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Search of human proteins with 55770852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55770852 glutamate receptor, ionotropic, delta 1 precursor
[Homo sapiens]
(1009 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 2017 0.0
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 1169 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 375 e-104
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 373 e-103
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 362 1e-99
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 360 4e-99
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 358 1e-98
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 350 5e-96
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 350 5e-96
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 343 4e-94
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 341 2e-93
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 340 3e-93
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 332 8e-91
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 332 1e-90
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 327 3e-89
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 327 3e-89
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 298 2e-80
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 297 4e-80
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 203 6e-52
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 202 2e-51
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 202 2e-51
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 164 4e-40
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 162 1e-39
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 162 1e-39
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 162 1e-39
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 162 1e-39
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 149 2e-35
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 140 5e-33
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 135 1e-31
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 69 2e-11
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 2017 bits (5225), Expect = 0.0
Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)
Query: 1 MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKI 60
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKI
Sbjct: 1 MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKI 60
Query: 61 TYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNP 120
TYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNP
Sbjct: 61 TYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNP 120
Query: 121 GGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS 180
GGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
Sbjct: 121 GGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS 180
Query: 181 FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI 240
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI
Sbjct: 181 FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI 240
Query: 241 NEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHR 300
NEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHR
Sbjct: 241 NEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHR 300
Query: 301 ISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWN 360
ISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWN
Sbjct: 301 ISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWN 360
Query: 361 GGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKG 420
GGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKG
Sbjct: 361 GGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKG 420
Query: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGF 480
LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGF
Sbjct: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGF 480
Query: 481 KYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS 540
KYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS
Sbjct: 481 KYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS 540
Query: 541 VGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPS 600
VGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPS
Sbjct: 541 VGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPS 600
Query: 601 ASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
ASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR
Sbjct: 601 ASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
Query: 661 MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN 720
MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN
Sbjct: 661 MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN 720
Query: 721 CVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPY 780
CVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPY
Sbjct: 721 CVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPY 780
Query: 781 RDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAI 840
RDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAI
Sbjct: 781 RDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAI 840
Query: 841 GLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIEL 900
GLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIEL
Sbjct: 841 GLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIEL 900
Query: 901 SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT 960
SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT
Sbjct: 901 SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT 960
Query: 961 MPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI 1009
MPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
Sbjct: 961 MPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI 1009
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 1169 bits (3024), Expect = 0.0
Identities = 568/1010 (56%), Positives = 762/1010 (75%), Gaps = 16/1010 (1%)
Query: 4 LTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYS 63
L++W W S ADSIIHIGAIF+E+A KDD VF+ AV DL+ N++ILQ+EKIT+S
Sbjct: 10 LSVW---WSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFS 66
Query: 64 IKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGS 123
+ ++ NNPFQAVQEAC+LM QGILALV+S GC SA +LQSL DAMHIPHLF+QR+ G+
Sbjct: 67 VTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGT 126
Query: 124 PRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLD 183
PR+ C L S + YTL+ RPPV L+DV+LR+VTE WQKF++FYDSEYDIRG+Q FLD
Sbjct: 127 PRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD 186
Query: 184 QASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEA 243
+ S+ G+DV+LQKV+ NI+ + T+LF TM+ EELNRYRDTLRRAIL+++P A SFI E
Sbjct: 187 KVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEV 246
Query: 244 VETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKD-NQKCTRNNHRIS 302
VETNL + D HW+ +NEEI+D ++ +LV ++GR+T++RQ FP ++ +Q+C R NHRIS
Sbjct: 247 VETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRIS 306
Query: 303 SLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGG 362
S LCDP++ + Q ++ISNLY+YD+VL+LANAFH+KLEDRKWHSMASL+CIRK++KPW GG
Sbjct: 307 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366
Query: 363 RSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLN 422
RSML+TIKKG ++GLTG +EF E+ NP V FEILGT Y E G+ +RKL W+ GLN
Sbjct: 367 RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426
Query: 423 GSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKY 482
GSL ++ + + ++G+ L+VVTVLEEPFVMV+EN+LG+PK+Y+GFSIDVLDAL+ LGF Y
Sbjct: 427 GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNY 486
Query: 483 EIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVG 542
EIY APD +YG + +WNG++GEL+ KRAD+ ISA+TITP+RE+VVDF+ RYMDYSVG
Sbjct: 487 EIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVG 546
Query: 543 ILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSAS 602
+L+++ E+ + +F+ APFD ++WACIA + +VG+L+++LN + R Q + S
Sbjct: 547 VLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM----TS 602
Query: 603 ATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMD 662
TL++++W VYG+FVQQGGE ++A R++MG+WWLF LIV SSYTANLAAFLT++R++
Sbjct: 603 TTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
Query: 663 NPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCV 722
+ I++ QDLSKQ E+ YGTV DSAVYE+ R KG NP E+DS ++++WR I+++ G++N V
Sbjct: 663 SSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNV 722
Query: 723 SSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRD 782
GI+K K GNYAF+WD AV+EY A+ D DCS IGN+++ +GYGIALQHGSPYRD
Sbjct: 723 LESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRD 782
Query: 783 LFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGL 842
+FSQRILELQ GD+D+LK KWWP G+CDL S + G +L + SFAGVFCILA G+
Sbjct: 783 VFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGI 842
Query: 843 LLACLVAALELWWNSNRCHQETPKE-DKEVNLEQVHRRMNSL-MDEDIAHKQISPASIEL 900
+L+C +A LE WWN + + KE DKE++LE +HRR+NSL D+D HKQ S +SI+L
Sbjct: 843 VLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDL 902
Query: 901 SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPL-PLSSSA 959
+ L++ L Q LE +++NT ++ +TF+PEQ SRTLS+ +S +
Sbjct: 903 TPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQ-IQTLSRTLSAKAASGFTFGNVPEHR 961
Query: 960 TMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI 1009
T P +HR+PNGG FR SP+KT + +QP P L D GTSI
Sbjct: 962 TGP---FRHRAPNGGFFR-SPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI 1007
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 375 bits (964), Expect = e-104
Identities = 273/896 (30%), Positives = 438/896 (48%), Gaps = 90/896 (10%)
Query: 5 TLW-LLPWICQCVSVRADSIIHIGAIFE----ENAAKDDRVFQLAVSDLSLNDDILQSEK 59
T W LL ++C + A ++ IG IFE E ++ F+ AV+ ++ N ++ +
Sbjct: 17 TSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTT 76
Query: 60 ITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-R 118
+TY I+ I + F+A + ACD + G+ AL + +S +A+QS+ +A+ +PH+ + +
Sbjct: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWK 136
Query: 119 NPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL 178
+P + ++N PD Y SR +L LV W+ + Y+ + L
Sbjct: 137 HPSVDNKDLFYINLYPD---YAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRL 186
Query: 179 QSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHS 238
Q + SR + + ++++ L K +E I S + A
Sbjct: 187 QELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFY--------VIFDCSHETAAE 238
Query: 239 FINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNN 298
+ + + + ++ H+ F ++ + L+L + MT R + +N
Sbjct: 239 ILKQILFMGMMTEYYHYFFTTLDLFALD-LELYRYSGVNMTGFRLL----------NIDN 287
Query: 299 HRISSLLCD-----------PQEGYLQ-MLQISNLYLYDSVLMLANAFHRKLEDRKWHSM 346
+SS++ P+ G L M+ +YD+V M+A A HR + ++
Sbjct: 288 PHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQ----LTV 343
Query: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEF------REDSSNPYVQFEILGTT 400
+SL C R KPW G ++ IK+ GLTG + F R+D + + GT
Sbjct: 344 SSLQCHRH--KPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTE 401
Query: 401 -----YSETFGKDMRKLATWDSEKGLNGSLQERPMGSR----LQGLTLKVVTVLEEPFVM 451
S+ K +K+ W+S GLN + + S L TL V T+LEEP+VM
Sbjct: 402 KAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVM 461
Query: 452 V--AENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELI 509
++ L R++G+ +D+L L+ LGF Y++ PDG+YG Q WNGM+ ELI
Sbjct: 462 YRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELI 521
Query: 510 SKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE-EKISIFSLFAPFDFAVWAC 568
RADLA++ +TIT RE V+DFSK +M + IL +KP +FS P +W
Sbjct: 522 DHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMY 581
Query: 569 IAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA-----TLHSAIWIVYGAFVQQGGES 623
+ A V ++FV+ R + P + TL ++ W GA +QQG E
Sbjct: 582 VLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 641
Query: 624 SVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVR 683
+++ RIV G WW FTLI+ SSYTANLAAFLTV RM++PI + DL+KQ ++ YG VR
Sbjct: 642 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVR 701
Query: 684 DSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDV 743
D + +F+ + ST+ ++W +S V + EGI++ +YA L +
Sbjct: 702 DGSTMTFFKK------SKISTYEKMWAFMSSR-QQTALVRNSDEGIQRVLTTDYALLMES 754
Query: 744 AVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQK 803
+EY +T +C++T IG I SKGYG+ GSPYRD + IL+LQ+ G L ++K+K
Sbjct: 755 TSIEY--VTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 812
Query: 804 WWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNR 859
WW G C + A A L + + G+F +LA GL+L+ VA E + S +
Sbjct: 813 WWRGNG-CPEEDNKEASA----LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 863
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 373 bits (958), Expect = e-103
Identities = 271/891 (30%), Positives = 434/891 (48%), Gaps = 95/891 (10%)
Query: 5 TLW-LLPWICQCVSVRADSIIHIGAIFE----ENAAKDDRVFQLAVSDLSLNDDILQSEK 59
T W LL ++C + A ++ IG IFE E ++ F+ AV+ ++ N ++ +
Sbjct: 17 TSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTT 76
Query: 60 ITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-R 118
+TY I+ I + F+A + ACD + G+ AL + +S +A+QS+ +A+ +PH+ + +
Sbjct: 77 LTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWK 136
Query: 119 NPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL 178
+P + ++N PD Y SR +L LV W+ + Y+ + L
Sbjct: 137 HPSVDNKDLFYINLYPD---YAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRL 186
Query: 179 QSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHS 238
Q + SR + + ++++ L K +E I S + A
Sbjct: 187 QELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFY--------VIFDCSHETAAE 238
Query: 239 FINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNN 298
+ + + + ++ H+ F ++ + L+L + MT R + +N
Sbjct: 239 ILKQILFMGMMTEYYHYFFTTLDLFALD-LELYRYSGVNMTGFRLL----------NIDN 287
Query: 299 HRISSLLCD-----------PQEGYLQ-MLQISNLYLYDSVLMLANAFHRKLEDRKWHSM 346
+SS++ P+ G L M+ +YD+V M+A A HR + ++
Sbjct: 288 PHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQ----LTV 343
Query: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEF------REDSSNPYVQFEILGTT 400
+SL C R KPW G ++ IK+ GLTG + F R+D + + GT
Sbjct: 344 SSLQCHRH--KPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGT- 400
Query: 401 YSETFGKDMRKLATWDSEKGLNGSLQERPMGSR----LQGLTLKVVTVLEEPFVMV--AE 454
K+ W+S GLN + + S L TL V T+LEEP+VM ++
Sbjct: 401 ---------EKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 451
Query: 455 NILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRAD 514
L R++G+ +D+L L+ LGF Y++ PDG+YG Q WNGM+ ELI RAD
Sbjct: 452 KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRAD 511
Query: 515 LAISAITITPERESVVDFSKRYMDYSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAI 573
LA++ +TIT RE V+DFSK +M + IL +KP +FS P +W + A
Sbjct: 512 LAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLAC 571
Query: 574 PVVGVLIFVLNRIQAVRAQSAAQPRPSASA-----TLHSAIWIVYGAFVQQGGESSVNSM 628
V ++FV+ R + P + TL ++ W GA +QQG E ++
Sbjct: 572 LGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKAL 631
Query: 629 AMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVY 688
+ RIV G WW FTLI+ SSYTANLAAFLTV RM++PI + DL+KQ ++ YG VRD +
Sbjct: 632 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTM 691
Query: 689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEY 748
+F+ + ST+ ++W +S V + EGI++ +YA L + +EY
Sbjct: 692 TFFKK------SKISTYEKMWAFMSSR-QQTALVRNSDEGIQRVLTTDYALLMESTSIEY 744
Query: 749 AALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHM 808
+T +C++T IG I SKGYG+ GSPYRD + IL+LQ+ G L ++K+KWW
Sbjct: 745 --VTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN 802
Query: 809 GRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNR 859
G C + A A L + + G+F +LA GL+L+ VA E + S +
Sbjct: 803 G-CPEEDNKEASA----LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRK 848
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 362 bits (928), Expect = 1e-99
Identities = 264/907 (29%), Positives = 447/907 (49%), Gaps = 85/907 (9%)
Query: 23 IIHIGAIFEENAA----KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE 78
++ G IFE + ++ F+ AV+ ++ N +L + +TY + I + F+A ++
Sbjct: 35 VLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKK 94
Query: 79 ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSPDGE 137
ACD ++ G+ A+ + +SANA+QS+ +A+ +PH+ + ++ + + +++ PD
Sbjct: 95 ACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFS 154
Query: 138 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197
+ L+ +L LV +W+ + YD + LQ + SR L + ++++
Sbjct: 155 S----------LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQL 204
Query: 198 DKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVF 257
+ L + +E + I S + A + +A+ + ++ H++F
Sbjct: 205 PADTKDAKPLLKEMKRGKEFH--------VIFDCSHEMAAGILKQALAMGMMTEYYHYIF 256
Query: 258 VNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----------C 306
++ ++ +S + MT R + N ++SS++
Sbjct: 257 TTLDLFALDVEPYRYSGVN-MTGFRIL----------NTENTQVSSIIEKWSMERLQAPP 305
Query: 307 DPQEGYLQMLQISNLYL-YDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSM 365
P G L ++ L YD+V +++ A ++ +++SL C R KPW G
Sbjct: 306 KPDSGLLDGFMTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFGTRF 359
Query: 366 LDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSL 425
+ IK+ H GLTG + F + ++ F++ + E + + K+ TWD GLN +
Sbjct: 360 MSLIKEAHWEGLTGRITFNK-TNGLRTDFDLDVISLKE---EGLEKIGTWDPASGLNMTE 415
Query: 426 QERPMGSR----LQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALG 479
++ + L +L V T+LEEP+V+ ++ L R++G+ ID+L L+ LG
Sbjct: 416 SQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILG 475
Query: 480 FKYEIYQAPDGRYGHQLH-NTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMD 538
F YEI DG+YG Q N WNGM+ ELI +ADLA++ + IT RE V+DFSK +M
Sbjct: 476 FTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT 535
Query: 539 YSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQP 597
+ IL +KP +FS P +W I A V ++FV+ R +
Sbjct: 536 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC 595
Query: 598 RPSASA-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652
P + TL ++ W GA +QQG E +++ RIV G WW FTLI+ SSYTANL
Sbjct: 596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 655
Query: 653 AAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTI 712
AAFLTV RM++PI + DL+KQ ++ YG V D A +F+ + ST+ ++W +
Sbjct: 656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKK------SKISTYDKMWAFM 709
Query: 713 SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGI 772
S V S EGI++ +YAFL + +E+ +T +C++T IG I SKGYG+
Sbjct: 710 SSR-RQSVLVKSNEEGIQRVLTSDYAFLMESTTIEF--VTQRNCNLTQIGGLIDSKGYGV 766
Query: 773 ALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFA 832
GSPYRD + IL+LQ+ G L ++K+KWW G C A A L + +
Sbjct: 767 GTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEASA----LGVQNIG 821
Query: 833 GVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQ 892
G+F +LA GL+L+ VA E + S + Q + +E++ RM+ + HK
Sbjct: 822 GIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEEL--RMSLKCQRRLKHKP 879
Query: 893 ISPASIE 899
+P ++
Sbjct: 880 QAPVIVK 886
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 360 bits (924), Expect = 4e-99
Identities = 269/906 (29%), Positives = 445/906 (49%), Gaps = 74/906 (8%)
Query: 23 IIHIGAIFE----ENAA---KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQA 75
+I IG IFE NA ++ F+ + + ++ N +L + +TY I+ I ++ F+A
Sbjct: 35 VIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEA 94
Query: 76 VQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSP 134
++ACD + G++A+ + + NA+QS+ +A+ +PH+ ++ ++ + ++N P
Sbjct: 95 TKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYP 154
Query: 135 DGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSL 194
D + L+ +L LV L+W+ + YD + LQ + SR + + +
Sbjct: 155 DYAS----------LSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKI 204
Query: 195 QK--VDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKD 252
++ +D + S +E+ R R+ R I S A + +A+ + ++
Sbjct: 205 RQLPIDSDDSRPL--------LKEMKRGREF--RIIFDCSHTMAAQILKQAMAMGMMTEY 254
Query: 253 SHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDP--QE 310
H++F ++ ++ +S + +T R I + + L P +
Sbjct: 255 YHFIFTTLDLYALDLEPYRYSGV-NLTGFR-ILNVDNPHVSAIVEKWSMERLQAAPRSES 312
Query: 311 GYLQMLQISN-LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTI 369
G L + +++ LYD+V +++ + R + ++ SL C R K W G ++ I
Sbjct: 313 GLLDGVMMTDAALLYDAVHIVSVCYQRAPQ----MTVNSLQCHRH--KAWRFGGRFMNFI 366
Query: 370 KKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERP 429
K+ GLTG + F + +S F++ + E + K+ W GLN + +
Sbjct: 367 KEAQWEGLTGRIVFNK-TSGLRTDFDLDIISLKE---DGLEKVGVWSPADGLNITEVAKG 422
Query: 430 MG----SRLQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALGFKYE 483
G L +L V TVLEEPFVM ++ L R++G+ ID+L LA LGF YE
Sbjct: 423 RGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYE 482
Query: 484 IYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGI 543
I DG+YG Q WNGM+ ELI +ADLA++ +TIT RE +DFSK +M V I
Sbjct: 483 IRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542
Query: 544 LIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSAS 602
L +KP S+FS P +W + A V ++FV+ R A P +
Sbjct: 543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSE 602
Query: 603 A-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLT 657
TL ++ W G+ +QQG E +++ RI+ G WW FTLI+ SSYTANLAAFLT
Sbjct: 603 VVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLT 662
Query: 658 VSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGG 717
V RM++PI + DL+KQ ++ YG V+D A +F+ + STF ++W +S
Sbjct: 663 VERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKK------SKISTFEKMWAFMSSKPS 716
Query: 718 ADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHG 777
A V + EGI++A +YA L + +EY +T +C++T IG I SKGYGI G
Sbjct: 717 A--LVKNNEEGIQRALTADYALLMESTTIEY--VTQRNCNLTQIGGLIDSKGYGIGTPMG 772
Query: 778 SPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCI 837
SPYRD + IL+LQ+ L ++K+KWW G C + A A L + G+F +
Sbjct: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSG-CPEEENKEASA----LGIQKIGGIFIV 827
Query: 838 LAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPAS 897
LA GL+L+ LVA E + + + + +++ R + + HK P
Sbjct: 828 LAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEI--RFSLTCQRRVKHKPQPPMM 885
Query: 898 IELSAL 903
++ A+
Sbjct: 886 VKTDAV 891
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 358 bits (919), Expect = 1e-98
Identities = 257/867 (29%), Positives = 431/867 (49%), Gaps = 83/867 (9%)
Query: 23 IIHIGAIFEENAA----KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE 78
++ G IFE + ++ F+ AV+ ++ N +L + +TY + I + F+A ++
Sbjct: 35 VLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKK 94
Query: 79 ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSPDGE 137
ACD ++ G+ A+ + +SANA+QS+ +A+ +PH+ + ++ + + +++ PD
Sbjct: 95 ACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFS 154
Query: 138 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197
+ L+ +L LV +W+ + YD + LQ + SR L + ++++
Sbjct: 155 S----------LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQL 204
Query: 198 DKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVF 257
+ L + +E + I S + A + +A+ + ++ H++F
Sbjct: 205 PADTKDAKPLLKEMKRGKEFH--------VIFDCSHEMAAGILKQALAMGMMTEYYHYIF 256
Query: 258 VNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----------C 306
++ ++ +S + MT R + N ++SS++
Sbjct: 257 TTLDLFALDVEPYRYSGVN-MTGFRIL----------NTENTQVSSIIEKWSMERLQAPP 305
Query: 307 DPQEGYLQMLQISNLYL-YDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSM 365
P G L ++ L YD+V +++ A ++ +++SL C R KPW G
Sbjct: 306 KPDSGLLDGFMTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFGTRF 359
Query: 366 LDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSL 425
+ IK+ H GLTG + F + ++ F++ + E + + K+ TWD GLN +
Sbjct: 360 MSLIKEAHWEGLTGRITFNK-TNGLRTDFDLDVISLKE---EGLEKIGTWDPASGLNMTE 415
Query: 426 QERPMGSR----LQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALG 479
++ + L +L V T+LEEP+V+ ++ L R++G+ ID+L L+ LG
Sbjct: 416 SQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILG 475
Query: 480 FKYEIYQAPDGRYGHQLH-NTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMD 538
F YEI DG+YG Q N WNGM+ ELI +ADLA++ + IT RE V+DFSK +M
Sbjct: 476 FTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT 535
Query: 539 YSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQP 597
+ IL +KP +FS P +W I A V ++FV+ R +
Sbjct: 536 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC 595
Query: 598 RPSASA-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652
P + TL ++ W GA +QQG E +++ RIV G WW FTLI+ SSYTANL
Sbjct: 596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 655
Query: 653 AAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTI 712
AAFLTV RM++PI + DL+KQ ++ YG V D A +F+ + ST+ ++W +
Sbjct: 656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKK------SKISTYDKMWAFM 709
Query: 713 SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGI 772
S V S EGI++ +YAFL + +E+ +T +C++T IG I SKGYG+
Sbjct: 710 SSR-RQSVLVKSNEEGIQRVLTSDYAFLMESTTIEF--VTQRNCNLTQIGGLIDSKGYGV 766
Query: 773 ALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFA 832
GSPYRD + IL+LQ+ G L ++K+KWW G C A A L + +
Sbjct: 767 GTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEASA----LGVQNIG 821
Query: 833 GVFCILAIGLLLACLVAALELWWNSNR 859
G+F +LA GL+L+ VA E + S +
Sbjct: 822 GIFIVLAAGLVLSVFVAVGEFLYKSKK 848
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 350 bits (897), Expect = 5e-96
Identities = 255/859 (29%), Positives = 421/859 (49%), Gaps = 71/859 (8%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLM 83
I IG +F A ++ F++ + S ++ ++T I +E N F C
Sbjct: 27 IQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAFCSQF 81
Query: 84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLAS 143
++G+ A+ S N + S +H+ + +P P+ + +
Sbjct: 82 SRGVYAIFGFYDKKSVNTITSFCGTLHVSFI--------TPSF-----PTDGTHPFVIQM 128
Query: 144 RPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISH 203
RP L +L L+ +W KF YDS+ + LQ+ LD A+ V+ V NI++
Sbjct: 129 RPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NINN 185
Query: 204 -----VFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFV 258
++ SLF ++ ++ RR IL + +++ + K H++
Sbjct: 186 DKKDEMYRSLFQDLELKKE-------RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIA 238
Query: 259 NEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEG-YLQMLQ 317
N +D ++L + G QI D+ ++ R S+L G + ++
Sbjct: 239 NLGFTDGDLLKIQFG--GANVSGFQIVDY--DDSLVSKFIERWSTLEEKEYPGAHTTTIK 294
Query: 318 ISNLYLYDSVLMLANAFHRKLEDRKWHSMASL--NCIRKSTKPWNGGRSMLDTIKKGHIT 375
++ YD+V ++ AF + R S +C+ PW G + +K+ +
Sbjct: 295 YTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVE 354
Query: 376 GLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQ 435
GL+G ++F ++ I+ E RK+ W + +L E P G+
Sbjct: 355 GLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS 409
Query: 436 GL---TLKVVTVLEEPFVMVAEN--ILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDG 490
GL T+ V T+LE P+VM+ +N +L +RY+G+ +D+ +AK GFKY++ DG
Sbjct: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469
Query: 491 RYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE 549
+YG + +T WNGM+GEL+ +AD+AI+ +TIT RE V+DFSK +M + I+IKKP+
Sbjct: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529
Query: 550 E-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR-----AQSAAQPRPSASA 603
+ K +FS P + +W CI A V V++F+++R + + + S S
Sbjct: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSEST 589
Query: 604 T---LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
+ +++W GAF++QG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV R
Sbjct: 590 NEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 649
Query: 661 MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN 720
M +PI + +DLSKQ E++YGT+ + E+FR + + F ++W T ++
Sbjct: 650 MVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRR------SKIAVFDKMW-TYMRSAEPSV 702
Query: 721 CVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGS 778
V + +EG+ + + KG YA+L + + EY C +G ++ SKGYGIA GS
Sbjct: 703 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPKGS 761
Query: 779 PYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCIL 838
R+ + +L+L + G LD LK KWW G C + ++ +L L + AGVF IL
Sbjct: 762 SLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKEKTSALSLSNVAGVFYIL 820
Query: 839 AIGLLLACLVAALELWWNS 857
GL LA LVA +E + S
Sbjct: 821 VGGLGLAMLVALIEFCYKS 839
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 350 bits (897), Expect = 5e-96
Identities = 256/859 (29%), Positives = 419/859 (48%), Gaps = 71/859 (8%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLM 83
I IG +F A ++ F++ + S ++ ++T I +E N F C
Sbjct: 27 IQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAFCSQF 81
Query: 84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLAS 143
++G+ A+ S N + S +H+ + +P P+ + +
Sbjct: 82 SRGVYAIFGFYDKKSVNTITSFCGTLHVSFI--------TPSF-----PTDGTHPFVIQM 128
Query: 144 RPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISH 203
RP L +L L+ +W KF YDS+ + LQ+ LD A+ V+ V NI++
Sbjct: 129 RPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NINN 185
Query: 204 -----VFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFV 258
++ SLF ++ ++ RR IL + +++ + K H++
Sbjct: 186 DKKDEMYRSLFQDLELKKE-------RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIA 238
Query: 259 NEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEG-YLQMLQ 317
N +D ++L + G QI D+ ++ R S+L G + ++
Sbjct: 239 NLGFTDGDLLKIQFG--GANVSGFQIVDY--DDSLVSKFIERWSTLEEKEYPGAHTTTIK 294
Query: 318 ISNLYLYDSVLMLANAFHRKLEDRKWHSMASL--NCIRKSTKPWNGGRSMLDTIKKGHIT 375
++ YD+V ++ AF + R S +C+ PW G + +K+ +
Sbjct: 295 YTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVE 354
Query: 376 GLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQ 435
GL+G ++F ++ I+ E RK+ W + +L E P G+
Sbjct: 355 GLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS 409
Query: 436 GL---TLKVVTVLEEPFVMVAEN--ILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDG 490
GL T+ V T+LE P+VM+ +N +L +RY+G+ +D+ +AK GFKY++ DG
Sbjct: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469
Query: 491 RYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE 549
+YG + +T WNGM+GEL+ +AD+AI+ +TIT RE V+DFSK +M + I+IKKP+
Sbjct: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529
Query: 550 E-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR-----AQSAAQPRPSASA 603
+ K +FS P + +W CI A V V++F+++R + + + S S
Sbjct: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSEST 589
Query: 604 T---LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
+ +++W GAF++QG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV R
Sbjct: 590 NEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 649
Query: 661 MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN 720
M +PI + +DLSKQ E++YGT+ + E+FR + + F ++W T ++
Sbjct: 650 MVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRR------SKIAVFDKMW-TYMRSAEPSV 702
Query: 721 CVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGS 778
V + +EG+ + + KG YA+L + + EY C +G ++ SKGYGIA GS
Sbjct: 703 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPKGS 761
Query: 779 PYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCIL 838
R + +L+L + G LD LK KWW G C S + +L L + AGVF IL
Sbjct: 762 SLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKT-SALSLSNVAGVFYIL 820
Query: 839 AIGLLLACLVAALELWWNS 857
GL LA LVA +E + S
Sbjct: 821 VGGLGLAMLVALIEFCYKS 839
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 343 bits (881), Expect = 4e-94
Identities = 249/824 (30%), Positives = 404/824 (49%), Gaps = 66/824 (8%)
Query: 59 KITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQR 118
++T I +E N F C ++G+ A+ S N + S +H+ +
Sbjct: 10 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFI---- 65
Query: 119 NPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL 178
+P P+ + + RP L +L L+ +W KF YDS+ + L
Sbjct: 66 ----TPSF-----PTDGTHPFVIQMRPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTL 114
Query: 179 QSFLDQASRLGLDVSLQKVDKNISH-----VFTSLFTTMKTEELNRYRDTLRRAILLLSP 233
Q+ LD A+ V+ V NI++ ++ SLF ++ ++ RR IL
Sbjct: 115 QAVLDSAAEKKWQVTAINVG-NINNDKKDEMYRSLFQDLELKKE-------RRVILDCER 166
Query: 234 QGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQK 293
+ +++ + K H++ N +D ++L + G QI D+
Sbjct: 167 DKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFG--GANVSGFQIVDY--DDSL 222
Query: 294 CTRNNHRISSLLCDPQEG-YLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASL--N 350
++ R S+L G + ++ ++ YD+V ++ AF + R S +
Sbjct: 223 VSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGD 282
Query: 351 CIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMR 410
C+ PW G + +K+ + GL+G ++F ++ I+ E R
Sbjct: 283 CLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIM-----ELKTNGPR 337
Query: 411 KLATWDSEKGLNGSLQERPMGSRLQGL---TLKVVTVLEEPFVMVAEN--ILGQPKRYKG 465
K+ W + +L E P G+ GL T+ V T+LE P+VM+ +N +L +RY+G
Sbjct: 338 KIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEG 397
Query: 466 FSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTS-WNGMIGELISKRADLAISAITITP 524
+ +D+ +AK GFKY++ DG+YG + +T WNGM+GEL+ +AD+AI+ +TIT
Sbjct: 398 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 457
Query: 525 ERESVVDFSKRYMDYSVGILIKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVL 583
RE V+DFSK +M + I+IKKP++ K +FS P + +W CI A V V++F++
Sbjct: 458 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 517
Query: 584 NRIQAVR-----AQSAAQPRPSASAT---LHSAIWIVYGAFVQQGGESSVNSMAMRIVMG 635
+R + + + S S + +++W GAF++QG + S S++ RIV G
Sbjct: 518 SRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGG 577
Query: 636 SWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKG 695
WW FTLI+ SSYTANLAAFLTV RM +PI + +DLSKQ E++YGT+ + E+FR
Sbjct: 578 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRR-- 635
Query: 696 TNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTD 753
+ + F ++W T ++ V + +EG+ + + KG YA+L + + EY
Sbjct: 636 ----SKIAVFDKMW-TYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE-QR 689
Query: 754 DDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDL 813
C +G ++ SKGYGIA GS R + +L+L + G LD LK KWW G C
Sbjct: 690 KPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA 749
Query: 814 TSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNS 857
S + +L L + AGVF IL GL LA LVA +E + S
Sbjct: 750 KDSGSKEKT-SALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS 792
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 341 bits (874), Expect = 2e-93
Identities = 244/861 (28%), Positives = 409/861 (47%), Gaps = 80/861 (9%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLM 83
I IG +F +++ F+ A+S L+ + K+ I ++ ++ F+ C
Sbjct: 25 IQIGGLFPNQQSQEHAAFRFALSQLT------EPPKLLPQIDIVNISDSFEMTYRFCSQF 78
Query: 84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPS---PDGEAYT 140
++G+ A+ + N L S A+H+ C + PS +
Sbjct: 79 SKGVYAIFGFYERRTVNMLTSFCGALHV----------------CFITPSFPVDTSNQFV 122
Query: 141 LASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKN 200
L RP L D ++ ++ +WQKFV YD++ + LQ LD A+ V+ +
Sbjct: 123 LQLRP--ELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT 180
Query: 201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
+ LF ++L + ++ L ++ + ++ + + ++ H++ N
Sbjct: 181 TEEGYRMLF-----QDLEKKKERL--VVVDCESERLNAILGQIIKLEKNGIGYHYILANL 233
Query: 261 EISDPEILDLVHSALG----RMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQML 316
D ++ S ++ P AK Q+ ++ R + + + Y L
Sbjct: 234 GFMDIDLNKFKESGANVTGFQLVNYTDTIP-AKIMQQWKNSDARDHTRVDWKRPKYTSAL 292
Query: 317 QISNLYLYDSVLMLANAFH---RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGH 373
YD V ++A AF R+ D A +C+ PW G + +++
Sbjct: 293 T------YDGVKVMAEAFQSLRRQRIDISRRGNAG-DCLANPAVPWGQGIDIQRALQQVR 345
Query: 374 ITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMG-- 431
GLTG ++F E ++ + +RK+ W+ + + + G
Sbjct: 346 FEGLTGNVQFNEKGRRTNYTLHVIEMKHD-----GIRKIGYWNEDDKFVPAATDAQAGGD 400
Query: 432 -SRLQGLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAP 488
S +Q T V T+LE+P+VM+ +N RY+G+ +++ +AK +G+ Y +
Sbjct: 401 NSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVS 460
Query: 489 DGRYGHQLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKK 547
DG+YG + +T +WNGM+GEL+ RAD+A++ +TIT RE V+DFSK +M + I+IKK
Sbjct: 461 DGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKK 520
Query: 548 PEE-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASAT-- 604
P++ K +FS P + +W CI A V V++F+++R S T
Sbjct: 521 PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSD 580
Query: 605 ------LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658
+ +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV
Sbjct: 581 QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 640
Query: 659 SRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718
RM +PI + +DL+KQ E++YGT+ + E+FR + + F ++W T K+
Sbjct: 641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRR------SKIAVFEKMW-TYMKSAEP 693
Query: 719 DNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQH 776
V + EG+ + + KG YA+L + + EY C +G ++ SKGYGIA
Sbjct: 694 SVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPK 752
Query: 777 GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836
GS R + +L+L + G LD LK KWW G C + + ++ +L L + AGVF
Sbjct: 753 GSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECG-SKDSGSKDKTSALSLSNVAGVFY 811
Query: 837 ILAIGLLLACLVAALELWWNS 857
IL GL LA LVA +E + S
Sbjct: 812 ILIGGLGLAMLVALIEFCYKS 832
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 340 bits (873), Expect = 3e-93
Identities = 244/861 (28%), Positives = 409/861 (47%), Gaps = 80/861 (9%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLM 83
I IG +F +++ F+ A+S L+ + K+ I ++ ++ F+ C
Sbjct: 25 IQIGGLFPNQQSQEHAAFRFALSQLT------EPPKLLPQIDIVNISDSFEMTYRFCSQF 78
Query: 84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPS---PDGEAYT 140
++G+ A+ + N L S A+H+ C + PS +
Sbjct: 79 SKGVYAIFGFYERRTVNMLTSFCGALHV----------------CFITPSFPVDTSNQFV 122
Query: 141 LASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKN 200
L RP L D ++ ++ +WQKFV YD++ + LQ LD A+ V+ +
Sbjct: 123 LQLRP--ELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT 180
Query: 201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
+ LF ++L + ++ L ++ + ++ + + ++ H++ N
Sbjct: 181 TEEGYRMLF-----QDLEKKKERL--VVVDCESERLNAILGQIIKLEKNGIGYHYILANL 233
Query: 261 EISDPEILDLVHSALG----RMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQML 316
D ++ S ++ P AK Q+ ++ R + + + Y L
Sbjct: 234 GFMDIDLNKFKESGANVTGFQLVNYTDTIP-AKIMQQWKNSDARDHTRVDWKRPKYTSAL 292
Query: 317 QISNLYLYDSVLMLANAFH---RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGH 373
YD V ++A AF R+ D A +C+ PW G + +++
Sbjct: 293 T------YDGVKVMAEAFQSLRRQRIDISRRGNAG-DCLANPAVPWGQGIDIQRALQQVR 345
Query: 374 ITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMG-- 431
GLTG ++F E ++ + +RK+ W+ + + + G
Sbjct: 346 FEGLTGNVQFNEKGRRTNYTLHVIEMKHD-----GIRKIGYWNEDDKFVPAATDAQAGGD 400
Query: 432 -SRLQGLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAP 488
S +Q T V T+LE+P+VM+ +N RY+G+ +++ +AK +G+ Y +
Sbjct: 401 NSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVS 460
Query: 489 DGRYGHQLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKK 547
DG+YG + +T +WNGM+GEL+ RAD+A++ +TIT RE V+DFSK +M + I+IKK
Sbjct: 461 DGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKK 520
Query: 548 PEE-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASAT-- 604
P++ K +FS P + +W CI A V V++F+++R S T
Sbjct: 521 PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSD 580
Query: 605 ------LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658
+ +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV
Sbjct: 581 QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 640
Query: 659 SRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718
RM +PI + +DL+KQ E++YGT+ + E+FR + + F ++W T K+
Sbjct: 641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRR------SKIAVFEKMW-TYMKSAEP 693
Query: 719 DNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQH 776
V + EG+ + + KG YA+L + + EY C +G ++ SKGYGIA
Sbjct: 694 SVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPK 752
Query: 777 GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836
GS R+ + +L+L + G LD LK KWW G C + ++ +L L + AGVF
Sbjct: 753 GSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNVAGVFY 811
Query: 837 ILAIGLLLACLVAALELWWNS 857
IL GL LA LVA +E + S
Sbjct: 812 ILIGGLGLAMLVALIEFCYKS 832
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 332 bits (852), Expect = 8e-91
Identities = 245/864 (28%), Positives = 404/864 (46%), Gaps = 76/864 (8%)
Query: 22 SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEAC 80
S + IG +F N ++ F+LA+ + + + ++ + + IE N F C
Sbjct: 25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84
Query: 81 DLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYT 140
++G+ A+ S + L S A+HI + G + L PS
Sbjct: 85 SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS------- 137
Query: 141 LASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKN 200
L +L L+ W FV YD++ LQ+ +++A + G VS V+
Sbjct: 138 --------LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVEN- 188
Query: 201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
F + EEL+R ++ ++ ++ + + + + V K H++ N
Sbjct: 189 ----FNDVSYRQLLEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242
Query: 261 EISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----CDPQE--GYL 313
D + +H + Q N + L+ D +E G
Sbjct: 243 GFKDISLERFIHGGA-----------NVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSE 291
Query: 314 QMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLN---CIRKSTKPWNGGRSMLDTIK 370
+ ++ YD VL++A F R L +K N C+ PW G M T+K
Sbjct: 292 TPPKYTSALTYDGVLVMAETF-RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLK 350
Query: 371 KGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPM 430
+ I GLTG ++F ++ E RK+ W+ L +
Sbjct: 351 QVRIQGLTGNVQFDHYGRRVNYTMDVF-----ELKSTGPRKVGYWNDMDKLVLIQDVPTL 405
Query: 431 GS---RLQGLTLKVVTVLEEPFVMVAEN--ILGQPKRYKGFSIDVLDALAKALGFKYEIY 485
G+ ++ T+ V T++E P+VM +N + +Y+G+ +D+ +AK +G KY+I
Sbjct: 406 GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA 465
Query: 486 QAPDGRYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL 544
PDG+YG + +T WNGM+GEL+ +A++AI+ +TIT RE V+DFSK +M + I+
Sbjct: 466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525
Query: 545 IKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR--------AQSAA 595
IKKP++ K +FS P + +W CI A V V++F+++R +
Sbjct: 526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGP 585
Query: 596 QPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAF 655
+P + +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAF
Sbjct: 586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 645
Query: 656 LTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKN 715
LTV RM +PI + +DL+KQ E++YGT+ + E+FR + + + ++W T ++
Sbjct: 646 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR------SKIAVYEKMW-TYMRS 698
Query: 716 GGADNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIA 773
+ +EG+ + + KG +AFL + + EY C +G ++ SKGYG+A
Sbjct: 699 AEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVA 757
Query: 774 LQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAG 833
GS + + +L+L + G LD LK KWW G C + ++ +L L + AG
Sbjct: 758 TPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNVAG 816
Query: 834 VFCILAIGLLLACLVAALELWWNS 857
VF IL GL LA LVA +E + S
Sbjct: 817 VFYILVGGLGLAMLVALIEFCYKS 840
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 332 bits (850), Expect = 1e-90
Identities = 245/864 (28%), Positives = 403/864 (46%), Gaps = 76/864 (8%)
Query: 22 SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEAC 80
S + IG +F N ++ F+LA+ + + + ++ + + IE N F C
Sbjct: 25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84
Query: 81 DLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYT 140
++G+ A+ S + L S A+HI + G + L PS
Sbjct: 85 SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS------- 137
Query: 141 LASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKN 200
L +L L+ W FV YD++ LQ+ +++A + G VS V+
Sbjct: 138 --------LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVEN- 188
Query: 201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
F + EEL+R ++ ++ ++ + + + + V K H++ N
Sbjct: 189 ----FNDVSYRQLLEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242
Query: 261 EISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----CDPQE--GYL 313
D + +H + Q N + L+ D +E G
Sbjct: 243 GFKDISLERFIHGGA-----------NVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSE 291
Query: 314 QMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLN---CIRKSTKPWNGGRSMLDTIK 370
+ ++ YD VL++A F R L +K N C+ PW G M T+K
Sbjct: 292 TPPKYTSALTYDGVLVMAETF-RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLK 350
Query: 371 KGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPM 430
+ I GLTG ++F ++ E RK+ W+ L +
Sbjct: 351 QVRIQGLTGNVQFDHYGRRVNYTMDVF-----ELKSTGPRKVGYWNDMDKLVLIQDVPTL 405
Query: 431 GS---RLQGLTLKVVTVLEEPFVMVAEN--ILGQPKRYKGFSIDVLDALAKALGFKYEIY 485
G+ ++ T+ V T++E P+VM +N + +Y+G+ +D+ +AK +G KY+I
Sbjct: 406 GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA 465
Query: 486 QAPDGRYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL 544
PDG+YG + +T WNGM+GEL+ +A++AI+ +TIT RE V+DFSK +M + I+
Sbjct: 466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525
Query: 545 IKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR--------AQSAA 595
IKKP++ K +FS P + +W CI A V V++F+++R +
Sbjct: 526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGP 585
Query: 596 QPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAF 655
+P + +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAF
Sbjct: 586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 645
Query: 656 LTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKN 715
LTV RM +PI + +DL+KQ E++YGT+ + E+FR + + + ++W T ++
Sbjct: 646 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR------SKIAVYEKMW-TYMRS 698
Query: 716 GGADNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIA 773
+ +EG+ + + KG +AFL + + EY C +G ++ SKGYG+A
Sbjct: 699 AEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVA 757
Query: 774 LQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAG 833
GS + +L+L + G LD LK KWW G C + ++ +L L + AG
Sbjct: 758 TPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECG-PKDSGSKDKTSALSLSNVAG 816
Query: 834 VFCILAIGLLLACLVAALELWWNS 857
VF IL GL LA LVA +E + S
Sbjct: 817 VFYILVGGLGLAMLVALIEFCYKS 840
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 327 bits (839), Expect = 3e-89
Identities = 245/861 (28%), Positives = 418/861 (48%), Gaps = 71/861 (8%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEACDL 82
I IG +F N ++ F+ AV + N + + + Y + ++++N F C
Sbjct: 34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQ 93
Query: 83 MTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLA 142
++G+ A+ S N L S A+H + +P P+ + +
Sbjct: 94 FSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV--------TPSF-----PTDADVQFVIQ 140
Query: 143 SRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNIS 202
RP L +L L+ +W+KFV YD+E LQ+ ++ A + V+ + V NI
Sbjct: 141 MRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVG-NIK 197
Query: 203 HV--FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
V F + EE++R ++ +R ++ + ++ + + V S+ H++ N
Sbjct: 198 DVQEFRRII-----EEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
Query: 261 EISDPEILDLVHSA--LGRMTVVRQIFPSAKDN-QKCTRNNHRISSLLCDPQEGYLQMLQ 317
+D + ++H + +V P + Q+ R + R + E L+
Sbjct: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER------EFPEAKNAPLK 304
Query: 318 ISNLYLYDSVLMLANAFH---RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHI 374
++ +D++L++A AF R+ D A +C+ PW+ G + +K +
Sbjct: 305 YTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAG-DCLANPAVPWSQGIDIERALKMVQV 363
Query: 375 TGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS-EKGLNGSLQERPMGSR 433
G+TG ++F ++ S + RK W+ E+ + S Q+ S
Sbjct: 364 QGMTGNIQFDTYGRRTNYTIDVYEMKVSGS-----RKAGYWNEYERFVPFSDQQISNDSA 418
Query: 434 L-QGLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDG 490
+ T+ V T+LE P+VM +N L +RY+G+ +D+ +AK + KY++ DG
Sbjct: 419 SSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDG 478
Query: 491 RYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE 549
+YG + T WNGM+GEL+ RAD+A++ +TIT RE V+DFSK +M + I+IKKP+
Sbjct: 479 KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 538
Query: 550 E-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR----------AQSAAQPR 598
+ K +FS P + +W CI A V V++F+++R + P
Sbjct: 539 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD 598
Query: 599 PSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658
P + +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV
Sbjct: 599 PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 658
Query: 659 SRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718
RM +PI + +DL+KQ E++YGT+ + E+FR + + + ++W + K+
Sbjct: 659 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR------SKIAVYEKMW-SYMKSAEP 711
Query: 719 DNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQH 776
+ ++G+ + + KG +AFL + + EY C +G ++ SKGYG+A
Sbjct: 712 SVFTKTTADGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVATPK 770
Query: 777 GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836
GS + + +L+L + G LD LK KWW G C + ++ +L L + AGVF
Sbjct: 771 GSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNVAGVFY 829
Query: 837 ILAIGLLLACLVAALELWWNS 857
IL GL LA +VA +E + S
Sbjct: 830 ILVGGLGLAMMVALIEFCYKS 850
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 327 bits (838), Expect = 3e-89
Identities = 246/861 (28%), Positives = 415/861 (48%), Gaps = 71/861 (8%)
Query: 24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEACDL 82
I IG +F N ++ F+ AV + N + + + Y + ++++N F C
Sbjct: 34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQ 93
Query: 83 MTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLA 142
++G+ A+ S N L S A+H + +P P+ + +
Sbjct: 94 FSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV--------TPSF-----PTDADVQFVIQ 140
Query: 143 SRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNIS 202
RP L +L L+ +W+KFV YD+E LQ+ ++ A + V+ + V NI
Sbjct: 141 MRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVG-NIK 197
Query: 203 HV--FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
V F + EE++R ++ +R ++ + ++ + + V S+ H++ N
Sbjct: 198 DVQEFRRII-----EEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL 250
Query: 261 EISDPEILDLVHSA--LGRMTVVRQIFPSAKDN-QKCTRNNHRISSLLCDPQEGYLQMLQ 317
+D + ++H + +V P + Q+ R + R + E L+
Sbjct: 251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER------EFPEAKNAPLK 304
Query: 318 ISNLYLYDSVLMLANAFH---RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHI 374
++ +D++L++A AF R+ D A +C+ PW+ G + +K +
Sbjct: 305 YTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAG-DCLANPAVPWSQGIDIERALKMVQV 363
Query: 375 TGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDS-EKGLNGSLQERPMGSR 433
G+TG ++F ++ S + RK W+ E+ + S Q+ S
Sbjct: 364 QGMTGNIQFDTYGRRTNYTIDVYEMKVSGS-----RKAGYWNEYERFVPFSDQQISNDSA 418
Query: 434 L-QGLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDG 490
+ T+ V T+LE P+VM +N L +RY+G+ +D+ +AK + KY++ DG
Sbjct: 419 SSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDG 478
Query: 491 RYGHQLHNTS-WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPE 549
+YG + T WNGM+GEL+ RAD+A++ +TIT RE V+DFSK +M + I+IKKP+
Sbjct: 479 KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 538
Query: 550 E-KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR----------AQSAAQPR 598
+ K +FS P + +W CI A V V++F+++R + P
Sbjct: 539 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD 598
Query: 599 PSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTV 658
P + +++W GAF+QQG + S S++ RIV G WW FTLI+ SSYTANLAAFLTV
Sbjct: 599 PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 658
Query: 659 SRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA 718
RM +PI + +DL+KQ E++YGT+ + E+FR + + + ++W + K+
Sbjct: 659 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR------SKIAVYEKMW-SYMKSAEP 711
Query: 719 DNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQH 776
+ ++G+ + + KG +AFL + + EY C +G ++ SKGYG+A
Sbjct: 712 SVFTKTTADGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVATPK 770
Query: 777 GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836
GS + +L+L + G LD LK KWW G C S +L L + AGVF
Sbjct: 771 GSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKT-SALSLSNVAGVFY 829
Query: 837 ILAIGLLLACLVAALELWWNS 857
IL GL LA +VA +E + S
Sbjct: 830 ILVGGLGLAMMVALIEFCYKS 850
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 298 bits (762), Expect = 2e-80
Identities = 190/556 (34%), Positives = 287/556 (51%), Gaps = 39/556 (7%)
Query: 318 ISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGL 377
+S ++D+V ++ +A R+L + + L C S W G S+++ ++ GL
Sbjct: 302 LSAALMFDAVHVVVSAV-RELNRSQEIGVKPLACT--SANIWPHGTSLMNYLRMVEYDGL 358
Query: 378 TGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL--NGSLQERPMGSRLQ 435
TG +EF IL E + R++ W S + L N + + + L
Sbjct: 359 TGRVEFNSKGQRTNYTLRIL-----EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLA 413
Query: 436 GLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYG 493
TL V T+LE P+VM N L +R++GF +D+L LA+ L F+Y + DG YG
Sbjct: 414 NKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG 473
Query: 494 HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIK-KPEEKI 552
N SW GM+GELI+++ADLA++A TIT ERE V+DFSK +M + IL + K
Sbjct: 474 APEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKP 533
Query: 553 SIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA--------- 603
FS PF AVW + A V ++F+ R+ + P P A
Sbjct: 534 GYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYN---PHPCLRARPHILENQY 590
Query: 604 TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDN 663
TL +++W G F+QQG E +++ R V G WW FTLI+ SSYTANLAAFLTV RM+
Sbjct: 591 TLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEV 650
Query: 664 PIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVS 723
P+ + DL+ Q + YGT+ + +F+ + T+ +W + ++ V
Sbjct: 651 PVESADDLADQTNIEYGTIHAGSTMTFFQN------SRYQTYQRMWNYM-QSKQPSVFVK 703
Query: 724 SPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDL 783
S EGI + YAFL + + EY +C++T IG + +KGYGI + GSP+RD
Sbjct: 704 STEEGIARVLNSRYAFLLESTMNEYHRRL--NCNLTQIGGLLDTKGYGIGMPLGSPFRDE 761
Query: 784 FSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLL 843
+ IL+LQ+ L++LK+KWW GRC A K L + + G+F +L GL+
Sbjct: 762 ITLAILQLQENNRLEILKRKWW-EGGRCPKEEDHRA----KGLGMENIGGIFIVLICGLI 816
Query: 844 LACLVAALELWWNSNR 859
+A VA +E W++ R
Sbjct: 817 IAVFVAVMEFIWSTRR 832
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 297 bits (760), Expect = 4e-80
Identities = 257/929 (27%), Positives = 422/929 (45%), Gaps = 105/929 (11%)
Query: 4 LTLWLLPWICQCVSVRADSIIHIGAIFEE--NAAKDDRV-FQLAVSDLSLNDDILQSEKI 60
L WL+ C S+R I AI ++ ++ +R+ LA + ++ + L K+
Sbjct: 11 LPAWLVMVACSPHSLR------IAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKV 64
Query: 61 TYSIKVIEANNPFQAVQEACDLMTQGILALV-TSTGCASANALQSLTDAMHIPHLFVQRN 119
I + ++ ++ + C ++ +G++A++ S+ AS++ + ++ +PH V
Sbjct: 65 EVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPE 124
Query: 120 PGGSPR----TACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDI 175
+ T +L+PS + +A ++ + +
Sbjct: 125 EFVKFQFQRFTTLNLHPSNTDISVAVAG------------ILNFFNCTTACLICAKAECL 172
Query: 176 RGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILL-LSPQ 234
L+ L Q +S++ +D T T L RD I++ +
Sbjct: 173 LNLEKLLRQFLISKDTLSVRMLDD----------TRDPTPLLKEIRDDKTATIIIHANAS 222
Query: 235 GAHSFINEAVETNLASKDSHWVFVNEEIS--------DPEILDLVHSALGRMTVVRQIFP 286
+H+ + +A E + S ++F N E S D + L S + Q F
Sbjct: 223 MSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFA 282
Query: 287 SAKDNQKCTRNNHRISSLLCD--PQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWH 344
+ NQ N CD P G +S+ L+D+V + A ++L +
Sbjct: 283 QSL-NQSWQEN--------CDHVPFTGPA----LSSALLFDAVYAVVTAV-QELNRSQEI 328
Query: 345 SMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSET 404
+ L+C S + W G S+++ ++ + GLTG +EF +IL T +
Sbjct: 329 GVKPLSC--GSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRN-- 384
Query: 405 FGKDMRKLATWDSEKGLN--GSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENI--LGQP 460
R++ W +GL+ L + L TL V T+LE P++M+ N +
Sbjct: 385 ---GFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGN 441
Query: 461 KRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAI 520
RY+GF +D+L LA+ L F Y+I DG YG N +W GM+GELI+++ADLA++ +
Sbjct: 442 DRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGL 501
Query: 521 TITPERESVVDFSKRYMDYSVGILIK-KPEEKISIFSLFAPFDFAVWACIAAAIPVVGVL 579
TIT ERE V+DFSK +M + IL + K FS PF VW + A V +
Sbjct: 502 TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCV 561
Query: 580 IFVLNRIQAVRAQSAAQPRPSASA---------TLHSAIWIVYGAFVQQGGESSVNSMAM 630
+F++ R+ S P P A +L +++W G F+QQG + +++
Sbjct: 562 LFLVARLTPYEWYS---PHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALST 618
Query: 631 RIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEY 690
R V G WW FTLI+ SSYTANLAAFLTV RMD PI + DL+ Q + YGT+ + +
Sbjct: 619 RCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTF 678
Query: 691 FRAKGTNPLEQDSTFAELWRTI-SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYA 749
F+ + T+ +W + SK V S EGI + NYAFL + + EY
Sbjct: 679 FQN------SRYQTYQRMWNYMYSKQPSV--FVKSTEEGIARVLNSNYAFLLESTMNEY- 729
Query: 750 ALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMG 809
+C++T IG + +KGYGI + GS +RD F IL+LQ+ L++LK+KWW G
Sbjct: 730 -YRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGG 787
Query: 810 RCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDK 869
+C A K L + + G+F +L GL++A +A LE W H E +
Sbjct: 788 KCPKEEDHRA----KGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR--HSEA--TEV 839
Query: 870 EVNLEQVHRRMNSLMDEDIAHKQISPASI 898
V E V + ++ +D H + A++
Sbjct: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAV 868
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 203 bits (517), Expect = 6e-52
Identities = 167/639 (26%), Positives = 291/639 (45%), Gaps = 89/639 (13%)
Query: 313 LQMLQISN--LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK 370
LQ++ N ++ D+V ++A A H LE C+ +T W G +
Sbjct: 269 LQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG-NTNIWKTGPLFKRVLM 326
Query: 371 KG-HITGLTGVMEFREDSSNPYVQFEILGTT---------YSETFGKDMRKLATWDSEKG 420
+ G+TG +EF ED + + I+ Y+ T + W
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWP---- 382
Query: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENIL----------------------- 457
G E+P G ++ LK+VT+ +EPFV V +
Sbjct: 383 --GGETEKPRGYQMS-TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGP 439
Query: 458 -----GQPKRYK-----GFSIDVLDALAKALGFKYEIYQAPDGRYGHQ--LHNTS---WN 502
G P+ GF ID+L LA+ + F YE++ DG++G Q ++N++ WN
Sbjct: 440 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN 499
Query: 503 GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFD 562
GM+GEL+S +AD+ ++ +TI ER ++FSK + + IL+KK + ++ S PF
Sbjct: 500 GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQ 559
Query: 563 FAVWACIAAAIPVVGVLIFVLNRIQAV-RAQSAAQPRPSASATLHSAIWIVYGAFVQQG- 620
+W + ++ VV V++++L+R R + ++ + TL SA+W +G + G
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGI 619
Query: 621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD---LSKQVEM 677
GE + S + RI+ W F +I+ +SYTANLAAFL + R + I D + +
Sbjct: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
Query: 678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGN- 736
Y TV+ S+V YFR + + ++R + K+ S +E I+ +
Sbjct: 680 IYATVKQSSVDIYFR--------RQVELSTMYRHMEKHN-----YESAAEAIQAVRDNKL 726
Query: 737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796
+AF+WD AV+E+ A C + G G+GI ++ SP++ S IL+ + G
Sbjct: 727 HAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 784
Query: 797 LDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856
++ L K W CD S+A A +L + AGVF ++A G++ + +E+
Sbjct: 785 MEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEI--- 835
Query: 857 SNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISP 895
+ + H++ ++ ++ V+ +L D + P
Sbjct: 836 AYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDP 874
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 202 bits (513), Expect = 2e-51
Identities = 162/603 (26%), Positives = 278/603 (46%), Gaps = 86/603 (14%)
Query: 313 LQMLQISN--LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK 370
LQ++ N ++ D+V ++A A H LE C+ +T W G +
Sbjct: 269 LQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG-NTNIWKTGPLFKRVLM 326
Query: 371 KG-HITGLTGVMEFREDSSNPYVQFEILGTT---------YSETFGKDMRKLATWDSEKG 420
+ G+TG +EF ED + + I+ Y+ T + W
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWP---- 382
Query: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENIL----------------------- 457
G E+P G ++ LK+VT+ +EPFV V +
Sbjct: 383 --GGETEKPRGYQMS-TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGP 439
Query: 458 -----GQPKRYK-----GFSIDVLDALAKALGFKYEIYQAPDGRYGHQ--LHNTS---WN 502
G P+ GF ID+L LA+ + F YE++ DG++G Q ++N++ WN
Sbjct: 440 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN 499
Query: 503 GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFD 562
GM+GEL+S +AD+ ++ +TI ER ++FSK + + IL+KK + ++ S PF
Sbjct: 500 GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQ 559
Query: 563 FAVWACIAAAIPVVGVLIFVLNRIQAV-RAQSAAQPRPSASATLHSAIWIVYGAFVQQG- 620
+W + ++ VV V++++L+R R + ++ + TL SA+W +G + G
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGI 619
Query: 621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD---LSKQVEM 677
GE + S + RI+ W F +I+ +SYTANLAAFL + R + I D + +
Sbjct: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
Query: 678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGN- 736
Y TV+ S+V YFR + + ++R + K+ S +E I+ +
Sbjct: 680 IYATVKQSSVDIYFR--------RQVELSTMYRHMEKHN-----YESAAEAIQAVRDNKL 726
Query: 737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796
+AF+WD AV+E+ A C + G G+GI ++ SP++ S IL+ + G
Sbjct: 727 HAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 784
Query: 797 LDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856
++ L K W CD S+A A +L + AGVF ++A G++ + +E+ +
Sbjct: 785 MEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
Query: 857 SNR 859
++
Sbjct: 839 RHK 841
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 202 bits (513), Expect = 2e-51
Identities = 162/603 (26%), Positives = 278/603 (46%), Gaps = 86/603 (14%)
Query: 313 LQMLQISN--LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK 370
LQ++ N ++ D+V ++A A H LE C+ +T W G +
Sbjct: 269 LQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG-NTNIWKTGPLFKRVLM 326
Query: 371 KG-HITGLTGVMEFREDSSNPYVQFEILGTT---------YSETFGKDMRKLATWDSEKG 420
+ G+TG +EF ED + + I+ Y+ T + W
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWP---- 382
Query: 421 LNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENIL----------------------- 457
G E+P G ++ LK+VT+ +EPFV V +
Sbjct: 383 --GGETEKPRGYQMS-TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGP 439
Query: 458 -----GQPKRYK-----GFSIDVLDALAKALGFKYEIYQAPDGRYGHQ--LHNTS---WN 502
G P+ GF ID+L LA+ + F YE++ DG++G Q ++N++ WN
Sbjct: 440 NDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWN 499
Query: 503 GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFD 562
GM+GEL+S +AD+ ++ +TI ER ++FSK + + IL+KK + ++ S PF
Sbjct: 500 GMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQ 559
Query: 563 FAVWACIAAAIPVVGVLIFVLNRIQAV-RAQSAAQPRPSASATLHSAIWIVYGAFVQQG- 620
+W + ++ VV V++++L+R R + ++ + TL SA+W +G + G
Sbjct: 560 STLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGI 619
Query: 621 GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD---LSKQVEM 677
GE + S + RI+ W F +I+ +SYTANLAAFL + R + I D + +
Sbjct: 620 GEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 679
Query: 678 SYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGN- 736
Y TV+ S+V YFR + + ++R + K+ S +E I+ +
Sbjct: 680 IYATVKQSSVDIYFR--------RQVELSTMYRHMEKHN-----YESAAEAIQAVRDNKL 726
Query: 737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGD 796
+AF+WD AV+E+ A C + G G+GI ++ SP++ S IL+ + G
Sbjct: 727 HAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 784
Query: 797 LDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856
++ L K W CD S+A A +L + AGVF ++A G++ + +E+ +
Sbjct: 785 MEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEIAYK 838
Query: 857 SNR 859
++
Sbjct: 839 RHK 841
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 164 bits (415), Expect = 4e-40
Identities = 119/423 (28%), Positives = 207/423 (48%), Gaps = 41/423 (9%)
Query: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
KGF ID+L LA +GF Y++Y +G++G ++ WNGMIGE+ +RAD+AI ++TI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGV-WNGMIGEVFYQRADMAIGSLTIN 543
Query: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACI-AAAIPVVGVLIFV 582
ER +VDFS +++ + +++ + +S + P+ AVW + + VV V +F+
Sbjct: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFI 603
Query: 583 LNRIQAV--RAQSAAQPRPSASA-TLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
+ V A RP S T+ +IW+++ F + +I++ W
Sbjct: 604 FEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWA 663
Query: 639 LFTLIVCSSYTANLAAFL-------TVSRMDNPIRTFQDLSKQV-EMSYGTVRDSAVYEY 690
F +I +SYTANLAAF+ TVS + + R FQ +Q + +GTV + + +
Sbjct: 664 FFAVIFLASYTANLAAFMIQEEYVDTVSGLSD--RKFQRPQEQYPPLKFGTVPNGSTEKN 721
Query: 691 FRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYA 749
R S + ++ + + E + + K G AF++D AV+ Y
Sbjct: 722 IR----------SNYPDMHSYMVRYN-----QPRVEEALTQLKAGKLDAFIYDAAVLNYM 766
Query: 750 ALTDDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPH 807
A D+ C + IG+ ++ GYGIAL GS ++ +L+ ++++L++ W
Sbjct: 767 ARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSG 826
Query: 808 MGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRCHQETP 865
+ D S++ D + + AGVF +L + + L+ LV A E ++W C T
Sbjct: 827 ICHNDKIEVMSSKLD-----IDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTH 881
Query: 866 KED 868
+ D
Sbjct: 882 RMD 884
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 162 bits (410), Expect = 1e-39
Identities = 111/412 (26%), Positives = 195/412 (47%), Gaps = 35/412 (8%)
Query: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
KGF ID+L L++ + F Y++Y +G++G +++N WNGMIGE++ +RA +A+ ++TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNGMIGEVVYQRAVMAVGSLTIN 515
Query: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFV 582
ER VVDFS +++ + +++ + +S + PF +VW + + +V + +FV
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV 575
Query: 583 LNRIQAV---RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
V R + + S T+ AIW+++G F + +I++ W
Sbjct: 576 FEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 635
Query: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSY------GTVRDSAVYEYFR 692
F +I +SYTANLAAF+ + + D Q Y GTV + + R
Sbjct: 636 FFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR 695
Query: 693 AKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALT 752
+ + + T G ++ + S G AF++D AV+ Y A
Sbjct: 696 --------NNYPYMHQYMTKFNQKGVEDALVSLKTGKLD------AFIYDAAVLNYKAGR 741
Query: 753 DDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGR 810
D+ C + IG+ ++ GYGIALQ GSP++ +L+ G+++ L+ W +
Sbjct: 742 DEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801
Query: 811 CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
+ S+Q D + + AGVF +LA + L+ + E +W C
Sbjct: 802 NEKNEVMSSQLD-----IDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFC 848
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 162 bits (410), Expect = 1e-39
Identities = 111/412 (26%), Positives = 195/412 (47%), Gaps = 35/412 (8%)
Query: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
KGF ID+L L++ + F Y++Y +G++G +++N WNGMIGE++ +RA +A+ ++TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNGMIGEVVYQRAVMAVGSLTIN 515
Query: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFV 582
ER VVDFS +++ + +++ + +S + PF +VW + + +V + +FV
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV 575
Query: 583 LNRIQAV---RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
V R + + S T+ AIW+++G F + +I++ W
Sbjct: 576 FEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 635
Query: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSY------GTVRDSAVYEYFR 692
F +I +SYTANLAAF+ + + D Q Y GTV + + R
Sbjct: 636 FFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR 695
Query: 693 AKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALT 752
+ + + T G ++ + S G AF++D AV+ Y A
Sbjct: 696 --------NNYPYMHQYMTKFNQKGVEDALVSLKTGKLD------AFIYDAAVLNYKAGR 741
Query: 753 DDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGR 810
D+ C + IG+ ++ GYGIALQ GSP++ +L+ G+++ L+ W +
Sbjct: 742 DEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801
Query: 811 CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
+ S+Q D + + AGVF +LA + L+ + E +W C
Sbjct: 802 NEKNEVMSSQLD-----IDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFC 848
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 162 bits (410), Expect = 1e-39
Identities = 111/412 (26%), Positives = 195/412 (47%), Gaps = 35/412 (8%)
Query: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
KGF ID+L L++ + F Y++Y +G++G +++N WNGMIGE++ +RA +A+ ++TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNGMIGEVVYQRAVMAVGSLTIN 515
Query: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFV 582
ER VVDFS +++ + +++ + +S + PF +VW + + +V + +FV
Sbjct: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV 575
Query: 583 LNRIQAV---RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
V R + + S T+ AIW+++G F + +I++ W
Sbjct: 576 FEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 635
Query: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSY------GTVRDSAVYEYFR 692
F +I +SYTANLAAF+ + + D Q Y GTV + + R
Sbjct: 636 FFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR 695
Query: 693 AKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALT 752
+ + + T G ++ + S G AF++D AV+ Y A
Sbjct: 696 --------NNYPYMHQYMTKFNQKGVEDALVSLKTGKLD------AFIYDAAVLNYKAGR 741
Query: 753 DDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGR 810
D+ C + IG+ ++ GYGIALQ GSP++ +L+ G+++ L+ W +
Sbjct: 742 DEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801
Query: 811 CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
+ S+Q D + + AGVF +LA + L+ + E +W C
Sbjct: 802 NEKNEVMSSQLD-----IDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFC 848
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 162 bits (410), Expect = 1e-39
Identities = 125/466 (26%), Positives = 211/466 (45%), Gaps = 66/466 (14%)
Query: 439 LKVVTVLEEPFVMV----------------------AENILGQPKRY-----KGFSIDVL 471
L +VT+ E PFV+V EN + Y KGF ID+L
Sbjct: 406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDIL 465
Query: 472 DALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVD 531
++K++ F Y++Y +G++G +++ T WNGMIGE++ KRA +A+ ++TI ER VVD
Sbjct: 466 KKISKSVKFTYDLYLVTNGKHGKKINGT-WNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524
Query: 532 FSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFVLNRIQAV- 589
FS +++ + +++ + +S + PF VW + + +V V +FV V
Sbjct: 525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584
Query: 590 --RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCS 646
R + + S T+ AIW+++G F + +I++ W F +I +
Sbjct: 585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLA 644
Query: 647 SYTANLAAFLTVSRMDNPIRTFQDLSKQ------VEMSYGTVRDSAVYEYFRAKGTNPLE 700
SYTANLAAF+ + + D Q +GTV + + R
Sbjct: 645 SYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR-------- 696
Query: 701 QDSTFAELWRTISK--NGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSV 758
+ +AE+ + K G D+ + S G AF++D AV+ Y A D+ C +
Sbjct: 697 --NNYAEMHAYMGKFNQRGVDDALLSLKTGKLD------AFIYDAAVLNYMAGRDEGCKL 748
Query: 759 TVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSH 816
IG+ +S GYGIA+Q S ++ IL+L G+++ L+ W + +
Sbjct: 749 VTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEV 808
Query: 817 ASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
S+Q D + + AGVF +L + L+ + E +W C
Sbjct: 809 MSSQLD-----IDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHC 849
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 149 bits (375), Expect = 2e-35
Identities = 110/406 (27%), Positives = 192/406 (47%), Gaps = 33/406 (8%)
Query: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
KGF ID+L LA+ + F Y++Y +G++G ++ WNGMIGE+ KRAD+AI ++TI
Sbjct: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV-WNGMIGEVYYKRADMAIGSLTIN 513
Query: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACI-AAAIPVVGVLIFV 582
ER +VDFS +++ + +++ + +S + P+ AVW + + VV + +F+
Sbjct: 514 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFM 573
Query: 583 LNRIQAVR-AQSAAQPRPSA--SATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
V Q+ + + S + T+ ++W+++ F + +I++ W
Sbjct: 574 FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWA 633
Query: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFR----AK 694
F +I +SYTANLAAF+ + + + D Q R Y FR
Sbjct: 634 FFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQ--------RPQDQYPPFRFGTVPN 685
Query: 695 GTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYAALTD 753
G+ S + ++ + K S + + K G AF++D AV+ Y A D
Sbjct: 686 GSTERNIRSNYRDMHTHMVKFN-----QRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKD 740
Query: 754 DDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRC 811
+ C + IG+ ++ GYGIA+Q S ++ +L+ G+ L+ W G C
Sbjct: 741 EGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL--SGIC 798
Query: 812 DLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWW 855
+ + L + + AGVF +L + + LA LV A E ++W
Sbjct: 799 ---QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYW 841
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 140 bits (354), Expect = 5e-33
Identities = 106/402 (26%), Positives = 187/402 (46%), Gaps = 51/402 (12%)
Query: 465 GFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITP 524
G+ ID+L+ LA+ F +E+Y DG+YG L + W G++G+L++ RA +A+++ +I
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYG-ALRDGRWTGLVGDLLAGRAHMAVTSFSINS 536
Query: 525 ERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584
R VVDF+ + S+GI+++ + I + P ++ W + AA+ + + + V
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYE 596
Query: 585 RIQAVRAQSAAQPRPSASATL---HSAIWIVYGAFVQQGGESSVNSMAM-RIVMGSWWLF 640
R+ PR +T+ SA+ + Y ++ S R++M W +F
Sbjct: 597 ----WRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIF 652
Query: 641 TLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS---------KQVEMSYGTVRDSAVYEYF 691
L+V SSYTANLAA + +TF++LS +GTV +S+ Y
Sbjct: 653 CLLVLSSYTANLAAVMVGD------KTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYI 706
Query: 692 RAKGTNPLEQDSTFAELWRTISKNG------GADNCVSSPSEGIRKAKKGNYAFLWDVAV 745
+ +F ++ + ++ G S P + AF+ D ++
Sbjct: 707 K----------KSFPDMHAHMRRHSAPTTPRGVAMLTSDPPK--------LNAFIMDKSL 748
Query: 746 VEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWW 805
++Y D DC + +G + +GYGI L SP S+ I + +G +D+L KW+
Sbjct: 749 LDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY 808
Query: 806 PHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACL 847
M C A + + ++ FAG+F +L +GL A L
Sbjct: 809 -KMVPCG--KRVFAVTETLQMSIYHFAGLFVLLCLGLGSALL 847
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 135 bits (341), Expect = 1e-31
Identities = 129/552 (23%), Positives = 231/552 (41%), Gaps = 70/552 (12%)
Query: 347 ASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFG 406
+++NC+ T G+ + + GL+G + + + + + G
Sbjct: 415 STMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMG 474
Query: 407 KDM-RKLATWDSEKGLN--GSLQERPMGSRLQ-----GLTLKVVTVLEEPFVMVAENI-- 456
K M +L +W K + G E+ + L L+VVT++E PFV E
Sbjct: 475 KPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDE 534
Query: 457 ----LGQ---------------------------PKRYK----GFSIDVLDALAKALGFK 481
GQ P ++K G+ ID+L+ +A+ + F
Sbjct: 535 GLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFD 594
Query: 482 YEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSV 541
+++Y DG+YG N W G++G+L+ A +A+++ +I R V+DF+ + S+
Sbjct: 595 FDLYIVGDGKYG-AWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSL 653
Query: 542 GILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSA 601
GIL++ + I + P + +W I A+ + V + + + R S
Sbjct: 654 GILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNR-SK 712
Query: 602 SATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
+ SA+ I Y F + R +M W +F + S+YTANLAA + +
Sbjct: 713 VFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEK 772
Query: 661 MDNPIRTFQDLS---KQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGG 717
+ + D +GTVR+S+ +Y R +F E+ + +
Sbjct: 773 IYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVR----------QSFPEMHEYMRRY-- 820
Query: 718 ADNCVSSPS--EGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQ 775
N ++P E ++ + AF+ D A+++Y D DC + +G + +GYGI L
Sbjct: 821 --NVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLP 878
Query: 776 HGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVF 835
SP S+ I + + G +D+L KW+ + C S A + +K F+G+F
Sbjct: 879 PNSPLTANISELISQYKSHGFMDMLHDKWY-RVVPCGKRSFAVTETLQMGIK--HFSGLF 935
Query: 836 CILAIGLLLACL 847
+L IG L+ L
Sbjct: 936 VLLCIGFGLSIL 947
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 68.9 bits (167), Expect = 2e-11
Identities = 80/373 (21%), Positives = 142/373 (38%), Gaps = 45/373 (12%)
Query: 22 SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE-KITYSIKVIEANNPFQAVQEAC 80
S + IG +F N ++ F+LA+ + + + ++ + + IE N F C
Sbjct: 25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84
Query: 81 DLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYT 140
++G+ A+ S + L S A+HI + G + L PS
Sbjct: 85 SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS------- 137
Query: 141 LASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKN 200
L +L L+ W FV YD++ LQ+ +++A + G VS V+
Sbjct: 138 --------LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVEN- 188
Query: 201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNE 260
F + EEL+R ++ ++ ++ + + + + V K H++ N
Sbjct: 189 ----FNDVSYRQLLEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242
Query: 261 EISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----CDPQE--GYL 313
D + +H + Q N + L+ D +E G
Sbjct: 243 GFKDISLERFIHGG-----------ANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSE 291
Query: 314 QMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLN---CIRKSTKPWNGGRSMLDTIK 370
+ ++ YD VL++A F R L +K N C+ PW G M T+K
Sbjct: 292 TPPKYTSALTYDGVLVMAETF-RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLK 350
Query: 371 KGHITGLTGVMEF 383
+ I GLTG ++F
Sbjct: 351 QVRIQGLTGNVQF 363
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,164,388
Number of Sequences: 37866
Number of extensions: 1654192
Number of successful extensions: 4811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4550
Number of HSP's gapped (non-prelim): 90
length of query: 1009
length of database: 18,247,518
effective HSP length: 112
effective length of query: 897
effective length of database: 14,006,526
effective search space: 12563853822
effective search space used: 12563853822
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.