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Search of human proteins with 56549666
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
(1038 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 2166 0.0
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 2077 0.0
gi|150010577 tyrosine kinase, non-receptor, 1 [Homo sapiens] 374 e-103
gi|29725609 epidermal growth factor receptor isoform a precursor... 215 2e-55
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 211 3e-54
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 211 3e-54
gi|4503787 fyn-related kinase [Homo sapiens] 210 6e-54
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 206 9e-53
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 202 2e-51
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 202 2e-51
gi|54792098 erbB-2 isoform b [Homo sapiens] 201 3e-51
gi|54792096 erbB-2 isoform a [Homo sapiens] 201 3e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 197 3e-50
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 197 3e-50
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 197 3e-50
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 197 3e-50
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 197 3e-50
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 195 2e-49
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 195 2e-49
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 194 3e-49
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 194 3e-49
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 194 3e-49
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 194 4e-49
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 194 5e-49
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 194 5e-49
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 193 8e-49
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 193 8e-49
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 193 8e-49
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 193 8e-49
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 193 8e-49
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens]
Length = 1038
Score = 2166 bits (5612), Expect = 0.0
Identities = 1038/1038 (100%), Positives = 1038/1038 (100%)
Query: 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 60
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
Sbjct: 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 60
Query: 61 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 120
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
Sbjct: 61 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 120
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 240
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
Sbjct: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 240
Query: 241 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 300
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
Sbjct: 241 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 300
Query: 301 SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 360
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
Sbjct: 301 SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 360
Query: 361 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA 420
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
Sbjct: 361 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA 420
Query: 421 ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD 480
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
Sbjct: 421 ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD 480
Query: 481 RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP 540
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
Sbjct: 481 RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP 540
Query: 541 GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL 600
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
Sbjct: 541 GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL 600
Query: 601 DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP 660
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
Sbjct: 601 DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP 660
Query: 661 AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA 720
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
Sbjct: 661 AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA 720
Query: 721 PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP 780
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
Sbjct: 721 PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP 780
Query: 781 REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA 840
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
Sbjct: 781 REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA 840
Query: 841 GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP 900
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
Sbjct: 841 GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP 900
Query: 901 APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD 960
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
Sbjct: 901 APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD 960
Query: 961 KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL 1020
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
Sbjct: 961 KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL 1020
Query: 1021 EQAGCHLLGSWGPAHHKR 1038
EQAGCHLLGSWGPAHHKR
Sbjct: 1021 EQAGCHLLGSWGPAHHKR 1038
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens]
Length = 1086
Score = 2077 bits (5382), Expect = 0.0
Identities = 1008/1053 (95%), Positives = 1008/1053 (95%), Gaps = 45/1053 (4%)
Query: 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 60
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
Sbjct: 64 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 123
Query: 61 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 120
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
Sbjct: 124 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 183
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
Sbjct: 184 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 243
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 240
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
Sbjct: 244 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 303
Query: 241 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 300
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
Sbjct: 304 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 363
Query: 301 SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 360
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
Sbjct: 364 SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 423
Query: 361 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA 420
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
Sbjct: 424 YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA 483
Query: 421 ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD 480
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
Sbjct: 484 ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD 543
Query: 481 RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVK---------------KPTYDPVSEDQ 525
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVK KPTYDPVSEDQ
Sbjct: 544 RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPAFFTQKPTYDPVSEDQ 603
Query: 526 DPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPC 585
DPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPC
Sbjct: 604 DPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPC 663
Query: 586 APSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDF 645
APSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDF
Sbjct: 664 APSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDF 723
Query: 646 EICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAE 705
EICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAE
Sbjct: 724 EICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAE 783
Query: 706 IFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEE 765
IFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEE
Sbjct: 784 IFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEE 843
Query: 766 TSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDP 825
TSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDP
Sbjct: 844 TSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDP 903
Query: 826 KYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEP 885
KYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEP
Sbjct: 904 KYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEP 963
Query: 886 TPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQ 945
TPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQ
Sbjct: 964 TPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQ 1023
Query: 946 RGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRP 1005
RGCPGDGPEAGRPADKIQM VEQLFGLGLRP
Sbjct: 1024 RGCPGDGPEAGRPADKIQM------------------------------VEQLFGLGLRP 1053
Query: 1006 RGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR 1038
RGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
Sbjct: 1054 RGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR 1086
>gi|150010577 tyrosine kinase, non-receptor, 1 [Homo sapiens]
Length = 661
Score = 374 bits (959), Expect = e-103
Identities = 210/448 (46%), Positives = 283/448 (63%), Gaps = 16/448 (3%)
Query: 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 60
M PE G+ WLL+LL ++QL Q++ + ++LNVTR HF++VK EDL+ IGMGRP QRRL
Sbjct: 1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS 60
Query: 61 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 120
EA+KR ++ K K+W+ K+ G F P H + T SP P EG L+ CL
Sbjct: 61 EALKRLRSGPKSKNWVYKILGG------FAPEHKEPTLPSDSPRHL-PEPEGGLK---CL 110
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK--PDVLSQPEAMDDFIREV 178
I E + E LG G FGVV RG W PSGK+V VAVK L+ P+ E + DF+REV
Sbjct: 111 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE-LGDFLREV 169
Query: 179 NAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH--FLLGTLSRYAVQV 236
+ M +L+H +++RL+G+VL P++MV ELAPLGSL RL L+ L + Q+
Sbjct: 170 SVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQL 229
Query: 237 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 296
A M YL ++ +HRDLA RNLLLA+ +K+ DFGL+R L YVM R +P+AW
Sbjct: 230 AGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAW 289
Query: 297 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 356
CAPESL+ FS ASD WMFGVTLWEMF+ G+EPW G+ IL +++ + RLPRP C
Sbjct: 290 CAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLC 348
Query: 357 PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVI 416
+ +Y++ ++CWA P DRP+F L L EA P++ ++D EP L ++ D ITVI
Sbjct: 349 SRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVI 408
Query: 417 EGRAENYWWRGQNTRTLCVGPFPRNVVT 444
EG ++ W+GQN RT VG FP + VT
Sbjct: 409 EGSPDSTIWKGQNGRTFKVGSFPASAVT 436
Score = 68.2 bits (165), Expect = 4e-11
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 18/156 (11%)
Query: 876 LREAQS-PEEPTPLPVPLLLPP--PSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGA 932
+R+A++ P+ P LP PP S+P P+ P+ P P+ K + PGA
Sbjct: 518 IRQARAVPQGPPGLPPR---PPLSSSSPQPSQPSRERLPWPKR----KPPHNHPMGMPGA 570
Query: 933 RPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQY 992
R + L PE R +++++ VHGVT +ECQ AL G V A +
Sbjct: 571 RKAAALSGGLLSD-------PELQRKIMEVELS-VHGVTHQECQTALGATGGDVVSAIRN 622
Query: 993 LKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 1028
LKV+QLF L R R +C ++LE + W+L A ++L
Sbjct: 623 LKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVL 658
Score = 33.1 bits (74), Expect = 1.4
Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 9/104 (8%)
Query: 697 PPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQV-----PPRVPIPPRPTR 751
PP+ Q + + R L++ S P P+ GG P++ P+ P P P R
Sbjct: 477 PPARGQRRNMPLERMKGISRSLESVL-SLGPRPTGGGSSPPEIRQARAVPQGP-PGLPPR 534
Query: 752 PHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPL 795
P + S P + + P P P P P+ G+R + L
Sbjct: 535 PPLSSSSPQPSQPSRERLPWPKRKP--PHNHPMGMPGARKAAAL 576
Score = 32.0 bits (71), Expect = 3.1
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 17/66 (25%)
Query: 754 VQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGK 813
+ L P P G G +SPP + + PQG PPG P PP SSSP
Sbjct: 502 LSLGPRPTG--------GGSSPPEIRQARAV-PQG--------PPGLPPRPPLSSSSPQP 544
Query: 814 TMPTTQ 819
+ P+ +
Sbjct: 545 SQPSRE 550
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 215 bits (548), Expect = 2e-55
Identities = 112/283 (39%), Positives = 173/283 (61%), Gaps = 6/283 (2%)
Query: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164
P P+GE P Q+L ++ E + + ++ LG G+FG V +G W P G+ V + V +
Sbjct: 691 PLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW-IPEGEKVKIPVAIKELRE 749
Query: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224
+ P+A + + E M S+D+ ++ RL G+ LT ++++T+L P G LLD +R+H+ +
Sbjct: 750 ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNI 809
Query: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284
L + VQ+A+GM YLE +R +HRDLAARN+L+ T VKI DFGL + L + Y
Sbjct: 810 GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 869
Query: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344
E KVP W A ES+ R ++H SD W +GVT+WE+ T+G +P+ G+ S+I ++
Sbjct: 870 -HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE 928
Query: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE 387
K GERLP+P C D+Y +MV+CW + RP F R+ ++E
Sbjct: 929 K-GERLPQPPICTIDVYMIMVKCWMIDADSRPKF---RELIIE 967
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 211 bits (537), Expect = 3e-54
Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)
Query: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164
P P+G P Q+ ++ E +L+ ++ LG G+FG V +G W P G+TV + V +
Sbjct: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
Query: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224
+ P+A +F+ E M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ +
Sbjct: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
Query: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284
L + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+
Sbjct: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
Query: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344
+ K+P W A E + R F+H SD W +GVT+WE+ T+G +P+ G+ +I ++
Sbjct: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
Query: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
K GERLP+P C D+Y VMV+CW + RP F L
Sbjct: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 211 bits (537), Expect = 3e-54
Identities = 112/277 (40%), Positives = 171/277 (61%), Gaps = 3/277 (1%)
Query: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDV 164
P P+G P Q+ ++ E +L+ ++ LG G+FG V +G W P G+TV + V +
Sbjct: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVAIKILNE 755
Query: 165 LSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF 224
+ P+A +F+ E M S+DH +L+RL GV L+P +++VT+L P G LL+ + +H+ +
Sbjct: 756 TTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI 815
Query: 225 LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHY 284
L + VQ+A+GM YLE +R +HRDLAARN+L+ + + VKI DFGL R L + D+
Sbjct: 816 GSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EGDEKE 874
Query: 285 VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKID 344
+ K+P W A E + R F+H SD W +GVT+WE+ T+G +P+ G+ +I ++
Sbjct: 875 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 934
Query: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
K GERLP+P C D+Y VMV+CW + RP F L
Sbjct: 935 K-GERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 210 bits (534), Expect = 6e-54
Identities = 118/296 (39%), Positives = 171/296 (57%), Gaps = 23/296 (7%)
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
I ++LL++LG G FG V G W+ T VAVK LKP + +DF+RE
Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWN----NTTPVAVKTLKPGSMDP----NDFLREAQI 280
Query: 181 MHSLDHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAE 238
M +L H LI+LY V L P+ ++TEL GSL + L+ G + L A QVA
Sbjct: 281 MKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
Query: 239 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALP-QNDDHYVMQEHRKVPFAWC 297
GM YLES+ +IHRDLAARN+L+ ++ K+ DFGL R N+D Y + K+P W
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
Query: 298 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP 357
APE++++ FS SD W FG+ L+E+ TYG+ P+ G+ G+Q++ + + RLP+P +CP
Sbjct: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQML-AQNYRLPQPSNCP 459
Query: 358 QDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVI 413
Q YN+M++CW +P++RPTF LR L+D+ E D + N+ I
Sbjct: 460 QQFYNIMLECWNAEPKERPTFETLR-----------WKLEDYFETDSSYSDANNFI 504
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 206 bits (524), Expect = 9e-53
Identities = 105/266 (39%), Positives = 165/266 (62%), Gaps = 12/266 (4%)
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
I + L+L +KLG G FG V W A K VAVK +KP +S ++ F+ E N
Sbjct: 257 IPRESLKLEKKLGAGQFGEV----WMATYNKHTKVAVKTMKPGSMS----VEAFLAEANV 308
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 239
M +L H L++L+ VV P+ ++TE GSLLD L+ +G L L ++ Q+AEG
Sbjct: 309 MKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEG 368
Query: 240 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299
M ++E + +IHRDL A N+L++ + KI DFGL R + N+ Y +E K P W AP
Sbjct: 369 MAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE--YTAREGAKFPIKWTAP 426
Query: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359
E++ +F+ SD W FG+ L E+ TYG+ P+ G++ +++ +++ G R+PRPE+CP++
Sbjct: 427 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER-GYRMPRPENCPEE 485
Query: 360 IYNVMVQCWAHKPEDRPTFVALRDFL 385
+YN+M++CW ++PE+RPTF ++ L
Sbjct: 486 LYNIMMRCWKNRPEERPTFEYIQSVL 511
Score = 30.8 bits (68), Expect = 6.9
Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 395 ALQDFE--EPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQ 452
AL D+E + L Q D + V+E E WW+ ++ T G P N V V L +
Sbjct: 85 ALYDYEAIHHEDLSFQKGDQMVVLEESGE--WWKARSLATRKEGYIPSNYVARVDSLETE 142
Query: 453 D 453
+
Sbjct: 143 E 143
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 202 bits (513), Expect = 2e-51
Identities = 98/251 (39%), Positives = 153/251 (60%), Gaps = 5/251 (1%)
Query: 132 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 191
+G+G FG V +G + +P ++VA+K K + + F++E M DH ++++
Sbjct: 450 IGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQEALTMRQFDHPHIVK 507
Query: 192 LYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHR 251
L GV+ P+ ++ EL LG L L+ + L +L YA Q++ + YLESKRF+HR
Sbjct: 508 LIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHR 567
Query: 252 DLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHAS 311
D+AARN+L+++ D VK+GDFGL R + D Y K+P W APES+ R F+ AS
Sbjct: 568 DIAARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSAS 625
Query: 312 DTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHK 371
D WMFGV +WE+ +G +P+ G+ + ++ +I+ GERLP P +CP +Y++M +CWA+
Sbjct: 626 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE-NGERLPMPPNCPPTLYSLMTKCWAYD 684
Query: 372 PEDRPTFVALR 382
P RP F L+
Sbjct: 685 PSRRPRFTELK 695
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 202 bits (513), Expect = 2e-51
Identities = 98/251 (39%), Positives = 153/251 (60%), Gaps = 5/251 (1%)
Query: 132 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 191
+G+G FG V +G + +P ++VA+K K + + F++E M DH ++++
Sbjct: 428 IGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQEALTMRQFDHPHIVK 485
Query: 192 LYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHR 251
L GV+ P+ ++ EL LG L L+ + L +L YA Q++ + YLESKRF+HR
Sbjct: 486 LIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHR 545
Query: 252 DLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHAS 311
D+AARN+L+++ D VK+GDFGL R + D Y K+P W APES+ R F+ AS
Sbjct: 546 DIAARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSAS 603
Query: 312 DTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHK 371
D WMFGV +WE+ +G +P+ G+ + ++ +I+ GERLP P +CP +Y++M +CWA+
Sbjct: 604 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE-NGERLPMPPNCPPTLYSLMTKCWAYD 662
Query: 372 PEDRPTFVALR 382
P RP F L+
Sbjct: 663 PSRRPRFTELK 673
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 201 bits (511), Expect = 3e-51
Identities = 111/276 (40%), Positives = 167/276 (60%), Gaps = 7/276 (2%)
Query: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKP 162
P P+G P Q+ ++ E +LR ++ LG G+FG V +G W P G+ V VA+K L+
Sbjct: 669 PLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVAIKVLRE 727
Query: 163 DVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG 222
+ + P+A + + E M + + RL G+ LT +++VT+L P G LLD +R+++G
Sbjct: 728 N--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG 785
Query: 223 HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDD 282
L + +Q+A+GM YLE R +HRDLAARN+L+ + + VKI DFGL R L ++
Sbjct: 786 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDET 845
Query: 283 HYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHK 342
Y + KVP W A ES+ R F+H SD W +GVT+WE+ T+G +P+ G+ +I
Sbjct: 846 EY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL 904
Query: 343 IDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 378
++K GERLP+P C D+Y +MV+CW E RP F
Sbjct: 905 LEK-GERLPQPPICTIDVYMIMVKCWMIDSECRPRF 939
Score = 39.7 bits (91), Expect = 0.015
Identities = 44/156 (28%), Positives = 59/156 (37%), Gaps = 24/156 (15%)
Query: 698 PSSAQTAEIFQA-LQQECMRQLQA-PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQ 755
PS +++F L + LQ+ P P+P D P VP+P T +V
Sbjct: 1047 PSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSED------PTVPLPSE-TDGYVA 1099
Query: 756 LSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTM 815
P E +Q P V P+ P +G P P P + L + SPGK
Sbjct: 1100 PLTCSPQPEYVNQ-------PDVRPQPPSPREG---PLPAARPAGATLERPKTLSPGKNG 1149
Query: 816 PTTQSFA-----SDPKYATPQVIQAPGPRAGPCILP 846
FA +P+Y TPQ AP P P P
Sbjct: 1150 VVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSP 1185
Score = 32.3 bits (72), Expect = 2.4
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 33/124 (26%)
Query: 728 SPSPGGDDKPQVPPRVPIPPRPTRPHVQ-----------LSPAPPGE-EETSQWPGPASP 775
SP P ++P V P+ P P P + LSP G ++ + G
Sbjct: 1104 SPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVEN 1163
Query: 776 PRVPPREPLSPQGSRTPSPLVPPGSSPL----------PPRLSSSPG--KTMPTTQSFAS 823
P E L+PQG P P PP SP PP + P K PT A
Sbjct: 1164 P-----EYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPT----AE 1214
Query: 824 DPKY 827
+P+Y
Sbjct: 1215 NPEY 1218
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 201 bits (511), Expect = 3e-51
Identities = 111/276 (40%), Positives = 167/276 (60%), Gaps = 7/276 (2%)
Query: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKP 162
P P+G P Q+ ++ E +LR ++ LG G+FG V +G W P G+ V VA+K L+
Sbjct: 699 PLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVAIKVLRE 757
Query: 163 DVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG 222
+ + P+A + + E M + + RL G+ LT +++VT+L P G LLD +R+++G
Sbjct: 758 N--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG 815
Query: 223 HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDD 282
L + +Q+A+GM YLE R +HRDLAARN+L+ + + VKI DFGL R L ++
Sbjct: 816 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDET 875
Query: 283 HYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHK 342
Y + KVP W A ES+ R F+H SD W +GVT+WE+ T+G +P+ G+ +I
Sbjct: 876 EY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL 934
Query: 343 IDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 378
++K GERLP+P C D+Y +MV+CW E RP F
Sbjct: 935 LEK-GERLPQPPICTIDVYMIMVKCWMIDSECRPRF 969
Score = 39.7 bits (91), Expect = 0.015
Identities = 44/156 (28%), Positives = 59/156 (37%), Gaps = 24/156 (15%)
Query: 698 PSSAQTAEIFQA-LQQECMRQLQA-PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQ 755
PS +++F L + LQ+ P P+P D P VP+P T +V
Sbjct: 1077 PSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSED------PTVPLPSE-TDGYVA 1129
Query: 756 LSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTM 815
P E +Q P V P+ P +G P P P + L + SPGK
Sbjct: 1130 PLTCSPQPEYVNQ-------PDVRPQPPSPREG---PLPAARPAGATLERPKTLSPGKNG 1179
Query: 816 PTTQSFA-----SDPKYATPQVIQAPGPRAGPCILP 846
FA +P+Y TPQ AP P P P
Sbjct: 1180 VVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSP 1215
Score = 32.3 bits (72), Expect = 2.4
Identities = 35/124 (28%), Positives = 46/124 (37%), Gaps = 33/124 (26%)
Query: 728 SPSPGGDDKPQVPPRVPIPPRPTRPHVQ-----------LSPAPPGE-EETSQWPGPASP 775
SP P ++P V P+ P P P + LSP G ++ + G
Sbjct: 1134 SPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVEN 1193
Query: 776 PRVPPREPLSPQGSRTPSPLVPPGSSPL----------PPRLSSSPG--KTMPTTQSFAS 823
P E L+PQG P P PP SP PP + P K PT A
Sbjct: 1194 P-----EYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPT----AE 1244
Query: 824 DPKY 827
+P+Y
Sbjct: 1245 NPEY 1248
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 197 bits (502), Expect = 3e-50
Identities = 110/256 (42%), Positives = 147/256 (57%), Gaps = 12/256 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 324
Query: 185 DHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV L PP +VTE P G+LLD LR+ + + Y A Q++ M Y
Sbjct: 325 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 384
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ +VK+ DFGL R + D Y K P W APESL
Sbjct: 385 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 442
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
TFS SD W FGV LWE+ TYG P+ G++ SQ+ ++K G R+ +PE CP +Y
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYE 501
Query: 363 VMVQCWAHKPEDRPTF 378
+M CW P DRP+F
Sbjct: 502 LMRACWKWSPADRPSF 517
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 197 bits (502), Expect = 3e-50
Identities = 110/256 (42%), Positives = 147/256 (57%), Gaps = 12/256 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 287 DITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 339
Query: 185 DHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV L PP +VTE P G+LLD LR+ + + Y A Q++ M Y
Sbjct: 340 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 399
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ +VK+ DFGL R + D Y K P W APESL
Sbjct: 400 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 457
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
TFS SD W FGV LWE+ TYG P+ G++ SQ+ ++K G R+ +PE CP +Y
Sbjct: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYE 516
Query: 363 VMVQCWAHKPEDRPTF 378
+M CW P DRP+F
Sbjct: 517 LMRACWKWSPADRPSF 532
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 197 bits (502), Expect = 3e-50
Identities = 110/256 (42%), Positives = 147/256 (57%), Gaps = 12/256 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 266 DITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 318
Query: 185 DHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV L PP +VTE P G+LLD LR+ + + Y A Q++ M Y
Sbjct: 319 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 378
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ +VK+ DFGL R + D Y K P W APESL
Sbjct: 379 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 436
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
TFS SD W FGV LWE+ TYG P+ G++ SQ+ ++K G R+ +PE CP +Y
Sbjct: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYE 495
Query: 363 VMVQCWAHKPEDRPTF 378
+M CW P DRP+F
Sbjct: 496 LMRACWKWSPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 197 bits (502), Expect = 3e-50
Identities = 110/256 (42%), Positives = 147/256 (57%), Gaps = 12/256 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 272 DITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 324
Query: 185 DHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV L PP +VTE P G+LLD LR+ + + Y A Q++ M Y
Sbjct: 325 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 384
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ +VK+ DFGL R + D Y K P W APESL
Sbjct: 385 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 442
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
TFS SD W FGV LWE+ TYG P+ G++ SQ+ ++K G R+ +PE CP +Y
Sbjct: 443 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYE 501
Query: 363 VMVQCWAHKPEDRPTF 378
+M CW P DRP+F
Sbjct: 502 LMRACWKWSPADRPSF 517
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 197 bits (502), Expect = 3e-50
Identities = 110/256 (42%), Positives = 147/256 (57%), Gaps = 12/256 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 251 DITMKHKLGGGQYGEVYVGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 303
Query: 185 DHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV L PP +VTE P G+LLD LR+ + + Y A Q++ M Y
Sbjct: 304 KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 363
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ +VK+ DFGL R + D Y K P W APESL
Sbjct: 364 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 421
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
TFS SD W FGV LWE+ TYG P+ G++ SQ+ ++K G R+ +PE CP +Y
Sbjct: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK-GYRMEQPEGCPPKVYE 480
Query: 363 VMVQCWAHKPEDRPTF 378
+M CW P DRP+F
Sbjct: 481 LMRACWKWSPADRPSF 496
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 195 bits (496), Expect = 2e-49
Identities = 115/304 (37%), Positives = 166/304 (54%), Gaps = 12/304 (3%)
Query: 83 KRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRR 142
++L A + H R T+ P L I + LRL KLG G FG V
Sbjct: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWM 286
Query: 143 GEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK 202
G W+ T VA+K LKP +S PEA F++E M L H L++LY VV P+
Sbjct: 287 GTWNG----TTRVAIKTLKPGTMS-PEA---FLQEAQVMKKLRHEKLVQLYAVVSEEPIY 338
Query: 203 MVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA 261
+VTE GSLLD L+ G +L L L A Q+A GM Y+E ++HRDL A N+L+
Sbjct: 339 IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 398
Query: 262 TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLW 321
+ K+ DFGL R + N+ Y ++ K P W APE+ F+ SD W FG+ L
Sbjct: 399 ENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456
Query: 322 EMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ ++++M QCW +PE+RPTF L
Sbjct: 457 ELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515
Query: 382 RDFL 385
+ FL
Sbjct: 516 QAFL 519
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 195 bits (496), Expect = 2e-49
Identities = 115/304 (37%), Positives = 166/304 (54%), Gaps = 12/304 (3%)
Query: 83 KRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRR 142
++L A + H R T+ P L I + LRL KLG G FG V
Sbjct: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWM 286
Query: 143 GEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK 202
G W+ T VA+K LKP +S PEA F++E M L H L++LY VV P+
Sbjct: 287 GTWNG----TTRVAIKTLKPGTMS-PEA---FLQEAQVMKKLRHEKLVQLYAVVSEEPIY 338
Query: 203 MVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA 261
+VTE GSLLD L+ G +L L L A Q+A GM Y+E ++HRDL A N+L+
Sbjct: 339 IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 398
Query: 262 TRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLW 321
+ K+ DFGL R + N+ Y ++ K P W APE+ F+ SD W FG+ L
Sbjct: 399 ENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456
Query: 322 EMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ ++++M QCW +PE+RPTF L
Sbjct: 457 ELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515
Query: 382 RDFL 385
+ FL
Sbjct: 516 QAFL 519
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 194 bits (494), Expect = 3e-49
Identities = 107/266 (40%), Positives = 155/266 (58%), Gaps = 12/266 (4%)
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
I + L+L+++LG+G FG V G W+ VA+K LKP +S PE+ F+ E
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNG----NTKVAIKTLKPGTMS-PES---FLEEAQI 317
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 239
M L H L++LY VV P+ +VTE GSLLD L+ +G L L L A QVA G
Sbjct: 318 MKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 377
Query: 240 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299
M Y+E +IHRDL + N+L+ + KI DFGL R + N+ Y ++ K P W AP
Sbjct: 378 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE--YTARQGAKFPIKWTAP 435
Query: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359
E+ F+ SD W FG+ L E+ T G+ P+ G+N ++L ++++ G R+P P+DCP
Sbjct: 436 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER-GYRMPCPQDCPIS 494
Query: 360 IYNVMVQCWAHKPEDRPTFVALRDFL 385
++ +M+ CW PE+RPTF L+ FL
Sbjct: 495 LHELMIHCWKKDPEERPTFEYLQSFL 520
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 194 bits (494), Expect = 3e-49
Identities = 110/289 (38%), Positives = 164/289 (56%), Gaps = 13/289 (4%)
Query: 99 RKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVK 158
R+ A P + P I + ++L+++LG G FG V G ++ + VAVK
Sbjct: 199 RRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYN----NSTKVAVK 254
Query: 159 CLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRL 217
LKP +S + F+ E N M +L H L+RLY VV P+ ++TE GSLLD L
Sbjct: 255 TLKPGTMS----VQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFL 310
Query: 218 RKHQG-HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA 276
+ +G LL L ++ Q+AEGM Y+E K +IHRDL A N+L++ + KI DFGL R
Sbjct: 311 KSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARV 370
Query: 277 LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG 336
+ D+ Y +E K P W APE++ F+ SD W FG+ L+E+ TYG+ P+ G
Sbjct: 371 I--EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 428
Query: 337 SQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL 385
+ ++ + +G R+PR E+CP ++Y++M CW K E+RPTF L+ L
Sbjct: 429 ADVMTAL-SQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVL 476
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 194 bits (494), Expect = 3e-49
Identities = 110/289 (38%), Positives = 164/289 (56%), Gaps = 13/289 (4%)
Query: 99 RKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVK 158
R+ A P + P I + ++L+++LG G FG V G ++ + VAVK
Sbjct: 220 RRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYN----NSTKVAVK 275
Query: 159 CLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRL 217
LKP +S + F+ E N M +L H L+RLY VV P+ ++TE GSLLD L
Sbjct: 276 TLKPGTMS----VQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFL 331
Query: 218 RKHQG-HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA 276
+ +G LL L ++ Q+AEGM Y+E K +IHRDL A N+L++ + KI DFGL R
Sbjct: 332 KSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARV 391
Query: 277 LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG 336
+ D+ Y +E K P W APE++ F+ SD W FG+ L+E+ TYG+ P+ G
Sbjct: 392 I--EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 449
Query: 337 SQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL 385
+ ++ + +G R+PR E+CP ++Y++M CW K E+RPTF L+ L
Sbjct: 450 ADVMTAL-SQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVL 497
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 194 bits (493), Expect = 4e-49
Identities = 113/280 (40%), Positives = 158/280 (56%), Gaps = 14/280 (5%)
Query: 108 PAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQ 167
PA + P I + LRL+ KLG G FG V G + + VA+K LK +S
Sbjct: 223 PAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYK----NNMKVAIKTLKEGTMS- 277
Query: 168 PEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-L 226
PEA F+ E N M +L H L+RLY VV P+ +VTE G LLD L+ +G L L
Sbjct: 278 PEA---FLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSL 334
Query: 227 GTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVM 286
L + Q+AEGM Y+E IHRDL A N+L++ KI DFGL R + D Y
Sbjct: 335 PRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII---DSEYTA 391
Query: 287 QEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE 346
QE K P W APE++ F+ +D W FGV L E+ TYG+ P+ G++ +++ +++
Sbjct: 392 QEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLER- 450
Query: 347 GERLPRPEDCPQDIY-NVMVQCWAHKPEDRPTFVALRDFL 385
G R+PRP+ CP ++Y V+ +CW +PE+RPTF L+ L
Sbjct: 451 GYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVL 490
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 194 bits (492), Expect = 5e-49
Identities = 107/259 (41%), Positives = 146/259 (56%), Gaps = 12/259 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 293
Query: 185 DHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV PP ++TE G+LLD LR+ + + Y A Q++ M Y
Sbjct: 294 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 353
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ LVK+ DFGL R + D Y K P W APESL
Sbjct: 354 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 411
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
FS SD W FGV LWE+ TYG P+ G++ SQ+ ++K+ R+ RPE CP+ +Y
Sbjct: 412 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD-YRMERPEGCPEKVYE 470
Query: 363 VMVQCWAHKPEDRPTFVAL 381
+M CW P DRP+F +
Sbjct: 471 LMRACWQWNPSDRPSFAEI 489
Score = 35.4 bits (80), Expect = 0.28
Identities = 68/261 (26%), Positives = 88/261 (33%), Gaps = 62/261 (23%)
Query: 730 SPGGDDKPQVPPRVPIPPRPTRPHVQLSPAP--PGEEETSQWPGPASPPRVPPREPLSPQ 787
SPG PP + P+P R V ++PA P +EE + +P P P S
Sbjct: 805 SPGSS-----PPN--LTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKA 857
Query: 788 GSRTPSPLVPPGSSPLP---------PRLSSSPG---------KTMPTTQSFASDPKYAT 829
GS P G+S P S SPG K P AS K A
Sbjct: 858 GSGAPG-----GTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGK-AG 911
Query: 830 PQVIQAPGPR-AGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPL 888
+ Q+P AG +L G K +T S ++ + P E
Sbjct: 912 GKPSQSPSQEAAGEAVL-----GAKTKAT---------SLVDAVNSDAAKPSQPGEGLKK 957
Query: 889 PV------PLLLPPPSTPAPAAPTATVRPMPQAAL---DPKAN-----FSTNNSNPGARP 934
PV P P TP AP + P +AL P + ST S R
Sbjct: 958 PVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQ 1017
Query: 935 PPPRATARLPQRGCPGDGPEA 955
PP R + +G D EA
Sbjct: 1018 PPERIASGAITKGVVLDSTEA 1038
Score = 33.1 bits (74), Expect = 1.4
Identities = 45/196 (22%), Positives = 61/196 (31%), Gaps = 50/196 (25%)
Query: 599 LLDETPPQSPTRALPRPLHPTPVVDWDARPLP------------PPPAYDDVAQDEDDFE 646
+++ +P SP P+PL V A LP P A + V
Sbjct: 801 IMESSPGSSPPNLTPKPLRRQVTVA-PASGLPHKEEAGKGSALGTPAAAEPVTP------ 853
Query: 647 ICSINSTLVGAGVPAGPSQGQTNYAFVPEQ-------------------ARPPPPLEDNL 687
++ G+G P G S+G + V A PPPP
Sbjct: 854 -----TSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAAS-- 906
Query: 688 FLPPQGGGKP---PSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVP 744
+ GGKP PS E + + + A A PG K V P P
Sbjct: 907 --AGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATP 964
Query: 745 IPPRPTRPHVQLSPAP 760
P +SPAP
Sbjct: 965 KPQSAKPSGTPISPAP 980
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 194 bits (492), Expect = 5e-49
Identities = 107/259 (41%), Positives = 146/259 (56%), Gaps = 12/259 (4%)
Query: 125 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 184
D+ + KLG G +G V G W S ++VAVK LK D + +++F++E M +
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYS---LTVAVKTLKEDTME----VEEFLKEAAVMKEI 312
Query: 185 DHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY-AVQVAEGMGY 242
H NL++L GV PP ++TE G+LLD LR+ + + Y A Q++ M Y
Sbjct: 313 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 372
Query: 243 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 302
LE K FIHRDLAARN L+ LVK+ DFGL R + D Y K P W APESL
Sbjct: 373 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL 430
Query: 303 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 362
FS SD W FGV LWE+ TYG P+ G++ SQ+ ++K+ R+ RPE CP+ +Y
Sbjct: 431 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD-YRMERPEGCPEKVYE 489
Query: 363 VMVQCWAHKPEDRPTFVAL 381
+M CW P DRP+F +
Sbjct: 490 LMRACWQWNPSDRPSFAEI 508
Score = 35.4 bits (80), Expect = 0.28
Identities = 68/261 (26%), Positives = 88/261 (33%), Gaps = 62/261 (23%)
Query: 730 SPGGDDKPQVPPRVPIPPRPTRPHVQLSPAP--PGEEETSQWPGPASPPRVPPREPLSPQ 787
SPG PP + P+P R V ++PA P +EE + +P P P S
Sbjct: 824 SPGSS-----PPN--LTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKA 876
Query: 788 GSRTPSPLVPPGSSPLP---------PRLSSSPG---------KTMPTTQSFASDPKYAT 829
GS P G+S P S SPG K P AS K A
Sbjct: 877 GSGAPG-----GTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGK-AG 930
Query: 830 PQVIQAPGPR-AGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPL 888
+ Q+P AG +L G K +T S ++ + P E
Sbjct: 931 GKPSQSPSQEAAGEAVL-----GAKTKAT---------SLVDAVNSDAAKPSQPGEGLKK 976
Query: 889 PV------PLLLPPPSTPAPAAPTATVRPMPQAAL---DPKAN-----FSTNNSNPGARP 934
PV P P TP AP + P +AL P + ST S R
Sbjct: 977 PVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQ 1036
Query: 935 PPPRATARLPQRGCPGDGPEA 955
PP R + +G D EA
Sbjct: 1037 PPERIASGAITKGVVLDSTEA 1057
Score = 33.1 bits (74), Expect = 1.4
Identities = 45/196 (22%), Positives = 61/196 (31%), Gaps = 50/196 (25%)
Query: 599 LLDETPPQSPTRALPRPLHPTPVVDWDARPLP------------PPPAYDDVAQDEDDFE 646
+++ +P SP P+PL V A LP P A + V
Sbjct: 820 IMESSPGSSPPNLTPKPLRRQVTVA-PASGLPHKEEAGKGSALGTPAAAEPVTP------ 872
Query: 647 ICSINSTLVGAGVPAGPSQGQTNYAFVPEQ-------------------ARPPPPLEDNL 687
++ G+G P G S+G + V A PPPP
Sbjct: 873 -----TSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAAS-- 925
Query: 688 FLPPQGGGKP---PSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVP 744
+ GGKP PS E + + + A A PG K V P P
Sbjct: 926 --AGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATP 983
Query: 745 IPPRPTRPHVQLSPAP 760
P +SPAP
Sbjct: 984 KPQSAKPSGTPISPAP 999
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 193 bits (490), Expect = 8e-49
Identities = 105/266 (39%), Positives = 157/266 (59%), Gaps = 12/266 (4%)
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
+ + L+L+E+LG G FG V G ++ + VAVK LK +S D F+ E N
Sbjct: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHT----KVAVKSLKQGSMSP----DAFLAEANL 291
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 239
M L H+ L+RLY VV P+ ++TE GSL+D L+ G L + L A Q+AEG
Sbjct: 292 MKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEG 351
Query: 240 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299
M ++E + +IHRDL A N+L++ KI DFGL R + N+ Y +E K P W AP
Sbjct: 352 MAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNE--YTAREGAKFPIKWTAP 409
Query: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359
E++ TF+ SD W FG+ L E+ T+G+ P+ G+ +++ +++ G R+ RP++CP++
Sbjct: 410 EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER-GYRMVRPDNCPEE 468
Query: 360 IYNVMVQCWAHKPEDRPTFVALRDFL 385
+Y +M CW +PEDRPTF LR L
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVL 494
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 193 bits (490), Expect = 8e-49
Identities = 105/266 (39%), Positives = 157/266 (59%), Gaps = 12/266 (4%)
Query: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 180
+ + L+L+E+LG G FG V G ++ + VAVK LK +S D F+ E N
Sbjct: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHT----KVAVKSLKQGSMSP----DAFLAEANL 291
Query: 181 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 239
M L H+ L+RLY VV P+ ++TE GSL+D L+ G L + L A Q+AEG
Sbjct: 292 MKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEG 351
Query: 240 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 299
M ++E + +IHRDL A N+L++ KI DFGL R + N+ Y +E K P W AP
Sbjct: 352 MAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNE--YTAREGAKFPIKWTAP 409
Query: 300 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359
E++ TF+ SD W FG+ L E+ T+G+ P+ G+ +++ +++ G R+ RP++CP++
Sbjct: 410 EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER-GYRMVRPDNCPEE 468
Query: 360 IYNVMVQCWAHKPEDRPTFVALRDFL 385
+Y +M CW +PEDRPTF LR L
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVL 494
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 193 bits (490), Expect = 8e-49
Identities = 101/282 (35%), Positives = 161/282 (57%), Gaps = 14/282 (4%)
Query: 100 KTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKC 159
+T PGGP I +D+ L LG+G FG V G + G+ ++VAVK
Sbjct: 408 ETLRRPGGPQYG---------IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKT 458
Query: 160 LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRK 219
K D + + F+ E M +LDH ++++L G++ P ++ EL P G L L +
Sbjct: 459 CKKDCTLDNK--EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLER 516
Query: 220 HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ 279
++ + TL Y++Q+ + M YLES +HRD+A RN+L+A+ + VK+GDFGL R +
Sbjct: 517 NKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-- 574
Query: 280 NDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI 339
D+ Y ++P W +PES+ R F+ ASD WMF V +WE+ ++G++P+ L +
Sbjct: 575 EDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDV 634
Query: 340 LHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
+ ++K G+RLP+P+ CP +Y +M +CW + P DRP F L
Sbjct: 635 IGVLEK-GDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 193 bits (490), Expect = 8e-49
Identities = 101/282 (35%), Positives = 161/282 (57%), Gaps = 14/282 (4%)
Query: 100 KTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKC 159
+T PGGP I +D+ L LG+G FG V G + G+ ++VAVK
Sbjct: 408 ETLRRPGGPQYG---------IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKT 458
Query: 160 LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRK 219
K D + + F+ E M +LDH ++++L G++ P ++ EL P G L L +
Sbjct: 459 CKKDCTLDNK--EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLER 516
Query: 220 HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ 279
++ + TL Y++Q+ + M YLES +HRD+A RN+L+A+ + VK+GDFGL R +
Sbjct: 517 NKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-- 574
Query: 280 NDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI 339
D+ Y ++P W +PES+ R F+ ASD WMF V +WE+ ++G++P+ L +
Sbjct: 575 EDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDV 634
Query: 340 LHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
+ ++K G+RLP+P+ CP +Y +M +CW + P DRP F L
Sbjct: 635 IGVLEK-GDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 193 bits (490), Expect = 8e-49
Identities = 101/282 (35%), Positives = 161/282 (57%), Gaps = 14/282 (4%)
Query: 100 KTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKC 159
+T PGGP I +D+ L LG+G FG V G + G+ ++VAVK
Sbjct: 408 ETLRRPGGPQYG---------IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKT 458
Query: 160 LKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRK 219
K D + + F+ E M +LDH ++++L G++ P ++ EL P G L L +
Sbjct: 459 CKKDCTLDNK--EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLER 516
Query: 220 HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ 279
++ + TL Y++Q+ + M YLES +HRD+A RN+L+A+ + VK+GDFGL R +
Sbjct: 517 NKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-- 574
Query: 280 NDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI 339
D+ Y ++P W +PES+ R F+ ASD WMF V +WE+ ++G++P+ L +
Sbjct: 575 EDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDV 634
Query: 340 LHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 381
+ ++K G+RLP+P+ CP +Y +M +CW + P DRP F L
Sbjct: 635 IGVLEK-GDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,693,621
Number of Sequences: 37866
Number of extensions: 3820566
Number of successful extensions: 51111
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 937
Number of HSP's successfully gapped in prelim test: 2235
Number of HSP's that attempted gapping in prelim test: 19898
Number of HSP's gapped (non-prelim): 16871
length of query: 1038
length of database: 18,247,518
effective HSP length: 112
effective length of query: 926
effective length of database: 14,006,526
effective search space: 12970043076
effective search space used: 12970043076
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.