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Search of human proteins with 56550043
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56550043 sarcolemma associated protein [Homo sapiens]
(811 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56550043 sarcolemma associated protein [Homo sapiens] 1577 0.0
gi|13435127 TRAF3-interacting JNK-activating modulator [Homo sap... 153 5e-37
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 134 4e-31
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 116 1e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 113 8e-25
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 113 8e-25
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 113 8e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 113 8e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 112 1e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 112 2e-24
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 112 2e-24
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 111 3e-24
gi|31982906 cingulin-like 1 [Homo sapiens] 111 3e-24
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 110 5e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 110 5e-24
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 110 7e-24
gi|16262452 cingulin [Homo sapiens] 108 3e-23
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 107 3e-23
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 106 1e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 106 1e-22
gi|50083279 centrosome protein 4 [Homo sapiens] 106 1e-22
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 106 1e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 105 2e-22
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 105 2e-22
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 104 3e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 104 3e-22
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 104 3e-22
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 104 3e-22
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 103 8e-22
gi|55770834 centromere protein F [Homo sapiens] 103 8e-22
>gi|56550043 sarcolemma associated protein [Homo sapiens]
Length = 811
Score = 1577 bits (4084), Expect = 0.0
Identities = 811/811 (100%), Positives = 811/811 (100%)
Query: 1 MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWF 60
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWF
Sbjct: 1 MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWF 60
Query: 61 DHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGC 120
DHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGC
Sbjct: 61 DHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGC 120
Query: 121 IVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQ 180
IVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQ
Sbjct: 121 IVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQ 180
Query: 181 MLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKEL 240
MLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKEL
Sbjct: 181 MLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKEL 240
Query: 241 IALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEEL 300
IALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEEL
Sbjct: 241 IALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEEL 300
Query: 301 RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKI 360
RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKI
Sbjct: 301 RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKI 360
Query: 361 EALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKE 420
EALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKE
Sbjct: 361 EALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKE 420
Query: 421 NQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQ 480
NQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQ
Sbjct: 421 NQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQ 480
Query: 481 EIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHI 540
EIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHI
Sbjct: 481 EIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHI 540
Query: 541 DTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELE 600
DTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELE
Sbjct: 541 DTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELE 600
Query: 601 RWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLK 660
RWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLK
Sbjct: 601 RWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLK 660
Query: 661 RENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK 720
RENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK
Sbjct: 661 RENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK 720
Query: 721 TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGN 780
TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGN
Sbjct: 721 TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGN 780
Query: 781 NKPWPWMPMLAALVAVTAIVLYVPGLARASP 811
NKPWPWMPMLAALVAVTAIVLYVPGLARASP
Sbjct: 781 NKPWPWMPMLAALVAVTAIVLYVPGLARASP 811
>gi|13435127 TRAF3-interacting JNK-activating modulator [Homo
sapiens]
Length = 531
Score = 153 bits (387), Expect = 5e-37
Identities = 101/343 (29%), Positives = 177/343 (51%), Gaps = 18/343 (5%)
Query: 159 SMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLE 218
++ +E+ QLS YL+EAL RE +L+QK+ LQ LL+ +ASD+SW+ ++ED+L +L
Sbjct: 168 AVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLR 227
Query: 219 VMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
+ NQL C++ + ++K L+ +++ K++YE AKESL++VL+EK+ ++L +RS
Sbjct: 228 SLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRS 287
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
L+ E +C + E +E+ R L ++ +++ L KL+ A+ + ++ Q
Sbjct: 288 LALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQ----- 342
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIEC 398
+ +E + Q+LQAKIE LQ D D + LQ+ L T + + +
Sbjct: 343 ------ALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQL 396
Query: 399 QKKLIVEGHLTKAVEETKLSKENQTRA--KESDFSDTLSP---SKEKSSDDTTDAQMDEQ 453
Q L+ L +E L+K++Q F + + P KEK D Q
Sbjct: 397 Q-GLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTL 455
Query: 454 DLNEPLAKVSLLKDDLQGAQSE-IEAKQEIQHLRKELIEAQEL 495
L + L +L E + +++QH R+EL ++Q+L
Sbjct: 456 QLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQL 498
Score = 48.1 bits (113), Expect = 3e-05
Identities = 84/366 (22%), Positives = 159/366 (43%), Gaps = 51/366 (13%)
Query: 465 LKDDLQGA-QSEIEAKQE---IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQ 520
L D L+ A Q E+ KQ+ +Q L LI+A + + + +L+ L ++ NQ
Sbjct: 177 LSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKL----RSLENQ 232
Query: 521 VEESTKQIQVLQAQLQRLHI-DTENLREEKDSE-ITSTRDELLSARDEILLLHQAAAKVA 578
+ T++ + L + D +N E+K E + +E ++A ++ ++ A +A
Sbjct: 233 LYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLA-LA 291
Query: 579 SERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCE--DQQREEAT 636
++ + S E LK E WR +++ +E+ S + Q + Q + D Q +A
Sbjct: 292 EQKCEEWRSQYEALK------EDWRTLGTQH-RELESQLHVLQSKLQGADSRDLQMNQAL 344
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQM 696
R L E L+ + L+ + L S + Q + +L S+ + L L + + LQ
Sbjct: 345 RF------LENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQG 398
Query: 697 SRKELENQVGSLKEQHL----RDSA----DLKTLLSKAENQAKDVQKEYE-KTQTVLSEL 747
L+NQ L+EQ +D A K+ ++ E + +K+++ + Q L
Sbjct: 399 L---LQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTL 455
Query: 748 KLKFEMTE-----QEKQSITDELKQCKNNLKLLREKGNNKP--------WPWMPMLAALV 794
+L+ + E E +++DE C L+ RE+ N W+P+L ++
Sbjct: 456 QLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVI 515
Query: 795 AVTAIV 800
A V
Sbjct: 516 AAALAV 521
Score = 46.2 bits (108), Expect = 1e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 52/263 (19%)
Query: 461 KVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK-------QKCFELQA---LL 510
K LL+ + Q E +AK+ +Q + +E + A++ ++++ QKC E ++ L
Sbjct: 246 KKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEAL 305
Query: 511 EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLL 570
+E+ + Q E Q+ VLQ++LQ D+ +L+ + + L A+ E L
Sbjct: 306 KEDWRTLGTQHRELESQLHVLQSKLQGA--DSRDLQMNQALRFLENEHQQLQAKIECL-- 361
Query: 571 HQAAAKVASERDT---DIASLQEELKKVRAE--------------LERWRKAASEYEKEI 613
+RD D LQ++LK+ AE L+ E EK +
Sbjct: 362 -------QGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLL 414
Query: 614 TSLQNSFQLRCQQC-------EDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLL 666
T + + + E +E+ L+ +L+K + A E EC L E L
Sbjct: 415 TKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNL 474
Query: 667 SSE-------LQRQEKELHNSQK 682
S E LQ +EL+ SQ+
Sbjct: 475 SDEYLSCLRKLQHCREELNQSQQ 497
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 134 bits (336), Expect = 4e-31
Identities = 106/351 (30%), Positives = 183/351 (52%), Gaps = 23/351 (6%)
Query: 434 LSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQG---AQSEIEA-KQEIQHLRKEL 489
L +E+ ++ + + +E+ + + + SL + +G ++E+E + ++ L EL
Sbjct: 13 LYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAEL 72
Query: 490 IEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEK 549
E +ELA + ELQ LLE+ER A Q E TKQIQ LQ +L+ L + L EK
Sbjct: 73 EETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEK 132
Query: 550 DSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEY 609
+SE+ EL A+ EI L QAA A+E ++DIASLQE+L +++ ELE + +Y
Sbjct: 133 ESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDY 192
Query: 610 EKEITSLQNSFQLRCQQCEDQ-QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSS 668
E EI SL+ +++ + + + LQ EL++LR+ ++ L E +L+ N L+
Sbjct: 193 EMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTG 252
Query: 669 ELQRQEKELHNS------QKQSLELTS-DLSILQMSRKELENQVGSLKEQHLRDSADLKT 721
+L E E Q Q+L +TS + +M E + ++ L++Q LRD
Sbjct: 253 QLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQ-LRD------ 305
Query: 722 LLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
AE Q ++ + ++ L EL+ +++E+E++ + ELK +N +
Sbjct: 306 ----AEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEV 352
Score = 75.9 bits (185), Expect = 1e-13
Identities = 147/667 (22%), Positives = 271/667 (40%), Gaps = 120/667 (17%)
Query: 180 QMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTED----- 234
Q L+ +L +L+ +++ + ++ + I+++ L++ E+ + QA + TE
Sbjct: 112 QQLQGELRSLREEISLLEHEKESELKE-IEQELHLAQAEIQSLR-QAAEDSATEHESDIA 169
Query: 235 SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-----SNTEDECTHL 289
SL+++L +Q + + E + + + E+ K SE SL S ++E L
Sbjct: 170 SLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQEL 229
Query: 290 KEMNERTQEELRELANKYNGAVNEIKDLSDK----------------------------- 320
+E EE R L + ++ DL +
Sbjct: 230 RERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDF 289
Query: 321 -------------LKVAEGKQEEIQQKGQ---AEKKELQHKIDEMEEKEQELQAKIEALQ 364
L+ AE + ++ K Q E +ELQH EE+++ LQ +++ Q
Sbjct: 290 LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQ 349
Query: 365 AD-NDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQT 423
+ F E L S+ CT QKK + + E K+ + QT
Sbjct: 350 NEVLRFQTSHSVTQNEELKSRL---CTL-------QKK--YDTSQDEQNELLKMQLQLQT 397
Query: 424 RAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQ-E 481
++ TL ++ + ++ Q N K LL+ Q Q E++ + E
Sbjct: 398 ELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQ-QQLQEELQCHEAE 456
Query: 482 IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHID 541
+QHLR + +E S +K E A L+E ++ Y+ +E +Q + Q L +
Sbjct: 457 LQHLRDTVASFKE----SNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLC 512
Query: 542 TENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELER 601
L+E K S + + K A++ DT ++ L E +K +A
Sbjct: 513 QLELKELKASH----------------PIPEDKGKCANKCDTLLSRLTELQEKYKAS--- 553
Query: 602 WRKAASEYEKEITSLQNSFQLRCQQCEDQQR--EEATRLQGELEKLR----KEWNALETE 655
+KE+ LQ +C+ EDQ+R EE +LQ EL +L K L+++
Sbjct: 554 --------QKEMGQLQME---QCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQ 602
Query: 656 CHSLKRENV----LLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQ 711
K E++ LL +Q ++K+L Q Q L L I + R+ E+ + E
Sbjct: 603 ELLTKLEDLCELQLLYQGMQEEQKKL--IQNQDCVLKEQLEIHEELRRFKESHFQEVLE- 659
Query: 712 HLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNN 771
+ DS K+ Q+K + ++ + Q + + K E+ +QE+ + +E K+ + +
Sbjct: 660 NPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQAD 719
Query: 772 LKLLREK 778
L+L E+
Sbjct: 720 LQLCLEE 726
Score = 74.3 bits (181), Expect = 4e-13
Identities = 135/655 (20%), Positives = 267/655 (40%), Gaps = 101/655 (15%)
Query: 178 REQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLR 237
+ + L+ +L TLQ+ +Q+ + + + L +L+VM + L +NQ+E L
Sbjct: 363 QNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLV---ENQSEKELL 419
Query: 238 KELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNER-- 295
L L +H T KE L L+ + ++ +L E L + D KE NE+
Sbjct: 420 CRLQKLHL-QHQNVTCEKEKL---LERQQQLQEELQCHEAELQHLRDTVASFKESNEKDT 475
Query: 296 -TQEELRELANKYNGAVNEIK-------DLSDKLKVAEGKQEEI-------QQKGQAEKK 340
T +L+E+ Y + +E++ L L + + + +E+ + KG+ K
Sbjct: 476 ETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANK 535
Query: 341 ---------ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL------LSKS 385
ELQ K +++ +LQ + L D E LQE L L KS
Sbjct: 536 CDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKS 595
Query: 386 G---------------GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDF 430
G + ++Q ++ ++K +++ E+ ++ +E + R KES F
Sbjct: 596 GLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELR-RFKESHF 654
Query: 431 SDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELI 490
+ L ++ DD+ A+ + + N+ + LL + +Q Q +A Q ++EL+
Sbjct: 655 QEVL-----ENPDDSKLAKSSKCNRNK---QSKLLMEQMQALQVMYDAGQ----AKQELL 702
Query: 491 EAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKD 550
+ + Q L EERK + ++ +++Q+LQ Q + + E+ +
Sbjct: 703 QQE-------------QGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYG 749
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYE 610
S + S + D + +++ K S Q K + A+ Y
Sbjct: 750 SMVPS-NENCRKTYDTTVDDNESYYK-------SYTSTQTSSKSFLKSYDSSTSASEAYG 801
Query: 611 KEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL 670
K + NS + ++ T + + E A + + V + +L
Sbjct: 802 KSYCTTSNS-SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKL 860
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730
Q + SQ++ +L + L +K+L+ ++ + + R+ + L K
Sbjct: 861 QAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACE----REFKECMECLEKPMAPQ 916
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQE-------KQSITDELKQCKNNLKLLREK 778
D + E ++ QT L EL+L+++ + E ++ + +L+ C+ L+ LREK
Sbjct: 917 ND-KNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREK 970
Score = 65.5 bits (158), Expect = 2e-10
Identities = 128/610 (20%), Positives = 254/610 (41%), Gaps = 105/610 (17%)
Query: 240 LIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEV-------ERSLSNTEDECTHLKEM 292
L AL E++ E +E ++E+ E V+K V R LS TE E L+
Sbjct: 10 LPALYEEEEEEEEEEEE-----VEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQ 64
Query: 293 NERTQ---EELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEM 349
+ EE RELA ++ E++ L + ++A +Q E+ K
Sbjct: 65 VLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTK--------------- 109
Query: 350 EEKEQELQAKIEALQAD-NDFTNERLTALQE-----HL-------LSKSGGDCTFIHQ-- 394
+ Q+LQ ++ +L+ + + +E+ + L+E HL L ++ D H+
Sbjct: 110 --QIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESD 167
Query: 395 FIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFS-DTLSPSKEKSSDDTTDAQMDEQ 453
Q+ L + + +E + E + + ++ + PS D + Q + Q
Sbjct: 168 IASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQ 227
Query: 454 D-------LNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFEL 506
+ LNE + L G +++E+ + Q + +++Q L+ TS +
Sbjct: 228 ELRERYHFLNEEYRALQESNSSLTGQLADLES-ERTQRATERWLQSQTLSMTSAESQTSE 286
Query: 507 QALLE--EERKAYRNQVEESTKQIQVLQAQLQRLHIDTENL---REEKDSEITSTRDELL 561
LE E + R Q+ ++ +Q+ ++ + Q L + E L R+ + E + EL
Sbjct: 287 MDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELK 346
Query: 562 SARDEILLLHQAAAKVASER-DTDIASLQE----------ELKKVRAELERWRKAASEYE 610
A++E+L + + +E + + +LQ+ EL K++ +L+ + +
Sbjct: 347 CAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMK 406
Query: 611 KEITSLQNSFQLRCQ-----------QCE--------DQQREEATRLQGELEKLR----- 646
+ Q+ +L C+ CE Q +EE + EL+ LR
Sbjct: 407 STLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVAS 466
Query: 647 -KEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQV 705
KE N +TE H+ +E + Q + EL + +L DL + Q+ KEL+
Sbjct: 467 FKESNEKDTETHAQLQE---MKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKAS- 522
Query: 706 GSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDEL 765
+ E + + TLLS+ ++Q++Y+ +Q + +L+++ ++++ + +E
Sbjct: 523 HPIPEDKGKCANKCDTLLSR----LTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQ 578
Query: 766 KQCKNNLKLL 775
Q + L L
Sbjct: 579 GQLQEELHRL 588
Score = 62.4 bits (150), Expect = 2e-09
Identities = 139/682 (20%), Positives = 272/682 (39%), Gaps = 62/682 (9%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDR---------L 213
QE+ QL Q ++ L R++ + +L Q LL E + I ED+ L
Sbjct: 482 QEMKQLYQASKDELERQKHMYDQLE--QDLLLCQLELKELKASHPIPEDKGKCANKCDTL 539
Query: 214 LSRLEVMGNQLQACSKNQTEDSLRK-ELIALQEDKHNYETTAKESLRRVLQEKIEVVRKL 272
LSRL + + +A K + + + EL+ Q + +E L R L + L
Sbjct: 540 LSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHR-LTLPLPKSGLL 598
Query: 273 SEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK---------V 323
+ + L+ ED C L+ + + QEE ++L + + E ++ ++L+ V
Sbjct: 599 LKSQELLTKLEDLC-ELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEV 657
Query: 324 AEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL-- 381
E + K + Q K+ + E+ Q LQ +A QA + + L E
Sbjct: 658 LENPDDSKLAKSSKCNRNKQSKL--LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR 715
Query: 382 LSKSGGDCTFIHQFIECQK---KLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSK 438
L C Q ++ Q K+ +E + K+ S EN + ++ D S K
Sbjct: 716 LQADLQLCLEEMQLLQVQSPSIKMSLESY-GKSYGSMVPSNENCRKTYDTTVDDNESYYK 774
Query: 439 EKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELART 498
+S T+ + + A + K + S I K+ + ++
Sbjct: 775 SYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSS----SDTCQKS 830
Query: 499 SKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRD 558
C + + E+ + + V + ++Q +QA Q + L+E+ + + +D
Sbjct: 831 FVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKD 890
Query: 559 ---ELLSARDEILLLHQAAAK-VASERD-TDIASLQEELKKVRAELERWRKAASEYEKEI 613
EL + E + K +A + D +I LQ +L+ EL+ +A+ + + +
Sbjct: 891 LKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR----ELQLQYQASMDEQGRL 946
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNA---LETECHSLKRENVLL---- 666
+Q + + Q C+++ R+ + +++ R + NA + + +K + V
Sbjct: 947 LVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGK-NANKNMNKNANGVKMKKVTKPCSD 1005
Query: 667 --SSELQ-RQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLL 723
S+L+ R+ E+ K S L+ + ++E+E + +KE+ D
Sbjct: 1006 TSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAE 1065
Query: 724 SKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKL-LREKGNNK 782
+AK + + E + E + K E +E+E+ L+ + N L L E +
Sbjct: 1066 PADPEEAKSTEDQEENEED--KEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSS 1123
Query: 783 PWPWMPM----LAALVAVTAIV 800
P P P+ L LV ++A++
Sbjct: 1124 PTPNPPIFSLPLVGLVVISALL 1145
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 116 bits (290), Expect = 1e-25
Identities = 140/571 (24%), Positives = 255/571 (44%), Gaps = 92/571 (16%)
Query: 243 LQEDKHNYETTAKES-LRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE--- 298
LQ + E AKE L +V ++++ +L+E+E S E L+E + E
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 299 ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQA 358
E EL + E++++ L+ ++EE Q QAEKK++Q I E+EE+ +E ++
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 359 KIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLS 418
+ LQ + T +L L+E + +C + +KKL+ E +++
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK-----LAKEKKLL----------EDRIA 1002
Query: 419 KENQTRAKESDFSDTLSPSKEKSSDDTTD-------AQMDEQDLNEPLAKVSLLKDDLQG 471
+ +E + S +L+ K K TD + Q+L + K+ DL
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 472 AQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLE--EERKAYRNQVEESTKQIQ 529
+E++A +I L+ +L + +E ELQA L EE A +N + K+I+
Sbjct: 1063 QIAELQA--QIAELKMQLAKKEE----------ELQAALARVEEEAAQKNM---ALKKIR 1107
Query: 530 VLQAQLQRLHIDTENLREEKDSEITSTRD---ELLSARDEI---LLLHQAAAKVASERDT 583
L++Q+ L D E+ R ++ RD EL + + E+ L A ++ S+R+
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
Query: 584 DI----ASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQ 639
++ +L+EE K A+++ R+ S+ +E+ +Q E+ R++
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA---------------EQLEQTKRVK 1212
Query: 640 GELEKLRKEWNALETECHSLKRE-NVLL-------------SSELQRQEKELHNSQKQSL 685
LEK ++ LE E L E VLL ++LQ + + + ++
Sbjct: 1213 ANLEKAKQ---TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269
Query: 686 ELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLS 745
EL ++ LQ+ EL+N G L + + S+ L S E+Q +D Q+ ++
Sbjct: 1270 ELADKVTKLQV---ELDNVTGLLSQSDSK-SSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 746 ELKLKFEMTEQEKQSITDEL---KQCKNNLK 773
L K + E EK S ++L ++ K+NL+
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Score = 104 bits (260), Expect = 3e-22
Identities = 130/667 (19%), Positives = 289/667 (43%), Gaps = 92/667 (13%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEAS--DTSWQALIDED---RLLSRL 217
+++ Q Q L+E L E+ QKL +L +T EA + +I ED +L
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKL----QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994
Query: 218 EVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETT-AKESLRRVLQEKIEVVRKLSEVE 276
+++ +++ + N TE+ + + +A ++KH T +E LRR +++ E+ + ++E
Sbjct: 995 KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054
Query: 277 RSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQ 336
++ D+ L+ + +L + + A+ +++ + + +A K E++ +
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114
Query: 337 AEKKELQHKI---DEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIH 393
+++L+ + ++ E+++++L ++EAL+ + + T + TA Q+ L SK + +
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS-TAAQQELRSKREQEVNILK 1173
Query: 394 QFIE-------------CQKKLIVEGHLTKAVEETKLSKENQTRAKES------DFSDTL 434
+ +E QK L + +E+TK K N +AK++ + ++ +
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 435 SPSKEKSSDDT-----TDAQMDE------------QDLNEPLAKVSLLKDDLQGAQSEIE 477
+ D +AQ+ E +L + + K+ + D++ G S+ +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 478 AK-----QEIQHLRKELIEAQELARTSKQKCFELQALL---EEERKAYRNQVEESTKQIQ 529
+K ++ L +L + QEL + ++ L L E+E+ ++R Q+EE +
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 530 VLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQ 589
L+ Q+ LH +++++ + + + A +V + D+ L
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCL---------------ETAEEVKRKLQKDLEGLS 1398
Query: 590 EELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEW 649
+ ++ A ++ K + ++E+ L D QR+ A L EK +K++
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDL--------DHQRQSACNL----EKKQKKF 1446
Query: 650 NALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLK 709
+ L E ++ + + E R E E + ++L L L + ELE L
Sbjct: 1447 DQLLAEEKTISAK---YAEERDRAEAEAREKETKALSLARALEEAMEQKAELER----LN 1499
Query: 710 EQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCK 769
+Q + DL + +++K + + E+K + E E E Q+ D + +
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 770 NNLKLLR 776
NL+ ++
Sbjct: 1560 VNLQAMK 1566
Score = 87.0 bits (214), Expect = 6e-17
Identities = 151/723 (20%), Positives = 298/723 (41%), Gaps = 125/723 (17%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
+SQ + +L++ L++ + LE+ TL+ Q D + ++E
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 221 GNQLQA---------------CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEK 265
+LQ +K Q E L++ + K + T +L LQ+
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 266 IEVVRKLSEVERSLSN----TEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKL 321
E++++ + + SLS EDE +E E +E L + ++ D+ K+
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373
Query: 322 KVAEG---KQEEIQQKGQAEKKELQHK-------IDEMEEKEQELQAKIEALQADNDFTN 371
+ + G EE+++K Q + + L + D++E+ + LQ +++ L D D
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 372 ERLTALQ------EHLLSKSGGDCTFIHQFIECQKKLIVEGH--------LTKAVEET-- 415
+ L+ + LL++ + T ++ E + + E L +A+EE
Sbjct: 1434 QSACNLEKKQKKFDQLLAE---EKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 416 -KLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMD----EQDLNEPLAKVSLLKDDLQ 470
K E + ++ D +S SK+ + + EQ + E ++ L+D+LQ
Sbjct: 1491 QKAELERLNKQFRTEMEDLMS-SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 471 GAQS-----EIEAKQEIQHLRKELIEAQELARTSKQKCF----ELQALLEEERKAYRNQV 521
+ E+ + ++L E + K++ E++A LE+ERK R+
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMA 1608
Query: 522 EESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTR-------------DELLSARDEIL 568
+ K++++ L+ HID+ N + +D I R D+ ++R+EIL
Sbjct: 1609 VAARKKLEMDLKDLEA-HIDSAN--KNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 569 LLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITS-LQNS-------- 619
+ K + ++ LQEEL A ER ++ A + E+ + NS
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEEL----AAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 620 -----FQLRCQQCEDQQREEATR---LQGELEKLRKEWNALETEC-----HSLKRENVLL 666
+ R Q E++ EE + L+K + + + T+ H+ K EN
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA-- 1779
Query: 667 SSELQRQEKELHNSQKQSLELT------SDLSILQMSRKELENQVGS-LKEQHL------ 713
+L+RQ KEL + Q +E T + ++ L+ +LE Q+ + KE+
Sbjct: 1780 RQQLERQNKEL-KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR 1838
Query: 714 RDSADLKTLLSKAENQAKDVQK---EYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKN 770
R LK +L + +++ ++ ++ + +K T L +LK + E E+E Q ++ +
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Query: 771 NLK 773
L+
Sbjct: 1899 ELE 1901
Score = 81.3 bits (199), Expect = 3e-15
Identities = 126/676 (18%), Positives = 283/676 (41%), Gaps = 64/676 (9%)
Query: 140 DVIHAPLPSPVDKVAANTP--SMYSQELFQLSQYLQEAL--HREQMLEQKLATLQRLLAI 195
+ + L +D AA S QE+ L + L+E H Q+ E + Q + +
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 196 TQEASDTSWQALIDEDRLLSRLE----VMGNQLQACSKNQTEDSLRKELIALQEDKHNYE 251
++ T + + ++ LE + N+++ + + + +++ + Q + +
Sbjct: 1202 AEQLEQTK-RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260
Query: 252 TTAKESLRRVLQEKIEVVR-KLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGA 310
E +R L +K+ ++ +L V LS ++ + + L + + +L++
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 311 VNEIKDLSDKLKVAEGKQEEIQQKGQAE---KKELQHKIDEMEEKEQELQAKIEALQADN 367
+ LS KLK E ++ +++ + E K L+ +I + + +++ K+E
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 368 DFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRA-- 425
+ E LQ+ L S + + + +K + L + +++ + ++Q ++
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK---TKTRLQQELDDLLVDLDHQRQSAC 1437
Query: 426 ----KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQE 481
K+ F L+ K S+ + E + E K L L+ A +E K E
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA---MEQKAE 1494
Query: 482 IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQ----- 536
++ L K+ E +SK + LE+ ++A QVEE Q++ L+ +LQ
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 537 --RLHIDTENLREEKDSEITSTRDELLSARDEILL--LHQAAAKVASERDTDIAS----- 587
RL ++ + ++ + + ++ RDE + + L+ + + A++ ER +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQG-RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 588 -LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ--REEATRLQGELEK 644
L+ +LK + A ++ K E K++ LQ + ++ +D + REE E EK
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673
Query: 645 LRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDL-------SILQMS 697
K S++ E + L EL E+ +Q++ EL ++ ++
Sbjct: 1674 KLK----------SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 698 RKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQE 757
++ LE ++ L+E+ + + + + ++ K + ++ T L+ + + E
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELI----NDRLKKANLQIDQINTDLNLERSHAQKNENA 1779
Query: 758 KQSITDELKQCKNNLK 773
+Q + + K+ K L+
Sbjct: 1780 RQQLERQNKELKVKLQ 1795
Score = 68.6 bits (166), Expect = 2e-11
Identities = 113/530 (21%), Positives = 217/530 (40%), Gaps = 69/530 (13%)
Query: 151 DKVAA-----NTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLA--------ITQ 197
+KVAA T + QEL L L LE+K +LLA +
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 198 EASDTSWQALIDEDRLLSRLEVMGNQL-QACSKNQTEDSLRKELIALQEDKHNYETTAKE 256
E +A E + LS + + Q + R E+ L K + + E
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 257 --SLRRVLQEKIEVVR-KLSEVERSLSNTEDEC----THLKEMNERTQEELR----ELAN 305
+R L++++E ++ +L E+E L TED +L+ M + + +L+ +
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 306 KYNGAVNEIKDLSDKLKVAEGKQEEI----QQKGQAEKKELQHKIDEMEEKEQELQAKIE 361
K V +++++ +L+ E KQ + ++K + + K+L+ ID + E ++
Sbjct: 1583 KKKQLVRQVREMEAELE-DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 362 ALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKL-IVEGHLTKAVEETKLSK- 419
LQA + + L + S+ + Q E +KKL +E + + EE ++
Sbjct: 1642 KLQAQ---MKDCMRELDDTRASRE----EILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Query: 420 -ENQTRAKESDFSDTLSPS--------KEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQ 470
+ Q + + + +D ++ S +EK + AQ++E+ L E L+ D L+
Sbjct: 1695 AKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE-LEEEQGNTELINDRLK 1753
Query: 471 GAQSEIE------------------AKQEIQHLRKEL-IEAQELARTSKQKCFELQALLE 511
A +I+ A+Q+++ KEL ++ QE+ T K K LE
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 512 EERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLH 571
+ Q++ TK+ Q Q++R +++ + D E + A L
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLK 1873
Query: 572 QAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
Q ++ E + + +K++ ELE + A +E++SL+N +
Sbjct: 1874 QLKRQL-EEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 46.2 bits (108), Expect = 1e-04
Identities = 75/374 (20%), Positives = 163/374 (43%), Gaps = 43/374 (11%)
Query: 179 EQMLEQKLATLQRLLAITQEASDTSWQ---ALIDEDRLLSRLEVMGNQLQACSKNQTE-- 233
EQ E+K ++++ + E D Q A+ +L L+ + + + +KN+ E
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 234 DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMN 293
LRK +++ + T + S +L + E +KL +E + ++E +
Sbjct: 1638 KQLRKLQAQMKDCMRELDDT-RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 294 ERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKE 353
+ Q+E ELA+ EI + S K +A EK+ L+ +I ++EE+
Sbjct: 1697 RQAQQERDELAD-------EIANSSGKGALA-----------LEEKRRLEARIAQLEEEL 1738
Query: 354 QELQAKIEALQADNDFTNERLTALQEHL-LSKSGGDCTF-IHQFIECQKKLIVEGHLTKA 411
+E Q E + N ++ + L L +S Q +E Q K L
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK-----ELKVK 1793
Query: 412 VEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQM-------DEQDLNEPLAKVSL 464
++E + + +++ +A + ++ +E+ ++T + Q E+ L + L +V
Sbjct: 1794 LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD 1853
Query: 465 LKDDLQGAQSEIE-AKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEE 523
+ + + + + + A ++ L+++L EA+E A+ + +LQ LE+ + +
Sbjct: 1854 ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATET----ADA 1909
Query: 524 STKQIQVLQAQLQR 537
+++ L+ +L+R
Sbjct: 1910 MNREVSSLKNKLRR 1923
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/252 (23%), Positives = 112/252 (44%), Gaps = 26/252 (10%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
E+ QL + L A ++ +Q+ L +A +S AL ++ RL +R+ + +
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIA---NSSGKGALALEEKRRLEARIAQLEEE 1737
Query: 224 LQACSKNQTEDSLRKELIALQEDKHNYETTAK-------ESLRRVLQEKIEVVR-KLSEV 275
L+ N + R + LQ D+ N + + E+ R+ L+ + + ++ KL E+
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM 1797
Query: 276 ERSL-SNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----VAEGKQE 329
E ++ S + T L+ + +E+L + A +++ KLK V + ++
Sbjct: 1798 EGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857
Query: 330 EIQQKGQAEK-----KELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSK 384
Q K QA+K K+L+ +++E EE+ Q A LQ + + E A+ + S
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSL 1917
Query: 385 SG----GDCTFI 392
GD F+
Sbjct: 1918 KNKLRRGDLPFV 1929
Score = 40.0 bits (92), Expect = 0.009
Identities = 43/208 (20%), Positives = 87/208 (41%), Gaps = 18/208 (8%)
Query: 156 NTPSMYSQELFQLSQYLQEALHREQM-LEQKLATLQRLLAITQEASDTSWQALIDEDRLL 214
NT + Q ++ ++ L R+ L+ KL ++ + +AS T+ +A I + L
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ--LE 1820
Query: 215 SRLEVMGNQLQACSKN--QTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKL 272
+L+ + QA K +TE L+ L+ + +++ N E + + + +L
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE--------QYKDQADKASTRL 1872
Query: 273 SEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAE-----GK 327
+++R L E+E + Q EL + + E+ L +KL+ + +
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPR 1932
Query: 328 QEEIQQKGQAEKKELQHKIDEMEEKEQE 355
+ + G +E+ K D E K E
Sbjct: 1933 RMARKGAGDGSDEEVDGKADGAEAKPAE 1960
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 113 bits (282), Expect = 8e-25
Identities = 144/644 (22%), Positives = 278/644 (43%), Gaps = 63/644 (9%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS---- 228
++A + Q + +QR A + + W L + + L ++ ++QA
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 229 ----KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
+ Q ++ KEL E KH+ T K L+ LQ + E+ + E+ L+ +
Sbjct: 863 KTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 285 ECTH-LKEMNERTQEEL---RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
E L EM R +EE ++L + ++ DL ++L+ ++E +QK Q EK
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQLEKV 974
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
+ KI ++E++ + + L + ER++ L +L + E K
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----------EKAK 1023
Query: 401 KL--IVEGHLTKAVE-ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
L + H + E E +L KE ++R + L + D Q +L
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 458 PLAK--------VSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL 509
LAK ++ L D++ + ++ +E++ +L E + R ++ K + +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 510 LEEERKAYRNQVEE---STKQIQVLQAQL-QRLHIDTENLREEK---DSEITSTRDELLS 562
L EE +A + ++E+ ST Q L+A+ Q + + + L EE ++++ R +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 563 ARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQL 622
A +E+ + + + D + +L++E + EL +A E E + L+ Q
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 623 RCQQCEDQQREEAT------RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE 676
+C D +R A +LQ E+E + N E + L ++ LSS+LQ ++
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
L +Q L +++ L L+ R L++Q+ E + TL + + K +Q +
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-D 1382
Query: 737 YEKTQTVLSELKLKFE-----MTEQ--EKQSITDELKQCKNNLK 773
+ T L E K +F+ +T+Q EK + D+L++ KN L+
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Score = 101 bits (252), Expect = 2e-21
Identities = 150/672 (22%), Positives = 270/672 (40%), Gaps = 120/672 (17%)
Query: 152 KVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDED 211
K+A + S+ SQ L + LQE ++ + KL L+ Q+ D +A + +
Sbjct: 1305 KLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 212 RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK 271
R +S L + + SK + +D + AL+E K ++ E+L + +EK K
Sbjct: 1364 RHISTLNIQLSD----SKKKLQD-FASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDK 1417
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
L + + L D+ + + L + K++ + E K++S K + E
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 332 QQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTF 391
++ + + L ++E E ++EL+ TN+ L A E L+S
Sbjct: 1478 AREKETKALSLARALEEALEAKEELER-----------TNKMLKAEMEDLVSSKDDVGKN 1526
Query: 392 IHQFIECQKKLIVEGHLTK-----------AVEETKLSKENQTRAKESDFSDTLSPSKEK 440
+H+ + ++ L + K A E+ KL E +A + F L E+
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 441 SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + + LQ E E + E + ++ L A +
Sbjct: 1587 NEEK---------------------RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDEL 560
K ELQA A + + EE+ KQ++ LQAQ++ + E+ R
Sbjct: 1626 LKDLELQA-----DSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR-------------- 1665
Query: 561 LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEIT------ 614
++RDEI + K A + D+ LQE+L A ER RK A ++E+
Sbjct: 1666 -ASRDEIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQADLEKEELAEELASS 1720
Query: 615 -----SLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW-------NALETECHSL 659
+LQ+ + R Q E++ EE ++ +++RK N L TE S
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-RST 1779
Query: 660 KRENVLLSSELQRQEKELHNSQKQ-----SLELTSDLSILQMSRKELENQVGSLKEQHLR 714
++N +L+RQ KEL + + + S ++ L+ +LE QV EQ R
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV----EQEAR 1835
Query: 715 DSA-----------DLKTLLSKAENQ---AKDVQKEYEKTQTVLSELKLKFEMTEQEKQS 760
+ LK +L + E++ A+ +++ EK + +LK + E E+E Q
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 761 ITDELKQCKNNL 772
I ++ + L
Sbjct: 1896 INANRRKLQREL 1907
Score = 98.6 bits (244), Expect = 2e-20
Identities = 136/653 (20%), Positives = 280/653 (42%), Gaps = 82/653 (12%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
EL L Q QE H+++ LE ++ LQ + + A L ++ + N+
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA----------RAELNDKVHKLQNE 1288
Query: 224 LQACSK--NQTEDS---LRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
+++ + N+ E L K++ +L + + +E R +K+ V KL ++E
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR----QKLNVSTKLRQLEEE 1344
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
++ +D+ E + + + L + + + +++D + ++ E ++ Q++ +
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 339 KKELQHKI---DEMEEKEQELQAKIEALQADNDFTNE-------------RLTALQEHLL 382
++ + K D++E+ + LQ +++ L D D + +L A ++++
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE---SDFSDTLSPSKE 439
SK + E ++K L +A+EE +KE R + ++ D +S SK+
Sbjct: 1465 SKYADERDRAEA--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKD 1521
Query: 440 KSSDDTTDAQMD----EQDLNEPLAKVSLLKDDLQGAQ-SEIEAKQEIQHLRKELI-EAQ 493
+ + + E + E ++ L+D+LQ + +++ + +Q L+ + + Q
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
+++K +LQ L E Y ++E+ KQ + A ++L D ++L + DS I
Sbjct: 1582 ARDEQNEEKRRQLQRQLHE----YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 554 TSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI 613
R+E A K + + Q EL+ RA + A E EK+
Sbjct: 1638 --------KGREE-------AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQ 671
SL+ Q ED E R Q +LEK L +E + + ++L+ E L + +
Sbjct: 1683 KSLEADLM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 672 RQEKELHNSQKQSLELTSDLSILQMSRKELENQVG----------SLKEQHLRDSADLKT 721
+ E+EL Q ++ + ++L N++ S ++Q R + +L++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 722 LLSKAENQAKDVQKE-YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
L + E K K + +++L+ + E +EKQ+ T LKQ LK
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/743 (20%), Positives = 296/743 (39%), Gaps = 118/743 (15%)
Query: 133 MEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQR 191
M+ + + + A L D++A ++ +EL LQE L E+ K +R
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 192 LLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQE--DKH- 248
L EA T + +D L Q K ++ R +QE KH
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 249 ----------------------NYETTAKES------LRRVLQEKIEVVRKLSEVERSLS 280
N +T KE+ LR + Q K EV K ++E +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK------------- 327
+ +C+ ER + EL + +K NE++ ++ L AEGK
Sbjct: 1263 ELQSKCSD----GERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 328 ---------QEEIQQKG---------QAEKKELQHKIDEMEEKEQELQAKIEALQADNDF 369
QEE +QK + E+ LQ ++DE E +Q L+ I L
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK-----------LS 418
+ ++L + + G F + ++ + +E+TK +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 419 KENQTRA------KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA 472
+NQ + K+ F L+ K SS + E + E K L L+ A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 473 QSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ 532
+EAK+E++ K L E +SK + LE+ ++A Q+EE Q++ L+
Sbjct: 1496 ---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 533 AQLQ-------RLHIDTENLREEKDSEITSTRDELLSARDEI-LLLHQAAAKVASERDTD 584
+LQ RL ++ + L+ + + ++ + ++ R ++ LH+ ++ ER
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 585 IAS------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ--REEAT 636
+ L+ +LK + + + K E K++ LQ + ++ ED + R+E
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS---I 693
E EK K +LE + L+ + L ++E R++ +L ++ + EL S LS
Sbjct: 1673 ATAKENEKKAK---SLEADLMQLQED--LAAAERARKQADL-EKEELAEELASSLSGRNA 1726
Query: 694 LQMSRKELENQVGSLKEQHLRDSADLKTL---LSKAENQAKDVQKEYEKTQTVLSELKLK 750
LQ ++ LE ++ L+E+ + +++ + + KA QA+ + E ++ + +
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 751 FEMTEQEKQSITDELKQCKNNLK 773
+ E++ + + +L + + +K
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK 1809
Score = 89.7 bits (221), Expect = 1e-17
Identities = 115/519 (22%), Positives = 219/519 (42%), Gaps = 96/519 (18%)
Query: 265 KIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVA 324
K++ + +++ E + EDE KE ++ + EL+EL K++ E L ++L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 325 E---GKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL 381
+ EE++ + A+K+EL+ + EME + +E + + + LQA+ +++ L+E L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 382 LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS 441
+ ++KL +E K E K+ K D ++ LS ++
Sbjct: 960 EEEEAA-----------RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
+ +D + + E ++ LK+ + SE+E + L+KE QEL +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-----LKKEEKSRQELEK---- 1055
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
L+ LE + + Q+ + QI L+ QL + +EE+
Sbjct: 1056 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAK--------KEEE------------ 1091
Query: 562 SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
L A A++ D +IA LKK+R E E I+ LQ
Sbjct: 1092 --------LQAALARL----DDEIAQKNNALKKIR-----------ELEGHISDLQ---- 1124
Query: 622 LRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
ED E A R + E +K L +E AL+TE E+ L S+ Q++ +
Sbjct: 1125 ------EDLDSERAARNKAEKQKRDLGEELEALKTEL-----EDTLDSTATQQELRA--- 1170
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739
K+ E+T L + E QV ++++H + +L L + + ++ K +
Sbjct: 1171 --KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ ++L + + Q KQ + + K+ + ++ L+ K
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Score = 49.3 bits (116), Expect = 1e-05
Identities = 60/277 (21%), Positives = 122/277 (44%), Gaps = 31/277 (11%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRL---LSRLEVMGNQLQACSK 229
Q L +E++ E+ ++L A+ E + E+ L +E M ++++ +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT- 1763
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-SNTEDECTH 288
Q + L EL A + +A++ L R + E+ KL E+E ++ S +
Sbjct: 1764 -QQAEQLSNEL-ATERSTAQKNESARQQLER---QNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----------VAEGKQEEIQQKGQA 337
L+ + +E++ + A + A +K KLK +AE +E+ + KG A
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE-KGNA 1877
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQAD-------NDFTNERLTALQEHLLSKSGGDCT 390
K+L+ +++E EE+ Q + A LQ + N+ + AL+ L + G + +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL--RRGNETS 1935
Query: 391 FIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE 427
F+ +++I ++ +T+ + N T+A E
Sbjct: 1936 FVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1972
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 113 bits (282), Expect = 8e-25
Identities = 144/644 (22%), Positives = 278/644 (43%), Gaps = 63/644 (9%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS---- 228
++A + Q + +QR A + + W L + + L ++ ++QA
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 229 ----KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
+ Q ++ KEL E KH+ T K L+ LQ + E+ + E+ L+ +
Sbjct: 870 KTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 285 ECTH-LKEMNERTQEEL---RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
E L EM R +EE ++L + ++ DL ++L+ ++E +QK Q EK
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQLEKV 981
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
+ KI ++E++ + + L + ER++ L +L + E K
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----------EKAK 1030
Query: 401 KL--IVEGHLTKAVE-ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
L + H + E E +L KE ++R + L + D Q +L
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 458 PLAK--------VSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL 509
LAK ++ L D++ + ++ +E++ +L E + R ++ K + +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 510 LEEERKAYRNQVEE---STKQIQVLQAQL-QRLHIDTENLREEK---DSEITSTRDELLS 562
L EE +A + ++E+ ST Q L+A+ Q + + + L EE ++++ R +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 563 ARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQL 622
A +E+ + + + D + +L++E + EL +A E E + L+ Q
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 623 RCQQCEDQQREEAT------RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE 676
+C D +R A +LQ E+E + N E + L ++ LSS+LQ ++
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
L +Q L +++ L L+ R L++Q+ E + TL + + K +Q +
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-D 1389
Query: 737 YEKTQTVLSELKLKFE-----MTEQ--EKQSITDELKQCKNNLK 773
+ T L E K +F+ +T+Q EK + D+L++ KN L+
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Score = 101 bits (252), Expect = 2e-21
Identities = 150/672 (22%), Positives = 270/672 (40%), Gaps = 120/672 (17%)
Query: 152 KVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDED 211
K+A + S+ SQ L + LQE ++ + KL L+ Q+ D +A + +
Sbjct: 1312 KLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 212 RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK 271
R +S L + + SK + +D + AL+E K ++ E+L + +EK K
Sbjct: 1371 RHISTLNIQLSD----SKKKLQD-FASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDK 1424
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
L + + L D+ + + L + K++ + E K++S K + E
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 332 QQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTF 391
++ + + L ++E E ++EL+ TN+ L A E L+S
Sbjct: 1485 AREKETKALSLARALEEALEAKEELER-----------TNKMLKAEMEDLVSSKDDVGKN 1533
Query: 392 IHQFIECQKKLIVEGHLTK-----------AVEETKLSKENQTRAKESDFSDTLSPSKEK 440
+H+ + ++ L + K A E+ KL E +A + F L E+
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 441 SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + + LQ E E + E + ++ L A +
Sbjct: 1594 NEEK---------------------RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDEL 560
K ELQA A + + EE+ KQ++ LQAQ++ + E+ R
Sbjct: 1633 LKDLELQA-----DSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR-------------- 1672
Query: 561 LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEIT------ 614
++RDEI + K A + D+ LQE+L A ER RK A ++E+
Sbjct: 1673 -ASRDEIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQADLEKEELAEELASS 1727
Query: 615 -----SLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW-------NALETECHSL 659
+LQ+ + R Q E++ EE ++ +++RK N L TE S
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-RST 1786
Query: 660 KRENVLLSSELQRQEKELHNSQKQ-----SLELTSDLSILQMSRKELENQVGSLKEQHLR 714
++N +L+RQ KEL + + + S ++ L+ +LE QV EQ R
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV----EQEAR 1842
Query: 715 DSA-----------DLKTLLSKAENQ---AKDVQKEYEKTQTVLSELKLKFEMTEQEKQS 760
+ LK +L + E++ A+ +++ EK + +LK + E E+E Q
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 761 ITDELKQCKNNL 772
I ++ + L
Sbjct: 1903 INANRRKLQREL 1914
Score = 98.6 bits (244), Expect = 2e-20
Identities = 136/653 (20%), Positives = 280/653 (42%), Gaps = 82/653 (12%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
EL L Q QE H+++ LE ++ LQ + + A L ++ + N+
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA----------RAELNDKVHKLQNE 1295
Query: 224 LQACSK--NQTEDS---LRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
+++ + N+ E L K++ +L + + +E R +K+ V KL ++E
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR----QKLNVSTKLRQLEEE 1351
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
++ +D+ E + + + L + + + +++D + ++ E ++ Q++ +
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 339 KKELQHKI---DEMEEKEQELQAKIEALQADNDFTNE-------------RLTALQEHLL 382
++ + K D++E+ + LQ +++ L D D + +L A ++++
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE---SDFSDTLSPSKE 439
SK + E ++K L +A+EE +KE R + ++ D +S SK+
Sbjct: 1472 SKYADERDRAEA--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKD 1528
Query: 440 KSSDDTTDAQMD----EQDLNEPLAKVSLLKDDLQGAQ-SEIEAKQEIQHLRKELI-EAQ 493
+ + + E + E ++ L+D+LQ + +++ + +Q L+ + + Q
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
+++K +LQ L E Y ++E+ KQ + A ++L D ++L + DS I
Sbjct: 1589 ARDEQNEEKRRQLQRQLHE----YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 554 TSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI 613
R+E A K + + Q EL+ RA + A E EK+
Sbjct: 1645 --------KGREE-------AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQ 671
SL+ Q ED E R Q +LEK L +E + + ++L+ E L + +
Sbjct: 1690 KSLEADLM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 672 RQEKELHNSQKQSLELTSDLSILQMSRKELENQVG----------SLKEQHLRDSADLKT 721
+ E+EL Q ++ + ++L N++ S ++Q R + +L++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 722 LLSKAENQAKDVQKE-YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
L + E K K + +++L+ + E +EKQ+ T LKQ LK
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/743 (20%), Positives = 296/743 (39%), Gaps = 118/743 (15%)
Query: 133 MEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQR 191
M+ + + + A L D++A ++ +EL LQE L E+ K +R
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 192 LLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQE--DKH- 248
L EA T + +D L Q K ++ R +QE KH
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 249 ----------------------NYETTAKES------LRRVLQEKIEVVRKLSEVERSLS 280
N +T KE+ LR + Q K EV K ++E +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK------------- 327
+ +C+ ER + EL + +K NE++ ++ L AEGK
Sbjct: 1270 ELQSKCSD----GERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 328 ---------QEEIQQKG---------QAEKKELQHKIDEMEEKEQELQAKIEALQADNDF 369
QEE +QK + E+ LQ ++DE E +Q L+ I L
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK-----------LS 418
+ ++L + + G F + ++ + +E+TK +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 419 KENQTRA------KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA 472
+NQ + K+ F L+ K SS + E + E K L L+ A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 473 QSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ 532
+EAK+E++ K L E +SK + LE+ ++A Q+EE Q++ L+
Sbjct: 1503 ---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 533 AQLQ-------RLHIDTENLREEKDSEITSTRDELLSARDEI-LLLHQAAAKVASERDTD 584
+LQ RL ++ + L+ + + ++ + ++ R ++ LH+ ++ ER
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 585 IAS------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ--REEAT 636
+ L+ +LK + + + K E K++ LQ + ++ ED + R+E
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS---I 693
E EK K +LE + L+ + L ++E R++ +L ++ + EL S LS
Sbjct: 1680 ATAKENEKKAK---SLEADLMQLQED--LAAAERARKQADL-EKEELAEELASSLSGRNA 1733
Query: 694 LQMSRKELENQVGSLKEQHLRDSADLKTL---LSKAENQAKDVQKEYEKTQTVLSELKLK 750
LQ ++ LE ++ L+E+ + +++ + + KA QA+ + E ++ + +
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 751 FEMTEQEKQSITDELKQCKNNLK 773
+ E++ + + +L + + +K
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK 1816
Score = 89.7 bits (221), Expect = 1e-17
Identities = 115/519 (22%), Positives = 219/519 (42%), Gaps = 96/519 (18%)
Query: 265 KIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVA 324
K++ + +++ E + EDE KE ++ + EL+EL K++ E L ++L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 325 E---GKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL 381
+ EE++ + A+K+EL+ + EME + +E + + + LQA+ +++ L+E L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 382 LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS 441
+ ++KL +E K E K+ K D ++ LS ++
Sbjct: 967 EEEEAA-----------RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
+ +D + + E ++ LK+ + SE+E + L+KE QEL +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-----LKKEEKSRQELEK---- 1062
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
L+ LE + + Q+ + QI L+ QL + +EE+
Sbjct: 1063 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAK--------KEEE------------ 1098
Query: 562 SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
L A A++ D +IA LKK+R E E I+ LQ
Sbjct: 1099 --------LQAALARL----DDEIAQKNNALKKIR-----------ELEGHISDLQ---- 1131
Query: 622 LRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
ED E A R + E +K L +E AL+TE E+ L S+ Q++ +
Sbjct: 1132 ------EDLDSERAARNKAEKQKRDLGEELEALKTEL-----EDTLDSTATQQELRA--- 1177
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739
K+ E+T L + E QV ++++H + +L L + + ++ K +
Sbjct: 1178 --KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ ++L + + Q KQ + + K+ + ++ L+ K
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Score = 49.3 bits (116), Expect = 1e-05
Identities = 60/277 (21%), Positives = 122/277 (44%), Gaps = 31/277 (11%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRL---LSRLEVMGNQLQACSK 229
Q L +E++ E+ ++L A+ E + E+ L +E M ++++ +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT- 1770
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-SNTEDECTH 288
Q + L EL A + +A++ L R + E+ KL E+E ++ S +
Sbjct: 1771 -QQAEQLSNEL-ATERSTAQKNESARQQLER---QNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----------VAEGKQEEIQQKGQA 337
L+ + +E++ + A + A +K KLK +AE +E+ + KG A
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE-KGNA 1884
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQAD-------NDFTNERLTALQEHLLSKSGGDCT 390
K+L+ +++E EE+ Q + A LQ + N+ + AL+ L + G + +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL--RRGNETS 1942
Query: 391 FIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE 427
F+ +++I ++ +T+ + N T+A E
Sbjct: 1943 FVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1979
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 113 bits (282), Expect = 8e-25
Identities = 144/644 (22%), Positives = 278/644 (43%), Gaps = 63/644 (9%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS---- 228
++A + Q + +QR A + + W L + + L ++ ++QA
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 229 ----KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
+ Q ++ KEL E KH+ T K L+ LQ + E+ + E+ L+ +
Sbjct: 870 KTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 285 ECTH-LKEMNERTQEEL---RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
E L EM R +EE ++L + ++ DL ++L+ ++E +QK Q EK
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQLEKV 981
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
+ KI ++E++ + + L + ER++ L +L + E K
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----------EKAK 1030
Query: 401 KL--IVEGHLTKAVE-ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
L + H + E E +L KE ++R + L + D Q +L
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 458 PLAK--------VSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL 509
LAK ++ L D++ + ++ +E++ +L E + R ++ K + +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 510 LEEERKAYRNQVEE---STKQIQVLQAQL-QRLHIDTENLREEK---DSEITSTRDELLS 562
L EE +A + ++E+ ST Q L+A+ Q + + + L EE ++++ R +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 563 ARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQL 622
A +E+ + + + D + +L++E + EL +A E E + L+ Q
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 623 RCQQCEDQQREEAT------RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE 676
+C D +R A +LQ E+E + N E + L ++ LSS+LQ ++
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
L +Q L +++ L L+ R L++Q+ E + TL + + K +Q +
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-D 1389
Query: 737 YEKTQTVLSELKLKFE-----MTEQ--EKQSITDELKQCKNNLK 773
+ T L E K +F+ +T+Q EK + D+L++ KN L+
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Score = 101 bits (252), Expect = 2e-21
Identities = 150/672 (22%), Positives = 270/672 (40%), Gaps = 120/672 (17%)
Query: 152 KVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDED 211
K+A + S+ SQ L + LQE ++ + KL L+ Q+ D +A + +
Sbjct: 1312 KLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 212 RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK 271
R +S L + + SK + +D + AL+E K ++ E+L + +EK K
Sbjct: 1371 RHISTLNIQLSD----SKKKLQD-FASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDK 1424
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
L + + L D+ + + L + K++ + E K++S K + E
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 332 QQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTF 391
++ + + L ++E E ++EL+ TN+ L A E L+S
Sbjct: 1485 AREKETKALSLARALEEALEAKEELER-----------TNKMLKAEMEDLVSSKDDVGKN 1533
Query: 392 IHQFIECQKKLIVEGHLTK-----------AVEETKLSKENQTRAKESDFSDTLSPSKEK 440
+H+ + ++ L + K A E+ KL E +A + F L E+
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 441 SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + + LQ E E + E + ++ L A +
Sbjct: 1594 NEEK---------------------RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDEL 560
K ELQA A + + EE+ KQ++ LQAQ++ + E+ R
Sbjct: 1633 LKDLELQA-----DSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR-------------- 1672
Query: 561 LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEIT------ 614
++RDEI + K A + D+ LQE+L A ER RK A ++E+
Sbjct: 1673 -ASRDEIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQADLEKEELAEELASS 1727
Query: 615 -----SLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW-------NALETECHSL 659
+LQ+ + R Q E++ EE ++ +++RK N L TE S
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-RST 1786
Query: 660 KRENVLLSSELQRQEKELHNSQKQ-----SLELTSDLSILQMSRKELENQVGSLKEQHLR 714
++N +L+RQ KEL + + + S ++ L+ +LE QV EQ R
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV----EQEAR 1842
Query: 715 DSA-----------DLKTLLSKAENQ---AKDVQKEYEKTQTVLSELKLKFEMTEQEKQS 760
+ LK +L + E++ A+ +++ EK + +LK + E E+E Q
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 761 ITDELKQCKNNL 772
I ++ + L
Sbjct: 1903 INANRRKLQREL 1914
Score = 98.6 bits (244), Expect = 2e-20
Identities = 136/653 (20%), Positives = 280/653 (42%), Gaps = 82/653 (12%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
EL L Q QE H+++ LE ++ LQ + + A L ++ + N+
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA----------RAELNDKVHKLQNE 1295
Query: 224 LQACSK--NQTEDS---LRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
+++ + N+ E L K++ +L + + +E R +K+ V KL ++E
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR----QKLNVSTKLRQLEEE 1351
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
++ +D+ E + + + L + + + +++D + ++ E ++ Q++ +
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 339 KKELQHKI---DEMEEKEQELQAKIEALQADNDFTNE-------------RLTALQEHLL 382
++ + K D++E+ + LQ +++ L D D + +L A ++++
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE---SDFSDTLSPSKE 439
SK + E ++K L +A+EE +KE R + ++ D +S SK+
Sbjct: 1472 SKYADERDRAEA--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKD 1528
Query: 440 KSSDDTTDAQMD----EQDLNEPLAKVSLLKDDLQGAQ-SEIEAKQEIQHLRKELI-EAQ 493
+ + + E + E ++ L+D+LQ + +++ + +Q L+ + + Q
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
+++K +LQ L E Y ++E+ KQ + A ++L D ++L + DS I
Sbjct: 1589 ARDEQNEEKRRQLQRQLHE----YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 554 TSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI 613
R+E A K + + Q EL+ RA + A E EK+
Sbjct: 1645 --------KGREE-------AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQ 671
SL+ Q ED E R Q +LEK L +E + + ++L+ E L + +
Sbjct: 1690 KSLEADLM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 672 RQEKELHNSQKQSLELTSDLSILQMSRKELENQVG----------SLKEQHLRDSADLKT 721
+ E+EL Q ++ + ++L N++ S ++Q R + +L++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 722 LLSKAENQAKDVQKE-YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
L + E K K + +++L+ + E +EKQ+ T LKQ LK
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/743 (20%), Positives = 296/743 (39%), Gaps = 118/743 (15%)
Query: 133 MEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQR 191
M+ + + + A L D++A ++ +EL LQE L E+ K +R
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 192 LLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQE--DKH- 248
L EA T + +D L Q K ++ R +QE KH
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 249 ----------------------NYETTAKES------LRRVLQEKIEVVRKLSEVERSLS 280
N +T KE+ LR + Q K EV K ++E +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK------------- 327
+ +C+ ER + EL + +K NE++ ++ L AEGK
Sbjct: 1270 ELQSKCSD----GERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 328 ---------QEEIQQKG---------QAEKKELQHKIDEMEEKEQELQAKIEALQADNDF 369
QEE +QK + E+ LQ ++DE E +Q L+ I L
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK-----------LS 418
+ ++L + + G F + ++ + +E+TK +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 419 KENQTRA------KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA 472
+NQ + K+ F L+ K SS + E + E K L L+ A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 473 QSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ 532
+EAK+E++ K L E +SK + LE+ ++A Q+EE Q++ L+
Sbjct: 1503 ---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 533 AQLQ-------RLHIDTENLREEKDSEITSTRDELLSARDEI-LLLHQAAAKVASERDTD 584
+LQ RL ++ + L+ + + ++ + ++ R ++ LH+ ++ ER
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 585 IAS------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ--REEAT 636
+ L+ +LK + + + K E K++ LQ + ++ ED + R+E
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS---I 693
E EK K +LE + L+ + L ++E R++ +L ++ + EL S LS
Sbjct: 1680 ATAKENEKKAK---SLEADLMQLQED--LAAAERARKQADL-EKEELAEELASSLSGRNA 1733
Query: 694 LQMSRKELENQVGSLKEQHLRDSADLKTL---LSKAENQAKDVQKEYEKTQTVLSELKLK 750
LQ ++ LE ++ L+E+ + +++ + + KA QA+ + E ++ + +
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 751 FEMTEQEKQSITDELKQCKNNLK 773
+ E++ + + +L + + +K
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK 1816
Score = 89.7 bits (221), Expect = 1e-17
Identities = 115/519 (22%), Positives = 219/519 (42%), Gaps = 96/519 (18%)
Query: 265 KIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVA 324
K++ + +++ E + EDE KE ++ + EL+EL K++ E L ++L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 325 E---GKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL 381
+ EE++ + A+K+EL+ + EME + +E + + + LQA+ +++ L+E L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 382 LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS 441
+ ++KL +E K E K+ K D ++ LS ++
Sbjct: 967 EEEEAA-----------RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
+ +D + + E ++ LK+ + SE+E + L+KE QEL +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-----LKKEEKSRQELEK---- 1062
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
L+ LE + + Q+ + QI L+ QL + +EE+
Sbjct: 1063 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAK--------KEEE------------ 1098
Query: 562 SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
L A A++ D +IA LKK+R E E I+ LQ
Sbjct: 1099 --------LQAALARL----DDEIAQKNNALKKIR-----------ELEGHISDLQ---- 1131
Query: 622 LRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
ED E A R + E +K L +E AL+TE E+ L S+ Q++ +
Sbjct: 1132 ------EDLDSERAARNKAEKQKRDLGEELEALKTEL-----EDTLDSTATQQELRA--- 1177
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739
K+ E+T L + E QV ++++H + +L L + + ++ K +
Sbjct: 1178 --KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ ++L + + Q KQ + + K+ + ++ L+ K
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/220 (23%), Positives = 98/220 (44%), Gaps = 22/220 (10%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRL---LSRLEVMGNQLQACSK 229
Q L +E++ E+ ++L A+ E + E+ L +E M ++++ +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT- 1770
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-SNTEDECTH 288
Q + L EL A + +A++ L R + E+ KL E+E ++ S +
Sbjct: 1771 -QQAEQLSNEL-ATERSTAQKNESARQQLER---QNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----------VAEGKQEEIQQKGQA 337
L+ + +E++ + A + A +K KLK +AE +E+ + KG A
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE-KGNA 1884
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTAL 377
K+L+ +++E EE+ Q + A LQ + D E A+
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 32.0 bits (71), Expect = 2.4
Identities = 30/151 (19%), Positives = 63/151 (41%), Gaps = 10/151 (6%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKN-Q 231
Q+ + + L KL ++ + +++ + +A I + L ++E + QA +K+ +
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEAREKQAATKSLK 1852
Query: 232 TEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKE 291
+D KE++ ED+ KE + ++ +++R L E+E +
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-------RVKQLKRQLEEAEEESQRINA 1905
Query: 292 MNERTQEELRELANKYNGAVNEIKDLSDKLK 322
+ Q EL E E+ L KL+
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 113 bits (282), Expect = 8e-25
Identities = 144/644 (22%), Positives = 278/644 (43%), Gaps = 63/644 (9%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS---- 228
++A + Q + +QR A + + W L + + L ++ ++QA
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 229 ----KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
+ Q ++ KEL E KH+ T K L+ LQ + E+ + E+ L+ +
Sbjct: 863 KTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 285 ECTH-LKEMNERTQEEL---RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
E L EM R +EE ++L + ++ DL ++L+ ++E +QK Q EK
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQLEKV 974
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
+ KI ++E++ + + L + ER++ L +L + E K
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----------EKAK 1023
Query: 401 KL--IVEGHLTKAVE-ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
L + H + E E +L KE ++R + L + D Q +L
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 458 PLAK--------VSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL 509
LAK ++ L D++ + ++ +E++ +L E + R ++ K + +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 510 LEEERKAYRNQVEE---STKQIQVLQAQL-QRLHIDTENLREEK---DSEITSTRDELLS 562
L EE +A + ++E+ ST Q L+A+ Q + + + L EE ++++ R +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 563 ARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQL 622
A +E+ + + + D + +L++E + EL +A E E + L+ Q
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 623 RCQQCEDQQREEAT------RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE 676
+C D +R A +LQ E+E + N E + L ++ LSS+LQ ++
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
L +Q L +++ L L+ R L++Q+ E + TL + + K +Q +
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-D 1382
Query: 737 YEKTQTVLSELKLKFE-----MTEQ--EKQSITDELKQCKNNLK 773
+ T L E K +F+ +T+Q EK + D+L++ KN L+
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Score = 101 bits (252), Expect = 2e-21
Identities = 150/672 (22%), Positives = 270/672 (40%), Gaps = 120/672 (17%)
Query: 152 KVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDED 211
K+A + S+ SQ L + LQE ++ + KL L+ Q+ D +A + +
Sbjct: 1305 KLAKDVASLSSQ-LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 212 RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK 271
R +S L + + SK + +D + AL+E K ++ E+L + +EK K
Sbjct: 1364 RHISTLNIQLSD----SKKKLQD-FASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDK 1417
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
L + + L D+ + + L + K++ + E K++S K + E
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 332 QQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTF 391
++ + + L ++E E ++EL+ TN+ L A E L+S
Sbjct: 1478 AREKETKALSLARALEEALEAKEELER-----------TNKMLKAEMEDLVSSKDDVGKN 1526
Query: 392 IHQFIECQKKLIVEGHLTK-----------AVEETKLSKENQTRAKESDFSDTLSPSKEK 440
+H+ + ++ L + K A E+ KL E +A + F L E+
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 441 SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + + LQ E E + E + ++ L A +
Sbjct: 1587 NEEK---------------------RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDEL 560
K ELQA A + + EE+ KQ++ LQAQ++ + E+ R
Sbjct: 1626 LKDLELQA-----DSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR-------------- 1665
Query: 561 LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEIT------ 614
++RDEI + K A + D+ LQE+L A ER RK A ++E+
Sbjct: 1666 -ASRDEIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQADLEKEELAEELASS 1720
Query: 615 -----SLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW-------NALETECHSL 659
+LQ+ + R Q E++ EE ++ +++RK N L TE S
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE-RST 1779
Query: 660 KRENVLLSSELQRQEKELHNSQKQ-----SLELTSDLSILQMSRKELENQVGSLKEQHLR 714
++N +L+RQ KEL + + + S ++ L+ +LE QV EQ R
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV----EQEAR 1835
Query: 715 DSA-----------DLKTLLSKAENQ---AKDVQKEYEKTQTVLSELKLKFEMTEQEKQS 760
+ LK +L + E++ A+ +++ EK + +LK + E E+E Q
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 761 ITDELKQCKNNL 772
I ++ + L
Sbjct: 1896 INANRRKLQREL 1907
Score = 98.6 bits (244), Expect = 2e-20
Identities = 136/653 (20%), Positives = 280/653 (42%), Gaps = 82/653 (12%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
EL L Q QE H+++ LE ++ LQ + + A L ++ + N+
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA----------RAELNDKVHKLQNE 1288
Query: 224 LQACSK--NQTEDS---LRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
+++ + N+ E L K++ +L + + +E R +K+ V KL ++E
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR----QKLNVSTKLRQLEEE 1344
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
++ +D+ E + + + L + + + +++D + ++ E ++ Q++ +
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 339 KKELQHKI---DEMEEKEQELQAKIEALQADNDFTNE-------------RLTALQEHLL 382
++ + K D++E+ + LQ +++ L D D + +L A ++++
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE---SDFSDTLSPSKE 439
SK + E ++K L +A+EE +KE R + ++ D +S SK+
Sbjct: 1465 SKYADERDRAEA--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS-SKD 1521
Query: 440 KSSDDTTDAQMD----EQDLNEPLAKVSLLKDDLQGAQ-SEIEAKQEIQHLRKELI-EAQ 493
+ + + E + E ++ L+D+LQ + +++ + +Q L+ + + Q
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
+++K +LQ L E Y ++E+ KQ + A ++L D ++L + DS I
Sbjct: 1582 ARDEQNEEKRRQLQRQLHE----YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 554 TSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI 613
R+E A K + + Q EL+ RA + A E EK+
Sbjct: 1638 --------KGREE-------AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQ 671
SL+ Q ED E R Q +LEK L +E + + ++L+ E L + +
Sbjct: 1683 KSLEADLM---QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 672 RQEKELHNSQKQSLELTSDLSILQMSRKELENQVG----------SLKEQHLRDSADLKT 721
+ E+EL Q ++ + ++L N++ S ++Q R + +L++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 722 LLSKAENQAKDVQKE-YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
L + E K K + +++L+ + E +EKQ+ T LKQ LK
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/743 (20%), Positives = 296/743 (39%), Gaps = 118/743 (15%)
Query: 133 MEARLRSDVIHAPLPSPVDKVAANTPSMYS-QELFQLSQYLQEALHREQMLEQKLATLQR 191
M+ + + + A L D++A ++ +EL LQE L E+ K +R
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 192 LLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQE--DKH- 248
L EA T + +D L Q K ++ R +QE KH
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 249 ----------------------NYETTAKES------LRRVLQEKIEVVRKLSEVERSLS 280
N +T KE+ LR + Q K EV K ++E +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK------------- 327
+ +C+ ER + EL + +K NE++ ++ L AEGK
Sbjct: 1263 ELQSKCSD----GERARAELNDKVHKLQ---NEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 328 ---------QEEIQQKG---------QAEKKELQHKIDEMEEKEQELQAKIEALQADNDF 369
QEE +QK + E+ LQ ++DE E +Q L+ I L
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK-----------LS 418
+ ++L + + G F + ++ + +E+TK +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 419 KENQTRA------KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA 472
+NQ + K+ F L+ K SS + E + E K L L+ A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 473 QSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ 532
+EAK+E++ K L E +SK + LE+ ++A Q+EE Q++ L+
Sbjct: 1496 ---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 533 AQLQ-------RLHIDTENLREEKDSEITSTRDELLSARDEI-LLLHQAAAKVASERDTD 584
+LQ RL ++ + L+ + + ++ + ++ R ++ LH+ ++ ER
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 585 IAS------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ--REEAT 636
+ L+ +LK + + + K E K++ LQ + ++ ED + R+E
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS---I 693
E EK K +LE + L+ + L ++E R++ +L ++ + EL S LS
Sbjct: 1673 ATAKENEKKAK---SLEADLMQLQED--LAAAERARKQADL-EKEELAEELASSLSGRNA 1726
Query: 694 LQMSRKELENQVGSLKEQHLRDSADLKTL---LSKAENQAKDVQKEYEKTQTVLSELKLK 750
LQ ++ LE ++ L+E+ + +++ + + KA QA+ + E ++ + +
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 751 FEMTEQEKQSITDELKQCKNNLK 773
+ E++ + + +L + + +K
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK 1809
Score = 89.7 bits (221), Expect = 1e-17
Identities = 115/519 (22%), Positives = 219/519 (42%), Gaps = 96/519 (18%)
Query: 265 KIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVA 324
K++ + +++ E + EDE KE ++ + EL+EL K++ E L ++L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 325 E---GKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL 381
+ EE++ + A+K+EL+ + EME + +E + + + LQA+ +++ L+E L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 382 LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS 441
+ ++KL +E K E K+ K D ++ LS ++
Sbjct: 960 EEEEAA-----------RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
+ +D + + E ++ LK+ + SE+E + L+KE QEL +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-----LKKEEKSRQELEK---- 1055
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
L+ LE + + Q+ + QI L+ QL + +EE+
Sbjct: 1056 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAK--------KEEE------------ 1091
Query: 562 SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
L A A++ D +IA LKK+R E E I+ LQ
Sbjct: 1092 --------LQAALARL----DDEIAQKNNALKKIR-----------ELEGHISDLQ---- 1124
Query: 622 LRCQQCEDQQREEATRLQGELEK--LRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
ED E A R + E +K L +E AL+TE E+ L S+ Q++ +
Sbjct: 1125 ------EDLDSERAARNKAEKQKRDLGEELEALKTEL-----EDTLDSTATQQELRA--- 1170
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739
K+ E+T L + E QV ++++H + +L L + + ++ K +
Sbjct: 1171 --KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ ++L + + Q KQ + + K+ + ++ L+ K
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/220 (23%), Positives = 98/220 (44%), Gaps = 22/220 (10%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRL---LSRLEVMGNQLQACSK 229
Q L +E++ E+ ++L A+ E + E+ L +E M ++++ +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT- 1763
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL-SNTEDECTH 288
Q + L EL A + +A++ L R + E+ KL E+E ++ S +
Sbjct: 1764 -QQAEQLSNEL-ATERSTAQKNESARQQLER---QNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----------VAEGKQEEIQQKGQA 337
L+ + +E++ + A + A +K KLK +AE +E+ + KG A
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE-KGNA 1877
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTAL 377
K+L+ +++E EE+ Q + A LQ + D E A+
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 32.0 bits (71), Expect = 2.4
Identities = 30/151 (19%), Positives = 63/151 (41%), Gaps = 10/151 (6%)
Query: 173 QEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKN-Q 231
Q+ + + L KL ++ + +++ + +A I + L ++E + QA +K+ +
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEAREKQAATKSLK 1845
Query: 232 TEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKE 291
+D KE++ ED+ KE + ++ +++R L E+E +
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNA-------RVKQLKRQLEEAEEESQRINA 1898
Query: 292 MNERTQEELRELANKYNGAVNEIKDLSDKLK 322
+ Q EL E E+ L KL+
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 112 bits (281), Expect = 1e-24
Identities = 150/633 (23%), Positives = 293/633 (46%), Gaps = 72/633 (11%)
Query: 164 ELFQLSQY--LQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLL------- 214
EL Q+S+ L EA + E T RLL + E + S ++E R
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME--NQSLTKTVEELRTTVDSVEGN 489
Query: 215 -SRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRV--LQEKIEVVRK 271
S++ M + Q SK + L E++ ++ N + +K+ ++ L++ IE +R+
Sbjct: 490 ASKILKMEKENQRLSKKV--EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELAN-KYNGAVNEIKDLSDKLKVAEGKQEE 330
SE R + E E HL + ++ + A + E K L + +K K +
Sbjct: 548 NSE--RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 331 IQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCT 390
I+ + + KKEL+H E E+ +EL+ ++ L+ +N+ +++T L+
Sbjct: 606 IEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKITNLK------------ 652
Query: 391 FIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQM 450
I C+K +E E ++L +EN+ K D L+ E S + ++Q+
Sbjct: 653 -----ITCEKIEALEQ------ENSELERENRKLKKTLDSFKNLTFQLE--SLEKENSQL 699
Query: 451 DEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL- 509
DE++L SL ++ AQ ++E K E++ +++L + EL + S +K L+
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 510 --LEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELLSARDE 566
L+ E + + +E S K+IQ L+++LQ L ++ + L++ ++ +I+S R E L ++
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 567 ILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQ 626
L + S+ + D L++E K++R + E E +I +L+ + ++
Sbjct: 819 SL------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 627 CEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
+E RL+ ELEK KE +KR + + + + +E +L + + ++ +
Sbjct: 873 I-GIYKESCVRLK-ELEKENKEL---------VKRATIDIKTLVTLRE-DLVSEKLKTQQ 920
Query: 687 LTSDLSILQMSRKELE-NQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLS 745
+ +DL L +++ N+ L ++ D + K L SK E+ K K E + ++
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLK---KSLEIKEEKIA 977
Query: 746 ELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
L+ + E + Q + ELK K N + L+++
Sbjct: 978 ALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Score = 109 bits (272), Expect = 1e-23
Identities = 148/728 (20%), Positives = 313/728 (42%), Gaps = 122/728 (16%)
Query: 144 APLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTS 203
A + + + +V N +++ + +++ QE + E +L+ L+RL+ E S+T
Sbjct: 154 AAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDI--EPLLKNMALHLKRLIDERDEHSETI 211
Query: 204 WQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQ 263
+ + D L + C + + ++ ++++ AK +RR+ Q
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL------ADAKAKIRRLRQ 265
Query: 264 EKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEE-------------LRELA---NKY 307
E E +L + ++ L E E L++ N + LRE A +K
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKL 325
Query: 308 NGAVNEIKDLSDKLKVAEGKQEEIQQKGQA--EKKEL-----------QHKIDEMEEKEQ 354
V+ K+ ++ + + EE+++ Q E K + K+ E+E++
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENL 385
Query: 355 ELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEE 414
+L+AK+ ++ + D +++ L E ++ +E +K ++ L E
Sbjct: 386 QLKAKLHDMEMERDMDRKKIEELMEENMT------------LEMAQKQSMDESLHLGWEL 433
Query: 415 TKLSKENQ-TRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQ 473
++S+ ++ + A + ++ E +S +M+ Q L + + ++ D ++G
Sbjct: 434 EQISRTSELSEAPQKSLGHEVN---ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 474 SEI-EAKQEIQHLRK--ELIEAQELA-RTSKQKCFELQALLEEERKAYRNQVE----EST 525
S+I + ++E Q L K E++E + + + S Q C L L +E+ +E S
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 526 KQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDI 585
+QI++L+ + + L+ +LR+ S + E +LH++ + +S+ +
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQ---ISAEARVKDIEKENKILHESIKETSSK----L 603
Query: 586 ASLQEELKKVRAELERWRKA---ASEYEKEITSLQN----------SFQLRCQQCE--DQ 630
+ ++ E ++++ ELE +++ A E E E+ L+ + ++ C++ E +Q
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 631 QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSE--------------------L 670
+ E R +L+K + L + SL++EN L E L
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTL------LS 724
Q + KEL + ++Q L L +L+ S K+ E S + + + KTL +
Sbjct: 724 QLENKELESEKEQ---LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 725 KAENQAKDVQKEYEKTQTVLSELKL---KFEMTEQEKQSITDEL-------KQCKNNLKL 774
+ E++ +D++ E + Q L ELK+ + E E+E +S+ E KQ + K
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 775 LREKGNNK 782
LR++ K
Sbjct: 841 LRQQAEIK 848
Score = 91.3 bits (225), Expect = 3e-18
Identities = 148/700 (21%), Positives = 283/700 (40%), Gaps = 109/700 (15%)
Query: 129 LPDGMEARLRSDVIHAPLPSPV--DKVAANTPSMYSQELFQLSQY---LQEALHREQMLE 183
L D AR+ D + A V DK+ + S Y + L + Y ++E Q+L
Sbjct: 299 LSDARSARMYRDELDALREKAVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 184 QKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIAL 243
+ L+ L T+ SD + + +L ++L M D RK++ L
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM---------EMERDMDRKKIEEL 408
Query: 244 QEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL-KEMNERTQEELRE 302
E+ E K+S+ E + + +L ++ R+ +E L E+NE T L +
Sbjct: 409 MEENMTLEMAQKQSM----DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 303 LANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEA 362
L + +++L + EG KI +ME++ Q L K+E
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNAS---------------KILKMEKENQRLSKKVEI 509
Query: 363 LQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQ 422
L+ N+ E+ + LSK + K+ + L K +E + + E Q
Sbjct: 510 LE--NEIVQEKQSLQNCQNLSK------------DLMKE---KAQLEKTIETLRENSERQ 552
Query: 423 TRAKESD---FSDTLSPSKEKSS--------DDTTDAQMDEQDLNEPLAKVSLLKDDLQG 471
+ E + + T+S +++S D + ++ + + E +K+S ++ + +
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 472 AQSEIE-----------AKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQ 520
+ E+E + E+ HL KE Q+ K C +++AL +E ++
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN-----SE 667
Query: 521 VEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASE 580
+E ++++ + L E+L +E + +E L R + L A+ K+A
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKEN----SQLDEENLELRRNVESLKCASMKMAQL 723
Query: 581 R--DTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRL 638
+ + ++ S +E+LKK L+ K E L Q R Q+ + ++ +L
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-RLQKTLENSNKKIQQL 782
Query: 639 QGELEKLRKEWNALETECHSLK----------RENVLLSSELQRQEKELHNSQKQSLELT 688
+ EL+ L E L+ LK +EN L E + EK+ +K++ L
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 689 SDLSILQMSRKELENQVGSLKEQHLRDSADLK------TLLSKAENQAKDVQKEYE---K 739
I + +E ++G+L++++ S ++ L + E + K++ K K
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 740 TQTVLSE----LKLKFEMTEQEKQSITDELKQCKNNLKLL 775
T L E KLK + + + +T EL++ N + L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Score = 65.5 bits (158), Expect = 2e-10
Identities = 123/609 (20%), Positives = 245/609 (40%), Gaps = 121/609 (19%)
Query: 178 REQMLEQKLATLQR---LLAITQEASDTSWQALIDEDRLL--------SRLEVMGNQLQA 226
RE ++ +KL T Q L +T E ++++RLL SR +++ ++L++
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIG----LNKERLLHDEQSTDDSRYKLLESKLES 963
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQ---EKIEVVRKLSEVERSLSNTE 283
K E +++E IA E + T + LR+ L+ + E +++ + ER + ++
Sbjct: 964 TLKKSLE--IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
Query: 284 DECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQ 343
+ +QE REL + D+L E +Q AEK+ L+
Sbjct: 1022 PISGEDNKWERESQETTRELLK-----------VKDRLIEVERNNATLQ----AEKQALK 1066
Query: 344 HKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLI 403
++ ++E + LQA+I ALQ E+ T LQ
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ------------------------- 1101
Query: 404 VEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS 463
+ KL EN T +S +S +AQ+ L + S
Sbjct: 1102 --------TQNAKLQVENSTLNSQS------------TSLMNQNAQL--------LIQQS 1133
Query: 464 LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEE 523
L+++ + S I+ +++++ L LI+ E +L+ L E + Y + + +
Sbjct: 1134 SLENENE---SVIKEREDLKSLYDSLIKDHE----------KLELLHERQASEYESLISK 1180
Query: 524 STKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDT 583
L++ + L ++ +L E++ +++ + + L +++L + Q + ++
Sbjct: 1181 H----GTLKSAHKNLEVEHRDL-EDRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHE 1234
Query: 584 DIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELE 643
+A+ E KK+ E +R S+ KE LQ + + + + E TRL+ E
Sbjct: 1235 TVAA---EYKKLCGENDRLNHTYSQLLKETEVLQTDHK-NLKSLLNNSKLEQTRLEAEFS 1290
Query: 644 KLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELEN 703
KL++++ L+ L + LLS E+E + Q L L E ++
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Query: 704 QVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK----------TQTVLSELKLKFEM 753
+ Q++ +L+ K E + D K Y+ T + +K K ++
Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDI 1410
Query: 754 TEQEKQSIT 762
+ ++S+T
Sbjct: 1411 NRERQKSLT 1419
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 112 bits (279), Expect = 2e-24
Identities = 137/603 (22%), Positives = 259/603 (42%), Gaps = 66/603 (10%)
Query: 243 LQEDKHNYETTAK-ESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE--- 298
LQ + E AK E L +V +++ +V +L E+ER +E L E + E
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 299 ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQA 358
E E+ + E++++ L+ ++EE Q Q EKK++Q I ++EE+ E +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 359 KIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQ-------FIECQKKLIVEGHLTKA 411
+ LQ + ++ ++E +L + FI + EC +L E K
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 412 V------EETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSL- 464
+ +E +S + KE L +K K +TTD Q +L + ++ L
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 465 ---LKDDLQGA-----------QSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALL 510
+++LQGA + ++ +E+Q EL E E + S+ K + + L
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 511 EEERKAYRNQVE---ESTKQIQVLQAQLQRLHIDTENLREEK----DSEITSTRDELLSA 563
EE +A + ++E ++T Q L+ + ++ + + EE+ +++I R +A
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 564 RDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLR 623
+E+ + A + + + + L+ + K++ E++ ++ +E E + L Q
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 624 CQQCEDQQR------EEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKEL 677
+ + R E+A++LQ EL+ + E + ++ L S+LQ ++ L
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL 1324
Query: 678 HNSQKQSLELTSDLSIL--------------QMSRKELENQVGSLKEQHLRDSA-----D 718
+Q L L+S + L + +RK LE QV +L+ Q L D+ D
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ-LADTKKKVDDD 1383
Query: 719 LKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
L T+ S E K + K+ E L E L ++ E+ K + EL +L R+
Sbjct: 1384 LGTIES-LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 779 GNN 781
+N
Sbjct: 1443 ASN 1445
Score = 107 bits (268), Expect = 3e-23
Identities = 157/695 (22%), Positives = 297/695 (42%), Gaps = 113/695 (16%)
Query: 162 SQELFQLSQYLQEALHR---EQML----EQKLATLQRLLAITQEASDTSWQALIDEDRLL 214
S+EL L L++ L +Q L EQ++A L++ A+ +E + Q R
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK--ALEEETKNHEAQIQDMRQRHA 1202
Query: 215 SRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSE 274
+ LE + QL+ + + L+++K ET KE V + ++ V+ SE
Sbjct: 1203 TALEELSEQLEQAKRFKAN---------LEKNKQGLETDNKELACEV--KVLQQVKAESE 1251
Query: 275 VERSLSNTEDECTHLK-EMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK------ 327
+R + + + H K +R + EL E A+K NE+ ++S L+ AE K
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ---NELDNVSTLLEEAEKKGIKFAK 1308
Query: 328 -----------QEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTA 376
+E+ Q+ +K L +I ++EE++ LQ + E + +++ A
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 377 LQEHLLS---KSGGDCTFIHQFIECQKKLIVEGH-LTKAVEETKLSKENQTRAK------ 426
LQ L K D I E +KKL+ + L++ +EE L+ + + K
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 427 ---------------------ESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLL 465
+ F L+ K S+ + E + E K L
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 466 KDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEEST 525
L+ A +EAK+E + K+L E +SK + LE+ ++A QVEE
Sbjct: 1489 ARALEEA---LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 526 KQIQVLQAQLQ-------RLHIDTENLREEKDSEITSTRDELLSARDEILL--LHQAAAK 576
Q++ L+ +LQ RL ++ + ++ + + ++ TRDE + +L+ + + A+
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 577 VASERD---TDIAS---LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQ 630
+ ER +AS ++ +LK + A++E KA E K++ LQ Q +D
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ-------AQMKDY 1657
Query: 631 QR--EEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELT 688
QR EEA + E+ KE E + SL+ E + L EL E+ +++++ EL
Sbjct: 1658 QRELEEARASRDEIFAQSKE---SEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 689 SDL-------SILQMSRKELENQVGSLKEQHLRDSADLKTL---LSKAENQAKDVQKEYE 738
++ S L ++ LE ++ L+E+ + ++++ L K Q + E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 739 KTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
++ + + E++ + + +L++ + +K
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Score = 104 bits (260), Expect = 3e-22
Identities = 146/632 (23%), Positives = 284/632 (44%), Gaps = 61/632 (9%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
EL ++ + Q+ L + +L ++L L A +E + + +L LE +
Sbjct: 874 ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933
Query: 224 LQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQ-EKIEVVRKLSEVERSLSNT 282
+ +NQ + +K++ A +D + +E R+ LQ EK+ K+ ++E +
Sbjct: 934 EE--ERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990
Query: 283 EDECTHL----KEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
ED+ + K M +R E +LA + A N K + +K +V EE +K +
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK-IRNKQEVMISDLEERLKKEEKT 1049
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLL-SKSGGDCTFIHQFIE 397
++EL+ +++ + +LQ +I LQA D +L +E L + + GD +H+
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 398 CQKKLIVEGHLTKAVE--ETKLSKENQTRAKESDFSDTLSPSKEKSSD--DTTDAQMDEQ 453
+ ++ + + E E++ + N+ ++ D S+ L K + D DTT AQ + +
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 454 DLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEE 513
E +V+ LK L+ EA +IQ +R+ A E ++ +A LE+
Sbjct: 1170 TKRE--QEVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 514 RKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQA 573
++ +E +++V LQ++ ++E+ R++ D+++ EL + E L
Sbjct: 1226 KQGLETDNKELACEVKV----LQQVKAESEHKRKKLDAQV----QELHAKVSEGDRLRVE 1277
Query: 574 AAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQRE 633
A+ AS+ LQ EL V LE K ++ K+ SL++ Q Q+ ++
Sbjct: 1278 LAEKASK-------LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ-DTQELLQEETR 1329
Query: 634 EATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELH-NSQKQSLELTSDLS 692
+ L + +L +E N+L+ E Q +E+E N +KQ L L S L+
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQ---------------EQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 693 ILQMSRKELENQVGSL------KEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSE 746
++K++++ +G++ K++ L+D+ L L + ++K + Q L +
Sbjct: 1375 ---DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 747 LKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
L + + Q ++ E KQ K + L EK
Sbjct: 1432 LTVDLDHQRQVASNL--EKKQKKFDQLLAEEK 1461
Score = 100 bits (249), Expect = 5e-21
Identities = 152/703 (21%), Positives = 305/703 (43%), Gaps = 106/703 (15%)
Query: 151 DKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLL-AITQEASD--TSWQAL 207
++ A N + +++ +S L+E L +E+ Q+L +R L T + D QA
Sbjct: 1019 EEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 208 IDEDRLLSRLEVMGNQLQACSKNQTEDSLRK------------ELIALQEDKHNYETTAK 255
IDE +L +L +LQ +++L K ++ LQED + K
Sbjct: 1078 IDELKL--QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE----SEK 1131
Query: 256 ESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIK 315
S + ++K ++ +L ++ L +T D +E+ + ++E+ EL K
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK----------K 1181
Query: 316 DLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLT 375
L ++ K E + ++++Q+ +EL ++++ + + L+ + L+ DN +
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 376 ALQ------EHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESD 429
LQ EH K +H + +L VE L + + + +N + E
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE--LAEKASKLQNELDNVSTLLEEA 1299
Query: 430 FSDTLSPSKEKSS-----DDTTDAQMDE--QDLNEPLAKVSLLKDDLQGAQSEIEAKQEI 482
+ +K+ +S DT + +E Q LN +++ L+++ Q + E ++E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS-SRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 483 -QHLRKELIEAQ-ELARTSKQKCFELQAL--LEEERK-------AYRNQVEESTKQIQVL 531
++L K+++ Q +LA T K+ +L + LEE +K A ++EE L
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 532 QAQLQRLHIDTENLREEKD--SEITSTRDELLSARDEILLLHQA-AAKVASERDTDIASL 588
+ RL + ++L + D ++ S ++ D++L ++ +A+ A ERD A
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 589 QE------------------------ELKKVRAELERWRKAASEYEKEITSLQNSFQLRC 624
+E + K++RA++E + + K + L+ S +
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 625 QQCEDQQREEATRLQGELE-----KLRKEWNA----------LETECHSLKRENVLLSSE 669
QQ E + R + L+ EL+ KLR E N L+T + + LL +
Sbjct: 1539 QQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597
Query: 670 LQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQ 729
++ E EL + +KQ + +++ K+LE Q+ + + RD ++ L K + Q
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK--ARD--EVIKQLRKLQAQ 1653
Query: 730 AKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
KD Q+E E+ + E+ + + +E++ +S+ E+ Q + L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696
Score = 77.4 bits (189), Expect = 5e-14
Identities = 100/544 (18%), Positives = 229/544 (42%), Gaps = 38/544 (6%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQAC 227
LSQ L+E LE+ LQ+ L D Q + ++ + + + + ++
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 228 SKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECT 287
S E+ R E A +++ T SL R L+E +E + + L ++
Sbjct: 1464 SARYAEERDRAEAEAREKE------TKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 288 HLKEMNERTQEEL----RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEK---- 339
K+ + EL R L + ++++L D+L+ E + ++ QA K
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 340 KELQHKIDEMEEKEQELQAKIEALQAD-NDFTNERLTALQEHLLSKSGGDCTFIHQFIEC 398
++LQ + ++ EEK++ L ++ L+A+ D +R A+ K D + IE
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK--KKMEIDLKDLEAQIEA 1635
Query: 399 QKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEP 458
K + + + + +A+ D+ L ++ + ++ E+ L
Sbjct: 1636 ANK----------ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 459 LAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYR 518
A++ L+++L ++ A++ + R EL + + + K + + LE
Sbjct: 1686 EAEILQLQEELASSE---RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 519 NQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITST------RDELLSARDEILL-LH 571
++EE +++L + ++ + + L E +E ++ R +L E+ L
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 572 QAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ 631
+ V S+ I++L+ ++ ++ +LE+ K + K + + + Q ED++
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 632 REEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDL 691
R A + + ++EK L+ + + E ++ ++ ++EL ++ + + L+ ++
Sbjct: 1863 RH-ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Query: 692 SILQ 695
S L+
Sbjct: 1922 STLK 1925
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/342 (23%), Positives = 136/342 (39%), Gaps = 64/342 (18%)
Query: 134 EARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLL 193
EAR D I A K+ + E+ QL + L + + EQ+ L
Sbjct: 1663 EARASRDEIFAQSKESEKKLKS-----LEAEILQLQEELASSERARRHAEQERDELAD-- 1715
Query: 194 AITQEASDTSWQALIDEDRLL-SRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYET 252
IT AS S AL+DE R L +R+ + +L+ N + R LQ D N E
Sbjct: 1716 EITNSASGKS--ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 253 TAKES------------------LRRVLQEKIEVVR------------KLSEVERSLSNT 282
A+ S L+ LQE V+ K+ ++E L
Sbjct: 1774 AAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Query: 283 EDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKEL 342
E ++ RT+++L+E+ + D+ + A+ +E++ +K A K+L
Sbjct: 1834 AKERAAANKLVRRTEKKLKEI----------FMQVEDERRHADQYKEQM-EKANARMKQL 1882
Query: 343 QHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLS-----KSGGDCTFIHQFIE 397
+ +++E EE+ A LQ + D E L + + + GG +F
Sbjct: 1883 KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISF-SSSRS 1941
Query: 398 CQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKE 439
+++L +EG +LS ++ T +K SD ++T P E
Sbjct: 1942 GRRQLHLEG------ASLELS-DDDTESKTSDVNETQPPQSE 1976
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 112 bits (279), Expect = 2e-24
Identities = 155/636 (24%), Positives = 294/636 (46%), Gaps = 79/636 (12%)
Query: 164 ELFQLSQY--LQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLL------- 214
EL Q+S+ L EA + E T RLL + E + S ++E R
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME--NQSLTKTVEELRTTVDSVEGN 489
Query: 215 -SRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRV--LQEKIEVVRK 271
S++ M + Q SK + L E++ ++ N + +K+ ++ L++ IE +R+
Sbjct: 490 ASKILKMEKENQRLSKKV--EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELAN-KYNGAVNEIKDLSDKLKVAEGKQEE 330
SE R + E E HL + ++ + A + E K L + +K K +
Sbjct: 548 NSE--RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 331 IQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCT 390
I+ + + KKEL+H E E+ +EL+ ++ L+ +N+ +++T L+
Sbjct: 606 IEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKITNLK------------ 652
Query: 391 FIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQM 450
I C+K +E E ++L +EN+ K D L+ E S + ++Q+
Sbjct: 653 -----ITCEKIEALEQ------ENSELERENRKLKKTLDSFKNLTFQLE--SLEKENSQL 699
Query: 451 DEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL- 509
DE++L SL ++ AQ ++E K E++ +++L + EL + S +K L+
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 510 --LEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELLSARDE 566
L+ E + + +E S K+IQ L+++LQ L ++ + L++ ++ +I+S R E L ++
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 567 ILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQ 626
L + S+ + D L++E K++R + E E +I +L+ + ++
Sbjct: 819 SL------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 627 CEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
+E RL+ ELEK KE +KR + + + + +E +L + + ++ +
Sbjct: 873 I-GIYKESCVRLK-ELEKENKEL---------VKRATIDIKTLVTLRE-DLVSEKLKTQQ 920
Query: 687 LTSDLSILQMSRKELENQVGSLKEQHLRDSADL----KTLLSKAENQAKDVQKEYEKTQT 742
+ +DL L ELE ++G KE+ L D K L SK E+ K K E +
Sbjct: 921 MNNDLEKLT---HELE-KIGLNKERLLHDEQSTDDRYKLLESKLESTLK---KSLEIKEE 973
Query: 743 VLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
++ L+ + E + Q + ELK K N + L+++
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Score = 109 bits (272), Expect = 1e-23
Identities = 148/728 (20%), Positives = 313/728 (42%), Gaps = 122/728 (16%)
Query: 144 APLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTS 203
A + + + +V N +++ + +++ QE + E +L+ L+RL+ E S+T
Sbjct: 154 AAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDI--EPLLKNMALHLKRLIDERDEHSETI 211
Query: 204 WQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQ 263
+ + D L + C + + ++ ++++ AK +RR+ Q
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL------ADAKAKIRRLRQ 265
Query: 264 EKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEE-------------LRELA---NKY 307
E E +L + ++ L E E L++ N + LRE A +K
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKL 325
Query: 308 NGAVNEIKDLSDKLKVAEGKQEEIQQKGQA--EKKEL-----------QHKIDEMEEKEQ 354
V+ K+ ++ + + EE+++ Q E K + K+ E+E++
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENL 385
Query: 355 ELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEE 414
+L+AK+ ++ + D +++ L E ++ +E +K ++ L E
Sbjct: 386 QLKAKLHDMEMERDMDRKKIEELMEENMT------------LEMAQKQSMDESLHLGWEL 433
Query: 415 TKLSKENQ-TRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQ 473
++S+ ++ + A + ++ E +S +M+ Q L + + ++ D ++G
Sbjct: 434 EQISRTSELSEAPQKSLGHEVN---ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 474 SEI-EAKQEIQHLRK--ELIEAQELA-RTSKQKCFELQALLEEERKAYRNQVE----EST 525
S+I + ++E Q L K E++E + + + S Q C L L +E+ +E S
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 526 KQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDI 585
+QI++L+ + + L+ +LR+ S + E +LH++ + +S+ +
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQ---ISAEARVKDIEKENKILHESIKETSSK----L 603
Query: 586 ASLQEELKKVRAELERWRKA---ASEYEKEITSLQN----------SFQLRCQQCE--DQ 630
+ ++ E ++++ ELE +++ A E E E+ L+ + ++ C++ E +Q
Sbjct: 604 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 631 QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSE--------------------L 670
+ E R +L+K + L + SL++EN L E L
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTL------LS 724
Q + KEL + ++Q L L +L+ S K+ E S + + + KTL +
Sbjct: 724 QLENKELESEKEQ---LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 725 KAENQAKDVQKEYEKTQTVLSELKL---KFEMTEQEKQSITDEL-------KQCKNNLKL 774
+ E++ +D++ E + Q L ELK+ + E E+E +S+ E KQ + K
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 775 LREKGNNK 782
LR++ K
Sbjct: 841 LRQQAEIK 848
Score = 92.0 bits (227), Expect = 2e-18
Identities = 151/724 (20%), Positives = 285/724 (39%), Gaps = 130/724 (17%)
Query: 129 LPDGMEARLRSDVIHAPLPSPV--DKVAANTPSMYSQELFQLSQY---LQEALHREQMLE 183
L D AR+ D + A V DK+ + S Y + L + Y ++E Q+L
Sbjct: 299 LSDARSARMYRDELDALREKAVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 184 QKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIAL 243
+ L+ L T+ SD + + +L ++L M D RK++ L
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM---------EMERDMDRKKIEEL 408
Query: 244 QEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL-KEMNERTQEELRE 302
E+ E K+S+ E + + +L ++ R+ +E L E+NE T L +
Sbjct: 409 MEENMTLEMAQKQSM----DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 303 LANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEA 362
L + +++L + EG KI +ME++ Q L K+E
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNAS---------------KILKMEKENQRLSKKVEI 509
Query: 363 LQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQ 422
L+ N+ E+ + LSK + K+ + L K +E + + E Q
Sbjct: 510 LE--NEIVQEKQSLQNCQNLSK------------DLMKE---KAQLEKTIETLRENSERQ 552
Query: 423 TRAKESD---FSDTLSPSKEKSS--------DDTTDAQMDEQDLNEPLAKVSLLKDDLQG 471
+ E + + T+S +++S D + ++ + + E +K+S ++ + +
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 472 AQSEIE-----------AKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQ 520
+ E+E + E+ HL KE Q+ K C +++AL +E ++
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN-----SE 667
Query: 521 VEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASE 580
+E ++++ + L E+L +E + +E L R + L A+ K+A
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKEN----SQLDEENLELRRNVESLKCASMKMAQL 723
Query: 581 R--DTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRL 638
+ + ++ S +E+LKK L+ K E L Q R Q+ + ++ +L
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-RLQKTLENSNKKIQQL 782
Query: 639 QGELEKLRKEWNALETECHSLK----------RENVLLSSELQRQEKELHNSQKQSLELT 688
+ EL+ L E L+ LK +EN L E + EK+ +K++ L
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 689 SDLSI--------------LQMSRKELENQVGSLKEQHL--------------RDSADLK 720
I L+ K L ++G KE + R + D+K
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 721 TLLSKAEN------QAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKL 774
TL++ E+ + + + + EK L ++ L E ++QS D K ++ L+
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
Query: 775 LREK 778
+K
Sbjct: 963 TLKK 966
Score = 66.6 bits (161), Expect = 9e-11
Identities = 120/604 (19%), Positives = 242/604 (40%), Gaps = 112/604 (18%)
Query: 178 REQMLEQKLAT------LQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQ 231
RE ++ +KL T L++L ++ + L DE R +++ ++L++ K
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 232 TEDSLRKELIALQEDKHNYETTAKESLRRVLQ---EKIEVVRKLSEVERSLSNTEDECTH 288
E +++E IA E + T + LR+ L+ + E +++ + ER + ++
Sbjct: 968 LE--IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDE 348
+ +QE REL + D+L E +Q AEK+ L+ ++ +
Sbjct: 1026 DNKWERESQETTRELLK-----------VKDRLIEVERNNATLQ----AEKQALKTQLKQ 1070
Query: 349 MEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHL 408
+E + LQA+I ALQ E+ T LQ
Sbjct: 1071 LETQNNNLQAQILALQRQTVSLQEQNTTLQ------------------------------ 1100
Query: 409 TKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDD 468
+ KL EN T +S +S +AQ+ L + S L+++
Sbjct: 1101 ---TQNAKLQVENSTLNSQS------------TSLMNQNAQL--------LIQQSSLENE 1137
Query: 469 LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQI 528
+ S I+ +++++ L LI+ E +L+ L E + Y + + +
Sbjct: 1138 NE---SVIKEREDLKSLYDSLIKDHE----------KLELLHERQASEYESLISKH---- 1180
Query: 529 QVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASL 588
L++ + L ++ +L E++ +++ + + L +++L + Q + ++ +A+
Sbjct: 1181 GTLKSAHKNLEVEHRDL-EDRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHETVAA- 1237
Query: 589 QEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKE 648
E KK+ E +R S+ KE LQ + + + + E TRL+ E KL+++
Sbjct: 1238 --EYKKLCGENDRLNHTYSQLLKETEVLQTDHK-NLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Query: 649 WNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSL 708
+ L+ L + LLS E+E + Q L L E ++
Sbjct: 1295 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1354
Query: 709 KEQHLRDSADLKTLLSKAENQAKDVQKEYEK----------TQTVLSELKLKFEMTEQEK 758
+ Q++ +L+ K E + D K Y+ T + +K K ++ + +
Sbjct: 1355 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1414
Query: 759 QSIT 762
+S+T
Sbjct: 1415 KSLT 1418
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 111 bits (277), Expect = 3e-24
Identities = 156/675 (23%), Positives = 296/675 (43%), Gaps = 98/675 (14%)
Query: 172 LQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRL-LSRLEVMGNQLQACSKN 230
L E L E+ + +L +R L E +S + ID+ L L+++E + + KN
Sbjct: 926 LTERLEEEEEMNSELVAKKRNL----EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKN 981
Query: 231 QTED--SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTH 288
+E+ +L + + L ++K + + +++L LQ + + V L ++ L D+
Sbjct: 982 LSEEMTALEENISKLTKEKKSLQEAHQQTLDD-LQVEEDKVNGLIKINAKLEQQTDDLEG 1040
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID- 347
E ++ + +L K G + ++ L+ + + EE +K + E +LQ KID
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100
Query: 348 ------EMEEKEQELQAKIEALQAD---------------NDFTNERLTALQEHLLSKSG 386
+ ++K +ELQA+IE L+ + +D E L + E L SG
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE-LEEISERLEEASG 1159
Query: 387 GDCTFIH-------QFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKE 439
I +F + ++ L +A T K+ + A+ + D L K+
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 440 KSSDDTTDAQMDEQDLNEPLAKVSLLKDDL-------QGAQSEIEAKQEIQ-------HL 485
K + ++ +M+ D+ + +S K ++ + SEI+AK E Q ++
Sbjct: 1220 KLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM 1279
Query: 486 RKELIEAQ--ELARTSKQKCFELQAL------LEEERKAYRNQVEESTKQIQVLQAQLQR 537
+K ++ Q EL+ ++K + L L ++ + + Q+EE TK + LQ
Sbjct: 1280 QKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 538 LHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKK 594
D + LRE+ + E + EL A L +A ++VA R +TD EEL++
Sbjct: 1340 SRHDCDLLREQYEEE-QEAKAELQRA------LSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 595 VRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALET 654
+ +L + + A E + S +C E ++ RLQGE+E L ++ T
Sbjct: 1393 AKKKLAQRLQEAEENTETANS-------KCASLEKTKQ----RLQGEVEDLMRDLERSHT 1441
Query: 655 ECHSLKR-----ENVLL--SSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGS 707
C +L + + VL +L + EL +QK+S L+++L ++ + +E+ +Q+ +
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 708 LKEQHLRDSADLKTL----------LSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQE 757
L+ ++ ++ L L +AE K V++E Q L E++ E E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 758 KQSITDELKQCKNNL 772
+ EL Q K+ L
Sbjct: 1562 ILRVQLELSQVKSEL 1576
Score = 92.4 bits (228), Expect = 1e-18
Identities = 133/665 (20%), Positives = 277/665 (41%), Gaps = 71/665 (10%)
Query: 162 SQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMG 221
S + + + + +Q L Q+L L+R + +A + AL L
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351
Query: 222 NQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSN 281
+ Q +K + + +L K + + + YET A + + + K ++ ++L E E +
Sbjct: 1352 EEEQE-AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Query: 282 TEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK-----VAEGKQ--EEIQQK 334
+C L++ +R Q E+ +L + L K + +AE KQ +E Q +
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE 1470
Query: 335 GQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTF 391
+A +KE L ++ +M +E+ ++E L+ +N E ++ L E + +++G +
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI-AETGKNL-- 1527
Query: 392 IHQFIECQKKLIVE--GHLTKAVEETKLSKENQ------TRAKESDFSDTLSPSKEKSSD 443
Q E KKL+ + L A+EE + S E++ + + S L + +
Sbjct: 1528 --QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 444 DTTDAQMDEQDLNEPLAKVS-----------LLKDDLQGAQSEIEAKQEIQHLRKELIEA 492
+ + + Q E L V LK ++G +E+E ++ H +++ E
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI--QLGHSNRQMAET 1643
Query: 493 QELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---EEK 549
Q+ RT + + + Q L++ ++ E+ +Q+ +++ + L + E ++ E+
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSN----EDLKEQLAIVERRNGLLLEELEEMKVALEQT 1699
Query: 550 DSEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAA 606
+ + ELL A D + LLH + + + + DIA Q E V ++ R A
Sbjct: 1700 ERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAE---VENSIQESRNAE 1756
Query: 607 SEYEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL-- 659
+ +K IT E+ ++E+ T R++ LE+ K+ E L
Sbjct: 1757 EKAKKAITD-------AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Query: 660 ---KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDS 716
K++ L + ++ E EL QK+ E + KE+ Q E+ ++
Sbjct: 1810 KGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQA----EEDHKNI 1865
Query: 717 ADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLR 776
L+ L+ K + + K +++ E+ + + + + E + + ++ + LR
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
Query: 777 EKGNN 781
K +
Sbjct: 1926 AKSRD 1930
Score = 90.9 bits (224), Expect = 4e-18
Identities = 127/579 (21%), Positives = 249/579 (43%), Gaps = 76/579 (13%)
Query: 238 KELIALQED-KHNYETTAKESLRR---------VLQEKIEVVRKLSEVERSLSNTEDECT 287
KE+ ++ED + E A+ RR +LQEK ++ ++ +L + E+ C
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 288 HL-----------KEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQ 336
L KE+ ER +EE E+ ++ ++D LK E K +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEE-EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVE 969
Query: 337 AEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFI 396
EK ++K+ + E+ L+ I L + + L + L + ++ I
Sbjct: 970 KEKHATENKVKNLSEEMTALEENISKLTKE----KKSLQEAHQQTLDDLQVEEDKVNGLI 1025
Query: 397 ECQKKLIVE-GHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDL 455
+ KL + L ++E+ K + + RAK D L S+E D D Q E+ L
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD-LKMSQESIMDLENDKQQIEEKL 1084
Query: 456 NEPLAKVSLLK---DDLQGAQSEIEAK-QEIQHLRKELIEAQELARTSKQKCFELQALLE 511
+ ++S L+ DD Q + + K +E+Q +EL E E T L+A +E
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT-------LRAKIE 1137
Query: 512 EERKAYRNQVEESTKQIQ----VLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEI 567
++R ++EE +++++ AQ++ + +++++E R +L +E
Sbjct: 1138 KQRSDLARELEEISERLEEASGATSAQIE--------MNKKREAEFQKMRRDL----EEA 1185
Query: 568 LLLHQAAAKVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSL---------- 616
L H+A A ++ D +A L E++ ++ ++ K SE + EI +
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245
Query: 617 QNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE 676
+++ + C+ EDQ E ++ + E+ + + L + L+ +N LS ++ +E
Sbjct: 1246 KSNIERTCRTVEDQFSE----IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKE--QHLRDSADLKTLLSKAENQAK-DV 733
+ K LT L L+ +E ++ Q R DL + E +AK ++
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 734 QKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
Q+ K + +++ + K+E ++ T+EL++ K L
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQR---TEELEEAKKKL 1397
Score = 88.6 bits (218), Expect = 2e-17
Identities = 117/546 (21%), Positives = 243/546 (44%), Gaps = 66/546 (12%)
Query: 265 KIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDL------- 317
KI+ + K +E E+ ++ +++ KE R++ +EL K + E DL
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 318 SDKLKVAEGKQEEIQQKG---QAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERL 374
++ L AE + E + + +A+ KEL +++E EE EL AK L+ ++
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLE-------DKC 951
Query: 375 TALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
++L+ + D +E ++K E + EE +EN ++ + S L
Sbjct: 952 SSLKRDI-----DDLELTLTKVE-KEKHATENKVKNLSEEMTALEENISKLTKEKKS--L 1003
Query: 435 SPSKEKSSDDTTDAQMDEQDLNEPL---AKVSLLKDDLQGA-QSEIEAKQEIQHLRKELI 490
+ +++ DD Q++E +N + AK+ DDL+G+ + E + + +++ +++L
Sbjct: 1004 QEAHQQTLDDL---QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 491 EAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---- 546
++++ S LE +++ Q+EE K+ + +QLQ ID E +
Sbjct: 1061 GDLKMSQESIMD-------LENDKQ----QIEEKLKKKEFELSQLQA-KIDDEQVHSLQF 1108
Query: 547 EEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKK--------VRAE 598
++K E+ + +EL +EI H AK+ +R +D+A EE+ + A+
Sbjct: 1109 QKKIKELQARIEEL---EEEIEAEHTLRAKIEKQR-SDLARELEEISERLEEASGATSAQ 1164
Query: 599 LERWRKAASEYEKEITSLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETE 655
+E +K +E++K L+ + + +Q + L +++ L++ LE E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 656 CHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLR- 714
LK E ++S ++ K N ++ + S ++ ++ + L Q R
Sbjct: 1225 KSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARL 1284
Query: 715 --DSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+ +L + + E+ + K + L ELK + E + K ++ L+ +++
Sbjct: 1285 QTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDC 1344
Query: 773 KLLREK 778
LLRE+
Sbjct: 1345 DLLREQ 1350
Score = 80.1 bits (196), Expect = 8e-15
Identities = 124/569 (21%), Positives = 229/569 (40%), Gaps = 61/569 (10%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQ----------EASDTSWQALIDEDRLLSR 216
+L+Q LQEA + K A+L++ Q E S T+ L + R +
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 217 LEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVE 276
+ Q D + EL A Q++ + T L ++ EVV +L +
Sbjct: 1456 V--------LAEWKQKLDESQAELEAAQKESRSLST----ELFKMRNAYEEVVDQLETLR 1503
Query: 277 RSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQ 336
R N ++E + L E T + L+E E DL L+ EG E + K
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563
Query: 337 AEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFI 396
+ EL E++ K E +IE L+ ++ E L ++ + + +S D +
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEI-RSRNDA------L 1616
Query: 397 ECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLN 456
+KK+ EG L + E +L N+ A+ T+ + S DA +DL
Sbjct: 1617 RLKKKM--EGDLNEM--EIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 457 EPLAKVS----LLKDDLQGAQSEIEAKQEIQHL----------RKELIEAQELARTSKQK 502
E LA V LL ++L+ + +E + + L R +L+ +Q + + +K
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKK 1732
Query: 503 CFEL-----QALLEEERKAYRNQVEESTKQIQ--VLQAQLQRLHIDTENLREEKDSEITS 555
E QA +E + RN E++ K I + A+ + DT E +
Sbjct: 1733 KLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Query: 556 TRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITS 615
T +L DE Q A K ++ I L+ ++++ EL+ +K +E K
Sbjct: 1793 TVKDLQHRLDEA---EQLALKGGKKQ---IQKLENRVRELENELDVEQKRGAEALKGAHK 1846
Query: 616 LQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEK 675
+ + Q E+ + RLQ ++KL+ + + + + + + S +R +
Sbjct: 1847 YERKVKEMTYQAEEDHKN-ILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 676 ELHNSQKQSLELTSDLSILQMSRKELENQ 704
EL + +++ S ++ L+ +++ +Q
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 111 bits (277), Expect = 3e-24
Identities = 147/664 (22%), Positives = 290/664 (43%), Gaps = 89/664 (13%)
Query: 151 DKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDE 210
+++ AN + SQ ++ ++E +Q LE+ L++ L + Q +
Sbjct: 645 ERMRANLEELRSQH----NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEI 700
Query: 211 DRLLSRLEVMGNQLQACSKNQTED--SLRKELIALQEDKHNYETTAKESLRRVLQEKIEV 268
L +L M ++L + +++ + +L +EL+ ++D + +E + + + E+
Sbjct: 701 RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760
Query: 269 VRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQ 328
++ +S+ + E LKE + + LRE + A ++ L+ + +E Q
Sbjct: 761 TALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE---ATKNVEVLASRSNTSEQDQ 817
Query: 329 EEIQQKG---QAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKS 385
+ + Q E ++LQ + +E+E + +LQ +IE L+ D A + L K
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE--------AKAKETLKKY 869
Query: 386 GGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDT 445
G+ + ++ L+ K + + EN+ A + + S T K+
Sbjct: 870 EGEIR------QLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ------ 917
Query: 446 TDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAK-----QEIQHLRKELIEAQELARTSK 500
L+E L + S K+ L+ ++E+E + + I+ L+KE+ + E +RTS
Sbjct: 918 ---------LSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS- 967
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQI--QVLQAQLQRLHI----DTENLREEKDSEIT 554
ELQ L+E ++ R ++ E +Q+ + L+A+ RL D L EE+ +
Sbjct: 968 --TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 555 STRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAEL-ERWRKAASEYEKEI 613
+DE L+ R LL Q + E + + LK R+ L ++ S+ E E+
Sbjct: 1026 RAQDEALTKRQ---LLEQTLKDLEYELEA-----KSHLKDDRSRLVKQMEDKVSQLEMEL 1077
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQ 673
+N+ L ++ + RE+ +L+ EL + R LE + SL+R+N L S +
Sbjct: 1078 EEERNNSDLLSERI-SRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHL 1136
Query: 674 EKELHNSQKQSLELTSDLSI----------------LQMSRKELENQVGSLKEQ------ 711
E + S K+ L + + I LQ+S + LE +V L Q
Sbjct: 1137 EGS-YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 712 HLRDSADLKTLLSKA-ENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKN 770
L D D +L KA + Q ++ ++E ++ ++ +L+ + E + + +L K
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKK 1255
Query: 771 NLKL 774
+L+L
Sbjct: 1256 DLRL 1259
Score = 100 bits (248), Expect = 7e-21
Identities = 108/552 (19%), Positives = 247/552 (44%), Gaps = 75/552 (13%)
Query: 248 HNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKY 307
+N + ++ +L++K ++ +++E++R L ++KE ER + L EL +++
Sbjct: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 308 NGAVNEIKDLSDKLKVAEGK-QEEIQQKGQAEKKELQH--KIDEMEEKEQELQAKIEALQ 364
N V E L +L+ +EG+ ++ +++ Q + + QH +I +++++ E+ ++++ +
Sbjct: 659 NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAK 718
Query: 365 ADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTR 424
D E+ ++E L +K + Q LI K +E+ R
Sbjct: 719 RSED--REKGALIEELLQAKQ-----------DLQDLLI-----------AKEEQEDLLR 754
Query: 425 AKESDFSDTLSPSKEK--SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEI 482
+E + + KE+ S D D ++ D A++ L++ ++ A + E+
Sbjct: 755 KRERELTALKGALKEEVSSHDQEMDKLKEQYD-----AELQALRESVEEATKNV----EV 805
Query: 483 QHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDT 542
R E + + K LL+EE + + + EE +++ LQ Q++ L D
Sbjct: 806 LASRSNTSEQDQAGTEMRVK------LLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 543 ENLRE---EKDSEITSTRDELLSARDE--------------------ILLLHQAAAKVAS 579
+E + + EI + L+ AR E L K S
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 580 ERDTDIASLQEELKKVRAEL--ERWR--KAASEYEKEITSLQNSFQLRCQQCEDQQREEA 635
E+ + + +E+L++++ E+ ERW K + +KE+ + + + + ++Q E
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK 979
Query: 636 TRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQ 695
+ + EL +++++ E + + + E++ E+EL + Q+ E + +L+
Sbjct: 980 EKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLE 1039
Query: 696 MSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTE 755
+ K+LE ++ + + HL+D D L+ + E++ ++ E E+ + L + +
Sbjct: 1040 QTLKDLEYELEA--KSHLKD--DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
Query: 756 QEKQSITDELKQ 767
++ + + +EL Q
Sbjct: 1096 EQMEQLRNELLQ 1107
Score = 76.3 bits (186), Expect = 1e-13
Identities = 122/549 (22%), Positives = 226/549 (41%), Gaps = 106/549 (19%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLL-----AITQEAS-------------DTSW 204
+EL Q Q LQ+ L ++ E L +R L A+ +E S D
Sbjct: 730 EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789
Query: 205 QALIDE-DRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRV-- 261
QAL + + +EV+ ++ ++Q +R +L LQE+ + ++E RRV
Sbjct: 790 QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQ 847
Query: 262 LQEKIEVVR-KLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDK 320
LQ +IE ++ ++ + +L E E L+E ++E +E + NE++
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 321 LKVAEGKQEEIQQKGQAE---KKELQHKIDEMEEKEQELQAKIEALQ--------ADNDF 369
L +Q+++ +K + E K++L+ +EME + L IE LQ A
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESD 429
T E L E+ + E Q++L + + T + +++ R E +
Sbjct: 968 TLELQNQLDEYKEKNR-------RELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE 1020
Query: 430 FSDTLSPSKEKSSDDT-TDAQMDEQ---DLNEPLAKVSLLKDD-------LQGAQSEIE- 477
D +++ D+ T Q+ EQ DL L S LKDD ++ S++E
Sbjct: 1021 LRDY-----QRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 478 ------------------AKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERK---- 515
++++++ LR EL+ QE A +C ++ LE + K
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELL--QERAARQDLECDKIS--LERQNKDLKS 1131
Query: 516 -------AYRNQVEESTKQIQVLQAQLQ---------RLHIDTENLR-EEKDSEITSTRD 558
+YR+ E Q++ A+L+ R ++ N R E K E+ D
Sbjct: 1132 RIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVD 1191
Query: 559 E----LLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEIT 614
+ L +D++ L +A + E + +I L+ KK++ ELE + ++
Sbjct: 1192 DEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN 1251
Query: 615 SLQNSFQLR 623
S++ +L+
Sbjct: 1252 SMKKDLRLK 1260
Score = 73.9 bits (180), Expect = 5e-13
Identities = 80/367 (21%), Positives = 167/367 (45%), Gaps = 41/367 (11%)
Query: 440 KSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA-QSEIEAKQEIQHLRKEL-IEAQELAR 497
+ ++ ++ + +DL E +K+++ +LQ Q E++ +Q I+ R+ + +EL
Sbjct: 597 QGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS 656
Query: 498 TSKQKCFE---LQALLEEERKAYRNQVEESTK----------QIQVLQAQLQRLHIDTEN 544
+K E LQ LEE R +EE + +I+ LQ QL +H + ++
Sbjct: 657 QHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 545 LREEKDSEITSTRDELLSARDEI---LLLHQAAAKVASERDTDIASLQEELKK-VRAELE 600
+ +D E + +ELL A+ ++ L+ + + +R+ ++ +L+ LK+ V + +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 601 RWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLK 660
K +Y+ E+ +L+ S + + E T Q + E L+
Sbjct: 777 EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA--------GTEMRVKLLQ 828
Query: 661 RENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK 720
EN L + E+ + Q+Q +L D + + + K+ E ++ L+E + + K
Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
Query: 721 TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK---QCKNNLKLLRE 777
+A + + ++ E E Q LS+ T QE++ ++++LK + K L+ L+
Sbjct: 889 ----EAVSARRALENELEAAQGNLSQ-------TTQEQKQLSEKLKEESEQKEQLRRLKN 937
Query: 778 KGNNKPW 784
+ N+ W
Sbjct: 938 EMENERW 944
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 110 bits (275), Expect = 5e-24
Identities = 143/682 (20%), Positives = 300/682 (43%), Gaps = 96/682 (14%)
Query: 173 QEALHREQMLEQKL---ATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSK 229
QE LH +Q+ EQK A R+L++ ++ + Q L + +S+L++ Q +K
Sbjct: 595 QENLH-DQVQEQKAHLRAAQDRVLSLETSVNELNSQ-LNESKEKVSQLDI-----QIKAK 647
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL 289
+ S A + D N+ TA+ +L+ QE ++ +L +V L + ++ C+ L
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 290 KEMNERTQEELRELANKYNGAVNEIKDL-SDKLKVAEGKQEEIQQKGQAEK--------- 339
+ + +E+ L K +IK L +D L+V K++ +Q Q +
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 340 ----KELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEH--LLSKS----GGDC 389
K+L+ + + + +LQ K EAL++ ++LT +E +L + +
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALES----IKQKLTKQEEEKQILKQDFETLSQET 823
Query: 390 TFIHQFIECQ-KKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSK---EKSSDDT 445
H+ + + + + E K +E +++ + + K S SD+L SK EK +
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883
Query: 446 TDAQMD------------EQDLNEPLAKVSLLKDDLQGA-QSEIEAKQEIQHLRKELIEA 492
A +D + + L + LK L+ ++ + K E+ ++++LI+A
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
Query: 493 QELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSE 552
Q + ++++ +LQ + E +++ E+ KQI+ LQ +L+ + L + +
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSS----EQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 553 ITSTRDELLSARDEILLLHQAAAKVASE----------RDTDIASLQEELKKVRAEL--- 599
+T EL + +++I +L K R++++ + +++LK V +L
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 600 ------------------ERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGE 641
+ + A + E++ + Q RC+ +D Q+E++ + +
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 642 LEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKEL 701
+ + K E +C ++E L+ EL+ + E S K+ L +L + EL
Sbjct: 1120 VNEKSKLAEIEEIKCRQ-EKEITKLNEELKSHKLE---SIKEITNLKDAKQLLIQQKLEL 1175
Query: 702 ENQVGSLK---EQHLRDSADLKTLLSKAENQAKD--VQKEYEKTQTVLSELKLKFEMTEQ 756
+ + SLK EQ R+ LK + K E + K ++KE K + + E ++ + E+
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKE-AKLHSEIKEKEVGMKKHEE 1234
Query: 757 EKQSITDELKQCKNNLKLLREK 778
+ +T ++ NL ++++
Sbjct: 1235 NEAKLTMQITALNENLGTVKKE 1256
Score = 107 bits (266), Expect = 6e-23
Identities = 148/692 (21%), Positives = 317/692 (45%), Gaps = 123/692 (17%)
Query: 162 SQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALID---EDRLLSRLE 218
SQ L +Y ++ L EQ E+ +++L A + E + QAL D + +L + LE
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
Query: 219 VMGNQLQACSK------NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKL 272
+ +L + + T L+K+ AL+ K + T +E +++L++ E + +
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ--KLTKQEEEKQILKQDFETLSQE 822
Query: 273 SEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQ 332
++++ N + T + E+ ++ + E L + + +++ +SD LK ++ + E+
Sbjct: 823 TKIQHEELNNRIQTT-VTEL-QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 333 QKGQA-----EK--KELQHKID-EMEEKEQELQAKIEALQADNDFTNE---RLTALQEHL 381
QKG+A EK KEL+H++ +ME +E + ++L+ + + +++ L ++QE L
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 382 LSKSG-------------GDCTFIHQFIECQKKLI--VEGHLTKAVEETKLSKENQTRAK 426
+ G+ + Q E +KK I ++G L AV + K EN+ + +
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ-KTELENKLQQQ 999
Query: 427 ESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEA-KQEIQHL 485
+ + L+ KEK S + + ++ + L+ D G +SE+ A +Q+++ +
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQ-------LQSDFYGRESELLATRQDLKSV 1052
Query: 486 RKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENL 545
++L AQE +++ + L++E + A ++S K+ Q LQ + + L D +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKE 1111
Query: 546 REEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKA 605
+ K+ E+ + + +L + + ++ +I L EELK + E
Sbjct: 1112 KSLKEKELVNEKSKLAEIEE-----------IKCRQEKEITKLNEELKSHKLESI----- 1155
Query: 606 ASEYEKEITSLQNSFQLRCQQ--------------CEDQQREEAT---RLQGELEKLRKE 648
KEIT+L+++ QL QQ E ++R + +++ E E+L+KE
Sbjct: 1156 -----KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
Query: 649 WNALETECHSLKRENVL------------------LSSELQRQEKELHNSQ-------KQ 683
+ E + HS +E + L+ L +KE +SQ KQ
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
Query: 684 SLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTV 743
+ +L ++++L+ + + +++ +L E+ L+ +++ K + + ++Q++ + T
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE----KLQTKVLELQRKLDNTTAA 1326
Query: 744 LSE-------LKLKFEMTEQEKQSITDELKQC 768
+ E L++K K + +E++ C
Sbjct: 1327 VQELGRENQSLQIKHTQALNRKWAEDNEVQNC 1358
Score = 106 bits (264), Expect = 1e-22
Identities = 124/597 (20%), Positives = 254/597 (42%), Gaps = 81/597 (13%)
Query: 214 LSRLEVMGNQLQACSKNQTEDSLRKELIALQ-EDKHNYETTAKESLRRVLQEKI----EV 268
L +L+ N+L ++ TE+ L+KE + E+KHN E+ +K++++ L +K ++
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 269 VRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQ 328
+LS E SL E + E ++ +EEL E+ KY E K L + +
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ-------R 402
Query: 329 EEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERL-------------- 374
EE +Q G + E+ ++ E E++L L+ ++E+L
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 375 TALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
+ L+E L K HQ + TK + + + + T AK + + L
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDK-----------TKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 435 SPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQE 494
+ D Q E L + +SLL+ + + ++I+A + + +L QE
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL---QE 568
Query: 495 LARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLH---IDTENLREEKDS 551
T +++ +L L+ + ++++ E Q+Q +A L+ + E E +S
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 552 EITSTRDEL------LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKA 605
++ +++++ + A+ E LLL AAK A D ++ L+ + A
Sbjct: 629 QLNESKEKVSQLDIQIKAKTE-LLLSAEAAKTAQRAD------------LQNHLDTAQNA 675
Query: 606 ASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVL 665
+ ++E+ + + +D+Q E ++L+ L++ ++++ +LE + L+ +
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQ-EHCSQLESHLKEYKEKYLSLEQKTEELEGQ--- 731
Query: 666 LSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSK 725
+L+ E+ S++Q+L+ DL + +LE + L +Q L
Sbjct: 732 -IKKLEADSLEVKASKEQALQ---DLQQQRQLNTDLELRATELSKQ-----------LEM 776
Query: 726 AENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNK 782
+ + + +K L +K K E+EKQ + + + K+ E+ NN+
Sbjct: 777 EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Score = 106 bits (264), Expect = 1e-22
Identities = 151/676 (22%), Positives = 289/676 (42%), Gaps = 94/676 (13%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
+++Q + L E+ L + L+ ++ E Q + D LSRLE QL+
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE---EQLKE 471
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKI-EVVRKLSEVERSLSNTEDE 285
N TE + Q DK + +++L++ K+ E L +V R + + + +
Sbjct: 472 KVTNSTE-------LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 286 CTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHK 345
+L+ + ++++E + L E +DL K++ EG+ + Q Q + LQ +
Sbjct: 525 IQNLEALLQKSKENISLLEK-------EREDLYAKIQAGEGETAVLNQL-QEKNHTLQEQ 576
Query: 346 IDEMEEK-EQELQAKIEALQADNDFTNER---LTALQEHLLSKSGGDCTFIHQFIECQKK 401
+ ++ EK + + ++ +A + +D E+ L A Q+ +LS Q E ++K
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 402 LIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAK 461
+ KA E LS E A+ +D + L ++ D + L++ AK
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
Query: 462 V-----------SLLKD-------------DLQGAQSEIEA---------KQEIQHLR-- 486
+ S LK+ +L+G ++EA +Q +Q L+
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ 756
Query: 487 KELIEAQELARTSKQKCFELQAL--------LEEERKAYRNQVEESTKQI---QVLQAQL 535
++L EL T K E++ L+++ +A + ++ TKQ Q+L+
Sbjct: 757 RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF 816
Query: 536 QRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKV 595
+ L +T+ EE ++ I +T EL + E L + V + SL+ +
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 596 RAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETE 655
E ++ + A + EK L++ Q++ + +Q+E L+ LEK ++ + L+ E
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE----LKKSLEKEKEASHQLKLE 932
Query: 656 CHSLKRENVLLSSELQRQEKELH------NSQKQSLE--------LTSDLSILQMSRKEL 701
+S++ + + + L++ EKE N KQS E L +L I + + EL
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 702 ENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSI 761
EN++ +Q L +A L+ + + +Q YEK+Q +L+ F E E +
Sbjct: 993 ENKL----QQQLTQAAQ---ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 762 TDELKQCKNNLKLLRE 777
+LK + L L +E
Sbjct: 1046 RQDLKSVEEKLSLAQE 1061
Score = 97.4 bits (241), Expect = 5e-20
Identities = 140/646 (21%), Positives = 280/646 (43%), Gaps = 84/646 (13%)
Query: 162 SQELFQLSQYLQEALHREQMLEQ-KLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
S EL L Q L+EA ++Q K Q+ + E +D ++ DE+R L
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI--KSKYDEERSLR----- 186
Query: 221 GNQLQACSKNQTE--DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK-LSEVER 277
+A + T + L KE +Q+ K E L+R E + V++K L +V+
Sbjct: 187 ----EAAEQKVTRLTEELNKEATVIQDLK-------TELLQRPGIEDVAVLKKELVQVQT 235
Query: 278 SLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQA 337
+ N E + +E+ ++E ++L ++Y + I L +L A+G QE +
Sbjct: 236 LMDNMTLE---RERESEKLKDECKKLQSQYASSEATISQLRSEL--AKGPQEVAVYVQEL 290
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIE 397
+K L+ ++E+ +K Q L + L+ + D+T E +SK T + ++
Sbjct: 291 QK--LKSSVNELTQKNQTLTENL--LKKEQDYTKLE-EKHNEESVSKKNIQATLHQKDLD 345
Query: 398 CQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
CQ+ ++ L+ + ET L + + +++ + + +K ++ ++ + Q L
Sbjct: 346 CQQ---LQSRLSAS--ETSLHRIHVELSEKGE-------ATQKLKEELSEVETKYQHLKA 393
Query: 458 PLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAY 517
++ +++ + Q ++ + EI L +L+E + ++ E L+E+R+
Sbjct: 394 EFKQLQQQREEKE--QHGLQLQSEINQLHSKLLETE-------RQLGEAHGRLKEQRQLS 444
Query: 518 RNQVEESTKQIQVLQAQLQRLHIDTENLREE--KDSEITSTRDELLSARDEILLLHQAAA 575
++ + +Q+ LQ +L RL E L+E+ +E+ D+ E L Q+
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLE---EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Query: 576 KVASERDTDIASL-------QEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCE 628
E D+ + ++++ + A L++ ++ S EKE L Q +
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 629 --DQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
+Q +E+ LQ ++ +L ++ ++E H +EN L ++Q Q+ L +Q + L
Sbjct: 562 VLNQLQEKNHTLQEQVTQLTEKLKN-QSESHKQAQEN--LHDQVQEQKAHLRAAQDRVLS 618
Query: 687 LTSDLSILQMSRKELENQVGSLKEQ--------------HLRDSADLKTLLSKAENQAKD 732
L + ++ L E + +V L Q ADL+ L A+N +D
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 733 VQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
Q+E K T L ++ K + ++ + LK+ K L +K
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 110 bits (275), Expect = 5e-24
Identities = 150/667 (22%), Positives = 283/667 (42%), Gaps = 102/667 (15%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D +++L LQ + +D +
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD------L 1014
Query: 242 ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELR 301
++EDK N T AK L + ++ ++E SL + C L+ + + +L+
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQ----------QVDDLEGSLEQEKKLCMDLERAKRKLEGDLK 1064
Query: 302 ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK---ELQHKIDEMEEKEQELQA 358
N+ + L++KLK E + +Q K + E+ +LQ KI E++ + +EL+
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 359 KIEALQADNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGH-LTKA 411
+IEA +A ++ + L L L ++GG + IE KK E + +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS---AQIEMNKKREAEFQKMRRD 1181
Query: 412 VEETKLSKENQT---RAKESDFS-------DTLSPSKEKSSDDTTDAQMDEQDLNEPLAK 461
+EE+ L E R K +D D+L K+K + ++ +M+ DL +
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241
Query: 462 VSLLKDD-------LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQ------- 507
VS K + L+ SEI+ K+E Q + AQ+ ++ F Q
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 508 -ALLEEERKAYRNQVEESTKQIQ-------VLQAQLQRLHIDTENLREEKDSEITSTRDE 559
+ L ++A+ Q+EE +Q++ L LQ D + LRE+ + E + E
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE-QEAKAE 1360
Query: 560 LLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITS---- 615
L + + A+ ++ +TD EEL++ + +L + + A E+ + + S
Sbjct: 1361 LQRGMSKA---NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 616 -------LQNSFQ----------LRCQQCEDQQR----------EEATRLQGELEKLRKE 648
LQN + C + +QR ++ Q ELE +KE
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 649 WNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSL 708
+L TE +K L+ ++E N Q++ +LT ++ ELE +
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE----KV 1533
Query: 709 KEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQC 768
K+Q + ++L+T L +AE + + + + Q L+++K + + EK D+LK
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK-- 1591
Query: 769 KNNLKLL 775
+N+L+++
Sbjct: 1592 RNHLRVV 1598
Score = 97.4 bits (241), Expect = 5e-20
Identities = 113/530 (21%), Positives = 224/530 (42%), Gaps = 57/530 (10%)
Query: 280 SNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEK 339
+ TE E ++KE E+T+EEL + K K+L +K+ ++ ++Q + QAE
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKR-------KELEEKMVTLMQEKNDLQLQVQAEA 899
Query: 340 KEL---QHKIDEMEEKEQELQAKIEALQA---DNDFTNERLTALQEHLLSKSGGDCTFIH 393
L + + D++ + + +L+AKI+ + D + N LTA + L +C+ +
Sbjct: 900 DALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED----ECSELK 955
Query: 394 QFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSK----EKSSDDTTDAQ 449
+ I+ + + + K E K+ + A + L+ K E D Q
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 450 MDEQDLN---EPLAKVSLLKDDLQGA-QSEIEAKQEIQHLRKELIEAQELARTS------ 499
M+E +N + K+ DDL+G+ + E + +++ +++L +LA+ S
Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075
Query: 500 -KQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRD 558
KQ+ E E E + ++E+ LQ +++ L E L EE ++E S
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS--- 1132
Query: 559 ELLSARDEILLLHQAAAKVASERDTDIASLQEELKKV----RAELERWRKAASEYEKEIT 614
A K S+ ++ + E L++ A++E +K +E++K
Sbjct: 1133 ------------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 615 SLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQ 671
L+ S + + + L +++ L++ LE E LK E L+S ++
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME 1240
Query: 672 RQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLR---DSADLKTLLSKAEN 728
K N +K L LS ++ +E + + L Q R +S + L + +
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDA 1300
Query: 729 QAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ + + + ELK + E + K ++ L+ +++ LLRE+
Sbjct: 1301 MVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Score = 95.1 bits (235), Expect = 2e-19
Identities = 122/571 (21%), Positives = 254/571 (44%), Gaps = 73/571 (12%)
Query: 238 KELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQ 297
KE +A E K +E + ++QEK ++ ++ +L++ E+ C L + + +
Sbjct: 864 KEELAKTEAKRK---ELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLE 920
Query: 298 EELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQ 357
+++E+ + +EEI + A+K++L+ + E+++ +L+
Sbjct: 921 AKIKEVTERAE------------------DEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 358 AKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTK----AVE 413
+ ++ + T ++ L E + +G D T + +KK + E H +E
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEM---AGLDETIAK--LTKEKKALQEAHQQTLDDLQME 1017
Query: 414 ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDL--NEPLAKVSLL--KDDL 469
E K++ + + K D L S E+ D + ++ L + LA+ S + ++D
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 470 QGAQSEIEAKQ-EIQHLRKELIEAQELARTSKQKCFELQAL---LEEERKAYRNQVEEST 525
Q +++ K+ E+ +L+ ++ + Q LA ++K ELQA LEEE +A R ++
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 526 KQIQVLQAQLQRLHIDTE----------NLREEKDSEITSTRDELLSARDEILLLHQAAA 575
KQ L +L+ + E + +++++E R +L +E L H+A A
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL----EESTLQHEATA 1193
Query: 576 KVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSLQN----------SFQLRC 624
++ D +A L E++ ++ ++ K SE + EI L + +F+ C
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMC 1253
Query: 625 QQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQS 684
+ EDQ E T+ + E ++L E +A + H+ E+ S +L ++ + +
Sbjct: 1254 RTLEDQLSEIKTK-EEEQQRLINELSAQKARLHT---ESGEFSRQLDEKDAMVSQLSRGK 1309
Query: 685 LELTSDLSILQMSRKELENQVGSLKE--QHLRDSADLKTLLSKAENQAK-DVQKEYEKTQ 741
T + L+ +E +L Q R DL + E +AK ++Q+ K
Sbjct: 1310 QAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKAN 1369
Query: 742 TVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+ +++ + K+E ++ T+EL++ K L
Sbjct: 1370 SEVAQWRTKYETDAIQR---TEELEEAKKKL 1397
Score = 91.3 bits (225), Expect = 3e-18
Identities = 137/645 (21%), Positives = 266/645 (41%), Gaps = 55/645 (8%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQ-EASDTSWQALIDEDRLLSRLEVMGNQLQ 225
QL + ++E R + LE+++ + A + + SD S + +RL Q++
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1166
Query: 226 ACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
K + E +R++L +E +E TA ++ E+ ++ ++R E
Sbjct: 1167 MNKKREAEFQKMRRDL---EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEK 1223
Query: 285 ECTHLK-EMNE--RTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKE 341
E + LK E+N+ E + + + ++D ++K E +Q+ + + A+K
Sbjct: 1224 EKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR 1283
Query: 342 LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQ-- 399
L + E + E A + L +++ L+ L ++ T H +
Sbjct: 1284 LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD 1343
Query: 400 ----KKLIVEGHLTKAVEETKLSKEN----QTRAK-ESDF---SDTLSPSKEKSSDDTTD 447
++ E KA + +SK N Q R K E+D ++ L +K+K + D
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 448 AQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQH-----LRKELIEAQELARTSKQK 502
A+ + +N A + K LQ ++ E + L K+ ++ KQK
Sbjct: 1404 AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQK 1463
Query: 503 CFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRL-HIDTENLREEKD--SEITSTRDE 559
E QA LE +K R+ ST+ +V A + L H++T RE K+ EI+ ++
Sbjct: 1464 YEETQAELEASQKESRSL---STELFKVKNAYEESLDHLETLK-RENKNLQQEISDLTEQ 1519
Query: 560 LLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNS 619
+ I L KV + D + + LQ L++ A LE + E+ +++
Sbjct: 1520 IAEGGKHIHELE----KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSE 1575
Query: 620 FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLK---RENVLLSSELQRQEKE 676
+ + +D++ ++ R L + + L+ E S R + +L E +
Sbjct: 1576 IDRKIAE-KDEELDQLKR--NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632
Query: 677 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKE 736
L+++ +Q+ E +L Q K+ + + + +R DLK L+ E +A +Q E
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHL----DDAIRGQDDLKEQLAMVERRANLMQAE 1688
Query: 737 YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNN 781
E EL+ E TE+ ++ EL ++LL + +
Sbjct: 1689 VE-------ELRASLERTERGRKMAEQELLDASERVQLLHTQNTS 1726
Score = 91.3 bits (225), Expect = 3e-18
Identities = 144/676 (21%), Positives = 292/676 (43%), Gaps = 99/676 (14%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
+S++L + + + +Q Q++ L+R L +A T AL L
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
+ Q +K + + + K + + + YET A + + + K ++ ++L + E +
Sbjct: 1351 YEEEQE-AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C L++ +R Q E+ +L +N A+++ + DK+ +AE KQ EE Q
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV-LAEWKQKYEETQ 1468
Query: 333 QKGQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ +A +KE L ++ +++ +E +E L+ +N + ++ L E + GG
Sbjct: 1469 AELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAE--GGK- 1525
Query: 390 TFIHQFIECQKKLIVE-GHLTKAVEETKLSKE-------------NQTRA----KESDFS 431
IH+ + +K+L E L ++EE + S E NQ ++ K ++
Sbjct: 1526 -HIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKD 1584
Query: 432 DTLSPSKE------KSSDDTTDAQMD------------EQDLNEPLAKVS---------- 463
+ L K +S T DA++ E DLNE +++
Sbjct: 1585 EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL 1644
Query: 464 --------LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEE-- 513
+LKD I + + L+++L + A + + EL+A LE
Sbjct: 1645 RNLRNTQGILKDTQLHLDDAIRGQDD---LKEQLAMVERRANLMQAEVEELRASLERTER 1701
Query: 514 -RKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQ 572
RK ++ ++++++Q+L Q L N +++ +++I+ + E+ ++I+ +
Sbjct: 1702 GRKMAEQELLDASERVQLLHTQNTSLI----NTKKKLETDISQIQGEM----EDIVQEAR 1753
Query: 573 AAAKVASERDTDIASLQEELKKVR---AELERWRKAASEYEKEITSLQNSFQLRCQQCED 629
A + A + TD A + EELKK + A LER +K + K++ QLR + E
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL-------QLRLDEAEQ 1806
Query: 630 QQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTS 689
+ + +++KL LE+E S ++ NV L++ E+ + Q+ E
Sbjct: 1807 LALKGGKK---QIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Query: 690 DLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSEL-K 748
++ LQ +L+ +V + K Q L+K ++++ E+ S++ K
Sbjct: 1864 NILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNK 1923
Query: 749 LKFEMTEQEKQSITDE 764
L+ + E + I++E
Sbjct: 1924 LRVKSREVHTKVISEE 1939
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/252 (23%), Positives = 116/252 (46%), Gaps = 51/252 (20%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++E + ++A+++EE +K + EL + E E+++ +L +N QL+ Q
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905
Query: 626 ------------QCEDQQREEATRLQGELE---KLRKEWNALETECHSLKRENVLLSSEL 670
Q E + +E R + E E +L + LE EC LK++ L L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK-------TLL 723
+ EKE H ++ + LT +++ L + +L + +L+E H + DL+ TL
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLT 1025
Query: 724 ---SKAENQAKDVQKEYEKTQTVLSEL-----KLKFEM---------TEQEKQSITDELK 766
+K E Q D++ E+ + + +L KL+ ++ TE +KQ + ++LK
Sbjct: 1026 KAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLK 1085
Query: 767 QCKNNLKLLREK 778
+ + + L+ K
Sbjct: 1086 KKEFEMSNLQGK 1097
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 110 bits (274), Expect = 7e-24
Identities = 128/633 (20%), Positives = 278/633 (43%), Gaps = 56/633 (8%)
Query: 172 LQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQ 231
L+E+ + LE+KL +++ QE D +A+ ++ LS L+ + +Q N+
Sbjct: 994 LKESAEFQTQLEKKLMEVEKE---KQELQDDKRRAIESMEQQLSELKKTLSSVQ----NE 1046
Query: 232 TEDSLRKELIAL---QEDKHNYETTAKESLR----------------RVLQEKIEVVRKL 272
+++L++ AL Q+ + + + AK ++ LQ E V K+
Sbjct: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
Query: 273 SEVERSLSNTEDEC-THLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
+ V + L T + + L E +E R L ++ + V +DL + ++ + E++
Sbjct: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
Query: 332 QQKGQAEKKE-----LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSG 386
K A KE L + E + ++++ + ++ + + R Q L
Sbjct: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLR--- 1223
Query: 387 GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDF---SDTLSPSKEKSSD 443
Q +E ++ + E + E K+ +T A+ + ++T++ E +
Sbjct: 1224 -----YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM 1278
Query: 444 DTTDAQMDEQDLNEPLAKVSLLKDD---LQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + EQDL + AKV L+ D LQ A +E+ K + K+L+E +++ R
Sbjct: 1279 LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKA 1337
Query: 501 QKCFELQALLEEERKAYRNQVEES---TKQIQVLQAQLQRLHIDTENLREEKDSEITSTR 557
+ + + + + YR + E TK+IQ L ++ RL + ++ +T+ +
Sbjct: 1338 RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR----SNASLTNNQ 1393
Query: 558 DELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQ 617
+ + S ++++ + + + D I +QE++K + + R+ ++YE E+ + Q
Sbjct: 1394 NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE-ELKAQQ 1452
Query: 618 NSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKEL 677
+ Q +E+ +Q E+++L++ N ET+ SL+ + L L +E E
Sbjct: 1453 DKVMETSAQSSGDHQEQHVSVQ-EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 678 HNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEY 737
N Q+Q+++L S+LS L+ ++ Q L++Q + + A+++ +
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK 1571
Query: 738 EKTQTVLSELKLKFEMTEQEKQSITDELKQCKN 770
++ ELK + +Q+K + + K+
Sbjct: 1572 DQLTKENEELKQRNGALDQQKDELDVRITALKS 1604
Score = 102 bits (255), Expect = 1e-21
Identities = 125/586 (21%), Positives = 258/586 (44%), Gaps = 70/586 (11%)
Query: 233 EDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEM 292
E+SL KE +E + N E KES Q ++E +KL EVE+ +D+ +
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAE--FQTQLE--KKLMEVEKEKQELQDD---KRRA 1025
Query: 293 NERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEK 352
E +++L EL + NE+++ + A +++ ++ Q + K ++ E +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERE 1085
Query: 353 EQELQAKIEALQADNDFTNERLTALQ-----------------------EHLLSKSGGDC 389
A +EALQA + ++ + Q E +L C
Sbjct: 1086 LMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKC 1145
Query: 390 TFIHQFIECQKKLI---VEGHLTKAVEETK----------LSKENQTRAKESDFSDTLSP 436
+ +E Q +L+ +E K V K LS+E +++ + + +
Sbjct: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR 1205
Query: 437 SKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQE-IQHLRKELIEAQEL 495
KE + AQ++ + +V LL+ +LQ Q + A++E +Q K + + +EL
Sbjct: 1206 EKEIAETRFEVAQVESLRYRQ---RVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL 1262
Query: 496 ARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITS 555
+ + E ++ E K R + E + +Q +QA++++L +D L +E ++E+ S
Sbjct: 1263 MKKT-----ETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL-QEANAEL-S 1315
Query: 556 TRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITS 615
+ +L A ++L + K R+ + S Q++ + E +RK SE E
Sbjct: 1316 EKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQKD-----PDTEEYRKLLSEKEVHTKR 1367
Query: 616 LQNSFQLRCQQCEDQQREEA--TRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQ 673
+Q + + + R A T Q ++ L+++ N + TE +++++ ++Q +
Sbjct: 1368 IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK 1427
Query: 674 EKELHNSQKQSLELTSDLSILQMSR-KELENQV---GSLKEQHL--RDSADLKTLLSKAE 727
K + +K + L+ + K +E G +EQH+ ++ +LK L++AE
Sbjct: 1428 VKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAE 1487
Query: 728 NQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
++K ++ + E Q LSE + + +++ + EL + + +L+
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ 1533
Score = 73.2 bits (178), Expect = 9e-13
Identities = 118/593 (19%), Positives = 248/593 (41%), Gaps = 69/593 (11%)
Query: 212 RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRK 271
++L R E+ N+L +N+ E L + + K +E ES Q+ E+ ++
Sbjct: 7 QVLERTEL--NKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE----QQYFEIEKR 60
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
LS + L N EC L+ E+ +L+ L K + +L++A+ + I
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEK-----------NKELEIAQDRNIAI 109
Query: 332 QQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERL---------TALQEHLL 382
Q + K+EL+ + ++ + L ++E L D NE+L L+ L
Sbjct: 110 QSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL 169
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHL-------TKAVEETKLSKEN-----QTRAKESDF 430
S + + +E +K+L+ + TK E L +E + + +
Sbjct: 170 QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENK 229
Query: 431 SDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQ----SEIEAKQEIQHLR 486
+ +S +E+ + T + ++ + + L K+ K+ + +E+ A ++ +L
Sbjct: 230 KEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLY 289
Query: 487 KELIEAQELARTSKQKCF-ELQALLEEERKAYRN------QVEESTKQIQVLQAQLQRLH 539
K + E + EL LL+E +A + +VE+S Q++ + L+++
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME--KEMLEKIG 347
Query: 540 IDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVA---------SERDTDIASLQE 590
+ L D + R + + +E+ + AA VA +E Q+
Sbjct: 348 RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 591 ELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWN 650
+L + E +R K E KE+ + + + ++ E Q+ A+ L +LE+ KE
Sbjct: 408 QLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVAS-LSVKLEQAMKEIQ 466
Query: 651 ALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELE-NQVGSLK 709
L+ + +++ +L + +R E ++ +L+ + +L M +E N V +
Sbjct: 467 RLQEDTDKANKQSSVLERDNRRMEIQVK-------DLSQQIRVLLMELEEARGNHVIRDE 519
Query: 710 EQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSIT 762
E D + ++S+ +++++ ++ Q +L L+ E E+E+Q T
Sbjct: 520 EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETT 572
Score = 69.7 bits (169), Expect = 1e-11
Identities = 142/705 (20%), Positives = 287/705 (40%), Gaps = 112/705 (15%)
Query: 170 QYLQEALHREQMLEQKLATLQRLLAITQEA----SDTSWQALIDEDRLLSRLEVMGNQLQ 225
Q +E L + LE++L LL+ T+ S+ A+ ++++ G +L
Sbjct: 337 QMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
Query: 226 ACSKN--QTEDSLRKELIALQE-----DKHNYETTAKESLRRVLQEKIEVVRK-LSEVER 277
+T+D L E + + D+ E AK + + +E+ E +K ++ +
Sbjct: 397 ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
Query: 278 SLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKV-------AEG---- 326
L E L+E ++ ++ L ++KDLS +++V A G
Sbjct: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVI 516
Query: 327 KQEEIQQKGQAEKKEL--QH-----KIDEMEEKEQELQAKIEAL-----QADNDFTNERL 374
+ EE+ + E+ QH I+E++++ Q L + L + + + T+ ++
Sbjct: 517 RDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKI 576
Query: 375 TALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
T LQ L S T + Q + ++ H + V+ + + + R S +
Sbjct: 577 TELQLKLESA----LTELEQLRKSRQ------HQMQLVDSI-VRQRDMYRILLSQTTGVA 625
Query: 435 SPSKEKSSDDTTDAQMDE-----QDLNEPLAKVSLLKDDLQGAQSEIEAKQEI-QHLRKE 488
P S DD + A + Q ++ P + + A++ ++ QEI ++ +KE
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
Query: 489 LIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQ--RLHIDTENLR 546
E +++ +K E L + Q++ ++K+ ++LQ ++ R I + + R
Sbjct: 686 KAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER 745
Query: 547 EEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAA 606
+K + T ++++++ + L VA R ++ +E LK L + R++
Sbjct: 746 NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL 805
Query: 607 SEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETEC-------HSL 659
++ L + Q E + E RL ++EKL E + L+ + H+L
Sbjct: 806 LAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTL 865
Query: 660 KRENVLLSSELQRQ---EKELH--------NSQKQSLELTSDLSILQM------------ 696
R + + +RQ E LH N+QK+ L LS +++
Sbjct: 866 TRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
Query: 697 ---SRKE-----------LENQVGSLKEQHLRDSADLK------TLLSKAENQAKDVQKE 736
S KE E QV LKE+ +++++ T L ++ N+ K V +E
Sbjct: 926 GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
Query: 737 YEKTQTV--------LSELKLKFEMTEQEKQSITDELKQCKNNLK 773
K V ++L+ K E+EKQ + D+ ++ +++
Sbjct: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME 1030
Score = 66.2 bits (160), Expect = 1e-10
Identities = 152/725 (20%), Positives = 299/725 (41%), Gaps = 150/725 (20%)
Query: 136 RLRSDVIHAPLPSPVDKVAANTPSMYSQ-ELFQLSQYLQEALHREQMLEQKLATLQRLLA 194
+L + I+ L V +V A P + Q E ++ +Q +L + LEQ + +QRL
Sbjct: 413 KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK--LEQAMKEIQRLQE 470
Query: 195 ITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTA 254
T +A+ S ++++ D R+E+ L +R L+ L+E + N+
Sbjct: 471 DTDKANKQS--SVLERDN--RRMEIQVKDLS--------QQIRVLLMELEEARGNHVIRD 518
Query: 255 KESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEI 314
+E + EV+ S+ S N E+ L++ N+R LREL
Sbjct: 519 EEVSSADISSSSEVI---SQHLVSYRNIEE----LQQQNQRLLVALRELG---------- 561
Query: 315 KDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDE-MEEKEQELQAKIEALQADNDFTNER 373
E ++ E Q+ ++ ELQ K++ + E EQ +++ +Q + +R
Sbjct: 562 ----------ETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR 611
Query: 374 LTALQEHLLSKSGGDCTFIH----------------------------------QFIECQ 399
+ LLS++ G +H + IE +
Sbjct: 612 --DMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK 669
Query: 400 KKL-----IVEGHLTKAVEETKLSKENQTRAKES---------------DFS----DTLS 435
L I E + + E K+ E + +E DF+ + L
Sbjct: 670 AALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
Query: 436 PSKEKSSDDTTDAQMDEQDLNEPLAK----VSLLKDDLQGAQSEI---EAKQEIQHLRKE 488
+ E + T Q L K ++ + DL+GA ++ E + E KE
Sbjct: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE 789
Query: 489 LIEAQELARTSKQKCFELQALLEEER---------KAYRNQVEES-TKQIQVLQAQLQRL 538
+++ E+ R S+Q+ ++LL E+R + + +E S T+ Q L +Q+++L
Sbjct: 790 MLKLSEV-RLSQQR----ESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
Query: 539 HIDTENLREEKDSEI----TSTRD---ELLSARDEI---LLLHQAAAKVASERDTDIASL 588
+ +L+++ ++E+ T TR+ +LL + ++ LH ++ +IA+L
Sbjct: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
Query: 589 QEELKKVRAEL-----ERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELE 643
++ L + ++ +R K ++++ L + QLR Q E+Q + RL+
Sbjct: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS--QLR--QTEEQVNDLKERLKTSTS 960
Query: 644 KLRKEWNALETECH-SLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELE 702
+ +++ A+ T SL +E + + E L S + +L L ++ ++EL+
Sbjct: 961 NV-EQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
Query: 703 NQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLS-ELKLKFEMTEQEKQSI 761
+ E + ++LK LS +N +VQ+ ++ T LS E + + + EQ K ++
Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAV 1076
Query: 762 TDELK 766
+ K
Sbjct: 1077 EAQNK 1081
Score = 44.3 bits (103), Expect = 5e-04
Identities = 49/203 (24%), Positives = 89/203 (43%), Gaps = 35/203 (17%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGN 222
QE+ +L + L +A + + LE ++ LQ + LS E
Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQ---------------------KTLSEKETEAR 1512
Query: 223 QLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNT 282
LQ + L+ EL L++D + TT +E LR+ + EK E RK ++
Sbjct: 1513 NLQ-----EQTVQLQSELSRLRQDLQD-RTTQEEQLRQQITEKEEKTRK------AIVAA 1560
Query: 283 EDECTHLKEMNERTQEELRELANKYNGAVNEIKD-LSDKLKVAEGKQEEIQQKGQAEKKE 341
+ + HL + ++ +E EL + NGA+++ KD L ++ + + E + + E +E
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQR-NGALDQQKDELDVRITALKSQYEGRISRLERELRE 1619
Query: 342 LQHKIDEMEEKEQELQAKIEALQ 364
Q + E ++ QE K+ Q
Sbjct: 1620 HQERHLEQRDEPQEPSNKVPEQQ 1642
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 108 bits (269), Expect = 3e-23
Identities = 139/598 (23%), Positives = 267/598 (44%), Gaps = 91/598 (15%)
Query: 252 TTAKESLRRVLQEKIEVVRKLSE----VERSLSNTEDECTHLKEMNER----TQEELREL 303
T E L+R L E+++ +KL +ER L +EC+ L+E+ ER Q+ +EL
Sbjct: 365 TRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKEL 424
Query: 304 ANK----------YNGAVNEIKDLSDKLKVAEGKQ--EEIQQKGQAEKKELQHKI----- 346
N +G ++ +L +KLK +G + +E+ K E +EL ++
Sbjct: 425 QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ 484
Query: 347 ---DEMEEKEQELQAKIEALQADNDFTNERLTALQEHL------LSKSGGDCTFIHQFIE 397
+++ +E+EL A AL+ + ++ + +++ L +S D T H +E
Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544
Query: 398 CQKK---LIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQD 454
+++ +V G L + +EET +T +S F + + +M++++
Sbjct: 545 AERQKMSALVRG-LQRELEET----SEETGHWQSMFQKN-KEDLRATKQELLQLRMEKEE 598
Query: 455 LNEPLA-KVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEE 513
+ E L K+ +L+ +L+ A++ ++++ L+KEL+ QE + ELQA + +
Sbjct: 599 MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK-------ELQAERQSQ 651
Query: 514 RKAYRNQVEESTKQIQVLQAQLQR-LHIDTENLREEK-------DSEITSTRDELLSARD 565
A R++ E KQ+ VL+ + R ++ +NL+ +K D E S + A
Sbjct: 652 EVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEA 711
Query: 566 EILLLHQAAAKVA---SERDTD-----IASLQEELKKVRAELERWRKAASEYEKEITSLQ 617
+L +AA + ++ + D I L+++LK+ R ++ + ++ L+
Sbjct: 712 TVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLE 771
Query: 618 NSFQLRCQQCEDQQREEAT------RLQGELEKLRKEWNALETECHSLKR--ENVLLSSE 669
Q + Q EE + L+ LE+ ++ L E +L R E E
Sbjct: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
Query: 670 LQRQEKELHNSQKQSLELTSDLSILQMSR---------KELENQVGSLKEQHLRDSADLK 720
+ R+ K QK+ L+ T D ++ + ++L+ Q+ KE+ R+ AD
Sbjct: 832 VLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVAD-- 889
Query: 721 TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
A+ QAKD E EKT LS L+ + + Q Q+ E + + +LL ++
Sbjct: 890 -----AQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQR 942
Score = 103 bits (257), Expect = 6e-22
Identities = 159/694 (22%), Positives = 306/694 (44%), Gaps = 137/694 (19%)
Query: 151 DKVAANTPSMYSQELFQLSQYLQEALHREQMLE---QKLATLQRLLAITQEASDTSWQAL 207
D+ + Y ++ QL + +Q+A +LE QK++ L R + +E +TS
Sbjct: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVR--GLQRELEETS---- 565
Query: 208 IDEDRLLSRLEVMGNQLQACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKI 266
E G+ KN+ + + ++EL+ L+ +K E + L EKI
Sbjct: 566 ----------EETGHWQSMFQKNKEDLRATKQELLQLRMEK--------EEMEEELGEKI 607
Query: 267 EVVRKLSEVERSLSNTEDECTHLKEMNERTQEELREL-ANKYNGAV------NEIKDLSD 319
EV+++ E R+ + + LK+ RTQEEL+EL A + + V E++
Sbjct: 608 EVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLA 667
Query: 320 KLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQE 379
L+V + E++++ +K LQ + EE + AK+ A +A+ +R A++
Sbjct: 668 VLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK---AKMVA-EAEATVLGQRRAAVET 723
Query: 380 HLLSKSGGDCTFIHQFIECQKKL-----IVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
L + F + + +++L +V+G +AVE K + A++ + L
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGG--EAVEARLRDKLQRLEAEKQQLEEAL 781
Query: 435 SPSKEK-----SSDDTTDAQMDE------------QDLNEPLAKVSLLKDDLQGAQSEIE 477
+ S+E+ ++ +A+++E Q LN L + ++ L+ ++E+E
Sbjct: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841
Query: 478 AKQE-----IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQ----- 527
++ + L KEL +++ SKQ +LQA LE+ ++ R +V ++ +Q
Sbjct: 842 EQKRLLDRTVDRLNKEL---EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
Query: 528 ---------IQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVA 578
+ LQ ++QRL + + E+D T+ D+ L A+ L +A K
Sbjct: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERD---TARLDKELLAQRLQGLEQEAENKKR 955
Query: 579 SERDT--DIASLQEELKKVRAELE--------------RWRKAASEYEKEITSLQNSFQ- 621
S+ D + L+E++ ++ EL+ R R + E+ +++ Q
Sbjct: 956 SQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQD 1015
Query: 622 LRCQQC--EDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
L C + E Q ++ TRL E +K +L L+ +N LL LQ +E+E
Sbjct: 1016 LECDKISLERQNKDLKTRLASS-EGFQKPSASLS----QLESQNQLLQERLQAEERE--- 1067
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSL------KEQHLRDSADLKTLLSKA-ENQAKD 732
++LQ + ++LE +V L + QH+ D D +L KA + Q +
Sbjct: 1068 -----------KTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDE 1116
Query: 733 VQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK 766
++E E+ L L+ K + +E+ + ++L+
Sbjct: 1117 AEEEIER----LDGLRKKAQREVEEQHEVNEQLQ 1146
Score = 97.8 bits (242), Expect = 3e-20
Identities = 105/463 (22%), Positives = 209/463 (45%), Gaps = 33/463 (7%)
Query: 314 IKDLSDKLKVAEGKQEEIQQKGQAEKK--ELQHKIDEMEEKEQELQAKIEALQADNDFTN 371
++ + + V+ G + + +G+ +K ELQ K+DE +K Q+L+ L+ +
Sbjct: 341 LEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKT 400
Query: 372 ERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH-LTKAVEETKLSKENQTR------ 424
E + LQE LL + G+ ++ ++ K+L+ +G L +E + +N+ +
Sbjct: 401 EECSRLQE-LLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPE 459
Query: 425 -AKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQ 483
AKE D L ++E + Q E+ L +++ LK L+ + QE++
Sbjct: 460 PAKEVLLKDLLE-TRELLEEVLEGKQRVEEQLRLRERELTALKGALK--EEVASRDQEVE 516
Query: 484 HLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTE 543
H+R++ E R S Q + A+LE ER ++ + ++ LQ +L+ +T
Sbjct: 517 HVRQQYQRDTEQLRRSMQDATQDHAVLEAER-------QKMSALVRGLQRELEETSEETG 569
Query: 544 NLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWR 603
+ + S +++L + + E+L L ++ E I LQ EL++ RA R
Sbjct: 570 HWQ----SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625
Query: 604 KAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQG-ELEKLRKEWNALETECHSLKRE 662
+ +KE+ L+ +L+ Q E Q +E A R + ELEK L+ +
Sbjct: 626 Q-VEVLKKEL--LRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ 682
Query: 663 NVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTL 722
N+ L LQ+ ++ + K + ++ ++L R +E + +E ++ + +
Sbjct: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE----ENDEFRRR 738
Query: 723 LSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDEL 765
+ E Q K+ + + + V + L+ K + E EKQ + + L
Sbjct: 739 ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
Score = 84.7 bits (208), Expect = 3e-16
Identities = 150/691 (21%), Positives = 286/691 (41%), Gaps = 126/691 (18%)
Query: 179 EQMLEQKL---ATLQRLLAITQEASDTSWQALIDEDRLLSR-------LEVMGNQLQACS 228
E+ LE+K + LQ LL + + S + L + RLL + LE +LQ
Sbjct: 393 ERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKL 452
Query: 229 KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS-------- 280
K+ KE++ K ET +E L VL+ K V +L ER L+
Sbjct: 453 KHVQGPEPAKEVLL----KDLLET--RELLEEVLEGKQRVEEQLRLRERELTALKGALKE 506
Query: 281 ---NTEDECTHLKEMNERTQEELR------------------ELANKYNGAVNEIKDLSD 319
+ + E H+++ +R E+LR +++ G E+++ S+
Sbjct: 507 EVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSE 566
Query: 320 KLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQE 379
+ + ++ ++ +A K+EL E EE E+EL KIE LQ + +
Sbjct: 567 ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA------- 619
Query: 380 HLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKE 439
S GD Q +K+L+ K ++ + S+E R ++ + L+ +
Sbjct: 620 -----SAGDT---RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRV 671
Query: 440 KSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTS 499
++ +++EQ+L L +D + +++++ A+ E L + + R +
Sbjct: 672 EAD---RGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRET 728
Query: 500 KQKCFELQAL---LEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLRE------EKD 550
+++ E + LE++ K R V+ L+ +LQRL + + L E E++
Sbjct: 729 QEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEE 788
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEE------LKKVRAELERWRK 604
+ + + L + +E + A++ E+ T +L+EE L++ +AELE ++
Sbjct: 789 GSLAAAKRALEARLEEA---QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 845
Query: 605 ----AASEYEKEITSLQNSFQLRCQQCEDQ--------QREEA----------------- 635
KE+ + + QQ + Q +RE A
Sbjct: 846 LLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTS 905
Query: 636 ---TRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS 692
+RLQ E+++LR+ A + E + + + LL+ LQ E+E N ++ + L
Sbjct: 906 GGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL- 964
Query: 693 ILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFE 752
K LE +V L E L + + LL+ N+ +D + ++ +T L + + +
Sbjct: 965 ------KGLEEKVSRL-ETELDEEKNTVELLTDRVNRGRD---QVDQLRTELMQERSARQ 1014
Query: 753 MTEQEKQSITDELKQCKNNLKLLREKGNNKP 783
E +K S+ + K K +L +G KP
Sbjct: 1015 DLECDKISLERQNKDLKT--RLASSEGFQKP 1043
Score = 64.7 bits (156), Expect = 3e-10
Identities = 94/427 (22%), Positives = 184/427 (43%), Gaps = 38/427 (8%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSR-LEVMG 221
Q L Q L+EAL+ Q E LA +R L E + L E + L+R LE G
Sbjct: 768 QRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827
Query: 222 NQLQACSKNQTEDSLRKELIALQEDKHNYETT-----AKESLRRVLQEKIEVVRKLSEVE 276
Q + + + E +K L+ D+ N E +K++L++ LQ ++E ++ +
Sbjct: 828 KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQ-LQAQLEDYKE--KAR 884
Query: 277 RSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQ 336
R +++ + + E+T L L ++ ++ + A +E + Q+ Q
Sbjct: 885 REVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQ 944
Query: 337 AEKKELQHKIDEMEEKEQELQA---KIEALQADNDFTNERLTALQEHLLSKSGGDCTFIH 393
++E ++K +++ ++L+ K+ L+ + D + L + + G D
Sbjct: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV--NRGRD----- 997
Query: 394 QFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSK--EKSSDDTTDAQMD 451
Q + + +L+ E + +E K+S E Q + D L+ S+ +K S + +
Sbjct: 998 QVDQLRTELMQERSARQDLECDKISLERQNK----DLKTRLASSEGFQKPSASLSQLESQ 1053
Query: 452 EQDLNEPLAKVSLLKDDLQGAQSEIEAK---------QEIQHLRKELIEAQELARTSKQK 502
Q L E L K LQ ++E K E QH+ + + + K++
Sbjct: 1054 NQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ 1113
Query: 503 CFELQALLEEE---RKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDE 559
E + +E RK + +VEE + + LQA+++ L D+ +E ++ ++E
Sbjct: 1114 VDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE-SALKNE 1172
Query: 560 LLSARDE 566
LS+ +E
Sbjct: 1173 GLSSDEE 1179
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/235 (22%), Positives = 99/235 (42%), Gaps = 14/235 (5%)
Query: 552 EITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEK 611
E+T +EL DE + Q + + EE +++ LER + A + K
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
Query: 612 EITSLQNSFQLRCQQCEDQQREEATR---LQGELEKLRKEWNALETECHSLKRENVLLSS 668
E LQN +L Q ED + T+ LQ +L+ ++ A E L LL
Sbjct: 423 E---LQNMKRL-LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEE 478
Query: 669 ELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAEN 728
L+ +++ + + ELT+ L+ + +V +++Q+ RD+ L+ + A
Sbjct: 479 VLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQ 538
Query: 729 QAKDVQKEYEKTQTVLSELKLKFEMTEQEK-------QSITDELKQCKNNLKLLR 776
++ E +K ++ L+ + E T +E Q ++L+ K L LR
Sbjct: 539 DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR 593
Score = 40.4 bits (93), Expect = 0.007
Identities = 62/255 (24%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 159 SMYSQELFQLSQYLQEA-LHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRL 217
S E+ +L Q LQ + R+ K QRL + QEA + ++ D R L L
Sbjct: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK-RSQDDRARQLKGL 967
Query: 218 EVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQE-----------KI 266
E + S+ +TE K + L D+ N + LR L + KI
Sbjct: 968 E------EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKI 1021
Query: 267 EVVRKLSEVERSLSNTED------ECTHLKEMN----ERTQEELRE---LANKYNGAVNE 313
+ R+ +++ L+++E + L+ N ER Q E RE L + +
Sbjct: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK 1081
Query: 314 IKDLSDKLKVAEGKQEEIQQKGQAEK--KELQHKIDEMEEKEQEL-------QAKIEALQ 364
+K+LS +++ + +Q QK Q K L+ ++DE EE+ + L Q ++E
Sbjct: 1082 VKELS--IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQH 1139
Query: 365 ADNDFTNERLTALQE 379
N+ R+ +L++
Sbjct: 1140 EVNEQLQARIKSLEK 1154
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 107 bits (268), Expect = 3e-23
Identities = 157/646 (24%), Positives = 279/646 (43%), Gaps = 102/646 (15%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQAL-IDEDRLLS------RLEVMGNQLQACSKNQTED 234
L++ +A L + QEA + L +EDR+ + RLE L+ CS Q E
Sbjct: 1034 LDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLE-CSLEQ-EK 1091
Query: 235 SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSN----TEDECT--- 287
LR + + +ES+ Q+K ++ KL + + LS EDE
Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA 1151
Query: 288 ----HLKEMNERTQEELRELANKYNG----------AVNEIKDLSDKLKVAEGK---QEE 330
+KE+ R +E EL + A E+++LS++L+ A G Q E
Sbjct: 1152 QMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQRE 1211
Query: 331 IQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFT-NERLTALQEHLLSKSGGDC 389
+K +AE L+ +++E + + A + QA+ E++ +LQ
Sbjct: 1212 GCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR---------- 1261
Query: 390 TFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQ 449
+ Q +E +K L V++ + E TRAK S ++ L + E D ++A+
Sbjct: 1262 --VRQKLEKEKS-----ELRMEVDDLAANVETLTRAKAS--AEKLCRTYE---DQLSEAK 1309
Query: 450 MDEQDLNEPLAKVSLLKDDLQGAQSEIEAK-QEIQHLRKELIEAQELARTSKQKCFELQA 508
+ ++L LA S + LQ E+ +E + L +L + LA S + EL+
Sbjct: 1310 IKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLE---ELRR 1366
Query: 509 LLEEERKA-----------------YRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDS 551
LEEE KA R Q EE + LQ L + + + R + ++
Sbjct: 1367 QLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEA 1426
Query: 552 EITSTRDELLSARDEILLLHQAAAKVASERDTDIASL-------QEELKKVRAELERWRK 604
+ +EL A+ ++ L Q A + + +SL Q E + V ELER
Sbjct: 1427 DAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATS 1486
Query: 605 AASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENV 664
AA+ +K+ L+ + + R +Q E+ QRE LE ++E L TE L+ +
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRE--------LEAAQRESRGLGTELFRLRHGHE 1538
Query: 665 LLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLS 724
L+ ++E N Q++ +LT +S+ S +ELE +L+ + ++++ L
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE----GEKSEIQAALE 1594
Query: 725 KAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKN 770
+AE E E+T+T+ +L+L E +++ + ++ ++C N
Sbjct: 1595 EAEGAL-----ELEETKTLRIQLELSQVKAEVDRK-LAEKDEECAN 1634
Score = 94.4 bits (233), Expect = 4e-19
Identities = 149/625 (23%), Positives = 260/625 (41%), Gaps = 85/625 (13%)
Query: 186 LATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQE 245
L T+Q + + SW L + + L R +L A LR L A +
Sbjct: 860 LFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELR--GLRGALAAAEA 917
Query: 246 DKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL------------KEMN 293
+ E T + QEK ++ +L + +L++ E+ C HL KE++
Sbjct: 918 KRQELEETHVS----ITQEKNDLALQLQAEQDNLADAEERC-HLLIKSKVQLEGKVKELS 972
Query: 294 ERTQEE------LRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
ER ++E L K E+K D LK+ K E+ +Q + + K L ++
Sbjct: 973 ERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMA 1032
Query: 348 EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQF--IECQKKLIVE 405
++E L + +ALQ + L A ++ + + + Q +EC
Sbjct: 1033 ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLEC------- 1085
Query: 406 GHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLL 465
++E+ K + + RAK L + + + DA D+Q L E L K
Sbjct: 1086 -----SLEQEKKLRMDTERAKRK-----LEGDLKLTQESVADAAQDKQQLEEKLKKKD-- 1133
Query: 466 KDDLQGAQSEIEAKQEI-QHLRKELIEAQELARTSKQKCFELQALLEEERKA---YRNQV 521
+L +E +Q + ++K++ E Q A EL+ LE ER A Q
Sbjct: 1134 -SELSQLSLRVEDEQLLGAQMQKKIKELQARAE-------ELEEELEAERAARARVEKQR 1185
Query: 522 EESTKQIQVLQAQLQRLHIDTENLRE---EKDSEITSTRDELLSA--RDE--ILLLHQAA 574
E+ ++++ L +L+ + RE ++++E+ R EL A R E + L +
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245
Query: 575 AKVASERDTDIASLQ---EELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQ 631
A+ A+E + SLQ ++L+K ++EL + + +T + S + C+ EDQ
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 632 RE---EATRLQGELEKLRKEWNALETECHSLKR---ENVLLSSELQRQE----KELHNSQ 681
E + LQ +L + L+TE L R E L S+L R + + L +
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 682 KQSLELTSDLSILQMSRKELENQVGSLKEQHLRDS---ADLKTLLSKAENQAKDVQKEYE 738
+Q E + S L + + L + L+EQH ++ A+L+ LLSKA + + +YE
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 739 ----KTQTVLSELKLKFEMTEQEKQ 759
+ L E K K + QE +
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAE 1450
Score = 94.0 bits (232), Expect = 5e-19
Identities = 136/626 (21%), Positives = 253/626 (40%), Gaps = 91/626 (14%)
Query: 169 SQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS 228
S+Y +A+ R + LE+ L L +E + + + S LE +LQ S
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAA-------NAKCSSLEKAKLRLQTES 1474
Query: 229 KNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTH 288
++ T + R A DK RR +E+++ R+L +R E
Sbjct: 1475 EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQ--RELEAAQRESRGLGTELFR 1532
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDE 348
L+ +E E L L + EI DL+D++ ++ +E+++ +A
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKA----------- 1581
Query: 349 MEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHL 408
+E ++ E+QA +E + + + +Q L Q K V+ L
Sbjct: 1582 LEGEKSEIQAALEEAEGALELEETKTLRIQLEL----------------SQVKAEVDRKL 1625
Query: 409 TKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDD 468
+ EE + N RA ES + S D T A+ NE L LK
Sbjct: 1626 AEKDEECANLRRNHQRAVES---------LQASLDAETRAR------NEALR----LKKK 1666
Query: 469 LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQI 528
++G +++E ++ H ++ EAQ R + + E QA +EE++ E +Q
Sbjct: 1667 MEGDLNDLEL--QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL----AAELHEQA 1720
Query: 529 QVLQAQLQRLHIDTENLREEKDSEITSTR---DELLSARDEILLLHQAAAKVASER---D 582
Q L+ + L + E LR + S R ELL A + + LLH + +++ +
Sbjct: 1721 QALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780
Query: 583 TDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEAT-----R 637
D+A L E+++ E R+A + +K IT E+ ++E+ T R
Sbjct: 1781 ADLAQLSGEVEEAAQER---REAEEKAKKAITDA-------AMMAEELKKEQDTSAHLER 1830
Query: 638 LQGELEKLRKEWNALETECHSL-----KRENVLLSSELQRQEKELHNSQKQSLELTSDLS 692
++ LE+ +E A E K++ L ++++ E EL QK+ E +
Sbjct: 1831 MKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 1890
Query: 693 ILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFE 752
+ KEL Q E+ ++ A ++ L+ K +++ K ++++E+ + + K+
Sbjct: 1891 KHERRVKELAYQA----EEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYR 1946
Query: 753 MTEQEKQSITDELKQCKNNLKLLREK 778
+ E + + LR +
Sbjct: 1947 KAQHELDDAEERADMAETQANKLRAR 1972
Score = 77.4 bits (189), Expect = 5e-14
Identities = 109/503 (21%), Positives = 213/503 (42%), Gaps = 81/503 (16%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQ 223
ELF+L +EAL + L+++ LQ +E SD L ++ + G
Sbjct: 1529 ELFRLRHGHEEALEALETLKRENKNLQ------EEISD-----------LTDQVSLSGKS 1571
Query: 224 LQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTE 283
+Q K T+ +L E +Q E + + L+ ++E+ + +EV+R L+ +
Sbjct: 1572 IQELEK--TKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKD 1629
Query: 284 DECTHLKEMNERTQEELRELANKYNGAVNE-----------IKDLSDKLKVAEGKQEEIQ 332
+EC +L+ ++R E L+ + A NE + DL +L A + E Q
Sbjct: 1630 EECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQ 1689
Query: 333 ---QKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ QA+ KE Q DE + EL + +AL+ L L+ L
Sbjct: 1690 AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGE---- 1745
Query: 390 TFIHQFIECQKKLIVEGHLTKAVEETKLSKE------NQTRAKESDFSDTLSPSKEKSSD 443
+ + + E L +A E L NQ + E+D + LS E+++
Sbjct: 1746 ---------RSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQ-LSGEVEEAAQ 1795
Query: 444 DTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKC 503
+ +A E+ + + +++ ++L + E + ++ ++K T +Q
Sbjct: 1796 ERREA---EEKAKKAITDAAMMAEEL---KKEQDTSAHLERMKK----------TLEQTV 1839
Query: 504 FELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSA 563
ELQA LEE +A + KQ+Q L+A+++ L E D+E + L
Sbjct: 1840 RELQARLEEAEQA---ALRGGKKQVQKLEAKVR-------ELEAELDAEQKKHAEALKGV 1889
Query: 564 RDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLR 623
R + + A + +R ++A +Q+ + K++++++ +++ E E++ + ++ +
Sbjct: 1890 RKHERRVKELAYQAEEDR-KNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYR-K 1947
Query: 624 CQQCEDQQREEATRLQGELEKLR 646
Q D E A + + KLR
Sbjct: 1948 AQHELDDAEERADMAETQANKLR 1970
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/226 (25%), Positives = 105/226 (46%), Gaps = 44/226 (19%)
Query: 578 ASERDTDIASLQEELKKVRAEL---ERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREE 634
+++ + ++A+L+ EL+ +R L E R+ E IT +N L+ Q +D +
Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADA 950
Query: 635 ATR----------LQGELEKL------RKEWNA--------LETECHSLKRENVLLSSEL 670
R L+G++++L +E NA LE EC LK++ L L
Sbjct: 951 EERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK------TLLS 724
+ EKE ++ + LT +++ L S L + +L+E H + DL+ + L+
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070
Query: 725 KA----ENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK 766
KA E Q +D++ E+ E KL+ + TE+ K+ + +LK
Sbjct: 1071 KAKLRLEQQVEDLECSLEQ------EKKLRMD-TERAKRKLEGDLK 1109
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 19/188 (10%)
Query: 586 ASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKL 645
A +EEL +RAEL R A + E + L+ + Q+ D A +LQ E + L
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL----ALQLQAEQDNL 947
Query: 646 RKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQV 705
E CH L + V +L+ + KEL + E+ +DL+ R++LE++
Sbjct: 948 ADA----EERCHLLIKSKV----QLEGKVKELSERLEDEEEVNADLAA---RRRKLEDEC 996
Query: 706 GSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDEL 765
LK +D DLK L+KAE + + + + + ++ L +EK+++ +
Sbjct: 997 TELK----KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAH 1052
Query: 766 KQCKNNLK 773
+Q +L+
Sbjct: 1053 QQALGDLQ 1060
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 106 bits (264), Expect = 1e-22
Identities = 160/671 (23%), Positives = 286/671 (42%), Gaps = 110/671 (16%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D +++L LQ + QT D L+ E
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ-QTLDDLQAE-- 1019
Query: 242 ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELR 301
EDK N T AK I++ +++ ++E SL + L+ + + +L+
Sbjct: 1020 ---EDKVNTLTKAK----------IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 302 ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK---ELQHKIDEMEEKEQELQA 358
NE + L +KLK E + +Q K + E+ +LQ KI E++ + +EL+
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 359 KIEALQADNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGH-LTKA 411
+IEA +A ++ + L L L ++GG + IE KK E + +
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS---AQIEMNKKREAEFQKMRRD 1183
Query: 412 VEETKLSKENQT---RAKESDFS-------DTLSPSKEKSSDDTTDAQMDEQDLNEPLAK 461
+EE L E R K +D D L K+K + ++ +M+ DL +
Sbjct: 1184 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET 1243
Query: 462 VSLLKDDLQ-------GAQSEIEAKQEIQHLRKELIEAQ---------ELARTSKQKCFE 505
VS K +L+ SE+++K+E Q + AQ E +R +K
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK-EA 1302
Query: 506 LQALLEEERKAYRNQVEESTKQIQ-------VLQAQLQRLHIDTENLREEKDSEITSTRD 558
L + L ++A+ Q+EE +Q++ L LQ D + LRE+ + E S +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-KA 1361
Query: 559 ELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAASEY------ 609
EL A L +A +VA R +TD EEL++ + +L + +AA E+
Sbjct: 1362 ELQRA------LSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNA 1415
Query: 610 -----EKEITSLQNSFQ----------LRCQQCEDQQR----------EEATRLQGELEK 644
EK LQN + C + +QR ++ ELE
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 645 LRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQ 704
+KE +L TE +K +L+ ++E N Q++ +LT ++ ELE
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-- 1533
Query: 705 VGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE 764
+K+Q ++ +L+ L +AE + + + + Q L+++K + + EK D+
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 765 LKQCKNNLKLL 775
LK +N+++++
Sbjct: 1592 LK--RNHIRIV 1600
Score = 99.0 bits (245), Expect = 2e-20
Identities = 140/657 (21%), Positives = 291/657 (44%), Gaps = 64/657 (9%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
+S++L + + + +Q Q++ L+R L +A + AL L
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
+ Q SK + + +L K + + + YET A + + + K ++ ++L E +
Sbjct: 1353 YEEEQE-SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C L++ +R Q E+ +L N A+++ + DK+ +AE KQ EE
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI-LAEWKQKCEETH 1470
Query: 333 QKGQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ +A +KE L ++ +++ +E ++E L+ +N + ++ L E + GG
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE--GGKR 1528
Query: 390 TFIHQFIECQKKLIVEG-HLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDA 448
IH+ + +K++ E L A+EE + S E++ + L ++ KS D A
Sbjct: 1529 --IHELEKIKKQVEQEKCELQAALEEAEASLEHE---EGKILRIQLELNQVKSEVDRKIA 1583
Query: 449 QMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRK-----------ELIEAQELAR 497
+ DE+ + +++ +EI ++ + L+K +L A +A
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 498 TSKQKCFELQALLEEER----KAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---EEKD 550
+ + Q +L++ + A R+Q E+ +Q+ +++ + L + E LR E+ +
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAAS 607
ELL A + + LLH + + + +TDI+ +Q E++ + L+ R A
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI---LQEARNAEE 1759
Query: 608 EYEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL--- 659
+ +K IT E+ ++E+ T R++ +E+ K+ E L
Sbjct: 1760 KAKKAITDA-------AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Query: 660 --KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSA 717
K++ L + ++ E E+ + QK++ E L + KEL Q ++ LR
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872
Query: 718 DLKTLLSKAENQAKDVQKEYEKTQTVLSEL-KLKFEMTEQEKQSITDELKQCKNNLK 773
+ L +K ++ + ++ E++ T L++ KL+ E+ E E+++ E + K +K
Sbjct: 1873 LVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929
Score = 91.3 bits (225), Expect = 3e-18
Identities = 120/584 (20%), Positives = 249/584 (42%), Gaps = 86/584 (14%)
Query: 238 KELIALQED--KHNYETTAKESLRRVLQEKIEVVRK--------LSEVERSLSNTEDECT 287
KE+ ++E+ K E E+ R+ L+EK+ + K + L++ E+ C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
L + + + +++E+ + +EEI + A+K++L+ +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAE------------------DEEEINAELTAKKRKLEDECS 954
Query: 348 EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH 407
E+++ +L+ + ++ + T ++ L E + +G D T + +KK + E H
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM---AGLDETIAK--LTKEKKALQEAH 1009
Query: 408 LTK----AVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS 463
EE K++ + + K D L S E+ D + ++ L L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 464 LLKDDLQGAQSEIEAKQ-----EIQHLRKELIEAQELARTSKQKCFELQAL---LEEERK 515
D++ + +++ K EI +L+ ++ + Q L ++K ELQA LEEE +
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 516 AYRNQVEESTKQIQVLQAQLQRLHIDTE----------NLREEKDSEITSTRDELLSARD 565
A R ++ KQ L +L+ + E + +++++E R +L +
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL----E 1185
Query: 566 EILLLHQAAAKVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSL-------- 616
E L H+A A ++ D +A L E++ ++ ++ K SE + EI L
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 617 --QNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQE 674
+ + + C+ EDQ E L+ + E+ ++ N L + L+ E+ S +L +E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSE----LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Query: 675 KELHNSQKQSLELTSDLSILQMSRKELENQVGSLKE-----QHLRDSADLKTLLSKAENQ 729
+ + T + L +++LE ++ + Q R DL + E +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEEL---KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 730 AK-DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+K ++Q+ K T +++ + K+E ++ T+EL++ K L
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQR---TEELEEAKKKL 1399
Score = 89.7 bits (221), Expect = 1e-17
Identities = 139/663 (20%), Positives = 263/663 (39%), Gaps = 91/663 (13%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQ-EASDTSWQALIDEDRLLSRLEVMGNQLQ 225
QL + ++E R + LE+++ + A + + SD S + +RL Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 226 ACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
K + E +R++L +E +E TA ++ E+ ++ ++R E
Sbjct: 1169 MNKKREAEFQKMRRDL---EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 285 ECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQ--------QKG- 335
E + +K + + ++ + L D+L + K+EE Q Q+G
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR 1285
Query: 336 -QAEKKELQHKIDEME-------EKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGG 387
Q E E ++DE E +Q +IE L+ + + AL H L S
Sbjct: 1286 LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA-HALQSSRH 1344
Query: 388 DCTFIHQFIECQKKLIVEGHLTKAVEETKLSKEN----QTRAK-ESDFSDTLSPSKEKSS 442
DC + + E +++ +KA + LSK N Q R K E+D +E
Sbjct: 1345 DCDLLREQYEEEQE-------SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 443 DDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIE--------AKQEIQHLRKELIEAQE 494
Q E+ + AK + L+ Q Q+E+E L K+ +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 495 LARTSKQKCFELQALLEEERKAYR----------NQVEESTKQIQVLQAQLQRLHIDTEN 544
+ KQKC E A LE +K R N EES Q++ L+ + + L + +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 545 LREE------KDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAE 598
L E+ + E+ + ++ + E+ + A + I +Q EL +V++E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 599 LERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHS 658
++R +E ++EI L+ + +R + + R + + +L+K+
Sbjct: 1578 VDR---KIAEKDEEIDQLKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKK---------- 1623
Query: 659 LKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSAD 718
+ +L E +L+++ + + E + Q K+ + + + LR D
Sbjct: 1624 -------MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL----DDALRSQED 1672
Query: 719 LKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
LK L+ E +A +Q E E EL+ E TE+ ++ EL ++LL +
Sbjct: 1673 LKEQLAMVERRANLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 779 GNN 781
+
Sbjct: 1726 NTS 1728
Score = 75.1 bits (183), Expect = 2e-13
Identities = 115/566 (20%), Positives = 242/566 (42%), Gaps = 36/566 (6%)
Query: 169 SQYLQEALHREQMLEQ-KLATLQRLLAITQEASDTSWQ-ALIDEDRLLSRLEVMGNQLQA 226
++Y +A+ R + LE+ K QRL A + + + A +++ + + EV L
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 227 CSKNQTEDSLRKELI----ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNT 282
N +L K+ L E K E T E L +E + +L +++ + +
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAE-LEASQKEARSLGTELFKIKNAYEES 1497
Query: 283 EDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKEL 342
D+ LK N+ Q+E+ +L + I +L K E ++ E+Q + + L
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 343 QHKID-------EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQF 395
+H+ E+ + + E+ KI + D + E + S + +
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 396 IECQKKLIVEGHLTKAVEETKLSKENQTRAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQD 454
I +KK+ EG L + E +L+ N+ A+ ++ +T K+ + DA ++D
Sbjct: 1618 IRLKKKM--EGDLNEM--EIQLNHANRMAAEALRNYRNTQGILKD-TQIHLDDALRSQED 1672
Query: 455 LNEPLAKVSLLKDDLQGAQSEIEAK-QEIQHLRK----ELIEAQE---LARTSKQKCFEL 506
L E LA V + LQ E+ A ++ + RK EL++A E L T
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 507 QALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELL---- 561
+ LE + + ++E+ ++ + + + ++ D + EE K + TS E +
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1792
Query: 562 --SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNS 619
+ +D L L +A I L+ ++++ E+E +K +E K + +
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 620 FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
+ Q E+ R+ RLQ ++KL+ + + + + + ++ ++ ++ + EL
Sbjct: 1853 VKELTYQTEED-RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Query: 680 SQKQSLELTSDLSILQMSRKELENQV 705
+++++ S ++ L++ +E+ +V
Sbjct: 1912 AEERADIAESQVNKLRVKSREVHTKV 1937
Score = 73.9 bits (180), Expect = 5e-13
Identities = 96/492 (19%), Positives = 205/492 (41%), Gaps = 57/492 (11%)
Query: 334 KGQAEKKELQHKIDEMEEKEQELQAKIEA---------------------LQA------- 365
K +A++KEL+ K+ + +++ +LQ +++A L+A
Sbjct: 871 KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930
Query: 366 ---DNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK 416
D + N LTA + L L K D +E ++K E + EE
Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-KEKHATENKVKNLTEE-- 987
Query: 417 LSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA-QSE 475
++ ++T AK + L + +++ DD + L + K+ DDL+G+ + E
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 476 IEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQL 535
+ + +++ +++L +LA+ S +E E++ ++++ +I LQ+++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMD-------IENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 536 ---QRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEEL 592
Q L I + +E + I +E+ + R + + ++ E + L+E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 593 KKVRAELERWRKAASEYEKEITSLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW 649
A++E +K +E++K L+ + + + + L +++ L++
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 650 NALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLK 709
LE E +K E L+S ++ K N +K L LS L+ +E + + L
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 710 EQHLR---DSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK 766
Q R +S + L + E + + + + ELK + E + K ++ L+
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 767 QCKNNLKLLREK 778
+++ LLRE+
Sbjct: 1341 SSRHDCDLLREQ 1352
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/227 (22%), Positives = 106/227 (46%), Gaps = 31/227 (13%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++E + ++A+++EE +K++ EL + E E+++ +L +N QL+ Q
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 626 ------------QCEDQQREEATRLQGELE---KLRKEWNALETECHSLKRENVLLSSEL 670
Q E + +E R + E E +L + LE EC LK++ L L
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730
+ EKE H ++ + LT +++ L + +L + +L+E H + DL+ E++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKV 1023
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+ K K + + +L+ E ++ + + ++ + +LKL +E
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 106 bits (264), Expect = 1e-22
Identities = 160/671 (23%), Positives = 286/671 (42%), Gaps = 110/671 (16%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D +++L LQ + QT D L+ E
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ-QTLDDLQAE-- 1019
Query: 242 ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELR 301
EDK N T AK I++ +++ ++E SL + L+ + + +L+
Sbjct: 1020 ---EDKVNTLTKAK----------IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 302 ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK---ELQHKIDEMEEKEQELQA 358
NE + L +KLK E + +Q K + E+ +LQ KI E++ + +EL+
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 359 KIEALQADNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGH-LTKA 411
+IEA +A ++ + L L L ++GG + IE KK E + +
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS---AQIEMNKKREAEFQKMRRD 1183
Query: 412 VEETKLSKENQT---RAKESDFS-------DTLSPSKEKSSDDTTDAQMDEQDLNEPLAK 461
+EE L E R K +D D L K+K + ++ +M+ DL +
Sbjct: 1184 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET 1243
Query: 462 VSLLKDDLQ-------GAQSEIEAKQEIQHLRKELIEAQ---------ELARTSKQKCFE 505
VS K +L+ SE+++K+E Q + AQ E +R +K
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK-EA 1302
Query: 506 LQALLEEERKAYRNQVEESTKQIQ-------VLQAQLQRLHIDTENLREEKDSEITSTRD 558
L + L ++A+ Q+EE +Q++ L LQ D + LRE+ + E S +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-KA 1361
Query: 559 ELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAASEY------ 609
EL A L +A +VA R +TD EEL++ + +L + +AA E+
Sbjct: 1362 ELQRA------LSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNA 1415
Query: 610 -----EKEITSLQNSFQ----------LRCQQCEDQQR----------EEATRLQGELEK 644
EK LQN + C + +QR ++ ELE
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 645 LRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQ 704
+KE +L TE +K +L+ ++E N Q++ +LT ++ ELE
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-- 1533
Query: 705 VGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE 764
+K+Q ++ +L+ L +AE + + + + Q L+++K + + EK D+
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 765 LKQCKNNLKLL 775
LK +N+++++
Sbjct: 1592 LK--RNHIRIV 1600
Score = 99.0 bits (245), Expect = 2e-20
Identities = 140/657 (21%), Positives = 291/657 (44%), Gaps = 64/657 (9%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
+S++L + + + +Q Q++ L+R L +A + AL L
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
+ Q SK + + +L K + + + YET A + + + K ++ ++L E +
Sbjct: 1353 YEEEQE-SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C L++ +R Q E+ +L N A+++ + DK+ +AE KQ EE
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI-LAEWKQKCEETH 1470
Query: 333 QKGQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ +A +KE L ++ +++ +E ++E L+ +N + ++ L E + GG
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE--GGKR 1528
Query: 390 TFIHQFIECQKKLIVEG-HLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDA 448
IH+ + +K++ E L A+EE + S E++ + L ++ KS D A
Sbjct: 1529 --IHELEKIKKQVEQEKCELQAALEEAEASLEHE---EGKILRIQLELNQVKSEVDRKIA 1583
Query: 449 QMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRK-----------ELIEAQELAR 497
+ DE+ + +++ +EI ++ + L+K +L A +A
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 498 TSKQKCFELQALLEEER----KAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---EEKD 550
+ + Q +L++ + A R+Q E+ +Q+ +++ + L + E LR E+ +
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTE 1702
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAAS 607
ELL A + + LLH + + + +TDI+ +Q E++ + L+ R A
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI---LQEARNAEE 1759
Query: 608 EYEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL--- 659
+ +K IT E+ ++E+ T R++ +E+ K+ E L
Sbjct: 1760 KAKKAITDA-------AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812
Query: 660 --KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSA 717
K++ L + ++ E E+ + QK++ E L + KEL Q ++ LR
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1872
Query: 718 DLKTLLSKAENQAKDVQKEYEKTQTVLSEL-KLKFEMTEQEKQSITDELKQCKNNLK 773
+ L +K ++ + ++ E++ T L++ KL+ E+ E E+++ E + K +K
Sbjct: 1873 LVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVK 1929
Score = 91.3 bits (225), Expect = 3e-18
Identities = 120/584 (20%), Positives = 249/584 (42%), Gaps = 86/584 (14%)
Query: 238 KELIALQED--KHNYETTAKESLRRVLQEKIEVVRK--------LSEVERSLSNTEDECT 287
KE+ ++E+ K E E+ R+ L+EK+ + K + L++ E+ C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
L + + + +++E+ + +EEI + A+K++L+ +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAE------------------DEEEINAELTAKKRKLEDECS 954
Query: 348 EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH 407
E+++ +L+ + ++ + T ++ L E + +G D T + +KK + E H
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM---AGLDETIAK--LTKEKKALQEAH 1009
Query: 408 LTK----AVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS 463
EE K++ + + K D L S E+ D + ++ L L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 464 LLKDDLQGAQSEIEAKQ-----EIQHLRKELIEAQELARTSKQKCFELQAL---LEEERK 515
D++ + +++ K EI +L+ ++ + Q L ++K ELQA LEEE +
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 516 AYRNQVEESTKQIQVLQAQLQRLHIDTE----------NLREEKDSEITSTRDELLSARD 565
A R ++ KQ L +L+ + E + +++++E R +L +
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL----E 1185
Query: 566 EILLLHQAAAKVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSL-------- 616
E L H+A A ++ D +A L E++ ++ ++ K SE + EI L
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 617 --QNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQE 674
+ + + C+ EDQ E L+ + E+ ++ N L + L+ E+ S +L +E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSE----LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Query: 675 KELHNSQKQSLELTSDLSILQMSRKELENQVGSLKE-----QHLRDSADLKTLLSKAENQ 729
+ + T + L +++LE ++ + Q R DL + E +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEEL---KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 730 AK-DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+K ++Q+ K T +++ + K+E ++ T+EL++ K L
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQR---TEELEEAKKKL 1399
Score = 89.7 bits (221), Expect = 1e-17
Identities = 139/663 (20%), Positives = 263/663 (39%), Gaps = 91/663 (13%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQ-EASDTSWQALIDEDRLLSRLEVMGNQLQ 225
QL + ++E R + LE+++ + A + + SD S + +RL Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 226 ACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
K + E +R++L +E +E TA ++ E+ ++ ++R E
Sbjct: 1169 MNKKREAEFQKMRRDL---EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 285 ECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQ--------QKG- 335
E + +K + + ++ + L D+L + K+EE Q Q+G
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR 1285
Query: 336 -QAEKKELQHKIDEME-------EKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGG 387
Q E E ++DE E +Q +IE L+ + + AL H L S
Sbjct: 1286 LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA-HALQSSRH 1344
Query: 388 DCTFIHQFIECQKKLIVEGHLTKAVEETKLSKEN----QTRAK-ESDFSDTLSPSKEKSS 442
DC + + E +++ +KA + LSK N Q R K E+D +E
Sbjct: 1345 DCDLLREQYEEEQE-------SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 443 DDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIE--------AKQEIQHLRKELIEAQE 494
Q E+ + AK + L+ Q Q+E+E L K+ +
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 495 LARTSKQKCFELQALLEEERKAYR----------NQVEESTKQIQVLQAQLQRLHIDTEN 544
+ KQKC E A LE +K R N EES Q++ L+ + + L + +
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 545 LREE------KDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAE 598
L E+ + E+ + ++ + E+ + A + I +Q EL +V++E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 599 LERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHS 658
++R +E ++EI L+ + +R + + R + + +L+K+
Sbjct: 1578 VDR---KIAEKDEEIDQLKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKK---------- 1623
Query: 659 LKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSAD 718
+ +L E +L+++ + + E + Q K+ + + + LR D
Sbjct: 1624 -------MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL----DDALRSQED 1672
Query: 719 LKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
LK L+ E +A +Q E E EL+ E TE+ ++ EL ++LL +
Sbjct: 1673 LKEQLAMVERRANLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 779 GNN 781
+
Sbjct: 1726 NTS 1728
Score = 75.1 bits (183), Expect = 2e-13
Identities = 115/566 (20%), Positives = 242/566 (42%), Gaps = 36/566 (6%)
Query: 169 SQYLQEALHREQMLEQ-KLATLQRLLAITQEASDTSWQ-ALIDEDRLLSRLEVMGNQLQA 226
++Y +A+ R + LE+ K QRL A + + + A +++ + + EV L
Sbjct: 1379 TKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 227 CSKNQTEDSLRKELI----ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNT 282
N +L K+ L E K E T E L +E + +L +++ + +
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAE-LEASQKEARSLGTELFKIKNAYEES 1497
Query: 283 EDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKEL 342
D+ LK N+ Q+E+ +L + I +L K E ++ E+Q + + L
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 343 QHKID-------EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQF 395
+H+ E+ + + E+ KI + D + E + S + +
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 396 IECQKKLIVEGHLTKAVEETKLSKENQTRAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQD 454
I +KK+ EG L + E +L+ N+ A+ ++ +T K+ + DA ++D
Sbjct: 1618 IRLKKKM--EGDLNEM--EIQLNHANRMAAEALRNYRNTQGILKD-TQIHLDDALRSQED 1672
Query: 455 LNEPLAKVSLLKDDLQGAQSEIEAK-QEIQHLRK----ELIEAQE---LARTSKQKCFEL 506
L E LA V + LQ E+ A ++ + RK EL++A E L T
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 507 QALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELL---- 561
+ LE + + ++E+ ++ + + + ++ D + EE K + TS E +
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1792
Query: 562 --SARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNS 619
+ +D L L +A I L+ ++++ E+E +K +E K + +
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 620 FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
+ Q E+ R+ RLQ ++KL+ + + + + + ++ ++ ++ + EL
Sbjct: 1853 VKELTYQTEED-RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Query: 680 SQKQSLELTSDLSILQMSRKELENQV 705
+++++ S ++ L++ +E+ +V
Sbjct: 1912 AEERADIAESQVNKLRVKSREVHTKV 1937
Score = 73.9 bits (180), Expect = 5e-13
Identities = 96/492 (19%), Positives = 205/492 (41%), Gaps = 57/492 (11%)
Query: 334 KGQAEKKELQHKIDEMEEKEQELQAKIEA---------------------LQA------- 365
K +A++KEL+ K+ + +++ +LQ +++A L+A
Sbjct: 871 KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930
Query: 366 ---DNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK 416
D + N LTA + L L K D +E ++K E + EE
Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-KEKHATENKVKNLTEE-- 987
Query: 417 LSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGA-QSE 475
++ ++T AK + L + +++ DD + L + K+ DDL+G+ + E
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 476 IEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQL 535
+ + +++ +++L +LA+ S +E E++ ++++ +I LQ+++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMD-------IENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 536 ---QRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEEL 592
Q L I + +E + I +E+ + R + + ++ E + L+E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 593 KKVRAELERWRKAASEYEKEITSLQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEW 649
A++E +K +E++K L+ + + + + L +++ L++
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 650 NALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLK 709
LE E +K E L+S ++ K N +K L LS L+ +E + + L
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 710 EQHLR---DSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK 766
Q R +S + L + E + + + + ELK + E + K ++ L+
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 767 QCKNNLKLLREK 778
+++ LLRE+
Sbjct: 1341 SSRHDCDLLREQ 1352
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/227 (22%), Positives = 106/227 (46%), Gaps = 31/227 (13%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++E + ++A+++EE +K++ EL + E E+++ +L +N QL+ Q
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 626 ------------QCEDQQREEATRLQGELE---KLRKEWNALETECHSLKRENVLLSSEL 670
Q E + +E R + E E +L + LE EC LK++ L L
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730
+ EKE H ++ + LT +++ L + +L + +L+E H + DL+ E++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKV 1023
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+ K K + + +L+ E ++ + + ++ + +LKL +E
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 106 bits (264), Expect = 1e-22
Identities = 156/713 (21%), Positives = 301/713 (42%), Gaps = 116/713 (16%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGN 222
+EL + + ++ L Q LE+ +A LQ L + Q+ + L DE + S LE + +
Sbjct: 342 KELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKER----LSDELLVKSDLETVVH 397
Query: 223 QL----QACSKNQTEDSLRKELIALQ---------------------------EDKHNYE 251
QL Q SK ++ + + L+ E++ +Y
Sbjct: 398 QLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYY 457
Query: 252 TTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE--ELRELANKYNG 309
E L+ ++Q + + + S+ T ++ + E+++ T+E EL+ + ++
Sbjct: 458 KKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEK 517
Query: 310 AVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQ---------HKIDEMEEKEQELQ-AK 359
+ +I+ L K + + Q E L+ H I + EKE+EL +
Sbjct: 518 YMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSD 577
Query: 360 IEALQADNDFTNERLTALQE-HLLSKSGGDCTFIHQFIEC-QKKLIVEGHLTKA----VE 413
+ + A+ + E+L ++E L KS + T H + C +L E + K+ ++
Sbjct: 578 LRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEH--LTCVNHQLESEKYELKSKVLIMK 635
Query: 414 ETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQ---DLNEPLAKVSLLKDDLQ 470
ET S EN+ + + FS S + ++ + ++EQ +++ ++S+ + +L+
Sbjct: 636 ETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELE 695
Query: 471 GAQSEIEAKQE-IQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQ 529
AQ++I+ +E I L ++ E A K+ ++++E+ + V+E T++I
Sbjct: 696 SAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTI----GVIDKEKDFLQETVDEKTEKIA 751
Query: 530 VLQ----------AQLQRLHIDTEN----LRE---EKDSEITSTRDELLSAR---DEILL 569
LQ AQ++ + + E+ L+E +D EI S R +L +A DE+
Sbjct: 752 NLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGR 811
Query: 570 LHQAAAKVASERDTDIASLQEELKKVRAELE---------------------RWRKAASE 608
+ A K D+A++ E +++ ELE RW +
Sbjct: 812 SREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAA 871
Query: 609 YEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSS 668
EKE L + FQ+ + ED + +A + +GE +R E +++TE L+ LL
Sbjct: 872 KEKENQDLLDRFQMLHNRAEDWE-VKAHQAEGESSSVRLELLSIDTERRHLRERVELLEK 930
Query: 669 ELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAEN 728
E+Q H + Q + +S L+ + E++ K L D + L+ L K ++
Sbjct: 931 EIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDE----KATVLNDLSSLRELCIKLDS 986
Query: 729 QAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNN 781
KD+ + L+ L+FE E +++ E K L R N
Sbjct: 987 -GKDIMTQQ------LNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKN 1032
Score = 86.7 bits (213), Expect = 8e-17
Identities = 145/685 (21%), Positives = 282/685 (41%), Gaps = 117/685 (17%)
Query: 139 SDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQE 198
S+V P+P P D A+ LQ A +R Q L+Q++ LQ LA+ +
Sbjct: 180 SEVSSYPVPQPDDPYIADL--------------LQVADNRIQELQQEVHQLQEKLAMMES 225
Query: 199 ASDTSWQALIDEDRLLSRLEVM------GNQLQACSKNQTEDSLRKELIALQEDKHNYET 252
+ + +R + RL V + L S+N+T + L L N +
Sbjct: 226 GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL--------NIQV 277
Query: 253 TAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRE---LANKYNG 309
+ + L+++I R+L E + ++++ E +L NE+ +EL E LA +
Sbjct: 278 DFLQQANKDLEKRI---RELMETKETVTS---EVVNLSNKNEKLCQELTEIDQLAQQLER 331
Query: 310 AVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDF 369
E+ + +DK + G+A KKE++ K+ EM Q+L+ + LQ + +
Sbjct: 332 HKEEVLETADK------------ELGEA-KKEIKRKLSEM----QDLEETMAKLQLELNL 374
Query: 370 TNERLTALQEHLLSKSGGDCTFIHQFIECQKKL--------IVEGHLTKAVEETKLSKEN 421
+ L + LL KS + T +HQ + +++L + E LT VE +L
Sbjct: 375 CQKEKERLSDELLVKSDLE-TVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGI 433
Query: 422 QTRAKESDFSDTLSPSKEKSSD---------------------------DTTDAQMDEQD 454
+ R + DT E+ D + ++ D
Sbjct: 434 KRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGD 493
Query: 455 LNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQ--ELARTSKQKCFELQALLEE 512
N + +++ +D+LQ E E +L+ A+ +L+ + EL AL +E
Sbjct: 494 YNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKE 553
Query: 513 --ERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKD----------SEITSTRDEL 560
+ A N V K+ ++ + L+R+ + E LRE+ + SE+ T + L
Sbjct: 554 STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHL 613
Query: 561 LSARDEI-LLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNS 619
++ ++ +KV ++T I SL+ +LK + +S + E+ SL+
Sbjct: 614 TCVNHQLESEKYELKSKVLIMKET-IESLENKLKVQAQKFSHVAGDSSHQKTEVNSLR-I 671
Query: 620 FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
+ Q+ D + + +GELE + + LE + L N+ ++S Q++E H
Sbjct: 672 VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDEL---NLKMTS----QDEEAHV 724
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDS---ADLKTLLSKAENQAKDVQKE 736
+K + + LQ + E ++ +L+E A +K ++S+ E+ +++
Sbjct: 725 MKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKET 784
Query: 737 YEKTQTVLSELKLKFEMTEQEKQSI 761
++ L+ + + +E +
Sbjct: 785 LVNRDREINSLRRQLDAAHKELDEV 809
Score = 55.8 bits (133), Expect = 2e-07
Identities = 78/442 (17%), Positives = 175/442 (39%), Gaps = 34/442 (7%)
Query: 214 LSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTA------KESLRRVLQEKIE 267
+ R E+ Q Q + D L ++ + E+ H + T K+ L+ + EK E
Sbjct: 689 IKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTE 748
Query: 268 VVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGK 327
K++ ++ +L+N E +K M + + +L EI L +L A +
Sbjct: 749 ---KIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKE 805
Query: 328 QEEIQQKGQA---EKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSK 384
+E+ + + E + LQ + M + QE+ ++EA + + E + + +++
Sbjct: 806 LDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKE---EMKSRVHKYITEV 862
Query: 385 SGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDD 444
S + + E Q L L E+ ++ K +Q + S L +
Sbjct: 863 SRWESLMAAKEKENQDLLDRFQMLHNRAEDWEV-KAHQAEGESSSVRLELLSIDTERRHL 921
Query: 445 TTDAQMDEQDLNEPLAKVSLLKDDLQG-AQSEIEAKQEIQHLRKELIEAQELARTSKQKC 503
++ E+++ E + + + A++ ++E++H E + ++ C
Sbjct: 922 RERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELC 981
Query: 504 FELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSA 563
+L + + T+Q+ + +R+ ++ EN++ E D +E +
Sbjct: 982 IKLDS-----------GKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTV 1030
Query: 564 RDEILLLHQAAAK------VASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQ 617
++ LL K + E+DT+I L+E+L ++L + + ++ LQ
Sbjct: 1031 KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQ 1090
Query: 618 NSFQLRCQQCEDQQREEATRLQ 639
+ +Q ++ E +Q
Sbjct: 1091 TDYDALKRQISTERYERERAIQ 1112
Score = 46.6 bits (109), Expect = 9e-05
Identities = 73/387 (18%), Positives = 168/387 (43%), Gaps = 42/387 (10%)
Query: 172 LQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQ 231
LQE L + E+ +A ++ +++ + + + + L++ DR ++ L QL A K
Sbjct: 753 LQENLANK---EKAVAQMKIMISECESSVNQLKETLVNRDREINSLR---RQLDAAHKEL 806
Query: 232 TEDSLRKELIALQEDKH---NYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTH 288
E +E IA +E++ + T A+E+ + + E V++ E++ + E +
Sbjct: 807 DEVGRSRE-IAFKENRRLQDDLATMAREN-QEISLELEAAVQEKEEMKSRVHKYITEVSR 864
Query: 289 LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDE 348
+ + ++E ++L +++ N +D K AEG+ ++ + + E +H +
Sbjct: 865 WESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRER 924
Query: 349 MEEKEQELQAKIEALQADNDFTN---ERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVE 405
+E E+E+Q I A A + + ++ L+E L + T ++ ++ I
Sbjct: 925 VELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCI-- 982
Query: 406 GHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLL 465
++ K Q +K +F E+ + + + + L + L+
Sbjct: 983 -----KLDSGKDIMTQQLNSKNLEF--------ERVVVELENVKSESDLLKKQLSNERHT 1029
Query: 466 KDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEEST 525
+L+ + K+ HL TS +K E+Q LL+E+ +++ +
Sbjct: 1030 VKNLESLLATNRDKEFHSHL------------TSHEKDTEIQ-LLKEKLTLSESKLTSQS 1076
Query: 526 KQIQVLQAQLQRLHIDTENLREEKDSE 552
++ +L+A++ +L D + L+ + +E
Sbjct: 1077 RENTMLRAKVAQLQTDYDALKRQISTE 1103
Score = 43.9 bits (102), Expect = 6e-04
Identities = 66/359 (18%), Positives = 149/359 (41%), Gaps = 26/359 (7%)
Query: 427 ESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLR 486
E FSD + ++ + + +++ N ++ + ++ E E+ LR
Sbjct: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
Query: 487 KELIEAQELARTSKQKCFELQALLEEERKAYRNQV-----EESTKQIQVLQAQLQRLHID 541
+ + + +TS +KC A L+ Y +++ E K ++ Q Q + LH
Sbjct: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
Query: 542 TENLREEKDSEITSTRDELLSARDEILLLHQAA------------AKVASERDTDIASLQ 589
+ +K S I R + DE + + + A + D I LQ
Sbjct: 154 VQTPGGKKRS-IAFRRQRM--QIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQ 210
Query: 590 EELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEW 649
+E+ +++ +L +Y K+I + + + + + L+ + K
Sbjct: 211 QEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI 270
Query: 650 NALETECHSLKRENVLLSSELQR--QEKELHNSQKQSLELTSDLSILQMSR-KELENQVG 706
L + L++ N L ++ + KE S+ +L ++ +++ +L Q+
Sbjct: 271 AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLE 330
Query: 707 SLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDEL 765
KE+ L ++AD + L +A+ + K E + + +++L+L+ + ++EK+ ++DEL
Sbjct: 331 RHKEEVL-ETADKE--LGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL 386
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 106 bits (264), Expect = 1e-22
Identities = 141/657 (21%), Positives = 277/657 (42%), Gaps = 67/657 (10%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLAITQEASDT--SWQALIDEDRLLSRLEVMGNQLQ 225
L + L A + L + LA ++ ++ + DT AL+ E+R E+ + L+
Sbjct: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLE 1561
Query: 226 ACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVER-------S 278
S + + +SL+ L L EDK + + E E K E+++ S
Sbjct: 1562 NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS 1621
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
N +E ++ + E ++E +EL K K+ +L+ AE + EE+++K +
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF 1681
Query: 339 KKELQHKIDEMEEKEQELQAKI-----------EALQADNDFTNERL--TALQEHLLSKS 385
K Q KI E+EE+ L+A++ E L + N E L ++ LSK
Sbjct: 1682 AKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKK 1741
Query: 386 GGDCTFIHQFI--ECQK-KLIVEGHLTKAVE-ETKLSKENQTRAKESDFSDTLSPSKEKS 441
+ E Q K +EG+++K E +NQT E ++E+
Sbjct: 1742 FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD 1801
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
S + + + + + D Q+I L++ + +E KQ
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE----EKQ 1857
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
K E LE E+ +Q+ ++++LQ ++ ++++ + ++EE S +T ++
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL-SRVTKLKETAE 1916
Query: 562 SARDEI--LLLHQAAAKVASERD--TDIASLQEELKKVRAELERWRKAASEYEKEITSLQ 617
+D++ L++Q A S + D+ Q + + + +E++ +K SE E+E
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE----- 1971
Query: 618 NSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKEL 677
+ Q +++ + E+ + LEK++ + H+ + + +L E Q++ K+L
Sbjct: 1972 -----KQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL--KEKQQEVKQL 2024
Query: 678 HNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEY 737
QK + +S L+ + K LE ++ + +D K L++A K Q E
Sbjct: 2025 ---QKDCIRYQEKISALERTVKALE----FVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
Query: 738 ------------EKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNK 782
E + + LKLK E+ + K+S+ ++KQ +L+ E+ K
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKKEL-QSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Score = 100 bits (250), Expect = 4e-21
Identities = 140/642 (21%), Positives = 272/642 (42%), Gaps = 72/642 (11%)
Query: 167 QLSQYLQEALHREQMLEQKL----ATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGN 222
Q++Q LQ+ ++ +L+ ++ A +Q+L+ +ASD AL+ E ++S
Sbjct: 1096 QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVIS------- 1148
Query: 223 QLQAC--SKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
C S + L ++++AL+++K + + L+ L + +++K E ER L
Sbjct: 1149 --PPCTGSSEHWKPELEEKILALEKEKEQLQ----KKLQEALTSRKAILKKAQEKERHL- 1201
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVA-EGKQEEI-QQKGQAE 338
+E K+ R QE+ E + + ++++ L +++ + +GK QQ+ +
Sbjct: 1202 --REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSS 1259
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIEC 398
L+ + + E+ L D +E +ALQ GG T + Q
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ-------GG--TSVAQIKAQ 1310
Query: 399 QKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEP 458
K++ E K E K+S K+S+ L +E+ + + + + +E
Sbjct: 1311 LKEIEAE----KVELELKVSSTTSELTKKSEEVFQL---QEQINKQGLEIESLKTVSHEA 1363
Query: 459 LAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYR 518
L+ L+ +Q +I + ++ L+ +L E Q+L ++ L L E+ A
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
Query: 519 NQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLS-------------ARD 565
E +Q +++A LH E +E D I + EL A+
Sbjct: 1424 KIQTEIIEQEDLIKA----LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 566 EILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQ 625
+I QAA E + SLQEEL R +ER K+ ++ E ++ S QN +
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV-SAQNKEKDTVL 1538
Query: 626 QCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNS----- 680
+EE +L E+++ E +L + C SLK L+ + ++ KE+ +
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 681 ------QKQSLELTSDLSILQMSRKELENQVGSLK---EQHLRDSADLKTLLSKAENQAK 731
Q++ EL + IL S + + N+ ++ E ++ +L L E K
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 732 DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
+ +K+ ++ + + E+K K + KQ EL++ + L+
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLR 1700
Score = 95.1 bits (235), Expect = 2e-19
Identities = 151/687 (21%), Positives = 286/687 (41%), Gaps = 125/687 (18%)
Query: 167 QLSQYLQEALHREQMLEQKLAT--LQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQL 224
+L + Q+ + + +E ++ L+++ +E + S + E LL + QL
Sbjct: 1967 ELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE--LLKEKQQEVKQL 2024
Query: 225 QA-CSKNQTEDS-LRKELIALQ----EDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
Q C + Q + S L + + AL+ E + + E T KE+L + ++ + + +L+ +
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLEIT-KENLAQAVEHRKKAQAELASFKVL 2083
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
L +T+ E + N + ++EL+ +NK +++K + L E + E+ ++K E
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQ--SNK-ESVKSQMKQKDEDL---ERRLEQAEEKHLKE 2137
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIEC 398
KK +Q K+D + ++ L+ I +Q + ++ + LQE+L S T + F +
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS----TVTQLAAFTKS 2193
Query: 399 QKKLIVEGHLTKAVEETK----------LSKENQTRAKESDFSDTLSPSKEKS------- 441
L + + ++E K SKE + R KE + S ++ S
Sbjct: 2194 MSSL--QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 442 ---SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAK-QEIQHL----RKELIEAQ 493
S D Q+ E + + D LQG E+ ++ +E +HL + EL + +
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
Query: 494 ELARTSK----------QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQ------- 536
++ K +KC E + LE + ++ S + L+ LQ
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371
Query: 537 RLH----------------------IDTENLREEKDSEITSTRDELLSARDEILLLHQAA 574
RLH + LR++ D EI + L +E ++L +
Sbjct: 2372 RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN 2431
Query: 575 AKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREE 634
K + + L E LK ++ E + + + K ++SLQN R + D Q+ E
Sbjct: 2432 KKAVDKTN----QLMETLKTIKKENIQQKAQLDSFVKSMSSLQND---RDRIVGDYQQLE 2484
Query: 635 ATRLQ-------------GELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELH--- 678
L E KL++E L + L EN L +EL + ++L+
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 679 ----NSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDS----ADLKTLLSKAENQA 730
+ QKQ LE + KELEN+ L+E+ L++S DL+ + + +
Sbjct: 2545 TIKDSQQKQLLE------VQLQQNKELENKYAKLEEK-LKESEEANEDLRRSFNALQEEK 2597
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQE 757
+D+ KE E + +S+L + ++E
Sbjct: 2598 QDLSKEIESLKVSISQLTRQVTALQEE 2624
Score = 90.1 bits (222), Expect = 7e-18
Identities = 123/597 (20%), Positives = 247/597 (41%), Gaps = 71/597 (11%)
Query: 219 VMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERS 278
V+ +QL+ S + E L+ + L+ DK +E+ A+ ++ LQ+K V L +
Sbjct: 2235 VLKDQLRQMSIHMEE--LKINISRLEHDKQIWESKAQTEVQ--LQQK--VCDTLQGENKE 2288
Query: 279 LSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAE 338
L + +E HL + Q EL +L ++ +++ DLS+ L+ + ++ ++ + +
Sbjct: 2289 LLSQLEETRHLYHSS---QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQ 2345
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFI-- 396
+ ++Q+ E+ E +LQA E +E + ++ ++S G I I
Sbjct: 2346 EADIQNSKFSYEQLETDLQASRELTSR----LHEEINMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 397 ------------------ECQKKLIVEGHLTKAVEETK--------LSKEN-QTRAKESD 429
E ++ +++E KAV++T + KEN Q +A+
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 430 FSDTLSPSKEKSSDDTTDAQMDE-----------QDLNEPLAKVSLLKDDLQGAQSEIE- 477
F ++S + D Q E Q + E A+ + LK++++G +S ++
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 478 AKQEIQHLRKELIEAQE-------LARTSKQKCFELQALLEEERKAYRNQVEESTKQIQV 530
E L ELI+ +E + + +++ E+Q +E + ++EE K+ +
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 531 LQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQE 590
L+R + +++ EI S + + ++ L + + +E
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVK--EE 2639
Query: 591 ELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWN 650
E+ ++ A +K +E E+E+ +Q + + ED+ ++E L + +R E
Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
Query: 651 ALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKE 710
E L R+ V + +L KE Q +S LQ SR ++ LK
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
Query: 711 QHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQ 767
++ A LK L E + +++ +LSE TE+ S ++L Q
Sbjct: 2760 KY---DASLKELAQLKEQGLLNRERD-----ALLSETAFSMNSTEENSLSHLEKLNQ 2808
Score = 85.1 bits (209), Expect = 2e-16
Identities = 149/676 (22%), Positives = 271/676 (40%), Gaps = 120/676 (17%)
Query: 159 SMYSQELFQLSQYLQEALH-----REQMLEQKLATLQRLLAITQEAS----DTSWQALID 209
+M Q++ L +EA+ Q ++++ L+ LL+ +E + + + +A+
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Query: 210 EDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKH----NYETTAKESLRRVL--- 262
++L+ L+ + + + + DS K + +LQ D+ +Y+ + L +L
Sbjct: 2438 TNQLMETLKTI--KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKD 2495
Query: 263 ---QEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSD 319
QE KL E R L + D+ L N + EL + N + IKD
Sbjct: 2496 QLIQEAAAENNKLKEEIRGLRSHMDD---LNSENAKLDAELIQYREDLNQVIT-IKDSQQ 2551
Query: 320 KLKVAEGKQEEIQQKGQAEKK--ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTAL 377
K + + ++QQ + E K +L+ K+ E EE ++L+ ALQ + ++ + +L
Sbjct: 2552 KQLL----EVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL 2607
Query: 378 QEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPS 437
+ I Q L EG L + K+ +E R S
Sbjct: 2608 K-----------VSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL-----------S 2645
Query: 438 KEKSSDDTTDAQMDEQDL---NEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQE 494
SS A+++E+ + E KV ++D L K+E++HL + +
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL---------KKELKHLHHDAGIMRN 2696
Query: 495 LARTSKQKCFEL-QALLEEERKAYRNQVEES--TKQIQVLQAQLQRLHIDTENLREEKDS 551
T++++ EL + L+E E+K E T QIQ + L ++ EE D
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 552 ----------EITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQ----------EE 591
E+ +++ L R+ LL + A + S + ++ L+ E+
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 592 LKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNA 651
L + ++LE + K + SLQN E L ELEK RK
Sbjct: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQN---------------ERDHLWNELEKFRKSEEG 2861
Query: 652 LE----------TECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKEL 701
+ E SLK+ L ++ R KEL N Q+Q L++ +++ L + +L
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921
Query: 702 ENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSI 761
+ K + + LS Q + Q EK+ + E ++K EQ +I
Sbjct: 2922 QEYQDKTKAFQIMQEELRQENLSW---QHELHQLRMEKSSWEIHERRMK----EQYLMAI 2974
Query: 762 TDELKQCKNNLKLLRE 777
+D+ +Q + L+RE
Sbjct: 2975 SDKDQQLSHLQNLIRE 2990
Score = 83.2 bits (204), Expect = 9e-16
Identities = 109/491 (22%), Positives = 213/491 (43%), Gaps = 70/491 (14%)
Query: 328 QEEIQQK-GQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSG 386
QE++Q++ AE+ ++ K D + +K+ +LQ K EALQ + + ++ L+ H +K
Sbjct: 47 QEDVQERLAYAEQLVVELK-DIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAK-- 103
Query: 387 GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKE------------------- 427
T ++++IE K T+ E +LSK +++ +E
Sbjct: 104 --LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIS 161
Query: 428 ---SDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQH 484
+ + + +SS + + M +Q L E +S L+ L Q+E A+Q ++
Sbjct: 162 TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
Query: 485 LRK--------------ELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQV 530
+L+ ++ +QK LQ LEE ++ + + Q
Sbjct: 222 KDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE 281
Query: 531 LQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQE 590
L A QR I ++ L ++ ++E + R+ + + R+E +L + +ER +LQE
Sbjct: 282 LTAAEQRNQILSQQL-QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE 340
Query: 591 ELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWN 650
E+ + + E+ +A +E E ++L E + + E + L+K
Sbjct: 341 EMHHLLEQFEQAGQAQAELESRYSAL-----------EQKHKAEMEEKTSHILSLQKTGQ 389
Query: 651 ALETECHSLKREN-----------VLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRK 699
L++ C +LK +N V + +Q+ E +L Q++S E++ L+ L + +
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQL---QQKSKEISQFLNRLPLQQH 446
Query: 700 ELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQ 759
E +Q S + + + T + A Q + V+ E EK +LS ++L+ E EK
Sbjct: 447 ETASQT-SFPDVY-NEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL 504
Query: 760 SITDELKQCKN 770
S L + +N
Sbjct: 505 SSQITLLEAQN 515
Score = 82.4 bits (202), Expect = 2e-15
Identities = 119/635 (18%), Positives = 270/635 (42%), Gaps = 78/635 (12%)
Query: 183 EQKLATLQRLLAITQEASDTSWQALI------------DEDRLLSRLEVMGNQLQACSKN 230
E L +++ A T+ S TS + + D D+ LS + +G C ++
Sbjct: 629 ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQ----CHQD 684
Query: 231 QTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLK 290
+ E L+ +++ L+ + H + +++L +E + + + E +++ N T L
Sbjct: 685 ELE-RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 291 EMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEME 350
E ++ +++EL+ ++K L L AE ++ + A L +I +
Sbjct: 744 EERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLS 802
Query: 351 EKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEG---- 406
+ + KIE LQ N+ + +L ++ L +S + ++ ++ ++EG
Sbjct: 803 IEAKSKDVKIEVLQ--NELDDVQLQFSEQSTLIRS------LQSQLQNKESEVLEGAERV 854
Query: 407 -HLTKAVEET---------KLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQD-- 454
H++ VEE +++K +Q ++ +TL + E+ T+ +
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 455 --LNEPL----AKVSLLKDDLQGAQSEIEAKQE--------IQHLRKELIEAQELARTSK 500
LNE ++ LK+ L EAK+E L++ E + SK
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 501 QKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEIT---STR 557
++ LL++E + + +++ + + L ++ RL + NL++E EI + R
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETER 1034
Query: 558 DELLSARDEILLLHQAAAKVASERDT----DIASLQEELKKVRAELERWRKAASEYEKEI 613
E+ ++ + E + I+ + EL+ +R +LE A +++ +
Sbjct: 1035 GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALV 1094
Query: 614 TSLQNSFQLRCQQCEDQQREEATRLQGELEKL-RKEWNALETECHSLKRENVLLSSELQR 672
+ + Q + Q D + E + Q ++KL +A + + +L +E V++S
Sbjct: 1095 KQMNQTLQDKTNQI-DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
Query: 673 QEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKD 732
+S+ EL + L+ +++L+ ++ K +L KA+ + +
Sbjct: 1154 ------SSEHWKPELEEKILALEKEKEQLQKKLQEALTSR-------KAILKKAQEKERH 1200
Query: 733 VQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQ 767
+++E ++ + + L+ +F+ +E ++I D+L+Q
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ 1235
Score = 82.0 bits (201), Expect = 2e-15
Identities = 136/653 (20%), Positives = 264/653 (40%), Gaps = 118/653 (18%)
Query: 180 QMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLS--------RLEVMGNQLQACSKNQ 231
+ LE LA +R + E+ L ++ LS ++EV+ N+L
Sbjct: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Query: 232 TEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKE 291
+E S + +LQ N E+ E RV + K+ E+ ++LS E E T + +
Sbjct: 827 SEQSTL--IRSLQSQLQNKESEVLEGAERVRH----ISSKVEELSQALSQKELEITKMDQ 880
Query: 292 M---NERTQEELRELANKYNGAVNEI----------------------KDLSDKL----K 322
+ +R E L++ + + V EI K L ++L +
Sbjct: 881 LLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR 940
Query: 323 VAEGKQEEIQQK-----------------GQAEKKELQHKIDEMEEKEQELQAKIEALQA 365
E K+E++++ GQ K+ELQH+ D ++++ ++ + K++A
Sbjct: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000
Query: 366 DNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRA 425
+ +R++ L+E L + E +K++ + VEE K +KE +
Sbjct: 1001 NRKELLQRVSRLEEELANLKD----------ESKKEIPLSETERGEVEEDKENKEYSEKC 1050
Query: 426 KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAK-QEIQH 484
S + K+ S+ + Q +DL E LA + ++ ++ K +I
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 485 LRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTEN 544
L+ E+ E Q + +Q L+ A K+ V+ +
Sbjct: 1111 LQAEISENQAI----------IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
Query: 545 LREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRK 604
EEK + +++L E L +A K A E++ L+EELK+ + + R ++
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKE---RHLREELKQQKDDYNRLQE 1217
Query: 605 AASEYEKEITSLQNSF-QLRCQQCED--------QQREEATRLQGELEKLRK-------- 647
E KE ++ + QL+ Q E Q+E + G E L K
Sbjct: 1218 QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
Query: 648 ---------EWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSR 698
+W + + +L+ + ++++ Q KE+ ++K LEL + ++++
Sbjct: 1278 PVLESNLCPDWPSHSEDASALQGGTSV--AQIKAQLKEI-EAEKVELELKVSSTTSELTK 1334
Query: 699 KELENQVGSLKEQHLRDSAD---LKTLLSKAENQAKDVQKEYEKTQTVLSELK 748
K +V L+EQ + + LKT+ +AE A+ +Q++ E +Q ++ L+
Sbjct: 1335 K--SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE 1385
Score = 81.3 bits (199), Expect = 3e-15
Identities = 161/761 (21%), Positives = 318/761 (41%), Gaps = 138/761 (18%)
Query: 151 DKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDE 210
+K+ S+ S ++ + +++ ++ H+E E ++ LQ ++ EA Q +++
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEK--HKELQKEYEIL-LQSYENVSNEAERI--QHVVEA 1638
Query: 211 DRLLSRLEVMGN-QLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVV 269
R + E+ G + +K +TE L++ ++E K AK +++L+ + E
Sbjct: 1639 VRQ-EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 270 RKLSEVERSLSNTEDECTH--------LKEMNERTQEELRELANKYNGAVNEIKDLSDKL 321
R +EV + +T EC +KE ER + E L+ K+ ++E LS+++
Sbjct: 1698 RLRAEVHPA-GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV 1756
Query: 322 K----VAEGKQEEIQQKGQAEKKELQHKIDEM-------EEKEQEL-------------- 356
+ EG + EK + Q + E E +EQ+
Sbjct: 1757 QDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVP 1816
Query: 357 QAKIEALQADNDFTN--------ERLTALQEHL--LSKSGGDCTFIHQFIECQKKLIV-- 404
AK DF++ +++ L+E + L + Q +E +K ++
Sbjct: 1817 SAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQ 1876
Query: 405 ----EGHLTKAVEE-TKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDE------- 452
+G L EE TK++ NQ +E L + E+ DD + M++
Sbjct: 1877 ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
Query: 453 -----QDLNEPLAKVSLLKDDLQGAQ---SEIEA-KQEI--------QHLRKELIEAQEL 495
QD+ + K LL+ +++ + SE+E KQ++ +RKE +E +
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 496 ART---SKQKCFELQALLEEERKAYR-------------NQVEESTKQIQVLQAQLQR-L 538
A+ +K ELQ LL+E+++ + + +E + K ++ +Q + Q+ L
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL 2056
Query: 539 HIDTENL------REEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEEL 592
I ENL R++ +E+ S + L + E + K+ E ++ S++ ++
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 593 KKVRAELERWRKAASE-YEKEITSLQNSFQL-------------RCQQCEDQQREEATRL 638
K+ +LER + A E + KE ++Q Q +++ +E +L
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 639 QGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN---SQKQSLELTSD-LSIL 694
Q L+ + A SL+ + + E ++ E++ + S+++ + L D S+L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 695 QMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMT 754
+ +++ + LK R D + SKA+ + + QK + Q EL + E T
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 755 --------------EQEKQSITDELKQCKNNLKLLRE-KGN 780
E E +S+ D+L N+L+ +E KGN
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337
Score = 80.5 bits (197), Expect = 6e-15
Identities = 138/710 (19%), Positives = 284/710 (40%), Gaps = 131/710 (18%)
Query: 179 EQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRK 238
E ++QKL LQR L +E+ L+ R +V+ Q + + + +
Sbjct: 247 ETEMQQKLRVLQRKLEEHEES-------------LVGRAQVVDLLQQELTAAEQRNQILS 293
Query: 239 ELIALQEDKHN-----YETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMN 293
+ + E +HN ET +ES ++L EK+E+ +++E + S N ++E HL E
Sbjct: 294 QQLQQMEAEHNTLRNTVETEREES--KILLEKMEL--EVAERKLSFHNLQEEMHHLLEQF 349
Query: 294 ERTQEELRELANKYNG----------------------------AVNEIKDLSDKLKVAE 325
E+ + EL ++Y+ A + +KD + KL +
Sbjct: 350 EQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK 409
Query: 326 GKQ--------EEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADND----FTNER 373
+Q ++++ + Q + KE+ ++ + ++ E ++ N+ T E
Sbjct: 410 NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN 469
Query: 374 LTALQEHLLSKSGGDCTFIHQFIECQK------KLIVEGHLTKAVEETKLSKENQTRAKE 427
+ +LQ+ ++ + IE ++ KL + L +A T + +
Sbjct: 470 IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISI 529
Query: 428 SDFSDTLSPSKEKSSDDTTDAQMDEQ---------DLNEPLAKVSLLKDDLQGAQSEIEA 478
D ++ S S E+S D + ++ ++ E +++ LK LQG ++E
Sbjct: 530 VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD 589
Query: 479 KQEIQHLRKELIEAQELARTSKQKCF------ELQALLEEERKAYRNQVEESTKQIQVLQ 532
+ + + +E + +A K K F + + EE + E+++ + Q
Sbjct: 590 HEVLDQKEMKQMEGEGIAPI-KMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRT 648
Query: 533 AQ---LQRLHIDTENLREEKDSEITST-------RDELLSARDEILLLHQAAAKVASERD 582
++ L ++ ++ +++ D +++ +DEL + +IL L K +
Sbjct: 649 SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708
Query: 583 TDIASLQEELKKVRAELERWRKAASEYEKEITSLQNS--------------FQLRCQ--Q 626
++ +E+ + +E ++K A T+L +LR Q Q
Sbjct: 709 KNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQ 768
Query: 627 CEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
E E + + + E N L + HSL E +++ + EL + Q Q E
Sbjct: 769 LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE 828
Query: 687 LTSDLSILQMSRKELENQV--GSLKEQHLRDSAD-LKTLLSKAENQAKDV-------QKE 736
++ + LQ + E++V G+ + +H+ + L LS+ E + + +++
Sbjct: 829 QSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRD 888
Query: 737 YEKTQTVLSE-----LKLKFEMTE------QEKQSITDELKQCKNNLKLL 775
E Q + E ++ F MTE +EK S+ E+K K L LL
Sbjct: 889 VETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLL 938
Score = 61.2 bits (147), Expect = 4e-09
Identities = 103/489 (21%), Positives = 208/489 (42%), Gaps = 62/489 (12%)
Query: 190 QRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHN 249
Q+LL +T+E L ++++ G + S + D +EL E K
Sbjct: 2717 QKLLMVTKENKG-----------LTAQIQSFGRSMS--SLQNSRDHANEEL---DELKRK 2760
Query: 250 YETTAKESLRRVLQEKIEVVRK--LSEVERSLSNTEDEC-THLKEMNERT---QEELREL 303
Y+ + KE + Q + R LSE S+++TE+ +HL+++N++ E+L L
Sbjct: 2761 YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL 2820
Query: 304 ANKYNGAVNEIKDLSDKLKVAEGKQEEIQ------QKGQAEKKELQHKIDEMEEKEQELQ 357
+++ + N+++ S + + +++ + +K + K+ + + Q L+
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 358 AKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKL 417
+ +LQ D D + L LQ+ L + + T +H ++ L + ++TK
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYL-QINQEITELHP---------LKAQLQEYQDKTKA 2930
Query: 418 SKENQTRAKESDFS---DTLSPSKEKSSDDTTDAQMDEQ------DLNEPLAKVSLLKDD 468
+ Q ++ + S + EKSS + + +M EQ D ++ L+ + L +
Sbjct: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990
Query: 469 LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQI 528
L+ + S+ + + +Q+ R+ E S+ +E + L R Q+ +S K+I
Sbjct: 2991 LRSSSSQTQPLK-VQYQRQASPETSASPDGSQNLVYETELL--------RTQLNDSLKEI 3041
Query: 529 QVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEIL----LLHQAAAKVASERDTD 584
+ ++Q+L+ + L EEK++ D S R+ LL+ A ++
Sbjct: 3042 HQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101
Query: 585 IASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEK 644
L ++ + + S+ E E+ Q SF QQ R+E L+ LE+
Sbjct: 3102 AGPLNIDVAPGAPQEKNGVHRKSDPE-ELREPQQSFS-EAQQQLCNTRQEVNELRKLLEE 3159
Query: 645 LRKEWNALE 653
R + A E
Sbjct: 3160 ERDQRVAAE 3168
Score = 52.0 bits (123), Expect = 2e-06
Identities = 98/434 (22%), Positives = 172/434 (39%), Gaps = 69/434 (15%)
Query: 161 YSQELFQLSQYLQEAL---HREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLL--- 214
Y L +L+Q ++ L R+ +L + ++ + + Q L+ +D L
Sbjct: 2761 YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL 2820
Query: 215 -SRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEV--VRK 271
S+LE NQ+Q+ SK SL+ E L + + + + R Q V+
Sbjct: 2821 SSQLEDSYNQVQSFSKAMA--SLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
Query: 272 LSEVERSLSNTEDECTHLKEMNERTQE--ELRELANKYNGAVNEIKDLSDKLKVAEGKQE 329
L + SL N D LKE+ Q+ ++ + + + ++++ DK K + QE
Sbjct: 2879 LKKAMSSLQNDRDRL--LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE 2936
Query: 330 EIQQKGQAEKKELQH--------KIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL 381
E++Q+ + + EL +I E KEQ L A +D D L L L
Sbjct: 2937 ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAI-----SDKDQQLSHLQNLIREL 2991
Query: 382 LSKSGGDCTFIHQFI-----------ECQKKLIVEGHLTKAVEETKLS----KENQTRAK 426
S S Q+ + + L+ E L + L KE + +
Sbjct: 2992 RSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQL 3051
Query: 427 ESDFSDTLSPSKEKS---SDDTTDAQMDEQDLNEPLAKVSLLKDDLQ------------- 470
S+FS L S D + + ++Q + L ++L+ +Q
Sbjct: 3052 NSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAP 3111
Query: 471 GAQSE---IEAKQEIQHLRK---ELIEAQELARTSKQKCFELQALLEEERKAYRNQVEES 524
GA E + K + + LR+ EAQ+ ++Q+ EL+ LLEEE R+Q +
Sbjct: 3112 GAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEE----RDQRVAA 3167
Query: 525 TKQIQVLQAQLQRL 538
+ V + Q++RL
Sbjct: 3168 ENALSVAEEQIRRL 3181
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 105 bits (262), Expect = 2e-22
Identities = 146/659 (22%), Positives = 282/659 (42%), Gaps = 91/659 (13%)
Query: 123 STIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQML 182
+T+K + D A ++ ++ L +DKV N Q+L QL + Q R +
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALA--LDKVGLN------QQLLQLEEENQSVCSRMEAA 636
Query: 183 EQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI- 241
EQ LQ LA ++ + W+ + L + E G +LQA ++ E+ KE I
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE---KEEIQ 693
Query: 242 -ALQEDKHNYE--TTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQE 298
L E +H E TT E L + + + EV+ + + + +L + + ER ++
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 299 ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKG---QAEKKELQHKIDEMEEKEQE 355
+L E +++ LS ++ E E QQ+ + K +L+ +I + + ++
Sbjct: 754 DLAE----------QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803
Query: 356 LQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEET 415
+Q ++ L+ + D ER A QE + L +A +E
Sbjct: 804 IQGEVRCLKLELD--TERSQAEQE---------------------RDAAARQLAQAEQEG 840
Query: 416 KLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSE 475
K + E Q A E + + L EK + +Q+L + L + L+ + E
Sbjct: 841 KTALEQQKAAHEKEVNQ-LREKWEK------ERSWHQQELAKAL-------ESLEREKME 886
Query: 476 IEAKQEIQHLRKELIEAQ-ELARTSKQKCF-ELQALLEEERKAYRNQVEESTKQIQVLQA 533
+E + + Q E I+AQ E RT + ++Q E+ER + + ++ K++
Sbjct: 887 LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946
Query: 534 QLQRLHID--TENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEE 591
QL+RL D + L+E++ + I T +L A+ E+ + A + D+A+LQEE
Sbjct: 947 QLERLRQDMKVQKLKEQETTGILQT--QLQEAQREL-------KEAARQHRDDLAALQEE 997
Query: 592 LKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQRE--EATRLQGELEK----L 645
+ + +K + + ++ + +S +L Q+ +++ RE E R+Q ELE+ L
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 646 RKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQV 705
E L+ + + EL +++ +Q + EL++ + +L+ KE E
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE--- 1114
Query: 706 GSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE 764
L A L L + + ++ + ++L+L+ TE + +++ E
Sbjct: 1115 ----ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Score = 97.1 bits (240), Expect = 6e-20
Identities = 154/667 (23%), Positives = 280/667 (41%), Gaps = 115/667 (17%)
Query: 174 EALHREQMLEQKLAT--LQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQ 231
++L +E+ L QK Q+L + QEA W+ R+ L++ G+ Q + Q
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLEQEA----WRLR----RVNVELQLQGDSAQGQKEEQ 510
Query: 232 TEDS--LRKELIALQEDKHNYETTAKESLRRV--LQEKIEVVRKLSEVERSLSNTEDECT 287
E+ +E LQE E ESL + L+E +E E+ R E T
Sbjct: 511 QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQ------EQT 564
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
+ R ++ + EL++ N E+ DL + A K + + +K L ++
Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADL----RAAAVKLSALNEALALDKVGLNQQLL 620
Query: 348 EMEEKEQELQAKIEA-------LQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
++EE+ Q + +++EA LQ D +R AL E K
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE--------------------K 660
Query: 401 KLIVEGHLTKAVEE-TKLSKE-NQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLN-- 456
+E L KA E +L + + ++ + LS S+ + TT + Q+
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 457 -EPLAKVSLLKDDLQGAQSEIEAK-QEIQHLRKELIE-------AQELARTSKQKCFELQ 507
E LA+ K+ L ++ +E + Q ++ R++L E A+EL +S + +
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
Query: 508 ALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEI 567
+++E + Q++ T+ +V+Q +++ L ++ + R + + E + +L A E
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE- 839
Query: 568 LLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQC 627
K A E+ A+ ++E+ ++R E+W K S +++E+ S + +
Sbjct: 840 -------GKTALEQQK--AAHEKEVNQLR---EKWEKERSWHQQELAKALESLEREKMEL 887
Query: 628 E----DQQRE-EATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQK 682
E +QQ E EA + Q E E+ + E + + + K LL + LQ Q KEL ++ +
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ-KELADASQ 946
Query: 683 QSLELTSDLS-----------ILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAK 731
Q L D+ ILQ +E + ++ QH D A L+ S
Sbjct: 947 QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 732 DVQKEYEKTQTVL-----------SELKLKFEMT----------EQEKQSITDELKQCKN 770
D+QK+ E ++ L E++ K T E+EK S+T L + +
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 771 NLKLLRE 777
L +L+E
Sbjct: 1067 RLLVLQE 1073
Score = 93.6 bits (231), Expect = 7e-19
Identities = 135/660 (20%), Positives = 271/660 (41%), Gaps = 61/660 (9%)
Query: 153 VAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDR 212
V S+ QEL L Q +QEA ++ L ++ L+ QE + L E +
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR------QEVKEKEADFLAQEAQ 1123
Query: 213 LLSRLE---VMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVV 269
LL LE + QL+A Q + + +L + A++ Q + ++
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 270 RKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQE 329
S ++++L + + L + + + L NGA + K ++
Sbjct: 1184 SLYSALQQALGSVCESRPELSGGGD-SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 330 EIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
K + + Q D + ++ Q+L+ ++ +A+ + L LQ L
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 390 TFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQ 449
+ + + +L+ E H T A +++L + R + + L +KE + Q
Sbjct: 1303 KWEGKQNSLESELM-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 450 MDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKE----LIEAQELARTSKQKCFE 505
+ + +L++DL+ A+S ++ K E +E L E EL + E
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 506 LQALL-------EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTE------NLREEKDSE 552
ALL EEE + R Q++E KQ ++ +A L+ L +D + +L++E+ E
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
Query: 553 ITSTRDEL------LSARDEILLLHQAAAK-VASERDTDIASLQE---ELKKVRAELERW 602
+ R L + R++ L + + + + +R+T L+ EL+K +E
Sbjct: 1482 LEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ 1541
Query: 603 RKAASEYEKEITSLQ--------NSFQLRCQQC--------EDQQREEATRLQGELEKLR 646
R + +K++ +L+ N ++ CQQ + QR T L +LE+
Sbjct: 1542 RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERS 1601
Query: 647 KEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVG 706
+E A ++ H L+ + +L+ ELQ +++E+ + ++Q E LQ ++ L +
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE-------LQRQKEHLTQDLE 1654
Query: 707 SLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELK 766
++ + ++ L + Q K ++++ E+ + L E + Q Q +E K
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
Score = 89.7 bits (221), Expect = 1e-17
Identities = 149/679 (21%), Positives = 300/679 (44%), Gaps = 99/679 (14%)
Query: 164 ELFQLSQYLQEALHREQMLEQKLATLQRLLAITQE---ASDTSWQALIDEDRL-LSRLEV 219
EL + LQ L R ++ + + LL +E A QA + E R S +
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGI 1376
Query: 220 MGNQLQACS-----KNQTEDSLRKELIALQED---KHNYETTAKESLRRVLQ------EK 265
+ L+ KN+ +S R+ ALQE K +E+L + Q E+
Sbjct: 1377 LEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 266 IEVVR-KLSEVERSL----SNTEDECTHLKEMNERT---QEELRELANKYNGAVNE---- 313
+E +R ++ E+E+ + E LK+ N+ QE+++EL K +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL-EKCRSVLEHLPMA 1495
Query: 314 IKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNER 373
+++ KL V + E+++ + ++ L+H++ E+E+K+Q ++++ +Q ++
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD----LKKQ 1551
Query: 374 LTALQEHLLSKSGGDCTFIHQFIECQKKLI--VEGHL-TKAVEETKLSKENQTRAKESDF 430
L L+ L H +ECQ+KLI +EG T+ V T L+ + + R++E
Sbjct: 1552 LVTLECLALELEEN-----HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 431 -SDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKEL 489
S + + S+ + Q +Q++ ++ L+ + ++E + + L+KE
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 490 IEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ---------AQLQRLHI 540
I+ E RT + K E LE+ + + R + E T Q Q++Q ++ QR +
Sbjct: 1667 IQVLEDQRTRQTKILEED--LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL 1724
Query: 541 DTENL-REEKDSEITSTRD---ELLSARDEILL----LHQAAAKVA---SERDTDIASLQ 589
+ L +K+ E+ ++ EL +D++ LH+ + + S+R+ +I LQ
Sbjct: 1725 EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 590 EELKKVR-----------AELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRL 638
++L++ R ++L+ ++A ++ ++E+ +LQ Q + Q E++ +E+A L
Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE-QQQAQGQEERVKEKADAL 1843
Query: 639 QGELEK----LRKEWNALETECHSLKR---------------ENVL--LSSELQRQEKEL 677
QG LE+ L++ L+ +R E VL L +E + QEK L
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 678 HNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEY 737
Q+Q E + + + ++ Q ++ ++ ++ L+ + +Q + +
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA 1963
Query: 738 EKTQTVLSELKLKFEMTEQ 756
E Q L + + EQ
Sbjct: 1964 EALQEALGKAHAALQGKEQ 1982
Score = 87.4 bits (215), Expect = 5e-17
Identities = 138/645 (21%), Positives = 271/645 (42%), Gaps = 108/645 (16%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLA-ITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
L++ LQE + +++ LQR +TQ+ + ++ ++R+ +V+ +Q
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI----QVLEDQRTR 1676
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL------- 279
+K ED E I L + E T + R+++QE+ E + S+ +R
Sbjct: 1677 QTKILEEDL---EQIKLSLRERGRELTTQ---RQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 280 ---SNTEDECTH-----LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEI 331
E EC L+E+ ++ +++L+ L K + ++ V + + +E
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 332 QQKGQAEKKELQHKIDE----MEEKEQELQA---KIEALQADNDFTNERLTALQEHL--- 381
+++G+ +++ LQ ++DE + +++QEL+A + + Q + E+ ALQ L
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 382 ---LSKSGGDC-TFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPS 437
L + G+ Q +++L VEG +A+EE D + S
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV--------------LGDLRAES 1896
Query: 438 KEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELAR 497
+E+ +LL Q A+ E + E + L+ ++AQ + +
Sbjct: 1897 REQEK--------------------ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 498 TSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTR 557
Q EL+AL E + + R+Q E + + + LQ L + H + +
Sbjct: 1937 ERDQ---ELEALRAESQSS-RHQEEAARARAEALQEALGKAHAALQGKEQH--------- 1983
Query: 558 DELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQ 617
LL QA + E T A+LQ L +A + +A E EI
Sbjct: 1984 -----------LLEQAELSRSLEAST--ATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
Query: 618 NSFQLRCQQCED--QQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEK 675
+Q QQ + QR+E R Q E E+L ++ A + + ++ + L + + +
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
Query: 676 ELHNSQKQSLELT---SDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKD 732
LH S ++ L+LT + IL++ + N + +L H + ++L K ++
Sbjct: 2091 GLHQSVRE-LQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSL--KLDSLEPR 2147
Query: 733 VQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+Q+E E+ Q L + + + ++ Q + L Q K ++ L+E
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQE 2192
Score = 83.2 bits (204), Expect = 9e-16
Identities = 142/666 (21%), Positives = 282/666 (42%), Gaps = 95/666 (14%)
Query: 165 LFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQL 224
L +L Q L + +L ++ L+ L T+ L D R LS+ NQ
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ-----NQE 1299
Query: 225 QACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
+ ++SL EL+ L H + + LRR +++E + ++ + N
Sbjct: 1300 EKSKWEGKQNSLESELMEL----HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Query: 285 ECTHLKE--MNERTQ--------EELRELANKYNGAVNEIKDLSDK---------LKVAE 325
+ HL+ + R Q E+LR + E++ ++ LKVA+
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 326 GK--QEEIQQKGQ--AEKKE----LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTAL 377
GK QE + Q AE++E L+ +I E+E++ + +A +E L D N+ +
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 378 QEHL--LSKSGGDCTFIHQFI-ECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
QE + L K + + E ++KL V+ + + E + +E Q E +
Sbjct: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQ---REQIRELEKDRETQRNVLEHQLLEL- 1531
Query: 435 SPSKEKSSDDTTDAQMDE-QDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQ 493
+ D ++Q + QDL + L + L +L+ ++E +Q++ + E Q
Sbjct: 1532 -----EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ 1586
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
+A T E ++ +E +A +Q+ + VL +LQ + ++ RE+ + E+
Sbjct: 1587 RVALTHLTLDLEERS---QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE-EL 1642
Query: 554 TSTRDEL---LSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYE 610
++ L L RD+ L+L + +V ++ T + EE +LE+ + + E
Sbjct: 1643 QRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE------DLEQIKLSLRERG 1696
Query: 611 KEITSLQNSFQLRCQQCEDQQREEATRL-----------------QGELEKLRKEWNALE 653
+E+T+ + Q R ++ + + + L Q + +L++ + LE
Sbjct: 1697 RELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE 1756
Query: 654 TECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHL 713
+ L R+ S L ++E+E+ Q+Q LQ +R++ G LKEQ L
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQ----------LQEAREQ-----GELKEQSL 1801
Query: 714 RDSAD-LKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+ D + L++ + + + +Q+E ++ Q +K K + + + LK+ L
Sbjct: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
Query: 773 KLLREK 778
+ +E+
Sbjct: 1862 QDHKEQ 1867
Score = 80.9 bits (198), Expect = 4e-15
Identities = 128/572 (22%), Positives = 241/572 (42%), Gaps = 75/572 (13%)
Query: 159 SMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLE 218
S QE+ L Q LQEA + ++ EQ L Q D + +AL D+ L L+
Sbjct: 1774 SQREQEIVVLQQQLQEAREQGELKEQSL----------QSQLDEAQRALAQRDQELEALQ 1823
Query: 219 VMGNQLQACSKNQTEDSLRKELIALQ----------EDKHNYETTAKESLRRVLQEKIEV 268
Q Q E+ ++++ ALQ +++H KE RR+ +E
Sbjct: 1824 QEQQQAQG-----QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878
Query: 269 VRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQ 328
R++ +E L + E ++ Q++ E A ++ E + L D A+
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV---ETRALQDSWLQAQAVL 1935
Query: 329 EEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGD 388
+E Q+ +A + E Q +E+ +A+ EALQ + L ++HLL ++
Sbjct: 1936 KERDQELEALRAESQSS----RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
Query: 389 CTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDA 448
+ Q L ++ +EE +E + + ++ + + + ++ + D
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ--RDE 2049
Query: 449 QMDEQDLNEPLAKVSL---LKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFE 505
++ Q E L + SL +++++ + + ++E + +R +EL T QK E
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Query: 506 LQALLEEERKAY---------RNQVEESTKQIQVLQAQLQR-LHIDTENLREEKDSEITS 555
+ L E +++ + +EE + ++ L+ +LQR L LR+ + EI
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEW 2169
Query: 556 TRDELLSARDEILLLHQAAAKVAS-------------ERDTDIASLQEELKKVRAELERW 602
A+D L L Q A V+S ERD++ LQ+EL+ R LE+
Sbjct: 2170 RE----KAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Query: 603 RK----AASEYE-----KEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALE 653
R A S E ++ L + + D +++ R + LE L++ LE
Sbjct: 2226 RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR--LEHLQQAVARLE 2283
Query: 654 TECHSLKRENVLLSSELQRQEKELHNSQKQSL 685
+ L+R NV L S L++ E+E +++++
Sbjct: 2284 IDRSRLQRHNVQLRSTLEQVERERRKLKREAM 2315
Score = 75.9 bits (185), Expect = 1e-13
Identities = 157/707 (22%), Positives = 276/707 (39%), Gaps = 131/707 (18%)
Query: 176 LHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDS 235
L Q +Q+ ATL R L +A +++ E L RLE G + +N E +
Sbjct: 42 LKNSQEAQQRQATLVRKL----QAKVLQYRSWCQE--LEKRLEATGGPIPQRWENVEEPN 95
Query: 236 LRKELIALQEDKHNYETTAKESLR-RVLQEKIEVVRKL--SEVER---SLSNTEDEC--- 286
L + L+ L+E++ E+ A+ + + R+ EK +VV K +VE+ S DE
Sbjct: 96 LDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRK 155
Query: 287 ---------------------------------THLKEMNERTQEELRELANKYNGAVNE 313
H EM T +L EL ++
Sbjct: 156 ESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGS 215
Query: 314 IKDLSDKLKVAEGKQEEIQQKGQAEKKE------LQHKIDEMEEKEQELQAKIEALQADN 367
+ +L V + E G+ + +E L K E+E++ E ++ L++
Sbjct: 216 LLTCCLRLTVG-AQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQG 274
Query: 368 DF----TNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIV------------EGHLTKA 411
D +R+T L LL++S + I+ ++ + E L++
Sbjct: 275 DLEKAELQDRVTELSA-LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRN 333
Query: 412 VEETKLSKE------NQTRAKESD-FSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKV-S 463
+E KLS + Q +E D + D + +Q D QD ++ L V S
Sbjct: 334 AQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRS 393
Query: 464 LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEE 523
+L +Q +Q LR++L QE +Q+ EEE KA R ++++
Sbjct: 394 VL----------TRRRQAVQDLRQQLAGCQEAVNLLQQQ----HDQWEEEGKALRQRLQK 439
Query: 524 STKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAA-----AKVA 578
T + L Q L + ++L +E++ + R+EL R ++ +L Q A V
Sbjct: 440 LTGERDTLAGQTVDLQGEVDSLSKEREL-LQKAREEL---RQQLEVLEQEAWRLRRVNVE 495
Query: 579 SERDTDIA-----SLQEELKKVRAELERWRK-------AASEYEKEITSLQNSFQLRCQQ 626
+ D A QEEL E ER ++ SE E+ +L+ + + +
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE 555
Query: 627 CE--DQQREEAT----RLQGELEKLRKEWNALETECHSLKRENVLLS--SELQRQEKELH 678
E Q++ E T R + + +L N L+TE L+ V LS +E +K
Sbjct: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGL 615
Query: 679 NSQKQSLE-----LTSDLSILQMSRKELENQVGSL---KEQHLRDSADLKTLLSKAENQA 730
N Q LE + S + + +R L+ + +E + L+ L KAE
Sbjct: 616 NQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
++Q + Q E++ K + ++++ T +L+Q K E
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722
Score = 75.9 bits (185), Expect = 1e-13
Identities = 126/599 (21%), Positives = 261/599 (43%), Gaps = 75/599 (12%)
Query: 209 DEDRLLSRLE-VMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIE 267
D D+ L+ + V+ + QA + + + +E + L + +H+ ++LR+ LQ+
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 268 VVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKV---- 323
L+ L D + +E+ ++ +EELR+ ++ ++ +L++
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDS 502
Query: 324 AEGKQEEIQQK---GQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEH 380
A+G++EE Q++ E++ LQ + +E K+ E +++ L+ + ++ L+
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH-----LEGE 557
Query: 381 LLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEK 440
LL + + T + ++ I E ++ +T+++ K S ++ L+ K
Sbjct: 558 LLRQEQTEVTAA---LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 441 SSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSK 500
+ + + Q + + ++ LQ +E E ++E + +EAQ + ++
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ--LQKAE 672
Query: 501 QKCFELQALL---EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTR 557
+ ELQA L +EE++ + ++ ES Q + QL++LH + + +EE + +
Sbjct: 673 EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR-QEEVLARAVQEK 731
Query: 558 DELLSARDEILLLHQAAAKVASERDT-DIASLQEELKKVRAELERWRKAASEYEKEITSL 616
+ L+ + + + QA ERD D+A + L + LE A + I
Sbjct: 732 EALVREKAALEVRLQAV-----ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786
Query: 617 QNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQR---- 672
+ +++ Q Q +E +QGE+ L+ E L+TE ++E + +L +
Sbjct: 787 KGQLEVQIQTVT--QAKEV--IQGEVRCLKLE---LDTERSQAEQERDAAARQLAQAEQE 839
Query: 673 ------QEKELHNSQKQSL-------------ELTSDLSILQMSRKELENQVGSLKEQHL 713
Q+K H + L EL L L+ + ELE + LKEQ
Sbjct: 840 GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMR---LKEQ-- 894
Query: 714 RDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+ E +A Q+E E+TQ + +++ E TE+E+ S+ + L Q + L
Sbjct: 895 -----------QTEMEAIQAQREEERTQAESALCQMQLE-TEKERVSLLETLLQTQKEL 941
Score = 72.8 bits (177), Expect = 1e-12
Identities = 130/608 (21%), Positives = 237/608 (38%), Gaps = 67/608 (11%)
Query: 236 LRKELIALQEDKHNYETTAKESLRR---VLQEKIEVVRKLS-----------EVERSLSN 281
L ++++ALQ+ + + L+ Q + +VRKL E+E+ L
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 282 TEDECTHLKE-MNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
T E + E +EL + + +++ +L++ K + + + A ++
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK---ALRE 136
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
+++ + EL K Q + +F L LLS TF F+E K
Sbjct: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE-MK 195
Query: 401 KLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLA 460
+ E +LS T + S+E + D + EP
Sbjct: 196 SATDRDLMELKAEHVRLSGSLLTCCLRLTVG---AQSREPNGSGRMDGR-------EPAQ 245
Query: 461 KVSLLKDDLQGAQSEIEAKQEIQHLRKEL-IEAQELARTSKQKCFELQALLEEERKAYRN 519
+ LL + + E QE+ L+ + +E EL + + EL ALL + +K
Sbjct: 246 LLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAEL----QDRVTELSALLTQSQK---- 297
Query: 520 QVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVAS 579
Q E+ K I+ L+ ++ L + L E + S + ++E LS + I + Q +
Sbjct: 298 QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGD 357
Query: 580 ------------ERDTDIAS------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQ 621
E D+ I S + L VR+ L R R+A + +++ Q +
Sbjct: 358 NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVN 417
Query: 622 LRCQQCEDQQREEATRLQGELEKLRKEWNA-------LETECHSLKRENVLLSSELQRQE 674
L QQ DQ EE L+ L+KL E + L+ E SL +E LL +
Sbjct: 418 L-LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR 476
Query: 675 KELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQ-HL--RDSADLKTLLSKAENQAK 731
++L ++++ L LQ+ + Q +E+ HL R+ L+ +L E +
Sbjct: 477 QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS 536
Query: 732 DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLA 791
+ E + L L+ E+ QE+ +T L + + ++ L N + A
Sbjct: 537 ESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRA 596
Query: 792 ALVAVTAI 799
A V ++A+
Sbjct: 597 AAVKLSAL 604
Score = 64.7 bits (156), Expect = 3e-10
Identities = 118/529 (22%), Positives = 223/529 (42%), Gaps = 100/529 (18%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGN 222
QEL L Q + H+E+ + LQ L A Q L+++ L LE
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 223 QLQA------CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSE-- 274
LQA Q E++LR + +Q+ Y+ ++ L++ L ++ E +R E
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ-LQQALAQRDEELRHQQERE 2058
Query: 275 --VERSLSNTEDECTHLKEMN---ERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQE 329
+E+SL+ E ++ N ER +EE+R L + +V E+ +L +A+ +QE
Sbjct: 2059 QLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL----HQSVREL-----QLTLAQKEQE 2109
Query: 330 -----EIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSK 384
E QQ+ E HK MEE+ +L + LQ + ERL A
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE----LERLQA-------- 2157
Query: 385 SGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDD 444
A+ +T+ ++E + R K D + +L+ +K S
Sbjct: 2158 --------------------------ALRQTE-AREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 445 TTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ--K 502
A + + E ++ L+D+L+ + +E K+ + EL +Q +
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALE-KERLH--SPGATSTAELGSRGEQGVQ 2247
Query: 503 CFELQALLEE------ERKAYRNQVE---ESTKQIQVLQAQLQRLHIDTENLREEKDSEI 553
E+ + E E++++R ++E ++ ++++ +++LQR ++ + E+ + E
Sbjct: 2248 LGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER 2307
Query: 554 TS-TRDELLSARDEILLLHQAAAKVASERD---------TDIASLQEELKKVRAELERWR 603
R+ + +A+ L + +A A +++D +A LQ+E+ ++A+L R
Sbjct: 2308 RKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLER 2367
Query: 604 KAASEY-------EKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKL 645
K +Y +E+ L +S L Q EAT L+ E +L
Sbjct: 2368 KQKQDYITRSAQTSRELAGLHHS--LSHSLLAVAQAPEATVLEAETRRL 2414
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 105 bits (261), Expect = 2e-22
Identities = 131/565 (23%), Positives = 252/565 (44%), Gaps = 53/565 (9%)
Query: 229 KNQTEDSLRKELIALQEDKHNYETTAK---------ESLRRVLQEKIEVVRKLSEVERSL 279
K TE LR++ LQE++ E K E + L+E I+ + L + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNA- 178
Query: 280 SNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEK 339
T C LKE R+ E+ ++ + DL++ ++ EE++ + + +
Sbjct: 179 --TRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSR 236
Query: 340 KELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQ 399
E+ K+ E EK Q L+ E + ND E+ +L + Q E +
Sbjct: 237 LEMHFKLKEDYEKIQHLEQ--EYKKEIND--KEKQVSL-------------LLIQITEKE 279
Query: 400 KKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPL 459
K+ LT +EE++ K NQ K S+ L S EK T + + + L +
Sbjct: 280 NKM---KDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSV 335
Query: 460 AKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQAL-LEEERKAYR 518
+ L++DLQ A I E + + E A + FE LEE + +
Sbjct: 336 STQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ 395
Query: 519 NQVEESTKQIQVLQAQLQRLHIDTE---NLREEKDSEITSTRDELLSARDEILLLHQAAA 575
++E++ Q+++L +LQ+ + E L K+ E+ + ++L ++ +L ++
Sbjct: 396 QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK-KVLGEKETLLYENKQFE 454
Query: 576 KVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQRE-E 634
K+A E + ++EL + L+ K + E ++T++ S Q ++ +D + E E
Sbjct: 455 KIAEE----LKGTEQELIGL---LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELE 507
Query: 635 ATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSIL 694
+L+ +L N L E L +E ++ EL+ Q+++++N++KQ + + L
Sbjct: 508 NEKLKN--TELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565
Query: 695 QMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELK-----L 749
Q + +L N++ ++E+ + ++K L K+E +++K+ E + EL+ L
Sbjct: 566 QETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKAL 625
Query: 750 KFEMTEQEKQSITDELKQCKNNLKL 774
K + T + KQ E+K K L+L
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELEL 650
Score = 68.2 bits (165), Expect = 3e-11
Identities = 104/553 (18%), Positives = 230/553 (41%), Gaps = 76/553 (13%)
Query: 228 SKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECT 287
S+ + L+++ +Q + Y+ + ++V I++ K ++++ E+
Sbjct: 235 SRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 294
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
+ ++ E+T+ + S+ LK + KQ + ++ + K LQ +
Sbjct: 295 KVNQLEEKTKLQ------------------SENLKQSIEKQHHLTKELEDIKVSLQRSVS 336
Query: 348 EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH 407
+ E++LQ A + T E+ T ++E +++ H F+ + E
Sbjct: 337 TQKALEEDLQI---ATKTICQLTEEKETQMEESNKARAA------HSFV------VTEFE 381
Query: 408 LTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKD 467
T E L E Q K D L+ +K S + E + K++ K+
Sbjct: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL-----------EEMTKLTNNKE 430
Query: 468 -DLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTK 526
+L+ + + K+ + + K+ + E + ++Q+ L E+E Q+ T
Sbjct: 431 VELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITT 490
Query: 527 QIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIA 586
Q +++ L + EN + K++E+TS ++L E+ + S+ ++
Sbjct: 491 SEQYYSKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKEL-------TQETSDMTLELK 542
Query: 587 SLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCE----------DQQREEAT 636
+ QE++ + + ER K ++ T L+N + ++ + D+ E
Sbjct: 543 NQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCN 602
Query: 637 RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDL----S 692
L+ ++E K L+ E +LK++ S +L E +++ K LEL S
Sbjct: 603 NLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN---KLELELESAKQKFGE 659
Query: 693 ILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK-TQTVLSELKLKF 751
I +KE+E++ + E++L + + +++ ++A +QKE +K Q ++E+
Sbjct: 660 ITDTYQKEIEDK--KISEENLLEEVEKAKVIA---DEAVKLQKEIDKRCQHKIAEMVALM 714
Query: 752 EMTEQEKQSITDE 764
E + + I +E
Sbjct: 715 EKHKHQYDKIIEE 727
Score = 63.5 bits (153), Expect = 7e-10
Identities = 79/371 (21%), Positives = 155/371 (41%), Gaps = 47/371 (12%)
Query: 232 TEDSLRKELIALQEDKHNYET--TAKESLRRVLQEKIEVVRKLSEVERSLSNTE--DECT 287
TE L L A +++ H+ E TA + + ++++ ++ E E+ L NTE C
Sbjct: 463 TEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEK-LKNTELTSHCN 521
Query: 288 HL----KEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQ 343
L KE+ + T + EL N+ N K LK E QE Q
Sbjct: 522 KLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLR-------- 573
Query: 344 HKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLI 403
+E+E +EL+ K + ++ D + E L++ + +K+ +I + + K L
Sbjct: 574 ---NELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKN----KYIEELQQENKALK 626
Query: 404 VEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS 463
+G K N+ + + + D ++ E++L E + K
Sbjct: 627 KKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK 686
Query: 464 LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEE 523
++ D+ Q EI+ + QH K E+ AL+E+ + Y +EE
Sbjct: 687 VIADEAVKLQKEID--KRCQH-----------------KIAEMVALMEKHKHQYDKIIEE 727
Query: 524 STKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDT 583
++ + +++ Q + +LR + E+++ + ELLS + ++ + + K+ E
Sbjct: 728 RDSELGLYKSKEQ----EQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 584 DIASLQEELKK 594
+ A+L+E+ K
Sbjct: 784 NTATLKEKKDK 794
Score = 54.7 bits (130), Expect = 3e-07
Identities = 132/623 (21%), Positives = 252/623 (40%), Gaps = 70/623 (11%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQAC 227
L Q +++ H + LE +LQR S Q ++ED ++ + QL
Sbjct: 310 LKQSIEKQHHLTKELEDIKVSLQR---------SVSTQKALEEDLQIATKTIC--QLTEE 358
Query: 228 SKNQTEDSLRKELIALQEDKHNYETT--AKESLRRVLQEKIEVVR---KLSEVERSLSNT 282
+ Q E+S K A +ETT + E L R Q+++E K+ +E ++
Sbjct: 359 KETQMEES-NKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSS 417
Query: 283 E-DECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKE 341
E +E T L E EEL+++ + + E K + +G ++E+ QA +KE
Sbjct: 418 ELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKE 477
Query: 342 ---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHL--LSKSGGDCTFIHQFI 396
L+ ++ + EQ +++ L+ + + + T L H LS + T +
Sbjct: 478 VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDM 537
Query: 397 ECQKKLIVEG-HLTKAVEETKLSKENQTRAKESDFSDTLSPSKE--KSSDDTTDAQMDEQ 453
+ K E + K EE L + + E+ + L +E K D ++D+
Sbjct: 538 TLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKS 597
Query: 454 DLNEPLAKVSLLKDDLQGAQSEIEA-KQEIQHLRKELIEAQELARTSKQKCFELQA-LLE 511
+ N + L+ ++ IE +QE + L+K + A + + +E++ LE
Sbjct: 598 EEN-----CNNLRKQVENKNKYIEELQQENKALKK-----KGTAESKQLNVYEIKVNKLE 647
Query: 512 EERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLH 571
E ++ + + E T Q +++ I ENL EE ++ DE + L
Sbjct: 648 LELESAKQKFGEIT---DTYQKEIEDKKISEENLLEEV--------EKAKVIADEAVKLQ 696
Query: 572 QAAAKVASERDTDIASLQEELK----KVRAELERWRKAASEYEKEITSLQNSFQLRCQQC 627
+ K + ++ +L E+ K K+ E + E+E +SL+ S ++
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI----- 751
Query: 628 EDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL-QRQEKELHNSQKQSLE 686
E + L+ EL ++K+ E LKRE ++ L ++++K+ ++ E
Sbjct: 752 ------ELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
Query: 687 LTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSE 746
+ L + + + S+ +D D L + A+N + K TV +
Sbjct: 806 IYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY--LWTSAKN---TLSTPLPKAYTVKTP 860
Query: 747 LKLKFEMTEQEKQSITDELKQCK 769
K K + E I + K+ K
Sbjct: 861 TKPKLQQRENLNIPIEESKKKRK 883
Score = 44.3 bits (103), Expect = 5e-04
Identities = 69/343 (20%), Positives = 135/343 (39%), Gaps = 47/343 (13%)
Query: 161 YSQELFQLSQYLQ-EALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEV 219
YS+E+ L L+ E L ++ +TQE SD + LE+
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMT-------------LEL 541
Query: 220 MGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSL 279
Q + + E+ + K++ LQE + + + Q++ EV KL + E +
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 280 SNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEK 339
+N + + + E Q+E + L K ++ K+ E + E +QK
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 340 KELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQ 399
Q +I++ + E+ L ++E + D LQ+ + + CQ
Sbjct: 662 DTYQKEIEDKKISEENLLEEVEKAKVIAD----EAVKLQKEIDKR-------------CQ 704
Query: 400 KKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPL 459
K+ + +E+ K + ++S+ S +E+SS A ++
Sbjct: 705 HKI---AEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSS---LRASLE-------- 750
Query: 460 AKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQK 502
++S LK +L + ++E ++E + K EA+E T K+K
Sbjct: 751 IELSNLKAELLSVKKQLEIEREEKEKLKR--EAKENTATLKEK 791
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 104 bits (260), Expect = 3e-22
Identities = 144/656 (21%), Positives = 309/656 (47%), Gaps = 91/656 (13%)
Query: 187 ATLQRLLAITQEASDTSWQAL-IDEDRLLSRLEV------MGN---QLQACSKNQTED-- 234
A +RL A+ E ++T Q L + ++ + + EV MG+ +L+ N ++
Sbjct: 73 ALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIE 132
Query: 235 SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNE 294
+L+ EL+A++ K++ + K +L++ L+E + +LSE + +N+ED L+E E
Sbjct: 133 NLKNELMAVRS-KYSED---KANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 295 RT----QEELRELANKYNGAVNEIKDLSDKLK-VAEGKQEEIQQKGQAEKKELQHKIDEM 349
+ +E++ L + + +E K+ +L+ + E + Q+ + ++EL
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 350 EEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLT 409
+E+ +EL +IEA +++ +L L+E+L+ + I + EC+ + +L
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE-----NLR 303
Query: 410 KAVEETKLSKENQTRA---KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLK 466
KA + +++NQ + +E+ F + + K K +DT L E ++ S+LK
Sbjct: 304 KAT--SNANQDNQICSILLQENTFVEQVVNEKVKHLEDT---------LKELESQHSILK 352
Query: 467 DDLQGAQS-EIEAKQEIQHLRKELIEAQE---------LARTSKQKCF--ELQALLEEER 514
D++ + +++ + + QH++ E +E L +Q C +L++ L
Sbjct: 353 DEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
Query: 515 KAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAA 574
K + VE+ +++Q L+ Q Q+ + E ++ ++ + E L+ EI L +
Sbjct: 413 KQFCYTVEQHNREVQSLKEQHQK------EISELNETFLSDSEKEKLTLMFEIQGLKEQC 466
Query: 575 AKVASERDTDI---ASLQEELKKVRAEL-ERWRKAASEYE-------KEITSLQNSFQLR 623
+ E+ I SL+E ++ ++ EL E K + E+E ++ LQ +
Sbjct: 467 ENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTA 526
Query: 624 CQQCEDQQREEATRLQGELEKLRKEWN---ALETECHSLKRENVLLSSELQRQEKELHNS 680
+ +D E RLQGE EKL + LE +L+ +N + L +++ L
Sbjct: 527 FTE-KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKEL 585
Query: 681 QKQSLELTSD----LSILQMSRKELEN-------------QVGSLKEQHLRDSADLKTLL 723
+ + LT + ++ L+ S +E++N ++G EQ ++ +++L+ +
Sbjct: 586 EGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 645
Query: 724 SKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQC-KNNLKLLREK 778
++ ++ KE ++ L +L ++ ++ ++K+ ++ E+K + N KL EK
Sbjct: 646 NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEK 701
Score = 95.1 bits (235), Expect = 2e-19
Identities = 133/612 (21%), Positives = 274/612 (44%), Gaps = 53/612 (8%)
Query: 171 YLQEALHREQMLEQK-LATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSK 229
+++E + + +LEQK L + L + +++ S D + LE L+ K
Sbjct: 902 FIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECK 961
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVR----KLSEVERSLSNTEDE 285
+ E + +L+A++ K +++ KE+ + ++E++E +R +LS R L +
Sbjct: 962 EKEEKINKIKLVAVKAKKE-LDSSRKET--QTVKEELESLRSEKDQLSASMRDLIQGAES 1018
Query: 286 CTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHK 345
+L E+ E+L + N + I+DL+ +L+ + + E I ++ ++L +
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETIN----SDNEDLLAR 1074
Query: 346 IDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVE 405
I+ ++ + L+ +I +Q ++ L A + K T +++ E Q +L E
Sbjct: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKE 1134
Query: 406 G-HLTKAVEETKLSKENQTRA-----KESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPL 459
L K ++E +L K++ + + +D+ + +K ++ + EQ++
Sbjct: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 460 AKVSLLKDDLQGAQSEIEAKQEIQHLRKELI--EAQELARTSKQKCFEL--QALLEEERK 515
K L++++ QS ++ +E K+L+ +ELA + + + L QA L+ E +
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE 1254
Query: 516 AYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAA 575
A + QVE Q+ + ++ ++H + E+ +++ + + + ++E A
Sbjct: 1255 ASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQA 1314
Query: 576 KVASERDT------DIASLQEELKKVRAELERWRKAASEYEKEITSL-------QNSFQL 622
V SE ++ ++ Q+ +AE E ++ E I L QN+ Q+
Sbjct: 1315 TVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQI 1374
Query: 623 RCQQCEDQQREEATRLQGELEKLR----KEWNALETECHSLKRENVLLSSELQRQEKELH 678
+ + Q E T L+ + L+ KE E C S++ EN+++ SE
Sbjct: 1375 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLC-SIQSENMMMKSE--------- 1424
Query: 679 NSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYE 738
++Q S +LTS +L R +QV L+E+H + L+ LSK E Q ++ E
Sbjct: 1425 HTQTVS-QLTSQNEVL---RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPT 1480
Query: 739 KTQTVLSELKLK 750
V S+ LK
Sbjct: 1481 TRSPVSSQQSLK 1492
Score = 94.0 bits (232), Expect = 5e-19
Identities = 151/705 (21%), Positives = 302/705 (42%), Gaps = 117/705 (16%)
Query: 172 LQEALHREQMLEQKLATLQRLLAITQE-ASDTSWQALIDEDRLLSRLEVMGNQLQ----- 225
L + L EQ+ QKL +L +E S+ S + +E +++ L+ +G L
Sbjct: 741 LNKLLENEQV--QKLFVKTQLYGFLKEMGSEVSEDS--EEKDVVNVLQAVGESLAKINEE 796
Query: 226 ----ACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSN 281
A +++ L KE+ LQE+ K LR QEK+ + ++L E++
Sbjct: 797 KCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEA 856
Query: 282 TEDECTHLKEMNERTQ----------EELRELANKYN----------------GAVNEIK 315
+ + +K NE+T+ EE+ + +K + E K
Sbjct: 857 LQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK 916
Query: 316 DLSDK------LKVAEGKQEEIQQKGQAEKKELQHKIDEME----EKEQEL-QAKIEALQ 364
+L D+ LK + K ++ + KEL+ KI+ +E EKE+++ + K+ A++
Sbjct: 917 ELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVK 976
Query: 365 ADNDFTNER--LTALQEHLLS------KSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK 416
A + + R ++E L S + + Q E K L++E + +
Sbjct: 977 AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE 1036
Query: 417 LSKENQTRAKESDFSDTLSPSK---EKSSDDTTD--AQMDEQDLNEPLAKVSLLKDDLQG 471
+ N + D + L S E + D D A+++ N L +V +L ++Q
Sbjct: 1037 KERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL--EVQR 1094
Query: 472 AQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVL 531
A++ ++ + E + L+KE + +E A T+ + ELQ L++E+K Q++++ ++++++
Sbjct: 1095 AKAMVDKELEAEKLQKEQ-KIKEHA-TTVNELEELQVQLQKEKK----QLQKTMQELELV 1148
Query: 532 QAQLQRLHI------DTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDI 585
+ Q+ + D E L +E + ++T+ +++ EI + Q + E +
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQ 1208
Query: 586 ASLQEE----------LKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCE------- 628
+S+Q+ L K + EL ++A +++ SL+ + QQ E
Sbjct: 1209 SSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLA 1268
Query: 629 ----------DQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELH 678
+ + A + Q L ++ AL+ EC + K E ++SE + + +H
Sbjct: 1269 EITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVH 1328
Query: 679 N---SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDS--------ADLKTLLSKAE 727
N QK ++ + R+ LE + LK + L+DS ++L+TL S+ +
Sbjct: 1329 NVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIK-LQDSQNNLQINVSELQTLQSEHD 1387
Query: 728 NQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
+ K ++T + +EL+ K + E + E Q + L
Sbjct: 1388 TLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1432
Score = 68.2 bits (165), Expect = 3e-11
Identities = 99/462 (21%), Positives = 183/462 (39%), Gaps = 72/462 (15%)
Query: 319 DKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQ 378
D +K A+ KQ + QK ++ EL+ +I+E+ K + T + + AL
Sbjct: 29 DLIKFAK-KQMMLIQKAKSRCTELEKEIEELRSKPV------------TEGTGDIIKALT 75
Query: 379 EHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL--SP 436
E L L++E T+ + L KEN +E + S T
Sbjct: 76 ERL------------------DALLLEKAETEQ-QCLSLKKENIKMKQEVEDSVTKMGDA 116
Query: 437 SKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELA 496
KE + E NE +A S +D Q ++E E + + EL E +
Sbjct: 117 HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLE---EAMNTQLELSEQLKFQ 173
Query: 497 RTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEK----DSE 552
S+ +LQ +E+ R + Q+ KQ+ + + +N+ E
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN 233
Query: 553 ITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKE 612
I S ++ELL + A QEE+K++ ++E +A E+E E
Sbjct: 234 INSLQEELLQLK---------------------AIHQEEVKELMCQIE---ASAKEHEAE 269
Query: 613 ITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETE---CHSLKRENVLLSSE 669
I L + +QCE ++ + + ELE LRK + + C L +EN +
Sbjct: 270 INKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQV 329
Query: 670 LQRQEKELHNSQK----QSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSK 725
+ + K L ++ K Q L +++ + + +LE +K++ + DL+ +++
Sbjct: 330 VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 389
Query: 726 AENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQ 767
++ EK ++ L+ L +F T ++ LK+
Sbjct: 390 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 431
Score = 59.7 bits (143), Expect = 1e-08
Identities = 95/391 (24%), Positives = 164/391 (41%), Gaps = 72/391 (18%)
Query: 435 SPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLR-------- 486
+P KS +T + ++DL + K +L + +E+E +EI+ LR
Sbjct: 14 TPGTGKSKLET----LPKEDLIKFAKKQMMLIQKAKSRCTELE--KEIEELRSKPVTEGT 67
Query: 487 ----KELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHI-- 540
K L E + K + + L++E + +VE+S ++ +L++ HI
Sbjct: 68 GDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINY 127
Query: 541 --DTENLREE------KDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEEL 592
+ ENL+ E K SE + + L L K + + ++ LQEE+
Sbjct: 128 VKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEI 187
Query: 593 KKVR-------AELERWRKAASEYEKE-ITSLQ--------------NSFQLRCQQCEDQ 630
+K+R L++ A ++ +KE +T LQ NS Q Q +
Sbjct: 188 EKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAI 247
Query: 631 QREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL------QRQEKELHNSQKQS 684
+EE L ++E KE A + + LK EN++ E ++ E EL N +K +
Sbjct: 248 HQEEVKELMCQIEASAKEHEAEINKLNELK-ENLVKQCEASEKNIQKKYECELENLRKAT 306
Query: 685 LELTSDLSILQMSRKE--LENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQT 742
D I + +E QV + K +HL D+ L + E+Q ++ E T
Sbjct: 307 SNANQDNQICSILLQENTFVEQVVNEKVKHLEDT------LKELESQHSILKDEV----T 356
Query: 743 VLSELKLKFEMTEQEKQSITDELKQCKNNLK 773
++ LKLK EM + Q I DE + +L+
Sbjct: 357 YMNNLKLKLEM---DAQHIKDEFFHEREDLE 384
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 104 bits (260), Expect = 3e-22
Identities = 127/588 (21%), Positives = 260/588 (44%), Gaps = 73/588 (12%)
Query: 224 LQACSKNQTEDSLRKELIALQEDKHNYETTAKE---SLRRVLQEKIEVVRKLSEVERSLS 280
L++ + + S+++E L+E E KE + +LQEK ++ ++ + +L+
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 281 NTEDECTHL-----------KEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQE 329
+ E+ C L KEMNER ++E E+ + +++D +LK E
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 330 EIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
K + EK ++K+ + E+ L I L + E + L ++
Sbjct: 959 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018
Query: 390 TFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQ 449
T ++ ++++ L ++E+ K + + RAK L + + + D +
Sbjct: 1019 TLTKAKVKLEQQV---DDLEGSLEQEKKVRMDLERAKRK-----LEGDLKLTQESIMDLE 1070
Query: 450 MDEQDLNEPLAK-------VSLLKDDLQGAQSEIEAK-QEIQHLRKELIEAQELARTSKQ 501
D+Q L+E L K ++ +D Q S+++ K +E+Q +EL E E RT++
Sbjct: 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA 1130
Query: 502 KCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL 561
K +L++ L E + ++EE+ V Q++ + +++++E R +L
Sbjct: 1131 KVEKLRSDLSRELEEISERLEEAGGATSV---QIE--------MNKKREAEFQKMRRDL- 1178
Query: 562 SARDEILLLHQAAAKVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSLQN-- 618
+E L H+A A ++ D +A L E++ ++ ++ K SE++ E+ + +
Sbjct: 1179 ---EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235
Query: 619 --------SFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL 670
+ + C+ EDQ E + + E+ ++ N L ++ L+ EN LS +L
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEH----RSKAEETQRSVNDLTSQRAKLQTENGELSRQL 1291
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKE-----QHLRDSADLKTLLSK 725
+E + + L T L L +++LE +V + Q R DL +
Sbjct: 1292 DEKEALISQLTRGKLTYTQQLEDL---KRQLEEEVKAKNALAHALQSARHDCDLLREQYE 1348
Query: 726 AENQAK-DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
E +AK ++Q+ K + +++ + K+E ++ T+EL++ K L
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQR---TEELEEAKKKL 1393
Score = 102 bits (254), Expect = 1e-21
Identities = 152/668 (22%), Positives = 276/668 (41%), Gaps = 113/668 (16%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D ++++L LQ + +D +
Sbjct: 957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD------L 1010
Query: 242 ALQEDKHNYETTAKESLRRV---LQEKIEVVRKLS-EVERSLSNTEDECTHLKEMNERTQ 297
+EDK N T AK L + L+ +E +K+ ++ER+ E + + TQ
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL-------KLTQ 1063
Query: 298 EELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKG---QAEKKELQHKIDEMEEK-- 352
E + +L N +K +L + E+ Q G Q + KELQ +I+E+EE+
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 353 -EQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH-LTK 410
E+ +AK+E L++D + L + E L + G T + IE KK E + +
Sbjct: 1124 AERTARAKVEKLRSD---LSRELEEISERL--EEAGGATSVQ--IEMNKKREAEFQKMRR 1176
Query: 411 AVEETKLSKENQTRAKESDFSDT----------LSPSKEKSSDDTTDAQMDEQDLNEPL- 459
+EE L E A +D+ L K+K + ++ +++ D+ +
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 460 ----AKVSL------LKDDLQGAQSEIEAKQ---------------EIQHLRKELIEAQE 494
AK +L L+D + +S+ E Q E L ++L E +
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA 1296
Query: 495 LAR-------TSKQKCFELQALLEEERKA-----------------YRNQVEESTKQIQV 530
L T Q+ +L+ LEEE KA R Q EE T+
Sbjct: 1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE 1356
Query: 531 LQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASL-- 588
LQ L + + + R + +++ +EL A+ ++ Q A + + +SL
Sbjct: 1357 LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK 1416
Query: 589 -----QEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELE 643
Q E++ + ++ER AA+ +K+ Q +F + + + E Q ELE
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALDKK----QRNFDKILAEWKQKYEES----QSELE 1468
Query: 644 KLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELEN 703
+KE +L TE LK L+ ++E N Q++ +LT L + ELE
Sbjct: 1469 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE- 1527
Query: 704 QVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITD 763
+++Q + +L++ L +AE + + + + Q +++K + E EK +
Sbjct: 1528 ---KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD---E 1581
Query: 764 ELKQCKNN 771
E++Q K N
Sbjct: 1582 EMEQAKRN 1589
Score = 100 bits (250), Expect = 4e-21
Identities = 137/649 (21%), Positives = 278/649 (42%), Gaps = 92/649 (14%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
Y+Q+L L + L+E + + L L + + + +E + +A + R+LS+
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
Q + YET A + + + K ++ ++L E E ++
Sbjct: 1368 VAQWRT----------------------KYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C+ L++ R Q E+ +L +N A+++ + DK+ +AE KQ EE Q
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI-LAEWKQKYEESQ 1464
Query: 333 ---QKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ Q E + L ++ +++ +E +E + +N E ++ L E L G
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL----GSSG 1520
Query: 390 TFIHQFIECQKKLIVEG-HLTKAVEETKLS---KENQTRAKESDFSDTLSPSKEKSSDDT 445
IH+ + +K+L E L A+EE + S +E + + +F+ + + K ++
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK- 1579
Query: 446 TDAQMDEQDLNEPLAKVSLLKDDLQG-AQSEIEAKQ-------EIQHLRKELIEAQELAR 497
D +M++ N L V L+ L +S EA + ++ + +L A +A
Sbjct: 1580 -DEEMEQAKRNH-LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Query: 498 TSKQKCFELQALLEEERKAYRNQV---EESTKQIQVLQAQLQRLHIDTENLR---EEKDS 551
++++ LQ+LL++ + + V ++ + I +++ + L + E LR E+ +
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697
Query: 552 EITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAASE 608
EL+ + + LLH + +++ D D++ LQ E+++ ++ R A +
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA---VQECRNAEEK 1754
Query: 609 YEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL---- 659
+K IT E+ ++E+ T R++ +E+ K+ E +
Sbjct: 1755 AKKAITDA-------AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 660 -KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKEL-----ENQVGSLKEQHL 713
K++ L + ++ E EL QK++ E + + KEL E++ L+ Q L
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDL 1867
Query: 714 RDSADLKTLLSK-----AENQAKDVQKEYEKTQTVLSELKLKFEMTEQE 757
D LK K AE QA ++ K Q L E + + ++ E +
Sbjct: 1868 VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1916
Score = 83.6 bits (205), Expect = 7e-16
Identities = 148/677 (21%), Positives = 272/677 (40%), Gaps = 119/677 (17%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEA-SDTSWQALIDEDRLLSRLEVMGN--- 222
QL + L+E R + LE++L + A ++ SD S + + + RLE G
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL----EEISERLEEAGGATS 1158
Query: 223 -QLQACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
Q++ K + E +R++L +E +E TA ++ E+ ++ ++R
Sbjct: 1159 VQIEMNKKREAEFQKMRRDL---EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1215
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQ------- 333
E E + K + + ++ + L D++ K EE Q+
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1275
Query: 334 ---KGQAEKKELQHKIDEMEEKEQEL-QAKIEALQADNDFTNERLTALQE-----HLLSK 384
K Q E EL ++DE E +L + K+ Q D + ++ H L
Sbjct: 1276 QRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQS 1335
Query: 385 SGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKEN----QTRAK-ESDF---SDTLSP 436
+ DC + + E + + KA + LSK N Q R K E+D ++ L
Sbjct: 1336 ARHDCDLLREQYEEETE-------AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388
Query: 437 SKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIE--------AKQEIQHLRKE 488
+K+K + +A+ + +N AK S L+ Q+EIE + L K+
Sbjct: 1389 AKKKLAQRLQEAEEAVEAVN---AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Query: 489 LIEAQELARTSKQKCFELQALLEEERKAYR----------NQVEESTKQIQVLQAQLQRL 538
++ KQK E Q+ LE +K R N EES + ++ + + + L
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1505
Query: 539 HIDTENLREEKDS------EITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEEL 592
+ +L E+ S E+ R +L + + E+ + A + I Q E
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1565
Query: 593 KKVRAELER--------WRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEK 644
+++AE+ER +A + + + SLQ S E + R EA R++ +K
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLD-----AETRSRNEALRVK---KK 1617
Query: 645 LRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQ 704
+ + N +E + R +++E Q+Q K L S+L+ ++ +L++
Sbjct: 1618 MEGDLNEMEIQLSHANR----MAAEAQKQVKSLQ-------------SLLKDTQIQLDDA 1660
Query: 705 VGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE 764
V R + DLK ++ E + +Q E E EL+ E TE+ ++ E
Sbjct: 1661 V--------RANDDLKENIAIVERRNNLLQAELE-------ELRAVVEQTERSRKLAEQE 1705
Query: 765 LKQCKNNLKLLREKGNN 781
L + ++LL + +
Sbjct: 1706 LIETSERVQLLHSQNTS 1722
Score = 77.4 bits (189), Expect = 5e-14
Identities = 121/576 (21%), Positives = 248/576 (43%), Gaps = 64/576 (11%)
Query: 169 SQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS 228
++Y +A+ R + LE+ L + L +EA + + S LE ++LQ
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV-------NAKCSSLEKTKHRLQ--- 1422
Query: 229 KNQTEDSL------RKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNT 282
N+ ED + AL + + N++ E ++ + + E+ E RSLS
Sbjct: 1423 -NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEA-RSLST- 1479
Query: 283 EDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQ----EEIQQKGQAE 338
E LK E + E L + EI DL+++L + GK E+++++ +AE
Sbjct: 1480 --ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG-SSGKTIHELEKVRKQLEAE 1536
Query: 339 KKELQHKIDEME---EKEQ-----------ELQAKIEALQADNDFTNERLTA----LQEH 380
K ELQ ++E E E E+ +++A+IE A+ D E+ + +
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 381 LLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEK 440
L + + ++ + +KK+ EG L + E +LS N+ A+ +L +
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKM--EGDLNEM--EIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 441 SSDDTTDAQMDEQDLNEPLAKV----SLLKDDLQGAQSEIEAKQEIQHL-RKELIEAQE- 494
+ DA DL E +A V +LL+ +L+ ++ +E + + L +ELIE E
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 495 --LARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDS 551
L + + ++ + + +VEE+ ++ + + + ++ D + EE K
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1772
Query: 552 EITSTRDELLSARDEILL------LHQAAAKVASERDTDIASLQEELKKVRAELERWRKA 605
+ TS E + E + L +A + L+ ++++ ELE +K
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 606 ASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVL 665
+E K + + + Q E+ R+ RLQ ++KL+ + A + + + +
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEED-RKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1891
Query: 666 LSSELQRQEKELHNSQKQSLELTSDLSILQMSRKEL 701
S+ ++ + EL +++++ S ++ L+ +++
Sbjct: 1892 NLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Score = 62.8 bits (151), Expect = 1e-09
Identities = 55/227 (24%), Positives = 106/227 (46%), Gaps = 31/227 (13%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++ER+ ++AS++EE +++ LE+ E E+++ SL +N QL+ Q
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 626 ------------QCEDQQREEATRLQGELE---KLRKEWNALETECHSLKRENVLLSSEL 670
Q E + +E RL+ E E +L + LE EC LKR+ L L
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730
+ EKE H ++ + LT +++ L +L + +L+E H + DL+ E++
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA----EEDKV 1017
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+ K K + + +L+ E ++ + + ++ + +LKL +E
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Score = 44.7 bits (104), Expect = 4e-04
Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%)
Query: 107 VDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELF 166
V+ TE +RK+ ++ T + R ++H+ S + N +L
Sbjct: 1692 VEQTERSRKLAEQELIETSE-----------RVQLLHSQNTSLI-----NQKKKMDADLS 1735
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
QL ++EA+ + E+K AIT A + L E + LE M ++
Sbjct: 1736 QLQTEVEEAVQECRNAEEKAKK-----AITDAAMMA--EELKKEQDTSAHLERMKKNMEQ 1788
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDEC 286
K+ E IAL+ K + E+ R L+ ++E +K + S+
Sbjct: 1789 TIKDLQHRLDEAEQIALKGGKKQLQKL--EARVRELENELEAEQKRNA--ESVKGMRKSE 1844
Query: 287 THLKEMNERTQEELRELANKYNGAVNEIKDLSDKL--KVAEGKQEEIQQKGQAEK----- 339
+KE+ +T+E+ + L ++DL DKL KV K++ + + QA
Sbjct: 1845 RRIKELTYQTEEDRKNLLR--------LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 340 KELQHKIDEMEEKEQELQAKIEALQA 365
+++QH++DE EE+ ++++ L+A
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRA 1922
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 104 bits (260), Expect = 3e-22
Identities = 149/684 (21%), Positives = 295/684 (43%), Gaps = 107/684 (15%)
Query: 162 SQELF-QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
SQ+L L + L ++ + LE++L QRL ++ +D + QA D R + RL
Sbjct: 545 SQDLLGTLRKQLSDSESERRALEEQL---QRL----RDKTDGAMQAHEDAQREVQRLR-S 596
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYET--TAKESLRR----VLQEKIEVVRKLSE 274
N+L + K+ SL+ +E + E A+E LRR + +E+ + V+ +
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGAR 656
Query: 275 VERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQK 334
V R L ER+ +L +L K + E+ ++ + L A +++ +Q
Sbjct: 657 VRREL--------------ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-- 700
Query: 335 GQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNE---RLTALQEHLLSKSGGDCTF 391
AEK E+ + + E EL+ + L+A+ + +L+AL E L
Sbjct: 701 --AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRL 758
Query: 392 IHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLS------------PSKE 439
+ Q E +K ++G +A +E +++E Q R +E ++ ++E
Sbjct: 759 VAQLEE--EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Query: 440 KSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIE-----AKQEIQHLRKELIEAQE 494
+ + L E LA++S L G + E+E A+++++ L + E +
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQLSR---QLSGREQELEQARREAQRQVEALERAAREKEA 873
Query: 495 LARTSKQKCFELQALLEE-------------ERKAYRNQVEESTKQIQVLQAQLQRLHID 541
LA+ +L A E E++A + E +Q+ L+A+ ++L +
Sbjct: 874 LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Query: 542 TENL---REEKDSEITSTRDELLSARDEILLLHQAAAK--VASERDTDIASLQEELKKVR 596
+ L +E E+ R ++++ +++ L + A+ V +ER+ ASL+E+
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ-ASLREQRAAHE 992
Query: 597 AELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETEC 656
+L+R ++ +E+ + + Q + Q+ +Q E RL+ E E+L +E AL+ E
Sbjct: 993 EDLQRLQREKEAAWRELEAERAQLQSQLQR---EQEELLARLEAEKEELSEEIAALQQE- 1048
Query: 657 HSLKRENVLLSSELQRQEKELHNSQKQSL--ELTSDLSILQMSRKELENQVGSLKEQHLR 714
+ E +LL+ ++Q L S+K +L +L L E+E Q + + +
Sbjct: 1049 ---RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 715 DSADLKTLLS---------------------KAENQAKDVQKEYEKTQTVLSELKLKFEM 753
D + + L S + + QA+D+ K+ + EL+ + +
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRL 1165
Query: 754 TEQEKQSITDELKQCKNNLKLLRE 777
E + + EL + + L+ +E
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQE 1189
Score = 99.8 bits (247), Expect = 9e-21
Identities = 157/672 (23%), Positives = 279/672 (41%), Gaps = 111/672 (16%)
Query: 174 EALHRE-QMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQT 232
E HR+ + LE K + L + L +EA +A + D L + + L +
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALS---RATLQRDMLQAEKAEVAEALTKAEAGRV 718
Query: 233 E-----DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS------- 280
E LR E +LQ D + + ESL Q+K+++ R ++++E S
Sbjct: 719 ELELSMTKLRAEEASLQ-DSLSKLSALNESLA---QDKLDLNRLVAQLEEEKSALQGRQR 774
Query: 281 NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQA--- 337
E E T +E ER +E E G L L+VAE QE ++Q+
Sbjct: 775 QAEQEATVAREEQERLEELRLEQEVARQG-------LEGSLRVAEQAQEALEQQLPTLRH 827
Query: 338 EKKELQHKI-----------DEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSG 386
E+ +LQ ++ E+E+ +E Q ++EAL ER +E L +
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL--------ERAAREKEALAKEHA 879
Query: 387 GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTT 446
G Q + ++ EG T + E T+L E KE+ ++ + +
Sbjct: 880 G---LAVQLVAAER----EGR-TLSEEATRLRLE-----KEALEGSLFEVQRQLAQLEAR 926
Query: 447 DAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFEL 506
Q++ + LAK L +L G + +I A QE L KEL+ AQ+L + + E
Sbjct: 927 REQLEAEGQALLLAK-ETLTGELAGLRQQIIATQEKASLDKELM-AQKLVQAER----EA 980
Query: 507 QALLEEERKAYRNQVEESTKQIQV-----------LQAQLQRLHIDTENLREEKDSEITS 555
QA L E+R A+ ++ ++ + LQ+QLQR + E + E++
Sbjct: 981 QASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040
Query: 556 TRDELLSARDEILLLHQAAAKVA-SERDTDIASLQEELKKVR-------AELERWRKAAS 607
L RDE LLL ++ + A S ++++ +L E+L R E+ER ++ A
Sbjct: 1041 EIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ 1100
Query: 608 EYEKEITSLQNSFQLRCQQCEDQQRE-------EATRLQGELEKLRKEWNALETECHSLK 660
+++ S N+ + Q+ E E RLQ + L K+ ++ E L+
Sbjct: 1101 SRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELR 1160
Query: 661 RENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVG---SLKEQHLRDSA 717
+ LL +EL +Q++ E + + EL +G +E R +
Sbjct: 1161 TQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNE 1220
Query: 718 DLKTLLSKAENQAKDVQKEYEKTQTVLS--------------ELKLKFEMTEQEKQSITD 763
+L++ + KAE++ ++ E + L+ EL+ + E+ +
Sbjct: 1221 ELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR 1280
Query: 764 ELKQCKNNLKLL 775
EL++ + +K+L
Sbjct: 1281 ELQELRRQMKML 1292
Score = 93.2 bits (230), Expect = 9e-19
Identities = 149/634 (23%), Positives = 266/634 (41%), Gaps = 68/634 (10%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQAC 227
L Q L H L+++LA L R L+ ++ + QA + R + LE + +A
Sbjct: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE---QARREAQRQVEALERAAREKEAL 874
Query: 228 SKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEK------IEVVRKLSEVERSLSN 281
+K L +L+A + + T ++E+ R L+++ EV R+L+++E
Sbjct: 875 AKEHA--GLAVQLVAAEREGR---TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929
Query: 282 TEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKE 341
E E L E EL L + A E L +L + Q E + + ++
Sbjct: 930 LEAEGQALLLAKETLTGELAGLRQQII-ATQEKASLDKELMAQKLVQAEREAQASLREQR 988
Query: 342 LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKK 401
H+ ++++ ++E +A L+A+ +L QE LL++ + + + I ++
Sbjct: 989 AAHE-EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Query: 402 LIVEGHLTKAVEETK---LSKENQTRAKESDFSD-----TLSPSKEKSSDDTTDAQMDEQ 453
EG L E+ + L + +T E T+S E+ D Q EQ
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ--EQ 1105
Query: 454 DLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCF----ELQA- 508
D + A S L+D AQ E A Q +R+ +A++L + + C EL+
Sbjct: 1106 DRSTVNALTSELRD--LRAQREEAAAAHAQEVRRLQEQARDLGK-QRDSCLREAEELRTQ 1162
Query: 509 --LLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDE 566
LLE+ R R ++ E+ ++++ Q + + LR E R+ L + +E
Sbjct: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL-GEGAKEREALRRSNEE 1221
Query: 567 ILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI-TSLQNSFQLRCQ 625
L A K SER + E+ ++ A LE R A + E+ T LQ
Sbjct: 1222 ---LRSAVKKAESER-ISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV------ 1271
Query: 626 QCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSL 685
++ R EA R EL++LR++ L++E L RE L L E+ S++++L
Sbjct: 1272 ---ERSRLEARR---ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
Query: 686 ELTSDL-----------SILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQ---AK 731
L L LQ+++++L+ Q G + + R L+ + Q A+
Sbjct: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
Query: 732 DVQKEYEKTQTVLSELKLKFEMTEQEKQSITDEL 765
++ + E + +EL L+ E Q + EL
Sbjct: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
Score = 77.0 bits (188), Expect = 6e-14
Identities = 145/669 (21%), Positives = 271/669 (40%), Gaps = 65/669 (9%)
Query: 148 SPVDKVAANTPSMYSQELFQLSQYLQEALHR-EQMLEQKLATLQRLLAITQEASDTSWQA 206
SPV A S+ S L + +Q LQ+ L R E +L Q A L S+ QA
Sbjct: 64 SPVLLPATEMASLLS--LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA 121
Query: 207 LIDEDRLLSRLEVMGNQLQACSKN----QTEDSLRKELIALQEDKHNYETTAKESLRRVL 262
L E L E G Q+ + + S R++L A QE + + ++L
Sbjct: 122 LRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
Query: 263 QEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLK 322
Q K ++ SE+E+ L E L++ R E ++L + E + + +
Sbjct: 182 QYK----KRCSELEQQLLERSGE---LEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234
Query: 323 VAEGKQEEIQQKG---QAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQE 379
V +E++ Q G QA ++++ ++ +EL+ + A + + + N +
Sbjct: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294
Query: 380 HLLSKSGGDCTF------IHQFIECQKKLIVEGHL---TKAVEETKLSKENQTRAKESDF 430
LL F + F E + L + G L ++AV+E L R ES
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTE-RDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA 353
Query: 431 SDTLSPS---KEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRK 487
L + + + D + E+DL + + L K DL +E+ ++ L K
Sbjct: 354 EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLA--VKRLEK 411
Query: 488 ELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLRE 547
+ +E ++ + +K L++L +E+ A + E +Q L+ Q + D+E+ +
Sbjct: 412 QNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ--TLRDLAQAVLSDSESGVQ 469
Query: 548 EKDSEITSTRDE-----LLSARDEILLLHQAAAKVASER---------DTDIASLQEELK 593
SE T+ L R + + S R + +A + L
Sbjct: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
Query: 594 KVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQR---EEATRLQGELEKLRKEWN 650
K + +++ R YE L + + + E ++R E+ RL+ + + +
Sbjct: 530 KRQLQVQDMR---GRYEAS-QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
Query: 651 ALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKE 710
+ E L+ N LLS E L +Q+Q+ EL + LQ +++EL Q L+E
Sbjct: 586 DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645
Query: 711 QH---LRDSADLKTLLSKAENQAKDVQ-------KEYEKTQTVLSELKLKFEMTEQEKQS 760
+ ++D A ++ L ++ Q + ++ KE + + LS L+ +M + EK
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 761 ITDELKQCK 769
+ + L + +
Sbjct: 706 VAEALTKAE 714
Score = 77.0 bits (188), Expect = 6e-14
Identities = 103/518 (19%), Positives = 212/518 (40%), Gaps = 52/518 (10%)
Query: 267 EVVR-KLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAE 325
E VR L E + L + + E L+ +L E+ + + A + + L + +E
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 326 GKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIE---ALQADNDFTNERLTALQEHLL 382
+ + + + EL + + + E+E +A ++ L+ T L A QE +
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624
Query: 383 ------SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKE----NQTRAKESDFSD 432
+K GD + + ++ + V+ L + E +L + + A+ D
Sbjct: 1625 KMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQD 1684
Query: 433 TLSPSKEKSSDDTTDA---QMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKEL 489
+ + + +D A Q+ + LN LAKV +SE + +++ L + L
Sbjct: 1685 RVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE---------ESEGALRDKVRGLTEAL 1735
Query: 490 IEAQELARTSKQKCFELQA----------LLEEERKAYRNQVEESTKQIQVLQAQLQRLH 539
++ +++ K LQ +L+E A R + E+ KQ L Q+Q L
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
Query: 540 ---IDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELK 593
D E R E + ++ R+ L ++ K+ ER + SLQ L
Sbjct: 1796 GEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALA 1855
Query: 594 KVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALE 653
++ AE ++A EK+ +L+ + + ++ + + E+ RL E +L + E
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLD-KVEREKLRSHEDTVRLSAEKGRLDRTLTGAE 1914
Query: 654 TECHSLKRENVLLSSELQRQEKELH------NSQKQSLELTSDLSILQMSRKELENQVGS 707
E +R+ L +++ E+ ++Q+Q LEL ++ L+ ++ + E + +
Sbjct: 1915 LELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA 1974
Query: 708 LKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLS 745
+ H + L+ +S + Q +Q+E ++ S
Sbjct: 1975 RERAHRQRVRGLEEQVSTLKGQ---LQQELRRSSAPFS 2009
Score = 73.6 bits (179), Expect = 7e-13
Identities = 126/548 (22%), Positives = 228/548 (41%), Gaps = 81/548 (14%)
Query: 145 PLPSPVDKVAANT--PSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDT 202
P P P A+ P L + Q L+ A L + + L R LA + D+
Sbjct: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548
Query: 203 SWQALIDEDRLLSRLEVMGNQLQA-CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRV 261
+ + ++ E + S Q E +ALQE ES+RR
Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAE-------LALQE----------ESVRRS 1591
Query: 262 LQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKL 321
+E+ + +++ +ERSL TE E +QE++ ++ + + L + L
Sbjct: 1592 ERERRATLDQVATLERSLQATESEL-------RASQEKISKMKANETKLEGDKRRLKEVL 1644
Query: 322 KVAEGKQEEIQQKGQAEKKELQHK---IDEMEEKEQELQAKIEALQ---ADNDFTNERLT 375
+E + +++ + ++ + ELQ + + E + Q LQ ++++LQ AD++ L
Sbjct: 1645 DASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQ 1704
Query: 376 ALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLS 435
E L G + + E + V G LT+A+ ++ S N TR K L+
Sbjct: 1705 LTVERL----NGALAKVEES-EGALRDKVRG-LTEALAQSSASL-NSTRDKNLHLQKALT 1757
Query: 436 PSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEI--------EAKQEIQHLRK 487
+ Q L+E + S L + +Q + E+ EA+ ++Q LR+
Sbjct: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817
Query: 488 ELIEAQE---LARTSKQKCFELQALLEE----------ERKAYRNQVEESTKQIQVLQAQ 534
L + QE A + QK + + LL+E + +A + +VE S +++ +
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877
Query: 535 LQRL-----------HIDTENLREEK---DSEITSTRDELLSARDEILLLHQAAAKVASE 580
L+R H DT L EK D +T EL A+ +I L A V E
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE--AQVVVLE 1935
Query: 581 RDTDIASL----QEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEAT 636
+ A L Q++ +++ E+ER R A ++ E+ + + + + + R + E+Q
Sbjct: 1936 QSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
Query: 637 RLQGELEK 644
+LQ EL +
Sbjct: 1996 QLQQELRR 2003
Score = 69.7 bits (169), Expect = 1e-11
Identities = 96/460 (20%), Positives = 187/460 (40%), Gaps = 90/460 (19%)
Query: 338 EKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIE 397
E + Q + DE+ + L ++ ++A+ D R LQ+ +
Sbjct: 1517 ELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE------------ 1564
Query: 398 CQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNE 457
+ + V+G L+ E L +E+ R+ E++
Sbjct: 1565 -EARRSVDGRLSGVQAELALQEESVRRS--------------------------ERERRA 1597
Query: 458 PLAKVSLLKDDLQGAQSEIEAKQE-IQHLR-------------KELIEAQELARTSKQKC 503
L +V+ L+ LQ +SE+ A QE I ++ KE+++A E +RT K
Sbjct: 1598 TLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASE-SRTVK--- 1653
Query: 504 FELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENL-REEKDSEITSTRDELLS 562
LE +R++ +++ S + +AQ Q L ++L R+ DSE+ + +L
Sbjct: 1654 ------LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTV 1707
Query: 563 ARDEILLLHQAAAKVASERDT---DIASLQEELKKVRAELERWRKAASEYEKEITSLQNS 619
R L+ A AKV + L E L + A L R +K +T+ ++
Sbjct: 1708 ER-----LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
Query: 620 FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHN 679
Q+ Q+ D R+ + + + L ++ L E L+ + V +LQ+ + L
Sbjct: 1763 RQV-LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
Query: 680 SQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEK 739
Q+ + + LQ R+ L+ ++GSL+ L++ E + ++V++ +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQR-----------ALAQLEAEKREVERSALR 1870
Query: 740 TQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKG 779
+ L+ + E+EK L+ ++ ++L EKG
Sbjct: 1871 LEKDRVALRRTLDKVEREK------LRSHEDTVRLSAEKG 1904
Score = 67.8 bits (164), Expect = 4e-11
Identities = 135/637 (21%), Positives = 255/637 (40%), Gaps = 95/637 (14%)
Query: 169 SQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACS 228
SQ L+ AL R + +Q+ A+L ++ A+ +E D + A L + + N C
Sbjct: 212 SQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSA---NQALSEDIRKVTNDWTRCR 268
Query: 229 KN--QTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDEC 286
K E + R+E +E + Y + L + ++ + R +SEV+ TE +
Sbjct: 269 KELEHREAAWRRE----EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF---TERDL 321
Query: 287 THLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKI 346
L RT ++E LS L++AE + E +K + +L+ ++
Sbjct: 322 LQLGGELARTSRAVQEAG----------LGLSTGLRLAESRAEAALEKQALLQAQLEEQL 371
Query: 347 DEMEEKEQELQAKIEALQADNDFTNERLTAL-------QEHLLSKSGGDCTFIHQFIECQ 399
+ +E++L + D + R+T L ++ L K + + +E
Sbjct: 372 RDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK-LEAL 430
Query: 400 KKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQ------MDEQ 453
+ L ++ E+ + ++ ++ SD+ S + S+ T DA + Q
Sbjct: 431 ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490
Query: 454 DLNEPLAKVS--LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLE 511
P + S + +G + + L + Q + + + Q LL
Sbjct: 491 RTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLG 550
Query: 512 EERKAYRNQVEESTKQIQVLQAQLQRLHIDTENL---REEKDSEITSTR--DELLSARDE 566
RK Q+ +S + + L+ QLQRL T+ E+ E+ R +ELLS R++
Sbjct: 551 TLRK----QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-REK 605
Query: 567 ILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQ 626
L H + +VA ++ ++ +E+L+ + EL R R E +++
Sbjct: 606 SNLAH--SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAV------------ 651
Query: 627 CEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
++ R++ ELE+ ++ LE + L +E V + L R + Q + E
Sbjct: 652 ------QDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 687 LTSDLSILQMSRKELE-----------------NQVGSLKEQHLRDSADLKTLLSKAEN- 728
+ L+ + R ELE +++ +L E +D DL L+++ E
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 729 ----QAKDVQKEYEKT-----QTVLSELKLKFEMTEQ 756
Q + Q E E T Q L EL+L+ E+ Q
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
Score = 65.1 bits (157), Expect = 3e-10
Identities = 141/680 (20%), Positives = 260/680 (38%), Gaps = 110/680 (16%)
Query: 178 REQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLR 237
R Q E A Q + + ++A D Q D L E + QL+ D LR
Sbjct: 1121 RAQREEAAAAHAQEVRRLQEQARDLGKQ----RDSCLREAEELRTQLRLLE--DARDGLR 1174
Query: 238 KELIA----LQEDKHNYETTAKES--LRRVLQE---KIEVVRKLSEVERS-LSNTEDECT 287
+EL+ L+E + E +E+ LRR L E + E +R+ +E RS + E E
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
LK NE +++L L E +L L+ E + E ++ E +EL+ ++
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR----ELQELRRQMK 1290
Query: 348 EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQ-FIECQKKLIVEG 406
++ + L ++ LQ RL AL E +S + + Q ++ + L V
Sbjct: 1291 MLDSENTRLGRELAELQG-------RL-ALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342
Query: 407 HLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLA------ 460
+ + +E + R +E +L ++ A+ E L A
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402
Query: 461 -KVSLLKDDLQGAQSEIEAKQEIQH---------LRKELIEAQELART------------ 498
++S + QG ++E+ A+ E+Q LR L L R
Sbjct: 1403 LRLSAAEGRAQGLEAEL-ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Query: 499 ----------------SKQKCFE-----------LQALLEEERKAYRNQVEESTKQIQVL 531
S +C A + + +A R + E ++++
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
Query: 532 QAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEE 591
Q + L T L + +E+ + RD S ++ K +E + S+
Sbjct: 1522 QRERDELRTQTSALNRQL-AEMEAERDSATSRARQL-------QKAVAESEEARRSVDGR 1573
Query: 592 LKKVRAELERWRKAASEYEKE-------ITSLQNSFQ-----LRCQQCE-DQQREEATRL 638
L V+AEL ++ E+E + +L+ S Q LR Q + + + T+L
Sbjct: 1574 LSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKL 1633
Query: 639 QGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSR 698
+G+ +L++ +A E+ L+ + L ELQR L + + Q+ L + LQ
Sbjct: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
Query: 699 KELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEK 758
+ E + G+L+ R L L+K E ++ + L++ T +
Sbjct: 1694 ADSEVKAGTLQLTVER----LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKN 1749
Query: 759 QSITDELKQCKNNLKLLREK 778
+ L C+++ ++L+E+
Sbjct: 1750 LHLQKALTACEHDRQVLQER 1769
Score = 45.4 bits (106), Expect = 2e-04
Identities = 100/424 (23%), Positives = 176/424 (41%), Gaps = 62/424 (14%)
Query: 398 CQKKLIVEGHLTKAVEETKLS---KENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQD 454
CQ+K + L + + T L +E TR S L P+ E +S Q + Q
Sbjct: 28 CQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMAS--LLSLQEENQL 85
Query: 455 LNEPLAKVSLLKDDLQGAQSEIEAKQEI------QHLRKEL--IEAQELARTSKQKCFEL 506
L + L++V L + + E+ K Q LR E +E QE R ++ EL
Sbjct: 86 LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQE-PRGLVRQSVEL 144
Query: 507 QALLEEERKAYRNQV----EESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLS 562
+ L+EE+ +YR ++ E +Q Q++Q +LQ + + E + ++ EL
Sbjct: 145 RRQLQEEQASYRRKLQAYQEGQQRQAQLVQ-RLQGKILQYKKRCSELEQQLLERSGELEQ 203
Query: 563 AR----DEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQN 618
R + L A ++ E+ ASL + +R +L++ A ++I + N
Sbjct: 204 QRLRDTEHSQDLESALIRLEEEQQRS-ASLAQVNAMLREQLDQAGSANQALSEDIRKVTN 262
Query: 619 SFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHS-------------------- 658
+ RC++ E + RE A R + E +NA + HS
Sbjct: 263 DW-TRCRK-ELEHREAAWRREEE------SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVK 314
Query: 659 --LKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKE--LENQ--VGSLKEQH 712
+R+ + L EL R + + Q+ L L++ L + + SR E LE Q + + E+
Sbjct: 315 MFTERDLLQLGGELARTSRAV---QEAGLGLSTGLRLAE-SRAEAALEKQALLQAQLEEQ 370
Query: 713 LRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNL 772
LRD + L++ + Q+ + + T L + E EK + +L + L
Sbjct: 371 LRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL 430
Query: 773 KLLR 776
+ LR
Sbjct: 431 ESLR 434
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 104 bits (260), Expect = 3e-22
Identities = 157/658 (23%), Positives = 276/658 (41%), Gaps = 98/658 (14%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D +++L LQ + QT D L+ E
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE-THQQTLDDLQAE-- 1016
Query: 242 ALQEDKHNYETTAKESLRRV---LQEKIEVVRKLS-EVERSLSNTEDECTHLKEMNERTQ 297
EDK N T AK L + L+ +E +KL ++ER+ E + +E +
Sbjct: 1017 ---EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073
Query: 298 EELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEM-EEKEQEL 356
+ ++L K EI +L K++ + + ++Q+K KELQ +I+E+ EE E E
Sbjct: 1074 NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKK----IKELQARIEELGEEIEAER 1129
Query: 357 QAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGH-LTKAVEET 415
++ +A + +D + E L + E L G + E KK E L + +EE
Sbjct: 1130 ASRAKAEKQRSDLSRE-LEEISERLEEAGGATSAQV----ELNKKREAEFQKLRRDLEEA 1184
Query: 416 KLSKENQT---RAKESDFS-------DTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLL 465
L E R K +D D L K+K + ++ +M+ DL+ +S
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKA 1244
Query: 466 KDDLQ-------GAQSEIEAKQE-----IQHLRKELIEAQELARTSKQKCFELQALLEEE 513
K +L+ SE++ K+E I L + Q A ++ E AL+ +
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQL 1304
Query: 514 RKA----------YRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSA 563
++ ++Q+EE TK L LQ D + LRE+ + E + EL A
Sbjct: 1305 SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEE-QEGKAELQRA 1363
Query: 564 RDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAASEY----------- 609
L +A ++VA R +TD EEL++ + +L + + A E+
Sbjct: 1364 ------LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 610 EKEITSLQNSFQ----------LRCQQCEDQQR----------EEATRLQGELEKLRKEW 649
EK LQN + C + +QR ++ Q ELE +KE
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKES 1477
Query: 650 NALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLK 709
+L TE +K +L+ +E N Q++ +LT ++ ELE +K
Sbjct: 1478 RSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELE----KIK 1533
Query: 710 EQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQ 767
+Q ++ +++ L +AE + + + + Q L+++K + + EK D+LK+
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1591
Score = 100 bits (248), Expect = 7e-21
Identities = 143/657 (21%), Positives = 291/657 (44%), Gaps = 64/657 (9%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
YS++L + + + +Q Q++ L+ L +A + AL L
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
+ Q K + + +L K + + + YET A + + + K ++ ++L E E +
Sbjct: 1350 YEEEQE-GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE 1408
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C L++ +R Q E+ +L +N A+++ + DK+ ++E KQ EE Q
Sbjct: 1409 AVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKV-LSEWKQKYEETQ 1467
Query: 333 QKGQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ +A +KE L ++ +++ +E ++E L+ +N + ++ L E + GG
Sbjct: 1468 AELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE--GGKQ 1525
Query: 390 TFIHQFIECQKKLIVEG-HLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDA 448
IH+ + +K++ E + A+EE + S E++ + L ++ KS D A
Sbjct: 1526 --IHELEKIKKQVEQEKCEIQAALEEAEASLEHE---EGKILRIQLELNQVKSEVDRKIA 1580
Query: 449 QMDEQ--DLNEPLAKV-----SLLKDDLQGAQSEIEAKQEIQ----HLRKELIEAQELAR 497
+ DE+ L +V S L +++ + K++++ + +L A LA
Sbjct: 1581 EKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAA 1640
Query: 498 TSKQKCFELQALLEEER----KAYRNQVEESTKQIQVLQAQLQRLHIDTENL---REEKD 550
S + Q +L+E + A R Q E+ +Q+ +++ + L + E L E+ +
Sbjct: 1641 ESLRNYRNTQGILKETQLHLDDALRGQ-EDLKEQLAIVERRANLLQAEIEELWATLEQTE 1699
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAAS 607
ELL A + + LLH + + + + D++ LQ E+++V ++ R A
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV---IQESRNAEE 1756
Query: 608 EYEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL--- 659
+ +K IT E+ ++E+ T R++ LE+ K+ E L
Sbjct: 1757 KAKKAITDA-------AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1809
Query: 660 --KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSA 717
K++ L + ++ E E+ N QK++ E L + KEL Q ++ LR
Sbjct: 1810 GGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQD 1869
Query: 718 DLKTLLSKAENQAKDVQKEYEKTQTVLSEL-KLKFEMTEQEKQSITDELKQCKNNLK 773
+ L +K ++ + ++ E++ LS+ KL+ E+ E E+++ E + K +K
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVK 1926
Score = 95.9 bits (237), Expect = 1e-19
Identities = 149/677 (22%), Positives = 270/677 (39%), Gaps = 89/677 (13%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
QL ++E R + E+ A L ++ + + D + L+++E + +
Sbjct: 917 QLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 976
Query: 227 CSKNQTED--SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
KN TE+ L + + L ++K + T +++L LQ + + V L++ + L D
Sbjct: 977 KVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD-LQAEEDKVNILTKAKTKLEQQVD 1035
Query: 285 ECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQH 344
+ E ++ + +L K G + ++ + ++ + + +E +K + E L
Sbjct: 1036 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLIS 1095
Query: 345 KIDEMEEKEQELQAKIEALQADNDFTNERLTA------------------LQE--HLLSK 384
KI++ + E +LQ KI+ LQA + E + A L+E L +
Sbjct: 1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 385 SGGDCTFIHQFIECQKKLIVE-GHLTKAVEETKLSKENQT---RAKESDFS-------DT 433
+GG + +E KK E L + +EE L E R K +D D
Sbjct: 1156 AGGATS---AQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDN 1212
Query: 434 LSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQ 493
L K+K + ++ +M+ DL+ +S K +L+ +E ++ L+ + E Q
Sbjct: 1213 LQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE--DQVSELKTKEEEQQ 1270
Query: 494 ELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---EEKD 550
L + +A L+ E Y Q++E + L Q E L+ EE+
Sbjct: 1271 RLINDLTAQ----RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 1326
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKA----A 606
+ L S+R + LL + E A LQ L K +E+ +WR A
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQ----YEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 607 SEYEKEITSLQNSFQLRCQQCED----------QQREEATRLQGELEKLRKEWNALETEC 656
+ +E+ + R Q+ E+ + RLQ E+E L + C
Sbjct: 1383 IQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAAC 1442
Query: 657 HSLKRE----NVLLSSELQRQEK---ELHNSQKQSLELTSD--------------LSILQ 695
+L ++ + +LS Q+ E+ EL SQK+S L+++ L L+
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR 1502
Query: 696 MSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTE 755
K L+ ++ L EQ + L E K V++E + Q L E + E E
Sbjct: 1503 RENKNLQQEISDLTEQIAEGGKQIHEL----EKIKKQVEQEKCEIQAALEEAEASLEHEE 1558
Query: 756 QEKQSITDELKQCKNNL 772
+ I EL Q K+ +
Sbjct: 1559 GKILRIQLELNQVKSEV 1575
Score = 91.7 bits (226), Expect = 3e-18
Identities = 122/550 (22%), Positives = 248/550 (45%), Gaps = 59/550 (10%)
Query: 238 KELIALQED--KHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNER 295
KE+ ++E+ K E E+ R+ L+EK+ V L E + E L + ER
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKM--VTLLKEKNDLQLQVQSEADSLADAEER 907
Query: 296 TQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQE 355
++ ++ NK +IK+++++ + ++EEI + A+K++L+ + E+++ +
Sbjct: 908 CEQLIK---NKIQLEA-KIKEVTERAE----EEEEINAELTAKKRKLEDECSELKKDIDD 959
Query: 356 LQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEET 415
L+ + ++ + T ++ L E + +G D T KL E KA++ET
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEM---AGLDETIA--------KLSKE---KKALQET 1005
Query: 416 KLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSE 475
+ +A+E D + L+ +K K + Q+D DL L + L+ DL+ A+ +
Sbjct: 1006 HQQTLDDLQAEE-DKVNILTKAKTK-----LEQQVD--DLEGSLEQEKKLRMDLERAKRK 1057
Query: 476 IEAKQEIQHLRKELIE--AQELARTSKQKCFELQALLE--EERKAYRNQVEESTKQIQVL 531
+E ++ +E Q+L ++K FE+ L+ E+ +A Q++ K+I+ L
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ---KKIKEL 1114
Query: 532 QAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEE 591
QA+++ L + E R + ++ R +L +EI + A S + + E
Sbjct: 1115 QARIEELGEEIEAERASR-AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE 1173
Query: 592 LKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNA 651
+K+R +LE +A ++E + +L+ + + L +++ L++
Sbjct: 1174 FQKLRRDLE---EATLQHEAMVAALRK-----------KHADSMAELGEQIDNLQRVKQK 1219
Query: 652 LETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQ 711
LE E LK E LSS + K N +K L +S L+ +E + + L Q
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279
Query: 712 HLR---DSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQC 768
R ++ + L + + + + + + + ELK + E + K ++ L+
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS 1339
Query: 769 KNNLKLLREK 778
+++ LLRE+
Sbjct: 1340 RHDCDLLREQ 1349
Score = 83.2 bits (204), Expect = 9e-16
Identities = 111/564 (19%), Positives = 242/564 (42%), Gaps = 45/564 (7%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
+L+Q LQEA + + K A+L++ Q + ++D +R + + + +
Sbjct: 1395 KLAQRLQEAEEHVEAVNAKCASLEKT---KQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDEC 286
K L E K YE T E L +E + +L +V+ + D+
Sbjct: 1452 FDK------------VLSEWKQKYEETQAE-LEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 287 THLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKI 346
L+ N+ Q+E+ +L + +I +L K E ++ EIQ + + L+H+
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEE 1558
Query: 347 D-------EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQ 399
E+ + + E+ KI + D T + E + S + + + +
Sbjct: 1559 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVK 1618
Query: 400 KKLIVEGHLTKAVEETKLSKENQTRAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQDLNEP 458
KK+ EG L + E +L+ N+ A+ ++ +T KE DA ++DL E
Sbjct: 1619 KKM--EGDLNEM--EIQLNHANRLAAESLRNYRNTQGILKETQLH-LDDALRGQEDLKEQ 1673
Query: 459 LA----KVSLLKDDLQGAQSEIEAKQEIQHL-RKELIEAQE---LARTSKQKCFELQALL 510
LA + +LL+ +++ + +E + + + +EL++A E L T + L
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1733
Query: 511 EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELL------SA 563
E + +++VEE ++ + + + ++ D + EE K + TS E + +
Sbjct: 1734 ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1793
Query: 564 RDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLR 623
+D L +A I L+ ++++ E+E +K +E K + + +
Sbjct: 1794 KDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKEL 1853
Query: 624 CQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQ 683
Q E+ R+ RLQ ++KL+ + + + + + ++ S+ ++ + EL ++++
Sbjct: 1854 TYQTEED-RKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEER 1912
Query: 684 SLELTSDLSILQMSRKELENQVGS 707
+ S ++ L++ +E+ ++ +
Sbjct: 1913 ADIAESQVNKLRVKSREVHTKISA 1936
Score = 61.2 bits (147), Expect = 4e-09
Identities = 67/325 (20%), Positives = 140/325 (43%), Gaps = 25/325 (7%)
Query: 465 LKDDLQGAQSEIEA---KQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQV 521
+K L+ A++E E K+E Q + EL +++ + ++K L +E+ + QV
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEK----MVTLLKEKNDLQLQV 894
Query: 522 EESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASER 581
+ + + + ++L I + E K E+T +E E+ + SE
Sbjct: 895 QSEADSLADAEERCEQL-IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 582 DTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQ---CEDQQREEATRL 638
DI L+ L KV E +E+ L + ++ ++ ++ L
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 639 QGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSR 698
Q E +K+ N L L+++ L L++++K + ++ +L DL + Q S
Sbjct: 1014 QAEEDKV----NILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069
Query: 699 KELENQVGSLKEQHLRDSADLKTLLSKAENQAK---DVQKEYEKTQTVLSELKLKFE--- 752
++EN L E+ + ++ L+SK E++ +QK+ ++ Q + EL + E
Sbjct: 1070 MDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 1129
Query: 753 ----MTEQEKQSITDELKQCKNNLK 773
E+++ ++ EL++ L+
Sbjct: 1130 ASRAKAEKQRSDLSRELEEISERLE 1154
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/227 (22%), Positives = 107/227 (47%), Gaps = 31/227 (13%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++E + ++A+++EE +K + EL + E E+++ +L +N QL+ Q
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 626 --QCE---------DQQREEATRLQGELEKLRKEWNA----LETECHSLKRENVLLSSEL 670
+CE + + +E T E E++ E A LE EC LK++ L L
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQA 730
+ EKE H ++ + LT +++ L + +L + +L+E H + DL+ E++
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA----EEDKV 1020
Query: 731 KDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+ K K + + +L+ E ++ + + ++ + +LKL +E
Sbjct: 1021 NILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 103 bits (256), Expect = 8e-22
Identities = 153/668 (22%), Positives = 283/668 (42%), Gaps = 104/668 (15%)
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
LE LA +++ T+ + + D +++L LQ + QT D L+ E
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ-QTLDDLQAE-- 1017
Query: 242 ALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELR 301
EDK N T AK I++ +++ ++E SL + L+ + + +L+
Sbjct: 1018 ---EDKVNTLTKAK----------IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064
Query: 302 ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK---ELQHKIDEMEEKEQELQA 358
N+ + L +KLK E + +Q K + E+ +LQ KI E++ + +EL+
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 359 KIEALQADNDFTNERLTALQEHL------LSKSGGDCTFIHQFIECQKKLIVEGH-LTKA 411
+IEA +A ++ + L L L ++GG + IE KK E + +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS---AQIEMNKKREAEFQKMRRD 1181
Query: 412 VEETKLSKENQT---RAKESDFS-------DTLSPSKEKSSDDTTDAQMDEQDLNEPLAK 461
+EE L E R K +D D L K+K + ++ +M+ DL +
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 462 VSLLKDDLQ-------GAQSEIEAKQEIQHLRKELIEAQ---------ELARTSKQKCFE 505
VS K +L+ SEI+ K+E Q + AQ E +R +K
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD-T 1300
Query: 506 LQALLEEERKAYRNQVEESTKQIQ-------VLQAQLQRLHIDTENLREEKDSEITSTRD 558
L + L ++A+ Q+EE +Q++ L LQ D + LRE+ + E +
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE-QEAKA 1359
Query: 559 ELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEY--------- 609
EL A + + A+ ++ +TD EEL++ + +L + + A E+
Sbjct: 1360 ELQRAMSKA---NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 1416
Query: 610 --EKEITSLQNSFQ----------LRCQQCEDQQR----------EEATRLQGELEKLRK 647
EK LQN + C + +QR ++ ELE +K
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1476
Query: 648 EWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGS 707
E +L TE +K +L+ ++E N Q++ +LT ++ ELE
Sbjct: 1477 ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE----K 1532
Query: 708 LKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQ 767
+K+Q ++ ++L+ L +AE + + + + Q L+++K + + EK D++K
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK- 1591
Query: 768 CKNNLKLL 775
+N+++++
Sbjct: 1592 -RNHIRIV 1598
Score = 101 bits (251), Expect = 3e-21
Identities = 138/661 (20%), Positives = 289/661 (43%), Gaps = 67/661 (10%)
Query: 161 YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVM 220
YS++L + + + +Q Q++ L+R L +A AL L
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ 1350
Query: 221 GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS 280
+ Q +K + + ++ K + + + YET A + + + K ++ ++L + E +
Sbjct: 1351 YEEEQE-AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 281 NTEDECTHLKEMNERTQEELREL------ANKYNGAVNEIKDLSDKLKVAEGKQ--EEIQ 332
+C L++ +R Q E+ +L N A+++ + DK+ +AE KQ EE
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI-LAEWKQKCEETH 1468
Query: 333 QKGQAEKKE---LQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDC 389
+ +A +KE L ++ +++ +E ++E L+ +N + ++ L E + GG
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE--GGKR 1526
Query: 390 TFIHQFIECQKKLIVE-GHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDA 448
IH+ + +K++ E L A+EE + S E++ + L ++ KS D A
Sbjct: 1527 --IHELEKIKKQVEQEKSELQAALEEAEASLEHE---EGKILRIQLELNQVKSEVDRKIA 1581
Query: 449 QMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRK-----------ELIEAQELAR 497
+ DE+ + +++ +EI ++ + L+K +L A +A
Sbjct: 1582 EKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641
Query: 498 TSKQKCFELQALLEEER----KAYRNQVEESTKQIQVLQAQLQRLHIDTENLR---EEKD 550
+ + QA+L++ + A R+Q E+ +Q+ +++ + L + E LR E+ +
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTE 1700
Query: 551 SEITSTRDELLSARDEILLLHQAAAKVASER---DTDIASLQEELKKVRAELERWRKAAS 607
ELL A + + LLH + + + +TDI+ +Q E++ + ++ R A
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI---IQEARNAEE 1757
Query: 608 EYEKEITSLQNSFQLRCQQCEDQQREEAT-----RLQGELEKLRKEWNALETECHSL--- 659
+ +K IT E+ ++E+ T R++ LE+ K+ E L
Sbjct: 1758 KAKKAITDA-------AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 660 --KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSA 717
K++ L + ++ E E+ + QK+++E L + KEL Q ++ LR
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR--- 1867
Query: 718 DLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
L+ L+ K + + K +++ E+ + + KF + E + + ++ + LR
Sbjct: 1868 -LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRV 1926
Query: 778 K 778
K
Sbjct: 1927 K 1927
Score = 97.1 bits (240), Expect = 6e-20
Identities = 112/529 (21%), Positives = 227/529 (42%), Gaps = 55/529 (10%)
Query: 280 SNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEK 339
+ TE E ++KE E+T+EEL + K K+L +K+ ++ ++Q + QAE
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKR-------KELEEKMVTLMQEKNDLQLQVQAEA 899
Query: 340 KEL---QHKIDEMEEKEQELQAKIEAL---QADNDFTNERLTALQEHL------LSKSGG 387
L + + D++ + + +L+AKI+ + D + N LTA + L L K
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 388 DCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTD 447
D +E ++K E + EE ++ ++T AK + L + +++ DD
Sbjct: 960 DLELTLAKVE-KEKHATENKVKNLTEE--MAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 448 AQMDEQDLNEPLAKVSLLKDDLQGA-QSEIEAKQEIQHLRKELIEAQELARTS------- 499
+ L + K+ DDL+G+ + E + + +++ +++L +LA+ S
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076
Query: 500 KQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDE 559
KQ+ E E E ++++E+ LQ +++ L E L EE ++E S
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERAS---- 1132
Query: 560 LLSARDEILLLHQAAAKVASERDTDIASLQEELKK----VRAELERWRKAASEYEKEITS 615
A K S+ ++ + E L++ A++E +K +E++K
Sbjct: 1133 -----------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 616 LQNS---FQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQR 672
L+ + + + + L +++ L++ LE E +K E L+S ++
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 673 QEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLR---DSADLKTLLSKAENQ 729
K N +K L LS ++ +E + + L Q R +S + L + +
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 730 AKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
+ + + + ELK + E + K ++ L+ +++ LLRE+
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ 1350
Score = 95.1 bits (235), Expect = 2e-19
Identities = 134/664 (20%), Positives = 272/664 (40%), Gaps = 63/664 (9%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
QL ++E R + E+ A L ++ + + D + L+++E + +
Sbjct: 918 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977
Query: 227 CSKNQTED--SLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
KN TE+ L + + L ++K + +++L LQ + + V L++ + L D
Sbjct: 978 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD-LQAEEDKVNTLTKAKIKLEQQVD 1036
Query: 285 ECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQH 344
+ E ++ + +L K G + ++ + ++ + + +E +K + E LQ
Sbjct: 1037 DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS 1096
Query: 345 KIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIV 404
KI++ + +LQ KI+ LQA + E + A + + E ++L
Sbjct: 1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 405 EGHLTKAVEETKLSKENQTRAKESDFSD-------TLSPSKEKSSDDTTD-------AQM 450
G T A E +E + + D + T + ++K +D + Q
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 451 DEQDLNEPLAKVSLLKDDLQGAQSEI-EAKQEIQHLRKELIEAQELARTSKQKCFEL--- 506
+Q L + +++ + DDL + +AK ++ + + L + +T +++ L
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 507 ----QALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEI---TSTRDE 559
+A L+ E Y Q++E + L Q E L+ + + EI ++
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 560 LLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKA----ASEYEKEITS 615
L S+R + LL + E A LQ + K +E+ +WR A + +E+
Sbjct: 1337 LQSSRHDCDLLREQ----YEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 616 LQNSFQLRCQQCED----------QQREEATRLQGELEKLRKEWNALETECHSLKRE--- 662
+ R Q E+ + RLQ E+E L + C +L ++
Sbjct: 1393 AKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN 1452
Query: 663 -NVLLSSELQRQEK---ELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSAD 718
+ +L+ Q+ E+ EL SQK+S L+++L ++ + +E +Q+ +LK ++ +
Sbjct: 1453 FDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQE 1512
Query: 719 LKTL----------LSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQC 768
+ L + + E K V++E + Q L E + E E + I EL Q
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 769 KNNL 772
K+ +
Sbjct: 1573 KSEV 1576
Score = 93.6 bits (231), Expect = 7e-19
Identities = 139/600 (23%), Positives = 259/600 (43%), Gaps = 108/600 (18%)
Query: 238 KELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL-------- 289
KE +A E K +E + ++QEK ++ ++ SL++ E+ C L
Sbjct: 864 KEELAKTEAKRK---ELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLE 920
Query: 290 ---KEMNERTQE------ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKK 340
KE+ ER ++ EL K +E+K D L++ K E+ + + + K
Sbjct: 921 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 341 ELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQK 400
L ++ ++E +L + +ALQ + T + L A ++ + + + Q +
Sbjct: 981 NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD--- 1037
Query: 401 KLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLA 460
+EG L E+ K + + RAK L + + + T D + D+Q L+E L
Sbjct: 1038 ---LEGSL----EQEKKIRMDLERAKRK-----LEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 461 KVSLLKDDLQGAQSEIEAKQEI-QHLRKELIEAQELARTSKQKCFELQALLEEERKAYRN 519
K ++ G QS+IE +Q + L+K++ E Q AR + LEEE +A R
Sbjct: 1086 KKEF---EMSGLQSKIEDEQALGMQLQKKIKELQ--ARIEE---------LEEEIEAERA 1131
Query: 520 QVEESTKQIQVLQAQLQRLHIDTE----------NLREEKDSEITSTRDELLSARDEILL 569
++ KQ L +L+ + E + +++++E R +L +E L
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL----EEATL 1187
Query: 570 LHQAAAKVASERDTD-IASLQEELKKVRAELERWRKAASEYEKEITSL----------QN 618
H+A A ++ D +A L E++ ++ ++ K SE + EI L +
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247
Query: 619 SFQLRCQQCEDQ------QREEATRLQGELEKLRKEWNALETECHSLKR---ENVLLSSE 669
+ + C+ EDQ + EE RL +L R L+TE R E L S+
Sbjct: 1248 NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRAR---LQTESGEYSRQLDEKDTLVSQ 1304
Query: 670 LQR-------QEKELHNSQKQSLELTSDLS-ILQMSRKELENQVGSLKEQHLRD---SAD 718
L R Q +EL ++ ++ S L+ LQ SR + + L+EQ+ + A+
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD----LLREQYEEEQEAKAE 1360
Query: 719 LKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREK 778
L+ +SKA ++ + +YE ++ + E E+ K+ + L+ + +++ + K
Sbjct: 1361 LQRAMSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Score = 90.5 bits (223), Expect = 6e-18
Identities = 134/659 (20%), Positives = 269/659 (40%), Gaps = 83/659 (12%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQ-EASDTSWQALIDEDRLLSRLEVMGNQLQ 225
QL + ++E R + LE+++ + A + + SD S + +RL Q++
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1166
Query: 226 ACSKNQTE-DSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTED 284
K + E +R++L +E +E TA ++ E+ ++ ++R E
Sbjct: 1167 MNKKREAEFQKMRRDL---EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1223
Query: 285 ECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQ----------K 334
E + +K + + ++ + L D+L + K+EE Q+ +
Sbjct: 1224 EKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRAR 1283
Query: 335 GQAEKKELQHKIDE-------MEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGG 387
Q E E ++DE + +Q +IE L+ + + +AL H L S
Sbjct: 1284 LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA-HALQSSRH 1342
Query: 388 DCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAK-ESDF---SDTLSPSKEKSSD 443
DC + + E +++ E L +A+ + S+ Q R K E+D ++ L +K+K +
Sbjct: 1343 DCDLLREQYEEEQEAKAE--LQRAMSKAN-SEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 444 DTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQH-----LRKELIEAQELART 498
DA+ + +N A + K LQ ++ E + L K+ ++
Sbjct: 1400 RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAE 1459
Query: 499 SKQKCFELQALLEEERKAYR----------NQVEESTKQIQVLQAQLQRLHIDTENLREE 548
KQKC E A LE +K R N EES Q++ L+ + + L + +L E+
Sbjct: 1460 WKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 1519
Query: 549 ------KDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERW 602
+ E+ + ++ + E+ + A + I +Q EL +V++E++R
Sbjct: 1520 IAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR- 1578
Query: 603 RKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRE 662
+E ++EI ++ + +R + + R + + +L+K+
Sbjct: 1579 --KIAEKDEEIDQMKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKK-------------- 1621
Query: 663 NVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTL 722
+ +L E +L+++ + + E + Q K+ + + + LR DLK
Sbjct: 1622 ---MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL----DDALRSQEDLKEQ 1674
Query: 723 LSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNN 781
L+ E +A +Q E E EL+ E TE+ ++ EL ++LL + +
Sbjct: 1675 LAMVERRANLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Score = 77.4 bits (189), Expect = 5e-14
Identities = 111/562 (19%), Positives = 236/562 (41%), Gaps = 45/562 (8%)
Query: 167 QLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQA 226
+L+Q LQ+A + + K A+L++ Q + +ID +R + + + +
Sbjct: 1396 KLAQRLQDAEEHVEAVNAKCASLEKT---KQRLQNEVEDLMIDVERTNAACAALDKKQRN 1452
Query: 227 CSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDEC 286
K L E K E T E L +E + +L +++ + + D+
Sbjct: 1453 FDK------------ILAEWKQKCEETHAE-LEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 287 THLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKI 346
LK N+ Q+E+ +L + I +L K E ++ E+Q + + L+H+
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEE 1559
Query: 347 D-------EMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQ 399
E+ + + E+ KI + D + E + S + + I +
Sbjct: 1560 GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619
Query: 400 KKLIVEGHLTKAVEETKLSKENQTRAKE-SDFSDTLSPSKEKSSDDTTDAQMDEQDLNEP 458
KK+ EG L + E +L+ N+ A+ ++ +T + K+ DA ++DL E
Sbjct: 1620 KKM--EGDLNEM--EIQLNHANRMAAEALRNYRNTQAILKDTQLH-LDDALRSQEDLKEQ 1674
Query: 459 LAKVSLLKDDLQGAQSEIEAK-QEIQHLRK----ELIEAQE---LARTSKQKCFELQALL 510
LA V + LQ E+ A ++ + RK EL++A E L T + L
Sbjct: 1675 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1734
Query: 511 EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREE-KDSEITSTRDELL------SA 563
E + + ++E+ ++ + + + ++ D + EE K + TS E + +
Sbjct: 1735 ETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1794
Query: 564 RDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLR 623
+D L +A I L+ ++++ E+E +K E K + + +
Sbjct: 1795 KDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKEL 1854
Query: 624 CQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQ 683
Q E+ R+ RLQ ++KL+ + + + + + ++ + S+ +R + EL ++++
Sbjct: 1855 TYQTEED-RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEER 1913
Query: 684 SLELTSDLSILQMSRKELENQV 705
+ S ++ L++ +E+ ++
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKI 1935
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/252 (24%), Positives = 115/252 (45%), Gaps = 51/252 (20%)
Query: 578 ASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSL---QNSFQLRCQ--------- 625
++E + ++A+++EE +K + EL + E E+++ +L +N QL+ Q
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 626 ------------QCEDQQREEATRLQGELE---KLRKEWNALETECHSLKRENVLLSSEL 670
Q E + +E R + E E +L + LE EC LK++ L L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 671 QRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLK------TLLS 724
+ EKE H ++ + LT +++ L + +L + +L+E H + DL+ L+
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 725 KAE--------------NQAKDVQKEYEKTQTVL-SELKLKFEMT---EQEKQSITDELK 766
KA+ Q K ++ + E+ + L +LKL E T E +KQ + ++LK
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 767 QCKNNLKLLREK 778
+ + + L+ K
Sbjct: 1086 KKEFEMSGLQSK 1097
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 103 bits (256), Expect = 8e-22
Identities = 125/611 (20%), Positives = 267/611 (43%), Gaps = 84/611 (13%)
Query: 168 LSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQAC 227
+++ L+E L+ K+ L+R L +++E + ++D + + +E + Q++
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQEL---VILDAENSKAEVETLKTQIEEM 2194
Query: 228 SKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECT 287
+++ L +L+ L+ +K N L + +QEK +LSE+++ LS+ +
Sbjct: 2195 ARSLKVFEL--DLVTLRSEKEN--------LTKQIQEK---QGQLSELDKLLSSFKSLLE 2241
Query: 288 HLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKID 347
++ + +EE + N++K+L++ + G QE + K + +D
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQ---NQLKELNEAVAALCGDQEIM--------KATEQSLD 2290
Query: 348 EMEEKEQELQAKIEALQADNDFTNER-LTALQEHLLSKSGGDCTFIHQFIECQKKLIVEG 406
E+E +L+ IE L+A + ++ L LQ+ S+ D +++G
Sbjct: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD--------------LLKG 2336
Query: 407 HLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLK 466
+ E ++++ NQ A +A+ + ++ AK+ +
Sbjct: 2337 RVENLERELEIARTNQEHA-------------------ALEAENSKGEVETLKAKIEGMT 2377
Query: 467 DDLQGAQSEIEA-KQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEEST 525
L+G + ++ + E ++L EL + QE + + +L+E+ + E+S+
Sbjct: 2378 QSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS 2437
Query: 526 KQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAA-KVASERDTD 584
+++LQ QL+ L+ L D E +++ LS++ E L L +A + E +
Sbjct: 2438 TAMEMLQTQLKELNERVAALHN--DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 585 IASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEK 644
LQ + + E+E ++ + ++EI+ L+N Q +DQ E+
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN-------QIQDQ------------EQ 2536
Query: 645 LRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQ 704
L + + +E E K +N+ L + E+++ Q ++ L L +LQ S K LEN+
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENE 2596
Query: 705 VGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE 764
+ K + + + +K +++ + +KT + EL + E Q + +E
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEE 2656
Query: 765 LKQCKNNLKLL 775
+K K+ LK L
Sbjct: 2657 IKSSKDQLKEL 2667
Score = 102 bits (253), Expect = 2e-21
Identities = 138/640 (21%), Positives = 280/640 (43%), Gaps = 79/640 (12%)
Query: 190 QRLLAITQEASDT-SWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKH 248
+R L + E S S +A I+ + L ++ Q + + ++ +K ++ L+E+
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL- 1953
Query: 249 NYETTAKESLRRVLQEKI-------EVVRKLSEVERSLSNTEDECTHLKEMNERTQEELR 301
+ T+ + LR L ++ K+ E + L + + EC H ++ E +E
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 302 ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQA---EKKELQHKIDEMEEKEQELQA 358
EL + V+E+ L DK + E K + +++ QA K EL+++I ++ ++++ L
Sbjct: 2014 ELLQTLSSDVSEL--LKDKTHLQE-KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
Query: 359 KIEALQA---DNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEET 415
+ E+LQA ++D+ ++ E L + G F + Q+++ L + +E+
Sbjct: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKG---EFALRLSSTQEEV---HQLRRGIEKL 2124
Query: 416 KLSKENQTRAKESDFSDTLSPSKEKSSDDTTD-AQMDEQDLNEPLAKVSLLKDDLQGAQS 474
++ E + K+ ++ L +E+ +D D + E++L L+ D + +++
Sbjct: 2125 RVRIEADEK-KQLHIAEKLK-ERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
Query: 475 EIEA-KQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQA 533
E+E K +I+ + + L K FEL + R++ E TKQIQ Q
Sbjct: 2183 EVETLKTQIEEMARSL------------KVFELDLV------TLRSEKENLTKQIQEKQG 2224
Query: 534 Q---LQRLHIDTENLREEKDSEITSTRDELLSA----RDEILLLHQAAAKVASERDTDIA 586
Q L +L ++L EEK+ ++E +A ++++ L++A A + +++ A
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 587 S-------------LQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQRE 633
+ L+ ++K+RA LE K +++ ++ L + E+ +RE
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERE 2344
Query: 634 -------------EATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNS 680
EA +GE+E L+ + + L+ + V + SE + EL
Sbjct: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
Query: 681 QKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKT 740
Q++ EL S + +E E + +KE+ L+T L + + + + E
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Query: 741 QTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGN 780
+ L + E E EK + L + KNN +L+ N
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Score = 93.6 bits (231), Expect = 7e-19
Identities = 139/685 (20%), Positives = 290/685 (42%), Gaps = 98/685 (14%)
Query: 133 MEARLRSDV-----IHAPLPSPVDKVAA------NTPSMYSQELFQLSQYLQEALHREQM 181
M+ARL ++ +H L + +DK+ + N + Q+L + Q Q + +E
Sbjct: 417 MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
Query: 182 LEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELI 241
L + + +++ + + S+ + + + L ++ NQ S+N E+ K
Sbjct: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ----SQNFAEEMKAKN-- 530
Query: 242 ALQEDKHNYETTAKESLRRVLQEKI---EVVRKLSEVERSLSNTEDECTHLKEMNERTQE 298
T++E++ R LQEKI E L +++ ++++ E + +++ ++ +
Sbjct: 531 -----------TSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH 579
Query: 299 ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKG-----------------QAEKKE 341
+ +L +K + E K L L++ + + EE++++ ++EK+
Sbjct: 580 HIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKEN 639
Query: 342 LQHKIDEMEE-------KEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQ 394
LQ KI+ +E K E ++ L+ D + + + L L SKS T
Sbjct: 640 LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLA 699
Query: 395 FIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQD 454
++E Q+K + E K +Q + D L + S++ D QD
Sbjct: 700 YMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL----QLLSNEIMDKDRCYQD 755
Query: 455 LNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKEL-IEAQELARTSKQKCFELQALLEEE 513
L+ A+ L+D L+ + + ++ H R L + Q S Q + E
Sbjct: 756 LH---AEYESLRDLLKSKDASLVTNED--HQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 514 RKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQA 573
R R + ++S K +LQ ++ L E+ +++ +S++ +EL+ + EI +
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLES-QKQMNSDLQKQCEELVQIKGEI---EEN 866
Query: 574 AAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQRE 633
K + +A + + K++ + + +E + + + QL + E +Q
Sbjct: 867 LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ-- 924
Query: 634 EATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSI 693
E+++L+K + LE L+ LLS L ++KE+ +S +S+
Sbjct: 925 ------AEIQELKKSNHLLEDSLKELQ----LLSETLSLEKKEM----------SSIISL 964
Query: 694 LQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEM 753
+ +EL + G+LKE + + + L+ K+E+ A + E EK+ + LS +
Sbjct: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID-EREKSISELS------DQ 1017
Query: 754 TEQEKQSITDELKQCKNNLKLLREK 778
+QEK + ++ N + L +K
Sbjct: 1018 YKQEKLILLQRCEETGNAYEDLSQK 1042
Score = 91.3 bits (225), Expect = 3e-18
Identities = 148/660 (22%), Positives = 285/660 (43%), Gaps = 69/660 (10%)
Query: 148 SPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAIT------QEASD 201
S +DK+ ++ S+ ++ Q +E+ +ML+ +L L +A +A++
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATE 2286
Query: 202 TSWQALIDED-RLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRR 260
S I+E+ +L + +E + +L+A K K+L LQ+ K + E A R
Sbjct: 2287 QSLDPPIEEEHQLRNSIEKLRARLEADEK--------KQLCVLQQLKES-EHHADLLKGR 2337
Query: 261 V--LQEKIEVVRKLSE-VERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDL 317
V L+ ++E+ R E N++ E LK E + LR L +E ++L
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENL 2397
Query: 318 SDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTAL 377
+++L+ + + E++ + + LQ K E + +++ +E LQ NER+ AL
Sbjct: 2398 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL 2457
Query: 378 QEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK------LSKENQTRAKESDFS 431
+ + Q +EC + + + L + ++E K S N + D
Sbjct: 2458 HNDQEACKAKEQNLSSQ-VECLE--LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 432 DTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS----LLKD---DLQGAQSEIEAK-QEIQ 483
L E+ S Q D++ L L++V L K+ +L+ E+E K Q +Q
Sbjct: 2515 QKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 484 HLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTE 543
L + E+ ++S + L + ++ ++ +V + T + LQ ++ + T
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 544 NLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWR 603
L+EE E EL +EI K + ++ ++ ELKK L+
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEI--------KSSKDQLKELTLENSELKK---SLDCMH 2682
Query: 604 KAASEYEKEITSLQNSFQLRCQQCEDQQR----EEATRLQGELEKLRKEWNALETECHSL 659
K E E ++ +QLR + E + + + + + E++ R++ + E S
Sbjct: 2683 KDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ 2742
Query: 660 KRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADL 719
K E LL S ++EL+NS K + ++ +L +M + NQ LK+++ R +
Sbjct: 2743 KLEIDLLKSS----KEELNNSLKATTQILEELKKTKMDNLKYVNQ---LKKENERAQGKM 2795
Query: 720 KTLLSKAENQAKDVQKEYEKTQTVLSELKLKFE------MTEQEKQSITDELKQCKNNLK 773
K L+ K +++E E Q LS+L+ E + + + +T E+K+ K L+
Sbjct: 2796 KLLI----KSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 90.9 bits (224), Expect = 4e-18
Identities = 129/581 (22%), Positives = 255/581 (43%), Gaps = 68/581 (11%)
Query: 238 KELIALQEDKHNYETTAKESLRRVLQ-EKIEVVRKLSEVERSLSNTEDECTHLKEMNERT 296
+ L +QE + + KE +R Q + +E L + ++ + N + E T+LK N+R
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAA--LQKQKQKVENEKTEGTNLKRENQRL 72
Query: 297 QEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQEL 356
E L +E++ ++ EG+ +++ + ++EL+ E+E +Q
Sbjct: 73 MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
Query: 357 QAKIEALQADND----FTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAV 412
Q+ +L N FT LT Q + SK ++ +E +K+L E KA+
Sbjct: 133 QSADVSLNPCNTPQKIFTTP-LTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE---VKAL 188
Query: 413 EETKLSK-------------ENQTRAKESDFSDTLSPSKEKSSDDTTDAQMD-------- 451
+ K S+ +Q + + +PS S+ T + D
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248
Query: 452 EQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKEL-IEAQELARTSKQKCFELQALL 510
EQ++ + + + K D A S HL +L + QEL + K EL+ L
Sbjct: 249 EQEVTPSRSTLQIGKRD---ANSSFFDNSSSPHLLDQLKAQNQEL----RNKINELELRL 301
Query: 511 EEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELL---SARDEI 567
+ K + QV + Q LQ QL++ ++ EK+ + RDEL+ + D+
Sbjct: 302 QGHEKEMKGQV----NKFQELQLQLEKAKVEL----IEKEKVLNKCRDELVRTTAQYDQA 353
Query: 568 LLLHQAAAKVASERDTDIASLQEELKKVRAELE-RWRKAASEYEKEITSLQNSFQLRCQQ 626
+ A + + D++ ++ + R LE + ++ E+++E++ Q SFQ Q+
Sbjct: 354 STKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
Query: 627 CEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLE 686
C + RL EL++ + N L+ E L L + L+ +++L +++
Sbjct: 414 CIQMK----ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 687 LTSDLSILQMSRKELENQVGSLK---EQHLRD----SADLKTL---LSKAENQAKDVQKE 736
+ L+ S +E++ + LK EQ R+ A+LK + L++++N A++++ +
Sbjct: 470 SQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Query: 737 YEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLRE 777
+T+L +L+ K + +QE ++LK +L+ R+
Sbjct: 530 NTSQETMLRDLQEK--INQQENSLTLEKLKLAVADLEKQRD 568
Score = 84.0 bits (206), Expect = 5e-16
Identities = 132/539 (24%), Positives = 227/539 (42%), Gaps = 71/539 (13%)
Query: 279 LSNTEDECTHLKEMNERTQEELRELA------NKYNGAVNEIKDLSDKLKVAEGKQEEIQ 332
L N ED + E + E LR L K +NE+K+L KL + +E+Q
Sbjct: 1763 LGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL-----QEVQ 1817
Query: 333 QKGQAEKK-ELQHKIDEMEEKEQELQAKIEALQADNDF------TNERLTALQEHLLSKS 385
+ E EL+ + E++++ +L K+E D+ T+E L + E KS
Sbjct: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKS 1877
Query: 386 G----GDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKS 441
GD ++ L VE L++ + K S E++ E+D + + K
Sbjct: 1878 SREDIGDNVAKVNDSWKERFLDVENELSR-IRSEKASIEHEALYLEADL-EVVQTEKLCL 1935
Query: 442 SDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQ 501
D + Q L E L+ V+ ++ L+G E+ + K+ +L+ K+
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRG---------ELDTMSKKTTALDQLSEKMKE 1986
Query: 502 KCFELQALLEEERKAYR---NQVEESTKQIQVLQAQLQRLHIDTENLRE-----EKDSEI 553
K EL++ E + +V+E T+ +Q L + + L D +L+E EKDS+
Sbjct: 1987 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQA 2046
Query: 554 TS-TRDELLSARDEILLLHQAAAKVASERDTDIASLQE---ELKKVRAELERWRKAASEY 609
S T+ EL ++I L++ + E ++ A L E E V LE E+
Sbjct: 2047 LSLTKCEL---ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF 2103
Query: 610 EKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSE 669
++S Q Q R +L+ +E K+ + + +REN L +
Sbjct: 2104 ALRLSSTQEEVH--------QLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 670 LQRQEKELHNSQKQS----LELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSK 725
++ E+EL S++ L+ + + ++ + ++E SLK L DL TL S+
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL----DLVTLRSE 2211
Query: 726 AENQAKDVQK---EYEKTQTVLSELKLKFEMTEQEKQSITDELK----QCKNNLKLLRE 777
EN K +Q+ + + +LS K E EQ + I +E K +N LK L E
Sbjct: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Score = 78.6 bits (192), Expect = 2e-14
Identities = 119/626 (19%), Positives = 246/626 (39%), Gaps = 70/626 (11%)
Query: 207 LIDEDRLLSRL--EVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQE 264
LI+++++L++ E++ Q + +L ++L L ED A ES R L++
Sbjct: 329 LIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA-ESARCSLEQ 387
Query: 265 KI-----EVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSD 319
KI E +LS +RS + EC +M R +EL++ N +N E+ L+
Sbjct: 388 KIKEKEKEFQEELSRQQRSFQTLDQECI---QMKARLTQELQQAKNMHNVLQAELDKLTS 444
Query: 320 KLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQE 379
+ E EE +QK ++ Q + KE EL+ +E ++ +N+ L+
Sbjct: 445 VKQQLENNLEEFKQKLCRAEQAFQ----ASQIKENELRRSMEEMKKENNL-------LKS 493
Query: 380 HLLSKSGGDCTF---IHQFIEC--QKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTL 434
H K+ C + +C Q + E K + + ++ Q + + + S TL
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL 553
Query: 435 SPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRK----ELI 490
K +D + L + + L D L + E +A L+K EL
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 491 EAQELARTSKQKCFELQALLEEERKAYRNQV--------------EESTKQIQVLQAQLQ 536
E + L K + +L +E E++ ++++ E ++++ L+ +
Sbjct: 614 EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 537 RLHIDTENLREEKDS---EITSTRDELLSARDEILLLHQAAAK-------VASERDTDIA 586
L ++ NL DS E+ + + + + + Q K S+ +
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 587 SLQEELKKVRAEL----ERWRKAASEYE--------KEITSLQNSFQLRCQQCEDQQ--- 631
L+ +L+ + E+ ++ +EYE K+ + + N R DQQ
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 632 REEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDL 691
+ GE + E + E + + +L + + E L + ++ + +L
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 692 SILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKF 751
L + E+E + ++ H A+ +SK + Q +T + L + +
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 752 EMTEQEKQSITDELKQCKNNLKLLRE 777
++ + ++ E+++ K + LL +
Sbjct: 914 QLLNDKVETEQAEIQELKKSNHLLED 939
Score = 77.8 bits (190), Expect = 4e-14
Identities = 131/581 (22%), Positives = 229/581 (39%), Gaps = 122/581 (20%)
Query: 146 LPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAIT----QEASD 201
L + ++K+ A + ++L L Q L+E+ H +L+ ++ L+R L I + A+
Sbjct: 2299 LRNSIEKLRARLEADEKKQLCVLQQ-LKESEHHADLLKGRVENLERELEIARTNQEHAAL 2357
Query: 202 TSWQALIDEDRLLSRLEVM-----GNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKE 256
+ + + + L +++E M G +L + +++L EL QE E
Sbjct: 2358 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII-NS 2416
Query: 257 SLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQ------------------- 297
S +LQEK + K+ E+S + E T LKE+NER
Sbjct: 2417 SFENILQEKEQ--EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 298 ------------EELRELANKY-------NGAVNEIKDLSDKLKVAEGKQEEIQQ-KGQA 337
+ L E N Y NG + E++D KL E K EEI + K Q
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL---EKKDEEISRLKNQI 2531
Query: 338 EKKE-LQHKIDEMEEKEQ--------------ELQAKIEALQADNDFTNERLTALQEHLL 382
+ +E L K+ ++E + Q EL+ KI+ LQ+ N + L LQ
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591
Query: 383 SKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRA-KESDFSDTLSPSKEKS 441
+ + + K VE +ET+L +E A K ++ + LS K +
Sbjct: 2592 NLENE-----LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRL 2646
Query: 442 SDDTT----DAQMDEQDLNEPLAKVSLLKDDLQ-----GAQSEIEAKQEIQHLRKELIEA 492
+ + + + + L E + S LK L + E + ++EI + L EA
Sbjct: 2647 AGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA 2706
Query: 493 QELAR---------------------TSKQKCFELQALLEEERKAYRNQVEESTKQIQVL 531
++ + TSK++C Q L + K+ + ++ S K +
Sbjct: 2707 EKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQI 2766
Query: 532 QAQLQRLHIDT---------ENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASER- 581
+L++ +D EN R + ++ + L EIL + + A E+
Sbjct: 2767 LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 582 ------DTDIASLQEELKKVRAELERWRKAASEYEKEITSL 616
DT + L E+K+++ LE K A EY + SL
Sbjct: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL 2867
Score = 70.9 bits (172), Expect = 5e-12
Identities = 145/697 (20%), Positives = 281/697 (40%), Gaps = 153/697 (21%)
Query: 204 WQALIDED---RLLSRLE--VMGNQLQA----CSKNQTEDSLRKELIALQ----EDKHNY 250
++AL+++ LLS LE V NQ CS Q E+ RKE + E+ +
Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555
Query: 251 ETTAKESLRRVLQEKIEVV-----RKLSEVERSLSNTEDECTHLKEM----NERTQEELR 301
++SL + L+EK+E +++ E+E+ LS+ E L++ NE+ Q++L
Sbjct: 1556 CEVYRQSLEK-LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLT 1614
Query: 302 ----ELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQ 357
E+ +K + + LS +L+VA +Q +G ID E +Q
Sbjct: 1615 SVTLEMESKLAAEKKQTEQLSLELEVAR-----LQLQGLDLSSRSLLGIDT----EDAIQ 1665
Query: 358 AKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKL 417
+ E+ + T+E +H +HQ + + + + K E +
Sbjct: 1666 GRNESCDISKEHTSETTERTPKH----------DVHQICDKDAQQDLNLDIEKITETGAV 1715
Query: 418 SKENQTRAKESDFSDTLSPSKEKSSDDTT----------------DAQMDEQDL------ 455
+ ++S ++ P ++K+ + D +++D+
Sbjct: 1716 KPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1775
Query: 456 -----NEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALL 510
NE L + +++D + +S + +E+ + L E Q + T + C EL+ ++
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-KLHLQEVQLM--TKIEACIELEKIV 1832
Query: 511 EEERKAYRNQVEESTKQIQVLQAQLQR------------LHIDT-------ENLREEKDS 551
E +K + E+ Q LQR +H D +N+ + DS
Sbjct: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDS 1892
Query: 552 ----------EITSTRDELLSARDEILLLHQ-----AAAKVASERDTD-----IASLQEE 591
E++ R E S E L L K+ E+D + I L+EE
Sbjct: 1893 WKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952
Query: 592 LKKVRAELERWRKAASEYEKEITSLQN---SFQLRCQQCEDQQREEATRLQGELEKLRKE 648
L V +E + R K+ T+L + + Q+ E Q E +Q +++++
Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEK 2012
Query: 649 WNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSL 708
L+T LSS++ K+ + Q++ L D L +++ ELENQ+ L
Sbjct: 2013 TELLQT-----------LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
Query: 709 ---KEQHLRDSADLKTLLSKAENQAKDV---------------------QKEYEKTQTVL 744
KE +++S L+ LS+++ + +V Q+E + + +
Sbjct: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
Query: 745 SELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNN 781
+L+++ E E+++ I ++LK+ + L++K N
Sbjct: 2122 EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2158
Score = 70.5 bits (171), Expect = 6e-12
Identities = 141/660 (21%), Positives = 268/660 (40%), Gaps = 123/660 (18%)
Query: 163 QELFQLSQYLQEALHREQMLEQKLA--TLQRLLAITQEASD------TSWQALIDEDRLL 214
+EL Q+ ++E L + + + Q T QR+ + ++ S + AL ++++ L
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 215 S----RLEVMGNQLQACSKNQ--TEDSLRK-----ELIALQE---------DKHNYET-- 252
++E ++Q K+ EDSL++ E ++L++ +K E
Sbjct: 914 QLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973
Query: 253 ----TAKESLRRVLQEKIEVVRK-------LSEVERSLSNTEDECTHLK----EMNERTQ 297
T KE + QEK+ +++K + E E+S+S D+ K + E T
Sbjct: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033
Query: 298 EELRELANKYNGAVNEIKDLSDKLK----VAEGKQEEIQQKGQAEKKELQHKIDEM---E 350
+L+ KY A + L L + E ++ E++Q +A KE Q + ++ E
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 351 EKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKK-------LI 403
E+ Q L ++E +Q +T Q + S++GG I E Q K L+
Sbjct: 1094 ERNQNLMLELETVQ---QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 404 VEGHLTKAVEETKLS-------------KENQTRAKESDFSDTLSPSKEKSSDDTTDAQM 450
E V +TK KE ++ + +F + ++ S D+ +AQ+
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
Query: 451 ---------DEQDLNEPLAKVSLLKDDLQGAQSEIEAK-------QEIQHLRKELIEAQE 494
E L E + L+ +LQ + ++E QEI L+ I+A+E
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 495 LARTSKQKCFELQ---ALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDS 551
+ + Q A L+ + N++ E K ++LQA+ L + + R E +
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
Query: 552 EITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQ------EELKKVRAELERWRKA 605
+E+ +E+ +L+ + + E DI + E+ A L+
Sbjct: 1331 ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE---- 1386
Query: 606 ASEYEKEITSLQNSFQLRCQQCEDQ---QREEATRLQGELEKLRKEWNALETECHSLKRE 662
++ YE +T Q+ + +++ + E L + ++ + + L+T SLK E
Sbjct: 1387 SNSYE-HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAE 1445
Query: 663 NVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTL 722
N++LS+ L+ + +L + LE E V SL + DS+ L +L
Sbjct: 1446 NLVLSTNLRNFQGDLVKEMQLGLE---------------EGLVPSLSSSCVPDSSSLSSL 1490
Score = 67.8 bits (164), Expect = 4e-11
Identities = 113/556 (20%), Positives = 218/556 (39%), Gaps = 68/556 (12%)
Query: 230 NQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHL 289
N + L +L A ++ N + L+ +E V K E++ L + E
Sbjct: 273 NSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEK 332
Query: 290 KEMNERTQEELRELANKYNGAVNEIKDLSDKLKV-----------AEGKQEEIQQKGQAE 338
+++ + ++EL +Y+ A + L KLK AE + ++QK + +
Sbjct: 333 EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
Query: 339 KKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIEC 398
+KE Q ++ + Q L E +Q T E A H + ++ E
Sbjct: 393 EKEFQEELSRQQRSFQTLDQ--ECIQMKARLTQELQQAKNMHNVLQA-----------EL 439
Query: 399 QKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEP 458
K V+ L +EE K+ RA+++ + + ++ + S M+E
Sbjct: 440 DKLTSVKQQLENNLEE---FKQKLCRAEQAFQASQIKENELRRS-------MEEMKKENN 489
Query: 459 LAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYR 518
L K Q A+ + E++++++ L ++Q A K K + +L + ++
Sbjct: 490 LLK----SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN 545
Query: 519 NQVEEST-KQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKV 577
Q T +++++ A L++ +++L ++++ I D+L E L A
Sbjct: 546 QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 578 ASERDTDIASLQEELKKVRAELERWR----KAASEYEKEITSLQNSFQLRCQQCEDQQRE 633
E EELK+ + W+ K ++ E E +LQ+ + C Q+
Sbjct: 606 KKE--------YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN-HLETCLKTQQI 656
Query: 634 EATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSI 693
++ + L + L E +L NVL S ++ + ++L + Q SD
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNL--HNVLDSKSVEVETQKLAYMELQQKAEFSD--- 711
Query: 694 LQMSRKELENQVGSLKEQHLRDSA-DLKTLLSKAENQA-------KDVQKEYEKTQTVLS 745
Q +KE+EN LK L DL+ L N+ +D+ EYE + +L
Sbjct: 712 -QKHQKEIENM--CLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 746 ELKLKFEMTEQEKQSI 761
E ++S+
Sbjct: 769 SKDASLVTNEDHQRSL 784
Score = 67.4 bits (163), Expect = 5e-11
Identities = 151/722 (20%), Positives = 299/722 (41%), Gaps = 132/722 (18%)
Query: 152 KVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQ---EASDTSWQALI 208
K N +++E+ + QE + R+ L++K+ + L + + +D Q
Sbjct: 513 KQCLNQSQNFAEEM-KAKNTSQETMLRD--LQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 209 DEDRLLSR---LEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEK 265
+D L R +E + ++L ++TE + L AL+ K YE KE K
Sbjct: 570 SQDLLKKREHHIEQLNDKL-----SKTEKESKALLSALELKKKEYEEL-KEEKTLFSCWK 623
Query: 266 IEVVRKLSEVERSLSNTEDECTHLK-----------EMNER--TQEELRE-LANKYNGAV 311
E + L+++E N + + HL+ E NER T E RE L+ +
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH 683
Query: 312 NEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTN 371
N + S +++ + E+QQK + ++ Q +I+ M K +L ++E L+
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE------- 736
Query: 372 ERLTALQEHLLSKSGGDC-TFIHQFIECQKKLIVEGH---LTKAVEETKLSKENQTRAKE 427
+L L ++ K C +H E + L+ +T + L +Q A
Sbjct: 737 HKLQLLSNEIMDKDR--CYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 428 SDFSDTLS-----PSK--------EKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQS 474
F++ + PS+ ++S ++ Q L L + DLQ
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 475 E-IEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQA 533
E ++ K EI+ + L++A+++ ++ + + + L+E+ A++N V E+ ++ +
Sbjct: 855 ELVQIKGEIE---ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
Query: 534 QLQRLH--IDTEN--LREEKDSE--ITSTRDELLSARDEILLLHQAAAKVASERDTDIAS 587
+LQ L+ ++TE ++E K S + + EL + + L + + + S +I
Sbjct: 912 ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEE 971
Query: 588 LQEE---LKKVRAEL-----------ERWRKAASEYEKEITSLQNSFQ----LRCQQCED 629
L +E LK++ A L E + E EK I+ L + ++ + Q+CE+
Sbjct: 972 LTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
Query: 630 ---------QQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKE---- 676
Q+ + A +LE L E +L C + K E L ++ +E
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSL---CENRKNELEQLKEAFAKEHQEFLTK 1088
Query: 677 LHNSQKQSLELTSDLSILQMSRKE---------------LENQVGSLKEQHLRDSADLKT 721
L +++++ L +L +Q + + L+ ++ +LKE+
Sbjct: 1089 LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ--------- 1139
Query: 722 LLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNN 781
+K + + D+ +E E+ V +K K E E + I + +K+ ++ R + N
Sbjct: 1140 --NKMQKEVNDLLQENEQLMKV---MKTKHECQNLESEPIRNSVKERESE----RNQCNF 1190
Query: 782 KP 783
KP
Sbjct: 1191 KP 1192
Score = 52.0 bits (123), Expect = 2e-06
Identities = 145/697 (20%), Positives = 277/697 (39%), Gaps = 122/697 (17%)
Query: 161 YSQELFQLSQYL-------QEALHREQMLEQKLATLQRLLAIT-------QEASDTSWQA 206
Y+ +L QL L QE+ ++ L+ +L T++ L + QE S
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 207 LIDEDRLLSRLEVMG-----NQLQACSKNQTEDSLRK-ELIA--LQEDKHNYETTAKESL 258
+ E++ +S + N CS T + L + E I LQ +K+ T +S
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Query: 259 RRVLQEKIEVVRKLSEV------ERSLSNTEDECTHLKEMNERTQEELRELANKYNGAV- 311
E I RK++E E + N + H + + + E E N+ +
Sbjct: 1326 ----SECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSL 1381
Query: 312 ------NEIKDLSDKLKVAEGKQEEIQQKG---QAEKKELQHKIDEMEEKEQELQAKIEA 362
N + L+ K + E+Q+K Q+E K L + +M K ELQ +++
Sbjct: 1382 APLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441
Query: 363 LQADN------------DFTNERLTALQEHLLS-------------KSGGDCTFIHQFIE 397
L+A+N D E L+E L+ S GD +F +E
Sbjct: 1442 LKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLE 1501
Query: 398 CQKKLIVEGHLTKAVEE----------TKLSKENQTRAKESDFSDTLSPSKEKSSDDTTD 447
+ + +L AV + L +EN TR KE+ + + +S +
Sbjct: 1502 QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTR-KETPSAPAKGVEELESLCEVYR 1560
Query: 448 AQMDEQDLNEPLAKVSLLKD-DLQGAQSEIEA-KQEIQHLRKELIEAQELARTSKQKCFE 505
+++ L E + ++K+ ++Q + + + +QE+ LRK+ + E +QK
Sbjct: 1561 QSLEK--LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE---QWQQKLTS 1615
Query: 506 LQALLEEERKAYRNQVEESTKQIQVLQAQLQRLH--------IDTENLREEKD------S 551
+ +E + A + Q E+ + +++V + QLQ L IDTE+ + ++
Sbjct: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISK 1675
Query: 552 EITSTRDELLSARDEILLLHQAAAKVA-SERDTDIASLQEE-LKKVRAELERWRKAASEY 609
E TS E D +HQ K A + + DI + E K E + + Y
Sbjct: 1676 EHTSETTERTPKHD----VHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNY 1731
Query: 610 EKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKL--RKEWNALETECHSLKRENVLLS 667
E +C + ++ L +++ + L+ EN+ L
Sbjct: 1732 EPPGEDKTQG----SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLL 1787
Query: 668 SELQRQEKELHNSQKQSLELTSDLSI--LQMSRK-----ELENQVGSLKEQHLRDSADLK 720
++ +++++ + + EL S L + +Q+ K ELE VG LK ++++DL
Sbjct: 1788 HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK----KENSDLS 1843
Query: 721 TLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQE 757
L +++ + E ++ + S+L++ + + +E
Sbjct: 1844 EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRE 1880
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,805,207
Number of Sequences: 37866
Number of extensions: 1272208
Number of successful extensions: 24537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 577
Number of HSP's successfully gapped in prelim test: 1290
Number of HSP's that attempted gapping in prelim test: 7856
Number of HSP's gapped (non-prelim): 7522
length of query: 811
length of database: 18,247,518
effective HSP length: 111
effective length of query: 700
effective length of database: 14,044,392
effective search space: 9831074400
effective search space used: 9831074400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.