Guide to the Human Genome
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Search of human proteins with 134133246

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
         (460 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134133246 hypothetical protein LOC285753 [Homo sapiens]            917   0.0  
gi|28603844 hypothetical protein LOC285753 [Homo sapiens]             917   0.0  
gi|45430055 translokin [Homo sapiens]                                 242   6e-64
gi|34878904 synaptonemal complex protein 1 [Homo sapiens]              67   4e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     62   1e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    60   5e-09
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]         60   5e-09
gi|58530840 desmoplakin isoform I [Homo sapiens]                       59   7e-09
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       59   9e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    59   9e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    59   9e-09
gi|55770834 centromere protein F [Homo sapiens]                        59   9e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             59   1e-08
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              59   1e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    59   1e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    58   2e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    58   2e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    58   2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    58   2e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    58   2e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    57   4e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    57   4e-08
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    56   6e-08
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    56   6e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         56   6e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        55   1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        55   1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         55   1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         55   1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         55   1e-07

>gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
          Length = 460

 Score =  917 bits (2371), Expect = 0.0
 Identities = 460/460 (100%), Positives = 460/460 (100%)

Query: 1   MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
           MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK
Sbjct: 1   MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60

Query: 61  TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
           TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS
Sbjct: 61  TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120

Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
           SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK
Sbjct: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180

Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
           ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS
Sbjct: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240

Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
           KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS
Sbjct: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300

Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
           RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI
Sbjct: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360

Query: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
           ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK
Sbjct: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420

Query: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
           NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
Sbjct: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460


>gi|28603844 hypothetical protein LOC285753 [Homo sapiens]
          Length = 460

 Score =  917 bits (2371), Expect = 0.0
 Identities = 460/460 (100%), Positives = 460/460 (100%)

Query: 1   MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
           MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK
Sbjct: 1   MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60

Query: 61  TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
           TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS
Sbjct: 61  TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120

Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
           SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK
Sbjct: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180

Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
           ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS
Sbjct: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240

Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
           KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS
Sbjct: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300

Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
           RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI
Sbjct: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360

Query: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
           ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK
Sbjct: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420

Query: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
           NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
Sbjct: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460


>gi|45430055 translokin [Homo sapiens]
          Length = 500

 Score =  242 bits (617), Expect = 6e-64
 Identities = 146/403 (36%), Positives = 225/403 (55%), Gaps = 33/403 (8%)

Query: 51  NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK 110
           NS+A+  ALK LQ+KI RLELER QAE+++  LSRE  +YKK L+ +  ER  +  E  K
Sbjct: 65  NSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESK 124

Query: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
             ++++ QL +A+++C LLEKQLEY + M+ + E E+  +LE+Q  L+RE++ DQ  + +
Sbjct: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184

Query: 171 KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
           +LEKLD+LE+E  +LTT Q  AE K++ LE KL EEE +RK  Q KA+ELQTGLE +++I
Sbjct: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244

Query: 231 MSS-----VSNLKHSKEKKKSSKKTKCIKR----RPPWQICSKFGALPFVAEK------- 274
                   V N +  K+KK    + K  +     +P +++C   G +PFVA K       
Sbjct: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLC--LGDMPFVAGKSTSPSHA 302

Query: 275 -----------MRQHRDPHILQKPFN-VTETRCLPKPSRTTSWCKAIPPDSEKSISICDN 322
                      M+QH       +  N +   + +      +      PP S     I + 
Sbjct: 303 VVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSN---GINEE 359

Query: 323 LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK 382
           LSE+L  +QDE  QMS +HQ+L K ++E+ +  + D +ECELE L+ +ME K  QI+K++
Sbjct: 360 LSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVR 419

Query: 383 KHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
           K+Q  + K + + Q  ++        E+        I  +  K
Sbjct: 420 KYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNK 462


>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
          Length = 976

 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 81/364 (22%), Positives = 161/364 (44%), Gaps = 59/364 (16%)

Query: 53  QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENE----------TNERN 102
           Q LI  L+  ++++H LE++ T    +    S+E    K  LENE           N+ +
Sbjct: 465 QELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLS 524

Query: 103 LAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE 162
           L ++EL ++  D++++L + Q      +KQ E   + + N++  +  +  +   ++ E +
Sbjct: 525 LENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELK 584

Query: 163 QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKE----------EEHQRKL 212
           Q + ++  KL+K    E+ C  L   +K  E+K K++EE  +E          E  Q  +
Sbjct: 585 QKRDEVKCKLDK---SEENCNNL---RKQVENKNKYIEELQQENKALKKKGTAESKQLNV 638

Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
           ++ K ++L+  LE +K     +++    + + K   +   ++                  
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE----------------V 682

Query: 273 EKMRQHRDPHI-LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ 331
           EK +   D  + LQK     + RC  K +   +  +      +K I   D  SEL +   
Sbjct: 683 EKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEERD--SELGLYKS 737

Query: 332 DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKH-QDSVCK 390
            E +Q S      L+   E E      +++ EL  + K++EI+ E+  KLK+  +++   
Sbjct: 738 KEQEQSS------LRASLEIE----LSNLKAELLSVKKQLEIEREEKEKLKREAKENTAT 787

Query: 391 LQQK 394
           L++K
Sbjct: 788 LKEK 791



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 56/216 (25%), Positives = 103/216 (47%), Gaps = 18/216 (8%)

Query: 38  NLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN- 96
           N E+TS       +   L L  K L ++   + LE    ++++N   ++  +  K +EN 
Sbjct: 513 NTELTS-------HCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565

Query: 97  ---ETNERNLAH--QELIKQKKD-ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI 150
              ET  RN     +E +KQK+D +  +L  ++  C  L KQ+E   + +  +++E   +
Sbjct: 566 QETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKAL 625

Query: 151 LEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTT-QKTAEDKIKHLEEKLKEEEHQ 209
            ++     ++    ++K+     +L+  +++   +T T QK  EDK K  EE L EE  +
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDK-KISEENLLEEVEK 684

Query: 210 RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKK 245
            K+  D+A +LQ   EI K     ++ +    EK K
Sbjct: 685 AKVIADEAVKLQK--EIDKRCQHKIAEMVALMEKHK 718



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 94/418 (22%), Positives = 160/418 (38%), Gaps = 108/418 (25%)

Query: 51  NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENET---------NER 101
           NS+ L      L ++  +++  +   E  L     +  + +K +E +          NE+
Sbjct: 98  NSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEK 157

Query: 102 -NLAHQELIKQKKDISIQLSSAQSRCTLLE----------KQLEYTKR------MVLNVE 144
            +L  +E I++ KD+  + ++ +  C LL+          K+ EY +       M LN  
Sbjct: 158 VSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNN 217

Query: 145 REKNMILEQQAQLQREKEQDQM--KLYAKLEKLDVLEKECFR------------------ 184
            EK +   ++ ++Q E  + +M  KL    EK+  LE+E  +                  
Sbjct: 218 IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITE 277

Query: 185 -------LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKI-IMSSVSN 236
                  LT   + + DK+  LEEK K +    K   +K   L   LE  K+ +  SVS 
Sbjct: 278 KENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVST 337

Query: 237 LKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
            K  +E  + + KT          IC          E+  + R  H     F VTE    
Sbjct: 338 QKALEEDLQIATKT----------ICQLTEEKETQMEESNKARAAH----SFVVTEFE-- 381

Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL----DQMSMEHQELLKQMKETE 352
                 T+ C               +L ELL   Q  L    DQ+ +   EL K+  E E
Sbjct: 382 ------TTVC---------------SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE 420

Query: 353 SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMS-EASGIQQE 409
                     E+  L    E++ E++ K+   ++++  L +  Q  K++ E  G +QE
Sbjct: 421 ----------EMTKLTNNKEVELEELKKVLGEKETL--LYENKQFEKIAEELKGTEQE 466



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 69/363 (19%)

Query: 64  EKIHRLELERTQA-EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
           E++ R E +R +  ED L IL+ E  +    LE  T   N    EL + KK +       
Sbjct: 388 EELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLG------ 441

Query: 123 QSRCTLL--EKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
             + TLL   KQ E     +   E+E   +L+      REKE            +  LE 
Sbjct: 442 -EKETLLYENKQFEKIAEELKGTEQELIGLLQ-----AREKE------------VHDLEI 483

Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ-TGLEISKIIMSSVSNLKH 239
           +   +TT+++    ++K L+ +L+ E+ +        ++L     E+++        LK+
Sbjct: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543

Query: 240 SKE-----KKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
            +E     KK+  +  K I+     +   +   L +V E+++Q RD           E +
Sbjct: 544 QQEDINNNKKQEERMLKQIENLQETETQLR-NELEYVREELKQKRD-----------EVK 591

Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK----QMKE 350
           C                  +KS   C+NL + +      ++++  E++ L K    + K+
Sbjct: 592 C----------------KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQ 635

Query: 351 TESHSV-CDDIECELECLLKKM-EIKGEQISKLKKHQDSVCKLQQKVQNSKM--SEASGI 406
              + +  + +E ELE   +K  EI      +++  + S   L ++V+ +K+   EA  +
Sbjct: 636 LNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKL 695

Query: 407 QQE 409
           Q+E
Sbjct: 696 QKE 698


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 88/409 (21%), Positives = 164/409 (40%), Gaps = 35/409 (8%)

Query: 22   VPSFTQNEPSQNCHPANLEVTSPKILHSPNS-QALILALKTLQEKIHRLELERTQAEDNL 80
            V S  Q+E     H   LEV   K L      Q  ++ LK L E+  R   E T     L
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS---KL 1178

Query: 81   NILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMV 140
                 E    K + E           E  K  ++++IQL      C   E  LE     +
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC---CKKTEALLEAKTNEL 1235

Query: 141  LNVEREK-NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL 199
            +N+   K N IL + +  Q    + +  L  K   +  LE +  +LT  Q T     +  
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295

Query: 200  EEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPW 259
              +L+E+E+Q K  +     L T  E  +         +   +++ +S+K  CI +    
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQ--------KEGGNQQQAASEKESCITQLKK- 1346

Query: 260  QICSKFGALPFVAEKMRQHR-----------DPHI-LQKPFNVTETRCLPKPSRTT---S 304
            ++     A+  + E++++ +           D ++ LQ   +++E        R      
Sbjct: 1347 ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE 1406

Query: 305  WCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK--QMKETESHSVCDDIEC 362
             C+ +    + S  + D LS+  ++  +++D  S +  E  K  Q + T+  +   +++ 
Sbjct: 1407 KCELLDQVQDLSFKV-DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 363  ELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
            +LE   K+   K EQI+ LK+  D   K    ++     + S +++++S
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 69/385 (17%), Positives = 169/385 (43%), Gaps = 41/385 (10%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
            +K LQ ++     E  + ++ +N+L  E  Q  K  +    E      ++ K++ ++  +
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519

Query: 119  LSSAQSRCTLLEK-------QLEYTKRMVLNVEREKNM----ILEQQAQLQREKEQDQMK 167
            L S  +R   LE        ++E    ++ N  ++K++    ++++    Q   E+   +
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579

Query: 168  LYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEIS 227
            +    EK+  LE + + +    +T + +++H+   +K +E + K  +D+         + 
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR---------LE 1630

Query: 228  KIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE----KMRQHRDPHI 283
                + ++ LK   E+K ++ K + + +    +   K G    ++E       + R+ HI
Sbjct: 1631 SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690

Query: 284  LQKPF-----NVTETRCLPKPSR-TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQM 337
            L++       + +ET  +P+ ++   ++ +    DS+  +       E +  +Q  L   
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTYEEKISVLQRNL--- 1745

Query: 338  SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDS--VCKLQQKV 395
              E ++LL+++ + +  +V      E+ C  ++  IK E  ++ K+H+D   +  LQ+++
Sbjct: 1746 -TEKEKLLQRVGQEKEETVSSHF--EMRCQYQERLIKLEH-AEAKQHEDQSMIGHLQEEL 1801

Query: 396  QNSKMSEASGIQQEDSYPKGSKNIK 420
            +      +  + Q      G  NI+
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQ 1826



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 91/391 (23%), Positives = 165/391 (42%), Gaps = 52/391 (13%)

Query: 59  LKTLQEK-------IHRLELER----TQAEDNLNILSREAAQYK-KALENETN-ERNLAH 105
           LK  QEK       +  LEL++    T++E+ L  L +EA  Y+ + LE E++ E++L  
Sbjct: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL-- 580

Query: 106 QELIKQKKDISIQLSSAQSR-----CTLLEK---QLEYTKRMVLNVEREKNMILEQQAQL 157
           QE   Q KD+++ L + +++       ++EK   +LE  K     +  EK  +L+QQ Q 
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640

Query: 158 QREK-----EQDQMKLYAKLEKL------DVLEKECFRLTTTQKTAEDKIKHLEEKLKEE 206
           + EK     EQ++  L    E +      ++ EK   +L   Q   E     L E LK  
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR 700

Query: 207 ---EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICS 263
              E +  + +D+  +++  LE     M    N  H ++     K+ +   +R    +  
Sbjct: 701 HKLEEELSVLKDQTDKMKQELEAK---MDEQKN-HHQQQVDSIIKEHEVSIQRTEKALKD 756

Query: 264 KFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDN- 322
           +   L    E + + RD H+ +   +V       K S       +   D  +S     + 
Sbjct: 757 QINQL----ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812

Query: 323 ----LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI 378
                 E L  +Q +L  +  E   L KQ+ E E+     D+  EL+    +++   +Q+
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK--KDVCTELDAHKIQVQDLMQQL 870

Query: 379 SKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
            K     +   K   +V  SK+ + +  Q++
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 74/358 (20%), Positives = 162/358 (45%), Gaps = 48/358 (13%)

Query: 63  QEKIHRLELERTQAEDNLNI-LSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
           QE   +L+    + ++ + + L +  ++Y K  + +  + +LA +EL  QKK I   L+ 
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI---LTE 550

Query: 122 AQSRCTLLEKQLEYTKRMVLNVE--------REKNMILEQQAQLQREKEQDQMKLYAKLE 173
           ++++   L+++ E  +  +L +E          KN   +    L+ EK +   ++   +E
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610

Query: 174 K----LDVLEKECFRLTTTQ-KTAEDKIKHLEEKLKEEEHQRK--LFQDKASELQTGLEI 226
           K    L+ L+ +   L T + +  + + +   EKL+E+  Q K  L +DK    Q  +E 
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670

Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK 286
                    ++K ++ +  SS+ ++ +K R   +   +   L    +KM+Q         
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQE-------- 720

Query: 287 PFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK 346
                E +   + +       +I  + E SI   +       A++D+++Q+ +  +E  K
Sbjct: 721 ----LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK------ALKDQINQLELLLKERDK 770

Query: 347 QMKETESH--SVCDDI---ECELECLLKKMEI----KGEQISKLKKHQDSVCKLQQKV 395
            +KE ++H  ++  DI   E EL+    K+++    +     + K +++ + +LQQK+
Sbjct: 771 HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 100/442 (22%), Positives = 187/442 (42%), Gaps = 98/442 (22%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNIL-SREAAQYK--------------KALENETNERNL 103
            ++ L+  I R E E  QA   L++  S ++A ++              K L+ ET    L
Sbjct: 779  VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838

Query: 104  AHQ--ELIKQKKDISIQLSS----AQSRCTLLEKQ------------------------- 132
              Q  E+  QKKD+  +L +     Q     LEKQ                         
Sbjct: 839  TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898

Query: 133  LEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTA 192
             E TK+++  VE+E NMIL+ +   ++E E    KL AK + + +L +E     T  K  
Sbjct: 899  QEQTKQIL--VEKE-NMILQMREGQKKEIEILTQKLSAKEDSIHILNEE---YETKFKNQ 952

Query: 193  EDKIKHLEEKLKE-EEHQRKLFQDKASELQ-----TGLEISKI----------------- 229
            E K++ +++K KE +E  +K   D+ ++L+     T LE+S+                  
Sbjct: 953  EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012

Query: 230  -IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
             I  +VS L+ + +K++    T+  +R     I      L   AE++++  +  + +K  
Sbjct: 1013 GISDAVSRLE-TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071

Query: 289  NVTETR-------C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSME 340
             V E +       C   + ++  +W K      E+ +     L+EL    Q++L Q S  
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLK------EEGVKQDTTLNEL----QEQLKQKSAH 1121

Query: 341  HQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSK 399
               L +   + ++H   + +E +L   LK+     EQ+ +LK   ++   K+ +     K
Sbjct: 1122 VNSLAQDETKLKAH--LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179

Query: 400  MSEASGIQQEDSYPKGSKNIKN 421
             ++      + S+ K +K++++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLED 1201



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 69/358 (19%), Positives = 155/358 (43%), Gaps = 44/358 (12%)

Query: 60  KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA--HQELIKQ------ 111
           KT +E+   L+ E ++ +  +  + +++++ + A   + +E+ LA   QEL K+      
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505

Query: 112 --KKDISIQLSSAQSRCTLLEKQLEYTKRMVL-NVEREKNMILEQQAQLQREKEQDQMKL 168
             ++ + + L  +QS    + ++ E  + + L  +E +K  IL +     R+ +Q+    
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565

Query: 169 YAKLEKLD-VLEKECFRLTTTQKTAEDKIKHLE-EKLKEEEHQRKLFQDKASELQT-GLE 225
             ++ +L+  LEK    L   +  ++D   HLE EK K  +    + +   +EL++   +
Sbjct: 566 RTRILELESSLEKS---LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622

Query: 226 ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHIL- 284
              +    +  LK   + +    + KC +                  EK    +D  I+ 
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQ------------------EKETLLKDKEIIF 664

Query: 285 QKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQEL 344
           Q        + L K     +  +++  +  + +     L E L  ++D+ D+M    QEL
Sbjct: 665 QAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK---QEL 721

Query: 345 LKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSE 402
             +M E ++H      + +++ ++K+ E+  ++  K  K Q +  +L  K ++  + E
Sbjct: 722 EAKMDEQKNHH-----QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 83/433 (19%), Positives = 173/433 (39%), Gaps = 48/433 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKI--HRLELERTQAEDNLNILSRE 86
            E  +N H  N E+T     H    ++L    K  Q+ +   +L++ + Q +  +  L  +
Sbjct: 595  EAEKNKH--NKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 87   AAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
              Q K+ L  +      AH E + +K     +L   Q+    L  +L    +    +E E
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKT--LEKLDVKQTELESLSSELSEVLKARHKLEEE 706

Query: 147  KNMILEQQAQLQREKE--QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLK 204
             +++ +Q  ++++E E   D+ K + + +   ++++    +  T+K  +D+I  LE  LK
Sbjct: 707  LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766

Query: 205  EEEHQRKLFQDKASELQTGLEISK----------IIMSSVSNLKHSKEKKKSSKKTKCIK 254
            E +   K  Q     L+  ++ S+           +  S  +  H + K    +  +  +
Sbjct: 767  ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826

Query: 255  RRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSE 314
            +    +   +      VAE   Q +D         +     + +  +  S  +       
Sbjct: 827  KLLDLE-TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME----QKV 881

Query: 315  KSIS-ICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEI 373
            KS++ + ++  E     Q++  Q+ +E + ++ QM+E +          E+E L +K+  
Sbjct: 882  KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKK--------EIEILTQKLSA 933

Query: 374  KGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE------DSYPKGSKNIKNSPRKCL 427
            K + I  L +  ++  K Q+K       +A  +Q+       D   K  K ++N      
Sbjct: 934  KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN------ 987

Query: 428  TDTNLFQKNSSFH 440
            T   L QK   F+
Sbjct: 988  TALELSQKEKQFN 1000



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 101/423 (23%), Positives = 174/423 (41%), Gaps = 35/423 (8%)

Query: 26   TQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQ-EKIHRL-ELERTQAEDNLNIL 83
            T  E SQ     N ++      +S      +  L+T Q E+I  L E+ R +  D ++I 
Sbjct: 988  TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047

Query: 84   SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNV 143
             ++  Q  + L+ E +E  L  +E    +    I L   +     + K++ + K   +  
Sbjct: 1048 EKKLNQQAEELQ-EIHEIQLQEKEQEVAELKQKILLFGCEKE--EMNKEITWLKEEGVKQ 1104

Query: 144  EREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDV-LEKECFRLTTTQKTAEDKIKHL 199
            +   N + EQ  Q         QD+ KL A LEKL+V L K     T  Q+      + +
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE------QLV 1158

Query: 200  EEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPW 259
            E K+  EE +RK+  +  S+L+T  E  + + SS      S E K    K    +     
Sbjct: 1159 ELKMLAEEDKRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217

Query: 260  QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISI 319
             IC K       A   + +   +I     N   +R      RTT   +A+       I  
Sbjct: 1218 DICCKKTEALLEA---KTNELINISSSKTNAILSRISHCQHRTTKVKEAL------LIKT 1268

Query: 320  C--DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEI---K 374
            C    L   L  + +E + +++  Q+   Q++E E+      ++ ++E L+ + E    +
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ--IKSMKADIESLVTEKEALQKE 1326

Query: 375  GEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQ 434
            G    +    ++S C  Q K + S+   A  + +E+   K  K   +S  K LTD N+  
Sbjct: 1327 GGNQQQAASEKES-CITQLKKELSENINAVTLMKEEL--KEKKVEISSLSKQLTDLNVQL 1383

Query: 435  KNS 437
            +NS
Sbjct: 1384 QNS 1386



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 92/399 (23%), Positives = 166/399 (41%), Gaps = 95/399 (23%)

Query: 56  ILALKTLQEKIHRLELERTQAEDNLNILSREAA---QYKKALENETNERNLAHQELIK-- 110
           +  L+TLQ+++ R E    + ++ +     +       K+AL+ + +ER L   E IK  
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER-LQELEKIKDL 336

Query: 111 ---QKKDISIQLSSAQSRCTLLEKQLEYTKRMVL-NVEREKNMILE-------------- 152
              +K  +  QL  A++    L +QLE  K MV+   +R+ +  LE              
Sbjct: 337 HMAEKTKLITQLRDAKN----LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392

Query: 153 ----QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIK---HLEEKLK- 204
               Q  +L+ +KE+ +   + +LEK          L+T QKT E + K    ++E++K 
Sbjct: 393 QMTTQGEELREQKEKSERAAFEELEK---------ALSTAQKTEEARRKLKAEMDEQIKT 443

Query: 205 ----EEEHQRKLFQDKASELQTGLEI-SKIIMSSVSNLKHSKEKKKSSKKTKCIK----R 255
                EE +  L Q+ +   Q  +++  K     ++ L+   EK+ + K+ +  K    R
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503

Query: 256 RPPWQICSKFGA-------LPFVAEKMRQHR---DPHILQKPFNVTET----RCLPKPSR 301
              +Q   K          L    EK +Q     +   LQK   +TE+    R L + + 
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE 563

Query: 302 T---------TSWCKAIPPDSEKSISICDNLSE---------LLMAMQDELDQMSMEHQ- 342
           T         +S  K++  +  +S  +  +L            +M  + + +  S++HQ 
Sbjct: 564 TYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQ 623

Query: 343 --------ELLKQMKETESHSVCDDIECELECLLKKMEI 373
                   ++LKQ  +TE   + +  E E E LLK  EI
Sbjct: 624 DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 42/219 (19%), Positives = 89/219 (40%), Gaps = 58/219 (26%)

Query: 63   QEKIHRLELER-TQAEDNLNILSREAAQYK--KALENETNERNLAH-------------- 105
            Q+++HR+E+E  T   + L  L +   + K  + LE  T E++ +H              
Sbjct: 1866 QKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH 1925

Query: 106  ------------------QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE- 146
                              +E+++ +KD+ +     Q    +L+K+ +  +   +  E+E 
Sbjct: 1926 NDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED 1985

Query: 147  ---------KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIK 197
                     K ++ E   QL +++++ +M +   + K   +E E   L + Q+     +K
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL--LESHQEETNQLLK 2043

Query: 198  HLEEKLKEEEHQRKLFQD-----------KASELQTGLE 225
             + EK  + +   K +++           K  +LQT LE
Sbjct: 2044 KIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 34/155 (21%), Positives = 74/155 (47%), Gaps = 8/155 (5%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN--ERNLAHQELIKQKKDISI 117
            KTLQEK    ++   + ++  + L R+   ++  +E  T+  E+  A Q++  + K   +
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899

Query: 118  QLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
               + + +     K      +++ N+E + N +  + A  +REK++   ++    + L +
Sbjct: 1900 LEENTEEK----SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM 1955

Query: 178  LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKL 212
            L KE  +     K   D+ +  EEK+K+E+   +L
Sbjct: 1956 LRKEHQQELEILKKEYDQER--EEKIKQEQEDLEL 1988


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 62/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)

Query: 102  NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
            N+ H   +K    I   L SA++   +  ++++ E TK  +   E ++  + E+   L +
Sbjct: 827  NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ 886

Query: 160  EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
            EK   Q+++ A+ + L   E+ C +L  T+   E KIK + E+ ++EE        +++ 
Sbjct: 887  EKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946

Query: 213  FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
             +D+ SEL+  ++  ++ ++ V   KH+ E K  +             +  +   L    
Sbjct: 947  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 993

Query: 273  EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
             K+ +              E + L +  + T        D +      + L++  + ++ 
Sbjct: 994  AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1033

Query: 333  ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
            ++D +  S+E ++ ++   E     +  D++   E  +     K +   KLKK +  +  
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093

Query: 391  LQQKVQNSKMSEASGIQ 407
            LQ K+++    +A G+Q
Sbjct: 1094 LQSKIED---EQALGMQ 1107



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 84/392 (21%), Positives = 171/392 (43%), Gaps = 43/392 (10%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            E +++    N E+T+ K         L   +  L+  + ++E E+   E+ +  L+ E A
Sbjct: 928  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 987

Query: 89   QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
               + +   T E+  A QE  +Q  D    L + + +   L K     ++ V ++E    
Sbjct: 988  GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1041

Query: 149  MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
              LEQ+ +++ + E+ + KL   L+    L +E     +T     DK + L+EKLK++E 
Sbjct: 1042 --LEQEKKIRMDLERAKRKLEGDLK----LAQE-----STMDIENDK-QQLDEKLKKKEF 1089

Query: 209  QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
            +    Q K  + Q  G+++ K I    + ++  +E+ ++ +  + K  K+R         
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149

Query: 260  --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
              +   + G       +M + R+    +   ++ E     + +  T   K     +E   
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1209

Query: 318  SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
             I DNL  +   ++ E  +M ME  +L   M ET S +     +  LE + + +E   +Q
Sbjct: 1210 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNM-ETVSKA-----KGNLEKMCRALE---DQ 1259

Query: 378  ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
            +S++K  ++     QQ++ N   ++ + +Q E
Sbjct: 1260 LSEIKTKEEE----QQRLINDLTAQRARLQTE 1287



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            QA   +L   +E+  +L   + Q E  +  ++  A   ++     T ++     E  + K
Sbjct: 896  QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955

Query: 113  KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
            KDI  ++L+ A+     +EK+   T+  V N+  E   + E  A+L +EK+  Q      
Sbjct: 956  KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010

Query: 172  LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
            L+ L   E +   LT  +   E ++  LE  L++E+  R   +    +L+  L++++   
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQEST 1070

Query: 232  SSVSNLKHSKEKKKSSKK 249
              + N K   ++K   K+
Sbjct: 1071 MDIENDKQQLDEKLKKKE 1088



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 65/326 (19%), Positives = 139/326 (42%), Gaps = 32/326 (9%)

Query: 68   RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
            ++E +  + E  LN  +R AA+   AL N  N + +         KD  + L  A     
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQAIL--------KDTQLHLDDALRSQE 1669

Query: 128  LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
             L++QL   +R    ++ E   +     Q +R ++  + +L    E++ +L  +   L  
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729

Query: 188  TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKS 246
            T+K  E  I  ++ ++++   + +  ++KA +  T    +++ +        H +  KK+
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 247  SKKT-KCIKRR--PPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
             ++T K ++ R     Q+  K G   +  +  ++R+       ++  NV   + L K  R
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHER 1849

Query: 302  TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
                      +  K+I          + +QD +D++  + +   +Q +E E  S  +   
Sbjct: 1850 KVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSK 1899

Query: 359  --DIECELECLLKKMEIKGEQISKLK 382
               I+ ELE   ++ +I   Q++KL+
Sbjct: 1900 FRRIQHELEEAEERADIAESQVNKLR 1925



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 63/361 (17%), Positives = 147/361 (40%), Gaps = 34/361 (9%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKK---ALENETNERNLAHQELIKQKKDISIQ 118
            L+++   +++E      N+  +S+     +K   ALE++ +E     +E  +   D++ Q
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ 1280

Query: 119  LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVL 178
             +  Q+      +QL+    +V  + R K    +Q  +L+R+ E++     A    L   
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340

Query: 179  EKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLK 238
              +C                L E+ +EE+  +   Q   S+  +  E+++      ++  
Sbjct: 1341 RHDC--------------DLLREQYEEEQEAKAELQRAMSKANS--EVAQWRTKYETDAI 1384

Query: 239  HSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNV--TETRCL 296
               E+ + +KK    + +   +      A     EK +Q     +     +V  T   C 
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444

Query: 297  PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSME-------HQELLKQMK 349
                +  ++ K +    +K    C+     L A Q E   +S E       ++E L Q++
Sbjct: 1445 ALDKKQRNFDKILAEWKQK----CEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500

Query: 350  ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
              +  +   +++ E+  L +++   G++I +L+K +  V + + ++Q +     + ++ E
Sbjct: 1501 TLKREN--KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHE 1558

Query: 410  D 410
            +
Sbjct: 1559 E 1559



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 80/408 (19%), Positives = 164/408 (40%), Gaps = 49/408 (12%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
            ++ L+E+I      R +AE   + LSRE  +  + LE          E N++  A  E  
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1176

Query: 110  KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
            K ++D+    L    +  TL +K  +    +   + N++R K        +L++EK + +
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1229

Query: 166  MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
            M++      ++ + K    L    +  ED++  ++ K +E++        QR   Q ++ 
Sbjct: 1230 MEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESG 1289

Query: 219  ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
            E    L+    ++S +     S+ K+  +++ + +KR+   +I +K  AL    +  R  
Sbjct: 1290 EYSRQLDEKDTLVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-SALAHALQSSRHD 1343

Query: 279  ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE 333
                R+ +  ++       R + K  S    W      D   +I   + L E    +   
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD---AIQRTEELEEAKKKLAQR 1400

Query: 334  LDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKL-- 391
            L Q + EH E +   K          ++ E+E L+  +E      + L K Q +  K+  
Sbjct: 1401 L-QDAEEHVEAV-NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458

Query: 392  --QQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNS 437
              +QK + +     +  ++  S       IKN+  + L      ++ +
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 83/454 (18%), Positives = 180/454 (39%), Gaps = 65/454 (14%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
            ++L  ++ +++    ++ D L  L RE    ++ + + T    E      EL K KK + 
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ--QAQLQREKEQDQM-------- 166
             + S  Q+     E  LE+ +  +L ++ E N +  +  +   ++++E DQM        
Sbjct: 1539 QEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV 1598

Query: 167  ----------------------KLYAKLEKLDVLEKECFRLT--------TTQKTAEDKI 196
                                  K+   L ++++      R+          TQ   +D  
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ 1658

Query: 197  KHLEEKLKEEE---HQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKK--KSSKKTK 251
             HL++ L+ +E    Q  + + +A+ LQ  +E  +  +      +   E++   +S++ +
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718

Query: 252  CIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTE--TRCLPKPSRTTSWCKAI 309
             +  +    I +K      +++   +  D  I+Q+  N  E   + +   +      K  
Sbjct: 1719 LLHTQNTSLINTKKKLETDISQIQGEMED--IIQEARNAEEKAKKAITDAAMMAEELKKE 1776

Query: 310  PPDSEKSISICDNLSELLMAMQ---DELDQMSMEHQELLKQMKETESHSVCDDIECELEC 366
               S     +  NL + +  +Q   DE +Q++++  +  KQ+++ E+     ++E E+E 
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQKLEAR--VRELEGEVES 1832

Query: 367  LLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKC 426
              K+     E +  L+KH+  V +L  + +  + +        D      K+ K    + 
Sbjct: 1833 EQKR---NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1889

Query: 427  LTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
               +N+    S F  I+ H L+    R DI   Q
Sbjct: 1890 EEQSNV--NLSKFRRIQ-HELEEAEERADIAESQ 1920


>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
          Length = 1317

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 88/397 (22%), Positives = 173/397 (43%), Gaps = 53/397 (13%)

Query: 63  QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH----------------Q 106
           ++K  + ELER Q E        E  Q +   + E+ +R   H                +
Sbjct: 622 KQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEE 681

Query: 107 ELIKQKKDISIQLSSAQSRCTL-LEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
           E ++++++I +Q    +    L ++++L+  K +  N + EK  I ++  QLQ+EK++  
Sbjct: 682 ERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQ- 740

Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ----DKASELQ 221
              YAKLE    LEK+  RL   +K     + HLEE+L+E++   +L +        E +
Sbjct: 741 ---YAKLE----LEKK--RLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEK 791

Query: 222 TGLE-----ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGAL----PFVA 272
             LE     + ++  +     +  +E +K+  +    KRR   ++ +    L      + 
Sbjct: 792 RDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILK 851

Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
           +++++ ++     K  +  E+R L K   + +    +P D EK       +   L   + 
Sbjct: 852 KEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEK----IKPVEYRLQYKER 907

Query: 333 ELDQMSMEHQELLKQMKETESHSVCDDIECELECLL----KKMEIKGEQISKLKKHQDSV 388
           +L  +   H   L + K+  +  + D     L+  L    K+ME K EQ+++ + + + +
Sbjct: 908 QLQYLLQNHLPTLLEEKQ-RAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQL 966

Query: 389 CKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
            KLQ   + +    A+  +QE+   K  K I  S  K
Sbjct: 967 QKLQATFEFT----ANIARQEEKVRKKEKEILESREK 999



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 13/157 (8%)

Query: 61   TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            +L   ++++E E  + E+ L      A Q +K         N+A QE   +KK+  I  S
Sbjct: 937  SLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILES 996

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQR-----EKEQDQMKLYAKLE-K 174
              + +   LE+ L   +R    ++R   + +E + Q Q+        ++Q  L A LE +
Sbjct: 997  REKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAE 1056

Query: 175  LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
             + LEK+       Q+  E +I+ L++K+ E +  +K
Sbjct: 1057 QEALEKD-------QERLEYEIQQLKQKIYEVDGVQK 1086



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 35/153 (22%), Positives = 73/153 (47%), Gaps = 22/153 (14%)

Query: 85  REAAQYK-KALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNV 143
           +EAA+ + K      +  +L+  +L K ++++S  +        L    LE+ ++     
Sbjct: 555 KEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVM--------LYNPGLEFERQ----- 601

Query: 144 EREKNMILEQQAQLQREKEQDQMKLYAKLEKL----DVLEKECFRLTTTQKTAEDKIK-- 197
           +RE+   LE + +L  E E+ Q    A+LE++    +   KE   +    +  E+ +K  
Sbjct: 602 QREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRR 661

Query: 198 --HLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
             H+E KLK+   +++ F+++    Q  +E+ K
Sbjct: 662 SFHIENKLKDLLAEKEKFEEERLREQQEIELQK 694


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 85/412 (20%), Positives = 175/412 (42%), Gaps = 59/412 (14%)

Query: 26   TQNEPSQNCHPANLEVTSPKILHSPNS----QALILALKTLQEKIHRLELERTQAEDNLN 81
            T +E SQ      +E+     + +  S    Q+L  A KT+Q+K                
Sbjct: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDK---------------- 1479

Query: 82   ILSREAAQYKKALENETNERNLAHQE---LIKQKKDISIQLSSAQSRCTLLEKQLEYTKR 138
              ++E  + K+ ++ ETN+R     E   L + + D+    SSA      L+ Q +   R
Sbjct: 1480 --NKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR 1537

Query: 139  MVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV----LEKECFRLTTTQKTAED 194
            + ++ ER         +Q +  K+QD  +    L++L +    +E+E  RL  T      
Sbjct: 1538 LRIDYERV--------SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589

Query: 195  KIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMS-SVSNLKHSKEKKKSSKKTKCI 253
            K K LEE+L+      K    K + L   LE + I+   S  +L+  ++      + K  
Sbjct: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQR 1649

Query: 254  KRRPPWQICSKFGALPF-VAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPD 312
             +    ++ S+  AL   + ++    +  H+  + F     + +   SR+ +  K    +
Sbjct: 1650 TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ----KAIEDKSRSLNESKI---E 1702

Query: 313  SEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH------------SVCDDI 360
             E+  S+ +NL++  + +++EL  + +E+ +L +   E +S              + ++ 
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR 1762

Query: 361  ECELECLLKKMEIKGEQI-SKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
              EL+ L+  ++ + E +  +++K Q    +   ++Q SK      +Q+ +S
Sbjct: 1763 TLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERES 1814



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 88/428 (20%), Positives = 182/428 (42%), Gaps = 50/428 (11%)

Query: 64   EKIHRLELERTQAEDNLNILSREAAQ-YKKALENETNERNLAH--QELIKQKKDISIQLS 120
            E +  + ++RT  +    ++ +EAA  + + +E  T   +      E++K  +D+ ++  
Sbjct: 973  ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-- 1030

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVER-EKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLE 179
               ++  +LE++L   +    N E   KN  L+Q  Q + + E  Q K  AKL  L+ L+
Sbjct: 1031 --NTKIEVLEEELRLARDA--NSENCNKNKFLDQNLQ-KYQAECSQFK--AKLASLEELK 1083

Query: 180  KECFRLTTTQKTAEDK----IKHLEEKL-------KEEEHQRKLFQDKASELQTGL-EIS 227
            ++      + K   DK    IK L EK+       ++E+ +RK  +D+  + +    ++ 
Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143

Query: 228  KIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE----KMRQHRDPHI 283
            K       NL   K + + + K K  +      +  + G      E    K+R H +  +
Sbjct: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEM 1203

Query: 284  --LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEH 341
              L+  +  TE        +  S  K    DS+   +  D LS     ++DE+ +++   
Sbjct: 1204 SNLRNKYE-TEINITKTTIKEISMQK--EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260

Query: 342  QELLKQMKETESHSVCDDIECELECLLKK--MEIKGEQISKLK-----KHQDSVCKLQQK 394
             +  +Q +  E +++     C  E + KK  +EI+ +Q+ + +     +H+ S+ +  + 
Sbjct: 1261 LQATEQRRRAEENAL-QQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKT 1319

Query: 395  VQ--NSKMSEASGIQQEDSYPKG------SKNIKNSPRKCLTDTNLFQKNSSFHPIRVHN 446
            +Q  N ++       QE++  +       SK   N   + ++  N F+   +     +H 
Sbjct: 1320 IQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQ 1379

Query: 447  LQMKLRRD 454
            L M+   D
Sbjct: 1380 LTMQKEED 1387



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 39/204 (19%), Positives = 92/204 (45%), Gaps = 18/204 (8%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
            K +++K   L   + + E  L  L+    +    LE E     L + +L + + +     
Sbjct: 1687 KAIEDKSRSLNESKIEIE-RLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE----- 1740

Query: 120  SSAQSRCTLLE--KQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
            + +    T+LE   QL+ +    L ++   N +  ++  L++E E+ Q +      ++  
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE 1800

Query: 178  LEKECFRLTTTQKTAEDKIKHLE------EKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
             + +C ++   +++   KIK LE      ++L++E ++ K   +  + ++  LE  K  +
Sbjct: 1801 SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860

Query: 232  SSVSNLKHSKEKKKSSKKTKCIKR 255
             +  N    + K + S+K + I++
Sbjct: 1861 QNDLN----QWKTQYSRKEEAIRK 1880



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 42/176 (23%), Positives = 69/176 (39%), Gaps = 18/176 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQEL------IKQKKDI 115
            LQ  I+ L+ ER      +    ++A +    ++   N+     QE       IK  +  
Sbjct: 1766 LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1825

Query: 116  SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI---LEQQAQLQREKEQDQMKLYAKL 172
              +L   +      +  LE   R+   +E EK  I   L Q       KE+   K+ ++ 
Sbjct: 1826 KARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER 1885

Query: 173  EKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
            EK +  EK   R    +  AE  IK +EE+       R+  +D   E Q+ LE  +
Sbjct: 1886 EKSE-REKNSLRSEIERLQAE--IKRIEERC------RRKLEDSTRETQSQLETER 1932



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 17/150 (11%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            ++L++ +K L++   RL+    + ED LN       + K  LE ET  +    Q L  +K
Sbjct: 1813 ESLLVKIKVLEQDKARLQ----RLEDELN-------RAKSTLEAETRVK----QRLECEK 1857

Query: 113  KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
            + I   L+  +++ +  E+ +   +      EREKN +  +  +LQ E ++ + +   KL
Sbjct: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917

Query: 173  EKLDVLEKECFRLTTTQKTAEDKIKHLEEK 202
            E  D   +   +L T +   + +I  L ++
Sbjct: 1918 E--DSTRETQSQLETERSRYQREIDKLRQR 1945



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 42/194 (21%), Positives = 86/194 (44%), Gaps = 20/194 (10%)

Query: 68   RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
            RLE E+ Q +++LN    + ++ ++A+    +ER  + +E    K  +  ++   Q+   
Sbjct: 1852 RLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE----KNSLRSEIERLQAEIK 1907

Query: 128  LLEKQLEYTKRMVLNVEREKNMILE-QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT 186
             +E   E  +R + +  RE    LE ++++ QRE ++ + + Y    +    + EC    
Sbjct: 1908 RIE---ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE---TQTECEWTV 1961

Query: 187  TTQKTAEDKIKH-------LEEKLKEEEHQRKLFQDKASELQTGLEISKII--MSSVSNL 237
             T K   D ++         E +L ++    KL + K S  +   EI   +    S++  
Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021

Query: 238  KHSKEKKKSSKKTK 251
              S ++K S  + K
Sbjct: 2022 SASPKEKYSLVEAK 2035


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 97/428 (22%), Positives = 187/428 (43%), Gaps = 73/428 (17%)

Query: 53  QALILALKTLQEKIHRLELERTQAEDNLN---ILSREAAQYKKALENETNERNLAHQ--- 106
           Q L+  +++ Q+++++ E  + Q +D L     L  +  Q+   +  +T+   LA +   
Sbjct: 548 QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK 607

Query: 107 ---ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRM--VLNVEREKNMIL-EQQAQLQRE 160
              E  KQ K     L+S + R T  E++L+  + M  +L  E +K   L  +QA    E
Sbjct: 608 VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667

Query: 161 KEQDQMKLYAKLEKLDVLEK----------ECFRLTTTQ-KTAEDKIKHLEEKLKEE--- 206
            E+ Q  +Y K +K+ +LE+          E F++   Q K  + +++ L+  + E+   
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727

Query: 207 ---EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS-----KEKKKSSKKTKCIKRRPP 258
              E   K  Q+K  +L+T  E+ +  +  V+  +        E    +K+ + +K +  
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787

Query: 259 WQICSKFGALPFVAEKMRQHRDPHI----------LQKPFNVTETRCLPKPSRT------ 302
            Q+   F +L    +K+   +D  I          L K  N  +T  L   S+       
Sbjct: 788 DQV--SFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNL 845

Query: 303 -------TSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK-QMKETESH 354
                   +  KA+  + EK ++   N  + L  +Q+E + +    QE+ +  +KE  S 
Sbjct: 846 LKGKEEQMNTMKAVLEEKEKDLA---NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 902

Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQD----SVCKLQQKVQNSKMSEASGIQQ-- 408
           S  +    ELE +LK+ E + +++  + K ++    S  +L Q VQ+      S I+Q  
Sbjct: 903 SQFE----ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958

Query: 409 EDSYPKGS 416
           + +Y + S
Sbjct: 959 QQNYQQAS 966



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/196 (23%), Positives = 91/196 (46%), Gaps = 26/196 (13%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELI--- 109
            +AL    K LQ+K+++   ER Q  + + + ++E    KK     +   NL++ E +   
Sbjct: 1018 EALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVL--KKLFPKVSVPSNLSYGEWLHGF 1075

Query: 110  KQKKDISIQLSSAQSRCTLLEKQLEYTKRM----VLNVEREKNMILEQQA---QLQREKE 162
            ++K    +  +S      +LE +L+    M     L  E+ K+++ E +    +LQR  E
Sbjct: 1076 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1135

Query: 163  QDQMKLYAKLEK-----------LDVLEKECFRLTTTQKTAED---KIKHLEEKLKEEEH 208
            Q++ K   K+++               E+E  RL +  K  E+   + +HLE +L++ E 
Sbjct: 1136 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1195

Query: 209  QRKLFQDKASELQTGL 224
            +R  +  +  EL+  L
Sbjct: 1196 ERSTYVTEVRELKAQL 1211


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 63/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)

Query: 102  NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
            N+ H   +K    I   L SA++   +  ++++ +  K  +   E ++  + E+   L +
Sbjct: 829  NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLK 888

Query: 160  EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
            EK   Q+++ A+ E L   E+ C +L  T+   E KIK + E+ ++EE        +++ 
Sbjct: 889  EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948

Query: 213  FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
             +D+ SEL+  ++  ++ ++ V   KH+ E K  +             +  +   L    
Sbjct: 949  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 995

Query: 273  EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
             K+ +              E + L +  + T        D +      + L++  + ++ 
Sbjct: 996  AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1035

Query: 333  ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
            ++D +  S+E ++ L+   E     +  D++   E ++     K +   KLKK +  +  
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095

Query: 391  LQQKVQNSKMSEASGIQ 407
            LQ K+++    +A GIQ
Sbjct: 1096 LQSKIED---EQALGIQ 1109



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            E +++    N E+T+ K         L   +  L+  + ++E E+   E+ +  L+ E A
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 89   QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
               + +   T E+  A QE  +Q  D    L + + +   L K     ++ V ++E    
Sbjct: 990  GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1043

Query: 149  MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
              LEQ+ +L+ + E+ + KL   L+    L +E           E++ + L+EKLK++E 
Sbjct: 1044 --LEQEKKLRMDLERAKRKLEGDLK----LAQESIM------DIENEKQQLDEKLKKKEF 1091

Query: 209  QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
            +    Q K  + Q  G+++ K I    + ++  +E+ ++ +  + K  K+R         
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 260  --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
              +   + G       +M + R+    +   ++ E     + +  T   K     +E   
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211

Query: 318  SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
             I DNL  +   ++ E  +M ME  +L   + ET S +     +  LE + + +E   +Q
Sbjct: 1212 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNV-ETVSKA-----KGNLEKMCRTLE---DQ 1261

Query: 378  ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
            +S+LK  ++     QQ++ N   ++   +Q E
Sbjct: 1262 LSELKSKEEE----QQRLINDLTAQRGRLQTE 1289



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            QA    L   +E+  +L   + Q E  +  ++  A   ++     T ++     E  + K
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957

Query: 113  KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
            KDI  ++L+ A+     +EK+   T+  V N+  E   + E  A+L +EK+  Q      
Sbjct: 958  KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012

Query: 172  LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
            L+ L   E +   LT  +   E ++  LE  L++E+  R   +    +L+  L++++  +
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072

Query: 232  SSVSNLKHSKEKKKSSKK 249
              + N K   ++K   K+
Sbjct: 1073 MDIENEKQQLDEKLKKKE 1090



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 80/424 (18%), Positives = 171/424 (40%), Gaps = 78/424 (18%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
            ++ L+E+I      R +AE   + LSRE  +  + LE          E N++  A  E  
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1178

Query: 110  KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
            K ++D+    L    +  TL +K  +    +   + N++R K        +L++EK + +
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1231

Query: 166  MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
            M++      ++ + K    L    +T ED++  L+ K +E++        QR   Q ++ 
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 219  ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
            E    L+  + ++S +     S+ K+  +++ + +KR+   +I +K  AL    +  R  
Sbjct: 1292 EFSRQLDEKEALVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-NALAHALQSSRHD 1345

Query: 279  ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDS-------------------- 313
                R+ +  ++       R L K  +    W      D+                    
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405

Query: 314  -----EKSISICDNLSELLMAMQDELDQMSMEHQE-------LLKQMKE-----TESHSV 356
                 E   + C +L +    +Q+E++ + ++ +        L K+ +       E    
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465

Query: 357  CDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEASGIQQEDSYPKG 415
            C++   ELE   K+    G ++ K+K  +++S+ +L+   + +K  +       +   +G
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 1525

Query: 416  SKNI 419
             K I
Sbjct: 1526 GKRI 1529



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 63/326 (19%), Positives = 136/326 (41%), Gaps = 32/326 (9%)

Query: 68   RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
            ++E +  + E  LN  +R AA+   AL N  N + +         KD  I L  A     
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQGIL--------KDTQIHLDDALRSQE 1671

Query: 128  LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
             L++QL   +R    ++ E   +     Q +R ++  + +L    E++ +L  +   L  
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731

Query: 188  TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
            T+K  E  I  ++ ++++   + +  ++KA +  T      E  K    + ++L+  K+ 
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1791

Query: 244  KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
             + + K   ++     Q+  K G   +  +  ++R+       ++  N    + L K  R
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 302  TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
                      +  K+I          + +QD +D++  + +   +Q +E E  S  +   
Sbjct: 1852 RVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901

Query: 359  --DIECELECLLKKMEIKGEQISKLK 382
               ++ ELE   ++ +I   Q++KL+
Sbjct: 1902 FRKLQHELEEAEERADIAESQVNKLR 1927



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 62/360 (17%), Positives = 150/360 (41%), Gaps = 41/360 (11%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
            ++L  ++ +++    ++ D L  L RE    ++ + + T    E      EL K KK + 
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1540

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             +    Q+     E  LE+ +  +L ++ E N +          K +   K+  K E++D
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQV----------KSEVDRKIAEKDEEID 1590

Query: 177  VLEKECFRLT-TTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
             L++   R+  + Q T + +I+   + ++     +K  +   +E++  L  +        
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIR----LKKKMEGDLNEMEIQLNHAN------- 1639

Query: 236  NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ-HRDPHILQKPFNVTETR 294
              + + E  ++ + T+ I +     +     +   + E++    R  ++LQ    + E R
Sbjct: 1640 --RMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA--EIEELR 1695

Query: 295  C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLM----AMQDELDQMSMEHQELLKQMK 349
              L +  R+    +    D+ + + +    +  L+     ++ ++ QM  E +++L++ +
Sbjct: 1696 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEAR 1755

Query: 350  ETE---SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKVQNSKMSEASG 405
              E     ++ D      E  LKK +     + ++KK+ +   K LQ ++  ++     G
Sbjct: 1756 NAEEKAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1813


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 63/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)

Query: 102  NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
            N+ H   +K    I   L SA++   +  ++++ +  K  +   E ++  + E+   L +
Sbjct: 829  NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLK 888

Query: 160  EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
            EK   Q+++ A+ E L   E+ C +L  T+   E KIK + E+ ++EE        +++ 
Sbjct: 889  EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948

Query: 213  FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
             +D+ SEL+  ++  ++ ++ V   KH+ E K  +             +  +   L    
Sbjct: 949  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 995

Query: 273  EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
             K+ +              E + L +  + T        D +      + L++  + ++ 
Sbjct: 996  AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1035

Query: 333  ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
            ++D +  S+E ++ L+   E     +  D++   E ++     K +   KLKK +  +  
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095

Query: 391  LQQKVQNSKMSEASGIQ 407
            LQ K+++    +A GIQ
Sbjct: 1096 LQSKIED---EQALGIQ 1109



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            E +++    N E+T+ K         L   +  L+  + ++E E+   E+ +  L+ E A
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 89   QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
               + +   T E+  A QE  +Q  D    L + + +   L K     ++ V ++E    
Sbjct: 990  GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1043

Query: 149  MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
              LEQ+ +L+ + E+ + KL   L+    L +E           E++ + L+EKLK++E 
Sbjct: 1044 --LEQEKKLRMDLERAKRKLEGDLK----LAQESIM------DIENEKQQLDEKLKKKEF 1091

Query: 209  QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
            +    Q K  + Q  G+++ K I    + ++  +E+ ++ +  + K  K+R         
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 260  --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
              +   + G       +M + R+    +   ++ E     + +  T   K     +E   
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211

Query: 318  SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
             I DNL  +   ++ E  +M ME  +L   + ET S +     +  LE + + +E   +Q
Sbjct: 1212 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNV-ETVSKA-----KGNLEKMCRTLE---DQ 1261

Query: 378  ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
            +S+LK  ++     QQ++ N   ++   +Q E
Sbjct: 1262 LSELKSKEEE----QQRLINDLTAQRGRLQTE 1289



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            QA    L   +E+  +L   + Q E  +  ++  A   ++     T ++     E  + K
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957

Query: 113  KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
            KDI  ++L+ A+     +EK+   T+  V N+  E   + E  A+L +EK+  Q      
Sbjct: 958  KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012

Query: 172  LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
            L+ L   E +   LT  +   E ++  LE  L++E+  R   +    +L+  L++++  +
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072

Query: 232  SSVSNLKHSKEKKKSSKK 249
              + N K   ++K   K+
Sbjct: 1073 MDIENEKQQLDEKLKKKE 1090



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 80/424 (18%), Positives = 171/424 (40%), Gaps = 78/424 (18%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
            ++ L+E+I      R +AE   + LSRE  +  + LE          E N++  A  E  
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1178

Query: 110  KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
            K ++D+    L    +  TL +K  +    +   + N++R K        +L++EK + +
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1231

Query: 166  MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
            M++      ++ + K    L    +T ED++  L+ K +E++        QR   Q ++ 
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291

Query: 219  ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
            E    L+  + ++S +     S+ K+  +++ + +KR+   +I +K  AL    +  R  
Sbjct: 1292 EFSRQLDEKEALVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-NALAHALQSSRHD 1345

Query: 279  ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDS-------------------- 313
                R+ +  ++       R L K  +    W      D+                    
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405

Query: 314  -----EKSISICDNLSELLMAMQDELDQMSMEHQE-------LLKQMKE-----TESHSV 356
                 E   + C +L +    +Q+E++ + ++ +        L K+ +       E    
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465

Query: 357  CDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEASGIQQEDSYPKG 415
            C++   ELE   K+    G ++ K+K  +++S+ +L+   + +K  +       +   +G
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 1525

Query: 416  SKNI 419
             K I
Sbjct: 1526 GKRI 1529



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 63/326 (19%), Positives = 136/326 (41%), Gaps = 32/326 (9%)

Query: 68   RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
            ++E +  + E  LN  +R AA+   AL N  N + +         KD  I L  A     
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQGIL--------KDTQIHLDDALRSQE 1671

Query: 128  LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
             L++QL   +R    ++ E   +     Q +R ++  + +L    E++ +L  +   L  
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731

Query: 188  TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
            T+K  E  I  ++ ++++   + +  ++KA +  T      E  K    + ++L+  K+ 
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1791

Query: 244  KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
             + + K   ++     Q+  K G   +  +  ++R+       ++  N    + L K  R
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851

Query: 302  TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
                      +  K+I          + +QD +D++  + +   +Q +E E  S  +   
Sbjct: 1852 RVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901

Query: 359  --DIECELECLLKKMEIKGEQISKLK 382
               ++ ELE   ++ +I   Q++KL+
Sbjct: 1902 FRKLQHELEEAEERADIAESQVNKLR 1927



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 62/360 (17%), Positives = 150/360 (41%), Gaps = 41/360 (11%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
            ++L  ++ +++    ++ D L  L RE    ++ + + T    E      EL K KK + 
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1540

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             +    Q+     E  LE+ +  +L ++ E N +          K +   K+  K E++D
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQV----------KSEVDRKIAEKDEEID 1590

Query: 177  VLEKECFRLT-TTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
             L++   R+  + Q T + +I+   + ++     +K  +   +E++  L  +        
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIR----LKKKMEGDLNEMEIQLNHAN------- 1639

Query: 236  NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ-HRDPHILQKPFNVTETR 294
              + + E  ++ + T+ I +     +     +   + E++    R  ++LQ    + E R
Sbjct: 1640 --RMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA--EIEELR 1695

Query: 295  C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLM----AMQDELDQMSMEHQELLKQMK 349
              L +  R+    +    D+ + + +    +  L+     ++ ++ QM  E +++L++ +
Sbjct: 1696 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEAR 1755

Query: 350  ETE---SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKVQNSKMSEASG 405
              E     ++ D      E  LKK +     + ++KK+ +   K LQ ++  ++     G
Sbjct: 1756 NAEEKAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1813


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 75/368 (20%), Positives = 146/368 (39%), Gaps = 38/368 (10%)

Query: 48  HSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQE 107
           H    +  +   + LQ ++ + ++E  + E  LN    E  +     +  + +     Q+
Sbjct: 304 HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK 363

Query: 108 LIKQKKDISIQLSSAQS-RCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQM 166
           L K  +D+S Q  +A+S RC+L +K  E  K     + R++        +  + K +   
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423

Query: 167 KLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEI 226
           +L       +VL+ E  +LT+ ++  E+ ++  ++KL   E   +  Q K +EL+  +E 
Sbjct: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSME- 482

Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK 286
                          E KK +   K    +   ++C     L  + + + Q ++     K
Sbjct: 483 ---------------EMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527

Query: 287 PFNVTETRCL---------PKPSRTTSWCKAIPPDSEKSISICDNL----SELLMAMQDE 333
             N ++   L          + S T    K    D EK      +L       +  + D+
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587

Query: 334 LDQMSMEHQELLK--QMKETESHSVCDD---IEC---ELECLLKKMEIKGEQISKLKKHQ 385
           L +   E + LL   ++K+ E   + ++     C   E E LL +ME + E +     H 
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL 647

Query: 386 DSVCKLQQ 393
           ++  K QQ
Sbjct: 648 ETCLKTQQ 655



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 46/195 (23%), Positives = 86/195 (44%), Gaps = 28/195 (14%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQY---KKALENETNERNLAHQELIKQKKDI 115
            L+TL   +  L  ++T  ++ L  L +++      K  LEN+  + N   + L+K+ + +
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075

Query: 116  SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
              +LS +           +Y K   LNV +     L        EK +  ++L +  E++
Sbjct: 2076 QARLSES-----------DYEK---LNVSKALEAALV-------EKGEFALRLSSTQEEV 2114

Query: 176  DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEIS----KIIM 231
              L +   +L    +  E K  H+ EKLKE E +    +DK   L+  L++S    ++++
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVI 2174

Query: 232  SSVSNLKHSKEKKKS 246
                N K   E  K+
Sbjct: 2175 LDAENSKAEVETLKT 2189



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 85/409 (20%), Positives = 172/409 (42%), Gaps = 71/409 (17%)

Query: 61   TLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN-----ETNERNLAHQELI-----K 110
            +L++K+  LE E   +E+N  ++  +A   K  +E      E   R+L   EL       
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210

Query: 111  QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ--------QAQLQREKE 162
            +K++++ Q+   Q + + L+K L   K ++   E+ +  I E+        Q QL+   E
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270

Query: 163  Q------DQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEK-------LKEEEHQ 209
                   DQ  + A  + LD   +E  +L  + +    +++  E+K       LKE EH 
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH 2330

Query: 210  RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSK-KTKCIKRRPPWQICSKFG-A 267
              L + +   L+  LEI++      +N +H+  + ++SK + + +K +      S  G  
Sbjct: 2331 ADLLKGRVENLERELEIAR------TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384

Query: 268  LPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELL 327
            L  V  +  +    + LQK     + R        +S+   +    ++ + + +  S  +
Sbjct: 2385 LDVVTIRSEKENLTNELQK----EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440

Query: 328  MAMQDELDQM-----SMEHQELLKQMKETESHSVCDDIECELECLLKKM-EIKGEQI--- 378
              +Q +L ++     ++ + +   + KE    S  + +E E   LL+ + E K   I   
Sbjct: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ 2500

Query: 379  --------------SKLKKHQDSVCKLQQKVQN-----SKMSEASGIQQ 408
                           KL+K  + + +L+ ++Q+     SK+S+  G  Q
Sbjct: 2501 SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 85/382 (22%), Positives = 160/382 (41%), Gaps = 61/382 (15%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA---HQEL-IKQKKD 114
            L+   E+I RL+ +    E  ++ LS+   +++   E     RNL     Q++ + Q K+
Sbjct: 2517 LEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKN 2576

Query: 115  ISIQ--LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
             S+Q  L   QS    LE +LE TK   ++   + N +  ++ +LQRE  +   K     
Sbjct: 2577 ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ 2636

Query: 173  EKL----DVLEKECFRLTTTQKTAEDKIKHL---------------------EEKLKEE- 206
            E+L    + L  E   L    K+++D++K L                     E K++EE 
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEI 2696

Query: 207  -EHQRKLFQDKASELQTGLEISKIIMSSVSNLKH---SKEKKKSSKKTKC-IKRRPPWQI 261
             E+Q +L + +       L+ +K     +   +    SKE+  SS+K +  + +    ++
Sbjct: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 2756

Query: 262  CSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS-RTTSWCKAIPPDSEKSISIC 320
             +   A   + E++++        K  N+     L K + R     K +       I  C
Sbjct: 2757 NNSLKATTQILEELKK-------TKMDNLKYVNQLKKENERAQGKMKLL-------IKSC 2802

Query: 321  DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISK 380
              L E    +Q EL Q+    +   KQ   T   +  D++  E++ L + +E   E+  +
Sbjct: 2803 KQLEEEKEILQKELSQLQAAQE---KQKTGTVMDTKVDELTTEIKELKETLE---EKTKE 2856

Query: 381  LKKHQDSVCKL---QQKVQNSK 399
              ++ D  C L    +K++ +K
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAK 2878



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 71/353 (20%), Positives = 146/353 (41%), Gaps = 54/353 (15%)

Query: 99   NERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQ 158
            +ER+    E  +  K+ +I     Q+R   LE  LE  K+M  +++++   +++ + +++
Sbjct: 809  SERSECRLEADQSPKNSAI----LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864

Query: 159  RE-KEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKA 217
                + +QM      E    + K     +  Q    + +  LE K KE +      + + 
Sbjct: 865  ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924

Query: 218  SELQTGLEISKIIMSSVSNLKHSKE----KKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
            +E+Q   + + ++  S+  L+   E    +KK       + +R   ++  + G L  +  
Sbjct: 925  AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984

Query: 274  KMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSIS-ICDNLSELLMAMQD 332
             + Q +  +++QK               + S+   I  + EKSIS + D   +  + +  
Sbjct: 985  SLNQEK-MNLIQK---------------SESFANYID-EREKSISELSDQYKQEKLILLQ 1027

Query: 333  ELDQMSMEHQELLKQMK---ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVC 389
              ++    +++L ++ K   E  S   C   EC   C  +K E++  + +  K+HQ+ + 
Sbjct: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087

Query: 390  KL-----------------QQKV-------QNSKMSEASGIQQEDSYPKGSKN 418
            KL                 QQ +       QN+  SEA G++QE    K  +N
Sbjct: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN 1140



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 68/335 (20%), Positives = 155/335 (46%), Gaps = 42/335 (12%)

Query: 51   NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNER---NLAHQE 107
            +SQAL L    L+ +I +L  E+        +L +E+   +  L     E+   + A + 
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEK-------ELLVKESESLQARLSESDYEKLNVSKALEA 2095

Query: 108  LIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMK 167
             + +K + +++LSS Q     L + +E   R+ +  + +K + + ++ + +RE+E D +K
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLK-ERERENDSLK 2153

Query: 168  LYAKLEKLDVLEKECFRLTTTQ-------KTAEDKIKHLEEKLKEEEHQRKLFQDKASEL 220
                 +K++ LE+E       Q       + ++ +++ L+ +++E     K+F+     L
Sbjct: 2154 -----DKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTL 2208

Query: 221  QTGLE-ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHR 279
            ++  E ++K I      L    +   S K     K +   QI  +       A +M Q++
Sbjct: 2209 RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE----SKTAVEMLQNQ 2264

Query: 280  DPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ-DELDQMS 338
               + +    +   + + K +      +++ P  E+   + +++ +L   ++ DE  Q+ 
Sbjct: 2265 LKELNEAVAALCGDQEIMKATE-----QSLDPPIEEEHQLRNSIEKLRARLEADEKKQLC 2319

Query: 339  MEHQELLKQMKETESHSVCDDIECELECLLKKMEI 373
                 +L+Q+KE+E H+  D ++  +E L +++EI
Sbjct: 2320 -----VLQQLKESEHHA--DLLKGRVENLERELEI 2347



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 66/321 (20%), Positives = 120/321 (37%), Gaps = 49/321 (15%)

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
            N+ NE     + L  +K ++  +L+ ++S C    +++      +LN   E  ++ +   
Sbjct: 1298 NKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSG 1354

Query: 156  QLQREK----------EQDQMKLYAKLEKLDVLEKECFR-LTTTQKTAEDKIKHLEEKLK 204
             L  E           EQ   +    L  LD  E   +  LT + K  +     L+EK  
Sbjct: 1355 LLHGELVEDIPGGEFGEQPNEQHPVSLAPLD--ESNSYEHLTLSDKEVQMHFAELQEKFL 1412

Query: 205  EEEHQRKLFQD-------KASELQTGLEISK----IIMSSVSNLKHSKEKKKS------- 246
              + + K+  D       K SELQT ++  K    ++ +++ N +    K+         
Sbjct: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL 1472

Query: 247  --SKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK--------PFNVTETRCL 296
              S  + C+   P     S  G   F    + Q  D  +L            +V E  C 
Sbjct: 1473 VPSLSSSCV---PDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS 1529

Query: 297  PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSV 356
                   +  K  P    K +   ++L E+     ++L++  ME Q ++K  +  E   +
Sbjct: 1530 SLQEENLTR-KETPSAPAKGVEELESLCEVYRQSLEKLEE-KMESQGIMKNKEIQELEQL 1587

Query: 357  CDDIECELECLLKKMEIKGEQ 377
                  EL+CL K+   + EQ
Sbjct: 1588 LSSERQELDCLRKQYLSENEQ 1608



 Score = 35.8 bits (81), Expect = 0.084
 Identities = 92/410 (22%), Positives = 164/410 (40%), Gaps = 56/410 (13%)

Query: 49   SPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA---LENETNERNLAH 105
            S +   +   L  L+ K   L+L      D +     E  + KK+   LE+   E  L  
Sbjct: 893  SAHQNVVAETLSALENKEKELQL----LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS 948

Query: 106  QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQL-----QRE 160
            + L  +KK++S  +S  +     L ++    K +  ++ +EK  ++++         +RE
Sbjct: 949  ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE 1008

Query: 161  KEQDQMKLYAKLEKLDVLEKECFR-------LTTTQKTAEDKIKHLEEKLKE-----EEH 208
            K   ++    K EKL +L++ C         L+   K A++K   LE  L E     E  
Sbjct: 1009 KSISELSDQYKQEKLILLQR-CEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067

Query: 209  QRKLFQDK---ASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKF 265
            + +L Q K   A E Q  L           NL    E  + + +++        Q  SK 
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDN----QNNSKS 1123

Query: 266  GALPFVAEKMRQHRDPHILQKPFN--VTETRCLPKPSRTTSWCKAIPPDSEKSISICDNL 323
             A     E M    + + +QK  N  + E   L K  +T   C+ +     +S  I +++
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL-----ESEPIRNSV 1178

Query: 324  SELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK- 382
             E     + E +Q + + Q  L ++KE    S    +  +LE +L+  E+K ++  K K 
Sbjct: 1179 KE----RESERNQCNFKPQMDL-EVKEISLDSYNAQL-VQLEAMLRNKELKLQESEKEKE 1232

Query: 383  --KHQDSVCK---LQQKVQNSKMSEASG-----IQQEDSYPKGSKNIKNS 422
              +H+    +       +Q+ +  E SG     I  E+ Y  G   +  S
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTS 1282



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 57/277 (20%), Positives = 112/277 (40%), Gaps = 38/277 (13%)

Query: 107 ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQM 166
           +L K+K+    QL S ++     ++++E  K    N++RE   ++E    L++ K++   
Sbjct: 29  KLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISH 88

Query: 167 KLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE- 225
           +L  K  +++  E +         + + +I+ LE++LK  + + +  Q  A      L  
Sbjct: 89  ELQVKESQVNFQEGQL-------NSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141

Query: 226 ---ISKIIMSSV------SNLKHSKEKKKSSKKTKCIKR-RPPWQICSKFGALPFVAEKM 275
                KI  + +      S  K+   K+K +K+ +  KR     +      A   + +  
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQAT 201

Query: 276 RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSIS-------ICDNLSELLM 328
             HRD    Q   +V   +    PS  +S  +  P   + S S       +  + S L +
Sbjct: 202 MNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQI 261

Query: 329 AMQDE-------------LDQMSMEHQELLKQMKETE 352
             +D              LDQ+  ++QEL  ++ E E
Sbjct: 262 GKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 29/156 (18%), Positives = 67/156 (42%)

Query: 65   KIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQS 124
            ++H  +  R    DN+  ++    +    +ENE +        +  +   +   L   Q+
Sbjct: 1871 EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT 1930

Query: 125  RCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFR 184
                LEK  E  +++++ +E E +++  ++ QL+ E +    K  A  +  + ++++   
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990

Query: 185  LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASEL 220
            L + Q      I+  E ++KE+    +      SEL
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL 2026



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 62/341 (18%), Positives = 126/341 (36%), Gaps = 42/341 (12%)

Query: 144  EREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---- 199
            +R+   +L +  +L  +    +++L  K+E    LEK    L        +K+++     
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853

Query: 200  EEKLKEEEHQR------KLFQDKASELQTGLEISKIIMS------SVSNLKHSKEKKKSS 247
            +E L+  E         ++  DK+S    G  ++K+  S       V N       +K+S
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913

Query: 248  KKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCK 307
             + + +      ++           EK+   +D    QK     E       S       
Sbjct: 1914 IEHEALYLEADLEVVQ--------TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965

Query: 308  AIPPDSEKSISICDNLSELLMAMQDELDQMSME--HQELLKQMKETESHSVCDDIECELE 365
             +   S+K+ ++ D LSE +     EL+    E  H   + + +  E   +   +  ++ 
Sbjct: 1966 ELDTMSKKTTAL-DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024

Query: 366  CLLKKMEIKGEQISKLKKHQDSV----CKLQQKV------QNSKMSEASGIQ---QEDSY 412
             LLK      E++  L+K   ++    C+L+ ++      +   + E+  +Q    E  Y
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084

Query: 413  PKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRR 453
             K   N+  +    L +   F    S     VH L+  + +
Sbjct: 2085 EK--LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 76/395 (19%), Positives = 169/395 (42%), Gaps = 32/395 (8%)

Query: 59  LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK------ 112
           L  LQEK H L+ + TQ  + L   S    Q ++ L ++  E+  AH    + +      
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK-AHLRAAQDRVLSLET 621

Query: 113 --KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQ----------RE 160
              +++ QL+ ++ + + L+ Q++    ++L+ E  K     Q+A LQ          ++
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT---AQRADLQNHLDTAQNALQD 678

Query: 161 KEQDQMKLYAKLE----KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQ-RKLFQD 215
           K+Q+  K+  +L+    KL   ++ C +L +  K  ++K   LE+K +E E Q +KL  D
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738

Query: 216 ----KASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFV 271
               KAS+ Q   ++ +    +      + E  K  +  K I       +  K  AL  +
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798

Query: 272 AEKM-RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAM 330
            +K+ +Q  +  IL++ F         +     +  +    + +K     + L   L  +
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858

Query: 331 QDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
           +D+L ++S   +    + ++         ++ E  C   K +++ +  + LK+ ++    
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918

Query: 391 LQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
           L+++ + S   +      ++   +    +K + ++
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 76/388 (19%), Positives = 160/388 (41%), Gaps = 64/388 (16%)

Query: 63  QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
           ++++  L+L+ ++ E+ L    +E       L+++ ++    HQE    ++  + +L  A
Sbjct: 452 EQQVADLQLKLSRLEEQL----KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507

Query: 123 QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL---------- 172
           Q+    + +Q+    + + N+E       E  + L++E+E     LYAK+          
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED----LYAKIQAGEGETAVL 563

Query: 173 ----EKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
               EK   L+++  +LT   K   +  K  +E L ++  ++K     A +    LE S 
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623

Query: 229 IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
             ++S  N    + K+K S+    IK +    + ++       A K  Q  D   LQ   
Sbjct: 624 NELNSQLN----ESKEKVSQLDIQIKAKTELLLSAE-------AAKTAQRAD---LQNHL 669

Query: 289 NVTETRCLPKP---SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELL 345
           +  +     K    ++ T+    +    +     C  L   L   +++   +  + +EL 
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729

Query: 346 KQMKETESHS-------------------VCDDIECELECLLKKMEIKGEQISK----LK 382
            Q+K+ E+ S                   +  D+E     L K++E++ E +S     L+
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789

Query: 383 KHQDSVCKLQQKVQNSKMSEASGIQQED 410
           K  +++  ++QK+  +K  E   I ++D
Sbjct: 790 KKSEALESIKQKL--TKQEEEKQILKQD 815



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 48/363 (13%)

Query: 35   HPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKAL 94
            H   LE+ S +       + LI A  TL++     E E  Q + N+N L + + Q KK +
Sbjct: 927  HQLKLELNSMQ-------EQLIQAQNTLKQN----EKEEQQLQGNINELKQSSEQKKKQI 975

Query: 95   ENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQ 154
            E    E  +A  +  + +  +  QL+ A       E   E  K  VL    EK+   E  
Sbjct: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQ-----ELAAEKEKISVLQNNYEKSQ--ETF 1028

Query: 155  AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ 214
             QLQ +    + +L A  + L  +E++         +  ++I +  + ++E +  +   +
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088

Query: 215  DKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEK 274
              +++ +  L+     +  +   K  KEK+  ++K+K  +       C +   +  + E+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE--IKCRQEKEITKLNEE 1146

Query: 275  MRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL 334
            ++ H+   I ++  N+ + + L    +     KA   DS K+    +  ++ ++      
Sbjct: 1147 LKSHKLESI-KEITNLKDAKQLLIQQKLELQGKA---DSLKAAVEQEKRNQQILK----- 1197

Query: 335  DQMSMEHQELLKQM--KETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQ 392
            DQ+  E +EL K+   KE + HS                EIK +++  +KKH+++  KL 
Sbjct: 1198 DQVKKEEEELKKEFIEKEAKLHS----------------EIKEKEVG-MKKHEENEAKLT 1240

Query: 393  QKV 395
             ++
Sbjct: 1241 MQI 1243



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 68/351 (19%), Positives = 141/351 (40%), Gaps = 47/351 (13%)

Query: 59  LKTLQEKIHRLELERTQAEDNLNILSREAAQY-------KKALENETNERNLAHQELIKQ 111
           L++L++++   + E    +   ++  ++AAQ        K   + E + R  A Q++ + 
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196

Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
            ++++ + +  Q   T L ++       VL  E  +   L     L+RE+E +++K    
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK---- 252

Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL-EISKII 230
                    EC +L +   ++E  I  L  +L +   +  ++  +  +L++ + E+++  
Sbjct: 253 --------DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304

Query: 231 MSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNV 290
            +   NL      KK    TK  ++     +  K       A   ++  D   LQ   + 
Sbjct: 305 QTLTENL-----LKKEQDYTKLEEKHNEESVSKK----NIQATLHQKDLDCQQLQSRLSA 355

Query: 291 TETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKE 350
           +ET               I  +  +       L E L  ++ +   +  E ++L +Q +E
Sbjct: 356 SETS-----------LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404

Query: 351 TESHSVCDDIECELECLLKKM----EIKGEQISKLK-KHQDSVCKLQQKVQ 396
            E H +   ++ E+  L  K+       GE   +LK + Q S  KL  K Q
Sbjct: 405 KEQHGL--QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 63/369 (17%), Positives = 157/369 (42%), Gaps = 40/369 (10%)

Query: 53   QALILALKTLQEKIHRLE--LERTQAEDNLNILSREAA--QYKKALENETNERNLAHQEL 108
            +AL+  L T+++K+ ++   L+ +++E        +AA    +K  +   ++  +  +  
Sbjct: 849  EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908

Query: 109  IKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKL 168
            +K++K++   L   +     L+ +L   +  ++  +       +++ QLQ    + +   
Sbjct: 909  LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
              K ++++ L+ E  ++   QKT  +    L+++L +   +    ++K S LQ   E S+
Sbjct: 969  EQKKKQIEALQGE-LKIAVLQKTELE--NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025

Query: 229  IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
                 + +  + +E +  + +                  L  V EK+   ++  I  +  
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQD----------------LKSVEEKLSLAQEDLISNRNQ 1069

Query: 289  NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM 348
               + + + +     +    +  DS K       L E   A+QD   + S++ +EL   +
Sbjct: 1070 IGNQNKLIQELKTAKA---TLEQDSAKKE---QQLQERCKALQDIQKEKSLKEKEL---V 1120

Query: 349  KETESHSVCDDIECELECLLKKM--EIKG------EQISKLKKHQDSVCKLQQKVQNSKM 400
             E    +  ++I+C  E  + K+  E+K       ++I+ LK  +  + + + ++Q    
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180

Query: 401  SEASGIQQE 409
            S  + ++QE
Sbjct: 1181 SLKAAVEQE 1189



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 85/381 (22%), Positives = 155/381 (40%), Gaps = 77/381 (20%)

Query: 57  LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDIS 116
           LALK     + R E++  QA        +E   Y + L+ E  +     Q+  + K D  
Sbjct: 78  LALKRDDVTLLRQEVQDLQAS------LKEEKWYSEELKKELEKYQGLQQQ--EAKPDGL 129

Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
           +  SSA+ +   LE+QLE  +    N+++ K++  ++ AQL  E    + K Y +   L 
Sbjct: 130 VTDSSAELQS--LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK-YDEERSL- 185

Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASEL--QTGLEISKI----- 229
                       ++ AE K+  L E+L +E     + QD  +EL  + G+E   +     
Sbjct: 186 ------------REAAEQKVTRLTEELNKE---ATVIQDLKTELLQRPGIEDVAVLKKEL 230

Query: 230 --IMSSVSNLKHSKEKKKSSKKTKCIKRRPPW--------QICSKFGALP-----FVAEK 274
             + + + N+   +E++    K +C K +  +        Q+ S+    P     +V E 
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL 290

Query: 275 MRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL 334
            +     + L +  N T T  L K  +   + K     +E+S+S           +Q  L
Sbjct: 291 QKLKSSVNELTQK-NQTLTENLLK--KEQDYTKLEEKHNEESVS--------KKNIQATL 339

Query: 335 DQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK--------KHQD 386
            Q  ++ Q+L  ++  +E+          L  +  ++  KGE   KLK        K+Q 
Sbjct: 340 HQKDLDCQQLQSRLSASET---------SLHRIHVELSEKGEATQKLKEELSEVETKYQH 390

Query: 387 SVCKLQQKVQNSKMSEASGIQ 407
              + +Q  Q  +  E  G+Q
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQ 411



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 75/361 (20%), Positives = 143/361 (39%), Gaps = 69/361 (19%)

Query: 52  SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
           +Q L   L  ++ K   L+ E  Q +        E  Q+   L++E N+    H +L++ 
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQ----REEKEQHGLQLQSEINQ---LHSKLLET 426

Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
           ++    QL  A  R   L++Q + +   +++ E++   + + Q +L R +EQ + K+   
Sbjct: 427 ER----QLGEAHGR---LKEQRQLSSEKLMDKEQQ---VADLQLKLSRLEEQLKEKV--- 473

Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQD----KASELQTGLE-I 226
                              T   +++H  +K K++  +++  Q     K  E Q  LE +
Sbjct: 474 -------------------TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514

Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDP-HILQ 285
            + I      +++ +   + SK+   +  +    + +K  A       + Q ++  H LQ
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574

Query: 286 KPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSEL-------LMAMQDELDQMS 338
           +              + T   + +   SE      +NL +        L A QD +  + 
Sbjct: 575 E--------------QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620

Query: 339 MEHQELLKQMKET-ESHSVCD-DIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKV 395
               EL  Q+ E+ E  S  D  I+ + E LL     K  Q + L+ H D+    LQ K 
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680

Query: 396 Q 396
           Q
Sbjct: 681 Q 681


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 77/368 (20%), Positives = 160/368 (43%), Gaps = 38/368 (10%)

Query: 59  LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALE---NETNERNLAHQELIKQKKDI 115
           LK +Q      E ER  A+  ++ L+R A    K  E   +E  +     +E  K+++D+
Sbjct: 423 LKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDL 482

Query: 116 SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
            ++   +  +  L  K+LE   R +       + +  +  Q+ +EK++ + +LYA L+++
Sbjct: 483 KLKAQESIRQWKLKHKKLE---RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQI 539

Query: 176 DVLEKECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQD----------------KAS 218
           + L KE   + T +   E+++   EEKL++ + HQ  L  +                K S
Sbjct: 540 ENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS 599

Query: 219 ELQTGLEISKI-IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKM-R 276
           ++Q+ +++ K  +   ++ LK    K ++  K K ++ +   +  S   A   +A K+  
Sbjct: 600 KIQSQMKVEKAHLEEEIAELK----KSQAQDKAKLLEMQESIKDLSAIRA--DLANKLAE 653

Query: 277 QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQ 336
           + R    + K  +    +   +   T +    +  + +        L +L  ++Q    +
Sbjct: 654 EERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQR---ELKDLTSSLQSVKTK 710

Query: 337 MSMEHQELLKQMKETESHSVCDDIECELECLLKK--MEIKGEQISKLKKHQDSVCK--LQ 392
                QEL+K  K+ +S +       + E L +K   +I   Q+ KLK   D + +   Q
Sbjct: 711 HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770

Query: 393 QKVQNSKM 400
            + +N K+
Sbjct: 771 NENENKKL 778



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 75/362 (20%), Positives = 154/362 (42%), Gaps = 46/362 (12%)

Query: 45  KILHSPNSQALILALKTLQE---KIHRLELERTQAEDNLNILSREAAQYKKALENETNER 101
           K+ H    +AL    +T+ E   K +++  E+ + +  L    ++    +K L +   +R
Sbjct: 494 KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKR 553

Query: 102 NLAHQELIKQKK----------DISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMIL 151
            L  +EL  +++          D+ +++ ++      LE +L+   ++   ++ EK  + 
Sbjct: 554 ALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLE 613

Query: 152 EQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI--KHLEEKLKEEEHQ 209
           E+ A+L++ + QD+ KL    E +  L     R     K AE++   K + + L +   Q
Sbjct: 614 EEIAELKKSQAQDKAKLLEMQESIKDLS--AIRADLANKLAEEERAKKAVLKDLSDLTAQ 671

Query: 210 RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALP 269
            K   ++ + + T L++ + +        H +E K  +   + +K +    I        
Sbjct: 672 AKSRDEETATIITQLKLERDV--------HQRELKDLTSSLQSVKTKHEQNIQELMKHF- 722

Query: 270 FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMA 329
              +K +   + HI        E + + K  R            EK  S CD L+E L  
Sbjct: 723 ---KKEKSEAENHIRTLKAESLEEKNMAKIHRG---------QLEKLKSQCDRLTEELTQ 770

Query: 330 MQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIK---GEQISKLKKHQD 386
            ++E  ++ +++Q L  Q++E E H     I  E E L +  E +    +Q+  L+  Q+
Sbjct: 771 NENENKKLKLKYQCLKDQLEEREKH-----ISIEEEHLRRMEEARLQLKDQLLCLETEQE 825

Query: 387 SV 388
           S+
Sbjct: 826 SI 827



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 81/403 (20%), Positives = 157/403 (38%), Gaps = 67/403 (16%)

Query: 27  QNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSRE 86
           Q E  +N     LE++   +  S  S+      +TL  ++  L  + T+AE +   L  +
Sbjct: 276 QTETEKNQLEQELELSRRLLNQSEGSR------ETLLHQVEELRTQLTKAEGDRKGLQHQ 329

Query: 87  AAQYKKALENETNERN----------LAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
            +Q  K   N  +E+              Q+L KQ  D+ +QL+ +      +  +LE  
Sbjct: 330 VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA-----MASELEEV 384

Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
           KR +   ++EK  +  Q   L RE E  + +    L++L  ++         +K A+ +I
Sbjct: 385 KRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI 444

Query: 197 KHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRR 256
             L    ++   Q + +    SELQ               LK   EK++   K K  +  
Sbjct: 445 SELTRHAEDATKQAERY---LSELQQS-----------EALKEEAEKRREDLKLKAQESI 490

Query: 257 PPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKS 316
             W++  K         K+                  R L K S T      +   + + 
Sbjct: 491 RQWKLKHK---------KLE-----------------RALEKQSETVD---ELTGKNNQI 521

Query: 317 ISICDNLSELLMAMQDELDQMSMEHQELL--KQMKETESHSVCDDIECELECLLKKMEIK 374
           +   D L   L A   +++ +  E  ++L  + ++E E HS  + +  +++     +E++
Sbjct: 522 LKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR-DIKSHQADLELE 580

Query: 375 GEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
            +         +S  K Q K+Q+    E + +++E +  K S+
Sbjct: 581 VKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQ 623



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 86/418 (20%), Positives = 167/418 (39%), Gaps = 80/418 (19%)

Query: 69  LELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTL 128
           LELE   + D ++ L  E  +  K       E+    +E+ + KK      S AQ +  L
Sbjct: 577 LELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKK------SQAQDKAKL 630

Query: 129 LEKQLEYTKRMVLNV---------EREKNMILEQQAQL-----QREKEQDQMKLYAKLEK 174
           LE Q        +           ER K  +L+  + L      R++E   +    KLE+
Sbjct: 631 LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLER 690

Query: 175 LDVLEKECFRLTTTQKTAEDK--------IKHLE-EKLKEEEHQRKLFQDKASELQTGLE 225
            DV ++E   LT++ ++ + K        +KH + EK + E H R L   KA  L+    
Sbjct: 691 -DVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTL---KAESLEEK-N 745

Query: 226 ISKIIMSSVSNLK------------HSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
           ++KI    +  LK            +  E KK   K +C+K     Q+  +   +    E
Sbjct: 746 MAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKD----QLEEREKHISIEEE 801

Query: 274 KMRQHRDPHILQKPFNVTETRCLPKPSRTT---------SWCKAIPPDSEKSISICDNLS 324
            +R+  +  +  K     +  CL     +          + CK    DS + + +  +  
Sbjct: 802 HLRRMEEARLQLKD----QLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGP 857

Query: 325 ELLMAMQDELDQMSMEHQELLKQMKETESH----------------SVCDDIECELECLL 368
           ++       L +   + Q L +++KE E+                 ++ ++ E EL+CL 
Sbjct: 858 DIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLF 917

Query: 369 KKMEIKGEQISKL-KKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
           +++E + + + ++ ++ +D + + Q+K +     +   I  E S      ++++ P K
Sbjct: 918 QQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEK 975



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 15/157 (9%)

Query: 95   ENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQ 154
            E E  E+NL HQ L+  ++ +     + +S    L +Q+E  ++++  + REK  +LE+ 
Sbjct: 883  ERENREKNLRHQ-LMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941

Query: 155  AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ 214
             +              K E++  L+     L T+ + A D ++ + EKL   E  +    
Sbjct: 942  QR--------------KDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRD 987

Query: 215  DKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
              +S  +T    SK  +   S   H  + K  +K  K
Sbjct: 988  SCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFK 1024


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
           sapiens]
          Length = 1939

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 38/152 (25%), Positives = 78/152 (51%), Gaps = 9/152 (5%)

Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
           N+ H   +K    I   L SA++   +  ++++ E TK  +   E ++  + E+   L +
Sbjct: 827 NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ 886

Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
           EK   Q+++ A+ + L   E+ C +L  T+   E KIK + E+ ++EE        +++ 
Sbjct: 887 EKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946

Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKK 244
            +D+ SEL+  ++  ++ ++ V   KH+ E K
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENK 978



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 62/326 (19%), Positives = 138/326 (42%), Gaps = 32/326 (9%)

Query: 68   RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
            ++E +  + E  LN  +R+AA+   AL N  N + +         KD  + L  A     
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAE---ALRNLRNTQGIL--------KDTQLHLDDAIRGQD 1669

Query: 128  LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
             L++QL   +R    ++ E   +     + +R ++  + +L    E++ +L  +   L  
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLIN 1729

Query: 188  TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
            T+K  E  I  ++ ++++   + +  ++KA +  T      E  K    + ++L+  K+ 
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 244  KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
             + + K   ++     Q+  K G   +  +  ++R+       ++  NV   + L K  R
Sbjct: 1790 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849

Query: 302  TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
                      +  K+I          + +QD +D++  + +   +Q +E E  S  +   
Sbjct: 1850 RVKELTYQTEEDRKNI----------LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899

Query: 359  --DIECELECLLKKMEIKGEQISKLK 382
               ++ ELE   ++ +I   Q++KL+
Sbjct: 1900 FRKLQHELEEAKERADIAESQVNKLR 1925



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 6/198 (3%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            QA   AL   +E+  +L   + Q E  +  ++  A   ++     T ++     E  + K
Sbjct: 896  QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955

Query: 113  KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
            KDI  ++L+ A+     +EK+   T+  V N+  E   + E  A+L +EK+  Q      
Sbjct: 956  KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010

Query: 172  LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
            L+ L + E +   LT  +   E ++  LE  L++E+      +    +L+  L++++   
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070

Query: 232  SSVSNLKHSKEKKKSSKK 249
                N K    +K   K+
Sbjct: 1071 MDTENDKQQLNEKLKKKE 1088



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 41/203 (20%), Positives = 91/203 (44%), Gaps = 26/203 (12%)

Query: 63   QEKIHRLELERTQAEDNLNILSREAAQYKKALENE----TNERNLAHQELIKQKKDISIQ 118
            +E+  + EL+R  ++ N      E AQ++   E +    T E   A ++L ++ +D    
Sbjct: 1353 EEQEAKAELQRGMSKAN-----SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH 1407

Query: 119  LSSAQSRCTLLEKQLEYTKR----MVLNVEREKNMIL----------EQQAQLQREKEQD 164
            + +  S+C  LEK  +  +     ++++VER     +          +  A+ +++ E+ 
Sbjct: 1408 VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467

Query: 165  QMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL 224
            Q +L A  ++   L  E F++   +   E+ + HLE   +E ++ ++   D   ++  G 
Sbjct: 1468 QAELEASQKESRSLSTELFKV---KNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG 1524

Query: 225  EISKIIMSSVSNLKHSKEKKKSS 247
            +    +      L H K + ++S
Sbjct: 1525 KHIHELEKVKKQLDHEKSELQTS 1547



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 27/195 (13%)

Query: 51   NSQALILAL----KTLQEKIHRLELE-------RTQAEDNLNILSREAAQYKKALEN--- 96
            + QAL + L    K LQ +I  LE E       R +AE   + LSRE  +  + LE    
Sbjct: 1100 DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159

Query: 97   ------ETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI 150
                  E N++  A  E  K ++D+       ++    L K+   +   V  +  + + +
Sbjct: 1160 ATSAQIEMNKKREA--EFQKMRRDLEESTLQHEATAAALRKKHADS---VAELGEQIDSL 1214

Query: 151  LEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQR 210
               + +L++EK + +M++      ++ + K         +T ED++   E K KEEE QR
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS--EIKTKEEEQQR 1272

Query: 211  KLFQDKASELQTGLE 225
             + +  A + +   E
Sbjct: 1273 LINELSAQKARLHTE 1287



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 33/149 (22%), Positives = 68/149 (45%), Gaps = 14/149 (9%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
            ++L  ++ +++    ++ D+L  L RE    ++ + + T    E      EL K KK + 
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             + S  Q+     E  LE+ +  +L ++ E N +          K +   K+  K E+LD
Sbjct: 1539 HEKSELQTSLEEAEASLEHEEGKILRIQLELNQV----------KSEIDRKIAEKDEELD 1588

Query: 177  VLEKECFRLT-TTQKTAEDKIKHLEEKLK 204
             L++   R+  + Q T + +I+   + L+
Sbjct: 1589 QLKRNHLRVVESMQSTLDAEIRSRNDALR 1617


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 84/424 (19%), Positives = 185/424 (43%), Gaps = 77/424 (18%)

Query: 59   LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
            + +L+E++  L+ + T  +  L  L    A+ ++ +E    +R+   +E  ++  +    
Sbjct: 594  MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653

Query: 119  LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI----LEQQAQLQ------REKEQDQMKL 168
            L   + + +LL+  L   +  +L+++   + +    L++ ++L+       +K+++ +K+
Sbjct: 654  LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 713

Query: 169  YAKLEK-----------------LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
             ++L+K                 +  LE+E  R       A+ ++  L E LKE E+++ 
Sbjct: 714  ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 773

Query: 212  LFQDKASELQTGLEISKIIMSSVSNLKHSK--EKKKSSKKTKCIKRRPPWQICSKFGALP 269
                K +EL+  ++        V+NLKH +  EKKKS++  +  +RR             
Sbjct: 774  DKDKKIAELERQVKDQN---KKVANLKHKEQVEKKKSAQMLEEARRRE-----------D 819

Query: 270  FVAEKMRQHRDPHILQKPFNVTE-TRCLPKPSRTTSWCKAIPPDSEKSISICD-NLSELL 327
             + +  +Q +D  + +K   + E    L +  + T+  + +    E + +  +  + ELL
Sbjct: 820  NLNDSSQQLQD-SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 878

Query: 328  MAMQ---DELDQMSMEHQELLKQMKETESH----------SVCDDIECELECLLKKMEIK 374
            MAM+    EL+ M  +     + + E E+H           + + +E + E LL  +  K
Sbjct: 879  MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 938

Query: 375  G----------------EQISKLKKHQDS-VCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
                             E+++ LK+ +D  V +L+Q+ QN +M   +   ++D +     
Sbjct: 939  DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN-RMKLMADNYEDDHFKSSHS 997

Query: 418  NIKN 421
            N  N
Sbjct: 998  NQTN 1001



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 71/350 (20%), Positives = 148/350 (42%), Gaps = 79/350 (22%)

Query: 77  EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
           +D L++  R+    +K +EN   +  L  +E  KQ   +  ++ S Q+  T  +  L   
Sbjct: 563 KDMLDVKERKVNVLQKKIENL--QEQLRDKE--KQMSSLKERVKSLQADTTNTDTALTTL 618

Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
           +  +   ER    + EQ+ + +REK+          E++D  +K+        K  ++K+
Sbjct: 619 EEALAEKERTIERLKEQRDRDEREKQ----------EEIDNYKKDL-------KDLKEKV 661

Query: 197 KHLEEKLKEEEHQRKLFQDKASEL-QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKR 255
             L+  L E+E      ++ AS L  +GL+      S +  L+ + E+KK     +C+K 
Sbjct: 662 SLLQGDLSEKEASLLDLKEHASSLASSGLKKD----SRLKTLEIALEQKKE----ECLKM 713

Query: 256 RPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
                                                   L K        +A P  S++
Sbjct: 714 ESQ-------------------------------------LKKAHEAALEARASPEMSDR 736

Query: 316 SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
                 +L   +   +DE  +   E   LL+ +KE E+    +D + ++  L ++++ + 
Sbjct: 737 ----IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK--NDKDKKIAELERQVKDQN 790

Query: 376 EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
           ++++ L KH++ V    +K ++++M E +  ++ED+    S+ +++S RK
Sbjct: 791 KKVANL-KHKEQV----EKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRK 834


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 84/424 (19%), Positives = 185/424 (43%), Gaps = 77/424 (18%)

Query: 59  LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
           + +L+E++  L+ + T  +  L  L    A+ ++ +E    +R+   +E  ++  +    
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 625

Query: 119 LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI----LEQQAQLQ------REKEQDQMKL 168
           L   + + +LL+  L   +  +L+++   + +    L++ ++L+       +K+++ +K+
Sbjct: 626 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 685

Query: 169 YAKLEK-----------------LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
            ++L+K                 +  LE+E  R       A+ ++  L E LKE E+++ 
Sbjct: 686 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 745

Query: 212 LFQDKASELQTGLEISKIIMSSVSNLKHSK--EKKKSSKKTKCIKRRPPWQICSKFGALP 269
               K +EL+  ++        V+NLKH +  EKKKS++  +  +RR             
Sbjct: 746 DKDKKIAELERQVKDQN---KKVANLKHKEQVEKKKSAQMLEEARRRE-----------D 791

Query: 270 FVAEKMRQHRDPHILQKPFNVTE-TRCLPKPSRTTSWCKAIPPDSEKSISICD-NLSELL 327
            + +  +Q +D  + +K   + E    L +  + T+  + +    E + +  +  + ELL
Sbjct: 792 NLNDSSQQLQD-SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 850

Query: 328 MAMQ---DELDQMSMEHQELLKQMKETESH----------SVCDDIECELECLLKKMEIK 374
           MAM+    EL+ M  +     + + E E+H           + + +E + E LL  +  K
Sbjct: 851 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 910

Query: 375 G----------------EQISKLKKHQDS-VCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
                            E+++ LK+ +D  V +L+Q+ QN +M   +   ++D +     
Sbjct: 911 DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN-RMKLMADNYEDDHFKSSHS 969

Query: 418 NIKN 421
           N  N
Sbjct: 970 NQTN 973



 Score = 37.4 bits (85), Expect = 0.029
 Identities = 71/350 (20%), Positives = 148/350 (42%), Gaps = 79/350 (22%)

Query: 77  EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
           +D L++  R+    +K +EN   +  L  +E  KQ   +  ++ S Q+  T  +  L   
Sbjct: 535 KDMLDVKERKVNVLQKKIENL--QEQLRDKE--KQMSSLKERVKSLQADTTNTDTALTTL 590

Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
           +  +   ER    + EQ+ + +REK+          E++D  +K+        K  ++K+
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQ----------EEIDNYKKDL-------KDLKEKV 633

Query: 197 KHLEEKLKEEEHQRKLFQDKASEL-QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKR 255
             L+  L E+E      ++ AS L  +GL+      S +  L+ + E+KK     +C+K 
Sbjct: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKD----SRLKTLEIALEQKKE----ECLKM 685

Query: 256 RPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
                                                   L K        +A P  S++
Sbjct: 686 ESQ-------------------------------------LKKAHEAALEARASPEMSDR 708

Query: 316 SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
                 +L   +   +DE  +   E   LL+ +KE E+    +D + ++  L ++++ + 
Sbjct: 709 ----IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK--NDKDKKIAELERQVKDQN 762

Query: 376 EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
           ++++ L KH++ V    +K ++++M E +  ++ED+    S+ +++S RK
Sbjct: 763 KKVANL-KHKEQV----EKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRK 806


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 80/410 (19%), Positives = 178/410 (43%), Gaps = 49/410 (11%)

Query: 35  HPANLEVTSPKILH-SPNSQALILALKTLQ----------EKIHRLELERTQAEDNLNIL 83
           H  N E+TS ++L     +Q+L   ++ L+           KI ++E E  +    + IL
Sbjct: 452 HEVN-ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510

Query: 84  SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEY-------- 135
             E  Q K++L+N  N      +E  + +K I     +++ +  +LE++ E+        
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570

Query: 136 -------TKRMVLNVEREKNMILE-------QQAQLQREKEQDQMKL---YAKLEKLDVL 178
                   +  V ++E+E  ++ E       + ++++ EK Q + +L     K E+ + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630

Query: 179 EKECFRLTTTQKTAEDKIKHLE---EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
           E E   L    +  + KI +L+   EK++  E +    + +  +L+  L+  K +   + 
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690

Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRC 295
           +L+  KE  +  ++   ++R      C+         E      +   L+K   + +   
Sbjct: 691 SLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA-S 747

Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHS 355
             K  R     + +  ++++     +N ++ +  ++ EL  + ME+Q L K ++E +  S
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807

Query: 356 VCDDIECELECLLKKMEIKGEQISKLKKH---QDSVCKLQQKVQNSKMSE 402
              +   +LE   K +E +  Q+ K KK    ++   + Q +++++ + E
Sbjct: 808 KRLE---QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 86/410 (20%), Positives = 164/410 (40%), Gaps = 72/410 (17%)

Query: 62  LQEKIHRLELERTQ--------AEDNLNI-------------LSREAAQY---------- 90
           L+ K+H +E+ER           E+N+ +             L  E  Q           
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446

Query: 91  KKALENETNE--------RNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLN 142
           +K+L +E NE          + +Q L K  +++   + S +   + + K  +  +R+   
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506

Query: 143 VEREKNMILEQQAQLQ--REKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLE 200
           VE  +N I++++  LQ  +   +D MK  A+LEK          + T ++ +E +IK LE
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---------TIETLRENSERQIKILE 557

Query: 201 EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKC-IKRRPPW 259
           +   E EH  +         Q   E     +   + + H   K+ SSK +K   ++R   
Sbjct: 558 Q---ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614

Query: 260 QICSKFGALPFVAEKMRQ-----HRDPHILQKPFNVTETRC--LPKPSRTTSWCKAIPPD 312
           +    +      AE++        ++  +LQK     +  C  +    +  S  +     
Sbjct: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674

Query: 313 SEKSISICDNLSELLMAMQDELDQMSMEHQELLK--------QMKETESHSVCDDIECEL 364
            +K++    NL+  L +++ E  Q+  E+ EL +         MK  +      ++E E 
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734

Query: 365 ECLLKKMEIKGEQISKLKKHQDSVCKL---QQKVQNSKMSEASGIQQEDS 411
           E L K +E+      K ++ + S   L    Q++Q +  +    IQQ +S
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 67/368 (18%), Positives = 160/368 (43%), Gaps = 40/368 (10%)

Query: 71  LERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLE 130
           +E ++  D L+ L   ++  +    +   +R  + Q L       S++L+ A+++   L 
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL-------SVELADAKAKIRRLR 264

Query: 131 KQLEYTKRMVLNVEREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDVLEKECFRLTT 187
           ++LE     +L+ ++E   +  +  +LQ+E      D        ++LD L ++  R+  
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-- 322

Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSS 247
                 DK++    + KE  H  + ++ +  EL+   E +++++ + + L+   E  ++ 
Sbjct: 323 ------DKLESEVSRYKERLHDIEFYKARVEELK---EDNQVLLETKTMLEDQLEGTRAR 373

Query: 248 KKTKCIKRRPPWQICSKFGALPF--------VAEKMRQHRDPHILQKPFNVTETRCLPKP 299
                   +   Q+ +K   +          + E M ++    + QK  ++ E+  L   
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ-SMDESLHLGWE 432

Query: 300 SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDD 359
               S    +    +KS+       E+       L ++ ME+Q L K ++E    +  D 
Sbjct: 433 LEQISRTSELSEAPQKSLG-----HEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDS 485

Query: 360 IECELECLLKKMEIKGEQIS-KLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKN 418
           +E     +L KME + +++S K++  ++ + + +Q +QN +      ++++    K  + 
Sbjct: 486 VEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 419 IK-NSPRK 425
           ++ NS R+
Sbjct: 545 LRENSERQ 552



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 68/319 (21%), Positives = 140/319 (43%), Gaps = 39/319 (12%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI--QL 119
            L+ K   +E+ER    +N  + + + A   +  + ET   NL  Q L  Q++ +S+  Q 
Sbjct: 1042 LKVKDRLIEVER----NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097

Query: 120  SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE------QDQMKLYAKL- 172
            ++ Q++   L+ +         ++  +   +L QQ+ L+ E E      +D   LY  L 
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157

Query: 173  ---EKLDVLEK----ECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQDKAS----EL 220
               EKL++L +    E   L +   T +   K+LE + ++ E+   +L + K      E 
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217

Query: 221  QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRD 280
               +E  K+++ + ++   + E KK   +   +      Q+  +   L         H++
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKETEVL------QTDHKN 1270

Query: 281  PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE----LDQ 336
               L     + +TR   + S+     + +   S K  + C+ LS+L   +++E    LDQ
Sbjct: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1330

Query: 337  ---MSMEHQELLKQMKETE 352
               + ++++ LL+Q  E++
Sbjct: 1331 IQTLMLQNRTLLEQNMESK 1349



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 18/205 (8%)

Query: 46   ILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH 105
            +L + N + +    K L  +  RL    +Q      +L  +    K  L N   E+    
Sbjct: 1227 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286

Query: 106  QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
             E  K K+    Q        T L  Q E   ++  N+E E   +L+   Q+Q    Q++
Sbjct: 1287 AEFSKLKE----QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD---QIQTLMLQNR 1339

Query: 166  MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASELQT 222
              L   +E  D+   E       Q+   DK+  L   +EKL+E+   +  F D +   + 
Sbjct: 1340 TLLEQNMESKDLFHVE-------QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392

Query: 223  GLEISKIIMSSVSNLKH-SKEKKKS 246
            G  I+  +   + + K  ++E++KS
Sbjct: 1393 GNWITLKMRKLIKSKKDINRERQKS 1417



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 40/184 (21%), Positives = 84/184 (45%), Gaps = 25/184 (13%)

Query: 57  LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA-----------LENETNERNLAH 105
           + +  LQ +   LE E+ Q +  L +L    A +KK            +EN+  ++ L +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLK---ASFKKTERLEVSYQGLDIENQRLQKTLEN 774

Query: 106 -----QELIKQKKDISIQLSSAQSRCTLLE---KQLEYTKRMVLNVEREKNMILEQQAQL 157
                Q+L  + +D+ ++  + Q     L+   K+LE  ++   ++E+E + + + + QL
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834

Query: 158 QREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEE---KLKEEEHQRKLFQ 214
           ++E ++ + +   K   L+    +   L    KT   +I   +E   +LKE E + K   
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894

Query: 215 DKAS 218
            +A+
Sbjct: 895 KRAT 898



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 17/203 (8%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQ---YKKALENETNE---RNLAHQ 106
            ++LI    TL+     LE+E    ED  N L ++  Q    +K L+ E  +    N  H+
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234

Query: 107  ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK-EQDQ 165
             +  + K +  +        + L K+ E     VL  + +    L   ++L++ + E + 
Sbjct: 1235 TVAAEYKKLCGENDRLNHTYSQLLKETE-----VLQTDHKNLKSLLNNSKLEQTRLEAEF 1289

Query: 166  MKLYAKLEKLDV----LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
             KL  + ++LD+    L  +C  L+  +   E++ +HL ++++    Q +   ++  E +
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349

Query: 222  TGLEI-SKIIMSSVSNLKHSKEK 243
                +  +  +  ++ L+  KEK
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEK 1372



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 80/397 (20%), Positives = 161/397 (40%), Gaps = 57/397 (14%)

Query: 45   KILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA 104
            K+L S     L  +L+  +EKI  LE    ++ +    L +E    KK            
Sbjct: 955  KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK------------ 1002

Query: 105  HQELIKQKKDISIQLSSA---QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK 161
            + E +KQ++D    + S+          E++ + T R +L V+     +    A LQ EK
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062

Query: 162  EQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
            +  + +L     + + L+ +   L     + +++   L+ +  + + +      +++ L 
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122

Query: 222  TGLEISKIIMSSVSNLKHS--KEKK----------KSSKKTKCIKRRPPWQ---ICSKFG 266
                   I  SS+ N   S  KE++          K  +K + +  R   +   + SK G
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1182

Query: 267  ALPFVAEKMR-QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSE 325
             L    + +  +HRD   L+  +N    + L +  +     K +  + EK   + +N + 
Sbjct: 1183 TLKSAHKNLEVEHRD---LEDRYN----QLLKQKGQLEDLEKMLKVEQEK--MLLENKNH 1233

Query: 326  LLMAMQ-----DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI-- 378
              +A +      E D+++  + +LL   KETE   V       L+ LL   +++  ++  
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLL---KETE---VLQTDHKNLKSLLNNSKLEQTRLEA 1287

Query: 379  --SKLKKHQDSVCKLQQKVQN--SKMSEASGIQQEDS 411
              SKLK+    +     K+ N    +S+  G  +E++
Sbjct: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1324


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 80/410 (19%), Positives = 178/410 (43%), Gaps = 49/410 (11%)

Query: 35  HPANLEVTSPKILH-SPNSQALILALKTLQ----------EKIHRLELERTQAEDNLNIL 83
           H  N E+TS ++L     +Q+L   ++ L+           KI ++E E  +    + IL
Sbjct: 452 HEVN-ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510

Query: 84  SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEY-------- 135
             E  Q K++L+N  N      +E  + +K I     +++ +  +LE++ E+        
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570

Query: 136 -------TKRMVLNVEREKNMILE-------QQAQLQREKEQDQMKL---YAKLEKLDVL 178
                   +  V ++E+E  ++ E       + ++++ EK Q + +L     K E+ + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630

Query: 179 EKECFRLTTTQKTAEDKIKHLE---EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
           E E   L    +  + KI +L+   EK++  E +    + +  +L+  L+  K +   + 
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690

Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRC 295
           +L+  KE  +  ++   ++R      C+         E      +   L+K   + +   
Sbjct: 691 SLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA-S 747

Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHS 355
             K  R     + +  ++++     +N ++ +  ++ EL  + ME+Q L K ++E +  S
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807

Query: 356 VCDDIECELECLLKKMEIKGEQISKLKKH---QDSVCKLQQKVQNSKMSE 402
              +   +LE   K +E +  Q+ K KK    ++   + Q +++++ + E
Sbjct: 808 KRLE---QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 86/410 (20%), Positives = 164/410 (40%), Gaps = 72/410 (17%)

Query: 62  LQEKIHRLELERTQ--------AEDNLNI-------------LSREAAQY---------- 90
           L+ K+H +E+ER           E+N+ +             L  E  Q           
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446

Query: 91  KKALENETNE--------RNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLN 142
           +K+L +E NE          + +Q L K  +++   + S +   + + K  +  +R+   
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506

Query: 143 VEREKNMILEQQAQLQ--REKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLE 200
           VE  +N I++++  LQ  +   +D MK  A+LEK          + T ++ +E +IK LE
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---------TIETLRENSERQIKILE 557

Query: 201 EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKC-IKRRPPW 259
           +   E EH  +         Q   E     +   + + H   K+ SSK +K   ++R   
Sbjct: 558 Q---ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614

Query: 260 QICSKFGALPFVAEKMRQ-----HRDPHILQKPFNVTETRC--LPKPSRTTSWCKAIPPD 312
           +    +      AE++        ++  +LQK     +  C  +    +  S  +     
Sbjct: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674

Query: 313 SEKSISICDNLSELLMAMQDELDQMSMEHQELLK--------QMKETESHSVCDDIECEL 364
            +K++    NL+  L +++ E  Q+  E+ EL +         MK  +      ++E E 
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734

Query: 365 ECLLKKMEIKGEQISKLKKHQDSVCKL---QQKVQNSKMSEASGIQQEDS 411
           E L K +E+      K ++ + S   L    Q++Q +  +    IQQ +S
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 67/368 (18%), Positives = 160/368 (43%), Gaps = 40/368 (10%)

Query: 71  LERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLE 130
           +E ++  D L+ L   ++  +    +   +R  + Q L       S++L+ A+++   L 
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL-------SVELADAKAKIRRLR 264

Query: 131 KQLEYTKRMVLNVEREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDVLEKECFRLTT 187
           ++LE     +L+ ++E   +  +  +LQ+E      D        ++LD L ++  R+  
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-- 322

Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSS 247
                 DK++    + KE  H  + ++ +  EL+   E +++++ + + L+   E  ++ 
Sbjct: 323 ------DKLESEVSRYKERLHDIEFYKARVEELK---EDNQVLLETKTMLEDQLEGTRAR 373

Query: 248 KKTKCIKRRPPWQICSKFGALPF--------VAEKMRQHRDPHILQKPFNVTETRCLPKP 299
                   +   Q+ +K   +          + E M ++    + QK  ++ E+  L   
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ-SMDESLHLGWE 432

Query: 300 SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDD 359
               S    +    +KS+       E+       L ++ ME+Q L K ++E    +  D 
Sbjct: 433 LEQISRTSELSEAPQKSLG-----HEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDS 485

Query: 360 IECELECLLKKMEIKGEQIS-KLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKN 418
           +E     +L KME + +++S K++  ++ + + +Q +QN +      ++++    K  + 
Sbjct: 486 VEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 419 IK-NSPRK 425
           ++ NS R+
Sbjct: 545 LRENSERQ 552



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 68/319 (21%), Positives = 140/319 (43%), Gaps = 39/319 (12%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI--QL 119
            L+ K   +E+ER    +N  + + + A   +  + ET   NL  Q L  Q++ +S+  Q 
Sbjct: 1041 LKVKDRLIEVER----NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096

Query: 120  SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE------QDQMKLYAKL- 172
            ++ Q++   L+ +         ++  +   +L QQ+ L+ E E      +D   LY  L 
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156

Query: 173  ---EKLDVLEK----ECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQDKAS----EL 220
               EKL++L +    E   L +   T +   K+LE + ++ E+   +L + K      E 
Sbjct: 1157 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216

Query: 221  QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRD 280
               +E  K+++ + ++   + E KK   +   +      Q+  +   L         H++
Sbjct: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKETEVL------QTDHKN 1269

Query: 281  PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE----LDQ 336
               L     + +TR   + S+     + +   S K  + C+ LS+L   +++E    LDQ
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1329

Query: 337  ---MSMEHQELLKQMKETE 352
               + ++++ LL+Q  E++
Sbjct: 1330 IQTLMLQNRTLLEQNMESK 1348



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 18/205 (8%)

Query: 46   ILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH 105
            +L + N + +    K L  +  RL    +Q      +L  +    K  L N   E+    
Sbjct: 1226 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285

Query: 106  QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
             E  K K+    Q        T L  Q E   ++  N+E E   +L+   Q+Q    Q++
Sbjct: 1286 AEFSKLKE----QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD---QIQTLMLQNR 1338

Query: 166  MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASELQT 222
              L   +E  D+   E       Q+   DK+  L   +EKL+E+   +  F D +   + 
Sbjct: 1339 TLLEQNMESKDLFHVE-------QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391

Query: 223  GLEISKIIMSSVSNLKH-SKEKKKS 246
            G  I+  +   + + K  ++E++KS
Sbjct: 1392 GNWITLKMRKLIKSKKDINRERQKS 1416



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 40/184 (21%), Positives = 84/184 (45%), Gaps = 25/184 (13%)

Query: 57  LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA-----------LENETNERNLAH 105
           + +  LQ +   LE E+ Q +  L +L    A +KK            +EN+  ++ L +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLK---ASFKKTERLEVSYQGLDIENQRLQKTLEN 774

Query: 106 -----QELIKQKKDISIQLSSAQSRCTLLE---KQLEYTKRMVLNVEREKNMILEQQAQL 157
                Q+L  + +D+ ++  + Q     L+   K+LE  ++   ++E+E + + + + QL
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834

Query: 158 QREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEE---KLKEEEHQRKLFQ 214
           ++E ++ + +   K   L+    +   L    KT   +I   +E   +LKE E + K   
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894

Query: 215 DKAS 218
            +A+
Sbjct: 895 KRAT 898



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 17/203 (8%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQ---YKKALENETNE---RNLAHQ 106
            ++LI    TL+     LE+E    ED  N L ++  Q    +K L+ E  +    N  H+
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1233

Query: 107  ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK-EQDQ 165
             +  + K +  +        + L K+ E     VL  + +    L   ++L++ + E + 
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETE-----VLQTDHKNLKSLLNNSKLEQTRLEAEF 1288

Query: 166  MKLYAKLEKLDV----LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
             KL  + ++LD+    L  +C  L+  +   E++ +HL ++++    Q +   ++  E +
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348

Query: 222  TGLEI-SKIIMSSVSNLKHSKEK 243
                +  +  +  ++ L+  KEK
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEK 1371



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 80/397 (20%), Positives = 161/397 (40%), Gaps = 57/397 (14%)

Query: 45   KILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA 104
            K+L S     L  +L+  +EKI  LE    ++ +    L +E    KK            
Sbjct: 954  KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK------------ 1001

Query: 105  HQELIKQKKDISIQLSSA---QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK 161
            + E +KQ++D    + S+          E++ + T R +L V+     +    A LQ EK
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061

Query: 162  EQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
            +  + +L     + + L+ +   L     + +++   L+ +  + + +      +++ L 
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121

Query: 222  TGLEISKIIMSSVSNLKHS--KEKK----------KSSKKTKCIKRRPPWQ---ICSKFG 266
                   I  SS+ N   S  KE++          K  +K + +  R   +   + SK G
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181

Query: 267  ALPFVAEKMR-QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSE 325
             L    + +  +HRD   L+  +N    + L +  +     K +  + EK   + +N + 
Sbjct: 1182 TLKSAHKNLEVEHRD---LEDRYN----QLLKQKGQLEDLEKMLKVEQEK--MLLENKNH 1232

Query: 326  LLMAMQ-----DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI-- 378
              +A +      E D+++  + +LL   KETE   V       L+ LL   +++  ++  
Sbjct: 1233 ETVAAEYKKLCGENDRLNHTYSQLL---KETE---VLQTDHKNLKSLLNNSKLEQTRLEA 1286

Query: 379  --SKLKKHQDSVCKLQQKVQN--SKMSEASGIQQEDS 411
              SKLK+    +     K+ N    +S+  G  +E++
Sbjct: 1287 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 40/307 (13%)

Query: 102  NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
            N+ H   +K    I   L SA++   +  ++++ + TK  +   E ++  + E+   L +
Sbjct: 824  NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQ 883

Query: 160  EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
            EK   Q+++ A+ E L   E+ C +L   +   E KIK + E+ ++EE        +++ 
Sbjct: 884  EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK 943

Query: 213  FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
             +D+ SEL+  ++  ++ ++ V   KH+ E K  +             +  +   L    
Sbjct: 944  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEELSGLDETI 990

Query: 273  EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
             K+ + +      K       + L            +  + +K  S+    S+L   ++D
Sbjct: 991  AKLTREK------KALQEAHQQALDD----------LQAEEDKVNSLNKTKSKLEQQVED 1034

Query: 333  ELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQ 392
               + S+E ++ L+   E     +  D++   E +L     K +   +LKK     C+LQ
Sbjct: 1035 L--ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQ 1092

Query: 393  QKVQNSK 399
             KV++ +
Sbjct: 1093 SKVEDEQ 1099



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 81/382 (21%), Positives = 166/382 (43%), Gaps = 51/382 (13%)

Query: 55   LILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
            LI A   L+ KI  +  ER + E+ +N    E    K+ LE+E +E           KKD
Sbjct: 909  LIKAKFQLEAKIKEVT-ERAEDEEEINA---ELTAKKRKLEDECSEL----------KKD 954

Query: 115  IS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLE 173
            I  ++L+ A+     +EK+   T+  V N+  E + + E  A+L REK+  Q      L+
Sbjct: 955  IDDLELTLAK-----VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009

Query: 174  KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSS 233
             L   E +   L  T+   E +++ LE  L++E+  R   +    +L+  L++++  +  
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069

Query: 234  VSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTET 293
            + N K   +++   K  +  + +   +     G       K  Q R   + ++      T
Sbjct: 1070 LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129

Query: 294  RCLPKPSRTTSWCKAIPPDSEK----------SISICDNLSELLMAMQDELDQMSMEHQE 343
            R   +  R + + + +   SE+           I +        + ++ +L++ +++H+ 
Sbjct: 1130 RAKTEKQR-SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188

Query: 344  LLKQMKETESHSVC------DDIECELECLLK-----KMEIKG-----EQISKLKKHQDS 387
            ++  +++  + SV       D+++   + L K     K+EI       E +SK K + + 
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248

Query: 388  VCKLQQKVQNSKMSEASGIQQE 409
            +C+  +     ++SEA G  +E
Sbjct: 1249 ICRTLE----DQLSEARGKNEE 1266



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 83/442 (18%), Positives = 175/442 (39%), Gaps = 24/442 (5%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            E +++    N E+T+ K         L   +  L+  + ++E E+   E+ +  L+ E +
Sbjct: 925  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 984

Query: 89   QYKKALENETNERNL---AHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVER 145
               + +   T E+     AHQ+ +   +    +++S     + LE+Q+E  +    ++E+
Sbjct: 985  GLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES---SLEQ 1041

Query: 146  EKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKE 205
            EK +    +  L+R K + +  L    E +  LE +  +L    K  + +   L+ K+++
Sbjct: 1042 EKKL----RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED 1097

Query: 206  EEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICS 263
            E+     FQ K  ELQ  +E    +I     +  K  K++   +++ + +  R       
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSER-----LE 1152

Query: 264  KFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNL 323
            + G +     ++ + R+   L+   ++ E     +        K     +E    I DNL
Sbjct: 1153 EAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI-DNL 1211

Query: 324  SELLMAMQDELDQMSMEHQELLKQMKETES-----HSVCDDIECELECLLKKMEIKGEQI 378
              +   ++ E  +  +E  +L   M+           +C  +E +L     K E     +
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271

Query: 379  SKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSS 438
            S+L   Q S  + +    + ++ E   I  + S  K +   +    K   +     KN+ 
Sbjct: 1272 SELTT-QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL 1330

Query: 439  FHPIRVHNLQMKLRRDDIMWEQ 460
             H ++       L R+    EQ
Sbjct: 1331 AHALQSSRHDCDLLREQYEEEQ 1352



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 75/371 (20%), Positives = 148/371 (39%), Gaps = 71/371 (19%)

Query: 62   LQEKIHRLELERTQAEDN----------LNILSREAAQYKKALENE----TNERNLAHQE 107
            LQ   H  +L R Q E+           L+  + E AQ++   E +    T E   A ++
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393

Query: 108  LIKQKKDISIQLSSAQSRCTLLEKQLE----YTKRMVLNVEREKNM--ILEQQ------- 154
            L ++ +D   Q+ +  ++C  LEK  +      + ++++VER  ++   L+++       
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453

Query: 155  -AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF 213
             A+ + + E+ Q +L A L++   L  E F+L    + A D+++ ++ + K  E      
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ----- 1508

Query: 214  QDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
                       EI+ +      N K   E +KS K+ +  K        +        AE
Sbjct: 1509 -----------EIADLTEQIAENGKTIHELEKSRKQIELEK--------ADIQLALEEAE 1549

Query: 274  KMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE 333
               +H +  IL+    +T+ +        +   + I    E+   +  N    +  MQ  
Sbjct: 1550 AALEHEEAKILRIQLELTQVK--------SEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601

Query: 334  LDQMSMEHQELLKQMKETESHSVCDDIECEL--------ECLLKKMEIKGEQISKLKKHQ 385
            LD       E ++  K+ E     ++IE +L        E L     ++G Q+   + H 
Sbjct: 1602 LDAEVRSRNEAIRLKKKMEGD--LNEIEIQLSHANRQAAETLKHLRSVQG-QLKDTQLHL 1658

Query: 386  DSVCKLQQKVQ 396
            D   + Q+ ++
Sbjct: 1659 DDALRGQEDLK 1669



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 20/203 (9%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELI 109
            +A +   ++L  ++ +L+    +A D L  + RE    ++ + + T    E      EL 
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE 1528

Query: 110  KQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLY 169
            K +K I ++ +  Q      E  LE+          E+  IL  Q +L + K +   K+ 
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEH----------EEAKILRIQLELTQVKSEIDRKIA 1578

Query: 170  AKLEKLDVLEKECFRLTTTQKTAED-KIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
             K E+++ L++   R   T ++A D +++   E ++     +K  +   +E++  +++S 
Sbjct: 1579 EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR----LKKKMEGDLNEIE--IQLSH 1632

Query: 229  IIMSSVSNLKHSKEKKKSSKKTK 251
                +   LKH +  +   K T+
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQ 1655



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 68/344 (19%), Positives = 142/344 (41%), Gaps = 48/344 (13%)

Query: 71   LERTQAEDNLNILSR-EAAQYKKALENETNE-------------RNLAHQELIK-QKKDI 115
            +E  Q+  +  + SR EA + KK +E + NE               L H   ++ Q KD 
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654

Query: 116  SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
             + L  A      L++QL   +R    ++ E   +     Q +R ++  + +L    E++
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714

Query: 176  DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT-GLEISKIIMSSV 234
             +L  +   L  T+K  E  +  L+ ++++     +  ++KA +  T    +++ +    
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774

Query: 235  SNLKHSKEKKKSSKKT-KCIKRR--PPWQICSKFGALPFVAEKMRQHRDPHILQKPF--- 288
                H +  KK+ ++T K ++ R     Q+  K G      +K  Q  +  I +  F   
Sbjct: 1775 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG------KKQIQKLETRIRELEFELE 1828

Query: 289  -----NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQE 343
                 N    + L K  R     K +   SE+         + ++ +QD +D++ ++ + 
Sbjct: 1829 GEQKKNTESVKGLRKYERRV---KELTYQSEED-------RKNVLRLQDLVDKLQVKVKS 1878

Query: 344  LLKQMKETESHSVCD-----DIECELECLLKKMEIKGEQISKLK 382
              +Q +E +  +          + ELE   ++ +I   Q++KL+
Sbjct: 1879 YKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLR 1922


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 64/345 (18%), Positives = 151/345 (43%), Gaps = 33/345 (9%)

Query: 57  LALKTLQEKIHR--LELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
           L +K L+ K+ R  L L + Q +   + L +E       L+ +  E  L ++   +Q++ 
Sbjct: 230 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 289

Query: 115 ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEK 174
           +  Q    Q R   +++Q E  +     + R++ M+ E++ +++R++E     ++ K EK
Sbjct: 290 MWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM----MWEKEEK 345

Query: 175 LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV 234
           +  LE++           ++KI+  EEK +EEE  R+  + +  E +   +  KI     
Sbjct: 346 IRELEEKMHE--------QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI-REQE 396

Query: 235 SNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
             ++  +E  +  ++    +    W+   +   +    EKMR+       ++     E +
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWE---QEEEMQEQEEKMRRQ------EEKIREQEKK 447

Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
              +  +     + +    EK       + E    MQ++ ++M  + +++ +Q K+    
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507

Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSK 399
                     E + ++ E+  EQ  K+ + ++ +C+ ++K+Q  +
Sbjct: 508 E---------EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 67/392 (17%), Positives = 162/392 (41%), Gaps = 56/392 (14%)

Query: 58  ALKTLQEKIHRLELERTQAEDNL------NILSREAAQYKKA--------LENETNERNL 103
           A+ T ++K  R   E T+  D L      N ++ E  + K A        +E+E +E  L
Sbjct: 171 AVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQL 230

Query: 104 AHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQ 163
             +EL ++ +   + L   Q     L+ + ++  + + +V  +    +E+     R  +Q
Sbjct: 231 NVKELKRKLERAKLLLPQQQ-----LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 285

Query: 164 DQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG 223
            + K++ + EK+   E++        +  E+K++  EE + E+E + +  ++   E +  
Sbjct: 286 QEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 345

Query: 224 LEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHI 283
           +   +  M     ++  +EK++  +K +                     ++ RQ ++  +
Sbjct: 346 IRELEEKMHEQEKIREQEEKRQEEEKIR--------------------EQEKRQEQEAKM 385

Query: 284 LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQE 343
            ++   + E     +  +     + +    EK     + + E    MQ++ ++M  + ++
Sbjct: 386 WRQEEKIRE-----QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440

Query: 344 LLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEA 403
           + +Q K+         I  + E + ++ E+  EQ  K+ + +  +C+ + K+Q     E 
Sbjct: 441 IREQEKK---------IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE---QEE 488

Query: 404 SGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQK 435
              +QE+   +  K I+    K      + Q+
Sbjct: 489 KMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 52/299 (17%), Positives = 124/299 (41%), Gaps = 29/299 (9%)

Query: 63  QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
           +EKI   E E+ Q ++       E  + ++ +  E  E+    +E++ +K++   +L   
Sbjct: 294 EEKIQERE-EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-- 350

Query: 123 QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKEC 182
                  EK  E  K      E+E+    E++ + Q ++++ + K++ + EK+   E++ 
Sbjct: 351 -------EKMHEQEKIR----EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399

Query: 183 FRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL-EISKIIMSSVSNLKHSK 241
                  +  E+K+   EEK+ E+E + +  ++K    +  + E  K I      ++  +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 459

Query: 242 EKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMR------QHRDPHILQKPFNVTETRC 295
           E  +  ++          ++C +   +    EKMR      + ++  I ++   + E   
Sbjct: 460 EMMQEQEEK---MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516

Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
           + +      W        EK     + + E    M+ + ++M  +   L +Q ++ + H
Sbjct: 517 MMQEQEEKMW-----EQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 29/140 (20%), Positives = 59/140 (42%), Gaps = 16/140 (11%)

Query: 321 DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISK 380
           + L E    +Q++L  +  E  E+   +KE +            + LL + +++ E    
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE------RAKLLLPQQQLQAEADHL 258

Query: 381 LKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFH 440
            K+ Q    KLQ +V+ +++      QQE+   +  + I+    K               
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKI---------QEQEE 309

Query: 441 PIRVHNLQMKLRRDDIMWEQ 460
            IR    +M+ R++++MWE+
Sbjct: 310 KIREQEEKMR-RQEEMMWEK 328


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 57/291 (19%), Positives = 123/291 (42%), Gaps = 38/291 (13%)

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
            ++ + A+     +++  E TK  +   E  +  + E+   L +EK   Q+++ ++ E L 
Sbjct: 844  LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKASELQTGLEISKI 229
              E+ C  L  ++   E K+K L E+L+EEE        +++  +DK S L+  ++  ++
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963

Query: 230  IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFN 289
             ++ V   KH+ E K  +             +  +  AL     K+ +            
Sbjct: 964  TLTKVEKEKHATENKVKN-------------LSEEMTALEENISKLTK------------ 998

Query: 290  VTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
              E + L +  + T     +  D    +     ++  L    D+L+  S+E ++ L+   
Sbjct: 999  --EKKSLQEAHQQTLDDLQVEEDKVNGLI---KINAKLEQQTDDLEG-SLEQEKKLRADL 1052

Query: 350  ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKM 400
            E     +  D++   E ++     K +   KLKK +  + +LQ K+ + ++
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 73/342 (21%), Positives = 150/342 (43%), Gaps = 28/342 (8%)

Query: 63   QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
            + K+  L  E T  E+N++ L++E    KK+L+        AHQ+ +    D+ ++    
Sbjct: 976  ENKVKNLSEEMTALEENISKLTKE----KKSLQE-------AHQQTLD---DLQVEEDKV 1021

Query: 123  QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKEC 182
                 +  K  + T  +  ++E+EK +    +A L+R K + +  L    E +  LE + 
Sbjct: 1022 NGLIKINAKLEQQTDDLEGSLEQEKKL----RADLERAKRKLEGDLKMSQESIMDLENDK 1077

Query: 183  FRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKE 242
             ++    K  E ++  L+ K+ +E+     FQ K  ELQ  +E  +  + +   L+   E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137

Query: 243  KKKS--SKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
            K++S  +++ + I  R    +    GA     E M + R+    +   ++ E     + +
Sbjct: 1138 KQRSDLARELEEISER----LEEASGATSAQIE-MNKKREAEFQKMRRDLEEATLQHEAT 1192

Query: 301  RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
              T   K     +E    I DNL  +   ++ E  ++ ME  ++   ++         + 
Sbjct: 1193 AATLRKKQADSVAELGEQI-DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251

Query: 361  ECE-LECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMS 401
             C  +E    +++ K EQ ++L  H  ++ K + + QN ++S
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQL-IHDLNMQKARLQTQNGELS 1292



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 68/378 (17%), Positives = 144/378 (38%), Gaps = 34/378 (8%)

Query: 92   KALENETNERNLAHQELIKQKKDISIQLSSAQS-------RCTLLEKQLEYTKRMVLNVE 144
            K L     E    + EL+ +K+++  + SS +          T +EK+   T+  V N+ 
Sbjct: 924  KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983

Query: 145  REKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLK 204
             E   + E  ++L +EK+  Q      L+ L V E +   L       E +   LE  L+
Sbjct: 984  EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043

Query: 205  EEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRP------- 257
            +E+  R   +    +L+  L++S+  +  + N K   E+K   K+ +  + +        
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103

Query: 258  -PWQICSKFGALPFVAEKMRQHRD-PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
               Q   K   L    E++ +  +  H L+       +    +    +   +     +  
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163

Query: 316  SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
             I +          M+ +L++ +++H+     +++ ++ SV +                G
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE---------------LG 1208

Query: 376  EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQK 435
            EQI  L++ +    KL+++    KM         ++  K   NI+ + R      +  + 
Sbjct: 1209 EQIDNLQRVKQ---KLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265

Query: 436  NSSFHPIRVHNLQMKLRR 453
                    +H+L M+  R
Sbjct: 1266 KDEQQTQLIHDLNMQKAR 1283



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 71/394 (18%), Positives = 163/394 (41%), Gaps = 60/394 (15%)

Query: 62   LQEKIHRLELERTQAEDN----------LNILSREAAQYKKALENE----TNERNLAHQE 107
            LQ   H  +L R Q E+           L+  + E AQ++   E +    T E   A ++
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396

Query: 108  LIKQKKDISIQLSSAQSRCTLLEK--------------QLEYTKRMVLNVEREKNMILEQ 153
            L ++ ++      +A S+C  LEK               LE +      +++++    + 
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV 1456

Query: 154  QAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF 213
             A+ +++ ++ Q +L A  ++   L  E F++    +   D+++ L  + K  + +    
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516

Query: 214  QDKASE----LQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALP 269
             ++ +E    LQ   +  K++    S+L+ + E+ + S + +           SK   + 
Sbjct: 1517 TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE----------SKILRVQ 1566

Query: 270  FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMA 329
                +++   D  +++K   + +   L + S+  +  +A+    +  I   ++   L   
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQ---LKRNSQRAA--EALQSVLDAEIRSRNDALRLKKK 1621

Query: 330  MQDELDQMSMEHQELLKQMKETESH-----SVCDDIECELECLLKKMEIKGEQIS----- 379
            M+ +L++M ++     +QM ET+ H         D +  L+  L+  E   EQ++     
Sbjct: 1622 MEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR 1681

Query: 380  ---KLKKHQDSVCKLQQKVQNSKMSEASGIQQED 410
                L++ ++    L+Q  +  ++SE   +   D
Sbjct: 1682 NGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 64/356 (17%), Positives = 140/356 (39%), Gaps = 42/356 (11%)

Query: 72   ERTQAEDNLNI---------------------LSREAAQYKKALENETNERNLAHQELIK 110
            ++TQ   +LN+                     L  +  + K+AL  +  E     +E  K
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328

Query: 111  QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
             K  ++  L S++  C LL +Q E  +     ++R  +    + AQ + + E D      
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD------ 1382

Query: 171  KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
             +++ + LE+   +L    + AE+  +    K    E  ++  Q +  +L   LE S   
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 231  MSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFG-ALPFVAEKMRQHRDPHILQKPFN 289
             +++   + + +K  +  K K  + +   +   K   +L     KMR   +  + Q    
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

Query: 290  VTETRCLPK-----PSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQEL 344
              E + L +       +     K +    +    +    S+L +A+++    +  E  ++
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562

Query: 345  LKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKM 400
            L+   E         ++ EL+   +K+  K E+I +LK++     +  Q V ++++
Sbjct: 1563 LRVQLE------LSQVKSELD---RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEI 1609



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 73/393 (18%), Positives = 162/393 (41%), Gaps = 45/393 (11%)

Query: 60   KTLQEKIHRL--ELERT-----QAEDNLNILSREAAQYKKALENETNERNLAHQE--LIK 110
            K LQE+I  L  ++  T     +AE    ++ +E +  + ALE    E +L H+E  +++
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV--EGSLEHEESKILR 1564

Query: 111  QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
             + ++S   S    +    ++++E  KR           +L+ + + + +  + + K+  
Sbjct: 1565 VQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624

Query: 171  KLEKLDV--------LEKECFRLTTTQKTAEDKIKHLEEKLKEEE---HQRKLFQDKASE 219
             L ++++        + +    L T Q   +D   HL++ L+  E    Q  + + +   
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684

Query: 220  LQTGLEISKIIMSSVSNLKHSKEKK--KSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ 277
            L   LE  K+ +      +   E++   +S + + +  +    I +K      +A+   Q
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ--CQ 1742

Query: 278  HRDPHILQKPFNVTE--TRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ---D 332
                + +Q+  N  E   + +   +      K     S     +  NL + +  +Q   D
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802

Query: 333  ELDQMSMEHQELLKQMKETESHSVCDDIECE-------------LECLLKKMEIKGEQIS 379
            E +Q++++  +   Q  E     + ++++ E              E  +K+M  + E+  
Sbjct: 1803 EAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDH 1862

Query: 380  K-LKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
            K + + QD V KLQ KV++ K       +Q ++
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 35/148 (23%), Positives = 67/148 (45%), Gaps = 12/148 (8%)

Query: 38   NLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENE 97
            NLE T   + H  + +A  LALK  +++I +LE    + E+ L++  +  A+  K     
Sbjct: 1789 NLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK- 1846

Query: 98   TNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQL 157
              ER +  +E+  Q ++    +   Q     L+ +++  KR     E + N  L +  ++
Sbjct: 1847 -YERKV--KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903

Query: 158  QREKEQDQMKLYAKLEKLDVLEKECFRL 185
            Q E E+         E+ D+ E +  +L
Sbjct: 1904 QHELEE-------AAERADIAESQVNKL 1924


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 91/416 (21%), Positives = 180/416 (43%), Gaps = 73/416 (17%)

Query: 32  QNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYK 91
           Q C    LE+T  +     + +A     K LQ ++ +L+    +A+    + +++AAQ K
Sbjct: 289 QQCMATELEMTVKEAKQDKSKEA---ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 345

Query: 92  K-----ALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
           +         E  +R L    L+ ++K  +IQ          L+++L+        +++E
Sbjct: 346 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE---------LQRELQM-------LQKE 389

Query: 147 KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAE-------DKIKH- 198
            +M  ++Q   ++  E+  ++L   L KL+  +KE  +L  T    +       D+IKH 
Sbjct: 390 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 449

Query: 199 ------LEEKLKEE-EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
                 ++ KL+E+ +   KL +DK  +L+   E  K++   +  L+   +KK  + K  
Sbjct: 450 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 509

Query: 252 CIK-------RRPPWQICS--------KFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
             K        R   Q CS        K+     V + + +      LQK   ++    L
Sbjct: 510 SRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKE---IALQKESLMSLQAQL 566

Query: 297 PKP-------SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
            K         +TT   +A    S KS +  D+L++ L    ++L+ ++ E + L + + 
Sbjct: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLT 622

Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEAS 404
           +T+       +E E+    ++M+    ++ KL+  HQ+S  +L+    + K+ E S
Sbjct: 623 QTQEKKA--QLEEEIIAYEERMKKLNTELRKLRGFHQES--ELEVHAFDKKLEEMS 674



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 84/402 (20%), Positives = 181/402 (45%), Gaps = 41/402 (10%)

Query: 68  RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
           R+ELE   +E   NI+ ++  + +  L     E   AH E  ++ KDI+I       +C 
Sbjct: 188 RVELEAV-SEQKRNIM-KDMMKLELDLHG-LREETSAHIE--RKDKDITIL------QCR 236

Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT- 186
           L E QLE+T+   L ++++K +  + +   + EK+  Q++  + L+K   LEK+    T 
Sbjct: 237 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-NSLLKKEKELEKQQCMATE 295

Query: 187 ---TTQKTAEDKIKHLEEKLKEEEHQR---KLFQDKASELQTGLEISKIIMSSVSNLKHS 240
              T ++  +DK K  E K  + E Q+    L + K  E     + ++    +     H 
Sbjct: 296 LEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL 355

Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
           ++ ++  +K   + ++    I                 R+  +LQK  ++ E        
Sbjct: 356 EDTQRKLQKGLLLDKQKADTI-------------QELQRELQMLQKESSMAEKEQTSNRK 402

Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK--ETESHSVCD 358
           R     + +  +  +++   +N  +    +Q  + +  M+  ++L ++K    E  S+  
Sbjct: 403 RV----EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 458

Query: 359 DIECELECLLKKMEIKGEQISKLKKHQDSV-CKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
            +E +L+   K +E K EQ+ K K+H+  +  +L+   Q  K  + +  +      + ++
Sbjct: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518

Query: 418 NIKNSPRKCLT--DTNLFQKNSSFHPIRVHNLQMKLRRDDIM 457
           N++   + C T  +++L + N+S   I+  N ++ L+++ +M
Sbjct: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 560



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 40/165 (24%), Positives = 78/165 (47%), Gaps = 23/165 (13%)

Query: 60  KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
           K LQ++ H L+   T  ++  + LSR++A  +  L     + N     +  + K +   L
Sbjct: 568 KALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLN----HVTSETKSLQQSL 621

Query: 120 SSAQSRCTLLEKQL-EYTKRMV-LNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
           +  Q +   LE+++  Y +RM  LN E  K     Q+++L+         ++A  +KL+ 
Sbjct: 622 TQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE---------VHAFDKKLE- 671

Query: 178 LEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASE 219
            E  C ++   QK  ++ +K L   EE+L+E + +    ++   E
Sbjct: 672 -EMSC-QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE 714


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 91/416 (21%), Positives = 180/416 (43%), Gaps = 73/416 (17%)

Query: 32  QNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYK 91
           Q C    LE+T  +     + +A     K LQ ++ +L+    +A+    + +++AAQ K
Sbjct: 434 QQCMATELEMTVKEAKQDKSKEA---ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 490

Query: 92  K-----ALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
           +         E  +R L    L+ ++K  +IQ          L+++L+        +++E
Sbjct: 491 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE---------LQRELQM-------LQKE 534

Query: 147 KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAE-------DKIKH- 198
            +M  ++Q   ++  E+  ++L   L KL+  +KE  +L  T    +       D+IKH 
Sbjct: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594

Query: 199 ------LEEKLKEE-EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
                 ++ KL+E+ +   KL +DK  +L+   E  K++   +  L+   +KK  + K  
Sbjct: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 654

Query: 252 CIK-------RRPPWQICS--------KFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
             K        R   Q CS        K+     V + + +      LQK   ++    L
Sbjct: 655 SRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKE---IALQKESLMSLQAQL 711

Query: 297 PKP-------SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
            K         +TT   +A    S KS +  D+L++ L    ++L+ ++ E + L + + 
Sbjct: 712 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLT 767

Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEAS 404
           +T+       +E E+    ++M+    ++ KL+  HQ+S  +L+    + K+ E S
Sbjct: 768 QTQEKKA--QLEEEIIAYEERMKKLNTELRKLRGFHQES--ELEVHAFDKKLEEMS 819



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 84/402 (20%), Positives = 181/402 (45%), Gaps = 41/402 (10%)

Query: 68  RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
           R+ELE   +E   NI+ ++  + +  L     E   AH E  ++ KDI+I       +C 
Sbjct: 333 RVELEAV-SEQKRNIM-KDMMKLELDLHG-LREETSAHIE--RKDKDITIL------QCR 381

Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT- 186
           L E QLE+T+   L ++++K +  + +   + EK+  Q++  + L+K   LEK+    T 
Sbjct: 382 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-NSLLKKEKELEKQQCMATE 440

Query: 187 ---TTQKTAEDKIKHLEEKLKEEEHQR---KLFQDKASELQTGLEISKIIMSSVSNLKHS 240
              T ++  +DK K  E K  + E Q+    L + K  E     + ++    +     H 
Sbjct: 441 LEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL 500

Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
           ++ ++  +K   + ++    I                 R+  +LQK  ++ E        
Sbjct: 501 EDTQRKLQKGLLLDKQKADTI-------------QELQRELQMLQKESSMAEKEQTSNRK 547

Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK--ETESHSVCD 358
           R     + +  +  +++   +N  +    +Q  + +  M+  ++L ++K    E  S+  
Sbjct: 548 RV----EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 603

Query: 359 DIECELECLLKKMEIKGEQISKLKKHQDSV-CKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
            +E +L+   K +E K EQ+ K K+H+  +  +L+   Q  K  + +  +      + ++
Sbjct: 604 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 663

Query: 418 NIKNSPRKCLT--DTNLFQKNSSFHPIRVHNLQMKLRRDDIM 457
           N++   + C T  +++L + N+S   I+  N ++ L+++ +M
Sbjct: 664 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 705



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 69/338 (20%), Positives = 137/338 (40%), Gaps = 38/338 (11%)

Query: 60  KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
           KTL+E   +LE E       L   S +       LE+  N+ N + Q +    K+I++Q 
Sbjct: 649 KTLKENSRKLEEENENLRAELQCCSTQ-------LESSLNKYNTSQQVIQDLNKEIALQK 701

Query: 120 SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLE 179
            S  S    L+K L+  K  +     +  +  E    L R+    Q  L   LEKL+   
Sbjct: 702 ESLMSLQAQLDKALQKEKHYL-----QTTITKEAYDALSRKSAACQDDLTQALEKLN--- 753

Query: 180 KECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKH 239
                +T+  K+ +  +   +EK  + E +   ++++  +L T L   +          H
Sbjct: 754 ----HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVH 809

Query: 240 SKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR---CL 296
           + +KK      + ++ +   Q  +    L    E++R+ ++     K   + + +   CL
Sbjct: 810 AFDKKLEEMSCQVLQWQKQHQ--NDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCL 867

Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM-----KET 351
           P+ S     C+    + +    I  NL +     +   +++  + +E +K +     ++ 
Sbjct: 868 PQWSVPKDTCRLYRGNDQ----IMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD 923

Query: 352 ESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVC 389
             HSV   ++ E + L K++E K     K+K     +C
Sbjct: 924 HLHSVMVHLQQENKKLKKEIEEK-----KMKAENTRLC 956



 Score = 35.8 bits (81), Expect = 0.084
 Identities = 73/393 (18%), Positives = 152/393 (38%), Gaps = 58/393 (14%)

Query: 51  NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH----- 105
           + Q  +  L+ L++K+  L+ E     + L        QY+  LE +T++  L H     
Sbjct: 75  SKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKL 134

Query: 106 --QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQ 163
              E+I  ++++     +   +  L ++QL      + ++ER  N        L R+K Q
Sbjct: 135 KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLN--------LYRDKYQ 186

Query: 164 DQMKLYAKLE-KLDVLEKECFRLTTTQ---KTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
             +     LE ++ +L+ E   +   +   K    K++        +EHQ    Q + SE
Sbjct: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQET--QKRLSE 244

Query: 220 LQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHR 279
           +   +     ++  + N           ++   IK +  +  C+              HR
Sbjct: 245 VWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCT------------ATHR 292

Query: 280 DPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSM 339
            P     P +  E   + K        K +    +      +    L+  ++ EL+ +S 
Sbjct: 293 YP-----PSSSEECEDIKK------ILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 341

Query: 340 EHQELLKQM-----------KETESHSVCDDIECE-LECLLKKMEIKGEQISKLKKHQDS 387
           + + ++K M           +ET +H    D +   L+C L++++++  +  KL   +D 
Sbjct: 342 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 401

Query: 388 VCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
              LQ+K +  +  E    Q ++S  K  K ++
Sbjct: 402 F--LQEKDEMLQELEKKLTQVQNSLLKKEKELE 432


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 79/357 (22%), Positives = 157/357 (43%), Gaps = 70/357 (19%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN--ERNLAHQ--EL 108
            Q L+ A   LQE    LE E+ Q ++   +LSR+    K+A++ E    E+ L  +  +L
Sbjct: 1950 QELLCASNRLQE----LEAEQQQIQEERELLSRQ----KEAMKAEAGPVEQQLLQETEKL 2001

Query: 109  IKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKL 168
            +K+K ++  Q    +     L+KQ+   K + ++VE + +  +E    L++EK  + M L
Sbjct: 2002 MKEKLEVQCQAEKVRDD---LQKQV---KALEIDVEEQVSRFIE----LEQEKNTELMDL 2051

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
              + + L+             K  E   K L+E+  + EH+R +FQ +  +L+  L++  
Sbjct: 2052 RQQNQALE-------------KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098

Query: 229  IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
                   +     E+  +  K K  K       CS+        ++  Q R+  I +  F
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDK-------CSELLLSKEQLQRDIQERNEEIEKLEF 2151

Query: 289  NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM 348
             V E              +A+  +  K     +   EL + +Q + ++ +++ +E     
Sbjct: 2152 RVRELE------------QALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----- 2194

Query: 349  KETESHSVCDDIECELECLLKKMEIKGEQISKLK-----KHQDSVCKLQQKVQNSKM 400
            KE        ++E +LE   +++E K E++ +L      + ++S  +LQ+  Q +K+
Sbjct: 2195 KE------ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKL 2245



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 46/213 (21%), Positives = 103/213 (48%), Gaps = 21/213 (9%)

Query: 54   ALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKK 113
            +L + L+  ++ I R E E T  E+ L        Q+++ LEN+  E    H +L  QKK
Sbjct: 2178 SLEVQLQAERDAIDRKEKEITNLEEQLE-------QFREELENKNEEVQQLHMQLEIQKK 2230

Query: 114  DISIQLSSAQSRCTLLEKQLEYTKRMVLNVE----REKNMILEQQAQLQREKEQDQMKLY 169
            + + +L   +    L +  +E     +   +    ++++++  + AQ+ +EKE +  +L 
Sbjct: 2231 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2290

Query: 170  AKLEKLDVLEKECFRLTTTQKTAEDK---IKHLEEKLK-EEEHQRKLFQDKASELQTGLE 225
             ++ KL    ++  ++TT  K  E+K   I+ LE +++     Q  + +++  E++   E
Sbjct: 2291 EQVTKL----QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346

Query: 226  ISKIIMSSVSNL--KHSKEKKKSSKKTKCIKRR 256
            + + +   ++N+  K S      S++   +K +
Sbjct: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 82/380 (21%), Positives = 162/380 (42%), Gaps = 39/380 (10%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            QA +  L+    +    E++   A+ N   ++ +  Q  +    E  E N+  ++   Q 
Sbjct: 3068 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ--SQM 3125

Query: 113  KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE---KNMILEQ--QAQLQREKEQDQMK 167
             ++ ++LSS + R T L++QL   K +V  ++ E     + LE   +AQ +  KE +  +
Sbjct: 3126 LEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFR 3185

Query: 168  LYAKLEKLDVLEKECFRLTTTQKTAED----------KIKHLEEKLKEEEHQRKLFQDKA 217
            L  K +K D +      L + QK + +          K+   EE+ KEE    K   +  
Sbjct: 3186 LEVK-DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE-- 3242

Query: 218  SELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIK------RRPPWQIC--SKFGALP 269
            S+ Q  L+++ ++      L  S++K +S +     +      R    Q+   S+   + 
Sbjct: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3302

Query: 270  FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPD-SEKSISICDNLSELLM 328
             ++  + + R+ H   +  + T     P PS      K +     EK   I + L+E   
Sbjct: 3303 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSE--DLLKELQKQLEEKHSRIVELLNETEK 3360

Query: 329  AMQDELD-QMSME-----HQELLKQMKE--TESHSVCDDIECELECLLKKMEIKGEQISK 380
               D L  +  ME     H++ L+  +E  TE      +++ ++E L +++E K +Q+ K
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420

Query: 381  LKKHQDSVCKLQQKVQNSKM 400
            L      +  + Q+ Q  ++
Sbjct: 3421 LDLEGQRLQGIMQEFQKQEL 3440



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 76/374 (20%), Positives = 156/374 (41%), Gaps = 51/374 (13%)

Query: 57  LALKTLQEKIHRLELER--TQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
           L  K ++E+   LEL+   T A+  L  L  +  Q  + ++N   E   + Q+  +  ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393

Query: 115 ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ-QAQLQREKEQDQMKLYAKLE 173
           I   + + +       K  ++   +V  +E+E    LEQ +A+L     Q  +++  +L 
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453

Query: 174 KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSS 233
           +  + + E   + T  K   +        +   E Q KL     +EL   L+       +
Sbjct: 454 RQHMAQME--EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ------DT 505

Query: 234 VSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTET 293
            S  +  KE+     + KC  +R   Q+      L F  E++++ R   I ++   + E 
Sbjct: 506 NSQKEKLKEELGLILEEKCALQR---QLEDLVEELSFSREQIQRARQT-IAEQESKLNE- 560

Query: 294 RCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQ------ELLKQ 347
                              + KS+S  ++L   +++  +   ++ ++H+      ++  +
Sbjct: 561 -------------------AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601

Query: 348 MKETESHSVCDDI----ECELECLLKKMEIK-GEQISKLK-----KHQDSVCKLQQKVQN 397
           M E E ++V D +    E ELE L  ++     E++SKLK     +H+ ++ KL+  +  
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661

Query: 398 SKMSEASGIQQEDS 411
               +  G+Q E S
Sbjct: 662 HYKQQIDGLQNEMS 675



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 64/269 (23%), Positives = 109/269 (40%), Gaps = 20/269 (7%)

Query: 52   SQALILALKTLQEKIHRLE-LERTQAED---NLNILSREAAQYKKALENETNERNLAHQE 107
            S+ L  AL+  + K+ R E  ++ + ED   +L    +   Q    LE +    N + Q+
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK 3268

Query: 108  LIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMK 167
            +  Q+     QLS  Q R   L+  LE  K  +  +    +   E  AQLQ      Q +
Sbjct: 3269 IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR 3328

Query: 168  -------LYAKLEKLDVLEKECFR----LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDK 216
                   L  +L+K   LE++  R    L  T+K   D ++  ++  K+ +  RK  Q +
Sbjct: 3329 PPLPSEDLLKELQK--QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3386

Query: 217  ASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMR 276
                  G +    + S V +L+   E+K+       ++ +    I  +F       E+ R
Sbjct: 3387 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR 3446

Query: 277  QHRDPHILQKPFNVTETRCLPKPSRTTSW 305
            + R   IL +  N   T  L    RT +W
Sbjct: 3447 ESR--RILYQNLNEPTTWSLTS-DRTRNW 3472



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 51/197 (25%), Positives = 91/197 (46%), Gaps = 27/197 (13%)

Query: 37  ANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNI--------LSREAA 88
           A LE    ++L S   +  +  LK   E  HR+ +E+ +  DNL I        L  E +
Sbjct: 620 AELERLRTQLLFSHEEE--LSKLKEDLEIEHRINIEKLK--DNLGIHYKQQIDGLQNEMS 675

Query: 89  QYKKALENETNERNLAHQELI---KQKKDISIQLSSAQSR-CTLLEKQLEYTKRMVLNVE 144
           Q  + ++ E +       +LI    + KD+   L +++S   TL   +L+    ++   E
Sbjct: 676 QKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 735

Query: 145 REKNMILE--QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEK 202
           +EK  + +  Q+ QL+ E  + QMK     EK + L+++  +L       +D+ K LE+ 
Sbjct: 736 KEKGTLEQEVQELQLKTELLEKQMK-----EKENDLQEKFAQLEAENSILKDEKKTLEDM 790

Query: 203 LK----EEEHQRKLFQD 215
           LK      + +R +F D
Sbjct: 791 LKIHTPVSQEERLIFLD 807



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 74/380 (19%), Positives = 150/380 (39%), Gaps = 65/380 (17%)

Query: 63   QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
            Q++I +LE ++ +       +S    +  + L N   E+     EL+  K+ +   +   
Sbjct: 2084 QQEIQKLE-QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142

Query: 123  QSRCTLLEKQLEYTKRMVL--------NVEREKNMILEQQAQLQRE----KEQDQMKLYA 170
                  LE ++   ++ +L         VE +  + LE Q Q +R+    KE++   L  
Sbjct: 2143 NEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE 2202

Query: 171  KLEKL-DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK- 228
            +LE+  + LE +   +       E + K    +L+E E + KLF+D   +L   ++ S  
Sbjct: 2203 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDA 2262

Query: 229  -------IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDP 281
                   ++    + +   KE +      +  K +   +I +       + EK    RD 
Sbjct: 2263 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV---IEEKNELIRDL 2319

Query: 282  HILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL------- 334
                     T+  CL          + +  + E+ I   + L+E++  +Q EL       
Sbjct: 2320 E--------TQIECLMSDQ------ECVKRNREEEI---EQLNEVIEKLQQELANIGQKT 2362

Query: 335  ----DQMSMEHQELLKQMKETESHSVCDDIECE--------LECLLKKMEIKGEQISK-- 380
                  +S E   L  Q+    +  +  + + E        ++ +LK+   K  Q+++  
Sbjct: 2363 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2422

Query: 381  --LKKHQDSVCKLQQKVQNS 398
              LK+ ++SV K+Q   +NS
Sbjct: 2423 FSLKRERESVEKIQSIPENS 2442



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 69/340 (20%), Positives = 147/340 (43%), Gaps = 48/340 (14%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKK----ALENETNERNLAHQE 107
            S  L  A++ L E I     +   A+     L RE+ + K+    +L+ +   R   H+E
Sbjct: 1847 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE 1906

Query: 108  LIKQKKDISIQLSSAQS-------RCTLLEKQLEYTKRMVLNVERE----KNMILEQQAQ 156
              + ++ ++++LS A+          TL E+Q++    ++  +E+E     N + E +A+
Sbjct: 1907 S-RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAE 1965

Query: 157  LQR-EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQD 215
             Q+ ++E++ +    +  K +    E   L  T+K  ++K++   +  K  +  +K  Q 
Sbjct: 1966 QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK--QV 2023

Query: 216  KASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKM 275
            KA E+    ++S+ I            + +  K T+ +  R   Q      AL    EKM
Sbjct: 2024 KALEIDVEEQVSRFI------------ELEQEKNTELMDLRQQNQ------ALEKQLEKM 2065

Query: 276  RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIP---PDSEKSISICDNLSELLMAMQD 332
            R+  D   + +       +   +  +     K +P   P SE      + L+  L    D
Sbjct: 2066 RKFLDEQAIDREHERDVFQ--QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD 2123

Query: 333  ELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKME 372
            +  ++ +  ++L + ++E       ++IE +LE  ++++E
Sbjct: 2124 KCSELLLSKEQLQRDIQERN-----EEIE-KLEFRVRELE 2157



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 48/201 (23%), Positives = 90/201 (44%), Gaps = 24/201 (11%)

Query: 62  LQEKIHRLELERTQAEDNLNILSREAAQYKKAL---ENETNERNLAHQELIKQKKDISIQ 118
           LQ +  +L+   T      +  + +  Q K+ +   + +  E++   ++  K+K+D ++Q
Sbjct: 238 LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQ 297

Query: 119 LSSAQSRCTLLE----KQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEK 174
           +S  Q +  + E    K++E + +  +   +EK  I+E+      E+E+  ++L  KL  
Sbjct: 298 ISFLQEKIKVYEMEQDKKVENSNKEEI---QEKETIIEELNTKIIEEEKKTLELKDKLTT 354

Query: 175 LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV 234
            D L  E  +    QK  E K   LE           L   K  E Q+  EI K +M +V
Sbjct: 355 ADKLLGE-LQEQIVQKNQEIKNMKLE-----------LTNSKQKERQSSEEI-KQLMGTV 401

Query: 235 SNLKHSKEKKKSSKKTKCIKR 255
             L+  +  K S  +T  ++R
Sbjct: 402 EELQ-KRNHKDSQFETDIVQR 421



 Score = 35.8 bits (81), Expect = 0.084
 Identities = 62/345 (17%), Positives = 138/345 (40%), Gaps = 38/345 (11%)

Query: 57  LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDIS 116
           +A+  L  K+     ++ + ++ L ++  E    ++ LE+   E + + +++ + ++ I+
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA 552

Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
            Q S        L    +    +V   E  K + L+ +A++   K            KL+
Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI-----------KLE 601

Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF--QDKASELQTGLEISKIIMSSV 234
           +LEKE       +    D++   +E   E    + LF  +++ S+L+  LEI   I    
Sbjct: 602 MLEKE-------KNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI---- 650

Query: 235 SNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
            N++  K+      K          QI      +    E M+  +D  I ++   + E  
Sbjct: 651 -NIEKLKDNLGIHYKQ---------QIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700

Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
            L    ++    K+     E ++ I +   E+ +  Q+E ++ ++E +    Q+K     
Sbjct: 701 KLKDLQQSLVNSKS----EEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756

Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSK 399
               + E +L+    ++E +   +   KK  + + K+   V   +
Sbjct: 757 KQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 43/212 (20%), Positives = 89/212 (41%), Gaps = 26/212 (12%)

Query: 58   ALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI 117
            ALK+L+ + +    E       +N+ +R        LE+  + ++L   +  KQ KD+  
Sbjct: 2465 ALKSLENQTYFKSFEENGKGSIINLETRLLQ-----LESTVSAKDLELTQCYKQIKDMQE 2519

Query: 118  QLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE-----QDQMKLYAKL 172
            Q    Q    +L+K++   +++V   E +    L  Q QL+  +E     QD   + ++ 
Sbjct: 2520 Q---GQFETEMLQKKIVNLQKIV---EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573

Query: 173  EKLDV----------LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT 222
            E+ ++          L  +   LT      E ++  +   L  E+ Q ++ +    E + 
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633

Query: 223  GLEISKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
             L   + ++      +  KEKK+S +  + +K
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 42/208 (20%), Positives = 104/208 (50%), Gaps = 19/208 (9%)

Query: 53   QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
            +A I  + +L++ I +++L+R +AE        +++Q  ++  +   E  LA Q++  ++
Sbjct: 2977 KAYINTISSLKDLITKMQLQR-EAE------VYDSSQSHESFSDWRGELLLALQQVFLEE 3029

Query: 113  KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
            +  S+ L++ ++  T L           L  +R +   +E QA ++  ++ D+  L +++
Sbjct: 3030 R--SVLLAAFRTELTALGTTDAVGLLNCLE-QRIQEQGVEYQAAMECLQKADRRSLLSEI 3086

Query: 173  EKLDV--------LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL 224
            + L          L++E      +Q+  E  I+  + ++ E + +    +D+A+ELQ  L
Sbjct: 3087 QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQL 3146

Query: 225  EISKIIMSSV-SNLKHSKEKKKSSKKTK 251
               K++++ + S L  +K + +++ K +
Sbjct: 3147 SSEKMVVAELKSELAQTKLELETTLKAQ 3174


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)

Query: 40   EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
            E++  K      ++ALIL  K   ++  + E E+ +  AE+   L++ ++EAA+ ++  E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
             +  ++    ++++K+K     + +  ++   LL++Q E  +     ++ +K  + +Q A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 156  Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
            +     QR  E   Q Q+++ A+ E+L +   E  R     +    + +   E++ E+ H
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 209  QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
            + +L  Q+K + +QT LEI        ++ +  +++ L+  KEK +   K   +K
Sbjct: 2419 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
            ++AL L L+  +E   +  L + +AE       REA +  KA E    +R LA QEL KQ
Sbjct: 1639 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 112  KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
            ++   +   +AQ R    E++L   +      E+++ ++ E+ A+LQRE     Q + +L
Sbjct: 1698 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
             A+L K   +  E   L  ++  AE++ +   EK K+  E +   F++ A E
Sbjct: 1754 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
            ++LQE+   +   R +AE        EA + ++  E E     L   E ++   Q ++++
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             Q S AQ+     EKQ E  +R      + +   + Q+   ++E E+ +       ++  
Sbjct: 1653 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
              E+E  RL    +  E + + LEE+L   + +      K  EL+  L   +  M  +  
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 235  SNLKHSKEKKKSSKKTK 251
            S  +  +E + +S+K+K
Sbjct: 1770 SKARAEEESRSTSEKSK 1786



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)

Query: 64   EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            EK+HR EL   E+      L I  +++    + L     E     ++L ++ K   +QL 
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2472

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
            S + +    E+ L+ T+ +  +   EK+ +L+++  +++EK   EQ      AK ++L  
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 176  ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
                    +E+E  RL  +       Q  AE+ ++  +E+L++ E QR+  ++  +E
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            L+E++ RL+ E   A      L  E A+ +  +E     +  A +E     +    +L +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
               R   L ++    + +    +R++ +  E  A+ + E E+   +  A + +   L+ E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851

Query: 182  CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
               +   +K AE+  + L    ++E  QR+  +++A++ +  +E  ++++  +S S L+ 
Sbjct: 1852 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908

Query: 240  SK 241
             K
Sbjct: 1909 QK 1910



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            + SQ    A +E+ S     +  ++    AL+ L+E    L L+  +AE  L     E A
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1560

Query: 89   -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
             Q + ALE  T +R+ A  EL  Q K  S    +AQ     LE+ L+     V  +  E 
Sbjct: 1561 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1610

Query: 148  NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
                +QQA+ +R +E+ +     +LE+  +   E  RL    ++ A+ K   +   EK K
Sbjct: 1611 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 205  EEEHQRKLFQDKASE 219
            EE  +    + KA E
Sbjct: 1667 EEAEREARRRGKAEE 1681



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            +Q+K   L+    Q +  L+ L  EA   ++A E     R  A +E  + ++    Q+  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2113

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
            A+      E+Q +   +     E+ +    EQ+A  + + EQ  ++     +      K+
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 182  CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
                T  QK   E ++  L  +L+E +HQ+ L  ++               S+++  L  
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 227  SKIIMSSVSNLK 238
             ++ M  +S LK
Sbjct: 2233 VRVQMEELSKLK 2244


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)

Query: 40   EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
            E++  K      ++ALIL  K   ++  + E E+ +  AE+   L++ ++EAA+ ++  E
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
             +  ++    ++++K+K     + +  ++   LL++Q E  +     ++ +K  + +Q A
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362

Query: 156  Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
            +     QR  E   Q Q+++ A+ E+L +   E  R     +    + +   E++ E+ H
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2422

Query: 209  QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
            + +L  Q+K + +QT LEI        ++ +  +++ L+  KEK +   K   +K
Sbjct: 2423 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
            ++AL L L+  +E   +  L + +AE       REA +  KA E    +R LA QEL KQ
Sbjct: 1643 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701

Query: 112  KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
            ++   +   +AQ R    E++L   +      E+++ ++ E+ A+LQRE     Q + +L
Sbjct: 1702 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
             A+L K   +  E   L  ++  AE++ +   EK K+  E +   F++ A E
Sbjct: 1758 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
            ++LQE+   +   R +AE        EA + ++  E E     L   E ++   Q ++++
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             Q S AQ+     EKQ E  +R      + +   + Q+   ++E E+ +       ++  
Sbjct: 1657 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
              E+E  RL    +  E + + LEE+L   + +      K  EL+  L   +  M  +  
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773

Query: 235  SNLKHSKEKKKSSKKTK 251
            S  +  +E + +S+K+K
Sbjct: 1774 SKARAEEESRSTSEKSK 1790



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)

Query: 64   EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            EK+HR EL   E+      L I  +++    + L     E     ++L ++ K   +QL 
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2476

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
            S + +    E+ L+ T+ +  +   EK+ +L+++  +++EK   EQ      AK ++L  
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536

Query: 176  ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
                    +E+E  RL  +       Q  AE+ ++  +E+L++ E QR+  ++  +E
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            L+E++ RL+ E   A      L  E A+ +  +E     +  A +E     +    +L +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
               R   L ++    + +    +R++ +  E  A+ + E E+   +  A + +   L+ E
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855

Query: 182  CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
               +   +K AE+  + L    ++E  QR+  +++A++ +  +E  ++++  +S S L+ 
Sbjct: 1856 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912

Query: 240  SK 241
             K
Sbjct: 1913 QK 1914



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            + SQ    A +E+ S     +  ++    AL+ L+E    L L+  +AE  L     E A
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1564

Query: 89   -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
             Q + ALE  T +R+ A  EL  Q K  S    +AQ     LE+ L+     V  +  E 
Sbjct: 1565 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1614

Query: 148  NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
                +QQA+ +R +E+ +     +LE+  +   E  RL    ++ A+ K   +   EK K
Sbjct: 1615 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670

Query: 205  EEEHQRKLFQDKASE 219
            EE  +    + KA E
Sbjct: 1671 EEAEREARRRGKAEE 1685



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            +Q+K   L+    Q +  L+ L  EA   ++A E     R  A +E  + ++    Q+  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2117

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
            A+      E+Q +   +     E+ +    EQ+A  + + EQ  ++     +      K+
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2176

Query: 182  CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
                T  QK   E ++  L  +L+E +HQ+ L  ++               S+++  L  
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236

Query: 227  SKIIMSSVSNLK 238
             ++ M  +S LK
Sbjct: 2237 VRVQMEELSKLK 2248


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)

Query: 40   EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
            E++  K      ++ALIL  K   ++  + E E+ +  AE+   L++ ++EAA+ ++  E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
             +  ++    ++++K+K     + +  ++   LL++Q E  +     ++ +K  + +Q A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 156  Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
            +     QR  E   Q Q+++ A+ E+L +   E  R     +    + +   E++ E+ H
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418

Query: 209  QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
            + +L  Q+K + +QT LEI        ++ +  +++ L+  KEK +   K   +K
Sbjct: 2419 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
            ++AL L L+  +E   +  L + +AE       REA +  KA E    +R LA QEL KQ
Sbjct: 1639 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697

Query: 112  KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
            ++   +   +AQ R    E++L   +      E+++ ++ E+ A+LQRE     Q + +L
Sbjct: 1698 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
             A+L K   +  E   L  ++  AE++ +   EK K+  E +   F++ A E
Sbjct: 1754 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
            ++LQE+   +   R +AE        EA + ++  E E     L   E ++   Q ++++
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             Q S AQ+     EKQ E  +R      + +   + Q+   ++E E+ +       ++  
Sbjct: 1653 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
              E+E  RL    +  E + + LEE+L   + +      K  EL+  L   +  M  +  
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 235  SNLKHSKEKKKSSKKTK 251
            S  +  +E + +S+K+K
Sbjct: 1770 SKARAEEESRSTSEKSK 1786



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)

Query: 64   EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            EK+HR EL   E+      L I  +++    + L     E     ++L ++ K   +QL 
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2472

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
            S + +    E+ L+ T+ +  +   EK+ +L+++  +++EK   EQ      AK ++L  
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 176  ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
                    +E+E  RL  +       Q  AE+ ++  +E+L++ E QR+  ++  +E
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            L+E++ RL+ E   A      L  E A+ +  +E     +  A +E     +    +L +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
               R   L ++    + +    +R++ +  E  A+ + E E+   +  A + +   L+ E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851

Query: 182  CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
               +   +K AE+  + L    ++E  QR+  +++A++ +  +E  ++++  +S S L+ 
Sbjct: 1852 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908

Query: 240  SK 241
             K
Sbjct: 1909 QK 1910



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            + SQ    A +E+ S     +  ++    AL+ L+E    L L+  +AE  L     E A
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1560

Query: 89   -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
             Q + ALE  T +R+ A  EL  Q K  S    +AQ     LE+ L+     V  +  E 
Sbjct: 1561 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1610

Query: 148  NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
                +QQA+ +R +E+ +     +LE+  +   E  RL    ++ A+ K   +   EK K
Sbjct: 1611 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666

Query: 205  EEEHQRKLFQDKASE 219
            EE  +    + KA E
Sbjct: 1667 EEAEREARRRGKAEE 1681



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            +Q+K   L+    Q +  L+ L  EA   ++A E     R  A +E  + ++    Q+  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2113

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
            A+      E+Q +   +     E+ +    EQ+A  + + EQ  ++     +      K+
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 182  CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
                T  QK   E ++  L  +L+E +HQ+ L  ++               S+++  L  
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 227  SKIIMSSVSNLK 238
             ++ M  +S LK
Sbjct: 2233 VRVQMEELSKLK 2244


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)

Query: 40   EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
            E++  K      ++ALIL  K   ++  + E E+ +  AE+   L++ ++EAA+ ++  E
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
             +  ++    ++++K+K     + +  ++   LL++Q E  +     ++ +K  + +Q A
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326

Query: 156  Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
            +     QR  E   Q Q+++ A+ E+L +   E  R     +    + +   E++ E+ H
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2386

Query: 209  QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
            + +L  Q+K + +QT LEI        ++ +  +++ L+  KEK +   K   +K
Sbjct: 2387 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
            ++AL L L+  +E   +  L + +AE       REA +  KA E    +R LA QEL KQ
Sbjct: 1607 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665

Query: 112  KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
            ++   +   +AQ R    E++L   +      E+++ ++ E+ A+LQRE     Q + +L
Sbjct: 1666 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
             A+L K   +  E   L  ++  AE++ +   EK K+  E +   F++ A E
Sbjct: 1722 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
            ++LQE+   +   R +AE        EA + ++  E E     L   E ++   Q ++++
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             Q S AQ+     EKQ E  +R      + +   + Q+   ++E E+ +       ++  
Sbjct: 1621 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
              E+E  RL    +  E + + LEE+L   + +      K  EL+  L   +  M  +  
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737

Query: 235  SNLKHSKEKKKSSKKTK 251
            S  +  +E + +S+K+K
Sbjct: 1738 SKARAEEESRSTSEKSK 1754



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)

Query: 64   EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            EK+HR EL   E+      L I  +++    + L     E     ++L ++ K   +QL 
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2440

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
            S + +    E+ L+ T+ +  +   EK+ +L+++  +++EK   EQ      AK ++L  
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500

Query: 176  ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
                    +E+E  RL  +       Q  AE+ ++  +E+L++ E QR+  ++  +E
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            L+E++ RL+ E   A      L  E A+ +  +E     +  A +E     +    +L +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
               R   L ++    + +    +R++ +  E  A+ + E E+   +  A + +   L+ E
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819

Query: 182  CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
               +   +K AE+  + L    ++E  QR+  +++A++ +  +E  ++++  +S S L+ 
Sbjct: 1820 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876

Query: 240  SK 241
             K
Sbjct: 1877 QK 1878



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            + SQ    A +E+ S     +  ++    AL+ L+E    L L+  +AE  L     E A
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1528

Query: 89   -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
             Q + ALE  T +R+ A  EL  Q K  S    +AQ     LE+ L+     V  +  E 
Sbjct: 1529 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1578

Query: 148  NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
                +QQA+ +R +E+ +     +LE+  +   E  RL    ++ A+ K   +   EK K
Sbjct: 1579 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634

Query: 205  EEEHQRKLFQDKASE 219
            EE  +    + KA E
Sbjct: 1635 EEAEREARRRGKAEE 1649



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            +Q+K   L+    Q +  L+ L  EA   ++A E     R  A +E  + ++    Q+  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2081

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
            A+      E+Q +   +     E+ +    EQ+A  + + EQ  ++     +      K+
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2140

Query: 182  CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
                T  QK   E ++  L  +L+E +HQ+ L  ++               S+++  L  
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200

Query: 227  SKIIMSSVSNLK 238
             ++ M  +S LK
Sbjct: 2201 VRVQMEELSKLK 2212


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)

Query: 40   EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
            E++  K      ++ALIL  K   ++  + E E+ +  AE+   L++ ++EAA+ ++  E
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435

Query: 96   NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
             +  ++    ++++K+K     + +  ++   LL++Q E  +     ++ +K  + +Q A
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495

Query: 156  Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
            +     QR  E   Q Q+++ A+ E+L +   E  R     +    + +   E++ E+ H
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2555

Query: 209  QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
            + +L  Q+K + +QT LEI        ++ +  +++ L+  KEK +   K   +K
Sbjct: 2556 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 52   SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
            ++AL L L+  +E   +  L + +AE       REA +  KA E    +R LA QEL KQ
Sbjct: 1776 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834

Query: 112  KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
            ++   +   +AQ R    E++L   +      E+++ ++ E+ A+LQRE     Q + +L
Sbjct: 1835 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890

Query: 169  YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
             A+L K   +  E   L  ++  AE++ +   EK K+  E +   F++ A E
Sbjct: 1891 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)

Query: 60   KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
            ++LQE+   +   R +AE        EA + ++  E E     L   E ++   Q ++++
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789

Query: 117  IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
             Q S AQ+     EKQ E  +R      + +   + Q+   ++E E+ +       ++  
Sbjct: 1790 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846

Query: 177  VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
              E+E  RL    +  E + + LEE+L   + +      K  EL+  L   +  M  +  
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906

Query: 235  SNLKHSKEKKKSSKKTK 251
            S  +  +E + +S+K+K
Sbjct: 1907 SKARAEEESRSTSEKSK 1923



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)

Query: 64   EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
            EK+HR EL   E+      L I  +++    + L     E     ++L ++ K   +QL 
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2609

Query: 121  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
            S + +    E+ L+ T+ +  +   EK+ +L+++  +++EK   EQ      AK ++L  
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669

Query: 176  ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
                    +E+E  RL  +       Q  AE+ ++  +E+L++ E QR+  ++  +E
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            L+E++ RL+ E   A      L  E A+ +  +E     +  A +E     +    +L +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
               R   L ++    + +    +R++ +  E  A+ + E E+   +  A + +   L+ E
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988

Query: 182  CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
               +   +K AE+  + L    ++E  QR+  +++A++ +  +E  ++++  +S S L+ 
Sbjct: 1989 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045

Query: 240  SK 241
             K
Sbjct: 2046 QK 2047



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 29   EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
            + SQ    A +E+ S     +  ++    AL+ L+E    L L+  +AE  L     E A
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1697

Query: 89   -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
             Q + ALE  T +R+ A  EL  Q K  S    +AQ     LE+ L+     V  +  E 
Sbjct: 1698 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1747

Query: 148  NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
                +QQA+ +R +E+ +     +LE+  +   E  RL    ++ A+ K   +   EK K
Sbjct: 1748 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803

Query: 205  EEEHQRKLFQDKASE 219
            EE  +    + KA E
Sbjct: 1804 EEAEREARRRGKAEE 1818



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)

Query: 62   LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
            +Q+K   L+    Q +  L+ L  EA   ++A E     R  A +E  + ++    Q+  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2250

Query: 122  AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
            A+      E+Q +   +     E+ +    EQ+A  + + EQ  ++     +      K+
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2309

Query: 182  CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
                T  QK   E ++  L  +L+E +HQ+ L  ++               S+++  L  
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369

Query: 227  SKIIMSSVSNLK 238
             ++ M  +S LK
Sbjct: 2370 VRVQMEELSKLK 2381


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.126    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,590,059
Number of Sequences: 37866
Number of extensions: 818501
Number of successful extensions: 8526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 748
Number of HSP's that attempted gapping in prelim test: 4320
Number of HSP's gapped (non-prelim): 3165
length of query: 460
length of database: 18,247,518
effective HSP length: 106
effective length of query: 354
effective length of database: 14,233,722
effective search space: 5038737588
effective search space used: 5038737588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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