Search of human proteins with 5729929

Search of human proteins with 5729929

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729929 matrix metalloproteinase 24 preproprotein [Homo
sapiens]
         (645 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]  1370   0.0  
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   856   0.0  
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   693   0.0  
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   649   0.0  
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   571   e-163
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   385   e-107
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   372   e-103
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   324   2e-88
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    316   5e-86
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   312   7e-85
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    311   2e-84
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   298   8e-81
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      296   3e-80
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   295   1e-79
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   293   4e-79
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   289   6e-78
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   267   2e-71
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                266   3e-71
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   246   5e-65
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      216   5e-56
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   216   5e-56
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    204   2e-52
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   146   5e-35
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   144   3e-34
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   142   1e-33
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       92   2e-18
gi|88853069 vitronectin precursor [Homo sapiens]                       79   1e-14
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    78   2e-14
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           78   3e-14
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           76   8e-14

>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score = 1370 bits (3545), Expect = 0.0
 Identities = 645/645 (100%), Positives = 645/645 (100%)

Query: 1   MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG 60
           MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
Sbjct: 1   MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG 60

Query: 61  NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI 120
           NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI
Sbjct: 61  NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI 120

Query: 121 PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG 180
           PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG
Sbjct: 121 PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG 180

Query: 181 ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG 240
           ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG
Sbjct: 181 ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG 240

Query: 241 FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM 300
           FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM
Sbjct: 241 FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM 300

Query: 301 APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360
           APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR
Sbjct: 301 APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360

Query: 361 PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ 420
           PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ
Sbjct: 361 PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ 420

Query: 421 FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL 480
           FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL
Sbjct: 421 FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL 480

Query: 481 RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK 540
           RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK
Sbjct: 481 RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK 540

Query: 541 GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV 600
           GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV
Sbjct: 541 GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV 600

Query: 601 NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645
           NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
Sbjct: 601 NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  856 bits (2212), Expect = 0.0
 Identities = 396/572 (69%), Positives = 468/572 (81%), Gaps = 4/572 (0%)

Query: 76  EAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMK 135
           E  F  + WL+ YGYL P D R S L SA+ +QSA++ MQQFYGI +TG +D+ TI+WMK
Sbjct: 38  EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97

Query: 136 KPRCGVPDHPHLSRRR--RNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFD 193
           KPRCGVPD    S +   R KRYALTGQKW+ KHITYSI N TPKVG+ +TRKAIR+AFD
Sbjct: 98  KPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFD 157

Query: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 253
           VWQ VTPLTFEEVPY E+++ +++ DI I FASGFHGDSSPFDGEGGFLAHAYFPGPGIG
Sbjct: 158 VWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 217

Query: 254 GDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFK 313
           GDTHFDSDEPWTLGN NHDGNDLFLVAVHELGHALGLEHS+DP+AIMAPFYQYMET NFK
Sbjct: 218 GDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK 277

Query: 314 LPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP 373
           LP DDLQGIQKIYGPP +   PTRPLPT+P  R   P++ +   +P+PPRPP G RPS P
Sbjct: 278 LPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTG-RPSYP 336

Query: 374 GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAY 433
           G KPNICDGNFNT+A+ R EMFVFKD+WFWR+RNNRV +GYPMQI  FW+GLP  IDA Y
Sbjct: 337 GAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVY 396

Query: 434 ERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKG 493
           E +DG FVFFKG+KYWVFK+ T++PGYPH L  LGS +P  GID+A+ WE VGKTYFFKG
Sbjct: 397 ENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKG 456

Query: 494 ERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS 553
           +RYWRYSEE +  DPGYPKPITVWKGIP++PQGAF+ KE  +TYFYKG++YWKF+NQ L 
Sbjct: 457 DRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516

Query: 554 VEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSL 613
           VEPGYPR+IL+D+MGC+    +R KE   P DDVDI++ +++   +V A+A+VIPCIL+L
Sbjct: 517 VEPGYPRSILKDFMGCD-GPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILAL 575

Query: 614 CILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645
           C+LVLVYT+FQFK K  P+ + Y KR +QEWV
Sbjct: 576 CLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  693 bits (1789), Expect = 0.0
 Identities = 352/669 (52%), Positives = 444/669 (66%), Gaps = 84/669 (12%)

Query: 34  RLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLP 93
           RLL LLL  L CL           G G           A++AE     +NWL+ YGYL  
Sbjct: 28  RLLPLLLVLLGCL-----------GLG---------VAAEDAEVH--AENWLRLYGYLPQ 65

Query: 94  YDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDH----PHLSR 149
                S + SA+ L SA++ MQ+FYGIPVTGVLD+ T EWMK+PRCGVPD        + 
Sbjct: 66  PSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANL 125

Query: 150 RRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYH 209
           RRR KRYALTG+KW   H+T+SI NYT K+G   + +A+R+AF VW++ TPL F+EVPY 
Sbjct: 126 RRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYE 185

Query: 210 EIKSDR-KEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGN 268
           +I+  R KEADIM+ FASGFHGDSSPFDG GGFLAHAYFPGPG+GGDTHFD+DEPWT  +
Sbjct: 186 DIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSS 245

Query: 269 ANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP 328
            +  GN+LFLVAVHELGHALGLEHSS+P+AIMAPFYQ+ +  NFKLP+DDL+GIQ++YG 
Sbjct: 246 TDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGT 305

Query: 329 PAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPP----LGDRPSTPGTK-------- 376
           P    +PT+PLPT+  RR   P  R     PRPP+PP      +RP  PG          
Sbjct: 306 PDGQPQPTQPLPTVTPRRPGRPDHRP----PRPPQPPPPGGKPERPPKPGPPVQPRATER 361

Query: 377 -----PNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDA 431
                PNICDG+F+TVA+ RGEMFVFK RWFWR+R+NRV + YPM I  FW+GLP  I A
Sbjct: 362 PDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISA 421

Query: 432 AYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFF 491
           AYER DGRFVFFKGD+YW+F+E  +EPGYP  L   G  +P + IDTA+ WEP G T+FF
Sbjct: 422 AYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFF 481

Query: 492 KGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQK 551
           + +RYWR++EE +  DPGYPKPI+VW+GIP +P+GAF+S +  YTYFYKG  YWKFDN++
Sbjct: 482 QEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNER 541

Query: 552 LSVEPGYPRNILRDWMGCNQKEVE-----------------------RRKERRLPQDDVD 588
           L +EPGYP++ILRD+MGC Q+ VE                          E  +   D D
Sbjct: 542 LRMEPGYPKSILRDFMGC-QEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD 600

Query: 589 ------------IMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTY 636
                       ++V + +V  +VN V V++P +L LC+L L Y + Q + K  P+ + Y
Sbjct: 601 FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY 660

Query: 637 YKRPVQEWV 645
            KR +QEWV
Sbjct: 661 CKRSLQEWV 669


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  649 bits (1674), Expect = 0.0
 Identities = 321/586 (54%), Positives = 408/586 (69%), Gaps = 26/586 (4%)

Query: 65  VAVAVARADEAEAP-FAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVT 123
           +  A+A    A++  F+ + WL+ YGYL P D R     S ++L +A++ MQ+FYG+ VT
Sbjct: 18  LGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVT 77

Query: 124 GVLDQTTIEWMKKPRCGVPDH--PHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGE 181
           G  D  T++ M++PRCGVPD     +    R KRYA+ G KW+   IT+ I NYTPKVGE
Sbjct: 78  GKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGE 137

Query: 182 LDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDR-KEADIMIFFASGFHGDSSPFDGEGG 240
             T +AIR+AF VW+  TPL F EVPY  I+    K+ADIMIFFA GFHGDS+PFDGEGG
Sbjct: 138 YATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGG 197

Query: 241 FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM 300
           FLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHSSDPSAIM
Sbjct: 198 FLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIM 257

Query: 301 APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360
           APFYQ+M+T NF LP DD +GIQ++YG   E   PT+  P                 QPR
Sbjct: 258 APFYQWMDTENFVLPDDDRRGIQQLYG--GESGFPTKMPP-----------------QPR 298

Query: 361 PP-RPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIE 419
              RP + D+P  P   PNICDGNF+TVA+ RGEMFVFK+RWFWR+RNN+V +GYPM I 
Sbjct: 299 TTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIG 358

Query: 420 QFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTA 479
           QFW+GLPA I+ AYER DG+FVFFKGDK+WVF E ++EPGYP  + ELG  LP + ID A
Sbjct: 359 QFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAA 418

Query: 480 LRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFY 539
           L W P GKTYFF+G +Y+R++EE RA D  YPK I VW+GIP++P+G+F+  +  +TYFY
Sbjct: 419 LFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFY 478

Query: 540 KGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGS 599
           KG  YWKF+NQKL VEPGYP++ LRDWMGC      R  E    + +V I+    +  G+
Sbjct: 479 KGNKYWKFNNQKLKVEPGYPKSALRDWMGC--PSGGRPDEGTEEETEVIIIEVDEEGGGA 536

Query: 600 VNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645
           V+A AVV+P +L L +L +   +F F+    P+ + Y +R + + V
Sbjct: 537 VSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  571 bits (1471), Expect = e-163
 Identities = 268/371 (72%), Positives = 305/371 (82%), Gaps = 3/371 (0%)

Query: 76  EAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMK 135
           E  F  + WL+ YGYL P D R S L SA+ +QSA++ MQQFYGI +TG +D+ TI+WMK
Sbjct: 38  EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97

Query: 136 KPRCGVPDHPHLSRRR--RNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFD 193
           KPRCGVPD    S +   R KRYALTGQKW+ KHITYSI N TPKVG+ +TRKAIR+AFD
Sbjct: 98  KPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFD 157

Query: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 253
           VWQ VTPLTFEEVPY E+++ +++ DI I FASGFHGDSSPFDGEGGFLAHAYFPGPGIG
Sbjct: 158 VWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 217

Query: 254 GDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFK 313
           GDTHFDSDEPWTLGN NHDGNDLFLVAVHELGHALGLEHS+DP+AIMAPFYQYMET NFK
Sbjct: 218 GDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK 277

Query: 314 LPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP 373
           LP DDLQGIQKIYGPP +   PTRPLPT+P  R   P++ +   +P+PPRPP G RPS P
Sbjct: 278 LPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTG-RPSYP 336

Query: 374 GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAY 433
           G KPNICDGNFNT+A+ R EMFVFKD+WFWR+RNNRV +GYPMQI  FW+GLP  IDA Y
Sbjct: 337 GAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVY 396

Query: 434 ERADGRFVFFK 444
           E +DG FVFFK
Sbjct: 397 ENSDGNFVFFK 407



 Score = 33.1 bits (74), Expect = 0.81
 Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 489 YFFKGERYWRYSEERRATDPGYPKPITV-WKGIPQAPQGAFISKEGYYTYF 538
           + FK + +WR    R     GYP  IT  W+G+P +    + + +G + +F
Sbjct: 358 FVFKDQWFWRVRNNR--VMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  385 bits (989), Expect = e-107
 Identities = 227/584 (38%), Positives = 307/584 (52%), Gaps = 74/584 (12%)

Query: 8   RAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAV 67
           RAA GP PPPP PG +      R+P  LLLLL                    G R   A 
Sbjct: 4   RAARGPGPPPPGPGLS------RLPLPLLLLL------------------ALGTRGGCA- 38

Query: 68  AVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLD 127
           A A A  AE    G  WL  +GYL P D     L + + L  A++ MQQF G+  TG+LD
Sbjct: 39  APAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILD 98

Query: 128 QTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNY--TPKVGELDTR 185
           + T+  MK PRC +PD P L++ RR +R A    KW ++++++ +  +     +G    R
Sbjct: 99  EATLALMKTPRCSLPDLPVLTQARR-RRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVR 157

Query: 186 KAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHA 245
             +  A  VW  + PL F EV           ADI I F+   H D  PFDG GG +AHA
Sbjct: 158 ALMYYALKVWSDIAPLNFHEVA-------GSAADIQIDFSKADHNDGYPFDGPGGTVAHA 210

Query: 246 YFPG-PGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFY 304
           +FPG     GDTHFD DE WT  +++  G DLF VAVHE GHA+GL H +   +IM P+Y
Sbjct: 211 FFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYY 270

Query: 305 Q--YMETHNFKLPQDD------LQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHE 356
           Q    +   + LP +D      L G+++   P A+P EP    P LP        E    
Sbjct: 271 QGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEP----PLLP--------EPPDN 318

Query: 357 RQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRL-RNNRVQEGYP 415
           R   PPR  +          P+ C  +F+ VA  RGE F FK ++FWRL R+  +    P
Sbjct: 319 RSSAPPRKDV----------PHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQP 368

Query: 416 MQIEQFWKGLPAR---IDAAYER-ADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCL 471
            Q+ +FW+GLP     +DA YER +D + VFFKGD+YWVFK+  VE GYP  + +    L
Sbjct: 369 AQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFS--L 426

Query: 472 PREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISK 531
           P  GID A  W    +TYFFK + YWRY +  R  DPGYP    +W+G+P     A    
Sbjct: 427 PPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWS 486

Query: 532 EGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVE 575
           +G  +YF++G++YWK  + +L V PGYP++  RDW+ C   + +
Sbjct: 487 DG-ASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQAD 529


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  372 bits (954), Expect = e-103
 Identities = 202/502 (40%), Positives = 287/502 (57%), Gaps = 38/502 (7%)

Query: 81  GQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 140
           G +WL  YGYL P     + L S + L+ A+  MQ+F G+P TG +D  T+  M+KPRC 
Sbjct: 32  GVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCS 91

Query: 141 VPDHPHLSRR-RRNKRYALTGQKWRQKHITYSIHNY--TPKVGELDTRKAIRQAFDVWQK 197
           +PD   ++   RR +RYAL+G  W+++ +T+ + ++  + ++ +   R  +  A   W  
Sbjct: 92  LPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGM 151

Query: 198 VTPLTFEEVPYHEIKSDR-KEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGD 255
            + LTF     HE+ S + +E DI+I FA  FH DS PFDG GG LAHA+FPG   I GD
Sbjct: 152 ESGLTF-----HEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGD 206

Query: 256 THFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQ--YMETHNFK 313
           THFD +E WT G+ + +G DLF VAVHE GHALGL HSS P++IM PFYQ    +   ++
Sbjct: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266

Query: 314 LPQDDLQGIQKIYG-PPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372
           L QDD  G+Q++YG  P  P +     P  P                 PP+PP     S 
Sbjct: 267 LSQDDRDGLQQLYGKAPQTPYDKPTRKPLAP-----------------PPQPPASPTHSP 309

Query: 373 PGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLR-NNRVQEGYPMQIEQFWKGLPAR--- 428
               P+ C+GNF+ +A  RGE F FK  WFWRL+ + ++    P ++ +FW+GLPA+   
Sbjct: 310 SFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRV 369

Query: 429 IDAAYER-ADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGK 487
           + AAY R  DGR + F G ++WVF++  +E G    L ELG   P E +D    W   GK
Sbjct: 370 VQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELG-LPPGEEVDAVFSWPQNGK 427

Query: 488 TYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKF 547
           TY  +G +YWRY E     DPGYP+ +++W+G P +P    +S  G  TYF+KG  YW+F
Sbjct: 428 TYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAG-DTYFFKGAHYWRF 486

Query: 548 DNQKLSVEPGYPRNILRDWMGC 569
               +  EP  P+ +  +W+ C
Sbjct: 487 PKNSIKTEPDAPQPMGPNWLDC 508


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  324 bits (830), Expect = 2e-88
 Identities = 192/494 (38%), Positives = 259/494 (52%), Gaps = 61/494 (12%)

Query: 81  GQNWL-KSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRC 139
           G+ +L K YG  +         +S   ++  +  MQ F G+ VTG LD +T+E M  PRC
Sbjct: 33  GERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRC 92

Query: 140 GVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVT 199
           GVPD  H        R    G  WR+ +ITY I+NYTP +   D   AIR+AF VW  VT
Sbjct: 93  GVPDVHHF-------REMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVT 145

Query: 200 PLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 259
           PL F ++       +   ADI++ FA G HGD   FDG+GG LAHA+ PG GIGGD HFD
Sbjct: 146 PLKFSKI-------NTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFD 198

Query: 260 SDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDL 319
            DE WT    +  G +LFL AVHE+GH+LGL HSSDP A+M P Y+Y++ + F+L  DD+
Sbjct: 199 EDEFWT---THSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDI 255

Query: 320 QGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNI 379
           +GIQ +YG P E                       ++R P P             ++P +
Sbjct: 256 RGIQSLYGDPKE-----------------------NQRLPNP-----------DNSEPAL 281

Query: 380 CDGN--FNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYE-RA 436
           CD N  F+ V     ++F FKDR+FW   + R +    + I   W  LP+ I+AAYE  A
Sbjct: 282 CDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL-ISSLWPTLPSGIEAAYEIEA 340

Query: 437 DGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERY 496
             +   FK DKYW+   +  EP YP S+   G     + ID A+      +TYFF   +Y
Sbjct: 341 RNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQY 400

Query: 497 WRYSEERRATDPGYPKPITV-WKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVE 555
           WRY E R+  DPGYPK IT  ++GI       F SK  YY YF++G + +++D     + 
Sbjct: 401 WRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYY-YFFQGSNQFEYDFLLQRIT 459

Query: 556 PGYPRNILRDWMGC 569
                N    W GC
Sbjct: 460 KTLKSN---SWFGC 470


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  316 bits (809), Expect = 5e-86
 Identities = 176/469 (37%), Positives = 252/469 (53%), Gaps = 58/469 (12%)

Query: 82  QNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGV 141
           Q++L+ +  L     +++  +    +   +  MQ+F+G+ VTG  ++ T++ MKKPRCGV
Sbjct: 34  QDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGV 93

Query: 142 PDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPL 201
           PD         N        KW + ++TY I NYTP++ E +  +AI+ AF++W   +PL
Sbjct: 94  PDSGGFMLTPGNP-------KWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPL 146

Query: 202 TFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSD 261
            F  +        + EADI I F    HGD+SPFDG  G LAHA+ PG GIGGD HFD++
Sbjct: 147 IFTRI-------SQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAE 199

Query: 262 EPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQG 321
           E WT  +AN++   LFLVA HE GH+LGL HSSDP A+M P Y + ET N+ LPQDD+ G
Sbjct: 200 ETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDG 256

Query: 322 IQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICD 381
           IQ IYG  + P++PT P                    P+P  P L               
Sbjct: 257 IQAIYGLSSNPIQPTGP------------------STPKPCDPSL--------------- 283

Query: 382 GNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFV 441
             F+ +   RGE+  FKDR+FWR R+ ++Q      I  FW  LP  I AAYE  D   +
Sbjct: 284 -TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLI 341

Query: 442 F-FKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYS 500
           F FKG++YW      +  GYP  +   G     + ID A+ +    KTYFF  +++WRY 
Sbjct: 342 FLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQFWRYD 399

Query: 501 EERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548
            +R+  +PGYPK I+  + GI       F  ++ ++ + + G  Y+ FD
Sbjct: 400 NQRQFMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  312 bits (799), Expect = 7e-85
 Identities = 177/438 (40%), Positives = 239/438 (54%), Gaps = 34/438 (7%)

Query: 134 MKKPRCGVPDHPH-LSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAF 192
           ++ PRCGVPD    LS R R KR+ L+G +W +  +TY I  +  ++ +   R+ + +A 
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134

Query: 193 DVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGI 252
            VW  VTPLTF EV  HE +     ADIMI FA  +HGD  PFDG GG LAHA+FP    
Sbjct: 135 KVWSDVTPLTFTEV--HEGR-----ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHR 187

Query: 253 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNF 312
            GD HFD DE WT+G+    G DL  VA HE GH LGL+H++   A+M+ FY +   +  
Sbjct: 188 EGDVHFDYDETWTIGD--DQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPL 243

Query: 313 KLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372
            L  DD +G+Q +YG         +P PT+        + R     P+         P  
Sbjct: 244 SLSPDDCRGVQHLYG---------QPWPTV--------TSRTPALGPQAGIDTNEIAPLE 286

Query: 373 PGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAA 432
           P   P+ C+ +F+ V+  RGE+F FK  + WRLR  ++Q GYP    + W+GLP+ +DAA
Sbjct: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346

Query: 433 YERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEP-VGKTYFF 491
           +E A G   FF+G +YWV+       G P  L ELG  L R  +  AL W P   K YFF
Sbjct: 347 FEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELG--LVRFPVHAALVWGPEKNKIYFF 403

Query: 492 KGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQK 551
           +G  YWR+    R  D   P+  T W+G+P     AF   +G Y YF +GR YWKFD  K
Sbjct: 404 RGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVK 462

Query: 552 LSVEPGYPRNILRDWMGC 569
           +    G+PR +  D+ GC
Sbjct: 463 VKALEGFPRLVGPDFFGC 480


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  311 bits (796), Expect = 2e-84
 Identities = 191/465 (41%), Positives = 246/465 (52%), Gaps = 57/465 (12%)

Query: 111 VSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITY 170
           +  MQ+F G+ VTG LD  T+E M+KPRCGVPD  H        R      KWR+ H+TY
Sbjct: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHF-------RTFPGIPKWRKTHLTY 116

Query: 171 SIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHG 230
            I NYTP + +     A+ +A  VW++VTPLTF  +          EADIMI FA   HG
Sbjct: 117 RIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLY-------EGEADIMISFAVREHG 169

Query: 231 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGL 290
           D  PFDG G  LAHAY PGPGI GD HFD DE WT    +  G +LFLVA HE+GH+LGL
Sbjct: 170 DFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGL 226

Query: 291 EHSSDPSAIMAPFYQYM-ETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPL-PTLPVRRIH 348
            HS++  A+M P Y  + +   F+L QDD+ GIQ +YGPP  P  P  PL PT PV    
Sbjct: 227 FHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP--PDSPETPLVPTEPV---- 280

Query: 349 SPSERKHERQPRPPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLR 406
                                P  PGT  N CD   +F+ V+  RGE+ +FKDR FWR +
Sbjct: 281 ---------------------PPEPGTPAN-CDPALSFDAVSTLRGEILIFKDRHFWR-K 317

Query: 407 NNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGYPHSLG 465
           + R  E     I  FW  LP+ +DAAYE      VF FKG+++W  +   V  GYP  + 
Sbjct: 318 SLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIH 377

Query: 466 ELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-WKGIPQAP 524
            LG       ID A+  +   KTYFF  ++YWR+ E+R + +PG+PK I   + GI    
Sbjct: 378 TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKI 437

Query: 525 QGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569
              F  +E  + YF+ G    +FD     V      N    W+ C
Sbjct: 438 DAVF--EEFGFFYFFTGSSQLEFDPNAKKVTHTLKSN---SWLNC 477


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  298 bits (764), Expect = 8e-81
 Identities = 190/473 (40%), Positives = 242/473 (51%), Gaps = 65/473 (13%)

Query: 82  QNWLKSYGYLLPYDSR-ASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 140
           Q +L+ Y Y L  D R      ++  +   +  MQ+F+G+ VTG  D  T++ MK+PRCG
Sbjct: 35  QKYLEKY-YNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93

Query: 141 VPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTP 200
           VPD         N R       W Q H+TY I NYTP +   D   AI +AF +W  VTP
Sbjct: 94  VPDVAQFVLTEGNPR-------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTP 146

Query: 201 LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDS 260
           LTF +V          +ADIMI F  G H D+SPFDG GG LAHA+ PGPGIGGD HFD 
Sbjct: 147 LTFTKV-------SEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199

Query: 261 DEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQ 320
           DE WT    N    +L  VA HELGH+LGL HS+D  A+M P Y +  + + +L QDD+ 
Sbjct: 200 DERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQDDID 254

Query: 321 GIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNIC 380
           GIQ IYG    P++P  P                                      P  C
Sbjct: 255 GIQAIYGRSQNPVQPIGP------------------------------------QTPKAC 278

Query: 381 DG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADG 438
           D    F+ +   RGE+  FKDR++ R  N    E     I  FW  LP  ++AAYE AD 
Sbjct: 279 DSKLTFDAITTIRGEVMFFKDRFYMR-TNPFYPEVELNFISVFWPQLPNGLEAAYEFADR 337

Query: 439 RFV-FFKGDKYWVFKEVTVEPGYPHSL-GELGSCLPREGIDTALRWEPVGKTYFFKGERY 496
             V FFKG+KYW  +   V  GYP  +    G     + ID AL  E  GKTYFF   +Y
Sbjct: 338 DEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKY 397

Query: 497 WRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548
           WRY E +R+ DPGYPK I   + GI       F+ K+G++ YF+ G   +KFD
Sbjct: 398 WRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM-KDGFF-YFFHGTRQYKFD 448


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  296 bits (759), Expect = 3e-80
 Identities = 183/440 (41%), Positives = 229/440 (52%), Gaps = 63/440 (14%)

Query: 114 MQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIH 173
           MQ+F+G+ VTG  D  T++ MK+PRCGVPD         N R       W Q H+TY I 
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR-------WEQTHLTYRIE 53

Query: 174 NYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSS 233
           NYTP +   D   AI +AF +W  VTPLTF +V          +ADIMI F  G H D+S
Sbjct: 54  NYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-------SEGQADIMISFVRGDHRDNS 106

Query: 234 PFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHS 293
           PFDG GG LAHA+ PGPGIGGD HFD DE WT    N    +L  VA HELGH+LGL HS
Sbjct: 107 PFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHS 163

Query: 294 SDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSER 353
           +D  A+M P Y +  + + +L QDD+ GIQ IYG    P++P  P               
Sbjct: 164 TDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYGRSQNPVQPIGP--------------- 206

Query: 354 KHERQPRPPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQ 411
                                  P  CD    F+ +   RGE+  FKDR++ R  N    
Sbjct: 207 ---------------------QTPKACDSKLTFDAITTIRGEVMFFKDRFYMR-TNPFYP 244

Query: 412 EGYPMQIEQFWKGLPARIDAAYERADGRFV-FFKGDKYWVFKEVTVEPGYPHSL-GELGS 469
           E     I  FW  LP  ++AAYE AD   V FFKG+KYW  +   V  GYP  +    G 
Sbjct: 245 EVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGF 304

Query: 470 CLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAF 528
               + ID AL  E  GKTYFF   +YWRY E +R+ DPGYPK I   + GI       F
Sbjct: 305 PRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF 364

Query: 529 ISKEGYYTYFYKGRDYWKFD 548
           + K+G++ YF+ G   +KFD
Sbjct: 365 M-KDGFF-YFFHGTRQYKFD 382


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  295 bits (754), Expect = 1e-79
 Identities = 184/491 (37%), Positives = 254/491 (51%), Gaps = 53/491 (10%)

Query: 63  AAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPV 122
           +A  ++ A  +E       Q +L+ Y Y L  D +      +  +   +  MQ+F G+ V
Sbjct: 16  SAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEV 74

Query: 123 TGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQ-KWRQKHITYSIHNYTPKVGE 181
           TG LD  T+E M+KPRCGVPD  H S        +  G  KWR+ H+TY I NYTP +  
Sbjct: 75  TGKLDTDTLEVMRKPRCGVPDVGHFS--------SFPGMPKWRKTHLTYRIVNYTPDLPR 126

Query: 182 LDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGF 241
                AI +A  VW++VTPLTF  +          EADIMI FA   HGD   FDG G  
Sbjct: 127 DAVDSAIEKALKVWEEVTPLTFSRLY-------EGEADIMISFAVKEHGDFYSFDGPGHS 179

Query: 242 LAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMA 301
           LAHAY PGPG+ GD HFD DE WT    +  G +LFLVA HELGH+LGL HS++  A+M 
Sbjct: 180 LAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHSANTEALMY 236

Query: 302 PFYQ-YMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360
           P Y  + E   F+L QDD+ GIQ +YGPP    E     P +P + + S SE        
Sbjct: 237 PLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEE----PLVPTKSVPSGSEM------- 285

Query: 361 PPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQI 418
                           P  CD   +F+ ++  RGE   FKDR+FWR  +   +  + + I
Sbjct: 286 ----------------PAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHL-I 328

Query: 419 EQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGID 477
             FW  LP+ +DAAYE      VF FKG+++W  +   V+ GYP  +  LG       ID
Sbjct: 329 SAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKID 388

Query: 478 TALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTY 537
            A+  +   KTYFF  ++YWR+ E  ++ + G+P+ I       +    A +   G++ Y
Sbjct: 389 AAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFF-Y 447

Query: 538 FYKGRDYWKFD 548
           F+ G   ++FD
Sbjct: 448 FFSGSSQFEFD 458



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 45/156 (28%), Positives = 62/156 (39%), Gaps = 13/156 (8%)

Query: 425 LPARIDAAYE-----RADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTA 479
           +PA+ D A          G ++FFK   +W       EP + H +      LP   +D A
Sbjct: 285 MPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEF-HLISAFWPSLPSY-LDAA 342

Query: 480 LRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQ---GAFISKEGYYT 536
                    + FKG  +W           GYP+ I    G P   +    A   KE   T
Sbjct: 343 YEVNSRDTVFIFKGNEFWAIRGNE--VQAGYPRGIHTL-GFPPTIRKIDAAVSDKEKKKT 399

Query: 537 YFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQK 572
           YF+    YW+FD    S+E G+PR I  D+ G   K
Sbjct: 400 YFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPK 435


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  293 bits (749), Expect = 4e-79
 Identities = 179/462 (38%), Positives = 235/462 (50%), Gaps = 63/462 (13%)

Query: 102 HSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQ 161
           ++A ++   +  MQ F+G+ VTG LD  T++ MKKPRCGVPD    +   R         
Sbjct: 59  NAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL------- 111

Query: 162 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIM 221
           KW + ++TY I NYTP +   +  KA ++AF VW  VTPL F  +  H+       ADIM
Sbjct: 112 KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRL--HD-----GIADIM 164

Query: 222 IFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAV 281
           I F    HGD  PFDG  G LAHA+ PGP  GGD HFD DE WT   ++  G +LFLVA 
Sbjct: 165 ISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT---SSSKGYNLFLVAA 221

Query: 282 HELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPT 341
           HE GH+LGL+HS DP A+M P Y Y    +F LP DD+QGIQ +YGP  E   P      
Sbjct: 222 HEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNP------ 275

Query: 342 LPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRW 401
                       KH + P    P L                + + +   RGE  +FKDR+
Sbjct: 276 ------------KHPKTPDKCDPSL----------------SLDAITSLRGETMIFKDRF 307

Query: 402 FWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGY 460
           FWRL   +V +      + FW  LP RIDAAYE      +F F+G K+W      +  GY
Sbjct: 308 FWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGY 366

Query: 461 PHSLGELGSCLPRE--GIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-W 517
           P  + ELG  LP+E   I  A+ +E  GKT  F G + WRY +     D  YP+ I   +
Sbjct: 367 PKKISELG--LPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDF 424

Query: 518 KGIPQAPQGAFISKEGYYTYFYKGR---DYWKFDNQKLSVEP 556
            GI       +  K G Y YF+ G    +Y  + N+ + V P
Sbjct: 425 PGIGDKVDAVY-EKNG-YIYFFNGPIQFEYSIWSNRIVRVMP 464


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  289 bits (739), Expect = 6e-78
 Identities = 176/463 (38%), Positives = 241/463 (52%), Gaps = 55/463 (11%)

Query: 111 VSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITY 170
           +  +Q F+G+ VTG LDQTT+  +KKPRCGVPD         N R      KW++  +TY
Sbjct: 72  IKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVA-------NYRLFPGEPKWKKNTLTY 124

Query: 171 SIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHG 230
            I  YTP +  ++  KA+  A   W    PL+F       ++ +  EADIMI F +G HG
Sbjct: 125 RISKYTPSMSSVEVDKAVEMALQAWSSAVPLSF-------VRINSGEADIMISFENGDHG 177

Query: 231 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGL 290
           DS PFDG  G LAHA+ PG G+GGDTHFD+ E WT+G    +G +LF VA HE GHALGL
Sbjct: 178 DSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT---NGFNLFTVAAHEFGHALGL 234

Query: 291 EHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSP 350
            HS+DPSA+M P Y+Y   + F LP+DD++GIQ +YGP    L      PTLP    H P
Sbjct: 235 AHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGK----PTLPHAPHHKP 290

Query: 351 SERKHERQPRPPRPPLGDRPSTPGTKPNICD--GNFNTVALFRGEMFVFKDRWFWRLRNN 408
           S                         P++CD   +F+ V +   E+ +FKDR FWR R  
Sbjct: 291 S------------------------IPDLCDSSSSFDAVTMLGKELLLFKDRIFWR-RQV 325

Query: 409 RVQEGY-PMQIEQFWKGLPARIDAAYERAD-GRFVFFKGDKYWVFKEVTVEPGYPHSLGE 466
            ++ G  P  I   +  L + +DAAYE A+ G   FFKG  YW+ +   ++ G P ++ +
Sbjct: 326 HLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ-GPPRTIYD 384

Query: 467 LGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQG 526
            G     + ID A+      KT FF G+ Y+ Y E +R  +  YPK              
Sbjct: 385 FGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQID 444

Query: 527 AFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569
           A +   G Y YF+ G   +K+D +K  V      +    W+GC
Sbjct: 445 AAVELNG-YIYFFSGPKTYKYDTEKEDVVSVVKSS---SWIGC 483


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  267 bits (683), Expect = 2e-71
 Identities = 178/507 (35%), Positives = 252/507 (49%), Gaps = 60/507 (11%)

Query: 77  APFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKK 136
           A  A  ++L  YGYL       S     + +  A+   Q+   +PV+G LD  T   M++
Sbjct: 24  AEVAPVDYLSQYGYLQK-PLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQ 82

Query: 137 PRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQ 196
           PRCG+ D       ++  +Y L G +WR+KH+T+ I N    +     R A+RQAF  W 
Sbjct: 83  PRCGLED----PFNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWS 137

Query: 197 KVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGD-----SSPFDGEGGFLAHAYFPGPG 251
            V PLTF+EV           ADI +     FHG      S+ FDG G  LAHA  P   
Sbjct: 138 NVAPLTFQEV-------QAGAADIRL----SFHGRQSSYCSNTFDGPGRVLAHADIPEL- 185

Query: 252 IGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHN 311
             G  HFD DE WT G   + G +L ++A HE+GHALGL HS    A+MAP Y+    H 
Sbjct: 186 --GSVHFDEDEFWTEG--TYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH- 240

Query: 312 FKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPS 371
           FKL  DD+ GIQ +YG  +            PV R     + + E    P  PP+   P+
Sbjct: 241 FKLHPDDVAGIQALYGKKS------------PVIR-----DEEEEETELPTVPPV---PT 280

Query: 372 TPGTKPNICDGNFNTVALF-RGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARID 430
            P   P+ C    + + L  RG+ + FK  + W + ++    G   ++   W+GLP  +D
Sbjct: 281 EPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDS--GPGPLFRVSALWEGLPGNLD 338

Query: 431 AAYERADGRFV-FFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTY 489
           AA      +++ FFKGDK W +    + PG+P  L  +        +D AL W    K +
Sbjct: 339 AAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRV-----EPNLDAALYWPLNQKVF 393

Query: 490 FFKGERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548
            FKG  YW++ E  R     YPKPI  ++ G+P  P  A   ++G   YF+KG+ YW+  
Sbjct: 394 LFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDG-RVYFFKGKVYWRL- 451

Query: 549 NQKLSVEPGYPRNILRDWMGCNQKEVE 575
           NQ+L VE GYPRNI  +WM C  + ++
Sbjct: 452 NQQLRVEKGYPRNISHNWMHCRPRTID 478


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  266 bits (681), Expect = 3e-71
 Identities = 165/447 (36%), Positives = 227/447 (50%), Gaps = 63/447 (14%)

Query: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166
           +   +  MQ F+G+ VTG LD  T+E MK PRCGVPD           +Y  T   WR+ 
Sbjct: 59  IDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVG---------QYGYTLPGWRKY 109

Query: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226
           ++TY I NYTP +      +AI++  +VW KVTPL F ++        +  ADIMI F +
Sbjct: 110 NLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIADIMIAFRT 162

Query: 227 GFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELG 285
             HG     FDG  G L HA+ PGPG+GGDTHFD DE WT   A   G +LFLVA HE G
Sbjct: 163 RVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFLVAAHEFG 219

Query: 286 HALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP-PAEPLEPTRPLPTLPV 344
           HALGL HS+D +A+M P Y  ++   + L QDD+ GIQ IYG  P EP +P  P      
Sbjct: 220 HALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEP------ 273

Query: 345 RRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGN--FNTVALFRGEMFVFKDRWF 402
                                         T P+ CD +  F+ +  FR E+  FK R  
Sbjct: 274 ------------------------------TIPHACDPDLTFDAITTFRREVMFFKGRHL 303

Query: 403 WRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPH 462
           WR+  +     + + I  FW  LPA + AAYE    + + FK + +W+ +   V P YP 
Sbjct: 304 WRIYYDITDVEFEL-IASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPK 362

Query: 463 SLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-WKGIP 521
           S+  LG     + ID A+  +   KTYFF G   WR+ E  +  D G+P+ +   + GI 
Sbjct: 363 SIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422

Query: 522 QAPQGAFISKEGYYTYFYKGRDYWKFD 548
                AF  K G++ +F +G   +++D
Sbjct: 423 IRVDAAFQYK-GFF-FFSRGSKQFEYD 447


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  246 bits (628), Expect = 5e-65
 Identities = 171/516 (33%), Positives = 244/516 (47%), Gaps = 60/516 (11%)

Query: 74  EAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEW 133
           EAEA      +L+ YGYL   + +     ++     A+   Q    +PV+GVLD+ T+  
Sbjct: 35  EAEA------FLEKYGYL---NEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQ 85

Query: 134 MKKPRCGVPDHP---------------HLSRRRRNKRYALTGQKWRQKHITYSIHNYTPK 178
           M +PRCGV D                 H ++ RR KR+A  G KW ++H++Y + N+   
Sbjct: 86  MTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEH 145

Query: 179 VGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGD--SSPFD 236
           + E   R A+R AF +W  V+ L F E P          ADI + F  G H D   + FD
Sbjct: 146 LPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADIRLTFFQGDHNDGLGNAFD 199

Query: 237 GEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDP 296
           G GG LAHA+ P     G+ HFD DE W+L  +   G +LF+V  HE+GH LGL HS  P
Sbjct: 200 GPGGALAHAFLPR---RGEAHFDQDERWSL--SRRRGRNLFVVLAHEIGHTLGLTHSPAP 254

Query: 297 SAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHE 356
            A+MAP+Y+ +   +  L  DD+  +Q +YG P                 +  P +   +
Sbjct: 255 RALMAPYYKRL-GRDALLSWDDVLAVQSLYGKPLGGSV-----------AVQLPGKLFTD 302

Query: 357 RQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFR-GEMFVFKDRWFWRL-RNNRVQEGY 414
            +      P G RP T G  P  C  +F+ + + R  ++++FK   FW +  +  V E  
Sbjct: 303 FETWDSYSPQGRRPETQG--PKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360

Query: 415 PMQIEQFWKGLPARID-AAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPR 473
           P+Q  + W GLP  I+ AA    DG F FFKG + W F+      G P      G  LPR
Sbjct: 361 PLQ--ERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGG--LPR 416

Query: 474 EGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEG 533
              D AL + P+ +   FKG RY+  +      +P YP+ +  W GIP+   GA    +G
Sbjct: 417 HP-DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDG 475

Query: 534 YYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569
              +F   R YW+ D  KL             WMGC
Sbjct: 476 SIIFFRDDR-YWRLDQAKLQATTSGRWATELPWMGC 510


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  216 bits (550), Expect = 5e-56
 Identities = 127/318 (39%), Positives = 169/318 (53%), Gaps = 42/318 (13%)

Query: 257 HFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQ 316
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L Q
Sbjct: 330 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 385

Query: 317 DDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTK 376
           DD++GIQ++YG   +    T P PTL                           P TP   
Sbjct: 386 DDIKGIQELYGASPDIDLGTGPTPTLG--------------------------PVTP--- 416

Query: 377 PNIC--DGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYE 434
             IC  D  F+ +A  RGE+F FKDR+ WR    R +   P+ +  FW  LP +IDA YE
Sbjct: 417 -EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 475

Query: 435 RA-DGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKG 493
              + + VFF G++YW++   T+E GYP  L  LG     + +D A  W    KTY F G
Sbjct: 476 APQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAG 535

Query: 494 ERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKL 552
           +++WRY+E ++  DPG+PK I   W  IP         + G ++YF+KG  Y K +NQ L
Sbjct: 536 DKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSL 595

Query: 553 -SVEPGYPRNILRDWMGC 569
            SV+ G   +I  DW+GC
Sbjct: 596 KSVKFG---SIKSDWLGC 610



 Score =  144 bits (363), Expect = 3e-34
 Identities = 77/161 (47%), Positives = 93/161 (57%), Gaps = 14/161 (8%)

Query: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166
           L+  +  MQ+F+G+P TG LDQ TIE M+KPRCG PD         N  +     KW + 
Sbjct: 20  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA-------NYNFFPRKPKWDKN 72

Query: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226
            ITY I  YTP +       A  +AF VW  VTPL F  +  H+      EADIMI F  
Sbjct: 73  QITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--HD-----GEADIMINFGR 125

Query: 227 GFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 267
             HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 126 WEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 166


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  216 bits (550), Expect = 5e-56
 Identities = 127/318 (39%), Positives = 169/318 (53%), Gaps = 42/318 (13%)

Query: 257 HFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQ 316
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L Q
Sbjct: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435

Query: 317 DDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTK 376
           DD++GIQ++YG   +    T P PTL                           P TP   
Sbjct: 436 DDIKGIQELYGASPDIDLGTGPTPTLG--------------------------PVTP--- 466

Query: 377 PNIC--DGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYE 434
             IC  D  F+ +A  RGE+F FKDR+ WR    R +   P+ +  FW  LP +IDA YE
Sbjct: 467 -EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 525

Query: 435 RA-DGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKG 493
              + + VFF G++YW++   T+E GYP  L  LG     + +D A  W    KTY F G
Sbjct: 526 APQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAG 585

Query: 494 ERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKL 552
           +++WRY+E ++  DPG+PK I   W  IP         + G ++YF+KG  Y K +NQ L
Sbjct: 586 DKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSL 645

Query: 553 -SVEPGYPRNILRDWMGC 569
            SV+ G   +I  DW+GC
Sbjct: 646 KSVKFG---SIKSDWLGC 660



 Score =  144 bits (363), Expect = 3e-34
 Identities = 77/161 (47%), Positives = 93/161 (57%), Gaps = 14/161 (8%)

Query: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166
           L+  +  MQ+F+G+P TG LDQ TIE M+KPRCG PD         N  +     KW + 
Sbjct: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA-------NYNFFPRKPKWDKN 122

Query: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226
            ITY I  YTP +       A  +AF VW  VTPL F  +  H+      EADIMI F  
Sbjct: 123 QITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--HD-----GEADIMINFGR 175

Query: 227 GFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 267
             HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 176 WEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  204 bits (519), Expect = 2e-52
 Identities = 120/291 (41%), Positives = 168/291 (57%), Gaps = 34/291 (11%)

Query: 37  LLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDS 96
           L +L A+C LPG+          G      ++  + ++A      Q++LK + YL  YDS
Sbjct: 3   LTVLCAVCLLPGSLALPLPQEAGG------MSELQWEQA------QDYLKRF-YL--YDS 47

Query: 97  RASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRY 156
                 +A +L++ +  MQ+F+G+P+TG+L+   IE M+KPRCGVPD    S    +   
Sbjct: 48  ETK---NANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSP-- 102

Query: 157 ALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRK 216
                KW  K +TY I +YT  +  +   + + +A ++W K  PL F +V +        
Sbjct: 103 -----KWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGT------ 151

Query: 217 EADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDL 276
            ADIMI FA G HGDS PFDG G  LAHA+ PG G+GGD HFD DE WT G++   G + 
Sbjct: 152 -ADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSL--GINF 208

Query: 277 FLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYG 327
              A HELGH+LG+ HSSDP+A+M P Y   +  NFKL QDD++GIQK+YG
Sbjct: 209 LYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYG 259


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  146 bits (369), Expect = 5e-35
 Identities = 146/515 (28%), Positives = 206/515 (40%), Gaps = 134/515 (26%)

Query: 106 ALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPD--------------HPHLSRRR 151
           AL  AV   Q+   +P +G LD  T+  M +PRCGVPD               P  +R R
Sbjct: 84  ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSR 143

Query: 152 RNKRYALT----------------GQKWRQKHITYSI--HNYTPKVGELDTRKAIRQAFD 193
           R+ R  L+                 Q + ++ +++ +     + ++   D R+ +  AF 
Sbjct: 144 RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFR 203

Query: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH-GDSSPFDGEGGFLAHAYFPGPGI 252
           +W +VTPL F E    ++ +     DI + F  G H G    FDG G   AHA+      
Sbjct: 204 MWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL---- 255

Query: 253 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNF 312
            GD HFD DE +T   ++  G  L  VAVHE+GH LGL H+    +IM P Y   E   F
Sbjct: 256 -GDIHFDDDEHFTPPTSD-TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AF 312

Query: 313 KLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372
           +L   D + IQK+YG                                             
Sbjct: 313 ELDWSDRKAIQKLYGS-------------------------------------------- 328

Query: 373 PGTKPNICDGNFNTV-------------ALFRGEMFVFKDRWFW--RLRNNRVQEGYPMQ 417
                  C+G+F+T               + R   + F++ W+W    RNNR + G P+Q
Sbjct: 329 -------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQ 381

Query: 418 IEQFWKGLPA-RIDAAYE----RADGRFVFFKGDKYW--------VFKEVTVEPGYPHSL 464
           I   W G+P   IDA       + D R+ FF+G++YW           E      YP  +
Sbjct: 382 ILTGWPGIPTHNIDAFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLI 440

Query: 465 GELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKG-IPQ 522
            E    +P   +DTA         YFFK    + +   R      YPK IT V+   IPQ
Sbjct: 441 SEGFPGIP-SPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQ 499

Query: 523 APQGAFISKEGYYTY------FYKGRDYWKFDNQK 551
                 I    YY+Y      F+KG  YWK  N K
Sbjct: 500 NHPFRNID-SAYYSYAYNSIFFFKGNAYWKVVNDK 533



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 36/133 (27%), Positives = 56/133 (42%), Gaps = 13/133 (9%)

Query: 442 FFKGDKYWVFKEVTVEPGYPHSLGELGSC--LPREGIDTALR---WEPVGKTYFFKGERY 496
           FF+   YW+++       Y   +  L     +P   ID  +    W+   + YFF+G +Y
Sbjct: 358 FFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKR-DERYFFQGNQY 416

Query: 497 WRYSEERRAT------DPGYPKPITV-WKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDN 549
           WRY  ++            YPK I+  + GIP     AF  +     YF+K    + FD 
Sbjct: 417 WRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDV 476

Query: 550 QKLSVEPGYPRNI 562
            +  V   YP+ I
Sbjct: 477 NRNRVLNSYPKRI 489



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 12/35 (34%), Positives = 18/35 (51%)

Query: 534 YYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMG 568
           + TYF++   YW ++N+      G P  IL  W G
Sbjct: 354 FSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPG 388


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  144 bits (362), Expect = 3e-34
 Identities = 84/221 (38%), Positives = 116/221 (52%), Gaps = 20/221 (9%)

Query: 108 QSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQ-KWRQK 166
           ++    +QQF+    T +LD      + +P CGVPD    S           G+ KW + 
Sbjct: 52  ETQTQLLQQFHRNG-TDLLDMQMHALLHQPHCGVPDGSDTS--------ISPGRCKWNKH 102

Query: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226
            +TY I NY   +     + +I  A  +W  VTPL F++V          +ADI + F  
Sbjct: 103 TLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQV-------QNGDADIKVSFWQ 155

Query: 227 GFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGH 286
             H D  PFDG GG L HA+ P  G  G  HFD +E W+   A+  G +LFLVA HE+GH
Sbjct: 156 WAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWS---ASDTGYNLFLVATHEIGH 212

Query: 287 ALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYG 327
           +LGL+HS + S+IM P Y Y +   F+L  DD+Q IQ +YG
Sbjct: 213 SLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  142 bits (357), Expect = 1e-33
 Identities = 109/321 (33%), Positives = 152/321 (47%), Gaps = 38/321 (11%)

Query: 256 THFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLP 315
           ++FDSD+ W  G     G  LFLVA HE GHALGL+HSS P A+M P Y++  T    L 
Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLH 432

Query: 316 QDDLQGIQKIYGPPAEPLEP-----TRPLPTLPVR-------RIHSPSERKHERQPRPPR 363
           +DD+ GI+ +YGP  EP EP     T P PT P          +H PSER       PP 
Sbjct: 433 KDDVNGIRHLYGPRPEP-EPRPPTTTTPQPTAPPTVCPTGPPTVH-PSERPTAGPTGPPS 490

Query: 364 -----PPLGDRPSTPGTKP-----NICDGN-FNTVALFRGEMFVFKDRWFWRLRNNRVQE 412
                PP    PST  T P     + C+ N F+ +A    ++++FKD  +WR    R   
Sbjct: 491 AGPTGPPTAG-PSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSR 549

Query: 413 GY-PMQIEQFWKGLPARIDAAY-ERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSC 470
              P  I   W  LP ++D+ + ER   +  FF G + WV+   +V    P  L +LG  
Sbjct: 550 PQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLG 607

Query: 471 LPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPI-TVWKGIPQAPQGAFI 529
                +  ALR    GK   F G R WR+  + +  DP     +  ++ G+P      F 
Sbjct: 608 ADVAQVTGALR-SGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQ 666

Query: 530 SKEGYYTYFYKGRDYWKFDNQ 550
            +E    YF + R YW+  ++
Sbjct: 667 YRE--KAYFCQDRFYWRVSSR 685



 Score =  129 bits (325), Expect = 6e-30
 Identities = 82/233 (35%), Positives = 109/233 (46%), Gaps = 26/233 (11%)

Query: 35  LLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPY 94
           L+L+LL   CC             A  R   +  V    +       +   + Y Y   Y
Sbjct: 7   LVLVLLVLGCCF------------AAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGY 54

Query: 95  DSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNK 154
              A     +K+L  A+  +Q+   +P TG LD  T++ M+ PRCGVPD         + 
Sbjct: 55  TRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDL 114

Query: 155 RYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSD 214
                  KW   +ITY I NY+  +       A  +AF +W  VTPLTF  V        
Sbjct: 115 -------KWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVY------- 160

Query: 215 RKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 267
            ++ADI+I F    HGD  PFDG+ G LAHA+ PGPGI GD HFD DE W+LG
Sbjct: 161 SRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLG 213


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 68/192 (35%), Positives = 94/192 (48%), Gaps = 28/192 (14%)

Query: 152 RNKRYALTGQKWRQKH--ITYSIHNYTPKV-GELDTRKAIRQAFDVWQKVTPLTFEEVPY 208
           R +RY LT  + R  H  +TY I ++   +    +TR+A+  AF +W  V+P +F EV  
Sbjct: 75  RRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREV-- 132

Query: 209 HEIKSDRKEADIMIFFASGFHGDSSP------FDGEGGFLAHAYFPGPGIGGDTHFDSDE 262
               +  + +D+ I F    H D         FDG  G LAHA+FP  G     HFD  E
Sbjct: 133 ----APEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG---GIHFDDSE 185

Query: 263 PWTLGNANHDGN------DLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFK-LP 315
            W LG   +         DL  VA HE+GHALGL HS    A+M   +       +K L 
Sbjct: 186 YWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALM---HLNATLRGWKALS 242

Query: 316 QDDLQGIQKIYG 327
           QD+L G+ ++YG
Sbjct: 243 QDELWGLHRLYG 254


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 20/175 (11%)

Query: 334 EPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGN-FNTVA-LFR 391
           E   P P +   +      R     P  P+PP          +  +C G  F+    L  
Sbjct: 119 EEEAPAPEVGASKPEGIDSRPETLHPGRPQPP---------AEEELCSGKPFDAFTDLKN 169

Query: 392 GEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERAD--GRFVFFKGDKYW 449
           G +F F+ ++ + L    V+ GYP  I   W G+   IDAA+ R +  G+   FKG +YW
Sbjct: 170 GSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEGPIDAAFTRINCQGKTYLFKGSQYW 228

Query: 450 VFKEVTVEPGYPHSLGELGSCLPREGIDTAL-----RWEPVGKTYFFKGERYWRY 499
            F++  ++P YP ++ +    +P + +D AL      +    + YFFKG++YW Y
Sbjct: 229 RFEDGVLDPDYPRNISDGFDGIP-DNVDAALALPAHSYSGRERVYFFKGKQYWEY 282



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 49/144 (34%), Positives = 67/144 (46%), Gaps = 15/144 (10%)

Query: 415 PMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPRE 474
           P   E+   G P   DA  +  +G    F+G   +   E  V PGYP  + ++      E
Sbjct: 149 PPAEEELCSGKP--FDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGI---E 203

Query: 475 G-IDTAL-RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISK 531
           G ID A  R    GKTY FKG +YWR+  E    DP YP+ I+  + GIP     A    
Sbjct: 204 GPIDAAFTRINCQGKTYLFKGSQYWRF--EDGVLDPDYPRNISDGFDGIPDNVDAALALP 261

Query: 532 EGYYT-----YFYKGRDYWKFDNQ 550
              Y+     YF+KG+ YW++  Q
Sbjct: 262 AHSYSGRERVYFFKGKQYWEYQFQ 285



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 6/68 (8%)

Query: 391 RGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYE------RADGRFVFFK 444
           +G+ ++FK   +WR  +  +   YP  I   + G+P  +DAA            R  FFK
Sbjct: 216 QGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFK 275

Query: 445 GDKYWVFK 452
           G +YW ++
Sbjct: 276 GKQYWEYQ 283



 Score = 34.3 bits (77), Expect = 0.37
 Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 4/43 (9%)

Query: 483 EPVGKTYFFKGERYWRYSEERR---ATDPGYPKPIT-VWKGIP 521
           EP+   +FF G++Y+R +   R     DP YP+ I   W G P
Sbjct: 431 EPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCP 473



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 12/36 (33%), Positives = 23/36 (63%), Gaps = 3/36 (8%)

Query: 537 YFYKGRDYWKFDNQKL---SVEPGYPRNILRDWMGC 569
           +F+ G  Y++ + +     +V+P YPR+I + W+GC
Sbjct: 437 FFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGC 472


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 57/168 (33%), Positives = 80/168 (47%), Gaps = 22/168 (13%)

Query: 77  APFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKK 136
           A  A  ++L  YGYL       S     + +  A+   Q+   +PV+G LD  T   M++
Sbjct: 24  AEVAPVDYLSQYGYLQK-PLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQ 82

Query: 137 PRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQ 196
           PRCG+ D       ++  +Y L G +WR+KH+T+ I N    +     R A+RQAF  W 
Sbjct: 83  PRCGLED----PFNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWS 137

Query: 197 KVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGD-----SSPFDGEG 239
            V PLTF+EV           ADI +     FHG      S+ FDG G
Sbjct: 138 NVAPLTFQEV-------QAGAADIRL----SFHGRQSSYCSNTFDGPG 174


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 44/107 (41%), Positives = 60/107 (56%), Gaps = 16/107 (14%)

Query: 161 QKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADI 220
           QKW++        NY P + + D  +A  +AF++W K + LTF        +    E DI
Sbjct: 21  QKWQEDQ------NYMPNLPQEDVDRATGKAFELWSKASALTFT-------RDFESEGDI 67

Query: 221 MIFFA--SGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 265
           ++ F   +  H D+SPF G  G LAHA+ PGPGIGGD HFD+DE  T
Sbjct: 68  ILSFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)

Query: 430 DAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPR-EGIDTALRWEPVGKT 488
           D  ++  + R   F+  K+WV +E  +  GYP  +        R + ID A+  +  GKT
Sbjct: 103 DVHFDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKT 162

Query: 489 YFFKGERYWRYSEERRATDPGYPKPITVWKGI 520
           +FF    YWRY E  ++ D GYPK I    GI
Sbjct: 163 HFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 194



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 6/89 (6%)

Query: 487 KTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQ---GAFISKEGYYTYFYKGRD 543
           +T  F+  ++W   E++  +  GYP+ +      P+  +    A   K+   T+F+   +
Sbjct: 112 RTKDFRSSKHWVVQEDQLLS--GYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANE 169

Query: 544 YWKFDNQKLSVEPGYPRNILRDWMGCNQK 572
           YW++D    SV+ GYP+ I+ D  G ++K
Sbjct: 170 YWRYDENMQSVDAGYPK-IIDDLPGISKK 197


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 45/118 (38%), Positives = 61/118 (51%), Gaps = 10/118 (8%)

Query: 150 RRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYH 209
           R+R+    L   K  Q        NY P + + D  +A  +AF++W   + LTF      
Sbjct: 164 RQRDSSPVLEKLKQMQNFFGLKDQNYMPNLPQEDVDRATGKAFELWSNASALTFT----- 218

Query: 210 EIKSDRKEADIMIFFA--SGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 265
             +    E DI++ F   +  H D+SPF G  G LAHA+ PGPGIGGD HFD+DE  T
Sbjct: 219 --RDFESEGDIILSFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 273



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 1/92 (1%)

Query: 430 DAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPR-EGIDTALRWEPVGKT 488
           D  ++  + R   F+  K+WV +E  +  GYP  +        R + ID A+  +  GKT
Sbjct: 263 DVHFDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKT 322

Query: 489 YFFKGERYWRYSEERRATDPGYPKPITVWKGI 520
           +FF    YWRY E  ++ D GYPK I    GI
Sbjct: 323 HFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 354



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 6/89 (6%)

Query: 487 KTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQ---GAFISKEGYYTYFYKGRD 543
           +T  F+  ++W   E++  +  GYP+ +      P+  +    A   K+   T+F+   +
Sbjct: 272 RTKDFRSSKHWVVQEDQLLS--GYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANE 329

Query: 544 YWKFDNQKLSVEPGYPRNILRDWMGCNQK 572
           YW++D    SV+ GYP+ I+ D  G ++K
Sbjct: 330 YWRYDENMQSVDAGYPK-IIDDLPGISKK 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.139    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,520,998
Number of Sequences: 37866
Number of extensions: 1903283
Number of successful extensions: 23627
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 247
Number of HSP's that attempted gapping in prelim test: 17677
Number of HSP's gapped (non-prelim): 4698
length of query: 645
length of database: 18,247,518
effective HSP length: 109
effective length of query: 536
effective length of database: 14,120,124
effective search space: 7568386464
effective search space used: 7568386464
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.