Search of human proteins with 58761492

Search of human proteins with 58761492

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58761492 Rho guanine nucleotide exchange factor (GEF)
10-like isoform 1 [Homo sapiens]
         (1279 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...  2570   0.0  
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...  2473   0.0  
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...   936   0.0  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   162   2e-39
gi|94557295 mitogen-activated protein kinase 8 interacting prote...   112   2e-24
gi|94557297 mitogen-activated protein kinase 8 interacting prote...   112   2e-24
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        105   4e-22
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        105   4e-22
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   103   1e-21
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]      103   1e-21
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]       103   1e-21
gi|229094128 active breakpoint cluster region-related  protein i...    94   1e-18
gi|38679957 active breakpoint cluster region-related  protein is...    94   1e-18
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    91   7e-18
gi|38679954 active breakpoint cluster region-related  protein is...    91   7e-18
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    87   1e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    87   1e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                86   3e-16
gi|118150678 epithelial cell transforming sequence 2 oncogene-li...    84   7e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    84   9e-16
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    84   9e-16
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    79   4e-14
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              78   5e-14
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    78   6e-14
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    76   2e-13
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    76   2e-13
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    74   7e-13
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    74   7e-13
gi|71274148 pleckstrin homology domain containing, family G (wit...    73   2e-12
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    72   3e-12

>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score = 2570 bits (6662), Expect = 0.0
 Identities = 1279/1279 (100%), Positives = 1279/1279 (100%)

Query: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60
            MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
Sbjct: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60

Query: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120
            TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
Sbjct: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120

Query: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180
            TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
Sbjct: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180

Query: 181  SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD 240
            SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD
Sbjct: 181  SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD 240

Query: 241  CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 300
            CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
Sbjct: 241  CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 300

Query: 301  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360
            PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
Sbjct: 301  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360

Query: 361  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420
            VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
Sbjct: 361  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420

Query: 421  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480
            MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
Sbjct: 421  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480

Query: 481  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540
            PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
Sbjct: 481  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540

Query: 541  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600
            ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
Sbjct: 541  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600

Query: 601  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660
            WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
Sbjct: 601  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660

Query: 661  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720
            KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
Sbjct: 661  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720

Query: 721  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780
            KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
Sbjct: 721  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780

Query: 781  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 840
            PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
Sbjct: 781  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 840

Query: 841  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 900
            IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
Sbjct: 841  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 900

Query: 901  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 960
            GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
Sbjct: 901  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 960

Query: 961  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 1020
            ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
Sbjct: 961  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 1020

Query: 1021 KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1080
            KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
Sbjct: 1021 KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1080

Query: 1081 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1140
            GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
Sbjct: 1081 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1140

Query: 1141 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1200
            PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
Sbjct: 1141 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1200

Query: 1201 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1260
            LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
Sbjct: 1201 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1260

Query: 1261 APCGETDSTLLIWQVPLML 1279
            APCGETDSTLLIWQVPLML
Sbjct: 1261 APCGETDSTLLIWQVPLML 1279


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score = 2473 bits (6409), Expect = 0.0
 Identities = 1240/1279 (96%), Positives = 1240/1279 (96%), Gaps = 39/1279 (3%)

Query: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60
            MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
Sbjct: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60

Query: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120
            TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
Sbjct: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120

Query: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180
            TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
Sbjct: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180

Query: 181  SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD 240
            SGEEAKPEVEVEPAKHRVSFQPK                                     
Sbjct: 181  SGEEAKPEVEVEPAKHRVSFQPK------------------------------------- 203

Query: 241  CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 300
              MTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
Sbjct: 204  --MTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 261

Query: 301  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360
            PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
Sbjct: 262  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 321

Query: 361  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420
            VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
Sbjct: 322  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 381

Query: 421  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480
            MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
Sbjct: 382  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 441

Query: 481  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540
            PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
Sbjct: 442  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 501

Query: 541  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600
            ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
Sbjct: 502  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 561

Query: 601  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660
            WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
Sbjct: 562  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 621

Query: 661  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720
            KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
Sbjct: 622  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 681

Query: 721  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780
            KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
Sbjct: 682  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 741

Query: 781  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 840
            PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
Sbjct: 742  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 801

Query: 841  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 900
            IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
Sbjct: 802  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 861

Query: 901  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 960
            GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
Sbjct: 862  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 921

Query: 961  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 1020
            ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
Sbjct: 922  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 981

Query: 1021 KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1080
            KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
Sbjct: 982  KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1041

Query: 1081 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1140
            GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
Sbjct: 1042 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1101

Query: 1141 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1200
            PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
Sbjct: 1102 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1161

Query: 1201 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1260
            LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
Sbjct: 1162 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1221

Query: 1261 APCGETDSTLLIWQVPLML 1279
            APCGETDSTLLIWQVPLML
Sbjct: 1222 APCGETDSTLLIWQVPLML 1240


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score =  936 bits (2419), Expect = 0.0
 Identities = 535/1168 (45%), Positives = 730/1168 (62%), Gaps = 51/1168 (4%)

Query: 127  EDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAE-DLGWSSSEFESYSEDSGEEA 185
            E+ IYDDVP E+ D+        ++Y+D         +  + GWSSSEFESY E S  E 
Sbjct: 210  EEAIYDDVPRENSDSEPD----EMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSEC 265

Query: 186  KPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQ 245
            K  +    +  R + + +LS DLTRLKE Y +  RD++A  VG  ++Q+L+ K++ KM +
Sbjct: 266  KNGIP--RSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQK 323

Query: 246  LMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDS-----EEEDMGLLEVSVSDIKPPA 300
            L+KAAK GTKDGLE+TR AV R  SF+  K ++        EEE    ++V   D K P 
Sbjct: 324  LVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDV---DCKHPE 380

Query: 301  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360
              L PMPEGLS QQVVRR+ILGS+V SE +YV++LKRIL+ Y  PL EMEPK LS RK +
Sbjct: 381  AILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLK 440

Query: 361  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420
             VF+RVKEIL CHS+FQIAL+SRV+EWDS E IGD+FVASFSKSMVLD YS+YVNNF++A
Sbjct: 441  TVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTA 500

Query: 421  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480
            ++++KK C TKPAFLEFLK+ Q  SPDR TLY LM+KPIQRFPQFILLLQDMLKNT +GH
Sbjct: 501  VAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGH 560

Query: 481  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540
            PDRL LQ+ALTELETLAEKLNE+KR ADQ  E++Q+ K++++R  LNKLL+SG R L+  
Sbjct: 561  PDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINER-YLNKLLSSGSRYLIRS 619

Query: 541  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600
            + + ETVY DRG+++K+KERRVF+LND+L+CA ++ +P++        S V    +Y++K
Sbjct: 620  DDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSH-------DSRVMSSQRYLLK 672

Query: 601  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660
            W+  L  V  +E G   GT +    L  H     A  +    NKVY+GP +L+Q+LQ+L 
Sbjct: 673  WSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLL 732

Query: 661  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720
             DL V+ QIT LI  L G YQNLN +VA DW   LQRL+  KE+EI +A+ CR++L LPG
Sbjct: 733  HDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPG 792

Query: 721  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780
            K DKSGRP  F  VF T  P  K SWVN L +AK+ L EEN  GW C ++D         
Sbjct: 793  KQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKH 852

Query: 781  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAV--STSLPQGYLWVGGGQEGAGGQ 838
            P+L   +P   ++    ++    ++P   P L   +   S S   G+LW+G       GQ
Sbjct: 853  PLLVGHMPVMVAKQQEFKIECAAYNPE--PYLNNESQPDSFSTAHGFLWIGSCTHQM-GQ 909

Query: 839  VEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS--ATVHPTICL 896
            + I S    +P+ ++ F + + +LCM Y+P +EE+       P    P+  A+  PTIC+
Sbjct: 910  IAIVSFQNSTPKVIECFNVESRILCMLYVP-VEEKRREPGAPPDPETPAVRASDVPTICV 968

Query: 897  GLQDGSILLYSSVDTGTQC-LVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGG 955
            G ++GSI +Y S     +  L    +P    V+ L  +   L AGL +G +A+Y R   G
Sbjct: 969  GTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDG 1028

Query: 956  VLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015
              WD E P   + +G  PVR+LL +ED +WA+ G +V ++   T   +   EAHQ+E + 
Sbjct: 1029 -SWDSE-PQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMV 1086

Query: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQ 1075
            ++HM  +G G+W+AF+SG+++RLFHTETL+HLQ+INIAT    +LPG + L VTSLL+C 
Sbjct: 1087 ISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCH 1146

Query: 1076 GLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQ 1135
            GLL VGT  GV+V LPVPRL+GIPK+TG+GMVS + H  PV F+ +AT++   D  +S  
Sbjct: 1147 GLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRD 1206

Query: 1136 EEAEGPR-AEEDKPDGQAHEPMPDSHVGRELTR---KKGILLQYRLRSTAHLPGPLLSMR 1191
              A GP   +ED+ D      +P    G  L++      I L   L S         S  
Sbjct: 1207 SLAPGPEPQDEDQKDA-----LPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSG 1261

Query: 1192 EPAPADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNF 1250
              + + G ++LEH  ED +IY++  DP   V  R  AR A + +  S  ++ GGQG+R  
Sbjct: 1262 SLSLSHGSSSLEHRSEDSTIYDLLKDP---VSLRSKARRAKKAKASSALVVCGGQGHRR- 1317

Query: 1251 GSALGSSGRQAPCGETDSTLLIWQVPLM 1278
               +    RQ    E   T+++WQ+PL+
Sbjct: 1318 ---VHRKARQPHQEELAPTVMVWQIPLL 1342


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  162 bits (410), Expect = 2e-39
 Identities = 146/602 (24%), Positives = 269/602 (44%), Gaps = 83/602 (13%)

Query: 299  PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 356
            PA E  P  +  S  QV +R+H+  +++ +E SYVESL+ ++Q Y  PL + E   L   
Sbjct: 1048 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 1107

Query: 357  RKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 416
                 +F ++ E+L  H  F   +   +  W + +K+G L V SFSK +++++YS Y++N
Sbjct: 1108 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 1167

Query: 417  FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 476
            F +A   ++ A   +PAFL+FL++    + ++  L  LM+KP+QR P++ LL++D+LK+T
Sbjct: 1168 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 1227

Query: 477  PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 532
            P  HPD   L  A   ++ +AE++N+  R A++       +Q++   +     L   L  
Sbjct: 1228 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 1287

Query: 533  GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 588
              RQ ++ E   + + G        K+R +FL  D++VC  +  K  +  R  + +   +
Sbjct: 1288 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 1338

Query: 589  SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLG 648
            S++    KY + W   L    +++                         + QA N+    
Sbjct: 1339 SVIDTASKYKMLWKLPLEDADIIK------------------------GASQATNR---- 1370

Query: 649  PPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHS 708
               + + +  L +DL  + Q++ L  +L   +Q+L+    +D   A+ R +  K+   ++
Sbjct: 1371 -ENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLD-DALRDLSAAMHRDLSEKQALCYA 1428

Query: 709  ANKCRLRL-LLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC 767
             +    +L L   +P+ +        +F  P+P +++ +      AK  L         C
Sbjct: 1429 LSFPPTKLELCATRPEGTD-----SYIFEFPHPDARLGFEQAFDEAKRKLASSKS----C 1479

Query: 768  PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLW 827
             D           P     IP   +R+  +Q      +  +CP           P   +W
Sbjct: 1480 LD-----------PEFLKAIPIMKTRS-GMQFSCAAPTLNSCP----------EPSPEVW 1517

Query: 828  VGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS 887
            V    +G  GQV + SL             +A +LC+  +P L+     R+  P++  P 
Sbjct: 1518 V-CNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCH-REPPPSLRSPP 1575

Query: 888  AT 889
             T
Sbjct: 1576 ET 1577



 Score =  114 bits (285), Expect = 6e-25
 Identities = 112/411 (27%), Positives = 159/411 (38%), Gaps = 100/411 (24%)

Query: 885  DPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDG 944
            DP A    ++ LG +DG + +Y S D+      S +      V C+ +    +   L +G
Sbjct: 1733 DPEA-YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANG 1791

Query: 945  TLAAYPRTSGGVLWDLES-PPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQ 1003
             L  Y R +G   WD ++   V L     P+  ++S+   +W  C  RV VL   TLQ +
Sbjct: 1792 ELVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLE 1850

Query: 1004 QSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG- 1062
              F   QD +  V  MV +  GVW+       + L+H +T E L E+++      +L G 
Sbjct: 1851 HMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1910

Query: 1063 ----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPV-PRLEGIPKI----TGKGMVSL 1109
                ++H    L +T+LL+C+ LLWVGT  GV++ +P  P     P+     TG G    
Sbjct: 1911 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLG---- 1966

Query: 1110 NGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDG---QAHEPMPDSHVGRELT 1166
             GH G V FLA                           PDG       P P    G E  
Sbjct: 1967 QGHTGHVRFLAAV-----------------------QLPDGFNLLCPTPPPPPDTGPE-- 2001

Query: 1167 RKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPC 1226
                     +L S  H   P    R PAPA                           RP 
Sbjct: 2002 ---------KLPSLEHRDSPW--HRGPAPA---------------------------RP- 2022

Query: 1227 ARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDST--LLIWQV 1275
                       + +ISGG GY +F  + G        G  DST  LL+W+V
Sbjct: 2023 ----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV 2063


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 846  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 896
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 909  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 967

Query: 897  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 956
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 968  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1025

Query: 957  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 1026 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1084

Query: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1071
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 1085 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1144

Query: 1072 LICQGLLWVGTDQGVIVLLPV 1092
            L+    LWVGT  GV++ +P+
Sbjct: 1145 LVAGSRLWVGTGNGVVISIPL 1165


>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 846  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 896
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 915  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 973

Query: 897  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 956
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 974  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1031

Query: 957  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 1032 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1090

Query: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1071
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 1091 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1150

Query: 1072 LICQGLLWVGTDQGVIVLLPV 1092
            L+    LWVGT  GV++ +P+
Sbjct: 1151 LVAGSRLWVGTGNGVVISIPL 1171


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  105 bits (261), Expect = 4e-22
 Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 316 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 372
           +R+ +L  I+ SE +Y+  L+ +L   + PL      +   L++++ + +FF+V E+   
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMK-PLKAAATTSQPVLTSQQIETIFFKVPELYEI 556

Query: 373 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 432
           H  F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C    
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613

Query: 433 AFLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 485
            F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPL 673

Query: 486 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 545
           LQ AL   +     +NE+                ++ R     +     RQLL    + E
Sbjct: 674 LQDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVE 717

Query: 546 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 593
            V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 718 LVEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  105 bits (261), Expect = 4e-22
 Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 316 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 372
           +R+ +L  I+ SE +Y+  L+ +L   + PL      +   L++++ + +FF+V E+   
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMK-PLKAAATTSQPVLTSQQIETIFFKVPELYEI 556

Query: 373 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 432
           H  F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C    
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613

Query: 433 AFLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 485
            F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPL 673

Query: 486 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 545
           LQ AL   +     +NE+                ++ R     +     RQLL    + E
Sbjct: 674 LQDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVE 717

Query: 546 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 593
            V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 718 LVEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score =  103 bits (256), Expect = 1e-21
 Identities = 79/271 (29%), Positives = 134/271 (49%), Gaps = 16/271 (5%)

Query: 313 QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEI 369
           +Q  R  +   + Q+E +YV  L  I+Q ++ PL E   +    L+  + + +F  + +I
Sbjct: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477

Query: 370 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 429
              H+  +  L   +  WD ++ IGD+F+  +SK +V   Y  +VN F  +   I K   
Sbjct: 478 FDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPPFVNFFEMSKETIIKCEK 535

Query: 430 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
            KP F  FLK  Q   P+  R +L  L+++P+QR P   LLL D+ K+T   +PD+ +L+
Sbjct: 536 QKPRFHAFLKINQA-KPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 594

Query: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 547
            A+  L+ +   +NE KR  +   +I  +   V    +   LL+S +  +   ET++   
Sbjct: 595 KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPA--NLLSSHRSLVQRVETISLGE 652

Query: 548 YG-DRGQLIKSKERRVFLLNDMLVCANINFK 577
           +  DRG+ +      +FL ND L  A    K
Sbjct: 653 HPCDRGEQV-----TLFLFNDCLEIARKRHK 678


>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 884  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 943
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 962  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1019

Query: 944  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 1002
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 1020 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078

Query: 1003 QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1061
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138

Query: 1062 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1099
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1182


>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 884  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 943
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 948  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1005

Query: 944  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 1002
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 1006 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064

Query: 1003 QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1061
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124

Query: 1062 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1099
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1168


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 81/303 (26%), Positives = 130/303 (42%), Gaps = 42/303 (13%)

Query: 307 PEGLSPQQV------VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSAR 357
           PEGL+P         +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ +
Sbjct: 30  PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQ 88

Query: 358 KCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNF 417
           + + +F+++++I   H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+
Sbjct: 89  QIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNY 145

Query: 418 TSAMSIIKKACLTKPAFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQ 470
             A+   +K   +   F +  +  +V  P         VT+  L+ KPI R  +  L+L 
Sbjct: 146 KVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLH 205

Query: 471 DMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLL 530
           D+LK+TP  HPD   LQ AL   +     +NE                 +  R +     
Sbjct: 206 DLLKHTPVDHPDYPLLQDALRISQNFLSSINED----------------IDPRRTAVTTP 249

Query: 531 TSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSL 590
               RQL+    L E     R      K R VFL  D+L+CA +    A    Q +    
Sbjct: 250 KGETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY 303

Query: 591 VPL 593
           +PL
Sbjct: 304 IPL 306


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 81/303 (26%), Positives = 130/303 (42%), Gaps = 42/303 (13%)

Query: 307 PEGLSPQQV------VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSAR 357
           PEGL+P         +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ +
Sbjct: 76  PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQ 134

Query: 358 KCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNF 417
           + + +F+++++I   H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+
Sbjct: 135 QIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNY 191

Query: 418 TSAMSIIKKACLTKPAFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQ 470
             A+   +K   +   F +  +  +V  P         VT+  L+ KPI R  +  L+L 
Sbjct: 192 KVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLH 251

Query: 471 DMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLL 530
           D+LK+TP  HPD   LQ AL   +     +NE                 +  R +     
Sbjct: 252 DLLKHTPVDHPDYPLLQDALRISQNFLSSINED----------------IDPRRTAVTTP 295

Query: 531 TSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSL 590
               RQL+    L E     R      K R VFL  D+L+CA +    A    Q +    
Sbjct: 296 KGETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY 349

Query: 591 VPL 593
           +PL
Sbjct: 350 IPL 352


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 89/330 (26%), Positives = 155/330 (46%), Gaps = 29/330 (8%)

Query: 300 APELGPMPEGLSPQQV----VRRHILGSIVQSEGSYVESLKRI----LQDYRNPLMEMEP 351
           AP  GP P   + +      +R  +L  I+ +E  YV +L+ +    L   R  + +   
Sbjct: 29  APSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVE 88

Query: 352 KALSARKCQVVFFRVKEILHCHSMFQIALSSRV-AEWDSTEKIGDLFVASFSKSMVLDVY 410
           K L+    +V+F  +++IL  H  F  AL   +  E  S  ++G++F+    K  V   Y
Sbjct: 89  KGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCV---Y 145

Query: 411 SDYVNNFTSAMSIIKKACLTK-PAFLEFLKRRQVCSPDRVT---LYGLMVKPIQRFPQFI 466
            +Y +N   A+ ++ +  L K P    FL    +    + T   L G ++ PIQR  ++ 
Sbjct: 146 EEYCSNHEKALRLLVE--LNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYP 203

Query: 467 LLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSL 526
           LLL+++ K TP  HPD  ++Q AL  ++T+   +NE KR  +++  ++QL   +      
Sbjct: 204 LLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGS 263

Query: 527 NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLE 586
           N  LT    QLLL  TL +   G+       +ER  FL +++LV      +    +   +
Sbjct: 264 N--LTDICTQLLLQGTLLKISAGN------IQERAFFLFDNLLVYCKRKSRVTGSKKSTK 315

Query: 587 ISSLVPLGPKYVVKW--NTALPQVQVVEVG 614
            +  +  G  Y+ +   NT + +V+ VE G
Sbjct: 316 RTKSIN-GSLYIFRGRINTEVMEVENVEDG 344


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 76/288 (26%), Positives = 124/288 (43%), Gaps = 36/288 (12%)

Query: 316 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 372
           +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ ++ + +F+++++I   
Sbjct: 54  MRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQQIETIFYKIQDIYEI 112

Query: 373 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 432
           H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+  A+   +K   +  
Sbjct: 113 HKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCSQSNN 169

Query: 433 AFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 485
            F +  +  +V  P         VT+  L+ KPI R  +  L+L D+LK+TP  HPD   
Sbjct: 170 QFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPL 229

Query: 486 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 545
           LQ AL   +     +NE                 +  R +         RQL+    L E
Sbjct: 230 LQDALRISQNFLSSINED----------------IDPRRTAVTTPKGETRQLVKDGFLVE 273

Query: 546 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 593
                R      K R VFL  D+L+CA +    A    Q +    +PL
Sbjct: 274 VSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPL 315


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 282 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 340
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181

Query: 341 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 396
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236

Query: 397 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 451
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289

Query: 452 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 511
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349

Query: 512 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 567
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397

Query: 568 MLV 570
           M++
Sbjct: 398 MIL 400


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 282 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 340
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181

Query: 341 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 396
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236

Query: 397 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 451
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289

Query: 452 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 511
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349

Query: 512 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 567
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397

Query: 568 MLV 570
           M++
Sbjct: 398 MIL 400


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 74/289 (25%), Positives = 139/289 (48%), Gaps = 22/289 (7%)

Query: 310  LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEI 369
            L+P +  R+  +  ++ +E +YV  L+ + + ++ PLME E   L+ ++  ++F   KE+
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESE--LLTEKEVAMIFVNWKEL 1288

Query: 370  LHCHSMFQIALSSRVAEWDSTEK-----IGDLFVASFSKSMVLDVYSDYVNNFTSAMSII 424
            + C+     AL  RV +  S EK     IGD+  A       +  Y  + +   +  ++I
Sbjct: 1289 IMCNIKLLKAL--RVRKKMSGEKMPVKMIGDILSAQLPH---MQPYIRFCSRQLNGAALI 1343

Query: 425  KKACLTKPAFLEFLKRRQVCSPDR-VTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDR 483
            ++     P F EF+KR  +    + + L   ++KP+QR  ++ L+++++L+NTP  HPD 
Sbjct: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403

Query: 484  LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETL 543
              L+ AL + E L  ++NE  R  +    ++ +   V       +L+ +      +   L
Sbjct: 1404 SHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS-----VTNCL 1458

Query: 544  TETVYGDRGQLIKSKERRV---FLLNDMLVCANINFKPANHRGQLEISS 589
                +   G+L K+K  +    FL ND L+   I  KP    G  ++ S
Sbjct: 1459 GPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQIT-KPLGSSGTDKVFS 1506


>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
           [Homo sapiens]
          Length = 904

 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 69/266 (25%), Positives = 127/266 (47%), Gaps = 15/266 (5%)

Query: 317 RRHILGSIVQSEGSYVESLKRILQDYRNPL---MEMEPKALSARKCQVVFFRVKEILHCH 373
           R  ++  ++QSE  YV+ L+ +   Y  PL   +      LSA   Q++F  + +IL  +
Sbjct: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626

Query: 374 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 433
             F   L  R+ EW     +G++ V  F     L+ Y+++ NN+   +  I+K     PA
Sbjct: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683

Query: 434 FLEFLKRR-QVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 492
           F  FLKR  +      ++L  L++ P +RF +++ LL  +  +TP  H DR  L  A+ +
Sbjct: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743

Query: 493 LETLAEKLNEQKR---LADQVAEIQQLTKSVSDRSSLNKLLTSGQ--RQLLLCETLTETV 547
           ++     +++ K+   + D +++IQ++       S +N+ L   Q   QL  C+   E +
Sbjct: 744 IKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCD---EEI 800

Query: 548 YGDRGQLIKSKERRVFLLNDMLVCAN 573
                      +  +FL ND L+ ++
Sbjct: 801 SFSLRLYEHIHDLSLFLFNDALLVSS 826


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 84.0 bits (206), Expect = 9e-16
 Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 44/304 (14%)

Query: 320 ILGSIVQSEGSYVESLKRILQDYRNPLMEMEPK-ALSARKCQVVFFRVKEILHCHSMFQI 378
           I   ++ +E +YV  L  + Q +   L+E   + +  A     +F  +  I   HS F +
Sbjct: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269

Query: 379 A-LSSRVAEWDSTEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF- 434
             L  R+ EW++T +IGD+   +A F K     +Y +YV  F +AM ++K      P F 
Sbjct: 270 PELEKRMQEWETTPRIGDILQKLAPFLK-----MYGEYVKGFDNAMELVKNMTERIPQFK 324

Query: 435 --LEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 492
             +E ++++++C    +TL   M++P+QR P++ +LL+D L+  P    D    + +L  
Sbjct: 325 SVVEEIQKQKICGS--LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382

Query: 493 LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVY 548
           + T A   N   R  + + ++ ++ + + +   +    N+L+  GQ   L     +    
Sbjct: 383 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTS---- 438

Query: 549 GDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQV 608
                   ++ER +FL N+ML+     F            SLV  G K+ V+    +  +
Sbjct: 439 --------AQERYLFLFNNMLLYCVPKF------------SLV--GSKFTVRTRVGIDGM 476

Query: 609 QVVE 612
           ++VE
Sbjct: 477 KIVE 480


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 84.0 bits (206), Expect = 9e-16
 Identities = 69/285 (24%), Positives = 135/285 (47%), Gaps = 23/285 (8%)

Query: 306 MPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFR 365
           +P    P ++ R  +   IV++E +YV  L+ I++DY  PL++     LS  +   +F  
Sbjct: 94  IPGSARPSRLER--VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFAN 151

Query: 366 VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIK 425
           +++I      F   L   +    S   I + FV    +S   D+Y+ Y  N+ S++++++
Sbjct: 152 IEDIYE----FSSELLEDLENSSSAGGIAECFV---QRSEDFDIYTLYCMNYPSSLALLR 204

Query: 426 KACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPR--GHPDR 483
           +  L+ PA L +L+ RQ      + L   ++KP+QR  ++ LLLQ++ K+     G   R
Sbjct: 205 ELSLSPPAAL-WLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGR 263

Query: 484 LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETL 543
             ++ A+  +  +A  +N+ KR  +  A +Q++ + +           +G       E +
Sbjct: 264 EMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGG--------WTGPELSAFGELV 315

Query: 544 TETVY---GDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQL 585
            E  +   G  G  ++  ER +FL + ML+ A        ++G +
Sbjct: 316 LEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI 360


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 67/233 (28%), Positives = 108/233 (46%), Gaps = 15/233 (6%)

Query: 311 SPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEM--EPKALSARKCQVVFFRVKE 368
           S  Q   + I+  ++++E +YV  L  + Q +   L++     KA      +V+F  +  
Sbjct: 97  SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISS 156

Query: 369 ILHCHSMFQIA-LSSRVAEWDSTEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIK 425
           I   HS F +  L  R+ +W +  +IGD+   +A F K     +YS+YV NF  A  ++ 
Sbjct: 157 IYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLK-----MYSEYVKNFERAAELLA 211

Query: 426 KACLTKPAFLEFLKRRQVCSPD-RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRL 484
                 P F E L R Q       +TL   M++P+QR P++ LLL++ ++  P   PD+ 
Sbjct: 212 TWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQA 271

Query: 485 SLQLALTELETLAEKLN----EQKRLADQVAEIQQLTKSVSDRSSLNKLLTSG 533
             Q AL  + + A+  N    E +RL D     Q+L          N LL  G
Sbjct: 272 DAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREG 324


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 74/249 (29%), Positives = 118/249 (47%), Gaps = 20/249 (8%)

Query: 275 KDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPE-GLSPQQVVRRHILGSIVQSEGSYVE 333
           ++V  D EEED    E    D + P P +       L+ QQ V  HI   ++Q+E +YV 
Sbjct: 333 QEVDSDLEEED-DEEEEEEKDREIPVPLMERQESVELTVQQKVF-HIANELLQTEKAYVS 390

Query: 334 SLKRILQDYRNPLMEMEPKALSARKCQVV---FFRVKEILHCHSMFQIA-LSSRVAEWDS 389
            L  + Q +   L+E E +  S+    VV   F  +  I   H  F +  L  R+ EWD 
Sbjct: 391 RLHLLDQVFCARLLE-EARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDR 449

Query: 390 TEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF---LEFLKRRQVC 444
             +IGD+   +A F K     +Y +YV NF  A+ ++         F   +  +++ + C
Sbjct: 450 YPRIGDILQKLAPFLK-----MYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEAC 504

Query: 445 SPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQK 504
               +TL   M++P+QR P++ LLL+D L   P G PD    Q +L  + T AE  N   
Sbjct: 505 G--NLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAI 562

Query: 505 RLADQVAEI 513
           R  +++ ++
Sbjct: 563 RKMERMHKL 571


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 61/253 (24%), Positives = 114/253 (45%), Gaps = 15/253 (5%)

Query: 275  KDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVES 334
            ++++  S+E+D+     S S    P P      E    +  V  HI   I+ SE  +V+ 
Sbjct: 835  EEIINSSDEDDVS----SESSKGEPDPLEDKQDEDNGMKSKVH-HIAKEIMSSEKVFVDV 889

Query: 335  LKRILQDYRNPLM----EMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDST 390
            LK +  D+R+ +     ++    +  R    + + + ++   +      L  R+  W   
Sbjct: 890  LKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQ 949

Query: 391  EKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPD--R 448
            ++I D+FV    K   L +YS Y+  F   ++++ + C   P F   ++  ++ SP    
Sbjct: 950  QRIADIFV---KKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEM-SPRCAN 1005

Query: 449  VTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLAD 508
            + L   ++KP+QR PQ+ LLL D LKN      D    Q AL  +  +A   N+  +  D
Sbjct: 1006 LALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGD 1065

Query: 509  QVAEIQQLTKSVS 521
               ++ Q+  S++
Sbjct: 1066 NFQKLMQIQYSLN 1078


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 9/263 (3%)

Query: 308 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVK 367
           E  S +  +R +++  I+ +E  Y++ L+ I + Y     +      S  + + +F  ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334

Query: 368 EILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKA 427
           +I  C   F  AL  R         + +L            +YS+Y NN  +A   + + 
Sbjct: 335 DIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL 392

Query: 428 CLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
                    F   R +     ++L G ++ P+Q+  ++ L L ++LK T   H D   ++
Sbjct: 393 TKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 547
            AL  ++ +A+ +NE+KR  + + +I Q   S+ D    + L+ S   +L+    LT   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSS--ELIYSGELTRVT 510

Query: 548 YGDRGQLIKSKERRVFLLNDMLV 570
                   KS++R  FL +  L+
Sbjct: 511 QPQ----AKSQQRMFFLFDHQLI 529


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 9/263 (3%)

Query: 308 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVK 367
           E  S +  +R +++  I+ +E  Y++ L+ I + Y     +      S  + + +F  ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334

Query: 368 EILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKA 427
           +I  C   F  AL  R         + +L            +YS+Y NN  +A   + + 
Sbjct: 335 DIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL 392

Query: 428 CLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
                    F   R +     ++L G ++ P+Q+  ++ L L ++LK T   H D   ++
Sbjct: 393 TKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 547
            AL  ++ +A+ +NE+KR  + + +I Q   S+ D    + L+ S   +L+    LT   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSS--ELIYSGELTRVT 510

Query: 548 YGDRGQLIKSKERRVFLLNDMLV 570
                   KS++R  FL +  L+
Sbjct: 511 QPQ----AKSQQRMFFLFDHQLI 529


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 63/251 (25%), Positives = 124/251 (49%), Gaps = 37/251 (14%)

Query: 317 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQV-------VFFRVKEI 369
           R  ++ S++++E  YV+ L  ++ ++  PL      A S++K  +       +F   + I
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLR----MAASSKKPPITHDDVSSIFLNSETI 296

Query: 370 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 429
           +  H +F   L +R++ W  T  + DLF        +L++Y ++V N   ++ I+   C 
Sbjct: 297 MFLHQIFYQGLKARISSWP-TLVLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CK 351

Query: 430 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
               F + LK  +   PD    TL   +  P+ + P++IL L ++L +TP  H +R SL 
Sbjct: 352 QNRDFDKLLKHYEA-KPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLD 410

Query: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET- 546
            A ++LE L+  ++      D+V+E + + K++    ++ +++  G      CE L +T 
Sbjct: 411 YAKSKLEELSRIMH------DEVSETENIRKNL----AIERMIIEG------CEILLDTS 454

Query: 547 -VYGDRGQLIK 556
             +  +G LI+
Sbjct: 455 QTFVRQGSLIQ 465


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 63/251 (25%), Positives = 124/251 (49%), Gaps = 37/251 (14%)

Query: 317 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQV-------VFFRVKEI 369
           R  ++ S++++E  YV+ L  ++ ++  PL      A S++K  +       +F   + I
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLR----MAASSKKPPITHDDVSSIFLNSETI 296

Query: 370 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 429
           +  H +F   L +R++ W  T  + DLF        +L++Y ++V N   ++ I+   C 
Sbjct: 297 MFLHQIFYQGLKARISSWP-TLVLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CK 351

Query: 430 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
               F + LK  +   PD    TL   +  P+ + P++IL L ++L +TP  H +R SL 
Sbjct: 352 QNRDFDKLLKHYEA-KPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLD 410

Query: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET- 546
            A ++LE L+  ++      D+V+E + + K++    ++ +++  G      CE L +T 
Sbjct: 411 YAKSKLEELSRIMH------DEVSETENIRKNL----AIERMIIEG------CEILLDTS 454

Query: 547 -VYGDRGQLIK 556
             +  +G LI+
Sbjct: 455 QTFVRQGSLIQ 465


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/269 (20%), Positives = 124/269 (46%), Gaps = 12/269 (4%)

Query: 311 SPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEIL 370
           SP+ +    ++  I+++E +YV+ LK I++DY + + +     L   +   +F  +++I 
Sbjct: 108 SPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIY 167

Query: 371 HCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 430
           H +S  ++       E D    I + FV   SKS    +Y+ Y  N+  +++++ + C+ 
Sbjct: 168 HFNS--ELLQDLENCENDPV-AIAECFV---SKSEEFHIYTQYCTNYPRSVAVLTE-CMR 220

Query: 431 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLAL 490
                +F + RQ      + L   ++KP+QR  ++ LLL ++  +  +       +  A+
Sbjct: 221 NKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAI 280

Query: 491 TELETLAEKLNEQKRLADQVAEIQQLTKSVS-----DRSSLNKLLTSGQRQLLLCETLTE 545
             ++ +A  +N+ KR  +    +Q++   ++     D +S  +L+  G  ++   +    
Sbjct: 281 DTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERT 340

Query: 546 TVYGDRGQLIKSKERRVFLLNDMLVCANI 574
               D+  LI  K    F     ++C N+
Sbjct: 341 LFLFDKLLLITKKRDDTFTYKAHILCGNL 369


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 69/273 (25%), Positives = 131/273 (47%), Gaps = 27/273 (9%)

Query: 310  LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEI 369
            + P +  R+  +  ++Q+E  Y+  L+ +++ ++  + E     L+  +  ++F   KE+
Sbjct: 1176 MQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESG--FLTEGEMALIFVNWKEL 1233

Query: 370  LHCHSMFQIALSSRV---AEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKK 426
            +  ++    AL  R     E    + IGD+  A  S    +  Y  + +   +  +++++
Sbjct: 1234 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSH---MQAYIRFCSCQLNGAALLQQ 1290

Query: 427  ACLTKPAFLEFLKRRQVCSPDR---VTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDR 483
                   F EFLK+  + S  R   + L   ++KP+QR  ++ LL++ +L+NTP  H D 
Sbjct: 1291 KTDEDTDFKEFLKK--LASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1348

Query: 484  LSLQLALTELETLAEKLNE---QKRLADQVAEIQQ--LTKSVSDRSSLNKLLTS-GQRQL 537
             SL+LAL   E L  ++NE   +K  +D++  IQ     + ++++   N L    G R+L
Sbjct: 1349 SSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKL 1408

Query: 538  LLCETLTETVYGDRGQLIKSKERRVFLLNDMLV 570
            L    L +T          +KE   FL ND L+
Sbjct: 1409 LHSGKLYKTK--------SNKELHGFLFNDFLL 1433


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,544,344
Number of Sequences: 37866
Number of extensions: 2859977
Number of successful extensions: 11090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 10662
Number of HSP's gapped (non-prelim): 466
length of query: 1279
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1165
effective length of database: 13,930,794
effective search space: 16229375010
effective search space used: 16229375010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.