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Search of human proteins with 58530886
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap... 1269 0.0
gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2... 250 2e-66
gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1... 240 2e-63
gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3... 213 3e-55
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 148 1e-35
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 148 1e-35
gi|216547519 interleukin-1 receptor-associated kinase 3 isoform ... 134 3e-31
gi|216547504 interleukin-1 receptor-associated kinase 3 isoform ... 134 3e-31
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 134 3e-31
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 134 3e-31
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 134 3e-31
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 75 2e-13
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens] 67 4e-11
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 67 4e-11
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 67 4e-11
gi|4505001 LIM domain kinase 1 [Homo sapiens] 67 4e-11
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 67 6e-11
gi|83776600 aurora kinase B [Homo sapiens] 65 2e-10
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 65 2e-10
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 64 4e-10
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 64 5e-10
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 64 5e-10
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 63 7e-10
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 63 7e-10
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 63 7e-10
>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
sapiens]
Length = 625
Score = 1269 bits (3283), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITREL 60
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITREL
Sbjct: 1 MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITREL 60
Query: 61 LWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASV 120
LWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASV
Sbjct: 61 LWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASV 120
Query: 121 RKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST 180
RKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
Sbjct: 121 RKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST 180
Query: 181 SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLR 240
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLR
Sbjct: 181 SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLR 240
Query: 241 ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQG 300
ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQG
Sbjct: 241 ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQG 300
Query: 301 QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP 360
QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
Sbjct: 301 QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP 360
Query: 361 VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS 420
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS
Sbjct: 361 VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS 420
Query: 421 PVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACL 480
PVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACL
Sbjct: 421 PVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACL 480
Query: 481 CLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDAS 540
CLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDAS
Sbjct: 481 CLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDAS 540
Query: 541 SSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINE 600
SSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINE
Sbjct: 541 SSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINE 600
Query: 601 AKRKLMENILLYKEEKVDSIELFGP 625
AKRKLMENILLYKEEKVDSIELFGP
Sbjct: 601 AKRKLMENILLYKEEKVDSIELFGP 625
>gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2
[Homo sapiens]
Length = 682
Score = 250 bits (639), Expect = 2e-66
Identities = 192/664 (28%), Positives = 305/664 (45%), Gaps = 70/664 (10%)
Query: 4 YIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKI-KSMERVQGVSITRELLW 62
++Y++P WV+ + MDAL DW +FA+ ++ D T+LR +S +R T +LW
Sbjct: 18 FLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQR------TASVLW 71
Query: 63 WWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRK 122
W R A V LV +L L+L RA II W P P+P+ P + P + +
Sbjct: 72 PWINRNARVADLVHILTHLQLLRARDIITAWHPP----APLPS-PGTTAPRPSSIPAPAE 126
Query: 123 AEDEQEEGQPVRMATFPGPGSSPARAHQ---------PAFLQPPEEDAPHSLRSDLPTSS 173
AE P +TF P ++ H PA L PP S P SS
Sbjct: 127 AEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESS 186
Query: 174 DSKDFSTSIPKQEKLLSLAGDSLF-WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGK 232
S LL A F W ++ + T +F++ KI +G F VYR
Sbjct: 187 VS------------LLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 234
Query: 233 PFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG 292
+ K+L+E A ++++ F E++ R HPN++ G+CA F+ +Y ++ NG
Sbjct: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294
Query: 293 SLQDRLQGQ-GGSDPLPWPQRVSICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTP 349
SL+DRL Q PL WPQR+ I G A+++LH +IH ++KSSNVLLD+ LTP
Sbjct: 295 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP 354
Query: 350 KLAH----PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405
KL + + + +T +R + AYLPE++I+ G+L D FS G+V+
Sbjct: 355 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 414
Query: 406 AEVLTGIPAMDNNRSPV-YLKDLLLSDIPSSTASLCSRKTGVE---------NVMAKEIC 455
E L G A+ + + YLKDL+ + + +L S ++ ++ +A +I
Sbjct: 415 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY 474
Query: 456 QKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGL 515
+K+L+ G P + L AC CL RR + + V R PW L
Sbjct: 475 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQENSYVSSTGRAHSGAAPWQPL 534
Query: 516 SEGTGSSSNTPEETDDVDNSSLDASSS---MSVAPWAGAATPLLPTENGEGRLRVIVGRE 572
+ +G+S+ E+ N +++ S +S A + TP P + LR +
Sbjct: 535 AAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLD--PAPLREAGCPQ 592
Query: 573 ADSSSEACVGLEPPQDVTETSW--------------QIEINEAKRKLMENILLYKEEKVD 618
D++ E+ G P T QI IN A++K+++ + LY++ +D
Sbjct: 593 GDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALD 652
Query: 619 SIEL 622
S++L
Sbjct: 653 SLQL 656
>gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1
[Homo sapiens]
Length = 712
Score = 240 bits (613), Expect = 2e-63
Identities = 196/694 (28%), Positives = 308/694 (44%), Gaps = 100/694 (14%)
Query: 4 YIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKI-KSMERVQGVSITRELLW 62
++Y++P WV+ + MDAL DW +FA+ ++ D T+LR +S +R T +LW
Sbjct: 18 FLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQR------TASVLW 71
Query: 63 WWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRK 122
W R A V LV +L L+L RA II W P P+P+ P + P + +
Sbjct: 72 PWINRNARVADLVHILTHLQLLRARDIITAWHPP----APLPS-PGTTAPRPSSIPAPAE 126
Query: 123 AEDEQEEGQPVRMATFPGPGSSPARAHQ---------PAFLQPPEEDAPHSLRSDLPTSS 173
AE P +TF P ++ H PA L PP S P SS
Sbjct: 127 AEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESS 186
Query: 174 DSKDFSTSIPKQEKLLSLAGDSLF-WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGK 232
S LL A F W ++ + T +F++ KI +G F VYR
Sbjct: 187 VS------------LLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 234
Query: 233 PFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG 292
+ K+L+E A ++++ F E++ R HPN++ G+CA F+ +Y ++ NG
Sbjct: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294
Query: 293 SLQDRLQGQGGS-DPLPWPQRVSICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTP 349
SL+DRL Q + PL WPQR+ I G A+++LH +IH ++KSSNVLLD+ LTP
Sbjct: 295 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP 354
Query: 350 KLAH----PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405
KL + + + +T +R + AYLPE++I+ G+L D FS G+V+
Sbjct: 355 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 414
Query: 406 AEVLTGIPAMDNNRSPV-YLKDLLLSDIPSSTASLCSRKTGVENVMAKE---------IC 455
E L G A+ + + YLKDL+ + + +L S ++ ++ +A + I
Sbjct: 415 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY 474
Query: 456 QKYLEKGAGRLPEDCAEALATAACLCLRRRNT-------------SLQEVCGSVAAVEER 502
+K+L+ G P + L AC CL RR LQ V V E
Sbjct: 475 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEA 534
Query: 503 L-----------------RGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSM-- 543
R PW L+ +G+S+ E+ N +++ S+
Sbjct: 535 ASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGG 594
Query: 544 -SVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSW-------- 594
S A + TP P + LR + D++ E+ G P T
Sbjct: 595 LSAALRSWHLTPSCPLDPAP--LREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSAS 652
Query: 595 ------QIEINEAKRKLMENILLYKEEKVDSIEL 622
QI IN A++K+++ + LY++ +DS++L
Sbjct: 653 SSSEPPQIIINPARQKMVQKLALYEDGALDSLQL 686
>gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3
[Homo sapiens]
Length = 633
Score = 213 bits (543), Expect = 3e-55
Identities = 180/654 (27%), Positives = 281/654 (42%), Gaps = 99/654 (15%)
Query: 4 YIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKI-KSMERVQGVSITRELLW 62
++Y++P WV+ + MDAL DW +FA+ ++ D T+LR +S +R T +LW
Sbjct: 18 FLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQR------TASVLW 71
Query: 63 WWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRK 122
W R A V LV +L L+L RA II W P P+P+ P + P + +
Sbjct: 72 PWINRNARVADLVHILTHLQLLRARDIITAWHPP----APLPS-PGTTAPRPSSIPAPAE 126
Query: 123 AEDEQEEGQPVRMATFPGPGSSPARAHQ---------PAFLQPPEEDAPHSLRSDLPTSS 173
AE P +TF P ++ H PA L PP S P SS
Sbjct: 127 AEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESS 186
Query: 174 DSKDFSTSIPKQEKLLSLAGDSLF-WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGK 232
S LL A F W ++ + T +F++ KI +G F VYR
Sbjct: 187 VS------------LLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 234
Query: 233 PFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG 292
+ K+L+E A ++++ F E++ R HPN++ G+CA F+ +Y ++ NG
Sbjct: 235 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 294
Query: 293 SLQDRLQGQ-GGSDPLPWPQRVSICSGLLCAVEYLH--GLEIIHSNVKSSNVLLDQNLTP 349
SL+DRL Q PL WPQR+ I G A+++LH +IH ++KSSNVLLD+ LTP
Sbjct: 295 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP 354
Query: 350 KLAH----PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405
KL + + + +T +R + AYLPE++I+ G+L D FS G+V+
Sbjct: 355 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 414
Query: 406 AEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGR 465
E L G R K + + LEK
Sbjct: 415 LETLAG-----------------------------QRAVKTHGARTKYLVYERLEKLQAV 445
Query: 466 LPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNT 525
+ + A A+C+ + S G R PW L+ +G+S+
Sbjct: 446 VAGVPGHSEA-ASCIPPSPQENSYVSSTG---------RAHSGAAPWQPLAAPSGASAQA 495
Query: 526 PEETDDVDNSSLDASSS---MSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVG 582
E+ N +++ S +S A + TP P + LR + D++ E+ G
Sbjct: 496 AEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLD--PAPLREAGCPQGDTAGESSWG 553
Query: 583 LEPPQDVTETSW--------------QIEINEAKRKLMENILLYKEEKVDSIEL 622
P T QI IN A++K+++ + LY++ +DS++L
Sbjct: 554 SGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQL 607
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 148 bits (374), Expect = 1e-35
Identities = 116/448 (25%), Positives = 204/448 (45%), Gaps = 71/448 (15%)
Query: 53 GVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKP 112
G S T ELL+ WG TV LVDLL + E + A ++L PD+V P
Sbjct: 63 GKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLL---------------PDAV-P 106
Query: 113 EKPLAASVRKAEDEQEEGQPV--RMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLP 170
+ ++A Q++ P + T P + +++ P P+ +P + ++
Sbjct: 107 KTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMP-----PDSSSPENKSLEV- 160
Query: 171 TSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQN------RKISQGTFADV 224
SD++ S S ++ T++F++ K+ +G F V
Sbjct: 161 --SDTRFHSFSF------------------YELKNVTNNFDERPISVGGNKMGEGGFGVV 200
Query: 225 YRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSF 284
Y+G+ + KKL + +++ F E+++ +C H N++ +LGF +
Sbjct: 201 YKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCL 260
Query: 285 IYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLD 344
+Y YM NGSL DRL G+ PL W R I G + +LH IH ++KS+N+LLD
Sbjct: 261 VYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD 320
Query: 345 QNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIV 404
+ T K++ L +++ T+M + ++ T+A PE G++T + DI+S G+V
Sbjct: 321 EAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITPKSDIYSFGVV 376
Query: 405 LAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAG 464
L E++TG+PA+D +R P L D+ K +E+ ++ + Y++K
Sbjct: 377 LLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKTIEDYIDKKMN 419
Query: 465 RLPEDCAEALATAACLCLRRRNTSLQEV 492
EA+ + A CL + ++
Sbjct: 420 DADSTSVEAMYSVASQCLHEKKNKRPDI 447
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 148 bits (374), Expect = 1e-35
Identities = 116/448 (25%), Positives = 204/448 (45%), Gaps = 71/448 (15%)
Query: 53 GVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKP 112
G S T ELL+ WG TV LVDLL + E + A ++L PD+V P
Sbjct: 63 GKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLL---------------PDAV-P 106
Query: 113 EKPLAASVRKAEDEQEEGQPV--RMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLP 170
+ ++A Q++ P + T P + +++ P P+ +P + ++
Sbjct: 107 KTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMP-----PDSSSPENKSLEV- 160
Query: 171 TSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQN------RKISQGTFADV 224
SD++ S S ++ T++F++ K+ +G F V
Sbjct: 161 --SDTRFHSFSF------------------YELKNVTNNFDERPISVGGNKMGEGGFGVV 200
Query: 225 YRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSF 284
Y+G+ + KKL + +++ F E+++ +C H N++ +LGF +
Sbjct: 201 YKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCL 260
Query: 285 IYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLD 344
+Y YM NGSL DRL G+ PL W R I G + +LH IH ++KS+N+LLD
Sbjct: 261 VYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD 320
Query: 345 QNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIV 404
+ T K++ L +++ T+M + ++ T+A PE G++T + DI+S G+V
Sbjct: 321 EAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITPKSDIYSFGVV 376
Query: 405 LAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAG 464
L E++TG+PA+D +R P L D+ K +E+ ++ + Y++K
Sbjct: 377 LLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKTIEDYIDKKMN 419
Query: 465 RLPEDCAEALATAACLCLRRRNTSLQEV 492
EA+ + A CL + ++
Sbjct: 420 DADSTSVEAMYSVASQCLHEKKNKRPDI 447
>gi|216547519 interleukin-1 receptor-associated kinase 3 isoform a
[Homo sapiens]
Length = 596
Score = 134 bits (337), Expect = 3e-31
Identities = 110/407 (27%), Positives = 182/407 (44%), Gaps = 34/407 (8%)
Query: 202 DVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQIC 261
++++ T +F+++ I +G +VYR + K ++ + F +EL++
Sbjct: 157 NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVL 216
Query: 262 LRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLC 321
L HPN+L + + + IYPYM NG+L DRLQ G + PLPW R+ I G+
Sbjct: 217 LLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISK 276
Query: 322 AVEYLHGLE---IIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRT 377
A+ YLH ++ +I ++ S+N+LLD PKL MAH + T+ T
Sbjct: 277 AIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSK 336
Query: 378 SAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTA 437
Y+PE++IR G+L+ + D++S GIV+ EVLTG + ++ + L+DLL
Sbjct: 337 HLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRE------- 389
Query: 438 SLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRR---NTSLQEVCG 494
K G+++ C +L+K P + + L A C R S+ EV
Sbjct: 390 --LMEKRGLDS------CLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLN 441
Query: 495 SVAAVEERLRGRETLLPWSGLSEGTGSS-------SNTPEETDDVDNSSLDASSSMSVAP 547
++ + + L E P + L S + P E D+ N++L S
Sbjct: 442 TLESTQASLYFAED--PPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRID 499
Query: 548 WAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSW 594
TP +++ L + E+ + EAC P E SW
Sbjct: 500 RMTQKTPFECSQSEVMFLSLDKKPESKRNEEAC---NMPSSSCEESW 543
Score = 43.1 bits (100), Expect = 8e-04
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 5 IYQLPSWVLDDLCRNMDALS-EWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWW 63
++ LP +L +LC +D+ W A + + +R I+ QG S TRELLW
Sbjct: 17 LFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVD-QGKSGTRELLWS 75
Query: 64 WGMRQATVQQLVDLLCRLELYRAAQIILNW 93
W + T+ L+ +L + RA +I N+
Sbjct: 76 WAQKNKTIGDLLQVLQEMGHRRAIHLITNY 105
>gi|216547504 interleukin-1 receptor-associated kinase 3 isoform b
[Homo sapiens]
Length = 535
Score = 134 bits (337), Expect = 3e-31
Identities = 110/407 (27%), Positives = 182/407 (44%), Gaps = 34/407 (8%)
Query: 202 DVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQIC 261
++++ T +F+++ I +G +VYR + K ++ + F +EL++
Sbjct: 96 NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVL 155
Query: 262 LRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLC 321
L HPN+L + + + IYPYM NG+L DRLQ G + PLPW R+ I G+
Sbjct: 156 LLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISK 215
Query: 322 AVEYLHGLE---IIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRT 377
A+ YLH ++ +I ++ S+N+LLD PKL MAH + T+ T
Sbjct: 216 AIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSK 275
Query: 378 SAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTA 437
Y+PE++IR G+L+ + D++S GIV+ EVLTG + ++ + L+DLL
Sbjct: 276 HLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRE------- 328
Query: 438 SLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRR---NTSLQEVCG 494
K G+++ C +L+K P + + L A C R S+ EV
Sbjct: 329 --LMEKRGLDS------CLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLN 380
Query: 495 SVAAVEERLRGRETLLPWSGLSEGTGSS-------SNTPEETDDVDNSSLDASSSMSVAP 547
++ + + L E P + L S + P E D+ N++L S
Sbjct: 381 TLESTQASLYFAED--PPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRID 438
Query: 548 WAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSW 594
TP +++ L + E+ + EAC P E SW
Sbjct: 439 RMTQKTPFECSQSEVMFLSLDKKPESKRNEEAC---NMPSSSCEESW 482
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 134 bits (336), Expect = 3e-31
Identities = 80/278 (28%), Positives = 139/278 (50%), Gaps = 21/278 (7%)
Query: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
K+ +G F VY+G+ + KKL + +++ F E+++ +C H N++ +LG
Sbjct: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
Query: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
F + +Y YM NGSL DRL G+ PL W R I G + +LH IH
Sbjct: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
Query: 335 NVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTK 394
++KS+N+LLD+ T K++ L +++ T+M + ++ T+A PE G++T
Sbjct: 187 DIKSANILLDEAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITP 242
Query: 395 RVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEI 454
+ DI+S G+VL E++TG+PA+D +R P L D+ K +E+ ++
Sbjct: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKT 285
Query: 455 CQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEV 492
+ Y++K EA+ + A CL + ++
Sbjct: 286 IEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDI 323
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 134 bits (336), Expect = 3e-31
Identities = 80/278 (28%), Positives = 139/278 (50%), Gaps = 21/278 (7%)
Query: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
K+ +G F VY+G+ + KKL + +++ F E+++ +C H N++ +LG
Sbjct: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
Query: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
F + +Y YM NGSL DRL G+ PL W R I G + +LH IH
Sbjct: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
Query: 335 NVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTK 394
++KS+N+LLD+ T K++ L +++ T+M + ++ T+A PE G++T
Sbjct: 187 DIKSANILLDEAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITP 242
Query: 395 RVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEI 454
+ DI+S G+VL E++TG+PA+D +R P L D+ K +E+ ++
Sbjct: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKT 285
Query: 455 CQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEV 492
+ Y++K EA+ + A CL + ++
Sbjct: 286 IEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDI 323
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 134 bits (336), Expect = 3e-31
Identities = 80/278 (28%), Positives = 139/278 (50%), Gaps = 21/278 (7%)
Query: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
K+ +G F VY+G+ + KKL + +++ F E+++ +C H N++ +LG
Sbjct: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
Query: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
F + +Y YM NGSL DRL G+ PL W R I G + +LH IH
Sbjct: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
Query: 335 NVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTK 394
++KS+N+LLD+ T K++ L +++ T+M + ++ T+A PE G++T
Sbjct: 187 DIKSANILLDEAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITP 242
Query: 395 RVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEI 454
+ DI+S G+VL E++TG+PA+D +R P L D+ K +E+ ++
Sbjct: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKT 285
Query: 455 CQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEV 492
+ Y++K EA+ + A CL + ++
Sbjct: 286 IEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDI 323
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 74.7 bits (182), Expect = 2e-13
Identities = 59/214 (27%), Positives = 101/214 (47%), Gaps = 19/214 (8%)
Query: 208 DDFNQNRKISQGTFADVYR-GHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCH 266
DDF+ KI G F++VY+ HR + K+ + + ++ E+Q+ R H
Sbjct: 55 DDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLR-----EVQLMNRLRH 109
Query: 267 PNVLPVLGFCAAR-QFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEY 325
PN+L +G C + Q H+ + YM G+L+ L +PL WP R+ + + + Y
Sbjct: 110 PNILRFMGVCVHQGQLHA-LTEYMNGGTLEQLLSSP---EPLSWPVRLHLALDIARGLRY 165
Query: 326 LHGLEIIHSNVKSSNVLL---DQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
LH + H ++ S N L+ D+ T + +A PV + K L + Y
Sbjct: 166 LHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREG---ARKEPLAVVGSPY 222
Query: 382 LPEDFIRVGQL-TKRVDIFSCGIVLAEVLTGIPA 414
+ G+L ++ D+F+ GIVL E++ +PA
Sbjct: 223 WMAPEVLRGELYDEKADVFAFGIVLCELIARVPA 256
>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
Length = 686
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/194 (27%), Positives = 87/194 (44%), Gaps = 22/194 (11%)
Query: 231 GKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMA 290
GK V K+L C ++ F E+++ HPNVL +G + + + Y+
Sbjct: 333 GKVMVMKEL--IRCDE--ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIE 388
Query: 291 NGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPK 350
G+L+D L+ DP PW Q+V G+ + YLH + IIH ++ S N L+ + T
Sbjct: 389 GGTLKDFLRSM---DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVV 445
Query: 351 LAHPMAHLCPVNKRSKYTMMK-THLLRT--------------SAAYLPEDFIRVGQLTKR 395
+A V +R + M K T RT + ++ + + +
Sbjct: 446 VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDET 505
Query: 396 VDIFSCGIVLAEVL 409
VDIFS GIVL E++
Sbjct: 506 VDIFSFGIVLCEII 519
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/194 (27%), Positives = 87/194 (44%), Gaps = 22/194 (11%)
Query: 231 GKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMA 290
GK V K+L C ++ F E+++ HPNVL +G + + + Y+
Sbjct: 333 GKVMVMKEL--IRCDE--ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIE 388
Query: 291 NGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPK 350
G+L+D L+ DP PW Q+V G+ + YLH + IIH ++ S N L+ + T
Sbjct: 389 GGTLKDFLRSM---DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVV 445
Query: 351 LAHPMAHLCPVNKRSKYTMMK-THLLRT--------------SAAYLPEDFIRVGQLTKR 395
+A V +R + M K T RT + ++ + + +
Sbjct: 446 VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDET 505
Query: 396 VDIFSCGIVLAEVL 409
VDIFS GIVL E++
Sbjct: 506 VDIFSFGIVLCEII 519
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/194 (27%), Positives = 87/194 (44%), Gaps = 22/194 (11%)
Query: 231 GKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMA 290
GK V K+L C ++ F E+++ HPNVL +G + + + Y+
Sbjct: 354 GKVMVMKEL--IRCDE--ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIE 409
Query: 291 NGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPK 350
G+L+D L+ DP PW Q+V G+ + YLH + IIH ++ S N L+ + T
Sbjct: 410 GGTLKDFLRSM---DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVV 466
Query: 351 LAHPMAHLCPVNKRSKYTMMK-THLLRT--------------SAAYLPEDFIRVGQLTKR 395
+A V +R + M K T RT + ++ + + +
Sbjct: 467 VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDET 526
Query: 396 VDIFSCGIVLAEVL 409
VDIFS GIVL E++
Sbjct: 527 VDIFSFGIVLCEII 540
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/184 (29%), Positives = 88/184 (47%), Gaps = 18/184 (9%)
Query: 251 ERFFQAELQICLRCC-HPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPW 309
+R F E+++ +RC HPNVL +G + +FI Y+ G+L+ ++ PW
Sbjct: 378 QRTFLKEVKV-MRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ--YPW 434
Query: 310 PQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLA-HPMAHLC------PVN 362
QRVS + + YLH + IIH ++ S N L+ +N +A +A L P
Sbjct: 435 SQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEG 494
Query: 363 KRS--KYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS 420
RS K K + + + ++ + I ++VD+FS GIVL E++ + N
Sbjct: 495 LRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV-----NAD 549
Query: 421 PVYL 424
P YL
Sbjct: 550 PDYL 553
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 66.6 bits (161), Expect = 6e-11
Identities = 48/181 (26%), Positives = 83/181 (45%), Gaps = 21/181 (11%)
Query: 257 ELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSIC 316
E +I + +LP+LG C +F + YM NGSL + L + + WP R I
Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125
Query: 317 SGLLCAVEYLHGL--EIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHL 374
+ V YLH + ++H ++K+ N+LLD K+A SK+ MM
Sbjct: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIAD--------FGLSKWRMMSLSQ 177
Query: 375 LRTSAA--------YLPEDFIRVGQLTK---RVDIFSCGIVLAEVLTGIPAMDNNRSPVY 423
R+S + Y+P + GQ ++ + DI+S ++ EVL+ ++ +P+
Sbjct: 178 SRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQ 237
Query: 424 L 424
+
Sbjct: 238 I 238
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/212 (26%), Positives = 92/212 (43%), Gaps = 13/212 (6%)
Query: 208 DDFNQNRKISQGTFADVYRGHRHGKPFV--FKKLRETACSSPGSIERFFQAELQICLRCC 265
DDF R + +G F +VY F+ K L ++ G +E + E++I
Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG-VEHQLRREIEIQAHLH 133
Query: 266 HPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEY 325
HPN+L + + R+ I Y G L LQ D + +I L A+ Y
Sbjct: 134 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDE---QRTATIMEELADALMY 190
Query: 326 LHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPED 385
HG ++IH ++K N+LL K+A + + R K TM T YLP +
Sbjct: 191 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRK-TMCGT------LDYLPPE 243
Query: 386 FIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDN 417
I ++VD++ G++ E+L G P ++
Sbjct: 244 MIEGRMHNEKVDLWCIGVLCYELLVGNPPFES 275
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 17/277 (6%)
Query: 148 AHQPAFLQPPEE----DAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADV 203
+H+P Q ++ PH + L + SK S P+ LA
Sbjct: 67 SHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKR 126
Query: 204 VQATDDFNQNRKISQGTFADVYRGHRHGKPFVFK-KLRETACSSPGSIERFFQAELQICL 262
A +DF R + +G F +VY F+ K+ A +E + E++I
Sbjct: 127 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 186
Query: 263 RCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCA 322
HPN+L + G+ I Y G++ LQ D + + + L A
Sbjct: 187 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 243
Query: 323 VEYLHGLEIIHSNVKSSNVLLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAY 381
+ Y H +IH ++K N+LL K+A + P ++R+ L + Y
Sbjct: 244 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT--------LCGTLDY 295
Query: 382 LPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN 418
LP + I ++VD++S G++ E L G P + N
Sbjct: 296 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 63.9 bits (154), Expect = 4e-10
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 21/208 (10%)
Query: 216 ISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGF 275
+ G V+ G HG+ KK+R+ + +++ + HPN++ G
Sbjct: 131 VGSGAQGAVFLGRFHGEEVAVKKVRDLK-----------ETDIKHLRKLKHPNIITFKGV 179
Query: 276 CAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSN 335
C + + + A G L + L+ P+ V G+ + YLH +IIH +
Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRA---GRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD 236
Query: 336 VKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKR 395
+KS N+L+ + K++ +K +K + T A++ + IR ++++
Sbjct: 237 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT------VAWMAPEVIRNEPVSEK 290
Query: 396 VDIFSCGIVLAEVLTG-IPAMDNNRSPV 422
VDI+S G+VL E+LTG IP D + S +
Sbjct: 291 VDIWSFGVVLWELLTGEIPYKDVDSSAI 318
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 63.5 bits (153), Expect = 5e-10
Identities = 54/197 (27%), Positives = 98/197 (49%), Gaps = 12/197 (6%)
Query: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
K+ QG F +V+ G +G V K + SP E F Q E Q+ + H ++ +
Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQ-EAQVMKKLRHEKLVQLYA 330
Query: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
+ + + YM+ GSL D L+G+ G L PQ V + + + + Y+ + +H
Sbjct: 331 VVSEEPIY-IVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388
Query: 335 NVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLT 393
+++++N+L+ +NL K+A +A L N+ + K + T+ PE + G+ T
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA----PEAAL-YGRFT 443
Query: 394 KRVDIFSCGIVLAEVLT 410
+ D++S GI+L E+ T
Sbjct: 444 IKSDVWSFGILLTELTT 460
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 63.5 bits (153), Expect = 5e-10
Identities = 54/197 (27%), Positives = 98/197 (49%), Gaps = 12/197 (6%)
Query: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
K+ QG F +V+ G +G V K + SP E F Q E Q+ + H ++ +
Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQ-EAQVMKKLRHEKLVQLYA 330
Query: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
+ + + YM+ GSL D L+G+ G L PQ V + + + + Y+ + +H
Sbjct: 331 VVSEEPIY-IVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388
Query: 335 NVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLT 393
+++++N+L+ +NL K+A +A L N+ + K + T+ PE + G+ T
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA----PEAAL-YGRFT 443
Query: 394 KRVDIFSCGIVLAEVLT 410
+ D++S GI+L E+ T
Sbjct: 444 IKSDVWSFGILLTELTT 460
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 13/227 (5%)
Query: 208 DDFNQNRKISQGTFADVYRGHRHGKPFV--FKKLRETACSSPGSIERFFQAELQICLRCC 265
DDF R + +G F +VY F+ K L ++ G +E + E++I
Sbjct: 7 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEG-LEHQLRREIEIQAHLQ 65
Query: 266 HPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEY 325
HPN+L + + + I Y G L LQ S+ L + +I L A+ Y
Sbjct: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQK---SEKLDEQRTATIIEELADALTY 122
Query: 326 LHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPED 385
H ++IH ++K N+LL K+A + + R K TM T YLP +
Sbjct: 123 CHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK-TMCGT------LDYLPPE 175
Query: 386 FIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDI 432
I ++VD++ G++ E+L G P ++ + +L D+
Sbjct: 176 MIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDV 222
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 13/227 (5%)
Query: 208 DDFNQNRKISQGTFADVYRGHRHGKPFV--FKKLRETACSSPGSIERFFQAELQICLRCC 265
DDF R + +G F +VY F+ K L ++ G +E + E++I
Sbjct: 22 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEG-LEHQLRREIEIQAHLQ 80
Query: 266 HPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEY 325
HPN+L + + + I Y G L LQ S+ L + +I L A+ Y
Sbjct: 81 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQK---SEKLDEQRTATIIEELADALTY 137
Query: 326 LHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPED 385
H ++IH ++K N+LL K+A + + R K TM T YLP +
Sbjct: 138 CHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK-TMCGT------LDYLPPE 190
Query: 386 FIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDI 432
I ++VD++ G++ E+L G P ++ + +L D+
Sbjct: 191 MIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDV 237
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 13/227 (5%)
Query: 208 DDFNQNRKISQGTFADVYRGHRHGKPFV--FKKLRETACSSPGSIERFFQAELQICLRCC 265
DDF R + +G F +VY F+ K L ++ G +E + E++I
Sbjct: 41 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEG-LEHQLRREIEIQAHLQ 99
Query: 266 HPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEY 325
HPN+L + + + I Y G L LQ S+ L + +I L A+ Y
Sbjct: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQK---SEKLDEQRTATIIEELADALTY 156
Query: 326 LHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPED 385
H ++IH ++K N+LL K+A + + R K TM T YLP +
Sbjct: 157 CHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRK-TMCGT------LDYLPPE 209
Query: 386 FIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDI 432
I ++VD++ G++ E+L G P ++ + +L D+
Sbjct: 210 MIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDV 256
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,749,731
Number of Sequences: 37866
Number of extensions: 1270115
Number of successful extensions: 6388
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 231
Number of HSP's successfully gapped in prelim test: 458
Number of HSP's that attempted gapping in prelim test: 5444
Number of HSP's gapped (non-prelim): 941
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.