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Search of human proteins with 56788364
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56788364 tubulin, gamma complex associated protein 6 [Homo
sapiens]
(1819 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56788364 tubulin, gamma complex associated protein 6 [Homo sa... 3682 0.0
gi|156616297 tubulin, gamma complex associated protein 5 isoform... 102 3e-21
gi|156616299 tubulin, gamma complex associated protein 5 isoform... 100 1e-20
gi|5453660 tubulin, gamma complex associated protein 3 [Homo sap... 89 3e-17
gi|38454194 tubulin, gamma complex associated protein 4 [Homo sa... 84 1e-15
gi|5729840 tubulin, gamma complex associated protein 2 [Homo sap... 77 2e-13
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi... 60 2e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 59 3e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 59 3e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 59 3e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 59 3e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 58 1e-07
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 58 1e-07
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 57 1e-07
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 57 1e-07
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 55 6e-07
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 55 8e-07
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 55 8e-07
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 54 1e-06
gi|148746195 trichohyalin [Homo sapiens] 53 3e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 51 1e-05
gi|39930375 enabled homolog isoform b [Homo sapiens] 50 3e-05
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens] 50 3e-05
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 49 3e-05
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 49 3e-05
gi|56549694 enabled homolog isoform a [Homo sapiens] 49 4e-05
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 49 6e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 6e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 48 1e-04
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 48 1e-04
>gi|56788364 tubulin, gamma complex associated protein 6 [Homo
sapiens]
Length = 1819
Score = 3682 bits (9549), Expect = 0.0
Identities = 1819/1819 (100%), Positives = 1819/1819 (100%)
Query: 1 MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD 60
MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD
Sbjct: 1 MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD 60
Query: 61 MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS 120
MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS
Sbjct: 61 MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS 120
Query: 121 GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ 180
GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ
Sbjct: 121 GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ 180
Query: 181 VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD 240
VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD
Sbjct: 181 VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD 240
Query: 241 LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV 300
LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV
Sbjct: 241 LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV 300
Query: 301 GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL 360
GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL
Sbjct: 301 GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL 360
Query: 361 IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD 420
IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD
Sbjct: 361 IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD 420
Query: 421 SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG 480
SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
Sbjct: 421 SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG 480
Query: 481 AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV 540
AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
Sbjct: 481 AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV 540
Query: 541 YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK 600
YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK
Sbjct: 541 YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK 600
Query: 601 TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE 660
TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE
Sbjct: 601 TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE 660
Query: 661 KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR 720
KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR
Sbjct: 661 KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR 720
Query: 721 QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW 780
QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW
Sbjct: 721 QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW 780
Query: 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG 840
RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG
Sbjct: 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG 840
Query: 841 QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL 900
QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL
Sbjct: 841 QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL 900
Query: 901 PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA 960
PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA
Sbjct: 901 PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA 960
Query: 961 VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ 1020
VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ
Sbjct: 961 VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ 1020
Query: 1021 PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH 1080
PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH
Sbjct: 1021 PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH 1080
Query: 1081 GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA 1140
GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA
Sbjct: 1081 GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA 1140
Query: 1141 SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE 1200
SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE
Sbjct: 1141 SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE 1200
Query: 1201 SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV 1260
SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV
Sbjct: 1201 SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV 1260
Query: 1261 STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR 1320
STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR
Sbjct: 1261 STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR 1320
Query: 1321 LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL 1380
LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL
Sbjct: 1321 LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL 1380
Query: 1381 SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE 1440
SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE
Sbjct: 1381 SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE 1440
Query: 1441 PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN 1500
PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN
Sbjct: 1441 PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN 1500
Query: 1501 KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS 1560
KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS
Sbjct: 1501 KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS 1560
Query: 1561 VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC 1620
VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC
Sbjct: 1561 VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC 1620
Query: 1621 LSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI 1680
LSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI
Sbjct: 1621 LSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI 1680
Query: 1681 QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI 1740
QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI
Sbjct: 1681 QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI 1740
Query: 1741 FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ 1800
FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ
Sbjct: 1741 FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ 1800
Query: 1801 PHLEDFLLRINFNNYYQDA 1819
PHLEDFLLRINFNNYYQDA
Sbjct: 1801 PHLEDFLLRINFNNYYQDA 1819
>gi|156616297 tubulin, gamma complex associated protein 5 isoform a
[Homo sapiens]
Length = 1024
Score = 102 bits (254), Expect = 3e-21
Identities = 97/338 (28%), Positives = 146/338 (43%), Gaps = 49/338 (14%)
Query: 1497 SLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPL 1556
+L+ DY VE + +A+R+F LME G+ +F+K+ +T N
Sbjct: 705 NLMQTLKKDYRLVE-----YLQAMRNFFLMEGGDTMYDFYTSIFDKIREKET---WQNVS 756
Query: 1557 VLNSVLSKALQCSLHGDTPHAS----NLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPL 1612
LN L +A+ D+ S N+ A K LP +L L L YKV WP+
Sbjct: 757 FLNVQLQEAVGQRYPEDSSRLSISFENVDTAKKKLPV-------HILDGLTLSYKVPWPV 809
Query: 1613 NIVITEGCLSKYSGVFSFLLQLKLMMWALKDVCF-HLKRTAL-------LSHMAGSV--- 1661
+IVI+ C Y+ VF LLQ+K ++L + F L TA L H +V
Sbjct: 810 DIVISLECQKIYNQVFLLLLQIKWAKYSLDVLLFGELVSTAEKPRLKEGLIHEQDTVAQF 869
Query: 1662 ---------QFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRA 1712
Q ++ L + ++ HFV + YI +ILH T EF+ ++ DL+++ +
Sbjct: 870 GPQKEPVRQQIHRMFLLRVKLMHFVNSLHNYIMTRILHSTGLEFQHQVEEAKDLDQLIKI 929
Query: 1713 HAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFAL 1772
H YL R LL EK + V I + +L L F G G
Sbjct: 930 HYRYLSTIHDRCLLREKVSFVKEAIMKVLNLALMFAD----------GWQAGLGTWRMES 979
Query: 1773 MQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRI 1810
+++ + FK FL ++ K V RG PHLE L +
Sbjct: 980 IEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSL 1017
Score = 58.5 bits (140), Expect = 6e-08
Identities = 73/320 (22%), Positives = 127/320 (39%), Gaps = 51/320 (15%)
Query: 345 VLVKECELVKDVLNVLIGVVSA-TFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEY 403
VLV E +++++ L +L GV F L V+ + V+ + + S+L ++A Y
Sbjct: 263 VLVTETQVIRETLWLLSGVKKLFIFQLIDGK--VTVRNNIIVTHLTHSCLRSVLEQIAAY 320
Query: 404 GTCYTRLSHF----------SLQPVLDSLYSKGL-----VFQAFTSGLRRYLQYYRA--- 445
G RL F S+ P S+ K +QAF L +Y ++
Sbjct: 321 GQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRTYQAFMWALYKYFISFKEELA 380
Query: 446 ----CVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG-AVLPGTCGGGPRAAFPTGVK 500
C+++ T++L + QL+ L ++ G A +P RA+
Sbjct: 381 EIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTL 440
Query: 501 LLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEY 560
+ L + + S + +L SL + PY + + +W+ G D EF+IQ N
Sbjct: 441 YKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNV 500
Query: 561 -LSFRDKLYWTHGYVLISKEVED-----------------------CVPVFLKHIAHDIY 596
++ RD Y T+ +S++ E+ + FLK + I
Sbjct: 501 PVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQGPSSRQHTMVSFLKPVLKQII 560
Query: 597 VCGKTINLLK-LCCPRHYLC 615
+ GK++ LLK L C C
Sbjct: 561 MAGKSMQLLKNLQCAESTTC 580
>gi|156616299 tubulin, gamma complex associated protein 5 isoform b
[Homo sapiens]
Length = 1024
Score = 100 bits (250), Expect = 1e-20
Identities = 96/337 (28%), Positives = 146/337 (43%), Gaps = 49/337 (14%)
Query: 1497 SLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPL 1556
+L+ DY VE + +A+R+F LME G+ +F+K+ +T N
Sbjct: 705 NLMQTLKKDYRLVE-----YLQAMRNFFLMEGGDTMYDFYTSIFDKIREKET---WQNVS 756
Query: 1557 VLNSVLSKALQCSLHGDTPHAS----NLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPL 1612
LN L +A+ D+ S N+ A K LP +L L L YKV WP+
Sbjct: 757 FLNVQLQEAVGQRYPEDSSRLSISFENVDTAKKKLPV-------HILDGLTLSYKVPWPV 809
Query: 1613 NIVITEGCLSKYSGVFSFLLQLKLMMWALKDVCF-HLKRTAL-------LSHMAGSV--- 1661
+IVI+ C Y+ VF LLQ+K ++L + F L TA L H +V
Sbjct: 810 DIVISLECQKIYNQVFLLLLQIKWAKYSLDVLLFGELVSTAEKPRLKEGLIHEQDTVAQF 869
Query: 1662 ---------QFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRA 1712
Q ++ L + ++ HFV + YI +ILH T EF+ ++ DL+++ +
Sbjct: 870 GPQKEPVRQQIHRMFLLRVKLMHFVNSLHNYIMTRILHSTGLEFQHQVEEAKDLDQLIKI 929
Query: 1713 HAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFAL 1772
H YL R LL EK + V I + +L L F G G
Sbjct: 930 HYRYLSTIHDRCLLREKVSFVKEAIMKVLNLALMFAD----------GWQAGLGTWRMES 979
Query: 1773 MQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLR 1809
+++ + FK FL ++ K V RG PH E +L+
Sbjct: 980 IEKMESDFKNCHMFLVTILNKAVCRGSFPHCEYIMLK 1016
Score = 58.5 bits (140), Expect = 6e-08
Identities = 73/320 (22%), Positives = 127/320 (39%), Gaps = 51/320 (15%)
Query: 345 VLVKECELVKDVLNVLIGVVSA-TFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEY 403
VLV E +++++ L +L GV F L V+ + V+ + + S+L ++A Y
Sbjct: 263 VLVTETQVIRETLWLLSGVKKLFIFQLIDGK--VTVRNNIIVTHLTHSCLRSVLEQIAAY 320
Query: 404 GTCYTRLSHF----------SLQPVLDSLYSKGL-----VFQAFTSGLRRYLQYYRA--- 445
G RL F S+ P S+ K +QAF L +Y ++
Sbjct: 321 GQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRTYQAFMWALYKYFISFKEELA 380
Query: 446 ----CVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG-AVLPGTCGGGPRAAFPTGVK 500
C+++ T++L + QL+ L ++ G A +P RA+
Sbjct: 381 EIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTL 440
Query: 501 LLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEY 560
+ L + + S + +L SL + PY + + +W+ G D EF+IQ N
Sbjct: 441 YKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNV 500
Query: 561 -LSFRDKLYWTHGYVLISKEVED-----------------------CVPVFLKHIAHDIY 596
++ RD Y T+ +S++ E+ + FLK + I
Sbjct: 501 PVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQGPSSRQHTMVSFLKPVLKQII 560
Query: 597 VCGKTINLLK-LCCPRHYLC 615
+ GK++ LLK L C C
Sbjct: 561 MAGKSMQLLKNLQCAESTTC 580
>gi|5453660 tubulin, gamma complex associated protein 3 [Homo sapiens]
Length = 907
Score = 89.4 bits (220), Expect = 3e-17
Identities = 72/253 (28%), Positives = 119/253 (47%), Gaps = 10/253 (3%)
Query: 1500 NKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLN 1559
+K +D + L H +A+R +LL+ G+F + L DLL +L P L L
Sbjct: 542 SKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPEL---VRPATTLYQHNLT 598
Query: 1560 SVLSKALQCS-LHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITE 1618
+L A++ + D+P L ++ L DV S L Y VD P+ V T
Sbjct: 599 GILETAVRATNAQFDSPEILR-RLDVRLLEVSPGDTGWDVFS---LDYHVDGPIATVFTR 654
Query: 1619 GCLSKYSGVFSFLLQLKLMMWALKDVCF-HLKRTALLSHMAG-SVQFRQLQLFKHEMQHF 1676
C+S Y VF+FL + K M + L D+ H+ LL +M S Q + EM HF
Sbjct: 655 ECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHF 714
Query: 1677 VKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNV 1736
+ +Q YI ++L +W E ++ DL+ I AH +L + R LL + ++N
Sbjct: 715 IHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQ 774
Query: 1737 IHSIFSLVLKFRS 1749
+ ++F +++ ++
Sbjct: 775 LRAVFDQIIELQN 787
Score = 43.9 bits (102), Expect = 0.001
Identities = 68/304 (22%), Positives = 116/304 (38%), Gaps = 62/304 (20%)
Query: 347 VKECELVKDVLNVLIGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTC 406
+ E LV+D+L V G+ + + V+ ++S S+ ++E G
Sbjct: 245 ITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLS----RSLRDTAVRLSELGWL 300
Query: 407 YTRLSHFSLQPVLDSLYSKGLVFQAFTSGLRRYL-QYYRACV-----------------L 448
+ ++ ++ Q LD + GLV Q+F + L + L +YYR L
Sbjct: 301 HNKIRRYTDQRSLDRSF--GLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGL 358
Query: 449 STPPTLSLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQE 508
+ TL L + K+ +L+ LA L C G G +L S
Sbjct: 359 ESSLTLRRLLVWTYDPKI--RLKTLAALVD-------HCQGRK------GGELAS----- 398
Query: 509 ALHNCSNEHYPVLLSL----LKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFR 564
A+H + P + SL L P F++ W+Y G D Y EF + + + R
Sbjct: 399 AVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDR 458
Query: 565 DKLYWTHGYVLISKEVEDCVPVFL-KHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPR 623
W Y L + +P F+ + + + GK+IN L H +C P +
Sbjct: 459 ---LWHDKYTL----RKSMIPSFMTMDQSRKVLLIGKSINFL------HQVCHDQTPTTK 505
Query: 624 ISVI 627
+ +
Sbjct: 506 MIAV 509
>gi|38454194 tubulin, gamma complex associated protein 4 [Homo
sapiens]
Length = 666
Score = 84.0 bits (206), Expect = 1e-15
Identities = 63/221 (28%), Positives = 106/221 (47%), Gaps = 14/221 (6%)
Query: 1600 SCLELRYKVDWPLNIVITEGCLSKYSGVFSFLLQLKLMMWALKDV-CFHLKRTALLSHMA 1658
+ L L YKV WPL+I+ T L KY+ VF +LL ++ + L+ ++R L S+
Sbjct: 450 AALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQRKHLKSNQT 509
Query: 1659 GSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLH 1718
++++R ++ M V +Q Y+ +L + + ++ + D E I+ AH +L
Sbjct: 510 DAIKWR----LRNHMAFLVDNLQYYLQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLS 565
Query: 1719 KAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYN 1778
+ + + K PV + ++ I L F S L+SQ GP RGA A +
Sbjct: 566 NLLAQSFILLK--PVFHCLNEILDLCHSFCS-LVSQNLGPL-DERGA-----AQLSILVK 616
Query: 1779 TFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYYQDA 1819
F S LFK+++ + N L LLR+++N YY A
Sbjct: 617 GFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQA 657
>gi|5729840 tubulin, gamma complex associated protein 2 [Homo
sapiens]
Length = 902
Score = 77.0 bits (188), Expect = 2e-13
Identities = 89/351 (25%), Positives = 154/351 (43%), Gaps = 62/351 (17%)
Query: 344 PVLVKECELVKDVLNVLIGV----VSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSE 399
P+ +E +V+D+L VL+GV VSA + ++ F+V + +S I L+
Sbjct: 209 PLASQESAVVEDLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLS------IRELVHR 262
Query: 400 VAEYGTCYTRLSHFSLQPVLDSLYSKGLVFQAFTSGLRRYLQYYRACV-----LSTPPTL 454
+ Y+ ++ F + S + G V A + +R ++ + V L L
Sbjct: 263 ILPVAASYSAVTRFIEEK---SSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLL 319
Query: 455 SLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQEAL-HNC 513
SL + F + R + LA L +V G C GG LS L+ + +
Sbjct: 320 SLQKLWFYIQPAMRTMDILASLAT--SVDKGECLGG---------STLSLLHDRSFSYTG 368
Query: 514 SNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYL------SFRDKL 567
++ + L L K + PY + W+Y G+ D Y EFM++ HE + DK
Sbjct: 369 DSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVE-EHELRKERIQEDYNDK- 426
Query: 568 YWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVP-RISV 626
YW Y ++ ++ +P FL+ +A I GK +N+++ C DV P +
Sbjct: 427 YWDQRYTIVQQQ----IPSFLQKMADKILSTGKYLNVVR-------ECGHDVTCPVAKEI 475
Query: 627 IFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAR 677
I++L+E YV ++E+ ++ SK + ME ++EL+AH R
Sbjct: 476 IYTLKE--------RAYVEQIEKAFNYA--SKVLLDFLME--EKELVAHLR 514
Score = 68.9 bits (167), Expect = 4e-11
Identities = 62/286 (21%), Positives = 117/286 (40%), Gaps = 27/286 (9%)
Query: 1483 LMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEK 1542
L +R+ + + +K +D+ E L AH +++ + LM+ G+F DL E+
Sbjct: 479 LKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEE 538
Query: 1543 LGAGQTPGELLNPLVLNSVLSKALQCSLHGDTPHASNLS---------------LALKYL 1587
L + P E + P L ++L AL+ S P +L LA++
Sbjct: 539 L---RKPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETK 595
Query: 1588 PEVFAPNAPDV------LSCLELRYKVDWPLNIVITEGCLSKYSGVFSFLLQLKLMMWAL 1641
E +A L Y V WPL+++I L++Y +F + K + L
Sbjct: 596 QEKAMAHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQL 655
Query: 1642 KDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLA 1701
V +TA + + F + M +FV+ IQ Y+ +++ TW L
Sbjct: 656 CSVWIS-NKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLK 714
Query: 1702 TVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKF 1747
+ +++++ H +L + +LT ++ V + S+ + F
Sbjct: 715 SASNIDDVLGHHTGFLDTCLKDCMLTN--PELLKVFSKLMSVCVMF 758
>gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 673
Score = 60.1 bits (144), Expect = 2e-08
Identities = 94/406 (23%), Positives = 153/406 (37%), Gaps = 35/406 (8%)
Query: 1008 PPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENV 1067
PPR + S+ R + S G+P S +PT D++ + +
Sbjct: 161 PPRASLTMTPSTASLTRTPPRASPTGMP-----SRTSPTGMPSTASLTKMDSTASITRTL 215
Query: 1068 SDVAPT--QPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVA 1125
S +PT PR + G AS+S+ S + + T PR + G +S S+ ++ + +
Sbjct: 216 SRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASIT 275
Query: 1126 PTRPRWNT---HGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPAR 1182
T R +T G S AS+ + + + + PR + G +S S++ +S + ++
Sbjct: 276 RTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTP 335
Query: 1183 PRWNTHGHVSDASISLGESVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTH 1242
PR + S AS + S + T R + G S S+ + + R +
Sbjct: 336 PRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASPT 395
Query: 1243 GHVSDASISLGEPVSDVVSTRPRW------NTHVPIPPPHMVLGALSPEAEPNTPRPQQS 1296
G S AS++ P + R +T P P P A P P+ S
Sbjct: 396 GTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTP--------PRASPTGTPPRAS 447
Query: 1297 PPGHTSQSALSLGAQSTVLDCG-PRLPVEVG-PSLSSPSSGCGEGSISVGENVSDVAPTQ 1354
P G T A G QST G P G PS +SP+ S++ + + + +
Sbjct: 448 PTG-TPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKME 506
Query: 1355 PWWPNTPGDSVSEELGPGRSGDTEDLSPNWPLNSQEDTAAQSSPGR 1400
+ S P R+ T S P S A SP R
Sbjct: 507 --------STASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSR 544
Score = 45.4 bits (106), Expect = 5e-04
Identities = 100/449 (22%), Positives = 163/449 (36%), Gaps = 60/449 (13%)
Query: 924 TINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQ 983
+I L ++P P AS S P R +++ P+ L +G+
Sbjct: 210 SITRTLSRASPTGTPPRASPTGSPP---------RASLSMMPSTALLIRTPPRASPTGM- 259
Query: 984 LWEDSCGKMDACGSASR-----ETLLPSHPPRRAALEEGSSQ-------PTERLFGQVSG 1031
L S KMD+ S +R T P+ P RA+L S P G +S
Sbjct: 260 LSRTSLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSR 319
Query: 1032 GGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLG 1091
L D + I+ T PR + S AS + + T R + G S AS++
Sbjct: 320 TSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGL 379
Query: 1092 ESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTR--PRWNTHGHVSNASIRVGENVS 1149
S + T PR + G S AS+ TR PR + G +S SI ++ +
Sbjct: 380 SSTASPTGTPPRASPTGTPSTASL-----------TRKPPRASPTGMLSRTSITKMDSTA 428
Query: 1150 DVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGESVSDMAPTR 1209
T PR + G AS + S + + + G S AS + S + +
Sbjct: 429 SPTRTPPRASPTGTPPRASPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSP 488
Query: 1210 PRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDAS--------ISLGEPVSDVVS 1261
R + S S+ E+ + + SR + S AS +++G P ++
Sbjct: 489 SRASLTRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALT 548
Query: 1262 TRPRWNTHVPIP----------------PPHMVLGALSPEAEPNTPRPQQSPPGHTSQSA 1305
P + P P ++L + P A P + SP G S +
Sbjct: 549 RTPSRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSAL 608
Query: 1306 LS-LGAQSTVLDCGPRLPVEVGPSLSSPS 1333
L+ + + +++ PR P +SP+
Sbjct: 609 LTKMDSTASITRTPPRASPTETPPRASPT 637
Score = 38.1 bits (87), Expect = 0.079
Identities = 100/467 (21%), Positives = 164/467 (35%), Gaps = 92/467 (19%)
Query: 905 GAEPSVQTGMVPLLEVALQTINLDLPPSAPG------------EAPAAASTQPSRPQEYD 952
G+ P M+P + ++T PP A ++ A+ + PSRP
Sbjct: 231 GSPPRASLSMMPSTALLIRT-----PPRASPTGMLSRTSLTKMDSTASITRTPSRPSTAS 285
Query: 953 -FSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASR----------- 1000
T R +++ +P+ L +G+ L S KMD+ S SR
Sbjct: 286 PTGTPSRASLSMTPSTASLMRMLPRASPTGM-LSRTSLTKMDSTASISRTPPRASITRTP 344
Query: 1001 ---------ETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRPRWN 1051
T P+ P RA+ + P+ +S PTG T PR +
Sbjct: 345 SRASPTGKPSTASPTGTPSRAS---PTGSPSTASLTGLSSTASPTG--------TPPRAS 393
Query: 1052 THGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVS 1111
G S AS+ PR + G +S SI+ +S + T PR + G
Sbjct: 394 PTGTPSTASL---------TRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPTGTPP 444
Query: 1112 NASIRVGENVSDVAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISL 1171
AS + + T+ + G S AS + + + R + S AS++
Sbjct: 445 RASPTGTPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTK 504
Query: 1172 GESVSDMA--PAR--PRWNTH--------------GHVSDASISLGESVSDMA--PTRPR 1211
ES + + P+R P W G S A+++ S + + P+R
Sbjct: 505 MESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALTRTPSRASLTRTPSRAS 564
Query: 1212 WNTHGHVSDTSIRVGENVSDVAP------IRSRCNTHGHVSDASISLGEPVSDVVSTRPR 1265
T S T ++ + P + SR + G S A ++ + + + T PR
Sbjct: 565 LTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTKMDSTASITRTPPR 624
Query: 1266 WNTHVPIP-------PPHMVLGALSPEAEPNTPRPQQSPPGHTSQSA 1305
+ P PP P A P P+ SP G S+++
Sbjct: 625 ASPTETPPRASPTGTPPRASPTGTPPRASPTGTPPRASPTGTPSRAS 671
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 59.3 bits (142), Expect = 3e-08
Identities = 52/208 (25%), Positives = 96/208 (46%), Gaps = 22/208 (10%)
Query: 618 DVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAR 677
D+P+ + +LE+L+++EK A + + R A + +EE+ R E R
Sbjct: 705 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--------ELR 756
Query: 678 EAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARE 737
+L + + R + +R+Q + L+ Q ++ R+ +EE R
Sbjct: 757 RQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRR 816
Query: 738 LRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRL----ESARLR 793
L +R R EE ER+ ++ L+ + +A+ AR E++A R++ +RL E+ARLR
Sbjct: 817 LEERRR------EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 870
Query: 794 FLLEDEK----HIQEMLKAVSEAHQPQE 817
E+ K +Q + + + Q QE
Sbjct: 871 HEEEERKRKELEVQRQKELMRQRQQQQE 898
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 59.3 bits (142), Expect = 3e-08
Identities = 52/208 (25%), Positives = 96/208 (46%), Gaps = 22/208 (10%)
Query: 618 DVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAR 677
D+P+ + +LE+L+++EK A + + R A + +EE+ R E R
Sbjct: 732 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--------ELR 783
Query: 678 EAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARE 737
+L + + R + +R+Q + L+ Q ++ R+ +EE R
Sbjct: 784 RQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRR 843
Query: 738 LRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRL----ESARLR 793
L +R R EE ER+ ++ L+ + +A+ AR E++A R++ +RL E+ARLR
Sbjct: 844 LEERRR------EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 897
Query: 794 FLLEDEK----HIQEMLKAVSEAHQPQE 817
E+ K +Q + + + Q QE
Sbjct: 898 HEEEERKRKELEVQRQKELMRQRQQQQE 925
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 59.3 bits (142), Expect = 3e-08
Identities = 52/208 (25%), Positives = 96/208 (46%), Gaps = 22/208 (10%)
Query: 618 DVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAR 677
D+P+ + +LE+L+++EK A + + R A + +EE+ R E R
Sbjct: 711 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--------ELR 762
Query: 678 EAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARE 737
+L + + R + +R+Q + L+ Q ++ R+ +EE R
Sbjct: 763 RQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRR 822
Query: 738 LRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRL----ESARLR 793
L +R R EE ER+ ++ L+ + +A+ AR E++A R++ +RL E+ARLR
Sbjct: 823 LEERRR------EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 794 FLLEDEK----HIQEMLKAVSEAHQPQE 817
E+ K +Q + + + Q QE
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQE 904
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 59.3 bits (142), Expect = 3e-08
Identities = 52/208 (25%), Positives = 96/208 (46%), Gaps = 22/208 (10%)
Query: 618 DVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAR 677
D+P+ + +LE+L+++EK A + + R A + +EE+ R E R
Sbjct: 711 DLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE--------ELR 762
Query: 678 EAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARE 737
+L + + R + +R+Q + L+ Q ++ R+ +EE R
Sbjct: 763 RQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRR 822
Query: 738 LRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRL----ESARLR 793
L +R R EE ER+ ++ L+ + +A+ AR E++A R++ +RL E+ARLR
Sbjct: 823 LEERRR------EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 794 FLLEDEK----HIQEMLKAVSEAHQPQE 817
E+ K +Q + + + Q QE
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQE 904
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 57.8 bits (138), Expect = 1e-07
Identities = 87/412 (21%), Positives = 154/412 (37%), Gaps = 58/412 (14%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL-- 748
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 749 ----------EEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLE- 797
EE++ R+ + +H + EQ+ L +Q+ L L LLE
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEY 475
Query: 798 DEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDG 857
K ++E +A Q ++ D L+S+ Q P + G + PAW
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW-A 534
Query: 858 WNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPL 917
P L+ + P + Q +G F ++L++ P + S T P
Sbjct: 535 KEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPP 593
Query: 918 LEVALQTINL--------DLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGP 969
L ++ + D+PP P +T + PA+A +PG
Sbjct: 594 LPTRIEKFDRSSWLRQEEDIPPKVPQR-----------------TTSISPALARKNSPGN 636
Query: 970 LQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQV 1029
A LGS ++ + E +L S P +R + SS T
Sbjct: 637 GSALGPRLGSQPIRASNPDLRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSS 687
Query: 1030 SGGGLPTGDYASEIAPTRPRWNTHGHVS------DASIRVGENVSDVAPTQP 1075
GG P G A TR R N+ S A ++ E+ P++P
Sbjct: 688 QGGSQP-GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 738
Score = 35.4 bits (80), Expect = 0.51
Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 12/123 (9%)
Query: 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSD 689
LEE + EK+ R +R + +EE+ R E +QE I E R L L
Sbjct: 405 LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE-HEQEYIRRQLEEEQRQLEILQQ 463
Query: 690 RQMSERMALDARKREQFQRLKEQFVKDQERRQAAR-QEELDDDFSYARELRDRERRLKSL 748
+ + E+ L KR+Q +E+RQA R Q +L + Y L+ + + + +
Sbjct: 464 QLLHEQALLLEYKRKQL----------EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 513
Query: 749 EEE 751
E++
Sbjct: 514 EKK 516
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 57.8 bits (138), Expect = 1e-07
Identities = 87/412 (21%), Positives = 154/412 (37%), Gaps = 58/412 (14%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL-- 748
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 749 ----------EEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLE- 797
EE++ R+ + +H + EQ+ L +Q+ L L LLE
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEY 475
Query: 798 DEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDG 857
K ++E +A Q ++ D L+S+ Q P + G + PAW
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW-A 534
Query: 858 WNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPL 917
P L+ + P + Q +G F ++L++ P + S T P
Sbjct: 535 KEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPP 593
Query: 918 LEVALQTINL--------DLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGP 969
L ++ + D+PP P +T + PA+A +PG
Sbjct: 594 LPTRIEKFDRSSWLRQEEDIPPKVPQR-----------------TTSISPALARKNSPGN 636
Query: 970 LQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQV 1029
A LGS ++ + E +L S P +R + SS T
Sbjct: 637 GSALGPRLGSQPIRASNPDLRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSS 687
Query: 1030 SGGGLPTGDYASEIAPTRPRWNTHGHVS------DASIRVGENVSDVAPTQP 1075
GG P G A TR R N+ S A ++ E+ P++P
Sbjct: 688 QGGSQP-GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 738
Score = 35.4 bits (80), Expect = 0.51
Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 12/123 (9%)
Query: 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSD 689
LEE + EK+ R +R + +EE+ R E +QE I E R L L
Sbjct: 405 LEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE-HEQEYIRRQLEEEQRQLEILQQ 463
Query: 690 RQMSERMALDARKREQFQRLKEQFVKDQERRQAAR-QEELDDDFSYARELRDRERRLKSL 748
+ + E+ L KR+Q +E+RQA R Q +L + Y L+ + + + +
Sbjct: 464 QLLHEQALLLEYKRKQL----------EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 513
Query: 749 EEE 751
E++
Sbjct: 514 EKK 516
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 57.4 bits (137), Expect = 1e-07
Identities = 87/399 (21%), Positives = 151/399 (37%), Gaps = 61/399 (15%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEE 750
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L +
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 751 ELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVS 810
+ ER+ R+ HY E RRE++ R H E R K ++E +A
Sbjct: 418 QQEREQRR----HYE----EQMRREEER--RRAEHEQEYKR--------KQLEEQRQAER 459
Query: 811 EAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLK 870
Q ++ D L+S+ Q P + G + PAW P L+ +
Sbjct: 460 LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW-AKEIPHLVAVKSQG 518
Query: 871 PLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINL--- 927
P + Q +G F ++L++ P + S T P L ++ +
Sbjct: 519 PALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPPLPTRIEKFDRSSW 577
Query: 928 -----DLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGL 982
D+PP P +T + PA+A +PG A LGS +
Sbjct: 578 LRQEEDIPPKVPQR-----------------TTSISPALARKNSPGNGSALGPRLGSQPI 620
Query: 983 QLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASE 1042
+ + E +L S P +R + SS T GG P G A
Sbjct: 621 RASNPDLRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSSQGGSQP-GSQAGS 670
Query: 1043 IAPTRPRWNTHGHVS------DASIRVGENVSDVAPTQP 1075
TR R N+ S A ++ E+ P++P
Sbjct: 671 SERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 709
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 57.4 bits (137), Expect = 1e-07
Identities = 87/399 (21%), Positives = 151/399 (37%), Gaps = 61/399 (15%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEE 750
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L +
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 751 ELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVS 810
+ ER+ R+ HY E RRE++ R H E R K ++E +A
Sbjct: 418 QQEREQRR----HYE----EQMRREEER--RRAEHEQEYKR--------KQLEEQRQAER 459
Query: 811 EAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLK 870
Q ++ D L+S+ Q P + G + PAW P L+ +
Sbjct: 460 LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW-AKEIPHLVAVKSQG 518
Query: 871 PLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINL--- 927
P + Q +G F ++L++ P + S T P L ++ +
Sbjct: 519 PALTASQSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPPLPTRIEKFDRSSW 577
Query: 928 -----DLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGL 982
D+PP P +T + PA+A +PG A LGS +
Sbjct: 578 LRQEEDIPPKVPQR-----------------TTSISPALARKNSPGNGSALGPRLGSQPI 620
Query: 983 QLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASE 1042
+ + E +L S P +R + SS T GG P G A
Sbjct: 621 RASNPDLRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSSQGGSQP-GSQAGS 670
Query: 1043 IAPTRPRWNTHGHVS------DASIRVGENVSDVAPTQP 1075
TR R N+ S A ++ E+ P++P
Sbjct: 671 SERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 709
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 55.1 bits (131), Expect = 6e-07
Identities = 64/263 (24%), Positives = 107/263 (40%), Gaps = 32/263 (12%)
Query: 656 VSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVK 715
+ +E KE + +Q+L+ +E R + ++ER +++EQ +RL+EQ +
Sbjct: 359 LQQENKERSEALRRQQLL---QEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 716 DQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARRE 775
++E R+ +E+ + R L + ERR K EE + + V+ + E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475
Query: 776 QKALWRIQRHRLESARLRFLLEDEKH------------IQEMLKAVSEAHQPQ---EPPD 820
Q+ L +Q+ L+ + LL D + QE K A +P+ EP D
Sbjct: 476 QRHLEVLQQQLLQEQAM--LLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPAD 533
Query: 821 VLLSVHPQVTSPGP-----EHPEGGQGCDSGSAEQHSPAWD-----GWNRPGLLTPQPLK 870
V + TS P + P G G + A Q + W R L P+P
Sbjct: 534 RAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGS 593
Query: 871 PLAVGAGGRGLQQAEGARPFSDS 893
+ G+ G Q G+ P S S
Sbjct: 594 GSSSGSSNSGSQ--PGSHPGSQS 614
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 54.7 bits (130), Expect = 8e-07
Identities = 97/453 (21%), Positives = 176/453 (38%), Gaps = 76/453 (16%)
Query: 659 EEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQE 718
EE + ++ +Q+ I +E R L ++Q E+ ++REQ + +EQ +++E
Sbjct: 381 EEHKRQLLAERQKRIEEQKEQRRR----LEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 719 RRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKA 778
RR+A ++E R+L + +R+L+ L+++L + QAL+ Y + E R+ ++
Sbjct: 437 RRRAEHEQEY-----IRRQLEEEQRQLEILQQQLLHE--QALLLEYKRKQLEEQRQAERL 489
Query: 779 LWRIQRHRLESARLRFLLEDEKHIQEM-LKAVSEAHQPQEPPDVLLSVHP-----QVTSP 832
++++ R L+ ++++ +++ L E P E P V + +SP
Sbjct: 490 QRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSP 549
Query: 833 GPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKP--------LAVGAGGRGL--- 881
H + D + +P TP L+P +AV + G L
Sbjct: 550 AMPHKVANRISDPNLPPRSESFSISGVQPA-RTPPMLRPVDPQIPHLVAVKSQGPALTAS 608
Query: 882 -----QQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINL--------D 928
Q +G F ++L++ P + S T P L ++ + D
Sbjct: 609 QSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPPLPTRIEKFDRSSWLRQEED 667
Query: 929 LPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDS 988
+PP P +T + PA+A +PG A LGS ++
Sbjct: 668 IPPKVPQR-----------------TTSISPALARKNSPGNGSALGPRLGSQPIRASNPD 710
Query: 989 CGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRP 1048
+ E +L S P +R + SS T GG P G A TR
Sbjct: 711 LRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSSQGGSQP-GSQAGSSERTRV 760
Query: 1049 RWNTHGHVS------DASIRVGENVSDVAPTQP 1075
R N+ S A ++ E+ P++P
Sbjct: 761 RANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 793
Score = 48.1 bits (113), Expect = 8e-05
Identities = 39/178 (21%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL-- 748
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 749 ----------EEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLE- 797
EE++ R+ + +H + EQ+ L +Q+ L L LLE
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEY 475
Query: 798 DEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAW 855
K ++E +A Q ++ D L+S+ Q P + G + PAW
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW 533
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 54.7 bits (130), Expect = 8e-07
Identities = 97/453 (21%), Positives = 176/453 (38%), Gaps = 76/453 (16%)
Query: 659 EEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQE 718
EE + ++ +Q+ I +E R L ++Q E+ ++REQ + +EQ +++E
Sbjct: 381 EEHKRQLLAERQKRIEEQKEQRRR----LEEQQRREKELRKQQEREQRRHYEEQMRREEE 436
Query: 719 RRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKA 778
RR+A ++E R+L + +R+L+ L+++L + QAL+ Y + E R+ ++
Sbjct: 437 RRRAEHEQEY-----IRRQLEEEQRQLEILQQQLLHE--QALLLEYKRKQLEEQRQAERL 489
Query: 779 LWRIQRHRLESARLRFLLEDEKHIQEM-LKAVSEAHQPQEPPDVLLSVHP-----QVTSP 832
++++ R L+ ++++ +++ L E P E P V + +SP
Sbjct: 490 QRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSP 549
Query: 833 GPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKP--------LAVGAGGRGL--- 881
H + D + +P TP L+P +AV + G L
Sbjct: 550 AMPHKVANRISDPNLPPRSESFSISGVQPA-RTPPMLRPVDPQIPHLVAVKSQGPALTAS 608
Query: 882 -----QQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINL--------D 928
Q +G F ++L++ P + S T P L ++ + D
Sbjct: 609 QSVHEQPTKGLSGFQEALNVTSHRVEMP-RQNSDPTSENPPLPTRIEKFDRSSWLRQEED 667
Query: 929 LPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDS 988
+PP P +T + PA+A +PG A LGS ++
Sbjct: 668 IPPKVPQR-----------------TTSISPALARKNSPGNGSALGPRLGSQPIRASNPD 710
Query: 989 CGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRP 1048
+ E +L S P +R + SS T GG P G A TR
Sbjct: 711 LRR--------TEPILES-PLQRTSSGSSSSSSTPSSQPSSQGGSQP-GSQAGSSERTRV 760
Query: 1049 RWNTHGHVS------DASIRVGENVSDVAPTQP 1075
R N+ S A ++ E+ P++P
Sbjct: 761 RANSKSEGSPVLPHEPAKVKPEESRDITRPSRP 793
Score = 48.1 bits (113), Expect = 8e-05
Identities = 39/178 (21%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL-- 748
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 749 ----------EEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLE- 797
EE++ R+ + +H + EQ+ L +Q+ L L LLE
Sbjct: 418 QQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEY 475
Query: 798 DEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAW 855
K ++E +A Q ++ D L+S+ Q P + G + PAW
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAW 533
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 53.9 bits (128), Expect = 1e-06
Identities = 50/214 (23%), Positives = 94/214 (43%), Gaps = 17/214 (7%)
Query: 656 VSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVK 715
+ +E KE + +Q+L+ +E R + ++ER +++EQ +RL+EQ +
Sbjct: 359 LQQENKERSEALRRQQLL---QEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 716 DQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARRE 775
++E R+ +E+ + R L + ERR K EE + + V+ + E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475
Query: 776 QKALWRIQRHRLESARLRFLLEDE-KHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGP 834
Q+ L +Q+ L+ + LLE + ++E +A Q Q+ LLS+ P P
Sbjct: 476 QRHLEVLQQQLLQEQAM--LLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHP 533
Query: 835 EHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQP 868
+H ++Q P ++P P+P
Sbjct: 534 QH-----------SQQPPPPQQERSKPSFHAPEP 556
Score = 47.4 bits (111), Expect = 1e-04
Identities = 81/339 (23%), Positives = 138/339 (40%), Gaps = 33/339 (9%)
Query: 646 RMERVARHSSVSKEEKELRMEIA-KQELIAHAREAASRVLSALSDRQMSERMALDARKRE 704
R +++ + + ++E+ R +A +Q+ I +E R L ++Q ER A R++E
Sbjct: 371 RRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR----LEEQQRREREA--RRQQE 424
Query: 705 QFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHY 764
+ QR +EQ K + R++E ++ E R ER + + +LE + R V
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 765 SKLSAEAARREQKALWRIQRHRLESARLRFLLEDEK----HIQEMLKAVSEAHQPQEPPD 820
L +A E + WR ++ RL+ L+ E+ +Q + H Q PP
Sbjct: 485 QLLQEQAMLLECR--WREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPP 542
Query: 821 VLLSVHPQVTSPGPE-HPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGR 879
P +P P+ H E A++ D + + +P+ GR
Sbjct: 543 QQERSKPSFHAPEPKAHYE--------PADRAREVEDRFRKTNHSSPEAQSKQT----GR 590
Query: 880 GLQQAEGARPFSDSLSIGDFLPVGPG----AEPSVQTGMVPLLEVALQTINLDLPPSAPG 935
L+ +R S+S S G+ V P AEP VQ + L+ + ++ S P
Sbjct: 591 VLEPPVPSR--SESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPS 648
Query: 936 EAPAAASTQPSRPQEYDFSTVL-RPAVATSPAPGPLQAA 973
A + P S VL + + + S AP P Q A
Sbjct: 649 PKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKA 687
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 52.8 bits (125), Expect = 3e-06
Identities = 50/197 (25%), Positives = 91/197 (46%), Gaps = 16/197 (8%)
Query: 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEI---AKQELIAHAREAASRVLSAL 687
EE +E ++ + R + R + ++E+E R++ ++Q+L E ++L
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 688 SDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSY------ARELRDR 741
++++ + KREQ +R + +++ERRQ + E ++ L
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 742 ERRLKSLE-EELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEK 800
ERR + L+ EE E + RQ L+ S E R Q+ L R Q+ R E RL+ E+E+
Sbjct: 614 ERREQRLKREEPEEERRQQLLK-----SEEQEERRQQQLRREQQERREQ-RLKREEEEER 667
Query: 801 HIQEMLKAVSEAHQPQE 817
Q + + E + QE
Sbjct: 668 LEQRLKREHEEERREQE 684
Score = 48.9 bits (115), Expect = 4e-05
Identities = 45/175 (25%), Positives = 83/175 (47%), Gaps = 9/175 (5%)
Query: 659 EEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQE 718
EE++LR E +Q+L R+ R L RQ E L +++ ++ R +EQ +++E
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQL--RQEREEQQLRSQESDRKFREEEQLRQERE 1808
Query: 719 RRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKA 778
+Q R ++ D + + E E + + L +E +R+ R + ++ + E +RRE++
Sbjct: 1809 EQQL-RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE--EQFA--TQEKSRREEQE 1863
Query: 779 LWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPG 833
LW+ + + R R L E+ HI+ K Q E H ++ PG
Sbjct: 1864 LWQEEEQKRRQERERKLREE--HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPG 1916
Score = 48.1 bits (113), Expect = 8e-05
Identities = 45/202 (22%), Positives = 87/202 (43%), Gaps = 12/202 (5%)
Query: 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDR 690
+ LK +++ + + E R + +E++E + K+E + + R +
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELR---DRERRLKS 747
ER + EQ +R ++Q ++Q+ R+ R + +++ + L+ + ERR +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 748 LEEELERKARQALVDHYSK----LSAEAARREQKALWRI-----QRHRLESARLRFLLED 798
L EE + +AR+ + K L +EA R+ K R QR R E R E
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 799 EKHIQEMLKAVSEAHQPQEPPD 820
E QE +A + + ++ D
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRD 766
Score = 47.8 bits (112), Expect = 1e-04
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 25/202 (12%)
Query: 627 IFSLEELKEIEKDCAVYVGRMERVA-----RHSSVSKEEKELRMEIAKQELIAHAREAAS 681
+F EE KE K V E++ R + +EE++LR ++ +QEL +E
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR-KLERQELRRERQEEEQ 295
Query: 682 RVLSALSDRQM------------SERMALDARKREQFQRLKEQFVKDQERR---QAARQE 726
+ ++Q+ ER R+ +Q +R ++Q ++QE R Q R++
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 727 ELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHR 786
E + R ++ ERR + L E + + Q L + RREQ+ Q R
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 787 LESAR----LRFLLEDEKHIQE 804
+ R LR E+E+H Q+
Sbjct: 416 EQQLRREQQLRREQEEERHEQK 437
Score = 47.8 bits (112), Expect = 1e-04
Identities = 44/179 (24%), Positives = 82/179 (45%), Gaps = 14/179 (7%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQ-MSERMALDARKREQF 706
ER R + +EE+ + E +Q+L E + L + + + +R+ + + R +
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 707 QRLKEQFVKDQERR---QAARQEELDDDFSYARE---LRDRERRLKSLEEELERKARQAL 760
+ +EQ +K +E + Q R++ L + R+ R+ ERR + L+ E E + Q L
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 761 VDHYSKLSAEAARREQKALWRIQRHRLESARLRFLL---EDEKHIQEMLKAVSEAHQPQ 816
+ + RREQ R++R E R + LL E E+ Q+ L+ + + Q
Sbjct: 603 KREEVERLEQEERREQ----RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Score = 47.4 bits (111), Expect = 1e-04
Identities = 44/172 (25%), Positives = 83/172 (48%), Gaps = 13/172 (7%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIA-HAREAASRVLSALSDRQMSERMAL--DARKRE 704
E+ R + +E++E R + ++E H +E + L + + ER + +RE
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 705 QFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHY 764
Q +R ++Q ++QE R+ R + +++ + LR E++L+ +EE R+ L+
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRS-EQQLRREQEE----RREQLLKRE 553
Query: 765 SKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQ 816
+ E RREQ R++R + E R + L +E+ Q+ LK E Q
Sbjct: 554 EEKRLEQERREQ----RLKREQ-EERRDQLLKREEERRQQRLKREQEERLEQ 600
Score = 46.6 bits (109), Expect = 2e-04
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 634 KEIEKDCAVYVGRMERVARHSSVSK--EEKELRMEIAKQELIAHAREAASRVLSALSDRQ 691
K +E++ + E+ RH K EE++L E +Q+L R+ R RQ
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 692 MSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEE 751
ER L ++ + Q L+ +F ++++ RQ QE+L Y + L + + R + E++
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 752 LERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEK 800
L R+ R +L E ++ ++ ++ R E +LR E+++
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR-EEEQLRQEREEQQ 1811
Score = 45.4 bits (106), Expect = 5e-04
Identities = 42/170 (24%), Positives = 77/170 (45%), Gaps = 27/170 (15%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
++E+E R + Q E + LSA + L A +R+Q + ++F+ ++
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE---QRFLPEE 814
Query: 718 ERRQAARQEELDDDFSYARELRDRERRLKSLEEE--LERKAR--------QALVDHYSKL 767
E ++ R R+ R+RE+ L+ LEEE L+R+ R L + +
Sbjct: 815 EEKEQRR-----------RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 768 SAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQE 817
++ RR+QK W+++ R R R L + +QE L+ + Q +E
Sbjct: 864 RSQEQRRDQKWRWQLEEER---KRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Score = 45.1 bits (105), Expect = 6e-04
Identities = 39/179 (21%), Positives = 78/179 (43%), Gaps = 10/179 (5%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQ 705
R +++ R + +E++ R + ++ H +E + L + + + +R +
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 706 FQRLKEQFVKDQERRQAARQEELDDDFSYARELR--------DRERRLKSLEEELERKAR 757
+R K+Q +DQE + R +L+++ ++ R ERR + L+ + E +
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Query: 758 QALVDHYSKLSAEAARREQKALWRIQRHRLESAR--LRFLLEDEKHIQEMLKAVSEAHQ 814
Q + +L E R ++ L R + RLE R R E E+ ++LK E Q
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587
Score = 44.7 bits (104), Expect = 8e-04
Identities = 34/155 (21%), Positives = 73/155 (47%), Gaps = 8/155 (5%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
+EE++LR E +Q+L R+ R+ RQ ER ++ ++ + Q ++Q +++
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 718 ERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDH--------YSKLSA 769
+R+ ++ L + ++R+R+ E +L R+ R+ + H +L
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 770 EAARREQKALWRIQRHRLESARLRFLLEDEKHIQE 804
E ++ + R ++ R E +LR + K +QE
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Score = 43.5 bits (101), Expect = 0.002
Identities = 44/191 (23%), Positives = 86/191 (45%), Gaps = 27/191 (14%)
Query: 646 RMERVARHSSVSKEEKELRME---IAKQELIAHAREAASRVLSALSDRQMSERMAL-DAR 701
R ER ++ +EE+EL+ E + ++E R+ R + Q E L + R
Sbjct: 983 RQEREKKY----REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 702 KREQFQRLKEQFVKDQE-----------RRQAARQEELDDDFSYARELRDRERRLKSLEE 750
++ + Q + Q+ +++E R+ R++EL+ + EL+ E +L L E
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL--LRE 1096
Query: 751 ELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQ----EML 806
E E++ RQ + E ++E++ L R +R + L +E+ +Q ++L
Sbjct: 1097 EPEKRRRQERERQCRE--EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 807 KAVSEAHQPQE 817
+ E + QE
Sbjct: 1155 REEPEKRRRQE 1165
Score = 43.5 bits (101), Expect = 0.002
Identities = 48/176 (27%), Positives = 79/176 (44%), Gaps = 28/176 (15%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQ 707
E++ ++ +EL + K+E + E R RQ ER R+ E+ Q
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC---REEEELQ 1117
Query: 708 RLKEQFVKDQERRQAARQEELDDDFSYARELRDRE----------RRLKSL------EEE 751
+ +EQ ++ E R+ R++EL+ + E++ E RR + L EEE
Sbjct: 1118 QEEEQLLR--EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 752 LERKARQALVDHYSKLSAEAAR--REQKALW---RIQRHRLESAR--LRFLLEDEK 800
L+++ Q L + K E R RE++ L R QR+R E R L++ E EK
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Score = 42.7 bits (99), Expect = 0.003
Identities = 45/165 (27%), Positives = 78/165 (47%), Gaps = 11/165 (6%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
+E +E + E +Q+L RE R L Q ER R+ ++ +R ++Q ++Q
Sbjct: 325 QERREQQEERREQQL---RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 718 ERR---QAARQEELDDDFSYARELRDRERRLKSLEEEL--ERKARQALVDHYSKLSAEAA 772
+ R Q R+++L + RE + R + E++L E++ R+ + + E
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 773 RREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQE 817
RREQ+ L R Q R + L+ E E+H QE K + Q +E
Sbjct: 442 RREQR-LKREQEERRD--WLKREEETERHEQERRKQQLKRDQEEE 483
Score = 41.2 bits (95), Expect = 0.009
Identities = 43/176 (24%), Positives = 79/176 (44%), Gaps = 17/176 (9%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQ 705
++ R R +EE++LR +QEL RE RQ +E+ L R++E+
Sbjct: 1699 QLRRQERERKFLQEEQQLR----RQELERKFREEEQL-------RQETEQEQL--RRQER 1745
Query: 706 FQR-LKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKAR--QALVD 762
+++ L+E+ ++ + Q R++E D F +LR + +E +RK R + L
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 763 HYSKLSAEAARREQKALWRIQRHRLESARLRFLLE-DEKHIQEMLKAVSEAHQPQE 817
+ +R+ K W ++ +LE R E D ++ E A E + +E
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Score = 40.8 bits (94), Expect = 0.012
Identities = 45/165 (27%), Positives = 77/165 (46%), Gaps = 22/165 (13%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSAL---SDRQMSERMALDARK 702
++ R R +EE +LR + +Q+L H R+ R L + Q R D +
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQL-RHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 703 REQFQRLKEQFVKDQERR-----QAARQEELDDDFSYARELRDRERRLKSLEEELERKAR 757
RE+ Q+L+ Q ++ER+ Q R++EL+ F +LR +E+L R+ R
Sbjct: 1694 REEEQQLRRQ---ERERKFLQEEQQLRRQELERKFREEEQLRQETE-----QEQLRRQER 1745
Query: 758 QALVDHYSKLSAEAARREQKALWRIQRHR--LESARLRFLLEDEK 800
+ +L E RE++ L R +R R E +LR E+++
Sbjct: 1746 YRKILEEEQLRPE---REEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Score = 40.4 bits (93), Expect = 0.016
Identities = 37/156 (23%), Positives = 71/156 (45%), Gaps = 7/156 (4%)
Query: 649 RVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQR 708
R RH +EE++L E +Q+L H +E R L + Q R D + REQ R
Sbjct: 1456 RQERHRKF-REEEQLLQEREEQQL--HRQE---RDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 709 LKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLS 768
+E K E Q +++ F + R+ R + ++ +RK R+ +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE 1569
Query: 769 AEAARREQKALWRIQRHRL-ESARLRFLLEDEKHIQ 803
+ +R+E+ +R++ ++ + R +EDE+ ++
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Score = 40.0 bits (92), Expect = 0.021
Identities = 42/173 (24%), Positives = 74/173 (42%), Gaps = 14/173 (8%)
Query: 652 RHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKE 711
R + +E++E R + ++E RE R R+ E +REQ R ++
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLR-------REQEEERREQQLRREQQLRREQ 387
Query: 712 QFVKDQERR---QAARQEELDDDFSYAREL---RDRERRLKSLEEELERKARQALVDHYS 765
Q ++Q+ R Q R+++L + RE R+++ R + EE E+K Q +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 766 KLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQE-MLKAVSEAHQPQE 817
K E R K +RH E + + + E+ +E LK E + Q+
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Score = 39.3 bits (90), Expect = 0.035
Identities = 48/200 (24%), Positives = 85/200 (42%), Gaps = 34/200 (17%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARK----- 702
ER+ + EE+ E+A++E +A R+ S + Q DAR+
Sbjct: 666 ERLEQRLKREHEEERREQELAEEE----QEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 703 -------------REQFQRLKEQFVKDQERRQAARQEELDD---DFSY---ARELRDRER 743
+E+ +R +E ++ QE +A RQ++ ++ DF++ A E +R R
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 744 RLKSLEEEL-ERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHI 802
+ S L E++ RQ + + E++ R ++ R L+FL E+E+
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-- 839
Query: 803 QEMLKAVSEAHQPQEPPDVL 822
L+ A Q QE D L
Sbjct: 840 ---LQRRERAQQLQEEEDGL 856
Score = 38.5 bits (88), Expect = 0.060
Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 18/181 (9%)
Query: 645 GRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKRE 704
GR AR + E++LR E +Q R L +++ R + K
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQR--------EQRFLPEEEEKEQRRRQRREREKEL 831
Query: 705 QFQRLKEQFVKDQERRQAARQEE--LDDDFSYARELRDRERRLKSLEEELERKARQALVD 762
QF +EQ + +ER Q ++EE L +D R R + + E ERK R+ +
Sbjct: 832 QFLEEEEQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL- 889
Query: 763 HYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVL 822
Y+K + + R+++ L + + L+ +++ QE + E Q Q+ + L
Sbjct: 890 -YAKPALQEQLRKEQQLLQEEEEELQREE-----REKRRRQEQERQYREEEQLQQEEEQL 943
Query: 823 L 823
L
Sbjct: 944 L 944
Score = 38.5 bits (88), Expect = 0.060
Identities = 45/185 (24%), Positives = 81/185 (43%), Gaps = 26/185 (14%)
Query: 646 RMERVARHSSVSKEEKELR--------------------MEIAKQELIAHAREAASRVLS 685
R+ R R KEE++LR ++++QE RE +V
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 686 ALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEE----LDDDFSYARELRDR 741
+R+ E ++R + R +EQ ++++E +Q RQE L+++ R+ RDR
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 742 ERRLKSL-EEELERKARQALVDHYSKLSAEAARREQKALWRIQR-HRLESARLRFLLEDE 799
+ R + L +E ERK + + + +E++ L R +R + R R E+E
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 800 KHIQE 804
+ QE
Sbjct: 1562 QLRQE 1566
Score = 38.1 bits (87), Expect = 0.079
Identities = 44/167 (26%), Positives = 76/167 (45%), Gaps = 11/167 (6%)
Query: 652 RHSSVSKEEKELRMEIAKQELIAHAREAASRVLSAL---SDRQMSERMALDARKREQFQR 708
R S+EEK+L E +++ + R L + Q R D + RE+ R
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 709 LKEQFVKDQERRQAARQEELDDDF-SYARELRDRERRLKSLEEELERKARQALVDHYSKL 767
+EQ K E Q R++E + F ++LR +ER + L ++ +RK R + +L
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE-QQLRQDRDRKFR----EEEQQL 1423
Query: 768 SAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQ 814
S + R++K Q+ R + +FL E+++ QE + E Q
Sbjct: 1424 SRQ--ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Score = 37.7 bits (86), Expect = 0.10
Identities = 46/187 (24%), Positives = 78/187 (41%), Gaps = 20/187 (10%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQ 705
R ER + +E + ++E +E + L + ER + R++
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 706 FQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYS 765
R +EQ + QER + R+EE +++R +ER K LEE E++ RQ +
Sbjct: 1415 KFREEEQQLSRQERDRKFREEE--------QQVRRQERERKFLEE--EQQLRQERHRKFR 1464
Query: 766 KLSAEAARREQKALWRIQRHRL---ESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVL 822
+ RE++ L R +R R E +LR D K ++ L++ QEP
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS-------QEPERKF 1517
Query: 823 LSVHPQV 829
L Q+
Sbjct: 1518 LEEEQQL 1524
Score = 37.0 bits (84), Expect = 0.18
Identities = 45/181 (24%), Positives = 74/181 (40%), Gaps = 14/181 (7%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQ 705
+ ER+ + ++E+ R QE R A L + + E + +R +
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQE--REERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 706 FQRLKEQFVKDQERRQAARQEELDDDFSYA--RELRDRERRLKSLEEELE------RKAR 757
L+ K +E +Q R+E D F +E R RE L+ EE+L+ ++
Sbjct: 215 LLELRR---KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 758 QALVDHYSKLSAEAARRE-QKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQ 816
Q + KL + RRE Q+ + QR R E R E+ + QE + E + Q
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 817 E 817
E
Sbjct: 332 E 332
Score = 37.0 bits (84), Expect = 0.18
Identities = 37/173 (21%), Positives = 77/173 (44%), Gaps = 19/173 (10%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
+ E+E ++ ++E RE A ++ Q + R+R Q QR +++
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE-----RRRSQEQRRDQKWRWQL 878
Query: 718 ERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQK 777
E + R+ L + +LR ++ L+ EEEL+R+ R+ + R+EQ+
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE-----------KRRRQEQE 927
Query: 778 ALWRIQRHRLESARLRFLLE--DEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQ 828
+R + +L+ + L E +++ QE + + + Q+ + LL P+
Sbjct: 928 RQYR-EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Score = 37.0 bits (84), Expect = 0.18
Identities = 29/119 (24%), Positives = 58/119 (48%), Gaps = 5/119 (4%)
Query: 701 RKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQAL 760
RK +Q + +E+ ++ +ER + RQE+ + + +L+ E +L L EE E++ RQ
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQ-ERQYREEEQLQQEEEQL--LREEREKRRRQER 956
Query: 761 VDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDE--KHIQEMLKAVSEAHQPQE 817
Y K + EQ ++ R + ++ E+E + +++L+ E + QE
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Score = 37.0 bits (84), Expect = 0.18
Identities = 47/203 (23%), Positives = 89/203 (43%), Gaps = 20/203 (9%)
Query: 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDR 690
EEL++ E+ R +EE+EL+ E +++L+ RE R R
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQE--EEQLLREEREKRRRQELERQYR 1141
Query: 691 ------QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERR 744
Q E++ + ++ + Q L+ Q+ +++E Q ++ L ++ R+ R+R+ R
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQY-REEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 745 LKSLEEELERKARQALVDHYSKL------SAEAARREQKALWR----IQRHRLESARLRF 794
+ + +RK R D S L E A R+ K + Q +LE ++LR
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260
Query: 795 LLEDEKHIQEMLKAVSEAHQPQE 817
+ ++ +Q +L E + QE
Sbjct: 1261 -RQSQQDLQHLLGEQQERDREQE 1282
Score = 35.8 bits (81), Expect = 0.39
Identities = 44/196 (22%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 634 KEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMS 693
K +E++ + +R R + +E E + +Q+L H ++ + L +
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL--HRQQRQRKFLQEEQQLRRQ 1543
Query: 694 ERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELE 753
ER + R++ R +EQ +++E +Q +RQE RDR+ RL+ + +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE------------RDRKFRLEEQKVRRQ 1591
Query: 754 RKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAH 813
+ R+ + D EQ+ + + +L R R EDE+ +QE + + H
Sbjct: 1592 EQERKFMED------------EQQLRRQEGQQQLRQERDRKFREDEQLLQE--REEQQLH 1637
Query: 814 QPQEPPDVLLSVHPQV 829
+ QE L PQ+
Sbjct: 1638 R-QERDRKFLEEEPQL 1652
Score = 35.0 bits (79), Expect = 0.67
Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 14/131 (10%)
Query: 659 EEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRL---KEQFVK 715
EE++L E K EA R + ++Q+ + R+R++ R +EQ ++
Sbjct: 1295 EEEQLEREEQK--------EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 716 DQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARRE 775
++E Q R++E D F ELR +E+ K LEEE +R RQ + K + +E
Sbjct: 1347 ERE-EQPLRRQERDRKFR-EEELRHQEQGRKFLEEE-QRLRRQERERKFLKEEQQLRCQE 1403
Query: 776 QKALWRIQRHR 786
++ R R R
Sbjct: 1404 REQQLRQDRDR 1414
Score = 34.3 bits (77), Expect = 1.1
Identities = 47/181 (25%), Positives = 85/181 (46%), Gaps = 36/181 (19%)
Query: 652 RHSSVSKE--EKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRL 709
RH+ +K +++LR E Q+L+ E R RQ ER R+ EQ Q+
Sbjct: 886 RHTLYAKPALQEQLRKE---QQLLQEEEEELQREEREKRRRQEQERQY---REEEQLQQE 939
Query: 710 KEQFVKDQERRQAARQEELDDDFSYARELRDR----ERRLKSLEEEL-----ERKARQAL 760
+EQ +++ ER + RQE R+R +++L+ EE+L E++ RQ
Sbjct: 940 EEQLLRE-EREKRRRQE------------RERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Query: 761 VDHYSKLSAEAARREQKALWRIQR--HRLESARLRFLLEDE--KHIQEMLKAVSEAHQPQ 816
Y + E ++E++ L R +R R + ++ +DE + +++L+ E + Q
Sbjct: 987 EKKYRE--EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 817 E 817
E
Sbjct: 1045 E 1045
Score = 33.1 bits (74), Expect = 2.5
Identities = 30/129 (23%), Positives = 51/129 (39%), Gaps = 11/129 (8%)
Query: 692 MSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEE 751
+ + LD KR + KE ++D RRQ Q + E + RR K E+E
Sbjct: 89 LGQATGLDEEKRARCDG-KESLLQD--RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE 145
Query: 752 LERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSE 811
E + + +L +R + LWR ++ E +E+ +E +
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE--------REERRAEEEQLQSCK 197
Query: 812 AHQPQEPPD 820
H+ +E PD
Sbjct: 198 GHETEEFPD 206
Score = 32.7 bits (73), Expect = 3.3
Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 689 DRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL 748
DR E L+ RE+ + K + K QE +Q R+E + R ++ +R+ +
Sbjct: 1290 DRHFPEEEQLE---REEQKEAKRRDRKSQEEKQLLREEREE-----KRRRQETDRKFREE 1341
Query: 749 EEELERKARQAL--VDHYSKLSAEAARREQ---KALWRIQRHRLESARLRFLLEDEK 800
E+ L+ + Q L + K E R ++ K L QR R + +FL E+++
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Score = 32.0 bits (71), Expect = 5.6
Identities = 36/165 (21%), Positives = 75/165 (45%), Gaps = 14/165 (8%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
+EE+EL+ E +++L+ +E + +RQ E L +KR+Q R ++Q +
Sbjct: 1171 REEEELQQE--EEQLLREEQEKRRQE----RERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 718 ERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQK 777
+ + ++ + D+ Y + R+ E+ + + +L + Q + H E R +++
Sbjct: 1225 WQWEPEKENAVRDNKVYCKG-RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 778 ALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVL 822
W+ QR R F E++ +E +A + QE +L
Sbjct: 1284 RRWQ-QRDR------HFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Score = 31.2 bits (69), Expect = 9.6
Identities = 36/168 (21%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 635 EIEKDCAVYVGRMERVARHSSVSK--EEKELRMEIAKQELIAHAREAASRVLSALSDRQM 692
E EK+ AV ++ R + + E+ +LR ++Q+L E R DR+
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER------DREQ 1281
Query: 693 SERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEEL 752
R ++R++ +EQ +++++ R + ++ RE R+ +RR +E
Sbjct: 1282 ERRRW---QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR----RQET 1334
Query: 753 ERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEK 800
+RK R+ + R+E+ +R + R + +FL E+++
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 50.8 bits (120), Expect = 1e-05
Identities = 44/192 (22%), Positives = 90/192 (46%), Gaps = 10/192 (5%)
Query: 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSD 689
++E +E ++ + E R EKE +M +QE + +E R L +
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR--RQEEMMWEKEEKMRRLEEMMW 373
Query: 690 RQMSERMALDARKREQFQRLKEQFVKDQE----RRQAARQEELDDDFSYARELRDRERRL 745
+ + L+ + EQ ++++EQ K QE R Q RQE+ + ++R++E ++
Sbjct: 374 EKEEKIRELEEKMHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432
Query: 746 KSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEM 805
+ E+++ R+ + + K+ E R+EQ+ +WR Q ++ + +++ H QE
Sbjct: 433 REQEKKMWRQEEK--IHEQEKIREEEKRQEQEEMWR-QEEKIREQEEIWRQKEKMHEQEK 489
Query: 806 LKAVSEAHQPQE 817
++ E QE
Sbjct: 490 IRKQEEKVWRQE 501
Score = 41.6 bits (96), Expect = 0.007
Identities = 38/203 (18%), Positives = 93/203 (45%), Gaps = 16/203 (7%)
Query: 644 VGRMERVARHSSVSKEEKELRME---IAKQELIAHAREAASRVLSALSDRQMSERMALDA 700
+ E + R E++++R + + +QE H +E R RQ + +
Sbjct: 471 IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 701 RKREQFQRLKEQ--FVKDQERRQAARQEELDDDFSYARE---LRDRERRLKSLEEELERK 755
+ REQ ++++EQ +++QE + ++E++ + R+ +R++E +++ +E++ R+
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI-RE 589
Query: 756 ARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQP 815
+ + + K+ REQ+ + + Q ++ + + E E+ +QE + + +
Sbjct: 590 QEEKIWEQEEKI------REQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEK 642
Query: 816 QEPPDVLLSVHPQVTSPGPEHPE 838
+V L + EH E
Sbjct: 643 MWEQEVRLRQQEEKMQEHQEHLE 665
Score = 38.9 bits (89), Expect = 0.046
Identities = 36/161 (22%), Positives = 71/161 (44%), Gaps = 18/161 (11%)
Query: 658 KEEKELRME--IAKQELIAHAREAASRVLSALSDRQ------MSERMALDARKREQFQRL 709
+EEK R E I +QE +E R + Q E+M + R Q +++
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 710 KEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSA 769
+EQ K +E+++ R++E ++ ++E +++ EE ++ + +
Sbjct: 574 REQEEKIREQKEKIREQE--------EKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625
Query: 770 EAARREQKALWRIQRHRLESARLRFLLEDEK--HIQEMLKA 808
E +EQ+ R Q ++ +R ++EK QE L+A
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 34.7 bits (78), Expect = 0.87
Identities = 41/189 (21%), Positives = 78/189 (41%), Gaps = 16/189 (8%)
Query: 631 EELKEIEK--DCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALS 688
E+++E EK + + R E R E+E +M +QE H +E +
Sbjct: 403 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW--RQEEKIHEQEK----IREEE 456
Query: 689 DRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSL 748
RQ E M K + + + Q K E+ + +QEE + ++ D+E +++
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE--KVWRQEEKMHDQEEKIREQ 514
Query: 749 EEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKA 808
EE++ R+ + E REQ+ + + Q ++ E++ QE ++
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ------EEKMQEQEKMRR 568
Query: 809 VSEAHQPQE 817
E + QE
Sbjct: 569 QEEKIREQE 577
Score = 34.3 bits (77), Expect = 1.1
Identities = 35/164 (21%), Positives = 72/164 (43%), Gaps = 10/164 (6%)
Query: 658 KEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQ 717
+EEK E QE RE ++ + E M + +E+ R +E+ + ++
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE---KEEKMRRQEEMMWEK 361
Query: 718 ERRQAARQEELDDDFSYARELRDR---ERRLKSLEEELERKARQALVDHYSKLSAEAARR 774
E + +E + + REL ++ + +++ E+E +R+ + + + + EA
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIR--EQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 775 EQKALWRIQRHRLESARLRFLLEDEK-HIQEMLKAVSEAHQPQE 817
Q+ R Q ++ + ++EK H QE ++ E Q QE
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE-EEKRQEQE 462
Score = 32.7 bits (73), Expect = 3.3
Identities = 34/160 (21%), Positives = 68/160 (42%), Gaps = 31/160 (19%)
Query: 661 KELRMEIAKQELIAHAREAASRVLSALSD---RQMSERMALDARKREQFQRLKEQFVKDQ 717
KEL+ AK + E +R+ + RQ + + + +EQ ++++EQ K +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 718 ERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQK 777
E+ + R++E + ++E +++ EE + K E RR ++
Sbjct: 332 EQEEKMRRQE--------EMMWEKEEKMRRQEEMMWEK-------------EEKMRRLEE 370
Query: 778 ALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQE 817
+W + E LE++ H QE ++ E Q +E
Sbjct: 371 MMWEKEEKIRE-------LEEKMHEQEKIREQEEKRQEEE 403
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 49.7 bits (117), Expect = 3e-05
Identities = 100/430 (23%), Positives = 163/430 (37%), Gaps = 61/430 (14%)
Query: 681 SRVLSALSDRQMSERMALDARKREQFQRLK----EQFVKDQERRQAARQEELD----DDF 732
S++ + + + E + + R+ ++ QR K E+ +++ R+ +E L+ +
Sbjct: 125 SQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE 184
Query: 733 SYARELRDRERRLKSLEEELERK---ARQALVDHYSKLSAE-AARREQKALWRIQRHRLE 788
+E +RER+ + +E LER+ RQ ++ +L E R+E++ L R++R R E
Sbjct: 185 RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE 244
Query: 789 SARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSA 848
R + LE E+ E + +S A P L SV ++ P G + S
Sbjct: 245 RER-QEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEP-------GLQAASQ 296
Query: 849 EQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEP 908
+P+ G G L P P PL G QA A P P GP P
Sbjct: 297 PAETPSQQGIVL-GPLAPPPPPPLPPGPA-----QASVALP----------PPPGPPPPP 340
Query: 909 SVQTGMVPLLEVALQTINLDLPPSAPGEAP--------AAASTQPSRPQEYDFSTVLRPA 960
+ + P N PP P AP A+ ++ +RP T L A
Sbjct: 341 PLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRP-----LTGLAAA 395
Query: 961 VATSPAPGPLQAAECSLGSSGLQLWEDSC----------GKMDACGSASRETLLPSHPPR 1010
+A + + + S S G + +S G + GS E + R
Sbjct: 396 IAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARR 455
Query: 1011 RAALEEGSSQPTERL--FGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVS 1068
R E+GS+ TE+ G+ S S PTR W ++ + V
Sbjct: 456 RRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRPK 515
Query: 1069 DVAPTQPRWN 1078
+QP N
Sbjct: 516 STPLSQPSAN 525
Score = 43.9 bits (102), Expect = 0.001
Identities = 51/200 (25%), Positives = 84/200 (42%), Gaps = 25/200 (12%)
Query: 647 MERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQF 706
+E R + +KEL E ++E + R R+ +R ER+ + +RE+
Sbjct: 140 LEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER---ERLEQEQLERERQ 196
Query: 707 QRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSK 766
+R +++ ++ QER + + E + R+ R RL+ LE E + + RQ
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-------- 248
Query: 767 LSAEAARREQKALWRIQRHRLESAR--------LRFLLEDEKHIQEMLKAVSE-AHQPQE 817
E REQ W +R R+ SA L +L D + L+A S+ A P +
Sbjct: 249 ---EQLEREQLE-WERER-RISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ 303
Query: 818 PPDVLLSVHPQVTSPGPEHP 837
VL + P P P P
Sbjct: 304 QGIVLGPLAPPPPPPLPPGP 323
>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
Length = 1970
Score = 49.7 bits (117), Expect = 3e-05
Identities = 118/505 (23%), Positives = 169/505 (33%), Gaps = 65/505 (12%)
Query: 902 VGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAV 961
+ P P Q G P ++ + P A G +P+AAS FS P
Sbjct: 1513 ISPAMTPWNQ-GATPAYGAWSPSVGSGMTPGAAGFSPSAASDASG------FSPGYSP-- 1563
Query: 962 ATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQP 1021
A SP PG S GS G S + + G A + PS+ P A E S
Sbjct: 1564 AWSPTPG-------SPGSPG-----PSSPYIPSPGGA----MSPSYSPTSPAYEPRS--- 1604
Query: 1022 TERLFGQVSGGGLPTGDYASEIAPTRPRWN-THGHVSDASIRVGENVSDVAPTQPRWN-T 1079
GG P + +PT P ++ T S S +PT P ++ T
Sbjct: 1605 --------PGGYTP---QSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPT 1653
Query: 1080 HGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWN-THGHVS 1138
S S S + +PT P + S S +PT P ++ T S
Sbjct: 1654 SPSYSPTSPSYSPTSPSYSPTSPSY------SPTSPSYSPTSPSYSPTSPSYSPTSPSYS 1707
Query: 1139 NASIRVGENVSDVAPTRPRWN-THGHVSDASISLGESVSDMAPARPRWN-THGHVSDASI 1196
S +PT P ++ T S S S + + +P P + T S S
Sbjct: 1708 PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSP 1767
Query: 1197 SLGESVSDMAPTRPRWN-THGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEP 1255
S + + PT P ++ T S TS +P R S P
Sbjct: 1768 SYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSP 1827
Query: 1256 VSDVVS-TRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTV 1314
S S T P++ P P SPE P +P+ + P ++ S T
Sbjct: 1828 SSPSYSPTSPKYTPTSPSYSPS------SPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTY 1881
Query: 1315 LDCGPRL-PVEVGPSLSSP-----SSGCGEGSISVGENVSDVAPTQPWW-PNTPGDSVSE 1367
P+ P S +SP S S + +PT P + P +P S
Sbjct: 1882 SPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYS 1941
Query: 1368 ELGPGRSGDTEDLSPNWPLNSQEDT 1392
PG S + S P S +D+
Sbjct: 1942 PTSPGYSPTSPTYSLTSPAISPDDS 1966
Score = 48.5 bits (114), Expect = 6e-05
Identities = 100/475 (21%), Positives = 155/475 (32%), Gaps = 85/475 (17%)
Query: 845 SGSAEQHSPAWDGW-NRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVG 903
SG + +SPAW PG +P P P GG P + S G + P
Sbjct: 1555 SGFSPGYSPAWSPTPGSPG--SPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQS 1612
Query: 904 PGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVAT 963
P P+ + + P++P +P + S P+ P S P T
Sbjct: 1613 PSYSPT---------SPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSP---T 1660
Query: 964 SPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTE 1023
SP+ P + S S PS+ P S PT
Sbjct: 1661 SPSYSPTSPSYSPT-------------------SPSYSPTSPSYSP-----TSPSYSPTS 1696
Query: 1024 RLFGQVSGGGLPTGDYASEIAPTRPRWN-THGHVSDASIRVGENVSDVAPTQPRWN-THG 1081
+ S PT + +PT P ++ T S S +PT P ++ T
Sbjct: 1697 PSYSPTSPSYSPT---SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSP 1753
Query: 1082 HVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWN-THGHVSNA 1140
+ + S S + +PT P + PT P ++ T S
Sbjct: 1754 NYTPTSPSYSPTSPSYSPTSPNY--------------------TPTSPNYSPTSPSYSPT 1793
Query: 1141 SIRVGENVSDVAPTRPRWNTHGHV-SDASISLGESVSDMAPARPRWNTHGHVSDASISLG 1199
S +P+ PR+ + +S S S +P P++ + S S
Sbjct: 1794 SPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKY------TPTSPSYS 1847
Query: 1200 ESVSDMAPTRPRWN-THGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSD 1258
S + PT P+++ T S TS S +P S + + S PV
Sbjct: 1848 PSSPEYTPTSPKYSPTSPKYSPTS----PKYSPTSPTYSPTTPKYSPTSPTYSPTSPV-- 1901
Query: 1259 VVSTRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQST 1313
T P+++ P P SP+ P +P + P ++ S S G T
Sbjct: 1902 YTPTSPKYSPTSPTYSP------TSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPT 1950
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 49.3 bits (116), Expect = 3e-05
Identities = 91/422 (21%), Positives = 157/422 (37%), Gaps = 52/422 (12%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEE 750
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L +
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 751 ELERKARQALVDHY-SKLSAEAARREQKALWRIQRHRLESARLRFLLEDE-KHIQEMLKA 808
+ ER+ R+ HY ++ E RR + +R +LE R L+ + K ++ L +
Sbjct: 418 QQEREQRR----HYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVS 473
Query: 809 VSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSA--EQHSPAWDGWNRPGLLTP 866
+ Q Q P + H + E P + + S Q SPA + P
Sbjct: 474 LQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDP 533
Query: 867 QPLKPLAVGAGGRGLQQAEG---ARPFSDSL-------SIGDFLPVGPGAEPSVQTGMVP 916
L P + G+Q A RP + S G L G+
Sbjct: 534 N-LPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
Query: 917 LLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLR-----------------P 959
E T + P + + P+R +++D S+ LR P
Sbjct: 593 FQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISP 652
Query: 960 AVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSS 1019
A+A +PG A LGS ++ + E +L S P +R + SS
Sbjct: 653 ALARKNSPGNGSALGPRLGSQPIRASNPDLRR--------TEPILES-PLQRTSSGSSSS 703
Query: 1020 QPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVS------DASIRVGENVSDVAPT 1073
T GG P G A TR R N+ S A ++ E+ P+
Sbjct: 704 SSTPSSQPSSQGGSQP-GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPS 762
Query: 1074 QP 1075
+P
Sbjct: 763 RP 764
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 49.3 bits (116), Expect = 3e-05
Identities = 91/422 (21%), Positives = 157/422 (37%), Gaps = 52/422 (12%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEE 750
Q++ + +A +R+Q ++ + + + + + A RQ+ +++ R L +++RR K L +
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 751 ELERKARQALVDHY-SKLSAEAARREQKALWRIQRHRLESARLRFLLEDE-KHIQEMLKA 808
+ ER+ R+ HY ++ E RR + +R +LE R L+ + K ++ L +
Sbjct: 418 QQEREQRR----HYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVS 473
Query: 809 VSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSA--EQHSPAWDGWNRPGLLTP 866
+ Q Q P + H + E P + + S Q SPA + P
Sbjct: 474 LQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDP 533
Query: 867 QPLKPLAVGAGGRGLQQAEG---ARPFSDSL-------SIGDFLPVGPGAEPSVQTGMVP 916
L P + G+Q A RP + S G L G+
Sbjct: 534 N-LPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
Query: 917 LLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLR-----------------P 959
E T + P + + P+R +++D S+ LR P
Sbjct: 593 FQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISP 652
Query: 960 AVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSS 1019
A+A +PG A LGS ++ + E +L S P +R + SS
Sbjct: 653 ALARKNSPGNGSALGPRLGSQPIRASNPDLRR--------TEPILES-PLQRTSSGSSSS 703
Query: 1020 QPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVS------DASIRVGENVSDVAPT 1073
T GG P G A TR R N+ S A ++ E+ P+
Sbjct: 704 SSTPSSQPSSQGGSQP-GSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPS 762
Query: 1074 QP 1075
+P
Sbjct: 763 RP 764
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 48.9 bits (115), Expect = 4e-05
Identities = 96/402 (23%), Positives = 155/402 (38%), Gaps = 61/402 (15%)
Query: 681 SRVLSALSDRQMSERMALDARKREQFQRLK----EQFVKDQERRQAARQEELD----DDF 732
S++ + + + E + + R+ ++ QR K E+ +++ R+ +E L+ +
Sbjct: 125 SQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE 184
Query: 733 SYARELRDRERRLKSLEEELERK---ARQALVDHYSKLSAE-AARREQKALWRIQRHRLE 788
+E +RER+ + +E LER+ RQ ++ +L E R+E++ L R++R R E
Sbjct: 185 RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE 244
Query: 789 SARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSA 848
R + LE E+ E + +S A P L SV ++ P G + S
Sbjct: 245 RER-QEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEP-------GLQAASQ 296
Query: 849 EQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEP 908
+P+ G G L P P PL G QA A P P GP P
Sbjct: 297 PAETPSQQGIVL-GPLAPPPPPPLPPGPA-----QASVALP----------PPPGPPPPP 340
Query: 909 SVQTGMVPLLEVALQTINLDLPPSAPGEAP--------AAASTQPSRPQEYDFSTVLRPA 960
+ + P N PP P AP A+ ++ +RP T L A
Sbjct: 341 PLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRP-----LTGLAAA 395
Query: 961 VATSPAPGPLQAAECSLGSSGLQLWEDSC----------GKMDACGSASRETLLPSHPPR 1010
+A + + + S S G + +S G + GS E + R
Sbjct: 396 IAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARR 455
Query: 1011 RAALEEGSSQPTERL--FGQVSGGGLPTGDYASEIAPTRPRW 1050
R E+GS+ TE+ G+ S S PTR W
Sbjct: 456 RRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPW 497
Score = 43.9 bits (102), Expect = 0.001
Identities = 51/200 (25%), Positives = 84/200 (42%), Gaps = 25/200 (12%)
Query: 647 MERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQF 706
+E R + +KEL E ++E + R R+ +R ER+ + +RE+
Sbjct: 140 LEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER---ERLEQEQLERERQ 196
Query: 707 QRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSK 766
+R +++ ++ QER + + E + R+ R RL+ LE E + + RQ
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-------- 248
Query: 767 LSAEAARREQKALWRIQRHRLESAR--------LRFLLEDEKHIQEMLKAVSE-AHQPQE 817
E REQ W +R R+ SA L +L D + L+A S+ A P +
Sbjct: 249 ---EQLEREQLE-WERER-RISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ 303
Query: 818 PPDVLLSVHPQVTSPGPEHP 837
VL + P P P P
Sbjct: 304 QGIVLGPLAPPPPPPLPPGP 323
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 48.5 bits (114), Expect = 6e-05
Identities = 42/180 (23%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 656 VSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVK 715
+ +E KE + +Q+L+ +E R + ++ER +++EQ +RL+EQ +
Sbjct: 359 LQQENKERSEALRRQQLL---QEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 716 DQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARRE 775
++E R+ +E+ + R L + ERR K EE + + V+ + E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475
Query: 776 QKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPE 835
Q+ L +Q+ L+ + LL D + H Q PP P +P P+
Sbjct: 476 QRHLEVLQQQLLQEQAM--LLHDHRRPHPQ-------HSQQPPPPQQERSKPSFHAPEPK 526
Score = 38.1 bits (87), Expect = 0.079
Identities = 33/131 (25%), Positives = 69/131 (52%), Gaps = 17/131 (12%)
Query: 646 RMERVARHSSVSKEEKELRMEIA-KQELIAHAREAASRVLSALSDRQMSERMALDARKRE 704
R +++ + + ++E+ R +A +Q+ I +E R L ++Q ER A ++RE
Sbjct: 371 RRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR----LEEQQRREREARRQQERE 426
Query: 705 QFQRLKEQ---------FVKDQERRQAARQEE--LDDDFSY-ARELRDRERRLKSLEEEL 752
Q +R +E+ K++E R+ A +E+ ++ + Y R+L + +R L+ L+++L
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 753 ERKARQALVDH 763
++ L DH
Sbjct: 487 LQEQAMLLHDH 497
Score = 35.0 bits (79), Expect = 0.67
Identities = 48/197 (24%), Positives = 84/197 (42%), Gaps = 50/197 (25%)
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQE--RRQ--AARQEELDDDFSYARELRDRERRLK 746
Q + +A +R+Q L+EQ +++QE +RQ A RQ+ ++ R L +++RR
Sbjct: 360 QQENKERSEALRRQQL--LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR-- 415
Query: 747 SLEEELERKARQALVDHYSKLSAEAARREQ---KALWRIQRHRLESARLRFLLEDEKHI- 802
ER+AR+ + E RREQ + L ++R R E R E+++ +
Sbjct: 416 ------EREARR-------QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 803 --QEMLKAVSEAHQPQ---------EPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQH 851
QE ++ E Q + +LL H + P P+H ++Q
Sbjct: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRR---PHPQH-----------SQQP 508
Query: 852 SPAWDGWNRPGLLTPQP 868
P ++P P+P
Sbjct: 509 PPPQQERSKPSFHAPEP 525
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.5 bits (114), Expect = 6e-05
Identities = 51/206 (24%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 681 SRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELR- 739
S+ ++ +DR+ + R+ + R++ + QR +E+ QERR A +++ + ARE
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREE----QERRLQAERDKRMREEQLAREAEA 642
Query: 740 --DRERRLKSLEEELERKARQALVDHYSKLS-----AEAARREQKALWRIQRHRLESARL 792
+RE + EE+ R+ QA + +L AEA RE+ R++R + +
Sbjct: 643 RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE 702
Query: 793 RFLLEDEKHIQEMLK-----AVSEAHQPQEPPDVLLSVHPQVTSPGP----EHPEGGQGC 843
+ E K ++E++K VSE Q Q+ + + +SP P E G
Sbjct: 703 QERQERRKRLEEIMKRTRKSEVSETKQKQDSKE----ANANGSSPEPVKAVEARSPGLQK 758
Query: 844 DSGSAEQHSPAWDGWNRPGLLTPQPL 869
++ E+ P W+ P P L
Sbjct: 759 EAVQKEEPIPQEPQWSLPSKELPASL 784
Score = 36.2 bits (82), Expect = 0.30
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 13/123 (10%)
Query: 658 KEEKELRMEIAKQELIAH---AREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFV 714
+EE+E R++ + + + AREA +R +ER A R+ EQ R K Q
Sbjct: 616 REEQERRLQAERDKRMREEQLAREAEAR----------AEREAEARRREEQEAREKAQAE 665
Query: 715 KDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARR 774
++++ R ++EE + E + ER ++E ER+ R+ ++ K + ++
Sbjct: 666 QEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVS 725
Query: 775 EQK 777
E K
Sbjct: 726 ETK 728
Score = 35.4 bits (80), Expect = 0.51
Identities = 30/113 (26%), Positives = 59/113 (52%), Gaps = 5/113 (4%)
Query: 646 RMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRV-LSALSDRQMSERMALDARKR- 703
R E+ AR + +++E++ R++ K+E A +RE A R L Q E+ + RKR
Sbjct: 653 REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRL 712
Query: 704 -EQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERK 755
E +R ++ V + +++Q ++ E + + S ++ E R L++E +K
Sbjct: 713 EEIMKRTRKSEVSETKQKQDSK--EANANGSSPEPVKAVEARSPGLQKEAVQK 763
Score = 33.1 bits (74), Expect = 2.5
Identities = 29/92 (31%), Positives = 39/92 (42%), Gaps = 7/92 (7%)
Query: 1248 ASISLGEPVSDVVST--RPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSA 1305
A + G P + V T PR + PP + AL P+ P+TP ++ TS
Sbjct: 7 AELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNA---TSSKQ 63
Query: 1306 LSLGAQSTVLDCGPR--LPVEVGPSLSSPSSG 1335
L L +S GPR P E PS + S G
Sbjct: 64 LPLEPESPSGQVGPRPAPPQEESPSSEAKSRG 95
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 47.8 bits (112), Expect = 1e-04
Identities = 62/243 (25%), Positives = 100/243 (41%), Gaps = 49/243 (20%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDAR---KRE 704
E RH + +++KE +QE + A EA +R+ ER + R +RE
Sbjct: 655 EEERRHQELLQKKKE-----EEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
Query: 705 QFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHY 764
Q +R +E+ + +QERR+ QE L + REL++RE+ L+ +E+L+R
Sbjct: 710 QERREQERQLAEQERRR--EQERLQAE----RELQEREKALRLQKEQLQR---------- 753
Query: 765 SKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEML---KAVSEAHQPQEPPDV 821
+L + + EQ+ R+ +L+ E EK +E KA++ Q P
Sbjct: 754 -ELEEKKKKEEQQ---RLAERQLQE-------EQEKKAKEAAGASKALNVTVDVQSPACT 802
Query: 822 LLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGL 881
+ PQ P+ G D S + P KP+ A G L
Sbjct: 803 SYQMTPQGHRAPPKINPDNYGMDLNSDDSTDD-----------EAHPRKPIPTWARGTPL 851
Query: 882 QQA 884
QA
Sbjct: 852 SQA 854
Score = 44.3 bits (103), Expect = 0.001
Identities = 48/191 (25%), Positives = 84/191 (43%), Gaps = 12/191 (6%)
Query: 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDR 690
E+ K+IE+ A + E+ EEK + AK+ AR L
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLA--EEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQER-RQAARQEELDDDFSYAR---ELRDRERRLK 746
Q E + R +E Q+ KE+ +QER R+AA + L + R E R++ERR +
Sbjct: 652 QQEEE---ERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
Query: 747 SLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEML 806
E+ R+ + L + + E + E++ R + RL+ +L+ LE++K +E
Sbjct: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
Query: 807 KAVSEAHQPQE 817
+ Q ++
Sbjct: 766 RLAERQLQEEQ 776
Score = 35.4 bits (80), Expect = 0.51
Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 33/167 (19%)
Query: 654 SSVSKEEKEL----RMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRL 709
S V KE + L R E A+Q E R L + ++ ER+ + RE+ +++
Sbjct: 533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARERVEQM 591
Query: 710 KEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSA 769
KE+ ++++++ F+ E ++ + + EE+ ++KA K+
Sbjct: 592 KEE-----------KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA------KKMEE 634
Query: 770 EAARREQKALWRIQRHRLESARLRFLL--EDEKHIQEMLKAVSEAHQ 814
ARR+Q+ E+ RLR+L E+E+ QE+L+ E Q
Sbjct: 635 VEARRKQEE---------EARRLRWLQQEEEERRHQELLQKKKEEEQ 672
Score = 34.3 bits (77), Expect = 1.1
Identities = 36/142 (25%), Positives = 61/142 (42%), Gaps = 34/142 (23%)
Query: 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELR-MEIAKQELIAHAREAASRVLSALS 688
L++ KE E++ +R+A + E+E R E +QE R R L+
Sbjct: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 723
Query: 689 DRQMSERMALDAR----------KREQFQR-LKEQFVKDQERRQAARQEELDDDFSYARE 737
R+ ER+ + ++EQ QR L+E+ K++++R A RQ
Sbjct: 724 RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ------------ 771
Query: 738 LRDRERRLKSLEEELERKARQA 759
L+EE E+KA++A
Sbjct: 772 ----------LQEEQEKKAKEA 783
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 47.8 bits (112), Expect = 1e-04
Identities = 62/243 (25%), Positives = 100/243 (41%), Gaps = 49/243 (20%)
Query: 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDAR---KRE 704
E RH + +++KE +QE + A EA +R+ ER + R +RE
Sbjct: 651 EEERRHQELLQKKKE-----EEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
Query: 705 QFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHY 764
Q +R +E+ + +QERR+ QE L + REL++RE+ L+ +E+L+R
Sbjct: 706 QERREQERQLAEQERRR--EQERLQAE----RELQEREKALRLQKEQLQR---------- 749
Query: 765 SKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEML---KAVSEAHQPQEPPDV 821
+L + + EQ+ R+ +L+ E EK +E KA++ Q P
Sbjct: 750 -ELEEKKKKEEQQ---RLAERQLQE-------EQEKKAKEAAGASKALNVTVDVQSPACT 798
Query: 822 LLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGL 881
+ PQ P+ G D S + P KP+ A G L
Sbjct: 799 SYQMTPQGHRAPPKINPDNYGMDLNSDDSTDD-----------EAHPRKPIPTWARGTPL 847
Query: 882 QQA 884
QA
Sbjct: 848 SQA 850
Score = 44.3 bits (103), Expect = 0.001
Identities = 48/191 (25%), Positives = 84/191 (43%), Gaps = 12/191 (6%)
Query: 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDR 690
E+ K+IE+ A + E+ EEK + AK+ AR L
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEERLA--EEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 691 QMSERMALDARKREQFQRLKEQFVKDQER-RQAARQEELDDDFSYAR---ELRDRERRLK 746
Q E + R +E Q+ KE+ +QER R+AA + L + R E R++ERR +
Sbjct: 648 QQEEE---ERRHQELLQKKKEE---EQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
Query: 747 SLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEML 806
E+ R+ + L + + E + E++ R + RL+ +L+ LE++K +E
Sbjct: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
Query: 807 KAVSEAHQPQE 817
+ Q ++
Sbjct: 762 RLAERQLQEEQ 772
Score = 42.4 bits (98), Expect = 0.004
Identities = 38/142 (26%), Positives = 71/142 (50%), Gaps = 18/142 (12%)
Query: 689 DRQMSERMALD-ARKREQFQRLKEQFVKDQERRQ----AARQEELDDDFSYARELRDR-- 741
D + ER L+ R++E+ ++L+ Q V++ +RR+ ++EE ARE ++
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
Query: 742 -------ERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRF 794
E++ ++E+ E+ + L + +K A A + E+ R Q E+ RLR+
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE--EARRLRW 646
Query: 795 LL--EDEKHIQEMLKAVSEAHQ 814
L E+E+ QE+L+ E Q
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQ 668
Score = 34.3 bits (77), Expect = 1.1
Identities = 36/142 (25%), Positives = 61/142 (42%), Gaps = 34/142 (23%)
Query: 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELR-MEIAKQELIAHAREAASRVLSALS 688
L++ KE E++ +R+A + E+E R E +QE R R L+
Sbjct: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 719
Query: 689 DRQMSERMALDAR----------KREQFQR-LKEQFVKDQERRQAARQEELDDDFSYARE 737
R+ ER+ + ++EQ QR L+E+ K++++R A RQ
Sbjct: 720 RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ------------ 767
Query: 738 LRDRERRLKSLEEELERKARQA 759
L+EE E+KA++A
Sbjct: 768 ----------LQEEQEKKAKEA 779
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,354,023
Number of Sequences: 37866
Number of extensions: 4007843
Number of successful extensions: 20143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 674
Number of HSP's that attempted gapping in prelim test: 16509
Number of HSP's gapped (non-prelim): 2955
length of query: 1819
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1702
effective length of database: 13,817,196
effective search space: 23516867592
effective search space used: 23516867592
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.