Search of human proteins with 58331148

Search of human proteins with 58331148

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
sapiens]
         (488 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...  1036   0.0  
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   312   5e-85
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   303   2e-82
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   300   2e-81
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   295   8e-80
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   290   2e-78
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   280   2e-75
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    256   2e-68
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   248   9e-66
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      248   1e-65
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   248   1e-65
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   232   7e-61
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   231   1e-60
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    226   3e-59
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   224   2e-58
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   223   4e-58
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   214   1e-55
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                214   1e-55
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   211   2e-54
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      170   3e-42
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   170   3e-42
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   156   4e-38
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   148   1e-35
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    144   1e-34
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   129   6e-30
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      125   1e-28
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    71   3e-12
gi|88853069 vitronectin precursor [Homo sapiens]                       67   4e-11
gi|11321561 hemopexin precursor [Homo sapiens]                         65   1e-10
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           63   7e-10

>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score = 1036 bits (2679), Expect = 0.0
 Identities = 488/488 (100%), Positives = 488/488 (100%)

Query: 1   MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPA 60
           MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPA
Sbjct: 1   MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPA 60

Query: 61  PAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ 120
           PAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ
Sbjct: 61  PAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ 120

Query: 121 LVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHA 180
           LVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHA
Sbjct: 121 LVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHA 180

Query: 181 FFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR 240
           FFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR
Sbjct: 181 FFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR 240

Query: 241 YPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDA 300
           YPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDA
Sbjct: 241 YPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDA 300

Query: 301 VSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGA 360
           VSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGA
Sbjct: 301 VSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGA 360

Query: 361 QYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
           QYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS
Sbjct: 361 QYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420

Query: 421 PVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
           PVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC
Sbjct: 421 PVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480

Query: 481 AEPANTFL 488
           AEPANTFL
Sbjct: 481 AEPANTFL 488


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  312 bits (799), Expect = 5e-85
 Identities = 177/438 (40%), Positives = 239/438 (54%), Gaps = 34/438 (7%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           ++ PRCGVPD    LS R R KR+ L+G +W +  +TY I  +  ++ +   R+ + +A 
Sbjct: 134 MKKPRCGVPDHPH-LSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAF 192

Query: 135 KVWSDVTPLTFTEV--HEGR-----ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHR 187
            VW  VTPLTF EV  HE +     ADIMI FA  +HGD  PFDG GG LAHA+FP    
Sbjct: 193 DVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGI 252

Query: 188 EGDVHFDYDETWTIGD--DQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPL 243
            GD HFD DE WT+G+    G DL  VA HE GH LGL+H++   A+M+ FY +   +  
Sbjct: 253 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNF 312

Query: 244 SLSPDDCRGVQHLYG---------QPWPTV--------TSRTPALGPQAGIDTNEIAPLE 286
            L  DD +G+Q +YG         +P PT+        + R     P+         P  
Sbjct: 313 KLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372

Query: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346
           P   P+ C+ +F+ V+  RGE+F FK  + WRLR  ++Q GYP    + W+GLP+ +DAA
Sbjct: 373 PGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAA 432

Query: 347 FEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELG--LVRFPVHAALVWGPEKNKIYFF 403
           +E A G   FF+G +YWV+       G P  L ELG  L R  +  AL W P   K YFF
Sbjct: 433 YERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEP-VGKTYFF 491

Query: 404 RGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVK 462
           +G  YWR+    R  D   P+  T W+G+P     AF   +G Y YF +GR YWKFD  K
Sbjct: 492 KGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQK 551

Query: 463 VKALEGFPRLVGPDFFGC 480
           +    G+PR +  D+ GC
Sbjct: 552 LSVEPGYPRNILRDWMGC 569


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  303 bits (776), Expect = 2e-82
 Identities = 202/516 (39%), Positives = 258/516 (50%), Gaps = 49/516 (9%)

Query: 13  RALLPPMLLLLLQPPPLLARALPPDA-------------------HHLHAERRGPQPWHA 53
           R  L  +LLLLL PP   ARA  P A                   H   A+ + P+    
Sbjct: 4   RLRLLALLLLLLAPP---ARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD 60

Query: 54  ALPSSP--APAPATQEA-PRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDL 110
           A+      A  P T    P   +++R PRC +PD         R++R+ LSG  W+K  L
Sbjct: 61  AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL 120

Query: 111 TYRILRFPW--QLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRA---DIMIDFARYWHG 165
           T+R+  FP   QL QE VR  M+ AL  W   + LTF EV   +    DI+IDFAR +H 
Sbjct: 121 TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ 180

Query: 166 DDLPFDGPGGILAHAFFPKTHR-EGDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLG 222
           D  PFDG GG LAHAFFP  H   GD HFD +ETWT G  D +GTDL  VA HEFGH LG
Sbjct: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240

Query: 223 LQHTTAAKALMSAFYTFRYPLS------LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
           L H++A  ++M  FY  + P+       LS DD  G+Q LYG+  P      P   P A 
Sbjct: 241 LGHSSAPNSIMRPFY--QGPVGDPDKYRLSQDDRDGLQQLYGKA-PQTPYDKPTRKPLAP 297

Query: 277 IDTNEIAPLE-PDAP-PDACEASFDAVSTIRGELFFFKAGFVWRLR-GGQLQPGYPALAS 333
                 +P   P  P PD CE +FDA++ IRGE FFFK  + WRL+  GQL    PA   
Sbjct: 298 PPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLH 357

Query: 334 RHWQGLPSPV---DAAF-EDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHA 389
           R W+GLP+ V    AA+     G I  F G Q+WV+   +   G  PLTELGL       
Sbjct: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVD 417

Query: 390 ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYF 449
           A+   P+  K Y  RGR YWR+  +  R D   PR  + W G P   D       G  YF
Sbjct: 418 AVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYF 477

Query: 450 LRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPAN 485
            +G  YW+F    +K     P+ +GP++  C  P++
Sbjct: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSS 513


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  300 bits (769), Expect = 2e-81
 Identities = 173/469 (36%), Positives = 249/469 (53%), Gaps = 27/469 (5%)

Query: 34  LPPDAHHLHAERRGPQPWHAALPSSPA--PAPATQEAPRPA-SSLRPPRCGVPDPSDG-L 89
           LPP     H +R  PQ   AA+ +         T +A      ++R PRCGVPD     +
Sbjct: 45  LPPGDLRTHTQR-SPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEI 103

Query: 90  SARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEV- 148
            A  R+KR+ + G +W+  ++T+ I  +  ++ +    + + +A +VW   TPL F EV 
Sbjct: 104 KANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVP 163

Query: 149 -------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTI 201
                  HE +ADIMI FA  +HGD  PFDG GG LAHA+FP  +  GD HFD  E WT+
Sbjct: 164 YAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223

Query: 202 GDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LSPDDCRGVQHLY 257
            ++   G D+  VA HE GH LGL+H++   A+M+ FY +    +  L  DD RG+Q LY
Sbjct: 224 RNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLY 283

Query: 258 G--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGF 315
           G    +PT     P    +  +      P  P   P+ C+ +FD V+ +RGE+F FK  +
Sbjct: 284 GGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAMLRGEMFVFKERW 340

Query: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-P 374
            WR+R  Q+  GYP    + W+GLP+ ++ A+E   G   FF+G ++WV+D      G P
Sbjct: 341 FWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYP 400

Query: 375 APLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGV 432
             + EL  GL    + AAL W P   K YFFRG  Y+RF+   R VDS  P+    W G+
Sbjct: 401 KHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGI 459

Query: 433 PSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
           P     +F  +D  + YF +G  YWKF+  K+K   G+P+    D+ GC
Sbjct: 460 PESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)

Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
           +F+K    W+    +L  +PGYP  A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  295 bits (754), Expect = 8e-80
 Identities = 163/443 (36%), Positives = 235/443 (53%), Gaps = 33/443 (7%)

Query: 75  LRPPRCGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133
           ++ PRCGVPD + G S  + R+KR+ L+G +W+   +TY I     ++   + R+ +  A
Sbjct: 96  MKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRA 155

Query: 134 LKVWSDVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTH 186
             VW +VTPLTF EV       G+   DI I FA  +HGD  PFDG GG LAHA+FP   
Sbjct: 156 FDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG 215

Query: 187 REGDVHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP-- 242
             GD HFD DE WT+G+    G DL  VA HE GH LGL+H+    A+M+ FY +     
Sbjct: 216 IGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDN 275

Query: 243 LSLSPDDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLE 286
             L  DD +G+Q +YG P   P  T   P + P   I   +                P  
Sbjct: 276 FKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335

Query: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346
           P A P+ C+ +F+ ++ +R E+F FK  + WR+R  ++  GYP   +  W+GLP  +DA 
Sbjct: 336 PGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAV 395

Query: 347 FEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFF 403
           +E++ G+  FF+G +YWV+       G P  L  LG    P H   + +W  +  K YFF
Sbjct: 396 YENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-SGIPPHGIDSAIWWEDVGKTYFF 454

Query: 404 RGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVK 462
           +G  YWR+    + +D   P+  T W+G+P     AF    +G+ YF +G+ YWKF+   
Sbjct: 455 KGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQI 514

Query: 463 VKALEGFPRLVGPDFFGCAEPAN 485
           +K   G+PR +  DF GC  P +
Sbjct: 515 LKVEPGYPRSILKDFMGCDGPTD 537


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  290 bits (742), Expect = 2e-78
 Identities = 186/541 (34%), Positives = 256/541 (47%), Gaps = 66/541 (12%)

Query: 8   RSAAARALLPPMLLLLLQPPPLLARALPPDAH-----HLHAERRGPQPWHAALPSSPAPA 62
           R  AAR  L P+LL+LL    L   A   + H      L+     P    + + S+   A
Sbjct: 21  REEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILA 80

Query: 63  PATQEAPR----PASS---------LRPPRCGVPDPSD---GLSARNRQKRFVLSGGRWE 106
            A  E  R    P +          ++ PRCGVPD        + R R+KR+ L+G +W 
Sbjct: 81  SALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWN 140

Query: 107 KTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEV--------HEGRADIMID 158
              LT+ I  +  +L      + +  A +VW   TPL F EV         +  ADIM+ 
Sbjct: 141 NHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVL 200

Query: 159 FARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIG--DDQGTDLLQVAAHE 216
           FA  +HGD  PFDG GG LAHA+FP     GD HFD DE WT    D  G +L  VA HE
Sbjct: 201 FASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHE 260

Query: 217 FGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDCRGVQHLYG---------QPWPTVT 265
            GH LGL+H++   A+M+ FY ++      L  DD RG+Q LYG         QP PTVT
Sbjct: 261 LGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVT 320

Query: 266 SRTPALG--------------------PQAGIDTNEIAPLEPDA-PPDACEASFDAVSTI 304
            R P                       P+ G      A   PD   P+ C+  FD V+ +
Sbjct: 321 PRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAML 380

Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
           RGE+F FK  + WR+R  ++   YP      W+GLP  + AA+E   G   FF+G +YW+
Sbjct: 381 RGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWL 440

Query: 365 YDGEKPVLG-PAPLTELGL-VRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
           +       G P PLT  GL + +      +W       +FF+   YWRF+  T+R D   
Sbjct: 441 FREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGY 500

Query: 423 PRRATDWRGVPSEIDAAFQDAD-GYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCA 481
           P+  + W+G+P+    AF   D  Y YF +G  YWKFD  +++   G+P+ +  DF GC 
Sbjct: 501 PKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQ 560

Query: 482 E 482
           E
Sbjct: 561 E 561


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  280 bits (716), Expect = 2e-75
 Identities = 172/428 (40%), Positives = 225/428 (52%), Gaps = 27/428 (6%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAE 132
           ++ PRC +PD      AR R++    +  +W K +L++R+  FP    L  + VR  M  
Sbjct: 105 MKTPRCSLPDLPVLTQARRRRQ--APAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYY 162

Query: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFP-KTHREGDV 191
           ALKVWSD+ PL F EV    ADI IDF++  H D  PFDGPGG +AHAFFP   H  GD 
Sbjct: 163 ALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDT 222

Query: 192 HFDYDETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY------TFRYPL 243
           HFD DE WT    D  G DL  VA HEFGH +GL H  AA ++M  +Y        RY  
Sbjct: 223 HFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRY-- 280

Query: 244 SLSPDDCRGVQHLYG---QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDA 300
            L  +D   V  LYG      PT     P L P+   D    AP   D  P  C   FDA
Sbjct: 281 GLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPP-DNRSSAPPRKDV-PHRCSTHFDA 338

Query: 301 VSTIRGELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDAQGH-IW 355
           V+ IRGE FFFK  + WRL R   L    PA   R W+GLP     VDA +E    H I 
Sbjct: 339 VAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIV 398

Query: 356 FFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPS 414
           FF+G +YWV+       G P P+++  L    + AA  W    ++ YFF+ + YWR+   
Sbjct: 399 FFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWA-HNDRTYFFKDQLYWRYDDH 457

Query: 415 TRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVG 474
           TR +D   P ++  WRGVPS +D A + +DG +YF RG+ YWK    +++   G+P+   
Sbjct: 458 TRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTA 517

Query: 475 PDFFGCAE 482
            D+  C +
Sbjct: 518 RDWLVCGD 525


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  256 bits (655), Expect = 2e-68
 Identities = 165/397 (41%), Positives = 213/397 (53%), Gaps = 34/397 (8%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           +R PRCGVPD     +     K        W KT LTYRI+ +   L ++ V   + +AL
Sbjct: 87  MRKPRCGVPDVGHFRTFPGIPK--------WRKTHLTYRIVNYTPDLPKDAVDSAVEKAL 138

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
           KVW +VTPLTF+ ++EG ADIMI FA   HGD  PFDGPG +LAHA+ P     GD HFD
Sbjct: 139 KVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFD 198

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCR 251
            DE WT  D  GT+L  VAAHE GH LGL H+   +ALM   Y     L+   LS DD  
Sbjct: 199 DDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDIN 257

Query: 252 GVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA-SFDAVSTIRGELFF 310
           G+Q LYG P  +         P+  +   E  P EP  P +   A SFDAVST+RGE+  
Sbjct: 258 GIQSLYGPPPDS---------PETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILI 308

Query: 311 FKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEK 369
           FK    WR    +L+P    L S  W  LPS VDAA+E  ++  ++ F+G Q+W   G +
Sbjct: 309 FKDRHFWRKSLRKLEPEL-HLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNE 367

Query: 370 PVLG-PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPR 424
              G P  +  LG   FP       A +   EKNK YFF    YWRF      ++   P+
Sbjct: 368 VRAGYPRGIHTLG---FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPK 424

Query: 425 R-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
           + A D+ G+ S+IDA F++  G+ YF  G    +FDP
Sbjct: 425 QIAEDFPGIDSKIDAVFEEF-GFFYFFTGSSQLEFDP 460


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  248 bits (633), Expect = 9e-66
 Identities = 161/396 (40%), Positives = 210/396 (53%), Gaps = 32/396 (8%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           +R PRCGVPD     S     K        W KT LTYRI+ +   L ++ V   + +AL
Sbjct: 86  MRKPRCGVPDVGHFSSFPGMPK--------WRKTHLTYRIVNYTPDLPRDAVDSAIEKAL 137

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
           KVW +VTPLTF+ ++EG ADIMI FA   HGD   FDGPG  LAHA+ P     GD+HFD
Sbjct: 138 KVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFD 197

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCR 251
            DE WT  D  GT+L  VAAHE GH LGL H+   +ALM   Y     L+   LS DD  
Sbjct: 198 DDEKWT-EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVN 256

Query: 252 GVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFF 311
           G+Q LYG   P   S    L P   + +    P + D        SFDA+ST+RGE  FF
Sbjct: 257 GIQSLYG---PPPASTEEPLVPTKSVPSGSEMPAKCDP-----ALSFDAISTLRGEYLFF 308

Query: 312 KAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKP 370
           K  + WR      +P +  L S  W  LPS +DAA+E +++  ++ F+G ++W   G + 
Sbjct: 309 KDRYFWRRSHWNPEPEF-HLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEV 367

Query: 371 VLG-PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR 425
             G P  +  LG   FP       A V   EK K YFF    YWRF  +++ ++   PR 
Sbjct: 368 QAGYPRGIHTLG---FPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424

Query: 426 -ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
            A D+ GV  ++DA  Q A G+ YF  G   ++FDP
Sbjct: 425 IADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQFEFDP 459


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  248 bits (632), Expect = 1e-65
 Identities = 159/399 (39%), Positives = 215/399 (53%), Gaps = 49/399 (12%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132
           ++ PRCGVPD +          +FVL+ G  RWE+T LTYRI  +   L +  V   + +
Sbjct: 21  MKQPRCGVPDVA----------QFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEK 70

Query: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
           A ++WS+VTPLTFT+V EG+ADIMI F R  H D+ PFDGPGG LAHAF P     GD H
Sbjct: 71  AFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAH 130

Query: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRG 252
           FD DE WT  + +  +L +VAAHE GH LGL H+T   ALM   YTF   + L+ DD  G
Sbjct: 131 FDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDG 189

Query: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA--SFDAVSTIRGELFF 310
           +Q +YG+                    N + P+ P   P AC++  +FDA++TIRGE+ F
Sbjct: 190 IQAIYGR------------------SQNPVQPIGPQT-PKACDSKLTFDAITTIRGEVMF 230

Query: 311 FKAGFVWRLRGGQLQPGYPAL----ASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVY 365
           FK  F  R       P YP +     S  W  LP+ ++AA+E A +  + FF+G +YW  
Sbjct: 231 FKDRFYMR-----TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAV 285

Query: 366 DGEKPVLG-PAPL-TELGLVRFPVHAALVWGPEK-NKIYFFRGRDYWRFHPSTRRVDSPV 422
            G+  + G P  + +  G  R   H       E   K YFF    YWR+    R +D   
Sbjct: 286 QGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGY 345

Query: 423 PRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
           P+  A D+ G+  ++DA F   DG+ YF  G   +KFDP
Sbjct: 346 PKMIAHDFPGIGHKVDAVFM-KDGFFYFFHGTRQYKFDP 383


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  248 bits (632), Expect = 1e-65
 Identities = 159/399 (39%), Positives = 215/399 (53%), Gaps = 49/399 (12%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132
           ++ PRCGVPD +          +FVL+ G  RWE+T LTYRI  +   L +  V   + +
Sbjct: 87  MKQPRCGVPDVA----------QFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEK 136

Query: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
           A ++WS+VTPLTFT+V EG+ADIMI F R  H D+ PFDGPGG LAHAF P     GD H
Sbjct: 137 AFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAH 196

Query: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRG 252
           FD DE WT  + +  +L +VAAHE GH LGL H+T   ALM   YTF   + L+ DD  G
Sbjct: 197 FDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDG 255

Query: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA--SFDAVSTIRGELFF 310
           +Q +YG+                    N + P+ P   P AC++  +FDA++TIRGE+ F
Sbjct: 256 IQAIYGR------------------SQNPVQPIGPQT-PKACDSKLTFDAITTIRGEVMF 296

Query: 311 FKAGFVWRLRGGQLQPGYPAL----ASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVY 365
           FK  F  R       P YP +     S  W  LP+ ++AA+E A +  + FF+G +YW  
Sbjct: 297 FKDRFYMR-----TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAV 351

Query: 366 DGEKPVLG-PAPL-TELGLVRFPVHAALVWGPEK-NKIYFFRGRDYWRFHPSTRRVDSPV 422
            G+  + G P  + +  G  R   H       E   K YFF    YWR+    R +D   
Sbjct: 352 QGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGY 411

Query: 423 PRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
           P+  A D+ G+  ++DA F   DG+ YF  G   +KFDP
Sbjct: 412 PKMIAHDFPGIGHKVDAVFM-KDGFFYFFHGTRQYKFDP 449


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  232 bits (591), Expect = 7e-61
 Identities = 147/392 (37%), Positives = 205/392 (52%), Gaps = 38/392 (9%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           ++ PRCGVPD  +     N   R +    +W K +LTYRI+ +   +   +V +   +A 
Sbjct: 91  MKKPRCGVPDVGE----YNVFPRTL----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAF 142

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
           KVWSDVTPL FT +H+G ADIMI F    HGD  PFDGP G+LAHAF P  +  GD HFD
Sbjct: 143 KVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTF--RYPLSLSPDDCRG 252
            DETWT    +G +L  VAAHEFGH LGL H+    ALM   YT+  +    L  DD +G
Sbjct: 203 DDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQG 261

Query: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACE--ASFDAVSTIRGELFF 310
           +Q LYG                   D N   P  P   PD C+   S DA++++RGE   
Sbjct: 262 IQSLYG---------------PGDEDPN---PKHPKT-PDKCDPSLSLDAITSLRGETMI 302

Query: 311 FKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEK 369
           FK  F WRL   Q+      L    W  LP+ +DAA+E  +   I+ F+G ++W  +G  
Sbjct: 303 FKDRFFWRLHPQQVDAEL-FLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYD 361

Query: 370 PVLG-PAPLTELGLVR-FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-A 426
            + G P  ++ELGL +     +A V   +  K   F G   WR+  +   +D   PR   
Sbjct: 362 ILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIE 421

Query: 427 TDWRGVPSEIDAAFQDADGYAYFLRGRLYWKF 458
            D+ G+  ++DA + + +GY YF  G + +++
Sbjct: 422 EDFPGIGDKVDAVY-EKNGYIYFFNGPIQFEY 452


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  231 bits (588), Expect = 1e-60
 Identities = 148/411 (36%), Positives = 209/411 (50%), Gaps = 23/411 (5%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           +R PRCG+ DP       N++    L  GRW K  LT+RIL  P  L     R  + +A 
Sbjct: 80  MRQPRCGLEDPF------NQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAF 133

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDF-ARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHF 193
           + WS+V PLTF EV  G ADI + F  R        FDGPG +LAHA  P+    G VHF
Sbjct: 134 QDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPEL---GSVHF 190

Query: 194 DYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYT-FRYPLSLSPDDCRG 252
           D DE WT G  +G +L  +AAHE GH LGL H+  ++ALM+  Y  +R    L PDD  G
Sbjct: 191 DEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAG 250

Query: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVST-IRGELFFF 311
           +Q LYG+  P +         +  + T    P EP   PD C +  DA+    RG+ + F
Sbjct: 251 IQALYGKKSPVIRDEEE---EETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAF 307

Query: 312 KAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA-FEDAQGHIWFFQGAQYWVYDGEKP 370
           K  +VW +      PG     S  W+GLP  +DAA +      I FF+G + W Y   K 
Sbjct: 308 KGDYVWTV--SDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFK- 364

Query: 371 VLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATD-W 429
            + P    +L  V   + AAL W P   K++ F+G  YW++    R   S  P+     +
Sbjct: 365 -MSPGFPKKLNRVEPNLDAALYW-PLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLF 422

Query: 430 RGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
            GVP++  AA    DG  YF +G++YW+ +  +++  +G+PR +  ++  C
Sbjct: 423 TGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQ-QLRVEKGYPRNISHNWMHC 472


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  226 bits (577), Expect = 3e-59
 Identities = 147/398 (36%), Positives = 210/398 (52%), Gaps = 50/398 (12%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132
           ++ PRCGVPD             F+L+ G  +WE+T+LTYRI  +  QL + +V + + +
Sbjct: 86  MKKPRCGVPDSGG----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKD 135

Query: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
           A ++WS  +PL FT + +G ADI I F +  HGD+ PFDGP GILAHAF P     GD H
Sbjct: 136 AFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAH 195

Query: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDC 250
           FD +ETWT       +L  VAAHEFGH LGL H++   ALM   Y FR     SL  DD 
Sbjct: 196 FDAEETWT-NTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDI 254

Query: 251 RGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP-PDACEASFDAVSTIRGELF 309
            G+Q +Y                  G+ +N I P  P  P P     +FDA++T+RGE+ 
Sbjct: 255 DGIQAIY------------------GLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEIL 296

Query: 310 FFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFED-AQGHIWFFQGAQYWVYDGE 368
           FFK  + WR R  QLQ       S  W  LP+ + AA+ED  +  I+ F+G QYW   G 
Sbjct: 297 FFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGY 355

Query: 369 KPVLG-PAPLTELGLVRFP-----VHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
             + G P  ++  G   FP     + AA+ +   ++K YFF    +WR+    + ++   
Sbjct: 356 DILQGYPKDISNYG---FPSSVQAIDAAVFY---RSKTYFFVNDQFWRYDNQRQFMEPGY 409

Query: 423 PRRATD-WRGVPSEIDAAFQDADGYAYFLRGRLYWKFD 459
           P+  +  + G+ S++DA FQ  + + +   G  Y+ FD
Sbjct: 410 PKSISGAFPGIESKVDAVFQQ-EHFFHVFSGPRYYAFD 446


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  224 bits (570), Expect = 2e-58
 Identities = 150/399 (37%), Positives = 206/399 (51%), Gaps = 36/399 (9%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           ++ PRCGVPD ++         R      +W+K  LTYRI ++   +   +V + +  AL
Sbjct: 95  IKKPRCGVPDVAN--------YRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMAL 146

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
           + WS   PL+F  ++ G ADIMI F    HGD  PFDGP G LAHAF P     GD HFD
Sbjct: 147 QAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFD 206

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPLSLSPDDCRG 252
             E WT+G + G +L  VAAHEFGH LGL H+T   ALM   Y ++  Y   L  DD +G
Sbjct: 207 NAEKWTMGTN-GFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKG 265

Query: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACE--ASFDAVSTIRGELFF 310
           +Q LYG        R   LG      T   AP    + PD C+  +SFDAV+ +  EL  
Sbjct: 266 IQALYG-------PRKVFLGK----PTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLL 314

Query: 311 FKAGFVWRLRGGQLQPGY-PALASRHWQGLPSPVDAAFEDAQ-GHIWFFQGAQYWVYDGE 368
           FK    WR R   L+ G  P+  +  +  L S VDAA+E A+ G  +FF+G  YW+  G 
Sbjct: 315 FKDRIFWR-RQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGF 373

Query: 369 KPVLGPAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPR 424
           +    P  + + G   FP H     A V+  E  K  FF G +Y+ +    R+++   P+
Sbjct: 374 QMQGPPRTIYDFG---FPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPK 430

Query: 425 RA-TDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVK 462
               ++ GV  +IDAA  + +GY YF  G   +K+D  K
Sbjct: 431 NTEEEFSGVNGQIDAAV-ELNGYIYFFSGPKTYKYDTEK 468


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  223 bits (567), Expect = 4e-58
 Identities = 146/416 (35%), Positives = 212/416 (50%), Gaps = 42/416 (10%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           +  PRCGVPD            R +  G  W K  +TYRI  +   + +E V   + +A 
Sbjct: 87  MHAPRCGVPDV--------HHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAF 138

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
           +VWS+VTPL F++++ G ADI++ FAR  HGD   FDG GGILAHAF P +   GD HFD
Sbjct: 139 QVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFD 198

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRY----PLSLSPDDC 250
            DE WT     GT+L   A HE GH LGL H++  KA+M  F T++Y       LS DD 
Sbjct: 199 EDEFWTT-HSGGTNLFLTAVHEIGHSLGLGHSSDPKAVM--FPTYKYVDINTFRLSADDI 255

Query: 251 RGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACE--ASFDAVSTIRGEL 308
           RG+Q LYG P                   N+  P   ++ P  C+   SFDAV+T+  ++
Sbjct: 256 RGIQSLYGDP-----------------KENQRLPNPDNSEPALCDPNLSFDAVTTVGNKI 298

Query: 309 FFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDG 367
           FFFK  F W L+  +       L S  W  LPS ++AA+E +A+  ++ F+  +YW+   
Sbjct: 299 FFFKDRFFW-LKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISN 357

Query: 368 EKPVLG-PAPLTELGLVRFPVHA-ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR 425
            +P    P  +   G   F     A V+ P   + YFF    YWR+    + +D   P+ 
Sbjct: 358 LRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKL 417

Query: 426 AT-DWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
            T +++G+  +IDA F   + Y YF +G   +++D +  +  +    L    +FGC
Sbjct: 418 ITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITK---TLKSNSWFGC 470


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  214 bits (545), Expect = 1e-55
 Identities = 118/312 (37%), Positives = 169/312 (54%), Gaps = 28/312 (8%)

Query: 75  LRPPRCGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133
           ++ PRCGVPD + G S  + R+KR+ L+G +W+   +TY I     ++   + R+ +  A
Sbjct: 96  MKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRA 155

Query: 134 LKVWSDVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTH 186
             VW +VTPLTF EV       G+   DI I FA  +HGD  PFDG GG LAHA+FP   
Sbjct: 156 FDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG 215

Query: 187 REGDVHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP-- 242
             GD HFD DE WT+G+    G DL  VA HE GH LGL+H+    A+M+ FY +     
Sbjct: 216 IGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDN 275

Query: 243 LSLSPDDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLE 286
             L  DD +G+Q +YG P   P  T   P + P   I   +                P  
Sbjct: 276 FKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335

Query: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346
           P A P+ C+ +F+ ++ +R E+F FK  + WR+R  ++  GYP   +  W+GLP  +DA 
Sbjct: 336 PGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAV 395

Query: 347 FEDAQGHIWFFQ 358
           +E++ G+  FF+
Sbjct: 396 YENSDGNFVFFK 407



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 16/88 (18%)

Query: 365 YDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPR 424
           Y G KP +       L ++R              +++ F+ + +WR      RV    P 
Sbjct: 335 YPGAKPNICDGNFNTLAILR-------------REMFVFKDQWFWRVR--NNRVMDGYPM 379

Query: 425 RATD-WRGVPSEIDAAFQDADGYAYFLR 451
           + T  WRG+P  IDA ++++DG   F +
Sbjct: 380 QITYFWRGLPPSIDAVYENSDGNFVFFK 407


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  214 bits (545), Expect = 1e-55
 Identities = 153/422 (36%), Positives = 208/422 (49%), Gaps = 46/422 (10%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           ++ PRCGVPD          Q  + L G  W K +LTYRI+ +   + +  V + + E L
Sbjct: 86  MKTPRCGVPDVG--------QYGYTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGL 135

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGD-DLPFDGPGGILAHAFFPKTHREGDVHF 193
           +VWS VTPL FT++ +G ADIMI F    HG     FDGP G+L HAF P     GD HF
Sbjct: 136 EVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHF 195

Query: 194 DYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTF----RYPLSLSPDD 249
           D DE WT  D  G +L  VAAHEFGH LGL H+    ALM   Y      +YP  LS DD
Sbjct: 196 DEDENWT-KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYP--LSQDD 252

Query: 250 CRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDAC--EASFDAVSTIRGE 307
             G+Q +YG                 G+      P EP   P AC  + +FDA++T R E
Sbjct: 253 INGIQSIYG-----------------GLPKEPAKPKEPTI-PHACDPDLTFDAITTFRRE 294

Query: 308 LFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDG 367
           + FFK   +WR+        +  +AS  W  LP+ + AA+E+ +  I  F+   +W+  G
Sbjct: 295 VMFFKGRHLWRIYYDITDVEFELIAS-FWPSLPADLQAAYENPRDKILVFKDENFWMIRG 353

Query: 368 EKPVLG-PAPLTELGLV-RFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR 425
              +   P  +  LG   R     A V      K YFF G   WRF   T+ +D   P+R
Sbjct: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413

Query: 426 AT-DWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPA 484
               + G+   +DAAFQ   G+ +F RG   +++D +K K +    R     +F C EP 
Sbjct: 414 VVKHFPGISIRVDAAFQ-YKGFFFFSRGSKQFEYD-IKTKNITRIMRT--NTWFQCKEPK 469

Query: 485 NT 486
           N+
Sbjct: 470 NS 471


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  211 bits (536), Expect = 2e-54
 Identities = 151/440 (34%), Positives = 208/440 (47%), Gaps = 37/440 (8%)

Query: 51  WHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSD---------GLSARNR-----QK 96
           W + LP S     AT         +  PRCGV D +           L AR+R     +K
Sbjct: 68  WVSQLPVSGVLDRATLR------QMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKK 121

Query: 97  RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHE-GRADI 155
           RF   G +W K  L+YR++ +P  L +  VR  +  A ++WS+V+ L F E    G ADI
Sbjct: 122 RFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADI 181

Query: 156 MIDFARYWHGDDL--PFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVA 213
            + F +  H D L   FDGPGG LAHAF P   R G+ HFD DE W++   +G +L  V 
Sbjct: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLP---RRGEAHFDQDERWSLSRRRGRNLFVVL 238

Query: 214 AHEFGHVLGLQHTTAAKALMSAFY-TFRYPLSLSPDDCRGVQHLYGQP-WPTVTSRTPA- 270
           AHE GH LGL H+ A +ALM+ +Y        LS DD   VQ LYG+P   +V  + P  
Sbjct: 239 AHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGK 298

Query: 271 -LGPQAGIDTNEIAPLEPDAP-PDACEASFDAVSTIR-GELFFFKAGFVWRLRGGQLQPG 327
                   D+       P+   P  C +SFDA++  R  +L+ FK    W +        
Sbjct: 299 LFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEV-AADGNVS 357

Query: 328 YPALASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVYDGEKPVLGPAPLTEL-GLVRF 385
            P      W GLP  ++AA      G  +FF+G + W + G KPV G   L    GL R 
Sbjct: 358 EPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRH 417

Query: 386 PVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG 445
           P   A ++ P   ++  F+G  Y+       +V+   PR   DW G+P E+  A    DG
Sbjct: 418 P--DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDG 475

Query: 446 YAYFLRGRLYWKFDPVKVKA 465
              F R   YW+ D  K++A
Sbjct: 476 SIIFFRDDRYWRLDQAKLQA 495


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  170 bits (430), Expect = 3e-42
 Identities = 106/300 (35%), Positives = 148/300 (49%), Gaps = 30/300 (10%)

Query: 192 HFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCR 251
           ++D D  W    DQG  L  VAAHEFGH +GL+H+    ALM+  YT+     LS DD +
Sbjct: 330 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIK 389

Query: 252 GVQHLYGQPWPTV---TSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS--FDAVSTIRG 306
           G+Q LYG   P +   T  TP LGP                 P+ C+    FD ++ IRG
Sbjct: 390 GIQELYGAS-PDIDLGTGPTPTLGP---------------VTPEICKQDIVFDGIAQIRG 433

Query: 307 ELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGH-IWFFQGAQYWVY 365
           E+FFFK  F+WR    + +P  P L +  W  LP  +DA +E  Q     FF G +YW+Y
Sbjct: 434 EIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIY 493

Query: 366 DGEKPVLG-PAPLTELGLVR--FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
                  G P PLT LGL      V AA  W   K K Y F G  +WR++   +++D   
Sbjct: 494 SASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNK-KTYIFAGDKFWRYNEVKKKMDPGF 552

Query: 423 PRRATD-WRGVPSEIDAAFQ-DADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
           P+   D W  +P  +DA       G++YF +G  Y K +   +K+++     +  D+ GC
Sbjct: 553 PKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--GSIKSDWLGC 610



 Score =  129 bits (323), Expect = 8e-30
 Identities = 63/132 (47%), Positives = 81/132 (61%), Gaps = 8/132 (6%)

Query: 74  SLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133
           ++R PRCG PD ++          F     +W+K  +TYRI+ +   L  E V    A A
Sbjct: 46  TMRKPRCGNPDVAN--------YNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARA 97

Query: 134 LKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHF 193
            +VWSDVTPL F+ +H+G ADIMI+F R+ HGD  PFDG  G+LAHAF P T   GD HF
Sbjct: 98  FQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHF 157

Query: 194 DYDETWTIGDDQ 205
           D DE WT+G+ Q
Sbjct: 158 DDDELWTLGEGQ 169


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  170 bits (430), Expect = 3e-42
 Identities = 106/300 (35%), Positives = 148/300 (49%), Gaps = 30/300 (10%)

Query: 192 HFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCR 251
           ++D D  W    DQG  L  VAAHEFGH +GL+H+    ALM+  YT+     LS DD +
Sbjct: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIK 439

Query: 252 GVQHLYGQPWPTV---TSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS--FDAVSTIRG 306
           G+Q LYG   P +   T  TP LGP                 P+ C+    FD ++ IRG
Sbjct: 440 GIQELYGAS-PDIDLGTGPTPTLGP---------------VTPEICKQDIVFDGIAQIRG 483

Query: 307 ELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGH-IWFFQGAQYWVY 365
           E+FFFK  F+WR    + +P  P L +  W  LP  +DA +E  Q     FF G +YW+Y
Sbjct: 484 EIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIY 543

Query: 366 DGEKPVLG-PAPLTELGLVR--FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
                  G P PLT LGL      V AA  W   K K Y F G  +WR++   +++D   
Sbjct: 544 SASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNK-KTYIFAGDKFWRYNEVKKKMDPGF 602

Query: 423 PRRATD-WRGVPSEIDAAFQ-DADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
           P+   D W  +P  +DA       G++YF +G  Y K +   +K+++     +  D+ GC
Sbjct: 603 PKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--GSIKSDWLGC 660



 Score =  129 bits (323), Expect = 8e-30
 Identities = 63/132 (47%), Positives = 81/132 (61%), Gaps = 8/132 (6%)

Query: 74  SLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133
           ++R PRCG PD ++          F     +W+K  +TYRI+ +   L  E V    A A
Sbjct: 96  TMRKPRCGNPDVAN--------YNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARA 147

Query: 134 LKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHF 193
            +VWSDVTPL F+ +H+G ADIMI+F R+ HGD  PFDG  G+LAHAF P T   GD HF
Sbjct: 148 FQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHF 207

Query: 194 DYDETWTIGDDQ 205
           D DE WT+G+ Q
Sbjct: 208 DDDELWTLGEGQ 219


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  156 bits (395), Expect = 4e-38
 Identities = 82/187 (43%), Positives = 107/187 (57%), Gaps = 11/187 (5%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           L  P CGVPD SD   +  R K        W K  LTYRI+ +P  +    V+ ++  A+
Sbjct: 77  LHQPHCGVPDGSDTSISPGRCK--------WNKHTLTYRIINYPHDMKPSAVKDSIYNAV 128

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
            +WS+VTPL F +V  G ADI + F ++ H D  PFDGPGGIL HAF P +   G VHFD
Sbjct: 129 SIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFD 188

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDCRG 252
            +E W+   D G +L  VA HE GH LGLQH+    ++M   Y +  P    LS DD + 
Sbjct: 189 KNEHWS-ASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQR 247

Query: 253 VQHLYGQ 259
           +QHLYG+
Sbjct: 248 IQHLYGE 254


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  148 bits (374), Expect = 1e-35
 Identities = 108/311 (34%), Positives = 140/311 (45%), Gaps = 52/311 (16%)

Query: 192 HFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCR 251
           +FD D+ W    DQG  L  VAAHEFGH LGL H++  +ALM   Y F     L  DD  
Sbjct: 378 NFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVN 437

Query: 252 GVQHLYG-----QPWPTVT---------------------SRTPALG------------P 273
           G++HLYG     +P P  T                     S  P  G            P
Sbjct: 438 GIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPP 497

Query: 274 QAGIDTNEIAPLEPDAPPDACEAS-FDAVSTIRGELFFFKAGFVWRLRGGQ-LQPGYPAL 331
            AG  T    PL P    DAC  + FDA++ I  +L+ FK G  WR   G+  +P  P L
Sbjct: 498 TAGPSTATTVPLSP--VDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFL 555

Query: 332 ASRHWQGLPSPVDAAFED-AQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAA 390
            +  W  LP  +D+ FE+     ++FF G Q WVY G   VLGP  L +LGL        
Sbjct: 556 IADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGAS-VLGPRRLDKLGLGADVAQVT 614

Query: 391 LVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATD----WRGVPSEIDAAFQDADGY 446
                 + K+  F GR  WRF    + VD   PR A++    + GVP +    FQ  +  
Sbjct: 615 GALRSGRGKMLLFSGRRLWRFDVKAQMVD---PRSASEVDRMFPGVPLDTHDVFQYRE-K 670

Query: 447 AYFLRGRLYWK 457
           AYF + R YW+
Sbjct: 671 AYFCQDRFYWR 681



 Score =  102 bits (255), Expect = 6e-22
 Identities = 56/131 (42%), Positives = 71/131 (54%), Gaps = 12/131 (9%)

Query: 74  SLRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMA 131
           ++R PRCGVPD            RF    G  +W   ++TY I  +   L +  +    A
Sbjct: 93  AMRTPRCGVPDLG----------RFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFA 142

Query: 132 EALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
            A  +WS VTPLTFT V+   ADI+I F    HGD  PFDG  G+LAHAF P    +GD 
Sbjct: 143 RAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDA 202

Query: 192 HFDYDETWTIG 202
           HFD DE W++G
Sbjct: 203 HFDDDELWSLG 213


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  144 bits (364), Expect = 1e-34
 Identities = 81/187 (43%), Positives = 102/187 (54%), Gaps = 10/187 (5%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           ++ PRCGVPD ++     N  K        W    +TYRI+ +   L    V + +++AL
Sbjct: 82  MQKPRCGVPDVAEYSLFPNSPK--------WTSKVVTYRIVSYTRDLPHITVDRLVSKAL 133

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194
            +W    PL F +V  G ADIMI FAR  HGD  PFDGPG  LAHAF P T   GD HFD
Sbjct: 134 NMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFD 193

Query: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDCRG 252
            DE WT G   G + L  A HE GH LG+ H++   A+M   Y    P    LS DD +G
Sbjct: 194 EDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKG 253

Query: 253 VQHLYGQ 259
           +Q LYG+
Sbjct: 254 IQKLYGK 260


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  129 bits (324), Expect = 6e-30
 Identities = 134/453 (29%), Positives = 178/453 (39%), Gaps = 99/453 (21%)

Query: 56  PSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR---WEKTDLTY 112
           P  P+  P+    P  A S R PR  +      LS R  Q R    GG    + K  L++
Sbjct: 124 PPPPSAPPSPPGPPPRARSRRSPRAPL-----SLSRRGWQPRGYPDGGAAQAFSKRTLSW 178

Query: 113 RIL--RFPWQLVQEQVRQTMAEALKVWSDVTPLTFTE---VHEGRADIMIDFARYWH-GD 166
           R+L      QL     R+ +A A ++WS+VTPL F E         DI + F R  H G 
Sbjct: 179 RLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGC 238

Query: 167 DLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIG-DDQGTDLLQVAAHEFGHVLGLQH 225
              FDG G   AHA+     R GD+HFD DE +T    D G  LL+VA HE GHVLGL H
Sbjct: 239 PRAFDGSGQEFAHAW-----RLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPH 293

Query: 226 TTAAKALMSAFYTFRYP-LSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAP 284
           T    ++M   Y  + P   L   D + +Q LYG                          
Sbjct: 294 TYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYG-------------------------- 327

Query: 285 LEPDAPPDACEASFDAV-------------STIRGELFFFKAGFVW--RLRGGQLQPGYP 329
                   +CE SFD                 +R   +FF+  + W    R  + + G P
Sbjct: 328 --------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDP 379

Query: 330 ALASRHWQGLPSPVDAAFEDAQGHIW--------FFQGAQYWVYDGEKPVL--------G 373
                 W G+P+    AF     HIW        FFQG QYW YD +K            
Sbjct: 380 IQILTGWPGIPTHNIDAFV----HIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS 435

Query: 374 PAPLTELGLVRFPVHAALVWGPEKNK-IYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGV 432
              L   G    P      +   + K IYFF+    + F  +  RV +  P+R T+    
Sbjct: 436 YPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPA 495

Query: 433 PSEIDAAFQDAD----GYAY----FLRGRLYWK 457
               +  F++ D     YAY    F +G  YWK
Sbjct: 496 VIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWK 528


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  125 bits (313), Expect = 1e-28
 Identities = 87/219 (39%), Positives = 114/219 (52%), Gaps = 23/219 (10%)

Query: 56  PSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRIL 115
           P+ PA + A  +      S  PP   VP P   L+ R R+     +  RW+  +LTYRIL
Sbjct: 43  PAVPAWSAAQGDVAALGLSAVPPT-RVPGP---LAPRRRRYTLTPARLRWDHFNLTYRIL 98

Query: 116 RFPWQLVQ-EQVRQTMAEALKVWSDVTPLTFTEVH-EGRADIMIDFARYWHGDDLP---- 169
            FP  L+   + R+ +A A ++WSDV+P +F EV  E  +D+ I F    H D L     
Sbjct: 99  SFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALH 158

Query: 170 --FDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQG--------TDLLQVAAHEFGH 219
             FDGP G LAHAFFP     G +HFD  E W +G  +         TDL+ VAAHE GH
Sbjct: 159 HCFDGPTGELAHAFFPP---HGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGH 215

Query: 220 VLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYG 258
            LGL H+   +ALM    T R   +LS D+  G+  LYG
Sbjct: 216 ALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 42/101 (41%), Positives = 52/101 (51%), Gaps = 7/101 (6%)

Query: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134
           +R PRCG+ DP       N++    L  GRW K  LT+RIL  P  L     R  + +A 
Sbjct: 80  MRQPRCGLEDPF------NQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAF 133

Query: 135 KVWSDVTPLTFTEVHEGRADIMIDF-ARYWHGDDLPFDGPG 174
           + WS+V PLTF EV  G ADI + F  R        FDGPG
Sbjct: 134 QDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG 174


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 45/137 (32%), Positives = 71/137 (51%), Gaps = 13/137 (9%)

Query: 286 EPDAPPDACEAS-FDAVSTIR-GELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPV 343
           +P A  + C    FDA + ++ G LF F+  + + L    ++PGYP L    W G+  P+
Sbjct: 148 QPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEGPI 206

Query: 344 DAAFE--DAQGHIWFFQGAQYWVY-DGEKPVLGPAPLTELGLVRFP--VHAALVWGPE-- 396
           DAAF   + QG  + F+G+QYW + DG      P  +++ G    P  V AAL       
Sbjct: 207 DAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISD-GFDGIPDNVDAALALPAHSY 265

Query: 397 --KNKIYFFRGRDYWRF 411
             + ++YFF+G+ YW +
Sbjct: 266 SGRERVYFFKGKQYWEY 282



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 49/175 (28%), Positives = 71/175 (40%), Gaps = 20/175 (11%)

Query: 277 IDTNEIAPLEPDAPPDA--CEASFDAVST---IRGELFFFKAGFVWRLRGGQLQPGYPAL 331
           +D   + P  P    D    E   DA  T    +G+ + FK    WR   G L P YP  
Sbjct: 183 LDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRN 242

Query: 332 ASRHWQGLPSPVDAAFE------DAQGHIWFFQGAQYWVYDGE-KPVLGPAPLTELGLVR 384
            S  + G+P  VDAA          +  ++FF+G QYW Y  + +P       + L  V 
Sbjct: 243 ISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVF 302

Query: 385 FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA 439
              H A++       I+      +W    +  R    + R   DW GVP ++DAA
Sbjct: 303 --EHFAMMQRDSWEDIFELL---FWGRTSAGTRQPQFISR---DWHGVPGQVDAA 349



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 43/144 (29%), Positives = 65/144 (45%), Gaps = 12/144 (8%)

Query: 324 LQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAP--LTELG 381
           L PG P   +        P DA  +   G ++ F+G QY     EK V    P  + ++ 
Sbjct: 142 LHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRG-QYCYELDEKAVRPGYPKLIRDVW 200

Query: 382 LVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATD-WRGVPSEIDAAF 440
            +  P+ AA      + K Y F+G  YWRF      +D   PR  +D + G+P  +DAA 
Sbjct: 201 GIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGV--LDPDYPRNISDGFDGIPDNVDAAL 258

Query: 441 Q-DADGYA-----YFLRGRLYWKF 458
              A  Y+     YF +G+ YW++
Sbjct: 259 ALPAHSYSGRERVYFFKGKQYWEY 282



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 4/39 (10%)

Query: 400 IYFFRGRDYWRFHPSTRRVDS---PVPRR-ATDWRGVPS 434
           ++FF G  Y+R +  TRRVD+   P PR  A  W G P+
Sbjct: 436 VFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPA 474


>gi|11321561 hemopexin precursor [Homo sapiens]
          Length = 462

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 59/210 (28%), Positives = 87/210 (41%), Gaps = 24/210 (11%)

Query: 282 IAPLEPDAPPDACEA-----SFDAVSTI-RGELFFFKAGFVWRLRGGQLQPGYPALASRH 335
           +A  E    PD  E      SFDA +    G + FFK  FVW+      +     L S  
Sbjct: 35  VAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRE-----LISER 89

Query: 336 WQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPL--TELGLVRFPVHAALVW 393
           W+  PSPVDAAF      ++  +G + WVY  EK   G   L   E   +  P+ AA+  
Sbjct: 90  WKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVEC 149

Query: 394 GP---EKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFL 450
                +   + FF+G   W +  +T  +      +   W  V     +A +    Y Y  
Sbjct: 150 HRGECQAEGVLFFQGDREWFWDLATGTM------KERSWPAV-GNCSSALRWLGRY-YCF 201

Query: 451 RGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
           +G  + +FDPV+ +    +PR V   F  C
Sbjct: 202 QGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 38/96 (39%), Positives = 49/96 (51%), Gaps = 11/96 (11%)

Query: 121 LVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWH-GDDLPFDGPGGILAH 179
           L QE V +   +A ++WS+ + LTFT   E   DI++ F       D+ PF G  G LAH
Sbjct: 193 LPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFVFLADLHDNSPFYGHDGCLAH 252

Query: 180 AFFPKTHREGDVHFDYDET----------WTIGDDQ 205
           AF P     GDVHFD DET          W + +DQ
Sbjct: 253 AFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQ 288



 Score = 36.2 bits (82), Expect = 0.069
 Identities = 22/93 (23%), Positives = 41/93 (44%), Gaps = 5/93 (5%)

Query: 344 DAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHA----ALVWGPEKNK 399
           D  F++ +     F+ +++WV   E  +L   P        FP       A ++  +  K
Sbjct: 263 DVHFDNDETRTKDFRSSKHWVVQ-EDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGK 321

Query: 400 IYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGV 432
            +FF   +YWR+  + + VD+  P+   D  G+
Sbjct: 322 THFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 354


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.140    0.467 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,495,816
Number of Sequences: 37866
Number of extensions: 1357097
Number of successful extensions: 8383
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 229
Number of HSP's that attempted gapping in prelim test: 7039
Number of HSP's gapped (non-prelim): 1171
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.