Guide to the Human Genome
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Search of human proteins with 5729734

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729734 activator of S phase kinase [Homo sapiens]
         (674 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729734 activator of S phase kinase [Homo sapiens]                1356   0.0  
gi|22035682 DBF4 homolog B isoform 1 [Homo sapiens]                   181   1e-45
gi|13376671 DBF4 homolog B isoform 2 [Homo sapiens]                    78   2e-14
gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens]         50   7e-06
gi|38044112 restin isoform b [Homo sapiens]                            45   2e-04
gi|4506751 restin isoform a [Homo sapiens]                             45   2e-04
gi|148612801 KIAA1009 protein [Homo sapiens]                           43   8e-04
gi|144226234 metastasis suppressor 1 [Homo sapiens]                    41   0.003
gi|34878777 ring finger protein 20 [Homo sapiens]                      40   0.009
gi|158187521 A-kinase anchor protein 5 [Homo sapiens]                  39   0.020
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 38   0.027
gi|71061468 centromere protein E [Homo sapiens]                        38   0.027
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         38   0.035
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         38   0.035
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]     37   0.046
gi|9910266 kinesin family member 15 [Homo sapiens]                     37   0.078
gi|110815815 centlein isoform 1 [Homo sapiens]                         37   0.078
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso...    35   0.23 
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso...    35   0.23 
gi|4758650 kinesin family member 5C [Homo sapiens]                     35   0.30 
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         35   0.30 
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         35   0.30 
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]         35   0.30 
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         35   0.30 
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]         35   0.30 
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]         35   0.30 
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    35   0.30 
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho...    34   0.39 
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho...    34   0.39 
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho...    34   0.39 

>gi|5729734 activator of S phase kinase [Homo sapiens]
          Length = 674

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 674/674 (100%), Positives = 674/674 (100%)

Query: 1   MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI 60
           MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
Sbjct: 1   MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI 60

Query: 61  SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH 120
           SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
Sbjct: 61  SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH 120

Query: 121 PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE 180
           PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
Sbjct: 121 PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE 180

Query: 181 QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP 240
           QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
Sbjct: 181 QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP 240

Query: 241 FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL 300
           FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
Sbjct: 241 FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL 300

Query: 301 QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP 360
           QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
Sbjct: 301 QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP 360

Query: 361 VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS 420
           VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
Sbjct: 361 VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS 420

Query: 421 NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD 480
           NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
Sbjct: 421 NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD 480

Query: 481 HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ 540
           HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
Sbjct: 481 HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ 540

Query: 541 EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT 600
           EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
Sbjct: 541 EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT 600

Query: 601 EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT 660
           EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
Sbjct: 601 EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT 660

Query: 661 AFFSSPSTSTFTGF 674
           AFFSSPSTSTFTGF
Sbjct: 661 AFFSSPSTSTFTGF 674


>gi|22035682 DBF4 homolog B isoform 1 [Homo sapiens]
          Length = 615

 Score =  181 bits (460), Expect = 1e-45
 Identities = 112/308 (36%), Positives = 173/308 (56%), Gaps = 20/308 (6%)

Query: 45  PLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRI-- 102
           P  GK FYLDLP+    + L   I+ LGG +E FLSK++SY++S+++E K A++ G+   
Sbjct: 47  PFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVK-AESSGKSHR 105

Query: 103 ---SPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIP----- 154
              SP PS     T+    P  SH   S K  D+V LSRGK L++KAI++   I      
Sbjct: 106 GCPSPSPSEVRVETSAMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIRNQGSISGGGSG 165

Query: 155 -SNSILSNALSWGVKILHIDDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTG 213
            S+S+L+NA SWGV+ILH+D++  +++Q       +KK     +  G    + ++  +  
Sbjct: 166 GSSSLLTNARSWGVRILHVDEMMMHVQQLSLASLCVKKQQPK-KPEGTCPAAESRTRKVA 224

Query: 214 RLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQT 273
           RLK PF+K+ED S+ +RPF+ Q  + P I++   K  SPF+          T    R   
Sbjct: 225 RLKAPFLKIEDESRKFRPFHHQFKSFPEISFLGPKDASPFEAPTTLGSMHHT----RESK 280

Query: 274 DGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFA-QSNQYQVVDDIVS 332
           DG+    ++       ++KKGYCECC + +E+L  HL S QHR+FA +++ Y  VD I++
Sbjct: 281 DGEPSPRSAAHTM--PRRKKGYCECCQEAFEELHVHLQSAQHRSFALEAHLYAEVDRIIA 338

Query: 333 KLVFDFVE 340
           +L   F +
Sbjct: 339 QLSHSFAD 346


>gi|13376671 DBF4 homolog B isoform 2 [Homo sapiens]
          Length = 170

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/127 (40%), Positives = 71/127 (55%), Gaps = 18/127 (14%)

Query: 45  PLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRI-- 102
           P  GK FYLDLP+    + L   I+ LGG +E FLSK++SY++S+++E K A++ G+   
Sbjct: 47  PFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVK-AESSGKSHR 105

Query: 103 ---SPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSIL 159
              SP PS     T+    P  SH   S K  D+V LSRGK L++KAI+           
Sbjct: 106 GCPSPSPSEVRVETSAMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIR----------- 154

Query: 160 SNALSWG 166
            N +SWG
Sbjct: 155 -NQVSWG 160


>gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens]
          Length = 2354

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 55/238 (23%), Positives = 108/238 (45%), Gaps = 35/238 (14%)

Query: 290 KKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQV-VDDIVSKLVFDFVEYEKDTPKK 348
           +K++GYC  C  +Y +LE HL S QHR+  + ++ Q+    ++ + + D +++       
Sbjct: 2   QKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHP----- 56

Query: 349 KRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKK 408
               +   S S    + +      E V L     ++ +ED+  V++++        TE++
Sbjct: 57  ---YHCQESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDED-------ATEER 106

Query: 409 LLFISEPI------PHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQL-PLHKNKQEC- 460
              +SEPI      PH S E     +++S + S++   E   +Q    +  +  + ++C 
Sbjct: 107 PSEVSEPIEELHSRPHKSQE---GTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCN 163

Query: 461 ILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDL 518
           ++DI + T + ++L    V    CN  AS        ++S  +P   + T L PA  L
Sbjct: 164 LVDIGQATNNRSNLVRPPV---ICNAPASC-----LPESSNDRPVTANTTSLPPAAHL 213


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 65/357 (18%), Positives = 138/357 (38%), Gaps = 42/357 (11%)

Query: 220  VKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYG 279
            +K  D+ +L         N  F+  SI+      +  +  + +K  + K  ++       
Sbjct: 907  LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS--- 963

Query: 280  GTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVD---------DI 330
                 L+ K +     C+    +YE   T     +H    Q+ Q  ++D         + 
Sbjct: 964  ----DLEKKMETSHNQCQELKARYERA-TSETKTKHEEILQNLQKTLLDTEDKLKGAREE 1018

Query: 331  VSKLVFDFVEYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDT 390
             S L+ +  E  K   K K  + +  ++  +     +KTE    +E    +    Q +  
Sbjct: 1019 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1078

Query: 391  TVKEQNFLYKETQETEKKLLFI-SEPIPHPSNELRGLNEKMSNKCSMLSTAE-------D 442
            T+KE N    E     K+LL + ++ +     E+  L +  + K   LS  +       +
Sbjct: 1079 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1138

Query: 443  DIRQNFTQLPLHKNKQECILDISEHTLSENDLEELR---------VDHYKCNIQASVHV- 492
            ++ ++  ++  H+  +E      E ++  N L E++          D  K ++Q S+ + 
Sbjct: 1139 ELGRSRDEVTSHQKLEE------ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1192

Query: 493  SDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIF-THDSGLITINSSQEHLTVQAK 548
            S   T+      K +++  +   ++   K LHS+  T +S  + +    ++L +Q K
Sbjct: 1193 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1249



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 53/249 (21%), Positives = 112/249 (44%), Gaps = 43/249 (17%)

Query: 254 DVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSE 313
           +V K +S   + + +L +  DG  +    ++L+ K  + +   E   ++  +L   L  E
Sbjct: 377 EVAKATSHVGEIEQELALARDG--HDQHVLELEAKMDQLRTMVEAADREKVELLNQL--E 432

Query: 314 QHRNFAQSNQYQVVDDIVSKLVFD---------FVEYEKDTPKKKR----IKYSVGSLSP 360
           + +   +  Q++V ++ ++K   +          +E EKD   + +    ++  + S  P
Sbjct: 433 EEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 492

Query: 361 -----VSASVLKKTEQ-KEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISE 414
                +S S+L++    +EK+E   +++ D Q + T++KE     +ET + E K L+ + 
Sbjct: 493 AGDVDMSLSLLQEISSLQEKLE---VTRTDHQREITSLKEHFGAREETHQKEIKALYTA- 548

Query: 415 PIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDL 474
                + +L   NE + +K    +    D+      + L K+K E    I+ H   +  +
Sbjct: 549 -----TEKLSKENESLKSKLEHANKENSDV------IALWKSKLETA--IASH---QQAM 592

Query: 475 EELRVDHYK 483
           EEL+V   K
Sbjct: 593 EELKVSFSK 601



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 51/246 (20%), Positives = 100/246 (40%), Gaps = 42/246 (17%)

Query: 255 VDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQ 314
           +D  +S  K T+ KL    D D     S + + + KK +   E   ++ + LE    +E 
Sbjct: 713 IDNFTSQLKATEEKL---LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 769

Query: 315 HRNFAQSNQYQVVDDIVSKLVFDFVEYE--KDTPKKK----RIKYSVGSLSPVSAS---- 364
            +  + + + Q  +  ++ L  +  E    K+T +K+    + K++  S   VS      
Sbjct: 770 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 829

Query: 365 -VLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNEL 423
             + K  QKE  E  ++   D ++    + +    ++E  E E++L+   E +    N++
Sbjct: 830 ETVNKLHQKE--EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL---ENDI 884

Query: 424 RGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYK 483
             + +   +  S L+   D++R                       L E D+EEL++   K
Sbjct: 885 AEIMKMSGDNSSQLTKMNDELR-----------------------LKERDVEELQLKLTK 921

Query: 484 CNIQAS 489
            N  AS
Sbjct: 922 ANENAS 927


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 65/357 (18%), Positives = 138/357 (38%), Gaps = 42/357 (11%)

Query: 220  VKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYG 279
            +K  D+ +L         N  F+  SI+      +  +  + +K  + K  ++       
Sbjct: 942  LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS--- 998

Query: 280  GTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVD---------DI 330
                 L+ K +     C+    +YE   T     +H    Q+ Q  ++D         + 
Sbjct: 999  ----DLEKKMETSHNQCQELKARYERA-TSETKTKHEEILQNLQKTLLDTEDKLKGAREE 1053

Query: 331  VSKLVFDFVEYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDT 390
             S L+ +  E  K   K K  + +  ++  +     +KTE    +E    +    Q +  
Sbjct: 1054 NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113

Query: 391  TVKEQNFLYKETQETEKKLLFI-SEPIPHPSNELRGLNEKMSNKCSMLSTAE-------D 442
            T+KE N    E     K+LL + ++ +     E+  L +  + K   LS  +       +
Sbjct: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1173

Query: 443  DIRQNFTQLPLHKNKQECILDISEHTLSENDLEELR---------VDHYKCNIQASVHV- 492
            ++ ++  ++  H+  +E      E ++  N L E++          D  K ++Q S+ + 
Sbjct: 1174 ELGRSRDEVTSHQKLEE------ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1227

Query: 493  SDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIF-THDSGLITINSSQEHLTVQAK 548
            S   T+      K +++  +   ++   K LHS+  T +S  + +    ++L +Q K
Sbjct: 1228 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1284



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 51/246 (20%), Positives = 100/246 (40%), Gaps = 42/246 (17%)

Query: 255 VDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQ 314
           +D  +S  K T+ KL    D D     S + + + KK +   E   ++ + LE    +E 
Sbjct: 748 IDNFTSQLKATEEKL---LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804

Query: 315 HRNFAQSNQYQVVDDIVSKLVFDFVEYE--KDTPKKK----RIKYSVGSLSPVSAS---- 364
            +  + + + Q  +  ++ L  +  E    K+T +K+    + K++  S   VS      
Sbjct: 805 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864

Query: 365 -VLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNEL 423
             + K  QKE  E  ++   D ++    + +    ++E  E E++L+   E +    N++
Sbjct: 865 ETVNKLHQKE--EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL---ENDI 919

Query: 424 RGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYK 483
             + +   +  S L+   D++R                       L E D+EEL++   K
Sbjct: 920 AEIMKMSGDNSSQLTKMNDELR-----------------------LKERDVEELQLKLTK 956

Query: 484 CNIQAS 489
            N  AS
Sbjct: 957 ANENAS 962



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 56/235 (23%), Positives = 109/235 (46%), Gaps = 39/235 (16%)

Query: 266 QVKLRIQTDGDKYGGTSIQLQLKEKK-KKGYCECCLQ----KYEDLETHLLSEQHRNFAQ 320
           +V+L  Q + +K     +Q +++E+   KG  E   +    + ++LE  LL E+ +  A 
Sbjct: 424 KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTK--AD 481

Query: 321 SNQYQVVDDIVSKLVFD--FVEYEKDTPKKKR----IKYSVGSLSP-----VSASVLKKT 369
             Q ++ D  V+ +      +E EKD   + +    ++  + S  P     +S S+L++ 
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541

Query: 370 EQ-KEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNE 428
              +EK+E   +++ D Q + T++KE     +ET + E K L+ +      + +L   NE
Sbjct: 542 SSLQEKLE---VTRTDHQREITSLKEHFGAREETHQKEIKALYTA------TEKLSKENE 592

Query: 429 KMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYK 483
            + +K    +    D+      + L K+K E    I+ H   +  +EEL+V   K
Sbjct: 593 SLKSKLEHANKENSDV------IALWKSKLETA--IASH---QQAMEELKVSFSK 636


>gi|148612801 KIAA1009 protein [Homo sapiens]
          Length = 1403

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 74/310 (23%), Positives = 122/310 (39%), Gaps = 45/310 (14%)

Query: 189 LKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQK 248
           L+  STS +   K + SG +  +   L KP  K E             T     N +   
Sbjct: 542 LRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLS---------TRKKSENPTETD 592

Query: 249 PCSPFDVDKPSSMQKQTQVKL----RIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYE 304
            C  F  D      +  + KL    R+Q   DK+ G      L E+ K  + E    K +
Sbjct: 593 SCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQA---LIEQIKATFSE----KEK 645

Query: 305 DLET---HLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSPV 361
           +LE     L  +Q +   + NQ    D+ + +      E   +T KK+R  +   +  PV
Sbjct: 646 ELENKLEELKKQQEKELFKLNQ----DNYILQAKLSSFE---ETNKKQRWLHFGEAADPV 698

Query: 362 SASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSN 421
           +   LK+  QKE  E + + Q   QE++    +   L ++ ++ E+++   ++ +    +
Sbjct: 699 TGEKLKQI-QKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSL---FS 754

Query: 422 ELRGLNEKMSNKCSMLSTAEDDI---RQNFTQL-----PLHKNKQECILDISEHTLSEND 473
           E+  L E+M     +    ED      QNFT L        K K   + DI      + D
Sbjct: 755 EVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKR---LKQD 811

Query: 474 LEELRVDHYK 483
            + L VD  K
Sbjct: 812 KQALEVDFEK 821


>gi|144226234 metastasis suppressor 1 [Homo sapiens]
          Length = 755

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 67/281 (23%), Positives = 121/281 (43%), Gaps = 54/281 (19%)

Query: 314 QHRNF-AQSNQYQ--VVDDIVSKLVFDFVEYEK-----DTPKKKRIKYSVGSLSPVSASV 365
           +HR+  A+  Q+   ++D +++ L     E++K     D    K  K +   +   S+  
Sbjct: 85  RHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDT 144

Query: 366 LKKTEQKEKVELQHISQKDCQED-DTTVKEQNFLYKETQETEKKLL-------------F 411
           LK  ++ +K       + D Q   D+ +++ N  Y   +ETEK+ +             F
Sbjct: 145 LKLQKKAKK------GRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTF 198

Query: 412 ISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLP--LHKNKQECILDI----- 464
           IS   P    E+  L E      + L T  +D++ + T  P  L  + ++ ILD+     
Sbjct: 199 ISMLRPVIEEEISMLGE-----ITHLQTISEDLK-SLTMDPHKLPSSSEQVILDLKGSDY 252

Query: 465 --SEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKD 522
             S  T   +    +      C+   SV+ SD  + +SGS     S    + + +L ++ 
Sbjct: 253 SWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSD--SRSSGSHSHSPSSHYRYRSSNLAQQA 310

Query: 523 ---LHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNE 560
              L S+ +HDSG I+ ++       Q+K+P   PPE PN+
Sbjct: 311 PVRLSSVSSHDSGFISQDA------FQSKSPSPMPPEAPNQ 345


>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 39.7 bits (91), Expect = 0.009
 Identities = 47/242 (19%), Positives = 100/242 (41%), Gaps = 17/242 (7%)

Query: 254 DVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSE 313
           ++ K    QK+ ++ L +     K     +QL   EKK K   E   Q+ +DLE     E
Sbjct: 632 ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKE 691

Query: 314 QHRNFAQSNQYQVVDDIVSKL--VFDFVEY-EKDTPKKKRIKYSVGSLSPVSASVLKKTE 370
                   N+    +D + K+  V + +EY +K     K+ + ++ S   V+    +  +
Sbjct: 692 --------NKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQ 743

Query: 371 QKEKVELQHISQKD------CQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELR 424
           ++    +Q + +KD        E   + +    L +E +E   ++L +   +      +R
Sbjct: 744 EQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVR 803

Query: 425 GLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYKC 484
            L EK     S + T E ++      L ++K K      +++   ++ +L + ++  ++ 
Sbjct: 804 KLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQD 863

Query: 485 NI 486
            I
Sbjct: 864 EI 865


>gi|158187521 A-kinase anchor protein 5 [Homo sapiens]
          Length = 427

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 52/225 (23%), Positives = 93/225 (41%), Gaps = 13/225 (5%)

Query: 416 IPHPSNELRGLNEKM--SNKCSMLSTAEDDIRQNFTQLPLHKN--KQECILDISEHTLSE 471
           I  P    R  + K+   + CS+    E +I    TQ PL+    K +   D+SE  +S 
Sbjct: 130 IKFPRGPKRSNHSKIIEDSDCSIKVQEEAEILDIQTQTPLNDQATKAKSTQDLSEG-ISR 188

Query: 472 NDLEELRVDHYKCNIQASVHVS--DFSTDNSGSQPKQKSDTVLFPAKDLKEK-DLHSIFT 528
            D +E+   +   +  +   V   +   DN G    Q    +L   + +KEK D+     
Sbjct: 189 KDGDEVCESNVSNSTTSGEKVISVELGLDN-GHSAIQTGTLILEEIETIKEKQDVQP--Q 245

Query: 529 HDSGLITINSSQEHLTVQAKAPFHTPPEEP--NECDFKNMDSLPSGKIHRKVKIILGRNR 586
             S L T  +  +   +    P    P++    E     ++S P+GK +   +I+    +
Sbjct: 246 QASPLETSETDHQQPVLSDVPPLPAIPDQQIVEEASNSTLESAPNGKDYESTEIVAEETK 305

Query: 587 KENLEPNAEFDKRTEFITQEENRICSSPVQSLLDLFQTSEEKSEF 631
            ++ E + E D +   IT+E+++   S     + +  T  E SEF
Sbjct: 306 PKDTELSQESDFKENGITEEKSKSEESKRMEPIAIIITDTEISEF 350


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 38.1 bits (87), Expect = 0.027
 Identities = 38/192 (19%), Positives = 87/192 (45%), Gaps = 22/192 (11%)

Query: 365  VLKKTEQKEKVELQHIS-QKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNEL 423
            V ++T ++EK +L  +  Q   + ++ T   Q    +E Q+    LL  ++ +    +EL
Sbjct: 947  VQEETARREKQQLLDVQRQVALKSEEATATHQQL--EEAQKEHTHLLQSNQQLREILDEL 1004

Query: 424  RGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYK 483
            +    K+ ++  +L      ++++F+ L     K++       H L E  +EE   ++  
Sbjct: 1005 QARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ-------HLLREVTVEE---NNAS 1054

Query: 484  CNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHD------SGLITIN 537
             + +  +H+ D       +Q K+ S ++    +DL    L S+ +H+      +  + + 
Sbjct: 1055 PHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLY---LDSLSSHNVWHLLSAEGVALR 1111

Query: 538  SSQEHLTVQAKA 549
            S++E L  Q ++
Sbjct: 1112 SAKEFLVQQTRS 1123


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 38.1 bits (87), Expect = 0.027
 Identities = 74/349 (21%), Positives = 143/349 (40%), Gaps = 35/349 (10%)

Query: 173  DDIRYYIE-------QKKKELYL----LKKSSTSVRDGGKRVGSG-AQKTRTGRLKKPFV 220
            D +R YI        Q K+EL +    LK+   ++ +  + V    AQ   T  L+K   
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276

Query: 221  KVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTD----GD 276
            K+++   +       L N+  ++ + Q+  +  ++    S  K +    RI+ +     +
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSET-QETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335

Query: 277  KYGGTSIQLQLKEKKK---KGYCECCLQKYEDLETHL------LSEQHRNFAQSNQYQVV 327
            K+  +  +++   K++   K   E    K++ L+ H+      + E      QS   +  
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395

Query: 328  DDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP--VSASVLKKTEQKEKVELQHISQKDC 385
            D+  +K+V +  +++       RI+  +  LS     +    K+  KEK +LQ + +   
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455

Query: 386  QEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLST------ 439
             E D   +    +  +  ETE++L      +      +  L   +S K + +ST      
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515

Query: 440  AEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYKCNIQA 488
            A +D  QN  Q    K +Q  I  ISE     N+L++ + +H K    A
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK-EHRKAKDSA 1563


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 37.7 bits (86), Expect = 0.035
 Identities = 105/537 (19%), Positives = 202/537 (37%), Gaps = 103/537 (19%)

Query: 179 IEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTN 238
           IE++KK L L  K +T+ +  G+      QK +   +K   +++ +  Q  R    ++  
Sbjct: 339 IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ--EIKNMKLELTNSKQKERQSSEEIKQ 396

Query: 239 MPFINYSIQK---PCSPFDVDKPSSMQKQTQVKL-RIQTDGDKYGGTSIQLQLKEKKKKG 294
           +      +QK     S F+ D    M+++TQ KL +++ + D+  G  I +Q+K++  + 
Sbjct: 397 LMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI-VQMKQELIRQ 455

Query: 295 YCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYS 354
           +    + + E+++T    E                           Y   T  + +IK  
Sbjct: 456 H----MAQMEEMKTRHKGEMENALRS--------------------YSNITVNEDQIKLM 491

Query: 355 VGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISE 414
             +++ ++  +     QKEK++         +E    ++E+  L ++ ++  ++L F  E
Sbjct: 492 NVAINELNIKLQDTNSQKEKLK---------EELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 415 PIPHPSNELRGLNEKMSNKCSMLSTAED---------------------DIRQNFTQLPL 453
            I      +     K++     LST ED                     ++     +L +
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 454 HKNKQECILD-------------------ISEHTLS--ENDLE-ELRVDHYKCNIQASVH 491
            + ++  +LD                     E  LS  + DLE E R++  K      +H
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 492 VSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIF----THDSGLITINSSQEHLTVQA 547
                 D   ++  QK +T+ F   +L  K    I       D     +NS  E +T+Q 
Sbjct: 663 YKQ-QIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721

Query: 548 KAPFHTPPEEPNECDFKNMDSLPSGKIHRKV-KIILGRNRKENLEPNAEFDKRTEFITQE 606
                   E   E +    +    G + ++V ++ L     E      E D + +F   E
Sbjct: 722 N-------ELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE 774

Query: 607 -ENRICSSPVQSLLDLFQ-----TSEEKSEFLGFTSYTEKSGIC-NVLDIWEEENSD 656
            EN I     ++L D+ +     + EE+  FL       K  +    ++I  EEN D
Sbjct: 775 AENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 71/357 (19%), Positives = 143/357 (40%), Gaps = 82/357 (22%)

Query: 283  IQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYE 342
            I++  +E+K+KG  E  +Q+ + L+T LL +Q +        +  +D+  K    F + E
Sbjct: 728  IEILRQEEKEKGTLEQEVQELQ-LKTELLEKQMK--------EKENDLQEK----FAQLE 774

Query: 343  KDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKET 402
             +    K  K ++  +  +   V   ++++  + L  I  K   +D    KE   L +E 
Sbjct: 775  AENSILKDEKKTLEDMLKIHTPV---SQEERLIFLDSIKSKS--KDSVWEKEIEILIEEN 829

Query: 403  QETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECIL 462
            ++ +++ +               LNE++  + +  S AE +   N+ +L   + +  C+L
Sbjct: 830  EDLKQQCI--------------QLNEEIEKQRNTFSFAEKNFEVNYQEL---QEEYACLL 872

Query: 463  DISEHTLSENDLEELRVDHYKCNIQA---SVHVSDFSTDNSGSQPKQKSDTVLFPAKDLK 519
             + +      + +EL    YK  ++A    +H+   +      +     +   F A+ L+
Sbjct: 873  KVKDDLEDSKNKQELE---YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929

Query: 520  -----EKD----LHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMD--S 568
                 EKD    +  +       + ++     L+ Q K       ++  E  F N +  S
Sbjct: 930  MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK-------QKHGEISFLNEEVKS 982

Query: 569  LPSGKIH-----RKVKIILGRNRKENLEPNAEFDKRTEFITQEENRICSSPVQSLLD 620
            L   K       R+++II+  NR EN++                   C + V SLLD
Sbjct: 983  LKQEKEQVSLRCRELEIIINHNRAENVQS------------------CDTQVSSLLD 1021


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 37.7 bits (86), Expect = 0.035
 Identities = 105/537 (19%), Positives = 202/537 (37%), Gaps = 103/537 (19%)

Query: 179 IEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTN 238
           IE++KK L L  K +T+ +  G+      QK +   +K   +++ +  Q  R    ++  
Sbjct: 339 IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ--EIKNMKLELTNSKQKERQSSEEIKQ 396

Query: 239 MPFINYSIQK---PCSPFDVDKPSSMQKQTQVKL-RIQTDGDKYGGTSIQLQLKEKKKKG 294
           +      +QK     S F+ D    M+++TQ KL +++ + D+  G  I +Q+K++  + 
Sbjct: 397 LMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI-VQMKQELIRQ 455

Query: 295 YCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYS 354
           +    + + E+++T    E                           Y   T  + +IK  
Sbjct: 456 H----MAQMEEMKTRHKGEMENALRS--------------------YSNITVNEDQIKLM 491

Query: 355 VGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISE 414
             +++ ++  +     QKEK++         +E    ++E+  L ++ ++  ++L F  E
Sbjct: 492 NVAINELNIKLQDTNSQKEKLK---------EELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 415 PIPHPSNELRGLNEKMSNKCSMLSTAED---------------------DIRQNFTQLPL 453
            I      +     K++     LST ED                     ++     +L +
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 454 HKNKQECILD-------------------ISEHTLS--ENDLE-ELRVDHYKCNIQASVH 491
            + ++  +LD                     E  LS  + DLE E R++  K      +H
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 492 VSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIF----THDSGLITINSSQEHLTVQA 547
                 D   ++  QK +T+ F   +L  K    I       D     +NS  E +T+Q 
Sbjct: 663 YKQ-QIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721

Query: 548 KAPFHTPPEEPNECDFKNMDSLPSGKIHRKV-KIILGRNRKENLEPNAEFDKRTEFITQE 606
                   E   E +    +    G + ++V ++ L     E      E D + +F   E
Sbjct: 722 N-------ELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE 774

Query: 607 -ENRICSSPVQSLLDLFQ-----TSEEKSEFLGFTSYTEKSGIC-NVLDIWEEENSD 656
            EN I     ++L D+ +     + EE+  FL       K  +    ++I  EEN D
Sbjct: 775 AENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 71/357 (19%), Positives = 143/357 (40%), Gaps = 82/357 (22%)

Query: 283  IQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYE 342
            I++  +E+K+KG  E  +Q+ + L+T LL +Q +        +  +D+  K    F + E
Sbjct: 728  IEILRQEEKEKGTLEQEVQELQ-LKTELLEKQMK--------EKENDLQEK----FAQLE 774

Query: 343  KDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKET 402
             +    K  K ++  +  +   V   ++++  + L  I  K   +D    KE   L +E 
Sbjct: 775  AENSILKDEKKTLEDMLKIHTPV---SQEERLIFLDSIKSKS--KDSVWEKEIEILIEEN 829

Query: 403  QETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECIL 462
            ++ +++ +               LNE++  + +  S AE +   N+ +L   + +  C+L
Sbjct: 830  EDLKQQCI--------------QLNEEIEKQRNTFSFAEKNFEVNYQEL---QEEYACLL 872

Query: 463  DISEHTLSENDLEELRVDHYKCNIQA---SVHVSDFSTDNSGSQPKQKSDTVLFPAKDLK 519
             + +      + +EL    YK  ++A    +H+   +      +     +   F A+ L+
Sbjct: 873  KVKDDLEDSKNKQELE---YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929

Query: 520  -----EKD----LHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMD--S 568
                 EKD    +  +       + ++     L+ Q K       ++  E  F N +  S
Sbjct: 930  MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK-------QKHGEISFLNEEVKS 982

Query: 569  LPSGKIH-----RKVKIILGRNRKENLEPNAEFDKRTEFITQEENRICSSPVQSLLD 620
            L   K       R+++II+  NR EN++                   C + V SLLD
Sbjct: 983  LKQEKEQVSLRCRELEIIINHNRAENVQS------------------CDTQVSSLLD 1021


>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
          Length = 446

 Score = 37.4 bits (85), Expect = 0.046
 Identities = 44/184 (23%), Positives = 82/184 (44%), Gaps = 14/184 (7%)

Query: 259 SSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNF 318
           S MQ + Q K   Q + +     + +L+LK K++K Y E  L + ++    + SE  +  
Sbjct: 171 SDMQAELQKK---QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMG 227

Query: 319 AQSNQYQVVDDIVSKLVFDFVEYEKD-TPKKKRIKYSVGSLSPVSASVLKKTEQ-KEKVE 376
            + +Q Q       K +   V+ ++D T + +++K     L       L  TEQ K++ +
Sbjct: 228 IRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL------FLSLTEQRKDQKK 281

Query: 377 LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLL---FISEPIPHPSNELRGLNEKMSNK 433
           L+   ++  Q + T +K+Q  L  E  +  K+L     I   +      L G N+ +  +
Sbjct: 282 LEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341

Query: 434 CSML 437
            S L
Sbjct: 342 NSRL 345


>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 41/227 (18%), Positives = 99/227 (43%), Gaps = 22/227 (9%)

Query: 262  QKQTQVKLRIQTDGDKYGGTSIQLQLKE------KKKKGYCECCLQKYEDLETHLLSEQH 315
            +K+   KL +Q + DK   +   L++ E      +K+   CE  + K + LE  LL+ + 
Sbjct: 909  EKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEK 968

Query: 316  ----RNFAQSNQYQVVDDIVSKLV---------FDFVEYEKDTPKKKRIKYSVGSLSPVS 362
                   ++ +  +VV D+++++           + ++  K   K    KY+   +    
Sbjct: 969  VISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREE 1028

Query: 363  ASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNE 422
            + VL K ++ + ++L+   +     +D    E++ L ++     ++L  ++E     S  
Sbjct: 1029 SRVLIKKQEVDILDLKETLRLRILSEDI---ERDMLCEDLAHATEQLNMLTEASKKHSGL 1085

Query: 423  LRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTL 469
            L+   E+++ K +++   +  + Q   ++   KN+    +   EH +
Sbjct: 1086 LQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVM 1132


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 36.6 bits (83), Expect = 0.078
 Identities = 86/448 (19%), Positives = 171/448 (38%), Gaps = 58/448 (12%)

Query: 173 DDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPF---VKVEDMSQLY 229
           D++R   E++K+ L +L+ +  +V++  K+   G+  T   ++K+     ++ ED   ++
Sbjct: 553 DELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVW 612

Query: 230 RPF-YLQLTNMPF------INYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYG-GT 281
               Y +  N         +   + +      +DK +  +    V  R +    + G   
Sbjct: 613 NELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDD 672

Query: 282 SIQLQLKEKKKKGYCECCLQKYEDLETHLLS--EQHRNFAQSNQYQVVDDIVSKLVFDFV 339
            ++    EK  K   E  LQK  +LE  L S  ++ R   + N+  + ++   K +    
Sbjct: 673 EVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQ 732

Query: 340 EYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQ---- 395
           + + +T +K+  +   GS          K  +KE  ELQ +   + + + T+++ Q    
Sbjct: 733 QEDTETREKELEQIIKGS----------KDVEKENTELQ-VKISELETEVTSLRRQVAEA 781

Query: 396 NFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHK 455
           N L  E +E    +    +      +E+  +          + +   D +   T++    
Sbjct: 782 NALRNENEELINPMEKSHQSADRAKSEMATMK---------VRSGRYDCKTTMTKVKFKA 832

Query: 456 NKQECILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLF-- 513
            K+ C +    HT+  + ++ +       +      VS+ S+D S +Q  Q   T++   
Sbjct: 833 AKKNCSVG-RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSD-SEAQTSQTLGTIIVET 890

Query: 514 --------PAKDLKEKDLHSIFTHDSGLITINSSQEHLTVQAKAP---FHTPPEEPNECD 562
                     KD KE D     T DS        Q +L +  K P   FH    +     
Sbjct: 891 SQKISPTEDGKDQKESDP----TEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQ 946

Query: 563 FKNMDSLPSGKIHRKVKIILGRNRKENL 590
            KN     S   H  V   + R + +N+
Sbjct: 947 KKNCKMQKSS--HTAVPTRVNREKYKNI 972


>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
            a [Homo sapiens]
          Length = 1216

 Score = 35.0 bits (79), Expect = 0.23
 Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 341  YEKDTPKKKRIKYSVGSLSPVSASV-------LKKTEQKEKVELQHISQKDCQEDDTTVK 393
            Y +   K++ IK  +  L+ V+          LK+  +KEK EL+    K  QE  T  K
Sbjct: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084

Query: 394  EQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQ 446
             ++    E ++TE    +I E + +    ++ L E  S +   L     +IRQ
Sbjct: 1085 SKDKSQMEEEKTEMIRSYIQEVVQY----IKRLEEAQSKRQEKLVEKHKEIRQ 1133


>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
            b [Homo sapiens]
          Length = 1173

 Score = 35.0 bits (79), Expect = 0.23
 Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 341  YEKDTPKKKRIKYSVGSLSPVSASV-------LKKTEQKEKVELQHISQKDCQEDDTTVK 393
            Y +   K++ IK  +  L+ V+          LK+  +KEK EL+    K  QE  T  K
Sbjct: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084

Query: 394  EQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQ 446
             ++    E ++TE    +I E + +    ++ L E  S +   L     +IRQ
Sbjct: 1085 SKDKSQMEEEKTEMIRSYIQEVVQY----IKRLEEAQSKRQEKLVEKHKEIRQ 1133


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 19/127 (14%)

Query: 370 EQKEKV--ELQHISQKDCQEDDTTVKEQNFLYKETQETE---KKLLFISEPIPHPSNELR 424
           E+K+K+  E++ ++QK   E +    + N L  E QE E   +KLL +++       +L+
Sbjct: 726 EEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLK 785

Query: 425 GLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEH----------TLSENDL 474
           GL E +S +   L     ++R+ F Q    + K+   LD  +           +  EN+L
Sbjct: 786 GLEETVSRELQTL----HNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNL 841

Query: 475 EELRVDH 481
           E+L   H
Sbjct: 842 EQLTKVH 848


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 396 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 455

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 456 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 503

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 504 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 560

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 561 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 620

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 621 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 674

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 675 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 721


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 385 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 444

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 445 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 492

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 493 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 549

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 550 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 609

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 610 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 663

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 664 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 710


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 364 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 423

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 424 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 471

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 472 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 528

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 529 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 588

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 589 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 642

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 643 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 689


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 453 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 500

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 557

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 558 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 617

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 618 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 671

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 672 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 718


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 453 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 500

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 557

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 558 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 617

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 618 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 671

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 672 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 718


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 66/349 (18%), Positives = 136/349 (38%), Gaps = 49/349 (14%)

Query: 198 DGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDK 257
           D G  +G   + +       P V +  + +      +++  +  I   +QK     + ++
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 258 PSSMQKQTQVKLR------IQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLL 311
                KQ QV+L+      +  +  +    S  L  K K+ +        KYE+    +L
Sbjct: 453 -----KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQS-------KYEEAMKEVL 500

Query: 312 SEQHR------------NFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLS 359
           S Q +            N++  ++ +V ++ ++ L  D    +    + +R K  V  L 
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL---QNALEESERNKEKVRELE 557

Query: 360 PVSASVLKKTEQKEKVE-LQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFI-----S 413
                  K T  K  VE  + +    C   +   KE+ FL+++ QE +++++ +     S
Sbjct: 558 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 617

Query: 414 EPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSEND 473
           +     S+E   + E M+     L+    ++ Q      L+K  Q  + D  +    E+ 
Sbjct: 618 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ------LYKEAQAELEDYRKRKSLEDV 671

Query: 474 LEEL--RVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKE 520
             E   + +H K  +    +VS    +++ S+ K +   VL     LK+
Sbjct: 672 TAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQ 718


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 34.7 bits (78), Expect = 0.30
 Identities = 55/251 (21%), Positives = 106/251 (42%), Gaps = 48/251 (19%)

Query: 262 QKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQS 321
           Q+Q + + + Q + +++     +LQ +E KK+   E  L+K  +LE     E+ ++  + 
Sbjct: 388 QQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERR 447

Query: 322 NQYQVVDDIVSKLVFDFV--------------EYEKDTPKKKRIKYSVGSLSPVSASV-- 365
              +   +   +L ++ +              E  +   KKK +   + +L+     +  
Sbjct: 448 EAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISG 507

Query: 366 ------LKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHP 419
                 LKK  QK ++E   +  K C   D  + E   L +E QE + KL+++      P
Sbjct: 508 RLQDVRLKKQTQKTELE---VLDKQC---DLEIMEIKQLQQELQEYQNKLIYLV-----P 556

Query: 420 SNELRGLNEKMSNK---------CSML---STAEDDIRQNFTQLPLHKNKQECILDISEH 467
             +L  LNE++ N           S+L   S  ++++ Q   +  L   ++E    +SE 
Sbjct: 557 EKQL--LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKE-QLDALEKETASKLSEM 613

Query: 468 TLSENDLEELR 478
               N L+ELR
Sbjct: 614 DSFNNQLKELR 624


>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
           sapiens]
          Length = 638

 Score = 34.3 bits (77), Expect = 0.39
 Identities = 27/137 (19%), Positives = 55/137 (40%), Gaps = 2/137 (1%)

Query: 371 QKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKM 430
           Q+EK     + QK C   +  VKE+N   +E ++T  +L  + +        ++ L E+ 
Sbjct: 261 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 320

Query: 431 SNKCSMLSTAEDDIRQNFTQLPLHK--NKQECILDISEHTLSENDLEELRVDHYKCNIQA 488
            ++   L   E+ ++    +L      + Q  +L   ++      LE++           
Sbjct: 321 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 380

Query: 489 SVHVSDFSTDNSGSQPK 505
           +  + D   +NS  Q K
Sbjct: 381 ASEIEDLKLENSSLQEK 397


>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
           sapiens]
          Length = 725

 Score = 34.3 bits (77), Expect = 0.39
 Identities = 27/137 (19%), Positives = 55/137 (40%), Gaps = 2/137 (1%)

Query: 371 QKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKM 430
           Q+EK     + QK C   +  VKE+N   +E ++T  +L  + +        ++ L E+ 
Sbjct: 348 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407

Query: 431 SNKCSMLSTAEDDIRQNFTQLPLHK--NKQECILDISEHTLSENDLEELRVDHYKCNIQA 488
            ++   L   E+ ++    +L      + Q  +L   ++      LE++           
Sbjct: 408 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 467

Query: 489 SVHVSDFSTDNSGSQPK 505
           +  + D   +NS  Q K
Sbjct: 468 ASEIEDLKLENSSLQEK 484


>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
           sapiens]
          Length = 709

 Score = 34.3 bits (77), Expect = 0.39
 Identities = 27/137 (19%), Positives = 55/137 (40%), Gaps = 2/137 (1%)

Query: 371 QKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKM 430
           Q+EK     + QK C   +  VKE+N   +E ++T  +L  + +        ++ L E+ 
Sbjct: 332 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 391

Query: 431 SNKCSMLSTAEDDIRQNFTQLPLHK--NKQECILDISEHTLSENDLEELRVDHYKCNIQA 488
            ++   L   E+ ++    +L      + Q  +L   ++      LE++           
Sbjct: 392 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 451

Query: 489 SVHVSDFSTDNSGSQPK 505
           +  + D   +NS  Q K
Sbjct: 452 ASEIEDLKLENSSLQEK 468


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,946,337
Number of Sequences: 37866
Number of extensions: 1291667
Number of successful extensions: 3663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 3525
Number of HSP's gapped (non-prelim): 271
length of query: 674
length of database: 18,247,518
effective HSP length: 109
effective length of query: 565
effective length of database: 14,120,124
effective search space: 7977870060
effective search space used: 7977870060
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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