13%)

Query: 317  YKCPACGETLQDSTGNFSSPEYPN-GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
            Y    CG  +   +G   S  +P   Y  ++ C W +    G  + ++F   +L  S  C
Sbjct: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390

Query: 376  WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
              D+VE+ D       + GR+CG+ +P+ I ++ +   V F +  +    GF   +E+  
Sbjct: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449

Query: 435  --CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
              CGGD++   G   SPNYP+     ++C WRI   EG  + L F +  +  H SC  ++
Sbjct: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509

Query: 493  LEVRDGHSESSTLIGRYC-GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
            + V +G   +S  + + C      ++IKS+ + + + F +DGS    GF  ++    D  
Sbjct: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567

Query: 552  SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL-NGSITSPGWP-- 608
                                                 A CGG L     G+ TSPG+   
Sbjct: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590

Query: 609  KEYPPNKNCIWQLVAPTQ--YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
            + Y  N NC W L  P Q    IS+ F+ F  E +  C++D +E R G  AD  L  + C
Sbjct: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649

Query: 667  GSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            G  KP + +   Y+ + + F ++  V   GF A +
Sbjct: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684



 Score =  137 bits (344), Expect = 5e-32
 Identities = 103/372 (27%), Positives = 161/372 (43%), Gaps = 49/372 (13%)

Query: 332  NFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAP 391
            N SSP   +       C W I   P +++ +   +L L  S+ C  +Y++++D       
Sbjct: 3290 NISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQL-TSQDCTQNYLQLQDSPQGHGN 3348

Query: 392  LRGRFCGSKLPEPIV--STDSRLWVEFRSSS-NWVGKGFFAVYEAICGGDVKKDYGHIQS 448
             R +FCG       V  S+ S   V F+S   N   +  F    A C  D  K +G+++S
Sbjct: 3349 SRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRS 3408

Query: 449  PNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGR 508
            P +PD+Y   K C   +   +   + L F S  IE    C  D+LEVR+G + +S L+G+
Sbjct: 3409 PGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGK 3468

Query: 509  YCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLG 568
            YCG   P+ + S ++ L+L+F SD   +  G+      E+   S P              
Sbjct: 3469 YCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY------EIIWTSSP-------------- 3508

Query: 569  SYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYR 628
                                + CGG L    GS TSPG+P  YP N  C W LVAP    
Sbjct: 3509 --------------------SGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRL 3548

Query: 629  ISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSE---KPEVITSQYNNMRVEF 685
            +++ F F   +    C  +++ +  G  A S   G +CG +    P V +S  N + ++F
Sbjct: 3549 VTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASS--NQVFIKF 3606

Query: 686  KSDNTVSKKGFK 697
             +D       F+
Sbjct: 3607 HADYARRPSAFR 3618



 Score =  128 bits (322), Expect = 2e-29
 Identities = 100/391 (25%), Positives = 160/391 (40%), Gaps = 52/391 (13%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR--LCWYDY 379
            CG       G   SP +P  +  +  C W       + + ++F +  L  S    C   +
Sbjct: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864

Query: 380  VEVRDGFWR-KAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGD 438
            V+V  G       L    CG+  P P+++  +     F+S      +GF A + + CG +
Sbjct: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923

Query: 439  VKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----SCAYDYLE 494
                 G+I SPNYP  Y  +  C + I+ +    V LTF SF +E       SC  D + 
Sbjct: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            +  G+S  ST     CG E P  + + +  + L F S+  I   GF              
Sbjct: 2984 IIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKF------------ 3030

Query: 555  NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
                          SY+                  +CGG     +G ITSP +   +YP 
Sbjct: 3031 --------------SYRI----------------ISCGGVFNFSSGIITSPAYSYADYPN 3060

Query: 614  NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
            + +C++ +       I L+F  F+   +  C +D++ +  G      L GKFCGS++P  
Sbjct: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120

Query: 674  ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL 704
            + S  N+M + FK+D+  + KG+K  F   L
Sbjct: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151



 Score =  125 bits (315), Expect = 1e-28
 Identities = 101/391 (25%), Positives = 155/391 (39%), Gaps = 55/391 (14%)

Query: 317  YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
            Y    CG      +G  +SP YPN Y +  HC   +    G  I L F+  D+     C 
Sbjct: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743

Query: 377  YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
            +D V VR+G   ++P+ G++CG+  P  I S  ++L V F S  +  G GF+A +     
Sbjct: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803

Query: 435  -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHD-SCAYD 491
             CGG    D G I+SP++P ++  +  C W     +  H+ ++F  +F I   D  C   
Sbjct: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863

Query: 492  YLEVRDGHSE-SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
            +++V  G  E    L+   CG   P  + + S+     F S       GF+ +F      
Sbjct: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV----- 2917

Query: 551  CSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKE 610
                                                  + CG   T  +G I SP +PK+
Sbjct: 2918 --------------------------------------SRCGSNFTGPSGYIISPNYPKQ 2939

Query: 611  YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDV----CKYDFVEVRSGLTADSKLHGKFC 666
            Y  N NC + + A     + L F  F  E        C  D V +  G +  S      C
Sbjct: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999

Query: 667  GSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
            G E P  +T     + + F S+  ++  GFK
Sbjct: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFK 3029



 Score =  123 bits (309), Expect = 6e-28
 Identities = 98/415 (23%), Positives = 171/415 (41%), Gaps = 54/415 (13%)

Query: 317  YKCPACGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
            Y+  +CG     S+G  +SP Y    Y   MHC++ I+V+  + I L F+  D+  S  C
Sbjct: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091

Query: 376  WYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI- 434
             +DY+ + DG     PL G+FCGSK P  + S+++ + + F++ S    KG+   +    
Sbjct: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151

Query: 435  -----CGGDVKKDYGHIQSPNYPDD--YRPSKVCIWRIQVSEGFHVGLTFQSFEIE---R 484
                 CGG +        SP+   +  Y  +  C+W I       + LTF +F +E    
Sbjct: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211

Query: 485  HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
               C YDY+++ DG SE++ L G +CG   P    S+ + L ++F+SD ++ + GF   +
Sbjct: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271

Query: 545  FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
                  C                G+Y  +  P                        +I+S
Sbjct: 3272 TIMDMPCG---------------GTYNATWTP-----------------------QNISS 3293

Query: 605  PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
            P       P   C W + +P   ++ +     +    D C  ++++++           +
Sbjct: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352

Query: 665  FCG--SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGL 717
            FCG  +    V  S  +   V FKS   V++    +  + + +   D H     L
Sbjct: 3353 FCGRNASAVPVFYSSMSTAMVIFKS-GVVNRNSRMSFTYQIADCNRDYHKAFGNL 3406



 Score =  117 bits (293), Expect = 4e-26
 Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 4/232 (1%)

Query: 317  YKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
            Y+   C      + GN  SP +P+ Y     C   ++      I L F SL +  S  C 
Sbjct: 3390 YQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECR 3449

Query: 377  YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-- 434
             D++EVR+G    +PL G++CG+ LP P+ S ++ L++ F+S S    +G+  ++ +   
Sbjct: 3450 NDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPS 3509

Query: 435  -CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
             CGG +  D G   SP YP  Y  +  C W +    G  V + F    I+    C  +YL
Sbjct: 3510 GCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYL 3569

Query: 494  EVRDGHSESSTLIGRYCGYEKP-DDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
             + DG + SS   G YCG +       ++S+++++KF +D +   + F + +
Sbjct: 3570 TLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621


>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
          Length = 449

 Score =  182 bits (461), Expect = 1e-45
 Identities = 127/440 (28%), Positives = 190/440 (43%), Gaps = 57/440 (12%)

Query: 305 LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
           L  G  AQA +  KC   G  L   +GNFSSP +P  Y  +  C W I V  G  ++L F
Sbjct: 16  LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72

Query: 365 TSLDLYRSRLCWYDYVEVRDGFW-RKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            + DL     C +D++E+ +G    K  L GRFCG   P P  S+   + V F S  +  
Sbjct: 73  HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132

Query: 424 GKGFFAVYEA-ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482
             GF A Y+  +CGG +    G + SP YP++Y  S  C W I+ +   HV L F  F++
Sbjct: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192

Query: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV 542
           E ++ C YDY+ V  G     T    YCG  +P  + S    L + F SD +I   GF  
Sbjct: 193 EGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250

Query: 543 NFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSI 602
            +F           G C++                                    + G+ 
Sbjct: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268

Query: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV---CKYDFVEVRSGLTAD 658
           +SP +P  YP N  C W +  P  Y++ + F D    E N +   C +D +    G + +
Sbjct: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328

Query: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGLE 718
           + L G +CG   P  +TS +N + +   +D + +++GF   +     G G   +   G  
Sbjct: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTEGEGEA 388

Query: 719 L----LLCPHALVDTVPAPP 734
           L    L  P ++    PAPP
Sbjct: 389 LQPQSLQSPSSIPPVCPAPP 408


>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
          Length = 449

 Score =  165 bits (417), Expect = 2e-40
 Identities = 93/275 (33%), Positives = 144/275 (52%), Gaps = 36/275 (13%)

Query: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYL 493
           +CGGDVK + G++ S  +P+ Y P+K CIW I V EG  V L+F+ F++E H +C YD L
Sbjct: 36  LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95

Query: 494 EVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
           EV  G   S   +GR+CG  +P  + +  +++ L+  +D      GF + +       S 
Sbjct: 96  EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY-------SG 148

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK-EYP 612
               G E +                            CGG L K  G++T+P WP+ +YP
Sbjct: 149 RATSGTEHQF---------------------------CGGRLEKAQGTLTTPNWPESDYP 181

Query: 613 PNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG-LTADSKLHGKFCGSEKP 671
           P  +C W ++AP    I+L F+ F+ E +  C+YD V V +G ++ DS+  GKFCG   P
Sbjct: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241

Query: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
             I+S+ N + V+F SD +V+  GF A + ++  G
Sbjct: 242 GSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276



 Score =  134 bits (338), Expect = 3e-31
 Identities = 74/234 (31%), Positives = 118/234 (50%), Gaps = 11/234 (4%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++  +G  +S  +PN Y  +  C+W I+V  G+ + L+F   DL     C YD +E
Sbjct: 37  CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
           V  G        GRFCG+  P P+V+  +++ +   +     G+GF   Y          
Sbjct: 97  VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156

Query: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
             CGG ++K  G + +PN+P+ DY P   C W I       + LTF+ F++E    C YD
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216

Query: 492 YLEVRDGH-SESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
            + V +G  S+ S  +G++CG   P  I S  + L ++FVSD S+   GF+ ++
Sbjct: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASY 270



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 1/135 (0%)

Query: 582 PDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN 641
           P+  R    CGG +   +G + S G+P  YPPNK CIW +  P    +SL F  F+ E +
Sbjct: 28  PNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELH 87

Query: 642 DVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701
             C+YD +EV +G     +  G+FCG+ +P  + +  N + +   +D     +GF   ++
Sbjct: 88  PACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLL-WY 146

Query: 702 SVLEGAGDRHSHLSG 716
           S    +G  H    G
Sbjct: 147 SGRATSGTEHQFCGG 161



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 41/125 (32%), Positives = 57/125 (45%), Gaps = 2/125 (1%)

Query: 322 CGETLQDSTGNFSSPEYPNG-YSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           CG  L+ + G  ++P +P   Y   + C W I   P + I L F   DL     C YD V
Sbjct: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218

Query: 381 EVRDGFWRKAPLR-GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDV 439
            V +G       R G+FCG  +P  I S  + L V+F S  +    GF A Y+ +  G  
Sbjct: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTA 278

Query: 440 KKDYG 444
           K+  G
Sbjct: 279 KEGQG 283


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  157 bits (396), Expect = 5e-38
 Identities = 138/500 (27%), Positives = 203/500 (40%), Gaps = 98/500 (19%)

Query: 290 YEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCV 349
           Y + G K    QR   +    +  R + +   CG  L+  +G  +SP YP  Y  + HCV
Sbjct: 380 YVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439

Query: 350 WRISVTPGEKII-LNFTSLDLYRSRLCWYDYVEVRDG--FWRKAPLRGRFCGSKLPEPIV 406
           W I+ T  +K+I L F   +L R     YD + V D         +     GS +P+ IV
Sbjct: 440 WVITTTDPDKVIKLAFEEFELERG----YDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495

Query: 407 STDSRLWVEFRSSSNWVGKGFFAVYEAI----CGGDVKKDYGH----------------- 445
           S  +++W+  +S  +    GF AVY+ I    CG      YG                  
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECP 555

Query: 446 ------------IQSPNYPDDYRPSKV--CIWRIQVSEGF-------------------- 471
                        Q  N     +PS V  C +    S G                     
Sbjct: 556 AAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLI 615

Query: 472 ------HVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRL 525
                  + L F  F++E      +D+L V+D      T++G + G E P  + S+   +
Sbjct: 616 ISEPGSRIHLIFNDFDVEPQ----FDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIV 671

Query: 526 WLKFVSDGSINKAGFAVNFFK-EVDECSRP------NRGG------------CEQRCLNT 566
            L+F SD S    GF + +     +EC  P       R G            C+   + T
Sbjct: 672 RLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKT 731

Query: 567 LGSYKCSC---DPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA 623
            GS   +C   D     +    RCEA CGG LT  +G I  PGWP  Y  + +C W + A
Sbjct: 732 QGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEA 791

Query: 624 PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRV 683
              + I + FD F+TE N    YD +EVR G  + S L G++ G++ P+ + S  N M +
Sbjct: 792 KPGHSIKITFDRFQTEVN----YDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYL 847

Query: 684 EFKSDNTVSKKGFKAHFFSV 703
            F +DN+ S  GF  H+ SV
Sbjct: 848 LFTTDNSRSSIGFLIHYESV 867



 Score =  147 bits (370), Expect = 5e-35
 Identities = 101/293 (34%), Positives = 142/293 (48%), Gaps = 36/293 (12%)

Query: 433  AICGGDVKK-DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            A CGG +     G I SP YP  Y  +  C W I+   G  + L F  F+ E     A+D
Sbjct: 1276 AECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEM----AHD 1331

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE- 550
             L+V DG  +S  L+  + G   P+DI ST + L L+F SD  I+K+GF++ F   +   
Sbjct: 1332 ILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAAT 1391

Query: 551  CSRPN------RGGCEQRCLNTLGSYKCSCDPGYELA-----------------PDKRRC 587
            C+ P       R G  +   +T+      CDPGY+L                  PD   C
Sbjct: 1392 CNDPGMPQNGTRYGDSREAGDTV---TFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             AACGG LT   G I SP +P+ YPP K C W++     + I+L F  F  E +    YD
Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YD 1504

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            F+ +  G  ++S L G + GS+ PE I S  N++ + F+SD +V   GF   F
Sbjct: 1505 FLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF 1557



 Score =  141 bits (356), Expect = 2e-33
 Identities = 94/286 (32%), Positives = 147/286 (51%), Gaps = 34/286 (11%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            C G+  +  G I SP YP+ Y  +  CIW+I V+EG  + +   SF  E++    +D LE
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD--ECS 552
            + DG   ++  +G + G   P  + STS++L+L F SD S+  AGF + + K V    C 
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEY-KTVGLAACQ 1917

Query: 553  RPNRGGC-----EQRCLNTLGSYKCSCDPGYELA--------PDKRR--------CEAAC 591
             P          ++  +N + S++C  +PGY L         P   R        C A C
Sbjct: 1918 EPALPSNSIKIGDRYMVNDVLSFQC--EPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975

Query: 592  GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
            GG L+ L G I SPG+P  YP N +C W++  P  Y   +QF  F TE N    +DF+E+
Sbjct: 1976 GGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLEI 2031

Query: 652  RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
            ++G    S + G+F G++ P  + S  +   + F SD++ +++GFK
Sbjct: 2032 QNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFK 2077



 Score =  139 bits (350), Expect = 1e-32
 Identities = 91/294 (30%), Positives = 145/294 (49%), Gaps = 40/294 (13%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG++    G I SPNYP  Y P K C WR++V+  F + L F+SF +E     +YD+
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEP----SYDF 1505

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
            L + +G   +S LIG Y G + P+ I+S+ + L+L F SD S+  +GFA+ F ++  E C
Sbjct: 1506 LHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREAC 1565

Query: 552  SRP------NRGGCEQRCLNTLGSYKCSCDPGYELAPDKR------------------RC 587
              P       R G + +  +T+ +Y+  CD GY++                        C
Sbjct: 1566 FDPGNIMNGTRVGTDFKLGSTI-TYQ--CDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             A CGG  T   G + SP +P  Y   + C++ +  P ++ +  QF +F+T  ND+    
Sbjct: 1623 NAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDL---- 1678

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700
              E+  G  A ++L     GS   E +  +  N + + F + +  S +GF  HF
Sbjct: 1679 -AELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGF--HF 1729



 Score =  125 bits (314), Expect = 2e-28
 Identities = 88/292 (30%), Positives = 135/292 (46%), Gaps = 32/292 (10%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            EA CGG +    G I  P +P  Y+ S  C W I+   G  + +TF  F+ E +    YD
Sbjct: 756  EAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVN----YD 811

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EV 548
             LEVRDG + SS LIG Y G + P  + ST + ++L F +D S +  GF +++     E 
Sbjct: 812  TLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLES 871

Query: 549  DECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAAC 591
            D C  P     G           +   SCDPGY L+ D+                C+A C
Sbjct: 872  DSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALC 931

Query: 592  GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
            GG++   +G++ SPG+P  YP + NC W +       + + F  F  E +    +D++ +
Sbjct: 932  GGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLLI 987

Query: 652  RSGLTADSKLHGKFCGSEKPEVI-TSQYNNM--RVEFKSDNTVSKKGFKAHF 700
                 + S+   +  GS  P  I    + N   ++ F SD ++S +GF   F
Sbjct: 988  TED-GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038



 Score =  123 bits (308), Expect = 8e-28
 Identities = 118/467 (25%), Positives = 186/467 (39%), Gaps = 101/467 (21%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG TL    G   SP +P  Y  ++ C WRIS+  G    + F +     +    +D++E
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLE 2030

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----C-- 435
            +++G +  +P+ G+F G+ LP  ++ST     + F S  +   +GF   Y+A     C  
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPD 2090

Query: 436  ------GGDVKKDYGHIQSP--------------------------NYP----------- 452
                  G  +  DY   QS                           NYP           
Sbjct: 2091 PPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYN 2150

Query: 453  --------------DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG 498
                          D+Y   K CIW I V  G  V + F   + E       DY+ V DG
Sbjct: 2151 VTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE----AVNDYIAVWDG 2206

Query: 499  HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSRPNRG 557
              ++S  +G + G    +   S+++++ LKF SD S N   F +NF   ++ +C  P   
Sbjct: 2207 PDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS-NGGFFVLNFHAFQLKKCQPPPAV 2265

Query: 558  GCEQRCLN----TLGSY-KCSCDPGYELA----------------PDKRRCEAAC--GGF 594
               +         +G + K  C PGY L                      CEA C     
Sbjct: 2266 PQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCPANEV 2325

Query: 595  LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
             T  +G I SPG+P  Y  ++ C W +     Y I++  D F++E     ++D +EV  G
Sbjct: 2326 RTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK----QFDALEVFDG 2381

Query: 655  LTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHF 700
             +  S L     G+   +   TS+ N + + + +D+  SKKGFK  +
Sbjct: 2382 SSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRY 2428



 Score =  122 bits (307), Expect = 1e-27
 Identities = 83/276 (30%), Positives = 127/276 (46%), Gaps = 28/276 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG +    G I SP +P  Y  +  C WRI +  G+   + F +F  E +    +D+
Sbjct: 1973 ATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDF 2028

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
            LE+++G   +S +IG++ G + P  + ST+    + F SD S N+ GF + +   E+  C
Sbjct: 2029 LEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088

Query: 552  SRP---NRGGCEQRCLNTLGSYKCSCDPGYELAPDK----------------RRCEAACG 592
              P     G       +   S    C PGY L                     RC+A CG
Sbjct: 2089 PDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCG 2148

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
              +T  NG+I SPG+P EYP  K+CIW +  P  + + + F   +TE  +    D++ V 
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIAVW 2204

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSD 688
             G   +S   G F G+   E   S  N + ++F SD
Sbjct: 2205 DGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD 2240



 Score =  118 bits (295), Expect = 3e-26
 Identities = 93/290 (32%), Positives = 127/290 (43%), Gaps = 36/290 (12%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CGG V+   G I+SP +P  Y     C W I   E   + L+F +F +E      +D L 
Sbjct: 32  CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF-AVNFFKEVDECSR 553
           V DG  +   L  R  G++ P  I ST S L L F +D +++  GF A+        C  
Sbjct: 88  VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147

Query: 554 PN---RGGCEQRCLNTLGSYKCSCDPGYEL----------APDKR----------RCEAA 590
           P    +G       N     + SC PGY L          +P             R E A
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207

Query: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
           CGG L   + SI+SP +P EY  N +C W ++A     I+L F  F+ E      YDF+E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLE 263

Query: 651 VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           + SG  A S       G   P  + S  N +R+ F SD+   +KGF A F
Sbjct: 264 I-SGTEAPSIW---LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQF 309



 Score =  103 bits (256), Expect = 8e-22
 Identities = 99/381 (25%), Positives = 156/381 (40%), Gaps = 48/381 (12%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG      G + SPNYP +Y   ++C++ I V + F V   F  F+     +   D 
Sbjct: 1624 APCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQ-----TALNDL 1678

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
             E+ DG    + L+    G    + +  +TS+++ L+F +    +  GF    ++ V   
Sbjct: 1679 AELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHF-VYQAVPRT 1737

Query: 552  SRPNRGGC-EQRCLNTLGS-------YKCSCDPGYELAPDKR------------------ 585
            S        E R    +GS        +  C+PGY L                       
Sbjct: 1738 SDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIP 1797

Query: 586  RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
             C   C G  T+  G+I SPG+P+ Y  N NCIW+++      I +Q   F TE N    
Sbjct: 1798 SCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN---- 1853

Query: 646  YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
            +D +E+  G    +   G F G+  P ++ S  N + + F+SD +V+  GF   + +V  
Sbjct: 1854 WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV-G 1912

Query: 706  GAGDRHSHLSGLELLLCPHALVDTVPA----PPSALHGDTHAH----THTHVHTHCPIAQ 757
             A  +   L    + +    +V+ V +    P   L G +H      T    +   P+  
Sbjct: 1913 LAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI 1972

Query: 758  ETCRG--PPLGASRLSPQGPG 776
             TC G    LG   LSP  PG
Sbjct: 1973 ATCGGTLSTLGGVILSPGFPG 1993



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 81/295 (27%), Positives = 132/295 (44%), Gaps = 34/295 (11%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            +A+CGG ++   G + SP +PD Y  S  C W I+VS G  V + F +F +E     ++D
Sbjct: 928  DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE----SSHD 983

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
            YL + +  S S   + R  G   P  IK+    +    L+F+SD SI+  GF + F + +
Sbjct: 984  YLLITEDGSFSEP-VARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYD 1042

Query: 548  VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
            ++ C  P      +R     G   S   SC  GY L    +                RC 
Sbjct: 1043 LEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102

Query: 589  AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
            A CG  +    G++ SP +P  Y  N  CI+++       I L+   F+    D  K   
Sbjct: 1103 AECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK--- 1159

Query: 649  VEVRSGLTADSKLHGKFCGSE-KPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
              V  G  + S+  G F  +E    ++ S  N++ +EF ++ + + +GF+  + S
Sbjct: 1160 --VYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTS 1212



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 87/348 (25%), Positives = 140/348 (40%), Gaps = 71/348 (20%)

Query: 418 SSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF 477
           + ++W     F   E  CGG ++     I SP++P +Y  +  C W I    G  + L F
Sbjct: 191 NGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVF 250

Query: 478 QSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINK 537
             F++E      YD+LE+    + S  L     G   P  + S+ + L L F SD +  +
Sbjct: 251 TDFQLEE----GYDFLEISGTEAPSIWL----TGMNLPSPVISSKNWLRLHFTSDSNHRR 302

Query: 538 AGFAVNF--FKEVDECSR-----PNRGGCEQRCLNTLG---------------------- 568
            GF   F   K ++  SR     P++ G  +  + + G                      
Sbjct: 303 KGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAG 362

Query: 569 --------SYKCSCDPGYELAPDKR------------------RCEA-ACGGFLTKLNGS 601
                   + + SC+  Y L   K                    C A  CG  L   +G 
Sbjct: 363 SDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGV 422

Query: 602 ITSPGWPKEYPPNKNCIWQLVAPTQYR-ISLQFDFFETEGNDVCKYDFVEV-RSGLTADS 659
           ITSP +P +Y  N +C+W +      + I L F+ FE E      YD + V  +G   D+
Sbjct: 423 ITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDTLTVGDAGKVGDT 478

Query: 660 K-LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706
           + +     GS  P++I S  N M +  +SD+++   GFKA +  + +G
Sbjct: 479 RSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG 526



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 40/110 (36%), Positives = 57/110 (51%), Gaps = 5/110 (4%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            ACG  L    G   SP YP  Y     C WR+ V P   I L F S ++  S    YD++
Sbjct: 1451 ACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YDFL 1506

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
             + +G    +PL G + GS+ PE I S+ + L++ FRS ++ VG   FA+
Sbjct: 1507 HIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDAS-VGLSGFAI 1555



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 39/112 (34%), Positives = 58/112 (51%), Gaps = 8/112 (7%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG TL+ ++ + SSP +P+ Y  +  C W I   PG+ I L FT   L       YD++
Sbjct: 207 ACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFL 262

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
           E+      +AP      G  LP P++S+ + L + F S SN   KGF A ++
Sbjct: 263 EISG---TEAPSIW-LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ 310



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 46/143 (32%), Positives = 67/143 (46%), Gaps = 10/143 (6%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  +Q   G   SP +P+GY  + +C W I      +I L+F +  L       +D + 
Sbjct: 32  CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----CG- 436
           V DG  ++  L+ R  G +LP  IVST S L + F +      +GF A+YE +    CG 
Sbjct: 88  VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147

Query: 437 -GDVKKDYGHIQSPNYPDDYRPS 458
            G++ K   H    N  D  R S
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYS 170



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 4/113 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            C        G   SP YP  Y  +++C+W+I VT G  I +   S    ++    +D +E
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
            + DG    AP  G F G+ +P  + ST ++L++ F+S  +    GF   Y+ +
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 53/169 (31%), Positives = 76/169 (44%), Gaps = 16/169 (9%)

Query: 269  IMHYARNTFSRGIFLDTIV-----PKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPA-C 322
            I +Y       G F DT+V     P Y ++G        T LS       + L  C A C
Sbjct: 1223 IPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNT----LTCLSGDRRVWDKPLPSCIAEC 1278

Query: 323  GETLQDST-GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            G  +  +T G   SP YP  Y  ++HC W I   PG+ I L+F   D   +    +D ++
Sbjct: 1279 GGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMA----HDILK 1334

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
            V DG      L   + GS LPE I ST + L ++F  S  ++ K  F++
Sbjct: 1335 VWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQF-DSDFFISKSGFSI 1382



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 7/114 (6%)

Query: 318  KCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCW 376
            +C A CG  +    G   SP +P+ Y     C+W I+V PG  + +NFT L         
Sbjct: 2142 RCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN--- 2198

Query: 377  YDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
             DY+ V DG  + +P  G F G+   E   S+ +++ ++F   S++   GFF +
Sbjct: 2199 -DYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFH--SDFSNGGFFVL 2249



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 7/131 (5%)

Query: 303  TRLSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII 361
            T L  G    +  L +C A CG +++ + G   SP +P+ Y  +  C+++I    G+ I 
Sbjct: 1085 TCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIH 1144

Query: 362  LNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIV-STDSRLWVEFRSSS 420
            L   S  L+       D ++V DG    +   G F  ++L   I+ ST + LW+EF ++ 
Sbjct: 1145 LRTRSFQLFEG-----DTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNG 1199

Query: 421  NWVGKGFFAVY 431
            +   +GF   Y
Sbjct: 1200 SDTDQGFQLTY 1210



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 6/114 (5%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG     S G   SP YP+ Y+A   C++ I+V P E ++  F     +++ L   D  E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITV-PKEFVV--FGQFAYFQTAL--NDLAE 1680

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
            + DG   +A L     GS   E + ++T +++ + F + S    +GF  VY+A+
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAV 1734



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L  C A CG  +Q  +G   SP +P+ Y   ++C W I V+ G+ + + F +  L  S  
Sbjct: 924  LPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS-- 981

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI 405
              +DY+ + +      P+  R  GS LP  I
Sbjct: 982  --HDYLLITEDGSFSEPV-ARLTGSVLPHTI 1009



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 6/117 (5%)

Query: 318  KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
            +CPA  E    S+G   SP YP  Y     C W I V P   I +    +D ++S    +
Sbjct: 2319 QCPA-NEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITI---FVDTFQSEK-QF 2373

Query: 378  DYVEVRDGFWRKAPLRGRFCGSKLPEP-IVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            D +EV DG   ++PL     G+   +    S  ++L++ + +      KGF   Y A
Sbjct: 2374 DALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score =  154 bits (390), Expect = 2e-37
 Identities = 96/288 (33%), Positives = 152/288 (52%), Gaps = 32/288 (11%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG++ +  G I SP +P+ Y  S  C+W+I V EG  + +   SF  E++    +D LE
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF----FKEVDE 550
            V DG   + T++G + G   P  + STS++L+L F SD S++ AGF + +         E
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPE 1911

Query: 551  CSRPNRG--GCEQRCLNTLGSYKCSCDPGYELA--------PDKRR--------CEAACG 592
             + P+ G    E+  +N + S++C  +PGY L         P   R        C A CG
Sbjct: 1912 PAVPSNGVKTGERYLVNDVVSFQC--EPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCG 1969

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G + ++ G I SPG+P  YP N +C W++  P  +   +QF  F TE N    +D++E+R
Sbjct: 1970 GTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIEIR 2025

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            +G    S++ G+F GSE P  + S  +   V F SD++ ++ GFK  +
Sbjct: 2026 NGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEY 2073



 Score =  147 bits (370), Expect = 5e-35
 Identities = 98/288 (34%), Positives = 135/288 (46%), Gaps = 34/288 (11%)

Query: 433  AICGGDVKKDY-GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            A CGG V+ +  G + SP YP  Y  +  CIW I+   G  +GL F  F+ E      +D
Sbjct: 1269 AECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHD 1324

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
             L + DG  ES  L+    G   P D+ ST + + L+F +D   +K GFA+ F   V   
Sbjct: 1325 VLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF--SVSTA 1382

Query: 552  SRPNRGGCEQRCLNTLGSYKCS------CDPGYELA-----------------PDKRRCE 588
            +  N  G  Q    +  S++        CDPGY L                  P    C 
Sbjct: 1383 TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCI 1442

Query: 589  AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
            A CGG LT  +G I SP +P+ YPP K C W++     Y I+L F+ F  E      YDF
Sbjct: 1443 APCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDF 1498

Query: 649  VEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
            + +  G  + S L G F GS+ P  I S  N++ + F+SD +VS  GF
Sbjct: 1499 LHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGF 1546



 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/294 (32%), Positives = 140/294 (47%), Gaps = 40/294 (13%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGGD+    G I SPNYP+ Y P K C W++ VS  + + L F  F +E      YD+
Sbjct: 1443 APCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP----GYDF 1498

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
            L + DG    S LIG + G + P  I+S+S+ L+L F SD S++ AGF +++ +   E C
Sbjct: 1499 LHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESC 1558

Query: 552  SRP------NRGGCEQRCLNTLGSYKCSCDPGYE----------LAPDKRR--------C 587
              P       R G + +  +++  Y   C  GYE          L PD +         C
Sbjct: 1559 FDPGSIKNGTRVGSDLKLGSSVTYY---CHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC 1615

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             A CGG     +G + SP +P+ Y   + C++ +  P  Y +  QF FF T  NDV    
Sbjct: 1616 TAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDV---- 1671

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700
             VEV  G +  S+L     GS   E +  +  N + ++F +      +GF  HF
Sbjct: 1672 -VEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGF--HF 1722



 Score =  136 bits (342), Expect = 9e-32
 Identities = 93/310 (30%), Positives = 145/310 (46%), Gaps = 34/310 (10%)

Query: 417 RSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLT 476
           + ++ W  K    V+   C  +     G + SPNYP+DY     C+W I       + L 
Sbjct: 562 QKNNQWSAKKPGCVFS--CFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLA 619

Query: 477 FQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSIN 536
           F   ++E      +D+L ++DG +  + ++G + G + P  I S+     L+F +D S  
Sbjct: 620 FNDIDVEPQ----FDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTG 675

Query: 537 KAGFAVNF--FKEVDECSRPN------RGG------------CEQRCLNTLGSYKCSC-- 574
           K GF + F  F+  +EC  P       R G            C++  L T GS   +C  
Sbjct: 676 KRGFNITFTTFRH-NECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVL 734

Query: 575 -DPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF 633
            +          RCEA CGG LT  +G+I SPGWP  Y    +C W + A   Y I + F
Sbjct: 735 KEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITF 794

Query: 634 DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSK 693
           D F+TE N    YD +EVR G T  + L G + G++ P+ + S  N + + F +D + S 
Sbjct: 795 DRFKTEVN----YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSD 850

Query: 694 KGFKAHFFSV 703
            GF+  + ++
Sbjct: 851 IGFQLRYETI 860



 Score =  125 bits (315), Expect = 1e-28
 Identities = 84/288 (29%), Positives = 141/288 (48%), Gaps = 29/288 (10%)

Query: 434 ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDY 492
           +C   ++   G I SPN+P  Y  +  C+W I  ++    + L F+ F++ER     YD 
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER----GYDT 459

Query: 493 LEVRDG--HSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVD 549
           L V DG    +  T++    G   PD I ST+ ++WL F +DGS +  GF  ++ + E  
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQG 519

Query: 550 ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
            C  P     G  E    +   + K  C P +EL   K                C  +C 
Sbjct: 520 SCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCF 579

Query: 593 GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
              T  +G + SP +P++Y  + +C+W ++A  + RI L F+  + E     ++DF+ ++
Sbjct: 580 FNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIK 635

Query: 653 SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            G TA++ + G F G++ P  ITS  +  R+EF++D++  K+GF   F
Sbjct: 636 DGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF 683



 Score =  125 bits (314), Expect = 2e-28
 Identities = 92/292 (31%), Positives = 137/292 (46%), Gaps = 32/292 (10%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            EA CGG +    G I SP +P  Y+ +  C W I+   G+ + +TF  F+ E +    YD
Sbjct: 749  EAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVN----YD 804

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EV 548
             LEVRDG + S+ LIG Y G + P  + STS+ L+L F +D S +  GF + +     + 
Sbjct: 805  TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864

Query: 549  DECSRPNRGGCEQRCLN-----TLGSYKCS------------CDPGYELAPDKRRCEAAC 591
            D C  P      QR  N      L ++ C             C+P ++ +     CEA C
Sbjct: 865  DHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALC 924

Query: 592  GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
            GGF+   +G+I SPG+P  YP N NC W +       +   F  F  E      +D++ +
Sbjct: 925  GGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLLI 980

Query: 652  RSGLTADSKLHGKFCGSEKPEVITS-QYNNM--RVEFKSDNTVSKKGFKAHF 700
                +    L  +  GS  P  I++  Y N   +V F SD ++S +GF   F
Sbjct: 981  TENGSFTQPLR-QLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITF 1031



 Score =  122 bits (306), Expect = 1e-27
 Identities = 87/291 (29%), Positives = 133/291 (45%), Gaps = 32/291 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CG  V    G + SPN+P +Y  +  CI+ IQ   G  + L  ++FE+   D      
Sbjct: 1096 AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGD-----V 1150

Query: 493  LEVRDGHSESSTLIGRYCGYEKPD-DIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
            L+V DG++ S+ L+G +   E     + STSS LWL F++D      GF ++F   E+ +
Sbjct: 1151 LKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIK 1210

Query: 551  CSRPNRGGCEQRCLN----TLGSYKCSCDPGYELAPDKR----------------RCEAA 590
            C  P       +  +       S   SCDPGY L   +                  C A 
Sbjct: 1211 CEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE 1270

Query: 591  CGGFLT-KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
            CGG +  +++G + SPG+P  Y  N NCIW + A     I L F  F+TE      +D +
Sbjct: 1271 CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHDVL 1326

Query: 650  EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
             +  G      L  +  G   P+ + S +N++ ++F +D   SK+GF   F
Sbjct: 1327 RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF 1377



 Score =  117 bits (293), Expect = 4e-26
 Identities = 85/318 (26%), Positives = 133/318 (41%), Gaps = 70/318 (22%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG V++  G I SP +P +Y  +  C W+I +  GF   + F +F  E +    +DY
Sbjct: 1966 AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDY 2021

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK------ 546
            +E+R+G  E+S ++GR+ G E P  + STS    + F SD S N+ GF + +        
Sbjct: 2022 IEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQ 2081

Query: 547  --------EVDECSRPNR-------------GGCE----QRC---------------LNT 566
                    ++ E  R N               GCE    Q C                N 
Sbjct: 2082 ISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNV 2141

Query: 567  LGSYKCSCDPGYELAPDK----------------RRCEAACGGFLTKLNGSITSPGWPKE 610
              S    C PGY+L                     +CE  CGG +T  NG++ SPG+P  
Sbjct: 2142 GQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSP 2201

Query: 611  YPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEK 670
            Y  +++C+W +  P  + + L     +TE +     DF+ +  G    +   G F  S  
Sbjct: 2202 YSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDGPQQTAPRLGVFTRSMA 2257

Query: 671  PEVITSQYNNMRVEFKSD 688
             + + S  N + ++F  D
Sbjct: 2258 KKTVQSSSNQVLLKFHRD 2275



 Score =  113 bits (283), Expect = 6e-25
 Identities = 87/301 (28%), Positives = 132/301 (43%), Gaps = 37/301 (12%)

Query: 430  VYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCA 489
            V  A CGG      G + SPNYP +Y   ++C++ + V + + V   F  F      +  
Sbjct: 1614 VCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFH-----TAL 1668

Query: 490  YDYLEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEV 548
             D +EV DGHS+ S L+    G    + +  +TS+++ +KF + G     GF    ++ V
Sbjct: 1669 NDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHF-VYQAV 1727

Query: 549  DECSRPNRGGC-EQRCLNTLGS-------YKCSCDPGYELAPDKR--------------- 585
               S        E R    LGS        +  C+ GY L                    
Sbjct: 1728 PRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNV 1787

Query: 586  ---RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642
                C   CGG LT+  G+I SPG+P+ Y  + NC+W++V P    I +Q   F TE N 
Sbjct: 1788 SAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN- 1846

Query: 643  VCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
               +D +EV  G      + G F G+  P ++ S  N + + F SD +VS  GF   + +
Sbjct: 1847 ---WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKT 1903

Query: 703  V 703
            V
Sbjct: 1904 V 1904



 Score =  110 bits (275), Expect = 5e-24
 Identities = 88/283 (31%), Positives = 125/283 (44%), Gaps = 40/283 (14%)

Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS 503
           G ++SP +P  Y     C W I   E   + L FQSF +E      +D L V DG  +  
Sbjct: 35  GTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FDVLSVFDGPPQPE 90

Query: 504 TLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEV---DECSRPNR--GG 558
            L  R  G++ P  I S ++ L L+ +SD +++  GF   +  EV     C  P R   G
Sbjct: 91  NLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATY--EVLPSHTCGNPGRLPNG 148

Query: 559 CEQRCLNTLGS---YKCS------------CDPGYELAPD------KRRCEAACGGFLTK 597
            +Q     LG    Y C+            C  G E +          R + ACGG L  
Sbjct: 149 IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRG 208

Query: 598 LNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTA 657
            +G I+SP +P EY  N +C W ++A     I+L F  F+ E      YDF+EV    T 
Sbjct: 209 QSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLEVTG--TE 262

Query: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            S L   F G+  P  + S  N +R+ F SD    ++GF A +
Sbjct: 263 GSSLW--FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQY 303



 Score =  108 bits (270), Expect = 2e-23
 Identities = 123/485 (25%), Positives = 190/485 (39%), Gaps = 100/485 (20%)

Query: 305  LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
            L +G +     + +C A CG  L   +G   SP +P  Y   + C W I   PG  I + 
Sbjct: 734  LKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKIT 793

Query: 364  FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            F   D +++ +  YD +EVRDG    APL G + G+++P+ ++ST + L++ F +  +  
Sbjct: 794  F---DRFKTEVN-YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHS 849

Query: 424  GKGFFAVYEAIC------------------GGD--------VKKDYGHIQSPNYPDDYRP 457
              GF   YE I                   G D           D G+  S   P +  P
Sbjct: 850  DIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEP 909

Query: 458  S-----------KVCIWRIQVSEGFHVGLTFQSFEIER---------------------- 484
            +            +C   IQ S G  +   F  F                          
Sbjct: 910  NFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTF 969

Query: 485  HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFA 541
            H    +DYL + +  S +  L  +  G   P  I +    +    ++F+SD S++  GF 
Sbjct: 970  HLESGHDYLLITENGSFTQPL-RQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFN 1028

Query: 542  VNFFK-EVDECSRPN------RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------- 585
            + F + +++ C  P       R G +    +TL     SC PGY L    R         
Sbjct: 1029 ITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTL---TFSCFPGYRLEGTARITCLGGRRR 1085

Query: 586  -------RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFET 638
                   RC A CG  +T   G++ SP +P  Y  N  CI+ +       I L+   FE 
Sbjct: 1086 LWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFEL 1145

Query: 639  EGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFK 697
               DV K     V  G    ++L G F  SE   V + S  +++ ++F +D   + KGF+
Sbjct: 1146 SEGDVLK-----VYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFE 1200

Query: 698  AHFFS 702
             HF S
Sbjct: 1201 LHFSS 1205



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 126/510 (24%), Positives = 193/510 (37%), Gaps = 139/510 (27%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDL------------ 369
           C   L    G   SP +P GY  + +C W I+     +I L F S  L            
Sbjct: 26  CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85

Query: 370 ------YRSRLCWY-------------------DYVEVRDGFWRKAP-LRGRFCGS--KL 401
                  R+RL  +                   DY     GF      L    CG+  +L
Sbjct: 86  PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRL 145

Query: 402 PEPIVSTDS-RLWVEFRSSSNWVGKGFFAVYEAI-------------------------C 435
           P  I    +  L  + R S N    GFF    A+                         C
Sbjct: 146 PNGIQQGSTFNLGDKVRYSCNL---GFFLEGHAVLTCHAGSENSATWDFPLPSCRADDAC 202

Query: 436 GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
           GG ++   G I SP++P +Y  +  C W I    G  + L F  F++E      YD+LEV
Sbjct: 203 GGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED----GYDFLEV 258

Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSR 553
               +E S+L   + G   P  + S+ + L L F SDG+  + GF+  +   K+++  SR
Sbjct: 259 TG--TEGSSL--WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSR 314

Query: 554 -----PNRGGCEQRCLNT----------------------LG-------SYKCSCDPGYE 579
                P++   ++  + T                      LG       S + +C+ GY+
Sbjct: 315 GVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYD 374

Query: 580 LAPDKR------------------RCEA-ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQ 620
           L   KR                   C A  C   L   +G ITSP +P +Y  N +C+W 
Sbjct: 375 LQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWI 434

Query: 621 LVAPTQYR-ISLQFDFFETEGNDVCKYDFVEV-RSGLTADSK-LHGKFCGSEKPEVITSQ 677
           + A    + I L F+ F+ E      YD + V   G   D K +     G+  P++I S 
Sbjct: 435 ITALNPSKVIKLAFEEFDLERG----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVST 490

Query: 678 YNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
            + M + F++D + S  GFKA +  + +G+
Sbjct: 491 NHQMWLLFQTDGSGSSLGFKASYEEIEQGS 520



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 75/294 (25%), Positives = 125/294 (42%), Gaps = 34/294 (11%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            E  CGG++    G + SP +P  Y  S+ C+W I V  G  V L     + E     + D
Sbjct: 2179 EVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP----SGD 2234

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
            ++ + DG  +++  +G +        ++S+S+++ LKF  D +     FA+ F    + +
Sbjct: 2235 FITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGI-FAIAFSAYPLTK 2293

Query: 551  CSRPN-----RGGCEQRCLNTLGSYKCSCDPGYELAPDK----------------RRCEA 589
            C  P          E    N     +  C PG+ L  ++                  CE 
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353

Query: 590  AC--GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             C     LT   G I S  +P  YP  + C W +     Y ISL  ++F +E     +YD
Sbjct: 2354 HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYD 2409

Query: 648  FVEVRSGLTADSKLHGKFCGS-EKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
              E+  G +  S L     G+   P ++TS  N++ + + SD+  ++KGFK  +
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRY 2463



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)

Query: 272 YARNTFSRGIFLDTIVPKYEVNGVKPPIGQRT-RLSKGDIAQARKLYKCPACGETLQDST 330
           Y R   SR    DT+  K+E       +GQ+     K +   A+K     +C       +
Sbjct: 529 YGRREGSRFHHGDTL--KFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPS 586

Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
           G   SP YP  Y  H+HCVW I   P  +I L F  +D+       +D++ ++DG   +A
Sbjct: 587 GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFLVIKDGATAEA 642

Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGF 427
           P+ G F G++LP  I S+     +EF++  +   +GF
Sbjct: 643 PVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGF 679



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 34/111 (30%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG T+++  G   SP +P  Y ++M C W+I++  G    + F +     +    +DY+E
Sbjct: 1968 CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIE 2023

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
            +R+G +  + + GRF GS+LP  ++ST     V F S  +    GF   Y+
Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 38/110 (34%), Positives = 55/110 (50%), Gaps = 4/110 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L   +G   SP YP  Y     C W+++V+P   I L F   +L       YD++ 
Sbjct: 1445 CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDFLH 1500

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
            + DG    +PL G F GS+LP  I S+ + L++ FRS ++    GF   Y
Sbjct: 1501 IYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY 1550



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 38/116 (32%), Positives = 54/116 (46%), Gaps = 16/116 (13%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG TL+  +G  SSP +P+ Y  +  C W I    G+ I L F    L       YD++
Sbjct: 201 ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFL 256

Query: 381 EVR----DGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
           EV        W        F G+ LP P++S+ + L + F S  N   +GF A Y+
Sbjct: 257 EVTGTEGSSLW--------FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQ 304



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 43/145 (29%), Positives = 68/145 (46%), Gaps = 11/145 (7%)

Query: 314 RKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRS 372
           R + +   C   L+  +G  +SP +P  Y  + HCVW I ++ P + I L F   DL R 
Sbjct: 397 RPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERG 456

Query: 373 RLCWYDYVEVRDG--FWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
               YD + V DG     +  +     G+ +P+ IVST+ ++W+ F++  +    GF A 
Sbjct: 457 ----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKAS 512

Query: 431 YEAI----CGGDVKKDYGHIQSPNY 451
           YE I    CG      YG  +   +
Sbjct: 513 YEEIEQGSCGDPGIPAYGRREGSRF 537



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 4/113 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L +  G   SP +P  Y   ++CVW+I V  G  I +   S    ++    +D +E
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
            V DG      + G F G+ +P  + ST ++L++ F S  +    GF   Y+ +
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 38/124 (30%), Positives = 61/124 (49%), Gaps = 10/124 (8%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG ++  + G   SP +P  Y+ +  C++ I   PG+ I L   + +L     
Sbjct: 1091 LPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-- 1148

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSK-LPEPIVSTDSRLWVEFRSSSNWVGKGF---FAV 430
               D ++V DG    A L G F  S+ +   + ST S LW++F + +    KGF   F+ 
Sbjct: 1149 ---DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205

Query: 431  YEAI 434
            +E I
Sbjct: 1206 FELI 1209



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 7/116 (6%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L KC   CG  +  S G   SP +P+ YS+   CVW I+V  G  + LN + L    S  
Sbjct: 2175 LPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG- 2233

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
               D++ + DG  + AP  G F  S   + + S+ +++ ++F   +     G FA+
Sbjct: 2234 ---DFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDA--ATGGIFAI 2284



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 6/116 (5%)

Query: 319  CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
            CP   E L DSTG   S  YP  Y     C W + V P   I L   +++ + S    YD
Sbjct: 2355 CPT-NELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISL---TVEYFLSEK-QYD 2409

Query: 379  YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
              E+ DG   ++PL     G+   P  + S+ + +++ + S   +  KGF   Y A
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 7/143 (4%)

Query: 314  RKLYKCPA-CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
            R L  C A CG T++ + +G   SP YP  Y  +++C+W I    G  I L+F   D   
Sbjct: 1262 RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE 1321

Query: 372  SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
                 +D + + DG      L     G  LP+ + ST + + ++F S+  +  K  FA+ 
Sbjct: 1322 V----HDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQF-STDFFTSKQGFAIQ 1376

Query: 432  EAICGGDVKKDYGHIQSPNYPDD 454
             ++       D G  Q+ +   D
Sbjct: 1377 FSVSTATSCNDPGIPQNGSRSGD 1399



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 31/114 (27%), Positives = 56/114 (49%), Gaps = 6/114 (5%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG     S G   SP YP  Y++   C++ ++V P + ++  F     + + L   D VE
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTV-PKDYVV--FGQFAFFHTAL--NDVVE 1673

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
            V DG  + + L     GS   E + ++T +++ ++F +      +GF  VY+A+
Sbjct: 1674 VHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAV 1727


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score =  154 bits (388), Expect = 4e-37
 Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)

Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
           ++ CGG +    G   SPNYPD Y P+  C+W IQV+    + L  ++  IE   SC +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
            LE+     E    + R CG   P  + + +S L + FVSD S+   GF   +     + 
Sbjct: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252

Query: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602
             P RG C   E RC   +     S   G+    D   +  C A    CGG LT L G+ 
Sbjct: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312

Query: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661
           ++P + ++YP    C W +  P  + I LQF  F  E  D CK+D+VEV  +  +    L
Sbjct: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372

Query: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            G+FCG+E P  + S ++ + V F++D+ +S  GF A + +
Sbjct: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413



 Score =  117 bits (293), Expect = 4e-26
 Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  L    G FSSP YP+ Y  + HCVW I V     I L   +L +     C +D +E
Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434
           +      + PL  R CG ++P P ++T+ S L V F S S+  G GF A Y+A+      
Sbjct: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259

Query: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453
                                                    CGG++    G   +P+Y  
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319

Query: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512
            Y    +C W I V  G  + L F +F +E  D C +DY+EV +  S  + +L+GR+CG 
Sbjct: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379

Query: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560
           E P  + S+   L + F +D  I+  GF+  +  F   +    P+   C+
Sbjct: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)

Query: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
           K   CG  L    G FS+P Y   Y   + C W ISV  G  I L F +  L     C +
Sbjct: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356

Query: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
           DYVEV +     A  L GRFCG++ P  +VS+   L V FR+       GF A Y A
Sbjct: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 3/121 (2%)

Query: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
           ++ CGG L+   G  +SP +P  YPPN +C+W +   T + I L+ +    E    C +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
            +E+            + CG   P  + +  +++ V F SD++V   GF A + ++  G 
Sbjct: 201 RLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257

Query: 708 G 708
           G
Sbjct: 258 G 258


>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
          Length = 415

 Score =  152 bits (385), Expect = 9e-37
 Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 37/268 (13%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CGG +  + G I S  +P  Y P+  C W+I V EG  V L F+  ++E  + C YD+++
Sbjct: 33  CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           V +GH+     IGR+CG  +P  + S+ +++ ++ +SD +    GF   F       + P
Sbjct: 93  VYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146

Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
           N  G                             +  CGG L + +GS  +P WP ++YP 
Sbjct: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKLHGKFCGSEKPE 672
              C+W +VAP    I L+F+ F+ E ++ C+YD+V V   G   D++  GK+CG   P 
Sbjct: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237

Query: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            I S+ N + ++F SD +++  GF  H+
Sbjct: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265



 Score =  148 bits (373), Expect = 2e-35
 Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 31/284 (10%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  L   +G   S  +P  Y  +  C W+I+V  G+ ++LNF  +DL    LC YD+V+
Sbjct: 33  CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
           V +G      + GRFCG+  P  +VS+ +++ V+  S +N  G GF A++ A        
Sbjct: 93  VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151

Query: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
             CGG + +  G  ++PN+PD DY     C+W I   +   + L F+ F++ER + C YD
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211

Query: 492 YLEV-RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE--- 547
           Y+ V   G    +  IG+YCG   P  I S  + L ++F+SD S+   GF  ++      
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271

Query: 548 --------------VDECSRPNRGGCEQRC--LNTLGSYKCSCD 575
                         V    +P    C+Q+C    TL    CS D
Sbjct: 272 LPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSD 315


>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
          Length = 909

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
          Length = 901

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
          Length = 931

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
          Length = 555

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
          Length = 906

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
          Length = 926

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85

Query: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204

Query: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264

Query: 545 F 545
           +
Sbjct: 265 Y 265



 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146

Query: 708 GD 709
            D
Sbjct: 147 ED 148


>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  147 bits (372), Expect = 3e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83

Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143

Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203

Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259

Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73

Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129

Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
           GF A Y A+   + K+        D+                                  
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189

Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249

Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305

Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
            P  G  E  Q           SCD GY++  D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82

Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  147 bits (372), Expect = 3e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83

Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143

Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203

Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259

Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73

Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129

Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
           GF A Y A+   + K+        D+                                  
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189

Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249

Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305

Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
            P  G  E  Q           SCD GY++  D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82

Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  147 bits (372), Expect = 3e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83

Query: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143

Query: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203

Query: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259

Query: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73

Query: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129

Query: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443
           GF A Y A+   + K+        D+                                  
Sbjct: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189

Query: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249

Query: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305

Query: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583
            P  G  E  Q           SCD GY++  D
Sbjct: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82

Query: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  145 bits (367), Expect = 1e-34
 Identities = 102/280 (36%), Positives = 137/280 (48%), Gaps = 28/280 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG +    G I SP +P +Y  S  C W I +  GF V L F +F  E      +DY
Sbjct: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
            LEVR G SE+ST+IGR  G + P  + ST+    L F SD S NK GF + +   ++  C
Sbjct: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184

Query: 552  S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
               RP R G       T+G +    C PGY L  +                  RCEA CG
Sbjct: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +T +NG+I SPG+P EYP  ++C W +  P    I + F   +TE      YDF+ V 
Sbjct: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVS 692
             G   +S   G+F G+   E + S  N + ++F SD T S
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2340



 Score =  144 bits (362), Expect = 4e-34
 Identities = 105/310 (33%), Positives = 146/310 (47%), Gaps = 31/310 (10%)

Query: 433  AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            A CGG  K +  G I SP YP  Y  +  C+W I+V  G  V L F +F+ E     ++D
Sbjct: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
             L V DG  E+  L+    G   P+ I ST + + ++F +D  I+K+GFA+ F   V   
Sbjct: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487

Query: 552  SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
             R    P  G           +    CDPGYEL  ++R                  C A 
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547

Query: 591  CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
            CGG LT  +G I SP +P  YP +++C W +     Y ISL F  F  E N    YDF+ 
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603

Query: 651  VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL-EGAGD 709
            +  G  ++S L G F  S+ PE I S  N M + F+SD +VS  GF   + + L E   D
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1663

Query: 710  RHSHLSGLEL 719
              + ++G  L
Sbjct: 1664 PGNIMNGTRL 1673



 Score =  138 bits (347), Expect = 2e-32
 Identities = 94/292 (32%), Positives = 141/292 (48%), Gaps = 32/292 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           C  +     G + SP+YP+ Y  +  CIW I    G  + L+F  F++E      +D+L 
Sbjct: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 736

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
           V+DG S  S ++G + G E P  + S S  L L+F +D S++  GF +  N F   +EC 
Sbjct: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 795

Query: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
            P       R G            CE+  + T G+   +C   D     +    +C A C
Sbjct: 796 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 855

Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
           GG  +  +G I SPGWP  Y  + NC W + A   + I + F+ F+TE N    YD +EV
Sbjct: 856 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 911

Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
             G    S L G + G++ P+ + S  N + + F +DN+ S  GFK H+ SV
Sbjct: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 963



 Score =  135 bits (341), Expect = 1e-31
 Identities = 90/284 (31%), Positives = 140/284 (49%), Gaps = 32/284 (11%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + K  G I SP YP+ Y  +  C+W+I V EG  + +   SF  E +    +D L+
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
              DG   ++  +G Y G   P  + STS+ L+L F SD S++ AGF + +    +D C  
Sbjct: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2014

Query: 554  PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
            P          ++  +  + S++C  D GY L           P +R       C A CG
Sbjct: 2015 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2072

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G ++  +G I SPG+P  YP + +C W +  P  + + LQF  F TE      +D++EVR
Sbjct: 2073 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2128

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
            SG +  S + G+  G + P  + S  +   + F SD + +K+GF
Sbjct: 2129 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF 2172



 Score =  135 bits (340), Expect = 2e-31
 Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 40/294 (13%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG++    G I SPN+P  Y  S+ C W I V+  + + L F SF IE +    YD+
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
            L + DG   +S LIG +   + P+ I+S+S+ + L F SDGS++  GF + +  ++ E C
Sbjct: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661

Query: 552  SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
              P       R G + +  +T+  Y   CD GY L               P   R    C
Sbjct: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             A CG   T   G++ SP +PK Y    NC++ +  P ++ +  QF FF+T  +DV    
Sbjct: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1774

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700
             VEV  G T  S L     GS   E +  S  N + + F S   ++ KGF  HF
Sbjct: 1775 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HF 1825



 Score =  124 bits (311), Expect = 4e-28
 Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
           CG +++   G   SPN+P  Y  +  C+W I  V+    + + F+ F++E      YD L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563

Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
            + DG    +  T++    G   PD I S SS++WL   +D S+   GF VN+ + E + 
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623

Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
           C  P     G  E    +     +  C  G+EL  +K                C   C  
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683

Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
             T   G++ SP +P+ Y  N NCIW +++    RI L F+ F+ E     ++DF+ V+ 
Sbjct: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 739

Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
           G + +S + G F G+E P  +TS  + +R+EF++D+++S +GF
Sbjct: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 36/314 (11%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CG       G + SPNYP +Y     C++ I V + F V   F  F+   HD      
Sbjct: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
            +EV DG ++ S+L+    G    + +  S+ +++ ++F S G I   GF   +       
Sbjct: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834

Query: 552  SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
            S       E R    +G       S    C+PGY          E  P+           
Sbjct: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894

Query: 587  CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
            C   CGG LTK  G+I SPG+P+ Y  N NC+W++  P    I +Q   F TE N    +
Sbjct: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV-LE 705
            D ++   G   ++   G + G+  P ++ S  NN+ + F+SD +VS  GF   + ++ L+
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010

Query: 706  GAGDRHSHLSGLEL 719
               +  +  SG+++
Sbjct: 2011 SCPEPQTPSSGIKI 2024



 Score =  115 bits (287), Expect = 2e-25
 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CGG +K   G I+SP +P  Y     C W I   E   + + FQSF +E      YDYL 
Sbjct: 25  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           + DGH   +    R  G+  P  + ST S   L+  SD +++  GF V +++E+   S  
Sbjct: 81  LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139

Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
           N G   +  L     +     + SC  GY L    +                    R E 
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACGG +   +G I+SP +P EY  N +C W +VA     ISL F  F+ E     KYD++
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           E+         L     G   P  I S  N +R+ F +D+    +GF A +
Sbjct: 256 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302



 Score =  113 bits (283), Expect = 6e-25
 Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG      G I SP +P  Y+ S  C W I+   G  + +TF+ F+ E +    YD 
Sbjct: 853  APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 908

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
            LEV DG +  S L+G Y G + P  + S+S+ ++L F +D S +  GF +++        
Sbjct: 909  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 968

Query: 550  ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
             C  P     G       +   +   SCD GY L+ ++                C+A CG
Sbjct: 969  SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1028

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +   +G+I SPG+P+ YP + NC W +       +   F  F  E +    +D++ + 
Sbjct: 1029 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1084

Query: 653  SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
               +    L  +  GS+ P  I +  Y N R +  F SD ++S +GF   F
Sbjct: 1085 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134



 Score =  105 bits (262), Expect = 2e-22
 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            +A+CGGDV+   G I SP YP+ Y  S  C W + V+ G  V   F +F +E H    +D
Sbjct: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
            YL + +  S +  L  R  G + P  I +    + R  L+F+SD SI+  GF + F +  
Sbjct: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138

Query: 548  VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
            ++ C  P       R     G   +   SC  GY L                     RC 
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198

Query: 589  AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
            A CG   T   G + SP +P  Y  N  CI+ +       I++    F     DV K   
Sbjct: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255

Query: 649  VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
              +  G    + L G F G S +   ++S  N + +EF SD   + +GF+  + S
Sbjct: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308



 Score =  100 bits (250), Expect = 4e-21
 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            EA+CGG++    G I SP YPD+Y   + C W ++V  G  + + F   + E      YD
Sbjct: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
            ++ V DG  ++S  IG++ G    + + STS+++ +KF SD     +GF V  +   ++ 
Sbjct: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2353

Query: 550  ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
             C  P                       +CL     +G+   +C  G  L  D     C+
Sbjct: 2354 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413

Query: 589  AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
              C     +L+  G I SPG+P  YP  + C W +     Y I++  +FF+TE     ++
Sbjct: 2414 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2469

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            D ++V  G    S +     G       ITS  + + +++ +D+  +KKGF+  + +
Sbjct: 2470 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 119/456 (26%), Positives = 184/456 (40%), Gaps = 80/456 (17%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG T++ S+G  SSP +PN Y  +  C W I   PG+ I L FT   +       YDY+
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433
           E+        P      G  +P PI+S  + L + F + SN   +GF A Y+        
Sbjct: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311

Query: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487
              G++++      G I   + P D   S V    I ++SE   V +T  ++  ++ + S
Sbjct: 312 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 371

Query: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526
              D L      ++S+    R+                 +K  D KS   +L+       
Sbjct: 372 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 429

Query: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584
               +++G I  A    N   +  E     R G +     +LGS  + SCD  Y L   K
Sbjct: 430 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 482

Query: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624
              C+                    CG  L   +G+ TSP +P +Y  N  C+W + A  
Sbjct: 483 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 542

Query: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682
           T   I + F+ F+ E G D     D  EV    T    L G F     P++I S  + M 
Sbjct: 543 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 598

Query: 683 VEFKSDNTVSKKGFKAHFFSV-LEGAGDRHSHLSGL 717
           +  ++D +V   GFK ++  +  E  GD  + L G+
Sbjct: 599 LHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGI 634



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)

Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
           G   SP+YP GY  +++C+W I   PG +I L+F   DL       +D++ V+DG   ++
Sbjct: 690 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 745

Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
           P+ G F G+++P  + S    L +EF++  +  G+GF   Y           +GH + P+
Sbjct: 746 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 796



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG  +    G   SP YP+ Y     C W + V PG  I +NFT L       
Sbjct: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
              YD++ V DG  + +P  G+F G+   E + ST +++ ++F   S++   GFF +
Sbjct: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2345



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)

Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
           EP+  + +G  +   S + ++ +              Y + G K    QR        + 
Sbjct: 451 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 498

Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
            R + K   CG  LQ  +G F+SP +P  Y ++  CVW I+     K+I +NF   DL  
Sbjct: 499 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 557

Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
                YD + + DG     P  +     GS +P+ IVS  S++W+  ++  +    GF  
Sbjct: 558 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 614

Query: 430 VYEAI----CGGDVKKDYG 444
            Y+ I    CG      YG
Sbjct: 615 NYKEIEKESCGDPGTPLYG 633



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  S+G   SP +P+ Y     C W I+V     I L F S  +  +    YD++ 
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            + DG    +PL G F  SKLPE I S+ + + + FRS  +    GF   Y+A
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L    G   SP YP  Y  +++CVW+I+V  G  I +   S     +    +D ++
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1954

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
              DG    AP  G + G+ +P  + ST + L++ F+S  +    GF   Y AI
Sbjct: 1955 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  + D +G   SP +P  Y + + C W I++  G  + L F +     S    +DY+E
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            VR G    + + GR  G ++P  + ST     + F S  +   +GF  VY+A
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)

Query: 444  GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
            G I SP YPD Y   ++C W I V +G+++ +  + F+ E+     +D L+V DG + +S
Sbjct: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2482

Query: 503  STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
              LI     Y    +I S    ++L++ +D   NK GF + +      CS P     G  
Sbjct: 2483 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2540

Query: 560  EQRCLNTLGS-YKCSCDPGYEL 580
              +    L S  + +CD G+ L
Sbjct: 2541 ISQTGGQLNSVVRWACDRGFRL 2562



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%)

Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
           E  CGG ++   G I SP++P++Y  +  C W I    G  + L F  F++E      YD
Sbjct: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
           YLE+    SE  T+     G   P  I S  + L L FV+D +    GF+  +       
Sbjct: 254 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309

Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576
              + G  E+    T G+   +  P
Sbjct: 310 HTTSTGELEEHNRTTTGAIAVASTP 334



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)

Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
           L  G +  +  + KC A CG      +G   SP +P  Y   ++C W I   PG  I + 
Sbjct: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896

Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
           F   + +++ L  YD +EV DG    +PL G + G+++P+ + S+ + +++ F + ++  
Sbjct: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952

Query: 424 GKGFFAVYEAI 434
             GF   YE++
Sbjct: 953 NNGFKIHYESV 963



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG TL+   G   SP +P GY    +C W I      +I + F S  L       YDY+ 
Sbjct: 25  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
           + DG       R R  G  LP P+ ST S   +   S       GF   YE +
Sbjct: 81  LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 133



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG +  ++ G   SP YP  Y  +  C++ I V  G+ I ++  +  L +   
Sbjct: 1194 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1251

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
               D +++ DG  +   L G F G+ +    + ST ++LW+EF S +    +GF  VY +
Sbjct: 1252 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308

Query: 434  ICGGDVKKDYGHIQSPNYP 452
                    +  H + P  P
Sbjct: 1309 F-------ELSHCEDPGIP 1320



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)

Query: 314  RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
            R L  C A CG     S G   SP YP  YS   +CV+ I+V P E ++  F     +++
Sbjct: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769

Query: 373  RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
             L  +D VEV DG  +++ L     GS   E + +S+ +++ + F S      KGF  VY
Sbjct: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827

Query: 432  EAI 434
            +A+
Sbjct: 1828 QAV 1830



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 317  YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
            Y  P+C     G    +S+G   SP YP  Y  ++ C+W I V PG  + L F + D   
Sbjct: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424

Query: 372  SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
            S    +D + V DG      L     GS +PE I ST + + ++F  +  ++ K  FA+
Sbjct: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1478



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  ++  +G   SP YP  Y   ++C W + VT G+ +  NF +  L       +DY+ 
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            + +      PL  R  GS LP  I   ++ L+  FR+   ++
Sbjct: 1083 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1120



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)

Query: 319  CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
            CPA  E   DSTG   SP YP+ Y     C W ISV  G  I +        +     +D
Sbjct: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470

Query: 379  YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
             ++V DG   ++P+     G       I S    +++++ +      KGF   Y A  C 
Sbjct: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2530

Query: 437  GDVKKDYGHIQS 448
                  +G+I S
Sbjct: 2531 TPESPPHGYIIS 2542


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  145 bits (367), Expect = 1e-34
 Identities = 102/280 (36%), Positives = 137/280 (48%), Gaps = 28/280 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG +    G I SP +P +Y  S  C W I +  GF V L F +F  E      +DY
Sbjct: 2005 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2060

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
            LEVR G SE+ST+IGR  G + P  + ST+    L F SD S NK GF + +   ++  C
Sbjct: 2061 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2120

Query: 552  S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
               RP R G       T+G +    C PGY L  +                  RCEA CG
Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2180

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +T +NG+I SPG+P EYP  ++C W +  P    I + F   +TE      YDF+ V 
Sbjct: 2181 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2236

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVS 692
             G   +S   G+F G+   E + S  N + ++F SD T S
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2276



 Score =  144 bits (362), Expect = 4e-34
 Identities = 105/310 (33%), Positives = 146/310 (47%), Gaps = 31/310 (10%)

Query: 433  AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            A CGG  K +  G I SP YP  Y  +  C+W I+V  G  V L F +F+ E     ++D
Sbjct: 1308 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1363

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
             L V DG  E+  L+    G   P+ I ST + + ++F +D  I+K+GFA+ F   V   
Sbjct: 1364 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1423

Query: 552  SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
             R    P  G           +    CDPGYEL  ++R                  C A 
Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1483

Query: 591  CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
            CGG LT  +G I SP +P  YP +++C W +     Y ISL F  F  E N    YDF+ 
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539

Query: 651  VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL-EGAGD 709
            +  G  ++S L G F  S+ PE I S  N M + F+SD +VS  GF   + + L E   D
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1599

Query: 710  RHSHLSGLEL 719
              + ++G  L
Sbjct: 1600 PGNIMNGTRL 1609



 Score =  138 bits (347), Expect = 2e-32
 Identities = 94/292 (32%), Positives = 141/292 (48%), Gaps = 32/292 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           C  +     G + SP+YP+ Y  +  CIW I    G  + L+F  F++E      +D+L 
Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 672

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
           V+DG S  S ++G + G E P  + S S  L L+F +D S++  GF +  N F   +EC 
Sbjct: 673 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 731

Query: 553 RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
            P       R G            CE+  + T G+   +C   D     +    +C A C
Sbjct: 732 DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 791

Query: 592 GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
           GG  +  +G I SPGWP  Y  + NC W + A   + I + F+ F+TE N    YD +EV
Sbjct: 792 GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 847

Query: 652 RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
             G    S L G + G++ P+ + S  N + + F +DN+ S  GFK H+ SV
Sbjct: 848 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 899



 Score =  135 bits (341), Expect = 1e-31
 Identities = 90/284 (31%), Positives = 140/284 (49%), Gaps = 32/284 (11%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + K  G I SP YP+ Y  +  C+W+I V EG  + +   SF  E +    +D L+
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1890

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
              DG   ++  +G Y G   P  + STS+ L+L F SD S++ AGF + +    +D C  
Sbjct: 1891 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 1950

Query: 554  PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
            P          ++  +  + S++C  D GY L           P +R       C A CG
Sbjct: 1951 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2008

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G ++  +G I SPG+P  YP + +C W +  P  + + LQF  F TE      +D++EVR
Sbjct: 2009 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2064

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
            SG +  S + G+  G + P  + S  +   + F SD + +K+GF
Sbjct: 2065 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF 2108



 Score =  135 bits (340), Expect = 2e-31
 Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 40/294 (13%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG++    G I SPN+P  Y  S+ C W I V+  + + L F SF IE +    YD+
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1537

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
            L + DG   +S LIG +   + P+ I+S+S+ + L F SDGS++  GF + +  ++ E C
Sbjct: 1538 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1597

Query: 552  SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
              P       R G + +  +T+  Y   CD GY L               P   R    C
Sbjct: 1598 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             A CG   T   G++ SP +PK Y    NC++ +  P ++ +  QF FF+T  +DV    
Sbjct: 1655 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1710

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700
             VEV  G T  S L     GS   E +  S  N + + F S   ++ KGF  HF
Sbjct: 1711 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HF 1761



 Score =  124 bits (311), Expect = 4e-28
 Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
           CG +++   G   SPN+P  Y  +  C+W I  V+    + + F+ F++E      YD L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 499

Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
            + DG    +  T++    G   PD I S SS++WL   +D S+   GF VN+ + E + 
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559

Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
           C  P     G  E    +     +  C  G+EL  +K                C   C  
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619

Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
             T   G++ SP +P+ Y  N NCIW +++    RI L F+ F+ E     ++DF+ V+ 
Sbjct: 620 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 675

Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
           G + +S + G F G+E P  +TS  + +R+EF++D+++S +GF
Sbjct: 676 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 718



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 36/314 (11%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CG       G + SPNYP +Y     C++ I V + F V   F  F+   HD      
Sbjct: 1656 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1710

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
            +EV DG ++ S+L+    G    + +  S+ +++ ++F S G I   GF   +       
Sbjct: 1711 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1770

Query: 552  SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
            S       E R    +G       S    C+PGY          E  P+           
Sbjct: 1771 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1830

Query: 587  CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
            C   CGG LTK  G+I SPG+P+ Y  N NC+W++  P    I +Q   F TE N    +
Sbjct: 1831 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1886

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV-LE 705
            D ++   G   ++   G + G+  P ++ S  NN+ + F+SD +VS  GF   + ++ L+
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 1946

Query: 706  GAGDRHSHLSGLEL 719
               +  +  SG+++
Sbjct: 1947 SCPEPQTPSSGIKI 1960



 Score =  115 bits (287), Expect = 2e-25
 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CGG +K   G I+SP +P  Y     C W I   E   + + FQSF +E      YDYL 
Sbjct: 65  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           + DGH   +    R  G+  P  + ST S   L+  SD +++  GF V +++E+   S  
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 179

Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
           N G   +  L     +     + SC  GY L    +                    R E 
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACGG +   +G I+SP +P EY  N +C W +VA     ISL F  F+ E     KYD++
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           E+         L     G   P  I S  N +R+ F +D+    +GF A +
Sbjct: 296 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342



 Score =  113 bits (283), Expect = 6e-25
 Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG      G I SP +P  Y+ S  C W I+   G  + +TF+ F+ E +    YD 
Sbjct: 789  APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 844

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
            LEV DG +  S L+G Y G + P  + S+S+ ++L F +D S +  GF +++        
Sbjct: 845  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 904

Query: 550  ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
             C  P     G       +   +   SCD GY L+ ++                C+A CG
Sbjct: 905  SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 964

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +   +G+I SPG+P+ YP + NC W +       +   F  F  E +    +D++ + 
Sbjct: 965  GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1020

Query: 653  SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
               +    L  +  GS+ P  I +  Y N R +  F SD ++S +GF   F
Sbjct: 1021 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1070



 Score =  105 bits (262), Expect = 2e-22
 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            +A+CGGDV+   G I SP YP+ Y  S  C W + V+ G  V   F +F +E H    +D
Sbjct: 960  DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1015

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
            YL + +  S +  L  R  G + P  I +    + R  L+F+SD SI+  GF + F +  
Sbjct: 1016 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074

Query: 548  VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
            ++ C  P       R     G   +   SC  GY L                     RC 
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134

Query: 589  AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
            A CG   T   G + SP +P  Y  N  CI+ +       I++    F     DV K   
Sbjct: 1135 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1191

Query: 649  VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
              +  G    + L G F G S +   ++S  N + +EF SD   + +GF+  + S
Sbjct: 1192 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1244



 Score =  100 bits (250), Expect = 4e-21
 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            EA+CGG++    G I SP YPD+Y   + C W ++V  G  + + F   + E      YD
Sbjct: 2176 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2231

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
            ++ V DG  ++S  IG++ G    + + STS+++ +KF SD     +GF V  +   ++ 
Sbjct: 2232 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2289

Query: 550  ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
             C  P                       +CL     +G+   +C  G  L  D     C+
Sbjct: 2290 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2349

Query: 589  AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
              C     +L+  G I SPG+P  YP  + C W +     Y I++  +FF+TE     ++
Sbjct: 2350 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2405

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            D ++V  G    S +     G       ITS  + + +++ +D+  +KKGF+  + +
Sbjct: 2406 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2462



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 96/345 (27%), Positives = 139/345 (40%), Gaps = 71/345 (20%)

Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
           E  CGG ++   G I SP++P++Y  +  C W I    G  + L F  F++E      YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           YLE+    SE  T+     G   P  I S  + L L FV+D +    GF+  +   K +D
Sbjct: 294 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAID 349

Query: 550 ECSRP----------------NRGG---CEQRCLN--------------TLGS-YKCSCD 575
             SR                 N GG       C +              +LGS  + SCD
Sbjct: 350 FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCD 409

Query: 576 PGYELAPDKR-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKN 616
             Y L   K   C+                    CG  L   +G+ TSP +P +Y  N  
Sbjct: 410 EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQ 469

Query: 617 CIWQLVA-PTQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEV 673
           C+W + A  T   I + F+ F+ E G D     D  EV    T    L G F     P++
Sbjct: 470 CVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDL 525

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSV-LEGAGDRHSHLSGL 717
           I S  + M +  ++D +V   GFK ++  +  E  GD  + L G+
Sbjct: 526 IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGI 570



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)

Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
           G   SP+YP GY  +++C+W I   PG +I L+F   DL       +D++ V+DG   ++
Sbjct: 626 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 681

Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
           P+ G F G+++P  + S    L +EF++  +  G+GF   Y           +GH + P+
Sbjct: 682 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 732



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 8/112 (7%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG T++ S+G  SSP +PN Y  +  C W I   PG+ I L FT   +       YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE 432
           E+        P      G  +P PI+S  + L + F + SN   +GF A Y+
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG  +    G   SP YP+ Y     C W + V PG  I +NFT L       
Sbjct: 2172 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2229

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
              YD++ V DG  + +P  G+F G+   E + ST +++ ++F   S++   GFF +
Sbjct: 2230 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2281



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)

Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
           EP+  + +G  +   S + ++ +              Y + G K    QR        + 
Sbjct: 387 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 434

Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
            R + K   CG  LQ  +G F+SP +P  Y ++  CVW I+     K+I +NF   DL  
Sbjct: 435 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 493

Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
                YD + + DG     P  +     GS +P+ IVS  S++W+  ++  +    GF  
Sbjct: 494 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 550

Query: 430 VYEAI----CGGDVKKDYG 444
            Y+ I    CG      YG
Sbjct: 551 NYKEIEKESCGDPGTPLYG 569



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  S+G   SP +P+ Y     C W I+V     I L F S  +  +    YD++ 
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            + DG    +PL G F  SKLPE I S+ + + + FRS  +    GF   Y+A
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1591



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L    G   SP YP  Y  +++CVW+I+V  G  I +   S     +    +D ++
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1890

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
              DG    AP  G + G+ +P  + ST + L++ F+S  +    GF   Y AI
Sbjct: 1891 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 1943



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  + D +G   SP +P  Y + + C W I++  G  + L F +     S    +DY+E
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2062

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            VR G    + + GR  G ++P  + ST     + F S  +   +GF  VY+A
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2114



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)

Query: 444  GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
            G I SP YPD Y   ++C W I V +G+++ +  + F+ E+     +D L+V DG + +S
Sbjct: 2363 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2418

Query: 503  STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
              LI     Y    +I S    ++L++ +D   NK GF + +      CS P     G  
Sbjct: 2419 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2476

Query: 560  EQRCLNTLGS-YKCSCDPGYEL 580
              +    L S  + +CD G+ L
Sbjct: 2477 ISQTGGQLNSVVRWACDRGFRL 2498



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)

Query: 305 LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
           L  G +  +  + KC A CG      +G   SP +P  Y   ++C W I   PG  I + 
Sbjct: 773 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 832

Query: 364 FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
           F   + +++ L  YD +EV DG    +PL G + G+++P+ + S+ + +++ F + ++  
Sbjct: 833 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 888

Query: 424 GKGFFAVYEAI 434
             GF   YE++
Sbjct: 889 NNGFKIHYESV 899



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG +  ++ G   SP YP  Y  +  C++ I V  G+ I ++  +  L +   
Sbjct: 1130 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1187

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
               D +++ DG  +   L G F G+ +    + ST ++LW+EF S +    +GF  VY +
Sbjct: 1188 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1244

Query: 434  ICGGDVKKDYGHIQSPNYP 452
                    +  H + P  P
Sbjct: 1245 F-------ELSHCEDPGIP 1256



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)

Query: 314  RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
            R L  C A CG     S G   SP YP  YS   +CV+ I+V P E ++  F     +++
Sbjct: 1649 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1705

Query: 373  RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
             L  +D VEV DG  +++ L     GS   E + +S+ +++ + F S      KGF  VY
Sbjct: 1706 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1763

Query: 432  EAI 434
            +A+
Sbjct: 1764 QAV 1766



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 317  YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
            Y  P+C     G    +S+G   SP YP  Y  ++ C+W I V PG  + L F + D   
Sbjct: 1301 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1360

Query: 372  SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
            S    +D + V DG      L     GS +PE I ST + + ++F  +  ++ K  FA+
Sbjct: 1361 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1414



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  ++  +G   SP YP  Y   ++C W + VT G+ +  NF +  L       +DY+ 
Sbjct: 963  CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1018

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            + +      PL  R  GS LP  I   ++ L+  FR+   ++
Sbjct: 1019 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1056



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)

Query: 319  CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
            CPA  E   DSTG   SP YP+ Y     C W ISV  G  I +        +     +D
Sbjct: 2352 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2406

Query: 379  YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
             ++V DG   ++P+     G       I S    +++++ +      KGF   Y A  C 
Sbjct: 2407 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2466

Query: 437  GDVKKDYGHIQS 448
                  +G+I S
Sbjct: 2467 TPESPPHGYIIS 2478


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  145 bits (367), Expect = 1e-34
 Identities = 102/280 (36%), Positives = 137/280 (48%), Gaps = 28/280 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG +    G I SP +P +Y  S  C W I +  GF V L F +F  E      +DY
Sbjct: 2109 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2164

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDEC 551
            LEVR G SE+ST+IGR  G + P  + ST+    L F SD S NK GF + +   ++  C
Sbjct: 2165 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2224

Query: 552  S--RPNRGGCEQRCLNTLG-SYKCSCDPGYELAPDKR----------------RCEAACG 592
               RP R G       T+G +    C PGY L  +                  RCEA CG
Sbjct: 2225 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2284

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +T +NG+I SPG+P EYP  ++C W +  P    I + F   +TE      YDF+ V 
Sbjct: 2285 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2340

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVS 692
             G   +S   G+F G+   E + S  N + ++F SD T S
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS 2380



 Score =  144 bits (362), Expect = 4e-34
 Identities = 105/310 (33%), Positives = 146/310 (47%), Gaps = 31/310 (10%)

Query: 433  AICGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            A CGG  K +  G I SP YP  Y  +  C+W I+V  G  V L F +F+ E     ++D
Sbjct: 1412 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1467

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
             L V DG  E+  L+    G   P+ I ST + + ++F +D  I+K+GFA+ F   V   
Sbjct: 1468 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1527

Query: 552  SR----PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRR-----------------CEAA 590
             R    P  G           +    CDPGYEL  ++R                  C A 
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1587

Query: 591  CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
            CGG LT  +G I SP +P  YP +++C W +     Y ISL F  F  E N    YDF+ 
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643

Query: 651  VRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVL-EGAGD 709
            +  G  ++S L G F  S+ PE I S  N M + F+SD +VS  GF   + + L E   D
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFD 1703

Query: 710  RHSHLSGLEL 719
              + ++G  L
Sbjct: 1704 PGNIMNGTRL 1713



 Score =  138 bits (347), Expect = 2e-32
 Identities = 94/292 (32%), Positives = 141/292 (48%), Gaps = 32/292 (10%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            C  +     G + SP+YP+ Y  +  CIW I    G  + L+F  F++E      +D+L 
Sbjct: 721  CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLA 776

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV--NFFKEVDECS 552
            V+DG S  S ++G + G E P  + S S  L L+F +D S++  GF +  N F   +EC 
Sbjct: 777  VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH-NECP 835

Query: 553  RPN------RGG------------CEQRCLNTLGSYKCSC---DPGYELAPDKRRCEAAC 591
             P       R G            CE+  + T G+   +C   D     +    +C A C
Sbjct: 836  DPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPC 895

Query: 592  GGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV 651
            GG  +  +G I SPGWP  Y  + NC W + A   + I + F+ F+TE N    YD +EV
Sbjct: 896  GGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLEV 951

Query: 652  RSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703
              G    S L G + G++ P+ + S  N + + F +DN+ S  GFK H+ SV
Sbjct: 952  HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 1003



 Score =  135 bits (341), Expect = 1e-31
 Identities = 90/284 (31%), Positives = 140/284 (49%), Gaps = 32/284 (11%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + K  G I SP YP+ Y  +  C+W+I V EG  + +   SF  E +    +D L+
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1994

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDECSR 553
              DG   ++  +G Y G   P  + STS+ L+L F SD S++ AGF + +    +D C  
Sbjct: 1995 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPE 2054

Query: 554  PNRGGC-----EQRCLNTLGSYKCSCDPGYEL----------APDKRR------CEAACG 592
            P          ++  +  + S++C  D GY L           P +R       C A CG
Sbjct: 2055 PQTPSSGIKIGDRYMVGDVVSFQC--DQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG 2112

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G ++  +G I SPG+P  YP + +C W +  P  + + LQF  F TE      +D++EVR
Sbjct: 2113 GAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLEVR 2168

Query: 653  SGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
            SG +  S + G+  G + P  + S  +   + F SD + +K+GF
Sbjct: 2169 SGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF 2212



 Score =  135 bits (340), Expect = 2e-31
 Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 40/294 (13%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG++    G I SPN+P  Y  S+ C W I V+  + + L F SF IE +    YD+
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1641

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE-C 551
            L + DG   +S LIG +   + P+ I+S+S+ + L F SDGS++  GF + +  ++ E C
Sbjct: 1642 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1701

Query: 552  SRPN------RGGCEQRCLNTLGSYKCSCDPGYELA--------------PDKRR----C 587
              P       R G + +  +T+  Y   CD GY L               P   R    C
Sbjct: 1702 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758

Query: 588  EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647
             A CG   T   G++ SP +PK Y    NC++ +  P ++ +  QF FF+T  +DV    
Sbjct: 1759 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV---- 1814

Query: 648  FVEVRSGLTADSKLHGKFCGSEKPEVI-TSQYNNMRVEFKSDNTVSKKGFKAHF 700
             VEV  G T  S L     GS   E +  S  N + + F S   ++ KGF  HF
Sbjct: 1815 -VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HF 1865



 Score =  124 bits (311), Expect = 4e-28
 Identities = 84/283 (29%), Positives = 138/283 (48%), Gaps = 29/283 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQ-VSEGFHVGLTFQSFEIERHDSCAYDYL 493
           CG +++   G   SPN+P  Y  +  C+W I  V+    + + F+ F++E      YD L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 603

Query: 494 EVRDGHS--ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK-EVDE 550
            + DG    +  T++    G   PD I S SS++WL   +D S+   GF VN+ + E + 
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663

Query: 551 CSRPNR---GGCEQRCLNTLGSYKCSCDPGYELAPDKRR--------------CEAACGG 593
           C  P     G  E    +     +  C  G+EL  +K                C   C  
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723

Query: 594 FLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRS 653
             T   G++ SP +P+ Y  N NCIW +++    RI L F+ F+ E     ++DF+ V+ 
Sbjct: 724 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKD 779

Query: 654 GLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696
           G + +S + G F G+E P  +TS  + +R+EF++D+++S +GF
Sbjct: 780 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 822



 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/314 (27%), Positives = 139/314 (44%), Gaps = 36/314 (11%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CG       G + SPNYP +Y     C++ I V + F V   F  F+   HD      
Sbjct: 1760 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1814

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIK-STSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
            +EV DG ++ S+L+    G    + +  S+ +++ ++F S G I   GF   +       
Sbjct: 1815 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1874

Query: 552  SRPNRGGCEQRCLNTLG-------SYKCSCDPGY----------ELAPDKRR-------- 586
            S       E R    +G       S    C+PGY          E  P+           
Sbjct: 1875 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1934

Query: 587  CEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
            C   CGG LTK  G+I SPG+P+ Y  N NC+W++  P    I +Q   F TE N    +
Sbjct: 1935 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1990

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV-LE 705
            D ++   G   ++   G + G+  P ++ S  NN+ + F+SD +VS  GF   + ++ L+
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2050

Query: 706  GAGDRHSHLSGLEL 719
               +  +  SG+++
Sbjct: 2051 SCPEPQTPSSGIKI 2064



 Score =  115 bits (287), Expect = 2e-25
 Identities = 88/291 (30%), Positives = 126/291 (43%), Gaps = 38/291 (13%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CGG +K   G I+SP +P  Y     C W I   E   + + FQSF +E      YDYL 
Sbjct: 65  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           + DGH   +    R  G+  P  + ST S   L+  SD +++  GF V +++E+   S  
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 179

Query: 555 NRGGCEQRCL-----NTLGSYKCSCDPGYELAPDKR--------------------RCEA 589
           N G   +  L     +     + SC  GY L    +                    R E 
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACGG +   +G I+SP +P EY  N +C W +VA     ISL F  F+ E     KYD++
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
           E+         L     G   P  I S  N +R+ F +D+    +GF A +
Sbjct: 296 EIEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342



 Score =  113 bits (283), Expect = 6e-25
 Identities = 84/291 (28%), Positives = 132/291 (45%), Gaps = 32/291 (10%)

Query: 433  AICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492
            A CGG      G I SP +P  Y+ S  C W I+   G  + +TF+ F+ E +    YD 
Sbjct: 893  APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDV 948

Query: 493  LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK---EVD 549
            LEV DG +  S L+G Y G + P  + S+S+ ++L F +D S +  GF +++        
Sbjct: 949  LEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTY 1008

Query: 550  ECSRPN---RGGCEQRCLNTLGSYKCSCDPGYELAPDKR--------------RCEAACG 592
             C  P     G       +   +   SCD GY L+ ++                C+A CG
Sbjct: 1009 SCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCG 1068

Query: 593  GFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVR 652
            G +   +G+I SPG+P+ YP + NC W +       +   F  F  E +    +D++ + 
Sbjct: 1069 GDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLIT 1124

Query: 653  SGLTADSKLHGKFCGSEKPEVITS-QYNNMRVE--FKSDNTVSKKGFKAHF 700
               +    L  +  GS+ P  I +  Y N R +  F SD ++S +GF   F
Sbjct: 1125 ENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1174



 Score =  105 bits (262), Expect = 2e-22
 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 34/295 (11%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            +A+CGGDV+   G I SP YP+ Y  S  C W + V+ G  V   F +F +E H    +D
Sbjct: 1064 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1119

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKS---TSSRLWLKFVSDGSINKAGFAVNFFK-E 547
            YL + +  S +  L  R  G + P  I +    + R  L+F+SD SI+  GF + F +  
Sbjct: 1120 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178

Query: 548  VDECSRPNRGGCEQRCLNTLG---SYKCSCDPGYELAPDKR----------------RCE 588
            ++ C  P       R     G   +   SC  GY L                     RC 
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238

Query: 589  AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDF 648
            A CG   T   G + SP +P  Y  N  CI+ +       I++    F     DV K   
Sbjct: 1239 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1295

Query: 649  VEVRSGLTADSKLHGKFCG-SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
              +  G    + L G F G S +   ++S  N + +EF SD   + +GF+  + S
Sbjct: 1296 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1348



 Score =  100 bits (250), Expect = 4e-21
 Identities = 79/297 (26%), Positives = 135/297 (45%), Gaps = 36/297 (12%)

Query: 432  EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
            EA+CGG++    G I SP YPD+Y   + C W ++V  G  + + F   + E      YD
Sbjct: 2280 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2335

Query: 492  YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK--EVD 549
            ++ V DG  ++S  IG++ G    + + STS+++ +KF SD     +GF V  +   ++ 
Sbjct: 2336 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLR 2393

Query: 550  ECSRPN----------------RGGCEQRCL---NTLGSYKCSCDPGYELAPDKRR--CE 588
             C  P                       +CL     +G+   +C  G  L  D     C+
Sbjct: 2394 VCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2453

Query: 589  AACGGFLTKLN--GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
              C     +L+  G I SPG+P  YP  + C W +     Y I++  +FF+TE     ++
Sbjct: 2454 VLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EF 2509

Query: 647  DFVEVRSGLTADSKLHGKFCGSEKPEV-ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            D ++V  G    S +     G       ITS  + + +++ +D+  +KKGF+  + +
Sbjct: 2510 DVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2566



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 119/456 (26%), Positives = 184/456 (40%), Gaps = 80/456 (17%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG T++ S+G  SSP +PN Y  +  C W I   PG+ I L FT   +       YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE-------A 433
           E+        P      G  +P PI+S  + L + F + SN   +GF A Y+        
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 351

Query: 434 ICGGDVKK----DYGHIQSPNYPDDYRPSKVCIWRI-QVSEGFHVGLT-FQSFEIERHDS 487
              G++++      G I   + P D   S V    I ++SE   V +T  ++  ++ + S
Sbjct: 352 TSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTS 411

Query: 488 CAYDYLEVRDGHSESSTLIGRYC--------------GYEKPDDIKSTSSRLW------- 526
              D L      ++S+    R+                 +K  D KS   +L+       
Sbjct: 412 --KDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSN 469

Query: 527 -LKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGS-YKCSCDPGYELAPDK 584
               +++G I  A    N   +  E     R G +     +LGS  + SCD  Y L   K
Sbjct: 470 KFSILNEGGIKTAS---NLCPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAK 522

Query: 585 R-RCE------------------AACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-P 624
              C+                    CG  L   +G+ TSP +P +Y  N  C+W + A  
Sbjct: 523 SITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVN 582

Query: 625 TQYRISLQFDFFETE-GNDVCKY-DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMR 682
           T   I + F+ F+ E G D     D  EV    T    L G F     P++I S  + M 
Sbjct: 583 TNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFV----PDLIVSMSSQMW 638

Query: 683 VEFKSDNTVSKKGFKAHFFSV-LEGAGDRHSHLSGL 717
           +  ++D +V   GFK ++  +  E  GD  + L G+
Sbjct: 639 LHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGI 674



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 13/120 (10%)

Query: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
           G   SP+YP GY  +++C+W I   PG +I L+F   DL       +D++ V+DG   ++
Sbjct: 730 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPES 785

Query: 391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPN 450
           P+ G F G+++P  + S    L +EF++  +  G+GF   Y           +GH + P+
Sbjct: 786 PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT---------FGHNECPD 836



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 38/116 (32%), Positives = 58/116 (50%), Gaps = 7/116 (6%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG  +    G   SP YP+ Y     C W + V PG  I +NFT L       
Sbjct: 2276 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2333

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
              YD++ V DG  + +P  G+F G+   E + ST +++ ++F   S++   GFF +
Sbjct: 2334 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH--SDFTTSGFFVL 2385



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 23/199 (11%)

Query: 253 EPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQ 312
           EP+  + +G  +   S + ++ +              Y + G K    QR        + 
Sbjct: 491 EPENGKRIGSDFSLGSTVQFSCDE------------DYVLQGAKSITCQRIAEVFAAWSD 538

Query: 313 ARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKII-LNFTSLDLYR 371
            R + K   CG  LQ  +G F+SP +P  Y ++  CVW I+     K+I +NF   DL  
Sbjct: 539 HRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE- 597

Query: 372 SRLCWYDYVEVRDGFWRKAP--LRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFA 429
                YD + + DG     P  +     GS +P+ IVS  S++W+  ++  +    GF  
Sbjct: 598 ---IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKV 654

Query: 430 VYEAI----CGGDVKKDYG 444
            Y+ I    CG      YG
Sbjct: 655 NYKEIEKESCGDPGTPLYG 673



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/112 (34%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  S+G   SP +P+ Y     C W I+V     I L F S  +  +    YD++ 
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            + DG    +PL G F  SKLPE I S+ + + + FRS  +    GF   Y+A
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1695



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 4/113 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L    G   SP YP  Y  +++CVW+I+V  G  I +   S     +    +D ++
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WDSLD 1994

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
              DG    AP  G + G+ +P  + ST + L++ F+S  +    GF   Y AI
Sbjct: 1995 FYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2047



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 4/112 (3%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  + D +G   SP +P  Y + + C W I++  G  + L F +     S    +DY+E
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2166

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            VR G    + + GR  G ++P  + ST     + F S  +   +GF  VY+A
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2218



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 11/142 (7%)

Query: 444  GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG-HSES 502
            G I SP YPD Y   ++C W I V +G+++ +  + F+ E+     +D L+V DG + +S
Sbjct: 2467 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQS 2522

Query: 503  STLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN---RGGC 559
              LI     Y    +I S    ++L++ +D   NK GF + +      CS P     G  
Sbjct: 2523 PVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI--AFYCSTPESPPHGYI 2580

Query: 560  EQRCLNTLGS-YKCSCDPGYEL 580
              +    L S  + +CD G+ L
Sbjct: 2581 ISQTGGQLNSVVRWACDRGFRL 2602



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 42/145 (28%), Positives = 63/145 (43%), Gaps = 8/145 (5%)

Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
           E  CGG ++   G I SP++P++Y  +  C W I    G  + L F  F++E      YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
           YLE+    SE  T+     G   P  I S  + L L FV+D +    GF+  +       
Sbjct: 294 YLEIEG--SEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 349

Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDP 576
              + G  E+    T G+   +  P
Sbjct: 350 HTTSTGELEEHNRTTTGAIAVASTP 374



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 5/131 (3%)

Query: 305  LSKGDIAQARKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILN 363
            L  G +  +  + KC A CG      +G   SP +P  Y   ++C W I   PG  I + 
Sbjct: 877  LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 936

Query: 364  FTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            F   + +++ L  YD +EV DG    +PL G + G+++P+ + S+ + +++ F + ++  
Sbjct: 937  F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 992

Query: 424  GKGFFAVYEAI 434
              GF   YE++
Sbjct: 993  NNGFKIHYESV 1003



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 4/113 (3%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG TL+   G   SP +P GY    +C W I      +I + F S  L       YDY+ 
Sbjct: 65  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
           + DG       R R  G  LP P+ ST S   +   S       GF   YE +
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEEL 173



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 14/139 (10%)

Query: 316  LYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRL 374
            L +C A CG +  ++ G   SP YP  Y  +  C++ I V  G+ I ++  +  L +   
Sbjct: 1234 LPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-- 1291

Query: 375  CWYDYVEVRDGFWRKAPLRGRFCGSKLPE-PIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
               D +++ DG  +   L G F G+ +    + ST ++LW+EF S +    +GF  VY +
Sbjct: 1292 ---DVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1348

Query: 434  ICGGDVKKDYGHIQSPNYP 452
                    +  H + P  P
Sbjct: 1349 F-------ELSHCEDPGIP 1360



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)

Query: 314  RKLYKCPA-CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRS 372
            R L  C A CG     S G   SP YP  YS   +CV+ I+V P E ++  F     +++
Sbjct: 1753 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1809

Query: 373  RLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI-VSTDSRLWVEFRSSSNWVGKGFFAVY 431
             L  +D VEV DG  +++ L     GS   E + +S+ +++ + F S      KGF  VY
Sbjct: 1810 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1867

Query: 432  EAI 434
            +A+
Sbjct: 1868 QAV 1870



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 37/119 (31%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 317  YKCPAC-----GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYR 371
            Y  P+C     G    +S+G   SP YP  Y  ++ C+W I V PG  + L F + D   
Sbjct: 1405 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1464

Query: 372  SRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAV 430
            S    +D + V DG      L     GS +PE I ST + + ++F  +  ++ K  FA+
Sbjct: 1465 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQF-DTDFYISKSGFAI 1518



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  ++  +G   SP YP  Y   ++C W + VT G+ +  NF +  L       +DY+ 
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1122

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
            + +      PL  R  GS LP  I   ++ L+  FR+   ++
Sbjct: 1123 ITENGSFTQPL-ARLTGSDLPPTI---NAGLYGNFRAQLRFI 1160



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 37/132 (28%), Positives = 54/132 (40%), Gaps = 7/132 (5%)

Query: 319  CPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYD 378
            CPA  E   DSTG   SP YP+ Y     C W ISV  G  I +        +     +D
Sbjct: 2456 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2510

Query: 379  YVEVRDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI-CG 436
             ++V DG   ++P+     G       I S    +++++ +      KGF   Y A  C 
Sbjct: 2511 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCS 2570

Query: 437  GDVKKDYGHIQS 448
                  +G+I S
Sbjct: 2571 TPESPPHGYIIS 2582


>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
          Length = 609

 Score =  139 bits (350), Expect = 1e-32
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206

Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score =  130 bits (326), Expect = 6e-30
 Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 53/284 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
           ECS+                                          T  +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           ++CG + P  I S    + + F +D+ ++K+GF A+ +SVL+ +
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN-YSVLQSS 268



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204

Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263

Query: 434 ICGGDVKKDY 443
           +    V +D+
Sbjct: 264 VLQSSVSEDF 273


>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
          Length = 644

 Score =  139 bits (350), Expect = 1e-32
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206

Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score =  130 bits (326), Expect = 6e-30
 Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 53/284 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
           ECS+                                          T  +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           ++CG + P  I S    + + F +D+ ++K+GF A+ +SVL+ +
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN-YSVLQSS 268



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204

Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263

Query: 434 ICGGDVKKDY 443
           +    V +D+
Sbjct: 264 VLQSSVSEDF 273


>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
          Length = 923

 Score =  139 bits (350), Expect = 1e-32
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206

Query: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score =  130 bits (326), Expect = 6e-30
 Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 53/284 (18%)

Query: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145

Query: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
           ECS+                                          T  +G I SPG+P+
Sbjct: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165

Query: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225

Query: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
           ++CG + P  I S    + + F +D+ ++K+GF A+ +SVL+ +
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN-YSVLQSS 268



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204

Query: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263

Query: 434 ICGGDVKKDY 443
           +    V +D+
Sbjct: 264 VLQSSVSEDF 273


>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
          Length = 1662

 Score =  138 bits (348), Expect = 2e-32
 Identities = 107/386 (27%), Positives = 170/386 (44%), Gaps = 40/386 (10%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  ++G FSSP YP  Y  +  CVW I V  G +I L F++L L     C +DYVE
Sbjct: 1015 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1074

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
            + DG    + L G+ C     +   S+ +R+ + FRS  ++   GF A Y +        
Sbjct: 1075 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDAT-- 1131

Query: 442  DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
                ++  N    Y    +C  R+++  G   G     S+ I+  +         R   +
Sbjct: 1132 ----LRLVNLNSSYG---LCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA 1184

Query: 501  ESSTLIGRYCGYEKPDDIK--STSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
              +   G   G    DD++   T S LW         N+  F+ N       C+     G
Sbjct: 1185 LGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHN-------CNHREDAG 1231

Query: 559  --CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
              C    L+T         P   L   +   + +CGGFL++ +G  +SP +P  YP N  
Sbjct: 1232 VICSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAK 1282

Query: 617  CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
            C+W +     YR+++ F   + EG   C YD++EV  G    S L  + C   +    TS
Sbjct: 1283 CVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGS-FTS 1339

Query: 677  QYNNMRVEFKSDNTVSKKGFKAHFFS 702
              N M + F SD++++++GF+A ++S
Sbjct: 1340 SSNFMSIRFISDHSITRRGFRAEYYS 1365



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)

Query: 586  RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
            R  + CGGFL   +G+ +SP +P  YP N  C+W++   + YRI+L F   + E +  C 
Sbjct: 1010 RPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCS 1069

Query: 646  YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            +D+VE+  G    S L GK C   + ++ TS YN M + F+SD +    GF A + S
Sbjct: 1070 FDYVEIFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1125



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + +  G   SP YP +Y  +  C+W I+V   + V + F+  ++E    C YDY+E
Sbjct: 1257 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1314

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            V DG   SS LI R C   +     S+S+ + ++F+SD SI + GF   ++      S P
Sbjct: 1315 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYY------SSP 1367

Query: 555  NRGGCEQRCL 564
            +       CL
Sbjct: 1368 SNDSTNLLCL 1377



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 3/111 (2%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            +CG  L   +G+FSSP YP  Y  +  CVW I V    ++ + F  + L     C YDY+
Sbjct: 1256 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYI 1313

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
            EV DG +R +PL  R C         S+ + + + F S  +   +GF A Y
Sbjct: 1314 EVFDGPYRSSPLIARVCDGARGS-FTSSSNFMSIRFISDHSITRRGFRAEY 1363


>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
          Length = 1788

 Score =  138 bits (348), Expect = 2e-32
 Identities = 107/386 (27%), Positives = 170/386 (44%), Gaps = 40/386 (10%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  ++G FSSP YP  Y  +  CVW I V  G +I L F++L L     C +DYVE
Sbjct: 1141 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1200

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
            + DG    + L G+ C     +   S+ +R+ + FRS  ++   GF A Y +        
Sbjct: 1201 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDAT-- 1257

Query: 442  DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
                ++  N    Y    +C  R+++  G   G     S+ I+  +         R   +
Sbjct: 1258 ----LRLVNLNSSYG---LCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA 1310

Query: 501  ESSTLIGRYCGYEKPDDIK--STSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
              +   G   G    DD++   T S LW         N+  F+ N       C+     G
Sbjct: 1311 LGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHN-------CNHREDAG 1357

Query: 559  --CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
              C    L+T         P   L   +   + +CGGFL++ +G  +SP +P  YP N  
Sbjct: 1358 VICSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAK 1408

Query: 617  CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
            C+W +     YR+++ F   + EG   C YD++EV  G    S L  + C   +    TS
Sbjct: 1409 CVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGS-FTS 1465

Query: 677  QYNNMRVEFKSDNTVSKKGFKAHFFS 702
              N M + F SD++++++GF+A ++S
Sbjct: 1466 SSNFMSIRFISDHSITRRGFRAEYYS 1491



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)

Query: 586  RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
            R  + CGGFL   +G+ +SP +P  YP N  C+W++   + YRI+L F   + E +  C 
Sbjct: 1136 RPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCS 1195

Query: 646  YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            +D+VE+  G    S L GK C   + ++ TS YN M + F+SD +    GF A + S
Sbjct: 1196 FDYVEIFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1251



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + +  G   SP YP +Y  +  C+W I+V   + V + F+  ++E    C YDY+E
Sbjct: 1383 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1440

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            V DG   SS LI R C   +     S+S+ + ++F+SD SI + GF   ++      S P
Sbjct: 1441 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYY------SSP 1493

Query: 555  NRGGCEQRCL 564
            +       CL
Sbjct: 1494 SNDSTNLLCL 1503



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 3/111 (2%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            +CG  L   +G+FSSP YP  Y  +  CVW I V    ++ + F  + L     C YDY+
Sbjct: 1382 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYI 1439

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
            EV DG +R +PL  R C         S+ + + + F S  +   +GF A Y
Sbjct: 1440 EVFDGPYRSSPLIARVCDGARGS-FTSSSNFMSIRFISDHSITRRGFRAEY 1489


>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
            [Homo sapiens]
          Length = 2403

 Score =  138 bits (348), Expect = 2e-32
 Identities = 107/386 (27%), Positives = 170/386 (44%), Gaps = 40/386 (10%)

Query: 322  CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
            CG  L  ++G FSSP YP  Y  +  CVW I V  G +I L F++L L     C +DYVE
Sbjct: 1756 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1815

Query: 382  VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
            + DG    + L G+ C     +   S+ +R+ + FRS  ++   GF A Y +        
Sbjct: 1816 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDAT-- 1872

Query: 442  DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
                ++  N    Y    +C  R+++  G   G     S+ I+  +         R   +
Sbjct: 1873 ----LRLVNLNSSYG---LCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA 1925

Query: 501  ESSTLIGRYCGYEKPDDIK--STSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGG 558
              +   G   G    DD++   T S LW         N+  F+ N       C+     G
Sbjct: 1926 LGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHN-------CNHREDAG 1972

Query: 559  --CEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
              C    L+T         P   L   +   + +CGGFL++ +G  +SP +P  YP N  
Sbjct: 1973 VICSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAK 2023

Query: 617  CIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITS 676
            C+W +     YR+++ F   + EG   C YD++EV  G    S L  + C   +    TS
Sbjct: 2024 CVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGS-FTS 2080

Query: 677  QYNNMRVEFKSDNTVSKKGFKAHFFS 702
              N M + F SD++++++GF+A ++S
Sbjct: 2081 SSNFMSIRFISDHSITRRGFRAEYYS 2106



 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)

Query: 586  RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
            R  + CGGFL   +G+ +SP +P  YP N  C+W++   + YRI+L F   + E +  C 
Sbjct: 1751 RPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCS 1810

Query: 646  YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            +D+VE+  G    S L GK C   + ++ TS YN M + F+SD +    GF A + S
Sbjct: 1811 FDYVEIFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1866



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)

Query: 435  CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
            CGG + +  G   SP YP +Y  +  C+W I+V   + V + F+  ++E    C YDY+E
Sbjct: 1998 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 2055

Query: 495  VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
            V DG   SS LI R C   +     S+S+ + ++F+SD SI + GF   ++      S P
Sbjct: 2056 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYY------SSP 2108

Query: 555  NRGGCEQRCL 564
            +       CL
Sbjct: 2109 SNDSTNLLCL 2118



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 3/111 (2%)

Query: 321  ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
            +CG  L   +G+FSSP YP  Y  +  CVW I V    ++ + F  + L     C YDY+
Sbjct: 1997 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYI 2054

Query: 381  EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
            EV DG +R +PL  R C         S+ + + + F S  +   +GF A Y
Sbjct: 2055 EVFDGPYRSSPLIARVCDGARGS-FTSSSNFMSIRFISDHSITRRGFRAEY 2104


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,294,142
Number of Sequences: 37866
Number of extensions: 1895666
Number of successful extensions: 8256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 194
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 6168
Number of HSP's gapped (non-prelim): 1435
length of query: 823
length of database: 18,247,518
effective HSP length: 111
effective length of query: 712
effective length of database: 14,044,392
effective search space: 9999607104
effective search space used: 9999607104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press