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Search of human proteins with 55770834
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55770834 centromere protein F [Homo sapiens]
(3114 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55770834 centromere protein F [Homo sapiens] 5992 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 355 3e-97
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 286 3e-76
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 285 5e-76
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 284 8e-76
gi|21735548 centrosomal protein 2 [Homo sapiens] 265 4e-70
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 243 3e-63
gi|71061468 centromere protein E [Homo sapiens] 238 7e-62
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 211 1e-53
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 204 1e-51
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 202 3e-51
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 198 6e-50
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 196 3e-49
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 195 7e-49
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 195 7e-49
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 195 7e-49
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 195 7e-49
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 195 7e-49
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 187 1e-46
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 187 2e-46
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 186 2e-46
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 186 3e-46
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 186 3e-46
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 186 3e-46
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 183 2e-45
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 181 8e-45
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 180 2e-44
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 180 2e-44
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 179 3e-44
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 179 4e-44
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 5992 bits (15545), Expect = 0.0
Identities = 3114/3114 (100%), Positives = 3114/3114 (100%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT
Sbjct: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
Query: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR
Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
Query: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR
Sbjct: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
Query: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
Query: 241 FSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR 300
FSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR
Sbjct: 241 FSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR 300
Query: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 361 EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR 420
EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR
Sbjct: 361 EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR 420
Query: 421 LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS 480
LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS
Sbjct: 421 LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS 480
Query: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 541 QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600
QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS
Sbjct: 541 QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600
Query: 601 ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE 660
ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE
Sbjct: 601 ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE 660
Query: 661 YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN
Sbjct: 661 YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ 1020
IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ 1020
Query: 1021 EKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAK 1080
EKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAK
Sbjct: 1021 EKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAK 1080
Query: 1081 EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN 1140
EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN
Sbjct: 1081 EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN 1140
Query: 1141 KMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE 1200
KMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE
Sbjct: 1141 KMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE 1200
Query: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
Query: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 1321 LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS 1380
LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS
Sbjct: 1321 LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS 1380
Query: 1381 LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD 1440
LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD
Sbjct: 1381 LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD 1440
Query: 1441 SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500
SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL
Sbjct: 1441 SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500
Query: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560
EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560
Query: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM
Sbjct: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
Query: 1621 ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680
ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE
Sbjct: 1621 ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680
Query: 1681 TTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQ 1740
TTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQ
Sbjct: 1681 TTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQ 1740
Query: 1741 GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESL 1800
GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESL
Sbjct: 1741 GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESL 1800
Query: 1801 LNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV 1860
LNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV
Sbjct: 1801 LNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV 1860
Query: 1861 ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY
Sbjct: 1861 ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
Query: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL 1980
LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL
Sbjct: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL 1980
Query: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL 2040
SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL 2040
Query: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 2221 EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280
EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE
Sbjct: 2221 EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280
Query: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN 2340
IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN 2340
Query: 2341 LERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNE 2400
LERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNE
Sbjct: 2341 LERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNE 2400
Query: 2401 LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND 2460
LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND
Sbjct: 2401 LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND 2460
Query: 2461 QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK
Sbjct: 2461 QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
Query: 2521 DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580
DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ
Sbjct: 2521 DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580
Query: 2581 DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS 2640
DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS
Sbjct: 2581 DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS 2640
Query: 2641 GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ 2700
GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ
Sbjct: 2641 GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQ 2700
Query: 2701 LRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL 2760
LRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL
Sbjct: 2701 LRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL 2760
Query: 2761 KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ
Sbjct: 2761 KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
Query: 2821 AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM
Sbjct: 2821 AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 2881 LETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWE 2940
LETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWE
Sbjct: 2881 LETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWE 2940
Query: 2941 NGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPY 3000
NGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPY
Sbjct: 2941 NGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPY 3000
Query: 3001 ILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRSPVDSGT 3060
ILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRSPVDSGT
Sbjct: 3001 ILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRSPVDSGT 3060
Query: 3061 ILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ 3114
ILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ
Sbjct: 3061 ILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ 3114
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 355 bits (912), Expect = 3e-97
Identities = 658/3154 (20%), Positives = 1276/3154 (40%), Gaps = 555/3154 (17%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
+++ E + +LK +Q+ QL + ALQ++++ +N K + L + +L + +
Sbjct: 52 ERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADN-KIKKLKLHAK-AKLTSLNK 109
Query: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
+E+ K + L + E QL+ K + E E+++ K +L+ ++ +
Sbjct: 110 YIEEMKAQGGTVLPTEPQS----EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA 165
Query: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYED---LKEKYNKEVEERKRLEAEVKALQAKKAS 194
L Q P+Q S ++ E+ +K++ ++ E L+A++ QA++A+
Sbjct: 166 QLTQAQAEQ--------PAQ--SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
Query: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTP 254
Q + + +D AR + + + + + ++ R E+ +
Sbjct: 216 QQV----VREKD-ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
+ + +++ ++ N L Q++A++ LRN + E+E
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET--------ERE------- 315
Query: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA-------STKYTALEQKLK-- 365
E ++ LEK ++E+ E++ + ++E+ Q++QA ++Y+ALEQK K
Sbjct: 316 --ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373
Query: 366 ------------------------------KLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
KL +D + Q + LE ++++K KE
Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433
Query: 396 FQEELSR---------QQRSF--------QTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
+ L+R Q SF Q + +E I + EL+ K + E
Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK----ENELRRSMEEMKK---ENNLL 491
L++L + ++L + + + + E + S+I N+ S EE + EN
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 492 KSHSE------------------------QKAREVCHLEAELKNIKQCLNQS-------- 519
+ H E ++A E H + K +KQ +
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
Query: 520 --QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE---------KQRD 568
++ ++ + ++ +E+ + + S T E++ L A +E K
Sbjct: 614 FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 569 CSQDLLKKREHHIEQLNDKLSKTE----KESKALLSALELKKKEYEELKEEKTLFSCWKS 624
D+ + + +E+L ++ + E K + L+ K KE L + F
Sbjct: 674 AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733
Query: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQ-QIKSHEYN--------------------- 662
N T + E++ L S++ L + + Q+K E N
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
Query: 663 --ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
E++ +L ++ ++ V+I L N LD ++ Q LQ + Q + E+
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL----QNKESEVLE 849
Query: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV-TNED 779
+ ++ +VE+L L EI D+ + + E+L+ ++ KD + +
Sbjct: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
Query: 780 HQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLE--ADQSPKNSAILQNRVDSLEF 837
++ +++ + EQ ++ S E + E + + +S + QN +
Sbjct: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA 969
Query: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
S++++ + +E Q K +++ L+ + E QR+S+L+E
Sbjct: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRK--------ELLQRVSRLEE------- 1014
Query: 898 VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE----DSLKELQL-LSETLS 952
E + + +KE+ L ETE+ E++E K++ E +E+++ L +T+S
Sbjct: 1015 ---ELANLKDESKKEIPL----SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS 1067
Query: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012
++ E+ I + ++ Q +K++N +L + N ID + IS
Sbjct: 1068 EKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDK-----------TNQIDLLQAEIS 1116
Query: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
E +Q +KLI T N D S A K + + + CT E+ K ELE
Sbjct: 1117 E--NQAIIQKLI-------TSNT--DASDGDSVALVKETVV--ISPPCTGSSEHWKPELE 1163
Query: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM---TDNQNNSKSEAGGLK 1129
+ A KE ++ KL A + ++ + + ++ LR E+ D+ N + +
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS 1223
Query: 1130 QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES----ER 1185
+E + ++ ++Q +V + + ++ LE EP+ + ++ + E
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE-EPLFKATEQHHTQPVLES 1282
Query: 1186 NQCNFKPQMDLEVKEI----SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI 1241
N C P + + S+ AQL ++EA ELK+ + E E+ +
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342
Query: 1242 RGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301
+ + + Q EI LK +AE S +L +SQ A L+ L+ KL+
Sbjct: 1343 QEQI------NKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLRELQPKLD 1395
Query: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL---HG 1358
EL+K L ++K E V+ L+ SE A K+ E+ + + +K L+ + H
Sbjct: 1396 ELQK----LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD 1451
Query: 1359 ELVEDIPGG--EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL---- 1412
E ++ + E ++P E S A + +S KE LQE+
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
Query: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL 1472
+++ K L D Q+S++ E T + L L+ + L+ EM L E
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLAL--------LQEERDKLITEMDRSLLEN- 1562
Query: 1473 VPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQ 1532
SLSSSC +S L+ G + L+++ + +L+ + A E LQ
Sbjct: 1563 -QSLSSSC--ESLKLALEGLTEDKEKLVKE------IESLKSSKIAESTEWQEKH-KELQ 1612
Query: 1533 EENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK---NKEIQELEQLLS 1589
+E ++ + E ++ + E RQ ++L K+ S K K++QE EQ +
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672
Query: 1590 SERQELDCLRK---QYLSENEQWQQKLTSVTLE--------MESKL---AAEKKQTEQLS 1635
++++ K Q + E E+ +L + ME+ L A+ K++ E++
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732
Query: 1636 LELEVARLQLQGLDLSSRSLLGIDTED---AIQGRNESCDISKEHTSETTERTPKHDVHQ 1692
+E E + Q L +S + L + +D I+G ++SK+ E TE KHD
Sbjct: 1733 MEYETLSKKFQSL-MSEKDSLSEEVQDLKHQIEG-----NVSKQANLEATE---KHD--- 1780
Query: 1693 ICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFS 1752
+ +TE G GE + S + P + S S
Sbjct: 1781 ------------NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE---------SVPSAK 1819
Query: 1753 GPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH 1812
N V DF + E N L+ + +++R +E + KE L
Sbjct: 1820 SANPAVSKDFSSHDE------------INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867
Query: 1813 LQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV----ETSEGLNS 1868
++ L+++I GELK +++ K+ + QE L RV ET+E
Sbjct: 1868 NEKNTLLSQIST------KDGELKMLQEEVT-KMNLLNQQIQEELSRVTKLKETAEEEKD 1920
Query: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
DLE E + + +A++N S DV + A I++E
Sbjct: 1921 DLE--------ERLMNQLAELNGSIGNYCQDVTD---------AQIKNE----------- 1952
Query: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
LE + +N +K + LEEE + E+ ++ E+ KE
Sbjct: 1953 -----LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI----------------RKEYL 1991
Query: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
++++ Q E ++ KE ELL+ +V +L KD QEK+ +LE+ +AL
Sbjct: 1992 EKIQGAQKE-----PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046
Query: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALR-- 2106
+ E + + + V+ + QA L + ++ L EAA V L+
Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAEL--ASFKVLLDDTQSEAARVLADNLKLKKE 2104
Query: 2107 LSSTQEEV-HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
L S +E V Q+++ E L R+E E+K L +E ++++K++ L RE
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHL----------KEKKNMQEKLDALRREKVH 2154
Query: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225
EE + + EV+ L+ ++ L F + +L+ +++ +
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV---------- 2204
Query: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
+ E K F ++ KE+ EI++KE++ +L++QL++++ + L + ++
Sbjct: 2205 IDEAKKWERKFSDAIQSKEE-EIRLKEDN---CSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
+Q + + E QL+ +K+ L+ + K+ +L QL+E+ H + + LE EL
Sbjct: 2261 KQIWESKAQTEVQLQ---QKVCDTLQGENKE---LLSQLEETRHLYHSSQNELAKLESEL 2314
Query: 2346 EIAR---TNQEHAALEAENSKGEVETL----KAKIEGMTQSLRGLELDVVTIRSEKENLT 2398
+ + T+ ++ + + KG +E + +A I+ S LE D+ R L
Sbjct: 2315 KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLH 2374
Query: 2399 NELQKEQERISEL-----EIIN--------------SSFENILQEKEQEKVQMKE----- 2434
E+ ++++I L E I EN+L ++E+E + ++E
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434
Query: 2435 --KSSTAMEMLQT----------QLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
K++ ME L+T QL + +++L ND++ Q L + + LEK
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494
Query: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS-KL 2541
QL+Q A+NN L+ + GL ++D + K D E+ + + +D Q+++ K
Sbjct: 2495 DQLIQEA-AAENN--KLKEEIRGLRSHMDDLNSENAKLDAELIQYR---EDLNQVITIKD 2548
Query: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTK 2601
SQ + ++ +QN EL N +LE+K++ + N L+ + LQ ++L E+E K
Sbjct: 2549 SQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK 2608
Query: 2602 MDKMSFVEKVNKMTAKETELQRE---------MHEMAQKTAELQEELSGEKNRLAGELQL 2652
+ ++++T + T LQ E + ++ L S + R+A +L
Sbjct: 2609 V-------SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA---EL 2658
Query: 2653 LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ--VEKEGKVREE-IAEYQLRLHEAEKK 2709
E + K+ K++ +LKK L +H D + E + EE +AE L E E+K
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLK-----SSKE---------- 2754
++ NK +IQ++ ++S + E+D LK S KE
Sbjct: 2719 -LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 2755 --ELNNSLKATTQILEELKKTKMDNLKYVNQ-----------LKKENERAQGKMKLLIKS 2801
E + L T + ++ + +L+ +NQ L + E + +++ K+
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837
Query: 2802 CKQLEEEKEILQKELSQLQAAQE-KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860
L+ E++ L EL + + ++E KQ++ T E++ LK+ + + D
Sbjct: 2838 MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTS----PAEVQSLKKAMSSLQNDRDRL 2893
Query: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
L + +L + ++ + L A L Q K
Sbjct: 2894 LKELKNLQQQYLQINQEITELHPLKAQLQEYQDK 2927
Score = 300 bits (768), Expect = 1e-80
Identities = 561/2826 (19%), Positives = 1158/2826 (40%), Gaps = 396/2826 (14%)
Query: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
++++KAQ + + E +L H+K E ++++EK K +L EKE++++
Sbjct: 111 IEEMKAQGGTVLPTEPQSEEQLSKHDKSST-------EEEMEIEKIKHKLQEKEELISTL 163
Query: 340 RDELVRTTAQYD-QASTK---YTALEQKLKKLTEDLSC-QRQNAES-ARCSLEQKIKEKE 393
+ +L + A+ Q+ST+ + ++Q+L++ E +S Q Q +++ A + +Q ++EK+
Sbjct: 164 QAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD 223
Query: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
F+ ++ + L + ++ + Q+L+ + + L V L+ L
Sbjct: 224 ARFETQVRLHEDELLQLVTQA-DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE----VCHLEAEL 509
+Q+ Q Q + + N LR ++E ++E+ +L E + E +L+ E+
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342
Query: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
++ + Q+ E++++ ++ E + K +E + + L+ +L+ D
Sbjct: 343 HHLLEQFEQAGQAQAELESRYSALEQ-----KHKAEMEEKTSHILSLQKTGQELQSACDA 397
Query: 570 SQD----LLKKREHH-------IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTL 618
+D LL+ + I+QL D+L + KE L+ L L++ E +T
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE----TASQTS 453
Query: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVE 678
F +E + +T E +LQ ++ LE + S E E L+ + E LS +
Sbjct: 454 FPDVYNEGTQAVT--EENIASLQKRVVELENEKGALLLSSIELEE----LKAENEKLSSQ 507
Query: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAEFS-------------DQKHQKEIENMCLKT 725
I L + + E +++ +++ K S QKH KE+ + L+
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKH-KELSVLLLEM 566
Query: 726 SQLTGQVEDLEHKLQ-----LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
+ ++ L+ +LQ +E++D+ Q E E + + K K T +D
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ---MEGEGIAPI-KMKVFLEDTGQDF 622
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-LQNRVDSLEFSL 839
P M + +++ + S + R + S ++ + L++ + SL
Sbjct: 623 ----------PLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSL 672
Query: 840 ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE--------- 890
+ + Q + E L E+E N KA+++++ + E ++ IS L +
Sbjct: 673 SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA 732
Query: 891 -DTSAHQNVVAETLSALENKEKELQLLND---KVETEQAEIQELKKSNHL-LEDSLKELQ 945
+ S+ ++E L ++ KEL ++ + +V+ + + E ++ L E
Sbjct: 733 DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
Query: 946 LLSE---TLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
LL+E +LS+E K I + + E++++ + + SL + N + A
Sbjct: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Query: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
+ + ELS Q++L + + + D+ + +EK+ ++ T
Sbjct: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV-------TE 905
Query: 1063 LCENRKNELEQLKE------AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS---E 1113
+ + ++ QL E K +E L L+ AEE + + E V L+ E
Sbjct: 906 ISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 1114 MTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND-LLQENEQLMKVMKTKHECQNLESE 1172
M+ SK E L+ E LK+E + ++++ L+ E L +V + + E NL+ E
Sbjct: 966 MSPAGQISKEE---LQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022
Query: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRN----KELKLQESE 1228
+ + E+ER + + D E KE S ++ ++E L+ KE++LQ
Sbjct: 1023 S-KKEIPLSETERGEV----EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIR 1077
Query: 1229 K---EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQND 1285
K EK + + Q + + + LQD +Q L EI + I +T +D
Sbjct: 1078 KDLEEKLAAEEQFQALVKQMNQT-LQDKTNQ--IDLLQAEISENQAIIQKLITSNTDASD 1134
Query: 1286 NAHLQCSLQTTM----------NKLNELEKICEILQAEKYELVTELNDSRSECITATRKM 1335
+ +T + + ELE+ L+ EK +L +L ++ + +K
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
Query: 1336 AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGE-FGEQPNEQHPVSLAPLDESNSYEHLT 1394
E+ L E+K DD L + E E G+Q + + ES + +
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ----IQVRESIDGKLPS 1250
Query: 1395 LSDKEVQMHFAELQEKFLSLQSEHK---ILHDQHC-------------QMSSKMSELQTY 1438
+E L+E +H +L C Q + +++++
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQ 1310
Query: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQ-----------LGLEEGLVPSLSSSCVPDSSSL 1487
+ ++AE + L + + +L K+ + GLE + ++S + SL
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370
Query: 1488 SS-LGDSSFYRALLEQTGDMS-LLSNLEGAVSANQCSVDEVFCS-SLQEENLTRKETPSA 1544
L S A LE ++ L L+ +S + V + S +E LT+ +T
Sbjct: 1371 QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE-- 1428
Query: 1545 PAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLS 1604
+ E E L ++ L ++E Q ++ I++L+ L +Q+ + + ++ +
Sbjct: 1429 ----IIEQEDL-------IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL-EVARLQLQGLDLSSRSLLGIDTEDA 1663
+ +Q Q+KL + + + L K E+LSL + RL D+ S+ +D
Sbjct: 1478 K-QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 1664 IQGRNESCDISKEHTSETTERT--PKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
+ GR ++ +R+ + C+ L L +E +TE K E
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCES-----LKLALEGLTEDKE-KLVKEI 1590
Query: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
+S ++K + EL Q++ L + SN
Sbjct: 1591 ESLKSSKIAESTEWQEKHK-------EL----------------QKEYEILLQSYENVSN 1627
Query: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSD 1841
E R+ HV VE++ E +EL KL E E EK + E ++E +
Sbjct: 1628 EAERIQHV-------VEAVRQEKQELYGKLRSTEANKK-------ETEKQLQEAEQEMEE 1673
Query: 1842 LSEKLEYFS-CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDV 1900
+ EK+ F+ Q++L+ E ++ L + E+H + ++ + + N S KE V
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRA--EVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 1901 ENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEK----DN------ENKQ 1943
+ E + SEK S+ E L+ +E +++ LE DN E Q
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
Query: 1944 KVIVCLEEELSVVTSER---------------------------NQLRGELDTMSKKTTA 1976
+ EE+ S+ S R N ++D + ++
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
Query: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK---EKTELLQTLSSDVSELLKDKTHL 2033
L++ +K KE +Q LE+ ++ L I + E+K E+ + L+ + E L T L
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
Query: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNK--------------EKELLVKESESLQARL 2079
+E + + D + L NQ+A+LN + ELL E ++L+ +
Sbjct: 1912 KETAEEEKDDLEE------RLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCV 1965
Query: 2080 SESDYEK-------LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
SE + EK V + +EK + A + + +L+ +++ + ++ +
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
Query: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE 2192
K + EK+ ER +L+ +++L++++EN + + ++AE+ + K ++
Sbjct: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 2193 EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE 2252
+ D + L+ E ++ + ++ + Q E + LE+ E+ ++ K+
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE------DLERRLEQAEEKHLKEKK 2139
Query: 2253 ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
+ ++ L+ + L E + + + +L+ +E QL+ +++ +L A
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEI----------QVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA-RTNQEHAALEAENSKGEVETLKA 2371
K + + D + + ER+ A ++ +E L+ +N LK
Sbjct: 2190 FTKS-------MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS----VLKD 2238
Query: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL-EIINSSFENILQEKEQEKV 2430
++ M+ + L++++ + +K+ ++ Q E + ++ + + + +L + E+ +
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETR- 2297
Query: 2431 QMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLD 2490
+ S + L+++LK L +++ L N E CK ++ NL + E + +
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD-------IQ 2350
Query: 2491 EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL 2550
+K +Y L++ + + +++ K+++I L + ++ Q+ ++++ +H
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA--IAELRQQHD- 2407
Query: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
++ EL NL + E++ VL+ +N D L + K ++ E K SFV+
Sbjct: 2408 --KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465
Query: 2611 VNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
++ + + + ++ ++ + E A E L EEI+ + + +L E
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
N++L L + RE++ + +K+ + L NK+ E + E
Sbjct: 2526 NAKLDAELI-----------QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
Query: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK-------YVNQ 2783
KL EE + + L+ K++L+ +++ + +L + ++ L+ Y Q
Sbjct: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR-QVTALQEEGTLGLYHAQ 2633
Query: 2784 LKKENERAQGKMKLLIKSCK---QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
LK + E L S K +LEEE +QKE + +K G + D+L
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--------KKVGEI----EDKLK 2681
Query: 2841 TEIKELKE---TLEEKTKEADEYLDKYCSLLISHEK----LEKAKEMLETQVAHL-CSQQ 2892
E+K L + +T+ A+E + + L+ E+ + K + L Q+ S
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 2893 SKQDSR 2898
S Q+SR
Sbjct: 2742 SLQNSR 2747
Score = 265 bits (678), Expect = 4e-70
Identities = 557/2827 (19%), Positives = 1133/2827 (40%), Gaps = 382/2827 (13%)
Query: 26 QLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES----LEK 81
+L++LK E ++ Q+ LEA Q + + + E +E + + N+R ES LE
Sbjct: 493 ELEELKAENEKLSSQITLLEA--QNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550
Query: 82 TKQKISHELQV-----KESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
T + EL V KE+Q +L K+ E+ + E+ K + +
Sbjct: 551 TFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK 610
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK----K 192
+ + +T Q P S + K + E ++ EE +A V+ K K
Sbjct: 611 MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
+ +P H+D S + L N + + + + +E+
Sbjct: 671 SLSAVPDIGQCHQDELERLKSQIL----------ELELNFHKA--QEIYEKNLDEKAKEI 718
Query: 253 TPSRSTLQIGKRDA--NSSFFDNSSSPH--LLDQLKAQNQ--ELRNKINELELRLQGHEK 306
+ ++ K++A NSS F S LL Q+K + ELR ++ +LE+ L E+
Sbjct: 719 SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778
Query: 307 EMK----GQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ 362
+ + Q L Q+ +E K+ + ++EL Q+ + ST +L+
Sbjct: 779 QRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQS 838
Query: 363 KLKKLTEDL--SCQRQNAESARCS-LEQKIKEKEKEF----------QEELSRQQRSFQT 409
+L+ ++ +R S++ L Q + +KE E + ++ Q++ +
Sbjct: 839 QLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE 898
Query: 410 LDQECIQMKARLTQELQQAKNMH-------NVLQAELDKLTSVKQQLENNLEEFKQKLCR 462
DQ+ ++ +T+++ Q L+ +L+ L+ ++ + +EE +
Sbjct: 899 KDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSG 958
Query: 463 AEQAFQ----ASQIKENELRRSMEEMKKENNLLKS-------HSEQKAREVCHLEAELKN 511
+Q + A QI + EL+ + +KKEN K + ++ + V LE EL N
Sbjct: 959 LKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN 1018
Query: 512 IKQ------CLNQSQN--FAEEMKAKNTSQETMLRDLQE-----KINQQENSLTLEKLKL 558
+K L++++ E+ + K S++ + QE K E + L+ ++
Sbjct: 1019 LKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK 1078
Query: 559 AVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE--------SKALLSALELKKKEYE 610
+ + + Q L+K+ ++ +++ + E K + S + +
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
Query: 611 ELKEEKTLFS--C------WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
L +E + S C WK E E+ + +E EKE LQ K+ T K K+ E
Sbjct: 1139 ALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE-- 1196
Query: 663 ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET--QKLAYMELQQKAEFSDQKHQKEIEN 720
+ R L + + + L D +S E E +L +++Q + + + +
Sbjct: 1197 -KERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 721 MCLKTSQLTGQVEDL--EHKLQ--LLSNEIMDKDRCYQDLHA-----EYESLRDLLKSKD 771
C T L + +H Q L SN D +D A ++ LK +
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 772 ASLV---------TNEDHQRSLLAFDQQPAMHHSFANI-----IGEQGSMPSERSECRLE 817
A V T+E ++S F Q ++ I + + + +E + +LE
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 818 ADQSP----KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEE----LVQIKGEI--EENL 867
+ Q ++ LQ ++D L+ + +++ S L Q E L +I+ EI +E+L
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 868 MKAEQMHQSFVA-ETSQRISKLQ--------------EDTSAHQNVVAETLSALENKE-- 910
+KA A E +RI +LQ E++ A Q + + +AL +++
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 911 -KELQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQLLSETLSLEKKEMSSIISLN 965
KE + L +++ + I+ L KS +E + KE + L+L ++E +I+
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 966 KREIEE---LTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK 1022
R + E L+ +LK L ++K L+++ ES + E + ++E
Sbjct: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY 1615
Query: 1023 LILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEH 1082
ILLQ E N E + +A +++ +L L + N+K +QL+EA +E
Sbjct: 1616 EILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA---NKKETEKQLQEA-EQEM 1671
Query: 1083 QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK-------SEAGGLKQEIMTL 1135
+E K+ + Q +LELE LR+E+ + +K S +K+E+ +
Sbjct: 1672 EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 1136 KEEQNKMQKEVNDLLQENEQLMK-VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM 1194
K E + K+ L+ E + L + V KH+ + S+ + +++ E NQ N
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK--QANLEATEKHDNQTN----- 1784
Query: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQ 1254
V E S + + +++ + ES + + D + + +
Sbjct: 1785 ---VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN---PAVSKDFSSHDEINNY 1838
Query: 1255 SQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314
Q+I LK+ EE+ T +N+ L + T +L L++ + K
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE-----EVTK 1893
Query: 1315 YELVTELNDSRSECITATRKMAEEVG-----KLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
L+ + +T ++ AEE +L+N++ LN G ++ + E
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
Query: 1370 --GEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQM-----------------HFAELQEK 1410
E N + VS ++ + T + E++ H ELQE
Sbjct: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 1411 FLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE 1470
Q E K L + K+S L+ V +L+ Q + K++++ +E
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEF-----------VQTESQKDLEI-TKE 2061
Query: 1471 GLVPSLS--SSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528
L ++ + +S L D + A ++ L L+ + + + +
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ--- 2118
Query: 1529 SSLQEENLTRK--ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM---KNKEIQE 1583
++E+L R+ + K + ++ + R+ LEE + + K+KE+Q+
Sbjct: 2119 ---KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 1584 LEQLLSSERQELDCLRK----------QYLSENEQWQQKLTSVTLEMESKLAAE------ 1627
L++ L S +L K + + E ++W++K + E ++ +
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV 2235
Query: 1628 -KKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI----SKEHTSETT 1682
K Q Q+S+ +E ++ + L+ + + + +Q + + CD +KE S+
Sbjct: 2236 LKDQLRQMSIHMEELKINISRLE-HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE 2294
Query: 1683 ERTPKHDVHQICD------------KDAQQDLNLDIEKITET-----GAVKPTGECSGEQ 1725
E +H H + KD DL+ +EK E G ++ + + Q
Sbjct: 2295 ET--RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQ--QEADIQ 2350
Query: 1726 SPDTNYEPPGEDKTQGSSECISELS-------------FSGPNALVPMDF--LGNQED-- 1768
+ +YE D Q S E S L SG + + L Q D
Sbjct: 2351 NSKFSYEQLETD-LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIEL 1828
I L+ + + EN+ V+E+ ++K N++ E + + +Q ++++ +
Sbjct: 2410 IKELENLLSQEEEENI----VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFV-- 2463
Query: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAK 1888
K S L + D+Q+L +R L+ LE ++ + A
Sbjct: 2464 --------KSMSSLQNDRDRIVGDYQQLEER-----HLSIILE-------KDQLIQEAAA 2503
Query: 1889 VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT-----EKLCLE---KDNE 1940
N+ KE + + + + SE A ++ E + DL V T +K LE + N+
Sbjct: 2504 ENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK 2563
Query: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK----EKTQELESHQS 1996
+ LEE+L LR + + ++ L + E +K + T+++ + Q
Sbjct: 2564 ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Query: 1997 ECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCELE 2055
E + + A++K K E + LS+ S K L+E+L ++K++ + + + +L+
Sbjct: 2624 E--GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLK 2681
Query: 2056 NQIAQLNKEKELLVKESESLQARLSE-------SDYEKLNVSKALEAALVEKGEFALRLS 2108
++ L+ + ++ E+E+ + R++E + + L V+K + + F +S
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK-LKERERE----------NDSLKDKVE 2157
S Q +++L+ + +A K+ + E+ L RER+ N + ++ +
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS 2801
Query: 2158 NLER-ELQMSEENQELVILDA--ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
+LE+ Q+ ++++L+ L + E+S +V++ + + +L R +E
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861
Query: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAA 2274
+ + +E+ L + SL ++++ ++K + +++ Q ++ EL+ A
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ-EITELHPLKAQ 2920
Query: 2275 LCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLL 2334
L Q+ KA + + +E ++ + +LR + E + + +Q + D
Sbjct: 2921 LQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQ 2980
Query: 2335 KGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK 2394
++NL REL + + + L+ + + A +G + EL +R++
Sbjct: 2981 LSHLQNLIRELRSSSSQTQ--PLKVQYQRQASPETSASPDGSQNLVYETEL----LRTQL 3034
Query: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERV 2454
+ E+ +++ RI +L NS+F +L+EK +Q+ + S + E Q +L
Sbjct: 3035 NDSLKEIHQKELRIQQL---NSNFSQLLEEKNTLSIQLCDTSQSLREN-QQHYGDLLNHC 3090
Query: 2455 AALHNDQEACKAKEQNL----SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510
A L + +A N+ + E + + + L E + ++ Q + QEV
Sbjct: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV 3150
Query: 2511 EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQ 2570
+ ++ LE++ ++ +N + E+ + +L EH W + EQ +
Sbjct: 3151 NELRKLLEEERDQRVAAENALSVAEEQIRRL-----EHSEWDSSRTPIIGSCGTQEQALL 3205
Query: 2571 VLQSKNA 2577
+ + N+
Sbjct: 3206 IDLTSNS 3212
Score = 241 bits (614), Expect = 1e-62
Identities = 464/2187 (21%), Positives = 910/2187 (41%), Gaps = 292/2187 (13%)
Query: 890 EDTSAHQNVVAETLSALENKEKELQ-LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLS 948
E + Q V E L+ E EL+ ++ K Q + + L++ ++ +K+L+L +
Sbjct: 41 EFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA 100
Query: 949 ETLSLEKKEMSSIISLNKREIEELTQENGT-----------LKEINASLNQEKMNLIQKS 997
+ + + SLNK IEE+ + GT L + + S +E+M +
Sbjct: 101 K---------AKLTSLNKY-IEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI---- 146
Query: 998 ESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLL 1057
E + + E+E+ IS L Q Q + ++ ++ E+ + QEK + L
Sbjct: 147 EKIKHKLQEKEELISTLQAQLTQAQA---EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ 203
Query: 1058 NECTSLCENRKNELEQLKEAFAKEHQ-EFLTKLAFAEERNQNLMLELET---VQQALRSE 1113
+ + + + EQ + +E F T++ E+ L+ + + +QQ LR
Sbjct: 204 AQLS------QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL 257
Query: 1114 MTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEP 1173
+ + +S G + +++ L +++ ++ N +L + Q M+ E
Sbjct: 258 QRKLEEHEESLVG--RAQVVDLLQQELTAAEQRNQILSQQLQQMEA----------EHNT 305
Query: 1174 IRNSVKERESERNQCNFK-PQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKE 1232
+RN+V E+ER + +M+LEV E L +N Q + + ++ ++E E
Sbjct: 306 LRNTV---ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESR 362
Query: 1233 CLQHELQTIRGDLE--TSNLQDMQS--QEISGLKDCEIDAEEKYISGPHELST-SQNDNA 1287
E Q + ++E TS++ +Q QE+ D D K + +E + S
Sbjct: 363 YSALE-QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ 421
Query: 1288 HLQCSLQTTMNKLNELEKICEILQAEKYELVTELN--DSRSECITATRKMAEEVGKLLNE 1345
L+ LQ K E+ + L +++E ++ + D +E A + E + L
Sbjct: 422 QLEDQLQ---QKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE--ENIASLQKR 476
Query: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFA 1405
V L ++ G L L+ I E + NE+ + L+ N E+ +
Sbjct: 477 VVELENEKGAL---LLSSIELEELKAE-NEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 1406 ELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV---- 1461
+ + +S +L + Q ++S L + + E L L+ + +
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV 592
Query: 1462 ---KEMQLGLEEGLVPSLSSSCVPDSSSLSSL--GDSSFYRALLEQTGDMSLLSNLEGAV 1516
KEM+ EG+ P + D+ L + S A+ ++ S +
Sbjct: 593 LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI 652
Query: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQ---SLEKLEEKMESQ 1573
S N V+ S+ Q+ + + P +ELE L + + K +E E
Sbjct: 653 SLNDAGVE--LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN 710
Query: 1574 GIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVT-LEMESKLAAEKKQTE 1632
K KEI L QL+ ++ D + + +E+ Q L+ V L M ++L A+ KQ E
Sbjct: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLE 770
Query: 1633 ----------QLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQG-RNESCDISKEHTSET 1681
+L E + A L + S S+ + I+ +NE D+ + + ++
Sbjct: 771 MNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQS 830
Query: 1682 T------ERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPT-----GECSGEQSPDTN 1730
T + + + + + ++ +E++++ + K + E+ D
Sbjct: 831 TLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
Query: 1731 -YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
+ E+K Q ++E+SFS +V ++ E+ +L + +K T E L LL
Sbjct: 891 TLQQTIEEKDQQ----VTEISFSMTEKMVQLN-----EEKFSLGVEIK-TLKEQLNLLSR 940
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF 1849
E+ ++ NE+ K + E+ +I EL+ LKKEN KL+
Sbjct: 941 AEEAKKEQVEEDNEVSS-GLKQNYDEMSPAGQISK-EELQHEFDLLKKENEQRKRKLQAA 998
Query: 1850 SCDHQELLQRVETSEGLNSDL------EMHADKSSREDIGDNVAKVNDSWKERFL----- 1898
+ +ELLQRV E ++L E+ ++ R ++ ++ K N + E+ +
Sbjct: 999 LINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED--KENKEYSEKCVTSKCQ 1056
Query: 1899 DVENELSRIRSEK-ASIEHEALYLEADLEVVQTEKLCLEKDNE---NKQKVIVCLEEELS 1954
++E L + SEK ++H LE L + + +++ N+ +K I L+ E+S
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
Query: 1955 --------VVTSERNQLRGELDTMSKKTTALD------------QLSEKMKEKTQELESH 1994
++TS + G+ + K+T + +L EK+ +E E
Sbjct: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQL 1176
Query: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL 2054
Q + + +A +K+ E + L ++ + D LQE+ K+++ +
Sbjct: 1177 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG------ 1230
Query: 2055 ENQIAQLNKEKELLVKESESLQARLSESDY-EKLNVSKALEAALVEKGE----------- 2102
++ ++L ++ ES+ +L +D E + + LE L + E
Sbjct: 1231 -------DQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN 1283
Query: 2103 FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE 2162
S E+ L+ G +++ + E + + +LK ++ K E + +
Sbjct: 1284 LCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
Query: 2163 LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQE 2221
Q++++ E+ L + +AEV Q + + L++ L+ L L+ + + L K I +
Sbjct: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
Query: 2222 KQ-------GQLSELDKLLSSFKSLLEEKE--------QAEIQIKEESKTAVEMLQNQL- 2265
K+ GQLSE + L+ ++ + E+E Q E+Q KE + ++ LQ +L
Sbjct: 1404 KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER-IKQLQVELC 1462
Query: 2266 ------KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLC 2319
+E+ E A Q ++A S ++E L+ + R +E K
Sbjct: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLAD 1522
Query: 2320 VLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS 2379
V Q+ D + GR+ L+ E + T + + LE ++ E+LK +EG+T+
Sbjct: 1523 VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTED 1582
Query: 2380 LRGLELDVVTIRSEKENLTNELQ-KEQERISELEIINSSFENILQEKEQ-----EKV-QM 2432
L ++ +++S K + E Q K +E E EI+ S+EN+ E E+ E V Q
Sbjct: 1583 KEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQE 1642
Query: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL--SSQVECLELE------KAQ 2484
K++ + + KE +++ + E K K + S Q + LELE +A+
Sbjct: 1643 KQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAE 1702
Query: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS-Q 2543
+ D AK L SS + +E+E K + E ++ L ++ + V L Q
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 2544 VEGEHQLWKEQNLEL-------RNLTVELEQKIQVLQSKNASL-QDTLEVLQSSYKNLEN 2595
+EG + K+ NLE N+T E Q I + SL T S + ++
Sbjct: 1763 IEG--NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKS 1820
Query: 2596 ELELTKMDKMSFVEKVNKMTAKETELQRE---MHEMAQKTAELQEELSGEKNRLAGELQL 2652
D S +++N + +L+ + E QK E + L EKN L ++
Sbjct: 1821 ANPAVSKD-FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST 1879
Query: 2653 LLEEIKSSKDQLKELTLENSELKKSLDCM---------HKDQVEKE-----GKVREEIAE 2698
E+K ++++ ++ L N ++++ L + KD +E+ ++ I
Sbjct: 1880 KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
Query: 2699 YQLRLHEAEKKHQALLLDTN--KQYEVEIQTYREKLTSKEECLSSQ--KLEIDLLKSSKE 2754
Y + +A+ K++ L + K+ E++ +++L ++ + S+ K ++ ++ +++
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 2755 ELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQK 2814
E N K+ + L+EL K K +K QL+K+ R Q K+ L ++ K LE + QK
Sbjct: 2000 EPGN--KSHAKELQELLKEKQQEVK---QLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 2815 EL-----SQLQAAQEKQKTGTVM--------DTKVD---------ELTTEIKELKETLEE 2852
+L + QA + ++K + DT+ + +L E++ KE+++
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 2853 KTKEADEYLDKYCSLLISHEKLEKAKE 2879
+ K+ DE L++ +LE+A+E
Sbjct: 2115 QMKQKDEDLER---------RLEQAEE 2132
Score = 198 bits (503), Expect = 8e-50
Identities = 399/1976 (20%), Positives = 797/1976 (40%), Gaps = 302/1976 (15%)
Query: 12 LPTRALQKIQELEGQLDKLKKEKQQRQ-------FQLDSLEAALQK-QKQKVENE---KT 60
L L+ ++EL+ +LD+L+K +++ QL EAAL K Q + +E E K
Sbjct: 1379 LQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKA 1438
Query: 61 EGTNL--------KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK---K 109
T L +R Q +E+CE +K ++I E + K+ + L S K K
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQK-PEEIGEESRAKQQIQRKLQAALISRKEALK 1497
Query: 110 QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE 169
+ + L++EL + +ER ++ + ++ N + L L+E
Sbjct: 1498 ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL-----------LQE 1546
Query: 170 KYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS 229
+ +K + E R E ++L + S L + + + + S + K
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTE 1603
Query: 230 SNSQRTPIRRDFS---ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQ 286
+ +++++ SY + E + ++ +++ + S+ + + Q
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Query: 287 NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC------- 339
QE ++ E++ +++ K K + K EL+ + ++ + E+ +C
Sbjct: 1664 LQEAEQEMEEMKEKMR---KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 340 ----RDELVRTTAQYDQASTKYTALEQKLKKLTE---DLSCQRQNAESARCSLEQKIKEK 392
++EL R +Y+ S K+ +L + L+E DL Q + S + +LE K
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780
Query: 393 EKEFQEELSRQQRSFQTLDQECIQMKARLT--QELQQAKNMHNVLQAEL---DKLTSVKQ 447
+ E Q +T +Q+ + M R T + + AK+ + + + D++ + Q
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 448 QLEN------NLEEFKQKLCRAEQAFQ------ASQI--KENELRRSMEEMKKENNLLKS 493
Q++ LEE KQK Q + SQI K+ EL+ EE+ K N L +
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 494 HSEQKAR----------EVCHLEAELKNIKQCLNQS-QNFAEEM---KAKNTSQETMLRD 539
E+ +R E LE L N LN S N+ +++ + KN E+ +++
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 540 LQE---KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKK--REHHIEQLNDKLSKTEKE 594
L++ ++ +++ L EK K+ ++ + Q K+ + H ++L + L + ++E
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
K L +++ L+ ++E++K +E KENL + H K
Sbjct: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQK---DLEITKENLAQAVEH----RKKA 2073
Query: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ-KLAYMELQQKAEFSDQK 713
Q + + + + + + + L L S V++Q K +L+++ E +++K
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 714 HQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
H KE +NM K L + LE + + + KD+ Q L +S L + S
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
+ + +D + ++ D+ F++ I S+ E RL+ D N ++L++++
Sbjct: 2194 MSSLQDDRDRVI--DEAKKWERKFSDAI------QSKEEEIRLKED----NCSVLKDQLR 2241
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
+ +E K +N + +++ + K + E L +++ + E + +S+L+E
Sbjct: 2242 QMSIHMEELK-INISRLEHDKQIWESKAQTEVQLQ--QKVCDTLQGENKELLSQLEET-- 2296
Query: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
+++ + + L E EL+ L D++ +++ K+ LE +++ + +
Sbjct: 2297 --RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354
Query: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISE 1013
+++ + + ++ L +E ++ SL K IQ + A + +K I E
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ--VAIAELRQQHDKEIKE 2412
Query: 1014 LSD---QYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
L + Q ++E ++L + ++ + L + K +++N + + L+ + +N+
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
Query: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
++ ++Q+ EER+ +++LE + + Q +E N K E GL+
Sbjct: 2473 ----RDRIVGDYQQL-------EERHLSIILEKDQLIQEAAAE----NNKLKEEIRGLRS 2517
Query: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190
+ L E K+ E L+Q E L +V+ K Q E KE E++ +
Sbjct: 2518 HMDDLNSENAKLDAE---LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
Query: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TS 1248
K + E E S+NA LQE EK+ L E+++++ + T
Sbjct: 2575 KLKESEEANEDLRRSFNA---------------LQE---EKQDLSKEIESLKVSISQLTR 2616
Query: 1249 NLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICE 1308
+ +Q + GL ++ +E+ + H LS ++ ++ ELE+
Sbjct: 2617 QVTALQEEGTLGLYHAQLKVKEEEV---HRLS----------ALFSSSQKRIAELEEELV 2663
Query: 1309 ILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGE 1368
+Q E A +K+ E KL E+K L+ D+G++ E
Sbjct: 2664 CVQKE-----------------AAKKVGEIEDKLKKELKHLHHDAGIMRNE--------- 2697
Query: 1369 FGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428
+ E+ LA E+++K L + E+K L Q
Sbjct: 2698 --TETAEERVAELA-------------------RDLVEMEQKLLMVTKENKGLTAQIQSF 2736
Query: 1429 SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSS-SL 1487
MS LQ D E L R + L KE+ E+GL+ + + +++ S+
Sbjct: 2737 GRSMSSLQNSRDHANEE---LDELKRKYDASL-KELAQLKEQGLLNRERDALLSETAFSM 2792
Query: 1488 SSLGDSSF-------YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKE 1540
+S ++S + L + + L S LE S NQ +SLQ E
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED--SYNQVQSFSKAMASLQNER----- 2845
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
+ L + E +R+S E+ +++ +Q E+Q L++ +SS + + D L K
Sbjct: 2846 ---------DHLWNELEKFRKS-EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
+ + +Q+ Q +T K ++ Q + + ++ L+
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELR---------------- 2939
Query: 1661 EDAIQGRNESCDISKEHTS-ETTERTPKHD-VHQICDKDAQQD--LNLDIEKITETGAVK 1716
++ + ++E + E +S E ER K + I DKD Q NL E + + +
Sbjct: 2940 QENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQ 2999
Query: 1717 PTG-ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1775
P + + SP+T+ P G +E L+ + ++IH +LR
Sbjct: 3000 PLKVQYQRQASPETSASPDGSQNLVYETE------------LLRTQLNDSLKEIHQKELR 3047
Query: 1776 VKETSNENLRLL--------------HVIEDRDRKVESLLNEMKELDSKL-HLQEVQLMT 1820
+++ ++ +LL + + + LLN L+ ++ LQ L
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
Query: 1821 KIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
+ EK K + +L E + FS Q+L + L LE D+
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQ 3163
Score = 124 bits (312), Expect = 1e-27
Identities = 225/1088 (20%), Positives = 452/1088 (41%), Gaps = 119/1088 (10%)
Query: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV----ENEKT 60
LE E + L++ + ++ +LD L++EK + + ++ L K+ ++V EN +
Sbjct: 2123 LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182
Query: 61 EGTNLKRENQRLM-------EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK 113
T L + + + + +K ++K S +Q KE ++ +E + K Q+ +
Sbjct: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
Query: 114 LE---QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK 170
+ +ELK S LE +Q +S + QK+ T L S+ E+ +
Sbjct: 2243 MSIHMEELKINISRLEHDKQIWESK--AQTEVQLQQKVCDT-LQGENKELLSQLEETRHL 2299
Query: 171 YNKEVEERKRLEAEVKAL--QAKKASQTLPQATM---NHRDIARHQAS---SSVFSWQQE 222
Y+ E +LE+E+K+L Q S +L + N I R Q + +S FS++Q
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359
Query: 223 KTPSHLSSN-----SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSP 277
+T S + ++ S SG++E + D +N S
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419
Query: 278 HLLDQ--LKAQNQELRNKINELELRLQGHEKE---MKGQVNKFQELQLQLEKAKVELIEK 332
+ L+ +N++ +K N+L L+ +KE K Q++ F + L+ + ++
Sbjct: 2420 EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGD 2479
Query: 333 EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
+ L + ++ + DQ + A KLK+ L + S L+ ++ +
Sbjct: 2480 YQQLEERHLSII---LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 393 EKEFQEELS-RQQRSFQTLDQECIQMK------ARLTQELQQAKNMHNVLQAELDKLTSV 445
++ + ++ + + Q L+ + Q K A+L ++L++++ + L+ + L
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 446 KQQLENNLEEFK---QKLCRAEQAFQAS----------QIKENELRR-------SMEEMK 485
KQ L +E K +L R A Q ++KE E+ R S + +
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA 2656
Query: 486 KENNLLKSHSEQKAREVCHLEAEL-KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
+ L ++ A++V +E +L K +K + + E + + RDL E
Sbjct: 2657 ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM- 2715
Query: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE- 603
+Q+ + ++ K A ++ L R+H E+L++ K + K L E
Sbjct: 2716 -EQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
Query: 604 -LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK---INHLETCLKTQQIKSH 659
L +E + L E T FS S E L+ +E + L SK + HL + L+ +
Sbjct: 2775 GLLNRERDALLSE-TAFS-MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ 2832
Query: 660 EYNERVRTLEMDRENLSVEIRNLHNVLDSKS----------VEVETQKLAYMELQQKAEF 709
+++ + +L+ +R++L E+ + K EV++ K A LQ +
Sbjct: 2833 SFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRD- 2891
Query: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQ----DLHAEYESLRD 765
+ KE++N+ + Q+ ++ +L H L+ E DK + +Q +L E S +
Sbjct: 2892 ---RLLKELKNLQQQYLQINQEITEL-HPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH 2947
Query: 766 LLKSKDASLVTNEDHQRS-----LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
L + E H+R L+A + N+I E S S+ +++ +
Sbjct: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR 3007
Query: 821 --SPKNSAILQNRVDSLEFSLESQKQMNSDLQK--QCEELVQIKGEIEENLMKAEQMHQS 876
SP+ SA + + + + Q+N L++ Q E +Q L++ +
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067
Query: 877 FVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHL 936
+ +TSQ + + Q+ H + + LE + +ELQ ++ QE K H
Sbjct: 3068 QLCDTSQSLRENQQ----HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNGVHR 3122
Query: 937 LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL------TQENGTLKEINASLNQEK 990
D +EL+ ++ S ++++ + ++E+ EL ++ E S+ +E+
Sbjct: 3123 KSDP-EELREPQQSFSEAQQQLCN----TRQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177
Query: 991 MNLIQKSE 998
+ ++ SE
Sbjct: 3178 IRRLEHSE 3185
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 286 bits (731), Expect = 3e-76
Identities = 630/3026 (20%), Positives = 1243/3026 (41%), Gaps = 471/3026 (15%)
Query: 174 EVEERKRLEAEVKALQAKKASQTLPQ--ATMNHRDIARHQASSSVFSWQQEKTPS----- 226
E+EE R E++ + Q L + A + RD Q ++++ ++EK +
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
Query: 227 HLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
L+ SQ+ I+ + AS + + + L K+ + HLL+ +
Sbjct: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
Query: 286 QNQELRNKINELELRLQGHEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCR 340
+ ++ +I+ L+ +++ +E E +V + QE + +E+ ++IE+EK + +
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
Query: 341 DELVRTTAQYDQASTKYTALEQKLK----KLTEDLSCQRQNAESAR---CSLEQKIKEKE 393
D+L + + Q++K +LT +RQ++E + ++E+ K
Sbjct: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
Query: 394 KEFQEELSRQQRSFQTLDQECIQMKARL-----TQELQQAKNMHNVLQAELDKL-TSVKQ 447
K+ Q E QR Q ++ Q++A L Q +Q + + A+++++ T K
Sbjct: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
Query: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
++EN L + +Q + + NEL +++ + LK E C L+
Sbjct: 470 EMENALRSYSNITVNEDQ-IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQ 566
+L+++ + L+ S+ + + QE+ K+N+ SL T+E LK + +
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQES-------KLNEAHKSLSTVEDLKAEIVSASES 581
Query: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSE 625
R ++L K E + KL EKE A+L + E ++ E E L+ + LFS + E
Sbjct: 582 R---KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ-LLFS-HEEE 636
Query: 626 NEKLLTQMESE-KENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNL 682
KL +E E + N++ ++L K QQI +E ++++ T++ +++NL + L
Sbjct: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
Query: 683 -----------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
++++SKS E+ Q ELQ++ E Q+ +++ L +
Sbjct: 696 ILEISKLKDLQQSLVNSKSEEMTLQ---INELQKEIEILRQEEKEK--------GTLEQE 744
Query: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
V++L+ K +LL ++ +K+ Q+ A+ E+ +LK + +L ED + Q+
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEE 801
Query: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMN 846
+ + + S+ + E +E ++ K I ++ + ++ F+ ++ +
Sbjct: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-----QRIS----KLQEDT-SAHQ 896
+LQ++ L+++K ++E++ K E ++S + + QRI+ K++ +
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELK----------KSNH----LLEDSLK 942
VAETL E EK+ L +K+E + E EL K H L + +K
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK 981
Query: 943 ELQLLSETLSLEKKEMSSIISLNKRE---------------IEELTQE--NGTLKEINAS 985
L+ E +SL +E+ II+ N+ E + +T G++ ++N S
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKS 1041
Query: 986 LNQEKMNLIQKSESFANYI----DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQ 1041
+E +++ SF N ++E+ I + +E + + E ++L+
Sbjct: 1042 FGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
Query: 1042 KYKAAQEKNSKLE----CL-------LNECTSLCENRKNE-LEQLKE--AFAKE------ 1081
+ ++E CL +++ EN K++ L LKE FA+E
Sbjct: 1102 LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKEL 1161
Query: 1082 ---HQEFLTKLAFAE--ERNQNLMLELETVQQALRSEMT--------------------- 1115
HQ L + E + + L L + +Q+A+ E +
Sbjct: 1162 QKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCE 1221
Query: 1116 ----DNQN-------NSKSEAGGLKQEIMTLKEEQ----NKMQKEVNDLLQENEQLMKV- 1159
D +N N E + E+ +E NK+ +E N LL +L K+
Sbjct: 1222 VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIW 1281
Query: 1160 ------MKTKHECQNL---ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
MK + +NL E+E + + E N K ++ ++++ Q+
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLS-SLQDLEKTKLEEQV 1340
Query: 1211 VQLEAMLRNKELKLQESEKEKE----CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
+LE+++ + + +L+E+E+ E CLQ LQ + S S + + E
Sbjct: 1341 QELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV------SESTVPPSLPVDSVVITES 1394
Query: 1267 DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE---------- 1316
DA+ G +N + ++ S + + + + K+ E E+ E
Sbjct: 1395 DAQRTMYPGS---CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSM 1451
Query: 1317 -----LVTELND-SRSECITATRKMAEEVGK----LLNEVKILNDDSGLLHGELVEDIPG 1366
TEL+ S + TA+ K A V + NE+K+ D G E V+
Sbjct: 1452 SIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFK 1511
Query: 1367 GEFGEQPNE--QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424
EF E +H + SNS H K+ + + E+ S +
Sbjct: 1512 EEFKPLSKELGEHGKEIL---LSNSDPHDIPESKDCVL---TISEEMFSKDKTFIVRQSI 1565
Query: 1425 HCQMSSKMSELQTYVDSLKAENLVL--STNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP 1482
H ++S V S+ A ++ L + + +LV++ Q
Sbjct: 1566 HDEIS---------VSSMDASRQLMLNEEQLEDMRQELVRQYQ----------------- 1599
Query: 1483 DSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS---ANQCSVDEVFCSSLQEENLTRK 1539
+ + L + R + Q D L ++ A + S+D S + E + +
Sbjct: 1600 EHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVS-ERERVLLE 1658
Query: 1540 ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE----------QLLS 1589
E + + E LC R S + + E+QG ++ + +E E ++LS
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILS 1718
Query: 1590 SERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLD 1649
+ER L ++ +L + LE+ AA +E + R L LD
Sbjct: 1719 NERYAL-----------QKANNRLLKILLEVVKTTAA---------VEETIGRHVLGILD 1758
Query: 1650 LSSR--SLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIE 1707
SS+ S + + +SC + +EHT T E P + + + D+N+
Sbjct: 1759 RSSKSQSSASLIWRSEAEASVKSC-VHEEHTRVTDESIPSYSGSDM----PRNDINM-WS 1812
Query: 1708 KITETGA-----VKPTGECSGEQSPDT-----NYEPPGEDKTQGSSECISELSFSGPNAL 1757
K+TE G + +G E P+ N + + E ISE S +A
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK 1872
Query: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDR----DRKVESLLNEMKELDSKLH- 1812
V Q ++ R K+ + E+L+ + +R R E L E+ + + +
Sbjct: 1873 V------TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDG 1926
Query: 1813 ------LQEVQLMTKIEACIELEK-------IVGELKKENSDLSEKLEYFSCD------- 1852
L E Q+ K + LE+ + EL+ E + E+ E S
Sbjct: 1927 YADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE 1986
Query: 1853 ----HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVE---- 1901
Q+LLQ E +++ A+K R+D+ V + +E RF+++E
Sbjct: 1987 AGPVEQQLLQETEKLMKEKLEVQCQAEK-VRDDLQKQVKALEIDVEEQVSRFIELEQEKN 2045
Query: 1902 NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961
EL +R + ++E + LE + + + + E + + Q+ I LE++L VV R
Sbjct: 2046 TELMDLRQQNQALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVV--PRF 2100
Query: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021
Q E +T ++QL+ +KEKT + SE L + + +++E+ E ++ L
Sbjct: 2101 QPISE-----HQTREVEQLANHLKEKTDKC----SELLLSKEQLQRDIQERNEEIEKLEF 2151
Query: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL--LVKESESLQARL 2079
V EL + K + LSL + A KEKE+ L ++ E + L
Sbjct: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Query: 2080 SESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI---EADEKKQL 2136
+ E + LE ++K E RL ++E + +EKL + I +A +
Sbjct: 2212 ENKNEEVQQLHMQLE---IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2268
Query: 2137 HI-----AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
H+ A+ ++E+E E D L ++V L+++L+++ +N+ + E + L+TQI
Sbjct: 2269 HVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI-----EEKNELIRDLETQI 2323
Query: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKSLLEE----KEQA 2246
E + + + + E E L + I++ Q +L+ + K + SL EE K Q
Sbjct: 2324 ECLMSDQECVKRN---REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQL 2380
Query: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
++ I E+ L+ Q++ NE + + + ++K T ++ +E L+ E +
Sbjct: 2381 DVVIAEKL-----ALEQQVETANEEMTFM---KNVLKETNFKMNQLTQELFSLKRERESV 2432
Query: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
E + L + + +++ E+ + LE NQ + EN KG +
Sbjct: 2433 EKIQSIPENSVNVAIDHLSKDKPELEVV--LTEDALKSLE----NQTYFKSFEENGKGSI 2486
Query: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
L+ ++ + ++ +L++ + +++ + Q E E + + +I+N LQ+
Sbjct: 2487 INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK-KIVN------LQKIV 2539
Query: 2427 QEKVQMKEKSSTAMEMLQTQLK--ELNERVAA---LHNDQEACKAKEQNLSSQVECLELE 2481
+EKV S +E +Q K + N+ +++ N Q + +E L S + L L
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2599
Query: 2482 KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL----------EKKDEEISRLKNQI 2531
++L + E + I+ + V + V + ++KL EKK E + K
Sbjct: 2600 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK-KRSP 2658
Query: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLE-LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY 2590
QD E L + + LE LR +V + ++ + K LQ+ L V +++
Sbjct: 2659 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNM 2718
Query: 2591 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE-KNRLAGE 2649
+L+ +L + D ++ ++ + KE E + + + A L +LS ++ G
Sbjct: 2719 TSLQKDLSQVR-DHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2777
Query: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709
L++ SS +Q ++ ++N+ ++ +L + +V E I+++ ++ + ++
Sbjct: 2778 LKI------SSSNQTPQILVKNAGIQINLQSECSSE-----EVTEIISQFTEKIEKMQEL 2826
Query: 2710 HQALLLDTNKQYEVEIQTYREK-----LTSKEECLSSQKLEIDLLKSSK-----EELNNS 2759
H A +LD ++ E +T + + KEEC + K I L+S + E ++
Sbjct: 2827 HAAEILDMESRHISETETLKREHYVAVQLLKEEC-GTLKAVIQCLRSKEGSSIPELAHSD 2885
Query: 2760 LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL 2819
T +I + Y+ + + ++G+ ++ E + K++ L
Sbjct: 2886 AYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGR-------GEESESATDSFPKKIKGL 2938
Query: 2820 QAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL--LISHEKLEKA 2877
A + + T+ E +++ E +E Y++ SL LI+ +L++
Sbjct: 2939 LRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE 2998
Query: 2878 KEMLETQVAHLCSQQSKQDSRGSPLL 2903
E+ ++ +H +S D RG LL
Sbjct: 2999 AEVYDSSQSH----ESFSDWRGELLL 3020
Score = 260 bits (665), Expect = 1e-68
Identities = 553/2734 (20%), Positives = 1126/2734 (41%), Gaps = 455/2734 (16%)
Query: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL-TQELQQA 428
D S Q A+ + LE + EL+ +Q + L++E +M+ T+ LQQ
Sbjct: 142 DDSYSEQGAQDSPTHLEM--------MESELAGKQHEIEELNRELEEMRVTYGTEGLQQL 193
Query: 429 KNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488
+ +A + + + QL NL++ +++ + F + +L+ ++++
Sbjct: 194 QEF----EAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE 249
Query: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
L S A ++ + ++ +Q L + + E+ + K + LQEKI E
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Query: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
+E+ K K + +++ ++++E IE+LN K+ + EK++ L L K
Sbjct: 310 ----MEQDK-------KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 609 YEELKEEKTLFSCWKSENEKL-LTQMESEKENLQSKINHLETCLKTQQIKSHE----YNE 663
EL +E+ + + +N KL LT + ++ +I L ++ Q ++H+ +
Sbjct: 359 LGEL-QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 664 RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCL 723
V+ +E + + ++R + + + + Q+L + Q E +H+ E+EN
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK-TRHKGEMENALR 476
Query: 724 KTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD----LLKSKDA------S 773
S +T E +++L++ I + + QD +++ E L++ +L+ K A
Sbjct: 477 SYSNITVN----EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED 532
Query: 774 LV-----TNEDHQRSLLAFDQQPA----MHHSFA---NIIGEQGSMPSERSECRLEADQS 821
LV + E QR+ +Q + H S + ++ E S R E L+ +
Sbjct: 533 LVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAE 592
Query: 822 PKN------------SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE-ENLM 868
N +A+L +S E LE + L EEL ++K ++E E+ +
Sbjct: 593 VTNYKIKLEMLEKEKNAVLDRMAESQEAELE--RLRTQLLFSHEEELSKLKEDLEIEHRI 650
Query: 869 KAEQMHQSFVAETSQRISKLQEDTS--------------AHQNVVAETLSALENKEKELQ 914
E++ + Q+I LQ + S QN + +S L K+ +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL--KDLQQS 708
Query: 915 LLNDKVETEQAEIQELKKSNHL----------LEDSLKELQLLSETLSLEKKEMSSIISL 964
L+N K E +I EL+K + LE ++ELQL +E L + KE + +
Sbjct: 709 LVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL-- 766
Query: 965 NKREIEELTQENGTLKE----------INASLNQEKMNLIQ---KSESFANYIDEREKSI 1011
+ + +L EN LK+ I+ ++QE+ + KS+S + ++ + +
Sbjct: 767 -QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 1012 SELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA-AQEKNSKLECLLNECTSLCENR-KN 1069
E ++ KQ+ + L + E+ N + + ++ QE + CLL L +++ K
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
Query: 1070 ELEQLKEAFAKEHQEFLTKL----------AFAEERN-QNLMLELETVQQALRSEMTDNQ 1118
ELE + A + L ++ F E++ LE+ V + +E+ +
Sbjct: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
Query: 1119 NNSKSEAGGLKQEIMTLKEEQNK-------MQKEVNDLLQENEQL------MKVMKTKHE 1165
+K E L Q + L E+ + + +EV L QE EQ+ ++++ +
Sbjct: 946 EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 1166 CQNLES--------------------EPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
+N++S E + V + E ++ + ++ E + +S
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 1206 YNAQLVQLEAMLRNKELKLQESE-KEKECLQHELQTIRGDLETSNLQDMQSQEI--SGLK 1262
QL+ KE L+ ++ E + LQ EL ++ + LQ M++Q I S +
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ-MEAQRICLSLVY 1124
Query: 1263 DCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
+D +Y+ +N+ CSL+ + E EKI E+ + + EL T
Sbjct: 1125 STHVDQVREYM---------ENEKDKALCSLKEELIFAQE-EKIKELQKIHQLELQTMKT 1174
Query: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
+ + + +GKL K ++++ L + GE +
Sbjct: 1175 QETGD---EGKPLHLLIGKL---QKAVSEECSYFLQTLCSVL-----GEYYTPALKCEVN 1223
Query: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSL 1442
D+ NS ++++ ++ ELQ+ +Q + +H +++ + ++L
Sbjct: 1224 AEDKENSGDYISENED------PELQDYRYEVQDFQENMHTLLNKVTEEYNKL------- 1270
Query: 1443 KAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQ 1502
LVL T L G M+L E +P + + S +++L D
Sbjct: 1271 ----LVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDI--------- 1317
Query: 1503 TGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS 1562
D++ S L SSLQ+ T+ E + V+ELESL +Q
Sbjct: 1318 --DVNHKSKL----------------SSLQDLEKTKLE------EQVQELESLISSLQQQ 1353
Query: 1563 LEKLEEKMESQGIMKNKEIQELEQ--------LLSSERQELDCLRKQYLSENEQWQQKLT 1614
L++ E+ E++ K +Q + + + S E D R Y +K
Sbjct: 1354 LKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG---SCVKKNI 1410
Query: 1615 SVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
T+E + K++T + L + + QL+ + ++ ++ + A Q
Sbjct: 1411 DGTIEFSGEFGV-KEETNIVKLLEKQYQEQLE--EEVAKVIVSMSIAFAQQTELSRISGG 1467
Query: 1675 KEHTSETTERTPKHDVHQICDKDAQ--QDLNLDIEKI----TETGAV------KPTGECS 1722
KE+T+ + + H +C ++ ++ L ++I ET V KP +
Sbjct: 1468 KENTASSKQ------AHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 1723 GEQSPD---TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL----QLR 1775
GE + +N +P +++ ISE FS + + ++ + ++ QL
Sbjct: 1522 GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 1776 VKETSNENLR--LLHVIEDRDRKVESLLN-EMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
+ E E++R L+ ++ + E L M++++ + QE QL +I+ ++
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRL--NRQLA 1638
Query: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND- 1891
+N +L + E + E L+++ + E+ + ++ +N +V +
Sbjct: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
Query: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV-CLE 1950
++KE+ LD + E + E++ E+ L+K N K+++ ++
Sbjct: 1699 TFKEKELDRKPE------------------DVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
+V + + G LD SK ++ + E E+ C+H E +
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWR------SEAEASVKSCVH-----EEHTR 1789
Query: 2011 EKTELLQTLS-SDV--------SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
E + + S SD+ S++ ++ T L ++L + T+ + EN+
Sbjct: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV-----RSGFAGTEIDPENE---- 1840
Query: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
EL++ S LQA + + S LE A V + E ++E + +
Sbjct: 1841 ----ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
Query: 2122 EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE---ENQELVILDAE 2178
E+LR R+ + + + +A +L + E D D+ ER++Q + E +L A
Sbjct: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
Query: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD-KLLSSFK 2237
N E+E + QI+E E+E L++Q + + + ++ +LL +
Sbjct: 1957 NRLQELEAEQQQIQE-----------------ERELLSRQKEAMKAEAGPVEQQLLQETE 1999
Query: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
L++EK ++++ +++ + LQ Q+K L V E+ + IE E
Sbjct: 2000 KLMKEK----LEVQCQAEKVRDDLQKQVKALEIDV-------------EEQVSRFIELEQ 2042
Query: 2298 QLRNSIEKLRARLEADEKK----QLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
+ + LR + +A EK+ + + +Q + EH D+ + ++ LE++L++ Q
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
Query: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE- 2412
+E+ EVE L ++ T L L ++ + + E++K + R+ ELE
Sbjct: 2103 ----ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Query: 2413 ---IINSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
+ + ++ K + ++++ + A++ + ++ L E++ + E +
Sbjct: 2159 ALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEV 2218
Query: 2469 QNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLK 2528
Q L Q+E + E LQ L++ + +D +KL +E +
Sbjct: 2219 QQLHMQLEIQKKESTTRLQELEQENKLF--------------KDDMEKLGLAIKESDAMS 2264
Query: 2529 NQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKI------QVLQSKNASLQDT 2582
QDQ L K +Q+ E ++ +Q L +L+Q++ +V++ KN ++D
Sbjct: 2265 T--QDQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRD- 2318
Query: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE 2642
L++ + L ++ E K ++ +E++N++ K LQ+E+ + QKT+ LS E
Sbjct: 2319 ---LETQIECLMSDQECVKRNREEEIEQLNEVIEK---LQQELANIGQKTSMNAHSLSEE 2372
Query: 2643 KNRLAGELQLLL--------------EEIKSSKDQLKELTLENSELKKSLDCM--HKDQV 2686
+ L +L +++ EE+ K+ LKE + ++L + L + ++ V
Sbjct: 2373 ADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2432
Query: 2687 EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE----CLSSQ 2742
EK + E + +K ++L + +E QTY + + L ++
Sbjct: 2433 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETR 2492
Query: 2743 KLEIDLLKSSKE-ELNNSLKATTQILEELK-KTKMDNLKYVNQLKKENERAQGKMKLLIK 2800
L+++ S+K+ EL K + E+ + +T+M K VN K E K+ +
Sbjct: 2493 LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE----KVAAALV 2548
Query: 2801 SCKQLEEEKEILQ--KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2858
S QLE +E + ++ + + E+ + + DEL ++I L + E +
Sbjct: 2549 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQV- 2607
Query: 2859 EYLDKYCSLLISHEK--------LEKAKEMLETQ 2884
++ + SL++ E+ LEK K++LE Q
Sbjct: 2608 --VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ 2639
Score = 248 bits (632), Expect = 9e-65
Identities = 644/3293 (19%), Positives = 1315/3293 (39%), Gaps = 604/3293 (18%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ----KQKQKVENEKTEGTNLKRENQRLM 73
Q+++E + L+ +K+K+ Q+ L+ ++ +Q +KVEN E +E + ++
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI---QEKETII 331
Query: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
E + ++K + EL+ K + + G+L ++QI + QE+K K EL S+Q +
Sbjct: 332 EELNTKIIEEEKKTLELKDKLTTADKLLGEL---QEQIVQKNQEIKNMKLELTNSKQKER 388
Query: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE-DLKEKYNKEVEER-KRLEAEVKALQAK 191
+ + Q + T + + S++E D+ ++ +E + + ++L AE+ + +
Sbjct: 389 QSSEEIK-----QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQ 443
Query: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQE---KTPSHLSSNSQRTPIRRDFSASYFSG 248
+ Q + H +A+ + + + E ++ S+++ N + +
Sbjct: 444 QIVQMKQELIRQH--MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIK 501
Query: 249 EQEVTPSRSTL--QIG---------KRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Q+ + L ++G +R + S S + + + E +K+NE
Sbjct: 502 LQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA 561
Query: 298 ELRLQGHEKEMKGQVNKFQELQLQLE----------KAKVELIEKEKVLNKCRDELVRTT 347
L E ++K ++ E + +LE K K+E++EKEK N D + +
Sbjct: 562 HKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQ 618
Query: 348 -AQYDQASTKYT-ALEQKLKKLTEDLSCQ-RQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
A+ ++ T+ + E++L KL EDL + R N E + +L K++ Q E+S++
Sbjct: 619 EAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678
Query: 405 RSFQTLDQECIQMKARLTQELQQAKNMH-NVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
+ Q I + +L E+ + K++ +++ ++ +++T +L+ +E +Q+
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEK 738
Query: 464 ---EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL---- 516
EQ Q Q+K L + M+E KEN+L + ++ +A E L+ E K ++ L
Sbjct: 739 GTLEQEVQELQLKTELLEKQMKE--KENDLQEKFAQLEA-ENSILKDEKKTLEDMLKIHT 795
Query: 517 --NQSQN--FAEEMKAKNTSQ------ETMLRD----------LQEKINQQENSLTLEKL 556
+Q + F + +K+K+ E ++ + L E+I +Q N+ + +
Sbjct: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855
Query: 557 KLAV--ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL------------ 602
V +L+++ C LLK ++ L D +K E E K+ L AL
Sbjct: 856 NFEVNYQELQEEYAC---LLKVKD----DLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 603 --ELKKKEYEELK----EEKTLFSCWKSENEKLLTQME---SEKENLQSKINHLETCLKT 653
++K ++E K E + + + +L+ ++E EK L +++ L LK
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
Query: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
+ + NE V++L+ ++E +S+ R L +++ E + D +
Sbjct: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAE-------------NVQSCDTQ 1015
Query: 714 HQKEIENMCLKTSQ-LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772
++ + TS+ G V + S +++ ++++ ES ++ L
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 773 SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD-QSPKNSAILQNR 831
VT E R+ QP+ + E + SE+++ RL+ + Q S +
Sbjct: 1076 PSVTKESSLRAT-----QPSENDKLQK---ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA--ETSQR----- 884
VD + +E++K + L EEL+ + E + L K Q+ + ET
Sbjct: 1128 VDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
Query: 885 --ISKLQEDTSAHQNVVAETLSAL---------------ENKEKELQLLNDKVETE---- 923
I KLQ+ S + +TL ++ E+KE +++ + E
Sbjct: 1186 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 924 QAEIQELKKSNHLLEDSLKE------------------------LQLLSETLSLEKKEMS 959
+ E+Q+ +++ H L + + E L+ E L E+ E
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 960 SIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK 1019
SI S +E++ + + ++++ + EK L ++ + + I ++ + E Y+
Sbjct: 1306 SIHS-QMTNLEDIDVNHKS--KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYE 1362
Query: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
E L +R + + S + S + + + + +N +E E
Sbjct: 1363 AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGV 1422
Query: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
KE + L E+ LE E + + + Q S G K+ + K+
Sbjct: 1423 KEETNIVKLL----EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
Query: 1140 NKMQKE---VNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195
Q+E N++ +Q+ + +T E +P+ + E E N P
Sbjct: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
Query: 1196 LEVKE----ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ 1251
E K+ IS + ++ + + E+ + + ++ + +E Q L+
Sbjct: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ----------LE 1588
Query: 1252 DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICE--I 1309
DM+ + + ++ + E + ++ + D LQ ++ +L + I +
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648
Query: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
+ + L+ EL + + K+ E+ + + N++ G ++ F
Sbjct: 1649 VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--------EVEEQTF 1700
Query: 1370 GEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS 1429
E+ ++ P + P SN L ++ + E+ + +++ S
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 1430 SKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP------- 1482
SK + + +AE V S V E + + +PS S S +P
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSC---------VHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 1483 -----DSSSLSS-LGDSSFYRALLEQTGD---MSLLSNLEGAV---------SANQCSVD 1524
+ + LS L S F ++ + +++ S L+ AV +++Q
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 1525 EVFCSSLQEENLTRKETPSAPAKGVEEL-ESLCEVYRQSLEKLEEKMESQGIMKN----- 1578
+V + L E+ +K+ + K EEL E L E R + E +++G++
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931
Query: 1579 ----KEIQELEQLLSSERQELDCL--RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTE 1632
++IQE ++ QEL C R Q L +Q Q+ + + + AE E
Sbjct: 1932 TLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE 1991
Query: 1633 QLSLELEVARLQLQGLDLSSRS------------LLGIDTEDAI--------QGRNESCD 1672
Q L+ E +L + L++ ++ L ID E+ + + E D
Sbjct: 1992 QQLLQ-ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 1673 ISKEHTS--ETTERTPKHDVHQICDKDAQQDL-NLDIEKITETGAVKPTGECSGEQSPDT 1729
+ +++ + + E+ K Q D++ ++D+ +I+K+ + V P + E
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQT-R 2109
Query: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + + +C SEL S + D E+I L+ RV+E L
Sbjct: 2110 EVEQLANHLKEKTDKC-SELLLSKEQ--LQRDIQERNEEIEKLEFRVRELEQALL----- 2161
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQ-EVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
+EDR +++K L EVQL + +A EK + L+++ E+LE
Sbjct: 2162 VEDR--------KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2213
Query: 1849 FSCDHQEL--------------LQRVETSEGL-NSDLEM------HADKSSRED------ 1881
+ + Q+L LQ +E L D+E +D S +D
Sbjct: 2214 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2273
Query: 1882 -----IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY--LEADLEVVQTEKLC 1934
I + ++ D E+ ++ +L K E L LE +E + +++ C
Sbjct: 2274 KFAQIIQEKEVEI-DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2332
Query: 1935 LEKDNENK----QKVIVCLEEELSVV-----------TSERNQLRGELDTMSKKTTALDQ 1979
++++ E + +VI L++EL+ + + E + L+ +LD + + AL+Q
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392
Query: 1980 LSE------------------KMKEKTQELES--HQSECLHCIQ-VAEAEV--------K 2010
E KM + TQEL S + E + IQ + E V K
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2452
Query: 2011 EKTELLQTLSSDVSELLKDKTH--------------LQEKLQSLEKDSQA--LSLTKC-- 2052
+K EL L+ D + L+++T+ L+ +L LE A L LT+C
Sbjct: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2512
Query: 2053 ELENQIAQLNKEKELLVKESESLQARLSE-----------------------------SD 2083
++++ Q E E+L K+ +LQ + E S+
Sbjct: 2513 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2572
Query: 2084 YEKLNVSKALEAALVEKGE----FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
E+ N+ + E G LR+S + +V ++ + + ++E EK L
Sbjct: 2573 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2632
Query: 2140 EKL------------KERERENDSLKDKVENLERELQMSEENQE------LVILDAEN-- 2179
+KL K+RE+E VE L+ ++ N+E L L AE+
Sbjct: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692
Query: 2180 SKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK-----LLS 2234
+KAE+ + K + E++ L V E ++ +L+ + + + E + +LS L+K +
Sbjct: 2693 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752
Query: 2235 SFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE 2294
S K+ + E ++ S+T + + + + + G Q I +E S + E
Sbjct: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ-INLQSECSSEEVTE 2811
Query: 2295 EEHQLRNSIEKLRARLEAD----EKKQLCVLQQLKESEHHA-DLLKGRVENLERELEIAR 2349
Q IEK++ A+ E + + + LK + A LLK L+ ++ R
Sbjct: 2812 IISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871
Query: 2350 TNQEHAALE----------------------------------------AENSKGEVETL 2369
+ + + E E S+ ++
Sbjct: 2872 SKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSF 2931
Query: 2370 KAKIEGMTQSLRGLELDVVTIR----SEKENLTNELQKE---QERISELEIINSSFENIL 2422
KI+G+ +++ + V+++ S+ E+ + + E +ER + + I+S + I
Sbjct: 2932 PKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLIT 2991
Query: 2423 QEKEQEKVQMKEKSST-----------AMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
+ + Q + ++ + S + + + Q L+E + +AA + A +
Sbjct: 2992 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA-- 3049
Query: 2472 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE------DGKQKLEKKDEEIS 2525
+ CLE + QG++ + ++ L+ E++ +G++ K+++E
Sbjct: 3050 VGLLNCLEQRIQE--QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE 3107
Query: 2526 RLKNQIQDQ--EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL 2583
+ ++ + +Q S++ +++ E K++ EL+ + + L+S+ A + L
Sbjct: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3167
Query: 2584 EV-LQSSYKNLENELELTKM---DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL 2639
E L++ +K+L+ ELE ++ DK V +N A E + K+ ELQ L
Sbjct: 3168 ETTLKAQHKHLK-ELEAFRLEVKDKTDEVHLLNDTLASEQK----------KSRELQWAL 3216
Query: 2640 SGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY 2699
EK +L + EE++ K L+ N +L L+ + E + K+ + Y
Sbjct: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276
Query: 2700 QLRLHEAEKKH---QALL-------------LDTNKQYEVEIQTYREKLTSKEECLSSQK 2743
+L E + ++ Q LL LD ++ ++Q+ S+ S
Sbjct: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-- 3334
Query: 2744 LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK 2803
DLLK +++L ++L E +K K+D+L ++ +
Sbjct: 3335 ---DLLKELQKQLEEKHSRIVELLNETEKYKLDSL---------------------QTRQ 3370
Query: 2804 QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Q+E+++++ +K L Q +Q+ T K+ EL +++++L+ LEEK ++
Sbjct: 3371 QMEKDRQVHRKTL------QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3417
Score = 245 bits (625), Expect = 6e-64
Identities = 648/3256 (19%), Positives = 1301/3256 (39%), Gaps = 562/3256 (17%)
Query: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKR- 67
KE + KI E E + +LK + L L+ + ++ Q+++N K E TN K+
Sbjct: 327 KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 68 ------ENQRLMEICESLEKTKQKISH-ELQVKESQVNFQEGQLNSGKKQIEKL-EQELK 119
E ++LM E L+K K S E + + + +L + +++++ Q++
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
+ K EL R A + E++K ++ E+E
Sbjct: 447 QMKQELIRQHMA-------------------------------QMEEMKTRHKGEMENAL 475
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-SNSQRTPIR 238
R + + + L +N +I +S Q+EK L ++ ++
Sbjct: 476 RSYSNI---TVNEDQIKLMNVAINELNIKLQDTNS-----QKEKLKEELGLILEEKCALQ 527
Query: 239 RDFSASYFSGEQEVTPSRSTLQIGKR---DANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
R +E++ SR +Q ++ + S + S ++ LKA+
Sbjct: 528 RQLEDLV----EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
Query: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT-TAQYDQAS 354
ELEL+ HE E+ K K+E++EKEK N D + + A+ ++
Sbjct: 584 ELELK---HEAEVTNY------------KIKLEMLEKEK--NAVLDRMAESQEAELERLR 626
Query: 355 TKYT-ALEQKLKKLTEDLSCQ-RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
T+ + E++L KL EDL + R N E + +L K++ Q E+S++ + Q
Sbjct: 627 TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD 686
Query: 413 ECIQMKARLTQELQQAKNM-HNVLQAELDKLTSVKQQLENNLEEFKQ---KLCRAEQAFQ 468
I + +L E+ + K++ +++ ++ +++T +L+ +E +Q + EQ Q
Sbjct: 687 NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 746
Query: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL------NQSQN- 521
Q+K L + M+E KEN+L + ++ +A E L+ E K ++ L +Q +
Sbjct: 747 ELQLKTELLEKQMKE--KENDLQEKFAQLEA-ENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 522 -FAEEMKAK----------------NTSQETMLRDLQEKINQQENSLTLEKLKLAV--AD 562
F + +K+K N + L E+I +Q N+ + + V +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL--------------ELKKKE 608
L+++ C LLK + + L D +K E E K+ L AL ++K
Sbjct: 864 LQEEYAC---LLKVK----DDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 609 YEELK----EEKTLFSCWKSENEKLLTQME---SEKENLQSKINHLETCLKTQQIKSHEY 661
++E K E + + + +L+ ++E EK L +++ L LK + +
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Query: 662 NERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENM 721
NE V++L+ ++E +S+ R L +++ E + D + ++ +
Sbjct: 977 NEEVKSLKQEKEQVSLRCRELEIIINHNRAE-------------NVQSCDTQVSSLLDGV 1023
Query: 722 CLKTSQ-LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
TS+ G V + S +++ ++++ ES ++ L VT E
Sbjct: 1024 VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS 1083
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD-QSPKNSAILQNRVDSLEFSL 839
R+ QP+ + E + SE+++ RL+ + Q S + VD + +
Sbjct: 1084 LRA-----TQPSENDKLQK---ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM 1135
Query: 840 ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV--AETSQR-------ISKLQE 890
E++K + L EEL+ + E + L K Q+ + ET I KLQ+
Sbjct: 1136 ENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQK 1193
Query: 891 DTSAHQNVVAETLSAL---------------ENKEKELQLLNDKVETE----QAEIQELK 931
S + +TL ++ E+KE +++ + E + E+Q+ +
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ 1253
Query: 932 KSNHLLEDSLKE------------------------LQLLSETLSLEKKEMSSIISLNKR 967
++ H L + + E L+ E L E+ E SI S
Sbjct: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS-QMT 1312
Query: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
+E++ + + ++++ + EK L ++ + + I ++ + E Y+ E L +
Sbjct: 1313 NLEDIDVNHKS--KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQK 1370
Query: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
R + + S + S + + + + +N +E E KE +
Sbjct: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVK 1430
Query: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE-- 1145
L E+ LE E + + + Q S G K+ + K+ Q+E
Sbjct: 1431 LL----EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQH 1486
Query: 1146 -VNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE--- 1200
N++ +Q+ + +T E +P+ + E E N P E K+
Sbjct: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
Query: 1201 -ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
IS + ++ + + E+ + + ++ + +E Q L+DM+ + +
Sbjct: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ----------LEDMRQELVR 1596
Query: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC--EILQAEKYEL 1317
++ + E + ++ + D LQ ++ +L + I ++ + L
Sbjct: 1597 QYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
Query: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377
+ EL + + K+ E+ + + N++ G ++ F E+ ++
Sbjct: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--------EVEEQTFKEKELDRK 1708
Query: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQT 1437
P + P SN L ++ + E+ + +++ SSK +
Sbjct: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
Query: 1438 YVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP------------DSS 1485
+ +AE V S V E + + +PS S S +P + +
Sbjct: 1769 LIWRSEAEASVKS---------CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819
Query: 1486 SLSS-LGDSSFYRALLEQTGD---MSLLSNLEGAV---------SANQCSVDEVFCSSLQ 1532
LS L S F ++ + +++ S L+ AV +++Q +V + L
Sbjct: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELM 1879
Query: 1533 EENLTRKETPSAPAKGVEEL-ESLCEVYRQSLEKLEEKMESQGIMK---------NKEIQ 1582
E+ +K+ + K EEL E L E R + E +++G++ ++IQ
Sbjct: 1880 RESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ 1939
Query: 1583 ELEQLLSSERQELDCL--RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEV 1640
E ++ QEL C R Q L +Q Q+ + + + AE EQ L+ E
Sbjct: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ-ET 1998
Query: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS-KEHTSETTERTPKHDVHQICDKDAQ 1699
+L + L++ ++ D +Q + ++ +I +E S E + + + +
Sbjct: 1999 EKLMKEKLEVQCQA---EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055
Query: 1700 QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVP 1759
Q L +EK+ + EQ+ D +E
Sbjct: 2056 QALEKQLEKMR---------KFLDEQAIDREHE--------------------------- 2079
Query: 1760 MDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD---SKLHLQEV 1816
D Q++I L+ ++K R + E + R+VE L N +KE S+L L +
Sbjct: 2080 RDVF--QQEIQKLEQQLKVVP----RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 1817 QLMTKI-EACIELEKIVGELKK-ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1874
QL I E E+EK+ +++ E + L E ++F VE L+ ++++ A
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGA--------VEAKPELSLEVQLQA 2185
Query: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC 1934
++ + D ++ ++E +L + R E + E L LE+ + E
Sbjct: 2186 ERDA-----------IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2234
Query: 1935 ----LEKDN----ENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMK 1985
LE++N ++ +K+ + ++E ++ T +++ L G+ + +K +DQL+E++
Sbjct: 2235 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2294
Query: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL-QEKLQSLEKDS 2044
+ Q+L+ I ++EK EL++ L + + L+ D+ + + + + +E+ +
Sbjct: 2295 KLQQQLK---------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLN 2345
Query: 2045 QALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA 2104
+ + + EL N + + L +E++SL+ +L EKL + + +E A E
Sbjct: 2346 EVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMK 2405
Query: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE---NLER 2161
L T +++QL + + L+ E+ EK Q I E ++ S KDK E L
Sbjct: 2406 NVLKETNFKMNQLTQELFSLKRERESVEKIQ-SIPENSVNVAIDHLS-KDKPELEVVLTE 2463
Query: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
+ S ENQ EN K + L+T++ ++ ++ +L+L + +++ +Q
Sbjct: 2464 DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ--- 2520
Query: 2222 KQGQLSELDKLLSSFKSLLEEKEQA----EIQIK-----------------EESKTAVEM 2260
Q + L K + + + ++EEK A +IQ++ E +T ++
Sbjct: 2521 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2580
Query: 2261 LQNQLK--ELNEAVAAL-CGDQEIMKATEQSLDPPIEEEHQL----RNSIEK------LR 2307
L NQL+ EL ++AL E+ + I E+ Q+ +N +EK L+
Sbjct: 2581 L-NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ 2639
Query: 2308 ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN--SKGE 2365
LE +EKKQ ++ K S ++LK E E N E AL AE+ +K E
Sbjct: 2640 KLLEGNEKKQR--EKEKKRSPQDVEVLKTTTELFHSNEESGFFN-ELEALRAESVATKAE 2696
Query: 2366 VETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEK 2425
+ + K K E + + L E ++ +++ + + + L + +E++S I+ E +QE
Sbjct: 2697 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS---ILEKEDETEVQES 2753
Query: 2426 EQ----EKVQMKEKSSTAMEMLQT-------QLKELNERVAALH-NDQEACKAKE-QNLS 2472
++ E + +K S A + T Q ++ + A + N Q C ++E +
Sbjct: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2813
Query: 2473 SQ-------------VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-- 2517
SQ E L++E + + + +Y+ +Q L++E E G K
Sbjct: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ-----LLKE-ECGTLKAVI 2867
Query: 2518 ----EKKDEEISRLKNQIQDQEQLVSK------------LSQVEGEHQLWKEQNLELRNL 2561
K+ I L + Q + + L+ +G + + E +
Sbjct: 2868 QCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2927
Query: 2562 TVELEQKIQ-VLQSKNASLQDTLEVLQSSYK-----NLENELELTKMDKMSFVEKVNKMT 2615
T +KI+ +L++ + L + +S Y +++ E ++ +++ ++ +
Sbjct: 2928 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK 2987
Query: 2616 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS---SKDQLKELTLENS 2672
T++Q + +++ E S + L LQ + E +S + + + L +
Sbjct: 2988 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT 3047
Query: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQL------------------------------- 2701
+ L+C+ E +++E+ EYQ
Sbjct: 3048 DAVGLLNCL-------EQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITL 3100
Query: 2702 -RLHEAEKKHQALLLDTNKQ-------YEVEIQTYREKLTSKEECLSSQKLEIDLLKS-- 2751
R E+EK Q LL +Q +VE+ + +++ T +E LSS+K+ + LKS
Sbjct: 3101 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3160
Query: 2752 --SKEELNNSLKATTQILEELK------KTKMDNLKYVNQ-LKKENERAQGKMKLLIKSC 2802
+K EL +LKA + L+EL+ K K D + +N L E ++++ L K
Sbjct: 3161 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3220
Query: 2803 KQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLD 2862
+L +E ++EL L+ + E QK + +L +++ K+ L E ++ +
Sbjct: 3221 AKLGRSEERDKEELEDLKFSLESQKQRNL------QLNLLLEQQKQLLNESQQKIESQRM 3274
Query: 2863 KYCSLLISHE----KLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTE 2918
Y + L + +L+ E + ++ + S ++ + L G S P +E
Sbjct: 3275 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3334
Query: 2919 KRLSSGQNKASGKRQR 2934
L Q + K R
Sbjct: 3335 DLLKELQKQLEEKHSR 3350
Score = 194 bits (494), Expect = 9e-49
Identities = 527/2879 (18%), Positives = 1158/2879 (40%), Gaps = 450/2879 (15%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77
+I L ++ LK+EK+Q + LE + + EN ++ T + ++ +
Sbjct: 972 EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR--AENVQSCDTQVSSLLDGVVTMTSR 1029
Query: 78 ----SLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE-RSQQA 131
S+ K + E ++ E +V+F+ + KQ + + L E R+ Q
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Query: 132 AQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
+++ + LN + Q + + Y ++ + +E K KAL
Sbjct: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD-----KALC 1144
Query: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQ---EKTPSHLSSNSQRTPIRRDFSASYF 246
+ K Q HQ Q+ E P HL + + + SYF
Sbjct: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYF 1202
Query: 247 S-------GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
GE + + ++ + + + P L Q+ R ++ + +
Sbjct: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL--------QDYRYEVQDFQE 1254
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
+ ++ + NK LQ +L K + + K L + L + ++ ++ T
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK-LEFGEENLPKEETEFLSIHSQMTN 1313
Query: 360 LEQ-------KLKKLTE----DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
LE KL L + L Q Q ES SL+Q++KE E+ ++ E+ Q+ Q
Sbjct: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 409 TLDQECIQMKAR-----LTQELQQA---------KNMHNVLQAE----LDKLTSVKQQLE 450
+ + + +T+ Q KN+ ++ + + T++ + LE
Sbjct: 1374 AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
Query: 451 NNLEE-FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
+E ++++ + + + ++ EL R KEN S ++A VC E
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTA----SSKQAHAVCQQEQHY 1487
Query: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
N + L+Q Q + + + + + L +++ + + L D+ + +DC
Sbjct: 1488 FN-EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD--PHDIPESKDC 1544
Query: 570 ----SQDLLKKREHHI--EQLNDKLSKTEKESKALLSALE-----LKKKEYEELKEEKTL 618
S+++ K + I + ++D++S + ++ L E ++++ + +E +
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
Query: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY----NERVRTLEMD--- 671
+ + + + + ++E LQ +I L L + +E ERV E++
Sbjct: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
Query: 672 ------RENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAE-----------FSD 711
RE L E+RN + + EVE Q EL +K E ++
Sbjct: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYAL 1724
Query: 712 QKHQKEIENMCLKTSQLTGQVEDL--EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
QK + + L+ + T VE+ H L +L + +E E+
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
Query: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER----SECRLEADQSPKNS 825
++ + VT+E + P + + + E+G+ S+R E D P+N
Sbjct: 1785 EEHTRVTDESIPS--YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID--PENE 1840
Query: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQR 884
++ N L+ ++E + S+ Q E + E+ E+ + ++ +S + R
Sbjct: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900
Query: 885 ISKLQEDTSAHQNVVAETLSA---LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+L E++ A + + E A ++ E L +++ + I L++ + L
Sbjct: 1901 -ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
+EL+ + + E++ +S K E + Q+ L + L +EK+ + ++E
Sbjct: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVR 2016
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
D+ +K + L +++ ++ +E DL Q+ +A +++ K+ L+E
Sbjct: 2017 ---DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
Query: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
+R++E + ++ K Q+ F + +++ E+E + L+ E TD +
Sbjct: 2074 I---DREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLK-EKTDKCSEL 2128
Query: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHECQ-NLESEPIRN 1176
L+++I EE K++ V +L Q E+ + ++ K E ++ + R+
Sbjct: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERD 2188
Query: 1177 SVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE--LKLQESEKEKECL 1234
++ +E E N + Q++ +E+ + Q + ++ ++ KE +LQE E+E +
Sbjct: 2189 AIDRKEKEIT--NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2246
Query: 1235 QHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ 1294
+ +++ + ++ S+ Q Q + K +I E++ E+ LQ L+
Sbjct: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV-----EIDQLNEQVTKLQQQLK 2301
Query: 1295 -TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353
TT NK+ E EK EL+ +L +++ EC+ + ++ + + E++ LN+
Sbjct: 2302 ITTDNKVIE----------EKNELIRDL-ETQIECLMSDQECVKRNRE--EEIEQLNEVI 2348
Query: 1354 GLLHGELVEDIPGGEFGEQPN-EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE---LQE 1409
L EL G++ + H +S +E++S +H ++ + AE L++
Sbjct: 2349 EKLQQELAN------IGQKTSMNAHSLS----EEADSLKH------QLDVVIAEKLALEQ 2392
Query: 1410 KFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLE 1469
+ + E + + + + KM++L + SLK E ++ Q + + ++
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIPENSVNVAID 2448
Query: 1470 EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS------NLEGAVSANQCSV 1523
V +L SL + +++++ E+ G S+++ LE VSA +
Sbjct: 2449 HLSKDKPELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLESTVSAKDLEL 2507
Query: 1524 DEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQE 1583
+ + + + ET K + L+ + E + L +++ + + + + +
Sbjct: 2508 TQCYKQIKDMQEQGQFETEMLQKK-IVNLQKIVE--EKVAAALVSQIQLEAVQEYAKFCQ 2564
Query: 1584 LEQLLSSERQELDCLRKQYLSENEQWQQ---------KLTSVTLEMESKLAAEKKQTEQL 1634
Q +SSE + + L E+E +L S +EM + L EK+Q E
Sbjct: 2565 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2624
Query: 1635 S---LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
LE E L+LQ L ++G K+ + +R+P+
Sbjct: 2625 EKNVLEKEKKLLELQKL---------------LEGNE------KKQREKEKKRSPQ---- 2659
Query: 1692 QICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISEL-S 1750
D+E + T + + E SG +EL +
Sbjct: 2660 -------------DVEVLKTTTELFHSNEESG---------------------FFNELEA 2685
Query: 1751 FSGPNALVPMDFLGNQEDIHNLQ--LRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808
+ + +E LQ L VKET+ +L+ + + + + + E
Sbjct: 2686 LRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ---------KDLSQVRDHLAEAK 2736
Query: 1809 SKLHLQEVQLMTKIE----AC------IELEKIV-----GELKKENSDLSEKLEYFS--- 1850
KL + E + T+++ AC I+L K + G LK +S+ + ++ +
Sbjct: 2737 EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2796
Query: 1851 -------CDHQELLQRV-ETSEGLNSDLEMHA----DKSSREDIGDNVAKVNDSWKERFL 1898
C +E+ + + + +E + E+HA D SR ++++ +E ++
Sbjct: 2797 QINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR-----HISETETLKREHYV 2851
Query: 1899 DVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952
V+ + KA I E ++ A + QT ++C + + I +
Sbjct: 2852 AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQ 2911
Query: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL------------H 2000
+ SE RGE + +A D +K+K + + + + L H
Sbjct: 2912 GFDIASEG---RGE-----ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2963
Query: 2001 CIQ-VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
IQ V+E ++E+ + T+SS + K + + ++ + ++ S + EL +
Sbjct: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3023
Query: 2060 QLN-KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSSTQE----- 2112
Q+ +E+ +L+ + L +D + + LE + E+G E+ + Q+
Sbjct: 3024 QVFLEERSVLLAAFRTELTALGTTD--AVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS 3081
Query: 2113 ---EVHQLRRGIEKLRVRIEADEKKQLHIAEKLK-----------ERERENDSLKDKVEN 2158
E+ L + ++ ++ +++ + E L+ E + E S+KD+
Sbjct: 3082 LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE 3141
Query: 2159 LERELQMSEENQELVILDAENSKAEVE---TLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
L+ Q+S E + L +E ++ ++E TLK Q + + + L+ F L++ E L
Sbjct: 3142 LQE--QLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLL 3198
Query: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN----EA 2271
+ +Q + EL L K+ L E+ + + E+ K ++E + + +LN +
Sbjct: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258
Query: 2272 VAALCGDQEIMKATEQSLDPPIEEEH------QLRNSIEKLRAR---LEADEKKQLCVLQ 2322
L Q+ +++ D + EE Q+ EK+R R D +++L
Sbjct: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318
Query: 2323 QLKESEHHA-------DLLKGRVENLE----RELEIARTNQEHAALEAENSKGEVE---- 2367
Q + + DLLK + LE R +E+ +++ L++ ++ ++E
Sbjct: 3319 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY-KLDSLQTRQQMEKDRQ 3377
Query: 2368 ----TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423
TL+ + E T+ + + ++S+ E+L +L+++++++ +L++ + I+Q
Sbjct: 3378 VHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3433
Query: 2424 EKEQEKVQMKEKSSTAMEMLQ---------------------------------TQLKEL 2450
E ++++++ +EK + + Q +L E+
Sbjct: 3434 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3493
Query: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510
N +++ E + K Q ++S+++ L + ++ LQ ++I +Q +++ +I ++
Sbjct: 3494 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL 3553
Query: 2511 EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQ 2570
+ + ++ +S + E+L+ + +++ G E+ +LRN+ ++LE++I+
Sbjct: 3554 QKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613
Query: 2571 VLQSKNASLQDTLEVLQSSYKNLE----NELELTKMDKMSFVEKVNKMTAKETELQREM 2625
+ A ++ + N+E +E E+ +K++ + + + A+ +L+ E+
Sbjct: 3614 WYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3672
Score = 152 bits (384), Expect = 5e-36
Identities = 281/1418 (19%), Positives = 604/1418 (42%), Gaps = 165/1418 (11%)
Query: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE- 1534
+ S+ +P+S+ + +L EQ + L S + + +A+ CS + CS +
Sbjct: 73 VESTVIPESTIMRTLHSGEITSH--EQGFSVELESEI--STTADDCSSEVNGCSFVMRTG 128
Query: 1535 ---NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591
NL R+E GV++ S E Q E MES+ K EI+EL + L
Sbjct: 129 KPTNLLREEE-----FGVDD--SYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLS 1651
R Q L E E ++ + ++ + L +++ ++ E Q Q L +
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 1652 SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD--KDAQQDLNLDIEKI 1709
+ L +T + + D+ + T + + + + + ++D + I +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
Query: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769
E V YE + K + S N+E+I
Sbjct: 302 QEKIKV---------------YEMEQDKKVENS----------------------NKEEI 324
Query: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
+ ++E + + I + ++K L +++ D L + Q++ K + ++
Sbjct: 325 QEKETIIEELNTK-------IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
+ K++ SE+++ +EL +R +D+ ++ ++ + A++
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
++ + ++ + ++ EL IR A +E + ++E + I
Sbjct: 438 DEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEME-----------NALRSYSNITVN 484
Query: 1950 EEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE 2008
E+++ ++ N+L +L DT S+K ++L ++EK L+ + + + + +
Sbjct: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSREQ 543
Query: 2009 VKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELL 2068
++ + + S ++E K + +++ + S++ + + E ++ + E+L
Sbjct: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
Query: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128
KE ++ R++ES ++ + + L E +L E H++ IEKL+ +
Sbjct: 604 EKEKNAVLDRMAES--QEAELERLRTQLLFSHEEELSKLKEDLEIEHRI--NIEKLKDNL 659
Query: 2129 EADEKKQL-----HIAEKLKERERENDSLKDKVENLEREL-QMSEENQELVILDAENSKA 2182
K+Q+ +++K++ + E D+L K L E+ ++ + Q LV +E
Sbjct: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL 719
Query: 2183 EVETLKTQIEEMARSLK---VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
++ L+ +IE + + K E ++ L+ + E L KQ++EK+ L E L + S+
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI 779
Query: 2240 L-EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
L +EK+ E +K + + E L + ++EI E++ D ++ Q
Sbjct: 780 LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK-QQCIQ 838
Query: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
L IEK R EK Q+L+ E +A LLK + + LE
Sbjct: 839 LNEEIEKQRNTFSFAEKNFEVNYQELQ--EEYACLLKVKDD-----------------LE 879
Query: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
+K E+E K+K++ + + L ++ T++ + + E + E++
Sbjct: 880 DSKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
Query: 2419 ENILQEKE---QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
++++ E +EK+++ ++ S L QLK+ + ++ L+ + ++ K +++ +S +
Sbjct: 939 TELMEKLEVTKREKLELSQRLSD----LSEQLKQKHGEISFLNEEVKSLKQEKEQVS--L 992
Query: 2476 ECLELE------KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529
C ELE +A+ +Q D ++ +L V + E K+ K E S++
Sbjct: 993 RCRELEIIINHNRAENVQSCDTQVSS--LLDGVVTMTSRGAEGSVSKVNKSFGEESKI-- 1048
Query: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL-TVELEQKIQVLQ-SKNASLQDTLEVLQ 2587
++D+ VS + GE K++ L L +L +V E ++ Q S+N LQ L VL+
Sbjct: 1049 MVEDK---VSFENMTVGEES--KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
Query: 2588 SSYKNLENELELTK----MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
S +L ++E + + + V++V + E E + + + ++ QEE E
Sbjct: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREY--MENEKDKALCSLKEELIFAQEEKIKEL 1161
Query: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL--DCMHKDQVEKEGKVREEIAEYQL 2701
++ +L+L + + + D+ K L L +L+K++ +C + Q +
Sbjct: 1162 QKI-HQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220
Query: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761
++ +K++ + N+ + E+Q YR ++ +E + + LL EE N L
Sbjct: 1221 EVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHT------LLNKVTEEYNKLLV 1272
Query: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA 2821
T+ L ++ + D +K + +EN + L I S Q+ ++I S+L +
Sbjct: 1273 LQTR-LSKIWGQQTDGMKL--EFGEENLPKEETEFLSIHS--QMTNLEDIDVNHKSKLSS 1327
Query: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Q+ +K TK++E E++ L +L+++ KE ++
Sbjct: 1328 LQDLEK------TKLEEQVQELESLISSLQQQLKETEQ 1359
Score = 145 bits (365), Expect = 8e-34
Identities = 218/1095 (19%), Positives = 473/1095 (43%), Gaps = 170/1095 (15%)
Query: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA---------DKSSREDIGDNVAK 1888
E+ + +KLE + QR S+G + + D S+ D+ + ++
Sbjct: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
Query: 1889 VNDSWKERFLDVENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN-- 1939
N+ + VE+ + + S + + + +E + E+ T C + N
Sbjct: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
Query: 1940 ----ENKQKVIVCLEEELSVVTSERNQLRGELDT-MSKKTTALDQLSEKMKEKTQELE-- 1992
+ + EEE V S Q + T + + L +++E +ELE
Sbjct: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1993 --SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
++ +E L +Q EA +K++ ++ L++++ + ++K + L + SQ L +
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 2051 KCELE-----------NQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKALEAAL 2097
+L+ + A L + K+ ++ + L Q L E DY+K ++ +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE-DYQKKKEDFTMQISF 300
Query: 2098 VEKGEFALRL-------SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
+++ + +S +EE+ + IE+L +I +EKK L + +KL ++
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 2151 SLKDKVENLERELQMSEENQELVILDAE----NSKAEVETLKTQIEEMAR---SLKVFEL 2203
L++++ +E+ +N +L + +++ S E++ L +EE+ + FE
Sbjct: 361 ELQEQIVQKNQEI----KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 2204 DLVTLRSEKENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ 2262
D+V + + ++ Q K QL +ELD++ Q +Q+K+ E+++
Sbjct: 417 DIV------QRMEQETQRKLEQLRAELDEMYG----------QQIVQMKQ------ELIR 454
Query: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
+ ++ E G+ E + ++ ++ + +I +L +L+ ++ + +
Sbjct: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
Query: 2323 QLKESEHHADLLKGRVENLERELEIAR----------TNQEHAALEAENSKGEVETLKAK 2372
+L L+ ++E+L EL +R QE EA S VE LKA+
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
Query: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-- 2430
I ++S + LEL E E+ N + + EKE+ V
Sbjct: 575 IVSASESRKELELK----------------------HEAEVTNYKIKLEMLEKEKNAVLD 612
Query: 2431 QMKEKSSTAMEMLQTQLK-ELNERVAALHNDQEA-----CKAKEQNL----SSQVECLEL 2480
+M E +E L+TQL E ++ L D E + + NL Q++ L+
Sbjct: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 672
Query: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-EKKDEEISRLKNQIQDQEQLVS 2539
E +Q ++ + K+N I Q+ + I +++D +Q L K EE++ N++Q + +++
Sbjct: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
Query: 2540 KLSQVEGE-HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
+ + +G Q +E L+ L ++++K LQ K A L+ +L+ K LE+ L+
Sbjct: 733 QEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK 792
Query: 2599 L----TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
+ ++ +++ F++ + K +K++ ++E+ + ++ +L+++ L
Sbjct: 793 IHTPVSQEERLIFLDSI-KSKSKDSVWEKEIEILIEENEDLKQQCI-----------QLN 840
Query: 2655 EEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA-EKK 2709
EEI+ ++ K + EL++ C+ K + + E ++ EY+ +L E+
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
H + T + + + +++ ++ LE+ + K TT+++E+
Sbjct: 901 HLQRINPTTVK-------MKSSVFDEDKTFVAETLEMGEVVE---------KDTTELMEK 944
Query: 2770 LKKTKMDNLKY---VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
L+ TK + L+ ++ L ++ ++ G++ L + K L++EKE + +L+
Sbjct: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
Query: 2827 KTGTVM--DTKVDEL 2839
+ V DT+V L
Sbjct: 1005 RAENVQSCDTQVSSL 1019
Score = 142 bits (357), Expect = 7e-33
Identities = 308/1574 (19%), Positives = 644/1574 (40%), Gaps = 226/1574 (14%)
Query: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
L KE + A Q+L + +KL KEK + Q Q + + LQKQ + +E + E +
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
Query: 65 L-----KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119
+ +N LM++ + + ++++ + + Q +E + + +++I+KLEQ+LK
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
S+ + + N + L KE+ ++++ER
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS------------KEQLQRDIQERN 2143
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
E E + ++ Q L H + S+ + ++R I R
Sbjct: 2144 E-EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL----------EVQLQAERDAIDR 2192
Query: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
E+E+T L+ + + + N L QL+ Q +E ++ EL
Sbjct: 2193 K--------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL-- 2239
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTKYT 358
E+E K + ++L L ++++ + + VL K + + DQ + + T
Sbjct: 2240 -----EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2294
Query: 359 ALEQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKE---KEFQEELSRQQRSFQTLDQE 413
L+Q+LK T++ + +N +E + ++E + +EE+ + + L QE
Sbjct: 2295 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2354
Query: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
+ + + + L+ +LD + + K LE +E +++ + + + K
Sbjct: 2355 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2414
Query: 474 ENELRRSMEEMKKE-----------NNLLKSHSEQKAREVCHLEAELKN--IKQCLNQS- 519
N+L + + +K+E N + + +++ LE L +K NQ+
Sbjct: 2415 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2474
Query: 520 -QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE 578
++F E K + ET L L+ ++ ++ L L + + D+++Q ++L+K+
Sbjct: 2475 FKSFEENGKGSIINLETRLLQLESTVSAKD--LELTQCYKQIKDMQEQGQFETEMLQKKI 2532
Query: 579 HHIEQLNDKLSKTEKESKALLSALELKK-KEYEEL-KEEKTLFSCWKSENEKLLTQMESE 636
+++++ + EK + AL+S ++L+ +EY + ++ +T+ S + N + L Q+
Sbjct: 2533 VNLQKIVE-----EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL--R 2585
Query: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
++ L S I+ L L+ +++S + E +L +++E + + + NVL+ + +E Q
Sbjct: 2586 EDELGSDISAL--TLRISELES-QVVEMHTSLILEKEQVEIAEK---NVLEKEKKLLELQ 2639
Query: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED-LEHKLQLLSNEIMDKDRCYQD 755
KL +++ E ++ +++E + T E ++L+ L E +
Sbjct: 2640 KLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS 2699
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE-- 813
+ E L++ L K+ ++ + Q+ L A +I+ ++ + S+
Sbjct: 2700 YKEKAEKLQEELLVKETNMTS---LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2756
Query: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQ--------MNSDLQKQC--EELVQIKGEI 863
C E + +I +L+ S +Q + +LQ +C EE+ +I +
Sbjct: 2757 CMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQF 2816
Query: 864 EENLMKAEQMHQSFVAE-TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
E + K +++H + + + S+ IS+ + H V + +Q L K
Sbjct: 2817 TEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK--- 2873
Query: 923 EQAEIQELKKSNHLLEDSLKELQLLS--------ETLSLEKKEMSSIISLNKREIEELTQ 974
E + I EL S D+ + ++ S + + L + I S + E E
Sbjct: 2874 EGSSIPELAHS-----DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESAT 2928
Query: 975 EN--GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK---------- 1022
++ +K + +++ E M ++ +ES Y D + SI ++S+ + +E+
Sbjct: 2929 DSFPKKIKGLLRAVHNEGMQVLSLTES--PYSDGEDHSIQQVSEPWLEERKAYINTISSL 2986
Query: 1023 --LILLQRCEETGNAYEDLSQKYKAAQEKNSKL-----ECLLNECTSLCENRKNELEQLK 1075
LI + + Y D SQ +++ + +L + L E + L + EL L
Sbjct: 2987 KDLITKMQLQREAEVY-DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG 3045
Query: 1076 EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTL 1135
A L + +E+ +E +Q+A R + ++ G K +TL
Sbjct: 3046 TTDAVGLLNCLEQR--IQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK---ITL 3100
Query: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE-RNQCNFKPQM 1194
K EQ + +K +LL+ N Q + + Q LE + +S+K+R +E + Q + + +
Sbjct: 3101 KREQ-ESEKPSQELLEYNIQ-------QKQSQMLEMQVELSSMKDRATELQEQLSSEKMV 3152
Query: 1195 DLEVK----------EISLDSYNAQLVQLEAM-----------------LRNKELKLQE- 1226
E+K E +L + + L +LEA L +++ K +E
Sbjct: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSREL 3212
Query: 1227 ---SEKEKECL-------QHELQTIRGDLETSNLQDMQ-----SQEISGLKDCEIDAEEK 1271
EKEK L + EL+ ++ LE+ +++Q Q+ L + + E +
Sbjct: 3213 QWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3272
Query: 1272 YISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITA 1331
+ +LS Q N LQ L++ ++ E+ + + +L + +S
Sbjct: 3273 RMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLP 3332
Query: 1332 TRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYE 1391
+ + +E+ K L E H +VE + NE L L E
Sbjct: 3333 SEDLLKELQKQLEE----------KHSRIVELL---------NETEKYKLDSLQTRQQME 3373
Query: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
K+ Q+H LQ + + K +H ++ SK+ +LQ ++ + + L
Sbjct: 3374 ------KDRQVHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDL 3423
Query: 1452 NLRNFQGDLVKEMQ 1465
+ QG +++E Q
Sbjct: 3424 EGQRLQG-IMQEFQ 3436
Score = 91.3 bits (225), Expect = 1e-17
Identities = 130/584 (22%), Positives = 263/584 (45%), Gaps = 71/584 (12%)
Query: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL--ELDVVTIRSE 2393
G+ NL RE E + ++ A++S +E +++++ G + L EL+ + +
Sbjct: 128 GKPTNLLREEEFG-VDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
Query: 2394 KENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKE--KSSTAMEMLQTQLKEL 2450
E L +LQ+ + I + + II N+ Q + ++ M+E + + + LQ Q ++L
Sbjct: 187 TEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
Query: 2451 NERVA---ALHNDQEA--CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
+ H+ A +AK+Q L+ Q + LE E+ LL+ + K ++ + ++
Sbjct: 246 QASETLRNSTHSSTAADLLQAKQQILTHQQQ-LE-EQDHLLEDYQKKKEDFTM---QISF 300
Query: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL 2565
L ++++ + + +KK E + K +IQ++E ++ +L+ + +E T+EL
Sbjct: 301 LQEKIKVYEMEQDKKVENSN--KEEIQEKETIIEELNT----------KIIEEEKKTLEL 348
Query: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
+ K+ LQ+ + KN++ EL +K + E++ ++ ELQ+
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK--DQLKELTLENSELKKSLDCMHK 2683
H+ +Q ++ + + E R +L+ L+E+ + +EL ++ + + HK
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 2684 DQVEKEGKVREEIA--EYQLRL-HEAEKKHQALLLDTNKQYEVEIQTYREK--LTSKEEC 2738
++E + I E Q++L + A + L DTN Q E +E+ L +E+C
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE----KLKEELGLILEEKC 524
Query: 2739 LSSQKLE--IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
++LE ++ L S+E++ + + + +L + +L V LK E A K
Sbjct: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASESRK 583
Query: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
L +L+ E E+ ++ +EK V+D + E++ L+
Sbjct: 584 EL-----ELKHEAEVTNYKIKLEMLEKEK---NAVLDRMAESQEAELERLR--------- 626
Query: 2857 ADEYLDKYCSLLISH-EKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
LL SH E+L K KE LE + H + + +D+ G
Sbjct: 627 --------TQLLFSHEEELSKLKEDLE--IEHRINIEKLKDNLG 660
Score = 48.9 bits (115), Expect = 8e-05
Identities = 124/624 (19%), Positives = 262/624 (41%), Gaps = 88/624 (14%)
Query: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICESLE 80
E++ +L +K + Q QL S + + + K ++ K E T LK +++ L E+
Sbjct: 3127 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL----- 3181
Query: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ--AAQSADVS 138
+ E++ K +V+ L S +K+ +L+ L++ K++L RS++ + D+
Sbjct: 3182 ---EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3238
Query: 139 LNPCNTPQKIFTTPLTPSQY-----YSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKK 192
+ + Q+ L Q S K E + Y+ ++ E + E++ L+++K
Sbjct: 3239 FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEK 3298
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQ------------------QEKTPSHLSSNSQR 234
+T++ Q SS + Q +EK + ++
Sbjct: 3299 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET 3358
Query: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL----DQLKAQNQEL 290
+ D + E++ R TLQ +++AN+ + H L + L+ Q +E
Sbjct: 3359 EKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANT---EGQKKMHELQSKVEDLQRQLEEK 3414
Query: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
R ++ +L+L Q ++G + +FQ+ +L+ E+ + E ++L + +E TT
Sbjct: 3415 RQQVYKLDLEGQ----RLQGIMQEFQKQELEREEKR----ESRRILYQNLNE--PTTWSL 3464
Query: 351 DQASTKYTALEQKLKKLTEDLSCQR---QNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
T+ L+QK++ T++ + + N C+ E E+ RQ+
Sbjct: 3465 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL-----------EMIRQKLQC 3513
Query: 408 QTLDQECIQMKARLTQELQQAKNMHNV-LQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
+ + KA + + A + + +Q +D++ Q+L E + +
Sbjct: 3514 VASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSC 3573
Query: 467 FQASQ--IKEN-ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
++ +++N EL + ++ +E N L++ V LE +++ +Q N +
Sbjct: 3574 GSLTERLLRQNAELTGHISQLTEEKNDLRN-------MVMKLEEQIRWYRQTGAGRDNSS 3626
Query: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQR------DCSQDLLKK 576
+ E ++ +E N+++ LTL+K LK A A++ K + Q L
Sbjct: 3627 RFSLNGGANIEAIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3684
Query: 577 REH-HIEQLNDKLSKTEKESKALL 599
EH ++++ K + E KAL+
Sbjct: 3685 SEHVTLKRIYGKYLRAESFRKALI 3708
Score = 48.9 bits (115), Expect = 8e-05
Identities = 101/531 (19%), Positives = 208/531 (39%), Gaps = 88/531 (16%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
+ WALE+ K KL + +++ + +L+ L+ +L+ QKQ +
Sbjct: 3212 LQWALEKEKA------------------KLGRSEERDKEELEDLKFSLESQKQ-----RN 3248
Query: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
NL E Q+ + L +++QKI + + ++Q++ ++G+ + +E + ++
Sbjct: 3249 LQLNLLLEQQK-----QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303
Query: 121 CKSELERSQQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE- 176
S L+R ++ QS+D T Q + P PS+ + L+EK+++ VE
Sbjct: 3304 MSSTLDRERELHAQLQSSD------GTGQ---SRPPLPSEDLLKELQKQLEEKHSRIVEL 3354
Query: 177 ----ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
E+ +L++ ++ Q + + + + T+ A + + Q +
Sbjct: 3355 LNETEKYKLDS-LQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3413
Query: 233 QRTPI-RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
+R + + D G + + + KR++ + N + P + R
Sbjct: 3414 KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP---TTWSLTSDRTR 3470
Query: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
N + L+ +++G KE +LIE C EL +
Sbjct: 3471 NWV--LQQKIEGETKESN----------------YAKLIEMNGGGTGCNHELEMIRQKLQ 3512
Query: 352 QASTKYTALEQKLKKL-------TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
++K L QK + ED ++N + L QK+ ++ E + L
Sbjct: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-QKLTGQQGE-EPSLVSPS 3570
Query: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464
S +L + ++ A LT + Q L E + L ++ +LE + ++Q +
Sbjct: 3571 TSCGSLTERLLRQNAELTGHISQ-------LTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623
Query: 465 QAFQAS----QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511
+ + S E + E +E L+ ++ EV L+AEL+N
Sbjct: 3624 NSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 285 bits (729), Expect = 5e-76
Identities = 631/3034 (20%), Positives = 1248/3034 (41%), Gaps = 479/3034 (15%)
Query: 174 EVEERKRLEAEVKALQAKKASQTLPQ--ATMNHRDIARHQASSSVFSWQQEKTPS----- 226
E+EE R E++ + Q L + A + RD Q ++++ ++EK +
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229
Query: 227 HLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
L+ SQ+ I+ + AS + + + L K+ + HLL+ +
Sbjct: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289
Query: 286 QNQELRNKINELELRLQGHEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCR 340
+ ++ +I+ L+ +++ +E E +V + QE + +E+ ++IE+EK + +
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349
Query: 341 DELVRTTAQYDQASTKYTALEQKLK----KLTEDLSCQRQNAESAR---CSLEQKIKEKE 393
D+L + + Q++K +LT +RQ++E + ++E+ K
Sbjct: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
Query: 394 KEFQEELSRQQRSFQTLDQECIQMKARL-----TQELQQAKNMHNVLQAELDKL-TSVKQ 447
K+ Q E QR Q ++ Q++A L Q +Q + + A+++++ T K
Sbjct: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
Query: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
++EN L + +Q + + NEL +++ + LK E C L+
Sbjct: 470 EMENALRSYSNITVNEDQ-IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQ 566
+L+++ + L+ S+ + + QE+ K+N+ SL T+E LK + +
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQES-------KLNEAHKSLSTVEDLKAEIVSASES 581
Query: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSE 625
R ++L K E + KL EKE A+L + E ++ E E L+ + LFS + E
Sbjct: 582 R---KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ-LLFS-HEEE 636
Query: 626 NEKLLTQMESE-KENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNL 682
KL +E E + N++ ++L K QQI +E ++++ T++ +++NL + L
Sbjct: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695
Query: 683 -----------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
++++SKS E+ Q ELQ++ E Q+ +++ L +
Sbjct: 696 ILEISKLKDLQQSLVNSKSEEMTLQ---INELQKEIEILRQEEKEK--------GTLEQE 744
Query: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
V++L+ K +LL ++ +K+ Q+ A+ E+ +LK + +L ED + Q+
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEE 801
Query: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMN 846
+ + + S+ + E +E ++ K I ++ + ++ F+ ++ +
Sbjct: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-----QRIS----KLQEDT-SAHQ 896
+LQ++ L+++K ++E++ K E ++S + + QRI+ K++ +
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921
Query: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELK----------KSNH----LLEDSLK 942
VAETL E EK+ L +K+E + E EL K H L + +K
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK 981
Query: 943 ELQLLSETLSLEKKEMSSIISLNKRE---------------IEELTQE--NGTLKEINAS 985
L+ E +SL +E+ II+ N+ E + +T G++ ++N S
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKS 1041
Query: 986 LNQEKMNLIQKSESFANYI----DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQ 1041
+E +++ SF N ++E+ I + +E + + E ++L+
Sbjct: 1042 FGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
Query: 1042 KYKAAQEKNSKLE----CL-------LNECTSLCENRKNE-LEQLKE--AFAKE------ 1081
+ ++E CL +++ EN K++ L LKE FA+E
Sbjct: 1102 LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKEL 1161
Query: 1082 ---HQEFLTKLAFAE--ERNQNLMLELETVQQALRSEMT--------------------- 1115
HQ L + E + + L L + +Q+A+ E +
Sbjct: 1162 QKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCE 1221
Query: 1116 ----DNQN-------NSKSEAGGLKQEIMTLKEEQ----NKMQKEVNDLLQENEQLMKV- 1159
D +N N E + E+ +E NK+ +E N LL +L K+
Sbjct: 1222 VNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIW 1281
Query: 1160 ------MKTKHECQNL---ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
MK + +NL E+E + + E N K ++ ++++ Q+
Sbjct: 1282 GQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLS-SLQDLEKTKLEEQV 1340
Query: 1211 VQLEAMLRNKELKLQESEKEKE----CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
+LE+++ + + +L+E+E+ E CLQ LQ + S S + + E
Sbjct: 1341 QELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV------SESTVPPSLPVDSVVITES 1394
Query: 1267 DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE---------- 1316
DA+ G +N + ++ S + + + + K+ E E+ E
Sbjct: 1395 DAQRTMYPGS---CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSM 1451
Query: 1317 -----LVTELND-SRSECITATRKMAEEVGK----LLNEVKILNDDSGLLHGELVEDIPG 1366
TEL+ S + TA+ K A V + NE+K+ D G E V+
Sbjct: 1452 SIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFK 1511
Query: 1367 GEFGEQPNE--QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424
EF E +H + SNS H K+ + + E+ S +
Sbjct: 1512 EEFKPLSKELGEHGKEIL---LSNSDPHDIPESKDCVL---TISEEMFSKDKTFIVRQSI 1565
Query: 1425 HCQMSSKMSELQTYVDSLKAENLVL--STNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP 1482
H ++S V S+ A ++ L + + +LV++ Q
Sbjct: 1566 HDEIS---------VSSMDASRQLMLNEEQLEDMRQELVRQYQ----------------- 1599
Query: 1483 DSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS---ANQCSVDEVFCSSLQEENLTRK 1539
+ + L + R + Q D L ++ A + S+D S + E + +
Sbjct: 1600 EHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVS-ERERVLLE 1658
Query: 1540 ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE----------QLLS 1589
E + + E LC R S + + E+QG ++ + +E E ++LS
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILS 1718
Query: 1590 SERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLD 1649
+ER L ++ +L + LE+ AA +E + R L LD
Sbjct: 1719 NERYAL-----------QKANNRLLKILLEVVKTTAA---------VEETIGRHVLGILD 1758
Query: 1650 LSSR--SLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIE 1707
SS+ S + + +SC + +EHT T E P + + + D+N+
Sbjct: 1759 RSSKSQSSASLIWRSEAEASVKSC-VHEEHTRVTDESIPSYSGSDM----PRNDINM-WS 1812
Query: 1708 KITETGA-----VKPTGECSGEQSPDT-----NYEPPGEDKTQGSSECISELSFSGPNAL 1757
K+TE G + +G E P+ N + + E ISE S +A
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK 1872
Query: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDR----DRKVESLLNEMKELDSKLH- 1812
V Q ++ R K+ + E+L+ + +R R E L E+ + + +
Sbjct: 1873 V------TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDG 1926
Query: 1813 ------LQEVQLMTKIEACIELEK-------IVGELKKENSDLSEKLEYFSCD------- 1852
L E Q+ K + LE+ + EL+ E + E+ E S
Sbjct: 1927 YADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE 1986
Query: 1853 ----HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVE---- 1901
Q+LLQ E +++ A+K R+D+ V + +E RF+++E
Sbjct: 1987 AGPVEQQLLQETEKLMKEKLEVQCQAEK-VRDDLQKQVKALEIDVEEQVSRFIELEQEKN 2045
Query: 1902 NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961
EL +R + ++E + LE + + + + E + + Q+ I LE++L VV R
Sbjct: 2046 TELMDLRQQNQALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVV--PRF 2100
Query: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021
Q E +T ++QL+ +KEKT + SE L + + +++E+ E ++ L
Sbjct: 2101 QPISE-----HQTREVEQLANHLKEKTDKC----SELLLSKEQLQRDIQERNEEIEKLEF 2151
Query: 2022 DVSEL---LKDKTHLQEKLQSLEKDSQALSLTKCELENQI-----AQLNKEKEL--LVKE 2071
V EL L +K++ + + + LE Q+ A KEKE+ L ++
Sbjct: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQ 2211
Query: 2072 SESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI--- 2128
E + L + E + LE ++K E RL ++E + +EKL + I
Sbjct: 2212 LEQFREELENKNEEVQQLHMQLE---IQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2268
Query: 2129 EADEKKQLHI-----AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183
+A + H+ A+ ++E+E E D L ++V L+++L+++ +N+ + E
Sbjct: 2269 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI-----EEKNEL 2323
Query: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKSLLEE 2242
+ L+TQIE + + + + E E L + I++ Q +L+ + K + SL EE
Sbjct: 2324 IRDLETQIECLMSDQECVKRN---REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE 2380
Query: 2243 ----KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
K Q ++ I E+ L+ Q++ NE + + + ++K T ++ +E
Sbjct: 2381 ADSLKHQLDVVIAEKL-----ALEQQVETANEEMTFM---KNVLKETNFKMNQLTQELFS 2432
Query: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
L+ E + E + L + + +++ E+ + LE NQ +
Sbjct: 2433 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV--LTEDALKSLE----NQTYFKSF 2486
Query: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
EN KG + L+ ++ + ++ +L++ + +++ + Q E E + + +I+N
Sbjct: 2487 EENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK-KIVN--- 2542
Query: 2419 ENILQEKEQEKVQMKEKSSTAMEMLQTQLK--ELNERVAA---LHNDQEACKAKEQNLSS 2473
LQ+ +EKV S +E +Q K + N+ +++ N Q + +E L S
Sbjct: 2543 ---LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
Query: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL----------EKKDEE 2523
+ L L ++L + E + I+ + V + V + ++KL EKK E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
Query: 2524 ISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE-LRNLTVELEQKIQVLQSKNASLQDT 2582
+ K QD E L + + LE LR +V + ++ + K LQ+
Sbjct: 2660 KEK-KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEE 2718
Query: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE 2642
L V +++ +L+ +L + D ++ ++ + KE E + + + A L +LS
Sbjct: 2719 LLVKETNMTSLQKDLSQVR-DHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKS 2777
Query: 2643 -KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701
++ G L++ SS +Q ++ ++N+ ++ +L + +V E I+++
Sbjct: 2778 IASQTDGTLKI------SSSNQTPQILVKNAGIQINLQSECSSE-----EVTEIISQFTE 2826
Query: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREK-----LTSKEECLSSQKLEIDLLKSSK--- 2753
++ + ++ H A +LD ++ E +T + + KEEC + K I L+S +
Sbjct: 2827 KIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEEC-GTLKAVIQCLRSKEGSS 2885
Query: 2754 --EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
E ++ T +I + Y+ + + ++G+ ++ E +
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGR-------GEESESATDS 2938
Query: 2812 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL--LI 2869
K++ L A + + T+ E +++ E +E Y++ SL LI
Sbjct: 2939 FPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLI 2998
Query: 2870 SHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLL 2903
+ +L++ E+ ++ +H +S D RG LL
Sbjct: 2999 TKMQLQREAEVYDSSQSH----ESFSDWRGELLL 3028
Score = 263 bits (671), Expect = 3e-69
Identities = 557/2742 (20%), Positives = 1126/2742 (41%), Gaps = 463/2742 (16%)
Query: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL-TQELQQA 428
D S Q A+ + LE + EL+ +Q + L++E +M+ T+ LQQ
Sbjct: 142 DDSYSEQGAQDSPTHLEM--------MESELAGKQHEIEELNRELEEMRVTYGTEGLQQL 193
Query: 429 KNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488
+ +A + + + QL NL++ +++ + F + +L+ ++++
Sbjct: 194 QEF----EAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE 249
Query: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
L S A ++ + ++ +Q L + + E+ + K + LQEKI E
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Query: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
+E+ K K + +++ ++++E IE+LN K+ + EK++ L L K
Sbjct: 310 ----MEQDK-------KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 609 YEELKEEKTLFSCWKSENEKL-LTQMESEKENLQSKINHLETCLKTQQIKSHE----YNE 663
EL +E+ + + +N KL LT + ++ +I L ++ Q ++H+ +
Sbjct: 359 LGEL-QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 664 RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCL 723
V+ +E + + ++R + + + + Q+L + Q E +H+ E+EN
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK-TRHKGEMENALR 476
Query: 724 KTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD----LLKSKDA------S 773
S +T E +++L++ I + + QD +++ E L++ +L+ K A
Sbjct: 477 SYSNITVN----EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED 532
Query: 774 LV-----TNEDHQRSLLAFDQQPA----MHHSFA---NIIGEQGSMPSERSECRLEADQS 821
LV + E QR+ +Q + H S + ++ E S R E L+ +
Sbjct: 533 LVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAE 592
Query: 822 PKN------------SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE-ENLM 868
N +A+L +S E LE + L EEL ++K ++E E+ +
Sbjct: 593 VTNYKIKLEMLEKEKNAVLDRMAESQEAELE--RLRTQLLFSHEEELSKLKEDLEIEHRI 650
Query: 869 KAEQMHQSFVAETSQRISKLQEDTS--------------AHQNVVAETLSALENKEKELQ 914
E++ + Q+I LQ + S QN + +S L K+ +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL--KDLQQS 708
Query: 915 LLNDKVETEQAEIQELKKSNHL----------LEDSLKELQLLSETLSLEKKEMSSIISL 964
L+N K E +I EL+K + LE ++ELQL +E L + KE + +
Sbjct: 709 LVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL-- 766
Query: 965 NKREIEELTQENGTLKE----------INASLNQEKMNLIQ---KSESFANYIDEREKSI 1011
+ + +L EN LK+ I+ ++QE+ + KS+S + ++ + +
Sbjct: 767 -QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 1012 SELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA-AQEKNSKLECLLNECTSLCENR-KN 1069
E ++ KQ+ + L + E+ N + + ++ QE + CLL L +++ K
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
Query: 1070 ELEQLKEAFAKEHQEFLTKL----------AFAEERN-QNLMLELETVQQALRSEMTDNQ 1118
ELE + A + L ++ F E++ LE+ V + +E+ +
Sbjct: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945
Query: 1119 NNSKSEAGGLKQEIMTLKEEQNK-------MQKEVNDLLQENEQL------MKVMKTKHE 1165
+K E L Q + L E+ + + +EV L QE EQ+ ++++ +
Sbjct: 946 EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 1166 CQNLES--------------------EPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
+N++S E + V + E ++ + ++ E + +S
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 1206 YNAQLVQLEAMLRNKELKLQESE-KEKECLQHELQTIRGDLETSNLQDMQSQEI--SGLK 1262
QL+ KE L+ ++ E + LQ EL ++ + LQ M++Q I S +
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ-MEAQRICLSLVY 1124
Query: 1263 DCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
+D +Y+ +N+ CSL+ + E EKI E+ + + EL T
Sbjct: 1125 STHVDQVREYM---------ENEKDKALCSLKEELIFAQE-EKIKELQKIHQLELQTMKT 1174
Query: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
+ + + +GKL K ++++ L + GE +
Sbjct: 1175 QETGD---EGKPLHLLIGKL---QKAVSEECSYFLQTLCSVL-----GEYYTPALKCEVN 1223
Query: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSL 1442
D+ NS ++++ ++ ELQ+ +Q + +H +++ + ++L
Sbjct: 1224 AEDKENSGDYISENED------PELQDYRYEVQDFQENMHTLLNKVTEEYNKL------- 1270
Query: 1443 KAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQ 1502
LVL T L G M+L E +P + + S +++L D
Sbjct: 1271 ----LVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDI--------- 1317
Query: 1503 TGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS 1562
D++ S L SSLQ+ T+ E + V+ELESL +Q
Sbjct: 1318 --DVNHKSKL----------------SSLQDLEKTKLE------EQVQELESLISSLQQQ 1353
Query: 1563 LEKLEEKMESQGIMKNKEIQELEQ--------LLSSERQELDCLRKQYLSENEQWQQKLT 1614
L++ E+ E++ K +Q + + + S E D R Y +K
Sbjct: 1354 LKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG---SCVKKNI 1410
Query: 1615 SVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
T+E + K++T + L + + QL+ + ++ ++ + A Q
Sbjct: 1411 DGTIEFSGEFGV-KEETNIVKLLEKQYQEQLE--EEVAKVIVSMSIAFAQQTELSRISGG 1467
Query: 1675 KEHTSETTERTPKHDVHQICDKDAQ--QDLNLDIEKI----TETGAV------KPTGECS 1722
KE+T+ + + H +C ++ ++ L ++I ET V KP +
Sbjct: 1468 KENTASSKQ------AHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 1723 GEQSPD---TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL----QLR 1775
GE + +N +P +++ ISE FS + + ++ + ++ QL
Sbjct: 1522 GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 1776 VKETSNENLR--LLHVIEDRDRKVESLLN-EMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
+ E E++R L+ ++ + E L M++++ + QE QL +I+ ++
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRL--NRQLA 1638
Query: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND- 1891
+N +L + E + E L+++ + E+ + ++ +N +V +
Sbjct: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698
Query: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV-CLE 1950
++KE+ LD + E + E++ E+ L+K N K+++ ++
Sbjct: 1699 TFKEKELDRKPE------------------DVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
+V + + G LD SK ++ + E E+ C+H E +
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWR------SEAEASVKSCVH-----EEHTR 1789
Query: 2011 EKTELLQTLS-SDV--------SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
E + + S SD+ S++ ++ T L ++L + T+ + EN+
Sbjct: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV-----RSGFAGTEIDPENE---- 1840
Query: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
EL++ S LQA + + S LE A V + E ++E + +
Sbjct: 1841 ----ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896
Query: 2122 EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE---ENQELVILDAE 2178
E+LR R+ + + + +A +L + E D D+ ER++Q + E +L A
Sbjct: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
Query: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD-KLLSSFK 2237
N E+E + QI+E E+E L++Q + + + ++ +LL +
Sbjct: 1957 NRLQELEAEQQQIQE-----------------ERELLSRQKEAMKAEAGPVEQQLLQETE 1999
Query: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
L++EK ++++ +++ + LQ Q+K L V E+ + IE E
Sbjct: 2000 KLMKEK----LEVQCQAEKVRDDLQKQVKALEIDV-------------EEQVSRFIELEQ 2042
Query: 2298 QLRNSIEKLRARLEADEKK----QLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
+ + LR + +A EK+ + + +Q + EH D+ + ++ LE++L++ Q
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
Query: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE- 2412
+E+ EVE L ++ T L L ++ + + E++K + R+ ELE
Sbjct: 2103 ----ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Query: 2413 ---IINSSFENILQEKEQEKVQMKEKSS---------TAMEMLQTQLKELNERVAALHND 2460
+ +F+ + K V+ K + S A++ + ++ L E++ +
Sbjct: 2159 ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
Query: 2461 QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
E + Q L Q+E + E LQ L++ + +D +KL
Sbjct: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF--------------KDDMEKLGLA 2264
Query: 2521 DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKI------QVLQS 2574
+E + QDQ L K +Q+ E ++ +Q L +L+Q++ +V++
Sbjct: 2265 IKESDAMST--QDQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKITTDNKVIEE 2319
Query: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE 2634
KN ++D L++ + L ++ E K ++ +E++N++ K LQ+E+ + QKT+
Sbjct: 2320 KNELIRD----LETQIECLMSDQECVKRNREEEIEQLNEVIEK---LQQELANIGQKTSM 2372
Query: 2635 LQEELSGEKNRLAGELQLLL--------------EEIKSSKDQLKELTLENSELKKSLDC 2680
LS E + L +L +++ EE+ K+ LKE + ++L + L
Sbjct: 2373 NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFS 2432
Query: 2681 M--HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE- 2737
+ ++ VEK + E + +K ++L + +E QTY + +
Sbjct: 2433 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2492
Query: 2738 ---CLSSQKLEIDLLKSSKE-ELNNSLKATTQILEELK-KTKMDNLKYVNQLKKENERAQ 2792
L ++ L+++ S+K+ EL K + E+ + +T+M K VN K E
Sbjct: 2493 SIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE--- 2549
Query: 2793 GKMKLLIKSCKQLEEEKEILQ--KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETL 2850
K+ + S QLE +E + ++ + + E+ + + DEL ++I L +
Sbjct: 2550 -KVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2608
Query: 2851 EEKTKEADEYLDKYCSLLISHEK--------LEKAKEMLETQ 2884
E + ++ + SL++ E+ LEK K++LE Q
Sbjct: 2609 SELESQV---VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ 2647
Score = 250 bits (638), Expect = 2e-65
Identities = 646/3293 (19%), Positives = 1318/3293 (40%), Gaps = 596/3293 (18%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ----KQKQKVENEKTEGTNLKRENQRLM 73
Q+++E + L+ +K+K+ Q+ L+ ++ +Q +KVEN E +E + ++
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI---QEKETII 331
Query: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
E + ++K + EL+ K + + G+L ++QI + QE+K K EL S+Q +
Sbjct: 332 EELNTKIIEEEKKTLELKDKLTTADKLLGEL---QEQIVQKNQEIKNMKLELTNSKQKER 388
Query: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE-DLKEKYNKEVEER-KRLEAEVKALQAK 191
+ + Q + T + + S++E D+ ++ +E + + ++L AE+ + +
Sbjct: 389 QSSEEIK-----QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQ 443
Query: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQE---KTPSHLSSNSQRTPIRRDFSASYFSG 248
+ Q + H +A+ + + + E ++ S+++ N + +
Sbjct: 444 QIVQMKQELIRQH--MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIK 501
Query: 249 EQEVTPSRSTL--QIG---------KRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Q+ + L ++G +R + S S + + + E +K+NE
Sbjct: 502 LQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA 561
Query: 298 ELRLQGHEKEMKGQVNKFQELQLQLE----------KAKVELIEKEKVLNKCRDELVRTT 347
L E ++K ++ E + +LE K K+E++EKEK N D + +
Sbjct: 562 HKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQ 618
Query: 348 -AQYDQASTKYT-ALEQKLKKLTEDLSCQ-RQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
A+ ++ T+ + E++L KL EDL + R N E + +L K++ Q E+S++
Sbjct: 619 EAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678
Query: 405 RSFQTLDQECIQMKARLTQELQQAKNMH-NVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
+ Q I + +L E+ + K++ +++ ++ +++T +L+ +E +Q+
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEK 738
Query: 464 ---EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL---- 516
EQ Q Q+K L + M+E KEN+L + ++ +A E L+ E K ++ L
Sbjct: 739 GTLEQEVQELQLKTELLEKQMKE--KENDLQEKFAQLEA-ENSILKDEKKTLEDMLKIHT 795
Query: 517 --NQSQN--FAEEMKAKNTSQ------ETMLRD----------LQEKINQQENSLTLEKL 556
+Q + F + +K+K+ E ++ + L E+I +Q N+ + +
Sbjct: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855
Query: 557 KLAV--ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL------------ 602
V +L+++ C LLK ++ L D +K E E K+ L AL
Sbjct: 856 NFEVNYQELQEEYAC---LLKVKD----DLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 603 --ELKKKEYEELK----EEKTLFSCWKSENEKLLTQME---SEKENLQSKINHLETCLKT 653
++K ++E K E + + + +L+ ++E EK L +++ L LK
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
Query: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
+ + NE V++L+ ++E +S+ R L +++ E + D +
Sbjct: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAE-------------NVQSCDTQ 1015
Query: 714 HQKEIENMCLKTSQ-LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772
++ + TS+ G V + S +++ ++++ ES ++ L
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 773 SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD-QSPKNSAILQNR 831
VT E R+ QP+ + E + SE+++ RL+ + Q S +
Sbjct: 1076 PSVTKESSLRAT-----QPSENDKLQK---ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA--ETSQR----- 884
VD + +E++K + L EEL+ + E + L K Q+ + ET
Sbjct: 1128 VDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
Query: 885 --ISKLQEDTSAHQNVVAETLSAL---------------ENKEKELQLLNDKVETE---- 923
I KLQ+ S + +TL ++ E+KE +++ + E
Sbjct: 1186 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 924 QAEIQELKKSNHLLEDSLKE------------------------LQLLSETLSLEKKEMS 959
+ E+Q+ +++ H L + + E L+ E L E+ E
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 960 SIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK 1019
SI S +E++ + + ++++ + EK L ++ + + I ++ + E Y+
Sbjct: 1306 SIHS-QMTNLEDIDVNHKS--KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYE 1362
Query: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
E L +R + + S + S + + + + +N +E E
Sbjct: 1363 AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGV 1422
Query: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
KE + L E+ LE E + + + Q S G K+ + K+
Sbjct: 1423 KEETNIVKLL----EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478
Query: 1140 NKMQKE---VNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195
Q+E N++ +Q+ + +T E +P+ + E E N P
Sbjct: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538
Query: 1196 LEVKE----ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ 1251
E K+ IS + ++ + + E+ + + ++ + +E Q L+
Sbjct: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ----------LE 1588
Query: 1252 DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICE--I 1309
DM+ + + ++ + E + ++ + D LQ ++ +L + I +
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648
Query: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
+ + L+ EL + + K+ E+ + + N++ G ++ F
Sbjct: 1649 VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--------EVEEQTF 1700
Query: 1370 GEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS 1429
E+ ++ P + P SN L ++ + E+ + +++ S
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 1430 SKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP------- 1482
SK + + +AE V S V E + + +PS S S +P
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSC---------VHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 1483 -----DSSSLSS-LGDSSFYRALLEQTGD---MSLLSNLEGAV---------SANQCSVD 1524
+ + LS L S F ++ + +++ S L+ AV +++Q
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 1525 EVFCSSLQEENLTRKETPSAPAKGVEEL-ESLCEVYRQSLEKLEEKMESQGIMKN----- 1578
+V + L E+ +K+ + K EEL E L E R + E +++G++
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931
Query: 1579 ----KEIQELEQLLSSERQELDCL--RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTE 1632
++IQE ++ QEL C R Q L +Q Q+ + + + AE E
Sbjct: 1932 TLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE 1991
Query: 1633 QLSLELEVARLQLQGLDLSSRS------------LLGIDTEDAI--------QGRNESCD 1672
Q L+ E +L + L++ ++ L ID E+ + + E D
Sbjct: 1992 QQLLQ-ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 1673 ISKEHTS--ETTERTPKHDVHQICDKDAQQDL-NLDIEKITETGAVKPTGECSGEQSPDT 1729
+ +++ + + E+ K Q D++ ++D+ +I+K+ + V P + E
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQT-R 2109
Query: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + + +C SEL S + D E+I L+ RV+E + L V
Sbjct: 2110 EVEQLANHLKEKTDKC-SELLLSKEQ--LQRDIQERNEEIEKLEFRVRELE----QALLV 2162
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQ-EVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
D +KVE +++K L EVQL + +A EK + L+++ E+LE
Sbjct: 2163 SADTFQKVEDR-KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
Query: 1849 FSCDHQEL--------------LQRVETSEGL-NSDLEM------HADKSSRED------ 1881
+ + Q+L LQ +E L D+E +D S +D
Sbjct: 2222 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2281
Query: 1882 -----IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY--LEADLEVVQTEKLC 1934
I + ++ D E+ ++ +L K E L LE +E + +++ C
Sbjct: 2282 KFAQIIQEKEVEI-DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
Query: 1935 LEKDNENK----QKVIVCLEEELSVV-----------TSERNQLRGELDTMSKKTTALDQ 1979
++++ E + +VI L++EL+ + + E + L+ +LD + + AL+Q
Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
Query: 1980 LSE------------------KMKEKTQELES--HQSECLHCIQ-VAEAEV--------K 2010
E KM + TQEL S + E + IQ + E V K
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
Query: 2011 EKTELLQTLSSDVSELLKDKTH--------------LQEKLQSLEKDSQA--LSLTKC-- 2052
+K EL L+ D + L+++T+ L+ +L LE A L LT+C
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
Query: 2053 ELENQIAQLNKEKELLVKESESLQARLSE-----------------------------SD 2083
++++ Q E E+L K+ +LQ + E S+
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580
Query: 2084 YEKLNVSKALEAALVEKGE----FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
E+ N+ + E G LR+S + +V ++ + + ++E EK L
Sbjct: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640
Query: 2140 EKL------------KERERENDSLKDKVENLERELQMSEENQE------LVILDAEN-- 2179
+KL K+RE+E VE L+ ++ N+E L L AE+
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
Query: 2180 SKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK-----LLS 2234
+KAE+ + K + E++ L V E ++ +L+ + + + E + +LS L+K +
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
Query: 2235 SFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE 2294
S K+ + E ++ S+T + + + + + G Q I +E S + E
Sbjct: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ-INLQSECSSEEVTE 2819
Query: 2295 EEHQLRNSIEKLRARLEAD----EKKQLCVLQQLKESEHHA-DLLKGRVENLERELEIAR 2349
Q IEK++ A+ E + + + LK + A LLK L+ ++ R
Sbjct: 2820 IISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2879
Query: 2350 TNQEHAALE----------------------------------------AENSKGEVETL 2369
+ + + E E S+ ++
Sbjct: 2880 SKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSF 2939
Query: 2370 KAKIEGMTQSLRGLELDVVTIR----SEKENLTNELQKE---QERISELEIINSSFENIL 2422
KI+G+ +++ + V+++ S+ E+ + + E +ER + + I+S + I
Sbjct: 2940 PKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLIT 2999
Query: 2423 QEKEQEKVQMKEKSST-----------AMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
+ + Q + ++ + S + + + Q L+E + +AA + A +
Sbjct: 3000 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA-- 3057
Query: 2472 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE------DGKQKLEKKDEEIS 2525
+ CLE + QG++ + ++ L+ E++ +G++ K+++E
Sbjct: 3058 VGLLNCLEQRIQE--QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE 3115
Query: 2526 RLKNQIQDQ--EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL 2583
+ ++ + +Q S++ +++ E K++ EL+ + + L+S+ A + L
Sbjct: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
Query: 2584 EV-LQSSYKNLENELELTKM---DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL 2639
E L++ +K+L+ ELE ++ DK V +N A E + K+ ELQ L
Sbjct: 3176 ETTLKAQHKHLK-ELEAFRLEVKDKTDEVHLLNDTLASEQK----------KSRELQWAL 3224
Query: 2640 SGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY 2699
EK +L + EE++ K L+ N +L L+ + E + K+ + Y
Sbjct: 3225 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3284
Query: 2700 QLRLHEAEKKH---QALL-------------LDTNKQYEVEIQTYREKLTSKEECLSSQK 2743
+L E + ++ Q LL LD ++ ++Q+ S+ S
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-- 3342
Query: 2744 LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK 2803
DLLK +++L ++L E +K K+D+L ++ +
Sbjct: 3343 ---DLLKELQKQLEEKHSRIVELLNETEKYKLDSL---------------------QTRQ 3378
Query: 2804 QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Q+E+++++ +K L Q +Q+ T K+ EL +++++L+ LEEK ++
Sbjct: 3379 QMEKDRQVHRKTL------QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQ 3425
Score = 245 bits (625), Expect = 6e-64
Identities = 646/3256 (19%), Positives = 1300/3256 (39%), Gaps = 554/3256 (17%)
Query: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKR- 67
KE + KI E E + +LK + L L+ + ++ Q+++N K E TN K+
Sbjct: 327 KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 68 ------ENQRLMEICESLEKTKQKISH-ELQVKESQVNFQEGQLNSGKKQIEKL-EQELK 119
E ++LM E L+K K S E + + + +L + +++++ Q++
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
+ K EL R A + E++K ++ E+E
Sbjct: 447 QMKQELIRQHMA-------------------------------QMEEMKTRHKGEMENAL 475
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS-SNSQRTPIR 238
R + + + L +N +I +S Q+EK L ++ ++
Sbjct: 476 RSYSNI---TVNEDQIKLMNVAINELNIKLQDTNS-----QKEKLKEELGLILEEKCALQ 527
Query: 239 RDFSASYFSGEQEVTPSRSTLQIGKR---DANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
R +E++ SR +Q ++ + S + S ++ LKA+
Sbjct: 528 RQLEDLV----EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583
Query: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT-TAQYDQAS 354
ELEL+ HE E+ K K+E++EKEK N D + + A+ ++
Sbjct: 584 ELELK---HEAEVTNY------------KIKLEMLEKEK--NAVLDRMAESQEAELERLR 626
Query: 355 TKYT-ALEQKLKKLTEDLSCQ-RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
T+ + E++L KL EDL + R N E + +L K++ Q E+S++ + Q
Sbjct: 627 TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD 686
Query: 413 ECIQMKARLTQELQQAKNM-HNVLQAELDKLTSVKQQLENNLEEFKQ---KLCRAEQAFQ 468
I + +L E+ + K++ +++ ++ +++T +L+ +E +Q + EQ Q
Sbjct: 687 NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 746
Query: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL------NQSQN- 521
Q+K L + M+E KEN+L + ++ +A E L+ E K ++ L +Q +
Sbjct: 747 ELQLKTELLEKQMKE--KENDLQEKFAQLEA-ENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 522 -FAEEMKAK----------------NTSQETMLRDLQEKINQQENSLTLEKLKLAV--AD 562
F + +K+K N + L E+I +Q N+ + + V +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL--------------ELKKKE 608
L+++ C LLK + + L D +K E E K+ L AL ++K
Sbjct: 864 LQEEYAC---LLKVK----DDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 609 YEELK----EEKTLFSCWKSENEKLLTQME---SEKENLQSKINHLETCLKTQQIKSHEY 661
++E K E + + + +L+ ++E EK L +++ L LK + +
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Query: 662 NERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENM 721
NE V++L+ ++E +S+ R L +++ E + D + ++ +
Sbjct: 977 NEEVKSLKQEKEQVSLRCRELEIIINHNRAE-------------NVQSCDTQVSSLLDGV 1023
Query: 722 CLKTSQ-LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
TS+ G V + S +++ ++++ ES ++ L VT E
Sbjct: 1024 VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS 1083
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD-QSPKNSAILQNRVDSLEFSL 839
R+ QP+ + E + SE+++ RL+ + Q S + VD + +
Sbjct: 1084 LRA-----TQPSENDKLQK---ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM 1135
Query: 840 ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV--AETSQR-------ISKLQE 890
E++K + L EEL+ + E + L K Q+ + ET I KLQ+
Sbjct: 1136 ENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQK 1193
Query: 891 DTSAHQNVVAETLSAL---------------ENKEKELQLLNDKVETE----QAEIQELK 931
S + +TL ++ E+KE +++ + E + E+Q+ +
Sbjct: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ 1253
Query: 932 KSNHLLEDSLKE------------------------LQLLSETLSLEKKEMSSIISLNKR 967
++ H L + + E L+ E L E+ E SI S
Sbjct: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS-QMT 1312
Query: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
+E++ + + ++++ + EK L ++ + + I ++ + E Y+ E L +
Sbjct: 1313 NLEDIDVNHKS--KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQK 1370
Query: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
R + + S + S + + + + +N +E E KE +
Sbjct: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVK 1430
Query: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE-- 1145
L E+ LE E + + + Q S G K+ + K+ Q+E
Sbjct: 1431 LL----EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQH 1486
Query: 1146 -VNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE--- 1200
N++ +Q+ + +T E +P+ + E E N P E K+
Sbjct: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
Query: 1201 -ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
IS + ++ + + E+ + + ++ + +E Q L+DM+ + +
Sbjct: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ----------LEDMRQELVR 1596
Query: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC--EILQAEKYEL 1317
++ + E + ++ + D LQ ++ +L + I ++ + L
Sbjct: 1597 QYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVL 1656
Query: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377
+ EL + + K+ E+ + + N++ G ++ F E+ ++
Sbjct: 1657 LEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--------EVEEQTFKEKELDRK 1708
Query: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQT 1437
P + P SN L ++ + E+ + +++ SSK +
Sbjct: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
Query: 1438 YVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP------------DSS 1485
+ +AE V S V E + + +PS S S +P + +
Sbjct: 1769 LIWRSEAEASVKS---------CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819
Query: 1486 SLSS-LGDSSFYRALLEQTGD---MSLLSNLEGAV---------SANQCSVDEVFCSSLQ 1532
LS L S F ++ + +++ S L+ AV +++Q +V + L
Sbjct: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELM 1879
Query: 1533 EENLTRKETPSAPAKGVEEL-ESLCEVYRQSLEKLEEKMESQGIMK---------NKEIQ 1582
E+ +K+ + K EEL E L E R + E +++G++ ++IQ
Sbjct: 1880 RESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ 1939
Query: 1583 ELEQLLSSERQELDCL--RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEV 1640
E ++ QEL C R Q L +Q Q+ + + + AE EQ L+ E
Sbjct: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ-ET 1998
Query: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS-KEHTSETTERTPKHDVHQICDKDAQ 1699
+L + L++ ++ D +Q + ++ +I +E S E + + + +
Sbjct: 1999 EKLMKEKLEVQCQA---EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055
Query: 1700 QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVP 1759
Q L +EK+ + EQ+ D +E
Sbjct: 2056 QALEKQLEKMR---------KFLDEQAIDREHE--------------------------- 2079
Query: 1760 MDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD---SKLHLQEV 1816
D Q++I L+ ++K R + E + R+VE L N +KE S+L L +
Sbjct: 2080 RDVF--QQEIQKLEQQLKVVP----RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 1817 QLMTKI-EACIELEKIVGELKKENSDLSEKLEYF-SCDHQELLQRVETSEGLNSDLEMHA 1874
QL I E E+EK+ +++ L + F + ++ VE L+ ++++ A
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 2193
Query: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC 1934
++ + D ++ ++E +L + R E + E L LE+ + E
Sbjct: 2194 ERDA-----------IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242
Query: 1935 ----LEKDN----ENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMK 1985
LE++N ++ +K+ + ++E ++ T +++ L G+ + +K +DQL+E++
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
Query: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL-QEKLQSLEKDS 2044
+ Q+L+ I ++EK EL++ L + + L+ D+ + + + + +E+ +
Sbjct: 2303 KLQQQLK---------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLN 2353
Query: 2045 QALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA 2104
+ + + EL N + + L +E++SL+ +L EKL + + +E A E
Sbjct: 2354 EVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMK 2413
Query: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE---NLER 2161
L T +++QL + + L+ E+ EK Q I E ++ S KDK E L
Sbjct: 2414 NVLKETNFKMNQLTQELFSLKRERESVEKIQ-SIPENSVNVAIDHLS-KDKPELEVVLTE 2471
Query: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
+ S ENQ EN K + L+T++ ++ ++ +L+L + +++ +Q
Sbjct: 2472 DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ--- 2528
Query: 2222 KQGQLSELDKLLSSFKSLLEEKEQA----EIQIK-----------------EESKTAVEM 2260
Q + L K + + + ++EEK A +IQ++ E +T ++
Sbjct: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
Query: 2261 LQNQLK--ELNEAVAAL-CGDQEIMKATEQSLDPPIEEEHQL----RNSIEK------LR 2307
L NQL+ EL ++AL E+ + I E+ Q+ +N +EK L+
Sbjct: 2589 L-NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ 2647
Query: 2308 ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN--SKGE 2365
LE +EKKQ ++ K S ++LK E E N E AL AE+ +K E
Sbjct: 2648 KLLEGNEKKQR--EKEKKRSPQDVEVLKTTTELFHSNEESGFFN-ELEALRAESVATKAE 2704
Query: 2366 VETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEK 2425
+ + K K E + + L E ++ +++ + + + L + +E++S I+ E +QE
Sbjct: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS---ILEKEDETEVQES 2761
Query: 2426 EQ----EKVQMKEKSSTAMEMLQT-------QLKELNERVAALH-NDQEACKAKE-QNLS 2472
++ E + +K S A + T Q ++ + A + N Q C ++E +
Sbjct: 2762 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2821
Query: 2473 SQ-------------VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-- 2517
SQ E L++E + + + +Y+ +Q L++E E G K
Sbjct: 2822 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ-----LLKE-ECGTLKAVI 2875
Query: 2518 ----EKKDEEISRLKNQIQDQEQLVSK------------LSQVEGEHQLWKEQNLELRNL 2561
K+ I L + Q + + L+ +G + + E +
Sbjct: 2876 QCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
Query: 2562 TVELEQKIQ-VLQSKNASLQDTLEVLQSSYK-----NLENELELTKMDKMSFVEKVNKMT 2615
T +KI+ +L++ + L + +S Y +++ E ++ +++ ++ +
Sbjct: 2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK 2995
Query: 2616 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS---SKDQLKELTLENS 2672
T++Q + +++ E S + L LQ + E +S + + + L +
Sbjct: 2996 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT 3055
Query: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQL------------------------------- 2701
+ L+C+ E +++E+ EYQ
Sbjct: 3056 DAVGLLNCL-------EQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITL 3108
Query: 2702 -RLHEAEKKHQALLLDTNKQ-------YEVEIQTYREKLTSKEECLSSQKLEIDLLKS-- 2751
R E+EK Q LL +Q +VE+ + +++ T +E LSS+K+ + LKS
Sbjct: 3109 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3168
Query: 2752 --SKEELNNSLKATTQILEELK------KTKMDNLKYVNQ-LKKENERAQGKMKLLIKSC 2802
+K EL +LKA + L+EL+ K K D + +N L E ++++ L K
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
Query: 2803 KQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLD 2862
+L +E ++EL L+ + E QK + +L +++ K+ L E ++ +
Sbjct: 3229 AKLGRSEERDKEELEDLKFSLESQKQRNL------QLNLLLEQQKQLLNESQQKIESQRM 3282
Query: 2863 KYCSLLISHE----KLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTE 2918
Y + L + +L+ E + ++ + S ++ + L G S P +E
Sbjct: 3283 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3342
Query: 2919 KRLSSGQNKASGKRQR 2934
L Q + K R
Sbjct: 3343 DLLKELQKQLEEKHSR 3358
Score = 192 bits (489), Expect = 3e-48
Identities = 530/2887 (18%), Positives = 1157/2887 (40%), Gaps = 458/2887 (15%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77
+I L ++ LK+EK+Q + LE + + EN ++ T + ++ +
Sbjct: 972 EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR--AENVQSCDTQVSSLLDGVVTMTSR 1029
Query: 78 ----SLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE-RSQQA 131
S+ K + E ++ E +V+F+ + KQ + + L E R+ Q
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Query: 132 AQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
+++ + LN + Q + + Y ++ + +E K KAL
Sbjct: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD-----KALC 1144
Query: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQ---EKTPSHLSSNSQRTPIRRDFSASYF 246
+ K Q HQ Q+ E P HL + + + SYF
Sbjct: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYF 1202
Query: 247 S-------GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
GE + + ++ + + + P L Q+ R ++ + +
Sbjct: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL--------QDYRYEVQDFQE 1254
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
+ ++ + NK LQ +L K + + K L + L + ++ ++ T
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK-LEFGEENLPKEETEFLSIHSQMTN 1313
Query: 360 LEQ-------KLKKLTE----DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
LE KL L + L Q Q ES SL+Q++KE E+ ++ E+ Q+ Q
Sbjct: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 409 TLDQECIQMKAR-----LTQELQQA---------KNMHNVLQAE----LDKLTSVKQQLE 450
+ + + +T+ Q KN+ ++ + + T++ + LE
Sbjct: 1374 AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE 1433
Query: 451 NNLEE-FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
+E ++++ + + + ++ EL R KEN S ++A VC E
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTA----SSKQAHAVCQQEQHY 1487
Query: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
N + L+Q Q + + + + + L +++ + + L D+ + +DC
Sbjct: 1488 FN-EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD--PHDIPESKDC 1544
Query: 570 ----SQDLLKKREHHI--EQLNDKLSKTEKESKALLSALE-----LKKKEYEELKEEKTL 618
S+++ K + I + ++D++S + ++ L E ++++ + +E +
Sbjct: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604
Query: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY----NERVRTLEMD--- 671
+ + + + + ++E LQ +I L L + +E ERV E++
Sbjct: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664
Query: 672 ------RENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAE-----------FSD 711
RE L E+RN + + EVE Q EL +K E ++
Sbjct: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYAL 1724
Query: 712 QKHQKEIENMCLKTSQLTGQVEDL--EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
QK + + L+ + T VE+ H L +L + +E E+
Sbjct: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784
Query: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER----SECRLEADQSPKNS 825
++ + VT+E + P + + + E+G+ S+R E D P+N
Sbjct: 1785 EEHTRVTDESIPS--YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID--PENE 1840
Query: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQR 884
++ N L+ ++E + S+ Q E + E+ E+ + ++ +S + R
Sbjct: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900
Query: 885 ISKLQEDTSAHQNVVAETLSA---LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+L E++ A + + E A ++ E L +++ + I L++ + L
Sbjct: 1901 -ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
+EL+ + + E++ +S K E + Q+ L + L +EK+ + ++E
Sbjct: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVR 2016
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
D+ +K + L +++ ++ +E DL Q+ +A +++ K+ L+E
Sbjct: 2017 ---DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
Query: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
+R++E + ++ K Q+ F + +++ E+E + L+ E TD +
Sbjct: 2074 I---DREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLK-EKTDKCSEL 2128
Query: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHECQNLESEPIRNS 1177
L+++I EE K++ V +L Q + KV KH +E++P +
Sbjct: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSL 2187
Query: 1178 VKERESERNQCNFKPQMDLEVKEISLDSYNAQL-----------VQLEAMLRNKELKLQE 1226
+ ++ER+ + K + ++E L+ + +L +QLE + +LQE
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEE-QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2246
Query: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
E+E + + +++ + ++ S+ Q Q + K +I E++ E+
Sbjct: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV-----EIDQLNEQV 2301
Query: 1287 AHLQCSLQ-TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNE 1345
LQ L+ TT NK+ E EK EL+ +L +++ EC+ + ++ + + E
Sbjct: 2302 TKLQQQLKITTDNKVIE----------EKNELIRDL-ETQIECLMSDQECVKRNRE--EE 2348
Query: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPN-EQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
++ LN+ L EL G++ + H +S +E++S +H ++ +
Sbjct: 2349 IEQLNEVIEKLQQELAN------IGQKTSMNAHSLS----EEADSLKH------QLDVVI 2392
Query: 1405 AE---LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV 1461
AE L+++ + E + + + + KM++L + SLK E ++ Q
Sbjct: 2393 AEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIPE 2448
Query: 1462 KEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS------NLEGA 1515
+ + ++ V +L SL + +++++ E+ G S+++ LE
Sbjct: 2449 NSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLEST 2507
Query: 1516 VSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI 1575
VSA + + + + + ET K + L+ + E + L +++ + +
Sbjct: 2508 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKK-IVNLQKIVE--EKVAAALVSQIQLEAV 2564
Query: 1576 MKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ---------KLTSVTLEMESKLAA 1626
+ + + Q +SSE + + L E+E +L S +EM + L
Sbjct: 2565 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLIL 2624
Query: 1627 EKKQTEQLS---LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
EK+Q E LE E L+LQ L ++G K+ + +
Sbjct: 2625 EKEQVEIAEKNVLEKEKKLLELQKL---------------LEGNE------KKQREKEKK 2663
Query: 1684 RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743
R+P+ D+E + T + + E SG
Sbjct: 2664 RSPQ-----------------DVEVLKTTTELFHSNEESG-------------------- 2686
Query: 1744 ECISEL-SFSGPNALVPMDFLGNQEDIHNLQ--LRVKETSNENLRLLHVIEDRDRKVESL 1800
+EL + + + +E LQ L VKET+ +L+ + + +
Sbjct: 2687 -FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ---------KDLSQV 2736
Query: 1801 LNEMKELDSKLHLQEVQLMTKIE----AC------IELEKIV-----GELKKENSDLSEK 1845
+ + E KL + E + T+++ AC I+L K + G LK +S+ + +
Sbjct: 2737 RDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQ 2796
Query: 1846 LEYFS----------CDHQELLQRV-ETSEGLNSDLEMHA----DKSSREDIGDNVAKVN 1890
+ + C +E+ + + + +E + E+HA D SR ++++
Sbjct: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR-----HISETE 2851
Query: 1891 DSWKERFLDVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
+E ++ V+ + KA I E ++ A + QT ++C + +
Sbjct: 2852 TLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
Query: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL----- 1999
I + + SE RGE + +A D +K+K + + + + L
Sbjct: 2912 GIYLTHSQGFDIASEG---RGE-----ESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2963
Query: 2000 -------HCIQ-VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051
H IQ V+E ++E+ + T+SS + K + + ++ + ++ S +
Sbjct: 2964 PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWR 3023
Query: 2052 CELENQIAQLN-KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSS 2109
EL + Q+ +E+ +L+ + L +D + + LE + E+G E+ +
Sbjct: 3024 GELLLALQQVFLEERSVLLAAFRTELTALGTTD--AVGLLNCLEQRIQEQGVEYQAAMEC 3081
Query: 2110 TQE--------EVHQLRRGIEKLRVRIEADEKKQLHIAEKLK-----------EREREND 2150
Q+ E+ L + ++ ++ +++ + E L+ E + E
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Query: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVE---TLKTQIEEMARSLKVFELDLVT 2207
S+KD+ L+ Q+S E + L +E ++ ++E TLK Q + + + L+ F L++
Sbjct: 3142 SMKDRATELQE--QLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKD 3198
Query: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267
E L + +Q + EL L K+ L E+ + + E+ K ++E + + +
Sbjct: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
Query: 2268 LN----EAVAALCGDQEIMKATEQSLDPPIEEEH------QLRNSIEKLRAR---LEADE 2314
LN + L Q+ +++ D + EE Q+ EK+R R D
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
Query: 2315 KKQLCVLQQLKESEHHA-------DLLKGRVENLE----RELEIARTNQEHAALEAENSK 2363
+++L Q + + DLLK + LE R +E+ +++ L++ ++
Sbjct: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY-KLDSLQTR 3377
Query: 2364 GEVE--------TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIIN 2415
++E TL+ + E T+ + + ++S+ E+L +L+++++++ +L++
Sbjct: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
Query: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQ------------------------------- 2444
+ I+QE ++++++ +EK + + Q
Sbjct: 3434 QRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKES 3493
Query: 2445 --TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
+L E+N +++ E + K Q ++S+++ L + ++ LQ ++I +Q +
Sbjct: 3494 NYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3553
Query: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562
++ +I +++ + ++ +S + E+L+ + +++ G E+ +LRN+
Sbjct: 3554 IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMV 3613
Query: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLE----NELELTKMDKMSFVEKVNKMTAKE 2618
++LE++I+ + A ++ + N+E +E E+ +K++ + + + A+
Sbjct: 3614 MKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEV 3673
Query: 2619 TELQREM 2625
+L+ E+
Sbjct: 3674 YKLKAEL 3680
Score = 152 bits (384), Expect = 5e-36
Identities = 281/1418 (19%), Positives = 604/1418 (42%), Gaps = 165/1418 (11%)
Query: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE- 1534
+ S+ +P+S+ + +L EQ + L S + + +A+ CS + CS +
Sbjct: 73 VESTVIPESTIMRTLHSGEITSH--EQGFSVELESEI--STTADDCSSEVNGCSFVMRTG 128
Query: 1535 ---NLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1591
NL R+E GV++ S E Q E MES+ K EI+EL + L
Sbjct: 129 KPTNLLREEE-----FGVDD--SYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1592 RQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLS 1651
R Q L E E ++ + ++ + L +++ ++ E Q Q L +
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 1652 SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD--KDAQQDLNLDIEKI 1709
+ L +T + + D+ + T + + + + + ++D + I +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
Query: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769
E V YE + K + S N+E+I
Sbjct: 302 QEKIKV---------------YEMEQDKKVENS----------------------NKEEI 324
Query: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
+ ++E + + I + ++K L +++ D L + Q++ K + ++
Sbjct: 325 QEKETIIEELNTK-------IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
+ K++ SE+++ +EL +R +D+ ++ ++ + A++
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
++ + ++ + ++ EL IR A +E + ++E + I
Sbjct: 438 DEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEME-----------NALRSYSNITVN 484
Query: 1950 EEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE 2008
E+++ ++ N+L +L DT S+K ++L ++EK L+ + + + + +
Sbjct: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC-ALQRQLEDLVEELSFSREQ 543
Query: 2009 VKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELL 2068
++ + + S ++E K + +++ + S++ + + E ++ + E+L
Sbjct: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603
Query: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128
KE ++ R++ES ++ + + L E +L E H++ IEKL+ +
Sbjct: 604 EKEKNAVLDRMAES--QEAELERLRTQLLFSHEEELSKLKEDLEIEHRI--NIEKLKDNL 659
Query: 2129 EADEKKQL-----HIAEKLKERERENDSLKDKVENLEREL-QMSEENQELVILDAENSKA 2182
K+Q+ +++K++ + E D+L K L E+ ++ + Q LV +E
Sbjct: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL 719
Query: 2183 EVETLKTQIEEMARSLK---VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
++ L+ +IE + + K E ++ L+ + E L KQ++EK+ L E L + S+
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI 779
Query: 2240 L-EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ 2298
L +EK+ E +K + + E L + ++EI E++ D ++ Q
Sbjct: 780 LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK-QQCIQ 838
Query: 2299 LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
L IEK R EK Q+L+ E +A LLK + + LE
Sbjct: 839 LNEEIEKQRNTFSFAEKNFEVNYQELQ--EEYACLLKVKDD-----------------LE 879
Query: 2359 AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
+K E+E K+K++ + + L ++ T++ + + E + E++
Sbjct: 880 DSKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
Query: 2419 ENILQEKE---QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
++++ E +EK+++ ++ S L QLK+ + ++ L+ + ++ K +++ +S +
Sbjct: 939 TELMEKLEVTKREKLELSQRLSD----LSEQLKQKHGEISFLNEEVKSLKQEKEQVS--L 992
Query: 2476 ECLELE------KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529
C ELE +A+ +Q D ++ +L V + E K+ K E S++
Sbjct: 993 RCRELEIIINHNRAENVQSCDTQVSS--LLDGVVTMTSRGAEGSVSKVNKSFGEESKI-- 1048
Query: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL-TVELEQKIQVLQ-SKNASLQDTLEVLQ 2587
++D+ VS + GE K++ L L +L +V E ++ Q S+N LQ L VL+
Sbjct: 1049 MVEDK---VSFENMTVGEES--KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103
Query: 2588 SSYKNLENELELTK----MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
S +L ++E + + + V++V + E E + + + ++ QEE E
Sbjct: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREY--MENEKDKALCSLKEELIFAQEEKIKEL 1161
Query: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL--DCMHKDQVEKEGKVREEIAEYQL 2701
++ +L+L + + + D+ K L L +L+K++ +C + Q +
Sbjct: 1162 QKI-HQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220
Query: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761
++ +K++ + N+ + E+Q YR ++ +E + + LL EE N L
Sbjct: 1221 EVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHT------LLNKVTEEYNKLLV 1272
Query: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA 2821
T+ L ++ + D +K + +EN + L I S Q+ ++I S+L +
Sbjct: 1273 LQTR-LSKIWGQQTDGMKL--EFGEENLPKEETEFLSIHS--QMTNLEDIDVNHKSKLSS 1327
Query: 2822 AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Q+ +K TK++E E++ L +L+++ KE ++
Sbjct: 1328 LQDLEK------TKLEEQVQELESLISSLQQQLKETEQ 1359
Score = 145 bits (365), Expect = 8e-34
Identities = 218/1095 (19%), Positives = 473/1095 (43%), Gaps = 170/1095 (15%)
Query: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA---------DKSSREDIGDNVAK 1888
E+ + +KLE + QR S+G + + D S+ D+ + ++
Sbjct: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61
Query: 1889 VNDSWKERFLDVENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN-- 1939
N+ + VE+ + + S + + + +E + E+ T C + N
Sbjct: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121
Query: 1940 ----ENKQKVIVCLEEELSVVTSERNQLRGELDT-MSKKTTALDQLSEKMKEKTQELE-- 1992
+ + EEE V S Q + T + + L +++E +ELE
Sbjct: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1993 --SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
++ +E L +Q EA +K++ ++ L++++ + ++K + L + SQ L +
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 2051 KCELE-----------NQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKALEAAL 2097
+L+ + A L + K+ ++ + L Q L E DY+K ++ +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE-DYQKKKEDFTMQISF 300
Query: 2098 VEKGEFALRL-------SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
+++ + +S +EE+ + IE+L +I +EKK L + +KL ++
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 2151 SLKDKVENLERELQMSEENQELVILDAE----NSKAEVETLKTQIEEMAR---SLKVFEL 2203
L++++ +E+ +N +L + +++ S E++ L +EE+ + FE
Sbjct: 361 ELQEQIVQKNQEI----KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 2204 DLVTLRSEKENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ 2262
D+V + + ++ Q K QL +ELD++ Q +Q+K+ E+++
Sbjct: 417 DIV------QRMEQETQRKLEQLRAELDEMYG----------QQIVQMKQ------ELIR 454
Query: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
+ ++ E G+ E + ++ ++ + +I +L +L+ ++ + +
Sbjct: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE 514
Query: 2323 QLKESEHHADLLKGRVENLERELEIAR----------TNQEHAALEAENSKGEVETLKAK 2372
+L L+ ++E+L EL +R QE EA S VE LKA+
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
Query: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-- 2430
I ++S + LEL E E+ N + + EKE+ V
Sbjct: 575 IVSASESRKELELK----------------------HEAEVTNYKIKLEMLEKEKNAVLD 612
Query: 2431 QMKEKSSTAMEMLQTQLK-ELNERVAALHNDQEA-----CKAKEQNL----SSQVECLEL 2480
+M E +E L+TQL E ++ L D E + + NL Q++ L+
Sbjct: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 672
Query: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-EKKDEEISRLKNQIQDQEQLVS 2539
E +Q ++ + K+N I Q+ + I +++D +Q L K EE++ N++Q + +++
Sbjct: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
Query: 2540 KLSQVEGE-HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
+ + +G Q +E L+ L ++++K LQ K A L+ +L+ K LE+ L+
Sbjct: 733 QEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK 792
Query: 2599 L----TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
+ ++ +++ F++ + K +K++ ++E+ + ++ +L+++ L
Sbjct: 793 IHTPVSQEERLIFLDSI-KSKSKDSVWEKEIEILIEENEDLKQQCI-----------QLN 840
Query: 2655 EEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA-EKK 2709
EEI+ ++ K + EL++ C+ K + + E ++ EY+ +L E+
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
H + T + + + +++ ++ LE+ + K TT+++E+
Sbjct: 901 HLQRINPTTVK-------MKSSVFDEDKTFVAETLEMGEVVE---------KDTTELMEK 944
Query: 2770 LKKTKMDNLKY---VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
L+ TK + L+ ++ L ++ ++ G++ L + K L++EKE + +L+
Sbjct: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
Query: 2827 KTGTVM--DTKVDEL 2839
+ V DT+V L
Sbjct: 1005 RAENVQSCDTQVSSL 1019
Score = 144 bits (362), Expect = 2e-33
Identities = 314/1576 (19%), Positives = 651/1576 (41%), Gaps = 222/1576 (14%)
Query: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
L KE + A Q+L + +KL KEK + Q Q + + LQKQ + +E + E +
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
Query: 65 L-----KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119
+ +N LM++ + + ++++ + + Q +E + + +++I+KLEQ+LK
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
+ R Q ++ + K T + D++E+ N+E+E
Sbjct: 2096 ----VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER-NEEIE--- 2147
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL--SSNSQRTPI 237
+LE V+ L+ QA + D + F + K L ++R I
Sbjct: 2148 KLEFRVRELE---------QALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
Query: 238 RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
R E+E+T L+ + + + N L QL+ Q +E ++ EL
Sbjct: 2199 DRK--------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 298 ELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTK 356
E+E K + ++L L ++++ + + VL K + + DQ + +
Sbjct: 2248 -------EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300
Query: 357 YTALEQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKE---KEFQEELSRQQRSFQTLD 411
T L+Q+LK T++ + +N +E + ++E + +EE+ + + L
Sbjct: 2301 VTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360
Query: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
QE + + + + L+ +LD + + K LE +E +++ + + +
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420
Query: 472 IKENELRRSMEEMKKE-----------NNLLKSHSEQKAREVCHLEAELKN--IKQCLNQ 518
K N+L + + +K+E N + + +++ LE L +K NQ
Sbjct: 2421 FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2480
Query: 519 S--QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKK 576
+ ++F E K + ET L L+ ++ ++ L L + + D+++Q ++L+K
Sbjct: 2481 TYFKSFEENGKGSIINLETRLLQLESTVSAKD--LELTQCYKQIKDMQEQGQFETEMLQK 2538
Query: 577 REHHIEQLNDKLSKTEKESKALLSALELKK-KEYEEL-KEEKTLFSCWKSENEKLLTQME 634
+ +++++ + EK + AL+S ++L+ +EY + ++ +T+ S + N + L Q+
Sbjct: 2539 KIVNLQKIVE-----EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL- 2592
Query: 635 SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE 694
++ L S I+ L L+ +++S + E +L +++E + + + NVL+ + +E
Sbjct: 2593 -REDELGSDISAL--TLRISELES-QVVEMHTSLILEKEQVEIAEK---NVLEKEKKLLE 2645
Query: 695 TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED-LEHKLQLLSNEIMDKDRCY 753
QKL +++ E ++ +++E + T E ++L+ L E +
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
Query: 754 QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE 813
+ E L++ L K+ ++ + Q+ L A +I+ ++ + S+
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTS---LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESK 2762
Query: 814 --CRLEADQSPKNSAILQNRVDSLEFSLESQKQ--------MNSDLQKQC--EELVQIKG 861
C E + +I +L+ S +Q + +LQ +C EE+ +I
Sbjct: 2763 KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS 2822
Query: 862 EIEENLMKAEQMHQSFVAE-TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKV 920
+ E + K +++H + + + S+ IS+ + H V + +Q L K
Sbjct: 2823 QFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK- 2881
Query: 921 ETEQAEIQELKKSNHLLEDSLKELQLLS--------ETLSLEKKEMSSIISLNKREIEEL 972
E + I EL S D+ + ++ S + + L + I S + E E
Sbjct: 2882 --EGSSIPELAHS-----DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2934
Query: 973 TQEN--GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK-------- 1022
++ +K + +++ E M ++ +ES Y D + SI ++S+ + +E+
Sbjct: 2935 ATDSFPKKIKGLLRAVHNEGMQVLSLTES--PYSDGEDHSIQQVSEPWLEERKAYINTIS 2992
Query: 1023 ----LILLQRCEETGNAYEDLSQKYKAAQEKNSKL-----ECLLNECTSLCENRKNELEQ 1073
LI + + Y D SQ +++ + +L + L E + L + EL
Sbjct: 2993 SLKDLITKMQLQREAEVY-DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051
Query: 1074 LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133
L A L + +E+ +E +Q+A R + ++ G K +
Sbjct: 3052 LGTTDAVGLLNCLEQR--IQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK---I 3106
Query: 1134 TLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE-RNQCNFKP 1192
TLK EQ + +K +LL+ N Q + + Q LE + +S+K+R +E + Q + +
Sbjct: 3107 TLKREQ-ESEKPSQELLEYNIQ-------QKQSQMLEMQVELSSMKDRATELQEQLSSEK 3158
Query: 1193 QMDLEVK----------EISLDSYNAQLVQLEAM-----------------LRNKELKLQ 1225
+ E+K E +L + + L +LEA L +++ K +
Sbjct: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR 3218
Query: 1226 E----SEKEKECL-------QHELQTIRGDLETSNLQDMQ-----SQEISGLKDCEIDAE 1269
E EKEK L + EL+ ++ LE+ +++Q Q+ L + + E
Sbjct: 3219 ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE 3278
Query: 1270 EKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECI 1329
+ + +LS Q N LQ L++ ++ E+ + + +L + +S
Sbjct: 3279 SQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3338
Query: 1330 TATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNS 1389
+ + +E+ K L E H +VE + NE L L
Sbjct: 3339 LPSEDLLKELQKQLEE----------KHSRIVELL---------NETEKYKLDSLQTRQQ 3379
Query: 1390 YEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
E K+ Q+H LQ + + K +H ++ SK+ +LQ ++ + + L
Sbjct: 3380 ME------KDRQVHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKL 3429
Query: 1450 STNLRNFQGDLVKEMQ 1465
+ QG +++E Q
Sbjct: 3430 DLEGQRLQG-IMQEFQ 3444
Score = 91.3 bits (225), Expect = 1e-17
Identities = 130/584 (22%), Positives = 263/584 (45%), Gaps = 71/584 (12%)
Query: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL--ELDVVTIRSE 2393
G+ NL RE E + ++ A++S +E +++++ G + L EL+ + +
Sbjct: 128 GKPTNLLREEEFG-VDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186
Query: 2394 KENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKE--KSSTAMEMLQTQLKEL 2450
E L +LQ+ + I + + II N+ Q + ++ M+E + + + LQ Q ++L
Sbjct: 187 TEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
Query: 2451 NERVA---ALHNDQEA--CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
+ H+ A +AK+Q L+ Q + LE E+ LL+ + K ++ + ++
Sbjct: 246 QASETLRNSTHSSTAADLLQAKQQILTHQQQ-LE-EQDHLLEDYQKKKEDFTM---QISF 300
Query: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL 2565
L ++++ + + +KK E + K +IQ++E ++ +L+ + +E T+EL
Sbjct: 301 LQEKIKVYEMEQDKKVENSN--KEEIQEKETIIEELNT----------KIIEEEKKTLEL 348
Query: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
+ K+ LQ+ + KN++ EL +K + E++ ++ ELQ+
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK--DQLKELTLENSELKKSLDCMHK 2683
H+ +Q ++ + + E R +L+ L+E+ + +EL ++ + + HK
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 2684 DQVEKEGKVREEIA--EYQLRL-HEAEKKHQALLLDTNKQYEVEIQTYREK--LTSKEEC 2738
++E + I E Q++L + A + L DTN Q E +E+ L +E+C
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE----KLKEELGLILEEKC 524
Query: 2739 LSSQKLE--IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
++LE ++ L S+E++ + + + +L + +L V LK E A K
Sbjct: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASESRK 583
Query: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
L +L+ E E+ ++ +EK V+D + E++ L+
Sbjct: 584 EL-----ELKHEAEVTNYKIKLEMLEKEK---NAVLDRMAESQEAELERLR--------- 626
Query: 2857 ADEYLDKYCSLLISH-EKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
LL SH E+L K KE LE + H + + +D+ G
Sbjct: 627 --------TQLLFSHEEELSKLKEDLE--IEHRINIEKLKDNLG 660
Score = 48.9 bits (115), Expect = 8e-05
Identities = 124/624 (19%), Positives = 262/624 (41%), Gaps = 88/624 (14%)
Query: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICESLE 80
E++ +L +K + Q QL S + + + K ++ K E T LK +++ L E+
Sbjct: 3135 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL----- 3189
Query: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ--AAQSADVS 138
+ E++ K +V+ L S +K+ +L+ L++ K++L RS++ + D+
Sbjct: 3190 ---EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3246
Query: 139 LNPCNTPQKIFTTPLTPSQY-----YSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKK 192
+ + Q+ L Q S K E + Y+ ++ E + E++ L+++K
Sbjct: 3247 FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEK 3306
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQ------------------QEKTPSHLSSNSQR 234
+T++ Q SS + Q +EK + ++
Sbjct: 3307 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET 3366
Query: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL----DQLKAQNQEL 290
+ D + E++ R TLQ +++AN+ + H L + L+ Q +E
Sbjct: 3367 EKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANT---EGQKKMHELQSKVEDLQRQLEEK 3422
Query: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
R ++ +L+L Q ++G + +FQ+ +L+ E+ + E ++L + +E TT
Sbjct: 3423 RQQVYKLDLEGQ----RLQGIMQEFQKQELEREEKR----ESRRILYQNLNE--PTTWSL 3472
Query: 351 DQASTKYTALEQKLKKLTEDLSCQR---QNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
T+ L+QK++ T++ + + N C+ E E+ RQ+
Sbjct: 3473 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL-----------EMIRQKLQC 3521
Query: 408 QTLDQECIQMKARLTQELQQAKNMHNV-LQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
+ + KA + + A + + +Q +D++ Q+L E + +
Sbjct: 3522 VASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSC 3581
Query: 467 FQASQ--IKEN-ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
++ +++N EL + ++ +E N L++ V LE +++ +Q N +
Sbjct: 3582 GSLTERLLRQNAELTGHISQLTEEKNDLRN-------MVMKLEEQIRWYRQTGAGRDNSS 3634
Query: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQR------DCSQDLLKK 576
+ E ++ +E N+++ LTL+K LK A A++ K + Q L
Sbjct: 3635 RFSLNGGANIEAIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3692
Query: 577 REH-HIEQLNDKLSKTEKESKALL 599
EH ++++ K + E KAL+
Sbjct: 3693 SEHVTLKRIYGKYLRAESFRKALI 3716
Score = 48.9 bits (115), Expect = 8e-05
Identities = 101/531 (19%), Positives = 208/531 (39%), Gaps = 88/531 (16%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
+ WALE+ K KL + +++ + +L+ L+ +L+ QKQ +
Sbjct: 3220 LQWALEKEKA------------------KLGRSEERDKEELEDLKFSLESQKQ-----RN 3256
Query: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
NL E Q+ + L +++QKI + + ++Q++ ++G+ + +E + ++
Sbjct: 3257 LQLNLLLEQQK-----QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
Query: 121 CKSELERSQQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE- 176
S L+R ++ QS+D T Q + P PS+ + L+EK+++ VE
Sbjct: 3312 MSSTLDRERELHAQLQSSD------GTGQ---SRPPLPSEDLLKELQKQLEEKHSRIVEL 3362
Query: 177 ----ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
E+ +L++ ++ Q + + + + T+ A + + Q +
Sbjct: 3363 LNETEKYKLDS-LQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3421
Query: 233 QRTPI-RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
+R + + D G + + + KR++ + N + P + R
Sbjct: 3422 KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP---TTWSLTSDRTR 3478
Query: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
N + L+ +++G KE +LIE C EL +
Sbjct: 3479 NWV--LQQKIEGETKESN----------------YAKLIEMNGGGTGCNHELEMIRQKLQ 3520
Query: 352 QASTKYTALEQKLKKL-------TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
++K L QK + ED ++N + L QK+ ++ E + L
Sbjct: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-QKLTGQQGE-EPSLVSPS 3578
Query: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464
S +L + ++ A LT + Q L E + L ++ +LE + ++Q +
Sbjct: 3579 TSCGSLTERLLRQNAELTGHISQ-------LTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
Query: 465 QAFQAS----QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511
+ + S E + E +E L+ ++ EV L+AEL+N
Sbjct: 3632 NSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 284 bits (727), Expect = 8e-76
Identities = 490/2297 (21%), Positives = 968/2297 (42%), Gaps = 372/2297 (16%)
Query: 729 TGQVEDLEHKLQLL--SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
+G + KLQL S E + + + L S L+++ + D S +
Sbjct: 55 SGDTQSFAQKLQLRVPSVESLFRSPIKESLFRS-SSKESLVRTSSRESLNRLDLDSSTAS 113
Query: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
FD M +++G S+ E+ L R+ +E SL S +
Sbjct: 114 FDPPSDMDSEAEDLVGNSDSLNKEQ----------------LIQRLRRMERSLSSYRGKY 157
Query: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL 906
S+L + L + K +++ L +++ +AE + +LQ D A +++ E ++L
Sbjct: 158 SELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELRE---ELQMDQQAKKHLQEEFDASL 214
Query: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS------- 959
E K++ + +L +T+ + +++ ++ + D LK L L + KE +
Sbjct: 215 EEKDQYISVL----QTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEP 270
Query: 960 ------SIISLNKREIEELTQENGTLKEINASLNQEKMN---LIQKSESFANYIDEREKS 1010
S+ +L + QEN LK ++ K L + E+ +DER +
Sbjct: 271 VVEDGTSVKTLETLQQRVKRQEN-LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQE 329
Query: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKY-----KAAQEKNSKLECLLNECTSLCE 1065
+ ++ D + EK L+ + + N E L Q + ++ + LE E L
Sbjct: 330 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Query: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAE-ERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
K Q +E +E +E + AF E E+ + + E ++ L++EM + +
Sbjct: 390 RIKQMTTQGEEL--REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
Query: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQEN--EQLMKVMKTKHECQNLESEPIRNSVKERE 1182
+ ++E ++L++E +++++EV D+++++ EQ+ K+ K + + + + ++ RE
Sbjct: 448 S---EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE 504
Query: 1183 SERNQCNFKPQMDL-------EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
E F+ QM + E +IS + + + LE + K+ L ESE + LQ
Sbjct: 505 RE-----FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 1236 HELQTIRG---DLETS---NLQDM--QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA 1287
E +T R +LE+S +LQ+ QS++++ + E + K I+ E ++ ++
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 1288 -HLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1346
H Q +L T E LQ K + TE+ R +C +E LL +
Sbjct: 620 KHQQDALWT------------EKLQVLKQQYQTEMEKLREKC-------EQEKETLLKDK 660
Query: 1347 KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLD-ESNSYEHLTLSDKEVQMHFA 1405
+I+ F E + +L LD + E L+ EV
Sbjct: 661 EII-------------------FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH 701
Query: 1406 ELQEKFLSLQSE-HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEM 1464
+L+E+ L+ + K+ + +M + + Q VDS+ E+ V D + ++
Sbjct: 702 KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
Query: 1465 QLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVD 1524
+L L+E L + + LE + EG + +D
Sbjct: 762 ELLLKE---------------RDKHLKEHQAHVENLEAD-----IKRSEGELQQASAKLD 801
Query: 1525 EVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM---ESQGIMKNKEI 1581
VF S ++ T ++T + Y + L +L++K+ E++ I+ K++
Sbjct: 802 -VFQSY---QSATHEQT---------------KAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 1582 QELEQLLSSERQELDC-------LRKQYLSENEQWQQKLTSVTLEMESKLA---AEKKQT 1631
E+E ELD L +Q +N + +QK+ S+T ESKL E++QT
Sbjct: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT 902
Query: 1632 EQLSLELEVARLQLQG-----LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTP 1686
+Q+ +E E LQ++ +++ ++ L ED+I NE + ++ + E+
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQKLSA--KEDSIHILNEEYETKFKNQEKKMEKVK 960
Query: 1687 -KHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSEC 1745
K Q K D ++K E A++ + + E+ + + + G S+
Sbjct: 961 QKAKEMQETLKKKLLDQEAKLKKELENTALELSQK---EKQFNAKMLEMAQANSAGISDA 1017
Query: 1746 ISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
+S L + +E I +L T L VI ++K+ E++
Sbjct: 1018 VSRLETN------------QKEQIESL------TEVHRRELNDVISIWEKKLNQQAEELQ 1059
Query: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE--TS 1863
E+ E+QL K ++E ++L +K+ F C+ +E+ + +
Sbjct: 1060 EI------HEIQLQEK--------------EQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 1864 EGLNSDL---EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
EG+ D E+ + +++A+ K +E +L++ E ++ + +
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL 1980
L+ E E+K+KV L +L E L+ + +K +L+
Sbjct: 1160 LKMLAE-------------EDKRKVSE-LTSKLKTTDEEFQSLKSSHEKSNK---SLEDK 1202
Query: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKT-ELLQTLSSDVSELLKDKTHLQEKLQS 2039
S + K+ ++EL C + EA ++ KT EL+ SS + +L +H Q +
Sbjct: 1203 SLEFKKLSEELAIQLDICC---KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 2040 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2099
+++ + T ELE Q+ QL +E+ L + +L E + + ++ +E+ + E
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 2100 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2159
K + Q+ + I +L+ + + + E+LKE++ E SL ++ +L
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Query: 2160 ERELQ----MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
+LQ +SE+ + L + + + E L Q+++++ F++D TL EK +
Sbjct: 1380 NVQLQNSISLSEKEAAISSLRKQYDEEKCELL-DQVQDLS-----FKVD--TLSKEKISA 1431
Query: 2216 TKQIQEKQGQLSELDKLLSS-FKSLLEEKEQAEIQIKEESKTAVE------MLQNQLKEL 2268
+Q+ + + SE K S F ++ +IQ++ +SK A E +L+ +L +
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 2269 NEAVAALCGDQEIMKATEQSLDPPIE-------------EEHQLRNSIE----------- 2304
N+ L G+ E K+ + + +E E+H + +IE
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 2305 -------------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
KL+ E E+K ++KE+E L+ +V +++ ELE +
Sbjct: 1552 NQQKDIEHKELVQKLQHFQELGEEKD----NRVKEAEEKILTLENQVYSMKAELETKKKE 1607
Query: 2352 QEHAALEAENSKGEVETLKAKIEG-----MTQSLRGLELDVVTIRSEKENLTNELQKEQE 2406
EH L ++ + E++ L+ ++E + + R E + I+ K+ L+ +KE++
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK--KQLLSQMEEKEEQ 1665
Query: 2407 RISELEIINSSFENILQEKEQEKVQMKEK-SSTAMEMLQTQLKELNERVAALHNDQEACK 2465
E S LQE+E+E ++EK S +T + + + A + +QE
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
Query: 2466 AK---EQNLSSQVECLE---LEKAQLLQGLDEAKNNYIVLQSSVNGLIQE----VEDGKQ 2515
++ ++ ++ L+ EK +LLQ + + K + + QE +E +
Sbjct: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 2516 KLEKKDEEISRLKNQIQDQEQLVSKL--SQVE---GEHQLWKEQNLE-----LRNLTVEL 2565
K + I L+ +++++ + S + VE G++ + +QNLE ++ E
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
E Q+L+ K L D+ V Q +E E +K +K+ +++++ K TEL E
Sbjct: 1846 ELTCQILEQKIKEL-DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN-KPTELLEEN 1903
Query: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL--------KELTLENSELKKS 2677
E K+ +Q +L +L+ L + K +L K+L + E ++
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963
Query: 2678 LDCMHKD-QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL--TS 2734
L+ + K+ E+E K+++E + +L KH + L +++ ++ ++L T
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLEL-------KHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Query: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGK 2794
KE +Q++E +LL+S +EE N LK + ++LK+T +Y L E K
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK---RYEEILDAREEEMTAK 2073
Query: 2795 MKLLIKSCKQLEEEKEILQKELSQLQ------------AAQEKQKTGTVMDTKVDELTTE 2842
++ L QLEE ++ Q++L Q + Q QKT + D+K+ E E
Sbjct: 2074 VRDL---QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE--QE 2128
Query: 2843 IKELKETLEEKTKEADE 2859
+E LE++ K+ ++
Sbjct: 2129 FREQIHNLEDRLKKYEK 2145
Score = 244 bits (623), Expect = 1e-63
Identities = 477/2351 (20%), Positives = 979/2351 (41%), Gaps = 321/2351 (13%)
Query: 220 QQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRST---------LQIGKRDANSSF 270
QQ P+ SSNS R ++S+ E TP+R + LQ+ S F
Sbjct: 17 QQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLF 76
Query: 271 FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI 330
S L + ++ +R E RL + + + + +
Sbjct: 77 --RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSL 134
Query: 331 EKEKVLNKCR---DELVRTTAQYDQASTKYTALEQKLKKL------TEDLSCQRQNAESA 381
KE+++ + R L +Y + T Y L+++ KKL ++D S +R
Sbjct: 135 NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELRE 194
Query: 382 RCSLEQKIKEK-EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD 440
++Q+ K+ ++EF L + + L + +K RL + + Q E
Sbjct: 195 ELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ 254
Query: 441 KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR 500
K E N E + + + + + + ++R +K+ ++SH EQ
Sbjct: 255 AEVFTK---EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
Query: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560
EA + + + L + + + A+ T T LRD + I Q E + + +
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE-----QDKGMVI 366
Query: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK-EYEELKEEKTLF 619
A+ ++Q + L+ +E I QL ++ + + + L E ++ +EEL EK L
Sbjct: 367 AETKRQ---MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL--EKALS 421
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
+ K+E + + E +++ + E + QQ S E V ++ E ++
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 680 RNLHNVLDSKSVEVETQKL--AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE- 736
+ LH ++ + T+KL E Q++ + + +K Q E LK SQ Q E L
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY----LKISQEKEQQESLAL 537
Query: 737 HKLQLLSNEIM-DKDRCYQDLHAEYESLR----DLLKSKDASLVTNEDHQRSL-LAFDQQ 790
+L+L I+ + + +DL E E+ R +L S + SL N++ + L + + +
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQ 850
H+ ++ E+ E + + +A + K + Q ++ E +K L+
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ------QYQTEMEK-----LR 646
Query: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
++CE+ E E L E + Q+ + E +++ TL L+ K+
Sbjct: 647 EKCEQ------EKETLLKDKEIIFQAHIEEMNEK-----------------TLEKLDVKQ 683
Query: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970
EL+ L+ +E+ E+ K+ H LE+ EL +L + K+E+ + +++
Sbjct: 684 TELESLS-------SELSEVLKARHKLEE---ELSVLKDQTDKMKQELEA-------KMD 726
Query: 971 ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE 1030
E Q+N +++++ + + ++++ + ++ + I++ E + E K+ +
Sbjct: 727 E--QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ-------A 777
Query: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
N D+ + Q+ ++KL+ + ++ E K EQL +
Sbjct: 778 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL------------- 824
Query: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Q +L+LET + L ++ + + K L + +++ +++K+ +++
Sbjct: 825 ------QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878
Query: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL----DSY 1206
Q+ + L +V ++K E N E E + + E+E+ Q + ++E+ L DS
Sbjct: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
Query: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
+ + E +N+E K+++ +++ + +Q L+ D E +++++ + E+
Sbjct: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL------EL 992
Query: 1267 DAEEKYISGPHELSTSQNDNAHLQCSL-QTTMNKLNELEKICEILQAEKYELVT----EL 1321
+EK + L +Q ++A + ++ + N+ ++E + E+ + E ++++ +L
Sbjct: 993 SQKEKQFNA-KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 1322 NDSRSEC----ITATRKMAEEVGKLLNEVKILNDDSGLLHGELV--------EDIPGGEF 1369
N E ++ +EV +L ++ + + ++ E+ +D E
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
Query: 1370 GEQPNEQ--HPVSLAPLDESNSYEHLTLSDKEVQMHFAE---LQEKFLSLQSEHKILHDQ 1424
EQ ++ H SLA DE+ HL + ++ E LQE+ + L+ + +
Sbjct: 1112 QEQLKQKSAHVNSLAQ-DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
Query: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDS 1484
+++SK+ SLK+ + + +L + + K L E L L C
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK-----LSEELAIQLDICCKKTE 1225
Query: 1485 SSLSSLGD------SSFYRALLEQTGD-MSLLSNLEGAVSANQCSVDEVFCS--SLQEEN 1535
+ L + + SS A+L + + ++ A+ C+V E+ L EE
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 1536 LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL 1595
T + +EE E+ + + +E L E + + K Q Q +SE++
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESL--VTEKEALQKEGGNQ---QQAASEKESC 1340
Query: 1596 DCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655
K+ LSEN + +VTL M+ +L +K + LS +L +QLQ S+
Sbjct: 1341 ITQLKKELSEN------INAVTL-MKEELKEKKVEISSLSKQLTDLNVQLQ------NSI 1387
Query: 1656 LGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT--ETG 1713
+ E AI + K++ E E D QDL+ ++ ++ +
Sbjct: 1388 SLSEKEAAIS------SLRKQYDEEKCELL-----------DQVQDLSFKVDTLSKEKIS 1430
Query: 1714 AVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQ 1773
A++ + S + S ++ + + + EL L+
Sbjct: 1431 ALEQVDDWSNKFS---EWKKKAQSRFTQHQNTVKELQI-------------------QLE 1468
Query: 1774 LRVKET--SNENLRLL-HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA----CI 1826
L+ KE +E + LL ++ ++++ + L EM++ SK+ +E L T++++ +
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 1827 ELEKIVGELKKENSDLSEKLEYFS----CDHQELLQRVETSEGLNSDLEMHADKSSREDI 1882
ELE + + E L+E L+ ++ +H+EL+Q+++ + L + + ++
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEA----- 1583
Query: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942
+E+ L +EN++ +++E + + E ++ ++ + E LE
Sbjct: 1584 -----------EEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR---- 1628
Query: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
LE E + +E + + E + K L Q+ EK ++ + ESH SE +
Sbjct: 1629 ------LESESAAKLAELKR-KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 2003 QVAEAEVKEKTELLQTLSSDVSELL---KDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Q E EV E L+++ S SE L + ++ + E DSQ E + +
Sbjct: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
Query: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Q N + E E L R+ + E ++ + E+ ++L + + H+ +
Sbjct: 1742 QRN------LTEKEKLLQRVGQEKEETVSSHFEMRCQYQER---LIKLEHAEAKQHEDQS 1792
Query: 2120 GIEKLRVRIEADEKK-QLHIAEKL-KERERENDSLKDKVENLERELQMSEENQELVILDA 2177
I L+ +E KK L +A+ + KE + N K +EN+ ++Q + + +EL
Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
Query: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI--QEKQGQLSELDKLLSS 2235
E E+++ + +E+ R E++ +T + EK +Q+ + K +L E + S
Sbjct: 1853 EQKIKELDSCLVRQKEVHR----VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
Query: 2236 FKSLLEEKEQAEIQIK-EESKTAVEMLQNQLKELNEAVAALCGDQEIM-KATEQSLDPPI 2293
L++ K + ++ + + + + + + ++L + + L D ++ K +Q L+
Sbjct: 1909 KSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
Query: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
+E Q R EK++ E E K L+QL ++ E+ELE+
Sbjct: 1969 KEYDQERE--EKIKQEQEDLELKHNSTLKQLMRE------FNTQLAQKEQELEMTIKETI 2020
Query: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGL-ELDVVTIRSEKENLTNELQKEQERISELE 2412
+ A E E E L++ E Q L+ + E D R+ K +E+E +++
Sbjct: 2021 NKAQEV-----EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVR 2075
Query: 2413 IINSSFENILQEKEQEKVQMKEK----SSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
+ + E LQ+K Q+K++ +E + T ME LQTQL + ++ K KE
Sbjct: 2076 DLQTQLEE-LQKKYQQKLEQEENPGNDNVTIME-LQTQLAQKTTLIS-------DSKLKE 2126
Query: 2469 QNLSSQVECLE 2479
Q Q+ LE
Sbjct: 2127 QEFREQIHNLE 2137
Score = 239 bits (610), Expect = 3e-62
Identities = 458/2267 (20%), Positives = 951/2267 (41%), Gaps = 370/2267 (16%)
Query: 519 SQNFAEEMKAKNTSQETMLRD----------LQEKINQQENSLTLEKLKL--AVADLEKQ 566
+Q+FA++++ + S E++ R +E + + + +L +L L + A +
Sbjct: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117
Query: 567 RDC---SQDLLKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEEL-KEEKTLFSC 621
D ++DL+ + + EQL +L + E+ + Y+ L +E+K L
Sbjct: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
Query: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV---E 678
+K L ++ +E LQ QQ K H E +LE + +SV +
Sbjct: 178 LSQSQDKSLRRIAELREELQMD----------QQAKKHLQEEFDASLEEKDQYISVLQTQ 227
Query: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAE-FSDQKHQKEIENMCLKTSQLTGQVEDLEH 737
+ L L + + V+ K +L+ +AE F+ +++ + ++ +E L+
Sbjct: 228 VSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
Query: 738 KLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 797
+++ N + RC + + + E L K+A E L ++ +H
Sbjct: 287 RVKRQENLLK---RCKETIQSHKEQCTLLTSEKEA---LQEQLDERLQELEKIKDLH--- 337
Query: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
+ E+ + ++ + + +Q ++ ++ E+++QM+ L+ + EE+
Sbjct: 338 ---MAEKTKLITQLRDAKNLIEQLEQDKGMV---------IAETKRQMHETLEMKEEEIA 385
Query: 858 QIKGEIEENLMKAEQMHQ-------SFVAETSQRISKLQEDTSAHQNVVAETLSALE--- 907
Q++ I++ + E++ + + E + +S Q+ A + + AE ++
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Query: 908 --NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSE-TLSLEKKEMSSIISL 964
++E+ + L + +Q + +KKS+ E+ + +LQ L E L+ +++E++ +
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSS---EEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 965 NKREIEELTQ------ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
+RE +E + ++ LK QE + L + + E E + +L +
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 1019 KQEKLILLQ-------RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL 1071
+ + +L+ +E N +DL+ +A + K++K E T + E K EL
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK------EITVMVEKHKTEL 616
Query: 1072 EQLK-----------EAFAKEHQEFLTKL-AFAEERNQNLMLELETVQQALRSEMTDNQ- 1118
E LK + +++Q + KL E+ + L+ + E + QA EM +
Sbjct: 617 ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 1119 ---NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPI 1174
+ ++E L E+ + + ++K+++E++ L + +++ + ++ K E +N + +
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 1175 RNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECL 1234
+ +KE E + ++ E +L Q+ QLE +L+ ++ L+E + E L
Sbjct: 737 DSIIKEHE-----------VSIQRTEKALKD---QINQLELLLKERDKHLKEHQAHVENL 782
Query: 1235 QHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN-AHLQCSL 1293
+ +++ G+L+ ++ ++D + Y S HE + + + A LQ L
Sbjct: 783 EADIKRSEGELQQAS--------------AKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 1294 QTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353
+ L K ++A+K ++ TEL+ + + +++ ++ ++ +VK L
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ-- 886
Query: 1354 GLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLS 1413
++ +ED G + EQ L E++ L +E Q E+ + LS
Sbjct: 887 --VYESKLED------GNKEQEQTKQILV------EKENMILQMREGQKKEIEILTQKLS 932
Query: 1414 LQSE--HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEG 1471
+ + H + + + ++ +++ K L L + + L KE++
Sbjct: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE------ 986
Query: 1472 LVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSL 1531
+++ S + F +LE AN + +
Sbjct: 987 -----------NTALELSQKEKQFNAKMLEM-------------AQANSAGISDA----- 1017
Query: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL-LSS 1590
++R ET E++ESL EV+R+ L + E + + +E+QE+ ++ L
Sbjct: 1018 ----VSRLETNQK-----EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQE 1068
Query: 1591 ERQELDCLRKQYL---SENEQWQQKLT---------SVTL-EMESKLAAEKKQTEQLSLE 1637
+ QE+ L+++ L E E+ +++T TL E++ +L + L+ +
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 1638 LEVARLQLQGLDLSSRSLLGIDT--EDAIQGRNESCDISKEHTSETTERTPKHD------ 1689
+ L+ L++ L +T ++ + + K SE T + D
Sbjct: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188
Query: 1690 --VHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE----QSPDTNYEPPGEDKTQGSS 1743
H+ +K + +D +L+ +K++E A++ C ++ KT
Sbjct: 1189 KSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247
Query: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL-------LHVIEDRDRK 1796
IS V L + L+ ++++ + E L H +E+++ +
Sbjct: 1248 SRISHCQHR--TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ 1305
Query: 1797 VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL 1856
++S+ +++ L ++ + + + +A E E + +LKKE LSE + + +EL
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE---LSENINAVTLMKEEL 1362
Query: 1857 LQ-RVETSE------GLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELS---- 1905
+ +VE S LN L+ S +E ++ K D K LD +LS
Sbjct: 1363 KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVD 1422
Query: 1906 RIRSEKAS-----------------------IEHEALYLEADLEVVQTEKLCLEKDNENK 1942
+ EK S +H+ E +++ K EKD +
Sbjct: 1423 TLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ-- 1480
Query: 1943 QKVIVCLEEELSVVTSERNQLRGELD----TMSKKTTALDQLSEKMKEKTQELESHQSEC 1998
I L+EEL + L+GE++ M KK + L+ + + ELE H
Sbjct: 1481 ---INLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH---- 1533
Query: 1999 LHCIQVAEAEVKEKTELLQTLSS----DVSELLKDKTHLQEKLQSLEKDSQALSLTK--C 2052
I E++ E+L+ + + EL++ H QE + EKD++ +
Sbjct: 1534 ---ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE--EKDNRVKEAEEKIL 1588
Query: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQE 2112
LENQ+ + E E KE E + + + E KALE L + E A +L+ +
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEE----LKALEDRL--ESESAAKLAELKR 1642
Query: 2113 EVHQLRRGIEK-LRVRIEADEKK-----QLHIAE---KLKERERENDSLKDKVENLEREL 2163
+ Q I+K L ++E E++ + H++E KL+ERERE L++K++++E
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE--- 1699
Query: 2164 QMSEENQELVI-LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR---SEKENLTKQI 2219
S +++ L++ A+N A E + + + K +E + L+ +EKE L +++
Sbjct: 1700 --SSQSETLIVPRSAKNVAAYTE--QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Query: 2220 -QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
QEK+ +S ++ ++ L + E AE + + E ++ + LQ +L+E N+ + +
Sbjct: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHAEAK-QHEDQSMIGHLQEELEEKNKKYSLIVA- 1813
Query: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE---------H 2329
Q + K ++ I+ + L N + ++ L+ E + Q++KE + H
Sbjct: 1814 QHVEKEGGKN---NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 2330 HADL--LKGRVENLERELEIARTNQEHAALE---AENSKGEVETLKAKIEGMTQSLRGLE 2384
++ L + E L+ ++ N+ LE E SK + K + M LE
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKL-LSNMEAQHNDLE 1929
Query: 2385 LDVVTIRSEKENLTNE---LQKE-----QERISELEIINSSFENILQEK---EQEKVQMK 2433
+ EK+ L E LQK+ +E ELEI+ ++ +EK EQE +++K
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 2434 EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
S+ L+ ++E N ++A + E + N + +VE A+LL+ E
Sbjct: 1990 HNST-----LKQLMREFNTQLAQKEQELEMTIKETINKAQEVE------AELLESHQEET 2038
Query: 2494 NNYI-VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ-EQLVSKLSQVEGEHQLW 2551
N + + + L + + ++ L+ ++EE++ +Q Q E+L K Q + +
Sbjct: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098
Query: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
N+ + L +L QK ++ Q+ E + NLE+ L+
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH----NLEDRLK 2141
Score = 207 bits (528), Expect = 1e-52
Identities = 367/1716 (21%), Positives = 698/1716 (40%), Gaps = 243/1716 (14%)
Query: 23 LEGQLDKLKKE-----KQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK-RENQRLMEIC 76
L+ +L ++K+E K+ + Q+ L+ +K+ + E E T+ + RE Q M++
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV- 513
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI-EKLEQELKRCKSELE----RSQQA 131
+LEK++ + Q KE Q + +L KK I + E +L+ + E E R +
Sbjct: 514 -ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 132 AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
S + SL K L + + + EK+ E+E K + AL +
Sbjct: 573 ESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQ---DALWTE 629
Query: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQEKT---PSHLSSNSQRTPIRRDFSA----S 244
K Q L Q + R + + ++K +H+ +++T + D S
Sbjct: 630 KL-QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 245 YFSGEQEVTPSRSTLQ--IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ 302
S EV +R L+ + + + +Q Q++ + I E E+ +Q
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ 748
Query: 303 GHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ 362
EK +K Q+N +L+L L++ L E + + ++ R+ + QAS K +
Sbjct: 749 RTEKALKDQIN---QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ- 804
Query: 363 KLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT 422
S + E+ K ++E+L++ Q+ L+ E I + ++
Sbjct: 805 ---------------------SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVA 843
Query: 423 QELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF------------QAS 470
+ Q K++ L A ++ + QQLE E +QK+ Q + Q
Sbjct: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 471 QI---KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL--------KNIKQCLNQS 519
QI KEN + + E KKE +L K + L E K +++ ++
Sbjct: 904 QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
Query: 520 QNFAEEMKAKNTSQETMLRDLQE----KINQQENSLTLEKLKLAVADLEKQRDCSQDLLK 575
+ E +K K QE L+ E +++Q+E + L++A A+ D L
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
Query: 576 KREHHIE--------QLNDKLSKTEK------ESKALLSALELKKKEYE--ELKEEKTLF 619
++ IE +LND +S EK E + ++L++KE E ELK++ LF
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
C K E K +T ++ E + +N L+ LK + + V +L D L +
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK-------QKSAHVNSLAQDETKLKAHL 1136
Query: 680 RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
L L+ E + +EL+ AE D++ K S+LT +++ + +
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAE-EDKR----------KVSELTSKLKTTDEEF 1185
Query: 740 QLLSNEIMDKDRCYQDLHAEYESL-RDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFA 798
Q L + ++ +D E++ L +L D E +LL A +
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE----ALL-----EAKTNELI 1236
Query: 799 NIIGEQ-GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSL----ESQKQMNSDLQKQC 853
NI + ++ S S C+ + + I V LE L E Q +N Q+
Sbjct: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQAT 1296
Query: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
+L + + +I+ MKA+ +S V E LQ++ Q +E S + +KEL
Sbjct: 1297 HQLEEKENQIKS--MKAD--IESLVTEK----EALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 914 QLLNDKVETEQAEIQELKKSNHLLEDSLKELQL-LSETLSLEKKEMSSIISLNKREIEEL 972
+ V + E++E K L L +L + L ++SL +KE ++I SL K+ EE
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKE-AAISSLRKQYDEEK 1407
Query: 973 TQENGTLKEIN---ASLNQEKMNLIQKSESFANYIDEREKSISELSDQY----KQEKLIL 1025
+ +++++ +L++EK++ +++ + ++N E +K Q+ K+ ++ L
Sbjct: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQL 1467
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+ +E E ++ + ++N + +CL E E+ K+++E+ + E +
Sbjct: 1468 ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE----MEDDKSKMEKKESNLETELKSQ 1523
Query: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145
++ E+ +E+E++ + L++ K L Q L EE++ KE
Sbjct: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL-QHFQELGEEKDNRVKE 1582
Query: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
+ + E + MK + E + E E + SVK +E E + + + K L
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642
Query: 1206 YNAQLV-----QLEAMLRNKE---------------LKLQESEKEKECLQHELQTIRGDL 1245
Q + QL + + KE KLQE E+E L+ +L+++
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 1246 ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEK 1305
+ + ++ ++ + E + + +E S L E EK
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS------------VLQRNLTEKEK 1750
Query: 1306 ICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIP 1365
+ + + EK E V+ + R + E + KL + ++D ++ G L E++
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQ-------YQERLIKLEHAEAKQHEDQSMI-GHLQEEL- 1801
Query: 1366 GGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE----LQEKFLSLQ-SEHKI 1420
E+ N+++ + +A E ++ + + ++ F + LQEK L+ Q E KI
Sbjct: 1802 -----EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 1421 LHDQHCQMSSK------MSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVP 1474
C + K M EL + + L+A + + RN +L++E
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQA---LQQMDGRNKPTELLEEN---------- 1903
Query: 1475 SLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE 1534
+ S S L + Q D+ L GA Q E+ LQ++
Sbjct: 1904 -------TEEKSKSHLVQPKLLSNMEAQHNDLEF--KLAGAEREKQKLGKEIV--RLQKD 1952
Query: 1535 -NLTRKETPSAPAKGVEELESLCEVYRQSL-EKLEEKMESQGIMKNKEIQEL----EQLL 1588
+ RKE +ELE L + Y Q EK++++ E + N +++L L
Sbjct: 1953 LRMLRKEHQ-------QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQL 2005
Query: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKL 1624
+ + QEL+ K+ +++ ++ + +L E ++L
Sbjct: 2006 AQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041
Score = 202 bits (515), Expect = 3e-51
Identities = 414/2126 (19%), Positives = 862/2126 (40%), Gaps = 349/2126 (16%)
Query: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE 68
+E L R + IQ + Q L EK+ Q QLD L+K K EKT+ R+
Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350
Query: 69 NQRLMEICES-----LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
+ L+E E + +TK+++ L++KE ++ QL S KQ+ +EL+ K
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI----AQLRSRIKQMTTQGEELREQKE 406
Query: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
+ ER+ A + + +L+ + K E+ + K E++E+ +
Sbjct: 407 KSERA--AFEELEKALS-------------------TAQKTEEARRKLKAEMDEQIKTIE 445
Query: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243
+ + Q L + D+ + SS Q +++
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKK------------------SSEEQIAKLQKLHEK 487
Query: 244 SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL-LDQLKAQNQELRNKINELELRLQ 302
EQE+T T + ++ + S S +L + Q K Q + L + ELEL+ +
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL--ALEELELQKK 545
Query: 303 GHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL--------NKCRDELVRTTAQYDQAS 354
E + NK ++LQ + E + ++E E L N+ +D V A+ ++ +
Sbjct: 546 AILTESE---NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
Query: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
+ T + +K K E L Q+ + + + ++ + E E E Q++ D+E
Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662
Query: 415 I------QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
I +M + ++L + L +EL ++ + +LE L K + + +Q +
Sbjct: 663 IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
Query: 469 ASQIKE-NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
A ++ N ++ ++ + KE+ + +E K +K +NQ + +E
Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTE-------------KALKDQINQLELLLKERD 769
Query: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
+ + +L+ I + E L KL V + + + + K E + QL K
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDV--FQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL 647
L + E++ +L ++ + E ++ K+ T K + + L+ Q+E + ++ K+ L
Sbjct: 828 L--LDLETERILLTKQVAEVEAQK-KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 648 ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKA 707
+++ ++ E+ + + +++EN+ +++R K +E+ TQKL+ E
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMRE----GQKKEIEILTQKLSAKE--DSI 938
Query: 708 EFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLL 767
+++++ + +N K ++ + ++++ + L +++D++ L E E+
Sbjct: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQ---ETLKKKLLDQE---AKLKKELEN----- 987
Query: 768 KSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
A ++ ++ Q + + A ++ + + E+ E E + N I
Sbjct: 988 ---TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFV------AET 881
+ + E Q+ LQ++ +E+ ++K +I + E+M++ +
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ 1104
Query: 882 SQRISKLQE---DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE 938
+++LQE SAH N +A+ E +L+ +K+E ++ + K N L+
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQ-------DETKLKAHLEKLE---VDLNKSLKENTFLQ 1154
Query: 939 DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSE 998
+ L EL++L+E +KR++ ELT + L E
Sbjct: 1155 EQLVELKMLAEE--------------DKRKVSELTSK-----------------LKTTDE 1183
Query: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLN 1058
F + EKS L D+ + K K ++E +L+
Sbjct: 1184 EFQSLKSSHEKSNKSLEDKSLEFK---------------------KLSEELAIQLDICCK 1222
Query: 1059 ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER----NQNLMLELETVQ--QALRS 1112
+ +L E + NEL + + + L++++ + R + L+++ TV +A
Sbjct: 1223 KTEALLEAKTNELINIS---SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQNK---MQKEVNDLLQENEQLMKVMKTKHECQNL 1169
++T+ QN +Q L+E++N+ M+ ++ L+ E E L K + + +
Sbjct: 1280 QLTEEQNTLNI---SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS- 1335
Query: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229
E E +K+ SE + +L+ K++ + S + QL L L+N + L E E
Sbjct: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN-SISLSEKEA 1394
Query: 1230 EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHL 1289
L+ + + +L +QD+ S ++ L +I A E+ ++ S +
Sbjct: 1395 AISSLRKQYDEEKCEL-LDQVQDL-SFKVDTLSKEKISALEQVDDWSNKFSEWKK---KA 1449
Query: 1290 QCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKIL 1349
Q N + EL+ E+ E YE ++N + E ++ G++ ++ +
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 1350 NDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE--SNSYEHLTLSDKEV---QMHF 1404
L EL E Q + + L+E N + + KE+ HF
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569
Query: 1405 AELQEKFLS--LQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK 1462
EL E+ + ++E KIL ++ Q+ S +EL+T L+ NL + + K
Sbjct: 1570 QELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKS----------K 1618
Query: 1463 EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQ---------TGDMSLLSNLE 1513
E +L E + S S++ + + + ++ + LL Q G S LS L
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
Query: 1514 GAVSANQCSVDEVFCSSLQEENLTRKETPSAP--AKGV------EELES---LCEVYRQS 1562
+ + V + L+ ++ ET P AK V EE +S + + Y +
Sbjct: 1679 TKLQEREREV-HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY------LSENEQWQQKLTSV 1616
+ L+ + + + + QE E+ +SS + +R QY L E Q + S+
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFE----MRCQYQERLIKLEHAEAKQHEDQSM 1793
Query: 1617 TLEMESKLAAEKKQTEQL---SLELEVARLQLQGLDLSSRSLLGI--DTEDAIQGRNESC 1671
++ +L + K+ + +E E + +Q + ++L + D + +Q + +C
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ----AKQNLENVFDDVQKTLQEKELTC 1849
Query: 1672 DISKEHTSETTE-RTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
I ++ E + +VH++ ++L EK+ + + G P
Sbjct: 1850 QILEQKIKELDSCLVRQKEVHRV----EMEELTSKYEKL------QALQQMDGRNKPTEL 1899
Query: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN-LQLRVKETSNENLRLLHV 1789
E E+K++ + LV L N E HN L+ ++ E +L
Sbjct: 1900 LEENTEEKSK--------------SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL--- 1942
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF 1849
+++ L +++ L K H QE++++ K E E E+ ++K+E DL K
Sbjct: 1943 ----GKEIVRLQKDLRML-RKEHQQELEILKK-EYDQEREE---KIKQEQEDLELK---- 1989
Query: 1850 SCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRS 1909
H L+++ + + N ++ ++E + +
Sbjct: 1990 ---HNSTLKQL-------------------------MREFNTQLAQKEQELEMTIKETIN 2021
Query: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENK------QKVIVCLEEELSVVTSERNQL 1963
+ +E E L + E Q K EKD++ K ++++ EEE++ +
Sbjct: 2022 KAQEVEAELLESHQE-ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ-- 2078
Query: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV 2023
T L++L +K ++K ++ E+ ++ + +++ + ++ +KT L+
Sbjct: 2079 -----------TQLEELQKKYQQKLEQEENPGNDNVTIMEL-QTQLAQKTTLISDSKLKE 2126
Query: 2024 SELLKDKTHLQEKLQSLEKDSQALSL 2049
E + +L+++L+ EK+ A ++
Sbjct: 2127 QEFREQIHNLEDRLKKYEKNVYATTV 2152
Score = 187 bits (475), Expect = 1e-46
Identities = 342/1589 (21%), Positives = 698/1589 (43%), Gaps = 228/1589 (14%)
Query: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQT-----GD-----MSLLS 1510
+ E Q L++ L P+ +SS + + S SSF L E T GD L
Sbjct: 9 ISEEQQQLQQALAPAQASSNSSTPTRMRSR-TSSFTEQLDEGTPNRESGDTQSFAQKLQL 67
Query: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
+ S + + E S +E+L R T S + +L+S + + E
Sbjct: 68 RVPSVESLFRSPIKESLFRSSSKESLVR--TSSRESLNRLDLDSSTASFDPPSDMDSEAE 125
Query: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQ 1630
+ G + ++L Q L + L R +Y SE Q L +++ L+ + +
Sbjct: 126 DLVGNSDSLNKEQLIQRLRRMERSLSSYRGKY-SELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 1631 TEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDV 1690
+ + EL R +LQ +D ++ L + + +++ +++ + + S +R
Sbjct: 185 SLRRIAEL---REELQ-MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRL----- 235
Query: 1691 HQICDKDAQQDLNLDIEKITETGAVKPTGEC-SGEQSPDTNYEPPGEDKTQGSS-ECISE 1748
+N+D+ K ++P E + E++P+++ EP ED T + E + +
Sbjct: 236 -------RNGPMNVDVLK--PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
Query: 1749 LSFSGPNALV-----------PMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKV 1797
N L L ++++ QL + E ++ LH+ E K+
Sbjct: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKT--KL 344
Query: 1798 ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1857
+ L + K L +L + ++ + + ++ + + ++E + L +++ + +EL
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKR--QMHETLEMKEEEIAQLRSRIKQMTTQGEELR 402
Query: 1858 QRVETSE-GLNSDLEM---------HADKSSREDIGDNVAKVNDSWKERFLDVENELSRI 1907
++ E SE +LE A + + ++ + + + + +E + ++ ELSR+
Sbjct: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV 462
Query: 1908 RSE-----KASIEHEALYLEA--DLEVVQTEKLCLEK----DNENKQKVIVCLE----EE 1952
+ E K S E + L+ + E+ + E+ +K + E ++++ V LE E
Sbjct: 463 KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEY 522
Query: 1953 LSVVTSERNQLRGELDTMS-KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE 2011
L + + Q L+ + +K L + K+++ QE E++++ L E ++E
Sbjct: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
Query: 2012 KT----ELLQTLSSDVSELLKDKTHLQEK----LQSLEKDSQALSLTKC---------EL 2054
+L L ++ ++ K+ T + EK L+SL+ AL K E+
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 2055 ENQIAQLNKEKELLVKESESL-QARLSESD---YEKLNVSKA-LEAALVEKGEFALRLSS 2109
E + +EKE L+K+ E + QA + E + EKL+V + LE+ E E
Sbjct: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 2110 TQEEVHQLRRGIEKLRVRIEA--DEKKQLH---IAEKLKERE----RENDSLKDKVENLE 2160
+EE+ L+ +K++ +EA DE+K H + +KE E R +LKD++ LE
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLE 762
Query: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
L+ +++ + EN +A+++ + ++++ + L VF+ + +S TK +
Sbjct: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ----SYQSATHEQTKAYE 818
Query: 2221 EKQGQLSELDKLLS-SFKSLLEEKEQAEIQIKEES--------KTAVEMLQNQLKELNEA 2271
E+ QL + KLL + +L K+ AE++ +++ K V+ L QL++ N
Sbjct: 819 EQLAQLQQ--KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
Query: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
+ ++ +K+ Q + +E+ ++ + +++ +K+ +LQ + +
Sbjct: 877 M------EQKVKSLTQVYESKLEDGNKEQEQTKQILV------EKENMILQMREGQKKEI 924
Query: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV-VTI 2390
++L ++ E + I N+E+ + +N + ++E +K K + M ++L+ LD +
Sbjct: 925 EILTQKLSAKEDSIHIL--NEEYET-KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
Query: 2391 RSEKENLTNELQKEQERISE--LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL- 2447
+ E EN EL +++++ + LE+ ++ I + + KE+ + E+ + +L
Sbjct: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
Query: 2448 -------KELNERVAALHNDQEA-CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
K+LN++ L E + KEQ E EL++ LL G ++ + N +
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQ------EVAELKQKILLFGCEKEEMNKEIT 1095
Query: 2500 QSSVNGLIQE--VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE-------GEHQL 2550
G+ Q+ + + +++L++K ++ L QD+ +L + L ++E E+
Sbjct: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVNSLA---QDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
+EQ +EL+ L E ++K+ L SK + + + L+SS++ LE ++ E+
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 2611 VN---KMTAKETE--LQREMHEM----AQKTAELQEELSGEKNRLAGELQLLLEE---IK 2658
+ + K+TE L+ + +E+ + KT + +S ++R + LL + +
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
Query: 2659 SSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
+ QL++LT E + L S EKE +++ A+ + + E E AL +
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGG 1328
Query: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL 2778
Q ++ + KE C++ K +EL+ ++ A T + EELK+ K++
Sbjct: 1329 NQ--------QQAASEKESCITQLK----------KELSENINAVTLMKEELKEKKVEIS 1370
Query: 2779 KYVNQLKKENERAQGKMKLLIKSC------KQLEEEK--------------EILQKE-LS 2817
QL N + Q + L K KQ +EEK + L KE +S
Sbjct: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKIS 1430
Query: 2818 QLQAAQEKQKTGTVMDTKVDELTTE----IKELKETLEEKTKEADEYLDKYCSLLISHEK 2873
L+ + + K T+ +KEL+ LE K+KEA E D+ +LL E+
Sbjct: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE-KDEQINLL--KEE 1487
Query: 2874 LEKAKEMLETQVAHLCSQQSKQDSRGSPL 2902
L++ + + + +SK + + S L
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Score = 179 bits (454), Expect = 4e-44
Identities = 298/1373 (21%), Positives = 578/1373 (42%), Gaps = 189/1373 (13%)
Query: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65
E+ K+ L + +Q EGQ +++ Q+ + DS+ ++ + K +N++ + +
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959
Query: 66 KRENQRLME-ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE---LKRC 121
K++ + + E + + L + K+ EL+ +++ +E Q N+ K +E + +
Sbjct: 960 KQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDA 1017
Query: 122 KSELERSQ--QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
S LE +Q Q +V N I+ L + E+L+E + +++E+
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKL-------NQQAEELQEIHEIQLQEK- 1069
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
E EV L+ K + MN +W +E+ ++ ++ +
Sbjct: 1070 --EQEVAELKQKILLFGCEKEEMNKE-----------ITWLKEEGVKQDTTLNELQEQLK 1116
Query: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
SA S Q+ T ++ L+ + D N S +N+ L +LK +E + K++EL
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
+L+ ++E FQ L+ EK+ L +K K +EL Q D K A
Sbjct: 1177 KLKTTDEE-------FQSLKSSHEKSNKSLEDKSLEFKKLSEEL---AIQLDICCKKTEA 1226
Query: 360 LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE-------FQEELSRQQRSFQTLDQ 412
L + ++S + NA +R S Q K KE EL Q R T +Q
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL-TEEQ 1285
Query: 413 ECIQMK-ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
+ + + T +L++ +N ++A+++ L + K+ L+ +Q E
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI---- 1341
Query: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
+L++ + E L+K ++K E+ L +L ++ L S + +E+ A ++
Sbjct: 1342 ---TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
Query: 532 SQETMLRDLQEKINQ-QENSLTLEKL-KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
++ + E ++Q Q+ S ++ L K ++ LE+ D S K ++ + +
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS----NKFSEWKKKAQSRFT 1454
Query: 590 KTEKESKALLSALELKKKE-----------YEELKEEKTLFSCWKSENEKLLTQMESEKE 638
+ + K L LELK KE EEL ++ F C K E ME +K
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE-------MEDDKS 1507
Query: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
++ K ++LET LK+Q + E + + ++ E+L+ ++N + D + E+ QKL
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL-VQKL 1566
Query: 699 AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
+ + E ++K + V++ E K+ L N++ +
Sbjct: 1567 QHFQ-----ELGEEKDNR---------------VKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
E E + +KSK+ L ED S A ++ +E + +A
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESA----------------------AKLAELKRKA 1644
Query: 819 DQSPKNSAILQNRVDSLEFSLESQK--------QMNSDLQKQCEELVQIKGEIEENLMKA 870
+Q K +AI + + +E E K ++N+ LQ++ E+ ++ +++ +++
Sbjct: 1645 EQ--KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS--VES 1700
Query: 871 EQMHQSFVAETSQRISKLQEDTSAH-----QNVVAETLSALENKEKELQLLNDKVETEQA 925
Q V +++ ++ E A Q E +S L+ E + L +V E+
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK- 1759
Query: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985
+E S+ + +E + E ++ E S+I + E+EE ++ + +
Sbjct: 1760 --EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817
Query: 986 LNQEKMNLIQKSESFANYIDEREKSI--SELSDQYKQEKLILLQRC-----EETGNAYED 1038
K N IQ ++ N D+ +K++ EL+ Q ++K+ L C E E+
Sbjct: 1818 KEGGKNN-IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 1039 LSQKYKAAQ-----EKNSKLECLLNECTSLCENRKNELEQ--LKEAFAKEHQEFLTKLAF 1091
L+ KY+ Q + +K LL E T E K+ L Q L +H + KLA
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTE--EKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL-L 1150
AE Q L E+ +Q+ LR ++Q E LK+E +E + K+++E DL L
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQ----QELEILKKEYD--QEREEKIKQEQEDLEL 1988
Query: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
+ N L ++M+ + + + + ++KE ++ EV+ L+S+ +
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ----------EVEAELLESHQEET 2038
Query: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
QL + K+ L+ + K E E+ R + T+ ++D+Q+Q + ++
Sbjct: 2039 NQLLKKIAEKDDDLKRTAKRYE----EILDAREEEMTAKVRDLQTQ--------LEELQK 2086
Query: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND 1323
KY + NDN + LQT + + L ++ + E E + L D
Sbjct: 2087 KYQQKLEQEENPGNDNVTIM-ELQTQLAQKTTLISDSKLKEQEFREQIHNLED 2138
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 265 bits (678), Expect = 4e-70
Identities = 544/2667 (20%), Positives = 1092/2667 (40%), Gaps = 394/2667 (14%)
Query: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
L+ +L+A+ + R+ ELE RL+ + + +E L ++ V L E+++
Sbjct: 55 LVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNL--DELLVRLEEEQQRCES 112
Query: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA--ESARCSLEQKI-KEKEKE 395
+ + ++A AL + ++KLT D S R + ++ +EQ+ K K
Sbjct: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
Query: 396 FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD----KLTSVKQQLEN 451
L R T + ++MK+ ++L + K H L L +LT Q E
Sbjct: 173 EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232
Query: 452 NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511
N A+ + K EL + E +E LKS + + E L+ +
Sbjct: 233 NGSGRMDGREPAQLLLLLA--KTQELEKEAHERSQELIQLKSQGDLEKAE---LQDRVTE 287
Query: 512 IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT--LEKLKLAVADLEKQRDC 569
+ L QSQ +N E M++ L+E + E + T +E + ++++
Sbjct: 288 LSALLTQSQK-------QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 570 SQDLLKKREHHIEQLNDKLSKTEKESKAL-LSALELKKKEYEELKEEKTLFSCWKSENEK 628
Q ++K + + D +++ +L L + + +Y++ + TL + +
Sbjct: 341 LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400
Query: 629 LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
+ + + Q +N L+ + + +R++ L +R+ L+ + +L +DS
Sbjct: 401 AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 689 KSVEVETQKLAYMELQQKAEFSDQKH---QKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745
S E E + A EL+Q+ E +Q+ ++ + L+ GQ E+ + +L L E
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 746 IMDKDRCYQDLHAEY-ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804
L A+ ESL +L+ ++A H L +Q + + A
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREA---LESSHLEGELLRQEQTEVTAALAR----- 572
Query: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
+E+S L + ++ + + R +++ S + E L K +
Sbjct: 573 ----AEQSIAELSSSENTLKTEVADLRAAAVKLSALN------------EALALDKVGLN 616
Query: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
+ L++ E+ +QS + R+ ++ +A Q +AE EK + L +K +
Sbjct: 617 QQLLQLEEENQSVCS----RMEAAEQARNALQVDLAEA-------EKRREALWEKNTHLE 665
Query: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
A++Q+ +++ L+ L+++Q E + + E ++E+L QE +E+ A
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
Query: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044
QEK L+++ + + E+ +L++Q + +A E L
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQL-----------QGLSSAKELLESSLF 774
Query: 1045 AAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ----EFLTKLAFAEERNQNLM 1100
AQ++NS +E + E + + Q KE E + E T+ + AE+
Sbjct: 775 EAQQQNSVIEVTKGQL----EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAA 830
Query: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVM 1160
+L +Q ++ + + + E L+++ ++E++ Q+E+ L+ E+ +
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQLREK---WEKERSWHQQELAKALESLEREKMEL 887
Query: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
+ + + Q E E I+ +E ++ + Q++ E + +SL LE +L
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL---------LETLL--- 935
Query: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280
+++KE +L+ +R D++ L++ ++ I + E E K + H
Sbjct: 936 -----QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH--- 987
Query: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT---ATRKMAE 1337
++D A LQ E+ +LQ +K +L ++ D +S+ + + R + +
Sbjct: 988 --RDDLAALQ-------------EESSSLLQ-DKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
Query: 1338 EVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD 1397
EV + L E + N + EL + EQ L L E++S LS
Sbjct: 1032 EVQEKLRETQEYNR----IQKELEREKASLTLSLMEKEQR---LLVLQEADSIRQQELSA 1084
Query: 1398 KEVQMHFAELQEKFLSLQSE--HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455
M A+ ++K LS Q E + + ++ ++ ++L ++ L+A ++ +
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITEQQLRAS 1141
Query: 1456 FQGDLVKEMQLGLE----EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDM----- 1506
K QL L E + +L++ P + + + +S Y AL + G +
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
Query: 1507 SLLSNLEGAVSANQCSVDEVFCSSLQEEN-----LTRKETPSAPAKGVEEL---ESLCEV 1558
L + A S D+ SL + L+ + SA K ++L + +V
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 1559 YRQSLEKLEEKM---ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTS 1615
R ++KLEE++ E++ + E+Q+L++ LS ++E S+ E Q L S
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK--------SKWEGKQNSLES 1313
Query: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISK 1675
+E+ +A SL+ + R +LQ ++ QG E +K
Sbjct: 1314 ELMELHETMA---------SLQSRLRRAELQRMEA--------------QGERELLQAAK 1350
Query: 1676 EHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVK-PTGECSGEQSPDTNYEPP 1734
E+ + E V A L D+ T A+K E E+ +
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLR--TARSALKLKNEEVESERERAQALQEQ 1408
Query: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD 1794
GE K L AL+ +E++ L+ +++E ++
Sbjct: 1409 GELKVAQGKALQENL------ALLTQTLAEREEEVETLRGQIQEL------------EKQ 1450
Query: 1795 RKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQ 1854
R+++ E+ LD K QEV L E ELEK L+ + E+ + + +
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 1855 ELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
++ E+ D+ ++ ++ ++ + L++E + I S++ +
Sbjct: 1509 QIR-------------ELEKDRETQRNVLEH----------QLLELEKKDQMIESQRGQV 1545
Query: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974
+ + ++V E L LE + EN K+ C ++ + +L G+ +T +
Sbjct: 1546 Q------DLKKQLVTLECLALELE-ENHHKM-ECQQKLIK-------ELEGQRET---QR 1587
Query: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQ----VAEAEVKEKTELLQTLSSDVSELLKDK 2030
AL L+ ++E++QEL++ S+ +H ++ V E++E+ + +++ + EL + K
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQ-IHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646
Query: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
HL Q LE+ Q L L K ++ Q ++ ++L ++ E ++ L E E L
Sbjct: 1647 EHLT---QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE-LTTQ 1702
Query: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
+ L E+G+ + R +E +++ + EK+ E + E + D
Sbjct: 1703 RQLMQERAEEGKGPSKAQ---------RGSLEHMKLILRDKEKEVECQQEHIHELQELKD 1753
Query: 2151 SLKDKVENLERE-----LQMSEENQELVILDA------ENSKAEVETLKTQIEEMARSLK 2199
L+ +++ L R+ L +S+ QE+V+L E + + ++L++Q++E R+L
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813
Query: 2200 VFELDLVTLRSEKENLTKQ---IQEK----QGQLSELDKLLSSFKSLLEE-KEQA----- 2246
+ +L L+ E++ Q ++EK QG L + L L++ KEQA
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873
Query: 2247 EIQIKEESKTAVEMLQNQLK-ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
E+ ++ A+E + L+ E E AL Q+ + EQ+ + +E L++S +
Sbjct: 1874 ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ--QCAEQAQEHEVETR-ALQDSWLQ 1930
Query: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART----NQEHAALEAEN 2361
+A L+ +++ + + + S H + + R E L+ L A ++H +AE
Sbjct: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
Query: 2362 SKG---EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
S+ TL+A ++ R LE +R ++ + ++ + QE + +L+ +
Sbjct: 1991 SRSLEASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047
Query: 2419 ENIL---QEKEQ-------EKVQ---MKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
+ L QE+EQ ++VQ ++EK + E + +++ L++ V L Q
Sbjct: 2048 DEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL---QLTLA 2104
Query: 2466 AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS 2525
KEQ E LEL + Q L+ +++ +E+ KL+ + +
Sbjct: 2105 QKEQ------EILELRETQQRNNLEALPHSHKT---------SPMEEQSLKLDSLEPRLQ 2149
Query: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
R + E+L + L Q E W+E+ +L + + + LQ LQ ++
Sbjct: 2150 R------ELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE 2203
Query: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
S + L++ELELT+ + E +R A TAEL
Sbjct: 2204 RDSEQQRLQDELELTR---------------RALEKERLHSPGATSTAELGSR------- 2241
Query: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHE 2705
GE + L E+ + + +E ++ L+ + ++ R EI +L
Sbjct: 2242 --GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHL------QQAVARLEIDRSRL---- 2289
Query: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
++H L T +Q E E R KL +E ++Q +++ K++ A++
Sbjct: 2290 --QRHNVQLRSTLEQVERE----RRKL-KREAMRAAQAGSLEISKAT---------ASSP 2333
Query: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
++ + K + K V +L+KE Q ++ L K + +EL+ L +
Sbjct: 2334 TQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSH 2393
Query: 2826 QKTGTVMDTKVDELTTEIKELKETLEE 2852
+ L E + L E+L +
Sbjct: 2394 SLLAVAQAPEATVLEAETRRLDESLTQ 2420
Score = 220 bits (560), Expect = 2e-56
Identities = 459/2211 (20%), Positives = 874/2211 (39%), Gaps = 336/2211 (15%)
Query: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR------------IS 886
LE + + DL + E V++ G + ++ QS S R ++
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA 251
Query: 887 KLQE-DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ 945
K QE + AH+ E + + E L D+V A + + +K N E +K L+
Sbjct: 252 KTQELEKEAHERS-QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310
Query: 946 LLSETLSLEKKE-MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
E L E M SL++ EE +K+I + +E N+ Q S N +
Sbjct: 311 ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS-GHENSL 369
Query: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
E + SI D +K + L R L+++ +A Q+ +L + C
Sbjct: 370 -ELDSSIFSQFDYQDADKALTLVRSV--------LTRRRQAVQDLRQQL--------AGC 412
Query: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
+ N L+Q + + +E + +R Q L E +T L + D Q E
Sbjct: 413 QEAVNLLQQQHDQWEEEGKAL-------RQRLQKLTGERDT----LAGQTVDLQG----E 457
Query: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE 1184
L +E L++ + ++++++ L QE +L +V N+E + +S + ++ E
Sbjct: 458 VDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV--------NVELQLQGDSAQGQKEE 509
Query: 1185 RNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGD 1244
+ + ++ L V+E +L+ ML E K ES E L T+R
Sbjct: 510 QQE-----ELHLAVRERE---------RLQEMLMGLEAKQSESLSE-------LITLREA 548
Query: 1245 LETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL 1303
LE+S+L+ ++ QE + + AE+ ELS+S+N L+ KL+ L
Sbjct: 549 LESSHLEGELLRQEQTEVTAALARAEQSIA----ELSSSENTLKTEVADLRAAAVKLSAL 604
Query: 1304 EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
E L +K L +L ++ EE + + ++ L +L E
Sbjct: 605 N---EALALDKVGLNQQL-----------LQLEEENQSVCSRMEAAEQARNALQVDLAEA 650
Query: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD-----KEVQMHFAELQEKFLSLQSEH 1418
E + N L +E+ + L D +E+Q +E + + + ++
Sbjct: 651 EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQL 710
Query: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD---LVKEMQLGL---EEGL 1472
+ LH + + ++ ++L E L L+ + D L +++Q GL +E L
Sbjct: 711 EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-GLSSAKELL 769
Query: 1473 VPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQ 1532
SL + +S + G + Q ++ ++G V + +D + Q
Sbjct: 770 ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQ 824
Query: 1533 EENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEI----------- 1581
E + ++ A +G LE + + + +L EK E + +E+
Sbjct: 825 ERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREK 884
Query: 1582 QELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESK-------LAAEKKQTEQL 1634
ELE L ++ E++ ++ Q E Q + L + LE E + L +K+
Sbjct: 885 MELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA 944
Query: 1635 SLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE--------TTERTP 1686
S +LE R ++ L + GI + + E + +++H + ++
Sbjct: 945 SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 1687 KHDVH-QICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSEC 1745
K D+ Q+ D +Q D +++ E + E E T E
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 1746 ISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
L L D + Q+++ L+ ++E E L ++E L E+K
Sbjct: 1065 EQRLL-----VLQEADSI-RQQELSALRQDMQEAQGEQKEL-------SAQMELLRQEVK 1111
Query: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEG 1865
E ++ QE QL+ ++EA E+ L L +L R+ ++E
Sbjct: 1112 EKEADFLAQEAQLLEELEASHITEQ----------QLRASLWAQEAKAAQLQLRLRSTE- 1160
Query: 1866 LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEH--EALYLEA 1923
S LE A E N A+ + ++ L + + + ++
Sbjct: 1161 --SQLEALA----AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214
Query: 1924 DLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEK 1983
LE Q L K + ++ L E V S ++L +L + L +K
Sbjct: 1215 GLEPDQNGARSLFK----RGPLLTALSAE--AVASALHKLHQDLWKTQQTRDVLRDQVQK 1268
Query: 1984 MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
++E+ + E+ +S+ +Q + ++ + E + L + L E + SL+
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 2044 SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK--- 2100
+ L + E + + L KE L + E LQA + E+ ++A A ++E+
Sbjct: 1329 LRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEAR------AQASAAGILEEDLR 1382
Query: 2101 -GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH-----IAEKLKERERENDSLKD 2154
AL+L + + E + R + + ++ + K L + + L ERE E ++L+
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 2155 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
+++ LE++ +M + EL+ LD + EV+ + QI+E+ + V E + ++ ++
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK 1502
Query: 2215 LTKQ-------------------------------IQEKQGQLSELDKLLSSFKSLLEEK 2243
LT Q I+ ++GQ+ +L K L + + L E
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 2244 EQAEIQI-------------KEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
E+ ++ +E + A+ L L+E ++ + A +++ L
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE----RELE 2346
++E Q ++ R ++E ++++ + Q L+ + L K R++ LE R+ +
Sbjct: 1623 RELQERDQ---EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679
Query: 2347 IARTNQEHAAL------------------EAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
I + E L AE KG + + +E M LR E +V
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739
Query: 2389 -------TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAME 2441
++ K+ L +LQ ++ E ++ S E + +Q+ + +E+ +
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799
Query: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
LQ+QL E +A + EA + ++Q Q E ++ EKA LQG E + + +
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK-EKADALQGALEQAHMTLKERH 1858
Query: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL 2561
E++D K++ + +EE++ ++Q E+++ L +EQ L L
Sbjct: 1859 G------ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES------REQEKALLAL 1906
Query: 2562 TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETEL 2621
+ ++ Q + + +LQD+ Q+ K + ELE + E++
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR---------------AESQS 1951
Query: 2622 QREMHEMAQKTAE-LQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
R E A+ AE LQE L L G+ Q LLE+ + S + L + L+ SLD
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS----RSLEASTATLQASLDA 2007
Query: 2681 --MHKDQVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK-- 2735
H Q+E+ +++E EI + LR E ++ Q L + E+ Q RE+L K
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL--AQRDEELRHQQEREQLLEKSL 2065
Query: 2736 ----EECLSSQKL---------EIDLLKSSKEELNNSLKATTQILEELKKTKM-DNLKYV 2781
+E + +K EI L S EL +L Q + EL++T+ +NL+ +
Sbjct: 2066 AQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEAL 2125
Query: 2782 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV-MDTKVDELT 2840
K + + +K L+ + LQ+EL +LQAA + + + K +L
Sbjct: 2126 PHSHKTSPMEEQSLK--------LDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 2841 TEIKELKETLEEKTKEA----DEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887
+ + K ++ + A L++ ++LE + LE + H
Sbjct: 2178 LSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228
Score = 210 bits (535), Expect = 2e-53
Identities = 479/2316 (20%), Positives = 910/2316 (39%), Gaps = 442/2316 (19%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEA---ALQKQKQKVENEKT----EGTNLK 66
TR Q +Q+L QL ++ Q Q D E AL+++ QK+ E+ + +L+
Sbjct: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE---LKRCKS 123
E L + E L+K ++++ ++Q+E LEQE L+R
Sbjct: 456 GEVDSLSKERELLQKAREEL---------------------RQQLEVLEQEAWRLRRVNV 494
Query: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
EL+ +AQ G K E+ +E+ + V ER+RL+
Sbjct: 495 ELQLQGDSAQ---------------------------GQK-EEQQEELHLAVRERERLQE 526
Query: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243
+ L+AK++ ++ S + + ++ SHL R + + +A
Sbjct: 527 MLMGLEAKQS-----------------ESLSELITLREALESSHLEGELLRQE-QTEVTA 568
Query: 244 SYFSGEQ---EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR 300
+ EQ E++ S +TL+ D ++ +L A N+ L L +
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAV----------KLSALNEALALDKVGLNQQ 618
Query: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
L E+E + ++ + + +V+L E EK ++ AQ +A L
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 361 EQKLKKLTED-------LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
+ L+ + E+ LS R E+A LEQ + ++ K +E L+R + + L +E
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ-LHQEAKRQEEVLARAVQEKEALVRE 737
Query: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
KA L LQ + L +L L+S K+ LE++L E +Q+ E +++
Sbjct: 738 ----KAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 474 ENELRRSMEEMKKENNLLKSHSE-QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
+ ++ E ++ E LK + ++++ +A + + Q + + E+ KA +
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
Query: 533 QETMLRDLQEK---INQQENSLTLEKLKLAVADLE----KQRDCSQDLLKKREHHIEQLN 585
+ LR+ EK +QQE + LE L+ +LE +Q+ + + +RE Q
Sbjct: 854 EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913
Query: 586 DKLS----KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQ 641
L +TEKE +LL L +KE + ++ E+L M+ +K Q
Sbjct: 914 SALCQMQLETEKERVSLLETLLQTQKELADASQQL----------ERLRQDMKVQKLKEQ 963
Query: 642 SKINHLETCLKTQQIKSHE-----------YNERVRTLEMDRENLSVEIRNLHNVL---- 686
L+T L+ Q + E E +L D+ +L ++ +L + L
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
Query: 687 -DSKSVEVETQK-----------------------LAYMELQQK---AEFSDQKHQKEIE 719
+ VE E Q+ L+ ME +Q+ + +D Q+E+
Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083
Query: 720 NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED 779
+ + G+ ++L +++LL E+ +K+ + A+ LL+ +AS +T +
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ------LLEELEASHITEQQ 1137
Query: 780 HQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLE---ADQSPKNSAILQNRVDSLE 836
+ SL A + + A Q + +E +LE A+Q P N A Q ++ SL
Sbjct: 1138 LRASLWAQEAKAA-----------QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLY 1186
Query: 837 FSLESQKQMNSDLQKQCEELVQIKG-----------EIEEN----LMKAEQMHQSFVAE- 880
+L+ L CE ++ G E ++N L K + + AE
Sbjct: 1187 SALQQA------LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240
Query: 881 TSQRISKLQED---TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL 937
+ + KL +D T ++V+ + + LE + + + +V TE ++Q N
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE 1300
Query: 938 EDSL--KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
+ K+ L SE + L + S L + E++ + + E+ L
Sbjct: 1301 KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG------------ERELLQA 1348
Query: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
E+ ++ + ++ E Q G EDL A + KN ++E
Sbjct: 1349 AKENLTAQVEHLQAAVVEARAQ-----------ASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
+L E +LK A K QE L L + E E + LR ++
Sbjct: 1398 ERERAQAL-----QEQGELKVAQGKALQENLALLT-------QTLAEREEEVETLRGQIQ 1445
Query: 1116 DNQNNSKSEAGGLKQEIMTLK---EEQNKMQKEVNDLLQEN---EQLMKVMKTKHECQNL 1169
+ + + + L+ + LK +E + Q+++ +L + E L ++ + + +
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505
Query: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE---LKLQE 1226
+ E IR K+RE++RN + ++LE K+ ++S Q+ L+ L E L+L+E
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQ-LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
Query: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
+ + EC Q ++ + G ET + L +D EE+ + S +
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRV---------ALTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 1287 AH---LQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL 1343
+H L LQ ++ + E LQ +K L +L E + ++ +
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQ---PNEQHPVSLAPLD-ESNSYEHLTL---- 1395
+ KIL +D + L E G E Q E+ P + S EH+ L
Sbjct: 1676 RQTKILEEDLEQIKLSLRE--RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 1396 SDKEV---QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN 1452
+KEV Q H ELQE L+ + + LH K+ E + + E +VL
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQLQGLH-------RKVGETSLLLSQREQEIVVLQQQ 1786
Query: 1453 LRNF--QGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
L+ QG+L ++ SL S D + RAL ++ ++ L
Sbjct: 1787 LQEAREQGELKEQ----------------------SLQSQLDEA-QRALAQRDQELEALQ 1823
Query: 1511 NLEGAVSANQCSVDE---VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE 1567
+ + V E +L++ ++T KE EL+ +++ +LE
Sbjct: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG-------ELQD----HKEQARRLE 1872
Query: 1568 EKMESQGIMKNKEIQELEQLLSSERQE-------LDCLRKQ---YLSENEQWQQKLTSVT 1617
E++ +G + +Q LE++L R E L L++Q E+E + L
Sbjct: 1873 EELAVEG----RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 1618 LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL---LGIDTEDAIQGRN----ES 1670
L+ ++ L ++ E L E + +R Q + + +L LG A+QG+ E
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG-KAHAALQGKEQHLLEQ 1987
Query: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
++S+ + T D Q + ++ L + +I Q D
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI---------------QDQDLR 2032
Query: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGN--QED-IHNLQLRVKETSNENLRLL 1787
Y+ + Q ++ EL + L QE+ I Q +E E +R L
Sbjct: 2033 YQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092
Query: 1788 HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847
H R+++ L + ++ L L+E Q +EA K + S KL+
Sbjct: 2093 H---QSVRELQLTLAQKEQ--EILELRETQQRNNLEALPHSHK-----TSPMEEQSLKLD 2142
Query: 1848 YFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRI 1907
Q L+R++ + E+ W+E+ D+ L++
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAREI-------------------EWREKAQDLALSLAQT 2183
Query: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
++ +S++ A++L+A + LE+D SE+ +L+ EL
Sbjct: 2184 KASVSSLQEVAMFLQASV---------LERD-------------------SEQQRLQDEL 2215
Query: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
+ ++++ ++L T EL S + + +V+ E + + ++ S
Sbjct: 2216 E-LTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQS-----WR 2269
Query: 2028 KDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
+ HLQ+ + LE D L +L + + Q+ +E+ L +E+ + + L
Sbjct: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA------MRAAQAGSL 2323
Query: 2088 NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147
+SKA ++ ++ + +S + V +L++ + L+ ++ + K++ + + R
Sbjct: 2324 EISKATASSPTQQDGRGQK-NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSR 2382
Query: 2148 ENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183
E L +L L + E +L+AE + +
Sbjct: 2383 ELAGLH---HSLSHSLLAVAQAPEATVLEAETRRLD 2415
Score = 204 bits (518), Expect = 1e-51
Identities = 385/1768 (21%), Positives = 723/1768 (40%), Gaps = 231/1768 (13%)
Query: 8 WKEGLPTRA-LQKIQE----LEGQLDKLKKEKQQRQ--------------FQLDSLEAAL 48
W++ A LQK +E L+ L +++EK++ Q QL+ L
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 49 QKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK 108
++Q++ + E L RE L +++E+ +Q ++ +LQ S E L +
Sbjct: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Query: 109 KQIEKLEQELKRCKSELE-RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL 167
+Q +E K +LE + Q Q+ +V + T + ++ + L
Sbjct: 778 QQNSVIEV----TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833
Query: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227
+ E E + LE + KA K+ +Q L + R + + + ++ S ++EK
Sbjct: 834 AQ---AEQEGKTALEQQ-KAAHEKEVNQ-LREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 228 LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287
+ Q+T + A E+E T + S L LL+ L
Sbjct: 889 MRLKEQQT----EMEAIQAQREEERTQAESAL------CQMQLETEKERVSLLETLLQTQ 938
Query: 288 QELRNKINELELRLQGHEKEMKGQVNKFQE----LQLQLEKAKVELIEKEKVLNKCRDEL 343
+EL + +LE RL+ ++MK Q K QE LQ QL++A+ EL E + + RD+L
Sbjct: 939 KELADASQQLE-RLR---QDMKVQKLKEQETTGILQTQLQEAQRELKEAAR---QHRDDL 991
Query: 344 VRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE----- 398
A + S+ + L+K EDL Q + ++ +EQ+++EK +E QE
Sbjct: 992 ----AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 399 -ELSRQQRS--------------FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
EL R++ S Q D Q + L Q++Q+A+ L A+++ L
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELL- 1106
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM--EEMK----------KENNLL 491
+Q+++ +F + + + +AS I E +LR S+ +E K E+ L
Sbjct: 1107 --RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Query: 492 KSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL 551
+EQ+ +A+L ++ L Q+ E + + + + Q +
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
Query: 552 TLEKLKLAVADLEKQRDCS------QDLLKKRE------HHIEQLNDKLSKTEKESKALL 599
+L K + L + S QDL K ++ +++L ++L+ TE E +
Sbjct: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
Query: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
+ L+ +++ + +EEK S W+ + L ESE L + L++ L+ +++
Sbjct: 1285 TELQDLQRQLSQNQEEK---SKWEGKQNSL----ESELMELHETMASLQSRLRRAELQRM 1337
Query: 660 EYNERVRTLEMDRENLSVEIRNL------------------------HNVLDSKSVEVET 695
E L+ +ENL+ ++ +L + L K+ EVE+
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
++ LQ++ E + + EN+ L T L + E++E L +I + ++ +
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE----TLRGQIQELEKQREM 1453
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815
A E L LK ++ + ++ + L + + H + + + +R + R
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKC--RSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 816 -LEADQSPKNSAILQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
LE D+ + + +L++++ LE +ESQ+ DL+KQ L + E+EEN K E
Sbjct: 1512 ELEKDRETQRN-VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
Query: 872 QMHQSFVAE-----TSQRISKLQ-----EDTSAHQNVVAETLSALENKE----KELQLLN 917
Q + E +QR++ E+ S + + LE+ +ELQ +
Sbjct: 1571 -CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD 1629
Query: 918 DKVETEQAEIQEL-KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
+V++++ +I+EL ++ HL +D L+ + L L+K+ + + R+ + L ++
Sbjct: 1630 QEVKSQREQIEELQRQKEHLTQD----LERRDQELMLQKERIQVLEDQRTRQTKILEED- 1684
Query: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
L++I SL + L + + +E + + KLIL + +E
Sbjct: 1685 --LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742
Query: 1037 EDLSQKYKAAQEKNSKLECL---LNECTSLCENRKNEL----EQLKEAFAK---EHQEFL 1086
E + + + + +L+ L + E + L R+ E+ +QL+EA + + Q
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 1087 TKLAFAEERNQNLMLELETVQQ-ALRSEMTDNQNNSKSEA--GGLKQEIMTLKEEQNKMQ 1143
++L A+ ELE +QQ +++ + + K++A G L+Q MTLKE ++Q
Sbjct: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ 1862
Query: 1144 KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
+ E+L Q LE + RE E+ + Q + +E +
Sbjct: 1863 DHKEQARRLEEEL---AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263
++ Q L+A + L+E ++E E L+ E Q+ R E + + QE G
Sbjct: 1920 ETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
Query: 1264 CEIDAEEKYISGPHELSTS-QNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
+ +E+++ ELS S + A LQ SL +LE+ I + E+
Sbjct: 1975 AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG-------EIQ 2027
Query: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
D +++ + + + E++ + LL L + + E+ N L
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN------LG 2081
Query: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSL---QSEHKILHDQHCQMSSKMSELQTYV 1439
E L S +E+Q+ A+ +++ L L Q + + H +S M E +
Sbjct: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141
Query: 1440 DSLKAENLVLSTNLRNFQGDLVKEMQLGLE-EGLVPSLSSSCVPDSSSLSSLGDSSFY-- 1496
DSL+ L L Q L + +E L+ S +S+SSL + + +
Sbjct: 2142 DSLEPR---LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ 2198
Query: 1497 RALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLC 1556
++LE+ + L DE+ L L ++ S A EL S
Sbjct: 2199 ASVLERDSEQQRLQ-------------DEL---ELTRRALEKERLHSPGATSTAELGSRG 2242
Query: 1557 E--VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSS-ERQELDCLRKQYLSENEQWQQKL 1613
E V + +E + G+ K Q LE L + R E+D R + N Q + L
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID--RSRLQRHNVQLRSTL 2300
Query: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVA 1641
V E + + SLE+ A
Sbjct: 2301 EQVERERRKLKREAMRAAQAGSLEISKA 2328
Score = 189 bits (479), Expect = 5e-47
Identities = 504/2563 (19%), Positives = 978/2563 (38%), Gaps = 414/2563 (16%)
Query: 21 QELEGQLDKLKKEKQQR-----QFQLDSLEAALQKQKQKVENEKTEGTNLKRE------- 68
QELE +L+ QR + LD L L++++Q+ E+ T L+
Sbjct: 71 QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVV 130
Query: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQE-----------GQLNSGKKQIEKLEQE 117
N+ L E E L + EL KESQ ++ G+L S +++ +
Sbjct: 131 NKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRH 190
Query: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE-------- 169
KS +R ++ V L+ + T S+ +GS D +E
Sbjct: 191 FLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL 250
Query: 170 ----KYNKEVEERKR---------------LEAEVKALQA----------------KKAS 194
+ KE ER + L+ V L A K
Sbjct: 251 AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310
Query: 195 QTLPQATMNHRDIARHQASSS------VFSWQQ----------EKTPSHLSSNSQRTPIR 238
+T+ NH ++ H+AS S S QQ E+ + + +
Sbjct: 311 ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Query: 239 RDFSA----SYFSGEQEVTPSRSTLQIGKR---DANSSFFDNSSSPHLL----DQLKAQN 287
D S Y ++ +T RS L ++ D + +LL DQ + +
Sbjct: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG 430
Query: 288 QELRNKINELELR---LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELV 344
+ LR ++ +L L G +++G+V+ + + L+KA+ EL ++ +VL + L
Sbjct: 431 KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490
Query: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF---QEELS 401
R + +++ ++ +R+ + LE K E E +E L
Sbjct: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550
Query: 402 RQQRSFQTLDQECIQMKARLT---QELQQAKNMHNVLQAE-------------------L 439
+ L QE ++ A L Q + + + N L+ E L
Sbjct: 551 SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610
Query: 440 DKLTSVKQQLENNLEEFKQKLCR----AEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
DK+ +Q L+ LEE Q +C AEQA A Q+ E + E + ++N L++
Sbjct: 611 DKVGLNQQLLQ--LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
++ L+A+L++I++ + Q E + + + T L L ++ +QE E
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE-----EV 723
Query: 556 LKLAVADLE---KQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL 612
L AV + E +++ + L+ E + L ++L + L SA EL + E
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL-------QGLSSAKELLESSLFEA 776
Query: 613 KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 672
+++ ++ K + E + + KE +Q ++ CLK LE+D
Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR----CLK---------------LELDT 817
Query: 673 ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK--HQKEIENMCLK-TSQLT 729
E E + + ++LA E + K QK H+KE+ + K + +
Sbjct: 818 ERSQAE----------QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
Query: 730 GQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR-------------------DLLKSK 770
++L L+ L E M+ + ++ E E+++ + K +
Sbjct: 868 WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
+ L T Q+ L QQ + + + + +L+ Q A Q+
Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 831 RVD--SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
R D +L+ S Q DLQKQ E+L +++ EQ Q + ET Q +++
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET-QEYNRI 1046
Query: 889 QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLS 948
Q++ + + TLS +E KE+ L +L + Q E+ L++ + KEL
Sbjct: 1047 QKELEREK--ASLTLSLME-KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103
Query: 949 ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE 1008
E L E KE +E + L QE L+E+ AS E+ ++ +A +
Sbjct: 1104 ELLRQEVKE---------KEADFLAQEAQLLEELEASHITEQQ---LRASLWAQEAKAAQ 1151
Query: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK 1068
+ S + + E L Q+ A L+ Y A Q+ S+CE+R
Sbjct: 1152 LQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQ----------ALGSVCESRP 1201
Query: 1069 NEL----EQLKEAFAKEHQEFLTKLAFAEERNQNL-MLELETVQQALRSEMTDNQNNSKS 1123
EL + + E + + F +R L L E V AL D ++
Sbjct: 1202 -ELSGGGDSAPSVWGLEPDQNGARSLF--KRGPLLTALSAEAVASALHKLHQDLWKTQQT 1258
Query: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
L+++ K+++ + D E Q+ E Q+L+ + +N ++ +
Sbjct: 1259 RD--------VLRDQVQKLEERLTDTEAEKSQV------HTELQDLQRQLSQNQEEKSKW 1304
Query: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
E Q + + ++ +E+ E + L++ LR EL+ E++ E+E LQ + +
Sbjct: 1305 EGKQNSLESEL-MELHE--------TMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Query: 1244 D---LETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL 1300
L+ + ++ +G+ + ++ + +E S+ + A + +
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ-------ALQEQ 1408
Query: 1301 NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGEL 1360
EL+ E L+T+ R E + R +E+ K
Sbjct: 1409 GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK------------------- 1449
Query: 1361 VEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKI 1420
++ ++ + L LD + + L +++Q EL++ L+
Sbjct: 1450 ----------QREMQKAALELLSLDLKKRNQEVDLQQEQIQ----ELEKCRSVLEHLPMA 1495
Query: 1421 LHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSC 1480
+ ++ +++ + +++ + + VL L + K+ + + G V L
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELE---KKDQMIESQRGQVQDLKKQL 1552
Query: 1481 VPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKE 1540
V L + + ++ +Q L+ LEG Q V + L + R +
Sbjct: 1553 VTLECLALEL-EENHHKMECQQ----KLIKELEG-----QRETQRVALTHLTLDLEERSQ 1602
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
A + + +LES V + L++ +++++SQ ++I+EL++ Q+L+ +
Sbjct: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQ----REQIEELQRQKEHLTQDLERRDQ 1658
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
+ + + E+ Q T ++K+ E + +LSL L Q + R+ G
Sbjct: 1659 ELMLQKERIQVLEDQRT--RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 1661 EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE 1720
A +G E + + E +H +H++ Q+L +E+ + G + GE
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEH-IHEL------QELKDQLEQQLQ-GLHRKVGE 1768
Query: 1721 CS-----GEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1775
S EQ + E + QG + E S +++ LQ
Sbjct: 1769 TSLLLSQREQEIVVLQQQLQEAREQGE---LKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL--HLQEVQLMTKIEACIE------ 1827
++ + R+ + +E +KE +L H ++ + + + E +E
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQA 1884
Query: 1828 LEKIVGELKKENSDLSEKLEYF--SCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
LE+++G+L+ E+ + + L C Q VET +S L+ A R
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER------ 1938
Query: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
+ EL +R+E S H+ A E +Q + K++
Sbjct: 1939 ---------------DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
Query: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
++ E + + L+ LD + L++ + + Q+ + E + +Q A
Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
Query: 2006 EAE-------VKEKTELLQ-TLSSDVSE-LLKDKTHL-----QEKLQSLEKDSQALSLTK 2051
A+ +E+ +LL+ +L+ V E ++++K +L +E+++ L + + L LT
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
Query: 2052 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAAL---VEKGEFALRLS 2108
+ E +I +L + ++ E+ + S + + L + +LE L +E+ + ALR +
Sbjct: 2104 AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLD-SLEPRLQRELERLQAALRQT 2162
Query: 2109 ST-----QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2163
+E+ L + + + + + ++ + + + ER+ E L+D++E R L
Sbjct: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL 2222
Query: 2164 QMSEENQELVILDAE-NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
+ + AE S+ E ++ + ++ + R E+L + +
Sbjct: 2223 EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
Query: 2223 QGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIM 2282
+ S L + +S LE+ E+ ++K E+ AA G EI
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMR----------------AAQAGSLEIS 2326
Query: 2283 KATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ-QLKESEHHADLLKGRVENL 2341
KAT S P ++ +NS K A L+ K++ +LQ QL R
Sbjct: 2327 KATASS--PTQQDGRGQKNSDAKCVAELQ----KEVVLLQAQLTLERKQKQDYITRSAQT 2380
Query: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKI----EGMTQSL 2380
REL + H+ L + E L+A+ E +TQSL
Sbjct: 2381 SRELAGLHHSLSHSLLAVAQAP-EATVLEAETRRLDESLTQSL 2422
Score = 158 bits (399), Expect = 9e-38
Identities = 271/1217 (22%), Positives = 521/1217 (42%), Gaps = 177/1217 (14%)
Query: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM--KELDSKLHLQEVQLMTKIE 1823
+E + LQ ++ E + R L ++ ++ +L+ ++ K L + QE++
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEK----- 75
Query: 1824 ACIELEKIVGELKKENSDLSE-KLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS--RE 1880
LE G + + ++ E L+ +E QR E+ +N+ L +H +K+ +
Sbjct: 76 ---RLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK 132
Query: 1881 DIGDNVAKVNDSWKERFLDVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLC 1934
+ ++V K+ W ++ + S+ + E+ EH L L EVV +
Sbjct: 133 ALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL-LSLWREVVTFRRHF 191
Query: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEK----------- 1983
LE + + +L + +E +L G L T + T Q E
Sbjct: 192 LEMKSAT--------DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREP 243
Query: 1984 -----MKEKTQELESHQSE-CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037
+ KTQELE E IQ+ EK EL Q +++S LL T Q++
Sbjct: 244 AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAEL-QDRVTELSALL---TQSQKQN 299
Query: 2038 QSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAAL 2097
+ EK +AL T LE +L + + L + ++ + L + V K + +
Sbjct: 300 EDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQ-------VIKDITQVM 352
Query: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE 2157
VE+G+ + S E +L I +AD K L + + R R+ V+
Sbjct: 353 VEEGD-NIAQGSGHENSLELDSSIFSQFDYQDAD--KALTLVRSVLTRRRQ------AVQ 403
Query: 2158 NLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK 2217
+L ++L +E L+ + + E + L+ +++++ V L+ E ++L+K
Sbjct: 404 DLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK 463
Query: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG 2277
+ + Q EL + L + + ++++ + +A + Q +EL+ AV
Sbjct: 464 ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERER 523
Query: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR 2337
QE++ E + E LR ++E E ++Q V L +E L
Sbjct: 524 LQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSS 583
Query: 2338 VENLERELEIART-------------------NQEHAALEAENSKGEVETLKAKIEGMTQ 2378
L+ E+ R NQ+ LE EN +++ +++E Q
Sbjct: 584 ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN-----QSVCSRMEAAEQ 638
Query: 2379 SLRGLELDVVTIRSEKE-------NLTNELQKEQERISELEIINSSFENILQEKEQ---- 2427
+ L++D+ +E +L +LQK +E +EL+ + +I +EKE+
Sbjct: 639 ARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ---ADLRDIQEEKEEIQKK 695
Query: 2428 --EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK--- 2482
E +E ++T +E L + K E +A ++EA ++ L +++ +E ++
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQE---VEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
A+ LQGL AK +L+SS+ Q+ +E K +LE + + +++ K IQ + + +
Sbjct: 756 AEQLQGLSSAKE---LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL- 811
Query: 2540 KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN------- 2592
KL Q +E++ R L ++ L+ + A+ + + L+ ++
Sbjct: 812 KLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ 871
Query: 2593 -LENELELTKMDKMSFVEKVNKMTAK--ETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
L LE + +KM ++ + + + QRE ++A Q +L EK R++
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS-- 929
Query: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709
LLE + ++ +L + + + L++ + + E G ++ ++ E Q L EA ++
Sbjct: 930 ---LLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA---TTQI 2766
H R+ L + +E SS + L+ E+L + L A + ++
Sbjct: 987 H------------------RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Query: 2767 LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ----LEEEKEILQKELSQL--- 2819
+E+ + K+ + N+++KE ER + + L + +Q L+E I Q+ELS L
Sbjct: 1029 VEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
Query: 2820 -QAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
Q AQ +QK EL+ +++ L++ E K KEAD +L + LL E+LE A
Sbjct: 1089 MQEAQGEQK----------ELSAQMELLRQ--EVKEKEAD-FLAQEAQLL---EELE-AS 1131
Query: 2879 EMLETQV-AHLCSQQSK 2894
+ E Q+ A L +Q++K
Sbjct: 1132 HITEQQLRASLWAQEAK 1148
Score = 127 bits (319), Expect = 2e-28
Identities = 214/1047 (20%), Positives = 426/1047 (40%), Gaps = 151/1047 (14%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKR---------- 67
++++ L GQ+ +L+K+++ ++ L+ L L+K+ Q+V+ ++ + L++
Sbjct: 1435 EEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPM 1494
Query: 68 -----------ENQRLMEICESLEKTKQKISH---ELQVKESQVNFQEGQLNSGKKQIEK 113
+ +++ E+ + E + + H EL+ K+ + Q GQ+ KKQ+
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT 1554
Query: 114 LE---QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLT-------PSQYYSGSK 163
LE EL+ ++E Q+ + L Q++ T LT S+
Sbjct: 1555 LECLALELEENHHKMECQQKLIK----ELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 164 YEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEK 223
DL+ E + + EVK+ Q ++ + Q +D+ R + Q+E+
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKS-QREQIEELQRQKEHLTQDLERRDQELML---QKER 1666
Query: 224 TPSHLSSNSQRTPIRRD----FSASYFSGEQEVTPSRSTLQIGKRDANS-SFFDNSSSPH 278
+++T I + S +E+T R +Q + S S H
Sbjct: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
Query: 279 ------------------------LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
L DQL+ Q Q L K+ E L L E+E+
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI------ 1780
Query: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
LQ QL++A+ + KE+ L DE R AQ DQ + AL+Q+ ++
Sbjct: 1781 -VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEALQQEQQQAQGQEERV 1836
Query: 375 RQNAESARCSLEQ---KIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNM 431
++ A++ + +LEQ +KE+ E Q+ + +R L++E + ++ R Q L++
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARR----LEEE-LAVEGRRVQALEEVLGD 1891
Query: 432 HNVLQAELDK-LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
E +K L +++QQ +E + + + ++ +Q E + +E ++ E+
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 491 LKSHSEQKAR--------EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQE 542
+ H E+ AR + A L+ +Q L + + ++A + + L Q
Sbjct: 1952 SR-HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQA 2010
Query: 543 KINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQLNDKLSKTEKE-SKALL 599
Q E +L +++ ++ DL Q D Q L +R+ + ++ EK ++ +
Sbjct: 2011 HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
Query: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
+ +K+ + +EE+ + +S E LT + E+E L+ + +TQQ +
Sbjct: 2071 ENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR--------ETQQRNNL 2122
Query: 660 E-YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEI 718
E +T M+ ++L LDS ++ + ++ E + + +++
Sbjct: 2123 EALPHSHKTSPMEEQSLK---------LDSLEPRLQRELERLQAALRQTEAREIEWREKA 2173
Query: 719 ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
+++ L +Q V L+ L ++++D Q L E E R L+ K+
Sbjct: 2174 QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE-KERLHSPGA 2232
Query: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838
L + +Q +GE + +E S +E + LQ V LE
Sbjct: 2233 TSTAELGSRGEQGVQ-------LGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID 2285
Query: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
++ N L+ E++ + + +++ M+A Q +++ + S Q+D +N
Sbjct: 2286 RSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATAS-SPTQQDGRGQKNS 2344
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQ-----------ELKKSNHLLEDSLKELQLL 947
A+ ++ L +KE+ LL ++ E+ + Q EL +H L SL +
Sbjct: 2345 DAKCVAEL---QKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQA 2401
Query: 948 SETLSLEKKEMSSIISLNKREIEELTQ 974
E LE + +R E LTQ
Sbjct: 2402 PEATVLEAE--------TRRLDESLTQ 2420
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 243 bits (619), Expect = 3e-63
Identities = 529/2620 (20%), Positives = 1059/2620 (40%), Gaps = 373/2620 (14%)
Query: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA-EEMKAKNTSQETMLRDLQEK 543
K E N LKS +K V HL +++ + Q A EE++ Q L+ K
Sbjct: 34 KVEVNELKS---EKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTK 90
Query: 544 INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
+ + EN L + + D R+ L K+ E +L D + EKE K + L
Sbjct: 91 VMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK-VNEQLA 149
Query: 604 LKKKEYEE-----LKEEKTLFSCWKSENEKLL-------TQMESEKENLQSK---INHLE 648
L+ +E E +E K L K +NE+L Q++S+KE L S+ +
Sbjct: 150 LRNEEAENENSKLRRENKRL----KKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYR 205
Query: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE 708
+ L + + +Y + ++TL E + V+ + + L+ E+E Y ++
Sbjct: 206 SQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVH 265
Query: 709 FSD---QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD 765
+D + +KE ++ L+ +LT LL ++ + D ++A+ E +
Sbjct: 266 QTDNVIDQLKKENDHYQLQVQELT----------DLLKSKNEEDDPIMVAVNAKVEEWKL 315
Query: 766 LLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNS 825
+L SKD ++ + Q +H ++ + +L+AD+S N
Sbjct: 316 ILSSKDDEII------------EYQQMLH-----------NLREKLKNAQLDADKS--NV 350
Query: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRI 885
LQ + ++ +S ++ E++ Q E+E+N E + + ++
Sbjct: 351 MALQQGI----------QERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNEL--QRNKGA 398
Query: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE-IQELKKSNHLLEDSLKEL 944
S L + T + TL L+ K KE + + E + E +EL ++ L+D +
Sbjct: 399 STLSQQTHMK---IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGV 455
Query: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
L + + +E K + I + REIE LT KEIN L + + + ++E+ +
Sbjct: 456 YGLEDAV-VEIKNCKNQIKIRDREIEILT------KEIN-KLELKISDFLDENEALRERV 507
Query: 1005 DEREKSISELSD----------QYKQEKLILLQRCEETGNAYEDLSQKYK-AAQE--KNS 1051
K++ +L++ QY+ E ILL+ E DL +K + AQE K S
Sbjct: 508 GLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRS 567
Query: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR 1111
L E +L EN + ++ + L+ +E +++N L E +++
Sbjct: 568 ATSGLTTEDLNLTENISQ-----GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERD 622
Query: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
E S++ + ++ L EE ++++ + ++LQ +++ K K +L
Sbjct: 623 LE------RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLII 676
Query: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
+ V ES+ + F + L+ AQ+ QL RN+EL+ + E K
Sbjct: 677 PSLERLVNAIESKNAEGIFDASLHLK----------AQVDQLTG--RNEELRQELRESRK 724
Query: 1232 ECLQHELQTIRGDLETSNLQD----MQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN- 1286
E + + Q + +L+ +L+ ++ E S + ID + + SQN+
Sbjct: 725 EAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYL 784
Query: 1287 AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1346
HL L+ KL LE E K+ ++ R + ++ E E
Sbjct: 785 IHLLQELENKEKKLKNLEDSLEDYN-RKFAVI------RHQQSLLYKEYLSEKETWKTES 837
Query: 1347 KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE 1406
K + ++ L ++ +D ++ + +N L + E++ AE
Sbjct: 838 KTIKEEKRKLEDQVQQD----------------AIKVKEYNNLLNALQMDSDEMKKILAE 881
Query: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
K LQ K L Q+ + +L+ + K E L + + G L + ++
Sbjct: 882 NSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEM 941
Query: 1467 GLEEGLVPSLSSSCVPDSSSLSSLG-DSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525
+ + + +L V +S SLS L + Y L + D+ N+ ++N
Sbjct: 942 AIFK--IAAL-QKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSN------ 992
Query: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
L+ EN++ KE VE + E+ ++ L +E+ E + + N+ +
Sbjct: 993 --LEHLECENISLKEQ-------VESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
Query: 1586 QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE-MESKLAAEKKQTEQLSLELEVARLQ 1644
+ + + +K + E ++ ++ + + M L KQ E+ + ELE +
Sbjct: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAE 1103
Query: 1645 LQGLDLSSR---SLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1701
L ++L ++ +L + D++ D + E E K +V ++ +
Sbjct: 1104 LTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIAR 1163
Query: 1702 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS--ECISELSFSGPNALVP 1759
++I + K E + +Y+ ++K+ + + L S AL
Sbjct: 1164 RQVEILNAQQQSRDK---EVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGK 1220
Query: 1760 MDFLGN---QEDIHNLQLRVKETSNENLRLLHVIEDRDRKV---ESLLNEMKELDSKLHL 1813
++ + + + + +NL+L K E +E R+R +++ + ++ L L
Sbjct: 1221 LESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPL 1280
Query: 1814 --QEVQLMTKIEACIELEKIVGELKK--------ENSDLSEKLEYFSCDHQELLQRVETS 1863
QE T I+ + KI+ E+K EN L +L+ +EL+ ++ +
Sbjct: 1281 AQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL--EELISTLKDT 1338
Query: 1864 EGLNSDLEMH--ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
+G + H ++ +++ N V D KE + N +S +S+E
Sbjct: 1339 KGAQKVINWHMKIEELRLQELKLNRELVKD--KEEIKYLNNIISEYERTISSLEE----- 1391
Query: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
E+VQ K E+ Q+ V LE +L + ++N++ + T ++ S
Sbjct: 1392 ----EIVQQNKFHEERQMAWDQRE-VDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPS 1446
Query: 1982 -----------EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
K+KE + + ++ C + E ++KEK L+ ++ L +DK
Sbjct: 1447 LPLPNQLEIALRKIKENIRIILETRATC----KSLEEKLKEKESALRLAEQNI--LSRDK 1500
Query: 2031 -----------THLQEKL-------QSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072
T +EKL + K L + + N A+LN+++E+L K
Sbjct: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
Query: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
L+ E ++ V K E + L+ S+ + Q + K
Sbjct: 1561 RLLEKAREE---QREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
Query: 2133 KKQLHIAEKLKERERENDSLKD---KVENLERELQMSEENQELVILDAEN---------- 2179
K + +AE + ++DSL K++ + ++L+ E EL + + EN
Sbjct: 1618 KHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE 1677
Query: 2180 -----SKAEVETLKTQIEEMARSLKVFELDL------------VTLRSEKENLTKQIQEK 2222
KAEVE LK +++ + + + +L T+R+ E L Q+ K
Sbjct: 1678 DEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
Query: 2223 QGQLSELDKLLSSFKSLL----EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
+ Q L + L ++ + EE+ + KE +++ +EL V L +
Sbjct: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDL--N 1795
Query: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
+ ++K E +L E+ L +++ L L+ +K +L++ +E + D LK ++
Sbjct: 1796 ENLLKLKE-ALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQI 1854
Query: 2339 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT 2398
+ L L+ +N + +E L+ K++ + L G +++ V ++ KE
Sbjct: 1855 KRLTSGLQ--------GKPLTDNKQSLIEELQRKVKKLENQLEG-KVEEVDLKPMKEKNA 1905
Query: 2399 NELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM----------LQTQLK 2448
E E + + N L+EKE E + ++ +T ++ LQ +LK
Sbjct: 1906 KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLK 1965
Query: 2449 ELNERV------AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYI---VL 2499
V AL +++E + K++NL + + L + Q L ++ ++ L
Sbjct: 1966 TTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYL 2025
Query: 2500 QSSVNGLIQEVED---GKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL 2556
Q ++ L ++ K + + + + Q +E L +E + QL ++ N
Sbjct: 2026 QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQL-EQANK 2084
Query: 2557 E---LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
+ L+N +L++ + L+ + A +Q L ++ S ++ + EL K + ++KV +
Sbjct: 2085 DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEK--TIGLMKKVVE 2142
Query: 2614 MTAKETE---------LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE-EIKSSKDQ 2663
+E E +M + Q+ +L+ EL K L +L + E + K ++
Sbjct: 2143 KVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202
Query: 2664 LKELTLENSELKKSLDCMHKDQVEKEG------KVREEIAEYQLRLHEAEKKHQALLLDT 2717
+ E ELKK D K ++ K K+ ++ E RL AE + L
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262
Query: 2718 NKQYE--VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM 2775
+K ++ V + Y KL E ++ + I LK +E + + E+L++ ++
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQ-QI 2321
Query: 2776 DNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ-KTGTVMDT 2834
LK+V + + + + ++++L + QL++EK L + Q++A +++ T+ D
Sbjct: 2322 KILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAEL---IHQIEANKDQSGAESTIPDA 2378
Query: 2835 -----KVDELTTEIK-------ELKETLEEKTKEAD---------------EYLDKYCSL 2867
K+ +L T++K LKE +++ KE + Y ++
Sbjct: 2379 DQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKN 2438
Query: 2868 LISHEKLEKAKEMLETQV-AHLCSQQSKQDSRGSPLLGPV 2906
++ EK++K E L ++ + + + + +D SP+ P+
Sbjct: 2439 ILLEEKVKKLSEQLGVELTSPVAASEEFEDEEESPVNFPI 2478
Score = 242 bits (618), Expect = 4e-63
Identities = 529/2633 (20%), Positives = 1067/2633 (40%), Gaps = 433/2633 (16%)
Query: 280 LDQLKAQNQE------------LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV 327
+++LK++ QE ++ K E+EL L+ EK + Q +L+ ++ K +
Sbjct: 37 VNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLEN 96
Query: 328 ELIEKEKVLNK-----CRDELVRTTAQYDQASTKYTALEQKL---KKLTEDLSCQRQNAE 379
EL ++ R+E+ + Q +Q + +E++L KK+ E L+ + + AE
Sbjct: 97 ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
Query: 380 SARCSLEQ---KIKEKEKE-------FQEELSRQQRSFQTLDQECIQMKARLTQ---ELQ 426
+ L + ++K+K ++ +Q+++ Q+ + + E +++L++ EL
Sbjct: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
Query: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Q + L +K+ Q++ NLEE Q++ + + + ++ ++++KK
Sbjct: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Query: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
EN+ H + + +E+ L +K + + AK + +L ++I +
Sbjct: 277 END----HYQLQVQELTDL------LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIE 326
Query: 547 QENSL--TLEKLKLAVADLEKQRDCS-QDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
+ L EKLK A D +K + Q +++R+ I+ L +++ + KE + +E
Sbjct: 327 YQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIE 386
Query: 604 LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNE 663
K E + K TL + + K+ + ++ KE + E + K E E
Sbjct: 387 DLKNELQRNKGASTLS---QQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
Query: 664 RVRTLE------MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
++ L+ E+ VEI+N N + + E+E KE
Sbjct: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILT------------------KE 485
Query: 718 IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD----LLKSKDAS 773
I + LK S + E L ++ L ++D H + + R LLK ++
Sbjct: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESL 545
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
D ++ + Q+ + + + E ++ S+ I + ++D
Sbjct: 546 EEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ----------GDRISERKLD 595
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
L SL++ + S + EL++ + ++E + ++ +A+ ++ +L E+
Sbjct: 596 LL--SLKNMSEAQSKNEFLSRELIEKERDLERS--------RTVIAKFQNKLKELVEENK 645
Query: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
+ + E L A++ +K+ + + L+ SL+ L ++
Sbjct: 646 QLEEGMKEILQAIKEMQKDPDVKGGETS--------------LIIPSLERL-----VNAI 686
Query: 954 EKKEMSSIISLN---KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
E K I + K ++++LT N L++ +E +N Q+ ID EK
Sbjct: 687 ESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKE 746
Query: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK----NSKLECLLNECTSLCEN 1066
S LL++ E + ++ + A NS+ E L++ L EN
Sbjct: 747 TS------------LLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQEL-EN 793
Query: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAG 1126
++ +L+ L+++ +++F A R+Q +L E + SE
Sbjct: 794 KEKKLKNLEDSLEDYNRKF------AVIRHQQSLLYKEYL----------------SEKE 831
Query: 1127 GLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186
K E T+KEE+ K++ +V Q++ +K ++S+ ++ + E
Sbjct: 832 TWKTESKTIKEEKRKLEDQV----QQDAIKVKEYNNLLNALQMDSDEMKKILAE------ 881
Query: 1187 QCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK-ECLQHELQTIRGDL 1245
N + L+V E SL LV+LE LR +E+EK+K E L E +
Sbjct: 882 --NSRKITVLQVNEKSLIRQYTTLVELERQLR------KENEKQKNELLSMEAEVCEKIG 933
Query: 1246 ETSNLQDMQSQEISGLK---DCEIDAEEKYISGP--HELSTSQNDNAHLQCSLQTTMNKL 1300
++M +I+ L+ D + E ++ +EL+ D L + L
Sbjct: 934 CLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNL 993
Query: 1301 NELEKICE-ILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGE 1359
LE CE I E+ E + + + E + + E+ KL NE + + + +
Sbjct: 994 EHLE--CENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD 1051
Query: 1360 LVED------IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLS 1413
+V + E E+ +H + YEHL S K+++ EL+ KF
Sbjct: 1052 IVSISKKITMLEMKELNERQRAEHCQKM--------YEHLRTSLKQMEERNFELETKFAE 1103
Query: 1414 L-------QSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
L Q ++L D+ SK D+ + L L N EM+L
Sbjct: 1104 LTKINLDAQKVEQMLRDELADSVSKAVS-----DADRQRILELEKN----------EMEL 1148
Query: 1467 GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
+E + +S L++ +Q+ D + S + S ++
Sbjct: 1149 KVEVSKLREISDIARRQVEILNAQ----------QQSRDKEVESLRMQLLDYQAQSDEKS 1198
Query: 1527 FCSSLQEENLTRKETPSAPAKGVEELESLC---EVYRQSLE-KLEEKMESQGIMKNKEIQ 1582
+ L + N++ + + + +E + S E Y LE KL+EK ++ + +
Sbjct: 1199 LIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
Query: 1583 ELEQLLSSERQELDCLRKQYLSENEQWQQ-KLTSVTLEMES---KLAAEKKQTEQLSLEL 1638
+ L RQ + LR+Q+ QQ K + +++++ K+ E K ++Q +
Sbjct: 1259 RAKHL----RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
Query: 1639 E----VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQIC 1694
E L+L+GL+ +L DT+ A + N I + E K + +
Sbjct: 1315 ENKTLEMELKLKGLEELISTLK--DTKGAQKVINWHMKIEELRLQEL-----KLNRELVK 1367
Query: 1695 DKDAQQDLNLDI-----------EKITETGAVKPTGECSGEQSP-DTNYEPPGEDKTQG- 1741
DK+ + LN I E+I + + + +Q D + D+ Q
Sbjct: 1368 DKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
Query: 1742 ---SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVE 1798
+++ E + S P+ +P L NQ +I +++ EN+R+ ++E R +
Sbjct: 1428 ILNAAQKFEEATGSIPDPSLP---LPNQLEIALRKIK------ENIRI--ILETR-ATCK 1475
Query: 1799 SLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
SL ++KE +S L L E ++++ +K++ EL+ +E+ E +
Sbjct: 1476 SLEEKLKEKESALRLAEQNILSR-------DKVINELRLRLPATAER-EKLIAELGRKEM 1527
Query: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
++ L + A+ +R + + V K E+ + + E+ + E I H
Sbjct: 1528 EPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHR 1587
Query: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLR-GELD-TMSKKTTA 1976
L L+AD + N+ KQ +++ + V + ++ +R E++ T++++ +
Sbjct: 1588 LELQADSSL-----------NKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS 1636
Query: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE----KTELLQTLSSDVSELLKDKTH 2032
L L K+K+ +Q+LE + ++ E +VKE K +L + +V ++ +
Sbjct: 1637 LSSLLVKLKKVSQDLERQR-------EITELKVKEFENIKLQLQENHEDEVKKVKAEVED 1689
Query: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES-ESLQARLSESDYEKLNVSK 2091
L+ L +K+SQ L K EL+ Q ++ ++ E L+++L+ + ++ +S+
Sbjct: 1690 LKYLLDQSQKESQCL---KSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSR 1746
Query: 2092 AL---EAALVEKGEFALRLSSTQEEVHQ-----LRRGIEKLRVRIEADEKKQLHIAEKLK 2143
AL A + E + +++Q+E H + R +L+ ++E + L + E LK
Sbjct: 1747 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK 1806
Query: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL----- 2198
+ +SL D + +L ELQ ++ ++ + E E + LK QI+ + L
Sbjct: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
Query: 2199 ------------------------KVFELDLVTLRSEK------------------ENLT 2216
KV E+DL ++ + E +
Sbjct: 1867 TDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926
Query: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTA---------VEMLQNQ--L 2265
+++EK+G++ L K L++ K L + ++ ++ ++ + KT + L+++ L
Sbjct: 1927 NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL 1986
Query: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQ 2323
+EL + L D M+A + + E+ L+N EKL A LE K
Sbjct: 1987 EELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHA-LEKQFSKDTYSKPS 2045
Query: 2324 L----------KESEHHADLLKGRVENLERELEIARTNQEHAAL--EAENSKGEVETLK- 2370
+ +E E + LK EN+E + ++ + N++ L + + K E LK
Sbjct: 2046 ISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKK 2105
Query: 2371 --AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS-ELEIINSSFENILQEKEQ 2427
A+++ +RG TI E E ++K E++ E E + + + EK
Sbjct: 2106 EKAEVQRKLGHVRGSGRSGKTI-PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA 2164
Query: 2428 EKVQMKEKSSTAMEMLQTQL-KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
Q EK +E L+ L +L+ + E A+ + L +++ ++
Sbjct: 2165 NIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELK----KETDAA 2220
Query: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI----SRLKNQIQDQEQLVSKLS 2542
+ L AKNN +L + ++E Q E + ++ S+ I +KL
Sbjct: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
Query: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
++E + + +L+ L E ++ Q + N L+ +++L+ + E E L +
Sbjct: 2281 ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE 2340
Query: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL-----LLEEI 2657
++ L+ H++ ++ AEL ++ K++ E + L E+I
Sbjct: 2341 LQV---------------LRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKI 2385
Query: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH 2710
K + QLK LE LK+ + + K+ + EEI + + E KK+
Sbjct: 2386 KDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKN 2438
Score = 212 bits (540), Expect = 4e-54
Identities = 530/2613 (20%), Positives = 1055/2613 (40%), Gaps = 505/2613 (19%)
Query: 26 QLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQK 85
++++LK EKQ+ L + +L K K + E E Q E L+ K
Sbjct: 36 EVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFE--NQLKTKVMK 93
Query: 86 ISHELQVKESQVN-----FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
+ +EL++ + F ++ +KQ+E+ ++EL+ + ELE+ ++ + +
Sbjct: 94 LENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALR-- 151
Query: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200
N + + L K E L + ++ +K+++++ + L +++ + ++
Sbjct: 152 --NEEAENENSKLRRENKRLKKKNEQLCQDI---IDYQKQIDSQKETLLSRRGEDSDYRS 206
Query: 201 TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQ 260
++ ++ Q + Q T ++ Q +R++ S QE+ + T +
Sbjct: 207 QLSKKNYELIQYLDEI----QTLTEANEKIEVQNQEMRKNLEESV----QEM--EKMTDE 256
Query: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE----MKGQVNKFQ 316
+ A DN ++DQLK +N + ++ EL L+ +E M K +
Sbjct: 257 YNRMKAIVHQTDN-----VIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVE 311
Query: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ-------KLKKLTE 369
E +L L E+IE +++L+ R++L AQ D + AL+Q ++K LTE
Sbjct: 312 EWKLILSSKDDEIIEYQQMLHNLREKL--KNAQLDADKSNVMALQQGIQERDSQIKMLTE 369
Query: 370 DLSCQRQNAESARCSLEQK---------------------------IKEKEKEFQEELSR 402
+ + E C +E +KEK KE +
Sbjct: 370 QVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAEL 429
Query: 403 QQRSFQTLDQECIQMKARLTQ-------------ELQQAKNMHNVLQAELDKLTSVKQQL 449
+ + D+E ++ RL E++ KN + E++ LT +L
Sbjct: 430 AEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKL 489
Query: 450 ENNLEEF--KQKLCRAEQAFQ-ASQIKENELRRS----MEEMKKENNLLKSHSEQKAREV 502
E + +F + + R + + I E R S ++ + EN +L E E
Sbjct: 490 ELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEER 549
Query: 503 CHLEAELKNIKQ----------CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
L+ +++ + Q + N E + + E L DL N E
Sbjct: 550 LDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKL-DLLSLKNMSEAQSK 608
Query: 553 LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL 612
E L + + E+ + S+ ++ K ++ +++L ++ + E+ K +L A++ +K+ +
Sbjct: 609 NEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVK 668
Query: 613 KEEKTLFSCWKSENEKLLTQMESEK-ENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD 671
E +L E+L+ +ES+ E + HL+ + ++ E + +R +
Sbjct: 669 GGETSLII---PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKE 725
Query: 672 RENLSVEIRNLHNVLDSKSVEVETQKLAYME---------------LQQKAEFSDQKHQ- 715
N S ++ + +D +E ET L E A + +++
Sbjct: 726 AINYSQQLAKANLKID--HLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEY 783
Query: 716 -----KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
+E+EN K L +ED K ++ ++ L+ EY S ++ K++
Sbjct: 784 LIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQ-------QSLLYKEYLSEKETWKTE 836
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
++ ++ +R L QQ A+ N + M S+ + ++ A+ S K + + N
Sbjct: 837 SKTI---KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMK-KILAENSRKITVLQVN 892
Query: 831 R---VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE---------------------- 865
+ +E ++Q+ + +KQ EL+ ++ E+ E
Sbjct: 893 EKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV 952
Query: 866 -----NLMKAEQMHQSFVAETSQRISKLQED------TSAHQNVVAETLSALENKE---K 911
+L + E ++ + T++ LQ+D TS +++ E +S E E K
Sbjct: 953 VDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINK 1012
Query: 912 ELQLLNDKVET-EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKK-EMSSIISLNKRE- 968
EL++ +K+ T EQA QE K N D K+ S+ +S+ KK M + LN+R+
Sbjct: 1013 ELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQR 1072
Query: 969 ----------------------------IEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
ELT+ N +++ L E + + K+ S
Sbjct: 1073 AEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSD 1132
Query: 1001 AN--YIDEREKS----------ISELSDQYKQEKLILLQRCEETGNAYEDLSQK---YKA 1045
A+ I E EK+ + E+SD +++ IL + + E L + Y+A
Sbjct: 1133 ADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT-KLAFAEERNQNLMLELE 1104
++ S + L SL QL EA A E +T KL E N L +L+
Sbjct: 1193 QSDEKSLIAKLHQHNVSL---------QLSEATALGKLESITSKLQKMEAYNLRLEQKLD 1243
Query: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE---------EQNKMQKEVNDLLQENEQ 1155
+QAL + +N +K L+Q I +L+ +Q K K + L + +
Sbjct: 1244 EKEQALYYARLEGRNRAKH----LRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLK 1299
Query: 1156 LMKVMK-TKHECQNLES------------EPIRNSVKERESERNQCNFKPQM-DLEVKEI 1201
+M+ MK ++ E +N+E+ E + +++K+ + + N+ ++ +L ++E+
Sbjct: 1300 IMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL 1359
Query: 1202 SLDSYNAQLVQLEAMLRNKELKLQESEK-----EKECLQ----HELQTIRGDLETSNLQ- 1251
L N +LV+ + ++ + E E+ E+E +Q HE + + D +L+
Sbjct: 1360 KL---NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLER 1416
Query: 1252 -----DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKI 1306
D Q EI ++A +K+ + + + L L+ + K+ E +I
Sbjct: 1417 QLDIFDRQQNEI-------LNAAQKF---EEATGSIPDPSLPLPNQLEIALRKIKENIRI 1466
Query: 1307 CEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPG 1366
+A L +L + S A + + K++NE++ L + +L+ ++
Sbjct: 1467 ILETRATCKSLEEKLKEKESALRLAEQNILSR-DKVINELR-LRLPATAEREKLIAEL-- 1522
Query: 1367 GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHC 1426
G +P H + +A +N L +EV + L EK Q E H++
Sbjct: 1523 GRKEMEPKSHHTLKIAHQTIANMQARLN-QKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
Query: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQ---GDLVKEMQLGLEEGLVPSLSSSCVPD 1483
+ ELQ ++L F+ DL+K+ S + VP
Sbjct: 1582 HILHHRLELQA------------DSSLNKFKQTAWDLMKQ-------------SPTPVPT 1616
Query: 1484 SSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPS 1543
+ L + +EQT ++ + ++S+ + +V ++ +T +
Sbjct: 1617 NKHFIRLAE-------MEQT-----VAEQDDSLSSLLVKLKKVSQDLERQREITELK--- 1661
Query: 1544 APAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL 1603
V+E E++ +++ E +K+++ E+++L+ LL ++E CL+ +
Sbjct: 1662 -----VKEFENIKLQLQENHEDEVKKVKA-------EVEDLKYLLDQSQKESQCLKSELQ 1709
Query: 1604 SENEQWQQKLT----SVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGID 1659
++ E + T ++ ++S+LA ++KQ + LS L L R+ +
Sbjct: 1710 AQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRAL-----------LELRAEMTAA 1758
Query: 1660 TEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ------QDLNLDIEKITETG 1713
E+ I S T+++ +V QI D+ + +DLN ++ K+ E
Sbjct: 1759 AEERI-------------ISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL 1805
Query: 1714 AVKPTGECS-GEQSPDTNYEPPGEDKT------------QGSSECISELS--FSGPNALV 1758
E S + D N E + K Q + E ++ SG
Sbjct: 1806 KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP 1865
Query: 1759 PMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQL 1818
D Q I LQ +VK+ N+ +E + +V+ L MKE ++K L +
Sbjct: 1866 LTD--NKQSLIEELQRKVKKLENQ-------LEGKVEEVD--LKPMKEKNAKEELIRWEE 1914
Query: 1819 MTKIEACIE-----LEKIVGELKKENSDLSEKLEYFS-CDHQEL-LQRVETSEGLNSD-- 1869
K +A IE L++ GE+ L+ + F+ D ++L LQR + G+ D
Sbjct: 1915 GKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQV 1974
Query: 1870 LEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQ 1929
L + A +S +E + K+R LD+EN++ +R+ H+AL ++ +E
Sbjct: 1975 LGIRALESEKE---------LEELKKRNLDLENDILYMRA------HQALPRDSVVE--- 2016
Query: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG-ELDTMSKKTTALDQLSEKMKEKT 1988
L N Q+ + LE++ S T + + G E D ++ L + + K+ +
Sbjct: 2017 ----DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSEN 2072
Query: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
EL+ + + + +V++ E+ + L K+K +Q KL + + S
Sbjct: 2073 IELKFQLEQANKDLPRLKNQVRDLKEMCEFLK-------KEKAEVQRKLGHV-RGSGRSG 2124
Query: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
T ELE I + K E + +E+E L+ KA EK ++
Sbjct: 2125 KTIPELEKTIGLMKKVVEKVQRENEQLK--------------KASGILTSEK------MA 2164
Query: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
+ ++E +L+ +EKL+ + + +H K K E+ + + E L +EL+ +
Sbjct: 2165 NIEQENEKLKAELEKLKAHL--GHQLSMHYESKTKGTEK----IIAENERLRKELKKETD 2218
Query: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFE-----LDLVTLRSEKENLT-----KQ 2218
E + + N + E + Q+EE + L+ E L+ +S K + +
Sbjct: 2219 AAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETK 2278
Query: 2219 IQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
++E + +++ ++ ++ K L++E + E ++ + + E L+ Q+K L
Sbjct: 2279 LKELETDIAKKNQSITDLKQLVKEATEREQKVNKYN----EDLEQQIKILKHVPEG---- 2330
Query: 2279 QEIMKATEQSLDPPIE----EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLL 2334
TEQ L ++ HQL +L ++EA++ + + + AD L
Sbjct: 2331 ----AETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQ-----SGAESTIPDADQL 2381
Query: 2335 KGRVENLERELEIARTNQEHAALEAENSKGEVE 2367
K ++++LE +L+++ ++H E + K E+E
Sbjct: 2382 KEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE 2414
Score = 210 bits (535), Expect = 2e-53
Identities = 477/2296 (20%), Positives = 939/2296 (40%), Gaps = 386/2296 (16%)
Query: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN--KEKE 912
E+ ++K E +EN++ ++ QS + +Q + E+ E + EN K K
Sbjct: 36 EVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEK----AGEEQAKFENQLKTKV 91
Query: 913 LQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
++L N E E A+ + L + + +L+ E E ++M + K+ E+L
Sbjct: 92 MKLEN---ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
Query: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
N + N+ L +E L +K+E I + +K I +K LL R E
Sbjct: 149 ALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQID-------SQKETLLSRRGED 201
Query: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE-NRKNELEQLKEAFAKEHQEFLTKLAF 1091
+ LS +KN +L L+E +L E N K E++
Sbjct: 202 SDYRSQLS-------KKNYELIQYLDEIQTLTEANEKIEVQN------------------ 236
Query: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ 1151
+E +NL E+VQ+ +MTD N K+ I LK+E + Q +V
Sbjct: 237 -QEMRKNLE---ESVQE--MEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQV----- 285
Query: 1152 ENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLV 1211
++L ++K+K+E E +PI +V + E ++ L K+ + Y L
Sbjct: 286 --QELTDLLKSKNE----EDDPIMVAVNAKVEEW-------KLILSSKDDEIIEYQQMLH 332
Query: 1212 QLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEK 1271
L L+N +L +S LQ +Q ++ Q Q + C I+ +
Sbjct: 333 NLREKLKNAQLDADKS--NVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKN 390
Query: 1272 YISGPHELST-SQNDNAHLQCSLQTTMNKLNELEKICEILQA-------EKYELVTELND 1323
+ ST SQ + +Q +L K E E+ E+ +A E E + L D
Sbjct: 391 ELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKD 450
Query: 1324 SRS------ECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377
S + + + ++ E++IL + L ++ + + E +
Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLE 510
Query: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQT 1437
P ++ L E + +H L ++ + L ++ SL+ E L + QM+ + + ++
Sbjct: 511 PKTMIDLTEFRNSKH--LKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK-RS 567
Query: 1438 YVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYR 1497
L E+L L+ N+ QGD + E +L L LS + ++ S + R
Sbjct: 568 ATSGLTTEDLNLTENIS--QGDRISERKLDL-------LSLKNMSEAQSKNEF----LSR 614
Query: 1498 ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCE 1557
L+E+ D L ++ Q + E L EEN ++LE +
Sbjct: 615 ELIEKERD---LERSRTVIAKFQNKLKE-----LVEEN--------------KQLEEGMK 652
Query: 1558 VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSS-ERQELDCLRKQYLSENEQWQQKLTSV 1616
Q+++++++ + +G + I LE+L+++ E + + + L Q Q LT
Sbjct: 653 EILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQ-LTGR 711
Query: 1617 TLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL----------LGIDTEDAIQG 1666
E+ +L +K+ S +L A L++ L+ + L GID D I
Sbjct: 712 NEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAP 771
Query: 1667 RNES-CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQ 1725
+ S + E+ + + +D+ +D N I ++ S ++
Sbjct: 772 SSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKE 831
Query: 1726 SPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLR 1785
+ T + E+K + ++ + ++VKE +N
Sbjct: 832 TWKTESKTIKEEKRK------------------------LEDQVQQDAIKVKEYNN---- 863
Query: 1786 LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK 1845
LL+ ++ +++ +L E + L + E L+ + +ELE+ +L+KEN +
Sbjct: 864 LLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELER---QLRKENEKQKNE 920
Query: 1846 L---EYFSCDHQELLQRVE---------TSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
L E C+ LQR + + +++ + + + + + + AK D
Sbjct: 921 LLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDIL 980
Query: 1894 KERFLDVE--NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
++ + V+ + L + E S++ + + +LE+ + + +E+ E + K L
Sbjct: 981 QKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK----LGN 1036
Query: 1952 ELSVVTSERNQLRGELDTMSKKTTALD--QLSEKMK-EKTQELESHQSECLHCIQVAEAE 2008
E S+ ++++ ++ ++SKK T L+ +L+E+ + E Q++ H L ++ E
Sbjct: 1037 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFE 1096
Query: 2009 VKEKTELLQTLSSD---VSELLKDK----------THLQEKLQSLEKDSQALSLTKCEL- 2054
++ K L ++ D V ++L+D+ ++++ LEK+ L + +L
Sbjct: 1097 LETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR 1156
Query: 2055 ------ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
Q+ LN +++ KE ESL+ +L DY+ + K+L A L + +L+LS
Sbjct: 1157 EISDIARRQVEILNAQQQSRDKEVESLRMQL--LDYQAQSDEKSLIAKL-HQHNVSLQLS 1213
Query: 2109 STQ-----EEVHQLRRGIEKLRVRIE--ADEKKQLHIAEKLKERERENDSLKDKVENLER 2161
E + + +E +R+E DEK+Q +L+ R R L+ +++L R
Sbjct: 1214 EATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK-HLRQTIQSLRR 1272
Query: 2162 EL---------------QMSEENQELVIL-----------DAENSKAEVETLKTQIEEMA 2195
+ + +N +L I+ + EN E+E +EE+
Sbjct: 1273 QFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI 1332
Query: 2196 RSLK---------VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK---SLLEEK 2243
+LK + + + LR ++ L +++ + + ++ L+ ++S ++ S LEE+
Sbjct: 1333 STLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEE 1392
Query: 2244 EQAEIQIKEESKTAVEM----LQNQL----KELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
+ + EE + A + L+ QL ++ NE + A Q+ +AT DP +
Sbjct: 1393 IVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAA---QKFEEATGSIPDPSLPL 1449
Query: 2296 EHQLRNSIEKLRARLEAD-EKKQLC--VLQQLKESEHHADLLKGRVENLERELEIAR--- 2349
+QL ++ K++ + E + C + ++LKE E L + + + ++ + R
Sbjct: 1450 PNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRL 1509
Query: 2350 -TNQEHAALEAENSKGEVE-----TLK---AKIEGMTQSLRGLELDVVTIRSEKENLTNE 2400
E L AE + E+E TLK I M L E + + + L +
Sbjct: 1510 PATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKE----EVLKKYQRLLEK 1565
Query: 2401 LQKEQERI-----SELEIINSSFE----NILQEKEQEKVQMKEKSSTAMEMLQ--TQLKE 2449
++EQ I +L I++ E + L + +Q + ++S T + + +L E
Sbjct: 1566 AREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
Query: 2450 LNERVAALHNDQEACKAK----EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505
+ + VA + + K Q+L Q E EL+ + + + N+ + V
Sbjct: 1626 MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENH---EDEVKK 1682
Query: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQ----------------EQLVSKLSQVEGEHQ 2549
+ EVED K L++ +E LK+++Q Q E+L S+L+ E + +
Sbjct: 1683 VKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQK 1742
Query: 2550 LWKEQNLELR-NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2608
LELR +T E++I S+ + + +++ + L+ ++E + +
Sbjct: 1743 ALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLK 1802
Query: 2609 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
E + +E L ++++ + + Q+ N++ E + + +E K Q+K LT
Sbjct: 1803 EALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQENDELKRQIKRLT 1858
Query: 2669 --LENSEL---KKSLDCMHKDQVEK-EGKVREEIAEYQLR-LHEAEKKHQALLLDTNKQY 2721
L+ L K+SL + +V+K E ++ ++ E L+ + E K + + + K++
Sbjct: 1859 SGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKW 1918
Query: 2722 EVEIQTYREKLTSKEECLSSQKLEIDLL-----KSSKEELNNSLKATT------------ 2764
+ +I+ R KL KE + + +++ L K+ KE+L K T
Sbjct: 1919 QAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIR 1978
Query: 2765 -----QILEELKKTKMD---NLKY------------VNQLKKENERAQGKMKLLIKSCKQ 2804
+ LEELKK +D ++ Y V L +N Q K+ L K +
Sbjct: 1979 ALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSK 2038
Query: 2805 LEEEKEILQ--KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLD 2862
K + + Q QE QK +L++E ELK LE+ K+ +
Sbjct: 2039 DTYSKPSISGIESDDHCQREQELQKENL-------KLSSENIELKFQLEQANKDLPRLKN 2091
Query: 2863 KYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLS 2922
+ L E L+K K ++ ++ H+ RGS G +P + +K +
Sbjct: 2092 QVRDLKEMCEFLKKEKAEVQRKLGHV---------RGSGRSGKTIPELEKTIGLMKKVVE 2142
Query: 2923 SGQNKASGKRQRSSGI 2938
Q + + + +++SGI
Sbjct: 2143 KVQ-RENEQLKKASGI 2157
Score = 199 bits (507), Expect = 3e-50
Identities = 476/2395 (19%), Positives = 990/2395 (41%), Gaps = 403/2395 (16%)
Query: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESL 79
+ + + +D+LKKE Q Q+ L L K K + ++ N K E +L+
Sbjct: 264 VHQTDNVIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLI----LS 318
Query: 80 EKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSL 139
K + I ++ + + + QL++ K + L+Q ++ S++
Sbjct: 319 SKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQI-------------- 364
Query: 140 NPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK-ALQAKKASQTLP 198
K+ T + E+Y KE+E+ + ++K LQ K + TL
Sbjct: 365 -------KMLTEQV---------------EQYTKEMEKNTCIIEDLKNELQRNKGASTLS 402
Query: 199 QATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRST 258
Q T H S +EKT ++RT + A ++E+ +
Sbjct: 403 QQT--------HMKIQSTLDILKEKT-----KEAERTAELAEADAR--EKDKELVEALKR 447
Query: 259 LQIGKRDANSSFFDNSSS----PHLLDQLKAQNQE---LRNKINELELRLQ--------- 302
L +D S + + + +Q+K +++E L +IN+LEL++
Sbjct: 448 L----KDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
Query: 303 ----GHEKEMKGQVNKF---QELQLQLEKAKVELIEKE-KVLNKCRDELVRTTAQYDQAS 354
G E + + +F + L+ Q +A+ +++ KE + L + R +L + Q Q
Sbjct: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
Query: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
K +A TEDL+ ++ R S E+K+ + + +S Q + L +E
Sbjct: 564 GKRSATS---GLTTEDLNLTENISQGDRIS-ERKL---DLLSLKNMSEAQSKNEFLSREL 616
Query: 415 IQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
I+ + ++L++++ + Q +L +L +QLE ++E Q + ++ + +K
Sbjct: 617 IEKE----RDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAI---KEMQKDPDVKG 669
Query: 475 NELRRSMEEMKKENNLLKSHSEQKAREV-CHLEAELKNI---------------KQCLNQ 518
E + +++ N ++S + + + HL+A++ + K+ +N
Sbjct: 670 GETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINY 729
Query: 519 SQNFAE-EMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKR 577
SQ A+ +K + +ET L + Q E S + K + + S ++ +
Sbjct: 730 SQQLAKANLKIDHLEKETSL------LRQSEGSNVVFK---GIDLPDGIAPSSASIINSQ 780
Query: 578 EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT-LFSCWKSENEKLLTQMESE 636
++ L +L EK+ K L +LE +++ ++ +++ L+ + SE E T+ ++
Sbjct: 781 NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI 840
Query: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
KE + LE ++ IK EYN + L+MD + + K + ++
Sbjct: 841 KEEKRK----LEDQVQQDAIKVKEYNNLLNALQMDSDEM------------KKILAENSR 884
Query: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
K+ +++ +K+ E+E QL + E +++L + E+ +K C Q
Sbjct: 885 KITVLQVNEKSLIRQYTTLVELER------QLRKENEKQKNELLSMEAEVCEKIGCLQ-- 936
Query: 757 HAEYESLRDLLKSKDASLVTNEDHQRSL----LAFDQQPAMHHSFANIIGEQGSMPSERS 812
+++ K A+L D+ SL LA Q + + +I+ + + S
Sbjct: 937 -----RFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
Query: 813 EC-RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
LE + + L+ +V+S+ LE K+ +++ E+ ++ E + K +
Sbjct: 992 NLEHLECE-----NISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAK-K 1045
Query: 872 QMHQSFVAETSQRISKLQ-EDTSAHQNV--VAETLSALENKEKELQLLNDKVETEQAEIQ 928
+ S + S++I+ L+ ++ + Q + L K+++ N ++ET+ AE+
Sbjct: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELT 1105
Query: 929 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQ 988
++ +E L++ S + ++ + I+ L K E+ EL E L+EI+ +
Sbjct: 1106 KINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEM-ELKVEVSKLREISDIARR 1164
Query: 989 EKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL--------LQRCEETG-NAYEDL 1039
+ L + +S ++ + + Q ++ LI LQ E T E +
Sbjct: 1165 QVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
Query: 1040 SQKYKAAQEKNSKLECLLNECTSLCE----NRKNELEQLKEAFAKEHQEFLTKLAFA-EE 1094
+ K + + N +LE L+E +N + L++ ++F L A +E
Sbjct: 1225 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE 1284
Query: 1095 RNQNLMLELETVQQALRSEMTDNQNNSKS----------EAGGLKQEIMTLKEEQNKMQ- 1143
+ M++L+ + + EM ++Q ++ + GL++ I TLK+ + +
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV 1344
Query: 1144 ----KEVNDL-LQENEQLMKVMKTKHECQNL-----ESEPIRNSVKERESERNQCNFKPQ 1193
++ +L LQE + +++K K E + L E E +S++E ++N+ + + Q
Sbjct: 1345 INWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQ 1404
Query: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKE------------------CLQ 1235
M + +E+ L+ QL+ R + L ++K +E L+
Sbjct: 1405 MAWDQREVDLER------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALR 1458
Query: 1236 HELQTIRGDLET----SNLQDMQSQEISGLKDCEID-------------------AEEKY 1272
+ IR LET +L++ ++ S L+ E + EK
Sbjct: 1459 KIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKL 1518
Query: 1273 ISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT 1332
I+ + L+ + QT N L + E+L +KY+ + L +R E
Sbjct: 1519 IAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVL--KKYQRL--LEKAREEQREIV 1574
Query: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
+K E++ L + +++ D S + D+ P +H + LA ++++ + +
Sbjct: 1575 KKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQD 1634
Query: 1393 LTLS-----------DKEVQMHFAELQEK-----FLSLQSEHKILHDQHCQMSSKMSELQ 1436
+LS D E Q EL+ K L LQ H+ D+ ++ +++ +L+
Sbjct: 1635 DSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE---DEVKKVKAEVEDLK 1691
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
+D + E+ L + L+ Q + LV L S +L +
Sbjct: 1692 YLLDQSQKESQCLKSELQ-AQKEANSRAPTTTMRNLVERLKSQL-----ALKEKQQKALS 1745
Query: 1497 RALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLC 1556
RALLE +M+ + E +SA +S +E +L ++ + EL++
Sbjct: 1746 RALLELRAEMTAAAE-ERIISA----------TSQKEAHLNVQQIVD---RHTRELKTQV 1791
Query: 1557 EVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL----------SEN 1606
E ++L KL+E +++ KN+E L L+ EL +K Y EN
Sbjct: 1792 EDLNENLLKLKEALKTS---KNRE-NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
Query: 1607 EQWQQKLTSVTLEMESKLAAEKKQT--EQLSLELEVARLQLQG----LDL-------SSR 1653
++ ++++ +T ++ K + KQ+ E+L +++ QL+G +DL +
Sbjct: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
Query: 1654 SLL----GIDTEDAIQG-RNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEK 1708
L+ G + I+G RN+ + E + T + D+ DK EK
Sbjct: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK----------EK 1957
Query: 1709 ITETGAVKPTG----ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLG 1764
+T +K TG + G ++ ++ E E+ + + + +++ + + +P D +
Sbjct: 1958 LTLQRKLKTTGMTVDQVLGIRALESEKEL--EELKKRNLDLENDILYMRAHQALPRDSVV 2015
Query: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTK--- 1821
+ N L+ K LH +E + K + ++S H Q Q + K
Sbjct: 2016 EDLHLQNRYLQEK---------LHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
Query: 1822 ------IEACIELE---KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSD--- 1869
IE +LE K + LK + DL E E+ + E+ +++ G
Sbjct: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
Query: 1870 -LEMHADKSSREDIGDNVAKVNDSWK--------ERFLDVENELSRIRSE----KASIEH 1916
E+ + + + V + N+ K E+ ++E E ++++E KA + H
Sbjct: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGH 2186
Query: 1917 EALYLEADLEVVQTEKLCLEKDNENKQ-KVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975
+ L + + + TEK+ E + K+ K E+L + + L ++ ++T
Sbjct: 2187 Q-LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG 2245
Query: 1976 ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE-KTELLQTLSS--DVSELLKDKTH 2032
Q +E + + +S + + ++ E ++KE +T++ + S D+ +L+K+ T
Sbjct: 2246 KRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATE 2305
Query: 2033 LQEKLQSLEKD-SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSK 2091
++K+ +D Q + + K E + ++EL V L+ + D EK +
Sbjct: 2306 REQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQV-----LRLANHQLDKEKAELIH 2360
Query: 2092 ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE--- 2148
+EA + G ST + QL+ I+ L +++ + ++ H+ E++K+ ++E
Sbjct: 2361 QIEANKDQSG-----AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELEN 2415
Query: 2149 -NDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
+ S +++E+L + EE ++ ++L+ E K E L ++ + + FE
Sbjct: 2416 FDPSFFEEIEDL--KYNYKEEVKKNILLE-EKVKKLSEQLGVELTSPVAASEEFE 2467
Score = 171 bits (432), Expect = 1e-41
Identities = 297/1429 (20%), Positives = 592/1429 (41%), Gaps = 236/1429 (16%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAAL-------QKQKQKVENEK 59
E KE + + Q++ L K+ ++R F+L++ A L QK +Q + +E
Sbjct: 1063 EMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDEL 1122
Query: 60 TEGTNLK---RENQRLMEICESLEKTKQKISHELQVKE---SQVNFQEGQLNSGKKQIEK 113
+ + + QR++E+ ++ + K ++S ++ + QV Q S K++E
Sbjct: 1123 ADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVES 1182
Query: 114 LEQELKRCKSELERSQQAAQ----SADVSLNPCNTPQKI--FTTPLTPSQYYSGSKYEDL 167
L +L +++ + A+ + + L+ K+ T+ L + Y+ + L
Sbjct: 1183 LRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL 1242
Query: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEK-TPS 226
EK ++ RLE +A ++ Q+L R Q S ++ QQEK + +
Sbjct: 1243 DEK--EQALYYARLEGRNRAKHLRQTIQSL-----------RRQFSGALPLAQQEKFSKT 1289
Query: 227 HLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQI-----GKRDANSSFFDNSSSPHLL- 280
+ + + I ++ S ++ TL++ G + S+ D + ++
Sbjct: 1290 MIQLQNDKLKIMQEMKNSQ---QEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVIN 1346
Query: 281 -----DQLKAQ----NQEL----------RNKINELELRLQGHEKEMKGQVNKFQELQLQ 321
++L+ Q N+EL N I+E E + E+E+ Q +E Q+
Sbjct: 1347 WHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA 1406
Query: 322 LEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY--------TALEQKLKKLTEDLSC 373
++ +V+L + + ++ ++E++ ++++A+ LE L+K+ E++
Sbjct: 1407 WDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRI 1466
Query: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
+ + + SLE+K+KEKE L +++ + D+ +++ RL ++ K
Sbjct: 1467 ILETRATCK-SLEEKLKEKESA----LRLAEQNILSRDKVINELRLRLPATAEREK---- 1517
Query: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENN-LLK 492
L AEL + ++ + + L+ Q + + + + +R +E+ ++E ++K
Sbjct: 1518 -LIAELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVK 1575
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQET-----MLRDLQEKINQQ 547
H E + H EL+ Q + MK T T L ++++ + +Q
Sbjct: 1576 KHEEDL--HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQ 1633
Query: 548 ENSLT--LEKLKLAVADLEKQRDCSQ------------------DLLKKREHHIEQLNDK 587
++SL+ L KLK DLE+QR+ ++ D +KK + +E L
Sbjct: 1634 DDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYL 1693
Query: 588 LSKTEKESKALLSALELKKKE------------YEELKEEKTLFSCWKSENEKLLTQMES 635
L +++KES+ L S L+ +K+ E LK + L + + L ++ +
Sbjct: 1694 LDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA 1753
Query: 636 E-----KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL----------SVEIR 680
E +E + S + E L QQI E +E ENL
Sbjct: 1754 EMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNREN 1813
Query: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ--------- 731
+L + L+ + E++ ++ AY ++ ++ E DQ++ + + TS L G+
Sbjct: 1814 SLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSL 1873
Query: 732 VEDLEHKLQLLSNEI-----------MDKDRCYQDL---------HAEYESLRDLLKSKD 771
+E+L+ K++ L N++ M + ++L A+ E +R+ LK K+
Sbjct: 1874 IEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE 1933
Query: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
+ T Q + FA E+ ++ + + DQ +L R
Sbjct: 1934 GEVFT---------LTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQ------VLGIR 1978
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK-LQE 890
E LE K+ N DL+ + + +++++ + ++ E + K +
Sbjct: 1979 ALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSK 2038
Query: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ-ELKKSNH---LLEDSLKELQL 946
DT + ++ +E+ELQ N K+ +E E++ +L+++N L++ +++L+
Sbjct: 2039 DTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
Query: 947 LSETLSLEKKE--------------------MSSIISLNKREIEELTQENGTLKEINASL 986
+ E L EK E + I L K+ +E++ +EN LK+ + L
Sbjct: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
Query: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
EKM AN E EK +EL EKL + YE ++ +
Sbjct: 2159 TSEKM---------ANIEQENEKLKAEL------EKL-KAHLGHQLSMHYESKTKGTEKI 2202
Query: 1047 QEKNSKLECLLNECTSLCEN---RKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL---- 1099
+N +L L + T E KN LE L E + +E +L FAE R L
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262
Query: 1100 ------MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
++ + L+ TD ++S LKQ + E + K+ K DL Q+
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITD-LKQLVKEATEREQKVNKYNEDLEQQI 2321
Query: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
+ L V + Q L+ E + + ++ + Q++ + +S QL
Sbjct: 2322 KILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQL 2381
Query: 1214 EAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLK 1262
+ +++ E +L+ S+ EK+ L+ E++ ++ +LE N +EI LK
Sbjct: 2382 KEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE--NFDPSFFEEIEDLK 2428
Score = 129 bits (324), Expect = 5e-29
Identities = 265/1172 (22%), Positives = 497/1172 (42%), Gaps = 215/1172 (18%)
Query: 1875 DKSSREDIGDNV------AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
D +E++ DN+ +VN+ E+ EN + R ++ ++ +A +E LE V
Sbjct: 17 DLPRQEELADNLLISLSKVEVNELKSEK---QENVIHLFRITQSLMKMKAQEVELALEEV 73
Query: 1929 QTEKLCLEK---DNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985
EK E+ +N+ K KV+ LE EL + Q G DT + + QL ++++
Sbjct: 74 --EKAGEEQAKFENQLKTKVMK-LENELEMA----QQSAGGRDTRFLRNE-ICQLEKQLE 125
Query: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELL-QTLSSDVSELLKDKTHLQEKLQSLEKD- 2043
+K +ELE + E E +V E+ L + ++ S+L ++ L++K + L +D
Sbjct: 126 QKDRELEDMEKEL-----EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI 180
Query: 2044 ----------SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS--- 2090
+ L + E + +QL+K+ L++ + +Q L+E++ EK+ V
Sbjct: 181 IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQT-LTEAN-EKIEVQNQE 238
Query: 2091 --KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE 2148
K LE ++ E + + + VHQ I++L+ + + + + + LK + E
Sbjct: 239 MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE 298
Query: 2149 ND----SLKDKVENLERELQMSEENQELV----------------ILDAENSKAEVETLK 2188
+D ++ KVE E +L +S ++ E++ LDA+ K+ V L+
Sbjct: 299 DDPIMVAVNAKVE--EWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD--KSNVMALQ 354
Query: 2189 TQIEEMARSLKVF--ELDLVTLRSEK-----ENLTKQIQEKQGQ-----------LSELD 2230
I+E +K+ +++ T EK E+L ++Q +G S LD
Sbjct: 355 QGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLD 414
Query: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE-------LNEAVAALCGDQEIMK 2283
L K E AE +E+ K VE L+ +LK+ L +AV + + +K
Sbjct: 415 ILKEKTKEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKNQIK 473
Query: 2284 ATEQSLDPPIEEEHQLRNSI-------EKLRARLEADEKKQLCVLQQLKESEHHADLLKG 2336
++ ++ +E ++L I E LR R+ E K + L + + S+H LK
Sbjct: 474 IRDREIEILTKEINKLELKISDFLDENEALRERVGL-EPKTMIDLTEFRNSKH----LKQ 528
Query: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
+ E ++ + E E+ + E LK KI M Q RG + +E N
Sbjct: 529 QQYRAENQILLK---------EIESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLN 578
Query: 2397 LTNELQKEQERISELEIINSSFENILQEKEQ---------EKVQMKEKSSTAMEMLQTQL 2447
LT + + +RISE ++ S +N+ + + + EK + E+S T + Q +L
Sbjct: 579 LTENI-SQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKL 637
Query: 2448 KELNERVAALHNDQ----EACK--AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
KEL E L +A K K+ ++ L + + L E+KN + +
Sbjct: 638 KELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDA 697
Query: 2502 SVN-------------GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
S++ L QE+ + +++ +++++ +I E+ S L Q EG +
Sbjct: 698 SLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSN 757
Query: 2549 QLWK-----------------EQNLELRNLTVELEQKIQVLQSKNASLQD---------- 2581
++K QN L +L ELE K + L++ SL+D
Sbjct: 758 VVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH 817
Query: 2582 TLEVLQSSY----KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637
+L Y + + E + K +K ++V + K E ++ + + E+++
Sbjct: 818 QQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKK 877
Query: 2638 ELSGEKNRLAGELQL----LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
L+ E +R LQ+ L+ + + + ++L EN + K L M + EK G ++
Sbjct: 878 ILA-ENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQ 936
Query: 2694 --EEIAEYQLRLHEAEKKHQALLLD---TNKQYEVEIQTYRE------KLTSKEECLSSQ 2742
+E+A +++ + + L + NKQY YR+ L + L
Sbjct: 937 RFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHL 996
Query: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSC 2802
+ E LK E +N L+ T + L +++ + + K NE + K K I +
Sbjct: 997 ECENISLKEQVESINKELEITKEKLHTIEQA------WEQETKLGNESSMDKAKKSITNS 1050
Query: 2803 KQLEEEKEIL---QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
+ K+I KEL++ Q A+ QK + L T +K+ +EE+ E +
Sbjct: 1051 DIVSISKKITMLEMKELNERQRAEHCQK-------MYEHLRTSLKQ----MEERNFELE- 1098
Query: 2860 YLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
K+ L + +K ++ML ++A S+
Sbjct: 1099 --TKFAELTKINLDAQKVEQMLRDELADSVSK 1128
Score = 106 bits (264), Expect = 4e-22
Identities = 141/645 (21%), Positives = 301/645 (46%), Gaps = 83/645 (12%)
Query: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRAR-LEADEKKQLCVLQQLKESEHHADLLKGR 2337
+EIMK L E L S+ K+ L++++++ + L ++ +S L+K +
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQS-----LMKMK 62
Query: 2338 VENLERELE-IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG------------LE 2384
+ +E LE + + +E A E + K +V L+ ++E QS G LE
Sbjct: 63 AQEVELALEEVEKAGEEQAKFENQ-LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLE 121
Query: 2385 LDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
+ E E++ EL+KE++ +L + N EN + +E ++K+K+ + +
Sbjct: 122 KQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDII 181
Query: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK-----NNYIVL 2499
K+++ + L + + ++ + SQ L + +L+Q LDE + N I +
Sbjct: 182 DYQKQIDSQKETLLSR----RGEDSDYRSQ---LSKKNYELIQYLDEIQTLTEANEKIEV 234
Query: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW-------- 2551
Q+ + + +E+ Q++EK +E +R+K + + ++ +L + +QL
Sbjct: 235 QNQE--MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
Query: 2552 KEQNLELRNLTVELEQKIQ----VLQSKNASLQDTLEVLQSSYKNLEN-ELELTKMDKMS 2606
K +N E + V + K++ +L SK+ + + ++L + + L+N +L+ K + M+
Sbjct: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352
Query: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQ------EELSGEKNRLAGELQLLLE---EI 2657
+ + + ++++++ ++ Q T E++ E+L E R G L + +I
Sbjct: 353 LQQGIQE---RDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKI 409
Query: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
+S+ D LKE T E +++ + D EK+ +E+ E RL + E L
Sbjct: 410 QSTLDILKEKT---KEAERTAELAEADAREKD----KELVEALKRLKDYESGVYGL---- 458
Query: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
+ VEI+ + ++ ++ + EI+ L+ + + +A + + KT +D
Sbjct: 459 -EDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 517
Query: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVD 2837
++ N + ++ + + ++L+K + LEEE+ L+K++ Q+ AQE+ K +
Sbjct: 518 TEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM--AQERGKR-----SATS 570
Query: 2838 ELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
LTTE L E + + + ++ LD L+S + + +A+ E
Sbjct: 571 GLTTEDLNLTENISQGDRISERKLD-----LLSLKNMSEAQSKNE 610
Score = 63.9 bits (154), Expect = 2e-09
Identities = 97/419 (23%), Positives = 179/419 (42%), Gaps = 55/419 (13%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
+ + LE+ + LP R ++++L+ + LKKEK + Q +L + + + K E EKT
Sbjct: 2075 LKFQLEQANKDLP-RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKT 2133
Query: 61 EG------TNLKRENQRL--------MEICESLEKTKQKISHELQVKESQVNFQ-EGQLN 105
G ++REN++L E ++E+ +K+ EL+ ++ + Q
Sbjct: 2134 IGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYE 2193
Query: 106 SGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPS----QYYS- 160
S K EK+ E +R + EL++ AA+ ++ N + T L + Q+
Sbjct: 2194 SKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES 2253
Query: 161 -GSKYEDLKEKYNKEVEERKRLEAEVKALQ---AKK------ASQTLPQATMNHRDIARH 210
G + E K K + + E ++K L+ AKK Q + +AT + + ++
Sbjct: 2254 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKY 2313
Query: 211 QASSSVFSWQQEKTPSHLSSNSQ-RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSS 269
QQ K H+ ++ ++R+ + Q + ++ L I + +AN
Sbjct: 2314 NEDLE----QQIKILKHVPEGAETEQGLKRELQVLRLANHQ-LDKEKAEL-IHQIEANKD 2367
Query: 270 FFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329
S+ DQLK KI +LE +L+ + E Q L+ +++K K EL
Sbjct: 2368 QSGAESTIPDADQLK-------EKIKDLETQLKMSDLEK-------QHLKEEIKKLKKEL 2413
Query: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQK 388
E +E+ Y + K LE+K+KKL+E L + + +A E +
Sbjct: 2414 ---ENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE 2469
Score = 49.7 bits (117), Expect = 5e-05
Identities = 52/240 (21%), Positives = 110/240 (45%), Gaps = 19/240 (7%)
Query: 2657 IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716
I SK ++ EL E E + +H ++ + ++ + E +L L E EK +
Sbjct: 30 ISLSKVEVNELKSEKQE-----NVIHLFRIT-QSLMKMKAQEVELALEEVEKAGEE---- 79
Query: 2717 TNKQYEVEIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
++E +++T KL ++ E S+ + L++ +L L+ + LE+++K
Sbjct: 80 -QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL 138
Query: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDT 2834
K QL NE A+ + L + K+L+++ E L +++ Q + QK T++
Sbjct: 139 EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKE-TLLSR 197
Query: 2835 KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
+ ++ + + L +K E +YLD+ +L ++EK+E + + + + K
Sbjct: 198 RGED-----SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEK 252
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 238 bits (607), Expect = 7e-62
Identities = 501/2579 (19%), Positives = 1052/2579 (40%), Gaps = 454/2579 (17%)
Query: 142 CNTPQKIFTTPLTPSQYYSGSKY-------------EDLKEKYNKEVEERKR------LE 182
C F LT Q+ S +KY E L ++Y KE+ + K+ LE
Sbjct: 306 CTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLE 365
Query: 183 AEVKALQAKKASQTLPQATMNHR-------DIARHQASSSVFSWQQE------------- 222
+A++ + +Q L + + + ++ R +SS + QQE
Sbjct: 366 TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCL 425
Query: 223 ---------------KTPSHLSSNSQRTPIR--RDFSASYFSGEQEVTPSRSTLQIGKRD 265
P+++++ + + I R+ S S + + TL + +
Sbjct: 426 GKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWN 485
Query: 266 ANSSFFDNSSSPHLLDQLKAQN-------QELRNKINELELRLQGHEKEMKGQVNKFQEL 318
+ + + L+ L+A ++LR + E+EL+L+ K +++F+ L
Sbjct: 486 PATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-----KNDLDEFEAL 540
Query: 319 QLQLEK-AKVELI-EKEKVLNKCRDELVRTTAQYDQASTKYTALEQK---LKKLTEDLSC 373
+ + +K +++LI E + N + V ++ S+K L +K +KKL E +
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Q+ S + E K+ ++ L D E + + A+ +++N+
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMKQTL---------FDAETVALDAKRESAFLRSENLE- 650
Query: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS 493
L+ ++ +L + +Q+EN+++ ++ +L A++ Q E EL+ + E+ K +L+
Sbjct: 651 -LKEKMKELATTYKQMENDIQLYQSQL-EAKKKMQVDL--EKELQSAFNEITKLTSLIDG 706
Query: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAE----------EMKAKNTSQETMLRDLQEK 543
+ LE ++ ++++ LN+ E E+K+ + E + +++Q+K
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 544 INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
+++ + +T EK KL + K E ++ L +++ KT+ + S +
Sbjct: 767 -SEELHIITSEKDKLFSEVVHK------------ESRVQGLLEEIGKTKDDLATTQSNYK 813
Query: 604 LKKKEYEELK------EEKTLFSCWKSENEKL---LTQMESEKENLQSKINHLETCL--K 652
+E++ K E+K + ENE++ + + E + S + L+T L K
Sbjct: 814 STDQEFQNFKTLHMDFEQK--YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYK 871
Query: 653 TQQI--KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
TQ++ K+ E ER+ +E +E L L V K++ E + E++ +
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
D Q + E++ ++ QL + D + ++ + ++ R + +++ + LKSK
Sbjct: 932 DDLKQLQ-ESLQIERDQLKSDIHDTVN----MNIDTQEQLRNALESLKQHQETINTLKSK 986
Query: 771 DASLV------------TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
+ V T ++ Q+ ++ D++ + ++ ++ + +
Sbjct: 987 ISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ------TLTADVKDNEI-I 1039
Query: 819 DQSPKNSAILQNRVD---SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE-QMH 874
+Q K +++Q + + LE + ++Q+ +DL++ E + I+ + E L+ E +
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE--MTIENQEELRLLGDELKKQ 1097
Query: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL-KKS 933
Q VA+ K + + S + +AE L+ K ++LQ ++ Q E+ E+ KK
Sbjct: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 934 NHL--LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKM 991
N + L++ LK +L E + E+ E++ ++ N E++ +T+E LKE+ S E+
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217
Query: 992 NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS 1051
+L YI E E + + ++ K + L + E +S+ K AQ N
Sbjct: 1218 HL-------RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE--KTAQIIN- 1267
Query: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL-MLELETVQQAL 1110
T E +L++ + E QE L + E + + LEL T Q
Sbjct: 1268 ---------TQDLEKSHTKLQE-EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT 1317
Query: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
+ T ++ E + L E+ + Q+E+ L +E + L KT E ++
Sbjct: 1318 KDSTT---------LARIEMERLRLNEKFQESQEEIKSLTKERDNL----KTIKEALEVK 1364
Query: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS------------YNAQLVQLEAMLR 1218
+ ++ ++E ++ + K + L +KE ++ ++ L+++E +
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278
+LQES E + + E + DL+ LQ++ E LK+ + K++ E
Sbjct: 1425 GLSKRLQESHDEMKSVAKE----KDDLQ--RLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
L + C L+ +NEL L++ +E T +++
Sbjct: 1479 LKVA-------HCCLKEQEETINELR--------------VNLSEKETEISTIQKQLEAI 1517
Query: 1339 VGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK 1398
KL N+++ + + + + + ++ E+ NE L E + L
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQ-----EKVNE-----LKQFKEHRKAKDSALQSI 1567
Query: 1399 EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQG 1458
E +M EL + Q E +I+ + +M LQ D LK + ++ Q
Sbjct: 1568 ESKM--LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ- 1624
Query: 1459 DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSA 1518
KE Q + + C + L EQ L NLE +
Sbjct: 1625 --EKEYQFLKMTAVNETQEKMCEIEH--------------LKEQFETQKL--NLENIETE 1666
Query: 1519 NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN 1578
N + + + ENL + + + +E +V R L++ + ++ + K
Sbjct: 1667 N------IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720
Query: 1579 KEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL 1638
+E++ + L ++ +D LR +SE +++++ ++E A K Q ++ EL
Sbjct: 1721 EELKIVHMHLKEHQETIDKLR-GIVSEK---TNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 1639 EVARLQLQGLDLSSRSLLGIDTE--DAIQGRNESCDISKEHTSETTERTPKHDVHQICDK 1696
+A + L+ + L GI +E D + + + S E + K + HQ+
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL-KANEHQLI-- 1833
Query: 1697 DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNA 1756
++D+N +K++E +K + + S +S+L
Sbjct: 1834 TLKKDVNETQKKVSEMEQLK--------------------KQIKDQSLTLSKL------- 1866
Query: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV 1816
+I NL L K +ENL E + + MKE D+
Sbjct: 1867 -----------EIENLNLAQK--LHENL-------------EEMKSVMKERDN------- 1893
Query: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
L ++ LK E L E L+ E+ Q ++T+ L+ + + DK
Sbjct: 1894 -----------LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK 1942
Query: 1877 SSRE---------DIGDNVAKVNDSWKERFLDVE-NELSRIR-SEKASIEHEAL----YL 1921
+ DI ++ K D +++ +++ EL +R E ++ H+ + L
Sbjct: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQL 2002
Query: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
+ E + DN K + EE+ +V ER++LR +++ + DQ
Sbjct: 2003 KKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMER---DQFI 2059
Query: 1982 EKMKEK-TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK----THLQEK 2036
++E ++ ++HQ VK + LL ++E L++K L ++
Sbjct: 2060 ATLREMIARDRQNHQ-------------VKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
Query: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL---NVSKAL 2093
++ + L+ +LE +I + KE + VK + SL L EKL N ++
Sbjct: 2107 YSEMDDHYECLNRLSLDLEKEI-EFQKELSMRVKANLSL-PYLQTKHIEKLFTANQRCSM 2164
Query: 2094 E-AALVEKGEFALR-LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS 2151
E +++K ++ L ++ +EE H+ I K + + +KQ + K++ +++ D
Sbjct: 2165 EFHRIMKKLKYVLSYVTKIKEEQHE---SINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
Query: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM---ARSLKVFELDLVTL 2208
++ +L+ M +E++ + S++E ++KT+ +++ + + F + +
Sbjct: 2222 PSRELRDLKLNQNMDLHIEEIL---KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNT 2278
Query: 2209 RSEKENLTKQIQEKQGQLSELDKLLSS-FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267
R + E L IQ++ ++ +++ ++ +++ E + E E S T + + LK
Sbjct: 2279 RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFE----ERSATISKEWEQDLKS 2334
Query: 2268 LNEAVAALCGDQEIMK---ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
L E L + + +K A+ ++P ++ +N RA EK +++L
Sbjct: 2335 LKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN---KNPHVTSRATQLTTEK-----IREL 2386
Query: 2325 KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384
+ S H A + + +E +I + +E LE N + L+AK+ + L +
Sbjct: 2387 ENSLHEA-----KESAMHKESKIIKMQKE---LEVTND--IIAKLQAKVHESNKCLEKTK 2436
Query: 2385 LDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
+ + + +K L + KE+ +++++ E + KE E
Sbjct: 2437 -ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE---------------- 2479
Query: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
KE++ A + +E + +NL + + + + + D +N + +
Sbjct: 2480 ---KEISATKATVEYQKEVIRLLRENLRRSQQA--QDTSVISEHTDPQPSNKPLTCGGGS 2534
Query: 2505 GLIQEVEDGKQKLE--KKDEEISRLKNQ----IQDQEQLVSKLSQVEGEHQLWKEQNLE 2557
G++Q + K E + ++EIS+LK Q I+ + +L+S + E + WKE+ L+
Sbjct: 2535 GIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLK 2593
Score = 232 bits (591), Expect = 5e-60
Identities = 538/2500 (21%), Positives = 1037/2500 (41%), Gaps = 460/2500 (18%)
Query: 901 ETLSALENKEKELQLLN----DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKK 956
ETL+AL+ + N ++V T++A ++ +K L+ L+E+ L + ++EK
Sbjct: 315 ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKD 374
Query: 957 EMSSIIS-------LNKREIEELTQENGTLKEINASLNQE--------------KMNLIQ 995
+++ ++ + +IE LT+ T + +L QE K+N ++
Sbjct: 375 QLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSL--TLQQELKAKRKRRVTWCLGKINKMK 432
Query: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
S NY D+ + + +K + LL+ +E+ + D+ + + S++E
Sbjct: 433 NS----NYADQFNIPTNITTKTHKLS-INLLREIDESVCSESDV---FSNTLDTLSEIEW 484
Query: 1056 LLNECTSLC--ENRKNELEQLK----------EAFAKEHQEFLTKLAFAEERNQNLMLEL 1103
N T L EN ++EL L+ E E +E KL +E+N +L
Sbjct: 485 --NPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL---KEKN-----DL 534
Query: 1104 ETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN---DLLQENEQLMKVM 1160
+ + R D + E LK + + ++ E++ +LL+E E +K +
Sbjct: 535 DEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL 594
Query: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA----- 1215
+ + Q LE+ + S E + K++ ++A+ V L+A
Sbjct: 595 QEYIDSQKLENIKMDLSYSLESIE------------DPKQMKQTLFDAETVALDAKRESA 642
Query: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275
LR++ L+L+E KE +++ +++Q QSQ + K ++D E++ S
Sbjct: 643 FLRSENLELKEKMKELATTYKQME--------NDIQLYQSQ-LEAKKKMQVDLEKELQSA 693
Query: 1276 PHELS--TSQNDNA---HLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
+E++ TS D L C+L ELE LQ E + V E R E I
Sbjct: 694 FNEITKLTSLIDGKVPKDLLCNL--------ELEGKITDLQKELNKEVEENEALREEVIL 745
Query: 1331 AT--RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS--LAPLDE 1386
+ + + EV +L E++ D S LH ++ F E +++ V L + +
Sbjct: 746 LSELKSLPSEVERLRKEIQ---DKSEELH--IITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 1387 SNSYEHLTLSD-KEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKM----SELQTYVDS 1441
+ T S+ K F + + + ++K++ +++ +M+ ++ E Q + S
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860
Query: 1442 LKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLG-DSSFYRALL 1500
L A LS + Q + +E+Q L E + L S+L ++ + + L
Sbjct: 861 LGALKTELSYKTQELQ-EKTREVQERLNE--MEQLKEQLENRDSTLQTVEREKTLITEKL 917
Query: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEE-NLTRKETPSAPAKGVEELESLCEVY 1559
+QT LE + Q D LQE + R + S V E
Sbjct: 918 QQT--------LEEVKTLTQEKDD---LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL 966
Query: 1560 RQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE 1619
R +LE L++ E+ +K+K +E+ + L E + +++QQK+ +
Sbjct: 967 RNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET--------KDEFQQKMVGI--- 1015
Query: 1620 MESKLAAEKKQTEQLSLEL---EVARLQLQGLDL-SSRSLLGIDTEDAIQGRNESCDISK 1675
+ K E K T+ L+ ++ E+ Q + L ++ L E I + + K
Sbjct: 1016 -DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074
Query: 1676 EHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPG 1735
E+ T E + ++ + D+ +Q + EK A+K GE S E
Sbjct: 1075 ENIEMTIEN--QEELRLLGDELKKQQEIVAQEK---NHAIKKEGELSRTCDRLAEVEEKL 1129
Query: 1736 EDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDR 1795
++K+Q E +L L QE++ +Q ++ E N L + +++++
Sbjct: 1130 KEKSQQLQEKQQQL-------------LNVQEEMSEMQKKINEIEN----LKNELKNKEL 1172
Query: 1796 KVESLLNEMKELDSKLH--LQEVQLMTKIEACI-ELEK-----------IVGELKKENSD 1841
+E + E EL KL+ +EV+ +TK + EL+K + E++
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQ 1232
Query: 1842 LSEKLEYFSC---DHQELLQRV------ETSEGLNS-DLEMHADKSSRE--------DIG 1883
E+L+ +HQE + + +T++ +N+ DLE K E ++
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 1884 DNVAKVNDSWK---ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE 1940
NV +V+++ + E L E ++ + A IE E L L + Q E L K+ +
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ---ELESHQSE 1997
N + + LE + + + ++ K + EK E T+ E+E + +
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
+++ E E+ ++ LQ ++ + K+K LQ + L+ +S L K ++
Sbjct: 1413 DSALLRI-EIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL---KENIKEI 1468
Query: 2058 IAQ-LNKEKELLV-----KESES----LQARLSESDYEKLNVSKALEAA----------L 2097
+A+ L E+EL V KE E L+ LSE + E + K LEA +
Sbjct: 1469 VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Query: 2098 VEKGE-FALR-LSSTQEEVHQLRRGIEKLRVR---IEADEKKQLHIAEKLKEREREND-S 2151
EK E F ++ +S QE+V++L++ E + + +++ E K L + +L+E + E
Sbjct: 1529 YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 2152 LKDKVE--------NLERELQMSEENQELVILDAENSKAEVETLKT-----------QIE 2192
+K+K E +ER+ Q+ E +E+V E+ + E + LK +IE
Sbjct: 1589 IKEKEEMKRVQEALQIERD-QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
Query: 2193 EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE 2252
+ + +L+L + +E LT+ + E L +S+ +E++ +++ E
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILHEN----------LEEMRSVTKERD--DLRSVE 1695
Query: 2253 ESKTAVEMLQNQLKE-LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
E+ +++ ++QLKE L E + QE +K L +EHQ +I+KLR +
Sbjct: 1696 ET---LKVERDQLKENLRETITRDLEKQEELKIVHMHL-----KEHQ--ETIDKLRG-IV 1744
Query: 2312 ADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA 2371
+++ ++ +Q K+ EH D LK + ++ EL IA + + + ++ L+
Sbjct: 1745 SEKTNEISNMQ--KDLEHSNDALKAQDLKIQEELRIAH-------MHLKEQQETIDKLRG 1795
Query: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ 2431
+ T L ++ D+ ++ + EL+ + ++ L+ + + + E EQ K Q
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA---KEQNLSSQVECLELEKAQLLQG 2488
+K++S T ++ +++ LN LH + E K+ + NL E L+LE+ QL +
Sbjct: 1856 IKDQSLTLSKL---EIENLN-LAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
Query: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
L E K + +Q + ++ K+ ++K E+IS QI D ++ + K S+ E +
Sbjct: 1912 LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK-SKDELQK 1970
Query: 2549 QLWKEQNLELRNLTV------------ELEQKIQVLQSKNASLQ----DTLEVLQSSYKN 2592
++ + Q EL+ L V E+EQ + +++N S+Q D ++ + +++
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 2593 LEN-ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2651
LE + + D++ +++ KM + + + EM + + ++ EK L+ Q
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKM--ERDQFIATLREMIARDRQ-NHQVKPEKRLLSDGQQ 2087
Query: 2652 LLLEEIKSSKDQLKELTLENSEL--------KKSLDCMHKDQVEKEGKVR---------- 2693
L E ++ ++KEL SE+ + SLD + + +KE +R
Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147
Query: 2694 -----------------------------------------EEIAEYQLR-LHEAEKKHQ 2711
E I ++++ + E EK+ +
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207
Query: 2712 ALLLDTNKQYEVEIQTYREKLTSK---------EECLSS-QKLEIDLLKSSKEELNNSLK 2761
L+ + Q + ++ + RE K EE L + E +K+ +++ ++ K
Sbjct: 2208 LLIKIQHLQQDCDVPS-RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK 2266
Query: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERA-------QGKMKLLIKSCKQLEEEKEILQK 2814
TQ LEE T+ D K N ++KEN+R ++ ++ + EE + K
Sbjct: 2267 EMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK 2326
Query: 2815 ELSQ-LQAAQEK-------------------QKTGTVMDTK-------VDELTTE-IKEL 2846
E Q L++ +EK Q T D K +LTTE I+EL
Sbjct: 2327 EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL 2386
Query: 2847 KETLEEKTKEADEYLDKYCSLLISHEKLEK-----AKEMLETQVAHLCSQQSKQDSRGSP 2901
+ +L E + A + K ++ ++LE AK + ++ C +++K+ +
Sbjct: 2387 ENSLHEAKESA---MHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQ--V 2441
Query: 2902 LLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAV 2961
L V G P E L K ++ +++ +E T AT E + K+ + +
Sbjct: 2442 LQDKVALGAKPYKEEIED-LKMKLVKIDLEKMKNAKEFEKEISATKATVE-YQKEVIRLL 2499
Query: 2962 MSGI---HPAEDT----EGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPR 3014
+ A+DT E T+ +P P G + T IL+ + R
Sbjct: 2500 RENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQ--NTKALILKSEHI--RLEKE 2555
Query: 3015 LAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQR-------------SPVDSGTI 3061
++ K L K L +++ + ++ K + +R SP +GT
Sbjct: 2556 ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTA 2615
Query: 3062 LREP--TTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSP 3099
++ T NL + P +SP+ R + +PSP
Sbjct: 2616 SKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSP 2655
Score = 214 bits (546), Expect = 8e-55
Identities = 429/2172 (19%), Positives = 901/2172 (41%), Gaps = 303/2172 (13%)
Query: 19 KIQELEGQLD--KLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
+I++L+ +D KL+ K + L+S+E Q KQ + + +T + KRE+ L
Sbjct: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ-MKQTLFDAETVALDAKRESAFLRSEN 648
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
L++ ++++ + E+ + + QL + KK LE+EL+ +E+ +
Sbjct: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
CN + K DL+++ NKEVEE + L EV L K+ +
Sbjct: 709 PKDLLCNLELE--------------GKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT--------PIRRDFS---ASY 245
+ ++I + + +++K S + R + D + ++Y
Sbjct: 755 --EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S +QE ++ ++ +N + L + Q+ + + L+ L
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK-- 363
+E++ + + QE ++E+ K +L ++ L E T + Q + L Q+
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
Query: 364 -LKKLTEDLSCQRQNAES---ARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
LK+L E L +R +S ++ +E+ + E L + Q + TL K+
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL-------KS 985
Query: 420 RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRR 479
++++E+ ++N+H +++ +EF+QK+ + K+ +L
Sbjct: 986 KISEEV--SRNLH------------MEENTGETKDEFQQKMVGID--------KKQDL-- 1021
Query: 480 SMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
E K L ++ K E+ + ++ ++ Q N+ Q E + A+ +E + D
Sbjct: 1022 ---EAKNTQTLT---ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE---KEQLKTD 1072
Query: 540 LQEKINQQ-ENSLTLEKLKLAVADLEKQRDC---SQDLLKKREHHIEQLNDKLSKTEKES 595
L+E I EN E+L+L +L+KQ++ ++ K+E + + D+L++ E++
Sbjct: 1073 LKENIEMTIENQ---EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
Query: 596 KALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK---INHLETCLK 652
K L+ K+++ ++EE SE +K + ++E+ K L++K + H+ET
Sbjct: 1130 KEKSQQLQEKQQQLLNVQEE-------MSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 653 TQQIKSHEYNERVRTLEMDR---ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
K +E E V+++ +R + L + L E+E L E + A
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
Query: 710 SDQKHQKEIENMCLKTSQLTGQV---EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL 766
++HQ+ I+ + S+ T Q+ +DLE L EI LH E E L ++
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-------PVLHEEQELLPNV 1295
Query: 767 LKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSA 826
+ + NE ++ EQ + + R+E ++ N
Sbjct: 1296 KEVSETQETMNE-------------------LELLTEQSTTKDSTTLARIEMERLRLNEK 1336
Query: 827 I--LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Q + SL ++ K + L+ + + Q+K I E L K ++ ++ Q
Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHD---QLKEHIRETLAKIQESQ----SKQEQS 1389
Query: 885 ISKLQEDTSAHQNVVAETLSALEN-KEKELQLLNDKVETEQAEI-QELKKSNHLLEDSLK 942
++ ++D N + +S +E K K+ LL ++E E + + L++S+ ++ K
Sbjct: 1390 LNMKEKD-----NETTKIVSEMEQFKPKDSALL--RIEIEMLGLSKRLQESHDEMKSVAK 1442
Query: 943 E---LQLLSETLSLE----KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
E LQ L E L E K+ + I++ + EEL + LKE ++N+ ++NL +
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502
Query: 996 KSESFANYIDERE----KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS 1051
K + + E K +++ + Y++E+ +++ E +L Q + + K+S
Sbjct: 1503 KETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDS 1562
Query: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEF-LTKLAFAEERNQ----------NLM 1100
L+ + ++ L NR E ++ + KE +E + A ER+Q +
Sbjct: 1563 ALQSIESKMLEL-TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK 1621
Query: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE---VNDLLQEN-EQL 1156
E Q L+ + E LK++ T K ++ E + +L EN E++
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM 1681
Query: 1157 MKVMKTKHECQNLES--EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLE 1214
V K + + +++E + R+ +KE E + + Q +L++ + L + + +L
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741
Query: 1215 AMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274
++ K ++ +K+ L+H ++ QD++ QE + + +++ I
Sbjct: 1742 GIVSEKTNEISNMQKD---LEHSNDALKA-------QDLKIQEELRIAHMHLKEQQETID 1791
Query: 1275 GPHELSTSQNDN-AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATR 1333
+ + + D +++Q L+ + KL EKI E L+A +++L+T D + T+
Sbjct: 1792 KLRGIVSEKTDKLSNMQKDLENSNAKLQ--EKIQE-LKANEHQLITLKKD-----VNETQ 1843
Query: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH- 1392
K E+ +L ++K D S L +E++ + + E+ + D E
Sbjct: 1844 KKVSEMEQLKKQIK---DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900
Query: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN 1452
L L +++ E + + L +Q E K +M SK E + VD L+ + +
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKT-----ARMLSK--EHKETVDKLREKISEKTIQ 1953
Query: 1453 LRNFQGDLVK---EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLL 1509
+ + Q DL K E+Q ++E L V + ++S + +EQ
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE-----MEQLKKQFEA 2008
Query: 1510 SNLE-GAVSANQCSVDEVFCSSLQEENLTRKE-------TPSAPAKGVEELESLCEVYRQ 1561
NL +V + + + SL+E + KE S + + + +L E+ +
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR 2068
Query: 1562 SLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEME 1621
+ + K E + + + Q L + L + + L K+Y SE + + L ++L++E
Sbjct: 2069 DRQNHQVKPEKRLLSDGQ--QHLTESLREKCSRIKELLKRY-SEMDDHYECLNRLSLDLE 2125
Query: 1622 SKLAAEKKQTEQLSLELEVARLQLQGLD--LSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679
++ +K+ + ++ L + LQ + ++ ++ ++ ++ +
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 1680 ETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAV--KPTGECSGEQSPDTNYEPPGED 1737
E E K ++ I + + Q++L + I+ + + V + + Q+ D + E +D
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2245
Query: 1738 KTQG-----SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIED 1792
++ +E LS ++L + DI L+ +++ EN R+ V
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK---ENDRICQVNNF 2302
Query: 1793 RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCD 1852
+ ++ +++NE E + + E E+ + LK++N L +
Sbjct: 2303 FNNRIIAIMNESTEFEER----------SATISKEWEQDLKSLKEKNEKLFKN------- 2345
Query: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
Q ++TS + + + + ++ E+ ++EN L +
Sbjct: 2346 ----YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLT---TEKIRELENSLHEAKESAM 2398
Query: 1913 SIEHEALYLEADLEV-----------VQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961
E + + ++ +LEV V CLEK E I L++++++
Sbjct: 2399 HKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE----TIQVLQDKVALGAKPYK 2454
Query: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021
+ E++ + K +D EKMK +E E I +A V+ + E+++ L
Sbjct: 2455 E---EIEDLKMKLVKID--LEKMK-NAKEFEKE-------ISATKATVEYQKEVIRLLRE 2501
Query: 2022 DV--SELLKDKTHLQEKL--------------QSLEKDSQALSLTK--CELENQIAQLNK 2063
++ S+ +D + + E + ++++AL L LE +I++L +
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561
Query: 2064 EKELLVKESESL 2075
+ E L+K+ L
Sbjct: 2562 QNEQLIKQKNEL 2573
Score = 162 bits (410), Expect = 5e-39
Identities = 288/1446 (19%), Positives = 585/1446 (40%), Gaps = 221/1446 (15%)
Query: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNL 65
KEG +R ++ E+E +L + ++ Q++Q QL +++ + +QK+ ++EN K E N
Sbjct: 1111 KEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK 1170
Query: 66 K-----RENQRL---MEICESLEKTKQKISHELQVKESQVNF--QEGQLNSGKKQIE--- 112
+ E +RL ++ E+ E+ K +KE Q +F + L ++IE
Sbjct: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 113 -KLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171
+ ++ELK L+ Q+ S++ T Q I T +DL++ +
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSE-KTAQIINT--------------QDLEKSH 1275
Query: 172 NKEVEERKRLEAEVKAL-QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSS 230
K EE L E + L K+ S+T Q TMN ++ Q+++ S+
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSET--QETMNELELLTEQSTTKD------------ST 1321
Query: 231 NSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL 290
R + R F QE S + +RD + + H DQLK +E
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTK----ERDNLKTIKEALEVKH--DQLKEHIRET 1375
Query: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAK----------VELIEKEKVLNKCR 340
KI E + + Q MK + N+ ++ ++E+ K +E++ K L +
Sbjct: 1376 LAKIQESQSK-QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLS-------CQRQNAESARCSLEQKIKEKE 393
DE+ + D L+ + +L E++ + + A C L+++ +E
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ-EETI 1493
Query: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
E + LS ++ T+ ++ + +L ++Q+ Q + +++ V++++ N L
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE--QFNIKQISEVQEKV-NEL 1550
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ--KAREVCHLEAE--L 509
++FK+ + A Q+ + K EL ++E ++E ++ E+ + +E +E +
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
Query: 510 KNIKQCLNQSQNFAE------EMKAKNTSQETM--LRDLQEKINQQENSL---------- 551
+N K+ + + + E +M A N +QE M + L+E+ Q+ +L
Sbjct: 1611 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1670
Query: 552 ------TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
LE+++ + + R + L +R+ E L + +++ + E + L + +
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR-DLEKQEELKIVHMH 1729
Query: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV 665
KE++E ++ ++++ +E N+Q + H LK Q +K E +
Sbjct: 1730 LKEHQETIDKL----------RGIVSEKTNEISNMQKDLEHSNDALKAQDLK---IQEEL 1776
Query: 666 RTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKT 725
R M + I L ++ K T KL+ M QK++EN K
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEK-----TDKLSNM-------------QKDLENSNAKL 1818
Query: 726 SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLL 785
+ +++ EH+L L ++ + Q +E E L+ +K + +L E +L
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNET----QKKVSEMEQLKKQIKDQSLTLSKLEIENLNL- 1873
Query: 786 AFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845
+H + + E S+ ER R + L+ D L+ SL+ K
Sbjct: 1874 ----AQKLHEN----LEEMKSVMKERDNLR-------RVEETLKLERDQLKESLQETKAR 1918
Query: 846 NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA 905
+ ++Q++ + + E +E + K + ++E + +IS +Q+D ++ + + +
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREK----ISEKTIQISDIQKDLDKSKDELQKKIQE 1974
Query: 906 LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
L+ KE +L + + V +I E+++ L+ + L +++ ++ +++ + +
Sbjct: 1975 LQKKELQLLRVKEDVNMSHKKINEMEQ----LKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 966 KREIEELTQENGTLKEINASLNQEKMNLIQK-----SESFANYIDEREKSISELSDQYKQ 1020
EI + +E L+ I SL E+ I + N+ + EK + Q+
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 1021 EKL--------ILLQRCEETGNAYE-------DLSQKYKAAQEKNSKLECLLNECTSLCE 1065
E L LL+R E + YE DL ++ + +E + +++ L SL
Sbjct: 2091 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL----SLPY 2146
Query: 1066 NRKNELEQLKEAFAKEHQEF---LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
+ +E+L A + EF + KL + + E + D K
Sbjct: 2147 LQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQK 2206
Query: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
L +I L+++ + +E+ DL + + + + E I+ ++
Sbjct: 2207 E----LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
Query: 1183 SERNQCN------FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH 1236
S R + + D+E + + N ++ Q+ N+ + + E +
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE---FEE 2319
Query: 1237 ELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTT 1296
TI + E Q++ LK + EK L TS A Q + T
Sbjct: 2320 RSATISKEWE---------QDLKSLK----EKNEKLFKNYQTLKTSLASGA--QVNPTTQ 2364
Query: 1297 MNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL 1356
NK + L EK + EL +S E + ++ K+ E+++ ND L
Sbjct: 2365 DNKNPHVTSRATQLTTEK---IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
Query: 1357 HGELVE 1362
++ E
Sbjct: 2422 QAKVHE 2427
Score = 134 bits (338), Expect = 1e-30
Identities = 238/1196 (19%), Positives = 510/1196 (42%), Gaps = 188/1196 (15%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + + ++QE +L + K+ ++ + L S+E+ + + +++ + E +
Sbjct: 1530 EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK--KQIEKLEQELKRCKSE 124
+E + + + E+L+ + ++ KE +E Q + K E + K C E
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKE--NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC--E 1645
Query: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE--KYNKEVEERKRLE 182
+E ++ ++ ++L T T L +E+L+E KE ++ + +E
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQIL----------HENLEEMRSVTKERDDLRSVE 1695
Query: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
+K ++ + + L + RD+ + + V HL + + R
Sbjct: 1696 ETLK-VERDQLKENLRETIT--RDLEKQEELKIVH--------MHLKEHQETIDKLRGIV 1744
Query: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ 302
+ E T S +Q H D LKAQ+ +++ ++ + L+
Sbjct: 1745 S-------EKTNEISNMQ-------------KDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
Query: 303 GHEK---EMKG----QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAST 355
++ +++G + +K +Q LE + +L EK + L +L+ ++
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK 1844
Query: 356 KYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQ 412
K + +EQ LKK +D S E +L QK+ E +E + +E +R +TL
Sbjct: 1845 KVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI 472
E Q+K + LQ+ K +Q EL + ++ + +++ ++K+ +E+ Q S I
Sbjct: 1904 ERDQLK----ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI--SEKTIQISDI 1957
Query: 473 KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
+ +L +S +E++K+ L ++K ++ ++ ++ + +N+ + ++ +A+N S
Sbjct: 1958 -QKDLDKSKDELQKKIQEL----QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012
Query: 533 QETMLRD---LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
+++ D L +K+++ +LE++++ + ++ R + L +R+ I L + ++
Sbjct: 2013 MQSVRMDNFQLTKKLHE-----SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIA 2067
Query: 590 KTE-----KESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
+ K K LLS + ++ E L+E K K L + SE ++ +
Sbjct: 2068 RDRQNHQVKPEKRLLS--DGQQHLTESLRE--------KCSRIKELLKRYSEMDDHYECL 2117
Query: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSV------EIRNLHNVLDSKSVEVE--TQ 696
N L L+ + E + RV+ NLS+ I L S+E +
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKA------NLSLPYLQTKHIEKLFTANQRCSMEFHRIMK 2171
Query: 697 KLAYM-----ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-KD 750
KL Y+ +++++ S K + + + K +L +++ L+ + S E+ D K
Sbjct: 2172 KLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKL 2231
Query: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
DLH E E L+D +S+ S+ T + Q+ L + M + + +
Sbjct: 2232 NQNMDLHIE-EILKDFSESEFPSIKT--EFQQVL---SNRKEMTQFLEEWLNTRFDIEKL 2285
Query: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
++ + E D+ + + NR+ ++ ++ ++ + K+ E+ ++ E E L K
Sbjct: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345
Query: 871 EQMHQSFVAETSQRISKLQEDTSAH-----QNVVAETLSALENK---------------- 909
Q ++ +A +Q Q++ + H + E + LEN
Sbjct: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Query: 910 --EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR 967
+KEL++ ND + QA++ E SN LE + + +Q+L + ++L K K
Sbjct: 2406 KMQKELEVTNDIIAKLQAKVHE---SNKCLEKTKETIQVLQDKVALGAKPY-------KE 2455
Query: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
EIE+ LK ++ EKM + ++ F E+E S ++ + +Y++E + LL+
Sbjct: 2456 EIED-------LKMKLVKIDLEKM---KNAKEF-----EKEISATKATVEYQKEVIRLLR 2500
Query: 1028 RCEETGNAYEDLS--QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+D S ++ Q N L C + + +N K + EH
Sbjct: 2501 ENLRRSQQAQDTSVISEHTDPQPSNKPLTC--GGGSGIVQNTKALI------LKSEHIRL 2552
Query: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
+++ +++N+ L+ + ++E+ N + +E K+ TLK E +K
Sbjct: 2553 EKEISKLKQQNEQLIKQ--------KNELLSNNQHLSNEVKTWKER--TLKREAHK 2598
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 211 bits (536), Expect = 1e-53
Identities = 296/1320 (22%), Positives = 568/1320 (43%), Gaps = 175/1320 (13%)
Query: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHT 1678
++++ L EK +E+L ELE + QGL G+ T+ S ++
Sbjct: 94 DLQASLKEEKWYSEELKKELE----KYQGLQQQEAKPDGLVTDS-------SAELQSLEQ 142
Query: 1679 SETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDK 1738
+T ++ Q+ D Q+ L TE +K + + + E K
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQL----ATEIADIK------SKYDEERSLREAAEQK 192
Query: 1739 TQGSSECISELSFSGPNALVPMDF---LGNQEDIHNLQLRVKETSNENLRLLHVIEDRDR 1795
+E +++ A V D L + I ++ + KE + ++ +R+R
Sbjct: 193 VTRLTEELNK------EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 1796 KVESLLNEMKELDSKLHLQEV---QLMTKI-EACIELEKIVGELKKENSDLSEKLEYFSC 1851
+ E L +E K+L S+ E QL +++ + E+ V EL+K S ++E +
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ---- 302
Query: 1852 DHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEK 1911
+Q L + + E + LE +K + E + + + ++ LD + SR+ + +
Sbjct: 303 KNQTLTENLLKKEQDYTKLE---EKHNEESVSKK--NIQATLHQKDLDCQQLQSRLSASE 357
Query: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971
S+ +++E L + E QK L+EELS V ++ L+ E +
Sbjct: 358 TSLHR--IHVE------------LSEKGEATQK----LKEELSEVETKYQHLKAEFKQLQ 399
Query: 1972 KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT 2031
++ +Q +++ + +L S E + A +KE+ +L D + + D
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD-- 457
Query: 2032 HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSK 2091
LQ KL LE+ + EL++Q+ + ++ + +S A+L E+ + V +
Sbjct: 458 -LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 2092 ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS 2151
+ + L ++E + L + E L +I+A E + L + + +N +
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE----TAVLNQLQEKNHT 572
Query: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE 2211
L+++V L +L+ NQ +E+ K E L Q++E L+ + +++L +
Sbjct: 573 LQEQVTQLTEKLK----NQ------SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI----QIKEESKTAVEMLQNQLKE 2267
L Q+ E + ++S+LD + + LL E A+ ++ TA LQ++ +E
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 2268 LN-------EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCV 2320
LN + A L QE E L E+ L E+L +++ E L V
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 2321 -------LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
LQ L++ L+ R L ++LE+ + L+ + +E++K K+
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQEKVQM 2432
+ + L+ D T+ E + EL Q ++EL+ + E ++ E K ++
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
+ S + KE + AA+ + ++ CK + L Q+E E+ +L + L++
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI----QDQEQLVSKLSQVEGEH 2548
K L+ +N + +++ + L++ ++E +L+ I Q EQ ++ ++GE
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Query: 2549 QLWKEQNLELRN-LTVELEQ----------KIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
++ Q EL N L +L Q KI VLQ+ Q+T + LQS + E+EL
Sbjct: 983 KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Query: 2598 ELTKMDKMSFVEKV-----------------NKM-----TAKET------ELQREMHEMA 2629
T+ D S EK+ NK+ TAK T + ++++ E
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 2630 QKTAELQEELSGEKNRLAGELQLL--LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVE 2687
+ ++Q+E S ++ L E L +EEIK ++ KE+T N ELK HK +
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE--KEITKLNEELKS-----HKLESI 1155
Query: 2688 KE----GKVREEIAEYQLRLH----------EAEKKHQALLLDTNKQYEVEIQTYREKLT 2733
KE ++ + + +L L E EK++Q +L D K+ E E+ +++
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL---KKEFI 1212
Query: 2734 SKEECLSSQKLEIDLLKSSKEELNNSLKATTQI------LEELKKTKMDNLKYVNQLKKE 2787
KE L S+ E ++ EE N K T QI L +KK + + V++L+K+
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEE--NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
Query: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV-MDTKVDELTTEIKEL 2846
+ +G++ +L + + ++E+ L + + + EK +T + + K+D T ++EL
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Score = 192 bits (487), Expect = 6e-48
Identities = 272/1147 (23%), Positives = 503/1147 (43%), Gaps = 175/1147 (15%)
Query: 1804 MKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETS 1863
+K D L QEVQ +L+ + E K + +L ++LE + Q L Q+
Sbjct: 80 LKRDDVTLLRQEVQ---------DLQASLKEEKWYSEELKKELEKY----QGLQQQEAKP 126
Query: 1864 EGLNSD-------LEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEH 1916
+GL +D LE +++ E+ N+ ++ D ++++ + E++ I+S+ E
Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENF--NIKQMKDLFEQKAAQLATEIADIKSKYD--EE 182
Query: 1917 EALYLEADLEVVQ-TEKLCLEKDNENKQKVIVCLE---EELSVVTSERNQLRGELDTMSK 1972
+L A+ +V + TE+L E K + E+++V+ E Q++ +D M
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM-- 240
Query: 1973 KTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032
T ++ SEK+K++ ++L+S Q A +E T+S SEL K
Sbjct: 241 -TLERERESEKLKDECKKLQS---------QYASSEA--------TISQLRSELAKGPQE 282
Query: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKE--KELLVKESE--SLQARLSESDYEKLN 2088
+ +Q L+K ++ N++ Q N+ + LL KE + L+ + +E K N
Sbjct: 283 VAVYVQELQKLKSSV--------NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKN 334
Query: 2089 VSKALEAALVEKGEFALRLSSTQEEVHQLR-------RGIEKLRVRIEADEKKQLHIAEK 2141
+ L ++ + RLS+++ +H++ +KL+ + E K H+ +
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 2142 LKERERENDSLKDKVENLERELQMSEENQEL--VILDAENSKAEVE-TLKTQIEEMARSL 2198
K+ +++ + E + LQ+ E +L +L+ E E LK Q + + L
Sbjct: 395 FKQLQQQRE------EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
Query: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258
E + L+ + L +Q++EK +EL L K +E++ + + + A
Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
Query: 2259 EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL 2318
L+ L+++ + DQ+I E L E L E L A+++A E +
Sbjct: 509 NDLEQVLRQIGDK------DQKIQNL-EALLQKSKENISLLEKEREDLYAKIQAGEG-ET 560
Query: 2319 CVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQ 2378
VL QL+E H L+ +V L +L+ NQ +E+ K E L +++
Sbjct: 561 AVLNQLQEKNH---TLQEQVTQLTEKLK----NQ------SESHKQAQENLHDQVQEQKA 607
Query: 2379 SLRGLELDVVTIRSEKENLTNELQKEQERISELEI-INSSFENILQE---KEQEKVQMKE 2434
LR + V+++ + L ++L + +E++S+L+I I + E +L K ++ ++
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
TA LQ + +ELN+ L DQ K +++ Q C +LE L E K
Sbjct: 668 HLDTAQNALQDKQQELNKITTQL--DQVTAKLQDK----QEHCSQLESH-----LKEYKE 716
Query: 2495 NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ-IQDQEQLVSKLSQVEGEHQLWKE 2553
Y+ L+ +E+E +KLE E+ K Q +QD +Q + QL +
Sbjct: 717 KYLSLEQKT----EELEGQIKKLEADSLEVKASKEQALQDLQQ----------QRQLNTD 762
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
L L+ +LE + +++ S LQ E L+S + L + E ++ K F +
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF-----E 817
Query: 2614 MTAKETELQRE-MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK----ELT 2668
++ET++Q E ++ Q T +++ EK L EL + +++ D LK E
Sbjct: 818 TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 2669 LENSELKKSL--------DCMHKDQVEKEGKVREEI-----------AEYQLRLHEAEKK 2709
EN + K ++ + H+ QV+ E ++E+ A +QL+L +
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 2710 HQALLL-DTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS-------KEELNNSLK 2761
Q + +T KQ E E Q + + ++ +K +I+ L+ K EL N L+
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 2762 AT-TQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELS--- 2817
TQ +EL K + ++ L+ E++Q K L E E +++L
Sbjct: 998 QQLTQAAQELAAEK----EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
Query: 2818 -QLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLL--ISHEKL 2874
+L AQE + ++L E+K K TLE+ + + ++ L + C L I EK
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 2875 EKAKEML 2881
K KE++
Sbjct: 1114 LKEKELV 1120
Score = 181 bits (458), Expect = 1e-44
Identities = 281/1372 (20%), Positives = 566/1372 (41%), Gaps = 201/1372 (14%)
Query: 18 QKIQELEGQL-------DKLKKEK------QQRQFQLDSL----EAALQKQKQKVENEKT 60
Q++Q+L+ L ++LKKE QQ++ + D L A LQ +Q++E +T
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 61 EGTNLKRE----NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQ 116
E N+K+ Q+ ++ + K K E ++E+ EQ
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA------------------AEQ 191
Query: 117 ELKRCKSELERSQQAAQSADVSL--NPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKE 174
++ R EL + Q L P + L + + L + E
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV--------QVQTLMDNMTLE 243
Query: 175 VE-ERKRLEAEVKALQAKKASQTLPQATMN--HRDIARHQASSSVFSWQQEKTPSHLSSN 231
E E ++L+ E K LQ++ AS +AT++ ++A+ +V+ + +K S ++
Sbjct: 244 RERESEKLKDECKKLQSQYASS---EATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
+Q+ + + + EQ+ T K + +
Sbjct: 301 TQK---NQTLTENLLKKEQDYT------------------------------KLEEKHNE 327
Query: 292 NKINELELRLQGHEKEMKGQ--VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
+++ ++ H+K++ Q ++ + L + VEL EK + K ++EL
Sbjct: 328 ESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL------ 381
Query: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT 409
+ TKY L+ + K+L + QR+ E L+ +I + + E + +
Sbjct: 382 -SEVETKYQHLKAEFKQLQQ----QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436
Query: 410 LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
L ++ +L + QQ + LQ +L +L ++ N E + +L + +Q Q
Sbjct: 437 LKEQRQLSSEKLMDKEQQVAD----LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 470 SQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Q + + E + + + K +++ +LEA L+ K+ ++ + E++ AK
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
Query: 530 ---NTSQETMLRDLQEK---INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583
+ +L LQEK + +Q LT EKLK ++ ++ D +++++ H+
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLT-EKLKNQSESHKQAQENLHDQVQEQKAHLRA 611
Query: 584 LNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
D++ E L S L K++ +L + K++ E LL+ ++
Sbjct: 612 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQ------IKAKTELLLSAEAAKTAQRADL 665
Query: 644 INHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH-NVLDSKSVEVETQKLAYME 702
NHL+T Q K E N+ T ++D+ ++ + H + L+S ++ K Y+
Sbjct: 666 QNHLDTAQNALQDKQQELNK--ITTQLDQVTAKLQDKQEHCSQLES---HLKEYKEKYLS 720
Query: 703 LQQKA-EFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE 761
L+QK E Q + E +++ +K S+ ++DL+ + QL ++ + + L E E
Sbjct: 721 LEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
Query: 762 SLR----DLLKSKDA-----SLVTNEDHQRSLLAFD----------QQPAMHHSFANIIG 802
+ DL K +A +T ++ ++ +L D Q +++ +
Sbjct: 780 IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 803 EQGSMPSER----SECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV- 857
E + E+ +E D+ K S L+N E + K DL+K C+EL
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917
Q++ ++E L + +++ +S E + +L+ + ++ Q + + + L+ EKE Q L
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL- 957
Query: 918 DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
Q I ELK+S+ E K+++ L L I L K E+E Q+
Sbjct: 958 ------QGNINELKQSS---EQKKKQIEALQGEL--------KIAVLQKTELENKLQQQL 1000
Query: 978 TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC------EE 1031
T + +EK++++Q NY +E SD Y +E +L R E+
Sbjct: 1001 TQAAQELAAEKEKISVLQN-----NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
A EDL +N ++ L +L ++ + +QL+E K Q+ + +
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER-CKALQDIQKEKSL 1114
Query: 1092 AEE---RNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND 1148
E+ ++ + E+E ++ E+T KS +EI LK+ + + ++ +
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 1149 LLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY-- 1206
L + + L ++ + Q + + ++ +E + E + K +++ KE+ + +
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 1207 -----NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLET--SNLQDMQSQEIS 1259
Q+ L L + + Q S++ L+ + +RG++ + +Q+ Q + +
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRA 1294
Query: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
L+ C + G E+ Q LQ L T + EL + + LQ
Sbjct: 1295 LLERC--------LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 168 bits (425), Expect = 9e-41
Identities = 289/1451 (19%), Positives = 579/1451 (39%), Gaps = 226/1451 (15%)
Query: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK 1161
EL +A+ D+ + +S + ++ L++E +Q + + +E+L K ++
Sbjct: 55 ELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE 114
Query: 1162 TKHECQNLESEP---IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218
Q E++P + +S E +S Q + +K++ D + + QL +
Sbjct: 115 KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK-DLFEQKAAQLATEIA 173
Query: 1219 NKELKLQESEKEKECLQHELQTIRGDL--ETSNLQDMQSQEIS--GLKDCEIDAEEKYIS 1274
+ + K E +E + ++ + +L E + +QD++++ + G++D + +E
Sbjct: 174 DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV-- 231
Query: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKI---CEILQAEKYELVTELNDSRSECITA 1331
++ T ++ T+ + E EK+ C+ LQ++ ++ RSE
Sbjct: 232 ---QVQTLMDN---------MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG 279
Query: 1332 TRKMA---EEVGKLLNEVKILNDDSGLLHGELV---------EDIPGGEFGEQPNEQHPV 1379
+++A +E+ KL + V L + L L+ E+ E + N Q +
Sbjct: 280 PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339
Query: 1380 SLAPLDESNSYEHLTLSDKEVQMHFAELQEK---FLSLQSEHKILHDQHCQMSSKMSELQ 1436
LD L+ S+ + EL EK L+ E + ++ + ++ +LQ
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVK-EMQLGLEEGLVPS---LSSSCVPDSSSLSSLGD 1492
+ + L L + + L++ E QLG G + LSS + D
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE------- 452
Query: 1493 SSFYRALLEQTGDMSL-LSNLEGAVS---ANQCSVDEVFCSSLQEENLTRKETPSAPAKG 1548
+Q D+ L LS LE + N + + Q+ + S AK
Sbjct: 453 --------QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 1549 VEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL----------DCL 1598
E L +V RQ +K ++K+++ + K + + LL ER++L +
Sbjct: 505 REAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENIS-LLEKEREDLYAKIQAGEGETAV 562
Query: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658
Q +N Q+++T +T +++++ + K+ E L +++ + L+
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA----------- 611
Query: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPT 1718
+D + S + +E+ E+ + D+ + E + A K
Sbjct: 612 -AQDRVLSLETSVNELNSQLNESKEKVSQLDIQ----------IKAKTELLLSAEAAKTA 660
Query: 1719 GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKE 1778
+ DT NAL Q++++ + ++ +
Sbjct: 661 QRADLQNHLDT-----------------------AQNALQD-----KQQELNKITTQLDQ 692
Query: 1779 TSNENLRLLHVIEDRDRKVESLLNEMKELDSK-LHLQEVQLMTKIEACIELEKIVGELKK 1837
+ + ++D+ L + +KE K L L++ + E++ G++KK
Sbjct: 693 VTAK-------LQDKQEHCSQLESHLKEYKEKYLSLEQ-----------KTEELEGQIKK 734
Query: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF 1897
+D E ++ LQ ++ LN+DLE+ A + S++ + +
Sbjct: 735 LEADSLE----VKASKEQALQDLQQQRQLNTDLELRATELSKQ-----LEMEKEIVSSTR 785
Query: 1898 LDVENELSRIRSEKASI---EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954
LD++ + + S K + E E L+ D E + E ++ N+ + V EL
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT---ELQ 842
Query: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014
V E+ L EL T+ K L ++S+ +K E E + I E KE
Sbjct: 843 KVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074
LQ + LK++ L++ L+ ++ S L L ++ Q+ Q + KE +
Sbjct: 900 QLQV---QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134
LQ ++E K +EA +GE L+++ Q + E + K
Sbjct: 957 LQGNINELKQSSEQKKKQIEAL---QGE--LKIAVLQ---------------KTELENKL 996
Query: 2135 QLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Q + + +E E K+K+ L+ + S+E + + D ++E+ + ++ +
Sbjct: 997 QQQLTQAAQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEES 2254
L + + DL++ R++ N K IQE + + L++ + + L+E+ +A I++E
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 2255 KTAVEMLQNQLKELNEAVAALC-GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313
+ L N+ +L E C ++EI K E+ + H+L E ++
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL------KSHKL----ESIKEITNLK 1162
Query: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR--TNQEHAALEAENSKGEVE---T 2368
+ KQL + Q+L E + AD LK VE +R +I + +E L+ E + E +
Sbjct: 1163 DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221
Query: 2369 LKAKIEGM---TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS-------F 2418
+K K GM ++ L + + + + E Q Q R+SELE
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
Query: 2419 ENILQEKEQEKVQMKE---KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
E +Q + E+ + E K +E LQT++ EL ++ + A Q L +
Sbjct: 1282 EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL-------DNTTAAVQELGREN 1334
Query: 2476 ECLELEKAQLL 2486
+ L+++ Q L
Sbjct: 1335 QSLQIKHTQAL 1345
Score = 164 bits (414), Expect = 2e-39
Identities = 225/1010 (22%), Positives = 440/1010 (43%), Gaps = 136/1010 (13%)
Query: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE- 2008
E L++ + LR E+ + SE++K+ ELE +Q +Q EA+
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKK---ELEKYQG-----LQQQEAKP 126
Query: 2009 ---VKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
V + + LQ+L + E + ++++ E+ + L+ +++++ E+
Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY----DEE 182
Query: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
L + +E RL+E ++ V + L+ L++ R GIE +
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ------------------RPGIEDVA 224
Query: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN------------QELV 2173
V + + Q + ERERE++ LKD+ + L+ + SE QE+
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284
Query: 2174 IL--DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
+ + + K+ V L + + + +L E D L + + + Q L + D
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344
Query: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
+S L E + +I E E Q +EL+E + K +Q +
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 2292 PIEEEHQLRNSIEKLRARL------------EADEKKQLCVLQQLKESEHHADLLKGRVE 2339
+ QL++ I +L ++L E++QL + + + + ADL + ++
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL-QLKLS 463
Query: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399
LE +L+ TN + + +K + + +A + T LR + D+ E +
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL-------EQVLR 516
Query: 2400 ELQKEQERISELE-IINSSFENI-LQEKEQE----KVQMKEKSSTAMEMLQTQLKELNER 2453
++ + ++I LE ++ S ENI L EKE+E K+Q E + + LQ + L E+
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 2454 VAAL----HNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509
V L N E+ K ++NL QV+ +KA L A++ + L++SVN L +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQ---EQKAHLRA----AQDRVLSLETSVNELNSQ 629
Query: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL------ELRNLTV 2563
+ + K+K+ + D +I + K ++ + + + ++ L QN EL +T
Sbjct: 630 LNESKEKVSQLDIQI-KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 2564 ELEQKIQVLQSKN---ASLQDTLEVLQSSYKNLENELE-----LTKMDKMSFVEKVNKMT 2615
+L+Q LQ K + L+ L+ + Y +LE + E + K++ S K +K
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 2616 A-KETELQREMH-EMAQKTAELQEELSGEKNRLAG---ELQLLLEEIKSSKDQLKELTLE 2670
A ++ + QR+++ ++ + EL ++L EK ++ +LQ E ++S K +L + E
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
LK+ + + ++ + ++ I L + + + +AL+ E+ T ++
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM--------TELSTVKD 860
Query: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE- 2789
KL+ D LK+SK E + + +L+KT + LK+ Q++ EN
Sbjct: 861 KLSKVS----------DSLKNSKSEFEKENQKGKAAILDLEKTCKE-LKHQLQVQMENTL 909
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK----QKTGTVMDTKVDELTTEIKE 2845
+ Q ++K K LE+EKE + +L + QE+ Q T + + +L I E
Sbjct: 910 KEQKELK------KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 2846 LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVA-HLCSQQSK 2894
LK++ E+K K+ + + ++ +LE + TQ A L +++ K
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Score = 164 bits (414), Expect = 2e-39
Identities = 252/1102 (22%), Positives = 466/1102 (42%), Gaps = 161/1102 (14%)
Query: 1561 QSLEKLEEKMESQGIMKNK----------EIQELEQLLSSERQELDCLRKQYLSENEQWQ 1610
Q KLEEK + + K + Q+L+ LS+ L + + LSE +
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-LSEKGEAT 374
Query: 1611 QKLTSVTLEMESK---LAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGR 1667
QKL E+E+K L AE KQ +Q E E LQLQ S L ++TE +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL-LETERQL--- 430
Query: 1668 NESCDISKEHTSETTERTPKHDVHQICDKDAQ-QDLNLDIEKITETGAVKPTGECSGEQS 1726
E+ KE ++E+ + DK+ Q DL L + ++ E K T +
Sbjct: 431 GEAHGRLKEQRQLSSEK--------LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 1727 PDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786
D + E + S +++E N+ ++
Sbjct: 483 LDKTKQQHQEQQALQQSTTA----------------------------KLREAQNDLEQV 514
Query: 1787 LHVIEDRDRKV---ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLS 1843
L I D+D+K+ E+LL + KE S L + L KI+A ++ +L+++N L
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 1844 EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK---ERFLDV 1900
E++ + +E L + E H K ++E++ D V + + +R L +
Sbjct: 575 EQV-------------TQLTEKLKNQSESH--KQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSER 1960
E ++ + S+ + + L+ ++ +TE L + + Q+ L+ L +
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKA-KTELLLSAEAAKTAQRAD--LQNHLDTA---Q 673
Query: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQ---ELESHQSECLHCIQVAEAEVKEKTELLQ 2017
N L+ + ++K TT LDQ++ K+++K + +LESH E E + +E ++
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-------LVK 2070
L +D E+ K + LQ + + L L EL Q L EKE+ L K
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ---LEMEKEIVSSTRLDLQK 790
Query: 2071 ESESLQA---RLSESDYEKLNVSKALEA----ALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
+SE+L++ +L++ + EK + + E ++ E R+ +T E+ +++ E
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
Query: 2124 LRVRIEADEKKQLHIAEKLK--ERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181
L + + K +++ LK + E E ++ K K L+ E E +L + EN+
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV-QMENTL 909
Query: 2182 AEVETLKTQIEEMARSLKVFELDLVTLRSE--------KENLTKQIQEKQGQLSELDKLL 2233
E + LK +E+ + +L+L +++ + K+N K+ Q+ QG ++EL K
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN-EKEEQQLQGNINEL-KQS 967
Query: 2234 SSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI 2293
S K E Q E++I KT +E Q +L +A L ++E + + + +
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQ--QLTQAAQELAAEKEKISVLQNNYEKSQ 1025
Query: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
E QL++ + L A + V ++L ++ DL+ R + + I
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE--DLISNRNQIGNQNKLIQELKTA 1083
Query: 2354 HAALEAENSKGEVE---------------TLKAKIEGMTQSLRGLELDVVTIRSEKE--N 2396
A LE +++K E + +LK K E + + + E++ + R EKE
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK-ELVNEKSKLAEIEEIKCRQEKEITK 1142
Query: 2397 LTNELQKEQ-ERISELEIINSSFENILQEK--------------EQEKVQMKEKSSTAME 2441
L EL+ + E I E+ + + + ++Q+K EQEK + +
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC---LELEKAQLLQGLDEAKNNYIV 2498
+ KE E+ A LH++ K KE + E L ++ L + L K +
Sbjct: 1203 EEEELKKEFIEKEAKLHSE---IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
Query: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558
Q V+ L ++ +D + ++ + + +N ++ L+ + + EGE + + + LEL
Sbjct: 1260 SQRRVSELEKQTDDLRGEIAVLEATV---QNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
Query: 2559 RNLTVELEQKIQVLQSKNASLQ 2580
+ +Q L +N SLQ
Sbjct: 1317 QRKLDNTTAAVQELGRENQSLQ 1338
Score = 150 bits (379), Expect = 2e-35
Identities = 234/1162 (20%), Positives = 481/1162 (41%), Gaps = 174/1162 (14%)
Query: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE---VCHLE 506
E+NL + + Q Q Q E + EE+KKE + +Q+A+ V
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 507 AELKNIKQCLN--QSQNF-AEEMK----AKNTSQETMLRDLQEKINQQEN--SLTLEKLK 557
AEL++++Q L Q++NF ++MK K T + D++ K +++ + +K+
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 558 LAVADLEKQRDCSQDL---------------LKK---------------REHHIEQLNDK 587
+L K+ QDL LKK RE E+L D+
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 588 LSKTEKE---SKALLSAL--ELKKKEYE------ELKEEKTLFSCWKSENEKL---LTQM 633
K + + S+A +S L EL K E EL++ K+ + +N+ L L +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS--- 690
E + L+ K N K Q H+ + + L+ + +H L K
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 691 -------VEVETQ----KLAYMELQQKAEFSDQ---KHQKEIENM---CLKTSQLTGQVE 733
EVET+ K + +LQQ+ E +Q + Q EI + L+T + G+
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 734 D-LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 792
L+ + QL S ++MDK++ DL + L + LK K VTN + L D+
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQL--DKTKQ 488
Query: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
H + Q S ++ E + + +Q + ++ +LE L+ K+ S L+K+
Sbjct: 489 QHQEQQAL---QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 853 CEEL-VQIK-GEIEENLM-KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909
E+L +I+ GE E ++ + ++ + + + +Q KL+ + +H+ ++ +
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
Query: 910 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
+ L+ D+V + + + EL N L +S +++ L + + + + S + +
Sbjct: 606 KAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSD---QYKQEKLILL 1026
+L T + QE + + + + ++++ S+L +YK++ L L
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 1027 QRCEETGNAYEDL---SQKYKAAQEK-----------NSKLECLLNECTSLCENRK---- 1068
Q+ EE + L S + KA++E+ N+ LE E + E K
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 1069 ----------NELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118
LE +K+ K+ +E E +Q ++ E + +++ +T+ Q
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 1119 NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ--------LMKVMKTKHECQNLE 1170
K E L E+ T+K++ +K+ + + E E+ ++ + KT E ++
Sbjct: 843 -KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
Query: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK------- 1223
+ N++KE++ + + + ++K + L+S QL+Q + L+ E +
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLK-LELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 1224 LQESEKEKECLQHELQTIRGDLETSNLQDMQ------------SQEISGLKDCEIDAEEK 1271
+ E ++ E + +++ ++G+L+ + LQ + +QE++ K+ +
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1272 YISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE----------KYELVTEL 1321
Y Q+D + L T L +E+ + Q + + +L+ EL
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 1322 NDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSL 1381
+++ + K +++ + ++ + + L ELV NE+ ++
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV------------NEKSKLAE 1128
Query: 1382 APLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441
+ + +T ++E++ H E ++ +L+ ++L Q ++ K L+ V+
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 1442 LKAENLVLSTNLRNFQGDLVKE 1463
K +L ++ + +L KE
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKE 1210
Score = 149 bits (377), Expect = 3e-35
Identities = 205/937 (21%), Positives = 420/937 (44%), Gaps = 112/937 (11%)
Query: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEK 81
EL+ QLDK K++ Q++Q S A L++ + +E + + ++Q++ + L+K
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ---IGDKDQKIQNLEALLQK 534
Query: 82 TKQKISHELQVKE---SQVNFQEGQ---LNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
+K+ IS + +E +++ EG+ LN +++ L++++ + +L+ ++ + A
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA 594
Query: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA----LQAK 191
+L+ QK + +L + N+ E+ +L+ ++KA L +
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 192 KASQTLPQATM-NHRDIARH-----QASSSVFSWQQEKTPSHLSSN----SQRTPIRRDF 241
+A++T +A + NH D A++ Q + + Q ++ + L SQ +++
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD--QLKAQNQELRNKINELEL 299
Y S EQ+ QI K +A+S S L D Q + N +L + EL
Sbjct: 715 KEKYLSLEQKTEELEG--QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELI--EKEKVLNKCRDELV--RTTAQYDQAST 355
+L+ ++ + Q+ LE K +L E+EK + K E + T Q+++ +
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 356 KY--TALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
+ T E QK+K E L + + + +K + EF++E + + + L++
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI 472
C ++K +L +++ L+ L+K QL+ L +++L +A+ + ++
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 473 KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK-----------NIKQCLNQSQN 521
+E +L+ ++ E LK SEQK +++ L+ ELK ++Q L Q+
Sbjct: 953 EEQQLQGNINE-------LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA-- 1003
Query: 522 FAEEMKAK-----------NTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS 570
A+E+ A+ SQET + LQ +E+ L + L + EK
Sbjct: 1004 -AQELAAEKEKISVLQNNYEKSQET-FKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQ 1060
Query: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
+DL+ R Q +KL + K +KA L + KKE + + K L K ++ K
Sbjct: 1061 EDLISNRNQIGNQ--NKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQKEKSLK-- 1115
Query: 631 TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
E E N +SK+ +E Q+ + + NE +++ +++ I+ + N+ D+K
Sbjct: 1116 ---EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE------SIKEITNLKDAKQ 1166
Query: 691 VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750
+ ++ QKL ELQ KA+ ++E N + Q+ + E+L+ E ++K+
Sbjct: 1167 LLIQ-QKL---ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK-------KEFIEKE 1215
Query: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
LH+E +K K+ + +E+++ L Q A++ + + E S
Sbjct: 1216 ---AKLHSE-------IKEKEVGMKKHEENEAKLTM--QITALNENLGTVKKEWQSSQRR 1263
Query: 811 RSECRLEADQSPKNSAIL----QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN 866
SE + D A+L QN D LE + +++K ++++++ +++
Sbjct: 1264 VSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT 1323
Query: 867 LMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVA 900
+++ +QS + +Q +++ + + QN +A
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMA 1360
Score = 146 bits (368), Expect = 4e-34
Identities = 201/1019 (19%), Positives = 445/1019 (43%), Gaps = 108/1019 (10%)
Query: 29 KLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE----NQRLMEICESLEKTKQ 84
KLK+E + + + L+A ++ +Q+ E ++ G L+ E + +L+E L +
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 85 KISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNT 144
++ + Q+ ++ +E Q+ + ++ +LE++LK + Q
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 145 PQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMN- 203
Q+ T L +Q DL++ + ++ ++++ LQ K + +L +
Sbjct: 496 LQQSTTAKLREAQ-------NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 204 -HRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIG 262
+ I + ++V + QEK + +Q T ++ S S+ ++ + +
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 263 KRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM----KGQVNKFQEL 318
R A +S +++L +Q E + K+++L+++++ + + + + +L
Sbjct: 609 LRAAQDRVLSLETS---VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
Query: 319 QLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA 378
Q L+ A+ L +K++ LNK +L + TA+ + LE LK+ E Q
Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE-----CIQMKA-RLTQELQQAKNMH 432
E LE +IK+ E + E + ++++ Q L Q+ ++++A L+++L+ K +
Sbjct: 726 E----ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 433 NVLQAELDK----LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488
+ + +L K L S+KQ+L EE + E Q ++I+ EL ++ E
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
Query: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
+K E E+ ++ +L + L S++ E + +N + + DL++ + +
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS---EFEKENQKGKAAILDLEKTCKELK 898
Query: 549 NSL------TLEKLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEKESKALL 599
+ L TL++ K LEK+++ S L L + + Q + L + EKE + L
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 600 SAL-------ELKKKEYEELKEEKTLFSCWKSENEKLLTQ--------MESEKENLQSKI 644
+ E KKK+ E L+ E + K+E E L Q + +EKE +
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 645 NHLETCLKT-QQIKSHEYNERVRTLEMDRENLSVE---------IRNLHNVLDSKSVEVE 694
N+ E +T +Q++S Y L ++ SVE + + N + +++ ++
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 695 TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQ 754
K A L+Q K +++++ C ++D++ + L E++++ +
Sbjct: 1079 ELKTAKATLEQ----DSAKKEQQLQERC-------KALQDIQKEKSLKEKELVNE----K 1123
Query: 755 DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC 814
AE E ++ + K+ + + E L + + + + +I ++ + +
Sbjct: 1124 SKLAEIEEIK-CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 815 RLEADQSPKNSAILQNRVDSLEFSL-----ESQKQMNSDLQ------KQCEE----LVQI 859
+ +Q +N IL+++V E L E + +++S+++ K+ EE L
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
Query: 860 KGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
+ ENL ++ QS + +R+S+L++ T + +A + ++N + E + L ++
Sbjct: 1243 ITALNENLGTVKKEWQS----SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLER 1298
Query: 920 VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKK--EMSSIISLNKREIEELTQEN 976
+ EI++L+ L+ L + L E + ++ +LN++ E+ +N
Sbjct: 1299 CLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1357
Score = 133 bits (334), Expect = 3e-30
Identities = 158/722 (21%), Positives = 313/722 (43%), Gaps = 82/722 (11%)
Query: 2204 DLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN 2263
D+ LR E ++L ++E++ EL K L ++ L +++ + + + +S ++ L+
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPD-GLVTDSSAELQSLEQ 142
Query: 2264 QLKELN------EAVAALCGDQEIMKATE-QSLDPPIEEEHQLRNSIEKLRARLEADEKK 2316
QL+E + + L + ATE + +EE LR + E+ RL + K
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202
Query: 2317 QLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
+ V+Q LK ++ V L++EL +T ++ LE E E E LK + + +
Sbjct: 203 EATVIQDLKTELLQRPGIED-VAVLKKELVQVQTLMDNMTLERER---ESEKLKDECKKL 258
Query: 2377 TQSLRGLELDVVTIRSEKEN-------LTNELQKEQERISELEIINSSFENILQEKEQEK 2429
E + +RSE ELQK + ++EL N + L +KEQ+
Sbjct: 259 QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
Query: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS-QVECLELEKA--QLL 2486
+++EK + + L+++ Q A E +L VE E +A +L
Sbjct: 319 TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
Query: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
+ L E + Y L++ L Q+ E+ +Q + EI++L +++ + E+ Q+
Sbjct: 379 EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER------QLGE 432
Query: 2547 EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMS 2606
H KEQ ++ EQ++ LQ K + L++ L+ ++ L+++L+ TK
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE 2666
TAK E Q ++ ++ ++ G+K++ L+ LL++ SK+ +
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQI--------GDKDQKIQNLEALLQK---SKENISL 541
Query: 2667 LTLENSELKKSLDCMHKDQV------EKEGKVREEIAEYQLRLH---EAEKKHQALLLDT 2717
L E +L + + EK ++E++ + +L E+ K+ Q L D
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
++ + ++ ++++ S E ++ +++ K +L+ +KA T++L + K
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT-- 659
Query: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKV 2836
++ LQ L Q A Q+KQ+ + T++
Sbjct: 660 -----------------------------AQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 2837 DELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL--CSQQSK 2894
D++T ++++ +E + EY +KY SL E+LE + LE + +Q+
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 2895 QD 2896
QD
Sbjct: 751 QD 752
Score = 129 bits (323), Expect = 6e-29
Identities = 285/1451 (19%), Positives = 590/1451 (40%), Gaps = 240/1451 (16%)
Query: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
E D D E ++ D ++ +E + L ++L+ +K EELK+E + +
Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
Query: 624 SENEK---LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680
+ K L+T +E ++L+ ++ +T EN + I+
Sbjct: 121 QQEAKPDGLVTDSSAELQSLEQQLEEAQT-----------------------ENFN--IK 155
Query: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
+ ++ + K+ ++ T+ K+++ +++ +E K ++LT ++ +Q
Sbjct: 156 QMKDLFEQKAAQLATE-----IADIKSKYDEERSLREAAEQ--KVTRLTEELNKEATVIQ 208
Query: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
L E++ + +D+ + L + D + E L D+ + +A
Sbjct: 209 DLKTELLQRPG-IEDVAVLKKELVQVQTLMDNMTLERERESEKLK--DECKKLQSQYA-- 263
Query: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIK 860
S + S+ R E + P+ A+ + L+ S+ Q N L + + Q
Sbjct: 264 -----SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
Query: 861 GEIEENLMKAEQMHQSFVAETSQR---ISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917
++EE + ++ A Q+ +LQ SA + + L K + Q L
Sbjct: 319 TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
Query: 918 DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
+++ + + Q LK L+ +E + L E ++ S + +R++ E +G
Sbjct: 379 EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE---AHG 435
Query: 978 TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYE 1037
LKE L+ EK L+ K + A + + +S L +Q K E+ N+ E
Sbjct: 436 RLKE-QRQLSSEK--LMDKEQQVA----DLQLKLSRLEEQLK----------EKVTNSTE 478
Query: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
L + ++++ + + L T+ +N+LEQ+ + Q+ A ++ +
Sbjct: 479 -LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 1098 NLMLELETVQQALRSEMTDNQN-----NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
N+ L LE ++ L +++ + N E QE +T E+ K Q E + QE
Sbjct: 538 NISL-LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 1153 N------EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFK-PQMDLEVK---EIS 1202
N EQ + + +LE+ SV E S+ N+ K Q+D+++K E+
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLET-----SVNELNSQLNESKEKVSQLDIQIKAKTELL 651
Query: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNLQDMQ---SQE 1257
L + A+ Q A L+N Q + ++K Q EL I L+ T+ LQD Q SQ
Sbjct: 652 LSAEAAKTAQ-RADLQNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 1258 ISGLKDCE---IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314
S LK+ + + E+K ++ + D+ ++ S + + L + ++ L+
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374
EL +L + E +++TR ++ + L +K
Sbjct: 768 TELSKQL-EMEKEIVSSTRLDLQKKSEALESIK--------------------------- 799
Query: 1375 EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ-HCQMSSKMS 1433
+ LT ++E Q+ L++ F +L E KI H++ + ++ + ++
Sbjct: 800 ----------------QKLTKQEEEKQI----LKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 1434 ELQ----------TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD 1483
ELQ T + ++K + +S +L+N + + KE Q G + + L +C
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG--KAAILDLEKTCKEL 897
Query: 1484 SSSL-----SSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTR 1538
L ++L + + LE+ + S LE +S+QE+ +
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE--------------LNSMQEQLIQA 943
Query: 1539 KETPSAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQELE------------ 1585
+ T K ++L+ +QS E+ ++++E+ QG +K +Q+ E
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
Query: 1586 -QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQ 1644
Q L++E++++ L+ Y E ++Q L S ES+L A ++ + + +L +A+
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQ-LQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 1645 LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNL 1704
L +S+R+ +G ++ + ++ + E S E+ + + D ++ L
Sbjct: 1063 L----ISNRNQIG--NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK- 1115
Query: 1705 DIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLG 1764
+ E + E + E Q + E+ E I E++
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEIT--KLNEELKSHKLESIKEIT-------------- 1159
Query: 1765 NQEDIHNLQLRVK-ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE 1823
N +D L ++ K E + L +E R + L +++K+ + +L + ++ K+
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQ--ELLQRVETSEGLNSDLEMHADKSSRED 1881
+ I+ EK VG K E ++ ++ + + + + ++S+ S+LE D D
Sbjct: 1220 SEIK-EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD-----D 1273
Query: 1882 IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN 1941
+ +A +E + + E+ ++ L E ++E +QT+ L L++ +N
Sbjct: 1274 LRGEIAV-----------LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Query: 1942 KQKVIVCLEEE 1952
+ L E
Sbjct: 1323 TTAAVQELGRE 1333
Score = 112 bits (280), Expect = 6e-24
Identities = 134/712 (18%), Positives = 307/712 (43%), Gaps = 75/712 (10%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Q++ ++ QLD++ + Q +Q LE+ L++ K+K + + + L+ + ++L
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
++ +K++ +LQ + E + KQ+E ++ + + +L++ +A +S
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
L ++I + ++E+L + V E ++++ E +AL +
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE------ 854
Query: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
S+V + + S +S S+ + A+ E+ +
Sbjct: 855 ---------------LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQE 317
LQ+ ++ + L++ K + +L+ ++N ++ +L + +K + Q+
Sbjct: 900 QLQV---QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
LQ + + K +K+K + + EL Q + K L+Q+L + ++L+ +
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAAE--- 1010
Query: 378 AESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
KEK Q + Q +F+ L + ++ L Q K++ L
Sbjct: 1011 ------------KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 438 ELDKLTSVKQQLENN---LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSH 494
+ L S + Q+ N ++E K EQ + + E +++++++KE +L
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL---- 1114
Query: 495 SEQKAREVCHLEAELKNIKQ--CLNQSQ--NFAEEMKA---KNTSQETMLRDLQEKINQQ 547
K +E+ + +++L I++ C + + EE+K+ ++ + T L+D ++ + QQ
Sbjct: 1115 ---KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 548 ENSL--TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
+ L + LK AV ++ + +D +KK E E+L + + E + + + E+
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEE---EELKKEFIEKEAKLHSEIKEKEVG 1228
Query: 606 KKEYEELKEEKTLFSCWKSEN-----------EKLLTQMESEKENLQSKINHLETCLKTQ 654
K++EE + + T+ +EN ++ ++++E + ++L+ +I LE ++
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288
Query: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Q + ER E + E L ++ L LD+ + V+ LQ K
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 66.6 bits (161), Expect = 4e-10
Identities = 80/426 (18%), Positives = 188/426 (44%), Gaps = 38/426 (8%)
Query: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG------ 2546
++N + + V L QEV+D + L+++ LK +++ + L + ++ +G
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 2547 -EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKM 2605
E Q ++Q E + ++Q + + K A L + ++S Y + E +
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 2606 SFVEKVNKMTAKETELQREMHEM--AQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
E++NK +L+ E+ + + A L++EL + + E + KD+
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVR---EEIAEYQLRLHEAEKKHQALLLDTNKQ 2720
K+L + + + ++ + + + +V +E+ + + ++E +K+Q L + K+
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 2721 YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK--EELNNSLKATTQILEELKKTKMDNL 2778
E + EK EE +S + ++ L + ++L + L A+ L + +
Sbjct: 315 -EQDYTKLEEK--HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371
Query: 2779 KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2838
+ +LK+E + K + L KQL++++E EK++ G + +++++
Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQRE-------------EKEQHGLQLQSEINQ 418
Query: 2839 LTTEIKELKETL--------EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCS 2890
L +++ E + L E++ +++ +DK + KL + +E L+ +V +
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 2891 QQSKQD 2896
Q + D
Sbjct: 479 LQHQLD 484
Score = 40.0 bits (92), Expect = 0.036
Identities = 59/249 (23%), Positives = 106/249 (42%), Gaps = 35/249 (14%)
Query: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK------ 2772
K YE + E L+ ++ ++ LL+ ++L SLK EELKK
Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 2773 ------TKMDNL-----KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI-LQKELSQLQ 2820
K D L + L+++ E AQ + IK K L E+K L E++ ++
Sbjct: 118 GLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIK 176
Query: 2821 AAQEKQKT-GTVMDTKVDELTTE-------IKELKETLEEKTKEADEYLDK----YCSLL 2868
+ +++++ + KV LT E I++LK L ++ D + K L
Sbjct: 177 SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236
Query: 2869 ISHEKLEKAK--EMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTE--KRLSSG 2924
+ + LE+ + E L+ + L SQ + ++ S L + GP + + ++L S
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 2925 QNKASGKRQ 2933
N+ + K Q
Sbjct: 297 VNELTQKNQ 305
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 204 bits (519), Expect = 1e-51
Identities = 279/1308 (21%), Positives = 573/1308 (43%), Gaps = 187/1308 (14%)
Query: 1644 QLQGLDLSSRSLLGIDTEDAIQGRN--------ESCDISKEHTSETTERTPKHDVHQICD 1695
++QGLD +++ + ++ + E D+S+E + H I +
Sbjct: 144 RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDE 203
Query: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
+D + +++ + + P S QSP + PG +T+ EL+ +
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSA-QSPCGS---PGMKRTESRQHLSVELADAKAK 259
Query: 1756 AL--------VPMDFLGNQEDIHNLQLRVKETSNENLRLLH-------------VIEDRD 1794
L ++++ +++ +K EN+ LL + ++
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
Query: 1795 RKVESLLNEMKELDSKLH------------LQEVQLMTKIEACIELEKIVG--------- 1833
+V+ L +E+ +LH ++ Q++ + + +E +++ G
Sbjct: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE-DQLEGTRARSDKLH 378
Query: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
EL+KEN L KL + +++E N LEM A K S ++ ++ W
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM-AQKQSMDE------SLHLGW 431
Query: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
+ + +ELS + + S+ HE E+ + L LE +N++ K + EEL
Sbjct: 432 ELEQISRTSELSE--APQKSLGHEVN------ELTSSRLLKLEMENQSLTKTV----EEL 479
Query: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
+ + G + K +LS+K++ E+ + +C +++ +KEK
Sbjct: 480 RTTV---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 2014 ELLQTLSS-------DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
+L +T+ + + L ++ HL + + SL + SQ + E ++ + KE +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA------EARVKDIEKENK 590
Query: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIE 2122
+L + + ++LS+ ++EK + K LE EKGE A L + ++E L++ I
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 2123 KLRV---RIEADEKKQLHIAEKLKERERENDSLKD---KVENLERE-LQMSEENQELVIL 2175
L++ +IEA E++ + + ++ ++ DS K+ ++E+LE+E Q+ EEN EL
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL--- 706
Query: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
+ VE+LK +MA+ +L+ L SEKE L K ++ + + ++L S
Sbjct: 707 -----RRNVESLKCASMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 2236 FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
++ L E ++ + + E S ++ L+++L++L L + E +K + + L+ +E+
Sbjct: 758 YQGLDIENQRLQKTL-ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-LEK 815
Query: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
E++ S+E+ ++LE D+K+ + ++ K A++ +E E ++I +E+
Sbjct: 816 ENK---SLEQETSQLEKDKKQ---LEKENKRLRQQAEIKDTTLE--ENNVKIGNLEKENK 867
Query: 2356 ALEAENS--KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
L E K LK + + ++ +D+ T+ + +E+L +E K Q+ ++LE
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS 2473
+ E I KE+ + + ++L+++L+ + L E + K L +
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE------STLKKSLEIKEEKIAALEA 981
Query: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD 2533
++E QL Q L K NY L+ Q QD
Sbjct: 982 RLEESTNYNQQLRQELKTVKKNYEALK-----------------------------QRQD 1012
Query: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
+E++V + GE W+ ++ E ++++ ++ ++ NA+LQ + L++ K L
Sbjct: 1013 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1072
Query: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
E + + ++ + + + T LQ + ++ + + L + + N+ A QLL
Sbjct: 1073 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA---QLL 1129
Query: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
+++ S +++ + + E +LK D + KD + E + +EY+ + KH
Sbjct: 1130 IQQ-SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI----SKH-GT 1183
Query: 2714 LLDTNKQYEVEIQ----TYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
L +K EVE + Y + L K + +K +LK +E++ K + E
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK----MLKVEQEKMLLENKNHETVAAE 1239
Query: 2770 LKKT--KMDNLKYV-NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
KK + D L + +QL KE E Q K L + E+ L+ E S+L +E+
Sbjct: 1240 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL---KEQY 1296
Query: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
+ + TK++ + +LK LEE+ + LD+ +L++ + L
Sbjct: 1297 QQLDITSTKLNNQCELLSQLKGNLEEENR---HLLDQIQTLMLQNRTL 1341
Score = 184 bits (468), Expect = 9e-46
Identities = 253/1084 (23%), Positives = 480/1084 (44%), Gaps = 153/1084 (14%)
Query: 1852 DHQE-LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVENELSRI 1907
+H E +++ E +GL+ HA S++ G K +S + D + ++ R+
Sbjct: 206 EHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
Query: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
R E + L + +LE ++ E L+++N N LS S R R EL
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL----------LSDARSAR-MYRDEL 312
Query: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA---EVKEKTELLQTLSSDVS 2024
D + +K +D+L ++ S E LH I+ +A E+KE ++L + +
Sbjct: 313 DALREKAVRVDKLESEV--------SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
+ L+ +KL LEK++ L ++E + K+ E L++E+ +L+ +S
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 2085 EKLNVSKALE-----AALVEKGEFAL----------RLSSTQEEVHQLRRGIEKLRVRIE 2129
E L++ LE + L E + +L RL + E L + +E+LR ++
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
+ E A K+ + E+EN L KVE LE E+ +++ + + +N ++ K
Sbjct: 485 SVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQ----NCQNLSKDLMKEKA 536
Query: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Q+E+ T+ + +EN +QI+ + + L++ +SS + + AE +
Sbjct: 537 QLEK-------------TIETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEAR 581
Query: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
+K+ ++ + K L+E++ K T L E+ Q++ +E + +
Sbjct: 582 VKD--------IEKENKILHESI----------KETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE-IARTNQEHAALEAENSKGEVET 2368
E E+ + +L E +LL+ ++ NL+ E I QE++ LE EN K + +T
Sbjct: 624 GERAEELE----NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-KT 678
Query: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
L + + +T L LE + + ++ENL E + + +++ EN +E E E
Sbjct: 679 LDS-FKNLTFQLESLEKE--NSQLDEENLELRRNVESLKCASMKMAQLQLEN--KELESE 733
Query: 2429 KVQMKE------KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
K Q+K+ S E L+ + L+ L E K Q L S+++ LE+E
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
L + L+E K + + ++++E + LE++ ++ + K Q++ + + + + +
Sbjct: 794 QTLQKNLEELKIS--------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL-ENELELTK 2601
++ K+ LE N+ KI L+ +N +L + + + S L E E E +
Sbjct: 846 EI-------KDTTLEENNV------KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
+ K + ++ +T +E +L E + Q +L E+L+ E ++ + LL + +S+
Sbjct: 893 LVKRATIDIKTLVTLRE-DLVSEKLKTQQMNNDL-EKLTHELEKIGLNKERLLHDEQSTD 950
Query: 2662 D---QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LL 2715
D +L E LE S LKKSL+ E+IA + RL E+ +Q L L
Sbjct: 951 DSRYKLLESKLE-STLKKSLEIKE-----------EKIAALEARLEESTNYNQQLRQELK 998
Query: 2716 DTNKQYEVEIQTY-REKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE------ 2768
K YE Q E++ +S + + + + S+E LK +++E
Sbjct: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWE--RESQETTRELLKVKDRLIEVERNNA 1056
Query: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT 2828
L+ K + QL+ +N Q ++ L + L+E+ LQ + ++LQ +
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116
Query: 2829 -GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887
T + + +L + L+ E KE ++ Y SL+ HEKLE E ++
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1176
Query: 2888 LCSQ 2891
L S+
Sbjct: 1177 LISK 1180
Score = 161 bits (407), Expect = 1e-38
Identities = 319/1517 (21%), Positives = 624/1517 (41%), Gaps = 248/1517 (16%)
Query: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Q L +L K + ++ + +L+ L KQ++E + E L++EN L+ S
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
+ ++ ++E V +++KLE E+ R K L D+
Sbjct: 307 MYRDELD---ALREKAV------------RVDKLESEVSRYKERLH---------DI--- 339
Query: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK-------KA 193
++Y ++ E+LKE +E + LE +++ +A+ +
Sbjct: 340 ----------------EFYK-ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
+A ++ ++ R + +E ++ + + E E
Sbjct: 383 ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD------ESLHLGWELEQI 436
Query: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
S L + + + +S LL +L+ +NQ L + EL + ++G +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLL-KLEMENQSLTKTVEELRTTVD----SVEGNAS 491
Query: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
K L++EK L +K ++L +E+V+ L ++ +L + +
Sbjct: 492 KI----LKMEKENQRLSKKVEIL---ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
R+N+E LEQ E E Q S +QRS I +AR+ ++ K +H
Sbjct: 545 LRENSERQIKILEQ---ENEHLNQTVSSLRQRS-------QISAEARVKDIEKENKILHE 594
Query: 434 VLQAELDKLTSV---KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
++ KL+ + K+Q++ LE +K+K RAE EL + ++KEN L
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-----------ELENELHHLEKENEL 643
Query: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
L+ +++ +L+ + I + L Q + E++ +N + L D + + Q S
Sbjct: 644 LQ-------KKITNLKITCEKI-EALEQENS---ELERENRKLKKTL-DSFKNLTFQLES 691
Query: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
L E +L +LE +R+ + LK + QL + + E E + L LEL K ++
Sbjct: 692 LEKENSQLDEENLELRRNV--ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
+ + + + EN++L + EN KI LE+ L+ ++++ +TL+
Sbjct: 750 KTERLEVSYQGLDIENQRL----QKTLENSNKKIQQLESELQDLEMEN-------QTLQK 798
Query: 671 DRENLSVEIRNLHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
+ E L + + L + ++KS+E ET +L + Q + E + Q EI++ L+ + +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV- 857
Query: 730 GQVEDLEHKLQLLSNEI-MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
++ +LE + + LS EI + K+ C + E E+ ++L+K + T + L++
Sbjct: 858 -KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATIDIKTLVTLREDLVSEK 915
Query: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
+ ++ + + E L +QS +S R LE LES + + +
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDS-----RYKLLESKLESTLKKSLE 970
Query: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
+++ E++ ++ +EE+ +Q+ Q V + + + + Q++ Q+ + +S
Sbjct: 971 IKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGE 1026
Query: 907 ENK-EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
+NK E+E Q ++ + + E++++N L+ + L+ + L + + + I
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
Query: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
+R+ L ++N TL+ NA L E L +S S N + + + + S + + ++
Sbjct: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN---QNAQLLIQQSSLENENESVI 1143
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+R EDL Y + + + KLE L S E+ ++ LK A H+
Sbjct: 1144 KER--------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA----HKNL 1191
Query: 1086 LTKLAFAEERNQNLML---ELETVQQALRSE----MTDNQNNSKSEAGGLKQEIMTLKEE 1138
+ E+R L+ +LE +++ L+ E + +N+N+ A E L E
Sbjct: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA-----EYKKLCGE 1246
Query: 1139 QNKMQKEVNDLLQENEQL------MKVMKTKHECQNLESEPIRNSVKERESE-------- 1184
+++ + LL+E E L +K + + + E + +KE+ +
Sbjct: 1247 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
Query: 1185 RNQCNFKPQMDLEVKEIS---LDSYNAQLVQ----LEAMLRNKEL----------KLQES 1227
NQC Q+ ++E + LD ++Q LE + +K+L KL E
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 1228 EKEKECLQHELQ-----------TIRGDLETSNLQDM---------QSQEISGLKDCEID 1267
++KE L+ ++ RG+ T ++ + + Q+ L D
Sbjct: 1367 RRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSD 1426
Query: 1268 AEEKYISGPHE--------LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
+ E ++ PH+ S S D L +TMN L + ++ A ++ T
Sbjct: 1427 SSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDL-----VQSMVLAGQWTGST 1481
Query: 1320 ELNDSRSECITATRKMAEEVGKLLNEV-----KILNDDSGLLHGELV--------EDI-P 1365
E + + T R+ +E+G + +N +G +LV EDI P
Sbjct: 1482 ENLEVPDDISTGKRR--KELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISP 1539
Query: 1366 GG-----EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQS-EHK 1419
G G + + P SL S S + S EV+ Q + S S E
Sbjct: 1540 QGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFS 1599
Query: 1420 ILHDQHCQMSSKMSELQ 1436
+LHD SS S +Q
Sbjct: 1600 LLHDHEAWSSSGSSPIQ 1616
Score = 154 bits (389), Expect = 1e-36
Identities = 223/982 (22%), Positives = 450/982 (45%), Gaps = 152/982 (15%)
Query: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
E + ++ ER+ L S + K E Q L ++ I+ E++
Sbjct: 209 ETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELE 268
Query: 2011 EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
EKTE L ++ ++ + LQ++ +L D+++ + + EL+ +EK + V
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL-----REKAVRVD 323
Query: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
+ ES +R E ++ + KA L E + L + E+ QL G ++
Sbjct: 324 KLESEVSRYKERLHD-IEFYKARVEELKEDNQVLLETKTMLED--QLE-GTRARSDKLHE 379
Query: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERE---LQMSEENQ-----------ELVILD 2176
EK+ L + KL + E E D + K+E L E L+M+++ E +
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 2177 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
+E S+A ++L ++ E+ S L+ L E ++LTK ++E + + ++ S
Sbjct: 440 SELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEGNAS-- 491
Query: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296
K L EKE + K VE+L+N++ + +++ ++ + ++E+
Sbjct: 492 KILKMEKENQRLSKK------VEILENEIVQ----------EKQSLQNCQNLSKDLMKEK 535
Query: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
QL +IE LR E +Q+ +L+Q E+EH L V +L + +I+
Sbjct: 536 AQLEKTIETLRENSE----RQIKILEQ--ENEH----LNQTVSSLRQRSQIS-------- 577
Query: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
++ V+ ++ + + + +S++ + I EK + EL+ +E+ E + +
Sbjct: 578 -----AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 2417 SFENILQEKE--QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
++ +E E Q+K+ + + +E L+ + EL L ++ K NL+ Q
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK----NLTFQ 688
Query: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR----LKNQ 2530
+E LE E +QL + E + N L+ + + Q + K+ LE + E++ + LK
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKAS 747
Query: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQSKNASLQDTLEVLQSS 2589
+ E+L ++ E+Q ++ LE N ++ LE ++Q L+ +N +LQ LE L+ S
Sbjct: 748 FKKTERLEVSYQGLDIENQRL-QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
K LE +L++E + Q+T++L+++ K +L E
Sbjct: 807 SKRLE-------------------------QLEKENKSLEQETSQLEKD----KKQLEKE 837
Query: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK-VREEIAEYQ---LRLHE 2705
+ L ++ ++K+ TLE + +K +EKE K + +EI Y+ +RL E
Sbjct: 838 NKRLRQQA-----EIKDTTLEENNVKIG-------NLEKENKTLSKEIGIYKESCVRLKE 885
Query: 2706 AEKKHQALLLDTNKQYEVEIQTY---REKLTSKEECLSSQKLEIDLLKSS---------K 2753
EK+++ L+ K+ ++I+T RE L S++ L +Q++ DL K + K
Sbjct: 886 LEKENKELV----KRATIDIKTLVTLREDLVSEK--LKTQQMNNDLEKLTHELEKIGLNK 939
Query: 2754 EELNNSLKATTQILEELKKTKMDN-LKYVNQLKKENERA-QGKMKLLIKSCKQLEEEKEI 2811
E L + ++T +L ++K+++ LK ++K+E A + +++ +QL +E +
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 2812 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH 2871
++K L+ Q++++ M ++ E + + +E T+E + D+ + ++
Sbjct: 1000 VKKNYEALKQRQDEER----MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 2872 EKLEKAKEMLETQVAHLCSQQS 2893
L+ K+ L+TQ+ L +Q +
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNN 1077
Score = 153 bits (387), Expect = 2e-36
Identities = 239/1191 (20%), Positives = 510/1191 (42%), Gaps = 153/1191 (12%)
Query: 327 VELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
VEL + + + + R EL T Q + +E +LK+L ++ +A SAR +
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 387 QKIKEKEK-----EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
+ +EK + + E+SR + ++ KAR+ ++ K + VL L+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEF----YKARV----EELKEDNQVL---LET 359
Query: 442 LTSVKQQLE------NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
T ++ QLE + L E +++ + + +++ + R+ +EE+ +EN L+
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
+Q E HL EL+ I + S+ ++ ++ T R L+ ++ Q + T+E+
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEA-PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
L+ V +E K+ K EKE++ L +E+ + E ++E+
Sbjct: 479 LRTTVDSVEGNAS------------------KILKMEKENQRLSKKVEILENEI--VQEK 518
Query: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
++L +C + + + + EK +++ + E +K + ++ N+ V +L R +
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQI 576
Query: 676 SVEIR----NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
S E R N + +S++ + KL+ +E +++ + +H KE + +L +
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENE 633
Query: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
+ LE + +LL +I + + + A L+ +++ L + L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEA--------LEQENSELERENRKLKKTL------ 679
Query: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM---NSD 848
SF N+ + S+ E S Q + + L+ V+SL+ + Q+ N +
Sbjct: 680 ---DSFKNLTFQLESLEKENS-------QLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
L+ + E+L + ++ + K E++ S+ + +QR+ K E+++ + L L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
E + + LQ ++++ +++L+K N LE +L+ + L E K + +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
+EE + G L++ N +L++E + + ++S + E EK EL + + L+
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKE-IGIYKES---CVRLKELEKENKELVKRATIDIKTLV 905
Query: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086
EDL + Q+ N+ LE L +E + N++ L + ++
Sbjct: 906 -------TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
Query: 1087 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE--------- 1137
+KL +++ + E +A E T+ + E +K+ LK+
Sbjct: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
Query: 1138 -------EQNKMQKE----VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186
E NK ++E +LL+ ++L++V + Q E + ++ +K+ E++ N
Sbjct: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ-AEKQALKTQLKQLETQNN 1077
Query: 1187 QCNF------KPQMDLEVKEISLDSYNAQLVQLE----------AMLRNKELKLQES--E 1228
+ + L+ + +L + NA+L Q+E M +N +L +Q+S E
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKL-QVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 1229 KEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288
E E + E + ++ L S ++D + E+ L + + E IS L ++ +
Sbjct: 1137 NENESVIKEREDLK-SLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEV 1193
Query: 1289 LQCSLQTTMNKL----NELEKICEILQAEKYELVTELNDSRSECITATRKMAEE------ 1338
L+ N+L +LE + ++L+ E+ +++ E N + +K+ E
Sbjct: 1194 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGENDRLNH 1252
Query: 1339 -VGKLLNEVKILNDD-----SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
+LL E ++L D S L + +L + EF + + + + +N E
Sbjct: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312
Query: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-ELQTYVDSL 1442
L+ ++ L ++ +L +++ L +Q+ + E + Y+D L
Sbjct: 1313 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
Score = 152 bits (385), Expect = 4e-36
Identities = 270/1234 (21%), Positives = 525/1234 (42%), Gaps = 172/1234 (13%)
Query: 18 QKIQELEGQLDKLKKEK--------------------QQRQFQLDSLEAALQKQKQK--- 54
Q+++++E +L +L++E +++ ++D LE+ + + K++
Sbjct: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHD 338
Query: 55 VENEKTEGTNLKRENQRLME----ICESLEKTKQKIS--HELQVKESQVNFQEGQLNSGK 108
+E K LK +NQ L+E + + LE T+ + HEL+ + Q+ + + +
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 109 KQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK 168
K +EL LE +Q+ QS D SL+ ++I T S + + L
Sbjct: 399 DMDRKKIEELMEENMTLEMAQK--QSMDESLHLGWELEQISRT-----SELSEAPQKSLG 451
Query: 169 EKYNKEVEER-KRLEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
+ N+ R +LE E ++L ++ T+ N I + + + S + E
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTL-QIGKRDANSSFFDNSSSPHLLDQLK 284
+ + Q ++ S + ++ + TL + +R +N + L+
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR 571
Query: 285 AQNQ---ELRNKINELELRLQGHE--KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
++Q E R K E E ++ HE KE +++K + + Q++K EK + +
Sbjct: 572 QRSQISAEARVKDIEKENKIL-HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE-QKIKEKEKEFQE 398
+EL + + K T L+ +K+ + +++N+E R + + +K + K
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIE---ALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK- 457
+L ++ LD+E ++++ R + L+ A LQ E +L S K+QL+ LE K
Sbjct: 688 QLESLEKENSQLDEENLELR-RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 458 --QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQC 515
+K R E ++Q I+ L++++E K+ L+S E+ LE E + +++
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES-------ELQDLEMENQTLQKN 799
Query: 516 LNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLK 575
L EE+K + E + + + K +QE S LEK K LEK+ + +
Sbjct: 800 L-------EELKISSKRLEQL--EKENKSLEQETS-QLEKDK---KQLEKENKRLRQQAE 846
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL----KEEKTLFSCWKSENEKLLT 631
++ +E+ N K+ EKE+K L + + K+ L KE K L + + L+T
Sbjct: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT 906
Query: 632 QME---SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
E SEK Q N LE T +++ N+ R L ++ + L + L+S
Sbjct: 907 LREDLVSEKLKTQQMNNDLEKL--THELEKIGLNKE-RLLHDEQSTDDSRYKLLESKLES 963
Query: 689 ---KSVEVETQKLAYME--LQQKAEFSDQ---------------KHQKEIENMCLKTSQL 728
KS+E++ +K+A +E L++ ++ Q K +++ E M + +
Sbjct: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1023
Query: 729 TGQVEDLEHKLQLLSNEIMD-KDRCYQ------DLHAEYESLRDLLKSKDASLVTNEDHQ 781
+G+ E + Q + E++ KDR + L AE ++L+ LK + N + Q
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ---NNNLQ 1080
Query: 782 RSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLES 841
+LA +Q ++ + ++ ++ ++ ++E S L N+ L S
Sbjct: 1081 AQILALQRQT------VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134
Query: 842 QKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAE 901
+ N + K+ E+L + + ++ K E +H+ +E ISK SAH+N
Sbjct: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN---- 1190
Query: 902 TLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 961
LE + ++L + +L K LED K L++ E + LE K ++
Sbjct: 1191 ----LEVEHRDL----------EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1236
Query: 962 ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER-------EKSISEL 1014
+ E ++L EN L + L +E L ++ + ++ E S+L
Sbjct: 1237 AA----EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1292
Query: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ- 1073
+QY+Q + + N E LSQ +E+N LL++ +L + LEQ
Sbjct: 1293 KEQYQQLDI----TSTKLNNQCELLSQLKGNLEEENRH---LLDQIQTLMLQNRTLLEQN 1345
Query: 1074 --LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE 1131
K+ F E ++++ KL EL ++ L ++ D +
Sbjct: 1346 MESKDLFHVEQRQYIDKLN-----------ELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1394
Query: 1132 IMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
+TLK K+ K D+ +E ++ + + T+ +
Sbjct: 1395 WITLK--MRKLIKSKKDINRERQKSLTLTPTRSD 1426
Score = 144 bits (362), Expect = 2e-33
Identities = 253/1194 (21%), Positives = 492/1194 (41%), Gaps = 178/1194 (14%)
Query: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL 604
++Q S+ L K + L ++ + + L + +EQ+ +L + ++E+ LLS
Sbjct: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
Query: 605 KKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER 664
+ +EL + E + ++ESE + +++ +E Y R
Sbjct: 305 ARMYRDELDALR--------EKAVRVDKLESEVSRYKERLHDIEF-----------YKAR 345
Query: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
V L+ D + V +ET+ + +L+ SD+ H+ E EN+ LK
Sbjct: 346 VEELKEDNQ-----------------VLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 725 TSQLTGQVE-DLEHKL------QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN 777
++E D++ K + ++ E+ K + LH +E L + ++ + S
Sbjct: 389 AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE-LEQISRTSELS---- 443
Query: 778 EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD----------QSPKNSAI 827
E Q+S L + + E S+ E R D + K +
Sbjct: 444 EAPQKS-LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
Query: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
L +V+ LE + +KQ + Q ++L++ K ++E+ + + E S+R K
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI--------ETLRENSERQIK 554
Query: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
+ E + H N +T+S+L + + + +A +++++K N +L +S+KE
Sbjct: 555 ILEQENEHLN---QTVSSLRQRSQ---------ISAEARVKDIEKENKILHESIKETSSK 602
Query: 948 SETLSLEKKEMSSIISLNKRE---IEELTQENGTLKEINASLNQEKMNL------IQKSE 998
+ EK+++ + K + EEL E L++ N L ++ NL I+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYED------LSQKYKAAQEKNSK 1052
+ ++ + + + D +K L +E E+ + K A K ++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 1053 LECLLNECTSLCENRKNELEQLKEAFAK-------------EHQEFLTKLAFAEERNQNL 1099
L+ E S E K LE LK +F K E+Q L + ++ Q L
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 1100 MLELETVQ---QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
EL+ ++ Q L+ + + + +SK L++E +L++E ++++K+ L +EN++L
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 1157 MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN--------- 1207
+ + K + I N KE ++ + + + +KE+ ++
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEID 1267
LV L L +++LK Q+ + E L HEL+ I G + L D QS + S K E
Sbjct: 902 KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLESK 960
Query: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSE 1327
E L + A L+ L+ + N +L + + ++ + YE + + D
Sbjct: 961 LESTL---KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK-KNYEALKQRQD-EER 1015
Query: 1328 CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387
+ ++ ++ E K E + + + L+E + + L L+
Sbjct: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
Query: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN- 1446
N+ +Q LQ + +SLQ ++ L Q+ ++ + S L + SL +N
Sbjct: 1076 NN---------NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126
Query: 1447 --LVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGD--SSFYRALLEQ 1502
L+ ++L N ++KE + + SL S + D L L + +S Y +L+ +
Sbjct: 1127 QLLIQQSSLENENESVIKERE------DLKSLYDSLIKDHEKLELLHERQASEYESLISK 1180
Query: 1503 TGDM-SLLSNLEGAVSANQCSVDEVFCSSLQEENLTR---------------KETPSAPA 1546
G + S NLE + +++ Q E+L + ET +A
Sbjct: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1240
Query: 1547 KGV-EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE 1605
K + E + L Y Q L++ E + + + L+ LL++ + E L ++
Sbjct: 1241 KKLCGENDRLNHTYSQLLKETE--------VLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1292
Query: 1606 NEQWQQ-KLTSVTLEMESKLAAEKKQTEQLSLELEVARL--QLQGLDLSSRSLL 1656
EQ+QQ +TS L + +L ++ K +LE E L Q+Q L L +R+LL
Sbjct: 1293 KEQYQQLDITSTKLNNQCELLSQLKG----NLEEENRHLLDQIQTLMLQNRTLL 1342
Score = 139 bits (349), Expect = 6e-32
Identities = 204/953 (21%), Positives = 411/953 (43%), Gaps = 126/953 (13%)
Query: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--------NEKTEGTNLK 66
R +K++ LE ++ + K+ Q Q +L L K+K ++E N + + L+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 67 RENQRLMEICESLEKTKQKISHELQVK--ESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
+EN+ L + SL + Q IS E +VK E + + ++ K+E E ++ K E
Sbjct: 558 QENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 125 LERSQQAAQSADVSLNPCN--------TPQKIFTTPLTPSQYYS----GSKYEDLKEKYN 172
LE ++ + A+ N + +KI +T + + S+ E K
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 173 KEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
K ++ K L ++++L+ K + L + + R +S+ Q + L S
Sbjct: 677 KTLDSFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ----LKAQNQ 288
++ + + F + + S L I + + +++ L+ L+ +NQ
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 289 ELRNKINELEL---RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
L+ + EL++ RL+ EKE K ++ QLEK K +L EKE + + E+
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKS----LEQETSQLEKDKKQL-EKENKRLRQQAEIKD 849
Query: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
TT + + + K LE++ K L++++ +++ ++KE EKE +E + R
Sbjct: 850 TTLE--ENNVKIGNLEKENKTLSKEIGIYKESCV--------RLKELEKENKELVKRATI 899
Query: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
+TL + ++ L E + + M+N +L+KLT +++ N K++L EQ
Sbjct: 900 DIKTL----VTLREDLVSEKLKTQQMNN----DLEKLTHELEKIGLN----KERLLHDEQ 947
Query: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
+ S+ K + E K E+ L KS E K ++ LEA L+ + N +Q +E
Sbjct: 948 STDDSRYK-------LLESKLESTLKKS-LEIKEEKIAALEARLE---ESTNYNQQLRQE 996
Query: 526 MKAKNTSQETML-RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
+K + E + R +E++ Q ++ E K + ++ +++LLK +
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE----RESQETTRELLK--------V 1044
Query: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ---MESEKENLQ 641
D+L + E+ + L + + K + ++L+ ++N L Q ++ + +LQ
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLE----------TQNNNLQAQILALQRQTVSLQ 1094
Query: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
+ L+T Q+++ N + +L L ++ +L N +S E E K Y
Sbjct: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
Query: 702 EL---QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
L +K E ++ E E++ K G ++ L++ ++ D+
Sbjct: 1155 SLIKDHEKLELLHERQASEYESLISKH----GTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210
Query: 759 EYESLRDLLK-SKDASLVTNEDHQRSLLAFD----QQPAMHHSFANIIGEQGSMPSERSE 813
+ E L +LK ++ L+ N++H+ + + ++H+++ ++ E + ++
Sbjct: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270
Query: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
+ + S L+ L+ + ++ L QCE L Q+KG +EE E
Sbjct: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE-----ENR 1325
Query: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE-----KELQLLNDKVE 921
H +T LQ T QN+ ++ L +E ++ EL+ +K+E
Sbjct: 1326 HLLDQIQTLM----LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1374
Score = 134 bits (338), Expect = 1e-30
Identities = 350/1760 (19%), Positives = 710/1760 (40%), Gaps = 264/1760 (15%)
Query: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939
E +RI L DT A V A N+E L + E+ ++ + + +E
Sbjct: 140 EFIERIQGLDFDTKAA--VAAHIQEVTHNQENVFDL-------QWMEVTDMSQED--IEP 188
Query: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES 999
LK + L + L E+ E S I E + L + M + +
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQH 248
Query: 1000 FANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE 1059
+ + + + I L + +++ LL +E E + + K Q++N L L++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNL---LSD 301
Query: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
S ++EL+ L+E + + KL R + + ++E + + DNQ
Sbjct: 302 ARS-ARMYRDELDALREKAVR-----VDKLESEVSRYKERLHDIEFYKARVEELKEDNQ- 354
Query: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
+ E T+ E+Q + + +D L E E+ +K K +E + R ++
Sbjct: 355 --------VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 1180 ERESERNQCNFKPQMDLEV-KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
E E M LE+ ++ S+D +LE + R EL SE ++ L HE+
Sbjct: 407 ELMEEN--------MTLEMAQKQSMDESLHLGWELEQISRTSEL----SEAPQKSLGHEV 454
Query: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
+L +S L ++ + S K E EL T+ D+ S M
Sbjct: 455 N----ELTSSRLLKLEMENQSLTKTVE------------ELRTTV-DSVEGNASKILKME 497
Query: 1299 KLNE-LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLH 1357
K N+ L K EIL+ E + + S C ++ + +E +L ++ L +
Sbjct: 498 KENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE------ 547
Query: 1358 GELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417
N + + + L++ N + + T+S + + + + ++ E
Sbjct: 548 ----------------NSERQIKI--LEQENEHLNQTVSSLRQRSQISA-EARVKDIEKE 588
Query: 1418 HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ--GDLVKEMQLGLEEGLVPS 1475
+KILH+ + SSK+S+++ +K E L +++ G+ +E++ L
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKE-------LEHYKEKGERAEELENELHH----- 636
Query: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDM--SLLSNLEGAVSANQCSVDEVFCSSLQE 1533
LE+ ++ ++NL+ ++ + E S L+
Sbjct: 637 ------------------------LEKENELLQKKITNLK--ITCEKIEALEQENSELER 670
Query: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
EN K+T + +LESL EK +++ + + + ++ L+ S +
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESL--------EKENSQLDEENLELRRNVESLK-CASMKMA 721
Query: 1594 ELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS-----LELEVARLQLQGL 1648
+L K+ SE EQ ++ L L A K+TE+L L++E RLQ + L
Sbjct: 722 QLQLENKELESEKEQLKKGL--------ELLKASFKKTERLEVSYQGLDIENQRLQ-KTL 772
Query: 1649 DLSSRSLLGIDTE--------DAIQGRNESCDISKEHTS--ETTERTPKHDVHQICDKDA 1698
+ S++ + +++E +Q E IS + E ++ + + Q+ +KD
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL-EKDK 831
Query: 1699 QQDLNLDIEKITETGAVKPTG-ECSGEQSPDTNYEPPGEDKTQG--SSECISELSFSGPN 1755
+Q L + +++ + +K T E + + + E K G C+ N
Sbjct: 832 KQ-LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 1756 ------ALVPMDFLGN-QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808
A + + L +ED+ + +L+ ++ +N+ +L H +E E LL++ + D
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 1809 -SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN 1867
S+ L E +L + ++ +E+++ ++ + L +LE + +Q+L Q ++T +
Sbjct: 951 DSRYKLLESKLESTLKKSLEIKE------EKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 1868 SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEV 1927
L+ D+ ++ ++ W+ + EL +++ +E L+A+ +
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064
Query: 1928 VQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987
++T+ LE N N Q I+ L+ + +V E+N T L + K++ +
Sbjct: 1065 LKTQLKQLETQNNNLQAQILALQRQ-TVSLQEQN-------------TTLQTQNAKLQVE 1110
Query: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2047
L S + ++ Q A+ +++ +L ++ ++K++ L+ SL KD + L
Sbjct: 1111 NSTLNSQSTSLMN--QNAQLLIQQ-----SSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107
L E Q + E E L+ + +L++ + E ++ L +KG+
Sbjct: 1164 ELLH---ERQAS----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL---- 1212
Query: 2108 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE 2167
E++ ++ + +E+ ++ +E K +A + K+ END L L +E ++ +
Sbjct: 1213 ----EDLEKMLK-VEQEKMLLE--NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
Query: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK----QIQEKQ 2223
+ + + NSK E L+ + ++ + ++ L ++ E L++ +E +
Sbjct: 1266 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR 1325
Query: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
L ++ L+ ++LLE+ +++ E + ++ L N+L+ E + DQ K
Sbjct: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEEKIMDQ--YK 1382
Query: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER 2343
+ S PP + R + L+ R KK + +E + L R ++ E
Sbjct: 1383 FYDPS--PP-----RRRGNWITLKMRKLIKSKKDI-----NRERQKSLTLTPTRSDSSEG 1430
Query: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENL------ 2397
L++ + + ++ NS + +TL K L + ENL
Sbjct: 1431 FLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDI 1490
Query: 2398 -TNELQKEQERIS-ELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ-LKELNERV 2454
T + +KE ++ IN S N + K + K +T+ E + Q + + +
Sbjct: 1491 STGKRRKELGAMAFSTTAINFSTVN-SSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTG 1549
Query: 2455 AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
+ +H + A + +S A L + A NN QS +G + D +
Sbjct: 1550 SRVHASRPASLDSGRTSTSNSN----NNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHE 1605
Query: 2515 QKLEKKDEEISRLKNQIQDQEQLVSKLSQ-VEGEHQLWK--EQNLELRNLTVELEQ--KI 2569
I LK Q + L K+S+ +E H K E+ L LE+ K+
Sbjct: 1606 AWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKL 1665
Query: 2570 QVLQSKNASLQDTLEVLQSS 2589
+Q K++S ++ L+ + S
Sbjct: 1666 TSVQIKSSSQENLLDEVMKS 1685
Score = 134 bits (337), Expect = 1e-30
Identities = 287/1331 (21%), Positives = 557/1331 (41%), Gaps = 217/1331 (16%)
Query: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
+ + L+ EL AK L+ EL++ T + LE+ + +L R +Q +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----ENMNLL 299
Query: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF---AEEMKAKN-- 530
RS + E + L+ +KA V LE+E+ K+ L+ + + EE+K N
Sbjct: 300 SDARSARMYRDELDALR----EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQV 355
Query: 531 -TSQETMLRDLQEKINQQENSL-TLEK----LKLAVADLEKQRDCSQDLLKKREHHIEQL 584
+TML D E + + L LEK LK + D+E +RD + KK E +E+
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR---KKIEELMEE- 411
Query: 585 NDKLSKTEKES--KALLSALELKK-KEYEELKE--EKTLFSCWKSENEKLLTQMESEKEN 639
N L +K+S ++L EL++ EL E +K+L L ++E E ++
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471
Query: 640 LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN-VLDSKSVEVETQKL 698
L + L T + + + + ++ +E + + LS ++ L N ++ K Q L
Sbjct: 472 LTKTVEELRTTVDSVEGNA----SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 699 AYMELQQKAEFSD------QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
+ +++KA+ + +++I+ + + L V L + Q+ +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI------SAEAR 581
Query: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
+D+ E + L + +K + L E +R + ++ H+ E+G E
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEHYK------EKGERAEELE 631
Query: 813 ECRLEADQSPKNSAILQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMK 869
E K + +LQ ++ +L+ + +E+ +Q NS+L+++ +L + + +
Sbjct: 632 N---ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 870 AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQE 929
E + + E SQ +E+ +NV E+L K +LQL N ++E+E+ ++
Sbjct: 689 LESLEK----ENSQLD---EENLELRRNV--ESLKCASMKMAQLQLENKELESEK---EQ 736
Query: 930 LKKSNHLLEDSLKE---LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
LKK LL+ S K+ L++ + L +E + + + + ++I++L E L+ N +L
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
Q+ + ++ S +++ KS+ + + Q +++K K
Sbjct: 797 -QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK---------------------KQL 834
Query: 1047 QEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
+++N +L + ++K+ +E+ K+ E+ N+ L E+
Sbjct: 835 EKENKRL---------------RQQAEIKDTTLEENN---VKIGNLEKENKTLSKEIGIY 876
Query: 1107 QQA-LRSEMTDNQNNSKSEAGGLK-QEIMTLKE----EQNKMQKEVNDLLQENEQLMKVM 1160
+++ +R + + +N + + + ++TL+E E+ K Q+ NDL + +L K+
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
K + E + K ES+ K LE+KE ++ LEA
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKK---SLEIKE-------EKIAALEA----- 981
Query: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE--------ISGLKD-CEIDAEE- 1270
+L+ES + L+ EL+T++ + E L+ Q +E ISG + E +++E
Sbjct: 982 --RLEESTNYNQQLRQELKTVKKNYEA--LKQRQDEERMVQSSPPISGEDNKWERESQET 1037
Query: 1271 --KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSEC 1328
+ + L + +NA LQ Q +L +LE LQA+ L + + +
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
Query: 1329 ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE---QHPVSLAPLD 1385
T + A KL E LN S L + + + E NE + L L
Sbjct: 1098 TTLQTQNA----KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1153
Query: 1386 ES--NSYEHLTLSDKEVQMHFAELQEKFLSLQS-------EHKILHDQHCQMSSKMSELQ 1436
+S +E L L + + L K +L+S EH+ L D++ Q+ + +L+
Sbjct: 1154 DSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLE 1213
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCV-------PDSSSLSS 1489
LK E + +N + + +L E + S + D +L S
Sbjct: 1214 DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 1490 LGDSSFYRALLEQTGDMSLLSNLEGAVSA---------NQCSVDEVFCSSLQEENLTRKE 1540
L ++S LEQT + S L+ NQC + +L+EEN
Sbjct: 1274 LLNNS----KLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR---- 1325
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
L+ + + Q+ LE+ MES+ + ++ Q +++L RQ+ + L +
Sbjct: 1326 ---------HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK-EKLEE 1375
Query: 1601 QYLSENEQW-----QQKLTSVTLEMESKLAAEK--KQTEQLSLELEVAR-------LQLQ 1646
+ + + + + +++ +TL+M + ++K + Q SL L R LQL
Sbjct: 1376 KIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLP 1435
Query: 1647 GLDLSSRSLLG 1657
D S +G
Sbjct: 1436 HQDSQDSSSVG 1446
Score = 110 bits (275), Expect = 2e-23
Identities = 280/1402 (19%), Positives = 561/1402 (40%), Gaps = 213/1402 (15%)
Query: 850 QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQ--EDTSAHQNVVAETLSALE 907
QK+ E + +I+G ++ + A H V + + LQ E T Q + L +
Sbjct: 136 QKKEEFIERIQG-LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
Query: 908 NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL-----------LSETLSLEKK 956
K L D+ E+ E + H L + Q + LS+E
Sbjct: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
Query: 957 EMSSIISLNKREIEELTQENGTLK------EINAS-LNQEKMNLIQKSESFANYIDEREK 1009
+ + I ++E+EE T++ K EI L QE MNL+ + S Y DE +
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
Query: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQK---YKAAQEKNSKLECLLNECTSLCEN 1066
+EK + + + E + Y++ YKA E+ + +L E ++ E+
Sbjct: 315 L---------REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAG 1126
+LE + K H+ E+ N L +L + EM + + K E
Sbjct: 366 ---QLEGTRARSDKLHE--------LEKENLQLKAKLHDM------EMERDMDRKKIEE- 407
Query: 1127 GLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186
L +E MTL+ Q + E L E EQ+ + E + + + V E S R
Sbjct: 408 -LMEENMTLEMAQKQSMDESLHLGWELEQISRTS----ELSEAPQKSLGHEVNELTSSR- 461
Query: 1187 QCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL- 1245
+ LE++ SL +L + K+ + EKE + L +++ + ++
Sbjct: 462 ------LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 1246 -ETSNLQDMQSQEISGLKD---CEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301
E +LQ+ Q+ +K+ E E + ++ + +N HL ++ +++ + +
Sbjct: 516 QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV-SSLRQRS 574
Query: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361
++ + EK + L++S E + K+ E ++ E++ + GE
Sbjct: 575 QISAEARVKDIEKENKI--LHESIKETSSKLSKIEFEKRQIKKELEHYKEK-----GERA 627
Query: 1362 EDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE-LQEKFLSLQSEHKI 1420
E++ NE H L++ N +++ ++ E L+++ L+ E++
Sbjct: 628 EELE--------NELHH-----LEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 1421 LH---DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLS 1477
L D ++ ++ L+ L ENL L N+ + + +K QL LE L
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELE 731
Query: 1478 SSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLT 1537
S L L +A ++T + EV L EN
Sbjct: 732 SEKEQLKKGLELL------KASFKKTERL------------------EVSYQGLDIEN-- 765
Query: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597
+ L+ E + +++LE +++ M+N+ +Q+ + L + L+
Sbjct: 766 ------------QRLQKTLENSNKKIQQLESELQDLE-MENQTLQKNLEELKISSKRLEQ 812
Query: 1598 LRKQYLS-ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE---LEVARLQLQGLDLSSR 1653
L K+ S E E Q + LE E+K ++ + + +LE +++ L+ + LS
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 1654 SLLGIDTEDAIQGR---NESCDISKEHTSE-TTERTPKHDVHQICDKDAQQDLNLDIEKI 1709
+GI E ++ + E+ ++ K T + T T + D+ + +K Q +N D+EK+
Sbjct: 873 --IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDLEKL 928
Query: 1710 T---ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ 1766
T E + EQS D + E K + + + E+ +
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI---------------KE 973
Query: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826
E I L+ R++E++N N +L ++ + E+L Q+ + M + I
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR----------QDEERMVQSSPPI 1023
Query: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886
E + ++E+ + + +L ++ R+ E N+ L+ A+K + + +
Sbjct: 1024 SGED--NKWERESQETTREL-------LKVKDRLIEVERNNATLQ--AEKQALKTQLKQL 1072
Query: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVI 1946
N++ + + L ++ + ++ + +++ + L+ + + ++ L N+N Q +I
Sbjct: 1073 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM--NQNAQLLI 1130
Query: 1947 --VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC--- 2001
LE E V ER L+ D++ K L+ L E+ + + L S
Sbjct: 1131 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1190
Query: 2002 IQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
++V +++++ L + +L K QEK+ K+ + ++ +L + +L
Sbjct: 1191 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1250
Query: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
N L+KE+E LQ + N+ L + +E+ S +E+ QL
Sbjct: 1251 NHTYSQLLKETEVLQT-------DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1303
Query: 2122 EKLRVRIEADEKKQLHIAEKLK-ERERENDSLKDKVENLERE----LQMSEENQELVILD 2176
KL Q + +LK E EN L D+++ L + L+ + E+++L ++
Sbjct: 1304 TKL--------NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1355
Query: 2177 AENSKAEVETLKTQIEEMARSL 2198
++ L+ Q E++ +
Sbjct: 1356 QRQYIDKLNELRRQKEKLEEKI 1377
Score = 97.1 bits (240), Expect = 2e-19
Identities = 186/857 (21%), Positives = 339/857 (39%), Gaps = 138/857 (16%)
Query: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
A K+ +L+ + +L+ EK+Q + L+ L+A+ +K E + L ENQRL +
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKK----TERLEVSYQGLDIENQRLQKT 771
Query: 76 CESLEKTKQKISHELQVKES-----QVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
E+ K Q++ ELQ E Q N +E +++S K++E+LE+E K + E + ++
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISS--KRLEQLEKENKSLEQETSQLEK 829
Query: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK------YNKEVEERKRLEAE 184
+ + +I T L + G+ ++ K Y + K LE E
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
K L K+A+ + D+ + + + EK L+ ++ + ++
Sbjct: 890 NKEL-VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----LTHELEKIGLNKE---R 941
Query: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
EQ SR L K ++ LK + KI LE RL+
Sbjct: 942 LLHDEQSTDDSRYKLLESKLEST---------------LKKSLEIKEEKIAALEARLE-- 984
Query: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
N Q+L+ +L+ K + + L + +DE + Q+S +
Sbjct: 985 -----ESTNYNQQLRQELKTVK----KNYEALKQRQDE-----ERMVQSSPPISG----- 1025
Query: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
ED +R++ E+ R L+ K + L +R+ TL E K L +
Sbjct: 1026 ----EDNKWERESQETTRELLKVK---------DRLIEVERNNATLQAE----KQALKTQ 1068
Query: 425 LQQAKNMHNVLQAELDKL--TSVKQQLENNLEEFKQKLCRAEQAFQASQ----------- 471
L+Q + +N LQA++ L +V Q +N + + + E + SQ
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 472 -IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE--MKA 528
I+++ L E + KE LKS + ++ H + EL + +Q ++ +K+
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYESLISKHGTLKS 1186
Query: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD--LLKKREHHIEQLND 586
+ + E RDL+++ NQ L K K + DLEK Q+ LL+ + H
Sbjct: 1187 AHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEKMLKVEQEKMLLENKNH------- 1233
Query: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
E K L + Y +L +E + + LL + E+ L+++ +
Sbjct: 1234 --ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
Query: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
L+ + I S + N + L + NL E R+L + + + ++ T L+Q
Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQN 1345
Query: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----- 761
E D H ++ Q ++ +L + + L +IMD+ + Y
Sbjct: 1346 MESKDLFH--------VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWIT 1397
Query: 762 -SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
+R L+KSK N + Q+SL + F + + S LE Q
Sbjct: 1398 LKMRKLIKSKKD---INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1454
Query: 821 S--PKNSAILQNRVDSL 835
+ K S+ + + V S+
Sbjct: 1455 TLGTKKSSTMNDLVQSM 1471
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 202 bits (515), Expect = 3e-51
Identities = 279/1308 (21%), Positives = 575/1308 (43%), Gaps = 188/1308 (14%)
Query: 1644 QLQGLDLSSRSLLGIDTEDAIQGRN--------ESCDISKEHTSETTERTPKHDVHQICD 1695
++QGLD +++ + ++ + E D+S+E + H I +
Sbjct: 144 RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDE 203
Query: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
+D + +++ + + P S QSP + PG +T+ EL+ +
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSA-QSPCGS---PGMKRTESRQHLSVELADAKAK 259
Query: 1756 AL--------VPMDFLGNQEDIHNLQLRVKETSNENLRLLH-------------VIEDRD 1794
L ++++ +++ +K EN+ LL + ++
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
Query: 1795 RKVESLLNEMKELDSKLH------------LQEVQLMTKIEACIELEKIVG--------- 1833
+V+ L +E+ +LH ++ Q++ + + +E +++ G
Sbjct: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE-DQLEGTRARSDKLH 378
Query: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
EL+KEN L KL + +++E N LEM A K S ++ ++ W
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM-AQKQSMDE------SLHLGW 431
Query: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
+ + +ELS + + S+ HE E+ + L LE +N++ K + EEL
Sbjct: 432 ELEQISRTSELSE--APQKSLGHEVN------ELTSSRLLKLEMENQSLTKTV----EEL 479
Query: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
+ + G + K +LS+K++ E+ + +C +++ +KEK
Sbjct: 480 RTTV---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 2014 ELLQTLSS-------DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
+L +T+ + + L ++ HL + + SL + SQ + E ++ + KE +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA------EARVKDIEKENK 590
Query: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIE 2122
+L + + ++LS+ ++EK + K LE EKGE A L + ++E L++ I
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 2123 KLRV---RIEADEKKQLHIAEKLKERERENDSLKD---KVENLERE-LQMSEENQELVIL 2175
L++ +IEA E++ + + ++ ++ DS K+ ++E+LE+E Q+ EEN EL
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL--- 706
Query: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
+ VE+LK +MA+ +L+ L SEKE L K ++ + + ++L S
Sbjct: 707 -----RRNVESLKCASMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 2236 FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
++ L E ++ + + E S ++ L+++L++L L + E +K + + L+ +E+
Sbjct: 758 YQGLDIENQRLQKTL-ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-LEK 815
Query: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
E++ S+E+ ++LE D+K+ + ++ K A++ +E E ++I +E+
Sbjct: 816 ENK---SLEQETSQLEKDKKQ---LEKENKRLRQQAEIKDTTLE--ENNVKIGNLEKENK 867
Query: 2356 ALEAENS--KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
L E K LK + + ++ +D+ T+ + +E+L +E K Q+ ++LE
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS 2473
+ E I KE+ + ++ + ++L+++L+ + L E + K L +
Sbjct: 928 LTHELEKIGLNKER-LLHDEQSTDDRYKLLESKLE------STLKKSLEIKEEKIAALEA 980
Query: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD 2533
++E QL Q L K NY L+ Q QD
Sbjct: 981 RLEESTNYNQQLRQELKTVKKNYEALK-----------------------------QRQD 1011
Query: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
+E++V + GE W+ ++ E ++++ ++ ++ NA+LQ + L++ K L
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1071
Query: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
E + + ++ + + + T LQ + ++ + + L + + N+ A QLL
Sbjct: 1072 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA---QLL 1128
Query: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
+++ S +++ + + E +LK D + KD + E + +EY+ + KH
Sbjct: 1129 IQQ-SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI----SKH-GT 1182
Query: 2714 LLDTNKQYEVEIQ----TYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
L +K EVE + Y + L K + +K +LK +E++ K + E
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK----MLKVEQEKMLLENKNHETVAAE 1238
Query: 2770 LKKT--KMDNLKYV-NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
KK + D L + +QL KE E Q K L + E+ L+ E S+L +E+
Sbjct: 1239 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL---KEQY 1295
Query: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
+ + TK++ + +LK LEE+ + LD+ +L++ + L
Sbjct: 1296 QQLDITSTKLNNQCELLSQLKGNLEEENR---HLLDQIQTLMLQNRTL 1340
Score = 186 bits (472), Expect = 3e-46
Identities = 251/1082 (23%), Positives = 479/1082 (44%), Gaps = 150/1082 (13%)
Query: 1852 DHQE-LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVENELSRI 1907
+H E +++ E +GL+ HA S++ G K +S + D + ++ R+
Sbjct: 206 EHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
Query: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
R E + L + +LE ++ E L+++N N LS S R R EL
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL----------LSDARSAR-MYRDEL 312
Query: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA---EVKEKTELLQTLSSDVS 2024
D + +K +D+L ++ S E LH I+ +A E+KE ++L + +
Sbjct: 313 DALREKAVRVDKLESEV--------SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
+ L+ +KL LEK++ L ++E + K+ E L++E+ +L+ +S
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 2085 EKLNVSKALE-----AALVEKGEFAL----------RLSSTQEEVHQLRRGIEKLRVRIE 2129
E L++ LE + L E + +L RL + E L + +E+LR ++
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
+ E A K+ + E+EN L KVE LE E+ +++ + + +N ++ K
Sbjct: 485 SVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQ----NCQNLSKDLMKEKA 536
Query: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Q+E+ T+ + +EN +QI+ + + L++ +SS + + AE +
Sbjct: 537 QLEK-------------TIETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEAR 581
Query: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
+K+ ++ + K L+E++ K T L E+ Q++ +E + +
Sbjct: 582 VKD--------IEKENKILHESI----------KETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE-IARTNQEHAALEAENSKGEVET 2368
E E+ + +L E +LL+ ++ NL+ E I QE++ LE EN K + +T
Sbjct: 624 GERAEELE----NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-KT 678
Query: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
L + + +T L LE + + ++ENL E + + +++ EN +E E E
Sbjct: 679 LDS-FKNLTFQLESLEKE--NSQLDEENLELRRNVESLKCASMKMAQLQLEN--KELESE 733
Query: 2429 KVQMKE------KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
K Q+K+ S E L+ + L+ L E K Q L S+++ LE+E
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
L + L+E K + + ++++E + LE++ ++ + K Q++ + + + + +
Sbjct: 794 QTLQKNLEELKIS--------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL-ENELELTK 2601
++ K+ LE N+ KI L+ +N +L + + + S L E E E +
Sbjct: 846 EI-------KDTTLEENNV------KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
+ K + ++ +T +E +L E + Q +L E+L+ E ++ + LL + +S+
Sbjct: 893 LVKRATIDIKTLVTLRE-DLVSEKLKTQQMNNDL-EKLTHELEKIGLNKERLLHDEQSTD 950
Query: 2662 DQLKELTLE-NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LLDT 2717
D+ K L + S LKKSL+ E+IA + RL E+ +Q L L
Sbjct: 951 DRYKLLESKLESTLKKSLEIKE-----------EKIAALEARLEESTNYNQQLRQELKTV 999
Query: 2718 NKQYEVEIQTY-REKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE------EL 2770
K YE Q E++ +S + + + + S+E LK +++E L
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWE--RESQETTRELLKVKDRLIEVERNNATL 1057
Query: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT-G 2829
+ K + QL+ +N Q ++ L + L+E+ LQ + ++LQ +
Sbjct: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
Query: 2830 TVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLC 2889
T + + +L + L+ E KE ++ Y SL+ HEKLE E ++ L
Sbjct: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
Query: 2890 SQ 2891
S+
Sbjct: 1178 SK 1179
Score = 158 bits (399), Expect = 9e-38
Identities = 264/1261 (20%), Positives = 540/1261 (42%), Gaps = 180/1261 (14%)
Query: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Q L +L K + ++ + +L+ L KQ++E + E L++EN L+ S
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
+ ++ ++E V +++KLE E+ R K L D+
Sbjct: 307 MYRDELD---ALREKAV------------RVDKLESEVSRYKERLH---------DI--- 339
Query: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK-------KA 193
++Y ++ E+LKE +E + LE +++ +A+ +
Sbjct: 340 ----------------EFYK-ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
+A ++ ++ R + +E ++ + + E E
Sbjct: 383 ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD------ESLHLGWELEQI 436
Query: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
S L + + + +S LL +L+ +NQ L + EL + ++G +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLL-KLEMENQSLTKTVEELRTTVD----SVEGNAS 491
Query: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
K L++EK L +K ++L +E+V+ L ++ +L + +
Sbjct: 492 KI----LKMEKENQRLSKKVEIL---ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
R+N+E LEQ E E Q S +QRS I +AR+ ++ K +H
Sbjct: 545 LRENSERQIKILEQ---ENEHLNQTVSSLRQRS-------QISAEARVKDIEKENKILHE 594
Query: 434 VLQAELDKLTSV---KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
++ KL+ + K+Q++ LE +K+K RAE EL + ++KEN L
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-----------ELENELHHLEKENEL 643
Query: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
L+ +++ +L+ + I + L Q + E++ +N + L D + + Q S
Sbjct: 644 LQ-------KKITNLKITCEKI-EALEQENS---ELERENRKLKKTL-DSFKNLTFQLES 691
Query: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
L E +L +LE +R+ + LK + QL + + E E + L LEL K ++
Sbjct: 692 LEKENSQLDEENLELRRNV--ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
+ + + + EN++L + EN KI LE+ L+ ++++ +TL+
Sbjct: 750 KTERLEVSYQGLDIENQRL----QKTLENSNKKIQQLESELQDLEMEN-------QTLQK 798
Query: 671 DRENLSVEIRNLHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
+ E L + + L + ++KS+E ET +L + Q + E + Q EI++ L+ + +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV- 857
Query: 730 GQVEDLEHKLQLLSNEI-MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
++ +LE + + LS EI + K+ C + E E+ ++L+K + T + L++
Sbjct: 858 -KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATIDIKTLVTLREDLVSEK 915
Query: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
+ ++ + + E + L ++ + +R LE LES + + +
Sbjct: 916 LKTQQMNN------DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
Query: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
+++ E++ ++ +EE+ +Q+ Q V + + + + Q++ Q+ + +S
Sbjct: 970 IKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGE 1025
Query: 907 ENK-EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
+NK E+E Q ++ + + E++++N L+ + L+ + L + + + I
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Query: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
+R+ L ++N TL+ NA L E L +S S N + + + + S + + ++
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN---QNAQLLIQQSSLENENESVI 1142
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+R EDL Y + + + KLE L S E+ ++ LK A H+
Sbjct: 1143 KER--------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA----HKNL 1190
Query: 1086 LTKLAFAEERNQNLML---ELETVQQALRSE----MTDNQNNSKSEAGGLKQEIMTLKEE 1138
+ E+R L+ +LE +++ L+ E + +N+N+ A E L E
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA-----EYKKLCGE 1245
Query: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ-MDLE 1197
+++ + LL+E E V++T H +NL+S + +++ E K Q L+
Sbjct: 1246 NDRLNHTYSQLLKETE----VLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1299
Query: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
+ L++ L QL+ L E+E L ++QT+ T Q+M+S++
Sbjct: 1300 ITSTKLNNQCELLSQLKGNL----------EEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349
Query: 1258 I 1258
+
Sbjct: 1350 L 1350
Score = 153 bits (386), Expect = 3e-36
Identities = 222/981 (22%), Positives = 445/981 (45%), Gaps = 151/981 (15%)
Query: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
E + ++ ER+ L S + K E Q L ++ I+ E++
Sbjct: 209 ETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELE 268
Query: 2011 EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
EKTE L ++ ++ + LQ++ +L D+++ + + EL+ +EK + V
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL-----REKAVRVD 323
Query: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
+ ES +R E ++ + KA L E + L + E+ QL G ++
Sbjct: 324 KLESEVSRYKERLHD-IEFYKARVEELKEDNQVLLETKTMLED--QLE-GTRARSDKLHE 379
Query: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERE---LQMSEENQ-----------ELVILD 2176
EK+ L + KL + E E D + K+E L E L+M+++ E +
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 2177 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
+E S+A ++L ++ E+ S L+ L E ++LTK ++E + + ++ S
Sbjct: 440 SELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEGNAS-- 491
Query: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296
K L EKE + K VE+L+N++ + +++ ++ + ++E+
Sbjct: 492 KILKMEKENQRLSKK------VEILENEIVQ----------EKQSLQNCQNLSKDLMKEK 535
Query: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
QL +IE LR E +Q+ +L+Q E+EH L V +L + +I+
Sbjct: 536 AQLEKTIETLRENSE----RQIKILEQ--ENEH----LNQTVSSLRQRSQIS-------- 577
Query: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
++ V+ ++ + + + +S++ + I EK + EL+ +E+ E + +
Sbjct: 578 -----AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 2417 SFENILQEKE--QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
++ +E E Q+K+ + + +E L+ + EL L ++ K NL+ Q
Sbjct: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK----NLTFQ 688
Query: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR----LKNQ 2530
+E LE E +QL + E + N L+ + + Q + K+ LE + E++ + LK
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKAS 747
Query: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQSKNASLQDTLEVLQSS 2589
+ E+L ++ E+Q ++ LE N ++ LE ++Q L+ +N +LQ LE L+ S
Sbjct: 748 FKKTERLEVSYQGLDIENQRL-QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
K LE +L++E + Q+T++L+++ K +L E
Sbjct: 807 SKRLE-------------------------QLEKENKSLEQETSQLEKD----KKQLEKE 837
Query: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK-VREEIAEYQ---LRLHE 2705
+ L ++ ++K+ TLE + +K +EKE K + +EI Y+ +RL E
Sbjct: 838 NKRLRQQA-----EIKDTTLEENNVKIG-------NLEKENKTLSKEIGIYKESCVRLKE 885
Query: 2706 AEKKHQALLLDTNKQYEVEIQTY---REKLTSKEECLSSQKLEIDLLKSS---------K 2753
EK+++ L+ K+ ++I+T RE L S++ L +Q++ DL K + K
Sbjct: 886 LEKENKELV----KRATIDIKTLVTLREDLVSEK--LKTQQMNNDLEKLTHELEKIGLNK 939
Query: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA-QGKMKLLIKSCKQLEEEKEIL 2812
E L + ++T + L+ LK ++K+E A + +++ +QL +E + +
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Query: 2813 QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHE 2872
+K L+ Q++++ M ++ E + + +E T+E + D+ + ++
Sbjct: 1000 KKNYEALKQRQDEER----MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055
Query: 2873 KLEKAKEMLETQVAHLCSQQS 2893
L+ K+ L+TQ+ L +Q +
Sbjct: 1056 TLQAEKQALKTQLKQLETQNN 1076
Score = 153 bits (386), Expect = 3e-36
Identities = 243/1190 (20%), Positives = 510/1190 (42%), Gaps = 152/1190 (12%)
Query: 327 VELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
VEL + + + + R EL T Q + +E +LK+L ++ +A SAR +
Sbjct: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
Query: 387 QKIKEKEK-----EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
+ +EK + + E+SR + ++ KAR+ ++ K + VL L+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEF----YKARV----EELKEDNQVL---LET 359
Query: 442 LTSVKQQLE------NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
T ++ QLE + L E +++ + + +++ + R+ +EE+ +EN L+
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
+Q E HL EL+ I + S+ ++ ++ T R L+ ++ Q + T+E+
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEA-PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
L+ V +E K+ K EKE++ L +E+ + E ++E+
Sbjct: 479 LRTTVDSVEGNAS------------------KILKMEKENQRLSKKVEILENEI--VQEK 518
Query: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
++L +C + + + + EK +++ + E +K + ++ N+ V +L R +
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQI 576
Query: 676 SVEIR----NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
S E R N + +S++ + KL+ +E +++ + +H KE + +L +
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENE 633
Query: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
+ LE + +LL +I + + + A L+ +++ L + L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEA--------LEQENSELERENRKLKKTL------ 679
Query: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM---NSD 848
SF N+ + S+ E S Q + + L+ V+SL+ + Q+ N +
Sbjct: 680 ---DSFKNLTFQLESLEKENS-------QLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
L+ + E+L + ++ + K E++ S+ + +QR+ K E+++ + L L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
E + + LQ ++++ +++L+K N LE +L+ + L E K + +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
+EE + G L++ N +L++E + + ++S + E EK EL + + L+
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKE-IGIYKES---CVRLKELEKENKELVKRATIDIKTLV 905
Query: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL-------EQLKEAFA 1079
EDL + Q+ N+ LE L +E + N++ L ++ K +
Sbjct: 906 -------TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 1080 KEHQEFLTKLAFAEERNQNLMLELE---TVQQALRSEMTDNQNN-----SKSEAGGLKQE 1131
K L EE+ L LE Q LR E+ + N + + + Q
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 1132 IMTLKEEQNKMQKE----VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQ 1187
+ E NK ++E +LL+ ++L++V + Q E + ++ +K+ E++ N
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ-AEKQALKTQLKQLETQNNN 1077
Query: 1188 CNF------KPQMDLEVKEISLDSYNAQLVQLE----------AMLRNKELKLQES--EK 1229
+ + L+ + +L + NA+L Q+E M +N +L +Q+S E
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKL-QVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 1230 EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHL 1289
E E + E + ++ L S ++D + E+ L + + E IS L ++ +
Sbjct: 1137 ENESVIKEREDLK-SLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 1290 QCSLQTTMNKL----NELEKICEILQAEKYELVTELNDSRSECITATRKMAEE------- 1338
L+ N+L +LE + ++L+ E+ +++ E N + +K+ E
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGENDRLNHT 1252
Query: 1339 VGKLLNEVKILNDD-----SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
+LL E ++L D S L + +L + EF + + + + +N E L
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
Query: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-ELQTYVDSL 1442
+ ++ L ++ +L +++ L +Q+ + E + Y+D L
Sbjct: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Score = 147 bits (371), Expect = 2e-34
Identities = 244/1167 (20%), Positives = 492/1167 (42%), Gaps = 217/1167 (18%)
Query: 1539 KETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE-QLLSSERQELDC 1597
K T S VE ++ ++ R+ ++LEEK E Q + +E++++E +L +++ ++
Sbjct: 241 KRTESRQHLSVELADAKAKI-RRLRQELEEKTE-QLLDCKQELEQMEIELKRLQQENMNL 298
Query: 1598 LR-----KQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
L + Y E + ++K V KL +E + ++ ++E + +++ L +
Sbjct: 299 LSDARSARMYRDELDALREKAVRV-----DKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 1653 RSLLGIDT--EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT 1710
+ LL T ED ++G D K H E K +H D + + ++D +KI
Sbjct: 354 QVLLETKTMLEDQLEGTRARSD--KLHELEKENLQLKAKLH-----DMEMERDMDRKKIE 406
Query: 1711 ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ-EDI 1769
E T E + +QS D + E + ++S + + P LG++ ++
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWE---------LEQISRTSELSEAPQKSLGHEVNEL 457
Query: 1770 HNLQLRVKETSNENLR--------LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTK 1821
+ +L E N++L + +E K+ + E + L K+ + E +++ +
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 1822 IEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET-SEGLN---SDLEMHADKS 1877
++ + + +L KE + L + +E + + ++ +E +E LN S L + S
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 1878 SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEAD---LEVVQTEKLC 1934
+ + D + K N E + ++LS+I EK I+ E + + E ++ E
Sbjct: 578 AEARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHH 636
Query: 1935 LEKDNENKQKVIV----------CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984
LEK+NE QK I LE+E S + E +L+ LD+ T L+ L ++
Sbjct: 637 LEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
Query: 1985 KE---------------------------KTQELESHQSECLHCIQVAEAEVKEKTEL-- 2015
+ + +ELES + + +++ +A K+ L
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
Query: 2016 ----------------------LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCE 2053
+Q L S++ +L + LQ+ L+ L+ S+ L + E
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 2054 ---LENQIAQLNKEKELLVKESESL--QARLSESDYEKLNV--------SKALEAALVEK 2100
LE + +QL K+K+ L KE++ L QA + ++ E+ NV +K L +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 2101 GEFALRLSSTQEEVHQL-RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2159
E +RL ++E +L +R ++ + E ++EKLK ++ ND +E L
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDL---VSEKLKTQQMNND-----LEKL 928
Query: 2160 ERELQMSEENQELVILDAENSKAEVETLKTQIEE-MARSLKVFELDLVTLRSEKENLTKQ 2218
EL+ N+E ++ D +++ + L++++E + +SL++ E + L + E T
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 2219 IQEKQGQLSELDKLLSSFKSLLEEKEQAEIQI----------KEESKTAVEMLQ--NQLK 2266
Q+ + +L + K + K +E+ + +E +T E+L+ ++L
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 2267 ELNEAVAALCGDQEIMKATEQSLDPP-----------------IEEEH----------QL 2299
E+ A L +++ +K + L+ ++E++ Q+
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 2300 RNSIEKLRARLEADEKKQLCVLQQLKESEHHADL-----LKGRVENLERELEIARTNQEH 2354
NS ++ ++ QL + Q E+E+ + + LK ++L ++ E E
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1168
Query: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLE---LDVVTIRSEKENLTNELQKEQERI--- 2408
A E E+ + TLK+ + + R LE ++ + + E+L L+ EQE++
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228
Query: 2409 ---------------SELEIINSSFENILQEKEQEKVQMKEKSS---------TAMEMLQ 2444
E + +N ++ +L+E E + K S T +E
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 2445 TQLKE-----------LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
++LKE LN + L + + + ++L Q++ L L+ LL+ E+K
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
+ + V Q + E+ K+KLE+K
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Score = 141 bits (355), Expect = 1e-32
Identities = 247/1194 (20%), Positives = 493/1194 (41%), Gaps = 179/1194 (14%)
Query: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL 604
++Q S+ L K + L ++ + + L + +EQ+ +L + ++E+ LLS
Sbjct: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
Query: 605 KKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER 664
+ +EL + E + ++ESE + +++ +E Y R
Sbjct: 305 ARMYRDELDALR--------EKAVRVDKLESEVSRYKERLHDIEF-----------YKAR 345
Query: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
V L+ D + V +ET+ + +L+ SD+ H+ E EN+ LK
Sbjct: 346 VEELKEDNQ-----------------VLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 725 TSQLTGQVE-DLEHKL------QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN 777
++E D++ K + ++ E+ K + LH +E L + ++ + S
Sbjct: 389 AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE-LEQISRTSELS---- 443
Query: 778 EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD----------QSPKNSAI 827
E Q+S L + + E S+ E R D + K +
Sbjct: 444 EAPQKS-LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
Query: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
L +V+ LE + +KQ + Q ++L++ K ++E+ + + E S+R K
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI--------ETLRENSERQIK 554
Query: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
+ E + H N +T+S+L + + + +A +++++K N +L +S+KE
Sbjct: 555 ILEQENEHLN---QTVSSLRQRSQ---------ISAEARVKDIEKENKILHESIKETSSK 602
Query: 948 SETLSLEKKEMSSIISLNKRE---IEELTQENGTLKEINASLNQEKMNL------IQKSE 998
+ EK+++ + K + EEL E L++ N L ++ NL I+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYED------LSQKYKAAQEKNSK 1052
+ ++ + + + D +K L +E E+ + K A K ++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 1053 LECLLNECTSLCENRKNELEQLKEAFAK-------------EHQEFLTKLAFAEERNQNL 1099
L+ E S E K LE LK +F K E+Q L + ++ Q L
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 1100 MLELETVQ---QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
EL+ ++ Q L+ + + + +SK L++E +L++E ++++K+ L +EN++L
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 1157 MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN--------- 1207
+ + K + I N KE ++ + + + +KE+ ++
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEID 1267
LV L L +++LK Q+ + E L HEL+ I + E + + + L + +++
Sbjct: 902 KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE 961
Query: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSE 1327
+ K L + A L+ L+ + N +L + + ++ + YE + + D
Sbjct: 962 STLK-----KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK-KNYEALKQRQD-EER 1014
Query: 1328 CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387
+ ++ ++ E K E + + + L+E + + L L+
Sbjct: 1015 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1074
Query: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN- 1446
N+ +Q LQ + +SLQ ++ L Q+ ++ + S L + SL +N
Sbjct: 1075 NN---------NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125
Query: 1447 --LVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGD--SSFYRALLEQ 1502
L+ ++L N ++KE + + SL S + D L L + +S Y +L+ +
Sbjct: 1126 QLLIQQSSLENENESVIKERE------DLKSLYDSLIKDHEKLELLHERQASEYESLISK 1179
Query: 1503 TGDM-SLLSNLEGAVSANQCSVDEVFCSSLQEENLTR---------------KETPSAPA 1546
G + S NLE + +++ Q E+L + ET +A
Sbjct: 1180 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1239
Query: 1547 KGV-EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE 1605
K + E + L Y Q L++ E + + + L+ LL++ + E L ++
Sbjct: 1240 KKLCGENDRLNHTYSQLLKETE--------VLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1291
Query: 1606 NEQWQQ-KLTSVTLEMESKLAAEKKQTEQLSLELEVARL--QLQGLDLSSRSLL 1656
EQ+QQ +TS L + +L ++ K +LE E L Q+Q L L +R+LL
Sbjct: 1292 KEQYQQLDITSTKLNNQCELLSQLKG----NLEEENRHLLDQIQTLMLQNRTLL 1341
Score = 137 bits (344), Expect = 2e-31
Identities = 203/953 (21%), Positives = 410/953 (43%), Gaps = 127/953 (13%)
Query: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--------NEKTEGTNLK 66
R +K++ LE ++ + K+ Q Q +L L K+K ++E N + + L+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 67 RENQRLMEICESLEKTKQKISHELQVK--ESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
+EN+ L + SL + Q IS E +VK E + + ++ K+E E ++ K E
Sbjct: 558 QENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 125 LERSQQAAQSADVSLNPCN--------TPQKIFTTPLTPSQYYS----GSKYEDLKEKYN 172
LE ++ + A+ N + +KI +T + + S+ E K
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 173 KEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
K ++ K L ++++L+ K + L + + R +S+ Q + L S
Sbjct: 677 KTLDSFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ----LKAQNQ 288
++ + + F + + S L I + + +++ L+ L+ +NQ
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 289 ELRNKINELEL---RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
L+ + EL++ RL+ EKE K ++ QLEK K +L EKE + + E+
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKS----LEQETSQLEKDKKQL-EKENKRLRQQAEIKD 849
Query: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
TT + + + K LE++ K L++++ +++ ++KE EKE +E + R
Sbjct: 850 TTLE--ENNVKIGNLEKENKTLSKEIGIYKESCV--------RLKELEKENKELVKRATI 899
Query: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
+TL + ++ L E + + M+N +L+KLT +++ N K++L EQ
Sbjct: 900 DIKTL----VTLREDLVSEKLKTQQMNN----DLEKLTHELEKIGLN----KERLLHDEQ 947
Query: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
+ + R + E K E+ L KS E K ++ LEA L+ + N +Q +E
Sbjct: 948 S--------TDDRYKLLESKLESTLKKS-LEIKEEKIAALEARLE---ESTNYNQQLRQE 995
Query: 526 MKAKNTSQETML-RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
+K + E + R +E++ Q ++ E K + ++ +++LLK +
Sbjct: 996 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE----RESQETTRELLK--------V 1043
Query: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ---MESEKENLQ 641
D+L + E+ + L + + K + ++L+ ++N L Q ++ + +LQ
Sbjct: 1044 KDRLIEVERNNATLQAEKQALKTQLKQLE----------TQNNNLQAQILALQRQTVSLQ 1093
Query: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
+ L+T Q+++ N + +L L ++ +L N +S E E K Y
Sbjct: 1094 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153
Query: 702 EL---QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
L +K E ++ E E++ K G ++ L++ ++ D+
Sbjct: 1154 SLIKDHEKLELLHERQASEYESLISKH----GTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
Query: 759 EYESLRDLLK-SKDASLVTNEDHQRSLLAFD----QQPAMHHSFANIIGEQGSMPSERSE 813
+ E L +LK ++ L+ N++H+ + + ++H+++ ++ E + ++
Sbjct: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
Query: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
+ + S L+ L+ + ++ L QCE L Q+KG +EE E
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE-----ENR 1324
Query: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE-----KELQLLNDKVE 921
H +T LQ T QN+ ++ L +E ++ EL+ +K+E
Sbjct: 1325 HLLDQIQTLM----LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1373
Score = 134 bits (337), Expect = 1e-30
Identities = 302/1532 (19%), Positives = 626/1532 (40%), Gaps = 244/1532 (15%)
Query: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939
E +RI L DT A V A N+E L + E+ ++ + + +E
Sbjct: 140 EFIERIQGLDFDTKAA--VAAHIQEVTHNQENVFDL-------QWMEVTDMSQED--IEP 188
Query: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES 999
LK + L + L E+ E S I E + L + M + +
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQH 248
Query: 1000 FANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE 1059
+ + + + I L + +++ LL +E E + + K Q++N L L++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNL---LSD 301
Query: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
S ++EL+ L+E + + KL R + + ++E + + DNQ
Sbjct: 302 ARS-ARMYRDELDALREKAVR-----VDKLESEVSRYKERLHDIEFYKARVEELKEDNQ- 354
Query: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
+ E T+ E+Q + + +D L E E+ +K K +E + R ++
Sbjct: 355 --------VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 1180 ERESERNQCNFKPQMDLEV-KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
E E M LE+ ++ S+D +LE + R EL SE ++ L HE+
Sbjct: 407 ELMEEN--------MTLEMAQKQSMDESLHLGWELEQISRTSEL----SEAPQKSLGHEV 454
Query: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
+L +S L ++ + S K E EL T+ D+ S M
Sbjct: 455 N----ELTSSRLLKLEMENQSLTKTVE------------ELRTTV-DSVEGNASKILKME 497
Query: 1299 KLNE-LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLH 1357
K N+ L K EIL+ E + + S C ++ + +E +L ++ L +
Sbjct: 498 KENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE------ 547
Query: 1358 GELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417
N + + + L++ N + + T+S + + + + ++ E
Sbjct: 548 ----------------NSERQIKI--LEQENEHLNQTVSSLRQRSQISA-EARVKDIEKE 588
Query: 1418 HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ--GDLVKEMQLGLEEGLVPS 1475
+KILH+ + SSK+S+++ +K E L +++ G+ +E++ L
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKE-------LEHYKEKGERAEELENELHH----- 636
Query: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDM--SLLSNLEGAVSANQCSVDEVFCSSLQE 1533
LE+ ++ ++NL+ ++ + E S L+
Sbjct: 637 ------------------------LEKENELLQKKITNLK--ITCEKIEALEQENSELER 670
Query: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
EN K+T + +LESL EK +++ + + + ++ L+ S +
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESL--------EKENSQLDEENLELRRNVESLK-CASMKMA 721
Query: 1594 ELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS-----LELEVARLQLQGL 1648
+L K+ SE EQ ++ L L A K+TE+L L++E RLQ + L
Sbjct: 722 QLQLENKELESEKEQLKKGL--------ELLKASFKKTERLEVSYQGLDIENQRLQ-KTL 772
Query: 1649 DLSSRSLLGIDTE--------DAIQGRNESCDISKEHTS--ETTERTPKHDVHQICDKDA 1698
+ S++ + +++E +Q E IS + E ++ + + Q+ +KD
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL-EKDK 831
Query: 1699 QQDLNLDIEKITETGAVKPTG-ECSGEQSPDTNYEPPGEDKTQG--SSECISELSFSGPN 1755
+Q L + +++ + +K T E + + + E K G C+ N
Sbjct: 832 KQ-LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 1756 ------ALVPMDFLGN-QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808
A + + L +ED+ + +L+ ++ +N+ +L H +E E LL++ + D
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 1809 SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNS 1868
+ L E +L + ++ +E+++ ++ + L +LE + +Q+L Q ++T +
Sbjct: 951 DRYKLLESKLESTLKKSLEIKE------EKIAALEARLEESTNYNQQLRQELKTVKKNYE 1004
Query: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
L+ D+ ++ ++ W+ + EL +++ +E L+A+ + +
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
Query: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
+T+ LE N N Q I+ L+ + +V E+N T L + K++ +
Sbjct: 1065 KTQLKQLETQNNNLQAQILALQRQ-TVSLQEQN-------------TTLQTQNAKLQVEN 1110
Query: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
L S + ++ Q A+ +++ +L ++ ++K++ L+ SL KD + L
Sbjct: 1111 STLNSQSTSLMN--QNAQLLIQQ-----SSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
Query: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
L E Q + E E L+ + +L++ + E ++ L +KG+
Sbjct: 1164 LLH---ERQAS----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL----- 1211
Query: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
E++ ++ + +E+ ++ +E K +A + K+ END L L +E ++ +
Sbjct: 1212 ---EDLEKMLK-VEQEKMLLE--NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK----QIQEKQG 2224
+ + + NSK E L+ + ++ + ++ L ++ E L++ +E +
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
Query: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
L ++ L+ ++LLE+ +++ E + ++ L N+L+ E + DQ K
Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEEKIMDQ--YKF 1382
Query: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERE 2344
+ S PP + R + L+ R KK + +E + L R ++ E
Sbjct: 1383 YDPS--PP-----RRRGNWITLKMRKLIKSKKDI-----NRERQKSLTLTPTRSDSSEGF 1430
Query: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
L++ + + ++ NS + +TL K M
Sbjct: 1431 LQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSM 1462
Score = 133 bits (334), Expect = 3e-30
Identities = 257/1224 (20%), Positives = 511/1224 (41%), Gaps = 154/1224 (12%)
Query: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
+ + L+ EL AK L+ EL++ T + LE+ + +L R +Q +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----ENMNLL 299
Query: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF---AEEMKAKN-- 530
RS + E + L+ +KA V LE+E+ K+ L+ + + EE+K N
Sbjct: 300 SDARSARMYRDELDALR----EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQV 355
Query: 531 -TSQETMLRDLQEKINQQENSL-TLEK----LKLAVADLEKQRDCSQDLLKKREHHIEQL 584
+TML D E + + L LEK LK + D+E +RD + KK E +E+
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR---KKIEELMEE- 411
Query: 585 NDKLSKTEKES--KALLSALELKK-KEYEELKE--EKTLFSCWKSENEKLLTQMESEKEN 639
N L +K+S ++L EL++ EL E +K+L L ++E E ++
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471
Query: 640 LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN-VLDSKSVEVETQKL 698
L + L T + + + + ++ +E + + LS ++ L N ++ K Q L
Sbjct: 472 LTKTVEELRTTVDSVEGNA----SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 699 AYMELQQKAEFSD------QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
+ +++KA+ + +++I+ + + L V L + Q+ +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI------SAEAR 581
Query: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
+D+ E + L + +K + L E +R + ++ H+ E+G E
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEHYK------EKGERAEELE 631
Query: 813 ECRLEADQSPKNSAILQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMK 869
E K + +LQ ++ +L+ + +E+ +Q NS+L+++ +L + + +
Sbjct: 632 N---ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 870 AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQE 929
E + + E SQ +E+ +NV E+L K +LQL N ++E+E+ ++
Sbjct: 689 LESLEK----ENSQLD---EENLELRRNV--ESLKCASMKMAQLQLENKELESEK---EQ 736
Query: 930 LKKSNHLLEDSLKE---LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
LKK LL+ S K+ L++ + L +E + + + + ++I++L E L+ N +L
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Query: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK-------LILLQRCEETGNAYEDL 1039
Q+ + ++ S +++ KS+ + + Q +++K L Q+ E E+
Sbjct: 797 -QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 1040 SQKYKAAQEKNSKLE----CLLNECTSLCENRKNELEQLKEA------FAKEHQEFLTKL 1089
+ K +++N L C L E K E +K A ++ +++
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 1090 AFAEERN---QNLMLELETV----QQALRSEMTDNQNNSKSEA---GGLKQEIMTLKEEQ 1139
++ N + L ELE + ++ L E + + E+ LK+ + +E+
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
Query: 1140 NKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
++ + + N+QL + +KT +N E ++K+R+ E P + E
Sbjct: 976 AALEARLEESTNYNQQLRQELKTVK--KNYE------ALKQRQDEERMVQSSPPISGEDN 1027
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ-EI 1258
+ +S +L+ K+ +L E E+ LQ E Q ++ L+ Q+ Q +I
Sbjct: 1028 KWERESQET----TRELLKVKD-RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Query: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
L+ + +E+ + + + Q +N+ L + MN+ +L L+ E ++
Sbjct: 1083 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
Query: 1319 TELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
E D +S + + + K ++++L++ + L+ + G +
Sbjct: 1143 KEREDLKS--------LYDSLIKDHEKLELLHERQASEYESLI-----SKHGTLKSAHKN 1189
Query: 1379 VSLAPLDESNSYEHL-----TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS 1433
+ + D + Y L L D E + QEK L H+ + ++ ++ +
Sbjct: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE--QEKMLLENKNHETVAAEYKKLCGEND 1247
Query: 1434 ELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDS 1493
L L E VL T+ +N + L LE+ + + S L
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSK---LEQTRLEAEFSKLKEQYQQLDITS-- 1302
Query: 1494 SFYRALLEQTGDMSLLSNLEGAV-SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE- 1551
+ LLS L+G + N+ +D++ LQ L + S VE+
Sbjct: 1303 ------TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1356
Query: 1552 --LESLCEVYRQSLEKLEEKMESQ 1573
++ L E+ RQ EKLEEK+ Q
Sbjct: 1357 QYIDKLNELRRQK-EKLEEKIMDQ 1379
Score = 95.1 bits (235), Expect = 9e-19
Identities = 189/895 (21%), Positives = 348/895 (38%), Gaps = 145/895 (16%)
Query: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
A K+ +L+ + +L+ EK+Q + L+ L+A+ +K E + L ENQRL +
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKK----TERLEVSYQGLDIENQRLQKT 771
Query: 76 CESLEKTKQKISHELQVKES-----QVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
E+ K Q++ ELQ E Q N +E +++S K++E+LE+E K + E + ++
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISS--KRLEQLEKENKSLEQETSQLEK 829
Query: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK------YNKEVEERKRLEAE 184
+ + +I T L + G+ ++ K Y + K LE E
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
K L K+A+ + D+ + + + EK L + +
Sbjct: 890 NKEL-VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE--------KIGLNKE 940
Query: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
+++ T R L K ++ LK + KI LE RL+
Sbjct: 941 RLLHDEQSTDDRYKLLESKLEST---------------LKKSLEIKEEKIAALEARLE-- 983
Query: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
N Q+L+ +L+ K + + L + +DE + Q+S +
Sbjct: 984 -----ESTNYNQQLRQELKTVK----KNYEALKQRQDE-----ERMVQSSPPISG----- 1024
Query: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
ED +R++ E+ R L+ K + L +R+ TL E K L +
Sbjct: 1025 ----EDNKWERESQETTRELLKVK---------DRLIEVERNNATLQAE----KQALKTQ 1067
Query: 425 LQQAKNMHNVLQAELDKL--TSVKQQLENNLEEFKQKLCRAEQAFQASQ----------- 471
L+Q + +N LQA++ L +V Q +N + + + E + SQ
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 472 -IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE--MKA 528
I+++ L E + KE LKS + ++ H + EL + +Q ++ +K+
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYESLISKHGTLKS 1185
Query: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD--LLKKREHHIEQLND 586
+ + E RDL+++ NQ L K K + DLEK Q+ LL+ + H
Sbjct: 1186 AHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEKMLKVEQEKMLLENKNH------- 1232
Query: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
E K L + Y +L +E + + LL + E+ L+++ +
Sbjct: 1233 --ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
Query: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
L+ + I S + N + L + NL E R+L + + + ++ T L+Q
Sbjct: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQN 1344
Query: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----- 761
E D H ++ Q ++ +L + + L +IMD+ + Y
Sbjct: 1345 MESKDLFH--------VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWIT 1396
Query: 762 -SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
+R L+KSK N + Q+SL + F + + S LE Q
Sbjct: 1397 LKMRKLIKSKKD---INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1453
Query: 821 ---SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
+ K+S + R+ L + + D K C ++ ++++ A Q
Sbjct: 1454 TLGTKKSSMVALKRLPFLR-----NRPKDKDKMKACYRRSMSMNDLVQSMVLAGQ 1503
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 198 bits (504), Expect = 6e-50
Identities = 444/2080 (21%), Positives = 821/2080 (39%), Gaps = 306/2080 (14%)
Query: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
LL Q +A+ EL K N + RL E L+LE ++E E ++ +
Sbjct: 96 LLAQSRAERDELAIKYNAVSERL---------------EQALRLEPGELETQEPRGLVRQ 140
Query: 339 C---RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
R +L A Y + Y +Q+ +L + L + + LEQ++ E+ E
Sbjct: 141 SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGE 200
Query: 396 FQEELSRQQRSFQTLDQECI-------------QMKARLTQELQQAKNMHNVLQAELDKL 442
+++ R Q L+ I Q+ A L ++L QA + + L ++ K+
Sbjct: 201 LEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKV 260
Query: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE----LRRSMEEMKKENNLLKSHSEQK 498
T+ + LE + R E++F A E+ L R + ++ + +K +E
Sbjct: 261 TNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTE-- 318
Query: 499 AREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL 558
R++ L EL + + ++ T LR + + LEK L
Sbjct: 319 -RDLLQLGGELARTSRAVQEA----------GLGLSTGLR-----LAESRAEAALEKQAL 362
Query: 559 AVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTL 618
A LE+Q +L++++ +Q+ L K + ++ L +K+ E + L++++
Sbjct: 363 LQAQLEEQ--LRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV- 419
Query: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER--VRTLEMDRENLS 676
N+ L ++E+ L+S + L+T+ + + R + + D E+
Sbjct: 420 -------NKDLTEKLEA----LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSES-G 467
Query: 677 VEIRNLHNVLDSKSVEVE--TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
V++ D+ + + + + ++ + + ++ C +S L +
Sbjct: 468 VQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLA-LIHS 526
Query: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
HK QL QD+ YE+ +DLL + L +E +R A+
Sbjct: 527 ALHKRQLQ----------VQDMRGRYEASQDLLGTLRKQLSDSESERR---------ALE 567
Query: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
+ + + + E + + +L +L SL+ +Q +L+++ E
Sbjct: 568 EQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627
Query: 855 ELVQIKGEIEENLMKAEQMHQSFVAETS------QRISKLQEDTSAHQNVVAETLSALEN 908
+L + E+ + E+ + V + + +R + E ++V+A+ L +
Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687
Query: 909 KEKELQLLNDKVETEQAEIQEL--KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
L D ++ E+AE+ E K +E L +L +E SL+ +S + +LN
Sbjct: 688 ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS-LSKLSALN- 745
Query: 967 REIEELTQENGTLKEINASLNQEKMNLI---QKSESFANYIDEREKSISELSDQYKQEKL 1023
E L Q+ L + A L +EK L +++E A E ++ + EL + + +
Sbjct: 746 ---ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
Query: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL--------- 1074
L A E L Q+ + + S+L+ L + + R+ ELEQ
Sbjct: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
Query: 1075 --------KEAFAKEHQEFLTKLAFAEERNQNLMLE---LETVQQALRSEMTDNQNN-SK 1122
KEA AKEH +L AE + L E L ++AL + + Q ++
Sbjct: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922
Query: 1123 SEAGGLKQEIMTLKEEQNKMQKEV--NDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
EA ++E + + + + KE +L +Q++ + + L ++ + + +E
Sbjct: 923 LEA---RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 1181 RESERNQCNFKPQMDLE----VKEISLDSYNAQLVQLEAML-RNKELKLQESEKEKECLQ 1235
++ + + DL+ KE + A+ QL++ L R +E L E EKE L
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 1236 HELQTIRGDLETSNL-QDMQSQEISGLKDCEIDA-EEKYISGPHELSTSQNDNAHLQCSL 1293
E+ ++ + + L + + Q+ LK+ E A EK + H L+T SL
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT---------ISL 1090
Query: 1294 QTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILND-- 1351
+ K + + E ++ L +EL D R++ A A+EV +L + + L
Sbjct: 1091 EMERQK-RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149
Query: 1352 DSGLLHGE-------LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
DS L E L+ED G E Q L ES +EVQ
Sbjct: 1150 DSCLREAEELRTQLRLLEDARDGLRRELLEAQRK-----LRESQE-------GREVQRQE 1197
Query: 1405 A-ELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN------LVLSTNLRNFQ 1457
A EL+ E + L + ++ S + + ++ SLK N L L R
Sbjct: 1198 AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV 1257
Query: 1458 GDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS 1517
G E++ GL+E + S L + R L E M +L + +
Sbjct: 1258 GKEAGELRTGLQE-----------VERSRLEAR------RELQELRRQMKMLDSENTRLG 1300
Query: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQ-GIM 1576
+ + E +R+ET + ++ SL EV RQ L+ + K++ Q G
Sbjct: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL-EVMRQELQVAQRKLQEQEGEF 1359
Query: 1577 KNKE---IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQ 1633
+ +E + LE+ +E+Q+LD R L + + E+ +L+A + + +
Sbjct: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELK-----LEAARAEAAELGLRLSAAEGRAQG 1414
Query: 1634 LSLEL-------EVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTP 1686
L EL A QL GL + R LG+ GR S P
Sbjct: 1415 LEAELARVEVQRRAAEAQLGGLRSALRRGLGL-------GR---------APSPAPRPVP 1458
Query: 1687 KHDVHQICDKDAQQDLNLDIEKITETGAVKPT-GECSGEQSPDTNYEPPGEDKTQGS-SE 1744
+ + + LN G+ P+ G + SPD + E +G+ E
Sbjct: 1459 GSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE-----AVRGALRE 1513
Query: 1745 CISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM 1804
+ EL +A D L Q N QL E ++ R R+++ + E
Sbjct: 1514 FLQELR----SAQRERDELRTQTSALNRQLAEMEAERDS------ATSRARQLQKAVAES 1563
Query: 1805 KE----LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV 1860
+E +D +L + +L + E+ E+ + + L L+ + + +++
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKI 1623
Query: 1861 ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
+ + LE DK +++ D + + +E EL R R + E +A
Sbjct: 1624 SKMKANETKLE--GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681
Query: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALDQ 1979
L+ ++ +Q + D+E K + E L+ ++ + G L D + T AL Q
Sbjct: 1682 LQDRVDSLQRQ----VADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQ 1737
Query: 1980 LSEKM---KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
S + ++K L+ + C H QV + E L +SE K + L E+
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDRQVLQ-------ERLDAARQALSEARKQSSSLGEQ 1790
Query: 2037 LQSLEKDSQALSLTKCELENQIAQLNK---------------------EKELLVKESESL 2075
+Q+L + L L + E E Q+ QL + E+ LL + SL
Sbjct: 1791 VQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSL 1850
Query: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE-KK 2134
Q L++ + EK V ++ A +EK ALR + + E +LR + +R+ E +
Sbjct: 1851 QRALAQLEAEKREVERS--ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908
Query: 2135 QLHIAE-KLKERERENDSLKDKVENLER-----ELQMSEENQELVILDAENSKAEVETLK 2188
L AE +L E +R+ L+ +V LE+ +L++ + Q+L + + EVE L+
Sbjct: 1909 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL------QQEVERLR 1962
Query: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228
+ + R+L+ E R L +Q+ +GQL +
Sbjct: 1963 SAQAQTERTLEARER---AHRQRVRGLEEQVSTLKGQLQQ 1999
Score = 166 bits (421), Expect = 3e-40
Identities = 239/1106 (21%), Positives = 443/1106 (40%), Gaps = 131/1106 (11%)
Query: 1789 VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
V+ ++D + + +++ + D + E+ L K LEK E + N DL+EKLE
Sbjct: 375 VLREKDLAQQQMQSDLDKADLSARVTELGLAVK-----RLEKQNLEKDQVNKDLTEKLEA 429
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENE----L 1904
+ +ET +G L+ ++ + D+ + V S ER D N L
Sbjct: 430 LESLRLQEQAALETEDG--EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL 487
Query: 1905 SRIR--------------------SEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
S R S S + + L Q + + E Q
Sbjct: 488 SGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQD 547
Query: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELES-------HQSE 1997
++ L ++LS SER L +L + KT Q E + + Q L S +S
Sbjct: 548 LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN 607
Query: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
H +QVA+ + +E + + L + EL + + L+E+ + +D + Q
Sbjct: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 2058 IAQLNKEKELLVKESESLQARLSES-------DYEKLNVSKALEAALVEKGEFALRLSST 2110
+ QL ++ +L KE ++ LS + EK V++AL A + E L ++
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL 727
Query: 2111 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ 2170
+ E L+ + KL E+ + +L + + + E E +L+ + E+E ++ E Q
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ 787
Query: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD 2230
E + E + E E + +E SL+V E L + L + + Q QL++L
Sbjct: 788 ERL----EELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
+ LS +EQ Q + E++ VE L+ +E G + A E+
Sbjct: 841 RQLSG-------REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
Query: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES-EHHADLLKGRVENLERELEIAR 2349
EE +LR E L L + ++QL L+ +E E L E L EL R
Sbjct: 894 TLSEEATRLRLEKEALEGSL-FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 2350 ----TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2405
QE A+L+ E + + Q+ R + + R+ E LQ+E+
Sbjct: 953 QQIIATQEKASLDKE----------LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 2406 ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ-EAC 2464
E +++ + E+ Q + Q++ + + L+ + +EL+E +AAL ++ E
Sbjct: 1003 E---------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGL 1053
Query: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL------------------QSSVNGL 2506
E + E EK L + L +++ + +S+VN L
Sbjct: 1054 LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113
Query: 2507 IQEVEDGKQKLEK----KDEEISRLKNQIQD----QEQLVSKLSQVEGEHQLWKEQNLEL 2558
E+ D + + E+ +E+ RL+ Q +D ++ + + ++ + +L ++ L
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
R +E ++K++ Q + L+ S E E + V K ++
Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233
Query: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
L+ + QK A L EE + AGEL+ L+E++ S+ E E EL++ +
Sbjct: 1234 ISLKLANEDKEQKLA-LLEEARTAVGKEAGELRTGLQEVERSR---LEARRELQELRRQM 1289
Query: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC 2738
+ + ++ E+AE Q RL E+ K+ E R++L E
Sbjct: 1290 KMLDSENT----RLGRELAELQGRLALGER--------AEKESRRETLGLRQRLLKGEAS 1337
Query: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQ----ILEELKKTKMDNLKYVNQLKKENERAQGK 2794
L + E+ + + +E + + LEE + T+ L + L+ + E A+ +
Sbjct: 1338 LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
Query: 2795 MKLLIKSCKQLEEEKEILQKELSQLQ 2820
L E + L+ EL++++
Sbjct: 1398 AAELGLRLSAAEGRAQGLEAELARVE 1423
Score = 157 bits (397), Expect = 2e-37
Identities = 283/1297 (21%), Positives = 537/1297 (41%), Gaps = 186/1297 (14%)
Query: 1848 YFSCDHQELL---QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
YFS +H LL ++V L S+++M ++ + +G +A+ + + +E L + L
Sbjct: 288 YFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ-LGGELARTSRAVQEAGLGLSTGL 346
Query: 1905 SRIRSE-KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
S +A++E +AL L+A LE +K+ EKD +Q + +LS +E L
Sbjct: 347 RLAESRAEAALEKQAL-LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTE---L 402
Query: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV 2023
+ + K+ DQ+++ + EK + LES L + A E ++ L QTL D+
Sbjct: 403 GLAVKRLEKQNLEKDQVNKDLTEKLEALES-----LRLQEQAALETEDGEGLQQTLR-DL 456
Query: 2024 SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-------------LVK 2070
++ + + +L E+ + A + + L Q +
Sbjct: 457 AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACS 516
Query: 2071 ESESL---QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
+S +L + L + + ++ EA+ G +LS ++ E L +++LR +
Sbjct: 517 DSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDK 576
Query: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
+ + +++ N+ L + NL LQ++++ E + + E +A E L
Sbjct: 577 TDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEEL 636
Query: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
+ Q + + + D +R E E +Q+++ +G+ S L K L + L +A
Sbjct: 637 RRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS---RAT 693
Query: 2248 IQIKEESKTAVEMLQNQLKELNEAVA-ALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
+Q +MLQ + E+ EA+ A G E+ E S+ EE L++S+ KL
Sbjct: 694 LQR--------DMLQAEKAEVAEALTKAEAGRVEL----ELSMTKLRAEEASLQDSLSKL 741
Query: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
A E+ + +L + + + + E L+GR E+E +AR QE LE + EV
Sbjct: 742 SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER--LEELRLEQEV 799
Query: 2367 --ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS----ELEIINSSFEN 2420
+ L+ + Q+ LE + T+R E+ L +L + ++S ELE +
Sbjct: 800 ARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859
Query: 2421 ILQEKE----QEKVQMKEKSSTAMEML--QTQLKELNERVAALHNDQEA----------- 2463
++ E +++ KE + A++++ + + + L+E L ++EA
Sbjct: 860 QVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
Query: 2464 ---CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN--------GLIQEV-- 2510
+A+ + L ++ + L L K L L + I Q + L+Q
Sbjct: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 2511 ------------EDGKQKLEKKDE--------EISRLKNQIQ-DQEQLVSKLSQVEGE-- 2547
E+ Q+L+++ E E ++L++Q+Q +QE+L+++L + E
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 2548 ---HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDK 2604
L +E++ L E +Q + + +S+ +L + L + S + E+E K D
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 2605 MSFVEK----VNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
S E+ VN +T++ +L+ + E A A+ L + L + L E +
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
Query: 2661 KDQLKELTLENSELKKS-LDCMHKDQVEKEGK--VREEIAEYQLRLHEAEKKHQAL---- 2713
+ QL+ L L++ L+ K + +EG+ R+E E + L E K+ +AL
Sbjct: 1160 RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSN 1219
Query: 2714 --LLDTNKQYEVE-------IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATT 2764
L K+ E E + +KL EE ++ E L++ +E+ S
Sbjct: 1220 EELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEAR 1279
Query: 2765 QILEELKKTKMDNLKYVN-QLKKENERAQGKMKLLIKSCKQLEEE-----KEILQKELSQ 2818
+ L+EL++ +M L N +L +E QG++ L ++ K+ E + +L+ E S
Sbjct: 1280 RELQELRR-QMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Query: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
QE Q + + E T + L +LEE + LD L + KLE A+
Sbjct: 1339 EVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL---KLEAAR 1395
Query: 2879 -----------------EMLETQVAHLCSQQSKQDS----------RGSPLLGPVVPGPS 2911
+ LE ++A + Q+ ++ RG L P P
Sbjct: 1396 AEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPR 1455
Query: 2912 PIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVMSGIHPAEDT 2971
P+P + + SG+ S E G P +P PA
Sbjct: 1456 PVPGSPAR---DAPAEGSGEGLNSPSTLECSPGSQPPSP---------------GPATSP 1497
Query: 2972 EGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMA 3008
+ +PE + +++ ++ + + LR T A
Sbjct: 1498 ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSA 1534
Score = 152 bits (383), Expect = 7e-36
Identities = 426/2124 (20%), Positives = 829/2124 (39%), Gaps = 230/2124 (10%)
Query: 547 QENSLTLEK----LKLAVADLEK---QRDCSQDL-LKKREHHIEQLNDKLSKTEKESKAL 598
QE LTLE L+ +V EK RD +QD + I ++ + + ++ ES L
Sbjct: 9 QEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTR-NLSQPESPVL 67
Query: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN----HLETCLKTQ 654
L A E+ L+EE L S E LL Q +E++ L K N LE L+ +
Sbjct: 68 LPATEMAS--LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLE 125
Query: 655 --QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQ 712
++++ E VR SVE+R +++ ++ +Y Q + Q
Sbjct: 126 PGELETQEPRGLVRQ--------SVELRR----------QLQEEQASYRRKLQAYQEGQQ 167
Query: 713 KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD- 771
+ + ++ + K Q + +LE +L S E+ E + LRD S+D
Sbjct: 168 RQAQLVQRLQGKILQYKKRCSELEQQLLERSGEL------------EQQRLRDTEHSQDL 215
Query: 772 -ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER--------SECRLEADQSP 822
++L+ E+ Q+ + Q AM + G SE + CR E +
Sbjct: 216 ESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEH-- 273
Query: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
A + +S ++ +S L ++V + + E M E+ +
Sbjct: 274 -REAAWRREEESFNAYFSNE---HSRLLLLWRQVVGFRRLVSEVKMFTER-------DLL 322
Query: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Q +L + A Q + L E + +K QA+++E + L E L
Sbjct: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLA 382
Query: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
+ Q+ S+ L+K ++S+ ++ ++ L ++N ++N L EK+ ++
Sbjct: 383 QQQMQSD---LDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLT-EKLEALESLR---- 434
Query: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
+ E+ +E + +Q L Q + LS + A N L L + T
Sbjct: 435 -LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493
Query: 1063 LCENR----KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE---TVQQALRSEMT 1115
R + + + A L + A + Q + ++ Q L +
Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553
Query: 1116 DNQNNSKSEAGGLKQEIMTLKEEQN-------KMQKEVNDLLQENEQLMKVMKTKHECQN 1168
++S+SE L++++ L+++ + Q+EV L NE L +
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613
Query: 1169 LESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK----ELKL 1224
+ + +ERE + Q +L + L+ VQ A +R + +L
Sbjct: 614 VAQQQAEELRQEREKLQ-----AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668
Query: 1225 QESEKEKECLQHELQTIRGDLETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQ 1283
++ E ++ L EL +R L + LQ DM E + + + AE +G EL S
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE----AGRVELELSM 724
Query: 1284 NDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL 1343
+ SLQ +++KL+ L + + + LV +L + +S + ++ AE+ +
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS-ALQGRQRQAEQEATVA 783
Query: 1344 NEVKILNDDSGLLHGELVEDIPGG-EFGEQPNEQHPVSLAPL--DESNSYEHLT-----L 1395
E + ++ L + + G EQ E L L + S E L L
Sbjct: 784 REEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
Query: 1396 SDKEVQMHFA--ELQEKFLSLQS---EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLS 1450
S +E ++ A E Q + +L+ E + L +H ++ ++ + +L E L
Sbjct: 844 SGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR 903
Query: 1451 TNLRNFQGDLVK-EMQLGLEEGLVPSLSSSCVPDSSSLSSL-GDSSFYRALLEQTGDMSL 1508
+G L + + QL E L + + +L G+ + R + T + +
Sbjct: 904 LEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS 963
Query: 1509 LSN------LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS 1562
L L A Q S+ E + EE+L R + A ELE+ +
Sbjct: 964 LDKELMAQKLVQAEREAQASLREQ--RAAHEEDLQRLQREKEAAW--RELEAERAQLQSQ 1019
Query: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMES 1622
L++ +E++ ++ + +E+ E L ER E L + SE +Q S +
Sbjct: 1020 LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE---SEKQQALSLKESEKTALSE 1076
Query: 1623 KLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETT 1682
KL + +SLE+E + Q RS + T + R + + + H E
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 1683 E-RTPKHDVHQICDKDAQQDLNLDIE-KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQ 1740
+ D+ + D ++ L + ++ E E Q + E + Q
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 1741 GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESL 1800
+ E L G A + E++ + VK+ +E + L ED+++K+ +L
Sbjct: 1197 EAGELRRSL---GEGAKEREALRRSNEELRSA---VKKAESERISLKLANEDKEQKL-AL 1249
Query: 1801 LNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV 1860
L E + K + +L T ++ E+E+ E ++E +L +++ ++ L + +
Sbjct: 1250 LEEARTAVGK---EAGELRTGLQ---EVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
Query: 1861 ETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
+G + E +S RE +G ++R L E L +R E + +
Sbjct: 1304 AELQGRLALGERAEKESRRETLG---------LRQRLLKGEASLEVMRQELQVAQRKLQE 1354
Query: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVC----LEEELSVVTSERNQLRGELDTMSKKTTA 1976
E + + L ++ +K + LE +L +E +L L +
Sbjct: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Query: 1977 LDQLSEKMKEKTQELESH----QSECLHCIQVAEAEVKEKTELLQTLSSDV-----SELL 2027
L+ +++ + + E+ +S + + A + + + D E L
Sbjct: 1415 LEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGL 1474
Query: 2028 KDKTHLQ-------------EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074
+ L+ S + D +A+ E ++ +E++ L ++ +
Sbjct: 1475 NSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSA 1534
Query: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134
L +L+E + E+ + + A +L E + RR ++ ++A+
Sbjct: 1535 LNRQLAEMEAERDSATSR-----------ARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583
Query: 2135 QLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Q E ++ ERE + D+V LER LQ +E KA L+ +
Sbjct: 1584 Q---EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
Query: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEES 2254
L E V L ++ +L ++Q + LS+ + + ++L + + + Q+ +S
Sbjct: 1641 KEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE---AQAQALQDRVDSLQRQV-ADS 1696
Query: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADE 2314
+ LQ ++ LN A+A + E+S ++ L ++ + A L +
Sbjct: 1697 EVKAGTLQLTVERLNGALAKV----------EESEGALRDKVRGLTEALAQSSASLNSTR 1746
Query: 2315 KKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV---ETLKA 2371
K L + + L EH +L+ R++ + L AR + + +GEV E +
Sbjct: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRV 1806
Query: 2372 KIEGMTQSLRGLELDVVTIRSEKENLT-NELQKEQERISELEIINSSFENILQEKEQEKV 2430
+ EG Q LR +V+ R E E N +QK Q+ L+ S + L + E EK
Sbjct: 1807 EAEGQLQQLR----EVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKR 1862
Query: 2431 QMKEKSSTAME----MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
++ E+S+ +E L+ L ++ H D A++ L + ELE A+
Sbjct: 1863 EV-ERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
Query: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
+ + + + +VL+ S + EV+ +Q+LE + +E+ RL++ E+ + +
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQ-QEVERLRSAQAQTERTLEARERAHR 1980
Query: 2547 EHQLWKEQNLELRNLTVELEQKIQ 2570
+ E+ ++ L +L+Q+++
Sbjct: 1981 QRVRGLEE--QVSTLKGQLQQELR 2002
Score = 143 bits (361), Expect = 2e-33
Identities = 416/2166 (19%), Positives = 825/2166 (38%), Gaps = 396/2166 (18%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDS----LEAALQKQKQKVENEKTEG-TNLKRENQRL 72
Q++ +E L + + E+ + + ++ LE AL+ + ++E ++ G E +R
Sbjct: 88 QELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQ 147
Query: 73 MEICESLEKTKQKISHELQVKESQ-VNFQEGQLNSGKKQIEKLEQELKRCKSELE----R 127
++ ++ + K + E Q +++Q V +G++ KK+ +LEQ+L ELE R
Sbjct: 148 LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLR 207
Query: 128 SQQAAQSADVSLNPCNTPQK----------IFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177
+ +Q + +L Q+ + L + + + ED+++ N
Sbjct: 208 DTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRC 267
Query: 178 RKRLEAEVKALQAKKA------SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231
RK LE A + ++ S + + R + + S E+ L
Sbjct: 268 RKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE 327
Query: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
RT + S + SR+ + K+ + + +L + Q+++
Sbjct: 328 LARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ 387
Query: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
+ +++ + L E+ V + ++ L+ ++ +L EK + L E +R Q
Sbjct: 388 SDLDKAD--LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL-----ESLRLQEQAA 440
Query: 352 QASTKYTALEQKLKKLTE----------DLSCQRQNAESARCSLE----QKIKEKEKEFQ 397
+ L+Q L+ L + LS + A+++ SL Q+ +
Sbjct: 441 LETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSS 500
Query: 398 EELSRQQR---SFQTLDQECIQM-KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
R R S D + + + L + Q ++M +A D L ++++QL ++
Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK 513
E + E+ Q + K + ++ E+ ++E L+S +E +R E N+
Sbjct: 561 SERR----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR-------EKSNLA 609
Query: 514 QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD- 572
L +Q AEE++ + L+ QE++ +Q + L E+Q D QD
Sbjct: 610 HSLQVAQQQAEELR----QEREKLQAAQEELRRQRDRLE-----------EEQEDAVQDG 654
Query: 573 -----LLKKREHHIEQLNDKLSKTEKESKALLSAL-------ELKKKEYEELKEEKTLFS 620
L++ +EQL K S KE + AL ++ + E E+ E T
Sbjct: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
Query: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680
+ E E +T++ +E+ +LQ ++ L ++ + N V LE ++ L R
Sbjct: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
Query: 681 NLHNVLDSKSVEVETQKLAYMELQQK------------AEFSDQKHQKEIENMCLKTSQL 728
++ E ++L + L+Q+ AE + + ++++ + + SQL
Sbjct: 775 QAEQ--EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQL 832
Query: 729 TGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Q+ L + LS + ++ ++ + E+L + K+A + L+A +
Sbjct: 833 QEQLAQLSRQ---LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889
Query: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
+ E ++ E + RLE ++LE SL ++ +
Sbjct: 890 R-------------EGRTLSEEATRLRLEK--------------EALEGSLFEVQRQLAQ 922
Query: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
L+ + E+L + +G+ L+ A++ +A Q+I QE S + ++A+ L E
Sbjct: 923 LEARREQL-EAEGQA---LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE- 977
Query: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE-KKEMSSIISLNKR 967
+E + L + E+ ++Q L++ E + +EL+ L + ++E +++ +
Sbjct: 978 REAQASLREQRAAHEE-DLQRLQREK---EAAWRELEAERAQLQSQLQREQEELLARLEA 1033
Query: 968 EIEELTQENGTLKEINAS----LNQEKMNLIQKSESFANYIDER----EKSISELSDQYK 1019
E EEL++E L++ EK + ES + E+ S++ +S + +
Sbjct: 1034 EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEME 1093
Query: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
++K R E+ + L+ + + + + + + + + +L + +++
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1153
Query: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
+E +E T+L E+ L EL Q+ LR E + + + EAG L++ + +E+
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLR-ESQEGREVQRQEAGELRRSLGEGAKER 1212
Query: 1140 NKMQKEVNDLL-----------------QENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
+++ +L ++ EQ + +++ E+ +R ++E E
Sbjct: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272
Query: 1183 SERNQCNFKPQMDLEVKEISLDSYNA----QLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
R + + Q +L + LDS N +L +L+ L E +ES +E L+ L
Sbjct: 1273 RSRLEARRELQ-ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRL 1331
Query: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
LE + +Q ++ E E+ + G E + + ++
Sbjct: 1332 LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE---------KQQLD 1382
Query: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAE-EVGKLLNEVKILNDDSGL-- 1355
LE E +AE EL L+ + ++A EV + E ++ S L
Sbjct: 1383 HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRR 1442
Query: 1356 --------------LHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLT------L 1395
+ G D P GE N + +P + S T L
Sbjct: 1443 GLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDL 1502
Query: 1396 SDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455
+ V+ E ++ S Q E L Q ++ +++E++ DS +
Sbjct: 1503 DPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR---------- 1552
Query: 1456 FQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGA 1515
+++Q + E +++G
Sbjct: 1553 -----ARQLQKAVAE----------------------------------SEEARRSVDGR 1573
Query: 1516 VSANQCSVDEVFCSSLQEENLTRKETP-SAPAKGVEELESLCEVYRQSLEKLEEKMESQG 1574
+S Q + +LQEE++ R E A V LE + L +EK+
Sbjct: 1574 LSGVQAEL------ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK-- 1625
Query: 1575 IMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1634
MK E + L +++ L K+ L +E +V LE+ Q L
Sbjct: 1626 -MKANETK-----LEGDKRRL----KEVLDASES-----RTVKLEL---------QRRSL 1661
Query: 1635 SLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQIC 1694
EL+ +RL L + +++L D D++Q Q+
Sbjct: 1662 EGELQRSRLGLSDREAQAQALQ--DRVDSLQ-------------------------RQVA 1694
Query: 1695 DKDAQQ-DLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSG 1753
D + + L L +E++ GA+ E G DK +G +E +++ S S
Sbjct: 1695 DSEVKAGTLQLTVERL--NGALAKVEESEGAL----------RDKVRGLTEALAQSSAS- 1741
Query: 1754 PNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL 1813
L + D NL L+ T+ E+ R V+++R L+E ++ S L
Sbjct: 1742 ---------LNSTRD-KNLHLQKALTACEHDR--QVLQERLDAARQALSEARKQSSSLGE 1789
Query: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH 1873
Q V L+ E +DL LQRVE L E+
Sbjct: 1790 Q-----------------VQTLRGEVADLE-------------LQRVEAEGQLQQLREVL 1819
Query: 1874 ADKSSREDIGDN-VAKVNDS---WKERFLDVENELSRIRSEKASIEHEALYLEAD----- 1924
+ E N V K+ D +ER ++ L+++ +EK +E AL LE D
Sbjct: 1820 RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
Query: 1925 --LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ--- 1979
L+ V+ EKL +D L+ L+ E + + ++ + + L+Q
Sbjct: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHS 1939
Query: 1980 -------LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032
++ E QE+E +S + EA + + ++ L VS L K
Sbjct: 1940 PAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL---KGQ 1996
Query: 2033 LQEKLQ 2038
LQ++L+
Sbjct: 1997 LQQELR 2002
Score = 142 bits (359), Expect = 4e-33
Identities = 371/1939 (19%), Positives = 766/1939 (39%), Gaps = 270/1939 (13%)
Query: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
S+E ++Q+ + Q +Q E ++ + Q Q + + +R S+L++
Sbjct: 141 SVELRRQLQEE-QASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
Query: 898 VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE 957
+ + ++L+ ++E EQ L + N +L + L + ++ LS + ++
Sbjct: 200 ELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRK 259
Query: 958 MSSIISLNKREIEELTQENGTLKE---INASLNQEKMNLI---QKSESFANYIDE----R 1007
+++ + ++E+E +E +E NA + E L+ ++ F + E
Sbjct: 260 VTNDWTRCRKELEH--REAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFT 317
Query: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067
E+ + +L + + + + + +AA EK + L+ L E R
Sbjct: 318 ERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR 377
Query: 1068 KNELEQLKEAFAKEHQEF---LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
+ +L Q + + + +T+L A +R + LE + V + L ++ ++ E
Sbjct: 378 EKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQE 437
Query: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHEC------------QN 1168
L+ E + +Q+ + DL Q ++E +++ ++ Q
Sbjct: 438 QAALETE------DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQR 491
Query: 1169 LESEPIRNSVKERESERN----QCNFKPQMDL-----EVKEISLDSYNAQLVQLEAMLRN 1219
S P R+S S R C+ + L +++ + + + +L
Sbjct: 492 TPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
Query: 1220 KELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHEL 1279
+L +SE E+ L+ +LQ +R + + MQ+ E + E + + +EL
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGA----MQAHE-------DAQREVQRLRSANEL 600
Query: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE---LNDSRSECITATRKMA 1336
+ + N L SLQ + EL + E LQA + EL + L + + + + ++
Sbjct: 601 LSREKSN--LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVR 658
Query: 1337 EEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLS 1396
E+ + +++ L +L ELVE E + Q + A +++ E LT +
Sbjct: 659 RELERSHRQLEQLEGKRSVLAKELVEV---REALSRATLQRDMLQA--EKAEVAEALTKA 713
Query: 1397 DK---EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNL 1453
+ E+++ +L+ + SLQ L + ++ +L V L+ E L
Sbjct: 714 EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQ 773
Query: 1454 RNFQGD--LVKEMQLGLEE----------GLVPSLSSSCVPDSSSLSSLGDSSFYRALL- 1500
R + + + +E Q LEE GL SL + + L R+ L
Sbjct: 774 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 833
Query: 1501 EQTGDMSLL-----SNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELE-- 1553
EQ +S LE A Q V+ + ++ ++E L ++ A E E
Sbjct: 834 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
Query: 1554 ------------------SLCEVYRQ--SLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
SL EV RQ LE E++E++G + L L+ RQ
Sbjct: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 1594 ELDCLRKQYLSENEQWQQKLTSVTLEMESKL----AAEKKQTEQLSLELEVARLQLQGLD 1649
++ +++ + E QKL E ++ L AA ++ ++L E E A +L+
Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 1650 LSSRSLLGIDTEDAIQGRN-ESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNL-DIE 1707
+S L + E+ + E ++S+E + ER + + + + QQ L+L + E
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD---EGLLLAESEKQQALSLKESE 1070
Query: 1708 KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE 1767
K + + T S + ++ + ++ E S NAL
Sbjct: 1071 KTALSEKLMGTRHSLATISLEM-------ERQKRDAQSRQEQDRSTVNALT--------S 1115
Query: 1768 DIHNLQLRVKETS----NENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQE-------- 1815
++ +L+ + +E + E RL D ++ +S L E +EL ++L L E
Sbjct: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
Query: 1816 --VQLMTKIEACIELEKI----VGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSD 1869
++ K+ E ++ GEL++ + +++ E ++EL V+ +E
Sbjct: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
Query: 1870 LEM-HADKS--------SREDIGDNVAKVNDSWKE---RFLDVENELSRIRSEKASIEHE 1917
L++ + DK +R +G ++ +E L+ EL +R + ++ E
Sbjct: 1236 LKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
Query: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
L +L +Q E+ + ++ + L + L + +R EL +K
Sbjct: 1296 NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK---- 1351
Query: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037
++E+ E + + L ++ A K++ + + L + + L +L
Sbjct: 1352 ------LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRL 1405
Query: 2038 QSLEKDSQALS--LTKCELENQIAQ---------------LNKEKELLVKESESLQAR-- 2078
+ E +Q L L + E++ + A+ L + + AR
Sbjct: 1406 SAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDA 1465
Query: 2079 LSESDYEKLNVSKALEA---------------ALVEKGEFALR--LSSTQEEVHQLRRGI 2121
+E E LN LE A + A+R L +E+ +R
Sbjct: 1466 PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRER 1525
Query: 2122 EKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ----------- 2170
++LR + A + +L E E E DS + L++ + SEE +
Sbjct: 1526 DELRTQTSA-------LNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578
Query: 2171 -ELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS 2227
EL + + ++E E T Q+ + RSL+ E +L R+ +E ++K + +
Sbjct: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESEL---RASQEKISKM----KANET 1631
Query: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
+L+ K +L+ E ++++ + ++ LQ L++ A Q+ + + ++
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQR 1691
Query: 2288 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE-----SEHHADLLKGRVENLE 2342
+ + L+ ++E+L L E+ + + +++ ++ A L R +NL
Sbjct: 1692 QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLH 1751
Query: 2343 RELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQ 2402
L+ A T EH + + L+ +++ Q+L R + +L ++Q
Sbjct: 1752 --LQKALTACEH----------DRQVLQERLDAARQALS-------EARKQSSSLGEQVQ 1792
Query: 2403 KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM---EMLQTQLKELNERVAALHN 2459
+ +++LE+ E LQ+ + Q +E + A+ + LQ + + L ER+ +L
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
Query: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
+A+++ + LE ++ L + LD+ + + L E + L
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTG 1912
Query: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL 2579
+ E++ + QIQ E V L Q QL ++ + +EL+Q+++ L+S A
Sbjct: 1913 AELELAEAQRQIQQLEAQVVVLEQSHSPAQL----EVDAQQQQLELQQEVERLRSAQAQT 1968
Query: 2580 QDTLEVLQSSYKNLENELE 2598
+ TLE + +++ LE
Sbjct: 1969 ERTLEARERAHRQRVRGLE 1987
Score = 142 bits (357), Expect = 7e-33
Identities = 269/1339 (20%), Positives = 538/1339 (40%), Gaps = 227/1339 (16%)
Query: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS---KLHLQEVQLMTKI 1822
Q ++ L+ + S E L H ++ ++ E L E ++L + +L Q +L +
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 1823 EACIE---------------LEKIVGE---LKKENSDLSEKLEYFSCDHQEL-LQRVETS 1863
E ++ LE++ G+ L KE ++ E L + L ++ E +
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
Query: 1864 EGLN-----------SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
E L S ++ A+++S +D ++ +N+S + LD+ ++++ EK+
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972
+++ E + V + E+ LE+ ++ LE L V + L +L T+
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Query: 1973 KTTALD----QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL- 2027
+ + L QLS ++ + QELE + E ++ E +EK L + + +L+
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 2028 --KDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ--------- 2076
++ L E+ L + +AL + E++ Q+AQL +E L E ++L
Sbjct: 888 AEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGE 947
Query: 2077 -ARLSE---SDYEKLNVSKALEAALVEKGEFALRLS------STQEEVHQLRRGIEKLRV 2126
A L + + EK ++ K L A + + E + S + +E++ +L+R E
Sbjct: 948 LAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWR 1007
Query: 2127 RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVET 2186
+EA E+ QL ++ +E+E L+ + E L E+ ++ ++ +L AE+ K + +
Sbjct: 1008 ELEA-ERAQLQ-SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
Query: 2187 LKTQIEEMARSLKVFEL--DLVTLRSEKENLTKQIQEKQGQ-LSELDKLLSSFKSLLEEK 2243
LK + E+ A S K+ L T+ E E + Q +Q Q S ++ L S + L ++
Sbjct: 1066 LK-ESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQR 1124
Query: 2244 EQAE------------------------IQIKEESKTAVEMLQNQL----KELNEAVAAL 2275
E+A ++ EE +T + +L++ +EL EA L
Sbjct: 1125 EEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL 1184
Query: 2276 CGDQEIMKATEQ-------SLDPPIEEEHQLRNSIEKLRARLEA-------------DEK 2315
QE + Q SL +E LR S E+LR+ ++ D++
Sbjct: 1185 RESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE 1244
Query: 2316 KQLCVLQQ---------------LKESEHHADLLKGRVENLERELEI-----ARTNQEHA 2355
++L +L++ L+E E + ++ L R++++ R +E A
Sbjct: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
Query: 2356 ALEAENSKGEVETLKAKIE--GMTQSLRGLELDVVTIRSEKENLTNELQKEQE--RISEL 2411
L+ + GE +++ E G+ Q L E + +R E + +LQ+++ R E
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
Query: 2412 EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
++ S E EK+Q + +E + + EL R++A + +A+ +
Sbjct: 1365 RLLGSLEEARGTEKQQ--LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV 1422
Query: 2472 SSQVECLELEKAQL------------------------------LQGLDEAKNNYIVLQS 2501
Q E + L +G E N+ L+
Sbjct: 1423 EVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLEC 1482
Query: 2502 S-----------------------VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538
S V G ++E Q+L E L+ Q L
Sbjct: 1483 SPGSQPPSPGPATSPASPDLDPEAVRGALREF---LQELRSAQRERDELRTQTS---ALN 1536
Query: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN------ 2592
+L+++E E + +L+ E E+ + + + + +Q L + + S +
Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR 1596
Query: 2593 --------LENELELTKMDKMSFVEKVNKMTAKETELQ---REMHEMAQKTAELQEELSG 2641
LE L+ T+ + + EK++KM A ET+L+ R + E+ + +L
Sbjct: 1597 ATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLEL 1656
Query: 2642 EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701
++ L GELQ + + Q + L L++ + D K G ++ +
Sbjct: 1657 QRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV----ADSEVKAGTLQLTVERLNG 1712
Query: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761
L + E+ AL E Q+ +++++ L QK + + ++ L L
Sbjct: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK-ALTACEHDRQVLQERLD 1771
Query: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQK----ELS 2817
A Q L E +K + V L+ E + + +++ QL++ +E+L++ E +
Sbjct: 1772 AARQALSEARKQSSSLGEQVQTLRGEVADLELQR---VEAEGQLQQLREVLRQRQEGEAA 1828
Query: 2818 QLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKA 2877
L Q+ Q ++ ++ L + +L+ E + A +L + +K+E+
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
Query: 2878 KEMLETQVAHLCSQQSKQD 2896
K L +++ + D
Sbjct: 1889 KLRSHEDTVRLSAEKGRLD 1907
Score = 114 bits (285), Expect = 2e-24
Identities = 209/978 (21%), Positives = 404/978 (41%), Gaps = 148/978 (15%)
Query: 12 LPTRALQKIQELEGQ-------LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
L R LQ +Q++ G+ L L+K+ + + +LE LQ+ + K + +
Sbjct: 528 LHKRQLQ-VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
Query: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
+RE QRL E L + K ++H LQV + Q +L +++++ ++EL+R +
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAE----ELRQEREKLQAAQEELRRQRDR 642
Query: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE 184
LE Q+ A G++ E+ ++++E+ + +
Sbjct: 643 LEEEQEDA-------------------------VQDGARVRRELERSHRQLEQLEG-KRS 676
Query: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
V A + + + L +AT+ + +A + + E
Sbjct: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE---------------------- 714
Query: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
+G E+ S + L+ + S S+ L Q K L ++ E + LQG
Sbjct: 715 --AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR 772
Query: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
+++ + + +E Q +LE+ ++E ++V + + +R Q + ALEQ+L
Sbjct: 773 QRQAEQEATVAREEQERLEELRLE----QEVARQGLEGSLRVAEQAQE------ALEQQL 822
Query: 365 KKLTEDLS-CQRQNAESAR--CSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQECIQMK 418
L + S Q Q A+ +R EQ++++ +E Q E L R R + L +E
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE----H 878
Query: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
A L +L A+ L E +L K+ LE +L E ++ Q+ + E R
Sbjct: 879 AGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR------------QLAQLEAR 926
Query: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
R E + + LL + L EL ++Q Q A + KA + +E M +
Sbjct: 927 REQLEAEGQALLLAKET---------LTGELAGLRQ-----QIIATQEKA-SLDKELMAQ 971
Query: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
L + + + SL E+ DL++ + + ++ E QL +L ++E + L
Sbjct: 972 KLVQAEREAQASLR-EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL---QREQEEL 1027
Query: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
L+ LE +K EEL EE + + E ++ L ESEK+ S +T L ++++
Sbjct: 1028 LARLEAEK---EELSEE---IAALQQERDEGLLLAESEKQQALSLKESEKTAL-SEKLMG 1080
Query: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEI 718
++ +LEM+R+ + R D +V T +L +L+ + E + H +E+
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQ---DRSTVNALTSEL--RDLRAQREEAAAAHAQEV 1135
Query: 719 ENMCLKTSQLTGQ-------VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
+ + L Q E+L +L+LL + +D ++L LR+ + ++
Sbjct: 1136 RRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA---RDGLRRELLEAQRKLRESQEGRE 1192
Query: 772 ASLVTNEDHQRSL-LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQ- 829
+ +RSL ++ A+ S + SER +L + + A+L+
Sbjct: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEE 1252
Query: 830 ------NRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEENLMKAEQMH--QSFVAE 880
L L+ ++ + +++ +EL Q+K EN ++ Q +A
Sbjct: 1253 ARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Query: 881 TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI--QELKKSNHLLE 938
+ + + +T + + + ++LE +ELQ+ K++ ++ E +E + L E
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
Query: 939 DSLKELQLLSETLSLEKK 956
E Q L LE K
Sbjct: 1373 ARGTEKQQLDHARGLELK 1390
Score = 105 bits (263), Expect = 5e-22
Identities = 258/1319 (19%), Positives = 518/1319 (39%), Gaps = 149/1319 (11%)
Query: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ----RVE 1861
E+ S L LQE + + E +E ++ + + E +L+ K S ++ L+ +E
Sbjct: 72 EMASLLSLQEENQLLQQELS-RVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELE 130
Query: 1862 TSEG---LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR--IRSEKASIEH 1916
T E + +E+ + + ++R + L ++ +K E
Sbjct: 131 TQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSEL 190
Query: 1917 EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL---SVVTSERNQLRGELDTMSKK 1973
E LE E+ Q ++L + +++ + ++ LEEE + + LR +LD
Sbjct: 191 EQQLLERSGELEQ-QRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSA 249
Query: 1974 TTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT-LSSDVSELLK---- 2028
AL SE +++ T + + E H EA + + E S++ S LL
Sbjct: 250 NQAL---SEDIRKVTNDWTRCRKELEH----REAAWRREEESFNAYFSNEHSRLLLLWRQ 302
Query: 2029 ---DKTHLQEKLQSLEKDSQALS--LTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083
+ + E E+D L L + Q A L L + ES + +A L +
Sbjct: 303 VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA-EAALEKQA 361
Query: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLK 2143
+ + + L ++ + + A + + + L + +L + ++ EK+ L
Sbjct: 362 LLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNL------- 414
Query: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE----------E 2193
E+++ N L +K+E LE S QE L+ E+ + +TL+ + +
Sbjct: 415 EKDQVNKDLTEKLEALE-----SLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQ 469
Query: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQ------------LSELDKLLSSFKSLLE 2241
++ S + + +LR T + L+ S L
Sbjct: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
Query: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
+++ ++ + + ++L K+L+++ + +E ++ D ++ +
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
Query: 2302 SIEKLRA--RLEADEKKQLC-----VLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2354
+++LR+ L + EK L QQ +E + L+ E L R+ + QE
Sbjct: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
Query: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS-------EKENLTNELQKEQER 2407
A + + E+E ++E + L ++V +R +++ L E + E
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 2408 ISELEIINSSFENILQEKEQEKVQMKE---KSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
+++ E E + + E+ +++ K S E L +LN VA L ++ A
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 769
Query: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI 2524
+ +++ + E+ + L+E + V + + G ++ E ++ LE++ +
Sbjct: 770 QGRQRQAEQEATVAREEQ----ERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 2525 SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE 2584
++Q+ QEQL Q+ G Q EL E +++++ L+ E
Sbjct: 826 RHERSQL--QEQLAQLSRQLSGREQ-------ELEQARREAQRQVEALERAARE----KE 872
Query: 2585 VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ---EELSG 2641
L + L +L + + + E+ ++ ++ L+ + E+ ++ A+L+ E+L
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
Query: 2642 EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK--VREEIAEY 2699
E L + L E+ + Q+ T E + L K L Q E+E + +RE+ A +
Sbjct: 933 EGQALLLAKETLTGELAGLRQQI-IATQEKASLDKELMAQKLVQAEREAQASLREQRAAH 991
Query: 2700 QLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS 2759
+ L +++ +A ++ E E + +L ++E L ++ L++ KEEL+
Sbjct: 992 EEDLQRLQREKEAAW----RELEAERAQLQSQLQREQEELLAR------LEAEKEELSEE 1041
Query: 2760 LKATTQ------ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
+ A Q +L E +K + +LK ++ +E+ G L ++E +K
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLK-ESEKTALSEKLMGTRHSLATISLEMERQKR--- 1097
Query: 2814 KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEK 2873
Q+ QE+ + + V+ LT+E+++L+ EE A + + L
Sbjct: 1098 ----DAQSRQEQDR------STVNALTSELRDLRAQREE---AAAAHAQEVRRLQEQARD 1144
Query: 2874 LEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQ 2933
L K ++ + L +Q + L ++ + E R Q + +G+ +
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQRQEAGELR 1202
Query: 2934 RSSGIWENGRGPTPATPESFSKKSKKAVMSGIH---PAEDTEGTEFEPEGLPEVVKKGFA 2990
RS G R + E KKA I ED E E V K
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262
Query: 2991 DIPTGKTSPYILRRTTMATRTSPRLAAQKLALSP--LSLGKENLAESSKPTAGGSRSQK 3047
++ TG + R A R L Q L LG+E LAE A G R++K
Sbjct: 1263 ELRTGLQE--VERSRLEARRELQELRRQMKMLDSENTRLGRE-LAELQGRLALGERAEK 1318
Score = 103 bits (258), Expect = 2e-21
Identities = 243/1238 (19%), Positives = 494/1238 (39%), Gaps = 135/1238 (10%)
Query: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63
A E ++ LPT ++ Q L+ QL +L ++ R+ +L+ Q+Q + +E E
Sbjct: 814 AQEALEQQLPTLRHERSQ-LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872
Query: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
L +E+ L + E+ + +S E + EG L ++Q+ +LE ++ ++
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
Query: 124 E-----LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE---DLKEKYNKEV 175
E L + + A + T +K +Q ++ E L+E+
Sbjct: 933 EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE 992
Query: 176 EERKRLEAEVKA----LQAKKAS-----QTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226
E+ +RL+ E +A L+A++A Q + + + + + S + + QQE+
Sbjct: 993 EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEG 1052
Query: 227 HLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTL-------QIGKRDANSSFFDNSSSPHL 279
L + S++ + + +++ +R +L + KRDA S + S+
Sbjct: 1053 LLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST--- 1109
Query: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLE---KAKVELIEKEKVL 336
+ A ELR+ + E H +E++ + ++L Q + + EL + ++L
Sbjct: 1110 ---VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL 1166
Query: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE--K 394
RD L R + ++KL++ E QRQ A R SL + KE+E +
Sbjct: 1167 EDARDGLRRELLE----------AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALR 1216
Query: 395 EFQEELSRQQRSFQTLDQECIQMKAR---LTQELQQAKNMHNVLQAELDKLTSVKQQLEN 451
EEL + + + + E I +K Q+L + + E +L + Q++E
Sbjct: 1217 RSNEEL---RSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 452 NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL------ 505
+ E +++L + + + L R + E++ L + ++ RE L
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
Query: 506 -EAELKNIKQCLNQSQNFAEEMKAK-NTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
EA L+ ++Q L +Q +E + + T + +L L+E ++ L+ + L
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ--LDHARGLELKL 1391
Query: 564 EKQRDCSQDL---LKKREHHIEQLNDKLSKTE---KESKALLSALELKKKEYEELKEEKT 617
E R + +L L E + L +L++ E + ++A L L + L +
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451
Query: 618 LFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS------------------- 658
+ E E L S + LE C Q S
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEGLNSP-STLE-CSPGSQPPSPGPATSPASPDLDPEAVRG 1509
Query: 659 --HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
E+ + +R+ + +R+ L + L+ L E ++ +LQ+ S++ +
Sbjct: 1510 ALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS 1569
Query: 717 EIENMCLKTSQLTGQVEDL---EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
+ ++L Q E + E + + +++ +R Q +E + ++ + A+
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
E +R L + A + ++ S+ E RL + LQ+RVD
Sbjct: 1630 ETKLEGDKRRLK--EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN----------LMKAEQMHQSFVAETSQ 883
SL+ + + LQ E L ++EE+ L +A + + T
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747
Query: 884 RISKLQEDTSA---HQNVVAETL----SALENKEKELQLLNDKVETEQAEIQELKKSNHL 936
+ LQ+ +A + V+ E L AL K+ L ++V+T + E+ +L+
Sbjct: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
Query: 937 LEDSLKEL-QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
E L++L ++L + E ++++ L + E L + G+L+ A L EK +
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKL-QDERRLLQERLGSLQRALAQLEAEK----R 1862
Query: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
+ E A +++ ++ D+ ++EKL ++ED + + EK
Sbjct: 1863 EVERSALRLEKDRVALRRTLDKVEREKL----------RSHED---TVRLSAEKGRLDRT 1909
Query: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
L L E ++ +++QL+ Q A E Q LEL+ + LRS
Sbjct: 1910 LTGAELELAEAQR-QIQQLEAQVVVLEQSH--SPAQLEVDAQQQQLELQQEVERLRSAQA 1966
Query: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
+ ++ +Q + L+E+ + ++ ++ L+ +
Sbjct: 1967 QTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 196 bits (498), Expect = 3e-49
Identities = 257/1175 (21%), Positives = 506/1175 (43%), Gaps = 155/1175 (13%)
Query: 1812 HLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE 1871
H Q ++ TK++ +++ + EL+ ++ +L + E + EL + + L +
Sbjct: 831 HWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKN 890
Query: 1872 MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE 1931
+ A++ E E F + E +R+ ++K +E LE+ +E +
Sbjct: 891 ILAEQLQAET-------------ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937
Query: 1932 KLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL 1991
L+ + + Q I LEE+L R +L+ E T K +KM+E+ L
Sbjct: 938 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI-------KKMEEEILLL 990
Query: 1992 ESHQSECLH------------CIQVAEAEVKEKT-----ELLQTLSSDVSELLKDKTHLQ 2034
E S+ + Q+AE E K K + + SD+ E LK + +
Sbjct: 991 EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE---E 1047
Query: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKE----KELLVKESESLQARLSESDYEKLN-- 2088
+ Q LEK + L +L++QIA+L + K L K+ E LQ L+ D E L+
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 2089 ----VSKALEAALVE-----KGEFALRLSSTQEEVHQLRRGIEKLRVRI----------- 2128
V + L+A + E + E A R + +++ L +E L+ +
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASR-NKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 2129 EADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVET-- 2186
E K++ +AE K E E + + +++++ + + E + A+ KA +E
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 2187 --LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL------------ 2232
L+T +E+A +KV + +++ L Q+QE ++SE D+L
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 2233 --LSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ--- 2287
L + +LLEE E+ I+ +++ + LQ+ + L E ++ E+
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 2288 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347
SL EEE + R ++ EK+ L + QL +++ D G +E+LE +
Sbjct: 1347 SLQEQQEEEEEARKNL----------EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
+ E + E + L+ + Q L L +D+ R NL + +K +
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467
++E + I++ + +E+++ + + +EK + A+ + + +EA +AK
Sbjct: 1457 LAEEKSISARY---AEERDRAEAEAREKETKALSLARAL--------------EEALEAK 1499
Query: 2468 EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRL 2527
E+ Q + L + L+ D+ N L+ S L Q+VE+ + +LE+ ++E+
Sbjct: 1500 EE-FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 2528 KN-QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV----ELEQKIQVLQSKNASLQDT 2582
++ +++ + + + +Q E + Q EQN E + L + ELE +++ + + A +
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL---QEEL 2639
+ ++ K+LE ++E + ++++ K+ A+ + QRE+ E E+ +E
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 2640 SGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ---VEKEGKVREEI 2696
+ L E+ L EE+ SS+ + E EL + + ++++ ++ I
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 2756
A+ + L E E+ + LL D ++ +++ T +L ++ S + D + E
Sbjct: 1739 AQLEEELEE-EQSNMELLNDRFRKTTLQVDTLNAELAAER----SAAQKSDNARQQLERQ 1793
Query: 2757 NNSLKATTQILEELKKTKMDNL---------KYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
N LKA Q LE K+K + QL++E + KL+ ++ K+L+E
Sbjct: 1794 NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKE 1853
Query: 2808 EKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL 2867
+Q E + A Q K+ ++++ +K+LK LEE +EA L
Sbjct: 1854 --IFMQVEDERRHADQYKE--------QMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 2868 LISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPL 2902
+ +A E L +V+ L + RG P+
Sbjct: 1904 QRELDDATEANEGLSREVSTL----KNRLRRGGPI 1934
Score = 183 bits (464), Expect = 3e-45
Identities = 262/1209 (21%), Positives = 529/1209 (43%), Gaps = 170/1209 (14%)
Query: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQ---ELEQLLSSERQELDCLRKQYLSENE 1607
+++ L +V RQ E+L+ K E +K K+ + ELE++ +Q L+ K L+E
Sbjct: 840 KVKPLLQVTRQE-EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE--EKNILAEQL 896
Query: 1608 QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGR 1667
Q + +L + EM ++LAA+K++ E++ +LE +R++ + + R
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLE-SRVEEE------------------EER 937
Query: 1668 NESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE----CSG 1723
N+ K+ + D+ + D++ L +EK+T +K E
Sbjct: 938 NQILQNEKKKMQAHIQ-----DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992
Query: 1724 EQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE-DIHNLQLRVKETSNE 1782
+ S + ED+ +EC S+L+ A QE I +L+ R+K+
Sbjct: 993 QNSKFIKEKKLMEDRI---AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049
Query: 1783 NLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTK--------------------- 1821
L D + L +++ EL +++ ++QL K
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 1822 IEACIELEKIVGEL--------------KKENSDLSEKLEYFSCDHQELLQRVETSEGLN 1867
++ EL+ + EL +K+ DLSE+LE + ++ L + L
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 1868 SDLEMHA---DKSSREDIGDNVAKVNDSWKERFLDVE---NELSRIRSEKASIEHEALYL 1921
+ E K+ E+ ++ A++ D + +E +L + + KA++E L
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Query: 1922 EADLEVVQTEKLCLEK---DNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTAL 1977
E D + + E L++ ++E+K+K + +EL SE ++LR EL + SK L
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 1978 DQLS---EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034
D +S E+ ++K + + +Q + ++E+T LSS + +L ++K LQ
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
E+ + E+ + L L++Q+A K+ + + ESL+ E+ + L ++AL
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE----EAKKKLLKDAEALS 1405
Query: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2154
L EK AL ++ ++L++ ++ L V D Q +A L++++++ D L
Sbjct: 1406 QRLEEK---ALAYDKLEKTKNRLQQELDDLTV----DLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 2155 KVENLERELQMSEENQELVILDAEN-----SKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
+ +++ + E + E ++A E L+ + EE R K D+ L
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK-EEFERQNKQLRADMEDLM 1517
Query: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
S K+++ K + E + L++ + ++ LEE E E+Q E++K +E+ +K
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED-ELQATEDAKLRLEVNMQAMKAQF 1576
Query: 2270 EAVAALCGDQ-----EIMKATEQSLDPPIEEEHQLRN-----------SIEKLRARLEAD 2313
E +Q ++ + L+ +E+E + R ++ L A++EA
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
K + V++QL++ L+ ++++ +RELE AR +++ +++ S+ ++++L+A+I
Sbjct: 1637 NKARDEVIKQLRK-------LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
+ + L E E++ L +E+ S L E + + E+E
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE----L 1745
Query: 2434 EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
E+ + ME+L + ++ +V L+ + A ++ Q + + LE + +L L E
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE-- 1803
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI-QDQEQLVSKLSQVEGEHQLWK 2552
L+ +V K IS L+ +I Q +EQL + + ++L +
Sbjct: 1804 -----LEGAVK-------------SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN 2612
+L+ + +++E + + ++ +E + K L+ +LE + E+
Sbjct: 1846 RTEKKLKEIFMQVEDE----RRHADQYKEQMEKANARMKQLKRQLEEAE-------EEAT 1894
Query: 2613 KMTAKETELQREMHEMAQKTAELQEELSGEKNRL--AGELQLLLEEIKSSKDQLKELTLE 2670
+ A +LQRE+ + + L E+S KNRL G + SS+ ++L LE
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI-----SFSSSRSGRRQLHLE 1949
Query: 2671 NSELKKSLD 2679
+ L+ S D
Sbjct: 1950 GASLELSDD 1958
Score = 166 bits (420), Expect = 3e-40
Identities = 240/1101 (21%), Positives = 466/1101 (42%), Gaps = 118/1101 (10%)
Query: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD 341
+L A+ QEL +++LE R++ E+ + N+ +++Q ++ + +L E+E K +
Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971
Query: 342 ELVRTTAQYDQASTKYTALEQ------KLKKLTED--LSCQRQNAESARCSLEQKIKEKE 393
E V A+ + + LE K KKL ED C Q AE +EK
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE---------EEKA 1022
Query: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
K + ++Q+ L +E ++ + + QEL++AK L E L +L+ +
Sbjct: 1023 KNLAKIRNKQEVMISDL-EERLKKEEKTRQELEKAKRK---LDGETTDLQDQIAELQAQI 1078
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK 513
+E K +L + E+ Q + L R +E +NN LK E +A ++ L+ + ++ K
Sbjct: 1079 DELKLQLAKKEEELQGA------LARGDDETLHKNNALKVVRELQA-QIAELQEDFESEK 1131
Query: 514 QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL 573
S+N AE+ K RDL E+ LE LK + D Q+L
Sbjct: 1132 ----ASRNKAEKQK----------RDLSEE---------LEALKTELEDTLDTTAAQQEL 1168
Query: 574 LKKREHHIEQLNDKLSKTEKESKALLSALELK-KKEYEELKEEKTLFSCWKSENEKLLTQ 632
KRE + +L L + K +A + + + EEL E+ +K+ EK
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228
Query: 633 MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD-------RENLSVEIRNLHNV 685
+E++ + L ++ L+ + K + + +V+ L R L+ + L N
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE 1288
Query: 686 LDSKSV---EVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
LD+ S E E + + + + E Q Q+ ++ + L+ ++ LE + L
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 743 SNEIMDKDRCYQDLH----AEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFA 798
+ +++ ++L A L D K D L T E ++ +
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE-------------SLEEAKK 1395
Query: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
++ + ++ E L D+ K LQ +D L L+ Q+Q+ S+L+K+ ++ Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 859 IKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLND 918
+ EE + A + AE R + + + A + E L A E E++ + L
Sbjct: 1456 LLA--EEKSISARYAEERDRAEAEAREKETKALSLA--RALEEALEAKEEFERQNKQLRA 1511
Query: 919 KVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978
+E + ++ K+ H LE S + L+ E + + +E+ L E +L E
Sbjct: 1512 DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED--ELQATEDAKLRLE-VN 1568
Query: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSI-SELSDQYKQEKLILLQRCEETGNAYE 1037
++ + A ++ +++E + ++ + + +EL D+ KQ L + + ++ +
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK-KKMEIDLK 1627
Query: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK----EAFAKEHQEFLTKLAFAE 1093
DL + +AA + ++ L + + ++ + ELE+ + E FA + +E KL E
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA-QSKESEKKLKSLE 1686
Query: 1094 ERNQNLMLELETVQQAL------RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
L EL + ++A R E+ D NS S L E L+ ++++E
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE-- 1744
Query: 1148 DLLQENEQLMKVMKTKHECQNLESEPIRNSV-KERESERNQCNFKPQMDLEVKEISLDSY 1206
L+E + M+++ + L+ + + + ER + + N + Q++ + KE+
Sbjct: 1745 --LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL----- 1797
Query: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
A+L +LE +++K K S E + Q E Q + E + + + LK+ +
Sbjct: 1798 KAKLQELEGAVKSK-FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 1267 DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRS 1326
E++ + NA ++ +L E E+ A + +L EL+D+
Sbjct: 1857 QVEDERRHADQYKEQMEKANAR----MKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Query: 1327 ECITATRKMAEEVGKLLNEVK 1347
A ++ EV L N ++
Sbjct: 1913 ----ANEGLSREVSTLKNRLR 1929
Score = 155 bits (391), Expect = 8e-37
Identities = 229/1183 (19%), Positives = 499/1183 (42%), Gaps = 141/1183 (11%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM 73
TR +++Q + +L K+K+++ + + +L+ +E +K +Q +E + L+ E +
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEME---RKHQQLLEEKNILAEQLQAETELFA 904
Query: 74 EICE------SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELER 127
E E + ++ ++I H+L+ + + + L + KK+++ Q+L+ E E
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 128 SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA 187
++Q Q EK E + K++E E+
Sbjct: 965 ARQKLQ----------------------------------LEKVTAEA-KIKKMEEEILL 989
Query: 188 LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247
L+ + + + M R IA SS + ++EK + +++ + D
Sbjct: 990 LEDQNSKFIKEKKLMEDR-IAE---CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 248 GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
E+ +R L+ KR + D L+ Q EL+ +I+EL+L+L E+E
Sbjct: 1046 EEK----TRQELEKAKRKLDGETTD----------LQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 308 MKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367
++G + + + L A + E + + + +++ A ++A + L ++L+ L
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151
Query: 368 ---TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
ED + R EQ++ E +K +EE + Q + Q L+++
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ 1211
Query: 425 LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEM 484
L+QAK +A L+K KQ LE + +E ++ +Q S+ K +L ++E+
Sbjct: 1212 LEQAKR----FKANLEK---NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 485 K---KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ 541
E + L+ +KA + L+ EL N+ L +++ + S E+ L+D Q
Sbjct: 1265 HAKVSEGDRLRVELAEKASK---LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 542 EKINQQEN-----SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596
E + ++ S + +L+ L++Q++ ++ K E + L +L+ T+K+
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ-Q 655
L +E ++ ++L ++ S E ++E K LQ +++ L L Q Q
Sbjct: 1382 DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441
Query: 656 IKSH--EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
+ S+ + ++ L + +++S + ++++ E ET+ L+ ++A + ++
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 714 HQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
+++ QL +EDL + + + ++ + L + E +R L+ +
Sbjct: 1502 FERQ-------NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
L ED + L AM F + + E+ RL Q + A L++
Sbjct: 1555 LQATEDAKLRLEV--NMQAMKAQFERDLQTRDEQNEEKK--RLLIKQVRELEAELEDERK 1610
Query: 834 SLEFSLESQKQMN---SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890
++ S+K+M DL+ Q E + + E+ + L K + + + E L+E
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE-------LEE 1663
Query: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSET 950
++ + A++ + EK+L+ L ++ Q E+ +++ E
Sbjct: 1664 ARASRDEIFAQS----KESEKKLKSLEAEILQLQEELASSERARRHAEQ----------- 1708
Query: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
E+ E++ I+ + L E L+ A L +E +++ +S +++R +
Sbjct: 1709 ---ERDELADEITNSASGKSALLDEKRRLEARIAQLEEE----LEEEQSNMELLNDRFRK 1761
Query: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE----CTSLCEN 1066
+ D E +++ NA + L ++ K + K +LE + S E
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEA 1821
Query: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAG 1126
+ +LE+ E AKE + E++ + + +++E ++ + + + +
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED-ERRHADQYKEQMEKANARMK 1880
Query: 1127 GLKQEIMTLKEE-------QNKMQKEVNDLLQENEQLMKVMKT 1162
LK+++ +EE + K+Q+E++D + NE L + + T
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVST 1923
Score = 147 bits (370), Expect = 2e-34
Identities = 242/1229 (19%), Positives = 498/1229 (40%), Gaps = 171/1229 (13%)
Query: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250
KP + + +E L + + +L++++ E +L+E E++ + L E + L+
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 1251 QDMQSQEISG--------LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
+++E+ L++ D E + QN+ +Q +Q +L+E
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
E + LQ EK ++ E + + ++ K + E K++ D +L E
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILL----LEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILH 1422
+ + + + V ++ L+E E T EL++ L E L
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ---------ELEKAKRKLDGETTDLQ 1068
Query: 1423 DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP 1482
DQ ++ELQ +D LK L L+ QG L + L + +
Sbjct: 1069 DQ-------IAELQAQIDELK---LQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 1483 DSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETP 1542
+ L +S + L LE + + ++D ++ Q+E T++E
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD---TTAAQQELRTKREQE 1175
Query: 1543 SAPAKGVEE---------LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
A K E ++ + + + +LE+L E++E K +++ +Q L ++ +
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK-ANLEKNKQGLETDNK 1234
Query: 1594 ELDC---LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDL 1650
EL C + +Q +E+E ++KL + E+ +K++ + ++L +EL +LQ +L
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS----EGDRLRVELAEKASKLQN-EL 1289
Query: 1651 SSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKIT 1710
+ S L + E + +K+ S ++ D ++ ++ +Q LNL +I
Sbjct: 1290 DNVSTLLEEAE------KKGIKFAKDAASLESQ---LQDTQELLQEETRQKLNLS-SRIR 1339
Query: 1711 ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIH 1770
+ E+ ++ E E+ +E
Sbjct: 1340 QL-----------EEEKNSLQEQQEEE----------------------------EEARK 1360
Query: 1771 NLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEK 1830
NL+ +V ++ ++D +ESL K+L +L K A +LEK
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 1831 IVGELKKENSDLSEKLEYFSCDHQELL------QRVETSEGLNSDLEMHADKSSREDIGD 1884
L++E DL+ L DHQ + ++ + + L + + A + D +
Sbjct: 1421 TKNRLQQELDDLTVDL-----DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 1885 NVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
A+ ++ + L + L K E + L AD+E + + K + K+ +K
Sbjct: 1476 AEAREKET---KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004
LE+++ + ++ +L EL L+ + MK + + +Q
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE----------RDLQT 1582
Query: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE 2064
+ + +EK LL ++ L+D+ Q L K + L +LE QI NK
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLK--DLEAQIEAANKA 1639
Query: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
++ ++K+ LQA++ DY+ + LE A + E + +++++ L I +L
Sbjct: 1640 RDEVIKQLRKLQAQM--KDYQ-----RELEEARASRDEIFAQSKESEKKLKSLEAEILQL 1692
Query: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
+ + + E+ + H E+E D L D++ N S + ++ + +A +
Sbjct: 1693 QEELASSERARRH-------AEQERDELADEITN-------SASGKSALLDEKRRLEARI 1738
Query: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
L+ ++EE +S E L + ++ Q+ L+ L++ +S ++ +
Sbjct: 1739 AQLEEELEEE--------------QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAV-AALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
A Q++ ++K L+ +L+EL AV + ++A L+ +E+E + R +
Sbjct: 1785 NARQQLERQNKE----LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 2304 EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK 2363
KL R EKK + Q+++ HAD K ++E ++ + E A EA +
Sbjct: 1841 NKLVRR---TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 2364 GEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
L+ +++ T++ GL +V T+++
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKN 1926
Score = 144 bits (364), Expect = 1e-33
Identities = 263/1286 (20%), Positives = 550/1286 (42%), Gaps = 197/1286 (15%)
Query: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
+++RQ+ Q D+E +++K + T+ + + M Q L++ + +QL+ E F +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 459 -KLCRAEQAFQASQIKE--NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQC 515
+ RA A + +++E ++L +EE ++ N +L++ ++ ++A ++++++
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK-------MQAHIQDLEEQ 958
Query: 516 LNQSQNFAEEMKAKNTSQETMLRDLQEKI--NQQENSLTLEKLKLAVADLEKQRDCSQDL 573
L++ + ++++ + + E ++ ++E+I + +NS +++ KL ++ +CS L
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME---DRIAECSSQL 1015
Query: 574 LKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQM 633
++ E+ L+K + + ++S LE + K KEEKT + E EK ++
Sbjct: 1016 AEE-----EEKAKNLAKIRNKQEVMISDLEERLK-----KEEKT-----RQELEKAKRKL 1060
Query: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEV 693
+ E +LQ +I L+ + +++ + E ++ ++ ++ N V+ ++
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI---MDKD 750
ELQ+ D + +K N K Q DL +L+ L E+ +D
Sbjct: 1121 -------AELQE-----DFESEKASRNKAEK------QKRDLSEELEALKTELEDTLDTT 1162
Query: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Q+L + E +++ + K A ++H+ + Q+ A +
Sbjct: 1163 AAQQELRTKRE--QEVAELKKALEEETKNHEAQIQDMRQRHA----------------TA 1204
Query: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
E + +Q+ + A L+ LE N +L + + L Q+K E E K
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETD-------NKELACEVKVLQQVKAESEHKRKKL 1257
Query: 871 EQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930
+ Q A+ S+ +L+ + +AE S L+N +L N E+AE + +
Sbjct: 1258 DAQVQELHAKVSEG-DRLRVE-------LAEKASKLQN-----ELDNVSTLLEEAEKKGI 1304
Query: 931 K--KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQ 988
K K LE L++ Q L + + +K +SS I + E L ++ +E +L +
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 989 EKMNLIQKSESFANYIDEREKSISELSDQYK---QEKLILLQRCEETGNAYEDLSQKYKA 1045
+ + L + +D+ +I L + K ++ L QR EE AY+ L +
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELET 1105
Q++ L L+ + N + + ++ + A+E +AEER++
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS---ISARYAEERDR-------- 1473
Query: 1106 VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE--EQNK-MQKEVNDLLQENEQLMK---- 1158
+E + + + S A L++ + +E QNK ++ ++ DL+ + + K
Sbjct: 1474 ----AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218
+ K+K + + E +R ++E E E Q ++ LEV + A Q E L+
Sbjct: 1530 LEKSKRALEQ-QVEEMRTQLEELEDEL-QATEDAKLRLEV------NMQAMKAQFERDLQ 1581
Query: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278
++ +++E++K L +++ + +LE Q ++ ++ K EID ++
Sbjct: 1582 TRD---EQNEEKKRLLIKQVRELEAELEDERKQ--RALAVASKKKMEIDLKD-------- 1628
Query: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRS--ECITATRKMA 1336
L+ ++ +E+ K LQA+ + EL ++R+ + I A K +
Sbjct: 1629 ----------LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 1337 EEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA-PLDESNSYEHLTL 1395
E+ K L E +IL +L E++ E + EQ LA + S S + L
Sbjct: 1679 EKKLKSL-EAEIL---------QLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 1396 SDK-EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL--STN 1452
+K ++ A+L+E+ QS ++L+D+ + + ++ L L AE S N
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA---ELAAERSAAQKSDN 1785
Query: 1453 LRNFQGDLVKEMQLGLE--EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
R KE++ L+ EG V S + + S+ + +G LEQ +
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATI--SALEAKIGQ---LEEQLEQEAKERAAA 1840
Query: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
N V + + E+F VE+ + Y++ +EK +M
Sbjct: 1841 N--KLVRRTEKKLKEIFMQ-------------------VEDERRHADQYKEQMEKANARM 1879
Query: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSV--TLEMESKLAAEK 1628
+ Q + +E +E ++ R++L NE ++++++ L ++
Sbjct: 1880 K-QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSS 1938
Query: 1629 KQTEQLSLELEVARLQLQGLDLSSRS 1654
++ + L LE A L+L D S++
Sbjct: 1939 SRSGRRQLHLEGASLELSDDDTESKT 1964
Score = 142 bits (357), Expect = 7e-33
Identities = 199/1028 (19%), Positives = 447/1028 (43%), Gaps = 111/1028 (10%)
Query: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV------------------------ 55
IQ+LE QLD+ + +Q+ Q + + EA ++K ++++
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 56 ------ENEKTEGTNLKRENQRLM-----EICESLEKTKQKISHELQVKESQVNFQEGQL 104
E EK + R Q +M E + EKT+Q++ + + + + Q+
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 105 NSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKY 164
+ QI++L+ +L + + EL+ + A+ D +L+ N + + ++ +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGA--LARGDDETLHKNNALKVVRELQAQIAELQ--EDF 1127
Query: 165 EDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKT 224
E K NK ++++ L E++AL+ + A R Q + + +E+T
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 225 PSHLSSNSQRTPIRRDFSASYFSGEQEVTPS---RSTLQIGKRDANSSFFDNSSSPHLLD 281
+H +Q +R+ + + +++ + ++ L+ K+ + + + +L
Sbjct: 1188 KNH---EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD 341
Q+KA+++ R K++ L H K +G ++ +VEL EK L D
Sbjct: 1245 QVKAESEHKRKKLDAQVQEL--HAKVSEG------------DRLRVELAEKASKLQNELD 1290
Query: 342 ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE---FQE 398
+ + ++ K+ L+ +D Q + +L +I++ E+E QE
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
+ ++ + + L+++ + ++++L ++ + +++ L K++L + E Q
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES----LEEAKKKLLKDAEALSQ 1406
Query: 459 KLCRAEQAFQASQIKENELRRSMEEMKKE---NNLLKSHSEQKAREVCHLEAELKNIKQC 515
+L A+ + +N L++ ++++ + + S+ E+K ++ L AE K+I
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 516 LNQSQNFAE-EMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQRDCSQDL 573
+ ++ AE E + K T ++ R L+E + +E K L+ + DL S+D
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS----SKDD 1522
Query: 574 LKKREHHIEQLNDKLSKTEKESKALLSAL--ELKKKEYEELKEEKTLFSCWKSENEKLL- 630
+ K H +E+ L + +E + L L EL+ E +L+ E + K++ E+ L
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM-QAMKAQFERDLQ 1581
Query: 631 ---TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Q E +K L ++ LE L+ ++ + + +E+D ++L +I + D
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARD 1641
Query: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
++L ++ Q K +Q+E+E ++ Q ++ E KL+ L EI+
Sbjct: 1642 E-----VIKQLRKLQAQMK------DYQRELEEARASRDEIFAQSKESEKKLKSLEAEIL 1690
Query: 748 DKDRCYQDLHAEYESLRDLLKSKD--ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQG 805
+ ++L + + R + +D A +TN +S L D++ + A + +
Sbjct: 1691 ---QLQEELASSERARRHAEQERDELADEITNSASGKSAL-LDEKRRLEARIAQL---EE 1743
Query: 806 SMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQK---QMNSDLQKQCE-ELVQIKG 861
+ E+S L D+ K + +VD+L L +++ Q + + ++Q E + ++K
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTL----QVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 862 EIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVE 921
+++E + ++ ++ +I +L+E A + EK+L+ + +VE
Sbjct: 1800 KLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859
Query: 922 TEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN-GTLK 980
E+ + K+ +K+L+ E E ++ +RE+++ T+ N G +
Sbjct: 1860 DERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSR 1919
Query: 981 EINASLNQ 988
E++ N+
Sbjct: 1920 EVSTLKNR 1927
Score = 127 bits (318), Expect = 2e-28
Identities = 201/978 (20%), Positives = 413/978 (42%), Gaps = 110/978 (11%)
Query: 9 KEGLPTRALQKIQ-ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN--- 64
KE + L+K + +L+G+ L+ + + Q Q+D L+ L K++++++ G +
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETL 1104
Query: 65 -----------LKRENQRLMEICES-------LEKTKQKISHELQVKESQVNFQEGQLNS 106
L+ + L E ES EK K+ +S EL+ ++++ E L++
Sbjct: 1105 HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL---EDTLDT 1161
Query: 107 GKKQIE---KLEQELKRCKSELER--SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG 161
Q E K EQE+ K LE AQ D+ +++ Q
Sbjct: 1162 TAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEEL------SEQLEQA 1215
Query: 162 SKYEDLKEKYNKEVE-ERKRLEAEVKALQAKKASQTLPQ-----------ATMNHRDIAR 209
+++ EK + +E + K L EVK LQ KA + A ++ D R
Sbjct: 1216 KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 210 HQASSSVFSWQQE-KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKR---D 265
+ + Q E S L +++ I+ F+ S E ++ ++ LQ R +
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIK--FAKDAASLESQLQDTQELLQEETRQKLN 1333
Query: 266 ANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKA 325
+S + L + + + +E R + + L LQ + K +V+ LE+A
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 326 KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSL 385
K +L++ + L++ L YD+ L+Q+L LT DL QRQ A +L
Sbjct: 1394 KKKLLKDAEALSQ---RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS----NL 1446
Query: 386 EQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD----- 440
E+K K+ ++ EE S R + D+ + + + T+ L A+ + L+A+ +
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 441 -KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
+L + + L ++ ++ + + E++ +A + + E+R +EE++ E L++ + K
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE---LQATEDAKL 1563
Query: 500 REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA 559
R LE ++ +K F +++ ++ E R L +++ + E L E+ + A
Sbjct: 1564 R----LEVNMQAMK------AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLF 619
+A K++ + LK E IE N + K+ + L + ++ ++E EE + +
Sbjct: 1614 LAVASKKK--MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
E+EK L +E+E LQ ++ E R E +R+ L+ EI
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERAR--------------RHAEQERDELADEI 1717
Query: 680 RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
N + ++ E ++L Q + E +++ E+ N + + L QV+ L +L
Sbjct: 1718 TN--SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL--QVDTLNAEL 1773
Query: 740 -------QLLSNEIMDKDRCYQDLHAEYESLRDLLKSK-DASLVTNEDHQRSLLAFDQQP 791
Q N +R ++L A+ + L +KSK A++ E L +Q
Sbjct: 1774 AAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Query: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK 851
A + AN + + + E ++ + +++ + +++ ++ K+ + ++
Sbjct: 1834 AKERAAANKLVRR--TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEE 1891
Query: 852 QCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
+ + +++ L A + ++ E S ++L+ + L +
Sbjct: 1892 EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGA 1951
Query: 912 ELQLLNDKVETEQAEIQE 929
L+L +D E++ +++ E
Sbjct: 1952 SLELSDDDTESKTSDVNE 1969
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 195 bits (495), Expect = 7e-49
Identities = 355/1653 (21%), Positives = 692/1653 (41%), Gaps = 243/1653 (14%)
Query: 1415 QSEHKILHDQHCQMSSKMS-----ELQTYVDSLKA-ENLVLSTNLRNFQGDLVKEMQLGL 1468
Q E +L + H Q +++S EL Y + ++ ENL+ + DL K ++
Sbjct: 233 QHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM-- 290
Query: 1469 EEGLVPSLSSSCVPDSSSLSSLGDS--SFYRALLEQTGDMSLLS------NLEGAVSANQ 1520
+ + L V + + L D + L D +L N+E +
Sbjct: 291 -QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEE 349
Query: 1521 CSVDEVFCSSLQ------EENLTRKETPSAPAKGVEELESLC--------EVYRQSLEKL 1566
C ++ CS LQ + +T KE A + VEE+ L E+ R S
Sbjct: 350 CENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQ 409
Query: 1567 EEKMESQGIMKNKEIQELEQ---LLSSERQELDCLRKQYLSENEQWQQKLT-SVTLEMES 1622
+ + + I+ LE+ LLS E++EL + +E E + T ++L+ E
Sbjct: 410 DNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSEL 469
Query: 1623 ---KLAAEKKQ-------TEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCD 1672
+L E K+ +E+ +L E+ L Q + + +L D Q +S
Sbjct: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI- 528
Query: 1673 ISKEHTSETTERTPKHDVHQICDK--DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
ISK E K VHQ+ D D ++L++ EK+ ++ + ++ D
Sbjct: 529 ISKLKQDLNDE---KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI----HNLQLRVKETSNENLRL 1786
D+ S E S +S N + N+E++ + L + + SN N +
Sbjct: 586 ENLV--DQLNKSQE--SNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD 641
Query: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL 1846
++++R+ +V +L + EL+ L E L+K+ ++K EN L
Sbjct: 642 T-LLKEREAEVRNLKQNLSELEQ---LNE-----------NLKKVAFDVKMENEKL---- 682
Query: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHAD---KSSREDIGDNVAKVNDSW-KERFLDVEN 1902
+C+ ++ ++E N+ L + + ++ + + G+ A++ W K+R L+ N
Sbjct: 683 -VLACE--DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL--CWAKKRLLEEAN 737
Query: 1903 -------ELSRIRSEKAS---IEHEALYL---EADLEVVQTEKLCLEKDNENKQKVIVCL 1949
ELS R+ S +EHE L + D+E+ + +K + D ++K+
Sbjct: 738 KYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKET----- 792
Query: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
++ LS E+ QL ++KK +++L E+ + +EL+ + S+ L ++ +
Sbjct: 793 KDVLSSSLEEQKQLT---QLINKKEIFIEKLKERSSKLQEELDKY-SQALRKNEILRQTI 848
Query: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK--------CELENQIAQL 2061
+EK L ++ ++ HLQE+L+ L ++ + EL ++++QL
Sbjct: 849 EEKDRSLGSMK-------EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL 901
Query: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA-----LRLSSTQ----- 2111
N KE L +E + Q + + + K+ + ++L+ E EF + + TQ
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 2112 -EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ 2170
EE+ L++ IE++ K QLH E+ ++ + +N + + + ++ E
Sbjct: 962 DEEIKSLQKTIEQI--------KTQLH--EERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
Query: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ--------IQEK 2222
+L SKAE E L I+E +K+ ++L + + L+K IQ+K
Sbjct: 1012 DL-------SKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064
Query: 2223 QGQLSELDKLLSSF---KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279
++ L +SS + ++ ++Q + E K +L + +E +
Sbjct: 1065 DLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFA-VLNEKTRENSHLKTEYHKMM 1123
Query: 2280 EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
+I+ A E +L +E +L E + + + L + ++E + D L + +
Sbjct: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI--IREKDIEIDALSQKCQ 1181
Query: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399
L L+ + T E + + N E+ + K++ + + + V+T ++ +
Sbjct: 1182 TLLAVLQTSSTGNEAGGVNS-NQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
Query: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
+LQ+E ++ +++S + LQ +Q E++ T ++ +L ++ + L N
Sbjct: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
Query: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
++ K +S Q+ L Q + L +K+ VL S L QE+E+ ++ L++
Sbjct: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE--VLSESSELLQQELEELRKSLQE 1358
Query: 2520 KDEEISRLK---NQIQDQEQLVSKLS-----QVEGEHQLWKEQNLELRNLTVE----LEQ 2567
KD I L+ +++ D S+L Q + E + KE+ L+ L E ++
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 2568 KIQVLQSKNASLQDTL---EVLQSSYKNLENELELTKMD----KMSFVEKVNKMTAKETE 2620
K L S N + + + E+L+ + NL+ + + +MD K + V KETE
Sbjct: 1419 KSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETE 1478
Query: 2621 LQR-----------------EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Q E H M +K ++ L ++ GEL LL +KS +++
Sbjct: 1479 YQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538
Query: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
E ++ +L + + +V + + + + R ++ ++ + LL++ Y
Sbjct: 1539 TVVFQQERDQVMLALKQKQMENTALQNEV-QRLRDKEFRSNQELERLRNHLLESEDSYT- 1596
Query: 2724 EIQTYREKLTSKEECLSSQK----LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK 2779
RE L +++ +K LE L+ SS N S +A+ Q+ E L++ K
Sbjct: 1597 -----REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQV-ESLQEQLNVVSK 1650
Query: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQ-EKQKTGTVMDTKVDE 2838
++ + +Q ++K S L+ E Q+E + +A+ EKQK +
Sbjct: 1651 QRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQK----------Q 1700
Query: 2839 LTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSR 2898
L E K+ E LE K E LD+ + L S +L + ++ E Q+ L +Q+
Sbjct: 1701 LIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEEL----KRQNEL 1756
Query: 2899 GSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGK 2931
+L V +K+L S N + GK
Sbjct: 1757 RQEMLDDV-----------QKKLMSLANSSEGK 1778
Score = 189 bits (480), Expect = 4e-47
Identities = 338/1624 (20%), Positives = 691/1624 (42%), Gaps = 182/1624 (11%)
Query: 1398 KEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN-- 1455
+EV+ + + K +++ H IL ++ ++ ++L+ ++ + + ST+ RN
Sbjct: 43 EEVEAELPDSRTK--EIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQL 100
Query: 1456 ----FQGDLVKEMQLGLEEGLVPSLSSSC-------VPDSSSLSSLGDSSFYRALLEQTG 1504
+ +K Q+ L++ L+ S++ VP +++ SS +
Sbjct: 101 QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160
Query: 1505 DMSLLSNLEGAVSANQCSVDEVFCSSLQEE-NLTRKETPSAPAKGVEELES--LC----- 1556
DM + N+ S +EV S L+ E R ++ A+G + + +C
Sbjct: 161 DMDFGDIISSQQEINRLS-NEV--SRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI 217
Query: 1557 --EVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLT 1614
E+ + +++++ +++N Q+L ++ R+EL ++ + E E Q+
Sbjct: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEER-IEELENLLQQGG 276
Query: 1615 SVTLEME-SKLAAEKKQTEQLSLELEVARLQLQGL-----DLSSRSLLGIDTEDAIQGRN 1668
S +E + SK+ +K + L +E + +++ L D++ + + D ++
Sbjct: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
Query: 1669 ESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKI-TETGAVKPTGECSGEQSP 1727
E ++ K E E Q D + E+I ++ +V+ S
Sbjct: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396
Query: 1728 DTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLL 1787
N Q +S L ++ + ++ LQ+ + + +NE
Sbjct: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE----Y 452
Query: 1788 HVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847
VI+ + SL +E+ +L L +E +L I E E ++ E+++ + E +
Sbjct: 453 EVIKSTATRDISLDSELHDLRLNLEAKEQELNQSIS---EKETLIAEIEELDRQNQEATK 509
Query: 1848 YFSCDHQELLQRVETSEGLNSDLEMHADKSSR-----EDIGDNVAKVNDSWKERFLDVEN 1902
+ +L ++ + + S L+ + + ED ++ K D KE+ + E
Sbjct: 510 HMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEV 569
Query: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
L+ + K +E + L L Q + ++K+N ++ I EEELS + +E Q
Sbjct: 570 ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQ 629
Query: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022
+ + K T L + +++ Q L S + ++ +VK + E L D
Sbjct: 630 SLNQDSNSNFKDTLLKEREAEVRNLKQNL-SELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 2023 VSELLKDKTHLQEKLQSLEKDS--QALSLTKCELENQIA--------QLNKEKELLVKES 2072
V L++ +L SLEK++ + L + K E+E ++ + NK ++ + + S
Sbjct: 689 VRHQLEECLAGNNQL-SLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELS 747
Query: 2073 ESLQARLSESDYE-----KLNVSKALEAALVEKG---------EFALRLSSTQEEVHQLR 2118
+ S E KLN K +E A ++K E LSS+ EE QL
Sbjct: 748 NARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLT 807
Query: 2119 RGIEKLRVRIEADEKKQLHIAEKL---KERERENDSLKDKVENLEREL-QMSEENQELVI 2174
+ I K + IE +++ + E+L + R+N+ L+ +E +R L M EEN L
Sbjct: 808 QLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHL-- 865
Query: 2175 LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 2234
+ E+E L+ EE +R+ V D TL S E L ++ + L++ +
Sbjct: 866 ------QEELERLR---EEQSRTAPV--ADPKTLDSVTE-LASEVSQLNTIKEHLEEEIK 913
Query: 2235 SFKSLLEEKEQAEIQI---KEESKTAVEMLQNQLKELNEAVAALCGDQ-EIMKATEQSLD 2290
+ ++E++ Q+++Q+ +E K ++ + Q +++N L ++ E +K+ +++++
Sbjct: 914 HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Query: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL-----EREL 2345
+ H+ R I+ + + + K Q ++ SE H DL K E L EREL
Sbjct: 974 QIKTQLHEERQDIQTDNSDIFQETKVQSLNIE--NGSEKH-DLSKAETERLVKGIKEREL 1030
Query: 2346 EIARTNQEHAALEA---ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQ 2402
EI N+++ +L + SK EV L I+ + LE+ + R + T ++
Sbjct: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ-----QKDLEIQALHARISSTSHTQDVV 1085
Query: 2403 KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM----------LQTQLKELNE 2452
Q+++ + +L EK +E +K + M++ LQ + K+L+
Sbjct: 1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLST 1145
Query: 2453 RVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG------- 2505
R + + Q+ + QNLS + ++E L Q + + VLQ+S G
Sbjct: 1146 RFES--SGQDMFRETIQNLSRIIREKDIEIDALSQ---KCQTLLAVLQTSSTGNEAGGVN 1200
Query: 2506 ------LIQEVEDGKQKLEK----KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN 2555
L+QE + KQ+++K K + ++ ++N + QL +L Q++ + + + N
Sbjct: 1201 SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNN 1260
Query: 2556 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN--ELELTKMDKMS-FVEKVN 2612
+L+ L Q + ++K + L +Q S L N +L L K+D +S + +
Sbjct: 1261 SKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS 1320
Query: 2613 KMTAKETE-LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN 2671
+T + E L+ E+ +++EL ++ E + E + ++ + +L +
Sbjct: 1321 LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380
Query: 2672 SELKK----SLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEI-- 2725
SEL++ D K EK+ +++ + E L + K LL +N+ + ++
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLI----KAKSDQLLSSNENFTNKVNE 1436
Query: 2726 -QTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM--------- 2775
+ R+ +T+ +E + +++I LK E++ + + + L++T M
Sbjct: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
Query: 2776 --------DNLKYVNQLKKENERAQ-GKMKLLIKSCKQLEEEKEILQKELSQLQ-AAQEK 2825
+ QL KE E+ + G++ L+ + K ++E+ + Q+E Q+ A ++K
Sbjct: 1497 EFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQK 1556
Query: 2826 QKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHE----KLEKAKEML 2881
Q T + +V L + + LE E D Y ++ E KL K +L
Sbjct: 1557 QMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVL 1616
Query: 2882 ETQV 2885
E ++
Sbjct: 1617 EEKL 1620
Score = 187 bits (475), Expect = 1e-46
Identities = 373/1837 (20%), Positives = 743/1837 (40%), Gaps = 249/1837 (13%)
Query: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
+ W GL + Q + ++ G L L Q F D L ++ + ++ + +T+
Sbjct: 1 MSSWLGGLGSGLGQSLGQVGGSLASLTG--QISNFTKDMLMEGTEEVEAELPDSRTKEIE 58
Query: 65 -----LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119
L+ EN+RL ++C LE+ + + E+Q+K+ +++ QL + +I L+
Sbjct: 59 AIHAILRSENERLKKLCTDLEEKHE--ASEIQIKQQSTSYR-NQLQQKEVEISHLKARQI 115
Query: 120 RCKSELERSQQAAQSADVSLN-PCNTPQKIFTTPLT--PSQYYSGS-KYEDL---KEKYN 172
+ +L + Q AAQS P T F ++ PS ++ + D+ +++ N
Sbjct: 116 ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175
Query: 173 KEVEERKRLEAEV----------KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
+ E RLE+EV KA + Q+ N + S + Q E
Sbjct: 176 RLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHE 235
Query: 223 KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDA----NSSFFDNSSSPH 278
+ + + T I R E+ + + LQ G S ++ +
Sbjct: 236 MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQ 295
Query: 279 LLDQLKAQN----QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK 334
+L K ++ ++L +KI ++ +L E + + + ++ QL +EK ++ + E E
Sbjct: 296 VLQIEKVESTKKMEQLEDKIKDINKKLSSAENDR--DILRREQEQLNVEKRQI-MEECEN 352
Query: 335 VLNKCRDELVRTTAQYDQASTKYTALEQ--------KLKKLTED-------LSCQRQNAE 379
+ +C Q D + K L Q +L++ D LS Q+
Sbjct: 353 LKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNS 412
Query: 380 SARCSLEQKIK----EKEKE-FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV 434
A +L+ K++ EKEK +E Q S L+ E +K+ T+++ +H++
Sbjct: 413 LAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDL 472
Query: 435 ------LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF-----QASQIKENELRRSMEE 483
+ EL++ S K+ L +EE ++ A + Q S+ ++NE + +
Sbjct: 473 RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSK-QQNEGDSIISK 531
Query: 484 MKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK 543
+K++ N K Q + + EL K+ L QS+ ++ E + +L ++
Sbjct: 532 LKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQ 591
Query: 544 INQ-QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKT-----EKESKA 597
+N+ QE++++++K L + + +Q + ++L + R ++ LN + KE +A
Sbjct: 592 LNKSQESNVSIQKENLELKEHIRQNE--EELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Query: 598 LLSALELKKKEYEELKE--EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQ 655
+ L+ E E+L E +K F K ENEKL+ E + + LE CL
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDV-KMENEKLVLACEDVR-------HQLEECLAGNN 701
Query: 656 IKSHEYNERVRTLEMDRENLSVE------------------IRNLHNV--LDSKSVEVET 695
S E N V TL+M++ + E I L N L++ ++++E
Sbjct: 702 QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH 761
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCL-----------------KTSQLTGQVEDLEHK 738
+ L ++L QK + + +K IE M + +QL + E K
Sbjct: 762 EHL--IKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK 819
Query: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED-------------HQRSLL 785
L+ S+++ ++ Y + E LR ++ KD SL + ++ ++S
Sbjct: 820 LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
Query: 786 AFDQQPAMHHSFANIIGEQGSMPSERSECRLE--------ADQSPKNSAILQN------R 831
A P S + E + + + E DQ+ +LQ+
Sbjct: 880 APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939
Query: 832 VDSLEFSLESQKQMNSDLQKQCEE--------LVQIKGEIEENLMKAEQMHQSFVAETSQ 883
+D + E ++ L + +E + QIK ++ E + + ET
Sbjct: 940 MDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKV 999
Query: 884 RISKLQEDTSAHQNVVAET---LSALENKEKELQLLNDK-----VETEQAEIQELKKSNH 935
+ ++ + H AET + ++ +E E++LLN+K + +Q E+ K
Sbjct: 1000 QSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQ 1059
Query: 936 LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
+++ E+Q L +S ++ L +++++ E + + +E +L
Sbjct: 1060 IIQQKDLEIQALHARIS-STSHTQDVVYL-QQQLQAYAMEREKVFAVLNEKTRENSHLKT 1117
Query: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY--EDLSQKYKAAQEKNSKL 1053
+ + + +E ++ +L D+ K+ L R E +G E + + +EK+ ++
Sbjct: 1118 EYHKMMDIVAAKEAALIKLQDENKK----LSTRFESSGQDMFRETIQNLSRIIREKDIEI 1173
Query: 1054 ECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS- 1112
+ L +C +L + EA +F L ++ Q + E QQ + +
Sbjct: 1174 DALSQKCQTLLAVLQTS-STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTV 1232
Query: 1113 -EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
M + E L+ +++ + +K+Q + L+Q EQ +TK + E
Sbjct: 1233 QNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQ----NETKLKNFGQEL 1288
Query: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
+++S+ + CN K + ++ IS +A L+ ++ + K + +
Sbjct: 1289 AQVQHSIGQ------LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
Query: 1232 ECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC 1291
E LQ EL+ +R L+ + QE + I A + HE + S+
Sbjct: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK------ 1396
Query: 1292 SLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILND 1351
L+ + L +L K ++L K + + N++ + + + + V L + IL
Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456
Query: 1352 DSGLLHGE---LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408
D G L GE +VE G E Q L E+N + L +KE + H ++
Sbjct: 1457 DIGKLKGENEKIVETYRGKETEYQ----------ALQETNMKFSMMLREKEFECH--SMK 1504
Query: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
EK L+ + ++L ++ + ++++L V S++ + +V FQ + ++ L L
Sbjct: 1505 EKALAFE---QLLKEKEQGKTGELNQLLNAVKSMQEKTVV-------FQQER-DQVMLAL 1553
Query: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528
++ + + + + + L D F R+ E L L + ++ S
Sbjct: 1554 KQKQMENTAL-----QNEVQRLRDKEF-RSNQE-------LERLRNHLLESEDSYTREAL 1600
Query: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL 1588
++ E RK+ K V ++ Q+ ++E E ++ + + QL
Sbjct: 1601 AAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLS 1660
Query: 1589 SSERQ----ELDCLRKQYLSENEQWQQK-LTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643
S+ Q L Q + E+ Q ++K + S LE + +L AE K+ + +LE +V L
Sbjct: 1661 VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAE-NLEGKVISL 1719
Query: 1644 QLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680
Q + LD ++ +L D+ E D+ +E E
Sbjct: 1720 Q-ECLDEANAAL------DSASRLTEQLDVKEEQIEE 1749
Score = 182 bits (463), Expect = 3e-45
Identities = 384/1870 (20%), Positives = 770/1870 (41%), Gaps = 303/1870 (16%)
Query: 972 LTQENGTLKEINASLNQE----KMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
L EN LK++ L ++ ++ + Q+S S+ N + ++E IS L + + I LQ
Sbjct: 64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHL-----KARQIALQ 118
Query: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
+ L + AAQ S T+ + + AF + +F
Sbjct: 119 ---------DQLLKLQSAAQSVPSGAGV---PATTASSSFAYGISHHPSAFHDDDMDFGD 166
Query: 1088 KLAFAEERNQ--NLMLELET-------VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE 1138
++ +E N+ N + LE+ + Q +++ TDN + +SE L+ I LK
Sbjct: 167 IISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSD--QSEICKLQNIIKELK-- 222
Query: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLE-SEPIRNSVKERESERNQC-NFKPQMDL 1196
QN+ Q+ + +++ M V++ H+ + E S R + + E + N Q
Sbjct: 223 QNRSQE-----IDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
Query: 1197 EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ 1256
V E L +++ +++ ++ +++ ES K+ E L+ +++ I L ++ +
Sbjct: 278 GVIETDL----SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAE----NDR 329
Query: 1257 EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA--EK 1314
+I + +++ E++ I E + + + LQ S + + E E+I + E
Sbjct: 330 DILRREQEQLNVEKRQIM--EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV 387
Query: 1315 YELVTELNDSRSECITAT-----RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
+ L L+D+ +E + + +AE+ KL +++L + LL
Sbjct: 388 FRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLL------------- 434
Query: 1370 GEQPNEQHPVSLAPLDESNSYEHL-TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428
Q E+ +SL L+ N YE + + + +++ + +EL + L+L+++ + L+ Q
Sbjct: 435 -SQEKEELQMSLLKLN--NEYEVIKSTATRDISLD-SELHDLRLNLEAKEQELN----QS 486
Query: 1429 SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLS 1488
S+ L ++ L +N + ++ + L K+ G + ++ L + +
Sbjct: 487 ISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG--DSIISKLKQDLNDEKKRVH 544
Query: 1489 SLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKG 1548
L D M + L+ V + EV +L + +LT+++
Sbjct: 545 QLEDDK-----------MDITKELD--VQKEKLIQSEV---ALNDLHLTKQKLEDKVENL 588
Query: 1549 VEEL----ESLCEVYRQSLEKLE---EKMESQGIMKNKEIQELEQ---------LLSSER 1592
V++L ES + +++LE E + E ++N+ +Q L Q LL
Sbjct: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648
Query: 1593 QELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
E+ L KQ LSE EQ + L V ++ K + E+L L E R QL
Sbjct: 649 AEVRNL-KQNLSELEQLNENLKKVAFDV-------KMENEKLVLACEDVRHQL------- 693
Query: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
E+ + G N+ + K ET + ++C A++ L + K +T
Sbjct: 694 --------EECLAGNNQ-LSLEKNTIVETLKMEKGEIEAELCW--AKKRLLEEANKYEKT 742
Query: 1713 GAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772
E S ++ +T+ Q E + +L N M+ +++I +
Sbjct: 743 -----IEELSNARNLNTS-------ALQLEHEHLIKL-----NQKKDMEIAELKKNIEQM 785
Query: 1773 QLRVKETSN-------ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE-- 1823
KET + E +L +I ++ +E L +L +L Q + K E
Sbjct: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYS-QALRKNEIL 844
Query: 1824 --ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1881
E ++ +G +K+EN+ L E+LE + Q V + L+S E+ ++ S
Sbjct: 845 RQTIEEKDRSLGSMKEENNHLQEELERLR-EEQSRTAPVADPKTLDSVTELASEVSQLNT 903
Query: 1882 IGDNVAKVNDSWKERFLDVENE-----LSRIRSEKASIEHEALYLEADLEVVQTEKLCLE 1936
I +++ + ++ ++ +N+ L ++ +K ++ E Y + T+ L LE
Sbjct: 904 IKEHLEE-EIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD-EFRYQHEQMNATHTQ-LFLE 960
Query: 1937 KDNENK--QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
KD E K QK I ++ +L ER ++ + + ++T E EK ++
Sbjct: 961 KDEEIKSLQKTIEQIKTQLH---EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
Query: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT-HLQEKLQSLEKDSQALS--LTK 2051
+ I+ E E+K E +L+ + +L KD+ L + +Q + + QAL ++
Sbjct: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
Query: 2052 CELENQIAQLNKEKELLVKESESLQARLSE---------SDYEKL-NVSKALEAALVEKG 2101
+ L ++ + E E + A L+E ++Y K+ ++ A EAAL++
Sbjct: 1078 TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ 1137
Query: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER 2161
+ +LS+ E G + R I+ +++ ++E++ E D+L K + L
Sbjct: 1138 DENKKLSTRFES-----SGQDMFRETIQ-------NLSRIIREKDIEIDALSQKCQTLLA 1185
Query: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
LQ S E +++ N E+ + ++++ + ++ ++ ++T ++ + Q+QE
Sbjct: 1186 VLQTSSTGNEAGGVNS-NQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQE 1244
Query: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI 2281
+ QL + S S L+ IQ E+++T ++ +L ++ ++ LC +++
Sbjct: 1245 ELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDL 1304
Query: 2282 MKATEQSLDPPI-----------------------EEEHQLRNSIEKLRARLEADEKKQL 2318
+ + P + E L+ +E+LR L+ +
Sbjct: 1305 LLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD---- 1360
Query: 2319 CVLQQLKESEHHADLLKGRVENLER------ELEIARTNQEHAALEA------------- 2359
++ L+E+ H LER + EI + ++ L+
Sbjct: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
Query: 2360 ----------ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS 2409
N E E L+ + + + + LE+D+ ++ E E + + ++
Sbjct: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
Query: 2410 ELEIINSSFENILQEKEQEKVQMKEKSSTAMEML----QTQLKELNERVAALHNDQE--- 2462
L+ N F +L+EKE E MKEK+ ++L Q + ELN+ + A+ + QE
Sbjct: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
Query: 2463 -----------ACKAKEQN---LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ 2508
A K K+ L ++V+ L ++ + Q L+ +N+ + + S
Sbjct: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Query: 2509 EVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE-GEHQLWKEQNLELRNLTVELEQ 2567
ED + KL KK + +E+LVS + +E HQ + L V +Q
Sbjct: 1601 AAEDREAKLRKKVTVL---------EEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQ 1651
Query: 2568 KIQVLQSKNASLQDTLEVLQSSYKNLENELE-LTKMDKMSFVEKVNKMTAKETELQREMH 2626
+ + + S Q+ ++ S NL+ LE + +K + ++ K E ++
Sbjct: 1652 RDETALQLSVS-QEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAE 1710
Query: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686
+ K LQE L E N L E++ ++Q++EL +N ++ LD + K +
Sbjct: 1711 NLEGKVISLQECLD-EANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLM 1769
Query: 2687 ----EKEGKV 2692
EGKV
Sbjct: 1770 SLANSSEGKV 1779
Score = 175 bits (443), Expect = 7e-43
Identities = 386/1919 (20%), Positives = 805/1919 (41%), Gaps = 294/1919 (15%)
Query: 726 SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT-----NEDH 780
+ LTGQ+ + + + E ++ + E E++ +L+S++ L E H
Sbjct: 24 ASLTGQISNFTKDMLMEGTEEVEAE-LPDSRTKEIEAIHAILRSENERLKKLCTDLEEKH 82
Query: 781 QRSLLAFDQQPAMHHS--------FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832
+ S + QQ + + +++ Q ++ + + + A P + +
Sbjct: 83 EASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTA 142
Query: 833 DS-LEFSLESQKQMNSDLQKQCEELVQIKGEI-----EENLMKAEQMHQSFVAETSQRIS 886
S + + D +++ + EI E + +++E H +A+TS
Sbjct: 143 SSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTS---- 198
Query: 887 KLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL 946
K Q ++ Q+ + + L+N KEL+ Q QE+ H
Sbjct: 199 KAQGTDNSDQSEICK----LQNIIKELK---------QNRSQEIDDHQH----------- 234
Query: 947 LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDE 1006
E L+ + +++R EEL+ ++E+ L Q +I E+ + I E
Sbjct: 235 --EMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVI---ETDLSKIYE 289
Query: 1007 REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE-------KNSKLECLLNE 1059
+K+I L + EK+ ++ E+ + +D+++K +A+ + +L +
Sbjct: 290 MQKTIQVL----QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQ 345
Query: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE--MTDN 1117
CEN K E +L+ + K+ K + ++ + +V++ R + ++D
Sbjct: 346 IMEECENLKLECSKLQPSAVKQSDTMTEK--------ERILAQSASVEEVFRLQQALSDA 397
Query: 1118 QN-----NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-MKVMKTKHECQNLES 1171
+N +S ++ L ++ + LK ++KE + L QE E+L M ++K +E + ++S
Sbjct: 398 ENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS 457
Query: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
R+ + E + N LE KE L+ ++ L A + + + QE+ K
Sbjct: 458 TATRDISLDSELHDLRLN------LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHM 511
Query: 1232 ECLQHEL--QTIRGDLETSNL-QDMQSQE--ISGLKDCEIDA-------EEKYISGPHEL 1279
++ +L Q GD S L QD+ ++ + L+D ++D +EK I L
Sbjct: 512 ILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL 571
Query: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEV 1339
+ L+ ++ +++LN+ ++ +Q E EL + R+ EE+
Sbjct: 572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI-----------RQNEEEL 620
Query: 1340 GKLLNEV-KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK 1398
++ NE+ + LN DS + + + E N + +L+ L++ N E+L
Sbjct: 621 SRIRNELMQSLNQDS---NSNFKDTLLKEREAEVRNLKQ--NLSELEQLN--ENLKKVAF 673
Query: 1399 EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQG 1458
+V+M E ++ L+ + L + + E T V++LK E + L +
Sbjct: 674 DVKM---ENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK 730
Query: 1459 DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMS---LLSNLEGA 1515
L++E E + LS++ ++S+L + + L Q DM L N+E
Sbjct: 731 RLLEEANK--YEKTIEELSNARNLNTSALQLEHE---HLIKLNQKKDMEIAELKKNIE-Q 784
Query: 1516 VSANQCSVDEVFCSSLQEEN-LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME--S 1572
+ + +V SSL+E+ LT+ + + E E ++ KL+E+++ S
Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQL---------INKKEIFIEKLKERSSKLQEELDKYS 835
Query: 1573 QGIMKNK----EIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSV----TLEMESKL 1624
Q + KN+ I+E ++ L S ++E + L+++ L + Q + V TL+ ++L
Sbjct: 836 QALRKNEILRQTIEEKDRSLGSMKEENNHLQEE-LERLREEQSRTAPVADPKTLDSVTEL 894
Query: 1625 AAEKKQTEQLS--LELEVARLQ--LQGLDLSSRSLLGIDTE-----DAIQGRNESCD--- 1672
A+E Q + LE E+ Q ++ + S LL E D + ++E +
Sbjct: 895 ASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATH 954
Query: 1673 ----ISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPD 1728
+ K+ ++ ++T + Q+ ++ +QD+ D I + V+ +G + D
Sbjct: 955 TQLFLEKDEEIKSLQKTIEQIKTQLHEE--RQDIQTDNSDIFQETKVQSLNIENGSEKHD 1012
Query: 1729 TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENL-RLL 1787
+ + E +G E E+ L N+++I +L ++ + S + + +L
Sbjct: 1013 LS-KAETERLVKGIKERELEIK------------LLNEKNI-SLTKQIDQLSKDEVGKLT 1058
Query: 1788 HVIEDRDRKVESLLNEMKELDSKLHLQEV-QLMTKIEA-CIELEKI---VGELKKENSDL 1842
+I+ +D ++++L + S H Q+V L +++A +E EK+ + E +ENS L
Sbjct: 1059 QIIQQKDLEIQAL---HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL 1115
Query: 1843 SEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVEN 1902
K EY +++ V E L+ K S + S ++ F +
Sbjct: 1116 --KTEY-----HKMMDIVAAKEAALIKLQDENKKLS--------TRFESSGQDMFRETIQ 1160
Query: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
LSRI EK D+E+ + C Q ++ L+ +S N+
Sbjct: 1161 NLSRIIREK------------DIEIDALSQKC--------QTLLAVLQ-----TSSTGNE 1195
Query: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022
G S + L Q +K+K++ +++E + + + +Q + E + E L L +
Sbjct: 1196 AGG---VNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
Query: 2023 V-------SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
V S+L D T L + + E + ++++ I QL K+LL+ + + +
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDII 1312
Query: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSST-QEEVHQLRRGIEKLRVRIEADEKK 2134
+LS + L ++ E K E S Q+E+ +LR+ +++ I ++
Sbjct: 1313 SPQLSSAS---LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQEN 1369
Query: 2135 QLHIAEKL--------KERERENDSLK------DKVENL--ERELQMSEENQELVILDAE 2178
+++ + KE E+ + +K D ++ L E++L + ++ +L+ +
Sbjct: 1370 NHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN 1429
Query: 2179 --NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
N E E L+ + + + + E+D+ L+ E E + + + K+ + L + F
Sbjct: 1430 FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKF 1489
Query: 2237 KSLLEEKEQAEIQIKEESKTAVEML----QNQLKELNEAVAALCGDQEIMKATEQSLDPP 2292
+L EKE +KE++ ++L Q + ELN+ + A+ QE +Q D
Sbjct: 1490 SMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV 1549
Query: 2293 I-------EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
+ E L+N +++LR + ++ + L ESE E+ E +L
Sbjct: 1550 MLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL 1609
Query: 2346 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2405
T E + + N+ +E + +SL+ +L+VV+ +++ +L Q
Sbjct: 1610 RKKVTVLEEKLVSSSNA---MENASHQASVQVESLQE-QLNVVS--KQRDETALQLSVSQ 1663
Query: 2406 ERISELEIINSSFENILQEKEQEKVQMK----EKSSTAMEMLQTQLKELNERVAALHNDQ 2461
E++ + + ++ + +L+ +QE+ M EK + + + L +V +L
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL 1723
Query: 2462 EACKAKEQNLSSQVECLELEKAQL----------LQGLDEAKNNYIVLQSSVNGLIQEV 2510
+ A + S E L++++ Q+ + LD+ + + L +S G + +V
Sbjct: 1724 DEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
Score = 160 bits (404), Expect = 2e-38
Identities = 311/1509 (20%), Positives = 622/1509 (41%), Gaps = 289/1509 (19%)
Query: 18 QKIQELEGQLDKLKKEKQ------QRQFQLDS--------LEAALQKQKQKVENEKTEGT 63
Q+ +EL+ L KL E + R LDS LEA Q+ Q + ++T
Sbjct: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIA 495
Query: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
++ +++ E + + K ++S + +S ++ + LN KK++ +LE +
Sbjct: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
Query: 124 ELERSQQAAQSADVSLNPCN-TPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
EL+ ++ ++V+LN + T QK+ K E+L ++ NK E ++
Sbjct: 556 ELDVQKEKLIQSEVALNDLHLTKQKL------------EDKVENLVDQLNKSQESNVSIQ 603
Query: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
E L+ H+ N
Sbjct: 604 KENLELK------------------------------------EHIRQN----------- 616
Query: 243 ASYFSGEQEVTPSRSTL-QIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301
E+E++ R+ L Q +D+NS+F D LL + +A+ + L+ ++ELE
Sbjct: 617 ------EEELSRIRNELMQSLNQDSNSNFKDT-----LLKEREAEVRNLKQNLSELEQLN 665
Query: 302 QGHEKEMKGQVNKFQELQLQLEKAKVEL-----------IEKEKVLNKCRDELVRTTAQY 350
+ +K + ++L L E + +L +EK ++ + E A+
Sbjct: 666 ENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
Query: 351 DQASTKYTALEQKLKKLTEDLSCQRQ-NAESARCSLEQKIKEKEKEFQEELSRQQRSFQT 409
A + K +K E+LS R N + + E IK +K+ E++ +++ +
Sbjct: 726 CWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQ 784
Query: 410 LDQECIQMKARLTQELQQAKNMHNVLQAE---LDKLTSVKQQLENNLEEFKQKLCRAEQA 466
+D + + K L+ L++ K + ++ + ++KL +L+ L+++ Q L + E
Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
Query: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Q + K+ RS+ MK+ENN L+ E + RE A + + K L+ A E+
Sbjct: 845 RQTIEEKD----RSLGSMKEENNHLQEELE-RLREEQSRTAPVADPK-TLDSVTELASEV 898
Query: 527 KAKNTSQETMLRDLQ--EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
NT +E + +++ +KI + +N ++ L+ L++Q+ + + E
Sbjct: 899 SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ----SLQEQKKEMDEFRYQHEQMNATH 954
Query: 585 NDKLSKTEKESKALLSALE-LKKKEYEELKEEKTLFS--CWKSENEKLLTQMESEKENL- 640
+ ++E K+L +E +K + +EE ++ +T S +++ + L + SEK +L
Sbjct: 955 TQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 1014
Query: 641 QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV-EIRNLHNVLDSKSVEVE----- 694
+++ L +K ++++ NE+ +L + LS E+ L ++ K +E++
Sbjct: 1015 KAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHAR 1074
Query: 695 ------TQKLAYMELQQKAEFSDQK------HQKEIENMCLKTS-----QLTGQVEDLEH 737
TQ + Y++ Q +A +++ ++K EN LKT + E
Sbjct: 1075 ISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
Query: 738 KLQLLSNEIMDK-DRCYQDLHAE-YESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM-- 793
KLQ + ++ + + QD+ E ++L +++ KD + ++LLA Q +
Sbjct: 1135 KLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGN 1194
Query: 794 ------HHSFANIIGEQGSMPSE-------RSECRLEADQSPKNSAILQNRVDSLEFSLE 840
+ F ++ E+ + + + + SA LQ + L+ +
Sbjct: 1195 EAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVL 1254
Query: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL---QEDTSAHQN 897
NS LQ L+Q E+N K + Q +A+ I +L ++ +
Sbjct: 1255 VDSDNNSKLQVDYTGLIQ---SYEQNETKLKNFGQE-LAQVQHSIGQLCNTKDLLLGKLD 1310
Query: 898 VVAETLSAL-----------------------ENKEKELQLLNDKVETEQAEIQELKKSN 934
+++ LS+ E ++EL+ L ++ + A I+ L+++N
Sbjct: 1311 IISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENN 1370
Query: 935 HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
H L DS ++ T LE+KE S K+ E+ LKE + + + L+
Sbjct: 1371 HRLSDS------IAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424
Query: 995 QKSESFANYIDEREKSISELSDQYKQEKLILLQ--------RCEETGNAYEDLSQKYKAA 1046
+E+F N ++E E +++ +E++++L+ E+ Y +Y+A
Sbjct: 1425 SSNENFTNKVNENELLRQAVTN--LKERILILEMDIGKLKGENEKIVETYRGKETEYQAL 1482
Query: 1047 QEKNSKLECLLN----ECTSLCE--------------NRKNELEQLKEAFAKEHQEFLTK 1088
QE N K +L EC S+ E + EL QL A K QE
Sbjct: 1483 QETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNA-VKSMQE--KT 1539
Query: 1089 LAFAEERNQNLMLELETVQQ---ALRSE---MTDNQNNSKSEAGGLK-----------QE 1131
+ F +ER+Q +ML L+ Q AL++E + D + S E L+ +E
Sbjct: 1540 VVFQQERDQ-VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTRE 1598
Query: 1132 IMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFK 1191
+ ++ + K++K+V L ++ M+ +++ E ++ + +R++ +
Sbjct: 1599 ALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
Query: 1192 PQMDLE-VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250
+ E VK+ +L N Q+V K + E EK+K+ + N
Sbjct: 1659 LSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAE---------WKKNA 1709
Query: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
++++ + IS L++C +A NA L + + T +L+ +
Sbjct: 1710 ENLEGKVIS-LQECLDEA-----------------NAALDSASRLT----EQLD-----V 1742
Query: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370
+ E+ E + N+ R E M ++V K L + + N G + L+ ++ G F
Sbjct: 1743 KEEQIEELKRQNELRQE-------MLDDVQKKL--MSLANSSEGKVDKVLMRNLFIGHFH 1793
Query: 1371 EQPNEQHPV 1379
N++H V
Sbjct: 1794 TPKNQRHEV 1802
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 195 bits (495), Expect = 7e-49
Identities = 229/1010 (22%), Positives = 470/1010 (46%), Gaps = 105/1010 (10%)
Query: 1926 EVVQTEKLCLEKDNENKQKV---IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
E +Q ++ L+K E +QK + LE++ S +T E+N L+ +L ++ +++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
++ K QELE E LH EA ++E+ + Q L ++ ++ + L+E+L+ E
Sbjct: 912 RLAAKKQELE----EILH---EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 2043 DSQALSLTKC-------ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095
Q L L K +LE++I ++ + L KE + L+ R+S+ L
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-----------LTT 1013
Query: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS---- 2151
L E+ E A L+ + + + I +L VR++ +EK + + EKLK R+ E D+
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQEL-EKLK-RKLEGDASDFH 1068
Query: 2152 -----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
L+ ++ L+ +L EE + + ++ A+ +I E+ + + DL
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQL 2265
+ R+ + KQ K+ EL+ L + + L+ Q E++ K E + V +L+ L
Sbjct: 1129 SERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--VTVLKKAL 1183
Query: 2266 KELNEAVAALCGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCV 2320
E + A + Q+ +A E+ L +E+ + + +++K + LE AD +L V
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEE-LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
L Q K+ H K ++E +EL+ ++ E A E + +V L+ ++E +T L
Sbjct: 1243 LGQAKQEVEHK---KKKLEAQVQELQSKCSDGERARAELND---KVHKLQNEVESVTGML 1296
Query: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
E + + + +L+++LQ QE + E + L++ E+E+ ++++ M
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ-------LLQGLDEAK 2493
E Q L ++ L+ K K Q+ +S VE LE K + L Q +E
Sbjct: 1357 EAKQ----NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Y L+ + N L QE++D L+ + + +S L+ + + +QL+++ + ++ ++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
+ E + + ++K SL LE + LE + EL + +KM E +
Sbjct: 1473 R----------AEAEAREKETKALSLARALE------EALEAKEELERTNKMLKAEMEDL 1516
Query: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
+++K+ ++ + +HE+ + L+ ++ K +L+ L +E+++++D L +
Sbjct: 1517 VSSKD-DVGKNVHELEKSKRALETQMEEMKT----QLEELEDELQATEDAKLRLEVNMQA 1571
Query: 2674 LK----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
LK + L + EK +++ ++ EY+ L E E+K +AL K+ E +++
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL-EDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
+ S + ++ L++ ++ L+ +E+ T +N K L+ +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVMDTKVDELTTEIKE--- 2845
+ Q + ++ KQ + EKE L +EL S L Q ++ ++ +L E++E
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 2846 ----LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
+ + + + T++A++ ++ + + +K E A++ LE Q L S+
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Score = 194 bits (492), Expect = 1e-48
Identities = 265/1267 (20%), Positives = 543/1267 (42%), Gaps = 192/1267 (15%)
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
T P V E + L+K +E+ + E++ELEQ S +E + L++
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQE 894
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
Q +E E + + EM +LAA+K++ E++ E+E ARL+ +
Sbjct: 895 QLQAETELYAE-----AEEMRVRLAAKKQELEEILHEME-ARLE--------------EE 934
Query: 1661 EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE 1720
ED R + ++ ++ D+ + +++ L +EK+T +K E
Sbjct: 935 ED----RGQQLQAERKKMAQ-----QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL-E 984
Query: 1721 CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETS 1780
D N + E K E IS+L+ L +E
Sbjct: 985 DEILVMDDQNNKLSKERKL--LEERISDLT---------------------TNLAEEEEK 1021
Query: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENS 1840
+NL L K ES+++E+ EV+L + ++ ELEK+ +L+ + S
Sbjct: 1022 AKNLTKL------KNKHESMISEL----------EVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 1841 DLSEKLEYFSCDHQEL-LQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLD 1899
D E++ EL +Q + E L + L D+ +++ +N K + D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NNALKKIRELEGHISD 1122
Query: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSE 1959
++ +L R+ + E + L +LE ++TE +Q++ E+E++V+
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK- 1181
Query: 1960 RNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTL 2019
+ ++T + + ++M++K + +E L + A+A + + + L+
Sbjct: 1182 ---------ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 2020 SSDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
++D++ L+ K ++ K + LE Q L + E A+LN + L E ES+
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
L+E++ + + ++K + + LSS ++ +L ++ + +++
Sbjct: 1293 TGMLNEAEGKAIKLAKDVAS-----------LSSQLQDTQEL----------LQEETRQK 1331
Query: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
L+++ KL++ E E +SL+D+++ Q E + + + +SK +++ + +E +
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
K F+ E ENLT+Q +EK +L+K + ++++E
Sbjct: 1392 EGKKRFQ-------KEIENLTQQYEEKAAAYDKLEK--------------TKNRLQQELD 1430
Query: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
V L NQ + ++ ++ ++ D + EE + + R R EA+ +
Sbjct: 1431 DLVVDLDNQRQLVSN-----------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEG 2375
+ KE++ L + E LE + E+ RTN+ A E E+ + + +
Sbjct: 1480 E--------KETK-ALSLARALEEALEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHE 1529
Query: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI----INSSFENILQEKEQEKVQ 2431
+ +S R LE + ++++ E L +ELQ ++ LE+ + FE LQ ++++ +
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
+ + LQ QL E + + A ++ L ++ LEL+ ++G +E
Sbjct: 1590 KRRQ-------LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE---- 2547
A LQ+ + +E+ED + +DE + K + + L + L Q++ +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDAR---ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
+ K+ +LE L EL L +NA LQD L++ LE ELE + + +
Sbjct: 1700 ERARKQADLEKEELAEELASS---LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 2608 VEKVNKMTAKETELQREM---HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS-KDQ 2663
++V K T + +L E+ AQK +++L + L +L + +KS K
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
+ L + ++L ++QVE+E + ++ + L + +KK + +LL + ++
Sbjct: 1816 IAALEAKIAQL--------EEQVEQEAREKQAATK---SLKQKDKKLKEILLQVEDERKM 1864
Query: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ 2783
Q Y+E+ + K +++ + + +N + + + L+E ++ + VN
Sbjct: 1865 AEQ-YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 2784 LKKENER 2790
LK + R
Sbjct: 1924 LKSKLRR 1930
Score = 162 bits (410), Expect = 5e-39
Identities = 239/1154 (20%), Positives = 487/1154 (42%), Gaps = 124/1154 (10%)
Query: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
LQK +E + + + KE +Q+ QL + LQ+Q Q T L E + +
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-------AETELYAEAEEMRVRL 913
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
+ ++ ++I HE++ + + + QL + +K K+ Q++ + +LE + A Q
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQK-- 968
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVKALQAKK 192
+ L KI K ED + ++ NK +ERK LE + L
Sbjct: 969 LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
A + + +H+ S+ S + + S + ++R +++
Sbjct: 1016 AEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
++ + K + ++ LD AQ KI ELE GH +++ +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDL 1127
Query: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
+ + + + EK K +L E+ + L ++ + +TA + K EQ++ L + L
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK---REQEVTVLKKALD 1184
Query: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
+ ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENADLAGEL 1240
Query: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
VL ++ K++LE ++E + K E+A K ++L+ +E + N +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
+ + A++V L ++L++ +Q +E + + T LR L+E+ N ++ L
Sbjct: 1301 GKAIKLAKDVASLSSQLQD-------TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 553 LE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
E L+ ++ L Q S+ L+ +E L + + +KE + L E K
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKSHEY--- 661
Y++L++ K + E + L+ ++++++ NL+ K + L ++ S +Y
Sbjct: 1414 AYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 662 NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQ----QKAEFSDQKHQK 716
+R ++E ++ + R L L++K T K+ E++ K + H+
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 717 EIENMCLKT--SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL + +
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNE 1588
Query: 775 VTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
QR L ++ + A + + + + L+AD + ++ R +
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------IKGREE 1642
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV--------AET 881
+++ + Q QM D Q++ E+ + EI +EN KA+ + + AE
Sbjct: 1643 AIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+++ + L+++ A + +A +LS + E + L ++ + E++E + + + D +
Sbjct: 1702 ARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
++ +E LS E S N+ ++L ++N KE+ + L++ + + K F
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSK---FK 1813
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
+ I E I++L +Q +QE E A + L QK K L E
Sbjct: 1814 STIAALEAKIAQLEEQVEQE-------AREKQAATKSLKQKDKK-----------LKEIL 1855
Query: 1062 SLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118
E+ + EQ KE K + ++ +L AEE +Q + +Q+ L E T++
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-DEATESN 1914
Query: 1119 NNSKSEAGGLKQEI 1132
E LK ++
Sbjct: 1915 EAMGREVNALKSKL 1928
Score = 159 bits (402), Expect = 4e-38
Identities = 238/1174 (20%), Positives = 498/1174 (42%), Gaps = 145/1174 (12%)
Query: 324 KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
K +++ +E+ + DEL +T + +A + LEQK +LTE+ +N +
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-----KNLLQEQL 896
Query: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
E ++ + +E + L+ ++ Q L++ +M+ARL +E + + LQAE K+
Sbjct: 897 QAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQ----LQAERKKMA 949
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
LE LEE E A Q Q+++ +++++ E ++ + + ++E
Sbjct: 950 QQMLDLEEQLEE-------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS-LTLEKLKLAVAD 562
LE + ++ L + + A+ + E+M+ +L+ ++ ++E S LEKLK
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK---RK 1059
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCW 622
LE + + + I +L +L+K E+E +A L+ L+ +E+ ++
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQKNNAL--- 1110
Query: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
+ L+ I+ L+ L +++ ++ ++ R L + E L E L
Sbjct: 1111 ------------KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1155
Query: 683 HNVLDSKSVEVETQKLAYME---LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+ LDS + + E + E L++ + + H+ +++ M K +Q VE+L +L
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEELTEQL 1212
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN 799
+ + D+ Q L E L L+ +L +Q H
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELR---------------VLGQAKQEVEH----- 1252
Query: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
++ + ++ E + + + A L ++V L+ +ES M ++ + + +L +
Sbjct: 1253 ---KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 860 KGEIEENLMKAEQMHQSFVAE---TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
+ L +++ Q + S ++ +L+E+ ++ Q+ + E + A +N E+ + L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
N ++ + ++Q+ + LE+ K Q E L+ + +E ++ ++ L QE
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 977 GTLKEINASLNQEKMNLIQKSESF-----------ANYIDEREKSISELSDQYKQEKLIL 1025
L + Q NL +K F + Y DER+++ +E ++ + + L L
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSL 1488
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+ EE A E+L + K + +++E L++ + +N +ELE+ K A + +E
Sbjct: 1489 ARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEM 1544
Query: 1086 LTKLAFAEER---NQNLMLELETVQQALRSEM-TDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
T+L E+ ++ L LE QAL+ + D Q + +Q L E + +
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHE--CQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
++ E ++ L K K E ++LE + +++K RE Q K Q ++
Sbjct: 1605 LEDE-----RKQRALAAAAKKKLEGDLKDLELQ-ADSAIKGREEAIKQLR-KLQAQMKDF 1657
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-----RGDLETSNLQDMQ 1254
+ L+ A ++ A + E K + E + LQ +L + DLE L +
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 1255 SQEISG---LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
+ +SG L+D + E + EL Q + + ++ + +L
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------ 1771
Query: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
EL TE + ++ + R+ E K L L++ G + + I E
Sbjct: 1772 ----ELATERSTAQKN--ESARQQLERQNKELRSK--LHEMEGAVKSKFKSTIAALE--- 1820
Query: 1372 QPNEQHPVSLAPLDESNSYE--HLTLSDKEVQMHFAELQEKFLSLQSEHKILH---DQHC 1426
+A L+E E + K ++ +L+E L ++ E K+ +Q
Sbjct: 1821 -------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
+ ++++ +L+ ++ + E+ ++ N R Q +L
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 155 bits (392), Expect = 6e-37
Identities = 221/1141 (19%), Positives = 482/1141 (42%), Gaps = 163/1141 (14%)
Query: 110 QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTP--------LTPSQYYS- 160
Q+ + E+E++ + EL+++++ Q A+ L T ++ Y+
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 161 --------GSKYEDLKE---KYNKEVEERKRLEAEVKALQAKKASQTLP-QATMNHRDIA 208
+K ++L+E + +EE + +++A + K A Q L + + + A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 209 RHQASSSVFSWQQEKTPSHLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDAN 267
R + Q EK + I D + S E+++ R + D
Sbjct: 966 RQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS------DLT 1012
Query: 268 SSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK----------EMKGQVNKFQE 317
++ + L +LK +++ + I+ELE+RL+ EK +++G + F E
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 318 ----LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
LQ Q+ + K++L +KE+ L L AQ + A K LE + L EDL
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 374 QR--------------QNAESARCSLE---------QKIKEKEKE----FQEELSRQQRS 406
+R + E+ + LE Q+++ K ++ ++ L + RS
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
+ QE Q A+ +EL + +A LDK KQ LE + +L QA
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVLGQA 1246
Query: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Q + K+ +L ++E++ + + + + +V L+ E++++ LN+++ A ++
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLA--VADLEKQRDCSQDLLKKR------- 577
S + L+D QE + ++ T +KL ++ + LE++R+ QD L +
Sbjct: 1307 AKDVASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 578 EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK 637
E HI LN +LS ++K+ + S +E ++ + ++E + E ++E K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 638 ENLQSKINHLETCLKTQQIKSHEYNERVRTLEM---DRENLSVEIRNLHNVLDSKSVEVE 694
LQ +++ L L Q+ ++ R + + +N+S + + + ++++ E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 695 TQKLAY-------MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
T+ L+ +E +++ E +++ + E+E++ + V +LE + L ++
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 748 DKDRCYQDLHAEYESLRDLLKSKDASL-VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
+ ++L E ++ D + ++ +R L A D+Q ++
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE---------EKRRQ 1593
Query: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN 866
+ + E E + K A+ LE L+ DL+ Q + ++ + E +
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-------DLELQADSAIKGREEAIKQ 1646
Query: 867 LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
L K + + F E ED A ++ + T E K K L +A+
Sbjct: 1647 LRKLQAQMKDFQREL--------EDARASRDEIFATAKENEKKAKSL----------EAD 1688
Query: 927 IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
+ +L++ E + K+ L E L+ +E++S +S +E + + ++ L
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELA---EELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
+E+ N+ E+ ++ + + + +LS++ E+ ++ +A + L ++ K
Sbjct: 1746 EEEQGNM----EAMSDRVRKATQQAEQLSNELATER----STAQKNESARQQLERQNKEL 1797
Query: 1047 QEKNSKLE----CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLE 1102
+ K ++E + E + +LE+ E A+E Q L +++ + ++L+
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 1103 LETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE-------QNKMQKEVNDLLQENEQ 1155
+E ++ + + + + LK+++ +EE + K+Q+E+++ + NE
Sbjct: 1858 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 1156 L 1156
+
Sbjct: 1917 M 1917
Score = 155 bits (391), Expect = 8e-37
Identities = 223/1140 (19%), Positives = 483/1140 (42%), Gaps = 124/1140 (10%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNLKRENQ 70
TR +++Q E +L K K+ +Q+ + +L LE + L ++K ++ + T L E +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
+ + ++ ++I HE++ + + + QL + +K K+ Q++ + +LE +
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEA 964
Query: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVK 186
A Q + L KI K ED + ++ NK +ERK LE +
Sbjct: 965 ARQK--LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Query: 187 ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYF 246
L A + + +H+ S+ S + + S + ++R
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 247 SGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK 306
+++ ++ + K + ++ LD AQ KI ELE GH
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHIS 1121
Query: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKK 366
+++ ++ + + + EK K +L E+ + L ++ + +TA + K EQ++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQEVTV 1178
Query: 367 LTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
L + L + ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENA 1234
Query: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
VL ++ K++LE ++E + K E+A K ++L+ +E +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
N + + + A++V L ++L++ ++ L + E + N S T LR L+E+ N
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-----ETRQKLNVS--TKLRQLEEERNS 1347
Query: 547 QENSLTLE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSA 601
++ L E L+ ++ L Q S+ L+ +E L + + +KE + L
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 602 LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKS 658
E K Y++L++ K + E + L+ ++++++ NL+ K + L ++ S
Sbjct: 1408 YEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 659 HEY---NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQQ----KAEFS 710
+Y +R ++E ++ + R L L++K T K+ E++ K +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 711 DQKHQKEIENMCLKTS--QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
H+ E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQA 1582
Query: 769 SKDASLVTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
+ + QR L ++ + A + + + + L+AD +
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------ 1636
Query: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV----- 878
++ R ++++ + Q QM D Q++ E+ + EI +EN KA+ + +
Sbjct: 1637 IKGREEAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 879 ---AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
AE +++ + L+++ A + +A +LS + E + L ++ + E++E + +
Sbjct: 1696 LAAAERARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 936 LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN------------------- 976
+ D +++ +E LS E S N+ ++L ++N
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1813
Query: 977 GTLKEINASLNQEKMNLIQKS---ESFANYIDEREKSISEL----------SDQYKQEKL 1023
T+ + A + Q + + Q++ ++ + +++K + E+ ++QYK++
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ 1083
R ++ E+ ++ + KL+ L+E T E E+ LK + ++
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 140 bits (352), Expect = 3e-32
Identities = 231/1141 (20%), Positives = 470/1141 (41%), Gaps = 147/1141 (12%)
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
++E ++ D+L KT++ + + L+ ++++ +L EEK L +L + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695
+ L +K LE L + + E +R + L+ +R+ ++ ++ +L L+ + E
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAAR 966
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
QKL ++ +A+ +K + EI M + ++L+ + + LE ++ L+ + +++ ++
Sbjct: 967 QKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-----PAMHHSFANI---IGEQGSM 807
L ++ + L E ++ L ++ H A++ I E
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 808 PSERSE------CRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQ---- 852
+++ E RL+ + + KN+A+ L+ + L+ L+S++ + +KQ
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS----KLQEDTSAHQNVVAET----LS 904
EEL +K E+E+ L + Q A+ Q ++ L E+T +H+ V E
Sbjct: 1145 GEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISL 964
A+E ++L+ Q L+K N L L+ L + + +KK++ +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---- 1259
Query: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE-------KSISELSDQ 1017
+++EL + + A LN + L + ES ++E E K ++ LS Q
Sbjct: 1260 ---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ + +L + + N +S K + +E+ + L+ L+E +N + + L
Sbjct: 1317 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1078 FA---KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
+ K+ Q+F + + EE + E+E + Q + K++ L+QE+
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELDD 1431
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVM-KTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
L + + ++ V++L ++ + +++ + K+ E R + RE E +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 1194 MD--LEVKEISLDSYNAQL-VQLEAMLRNKE---LKLQESEKEKECLQHELQTIRGDLET 1247
++ LE KE L+ N L ++E ++ +K+ + E EK K L+ +++ ++ LE
Sbjct: 1492 LEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC 1307
++Q+ E + L+ ++ + + G E D + + Q
Sbjct: 1551 LE-DELQATEDAKLR---LEVNMQALKGQFERDLQARDEQNEEKRRQ------------- 1593
Query: 1308 EILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG 1367
LQ + +E TEL D R + A + G L ++++ D + I G
Sbjct: 1594 --LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSA----------IKGR 1640
Query: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427
E E + + D E S E+ E ++K SL+++
Sbjct: 1641 E--EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD---------- 1688
Query: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS-SCVPDSSS 1486
+ +LQ E+L + R Q DL KE L E L SLS + + D
Sbjct: 1689 ----LMQLQ--------EDLAAAERARK-QADLEKE---ELAEELASSLSGRNALQDEKR 1732
Query: 1487 LSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546
+ L E+ G+M +S+ + L E T + T
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ--------AEQLSNELATERSTAQKNE 1784
Query: 1547 KGVEELESLCEVYRQSLEKLE----EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602
++LE + R L ++E K +S +I +LE+ + E +E K
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQ--------TEQLSLELEVARLQLQGLDLSSRS 1654
++++ ++ L V E E K+A + K+ +QL +LE A + Q ++ + R
Sbjct: 1845 KQKDKKLKEILLQV--EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 1655 L 1655
L
Sbjct: 1903 L 1903
Score = 117 bits (293), Expect = 2e-25
Identities = 229/1150 (19%), Positives = 473/1150 (41%), Gaps = 122/1150 (10%)
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
++ L + T + + A+ + KE++ + N+ E EQ Q ++ N L E E
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 944 LQLLSET------LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL---I 994
+L +E L+ +K+E+ I+ + +EE L+ + Q+ ++L +
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 995 QKSESFANYID----EREKSISELSDQ----------YKQEKLILLQRCEETGNAYEDLS 1040
++ E+ + E I +L D+ +E+ +L +R + +
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 1041 QKYKAAQEKNSKLECLLNECTSLC---ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
+K K + +K E +++E E + ELE+LK + +F ++A + +
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 1098 NLMLELETVQQALRSEMT------DNQNNSKSEAGGLKQEIMTLKEE-------QNKMQK 1144
L ++L ++ L++ + +NN+ + L+ I L+E+ +NK +K
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
+ DL +E ++ +KT+ E L+S + ++ + E+ K +D E +
Sbjct: 1140 QKRDLGEE----LEALKTELE-DTLDSTATQQELRAKR-EQEVTVLKKALDEETR----- 1188
Query: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264
S+ AQ+ ++ +L E ++ + + L + LE N + G
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 1265 EIDAEEKYISGP-HELSTSQNDNAHLQCSLQTTMNKL-NELEKICEIL---QAEKYELVT 1319
E++ ++K + EL + +D + L ++KL NE+E + +L + + +L
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 1320 ELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
++ S+ + EE + LN +++ L ++ L +L E++ +Q E+
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME----AKQNLER 1364
Query: 1377 HPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
H +S + S+S + L ++ L+E Q E + L Q+ + ++ +L+
Sbjct: 1365 H-ISTLNIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
+ L+ E L +L N Q LV ++ ++ L + SS + D +
Sbjct: 1420 KTKNRLQQELDDLVVDLDN-QRQLVSNLE--KKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1497 RALLEQTGDMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE---- 1551
A ++T +SL LE A+ A + + E+ ++ K+ +E+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
LE+ E + LE+LE+++++ K + ++ L ++L +Q NE+ ++
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ----NEEKRR 1592
Query: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC 1671
+L E E++L E+KQ + A+ +L+G DL L + + AI+GR E+
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAA----AAKKKLEG-DLKD---LELQADSAIKGREEAI 1644
Query: 1672 DISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNY 1731
++ ++ K ++ D A +D K E A + Q
Sbjct: 1645 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 1732 EPPGEDKTQGSSECISEL--SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + E EL S SG NAL Q++ L+ R+ + E
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNAL--------QDEKRRLEARIAQLEEE------- 1744
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL-EY 1848
+E+ +E++ + +++ + +L T+ + E +L+++N +L KL E
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLDVENELSR 1906
+ + E + LE ++ +RE ++ + + KE L VE+E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1907 IRSEKASIEH---EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
K E L+ LE + E ++ N N++K L+ EL T +
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRK----LQRELDEATESNEAM 1917
Query: 1964 RGELDTMSKK 1973
E++ + K
Sbjct: 1918 GREVNALKSK 1927
Score = 85.9 bits (211), Expect = 6e-16
Identities = 121/550 (22%), Positives = 225/550 (40%), Gaps = 72/550 (13%)
Query: 4 ALEEWKEGLPTRA---LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN--- 57
ALEE K+ Q+ +E DKL+K K + Q +LD L L Q+Q V N
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 58 --------------------------------EKTEGTNLKRENQRLMEICESLEKTKQK 85
++T+ +L R + +E E LE+T +
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 86 ISHELQ---VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
+ E++ + V +L K+ +E +E+K ELE QA + A + L
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 143 NTPQK-IFTTPLTPSQYYSGSKYEDLKEK---YNKEVEE-----------RKRLEAEVK- 186
K F L + K L+ + Y E+E+ +K+LE ++K
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 187 -ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
LQA A + +A R + QA F Q + +S + ++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKL---QAQMKDF---QRELEDARASRDEIFATAKENEKKA 1682
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S E ++ + L +R + + L + L+++ LE R+ E
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1742
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK-- 363
+E++ + + + ++ KA + E++ N+ E R+TAQ ++++ + + K
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQA---EQLSNELATE--RSTAQKNESARQQLERQNKEL 1797
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
KL E + +S +LE KI + E++ ++E +Q + ++L Q+ ++K L Q
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE 483
++ + M + + +K + +QL+ LEE +++ R + Q + +E S E
Sbjct: 1858 -VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 484 MKKENNLLKS 493
M +E N LKS
Sbjct: 1917 MGREVNALKS 1926
Score = 73.2 bits (178), Expect = 4e-12
Identities = 86/423 (20%), Positives = 196/423 (46%), Gaps = 61/423 (14%)
Query: 2516 KLEKKDEEISRLKNQIQD----QEQLVSKLSQVEGEH-QLWKEQNL-------------E 2557
++ +++EE+ ++++Q Q++ ++L ++E +H QL +E+NL E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
+ V L K Q L+ ++ LE + + L+ E + + E++ + A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 2618 ETELQREMHEMAQKTAELQEE---LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
+LQ E K +L++E + + N+L+ E +LL E I L E E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE------EE 1019
Query: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
+K+ K+ + + K I+E ++RL + EK Q L ++ E + + E++
Sbjct: 1020 EKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIAD 1073
Query: 2735 KEECLSSQKLEI----DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
+ ++ K+++ + L+++ L++ + L+++++ + +++ L+++ +
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDLDS 1129
Query: 2791 AQGKMKLLIKSCKQLEEEKEILQKEL--------SQLQAAQEKQKTGTVMDTKVDELT-- 2840
+ K + L EE E L+ EL +Q + ++++ TV+ +DE T
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 2841 --TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ-----QS 2893
+++E+++ + +E E L+++ + L+K K+ LE + A L + Q+
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKR---AKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 2894 KQD 2896
KQ+
Sbjct: 1247 KQE 1249
Score = 35.8 bits (81), Expect = 0.68
Identities = 24/114 (21%), Positives = 54/114 (47%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
KI +LE Q+++ +EKQ L + L++ +VE+E+ K + ++ +
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
L++ ++ E Q + + +L+ + E + +E+ KS+L R + +
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 195 bits (495), Expect = 7e-49
Identities = 229/1010 (22%), Positives = 470/1010 (46%), Gaps = 105/1010 (10%)
Query: 1926 EVVQTEKLCLEKDNENKQKV---IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
E +Q ++ L+K E +QK + LE++ S +T E+N L+ +L ++ +++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
++ K QELE E LH EA ++E+ + Q L ++ ++ + L+E+L+ E
Sbjct: 919 RLAAKKQELE----EILH---EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 2043 DSQALSLTKC-------ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095
Q L L K +LE++I ++ + L KE + L+ R+S+ L
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-----------LTT 1020
Query: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS---- 2151
L E+ E A L+ + + + I +L VR++ +EK + + EKLK R+ E D+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQEL-EKLK-RKLEGDASDFH 1075
Query: 2152 -----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
L+ ++ L+ +L EE + + ++ A+ +I E+ + + DL
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQL 2265
+ R+ + KQ K+ EL+ L + + L+ Q E++ K E + V +L+ L
Sbjct: 1136 SERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--VTVLKKAL 1190
Query: 2266 KELNEAVAALCGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCV 2320
E + A + Q+ +A E+ L +E+ + + +++K + LE AD +L V
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEE-LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
L Q K+ H K ++E +EL+ ++ E A E + +V L+ ++E +T L
Sbjct: 1250 LGQAKQEVEHK---KKKLEAQVQELQSKCSDGERARAELND---KVHKLQNEVESVTGML 1303
Query: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
E + + + +L+++LQ QE + E + L++ E+E+ ++++ M
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ-------LLQGLDEAK 2493
E Q L ++ L+ K K Q+ +S VE LE K + L Q +E
Sbjct: 1364 EAKQ----NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Y L+ + N L QE++D L+ + + +S L+ + + +QL+++ + ++ ++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
+ E + + ++K SL LE + LE + EL + +KM E +
Sbjct: 1480 R----------AEAEAREKETKALSLARALE------EALEAKEELERTNKMLKAEMEDL 1523
Query: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
+++K+ ++ + +HE+ + L+ ++ K +L+ L +E+++++D L +
Sbjct: 1524 VSSKD-DVGKNVHELEKSKRALETQMEEMKT----QLEELEDELQATEDAKLRLEVNMQA 1578
Query: 2674 LK----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
LK + L + EK +++ ++ EY+ L E E+K +AL K+ E +++
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL-EDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
+ S + ++ L++ ++ L+ +E+ T +N K L+ +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVMDTKVDELTTEIKE--- 2845
+ Q + ++ KQ + EKE L +EL S L Q ++ ++ +L E++E
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 2846 ----LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
+ + + + T++A++ ++ + + +K E A++ LE Q L S+
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Score = 194 bits (492), Expect = 1e-48
Identities = 265/1267 (20%), Positives = 543/1267 (42%), Gaps = 192/1267 (15%)
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
T P V E + L+K +E+ + E++ELEQ S +E + L++
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQE 901
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
Q +E E + + EM +LAA+K++ E++ E+E ARL+ +
Sbjct: 902 QLQAETELYAE-----AEEMRVRLAAKKQELEEILHEME-ARLE--------------EE 941
Query: 1661 EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE 1720
ED R + ++ ++ D+ + +++ L +EK+T +K E
Sbjct: 942 ED----RGQQLQAERKKMAQ-----QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL-E 991
Query: 1721 CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETS 1780
D N + E K E IS+L+ L +E
Sbjct: 992 DEILVMDDQNNKLSKERKL--LEERISDLT---------------------TNLAEEEEK 1028
Query: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENS 1840
+NL L K ES+++E+ EV+L + ++ ELEK+ +L+ + S
Sbjct: 1029 AKNLTKL------KNKHESMISEL----------EVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 1841 DLSEKLEYFSCDHQEL-LQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLD 1899
D E++ EL +Q + E L + L D+ +++ +N K + D
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NNALKKIRELEGHISD 1129
Query: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSE 1959
++ +L R+ + E + L +LE ++TE +Q++ E+E++V+
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK- 1188
Query: 1960 RNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTL 2019
+ ++T + + ++M++K + +E L + A+A + + + L+
Sbjct: 1189 ---------ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 2020 SSDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
++D++ L+ K ++ K + LE Q L + E A+LN + L E ES+
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
L+E++ + + ++K + + LSS ++ +L ++ + +++
Sbjct: 1300 TGMLNEAEGKAIKLAKDVAS-----------LSSQLQDTQEL----------LQEETRQK 1338
Query: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
L+++ KL++ E E +SL+D+++ Q E + + + +SK +++ + +E +
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
K F+ E ENLT+Q +EK +L+K + ++++E
Sbjct: 1399 EGKKRFQ-------KEIENLTQQYEEKAAAYDKLEK--------------TKNRLQQELD 1437
Query: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
V L NQ + ++ ++ ++ D + EE + + R R EA+ +
Sbjct: 1438 DLVVDLDNQRQLVSN-----------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEG 2375
+ KE++ L + E LE + E+ RTN+ A E E+ + + +
Sbjct: 1487 E--------KETK-ALSLARALEEALEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHE 1536
Query: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI----INSSFENILQEKEQEKVQ 2431
+ +S R LE + ++++ E L +ELQ ++ LE+ + FE LQ ++++ +
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
+ + LQ QL E + + A ++ L ++ LEL+ ++G +E
Sbjct: 1597 KRRQ-------LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE---- 2547
A LQ+ + +E+ED + +DE + K + + L + L Q++ +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDAR---ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
+ K+ +LE L EL L +NA LQD L++ LE ELE + + +
Sbjct: 1707 ERARKQADLEKEELAEELASS---LSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 2608 VEKVNKMTAKETELQREM---HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS-KDQ 2663
++V K T + +L E+ AQK +++L + L +L + +KS K
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
+ L + ++L ++QVE+E + ++ + L + +KK + +LL + ++
Sbjct: 1823 IAALEAKIAQL--------EEQVEQEAREKQAATK---SLKQKDKKLKEILLQVEDERKM 1871
Query: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ 2783
Q Y+E+ + K +++ + + +N + + + L+E ++ + VN
Sbjct: 1872 AEQ-YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 2784 LKKENER 2790
LK + R
Sbjct: 1931 LKSKLRR 1937
Score = 162 bits (410), Expect = 5e-39
Identities = 239/1154 (20%), Positives = 487/1154 (42%), Gaps = 124/1154 (10%)
Query: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
LQK +E + + + KE +Q+ QL + LQ+Q Q T L E + +
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-------AETELYAEAEEMRVRL 920
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
+ ++ ++I HE++ + + + QL + +K K+ Q++ + +LE + A Q
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQK-- 975
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVKALQAKK 192
+ L KI K ED + ++ NK +ERK LE + L
Sbjct: 976 LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
A + + +H+ S+ S + + S + ++R +++
Sbjct: 1023 AEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
++ + K + ++ LD AQ KI ELE GH +++ +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDL 1134
Query: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
+ + + + EK K +L E+ + L ++ + +TA + K EQ++ L + L
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK---REQEVTVLKKALD 1191
Query: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
+ ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENADLAGEL 1247
Query: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
VL ++ K++LE ++E + K E+A K ++L+ +E + N +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
+ + A++V L ++L++ +Q +E + + T LR L+E+ N ++ L
Sbjct: 1308 GKAIKLAKDVASLSSQLQD-------TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 553 LE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
E L+ ++ L Q S+ L+ +E L + + +KE + L E K
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKSHEY--- 661
Y++L++ K + E + L+ ++++++ NL+ K + L ++ S +Y
Sbjct: 1421 AYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 662 NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQ----QKAEFSDQKHQK 716
+R ++E ++ + R L L++K T K+ E++ K + H+
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 717 EIENMCLKT--SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL + +
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNE 1595
Query: 775 VTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
QR L ++ + A + + + + L+AD + ++ R +
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------IKGREE 1649
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV--------AET 881
+++ + Q QM D Q++ E+ + EI +EN KA+ + + AE
Sbjct: 1650 AIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+++ + L+++ A + +A +LS + E + L ++ + E++E + + + D +
Sbjct: 1709 ARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
++ +E LS E S N+ ++L ++N KE+ + L++ + + K F
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSK---FK 1820
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
+ I E I++L +Q +QE E A + L QK K L E
Sbjct: 1821 STIAALEAKIAQLEEQVEQE-------AREKQAATKSLKQKDKK-----------LKEIL 1862
Query: 1062 SLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118
E+ + EQ KE K + ++ +L AEE +Q + +Q+ L E T++
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-DEATESN 1921
Query: 1119 NNSKSEAGGLKQEI 1132
E LK ++
Sbjct: 1922 EAMGREVNALKSKL 1935
Score = 159 bits (402), Expect = 4e-38
Identities = 238/1174 (20%), Positives = 498/1174 (42%), Gaps = 145/1174 (12%)
Query: 324 KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
K +++ +E+ + DEL +T + +A + LEQK +LTE+ +N +
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-----KNLLQEQL 903
Query: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
E ++ + +E + L+ ++ Q L++ +M+ARL +E + + LQAE K+
Sbjct: 904 QAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQ----LQAERKKMA 956
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
LE LEE E A Q Q+++ +++++ E ++ + + ++E
Sbjct: 957 QQMLDLEEQLEE-------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS-LTLEKLKLAVAD 562
LE + ++ L + + A+ + E+M+ +L+ ++ ++E S LEKLK
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK---RK 1066
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCW 622
LE + + + I +L +L+K E+E +A L+ L+ +E+ ++
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQKNNAL--- 1117
Query: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
+ L+ I+ L+ L +++ ++ ++ R L + E L E L
Sbjct: 1118 ------------KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1162
Query: 683 HNVLDSKSVEVETQKLAYME---LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+ LDS + + E + E L++ + + H+ +++ M K +Q VE+L +L
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEELTEQL 1219
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN 799
+ + D+ Q L E L L+ +L +Q H
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELR---------------VLGQAKQEVEH----- 1259
Query: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
++ + ++ E + + + A L ++V L+ +ES M ++ + + +L +
Sbjct: 1260 ---KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 860 KGEIEENLMKAEQMHQSFVAE---TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
+ L +++ Q + S ++ +L+E+ ++ Q+ + E + A +N E+ + L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
N ++ + ++Q+ + LE+ K Q E L+ + +E ++ ++ L QE
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 977 GTLKEINASLNQEKMNLIQKSESF-----------ANYIDEREKSISELSDQYKQEKLIL 1025
L + Q NL +K F + Y DER+++ +E ++ + + L L
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSL 1495
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+ EE A E+L + K + +++E L++ + +N +ELE+ K A + +E
Sbjct: 1496 ARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEM 1551
Query: 1086 LTKLAFAEER---NQNLMLELETVQQALRSEM-TDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
T+L E+ ++ L LE QAL+ + D Q + +Q L E + +
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHE--CQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
++ E ++ L K K E ++LE + +++K RE Q K Q ++
Sbjct: 1612 LEDE-----RKQRALAAAAKKKLEGDLKDLELQ-ADSAIKGREEAIKQLR-KLQAQMKDF 1664
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-----RGDLETSNLQDMQ 1254
+ L+ A ++ A + E K + E + LQ +L + DLE L +
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 1255 SQEISG---LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
+ +SG L+D + E + EL Q + + ++ + +L
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------ 1778
Query: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
EL TE + ++ + R+ E K L L++ G + + I E
Sbjct: 1779 ----ELATERSTAQKN--ESARQQLERQNKELRSK--LHEMEGAVKSKFKSTIAALE--- 1827
Query: 1372 QPNEQHPVSLAPLDESNSYE--HLTLSDKEVQMHFAELQEKFLSLQSEHKILH---DQHC 1426
+A L+E E + K ++ +L+E L ++ E K+ +Q
Sbjct: 1828 -------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
+ ++++ +L+ ++ + E+ ++ N R Q +L
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 155 bits (392), Expect = 6e-37
Identities = 221/1141 (19%), Positives = 482/1141 (42%), Gaps = 163/1141 (14%)
Query: 110 QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTP--------LTPSQYYS- 160
Q+ + E+E++ + EL+++++ Q A+ L T ++ Y+
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 161 --------GSKYEDLKE---KYNKEVEERKRLEAEVKALQAKKASQTLP-QATMNHRDIA 208
+K ++L+E + +EE + +++A + K A Q L + + + A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 209 RHQASSSVFSWQQEKTPSHLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDAN 267
R + Q EK + I D + S E+++ R + D
Sbjct: 973 RQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS------DLT 1019
Query: 268 SSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK----------EMKGQVNKFQE 317
++ + L +LK +++ + I+ELE+RL+ EK +++G + F E
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 318 ----LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
LQ Q+ + K++L +KE+ L L AQ + A K LE + L EDL
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 374 QR--------------QNAESARCSLE---------QKIKEKEKE----FQEELSRQQRS 406
+R + E+ + LE Q+++ K ++ ++ L + RS
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
+ QE Q A+ +EL + +A LDK KQ LE + +L QA
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVLGQA 1253
Query: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Q + K+ +L ++E++ + + + + +V L+ E++++ LN+++ A ++
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLA--VADLEKQRDCSQDLLKKR------- 577
S + L+D QE + ++ T +KL ++ + LE++R+ QD L +
Sbjct: 1314 AKDVASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 578 EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEK 637
E HI LN +LS ++K+ + S +E ++ + ++E + E ++E K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 638 ENLQSKINHLETCLKTQQIKSHEYNERVRTLEM---DRENLSVEIRNLHNVLDSKSVEVE 694
LQ +++ L L Q+ ++ R + + +N+S + + + ++++ E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 695 TQKLAY-------MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
T+ L+ +E +++ E +++ + E+E++ + V +LE + L ++
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 748 DKDRCYQDLHAEYESLRDLLKSKDASL-VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
+ ++L E ++ D + ++ +R L A D+Q ++
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE---------EKRRQ 1600
Query: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN 866
+ + E E + K A+ LE L+ DL+ Q + ++ + E +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-------DLELQADSAIKGREEAIKQ 1653
Query: 867 LMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
L K + + F E ED A ++ + T E K K L +A+
Sbjct: 1654 LRKLQAQMKDFQREL--------EDARASRDEIFATAKENEKKAKSL----------EAD 1695
Query: 927 IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
+ +L++ E + K+ L E L+ +E++S +S +E + + ++ L
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELA---EELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
+E+ N+ E+ ++ + + + +LS++ E+ ++ +A + L ++ K
Sbjct: 1753 EEEQGNM----EAMSDRVRKATQQAEQLSNELATER----STAQKNESARQQLERQNKEL 1804
Query: 1047 QEKNSKLE----CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLE 1102
+ K ++E + E + +LE+ E A+E Q L +++ + ++L+
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 1103 LETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE-------QNKMQKEVNDLLQENEQ 1155
+E ++ + + + + LK+++ +EE + K+Q+E+++ + NE
Sbjct: 1865 VED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 1156 L 1156
+
Sbjct: 1924 M 1924
Score = 155 bits (391), Expect = 8e-37
Identities = 223/1140 (19%), Positives = 483/1140 (42%), Gaps = 124/1140 (10%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNLKRENQ 70
TR +++Q E +L K K+ +Q+ + +L LE + L ++K ++ + T L E +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
+ + ++ ++I HE++ + + + QL + +K K+ Q++ + +LE +
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEA 971
Query: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVK 186
A Q + L KI K ED + ++ NK +ERK LE +
Sbjct: 972 ARQK--LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Query: 187 ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYF 246
L A + + +H+ S+ S + + S + ++R
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 247 SGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK 306
+++ ++ + K + ++ LD AQ KI ELE GH
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHIS 1128
Query: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKK 366
+++ ++ + + + EK K +L E+ + L ++ + +TA + K EQ++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR---EQEVTV 1185
Query: 367 LTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
L + L + ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENA 1241
Query: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
VL ++ K++LE ++E + K E+A K ++L+ +E +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
N + + + A++V L ++L++ ++ L + E + N S T LR L+E+ N
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-----ETRQKLNVS--TKLRQLEEERNS 1354
Query: 547 QENSLTLE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSA 601
++ L E L+ ++ L Q S+ L+ +E L + + +KE + L
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 602 LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKS 658
E K Y++L++ K + E + L+ ++++++ NL+ K + L ++ S
Sbjct: 1415 YEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 659 HEY---NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQQ----KAEFS 710
+Y +R ++E ++ + R L L++K T K+ E++ K +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 711 DQKHQKEIENMCLKTS--QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
H+ E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQA 1589
Query: 769 SKDASLVTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
+ + QR L ++ + A + + + + L+AD +
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------ 1643
Query: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV----- 878
++ R ++++ + Q QM D Q++ E+ + EI +EN KA+ + +
Sbjct: 1644 IKGREEAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 879 ---AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
AE +++ + L+++ A + +A +LS + E + L ++ + E++E + +
Sbjct: 1703 LAAAERARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 936 LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN------------------- 976
+ D +++ +E LS E S N+ ++L ++N
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1820
Query: 977 GTLKEINASLNQEKMNLIQKS---ESFANYIDEREKSISEL----------SDQYKQEKL 1023
T+ + A + Q + + Q++ ++ + +++K + E+ ++QYK++
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ 1083
R ++ E+ ++ + KL+ L+E T E E+ LK + ++
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 140 bits (352), Expect = 3e-32
Identities = 231/1141 (20%), Positives = 470/1141 (41%), Gaps = 147/1141 (12%)
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
++E ++ D+L KT++ + + L+ ++++ +L EEK L +L + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695
+ L +K LE L + + E +R + L+ +R+ ++ ++ +L L+ + E
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAAR 973
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
QKL ++ +A+ +K + EI M + ++L+ + + LE ++ L+ + +++ ++
Sbjct: 974 QKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-----PAMHHSFANI---IGEQGSM 807
L ++ + L E ++ L ++ H A++ I E
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 808 PSERSE------CRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQ---- 852
+++ E RL+ + + KN+A+ L+ + L+ L+S++ + +KQ
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS----KLQEDTSAHQNVVAET----LS 904
EEL +K E+E+ L + Q A+ Q ++ L E+T +H+ V E
Sbjct: 1152 GEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISL 964
A+E ++L+ Q L+K N L L+ L + + +KK++ +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---- 1266
Query: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE-------KSISELSDQ 1017
+++EL + + A LN + L + ES ++E E K ++ LS Q
Sbjct: 1267 ---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ + +L + + N +S K + +E+ + L+ L+E +N + + L
Sbjct: 1324 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1078 FA---KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
+ K+ Q+F + + EE + E+E + Q + K++ L+QE+
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELDD 1438
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVM-KTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
L + + ++ V++L ++ + +++ + K+ E R + RE E +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1194 MD--LEVKEISLDSYNAQL-VQLEAMLRNKE---LKLQESEKEKECLQHELQTIRGDLET 1247
++ LE KE L+ N L ++E ++ +K+ + E EK K L+ +++ ++ LE
Sbjct: 1499 LEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC 1307
++Q+ E + L+ ++ + + G E D + + Q
Sbjct: 1558 LE-DELQATEDAKLR---LEVNMQALKGQFERDLQARDEQNEEKRRQ------------- 1600
Query: 1308 EILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG 1367
LQ + +E TEL D R + A + G L ++++ D + I G
Sbjct: 1601 --LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSA----------IKGR 1647
Query: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427
E E + + D E S E+ E ++K SL+++
Sbjct: 1648 E--EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD---------- 1695
Query: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS-SCVPDSSS 1486
+ +LQ E+L + R Q DL KE L E L SLS + + D
Sbjct: 1696 ----LMQLQ--------EDLAAAERARK-QADLEKE---ELAEELASSLSGRNALQDEKR 1739
Query: 1487 LSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546
+ L E+ G+M +S+ + L E T + T
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ--------AEQLSNELATERSTAQKNE 1791
Query: 1547 KGVEELESLCEVYRQSLEKLE----EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602
++LE + R L ++E K +S +I +LE+ + E +E K
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQ--------TEQLSLELEVARLQLQGLDLSSRS 1654
++++ ++ L V E E K+A + K+ +QL +LE A + Q ++ + R
Sbjct: 1852 KQKDKKLKEILLQV--EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 1655 L 1655
L
Sbjct: 1910 L 1910
Score = 117 bits (293), Expect = 2e-25
Identities = 229/1150 (19%), Positives = 473/1150 (41%), Gaps = 122/1150 (10%)
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
++ L + T + + A+ + KE++ + N+ E EQ Q ++ N L E E
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 944 LQLLSET------LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL---I 994
+L +E L+ +K+E+ I+ + +EE L+ + Q+ ++L +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 995 QKSESFANYID----EREKSISELSDQ----------YKQEKLILLQRCEETGNAYEDLS 1040
++ E+ + E I +L D+ +E+ +L +R + +
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 1041 QKYKAAQEKNSKLECLLNECTSLC---ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
+K K + +K E +++E E + ELE+LK + +F ++A + +
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 1098 NLMLELETVQQALRSEMT------DNQNNSKSEAGGLKQEIMTLKEE-------QNKMQK 1144
L ++L ++ L++ + +NN+ + L+ I L+E+ +NK +K
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
+ DL +E ++ +KT+ E L+S + ++ + E+ K +D E +
Sbjct: 1147 QKRDLGEE----LEALKTELE-DTLDSTATQQELRAKR-EQEVTVLKKALDEETR----- 1195
Query: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264
S+ AQ+ ++ +L E ++ + + L + LE N + G
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 1265 EIDAEEKYISGP-HELSTSQNDNAHLQCSLQTTMNKL-NELEKICEIL---QAEKYELVT 1319
E++ ++K + EL + +D + L ++KL NE+E + +L + + +L
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 1320 ELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
++ S+ + EE + LN +++ L ++ L +L E++ +Q E+
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME----AKQNLER 1371
Query: 1377 HPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
H +S + S+S + L ++ L+E Q E + L Q+ + ++ +L+
Sbjct: 1372 H-ISTLNIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
+ L+ E L +L N Q LV ++ ++ L + SS + D +
Sbjct: 1427 KTKNRLQQELDDLVVDLDN-QRQLVSNLE--KKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1497 RALLEQTGDMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE---- 1551
A ++T +SL LE A+ A + + E+ ++ K+ +E+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
LE+ E + LE+LE+++++ K + ++ L ++L +Q NE+ ++
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ----NEEKRR 1599
Query: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC 1671
+L E E++L E+KQ + A+ +L+G DL L + + AI+GR E+
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAA----AAKKKLEG-DLKD---LELQADSAIKGREEAI 1651
Query: 1672 DISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNY 1731
++ ++ K ++ D A +D K E A + Q
Sbjct: 1652 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 1732 EPPGEDKTQGSSECISEL--SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + E EL S SG NAL Q++ L+ R+ + E
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNAL--------QDEKRRLEARIAQLEEE------- 1751
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL-EY 1848
+E+ +E++ + +++ + +L T+ + E +L+++N +L KL E
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLDVENELSR 1906
+ + E + LE ++ +RE ++ + + KE L VE+E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1907 IRSEKASIEH---EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
K E L+ LE + E ++ N N++K L+ EL T +
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRK----LQRELDEATESNEAM 1924
Query: 1964 RGELDTMSKK 1973
E++ + K
Sbjct: 1925 GREVNALKSK 1934
Score = 85.9 bits (211), Expect = 6e-16
Identities = 121/550 (22%), Positives = 225/550 (40%), Gaps = 72/550 (13%)
Query: 4 ALEEWKEGLPTRA---LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN--- 57
ALEE K+ Q+ +E DKL+K K + Q +LD L L Q+Q V N
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 58 --------------------------------EKTEGTNLKRENQRLMEICESLEKTKQK 85
++T+ +L R + +E E LE+T +
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 86 ISHELQ---VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
+ E++ + V +L K+ +E +E+K ELE QA + A + L
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 143 NTPQK-IFTTPLTPSQYYSGSKYEDLKEK---YNKEVEE-----------RKRLEAEVK- 186
K F L + K L+ + Y E+E+ +K+LE ++K
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 187 -ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
LQA A + +A R + QA F Q + +S + ++
Sbjct: 1636 LELQADSAIKGREEAIKQLRKL---QAQMKDF---QRELEDARASRDEIFATAKENEKKA 1689
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S E ++ + L +R + + L + L+++ LE R+ E
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1749
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK-- 363
+E++ + + + ++ KA + E++ N+ E R+TAQ ++++ + + K
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQA---EQLSNELATE--RSTAQKNESARQQLERQNKEL 1804
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
KL E + +S +LE KI + E++ ++E +Q + ++L Q+ ++K L Q
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE 483
++ + M + + +K + +QL+ LEE +++ R + Q + +E S E
Sbjct: 1865 -VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 484 MKKENNLLKS 493
M +E N LKS
Sbjct: 1924 MGREVNALKS 1933
Score = 73.2 bits (178), Expect = 4e-12
Identities = 86/423 (20%), Positives = 196/423 (46%), Gaps = 61/423 (14%)
Query: 2516 KLEKKDEEISRLKNQIQD----QEQLVSKLSQVEGEH-QLWKEQNL-------------E 2557
++ +++EE+ ++++Q Q++ ++L ++E +H QL +E+NL E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
+ V L K Q L+ ++ LE + + L+ E + + E++ + A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 2618 ETELQREMHEMAQKTAELQEE---LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
+LQ E K +L++E + + N+L+ E +LL E I L E E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE------EE 1026
Query: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
+K+ K+ + + K I+E ++RL + EK Q L ++ E + + E++
Sbjct: 1027 EKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIAD 1080
Query: 2735 KEECLSSQKLEI----DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
+ ++ K+++ + L+++ L++ + L+++++ + +++ L+++ +
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDLDS 1136
Query: 2791 AQGKMKLLIKSCKQLEEEKEILQKEL--------SQLQAAQEKQKTGTVMDTKVDELT-- 2840
+ K + L EE E L+ EL +Q + ++++ TV+ +DE T
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 2841 --TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ-----QS 2893
+++E+++ + +E E L+++ + L+K K+ LE + A L + Q+
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKR---AKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 2894 KQD 2896
KQ+
Sbjct: 1254 KQE 1256
Score = 35.8 bits (81), Expect = 0.68
Identities = 24/114 (21%), Positives = 54/114 (47%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
KI +LE Q+++ +EKQ L + L++ +VE+E+ K + ++ +
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
L++ ++ E Q + + +L+ + E + +E+ KS+L R + +
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 195 bits (495), Expect = 7e-49
Identities = 229/1010 (22%), Positives = 470/1010 (46%), Gaps = 105/1010 (10%)
Query: 1926 EVVQTEKLCLEKDNENKQKV---IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
E +Q ++ L+K E +QK + LE++ S +T E+N L+ +L ++ +++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
++ K QELE E LH EA ++E+ + Q L ++ ++ + L+E+L+ E
Sbjct: 919 RLAAKKQELE----EILH---EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 2043 DSQALSLTKC-------ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095
Q L L K +LE++I ++ + L KE + L+ R+S+ L
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-----------LTT 1020
Query: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS---- 2151
L E+ E A L+ + + + I +L VR++ +EK + + EKLK R+ E D+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQEL-EKLK-RKLEGDASDFH 1075
Query: 2152 -----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
L+ ++ L+ +L EE + + ++ A+ +I E+ + + DL
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQL 2265
+ R+ + KQ K+ EL+ L + + L+ Q E++ K E + V +L+ L
Sbjct: 1136 SERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--VTVLKKAL 1190
Query: 2266 KELNEAVAALCGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCV 2320
E + A + Q+ +A E+ L +E+ + + +++K + LE AD +L V
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEE-LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
L Q K+ H K ++E +EL+ ++ E A E + +V L+ ++E +T L
Sbjct: 1250 LGQAKQEVEHK---KKKLEAQVQELQSKCSDGERARAELND---KVHKLQNEVESVTGML 1303
Query: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
E + + + +L+++LQ QE + E + L++ E+E+ ++++ M
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ-------LLQGLDEAK 2493
E Q L ++ L+ K K Q+ +S VE LE K + L Q +E
Sbjct: 1364 EAKQ----NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Y L+ + N L QE++D L+ + + +S L+ + + +QL+++ + ++ ++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
+ E + + ++K SL LE + LE + EL + +KM E +
Sbjct: 1480 R----------AEAEAREKETKALSLARALE------EALEAKEELERTNKMLKAEMEDL 1523
Query: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
+++K+ ++ + +HE+ + L+ ++ K +L+ L +E+++++D L +
Sbjct: 1524 VSSKD-DVGKNVHELEKSKRALETQMEEMKT----QLEELEDELQATEDAKLRLEVNMQA 1578
Query: 2674 LK----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
LK + L + EK +++ ++ EY+ L E E+K +AL K+ E +++
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL-EDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
+ S + ++ L++ ++ L+ +E+ T +N K L+ +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVMDTKVDELTTEIKE--- 2845
+ Q + ++ KQ + EKE L +EL S L Q ++ ++ +L E++E
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 2846 ----LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
+ + + + T++A++ ++ + + +K E A++ LE Q L S+
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Score = 188 bits (477), Expect = 8e-47
Identities = 244/1116 (21%), Positives = 480/1116 (43%), Gaps = 164/1116 (14%)
Query: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL 1846
L ++R +K E+ L E+++ S+L ++ L +++A EL E++ + ++L
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
E E+L EM A ED G + ++ LD+E +L
Sbjct: 928 E-------EILH------------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVT--------- 1957
+ + ++ E + EA ++ ++ E L ++ N K LEE +S +T
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 1958 --------SERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
++ + EL+ KK Q EK+K K + S E + +Q AE+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 2010 K----EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN--- 2062
K +K E LQ + + + + K + +K++ LE +S + +L+++ A N
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQEDLDSERAARNKAE 1145
Query: 2063 KEKELLVKESESLQARL-----SESDYEKLNVSKALEAALVEKG---EFALRLSSTQEEV 2114
K+K L +E E+L+ L S + ++L + E +++K E + QE
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSL----------KDKVENLERELQ 2164
+ + +E+L ++E ++ + ++ + + E+EN L K +VE+ +++L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 2165 MSEENQELVILDAENSKAE----VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
+ + D E ++AE V L+ ++E + L E + L + +L+ Q+Q
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 2221 EKQGQLSE--------------LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
+ Q L E L++ +S + L+E+ +A+ ++ T L + K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 2267 ELNE---AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD---------- 2313
+L + V AL ++ + ++L EE+ + +EK + RL+ +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 2314 --------EKKQLCVLQQLKE----SEHHADLLKGRVENLERELEIARTNQEHAALEAEN 2361
EKKQ Q L E S +AD + R E RE E + A EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALE 1504
Query: 2362 SKGEVE----TLKAKIEGMT--------------QSLRGLELDVVTIRSEKENLTNELQK 2403
+K E+E LKA++E + +S R LE + ++++ E L +ELQ
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 2404 EQERISELEI----INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
++ LE+ + FE LQ ++++ + + + LQ QL E +
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-------LQRQLHEYETELEDERK 1617
Query: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
+ A ++ L ++ LEL+ ++G +EA LQ+ + +E+ED +
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR---AS 1674
Query: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGE----HQLWKEQNLELRNLTVELEQKIQVLQSK 2575
+DE + K + + L + L Q++ + + K+ +LE L EL L +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS---LSGR 1731
Query: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM---HEMAQKT 2632
NA LQD L++ LE ELE + + + ++V K T + +L E+ AQK
Sbjct: 1732 NA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 2633 AELQEELSGEKNRLAGELQLLLEEIKSS-KDQLKELTLENSELKKSLDCMHKDQVEKEGK 2691
+++L + L +L + +KS K + L + ++L ++QVE+E +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL--------EEQVEQEAR 1842
Query: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751
++ + L + +KK + +LL + ++ Q Y+E+ + K +++ +
Sbjct: 1843 EKQAATK---SLKQKDKKLKEILLQVEDERKMAEQ-YKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 2752 SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2787
+ +N + + + L+E ++ + VN LK +
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 174 bits (441), Expect = 1e-42
Identities = 248/1185 (20%), Positives = 507/1185 (42%), Gaps = 126/1185 (10%)
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
T P V E + L+K +E+ + E++ELEQ S +E + L++
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQE 901
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
Q +E E + + EM +LAA+K++ E++ E+E ARL+ +
Sbjct: 902 QLQAETELYAE-----AEEMRVRLAAKKQELEEILHEME-ARLE--------------EE 941
Query: 1661 EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE 1720
ED R + ++ ++ D+ + +++ L +EK+T +K E
Sbjct: 942 ED----RGQQLQAERKKMAQQML-----DLEEQLEEEEAARQKLQLEKVTAEAKIKKL-E 991
Query: 1721 CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETS 1780
D N + E K E IS+L+ + +E NL +
Sbjct: 992 DEILVMDDQNNKLSKERKLL--EERISDLT---------TNLAEEEEKAKNLT----KLK 1036
Query: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKL-------HLQEVQLMTKI-EACIELEKIV 1832
N++ ++ +E R +K E E+++L KL H Q L +I E ++L K
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDS 1892
EL+ + L +++ L+++ EG SDL+ ED+ A N +
Sbjct: 1097 EELQAALARLDDEI----AQKNNALKKIRELEGHISDLQ--------EDLDSERAARNKA 1144
Query: 1893 WKERFLDVENELSRIRSE-----KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
K++ D+ EL +++E ++ + L + + EV +K E+ ++ +V
Sbjct: 1145 EKQK-RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007
++ V +L +L+ + LD+ + ++++ +L Q E
Sbjct: 1204 MRQKHAQAV----EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
+ K+ +Q L S S+ + + L +K+ L+ + ++++ E E + +L K+
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
L + + Q L E +KLNVS L E+ +L E L R I L ++
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
+ +KK A ++ E + ++ENL ++ + + + + E++ L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 2188 KTQIE---EMARSLKVFELDLVTLRSEKENL-TKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
++ ++ +L+ + L +E++N+ +K E+ +E + + SL
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
E+A ++ KEE + +ML+ ++++L + + + ++ ++++L+ +EE ++ +
Sbjct: 1500 EEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE---MKTQL 1555
Query: 2304 EKLRARLEA--DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH-AALEAE 2360
E+L L+A D K +L V Q + + DL +N E+ ++ R E+ LE E
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 2361 -NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
+ K K+EG L+ LEL + ++ +E I +L + + +
Sbjct: 1616 RKQRALAAAAKKKLEG---DLKDLELQA----------DSAIKGREEAIKQLRKLQAQMK 1662
Query: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
+ +E E + E +TA E + + K L + L D A + + + E L
Sbjct: 1663 DFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
E A L G + ++ L++ + L +E+E+ + +E + R++ Q EQL +
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD---RVRKATQQAEQLSN 1778
Query: 2540 KLS-------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
+L+ + E Q + QN ELR+ E+E ++ + + T+ L++
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALEAKIAQ 1832
Query: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
LE ++E +K + + + + K E+ ++ E +K AE +E + + N +L+
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 2653 LLEEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVR 2693
LEE + ++ ++L E E +S + M ++ + K+R
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 162 bits (410), Expect = 5e-39
Identities = 239/1154 (20%), Positives = 487/1154 (42%), Gaps = 124/1154 (10%)
Query: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
LQK +E + + + KE +Q+ QL + LQ+Q Q T L E + +
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-------AETELYAEAEEMRVRL 920
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
+ ++ ++I HE++ + + + QL + +K K+ Q++ + +LE + A Q
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQK-- 975
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVKALQAKK 192
+ L KI K ED + ++ NK +ERK LE + L
Sbjct: 976 LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
A + + +H+ S+ S + + S + ++R +++
Sbjct: 1023 AEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
++ + K + ++ LD AQ KI ELE GH +++ +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDL 1134
Query: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
+ + + + EK K +L E+ + L ++ + +TA + K EQ++ L + L
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK---REQEVTVLKKALD 1191
Query: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
+ ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENADLAGEL 1247
Query: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
VL ++ K++LE ++E + K E+A K ++L+ +E + N +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
+ + A++V L ++L++ +Q +E + + T LR L+E+ N ++ L
Sbjct: 1308 GKAIKLAKDVASLSSQLQD-------TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 553 LE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
E L+ ++ L Q S+ L+ +E L + + +KE + L E K
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKSHEY--- 661
Y++L++ K + E + L+ ++++++ NL+ K + L ++ S +Y
Sbjct: 1421 AYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 662 NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQ----QKAEFSDQKHQK 716
+R ++E ++ + R L L++K T K+ E++ K + H+
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 717 EIENMCLKT--SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL + +
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNE 1595
Query: 775 VTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
QR L ++ + A + + + + L+AD + ++ R +
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------IKGREE 1649
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV--------AET 881
+++ + Q QM D Q++ E+ + EI +EN KA+ + + AE
Sbjct: 1650 AIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+++ + L+++ A + +A +LS + E + L ++ + E++E + + + D +
Sbjct: 1709 ARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
++ +E LS E S N+ ++L ++N KE+ + L++ + + K F
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSK---FK 1820
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
+ I E I++L +Q +QE E A + L QK K L E
Sbjct: 1821 STIAALEAKIAQLEEQVEQE-------AREKQAATKSLKQKDKK-----------LKEIL 1862
Query: 1062 SLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118
E+ + EQ KE K + ++ +L AEE +Q + +Q+ L E T++
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-DEATESN 1921
Query: 1119 NNSKSEAGGLKQEI 1132
E LK ++
Sbjct: 1922 EAMGREVNALKSKL 1935
Score = 159 bits (402), Expect = 4e-38
Identities = 238/1174 (20%), Positives = 498/1174 (42%), Gaps = 145/1174 (12%)
Query: 324 KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
K +++ +E+ + DEL +T + +A + LEQK +LTE+ +N +
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-----KNLLQEQL 903
Query: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
E ++ + +E + L+ ++ Q L++ +M+ARL +E + + LQAE K+
Sbjct: 904 QAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQ----LQAERKKMA 956
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
LE LEE E A Q Q+++ +++++ E ++ + + ++E
Sbjct: 957 QQMLDLEEQLEE-------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS-LTLEKLKLAVAD 562
LE + ++ L + + A+ + E+M+ +L+ ++ ++E S LEKLK
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK---RK 1066
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCW 622
LE + + + I +L +L+K E+E +A L+ L+ +E+ ++
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQKNNAL--- 1117
Query: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
+ L+ I+ L+ L +++ ++ ++ R L + E L E L
Sbjct: 1118 ------------KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1162
Query: 683 HNVLDSKSVEVETQKLAYME---LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+ LDS + + E + E L++ + + H+ +++ M K +Q VE+L +L
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEELTEQL 1219
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN 799
+ + D+ Q L E L L+ +L +Q H
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELR---------------VLGQAKQEVEH----- 1259
Query: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
++ + ++ E + + + A L ++V L+ +ES M ++ + + +L +
Sbjct: 1260 ---KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 860 KGEIEENLMKAEQMHQSFVAE---TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
+ L +++ Q + S ++ +L+E+ ++ Q+ + E + A +N E+ + L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
N ++ + ++Q+ + LE+ K Q E L+ + +E ++ ++ L QE
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 977 GTLKEINASLNQEKMNLIQKSESF-----------ANYIDEREKSISELSDQYKQEKLIL 1025
L + Q NL +K F + Y DER+++ +E ++ + + L L
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSL 1495
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+ EE A E+L + K + +++E L++ + +N +ELE+ K A + +E
Sbjct: 1496 ARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEM 1551
Query: 1086 LTKLAFAEER---NQNLMLELETVQQALRSEM-TDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
T+L E+ ++ L LE QAL+ + D Q + +Q L E + +
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHE--CQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
++ E ++ L K K E ++LE + +++K RE Q K Q ++
Sbjct: 1612 LEDE-----RKQRALAAAAKKKLEGDLKDLELQ-ADSAIKGREEAIKQLR-KLQAQMKDF 1664
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-----RGDLETSNLQDMQ 1254
+ L+ A ++ A + E K + E + LQ +L + DLE L +
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 1255 SQEISG---LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
+ +SG L+D + E + EL Q + + ++ + +L
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------ 1778
Query: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
EL TE + ++ + R+ E K L L++ G + + I E
Sbjct: 1779 ----ELATERSTAQKN--ESARQQLERQNKELRSK--LHEMEGAVKSKFKSTIAALE--- 1827
Query: 1372 QPNEQHPVSLAPLDESNSYE--HLTLSDKEVQMHFAELQEKFLSLQSEHKILH---DQHC 1426
+A L+E E + K ++ +L+E L ++ E K+ +Q
Sbjct: 1828 -------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
+ ++++ +L+ ++ + E+ ++ N R Q +L
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 149 bits (376), Expect = 4e-35
Identities = 239/1095 (21%), Positives = 442/1095 (40%), Gaps = 161/1095 (14%)
Query: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQKQKQ 53
+A +++ELE + +L +EK Q QL + LE L + +
Sbjct: 877 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 936
Query: 54 KVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLN--SGKKQI 111
++E E+ G L+ E +++ + Q + E Q++E + Q+ QL + + +I
Sbjct: 937 RLEEEEDRGQQLQAERKKMAQ---------QMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987
Query: 112 EKLEQEL-----KRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED 166
+KLE E+ + K ER + +D++ N +K LT + S +
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK--AKNLTKLKNKHESMISE 1045
Query: 167 LKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226
L+ + KE + R+ LE + L+ A+ H IA QA + Q K
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEG--------DASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 227 HLSS------------NSQRTPIRRDFSASYFSGEQEVTPS----RSTLQIGKRDANSSF 270
L + N+ IR + S QE S R+ + KRD
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 271 FDNSSSPHLLDQLK--AQNQELRNKINE--------LELRLQGHEKEMKGQVNKF----Q 316
+ L D L A QELR K + L+ + HE +++ K +
Sbjct: 1156 --EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 317 ELQLQLE---KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
EL QLE +AK L + ++ L K +L QA + ++KL+ ++L
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 374 QRQNAESARCSLEQKIKEKEKEFQE--------------------ELSRQQRSFQTLDQE 413
+ + E AR L K+ + + E + LS Q + Q L QE
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
+ K ++ +L+Q + N LQ +LD+ KQ LE ++ +L +++ Q
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
L + +KE L E+KA A +++ N+ Q +++ +Q
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKA-------AAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 534 ETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593
++ +L++K + + L EK + S +R+ + +K +K
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEK------------NISSKYADERDRAEAEAREKETKALS 1494
Query: 594 ESKALLSALELK---KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
++AL ALE K ++ + LK E K + K + ++E K L++++ ++T
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 651 LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
L+ + + + LE++ + L + D ++ E Q + + + E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELE 1613
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----SLRDL 766
D++ Q+ + K +L G ++DLE + + + + L A+ + L D
Sbjct: 1614 DERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 767 LKSKDASLVT---NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPK 823
S+D T NE +SL A Q + A +Q + E L + S +
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 824 NS-----AILQNRVDSLEFSLESQ----KQMNSDLQKQCEELVQIKGEI---EENLMKAE 871
N+ L+ R+ LE LE + + M+ ++K ++ Q+ E+ K E
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK 931
Q + + SKL E A ++ T++ALE K +L+ ++VE E E Q
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAAT 1848
Query: 932 KSNHLLEDSLKELQL-------LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
KS + LKE+ L ++E + ++ ++ + KR++EE +E+ + INA
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINA 1905
Query: 985 SLNQEKMNLIQKSES 999
+ + + L + +ES
Sbjct: 1906 NRRKLQRELDEATES 1920
Score = 141 bits (355), Expect = 1e-32
Identities = 219/1139 (19%), Positives = 477/1139 (41%), Gaps = 124/1139 (10%)
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
++E ++ D+L KT++ + + L+ ++++ +L EEK L +L + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695
+ L +K LE L + + E +R + L+ +R+ ++ ++ +L L+ + E
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAAR 973
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
QKL ++ +A+ +K + EI M + ++L+ + + LE ++ L+ + +++ ++
Sbjct: 974 QKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-----PAMHHSFANI---IGEQGSM 807
L ++ + L E ++ L ++ H A++ I E
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 808 PSERSE------CRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQ---- 852
+++ E RL+ + + KN+A+ L+ + L+ L+S++ + +KQ
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS----KLQEDTSAHQNVVAET----LS 904
EEL +K E+E+ L + Q A+ Q ++ L E+T +H+ V E
Sbjct: 1152 GEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISL 964
A+E ++L+ Q L+K N L L+ L + + +KK++ +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---- 1266
Query: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE-------KSISELSDQ 1017
+++EL + + A LN + L + ES ++E E K ++ LS Q
Sbjct: 1267 ---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ + +L + + N +S K + +E+ + L+ L+E +N + + L
Sbjct: 1324 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1078 FA---KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
+ K+ Q+F + + EE + E+E + Q + K++ L+QE+
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELDD 1438
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVM-KTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
L + + ++ V++L ++ + +++ + K+ E R + RE E +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1194 MD--LEVKEISLDSYNAQL-VQLEAMLRNKE---LKLQESEKEKECLQHELQTIRGDLET 1247
++ LE KE L+ N L ++E ++ +K+ + E EK K L+ +++ ++ LE
Sbjct: 1499 LEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH------LQCSLQTTMNKLN 1301
++Q+ E + L+ ++ + + G E D + LQ L +L
Sbjct: 1558 LE-DELQATEDAKLR---LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 1302 ELEKICEILQAEKYELVTELND----------SRSECITATRKMAEEVGKLLNEVKILND 1351
+ K + A K +L +L D R E I RK+ ++ E+ +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL----E 1669
Query: 1352 DSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD---KEVQMHFAELQ 1408
D+ E+ + NE+ SL D E L ++ K+ + EL
Sbjct: 1670 DARASRDEIFAT-------AKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
E+ S S L D+ ++ +++++L+ ++ + +S +R + L
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK-----ATQQAEQL 1776
Query: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528
L S++ +S+ + R+ L + + ++ S + ++A + + ++
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEM-EGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL 1588
QE + T S K + E L +V + K+ E+ + Q N +++L
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQV--EDERKMAEQYKEQAEKGNARVKQL---- 1889
Query: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
K+ L E E+ Q++ + +++ +L + E + E+ + +L+G
Sbjct: 1890 -----------KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
Score = 117 bits (294), Expect = 1e-25
Identities = 145/762 (19%), Positives = 331/762 (43%), Gaps = 105/762 (13%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM 73
T L++ + + LDK K+ ++ L L + KQ+VE++K + L+ + Q L
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQ 1272
Query: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
C E+ + +++ ++ +++V G LN + + KL +++ S+L+ +Q+ Q
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
E+ ++K N + R +LE E +LQ
Sbjct: 1333 -------------------------------EETRQKLNVSTKLR-QLEEERNSLQ---- 1356
Query: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
L + +++ RH ++ ++ LS + ++ +DF+++ + E+
Sbjct: 1357 -DQLDEEMEAKQNLERHISTLNI----------QLSDSKKKL---QDFASTVEALEE--- 1399
Query: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
+ Q + + + +++ D+L+ L+ ++++L + L +++++ +
Sbjct: 1400 -GKKRFQKEIENLTQQYEEKAAA---YDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLE 1454
Query: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL----------EQK 363
K Q QL L E++ + +K DE R A+ + TK +L +++
Sbjct: 1455 KKQRKFDQL------LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ------EELSRQQRSFQTLDQECIQM 417
L++ + L + ++ S++ + + + E EK + EE+ Q + Q
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 418 KARLTQELQQAK-NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
K RL +Q K LQA ++ ++QL+ L E++ +L + + + +
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
L +++++ + + E+ +++ L+A++K+ ++ L ++ +E+ A E
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 537 LRDLQEKINQQENSLTLEKLKLAVADLEKQ------------RDCSQDLLKKREHHIEQL 584
+ L+ + Q + L + ADLEK+ R+ QD ++ E I QL
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
++L + + +A+ + ++ E+L E +NE Q+E + + L+SK+
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENL--SVEIRNLHNVLDSKSVEVETQKLAYME 702
+ +E +K+ ++ + LE L VE +KS++ + +KL +
Sbjct: 1809 HEMEGAVKS------KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 703 LQQKAEFS-DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
LQ + E ++++++ E + QL Q+E+ E + Q ++
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Score = 117 bits (293), Expect = 2e-25
Identities = 229/1150 (19%), Positives = 473/1150 (41%), Gaps = 122/1150 (10%)
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
++ L + T + + A+ + KE++ + N+ E EQ Q ++ N L E E
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 944 LQLLSET------LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL---I 994
+L +E L+ +K+E+ I+ + +EE L+ + Q+ ++L +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 995 QKSESFANYID----EREKSISELSDQ----------YKQEKLILLQRCEETGNAYEDLS 1040
++ E+ + E I +L D+ +E+ +L +R + +
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 1041 QKYKAAQEKNSKLECLLNECTSLC---ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
+K K + +K E +++E E + ELE+LK + +F ++A + +
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 1098 NLMLELETVQQALRSEMT------DNQNNSKSEAGGLKQEIMTLKEE-------QNKMQK 1144
L ++L ++ L++ + +NN+ + L+ I L+E+ +NK +K
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
+ DL +E ++ +KT+ E L+S + ++ + E+ K +D E +
Sbjct: 1147 QKRDLGEE----LEALKTELE-DTLDSTATQQELRAKR-EQEVTVLKKALDEETR----- 1195
Query: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264
S+ AQ+ ++ +L E ++ + + L + LE N + G
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 1265 EIDAEEKYISGP-HELSTSQNDNAHLQCSLQTTMNKL-NELEKICEIL---QAEKYELVT 1319
E++ ++K + EL + +D + L ++KL NE+E + +L + + +L
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 1320 ELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
++ S+ + EE + LN +++ L ++ L +L E++ +Q E+
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME----AKQNLER 1371
Query: 1377 HPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
H +S + S+S + L ++ L+E Q E + L Q+ + ++ +L+
Sbjct: 1372 H-ISTLNIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
+ L+ E L +L N Q LV ++ ++ L + SS + D +
Sbjct: 1427 KTKNRLQQELDDLVVDLDN-QRQLVSNLE--KKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1497 RALLEQTGDMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE---- 1551
A ++T +SL LE A+ A + + E+ ++ K+ +E+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
LE+ E + LE+LE+++++ K + ++ L ++L +Q NE+ ++
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ----NEEKRR 1599
Query: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC 1671
+L E E++L E+KQ + A+ +L+G DL L + + AI+GR E+
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAA----AAKKKLEG-DLKD---LELQADSAIKGREEAI 1651
Query: 1672 DISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNY 1731
++ ++ K ++ D A +D K E A + Q
Sbjct: 1652 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 1732 EPPGEDKTQGSSECISEL--SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + E EL S SG NAL Q++ L+ R+ + E
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNAL--------QDEKRRLEARIAQLEEE------- 1751
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL-EY 1848
+E+ +E++ + +++ + +L T+ + E +L+++N +L KL E
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLDVENELSR 1906
+ + E + LE ++ +RE ++ + + KE L VE+E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1907 IRSEKASIEH---EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
K E L+ LE + E ++ N N++K L+ EL T +
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRK----LQRELDEATESNEAM 1924
Query: 1964 RGELDTMSKK 1973
E++ + K
Sbjct: 1925 GREVNALKSK 1934
Score = 85.9 bits (211), Expect = 6e-16
Identities = 121/550 (22%), Positives = 225/550 (40%), Gaps = 72/550 (13%)
Query: 4 ALEEWKEGLPTRA---LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN--- 57
ALEE K+ Q+ +E DKL+K K + Q +LD L L Q+Q V N
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 58 --------------------------------EKTEGTNLKRENQRLMEICESLEKTKQK 85
++T+ +L R + +E E LE+T +
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 86 ISHELQ---VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
+ E++ + V +L K+ +E +E+K ELE QA + A + L
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 143 NTPQK-IFTTPLTPSQYYSGSKYEDLKEK---YNKEVEE-----------RKRLEAEVK- 186
K F L + K L+ + Y E+E+ +K+LE ++K
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 187 -ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
LQA A + +A R + QA F Q + +S + ++
Sbjct: 1636 LELQADSAIKGREEAIKQLRKL---QAQMKDF---QRELEDARASRDEIFATAKENEKKA 1689
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S E ++ + L +R + + L + L+++ LE R+ E
Sbjct: 1690 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1749
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK-- 363
+E++ + + + ++ KA + E++ N+ E R+TAQ ++++ + + K
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQA---EQLSNELATE--RSTAQKNESARQQLERQNKEL 1804
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
KL E + +S +LE KI + E++ ++E +Q + ++L Q+ ++K L Q
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE 483
++ + M + + +K + +QL+ LEE +++ R + Q + +E S E
Sbjct: 1865 -VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 484 MKKENNLLKS 493
M +E N LKS
Sbjct: 1924 MGREVNALKS 1933
Score = 73.2 bits (178), Expect = 4e-12
Identities = 86/423 (20%), Positives = 196/423 (46%), Gaps = 61/423 (14%)
Query: 2516 KLEKKDEEISRLKNQIQD----QEQLVSKLSQVEGEH-QLWKEQNL-------------E 2557
++ +++EE+ ++++Q Q++ ++L ++E +H QL +E+NL E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
+ V L K Q L+ ++ LE + + L+ E + + E++ + A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 2618 ETELQREMHEMAQKTAELQEE---LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
+LQ E K +L++E + + N+L+ E +LL E I L E E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE------EE 1026
Query: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
+K+ K+ + + K I+E ++RL + EK Q L ++ E + + E++
Sbjct: 1027 EKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIAD 1080
Query: 2735 KEECLSSQKLEI----DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
+ ++ K+++ + L+++ L++ + L+++++ + +++ L+++ +
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDLDS 1136
Query: 2791 AQGKMKLLIKSCKQLEEEKEILQKEL--------SQLQAAQEKQKTGTVMDTKVDELT-- 2840
+ K + L EE E L+ EL +Q + ++++ TV+ +DE T
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 2841 --TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ-----QS 2893
+++E+++ + +E E L+++ + L+K K+ LE + A L + Q+
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKR---AKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 2894 KQD 2896
KQ+
Sbjct: 1254 KQE 1256
Score = 50.4 bits (119), Expect = 3e-05
Identities = 50/292 (17%), Positives = 122/292 (41%), Gaps = 8/292 (2%)
Query: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
A++++++L+ Q+ ++E + + D + A ++ ++K ++ + + L+ +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE----RSQQA 131
+ + K++++ EL S N + + + +I +LE+EL+ + +E R ++A
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 132 AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Q A+ N T + + Q E + + E + + ++ + AL+AK
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQE 251
A Q Q R+ QA++ + +K L + + G
Sbjct: 1830 IA-QLEEQVEQEARE---KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Query: 252 VTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQG 303
V + L+ + ++ + LD+ N+ + ++N L+ +L+G
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 195 bits (495), Expect = 7e-49
Identities = 229/1010 (22%), Positives = 470/1010 (46%), Gaps = 105/1010 (10%)
Query: 1926 EVVQTEKLCLEKDNENKQKV---IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
E +Q ++ L+K E +QK + LE++ S +T E+N L+ +L ++ +++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
++ K QELE E LH EA ++E+ + Q L ++ ++ + L+E+L+ E
Sbjct: 912 RLAAKKQELE----EILH---EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 2043 DSQALSLTKC-------ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095
Q L L K +LE++I ++ + L KE + L+ R+S+ L
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-----------LTT 1013
Query: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS---- 2151
L E+ E A L+ + + + I +L VR++ +EK + + EKLK R+ E D+
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESM---ISELEVRLKKEEKSRQEL-EKLK-RKLEGDASDFH 1068
Query: 2152 -----LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
L+ ++ L+ +L EE + + ++ A+ +I E+ + + DL
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQL 2265
+ R+ + KQ K+ EL+ L + + L+ Q E++ K E + V +L+ L
Sbjct: 1129 SERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--VTVLKKAL 1183
Query: 2266 KELNEAVAALCGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE---ADEKKQLCV 2320
E + A + Q+ +A E+ L +E+ + + +++K + LE AD +L V
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEE-LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
L Q K+ H K ++E +EL+ ++ E A E + +V L+ ++E +T L
Sbjct: 1243 LGQAKQEVEHK---KKKLEAQVQELQSKCSDGERARAELND---KVHKLQNEVESVTGML 1296
Query: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
E + + + +L+++LQ QE + E + L++ E+E+ ++++ M
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ-------LLQGLDEAK 2493
E Q L ++ L+ K K Q+ +S VE LE K + L Q +E
Sbjct: 1357 EAKQ----NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Y L+ + N L QE++D L+ + + +S L+ + + +QL+++ + ++ ++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
+ E + + ++K SL LE + LE + EL + +KM E +
Sbjct: 1473 R----------AEAEAREKETKALSLARALE------EALEAKEELERTNKMLKAEMEDL 1516
Query: 2614 MTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
+++K+ ++ + +HE+ + L+ ++ K +L+ L +E+++++D L +
Sbjct: 1517 VSSKD-DVGKNVHELEKSKRALETQMEEMKT----QLEELEDELQATEDAKLRLEVNMQA 1571
Query: 2674 LK----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
LK + L + EK +++ ++ EY+ L E E+K +AL K+ E +++
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL-EDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
+ S + ++ L++ ++ L+ +E+ T +N K L+ +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVMDTKVDELTTEIKE--- 2845
+ Q + ++ KQ + EKE L +EL S L Q ++ ++ +L E++E
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 2846 ----LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
+ + + + T++A++ ++ + + +K E A++ LE Q L S+
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Score = 188 bits (477), Expect = 8e-47
Identities = 244/1116 (21%), Positives = 480/1116 (43%), Gaps = 164/1116 (14%)
Query: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL 1846
L ++R +K E+ L E+++ S+L ++ L +++A EL E++ + ++L
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
E E+L EM A ED G + ++ LD+E +L
Sbjct: 921 E-------EILH------------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVT--------- 1957
+ + ++ E + EA ++ ++ E L ++ N K LEE +S +T
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 1958 --------SERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
++ + EL+ KK Q EK+K K + S E + +Q AE+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 2010 K----EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN--- 2062
K +K E LQ + + + + K + +K++ LE +S + +L+++ A N
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH---ISDLQEDLDSERAARNKAE 1138
Query: 2063 KEKELLVKESESLQARL-----SESDYEKLNVSKALEAALVEKG---EFALRLSSTQEEV 2114
K+K L +E E+L+ L S + ++L + E +++K E + QE
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSL----------KDKVENLERELQ 2164
+ + +E+L ++E ++ + ++ + + E+EN L K +VE+ +++L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 2165 MSEENQELVILDAENSKAE----VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
+ + D E ++AE V L+ ++E + L E + L + +L+ Q+Q
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 2221 EKQGQLSE--------------LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
+ Q L E L++ +S + L+E+ +A+ ++ T L + K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 2267 ELNE---AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD---------- 2313
+L + V AL ++ + ++L EE+ + +EK + RL+ +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 2314 --------EKKQLCVLQQLKE----SEHHADLLKGRVENLERELEIARTNQEHAALEAEN 2361
EKKQ Q L E S +AD + R E RE E + A EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALSLARALEEALE 1497
Query: 2362 SKGEVE----TLKAKIEGMT--------------QSLRGLELDVVTIRSEKENLTNELQK 2403
+K E+E LKA++E + +S R LE + ++++ E L +ELQ
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 2404 EQERISELEI----INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
++ LE+ + FE LQ ++++ + + + LQ QL E +
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-------LQRQLHEYETELEDERK 1610
Query: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
+ A ++ L ++ LEL+ ++G +EA LQ+ + +E+ED +
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR---AS 1667
Query: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGE----HQLWKEQNLELRNLTVELEQKIQVLQSK 2575
+DE + K + + L + L Q++ + + K+ +LE L EL L +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS---LSGR 1724
Query: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM---HEMAQKT 2632
NA LQD L++ LE ELE + + + ++V K T + +L E+ AQK
Sbjct: 1725 NA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 2633 AELQEELSGEKNRLAGELQLLLEEIKSS-KDQLKELTLENSELKKSLDCMHKDQVEKEGK 2691
+++L + L +L + +KS K + L + ++L ++QVE+E +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL--------EEQVEQEAR 1835
Query: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751
++ + L + +KK + +LL + ++ Q Y+E+ + K +++ +
Sbjct: 1836 EKQAATK---SLKQKDKKLKEILLQVEDERKMAEQ-YKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 2752 SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2787
+ +N + + + L+E ++ + VN LK +
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 174 bits (441), Expect = 1e-42
Identities = 248/1185 (20%), Positives = 507/1185 (42%), Gaps = 126/1185 (10%)
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
T P V E + L+K +E+ + E++ELEQ S +E + L++
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQE 894
Query: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDT 1660
Q +E E + + EM +LAA+K++ E++ E+E ARL+ +
Sbjct: 895 QLQAETELYAE-----AEEMRVRLAAKKQELEEILHEME-ARLE--------------EE 934
Query: 1661 EDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGE 1720
ED R + ++ ++ D+ + +++ L +EK+T +K E
Sbjct: 935 ED----RGQQLQAERKKMAQQML-----DLEEQLEEEEAARQKLQLEKVTAEAKIKKL-E 984
Query: 1721 CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETS 1780
D N + E K E IS+L+ + +E NL +
Sbjct: 985 DEILVMDDQNNKLSKERKLL--EERISDLT---------TNLAEEEEKAKNLT----KLK 1029
Query: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKL-------HLQEVQLMTKI-EACIELEKIV 1832
N++ ++ +E R +K E E+++L KL H Q L +I E ++L K
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDS 1892
EL+ + L +++ L+++ EG SDL+ ED+ A N +
Sbjct: 1090 EELQAALARLDDEI----AQKNNALKKIRELEGHISDLQ--------EDLDSERAARNKA 1137
Query: 1893 WKERFLDVENELSRIRSE-----KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
K++ D+ EL +++E ++ + L + + EV +K E+ ++ +V
Sbjct: 1138 EKQK-RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007
++ V +L +L+ + LD+ + ++++ +L Q E
Sbjct: 1197 MRQKHAQAV----EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
+ K+ +Q L S S+ + + L +K+ L+ + ++++ E E + +L K+
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
L + + Q L E +KLNVS L E+ +L E L R I L ++
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
+ +KK A ++ E + ++ENL ++ + + + + E++ L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 2188 KTQIE---EMARSLKVFELDLVTLRSEKENL-TKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
++ ++ +L+ + L +E++N+ +K E+ +E + + SL
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
E+A ++ KEE + +ML+ ++++L + + + ++ ++++L+ +EE ++ +
Sbjct: 1493 EEA-LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE---MKTQL 1548
Query: 2304 EKLRARLEA--DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH-AALEAE 2360
E+L L+A D K +L V Q + + DL +N E+ ++ R E+ LE E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 2361 -NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
+ K K+EG L+ LEL + ++ +E I +L + + +
Sbjct: 1609 RKQRALAAAAKKKLEG---DLKDLELQA----------DSAIKGREEAIKQLRKLQAQMK 1655
Query: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
+ +E E + E +TA E + + K L + L D A + + + E L
Sbjct: 1656 DFQRELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
E A L G + ++ L++ + L +E+E+ + +E + R++ Q EQL +
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD---RVRKATQQAEQLSN 1771
Query: 2540 KLS-------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
+L+ + E Q + QN ELR+ E+E ++ + + T+ L++
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALEAKIAQ 1825
Query: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
LE ++E +K + + + + K E+ ++ E +K AE +E + + N +L+
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 2653 LLEEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVR 2693
LEE + ++ ++L E E +S + M ++ + K+R
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 162 bits (410), Expect = 5e-39
Identities = 239/1154 (20%), Positives = 487/1154 (42%), Gaps = 124/1154 (10%)
Query: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
LQK +E + + + KE +Q+ QL + LQ+Q Q T L E + +
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-------AETELYAEAEEMRVRL 913
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
+ ++ ++I HE++ + + + QL + +K K+ Q++ + +LE + A Q
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK---KMAQQMLDLEEQLEEEEAARQK-- 968
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYED----LKEKYNKEVEERKRLEAEVKALQAKK 192
+ L KI K ED + ++ NK +ERK LE + L
Sbjct: 969 LQLEKVTAEAKI-------------KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
A + + +H+ S+ S + + S + ++R +++
Sbjct: 1016 AEEEEKAKNLTKLK-NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
++ + K + ++ LD AQ KI ELE GH +++ +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDL 1127
Query: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
+ + + + EK K +L E+ + L ++ + +TA + K EQ++ L + L
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK---REQEVTVLKKALD 1184
Query: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
+ ++ E+ + QK + +E E+L + +R+ LD+ K L +E
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN----KQTLEKENADLAGEL 1240
Query: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
VL ++ K++LE ++E + K E+A K ++L+ +E + N +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
+ + A++V L ++L++ +Q +E + + T LR L+E+ N ++ L
Sbjct: 1301 GKAIKLAKDVASLSSQLQD-------TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 553 LE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
E L+ ++ L Q S+ L+ +E L + + +KE + L E K
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKE---NLQSKINHLETCLKTQQIKSHEY--- 661
Y++L++ K + E + L+ ++++++ NL+ K + L ++ S +Y
Sbjct: 1414 AYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 662 NERVRTLEMDRENLSVEI-RNLHNVLDSKSVEVETQKLAYMELQ----QKAEFSDQKHQK 716
+R ++E ++ + R L L++K T K+ E++ K + H+
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 717 EIENMCLKT--SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
E L+T ++ Q+E+LE +LQ + + + Q L ++E RDL + +
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNE 1588
Query: 775 VTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
QR L ++ + A + + + + L+AD + ++ R +
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------IKGREE 1642
Query: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEI----EENLMKAEQMHQSFV--------AET 881
+++ + Q QM D Q++ E+ + EI +EN KA+ + + AE
Sbjct: 1643 AIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+++ + L+++ A + +A +LS + E + L ++ + E++E + + + D +
Sbjct: 1702 ARKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
++ +E LS E S N+ ++L ++N KE+ + L++ + + K F
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSK---FK 1813
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
+ I E I++L +Q +QE E A + L QK K L E
Sbjct: 1814 STIAALEAKIAQLEEQVEQE-------AREKQAATKSLKQKDKK-----------LKEIL 1855
Query: 1062 SLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118
E+ + EQ KE K + ++ +L AEE +Q + +Q+ L E T++
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-DEATESN 1914
Query: 1119 NNSKSEAGGLKQEI 1132
E LK ++
Sbjct: 1915 EAMGREVNALKSKL 1928
Score = 159 bits (402), Expect = 4e-38
Identities = 238/1174 (20%), Positives = 498/1174 (42%), Gaps = 145/1174 (12%)
Query: 324 KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
K +++ +E+ + DEL +T + +A + LEQK +LTE+ +N +
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-----KNLLQEQL 896
Query: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
E ++ + +E + L+ ++ Q L++ +M+ARL +E + + LQAE K+
Sbjct: 897 QAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQ----LQAERKKMA 949
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
LE LEE E A Q Q+++ +++++ E ++ + + ++E
Sbjct: 950 QQMLDLEEQLEE-------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS-LTLEKLKLAVAD 562
LE + ++ L + + A+ + E+M+ +L+ ++ ++E S LEKLK
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK---RK 1059
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCW 622
LE + + + I +L +L+K E+E +A L+ L+ +E+ ++
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD------DEIAQKNNAL--- 1110
Query: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
+ L+ I+ L+ L +++ ++ ++ R L + E L E L
Sbjct: 1111 ------------KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1155
Query: 683 HNVLDSKSVEVETQKLAYME---LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+ LDS + + E + E L++ + + H+ +++ M K +Q VE+L +L
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEELTEQL 1212
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN 799
+ + D+ Q L E L L+ +L +Q H
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELR---------------VLGQAKQEVEH----- 1252
Query: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
++ + ++ E + + + A L ++V L+ +ES M ++ + + +L +
Sbjct: 1253 ---KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 860 KGEIEENLMKAEQMHQSFVAE---TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916
+ L +++ Q + S ++ +L+E+ ++ Q+ + E + A +N E+ + L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
N ++ + ++Q+ + LE+ K Q E L+ + +E ++ ++ L QE
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 977 GTLKEINASLNQEKMNLIQKSESF-----------ANYIDEREKSISELSDQYKQEKLIL 1025
L + Q NL +K F + Y DER+++ +E ++ + + L L
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-ETKALSL 1488
Query: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
+ EE A E+L + K + +++E L++ + +N +ELE+ K A + +E
Sbjct: 1489 ARALEEALEAKEELERTNKMLK---AEMEDLVSSKDDVGKN-VHELEKSKRALETQMEEM 1544
Query: 1086 LTKLAFAEER---NQNLMLELETVQQALRSEM-TDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
T+L E+ ++ L LE QAL+ + D Q + +Q L E + +
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHE--CQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
++ E ++ L K K E ++LE + +++K RE Q K Q ++
Sbjct: 1605 LEDE-----RKQRALAAAAKKKLEGDLKDLELQ-ADSAIKGREEAIKQLR-KLQAQMKDF 1657
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-----RGDLETSNLQDMQ 1254
+ L+ A ++ A + E K + E + LQ +L + DLE L +
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 1255 SQEISG---LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
+ +SG L+D + E + EL Q + + ++ + +L
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------ 1771
Query: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
EL TE + ++ + R+ E K L L++ G + + I E
Sbjct: 1772 ----ELATERSTAQKN--ESARQQLERQNKELRSK--LHEMEGAVKSKFKSTIAALE--- 1820
Query: 1372 QPNEQHPVSLAPLDESNSYE--HLTLSDKEVQMHFAELQEKFLSLQSEHKILH---DQHC 1426
+A L+E E + K ++ +L+E L ++ E K+ +Q
Sbjct: 1821 -------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
+ ++++ +L+ ++ + E+ ++ N R Q +L
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 149 bits (376), Expect = 4e-35
Identities = 239/1095 (21%), Positives = 442/1095 (40%), Gaps = 161/1095 (14%)
Query: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQKQKQ 53
+A +++ELE + +L +EK Q QL + LE L + +
Sbjct: 870 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 929
Query: 54 KVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLN--SGKKQI 111
++E E+ G L+ E +++ + Q + E Q++E + Q+ QL + + +I
Sbjct: 930 RLEEEEDRGQQLQAERKKMAQ---------QMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980
Query: 112 EKLEQEL-----KRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED 166
+KLE E+ + K ER + +D++ N +K LT + S +
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK--AKNLTKLKNKHESMISE 1038
Query: 167 LKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226
L+ + KE + R+ LE + L+ A+ H IA QA + Q K
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEG--------DASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 227 HLSS------------NSQRTPIRRDFSASYFSGEQEVTPS----RSTLQIGKRDANSSF 270
L + N+ IR + S QE S R+ + KRD
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRE--LEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 271 FDNSSSPHLLDQLK--AQNQELRNKINE--------LELRLQGHEKEMKGQVNKF----Q 316
+ L D L A QELR K + L+ + HE +++ K +
Sbjct: 1149 --EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 317 ELQLQLE---KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
EL QLE +AK L + ++ L K +L QA + ++KL+ ++L
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 374 QRQNAESARCSLEQKIKEKEKEFQE--------------------ELSRQQRSFQTLDQE 413
+ + E AR L K+ + + E + LS Q + Q L QE
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
+ K ++ +L+Q + N LQ +LD+ KQ LE ++ +L +++ Q
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
L + +KE L E+KA A +++ N+ Q +++ +Q
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKA-------AAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 534 ETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593
++ +L++K + + L EK + S +R+ + +K +K
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEK------------NISSKYADERDRAEAEAREKETKALS 1487
Query: 594 ESKALLSALELK---KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
++AL ALE K ++ + LK E K + K + ++E K L++++ ++T
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 651 LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
L+ + + + LE++ + L + D ++ E Q + + + E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELE 1606
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----SLRDL 766
D++ Q+ + K +L G ++DLE + + + + L A+ + L D
Sbjct: 1607 DERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 767 LKSKDASLVT---NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPK 823
S+D T NE +SL A Q + A +Q + E L + S +
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 824 NS-----AILQNRVDSLEFSLESQ----KQMNSDLQKQCEELVQIKGEI---EENLMKAE 871
N+ L+ R+ LE LE + + M+ ++K ++ Q+ E+ K E
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK 931
Q + + SKL E A ++ T++ALE K +L+ ++VE E E Q
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAAT 1841
Query: 932 KSNHLLEDSLKELQL-------LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
KS + LKE+ L ++E + ++ ++ + KR++EE +E+ + INA
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINA 1898
Query: 985 SLNQEKMNLIQKSES 999
+ + + L + +ES
Sbjct: 1899 NRRKLQRELDEATES 1913
Score = 141 bits (355), Expect = 1e-32
Identities = 219/1139 (19%), Positives = 477/1139 (41%), Gaps = 124/1139 (10%)
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
++E ++ D+L KT++ + + L+ ++++ +L EEK L +L + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695
+ L +K LE L + + E +R + L+ +R+ ++ ++ +L L+ + E
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAAR 966
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
QKL ++ +A+ +K + EI M + ++L+ + + LE ++ L+ + +++ ++
Sbjct: 967 QKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-----PAMHHSFANI---IGEQGSM 807
L ++ + L E ++ L ++ H A++ I E
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 808 PSERSE------CRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQ---- 852
+++ E RL+ + + KN+A+ L+ + L+ L+S++ + +KQ
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS----KLQEDTSAHQNVVAET----LS 904
EEL +K E+E+ L + Q A+ Q ++ L E+T +H+ V E
Sbjct: 1145 GEELEALKTELEDTL-DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISL 964
A+E ++L+ Q L+K N L L+ L + + +KK++ +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---- 1259
Query: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE-------KSISELSDQ 1017
+++EL + + A LN + L + ES ++E E K ++ LS Q
Sbjct: 1260 ---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ + +L + + N +S K + +E+ + L+ L+E +N + + L
Sbjct: 1317 LQDTQELLQEETRQKLN----VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1078 FA---KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
+ K+ Q+F + + EE + E+E + Q + K++ L+QE+
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELDD 1431
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVM-KTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
L + + ++ V++L ++ + +++ + K+ E R + RE E +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 1194 MD--LEVKEISLDSYNAQL-VQLEAMLRNKE---LKLQESEKEKECLQHELQTIRGDLET 1247
++ LE KE L+ N L ++E ++ +K+ + E EK K L+ +++ ++ LE
Sbjct: 1492 LEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 1248 SNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH------LQCSLQTTMNKLN 1301
++Q+ E + L+ ++ + + G E D + LQ L +L
Sbjct: 1551 LE-DELQATEDAKLR---LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 1302 ELEKICEILQAEKYELVTELND----------SRSECITATRKMAEEVGKLLNEVKILND 1351
+ K + A K +L +L D R E I RK+ ++ E+ +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL----E 1662
Query: 1352 DSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD---KEVQMHFAELQ 1408
D+ E+ + NE+ SL D E L ++ K+ + EL
Sbjct: 1663 DARASRDEIFAT-------AKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
E+ S S L D+ ++ +++++L+ ++ + +S +R + L
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK-----ATQQAEQL 1769
Query: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528
L S++ +S+ + R+ L + + ++ S + ++A + + ++
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEM-EGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL 1588
QE + T S K + E L +V + K+ E+ + Q N +++L
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQV--EDERKMAEQYKEQAEKGNARVKQL---- 1882
Query: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
K+ L E E+ Q++ + +++ +L + E + E+ + +L+G
Sbjct: 1883 -----------KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
Score = 117 bits (294), Expect = 1e-25
Identities = 145/762 (19%), Positives = 331/762 (43%), Gaps = 105/762 (13%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM 73
T L++ + + LDK K+ ++ L L + KQ+VE++K + L+ + Q L
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQ 1265
Query: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
C E+ + +++ ++ +++V G LN + + KL +++ S+L+ +Q+ Q
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
E+ ++K N + R +LE E +LQ
Sbjct: 1326 -------------------------------EETRQKLNVSTKLR-QLEEERNSLQ---- 1349
Query: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
L + +++ RH ++ ++ LS + ++ +DF+++ + E+
Sbjct: 1350 -DQLDEEMEAKQNLERHISTLNI----------QLSDSKKKL---QDFASTVEALEE--- 1392
Query: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
+ Q + + + +++ D+L+ L+ ++++L + L +++++ +
Sbjct: 1393 -GKKRFQKEIENLTQQYEEKAAA---YDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLE 1447
Query: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL----------EQK 363
K Q QL L E++ + +K DE R A+ + TK +L +++
Sbjct: 1448 KKQRKFDQL------LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ------EELSRQQRSFQTLDQECIQM 417
L++ + L + ++ S++ + + + E EK + EE+ Q + Q
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 418 KARLTQELQQAK-NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
K RL +Q K LQA ++ ++QL+ L E++ +L + + + +
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
L +++++ + + E+ +++ L+A++K+ ++ L ++ +E+ A E
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 537 LRDLQEKINQQENSLTLEKLKLAVADLEKQ------------RDCSQDLLKKREHHIEQL 584
+ L+ + Q + L + ADLEK+ R+ QD ++ E I QL
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
++L + + +A+ + ++ E+L E +NE Q+E + + L+SK+
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENL--SVEIRNLHNVLDSKSVEVETQKLAYME 702
+ +E +K+ ++ + LE L VE +KS++ + +KL +
Sbjct: 1802 HEMEGAVKS------KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 703 LQQKAEFS-DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
LQ + E ++++++ E + QL Q+E+ E + Q ++
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Score = 117 bits (293), Expect = 2e-25
Identities = 229/1150 (19%), Positives = 473/1150 (41%), Gaps = 122/1150 (10%)
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
++ L + T + + A+ + KE++ + N+ E EQ Q ++ N L E E
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 944 LQLLSET------LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL---I 994
+L +E L+ +K+E+ I+ + +EE L+ + Q+ ++L +
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 995 QKSESFANYID----EREKSISELSDQ----------YKQEKLILLQRCEETGNAYEDLS 1040
++ E+ + E I +L D+ +E+ +L +R + +
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 1041 QKYKAAQEKNSKLECLLNECTSLC---ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
+K K + +K E +++E E + ELE+LK + +F ++A + +
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 1098 NLMLELETVQQALRSEMT------DNQNNSKSEAGGLKQEIMTLKEE-------QNKMQK 1144
L ++L ++ L++ + +NN+ + L+ I L+E+ +NK +K
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
+ DL +E ++ +KT+ E L+S + ++ + E+ K +D E +
Sbjct: 1140 QKRDLGEE----LEALKTELE-DTLDSTATQQELRAKR-EQEVTVLKKALDEETR----- 1188
Query: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264
S+ AQ+ ++ +L E ++ + + L + LE N + G
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 1265 EIDAEEKYISGP-HELSTSQNDNAHLQCSLQTTMNKL-NELEKICEIL---QAEKYELVT 1319
E++ ++K + EL + +D + L ++KL NE+E + +L + + +L
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 1320 ELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
++ S+ + EE + LN +++ L ++ L +L E++ +Q E+
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME----AKQNLER 1364
Query: 1377 HPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
H +S + S+S + L ++ L+E Q E + L Q+ + ++ +L+
Sbjct: 1365 H-ISTLNIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
+ L+ E L +L N Q LV ++ ++ L + SS + D +
Sbjct: 1420 KTKNRLQQELDDLVVDLDN-QRQLVSNLE--KKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1497 RALLEQTGDMSLLSNLEGAVSA-NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE---- 1551
A ++T +SL LE A+ A + + E+ ++ K+ +E+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
LE+ E + LE+LE+++++ K + ++ L ++L +Q NE+ ++
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ----NEEKRR 1592
Query: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESC 1671
+L E E++L E+KQ + A+ +L+G DL L + + AI+GR E+
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAA----AAKKKLEG-DLKD---LELQADSAIKGREEAI 1644
Query: 1672 DISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNY 1731
++ ++ K ++ D A +D K E A + Q
Sbjct: 1645 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 1732 EPPGEDKTQGSSECISEL--SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
E + E EL S SG NAL Q++ L+ R+ + E
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNAL--------QDEKRRLEARIAQLEEE------- 1744
Query: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL-EY 1848
+E+ +E++ + +++ + +L T+ + E +L+++N +L KL E
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLDVENELSR 1906
+ + E + LE ++ +RE ++ + + KE L VE+E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1907 IRSEKASIEH---EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
K E L+ LE + E ++ N N++K L+ EL T +
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRK----LQRELDEATESNEAM 1917
Query: 1964 RGELDTMSKK 1973
E++ + K
Sbjct: 1918 GREVNALKSK 1927
Score = 85.9 bits (211), Expect = 6e-16
Identities = 121/550 (22%), Positives = 225/550 (40%), Gaps = 72/550 (13%)
Query: 4 ALEEWKEGLPTRA---LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN--- 57
ALEE K+ Q+ +E DKL+K K + Q +LD L L Q+Q V N
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 58 --------------------------------EKTEGTNLKRENQRLMEICESLEKTKQK 85
++T+ +L R + +E E LE+T +
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 86 ISHELQ---VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC 142
+ E++ + V +L K+ +E +E+K ELE QA + A + L
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 143 NTPQK-IFTTPLTPSQYYSGSKYEDLKEK---YNKEVEE-----------RKRLEAEVK- 186
K F L + K L+ + Y E+E+ +K+LE ++K
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 187 -ALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
LQA A + +A R + QA F Q + +S + ++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKL---QAQMKDF---QRELEDARASRDEIFATAKENEKKA 1682
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S E ++ + L +R + + L + L+++ LE R+ E
Sbjct: 1683 KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE 1742
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK-- 363
+E++ + + + ++ KA + E++ N+ E R+TAQ ++++ + + K
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQA---EQLSNELATE--RSTAQKNESARQQLERQNKEL 1797
Query: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
KL E + +S +LE KI + E++ ++E +Q + ++L Q+ ++K L Q
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE 483
++ + M + + +K + +QL+ LEE +++ R + Q + +E S E
Sbjct: 1858 -VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 484 MKKENNLLKS 493
M +E N LKS
Sbjct: 1917 MGREVNALKS 1926
Score = 73.2 bits (178), Expect = 4e-12
Identities = 86/423 (20%), Positives = 196/423 (46%), Gaps = 61/423 (14%)
Query: 2516 KLEKKDEEISRLKNQIQD----QEQLVSKLSQVEGEH-QLWKEQNL-------------E 2557
++ +++EE+ ++++Q Q++ ++L ++E +H QL +E+NL E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 2558 LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
+ V L K Q L+ ++ LE + + L+ E + + E++ + A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 2618 ETELQREMHEMAQKTAELQEE---LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
+LQ E K +L++E + + N+L+ E +LL E I L E E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE------EE 1019
Query: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
+K+ K+ + + K I+E ++RL + EK Q L ++ E + + E++
Sbjct: 1020 EKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIAD 1073
Query: 2735 KEECLSSQKLEI----DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
+ ++ K+++ + L+++ L++ + L+++++ + +++ L+++ +
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE----GHISDLQEDLDS 1129
Query: 2791 AQGKMKLLIKSCKQLEEEKEILQKEL--------SQLQAAQEKQKTGTVMDTKVDELT-- 2840
+ K + L EE E L+ EL +Q + ++++ TV+ +DE T
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 2841 --TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ-----QS 2893
+++E+++ + +E E L+++ + L+K K+ LE + A L + Q+
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKR---AKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 2894 KQD 2896
KQ+
Sbjct: 1247 KQE 1249
Score = 50.4 bits (119), Expect = 3e-05
Identities = 50/292 (17%), Positives = 122/292 (41%), Gaps = 8/292 (2%)
Query: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
A++++++L+ Q+ ++E + + D + A ++ ++K ++ + + L+ +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE----RSQQA 131
+ + K++++ EL S N + + + +I +LE+EL+ + +E R ++A
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 132 AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Q A+ N T + + Q E + + E + + ++ + AL+AK
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQE 251
A Q Q R+ QA++ + +K L + + G
Sbjct: 1823 IA-QLEEQVEQEARE---KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Query: 252 VTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQG 303
V + L+ + ++ + LD+ N+ + ++N L+ +L+G
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 187 bits (476), Expect = 1e-46
Identities = 236/1049 (22%), Positives = 495/1049 (47%), Gaps = 138/1049 (13%)
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
EK+ ++ +EEL+ + R +L ++ ++ ++ + L +++ +T+ L +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEK---NDLQLQVQSETENLMDAE 906
Query: 1996 SECLHCIQ---VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
C I+ + EA+VKE TE L+ SEL+ K +L++K SL++D L LT
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQE 2112
++E + + + L +E +L+ +S+ EK ++ +A + L + L ++
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD-------LQVEED 1019
Query: 2113 EVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQEL 2172
+V+ G+ K+ ++ E++ + L++ ++ L+ LE +L+MS+E+
Sbjct: 1020 KVN----GLIKINAKL---EQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES--- 1069
Query: 2173 VILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL-----TKQIQEKQGQLS 2227
I+D EN K ++E E++ + K FEL + + + E + K+I+E Q ++
Sbjct: 1070 -IMDLENDKQQIE------EKLKK--KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
EL++ + + +L + E+ + E +E + +L+E + A +A + +A Q
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSDLARE----LEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 2288 SLDPPIEE---EHQ-LRNSIEKLRARLEADEKKQLCVLQQLKES-EHHADLLKGRVENLE 2342
+ +EE +H+ ++ K +A A+ +Q+ LQ++K+ E LK ++++
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 2343 RELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQ 2402
+E ++ + + + +KAK E TQ + L + ++++ L++ ++
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 2403 KEQERISELEIINSSFENILQEKEQEKVQMKE--KSSTAM-----------EMLQTQLKE 2449
+++ IS+L S + + Q+ E+ K QM+E K+ AM ++L+ Q +E
Sbjct: 1297 EKESLISQL---TKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEE 1353
Query: 2450 LNERVAALHNDQEACKAK--------EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
E A L ++ E + + E LE K +L Q L EA+ N
Sbjct: 1354 EQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN----TE 1409
Query: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL 2561
+ N +E KQ+L+ + E++ R D E+ + + ++ + + + + E +
Sbjct: 1410 TANSKCASLEKTKQRLQGEVEDLMR------DLERSHTACATLDKKQRNFDKVLAEWKQK 1463
Query: 2562 TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETEL 2621
E + +++ Q ++ SL L ++++Y+ + ++LE + + + E+++ +T + E
Sbjct: 1464 LDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAET 1523
Query: 2622 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS----KDQLKELTLENSELKKS 2677
+ + E A+KT +L E+ EK+ +LQ+ LEE++ S + ++ + LE S++K
Sbjct: 1524 GKNLQE-AEKTKKLVEQ---EKS----DLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575
Query: 2678 LD--CMHKD-QVEKEGKVREEIAEYQLRLHEAE--KKHQALLLDTNKQ---YEVEIQ--- 2726
LD + KD ++E+ + + AE + +AE ++ AL L + E+EIQ
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635
Query: 2727 ------TYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ----ILEELKKTKMD 2776
++ L + + L +L +D S E+L L + +LEEL++ K+
Sbjct: 1636 SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV- 1694
Query: 2777 NLKYVNQLKKENER----AQGKMKLLIKSCKQLEEEKEILQKELSQLQA----------- 2821
L+ + ++ +E+ A +++LL L K+ L+ +++Q QA
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 2822 AQEKQK---TGTVMDT----KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
A+EK K T M K + + ++ +K+ LE+ K+ LD+ L + K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK- 1813
Query: 2875 EKAKEMLETQVAHLCSQQSKQDSRGSPLL 2903
K + LE +V L ++ + RG+ L
Sbjct: 1814 -KQIQKLENRVRELENELDVEQKRGAEAL 1841
Score = 178 bits (452), Expect = 6e-44
Identities = 253/1210 (20%), Positives = 522/1210 (43%), Gaps = 170/1210 (14%)
Query: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577
A + ++E S LQE+N + + S E E+L + EE+ E G++K
Sbjct: 872 ARRKELEEKMVSLLQEKNDLQLQVQS-------ETENLMDA--------EERCE--GLIK 914
Query: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637
+K + E + +ER L E E+ +L + +E K ++ K+ + L L
Sbjct: 915 SKILLEAKVKELTER----------LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964
Query: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETT-ERTPKHDVHQICDK 1696
L + TE+ ++ +E +E+ S+ T E+ + HQ
Sbjct: 965 LTKVEKEKHA------------TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQ---- 1008
Query: 1697 DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNA 1756
DL ++ +K+ G +K + +Q+ D E K + E ++ G
Sbjct: 1009 QTLDDLQVEEDKVN--GLIKINAKLE-QQTDDLEGSLEQEKKLRADLER-AKRKLEGDLK 1064
Query: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV 1816
+ + + D ++ ++K+ E +L I+D ++KEL +++ E
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE 1124
Query: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
++ + ++EK +L +E ++SE+LE E S ++ +EM+ +
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLE-------------EASGATSAQIEMNKKR 1171
Query: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-L 1935
+ E + R E+A+++HEA A L Q + + L
Sbjct: 1172 ----------------------EAEFQKMRRDLEEATLQHEA--TAATLRKKQADSVAEL 1207
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL---E 1992
+ +N Q+V LE+E S + E + + ++ +SK + +++ ++++ E+ +
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 1993 SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
Q++ +H + + +A LQT + ++S +++K L + L K QAL+
Sbjct: 1268 EQQTQLIHDLNMQKAR-------LQTQNGELSHRVEEKESL---ISQLTKSKQALTQQLE 1317
Query: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQE 2112
EL+ Q+ + K K + + +LQ+ + D + + EA K E LS
Sbjct: 1318 ELKRQMEEETKAKNAM---AHALQSSRHDCDLLREQYEEEQEA----KAELQRALSKANS 1370
Query: 2113 EVHQLRRGIEKLRV-RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
EV Q R E + R E E+ + +A++L+E E ++ K +LE+ Q + E
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE 1430
Query: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
++ D E S TL + + L ++ L ++E E K E + +EL K
Sbjct: 1431 DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK---ESRSLSTELFK 1487
Query: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
+ ++++ ++++ E ++ E+K LQ ++ +L E +A + + + T++ ++
Sbjct: 1488 MRNAYEEVVDQLE----TLRRENKN----LQEEISDLTEQIAETGKNLQEAEKTKKLVE- 1538
Query: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
+E+ L+ ++E++ LE +E K L V +L + + D +V + E+E + N
Sbjct: 1539 --QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELD---RKVIEKDEEIEQLKRN 1593
Query: 2352 QEHAA------LEAE-NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
+ AA L+AE S+ + LK K+EG L +E+ + + L+
Sbjct: 1594 SQRAAEALQSVLDAEIRSRNDALRLKKKMEG---DLNEMEIQLGHSNRQMAETQKHLRTV 1650
Query: 2405 QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Q ++ + ++ ++ L+ E +KE+ + L+EL E AL +
Sbjct: 1651 QGQLKDSQL---HLDDALRSNE----DLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 2465 KAKEQNL---SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
+ EQ L S +V+ L + L+ + + + Q+ V IQE + ++K +K
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE--LRNLTVELEQKIQVLQSKNASL 2579
+ + + +++ ++ + L ++ ++NLE +++L L++ Q L K
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERM--------KKNLEQTVKDLQHRLDEAEQ-LALKGGKK 1814
Query: 2580 QDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL 2639
Q ++ L++ + LENEL++ + ++ +K K E+ + E + LQ+
Sbjct: 1815 Q--IQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQD-- 1870
Query: 2640 SGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY 2699
L +LQ ++ K ++ +E N++L + C +E R +IAE
Sbjct: 1871 ------LVDKLQAKVKSYKRQAEEAEEQA--NTQLSR---CRRVQHELEEAAERADIAES 1919
Query: 2700 QLRLHEAEKK 2709
Q+ A+ +
Sbjct: 1920 QVNKLRAKSR 1929
Score = 171 bits (432), Expect = 1e-41
Identities = 217/1042 (20%), Positives = 443/1042 (42%), Gaps = 136/1042 (13%)
Query: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL-------HLQEVQLMTK 1821
+ L R++E N L+ + + K SL ++ +L+ L H E ++
Sbjct: 923 VKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNL 982
Query: 1822 IEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1881
E LE+ + +L KE L E HQ+ L DL++ DK +
Sbjct: 983 SEEMTALEENISKLTKEKKSLQEA-------HQQTLD----------DLQVEEDKVN--- 1022
Query: 1882 IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN 1941
+ K+N +++ D+E L + + +A +E LE DL++ Q + LE D +
Sbjct: 1023 ---GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2001
+EE+L E +QL+ ++D + + ++++ + +ELE + E H
Sbjct: 1080 -------IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE-EEIEAEHT 1131
Query: 2002 IQV--------AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL---- 2049
++ E++E +E L+ S S ++ + + Q + +D + +L
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 2050 ----TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
+ + + +A+L ++ + L + + L+ SE E +++ +EA
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA---------- 1241
Query: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKER----ERENDSLKDKVENLER 2161
LS ++ + + R +E I+A +++Q + L + + +N L +VE E
Sbjct: 1242 -LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300
Query: 2162 EL-QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
+ Q+++ Q L ++E LK Q+EE ++ L + R + + L +Q +
Sbjct: 1301 LISQLTKSKQALT--------QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE 1352
Query: 2221 EKQGQLSELDKLLSSFKSLLEE----KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
E+Q +EL + LS S + + E IQ EE + A + L +L+E E
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETAN 1412
Query: 2277 GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCV-------LQQLKESEH 2329
++ T+Q L +E+ L +E+ +KKQ Q+L ES+
Sbjct: 1413 SKCASLEKTKQRLQGEVED---LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQA 1469
Query: 2330 HADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQ-------SLRG 2382
+ + +L EL R E + E + E + L+ +I +T+ +L+
Sbjct: 1470 ELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE 1529
Query: 2383 LELDVVTIRSEK-------ENLTNELQKEQERI----SELEIINSSFENILQEKEQEKVQ 2431
E + EK E + L+ E+ +I EL + S + + EK++E Q
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
+K S A E LQ+ L A + + +A + K++ + + +E++ + + E
Sbjct: 1590 LKRNSQRAAEALQSVLD------AEIRSRNDALRLKKK-MEGDLNEMEIQLGHSNRQMAE 1642
Query: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ----IQDQEQLVSKLSQVEGE 2547
+ + +Q + ++D + E E+++ ++ + +++ E++ L Q E
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERT 1702
Query: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
+L EQ L ++ ++Q+L S+N SL +T + L++ + E+E + + +
Sbjct: 1703 RRL-SEQEL------LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
Query: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEE-----IKSSKD 2662
EK K + E+ + +A L E + + +LQ L+E +K K
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL--LLDTNKQ 2720
Q+++L EL+ LD K E + + + ++AE+ H+ + L D +
Sbjct: 1815 QIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDK 1874
Query: 2721 YEVEIQTYREKLTSKEECLSSQ 2742
+ ++++Y+ + EE ++Q
Sbjct: 1875 LQAKVKSYKRQAEEAEEQANTQ 1896
Score = 164 bits (414), Expect = 2e-39
Identities = 221/1086 (20%), Positives = 478/1086 (44%), Gaps = 131/1086 (12%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + + + K + LE + LK++ + L +E + KV+N E T L+
Sbjct: 931 EEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALE 990
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVN----------FQEGQLNSGKKQIEKLEQ 116
+L + +SL++ Q+ +LQV+E +VN Q L +Q +KL
Sbjct: 991 ENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRA 1050
Query: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE 176
+L+R K +LE + +Q + + L N Q+I L ++ + L+ K + E
Sbjct: 1051 DLERAKRKLEGDLKMSQESIMDLE--NDKQQI-EEKLKKKEF----ELSQLQAKIDDEQV 1103
Query: 177 ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTP 236
+ + ++K LQA+ + A H + + EK S L+ +
Sbjct: 1104 HSLQFQKKIKELQARIEE-------LEEEIEAEHTLRAKI-----EKQRSDLARELEEIS 1151
Query: 237 IRRDFSASYFSGEQEVTPSR-STLQIGKRDANSSFFDNSSSPHLLDQLKAQN-QELRNKI 294
R + ++ S + E+ R + Q +RD + + ++ L + +A + EL +I
Sbjct: 1152 ERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI 1211
Query: 295 NELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
+ L+ Q EKE EL+++++ ++ + L+K + + RT +
Sbjct: 1212 DNLQRVKQKLEKEK-------SELKMEID----DMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
++ A +++ +L DL+ Q+ ++ L +++EKE +S+ +S Q L Q+
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKE----SLISQLTKSKQALTQQL 1316
Query: 415 IQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
++K ++ +E + M + LQ+ +++Q E +E K +L RA
Sbjct: 1317 EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEE-QEAKAELQRA----------- 1364
Query: 475 NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
L ++ E+ + ++ + Q+ E LE K + Q L +++ E +K S E
Sbjct: 1365 --LSKANSEVAQWRTKYETDAIQRTEE---LEEAKKKLAQRLQEAEENTETANSKCASLE 1419
Query: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
+ LQ ++ ++ LE+ A A L+K++ +L + + +++ +L +KE
Sbjct: 1420 KTKQRLQGEV--EDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
S++L + L + YEE+ ++ + EN+ L ++ E + +L+ KT+
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQ---LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534
Query: 655 QIKSHEYNERVRTLE-----MDRE-----NLSVEIRNLHNVLDSKSVEVETQ-KLAYMEL 703
++ E ++ LE ++ E + +E+ + + LD K +E + + +
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 704 QQKAEFSDQKHQKEI--ENMCLK-TSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Q+ AE EI N L+ ++ G + ++E +L + ++ + + + + +
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ- 1653
Query: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
L+D D +L +NED + L +++ G + E E ++ +Q
Sbjct: 1654 --LKDSQLHLDDALRSNEDLKEQLAIVERR-------------NGLLLEELEEMKVALEQ 1698
Query: 821 SPKNSAILQNRV----DSLEFSLESQKQMNSDLQKQCE-ELVQIKGEIEENLMK---AEQ 872
+ + + + + D ++ L SQ + +K+ E ++ Q + E+E ++ + AE+
Sbjct: 1699 TERTRRLSEQELLDASDRVQL-LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 873 MHQSFVAETSQRISKL--QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930
+ + + + +L ++DTSAH + + LE K+LQ D E EQ ++
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKN---LEQTVKDLQHRLD--EAEQLALKGG 1812
Query: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIIS---LNKREIEELTQENGTLKEINASLN 987
KK LE+ ++EL+ L +E+K + + +R+++E+T +
Sbjct: 1813 KKQIQKLENRVRELE---NELDVEQKRGAEALKGAHKYERKVKEMTYQ-----------A 1858
Query: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
+E I + + + + + KS +++ +++ L RC + E+ +++ A+
Sbjct: 1859 EEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAE 1918
Query: 1048 EKNSKL 1053
+ +KL
Sbjct: 1919 SQVNKL 1924
Score = 141 bits (356), Expect = 9e-33
Identities = 165/807 (20%), Positives = 348/807 (43%), Gaps = 109/807 (13%)
Query: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2164
L+ + ++E+ ++ E+ + + E ++ + EK+ +E + L+ +V++ L
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 2165 MSEENQELVILDAENSKAEVETLKTQIEE---------------------MARSLKVFEL 2203
+EE E +I +A+V+ L ++EE + R + EL
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 2204 DLVTLRSEK---ENLTKQIQEKQGQLSE-LDKLLSSFKSLLEEKEQA--EIQIKEESKTA 2257
L + EK EN K + E+ L E + KL KSL E +Q ++Q++E+
Sbjct: 964 TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023
Query: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
+ + +L++ + L+ +E+E +LR +E+ + +LE D K
Sbjct: 1024 LIKINAKLEQQTD-----------------DLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066
Query: 2318 LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMT 2377
+ + + E+ ++ +++ E EL + + + + + +++ L+A+IE +
Sbjct: 1067 ---QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 2378 QSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS 2437
+ + I ++ +L EL++ ER+ E S+ +++M +K
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA-----------QIEMNKKRE 1172
Query: 2438 TAMEMLQTQLKEL---NERVAALHNDQEACKAKE-----QNLSSQVECLELEKAQLLQGL 2489
+ ++ L+E +E AA ++A E NL + LE EK++L +
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Query: 2490 DEAKNNYIVL---QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
D+ +N L +S++ + VED +++ KDE+ Q QL+ L+ +
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ----------QTQLIHDLNMQKA 1282
Query: 2547 EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVL------QSSYKN-LENELEL 2599
Q QN EL + E E I L +L LE L ++ KN + + L+
Sbjct: 1283 RLQ---TQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 2600 TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS 2659
++ D E+ + + ELQR + + + A+ + + + + E LEE K
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEE----LEEAKK 1395
Query: 2660 SKDQLKELTLENSELKKS-LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Q + EN+E S + K + +G+V + + + E+ H A
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED-------LMRDLERSHTACATLDK 1448
Query: 2719 KQ--YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD 2776
KQ ++ + +++KL + L + + E L + ++ N+ + LE L++ +
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508
Query: 2777 NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKV 2836
+ ++ L ++ ++ K+ K +E+EK LQ L +++ + E + ++K+
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE------ESKI 1562
Query: 2837 DELTTEIKELKETLEEKTKEADEYLDK 2863
+ E+ ++K L+ K E DE +++
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Score = 140 bits (354), Expect = 1e-32
Identities = 214/1041 (20%), Positives = 451/1041 (43%), Gaps = 98/1041 (9%)
Query: 290 LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
L K+ EL RL+ E+ V K + L+ + K ++ + E L K E T +
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978
Query: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEK-----EFQEELSRQQ 404
S + TALE+ + KLT++ ++ E+ + +L+ E++K + +L +Q
Sbjct: 979 VKNLSEEMTALEENISKLTKE---KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 405 RSFQ-TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
+ +L+QE +++A L + ++ + + Q + L + KQQ+E L++ + +L +
Sbjct: 1036 DDLEGSLEQE-KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL 1094
Query: 464 EQAFQASQI-------KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
+ Q+ K EL+ +EE+++E + + ++ L EL+ I + L
Sbjct: 1095 QAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERL 1154
Query: 517 NQSQNFAE---EMKAKNTSQ-ETMLRDLQEKINQQE-NSLTLEKLKL-AVADLEKQRDCS 570
++ EM K ++ + M RDL+E Q E + TL K + +VA+L +Q D
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 571 QDLLKKREHHIEQLN----------DKLSKTEKESKALLSALELKKKEYEELKEEKT-LF 619
Q + +K E +L + LSK++ + +E + E + E++T L
Sbjct: 1215 QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD---RENLS 676
+ +L TQ ++ K + + K++Q + + E R +E + + ++
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334
Query: 677 VEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
+++ + D + E ++ A ELQ+ ++ + + Q T ++E+ +
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHS 796
KL E + A E + L+ + L+ D +RS A +
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM--RDLERSHTACATLDKKQRN 1452
Query: 797 FANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQK 851
F ++ E + S+ LEA Q S ++N + + LE+ ++ N +LQ+
Sbjct: 1453 FDKVLAE-WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511
Query: 852 QCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
+ +L + E +NL +AE+ + E S L+E + ++ ++ L +
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ 1571
Query: 912 ELQLLNDKVETEQAEIQELKKSNHLLEDSLK-----ELQLLSETLSLEKKEMSSIISLNK 966
L+ KV + EI++LK+++ ++L+ E++ ++ L L+KK LN+
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG---DLNE 1628
Query: 967 REIE------ELTQENGTLKEINASLNQEKMNL---IQKSESFANYIDEREKSISELSDQ 1017
EI+ ++ + L+ + L +++L ++ +E + E+ L ++
Sbjct: 1629 MEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
Query: 1018 YKQEKLILLQRCEETGNAYE----DLSQKYKAAQEKNS-------KLECLLNECTSLCEN 1066
++ K + L++ E T E D S + + +N+ KLE + +C + E
Sbjct: 1689 LEEMK-VALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE- 1746
Query: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAEE--RNQNLMLELETVQQALRSEMTDNQNN-SKS 1123
N +++ + A K + AEE + Q+ LE +++ L + D Q+ ++
Sbjct: 1747 --NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804
Query: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER-- 1181
E LK +++ +N++++ N+L E ++ + +K H+ + VKE
Sbjct: 1805 EQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYE--------RKVKEMTY 1856
Query: 1182 ESERNQCNFKPQMDLEVK-EISLDSYNAQLVQLE-------AMLRNKELKLQESEKEKEC 1233
++E + N DL K + + SY Q + E + R + +L+E+ + +
Sbjct: 1857 QAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADI 1916
Query: 1234 LQHELQTIRGDLETSNLQDMQ 1254
+ ++ +R Q M+
Sbjct: 1917 AESQVNKLRAKSRDVGSQKME 1937
Score = 127 bits (319), Expect = 2e-28
Identities = 252/1251 (20%), Positives = 497/1251 (39%), Gaps = 194/1251 (15%)
Query: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE 1065
E EK ++ + + +++ K E+L++ +E K+ LL E L
Sbjct: 848 EAEKEMATMKEDFERTK--------------EELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 1066 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEA 1125
++E E L +A +E E L K E + E ++ + SE+ + N + +
Sbjct: 894 QVQSETENLMDA--EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKC 951
Query: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
LK++I L+ K++KE + EN KV E LE E I KE++S +
Sbjct: 952 SSLKRDIDDLELTLTKVEKEKH--ATEN----KVKNLSEEMTALE-ENISKLTKEKKSLQ 1004
Query: 1186 NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL 1245
+ + + DL+V+E ++ +LE + E L++ +K + L+ + + GDL
Sbjct: 1005 -EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDL 1063
Query: 1246 ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEK 1305
+ M + I L++ + EEK ELS Q Q K+ EL+
Sbjct: 1064 K------MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 1306 ICEILQAE---KYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
E L+ E ++ L ++ RS+ +++E L + SG ++
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER----------LEEASGATSAQI-- 1165
Query: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD--KEVQMHFAELQEKFLSLQSEHKI 1420
E ++ + L+E+ T + K+ AEL E+ +LQ +
Sbjct: 1166 -----EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 1421 LHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSC 1480
L + ++ ++ ++ + +++L + R + D E++
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE-DQFSEIK--------------- 1264
Query: 1481 VPDSSSLSSLGDSSFYRALLE-QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRK 1539
D + D + +A L+ Q G++S V+E +E+L +
Sbjct: 1265 AKDEQQTQLIHDLNMQKARLQTQNGELSH-------------RVEE-------KESLISQ 1304
Query: 1540 ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR 1599
T S A Q LE+L+ +ME + KN + L S R + D LR
Sbjct: 1305 LTKSKQA------------LTQQLEELKRQMEEETKAKNA----MAHALQSSRHDCDLLR 1348
Query: 1600 KQYLSENE-----------------QWQQKLTSVTLEMESKLAAEKKQTEQLSLELE--- 1639
+QY E E QW+ K + ++ +L KK+ Q E E
Sbjct: 1349 EQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENT 1408
Query: 1640 -VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDA 1698
A + L+ + + L G + ED ++ D+ + HT+ T + + ++ A
Sbjct: 1409 ETANSKCASLEKTKQRLQG-EVEDLMR------DLERSHTACATLDKKQRNFDKVL---A 1458
Query: 1699 QQDLNLDIEKITETGAVKPTGECSGEQSPDTN-YEPPGEDKTQGSSECISELSFSGPNAL 1757
+ LD + A K + S E N YE E + +L
Sbjct: 1459 EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE-----------EVVDQLE------T 1501
Query: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817
+ + QE+I +L ++ ET + +++ L ++E++ L +E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQ---ELLQRVETSEGLNSDLEMHA 1874
++ +EL ++ EL ++ + E++E + Q E LQ V +E + + +
Sbjct: 1562 IL---RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRL 1618
Query: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC 1934
K D+ + ++ S ++ + +R+ + ++ L+L+ L
Sbjct: 1619 KKKMEGDLNEMEIQLGHSNRQ----MAETQKHLRTVQGQLKDSQLHLDDAL--------- 1665
Query: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL--E 1992
+ NE+ L+E+L++V L EL+ M AL+Q + QEL
Sbjct: 1666 --RSNED-------LKEQLAIVERRNGLLLEELEEMK---VALEQTERTRRLSEQELLDA 1713
Query: 1993 SHQSECLHCIQVAEAEVKEKTEL-LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051
S + + LH + K+K E + ++V +++ + +EK + D+ ++
Sbjct: 1714 SDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEEL 1773
Query: 2052 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
+ ++ A L + K+ L + + LQ RL E++ L K ++K E +R +
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ----IQKLENRVRELENE 1829
Query: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
+V Q +RG E L+ E+K + + +E + L+D V+ L+ +++ + E
Sbjct: 1830 LDVEQ-KRGAEALK-GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAE 1887
Query: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
A + ++ ++EE A + E + LR++ ++ Q E+
Sbjct: 1888 EAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 91.7 bits (226), Expect = 1e-17
Identities = 127/598 (21%), Positives = 243/598 (40%), Gaps = 118/598 (19%)
Query: 2401 LQKEQERISELEIINSSFE---------------------NILQEKEQEKVQMKEKSSTA 2439
L K E E+ + FE ++LQEK ++Q++ ++
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 2440 ME-------------MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
M+ +L+ ++KEL ER+ AK++NL + L+ + L
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 2487 QGLDEAKNNYIVLQSSVNGLIQE---VEDGKQKLEKKDEEISRLKNQIQDQEQ------- 2536
L + + ++ V L +E +E+ KL K+ + + Q D Q
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 2537 ----LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
+ +KL Q + + EQ +LR +LE+ + L+ Q+++ L++ +
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLR---ADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE---------- 2642
+E +L+ + + K++ + Q+++ E+ + EL+EE+ E
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 2643 KNRLAGELQLLLE---------------------EIKSSKDQLKELTLENSELKKSLDCM 2681
++ LA EL+ + E E + + L+E TL++ +L
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 2682 HKDQVEKEG-----------KVREEIAEYQLRLH------EAEKKHQALLLDTNKQYEVE 2724
D V + G K+ +E +E ++ + EA K ++ + T + E +
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ 1259
Query: 2725 IQTYREK----------LTSKEECLSSQKLEIDLLKSSKE----ELNNSLKATTQILEEL 2770
+ K L ++ L +Q E+ KE +L S +A TQ LEEL
Sbjct: 1260 FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL 1319
Query: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGT 2830
K+ + K N + + ++ LL + ++ +E K LQ+ LS +A E + T
Sbjct: 1320 KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALS--KANSEVAQWRT 1377
Query: 2831 VMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
+T + T E++E K+ L ++ +EA+E + S S LEK K+ L+ +V L
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS---LEKTKQRLQGEVEDL 1432
Score = 89.0 bits (219), Expect = 7e-17
Identities = 135/672 (20%), Positives = 279/672 (41%), Gaps = 122/672 (18%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGT 63
+W+ T A+Q+ +ELE KL + Q+ + ++ A+L+K KQ+++ E +
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED-- 1431
Query: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
L R+ +R C +L+K Q NF K + + +Q+L ++
Sbjct: 1432 -LMRDLERSHTACATLDK-------------KQRNFD--------KVLAEWKQKLDESQA 1469
Query: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
ELE +Q+ ++S L + + YE++ ++ E K L+
Sbjct: 1470 ELEAAQKESRSLSTEL------------------FKMRNAYEEVVDQLETLRRENKNLQE 1511
Query: 184 EVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
E+ L Q + + L +A + + + ++ V + E + H S +R
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI----LRVQL 1567
Query: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL 301
S E + +I + NS + L +++++N LR K
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK-------- 1619
Query: 302 QGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE 361
K+M+G +N E+++QL + ++ E +K L + +L + D A L+
Sbjct: 1620 ----KKMEGDLN---EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 362 QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL 421
++L + + E + +LEQ E+ + E
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQ--TERTRRLSE----------------------- 1707
Query: 422 TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM 481
QEL A + +L ++ L + K++LE ++ + + ++ E + Q S+ E + ++++
Sbjct: 1708 -QELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEV---ENSIQESRNAEEKAKKAI 1763
Query: 482 EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQ---NFAEEMKAKNTSQETMLR 538
+ LK + A HLE KN++Q + Q + AE++ K ++ ++
Sbjct: 1764 TDAAMMAEELKKEQDTSA----HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ--IQ 1817
Query: 539 DLQEKINQQENSLTLEKLKLAVA---DLEKQRDCSQDLLKKREHH--IEQLNDKLSKTEK 593
L+ ++ + EN L +E+ + A A + +R + + E H I +L D + K +
Sbjct: 1818 KLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQA 1877
Query: 594 ESKALLSALELKKKEYEELKEEKT--LFSCWKSENEKLLTQMESEKENLQSKINHLETCL 651
+ K+ K++ EE +E+ L C + ++E L + + +S++N L
Sbjct: 1878 KVKSY-------KRQAEEAEEQANTQLSRCRRVQHE--LEEAAERADIAESQVNKLRA-- 1926
Query: 652 KTQQIKSHEYNE 663
K++ + S + E
Sbjct: 1927 KSRDVGSQKMEE 1938
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 187 bits (474), Expect = 2e-46
Identities = 262/1157 (22%), Positives = 505/1157 (43%), Gaps = 142/1157 (12%)
Query: 1812 HLQEVQLMTKIEACI---ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNS 1868
H ++L KI+ + E EK + +K+E ++L +EL +++ T +
Sbjct: 827 HWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKN 886
Query: 1869 DLEMHADKSSR-----EDIGDNVAKVNDSWK-------ERFLDVENELSRIRSEKASIEH 1916
DL++ S E+ D + K + ER D E + + ++K +E
Sbjct: 887 DLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLED 946
Query: 1917 EALYLEADLE-------VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLR----- 1964
E L+ D++ V+ EK E +N + + L+E ++ +T E+ L+
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 1965 --GELDTMSKKTTALDQLSEKMKEKTQELES--HQSECLHC-----IQVAEAEVKEKTEL 2015
+L K +L++ K++++ ++LES Q + L + E ++K E
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Query: 2016 LQTLSSD---VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072
+ L +D + E LK K +LQS +D Q L L + + +I +L E L +E
Sbjct: 1067 ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGL---QFQKKIKELQARIEELEEEI 1123
Query: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
E+ +A ++++ ++ + ++ LE L E+ E A ++STQ E+++ +R E L++R + +E
Sbjct: 1124 EAERATRAKTEKQRSDYARELE-ELSERLEEAGGVTSTQIELNK-KREAEFLKLRRDLEE 1181
Query: 2133 KKQLHIAEKLKERERENDS---LKDKVENLERELQMSEENQ---ELVILDAENSKAEVET 2186
H A R++ DS L ++++NL+R Q E+ + +L I D +S V
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241
Query: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
K +E++ R+L E L R + E + + + E Q S L LEEKE
Sbjct: 1242 SKANLEKICRTL---EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 2247 EIQI---KEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
Q+ K+ E L+ QL+E N+A AL + + L EEE + + +
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 2304 EKLRARLEAD-----EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
++ ++ ++ K + +Q+ +E E L R+++ E ++E N + A+LE
Sbjct: 1359 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE--AVNAKCASLE 1416
Query: 2359 --AENSKGEVETLKAKIE-------GMTQSLRGLELDVVTIRSEKENLTNELQ---KEQE 2406
+ +GEVE L +E + + R + + +++ E EL+ KE
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 2407 RIS-ELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
+S EL + +++E L + E K + K ++ + Q+ E + + L ++ +
Sbjct: 1477 SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE-QIAENGKTIHELEKSRKQIE 1535
Query: 2466 AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS 2525
++ ++ L LE+A+ +EAK I L+ L Q + +K+ +KDEEI
Sbjct: 1536 LEKADIQ-----LALEEAEAALEHEEAKILRIQLE-----LTQVKSEIDRKIAEKDEEIE 1585
Query: 2526 RLKNQIQD-----QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE-------QKIQVLQ 2573
+LK Q Q L +++ +L K+ +L + ++L + ++ L+
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLR 1645
Query: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
S L+DT L + + E+ E +++ VE+ + E E R E ++
Sbjct: 1646 SVQGQLKDTQLHLDDALRGQEDLKE-----QLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
+L E+ + N +QLL + S K+L + +L+ ++ +D E K +
Sbjct: 1701 KLAEQELLDSNE---RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAK 1757
Query: 2694 EEIAEYQLRLHEAEKKH--QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751
+ I + + E +K+ A L K E ++ + +L E+ LK
Sbjct: 1758 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL---------ALKG 1808
Query: 2752 SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
K+++ ++ EL+ + N + V L+K R K+L + E
Sbjct: 1809 GKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRV-----------KELTYQSEE 1857
Query: 2812 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH 2871
+K + +LQ VD+L ++K K EE ++A+ +L K+
Sbjct: 1858 DRKNVLRLQ-------------DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHEL 1904
Query: 2872 EKLEKAKEMLETQVAHL 2888
E+ E+ ++ E+QV L
Sbjct: 1905 EEAEERADIAESQVNKL 1921
Score = 172 bits (437), Expect = 4e-42
Identities = 255/1196 (21%), Positives = 520/1196 (43%), Gaps = 142/1196 (11%)
Query: 1532 QEENLTRKETPSAPAKGVEELESLCEVYRQSLE-KLEEKMESQGIMKNKEIQELEQLLSS 1590
+E T+ E + AK E E L + ++ + +L+ + ES+ ++ +E +QL+ +
Sbjct: 855 EEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE--RCDQLIKA 912
Query: 1591 ERQELDCLRK--QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGL 1648
+ Q +++ + + E+ +LT+ ++E + + KK + L L L +
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 1649 DLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEK 1708
+ ++L TE+ + G +E+ T E+ + HQ A DL + +K
Sbjct: 973 ENKVKNL----TEE-LSGLDETI------AKLTREKKALQEAHQ----QALDDLQAEEDK 1017
Query: 1709 ITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQED 1768
+ K E +Q D E K + E ++ G L L + D
Sbjct: 1018 VNSLNKTKSKLE---QQVEDLESSLEQEKKLRVDLER-NKRKLEGDLKLAQESILDLEND 1073
Query: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIEL 1828
L R+K+ E +L +ED ++KEL +++ E ++ + +
Sbjct: 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 1133
Query: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAK 1888
EK + +E +LSE+LE E ++ +E+
Sbjct: 1134 EKQRSDYARELEELSERLE-------------EAGGVTSTQIEL---------------- 1164
Query: 1889 VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-LEKDNENKQKVIV 1947
N + FL + +L E+A+++HEA+ A L + + L + +N Q+V
Sbjct: 1165 -NKKREAEFLKLRRDL-----EEATLQHEAMV--AALRKKHADSVAELGEQIDNLQRVKQ 1216
Query: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA 2007
LE+E S E + L ++++SK L+++ ++++ E E IQ + +
Sbjct: 1217 KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE----IQRSLS 1272
Query: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
E+ + LQT + ++S L++K + + L + QA + EL+ Q+ + NK K
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESI---VSQLSRSKQAFTQQTEELKRQLEEENKAKNA 1329
Query: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV- 2126
L + +LQ+ + D + + E K E LS EV Q R E +
Sbjct: 1330 L---AHALQSSRHDCDLLREQYEEEQEG----KAELQRALSKANSEVAQWRTKYETDAIQ 1382
Query: 2127 RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVET 2186
R E E+ + +A++L++ E + +++ K +LE+ Q + E +++D E + +
Sbjct: 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
L + + L ++ ++E L ++E + +EL KL ++++ L++ E
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAE---LEASLKESRSLSTELFKLKNAYEEALDQLE-- 1497
Query: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
+K E+K L+ ++ +L E +A + + + E+S E+ ++ ++E+
Sbjct: 1498 --TVKRENKN----LEQEIADLTEQIAE---NGKTIHELEKSRKQIELEKADIQLALEEA 1548
Query: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE------HAALEAE 2360
A LE +E K L + +L + + D ++ + E+E + N + +AL+AE
Sbjct: 1549 EAALEHEEAKILRIQLELTQVKSEID---RKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605
Query: 2361 -NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
S+ E LK K+EG L +E+ + + L+ Q ++ + ++ +
Sbjct: 1606 VRSRNEAIRLKKKMEG---DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL---HLD 1659
Query: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL---SSQVE 2476
+ L+ +E K Q+ A +LQ +++EL A L + A K EQ L + +V+
Sbjct: 1660 DALRGQEDLKEQLAIVERRA-NLLQAEVEELR---ATLEQTERARKLAEQELLDSNERVQ 1715
Query: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
L + L+ + + + + LQS V ++ + ++K +K + + + +++ ++
Sbjct: 1716 LLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 2537 LVSKLSQVEGEHQLWKEQNLE--LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594
+ L ++ ++NLE +++L L++ Q L K Q ++ L++ + LE
Sbjct: 1776 TSAHLERM--------KKNLEQTVKDLQHRLDEAEQ-LALKGGKKQ--IQKLETRIRELE 1824
Query: 2595 NELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
ELE + V+ + K + EL + E + LQ+ L +LQ+
Sbjct: 1825 FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQD--------LVDKLQV-- 1874
Query: 2655 EEIKSSKDQLKELTLE-NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709
++KS K Q +E + N+ L K H+ +E + R +IAE Q+ A+ +
Sbjct: 1875 -KVKSYKRQAEEADEQANAHLTKFRKAQHE---LEEAEERADIAESQVNKLRAKTR 1926
Score = 169 bits (427), Expect = 5e-41
Identities = 234/1054 (22%), Positives = 461/1054 (43%), Gaps = 140/1054 (13%)
Query: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
Q + NL L +E ++ ++ +E + ++V + +E++++L ++ +L + C
Sbjct: 893 QAESENL-LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE---DEC 948
Query: 1826 IELEKIVGELK-------KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDL----EMHA 1874
EL+K + +L+ KE K++ + +EL ET L + E H
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLT---EELSGLDETIAKLTREKKALQEAHQ 1005
Query: 1875 ----DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT 1930
D + ED +++ K +++ D+E+ L + + + +E LE DL++ Q
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
L LE D + L+E L E QL+ +++ ++T L Q +K+KE
Sbjct: 1066 SILDLENDKQQ-------LDERLKKKDFEYCQLQSKVE--DEQTLGL-QFQKKIKELQAR 1115
Query: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
+E + E AE + KTE S+ ++ L E+L+ ++ ++ T
Sbjct: 1116 IEELEEEI-----EAERATRAKTE------KQRSDYARELEELSERLE----EAGGVTST 1160
Query: 2051 KCEL----ENQIAQLNKEKELLVKESESLQARLSESDYEKL--------NVSKALEAALV 2098
+ EL E + +L ++ E + E++ A L + + + N+ + +
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 2099 EKGEFALR---LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
EK EF L LSS+ E V + + +EK+ +E + E+++ E + K +
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 2156 VENLERELQMSEENQELVILDAENSK----AEVETLKTQIEEMARSLKVFELDLVTLRSE 2211
++ EL E +E ++ SK + E LK Q+EE ++ L + R +
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD 1340
Query: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEE----KEQAEIQIKEESKTAVEMLQNQLKE 2267
+ L +Q +E+Q +EL + LS S + + E IQ EE + A + L +L++
Sbjct: 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400
Query: 2268 LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL---CVLQQL 2324
E V A+ ++ T+Q L +E+ L +E+ + A +KKQ VL +
Sbjct: 1401 SEEQVEAVNAKCASLEKTKQRLQGEVED---LMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 2325 K------ESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQ 2378
K ++E A L + R +L EL + E A + E K E + L+ +I +T+
Sbjct: 1458 KTKCEESQAELEASLKESR--SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515
Query: 2379 --------------SLRGLELDVVTIRSEKENLTNELQKEQERISELEI----INSSFEN 2420
S + +EL+ I+ E L+ E+ +I +++ + S +
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR 1575
Query: 2421 ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQ------NLSSQ 2474
+ EK++E Q+K +E +Q+ L A + + EA + K++ + Q
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALD------AEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Query: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
+ + A+ L+ L + Q ++ ++ ED K++L + + L+ ++
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV--- 1686
Query: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594
E+L + L Q E +L EQ L ++ +++Q+L ++N SL T + L++ L+
Sbjct: 1687 EELRATLEQTERARKL-AEQEL------LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 1739
Query: 2595 NELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLL 2654
+E+E D + EK K + E+ + +A L E + + +LQ L
Sbjct: 1740 SEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNLEQTVKDLQHRL 1798
Query: 2655 EE-----IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL------ 2703
+E +K K Q+++L EL+ L+ K E +R +Y+ R+
Sbjct: 1799 DEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLR----KYERRVKELTYQ 1854
Query: 2704 HEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
E ++K+ L D + +V++++Y+ + +E
Sbjct: 1855 SEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE 1888
Score = 147 bits (370), Expect = 2e-34
Identities = 214/1009 (21%), Positives = 416/1009 (41%), Gaps = 161/1009 (15%)
Query: 2030 KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV 2089
K L L+ + D A +T+ + + + E + +V+ ES+ + + +NV
Sbjct: 767 KAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFC-IQYNIRSFMNV 825
Query: 2090 SKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149
L K + L+ + T++E+ ++ +K + + E K+ + EKL +E
Sbjct: 826 KHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEK 885
Query: 2150 DSLKDKVENLERELQMSEENQELVIL-----------------DAENSKAEVETLKTQIE 2192
+ L+ +V+ L +EE + +I D E AE+ K ++E
Sbjct: 886 NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE 945
Query: 2193 EMARSLK--VFELDLVTLRSEK-----ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2245
+ LK + +L+L + EK EN K + E+ L E L+ K L+E Q
Sbjct: 946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ 1005
Query: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
+ + + V L +L + V + L+ +E+E +LR +E+
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQV--------------EDLESSLEQEKKLRVDLER 1051
Query: 2306 LRARLEAD-------------EKKQL-----------CVLQQLKESEHHADL-------- 2333
+ +LE D +K+QL C LQ E E L
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Query: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE---GMTQSLRGL----ELD 2386
L+ R+E LE E+E R + + + E+E L ++E G+T + L E +
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 1171
Query: 2387 VVTIRSEKENLTNE--------LQKEQERISELEIINSSFENILQEKEQEKVQMK----- 2433
+ +R + E T + +K + ++EL + + + Q+ E+EK + K
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231
Query: 2434 -----EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG 2488
E S + L+ + L ++++ E + L++Q L+ E +L +
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ---------------D 2533
L+E ++ L S Q+ E+ K++LE++++ + L + +Q +
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 1351
Query: 2534 QE---QLVSKLSQVEGEHQLWK--------EQNLELRNLTVELEQKIQVLQSKNASLQDT 2582
QE +L LS+ E W+ ++ EL +L Q++Q + + ++
Sbjct: 1352 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAK 1411
Query: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTA----KETELQREMHEMAQKTAELQEE 2638
L+ + + L+ E+E D M VE+ N + A K+ + + E K E Q E
Sbjct: 1412 CASLEKTKQRLQGEVE----DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467
Query: 2639 LSG---EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREE 2695
L E L+ EL L + + DQL+ + EN L++ + + +Q+ + GK E
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL-TEQIAENGKTIHE 1526
Query: 2696 I-----------AEYQLRLHEAE---KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741
+ A+ QL L EAE + +A +L + K+ K+E +
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQ 1586
Query: 2742 QKLEID-LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIK 2800
K +++ + L+ +++ + + KK + D + QL N +A +K L
Sbjct: 1587 LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRS 1646
Query: 2801 SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTK----E 2856
QL++ + L L+ ++ ++ +++ + + L E++EL+ TLE+ +
Sbjct: 1647 VQGQLKDTQLHLD---DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 2857 ADEYLDKYCSLLISHEK---LEKAKEMLETQVAHLCS--QQSKQDSRGS 2900
E LD + + H + L K+ LET + L S + + +D+R +
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNA 1752
Score = 140 bits (353), Expect = 2e-32
Identities = 239/1161 (20%), Positives = 481/1161 (41%), Gaps = 189/1161 (16%)
Query: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE-LDKLTSVKQQLENNL 453
EFQ+ + R++ F CIQ R ++ M + + L K ++++
Sbjct: 801 EFQKMVQRRESIF------CIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK 854
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK------SHSEQKAREVC---- 503
EEF+ + + S+ K EL + + +E N L+ S + A E C
Sbjct: 855 EEFQ----KTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLI 910
Query: 504 ----HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA 559
LEA++K + + + E+ AK E +L++ I + L+L
Sbjct: 911 KAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI---------DDLELT 961
Query: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLF 619
+A +EK++ +++ +K + L++ ++K +E KAL E ++ ++L+ E
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL---QEAHQQALDDLQAE---- 1014
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
E + + K L+ ++ LE+ L+ ++ + R LE D + I
Sbjct: 1015 -------EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 1067
Query: 680 RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+L N ++ + Y +LQ K E +Q + + K +L ++E+LE ++
Sbjct: 1068 LDLENDKQQLDERLKKKDFEYCQLQSKVE-DEQTLGLQFQK---KIKELQARIEELEEEI 1123
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLL--------------KSKDAS-LVTNEDHQRSL 784
+ ++ D E E L + L K ++A L D + +
Sbjct: 1124 EAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183
Query: 785 LAFDQQ-PAMHHSFANIIGEQG-----------SMPSERSECRLEAD-------QSPKNS 825
L + A+ A+ + E G + E+SE +LE D K+
Sbjct: 1184 LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK 1243
Query: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIK-------GEIEENLMKAEQM----- 873
A L+ +LE L + N ++Q+ EL K GE+ L + E +
Sbjct: 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 874 --HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ---AEIQ 928
Q+F +T + +L+E+ A +N +A AL++ + LL ++ E EQ AE+Q
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKA-KNALAH---ALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 929 E-LKKSNHLLED--SLKELQLLSETLSLE--KKEMSSIISLNKREIEELTQENGTLKEIN 983
L K+N + + E + T LE KK+++ + ++ ++E + + +L++
Sbjct: 1360 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Query: 984 ASLNQEKMNL---IQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS 1040
L E +L ++++ S A +D+++++ ++ ++K +CEE+
Sbjct: 1420 QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK-------TKCEES-------- 1464
Query: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM 1100
++LE L E SL EL +LK A+ +E L +L + N+NL
Sbjct: 1465 ---------QAELEASLKESRSL----STELFKLKNAY----EEALDQLETVKRENKNLE 1507
Query: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVM 1160
E+ + + + KS +++I K + +E L+ E K++
Sbjct: 1508 QEIADLTEQIAENGKTIHELEKS-----RKQIELEKADIQLALEEAEAALEHEE--AKIL 1560
Query: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD----SYNAQL---VQL 1213
+ + E ++SE I + E++ E Q Q +E + +LD S N + ++
Sbjct: 1561 RIQLELTQVKSE-IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Query: 1214 EAMLRNKELKLQESEKE-KECLQHELQTIRGDLETSNL---QDMQSQEISGLKDCEIDAE 1269
E L E++L + ++ E L+H L++++G L+ + L ++ QE D +
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKH-LRSVQGQLKDTQLHLDDALRGQE---------DLK 1669
Query: 1270 EKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECI 1329
E+ + Q + L+ +L+ T K+ E + E V L+ + I
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQT----ERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Query: 1330 TATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNS 1389
+K+ ++ +L +EV+ + D+ + + I + ++ + A L+
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 1390 YEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL 1449
T+ D + ++ AE L+L+ K Q ++ +++ EL+ ++ + +N
Sbjct: 1786 NLEQTVKDLQHRLDEAEQ----LALKGGKK----QIQKLETRIRELEFELEGEQKKNTES 1837
Query: 1450 STNLRNFQGDLVKEMQLGLEE 1470
LR ++ VKE+ EE
Sbjct: 1838 VKGLRKYE-RRVKELTYQSEE 1857
Score = 140 bits (353), Expect = 2e-32
Identities = 228/1133 (20%), Positives = 474/1133 (41%), Gaps = 161/1133 (14%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQKQKQKVEN 57
K +ELE +L L +EK Q Q+ + LEA +++ ++ E+
Sbjct: 870 KRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAED 929
Query: 58 EKTEGTNLKRENQRLMEICESLEK-------TKQKISHELQVKESQVNFQEGQLNSGKKQ 110
E+ L + ++L + C L+K T K+ E E++V +L+ +
Sbjct: 930 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
Query: 111 IEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK 170
I KL +E K + +++ Q+ + +N N + SK E E
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK---------------SKLEQQVED 1034
Query: 171 YNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSS 230
+E+ K+L +++ + K D+ Q S +++ L
Sbjct: 1035 LESSLEQEKKLRVDLERNKRKLEG-----------DLKLAQESILDLENDKQQLDERLK- 1082
Query: 231 NSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL 290
++DF + E + LQ K+ + +L+A+ +EL
Sbjct: 1083 -------KKDFEYCQLQSKVEDEQTLG-LQFQKK---------------IKELQARIEEL 1119
Query: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD-ELVRTTAQ 349
+I EK+ + +EL +LE+A + + LNK R+ E ++
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAG-GVTSTQIELNKKREAEFLKLRRD 1178
Query: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT 409
++A+ ++ A+ L+K D + ++QK+++++ EF+ E+ S ++
Sbjct: 1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Query: 410 LDQECIQMK---ARLTQELQQAKNMHNVLQAELDKLTSVKQQLE-------NNLEEFKQK 459
+ + ++ L +L +A+ + +Q L +LT+ K +L+ LEE +
Sbjct: 1239 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL-------EAELK-N 511
+ + ++ QA + EL+R +EE K N L +H+ Q +R C L E E K
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNAL-AHALQSSRHDCDLLREQYEEEQEGKAE 1357
Query: 512 IKQCLNQSQNFAEEMKAK---NTSQET-MLRDLQEKINQ--QENSLTLEKLKLAVADLEK 565
+++ L+++ + + + K + Q T L + ++K+ Q Q++ +E + A LEK
Sbjct: 1358 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Query: 566 QRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE--------LKEEKT 617
+ Q ++ +E+ N + +K+ + L K + EE LKE ++
Sbjct: 1418 TKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Query: 618 LFS-CWKSEN--EKLLTQMES---EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD 671
L + +K +N E+ L Q+E+ E +NL+ +I L + HE + + +E++
Sbjct: 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELE 1537
Query: 672 RENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
+ ++ + + L+ + ++ +L +++ + + + +EIE + +
Sbjct: 1538 KADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597
Query: 732 VED-LEHKLQLLSNEIMDKDRCYQDL--------HAEYESLRDL--LKSKDASLVTNEDH 780
++ L+ +++ + I K + DL HA ++ L L+S L + H
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL-QNRVDSLE--F 837
A Q + A + + +E E R +Q+ + + Q +DS E
Sbjct: 1658 LDD--ALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Query: 838 SLESQKQMNSDLQKQCE-ELVQIKGEIEE---NLMKAEQMHQSFVAETSQRISKL--QED 891
L +Q +K+ E +L+Q++ E+E+ + AE+ + + + + +L ++D
Sbjct: 1716 LLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 892 TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL 951
TSAH + + LE K+LQ D E EQ ++ KK LE ++EL+ E
Sbjct: 1776 TSAHLERMKKN---LEQTVKDLQHRLD--EAEQLALKGGKKQIQKLETRIRELEF--ELE 1828
Query: 952 SLEKKEMSSIISLNK--REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREK 1009
+KK S+ L K R ++ELT + ++E + + + + + + K
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQ-----------SEEDRKNVLRLQDLVDKLQVKVK 1877
Query: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
S +++ ++ L + + + E+ ++ A+ + +KL + TS
Sbjct: 1878 SYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTS 1930
Score = 139 bits (350), Expect = 4e-32
Identities = 219/1041 (21%), Positives = 435/1041 (41%), Gaps = 137/1041 (13%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + K ++LE + +LKK+ + L +E + KV+N E + L
Sbjct: 928 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD 987
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQ 116
+L ++L++ Q+ +LQ +E +VN Q L S +Q +KL
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 1047
Query: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS--GSKYEDLK------ 168
+L+R K +LE + AQ + + L N Q++ Y SK ED +
Sbjct: 1048 DLERNKRKLEGDLKLAQESILDLE--NDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF 1105
Query: 169 EKYNKEVEER-KRLEAEVKALQAKKASQTLPQATMNHRDI----ARHQASSSVFSWQQEK 223
+K KE++ R + LE E++A +A +A +T Q + R++ R + + V S Q E
Sbjct: 1106 QKKIKELQARIEELEEEIEAERATRA-KTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 224 TPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR-----STLQIG-----------KRDAN 267
++ +RRD + E V R S ++G K +
Sbjct: 1165 NKKR---EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221
Query: 268 SSFF-----DNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKF--QELQL 320
S F D SSS + + KA +++ + + +G +E++ +++ Q+ +L
Sbjct: 1222 KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL 1281
Query: 321 QLEKAKV--ELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA 378
Q E ++ +L EKE ++++ T Q ++ + + L L R +
Sbjct: 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC 1341
Query: 379 ESARCSLEQKIKEKEKEFQEELSR------QQRSFQTLD-----QECIQMKARLTQELQQ 427
+ R E++ +E + E Q LS+ Q R+ D +E + K +L Q LQ
Sbjct: 1342 DLLREQYEEE-QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400
Query: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
++ + A+ L KQ+L+ +E+ + RA A K+ + + E K +
Sbjct: 1401 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460
Query: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
++ E +E L EL +K ++ + E +K +N + E + DL E+I
Sbjct: 1461 CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI--A 1518
Query: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL--- 604
EN T+ +L+ + +E ++ Q L++ E +E K+ + + E + S ++
Sbjct: 1519 ENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA 1578
Query: 605 -KKKEYEELKE--EKTLFSCWKSENEKLLTQMES--EKENLQSKINHLETCLKTQQIKSH 659
K +E E+LK ++T+ + + + ++ ++ E+ K+ ++ +N +E L SH
Sbjct: 1579 EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL------SH 1632
Query: 660 EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH---QK 716
+ TL+ +R++ L + ++ +L+++ +++ Q
Sbjct: 1633 ANRQAAETLK--------HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV- 775
E+E +L +E E +L E++D + Q LH + SL K + L+
Sbjct: 1685 EVE-------ELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQ 1737
Query: 776 ---TNEDHQRSLLAFDQQPAMHHSFANIIGEQ------GSMPSERSECRL---------- 816
ED R +++ + A ++ E+ S ER + L
Sbjct: 1738 LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1797
Query: 817 --EADQ-----SPKNSAILQNRVDSLEFSLESQKQMNSD-------LQKQCEELVQIKGE 862
EA+Q K L+ R+ LEF LE +++ N++ +++ +EL E
Sbjct: 1798 LDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEE 1857
Query: 863 IEENLMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
+N+++ + + Q V ++ + E +AH + LE E+ + +
Sbjct: 1858 DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQ 1917
Query: 920 VETEQAEIQELKKSNHLLEDS 940
V +A+ ++ S ++ +S
Sbjct: 1918 VNKLRAKTRDFTSSRMVVHES 1938
Score = 134 bits (338), Expect = 1e-30
Identities = 230/1101 (20%), Positives = 465/1101 (42%), Gaps = 159/1101 (14%)
Query: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
EKEM +FQ+ + +L K++ + E E+ L E Q S E++
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906
Query: 365 KKLTEDLSCQRQNAESARCSLEQKIK------EKEKEFQEELSRQQRSFQTLDQECIQMK 418
+L + A+ LE KIK E E+E EL+ ++R L+ EC ++K
Sbjct: 907 DQLIK-----------AKFQLEAKIKEVTERAEDEEEINAELTAKKRK---LEDECSELK 952
Query: 419 ARLTQ-ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL 477
+ EL AK + A +K+ ++ ++L + L+E KL R ++A Q +
Sbjct: 953 KDIDDLELTLAK-VEKEKHATENKVKNLTEEL-SGLDETIAKLTREKKALQEAH------ 1004
Query: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
++++++++ E + + S ++ K++ LE ++++++ L Q + +++ E L
Sbjct: 1005 QQALDDLQAEEDKVNSLNKTKSK----LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060
Query: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
+ QE ++ DLE + + LKK++ QL K+ +
Sbjct: 1061 KLAQE----------------SILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQ 1104
Query: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
++ + EEL+EE +++ EK + E E L ++ TQ
Sbjct: 1105 FQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ--- 1161
Query: 658 SHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
+E++++ E L L+ +++ E A L++K S + ++
Sbjct: 1162 ----------IELNKKR-EAEFLKLRRDLEEATLQHEAMVAA---LRKKHADSVAELGEQ 1207
Query: 718 IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN 777
I+N+ +L + + + ++ LS+ + + +L +L D L N
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK---N 1264
Query: 778 EDHQRSLLAFDQQPAMHHSFANIIGEQ-------GSMPSERSECRLEADQSPKNSAILQN 830
E+ QRSL Q + + A + Q S S + + + K +N
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEEN 1324
Query: 831 RV-DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQ 889
+ ++L +L+S + L++Q EE + K E++ L KA +E +Q +K +
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN-------SEVAQWRTKYE 1377
Query: 890 EDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL--- 946
D + E L + LQ ++VE A+ L+K+ L+ +++L +
Sbjct: 1378 TDAIQRTEELEEAKKKLAQR---LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434
Query: 947 ----LSETLSLEKKEMSSIISLNKREIEELTQE-NGTLKEINASLNQEKMNLIQKSESFA 1001
L+ L +++ +++ K + EE E +LKE + SL+ E L + ++
Sbjct: 1435 RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-SRSLSTE---LFKLKNAYE 1490
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
+D+ E ++ + +QE L ++ E G +L + K + + + ++ L E
Sbjct: 1491 EALDQLE-TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE 1549
Query: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER----NQNLMLELETVQQALRSEMTDN 1117
+ E+ + ++ +++ + E K+A +E +N +ET+Q AL +E+
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV--- 1606
Query: 1118 QNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL-LQENEQLMKVMKTKHECQNLESEPIRN 1176
S++EA LK+ KM+ ++N++ +Q + + +T ++++ +
Sbjct: 1607 --RSRNEAIRLKK----------KMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 1177 SVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE--LKLQESE----KE 1230
+ ++ R Q + K Q+ + + +L A++ +L A L E KL E E E
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANL--LQAEVEELRATLEQTERARKLAEQELLDSNE 1712
Query: 1231 KECLQHELQT----IRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG-------PHEL 1279
+ L H T + LET +L +QS+ +D +AEEK EL
Sbjct: 1713 RVQLLHTQNTSLIHTKKKLET-DLMQLQSEVEDASRDAR-NAEEKAKKAITDAAMMAEEL 1770
Query: 1280 STSQNDNAH-------LQCSLQTTMNKLNELEKIC--------EILQAEKYELVTELNDS 1324
Q+ +AH L+ +++ ++L+E E++ + L+ EL EL
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE 1830
Query: 1325 R---SECITATRKMAEEVGKL 1342
+ +E + RK V +L
Sbjct: 1831 QKKNTESVKGLRKYERRVKEL 1851
Score = 127 bits (318), Expect = 2e-28
Identities = 240/1026 (23%), Positives = 434/1026 (42%), Gaps = 148/1026 (14%)
Query: 1546 AKGVEELESLCEVYRQSLEKL---EEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602
AK E ++L E ++Q+L+ L E+K+ S K+K Q++E L SS QE K+
Sbjct: 991 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE-----KKL 1045
Query: 1603 LSENEQWQQKLTS-VTLEMESKLAAE--KKQTEQLSLELEVARLQLQGLDLSSRSLLGID 1659
+ E+ ++KL + L ES L E K+Q ++ + + QLQ + LG+
Sbjct: 1046 RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS-KVEDEQTLGLQ 1104
Query: 1660 TEDAI---QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVK 1716
+ I Q R E + E T +T K D ++L E++ E G V
Sbjct: 1105 FQKKIKELQARIEELEEEIEAERATRAKTEKQR------SDYARELEELSERLEEAGGVT 1158
Query: 1717 PTG-ECSGEQSPD-TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQL 1774
T E + ++ + E+ T ++ L +++ + E I NLQ
Sbjct: 1159 STQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELG-----EQIDNLQR 1213
Query: 1775 RVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE 1834
++ E I+D +ES+ L+ E QL E+++ + E
Sbjct: 1214 VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSE 1273
Query: 1835 LKKENS-------DLSEKLEY--------------FSCDHQELLQRVETSEGLNSDLEMH 1873
L + S +LS +LE F+ +EL +++E + L H
Sbjct: 1274 LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA-H 1332
Query: 1874 ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS--IEHEALYLEADLEVVQTE 1931
A +SSR D D + + + +E +++ LS+ SE A ++E ++ E+ + +
Sbjct: 1333 ALQSSRHDC-DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1391
Query: 1932 KLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL 1991
K ++ +++++V + + + + + +L+GE++ + + L+ + +K +
Sbjct: 1392 KKLAQRLQDSEEQV-EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNF 1450
Query: 1992 ESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051
+ +E + ++AE++ + ++LS+++ +L ++L++++++++ L
Sbjct: 1451 DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510
Query: 2052 CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
+L QIA+ K L K + + + EK ++ ALE A E AL
Sbjct: 1511 ADLTEQIAENGKTIHELEKSRKQI-------ELEKADIQLALEEA-----EAALE----H 1554
Query: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
EE LR +E +V+ E D K IAEK +++E L+R Q + E +
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRK----IAEK-----------DEEIEQLKRNYQRTVETMQ 1599
Query: 2172 LVILDAE-NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE-- 2228
LDAE S+ E LK ++M L E+ L + K ++ QGQL +
Sbjct: 1600 SA-LDAEVRSRNEAIRLK---KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQ 1655
Query: 2229 --LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV-----AALCGDQEI 2281
LD L + L KEQ I + +LQ +++EL + A +QE+
Sbjct: 1656 LHLDDALRGQEDL---KEQLAI-----VERRANLLQAEVEELRATLEQTERARKLAEQEL 1707
Query: 2282 MKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL 2341
+ + E+ ++ H S+ + +LE D L QL+ A N
Sbjct: 1708 LDSNER-----VQLLHTQNTSLIHTKKKLETD-------LMQLQSEVEDA---SRDARNA 1752
Query: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT--- 2398
E + + A T+ AA+ AE K E +T A +E M ++L D+ E E L
Sbjct: 1753 EEKAKKAITD---AAMMAEELKKEQDT-SAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1808
Query: 2399 --NELQKEQERISELEIINSSFE-NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVA 2455
++QK + RI ELE FE Q+K E V+ K ++ L Q +E + V
Sbjct: 1809 GKKQIQKLETRIRELE-----FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Query: 2456 ALHNDQEACKAKEQNLSSQVE---------CLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
L + + + K ++ Q E + KAQ L+EA+ + +S VN L
Sbjct: 1864 RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ--HELEEAEERADIAESQVNKL 1921
Query: 2507 IQEVED 2512
+ D
Sbjct: 1922 RAKTRD 1927
Score = 123 bits (309), Expect = 2e-27
Identities = 242/1215 (19%), Positives = 486/1215 (40%), Gaps = 199/1215 (16%)
Query: 160 SGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSW 219
S +K ++L+EK V+E+ L+ +V+A S+ L A + + + +
Sbjct: 867 SEAKRKELEEKLVTLVQEKNDLQLQVQA-----ESENLLDAEERCDQLIKAK-------F 914
Query: 220 QQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
Q E ++ ++ E+E+ + L KR
Sbjct: 915 QLEAKIKEVTERAE--------------DEEEI---NAELTAKKR--------------- 942
Query: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ---LEKAKVELIEKEKVL 336
+L+ + EL+ I++LEL L EKE NK + L + L++ +L ++K L
Sbjct: 943 --KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000
Query: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396
+ + QA A E K+ L + S Q E SLEQ EK+
Sbjct: 1001 QEA----------HQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-----EKKL 1045
Query: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
+ +L R +R ++ +L QE ++L E D KQQL+ L++
Sbjct: 1046 RVDLERNKRK--------LEGDLKLAQE--------SILDLEND-----KQQLDERLKKK 1084
Query: 457 KQKLCRAEQAFQASQI-------KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
+ C+ + + Q K EL+ +EE+++E ++ + ++ EL
Sbjct: 1085 DFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAREL 1144
Query: 510 KNIKQCLNQSQNFAEEMKAKNTSQET----MLRDLQEKINQQENSLTLEKLKLA--VADL 563
+ + + L ++ N +E + RDL+E Q E + + K A VA+L
Sbjct: 1145 EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAEL 1204
Query: 564 EKQRD----CSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLF 619
+Q D Q L K++ +++D S E SK+ + ++ + ++L E +
Sbjct: 1205 GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK- 1263
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
E ++ L+++ ++K LQ++ L L+ ++ + + + E L ++
Sbjct: 1264 ---NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 1320
Query: 680 RN-------LHNVLDSKSVEVETQKLAYMELQQ-KAEFSDQKHQKEIENMCLKTSQLTGQ 731
L + L S + + + Y E Q+ KAE + E +T T
Sbjct: 1321 EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380
Query: 732 V---EDLEHKLQLLSNEIMDKDRCYQDLHAEYESL---RDLLKSKDASLVTNEDHQRSL- 784
+ E+LE + L+ + D + + ++A+ SL + L+ + L+ + + SL
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440
Query: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSL 839
A D++ +F ++ E E S+ LEA S L+N + L
Sbjct: 1441 AALDKK---QRNFDKVLAE-WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQL 1496
Query: 840 ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVV 899
E+ K+ N +L+++ +L + E + + + E+ + E + L+E +A ++
Sbjct: 1497 ETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEE 1556
Query: 900 AETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS 959
A+ L + ++ K+ + EI++LK++ + ++ + L E + +
Sbjct: 1557 AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ------RTVETMQSALDAEVRSRN 1610
Query: 960 SIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK 1019
I L K+ G L EI L+ Q +E+ K + + Q K
Sbjct: 1611 EAIRLKKK-------MEGDLNEIEIQLSHANR---QAAETL--------KHLRSVQGQLK 1652
Query: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
+L L ++ EDL ++ + + + L+ + E + LEQ + A
Sbjct: 1653 DTQLHL----DDALRGQEDLKEQLAIVERRANLLQAEVEEL-------RATLEQTERARK 1701
Query: 1080 KEHQEFL---TKLAFAEERNQNLM---LELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133
QE L ++ +N +L+ +LET L+SE+ D ++++
Sbjct: 1702 LAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARN---------- 1751
Query: 1134 TLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
+ K +K + D E+L K T + ++ + +VK+ + +
Sbjct: 1752 ----AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-LEQTVKDLQHRLD------- 1799
Query: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNKELKLQ-ESEKEKECLQHELQTIRGDLETSNLQD 1252
E ++++L Q+ +LE +R E +L+ E +K E ++ + R E + +
Sbjct: 1800 ---EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSE 1856
Query: 1253 MQSQEISGLKDCEIDAEEKYISGPHEL-STSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
+ + L+D + K S + + NAHL + ++L E E+ +I +
Sbjct: 1857 EDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL-TKFRKAQHELEEAEERADIAE 1915
Query: 1312 AEKYELVTELNDSRS 1326
++ +L + D S
Sbjct: 1916 SQVNKLRAKTRDFTS 1930
Score = 103 bits (256), Expect = 3e-21
Identities = 222/1111 (19%), Positives = 451/1111 (40%), Gaps = 155/1111 (13%)
Query: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890
++ L S E++K+M + EE + K E+ ++ K +++ + V + +QE
Sbjct: 836 KIKPLLKSAETEKEMAT----MKEEFQKTKDELAKSEAKRKELEEKLV-------TLVQE 884
Query: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVE--------TEQAEIQE-----LKKSNHLL 937
V AE+ + L+ +E+ QL+ K + TE+AE +E L L
Sbjct: 885 KNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKL 944
Query: 938 EDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKS 997
ED EL+ + L L ++ + +++ LT+E L E A L +EK L +
Sbjct: 945 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Query: 998 ESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS-KLECL 1056
+ + + E ++ L+ + K L Q+ E+ ++ E +K + E+N KLE
Sbjct: 1005 QQALDDLQAEEDKVNSLN----KTKSKLEQQVEDLESSLEQ-EKKLRVDLERNKRKLEGD 1059
Query: 1057 LNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN----------QNLMLELETV 1106
L + +N+ +QL E K+ E+ + E+ + L +E +
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119
Query: 1107 QQALRSEMTDNQNNSK----------------SEAGGLKQEIMTLKEEQN----KMQKEV 1146
++ + +E K EAGG+ + L +++ K+++++
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDL 1179
Query: 1147 NDLLQENEQLMKVMKTKHECQNLE-SEPIRNSVKERES-ERNQCNFKPQMDLEVKEISLD 1204
+ ++E ++ ++ KH E E I N + ++ E+ + FK ++++ S++
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK--LEIDDLSSSME 1237
Query: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQH---ELQTIRGDLETS------NLQDMQS 1255
S + LE + R E +L E+ + E +Q EL T + L+T L++ +S
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES 1297
Query: 1256 --QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE 1313
++S K E+ E + ++N AH +LQ++ + + L + E Q
Sbjct: 1298 IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH---ALQSSRHDCDLLREQYEEEQEG 1354
Query: 1314 KYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQP 1373
K EL L+ + SE K + + E+ +++ + ++D E+
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEEL----EEAKKKLAQRLQD------SEEQ 1404
Query: 1374 NEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS 1433
E A L+++ + L +++ + +L + + + +K
Sbjct: 1405 VEAVNAKCASLEKTK--QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 1434 ELQTYVDSLKAENLVLSTNLRNF---------QGDLVKEMQLGLEEGLVPSLSSSCVPDS 1484
E Q +++ E+ LST L Q + VK LE+ + L+ +
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQE-IADLTEQIAENG 1521
Query: 1485 SSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSA 1544
++ L + S + LE+ L E A+ + + + Q + E
Sbjct: 1522 KTIHEL-EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ----VKSEIDRK 1576
Query: 1545 PAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNK----------EIQELE-QLLSSERQ 1593
A+ EE+E L Y++++E ++ ++++ +N+ ++ E+E QL + RQ
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQ 1636
Query: 1594 ELDCLRKQYLSENEQWQQKLTSVTL--------EMESKLAAEKKQTEQLSLELEVARLQL 1645
+ L+ + Q Q K T + L +++ +LA +++ L E+E R L
Sbjct: 1637 AAETLKH---LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693
Query: 1646 QGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSET----TERTPKHDVHQICD--KDAQ 1699
+ + + + E + NE + HT T T++ + D+ Q+ +DA
Sbjct: 1694 EQTERARKL-----AEQELLDSNERVQLL--HTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 1700 QDLNLDIEKITE--TGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
+D EK + T A E EQ + E ++ Q + L + AL
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1806
Query: 1758 VPMDFLGNQEDIHNLQLRVKETSNE-------NLRLLHVIEDRDRKVESLLNEMKELDSK 1810
G ++ I L+ R++E E N + + +R+V+ L + +E D K
Sbjct: 1807 -----KGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEE-DRK 1860
Query: 1811 LHLQEVQLMTKIEACIELEKIVGELKKENSD 1841
L+ L+ K++ ++ K E E ++
Sbjct: 1861 NVLRLQDLVDKLQVKVKSYKRQAEEADEQAN 1891
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 186 bits (473), Expect = 2e-46
Identities = 227/1145 (19%), Positives = 521/1145 (45%), Gaps = 127/1145 (11%)
Query: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
++++ N++ ++T E + ++ + K+ +L+ E +L ++Q+ + +A
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-------QLQVQAEADAL 902
Query: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
+ E+ +L K L K++ E+ +R E E +N++L A K ED
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIK-------EVTERAEDEEEINAELT--AKKRKLEDECSE 953
Query: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
+ K D + VE E ++ ++ E L+ + + EK L++ ++
Sbjct: 954 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
+ E++++ +T + +L ++D L+ E+ K+ +LE + + +++A
Sbjct: 1014 LQMEEDKVNTLTKAKTKLEQQVDD-------LEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066
Query: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
+ E T + ++E LK K LQ +D QAL++ +L+ +I +L
Sbjct: 1067 Q----ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAI---QLQKKIKELQARI 1119
Query: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
E L +E E+ +A ++++ ++ ++S+ LE + E+ E A +S Q E+++ +R E +
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELE-EISERLEEAGGATSAQIEMNK-KREAEFQK 1177
Query: 2126 VRIEADEKKQLHIAEKLKERERENDS---LKDKVENLERELQMSEENQELVILDAENSKA 2182
+R + +E H A R++ DS L +++++L+R Q E+ + + ++ + +
Sbjct: 1178 MRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS 1237
Query: 2183 EVETL---KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSL 2239
+ET+ K E+M R+L E L +++++E + I E Q + L F
Sbjct: 1238 NMETVSKAKANFEKMCRTL---EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQ 1294
Query: 2240 LEEKEQAEIQI---KEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296
L+EK+ Q+ K+ +E L+ QL+E +A + L + + L EEE
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 2297 HQLR-----------NSIEKLRARLEAD--------EKKQLCVLQQLKESEHHADLLKGR 2337
+ + + + + R + E D E+ + + Q+L+++E H + + +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAK-------IEGMTQSLRGLELDVVTI 2390
+LE+ + + E ++ E S L K + Q + ++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 2391 RSEKENLTNELQK----EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
+ E +L+ EL K +E + LE + +N+ QE Q+ E E L+
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHE-LEKV 1533
Query: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL-----------QGLDEAKNN 2495
K+L+ + L E +A ++ ++ ++LE Q+ + LD+ K N
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRN 1593
Query: 2496 YI----VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-QEQLVSKLSQVEGEHQL 2550
++ +QS+++ I+ D + +K + +++ ++ Q+ Q L + +
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI 1653
Query: 2551 WKEQNLELRNL---TVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
K+ L L + +L++++ +++ + +Q +E L++S + E ++ + + +
Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713
Query: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK-- 2665
E+V + + T L +++L + +++ GE++ +++E ++++++ K
Sbjct: 1714 SERVQLLHTQNTSL-----------INTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762
Query: 2666 --ELTLENSELKKSLD-CMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE 2722
+ + ELKK D H ++++K + + + + QLRL EAE+ L L K+
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKK--NMEQTVKDLQLRLDEAEQ----LALKGGKKQI 1816
Query: 2723 VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782
+++ +L S+ E S QK ++ +K L+ + ++EL ++ K +
Sbjct: 1817 QKLEARVRELESEVE--SEQKHNVEAVK--------GLRKHERRVKELTYQTEEDRKNIL 1866
Query: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTT 2841
+L+ ++ Q K+K + ++ EE+ + + +LQ +E ++ + +++V++L
Sbjct: 1867 RLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRV 1926
Query: 2842 EIKEL 2846
+ +E+
Sbjct: 1927 KSREV 1931
Score = 166 bits (420), Expect = 3e-40
Identities = 249/1196 (20%), Positives = 497/1196 (41%), Gaps = 148/1196 (12%)
Query: 1536 LTRKETPSAPAKGVEELESLCEVYRQSLEK---LEEKMESQGIMKNK---EIQELEQLLS 1589
L ET A EE E E ++ K LEEKM + KN ++Q L+
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 1590 SERQELDCLRKQYLSENEQWQQKLTSVTL------EMESKLAAEKKQTE----QLSLELE 1639
+ D L K + Q + K+ VT E+ ++L A+K++ E +L +++
Sbjct: 904 DAEERCDQLIKTKI----QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGRNES-CDISKEHTSETTERTPKHDVHQICDKDA 1698
L L ++ + TE+ ++ E + + T E+ + HQ
Sbjct: 960 DLELTLAKVEKEKHA-----TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ----QT 1010
Query: 1699 QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALV 1758
DL ++ +K+ K E +Q D E K E ++ G L
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLE---QQVDDLEGSLEQEKKLCMDLER-AKRKLEGDLKLA 1066
Query: 1759 PMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQL 1818
+ + D L ++K+ E L IED L ++KEL +++ E ++
Sbjct: 1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Query: 1819 MTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS 1878
+ + + EK +L +E ++SE+LE E ++ +EM+ +
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLE-------------EAGGATSAQIEMNKKR-- 1171
Query: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-LEK 1937
+ E + R E+++++HEA A L + + L +
Sbjct: 1172 --------------------EAEFQKMRRDLEESTLQHEA--TAAALRKKHADSVAELGE 1209
Query: 1938 DNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1997
++ Q+V LE+E S + E N L ++T+SK +++ ++++ E+++ + E
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
I E+ + L T S + S L +K + + L + QA + EL+ Q
Sbjct: 1270 QQRLIN----ELSAQKARLHTESGEFSRQLDEKDAM---VSQLSRGKQAFTQQIEELKRQ 1322
Query: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
+ + K K L + +LQ+ + D + + EA K E +S EV Q
Sbjct: 1323 LEEETKAKSTL---AHALQSARHDCDLLREQYEEEQEA----KAELQRGMSKANSEVAQW 1375
Query: 2118 RRGIEKLRV-RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2176
R E + R E E+ + +A++L++ E +++ K +LE+ Q + E +++D
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435
Query: 2177 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
E S A L + + F+ L + + E +++ Q + L L
Sbjct: 1436 VERSNAACIALD-------KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKV 1488
Query: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296
K+ EE +K E+K LQ ++ +L E +A ++ ++ LD E+
Sbjct: 1489 KNAYEESLDHLETLKRENKN----LQQEISDLTEQIAEGGKHIHELEKVKKQLD---HEK 1541
Query: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN----- 2351
+L+ S+E+ A LE +E K L + +L + + D ++ + EL+ + N
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID---RKIAEKDEELDQLKRNHLRVV 1598
Query: 2352 -QEHAALEAE-NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS 2409
+ L+AE S+ + +K K+EG L +E+ + + L+ Q +
Sbjct: 1599 ESMQSTLDAEIRSRNDALRIKKKMEG---DLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655
Query: 2410 ELEI-INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
+ ++ ++ + Q+ +E++ M E+ + M+ E+ E A+L + K E
Sbjct: 1656 DTQLHLDDAIRG--QDDLKEQLAMVERRANLMQ------AEVEELRASLERTERGRKMAE 1707
Query: 2469 QNL---SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS 2525
Q L S +V+ L + L+ + + + +Q + ++QE + ++K +K + +
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767
Query: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
+ +++ ++ + L +++ K +++L + L++ Q L K Q ++
Sbjct: 1768 MMAEELKKEQDTSAHLERMK------KNMEQTVKDLQLRLDEAEQ-LALKGGKKQ--IQK 1818
Query: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
L++ + LE+E+E + + V+ + K + EL + E + LQ+
Sbjct: 1819 LEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD-------- 1870
Query: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701
L +LQ ++ K ++ +E + N L K H+ +E K R +IAE Q+
Sbjct: 1871 LVDKLQTKVKAYKRQAEEAEEQS--NVNLAKFRKLQHE---LEEAKERADIAESQV 1921
Score = 160 bits (406), Expect = 1e-38
Identities = 211/1001 (21%), Positives = 442/1001 (44%), Gaps = 115/1001 (11%)
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
EK+ N ++ +EEL+ ++R +L ++ T+ ++ L + + + E
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909
Query: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
+ + EA++KE TE + +EL K L+++ L+KD L LT ++E
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 2056 NQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVH 2115
+ + + L +E L +++ EK + +A + L + L +++V+
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQMEEDKVN 1022
Query: 2116 QLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2175
L + KL +++ + L++ ++ L+ LE +L++++E+ +
Sbjct: 1023 TLTKAKTKLEQQVD-------DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES----TM 1071
Query: 2176 DAENSKAEV-ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 2234
D EN K ++ E LK + EM+ NL +I+++Q +L K +
Sbjct: 1072 DTENDKQQLNEKLKKKEFEMS------------------NLQGKIEDEQALAIQLQKKIK 1113
Query: 2235 SFKSLLEEKEQAEIQIKEESKTAVEMLQNQL-KELNEAVAALCGDQEIMKATEQSLDPPI 2293
++ +EE E+ EI+ + S+ E ++ L +EL E E ++ + I
Sbjct: 1114 ELQARIEELEE-EIEAERASRAKAEKQRSDLSRELEEI-------SERLEEAGGATSAQI 1165
Query: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL---LKGRVENLERELEIART 2350
E + +K+R LE + L++ HAD L ++++L+R +
Sbjct: 1166 EMNKKREAEFQKMRRDLEESTLQHEATAAALRKK--HADSVAELGEQIDSLQRVKQKLEK 1223
Query: 2351 NQEHAALEAENSKGEVETL---KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
+ +E + +ET+ KA E M ++L ++ T E++ L NEL ++ R
Sbjct: 1224 EKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR 1283
Query: 2408 ISELEIINSSFENILQEKEQEKVQM---KEKSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
L + F L EK+ Q+ K+ + +E L+ QL+E + + L + ++
Sbjct: 1284 ---LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSA 1340
Query: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI 2524
+ L Q E + KA+L +G+ +A + ++ D Q+ E+ +E
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYE------TDAIQRTEELEEAK 1394
Query: 2525 SRLKNQIQDQEQLV----SKLSQVEGEHQLWKEQNLELRNLTVELEQK---IQVLQSKNA 2577
+L ++QD E+ V SK + +E Q + QN E+ +L +++E+ L K
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQ--RLQN-EVEDLMIDVERSNAACIALDKKQR 1451
Query: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637
+ L + Y+ + ELE ++ + S ++ K+ E + + ++ LQ+
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ 1511
Query: 2638 ELSGEKNRLA--GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK---- 2691
E+S ++A G+ LE++K K+L E SEL+ SL+ +EGK
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVK------KQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 2692 ----------VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC--- 2738
+ +IAE L + ++ H ++ + EI++ + L K++
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE----NERA--- 2791
L+ +++++ E +L+ T IL++ + D ++ + LK++ RA
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM 1685
Query: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ----KTGTVMDTKVDELTTEIKELK 2847
Q +++ L S ++ E +++ ++EL L A++ Q + ++++TK +L T+I +++
Sbjct: 1686 QAEVEELRASLERTERGRKMAEQEL--LDASERVQLLHTQNTSLINTK-KKLETDISQIQ 1742
Query: 2848 ETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
+E+ +EA +K + + + + + AHL
Sbjct: 1743 GEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Score = 147 bits (371), Expect = 2e-34
Identities = 211/1063 (19%), Positives = 438/1063 (41%), Gaps = 142/1063 (13%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + K ++LE + +LKK+ + L +E + KV+N E L
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQ 116
+L + ++L++ Q+ +LQ++E +VN Q L +Q +KL
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCM 1050
Query: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGS---KYEDLK----- 168
+L+R K +LE + AQ + + N Q++ L ++ + K ED +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDTE--NDKQQL-NEKLKKKEFEMSNLQGKIEDEQALAIQ 1107
Query: 169 -EKYNKEVEER-KRLEAEVKALQAKKASQTLPQATMNHRDIARH-QASSSVFSWQQEKTP 225
+K KE++ R + LE E++A +A +A +A D++R + S T
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRA-----KAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 226 SHLSSNSQRTP----IRRDFSASYFSGEQEVTPSR-----STLQIGKRDANSSFFDNSSS 276
+ + N +R +RRD S E R S ++G++ S
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQI--------DSL 1214
Query: 277 PHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336
+ +L+ + EL+ +IN+L ++ K + L+ QL + K + E+++++
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274
Query: 337 NKC--------------------RDELVRTTAQYDQASTKYTA-LEQKLKKLTEDLSCQR 375
N+ +D +V ++ QA T+ L+++L++ T+ S
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334
Query: 376 QNAESAR--CSLEQKIKEKEKEFQEELSR----------QQRSFQTLD-----QECIQMK 418
+SAR C L ++ E+E+E + EL R Q R+ D +E + K
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
+L Q LQ A+ + ++ L KQ+L+N +E+ + R+ A A K+
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454
Query: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
+ + E K++ ++ E +E L EL +K +S + E +K +N + + +
Sbjct: 1455 KVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEIS 1514
Query: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
DL E+I E + +L+ L+ ++ Q L++ E +E K+ + + E +
Sbjct: 1515 DLTEQI--AEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQV 1572
Query: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
S ++ K E +E ++ L +ES + L ++I L+ ++
Sbjct: 1573 KSEIDRKIAEKDEELDQL---------KRNHLRVVESMQSTLDAEIRSRNDALRIKKKME 1623
Query: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQ--KHQK 716
+ NE L + +RNL N ++ + +TQ ++ + + +Q ++
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRN---TQGILKDTQLHLDDAIRGQDDLKEQLAMVER 1680
Query: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT 776
M + +L +E E ++ E++D Q LH + SL + K + +
Sbjct: 1681 RANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDI-- 1738
Query: 777 NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLE 836
+ I GE + E +A ++ ++A++
Sbjct: 1739 ---------------------SQIQGEMEDIVQEARNAEEKAKKAITDAAMMAE------ 1771
Query: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM----HQSFVAETSQRISKLQEDT 892
L+ ++ ++ L++ + + Q +++ L +AEQ+ + + + R+ +L+ +
Sbjct: 1772 -ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEV 1830
Query: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
+ Q E + L E+ ++ L + E ++ I L+D + +LQ +
Sbjct: 1831 ESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILR-------LQDLVDKLQTKVKAYK 1883
Query: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
+ +E ++N + +L E KE A + + ++N ++
Sbjct: 1884 RQAEEAEEQSNVNLAKFRKLQHELEEAKE-RADIAESQVNKLR 1925
Score = 144 bits (364), Expect = 1e-33
Identities = 262/1197 (21%), Positives = 505/1197 (42%), Gaps = 170/1197 (14%)
Query: 513 KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
K+ N + F E+ K + E ++L+EK+ +TL + K DL+ Q D
Sbjct: 851 KEMANMKEEF-EKTKEELAKTEAKRKELEEKM------VTLMQEK---NDLQLQVQAEAD 900
Query: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632
L E D+L KT+ + +A + + + ++ EE+ E T ++ KL
Sbjct: 901 ALADAEERC----DQLIKTKIQLEAKIKEVTERAEDEEEINAELT------AKKRKL--- 947
Query: 633 MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVE 692
E E L+ I+ LE L + + H +V+ NL+ E+ LD +
Sbjct: 948 -EDECSELKKDIDDLELTLAKVEKEKHATENKVK-------NLTEEMAG----LDETIAK 995
Query: 693 VETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
+ +K A E Q+ Q + ++ + ++L QV+DLE L+ MD +R
Sbjct: 996 LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
+ L DL ++++++ T D Q+ ++ +N+ QG + E++
Sbjct: 1056 KRKLEG------DLKLAQESTMDTENDKQQ---LNEKLKKKEFEMSNL---QGKIEDEQA 1103
Query: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE- 871
A Q K LQ R++ LE +E+++ + +KQ +L + EI E L +A
Sbjct: 1104 ----LAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159
Query: 872 ------QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE-LQLLNDKVETEQ 924
+M++ AE + L+E T H+ T +AL K + + L +++++ Q
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEESTLQHE----ATAAALRKKHADSVAELGEQIDSLQ 1215
Query: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Q+L+K L+ + +L ET+S K + + ++ E+ + + +
Sbjct: 1216 RVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLIN 1275
Query: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044
L+ +K L +S F+ +DE++ +S+LS + K Q+ EE L ++ K
Sbjct: 1276 ELSAQKARLHTESGEFSRQLDEKDAMVSQLS----RGKQAFTQQIEE---LKRQLEEETK 1328
Query: 1045 AAQEKNSKLECLLNECTSLCENRKNELE---QLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
A L+ ++C L E + E E +L+ +K + E E
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL----QENEQLM 1157
ELE ++ L + D + + ++ + + +L++ + ++Q EV DL+ + N +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEA----VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACI 1444
Query: 1158 KVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL-DSYNAQLVQLEAM 1216
+ K + + +E + +E ++E + + K L + + ++Y L LE +
Sbjct: 1445 ALDKKQRNFDKVLAE-WKQKYEETQAEL-EASQKESRSLSTELFKVKNAYEESLDHLETL 1502
Query: 1217 LR-NKELKLQESEKEKECLQ-----HELQTIRGDL--ETSNLQ-DMQSQEIS-------- 1259
R NK L+ + S+ ++ + HEL+ ++ L E S LQ ++ E S
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562
Query: 1260 -----GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314
L + + + K EL + ++ + S+Q+T++ E+ + L+ +K
Sbjct: 1563 LRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDA--EIRSRNDALRIKK 1620
Query: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374
++ +LN+ + A R+ AE + L N IL D LH L + I G
Sbjct: 1621 -KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ--LH--LDDAIRG-------- 1667
Query: 1375 EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE---HKILHDQHCQMSSK 1431
+ + E L + ++ + AE++E SL+ K+ + S +
Sbjct: 1668 -----------QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASER 1716
Query: 1432 MSELQTYVDSLKAENLVLSTNLRNFQG---DLVKEMQLGLEEGLVPSLSSSCVPDSSSLS 1488
+ L T SL L T++ QG D+V+E + EE +++ + + + L
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR-NAEEKAKKAITDAAMM-AEELK 1774
Query: 1489 SLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKG 1548
D+S A LE+ + N+E V Q +DE +L+ +K+ A+
Sbjct: 1775 KEQDTS---AHLER-----MKKNMEQTVKDLQLRLDEAEQLALKG---GKKQIQKLEAR- 1822
Query: 1549 VEELESLCEVYR-------QSLEKLEEKMES---QGIMKNKEIQELEQLLSSERQELDCL 1598
V ELES E + + L K E +++ Q K I L+ L+ + ++
Sbjct: 1823 VRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Query: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655
++Q EQ ++V L KL E ++ ++ ++A Q+ L + SR +
Sbjct: 1883 KRQAEEAEEQ-----SNVNLAKFRKLQHELEEAKE---RADIAESQVNKLRVKSREV 1931
Score = 144 bits (364), Expect = 1e-33
Identities = 229/1143 (20%), Positives = 470/1143 (41%), Gaps = 164/1143 (14%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDS----------------- 43
M E+ KE L + K +ELE ++ L +EK Q Q+ +
Sbjct: 856 MKEEFEKTKEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIK 914
Query: 44 ----LEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEK-------TKQKISHELQV 92
LEA +++ ++ E+E+ L + ++L + C L+K T K+ E
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 93 KESQV-----------------------------------NFQEGQLNSGKKQIEKLEQE 117
E++V +E ++N+ K KLEQ+
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034
Query: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177
+ + LE+ ++ + + K+ S + + + L EK K+ E
Sbjct: 1035 VDDLEGSLEQEKKLCMDLERAKRKLEGDLKL----AQESTMDTENDKQQLNEKLKKKEFE 1090
Query: 178 RKRLEAEVKALQA------KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231
L+ +++ QA KK + + +I +AS + + EK S LS
Sbjct: 1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRA----KAEKQRSDLSRE 1146
Query: 232 SQRTPIRRDFSASYFSGEQEVTPSR-STLQIGKRDANSSFFDNSSSPHLLDQLKAQN-QE 289
+ R + + S + E+ R + Q +RD S + ++ L + A + E
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE 1206
Query: 290 LRNKINELE---LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346
L +I+ L+ +L+ + E+K ++N + KAK EK+ D+L
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANF---EKMCRTLEDQL--- 1260
Query: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
+ TK E++ ++L +LS Q+ + +++ EK+ +LSR +++
Sbjct: 1261 ----SEIKTK----EEEQQRLINELSAQKARLHTESGEFSRQLDEKD-AMVSQLSRGKQA 1311
Query: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
F TQ++++ L+ +L++ T K L + L+ + +
Sbjct: 1312 F--------------TQQIEE-------LKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKA-REVCHLEAELKNIKQCLNQSQNFAEE 525
++ Q + EL+R M + E ++ E A + LE K + Q L ++ E
Sbjct: 1351 YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 526 MKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
+ +K S E + LQ ++ ++ + +E+ A L+K++ +L + + E+
Sbjct: 1411 VNSKCASLEKTKQRLQNEV--EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQ 1468
Query: 586 DKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
+L ++KES++L + L K YEE L +TL K EN+ L ++ E +
Sbjct: 1469 AELEASQKESRSLSTELFKVKNAYEESLDHLETL----KRENKNLQQEISDLTEQIAEGG 1524
Query: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNV-LDSKSVEVETQKLAYMEL 703
H+ K ++ HE +E +LE +L E + + L+ V+ E + ++
Sbjct: 1525 KHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR----KI 1580
Query: 704 QQKAEFSDQ---KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL-HAE 759
+K E DQ H + +E+M S L ++ L++ D + L HA
Sbjct: 1581 AEKDEELDQLKRNHLRVVESM---QSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHAN 1637
Query: 760 YESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD 819
++ L ++ + + A Q + A + M +E E R +
Sbjct: 1638 RQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLE 1697
Query: 820 QSPKNSAILQNRVDSLEFSLESQKQMNSDL---QKQCE-ELVQIKGEIEENLMK---AEQ 872
++ + + + + ++ N+ L +K+ E ++ QI+GE+E+ + + AE+
Sbjct: 1698 RTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEE 1757
Query: 873 MHQSFVAETSQRISKL--QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930
+ + + + +L ++DTSAH + + +E K+LQL D E EQ ++
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKN---MEQTVKDLQLRLD--EAEQLALKGG 1812
Query: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990
KK LE ++EL+ SE S +K + ++ L K E +KE+ +++
Sbjct: 1813 KKQIQKLEARVRELE--SEVESEQKHNVEAVKGLRKHE--------RRVKELTYQTEEDR 1862
Query: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
N++ + + + + + K+ +++ +++ + L + + + E+ ++ A+ +
Sbjct: 1863 KNIL-RLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQV 1921
Query: 1051 SKL 1053
+KL
Sbjct: 1922 NKL 1924
Score = 118 bits (295), Expect = 1e-25
Identities = 240/1231 (19%), Positives = 500/1231 (40%), Gaps = 198/1231 (16%)
Query: 1106 VQQALRSEMTDNQN-NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKH 1164
++ L+S T+ + N K E K+E+ + ++ ++++++ L+QE L
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-------- 891
Query: 1165 ECQNLESEPIRNSVKERESERNQ-CNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK 1223
L+ + +++ + E +Q K Q++ ++KE++ + + + + E + ++L+
Sbjct: 892 ---QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 948
Query: 1224 LQESEKEKECLQHELQTIRGDLE---TSNLQDMQSQEISGLKD--CEIDAEEKYISGPHE 1278
+ SE +K+ EL + + E T N ++E++GL + ++ E+K + H+
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
+ LQ +K+N L K L+ + +L L + C+ R
Sbjct: 1009 QTLD---------DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR-- 1057
Query: 1339 VGKLLNEVKILND---DSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTL 1395
KL ++K+ + D+ +L E + EF E N Q + DE L
Sbjct: 1058 --KLEGDLKLAQESTMDTENDKQQLNEKLKKKEF-EMSNLQGKIE----DEQALAIQLQK 1110
Query: 1396 SDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455
KE+Q EL+E+ + ++ Q +S ++ E+ ++ +
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 1456 FQGDLVKEMQLGLEEGLVPSLSSSCV---PDSSSLSSLGD--SSFYRALLEQTGDMSLLS 1510
+ + K M+ LEE + +++ + S++ LG+ S R + + S L
Sbjct: 1171 REAEFQK-MRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELK 1229
Query: 1511 NLEGAVSANQCSVD------EVFCSSLQEE--------------------NLTRKETPSA 1544
+++N +V E C +L+++ R T S
Sbjct: 1230 MEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESG 1289
Query: 1545 P-AKGVEELESLC-------EVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELD 1596
++ ++E +++ + + Q +E+L+ ++E + K L L S R + D
Sbjct: 1290 EFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE----TKAKSTLAHALQSARHDCD 1345
Query: 1597 CLRKQYLSENE---QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQL-QGLDLSS 1652
LR+QY E E + Q+ ++ E+ + Q + ELE A+ +L Q L
Sbjct: 1346 LLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--- 1402
Query: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
D E+ ++ N C + E T++ +++V +DL +D+E
Sbjct: 1403 ------DAEEHVEAVNSKC-----ASLEKTKQRLQNEV---------EDLMIDVE----- 1437
Query: 1713 GAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772
+ C N++ + Q E +EL S
Sbjct: 1438 ---RSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS-------------------- 1474
Query: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
Q + S E ++ + E+ +E+L E K L ++ Q+ + ELEK+
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534
Query: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEG--LNSDLEMHADKSSREDIGDNVAKVN 1890
+L E S+L LE E +E EG L LE++ KS +I +A+ +
Sbjct: 1535 KQLDHEKSELQTSLE-------EAEASLEHEEGKILRIQLELNQVKS---EIDRKIAEKD 1584
Query: 1891 ---DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE-KLCLEKDNENKQKVI 1946
D K L V + + ++AL ++ +E E ++ L N + +
Sbjct: 1585 EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL 1644
Query: 1947 VCLEEELSVVTSER----NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
L ++ + + +RG+ D + ++ +++ + M+ + +EL +
Sbjct: 1645 RNLRNTQGILKDTQLHLDDAIRGQ-DDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062
++AE E+ + +E +Q L + + L+ TK +LE I+Q+
Sbjct: 1704 KMAEQELLDASERVQLLHTQNTSLIN---------------------TKKKLETDISQIQ 1742
Query: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
E E +V+E AR +E +K A+ A ++K + T + ++++ +E
Sbjct: 1743 GEMEDIVQE-----ARNAEEKAKKAITDAAMMAEELKKEQ------DTSAHLERMKKNME 1791
Query: 2123 KL--RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENS 2180
+ +++ DE +QL LK +++ L+ +V LE E++ +++ +
Sbjct: 1792 QTVKDLQLRLDEAEQL----ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKH 1847
Query: 2181 KAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS-ELDKLLSSFKSL 2239
+ V+ L Q EE +++ + + L+++ + +Q +E + Q + L K L
Sbjct: 1848 ERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL 1907
Query: 2240 LEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
E KE+A+I + +K V+ + K ++E
Sbjct: 1908 EEAKERADIAESQVNKLRVKSREVHTKVISE 1938
Score = 115 bits (287), Expect = 9e-25
Identities = 170/779 (21%), Positives = 338/779 (43%), Gaps = 153/779 (19%)
Query: 2205 LVTLRSEKE--NLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQ 2262
L + +EKE N+ ++ ++ + +L++ + + + LEEK +Q K + LQ
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTE----AKRKELEEKMVTLMQEKND-------LQ 892
Query: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Q++ +A+A E+ D I+ + QL I+++ R E +E+ +
Sbjct: 893 LQVQAEADALA----------DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA 942
Query: 2323 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382
+ ++ E LK +++L EL +A+ +E A E +V+ L ++ G+ +++
Sbjct: 943 KKRKLEDECSELKKDIDDL--ELTLAKVEKEKHATE-----NKVKNLTEEMAGLDETIAK 995
Query: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKE---KSSTA 2439
L + ++ + ++LQ E+++++ L + E + + E Q K+ A
Sbjct: 996 LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 2440 MEMLQTQLKELNERVAALHNDQ----EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
L+ LK E ND+ E K KE +S+ +E E+A +Q + K
Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE- 1114
Query: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-QEQLVSKLSQVEGEHQLWKEQ 2554
LQ+ + L +E+E + K +++ S L ++++ E+L + ++ K++
Sbjct: 1115 ---LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 2555 NLELRNLTVELEQKIQVLQSKNASLQ--------------DTLEVLQSSYKNLENELELT 2600
E + + +LE+ ++ A+L+ D+L+ ++ + ++EL++
Sbjct: 1172 EAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 2601 KMDKMSFVEKVNKMTA------------------KETELQREMHEMAQKTAELQEELSGE 2642
D S +E V+K A KE E QR ++E++ + A L E SGE
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTE-SGE 1290
Query: 2643 KNR-----------LAGELQLLLEEIKSSKDQLKELTLENSELKKSL-----DC-MHKDQ 2685
+R L+ Q ++I+ K QL+E T S L +L DC + ++Q
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 2686 VEKE-----------GKVREEIAEYQLR-----------LHEAEKKHQALLLDTNKQYE- 2722
E+E K E+A+++ + L EA+KK L D + E
Sbjct: 1351 YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 2723 -----VEIQTYREKLTSKEE------------CLSSQKLEIDLLK----------SSKEE 2755
++ +++L ++ E C++ K + + K ++ E
Sbjct: 1411 VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE 1470
Query: 2756 LNNSLKATTQILEELKKTK---MDNLKYVNQLKKENERAQGKMKLLI-------KSCKQL 2805
L S K + + EL K K ++L ++ LK+EN+ Q ++ L K +L
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 2806 EEEKEILQKELSQLQAAQEKQKTGTVMDT-KVDELTTEIKELKETLEEKTKEADEYLDK 2863
E+ K+ L E S+LQ + E+ + + K+ + E+ ++K ++ K E DE LD+
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQ 1589
Score = 67.0 bits (162), Expect = 3e-10
Identities = 67/329 (20%), Positives = 151/329 (45%), Gaps = 26/329 (7%)
Query: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE 2634
K+A + + ++ ++ + EL T+ + EK+ + ++ +LQ ++ A A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 2635 LQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE 2694
EE + + +L+ ++E+ + +E+ E + K+ L+ ++ ++++
Sbjct: 905 -AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-------DECSELKK 956
Query: 2695 EIAEYQLRLHEAEKKHQALLLDTNKQYE--VEIQTYREKLTSKEECL-SSQKLEIDLLKS 2751
+I + +L L + EK+ A E + KLT +++ L + + +D L+
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQM 1016
Query: 2752 SKEELNNSLKATTQI---LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE 2808
++++N KA T++ +++L+ + K L++ + +G +KL +S E +
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEND 1076
Query: 2809 KEILQK-------ELSQLQA-AQEKQKTGTVMDTKVDELTTEIKELKETLE----EKTKE 2856
K+ L + E+S LQ +++Q + K+ EL I+EL+E +E + K
Sbjct: 1077 KQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
+ D L E+LE+A Q+
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQI 1165
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 186 bits (472), Expect = 3e-46
Identities = 337/1672 (20%), Positives = 677/1672 (40%), Gaps = 222/1672 (13%)
Query: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361
E E+ C L+ E ++ E+ DS ++ A +++ + + E++ L ++ + +
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 1362 EDIPG--GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419
ED + E N Q +S ++NS +++ +E++ +E+ L LQ +
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 1420 ILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE--GLVPSLS 1477
D+ + +++ + ++A + N+ + Q +L++ + EE L+ +
Sbjct: 207 ATTDEKKETVTQLQNI------IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIE 260
Query: 1478 SSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLT 1537
+S + ++ L + L NL A++ ++ + + L ENL
Sbjct: 261 ASAKEHEAEINKLNE---------------LKENLVKQCEASEKNIQKKYECEL--ENL- 302
Query: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597
RK T +A + +C + Q +E+ + N++++ LE L +
Sbjct: 303 RKATSNA-----NQDNQICSILLQENTFVEQVV-------NEKVKHLEDTLKELESQHSI 350
Query: 1598 LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657
L+ + N + LEM+++ ++ E+ LE ++ L L + +
Sbjct: 351 LKDEVTYMNN------LKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK---EEQGCVI 401
Query: 1658 IDTEDAIQGRNES-CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVK 1716
+ + G N+ C ++H E +H +I + + + + EK+T ++
Sbjct: 402 EKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ-KEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 1717 PTGE-CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE--DIHNLQ 1773
E C Q E + +EL S + + Q+ D+H LQ
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 1774 LRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVG 1833
+++ E LL + ++L + +L+++ E ELE +
Sbjct: 521 QKLRTAFTEKDALLETV------------------NRLQGENEKLLSQQELVPELENTIK 562
Query: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
L+++N L +EL ++ S E+ D + K+ +S
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKIN---------------SLTEEKDDFINKLKNSH 607
Query: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
+E ++N + E E L LE +V QT ++ ++E +QKV
Sbjct: 608 EE----MDNFHKKCERE------ERLILELGKKVEQT----IQYNSELEQKV-------- 645
Query: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
N+L G L+ K+ DQ EK+ + + L + +V AEVK
Sbjct: 646 -------NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDK-------EVLSAEVKSLY 691
Query: 2014 ELLQTLSSDVSELLKD-KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072
E LSS+ +L +D + L +K + L+ I QL K+ +L+V+E
Sbjct: 692 EENNKLSSEKKQLSRDLEVFLSQKEDVI-------------LKEHITQLEKKLQLMVEEQ 738
Query: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
++L L +KL V L L E G S ++ V+ L+ E L E
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKC 798
Query: 2133 KKQLHIAEKLKERERENDSLKDK----VENLERELQMSEENQELVILDAENSKAEVETLK 2188
EK+ E E+E L+++ E L+ L+ E+ + L+ + E ++E E L+
Sbjct: 799 NLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQ 858
Query: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD----------KLLSSFKS 2238
+ + EM + + R E +NL Q++E S+ + K + K
Sbjct: 859 SDLLEMKNANE-------KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKP 911
Query: 2239 LLEEKE----QAEIQIKEESKTAVEMLQNQ----LKELNEAVAAL---CGDQE------- 2280
LLE+KE +AE+ + ++S ++N +KEL E + L C ++E
Sbjct: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
Query: 2281 -IMKATEQSLDPPIEEEHQLRNSIEKLRAR-----------LEADEKKQLCVLQQLKESE 2328
+ ++ LD +E ++ +E LR+ ++ E + +L+ K+SE
Sbjct: 972 LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
Query: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
D+ K R N E +E ++ L+ E + E L A+IE + + + LE+ ++
Sbjct: 1032 Q-LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL 1090
Query: 2389 TIRSEKENLTNELQKE----QERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
++ K + EL+ E +++I E + E + + ++EK Q+ +K+ +E+++
Sbjct: 1091 EVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL-QKTMQELELVK 1149
Query: 2445 TQLKE---LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
++ +N +A + K N ++++E LE E Q + + LQS
Sbjct: 1150 KDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Query: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKL-SQVEGEHQLWKEQNLELRN 2560
SV ++ KQ L K +E++ K D L + L ++E Q + ++L
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN--KMTAKE 2618
+T E + + L++ Q TL Q L+ E K ++ + + K+
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN 1329
Query: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEE----IKSSKDQLKELTLENSEL 2674
Q++ M+Q E ++ L +L++ L++ ++ + +L+ L E+ L
Sbjct: 1330 VLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL 1389
Query: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
+ + M ++ V KE ++RE++ Q + +H + Q EV ++R+++
Sbjct: 1390 LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRH 1449
Query: 2735 KE-------ECLSSQ--KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLK 2785
+ E L Q K+E L + E S ++ Q L+ L++ + +L ++
Sbjct: 1450 LQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT 1509
Query: 2786 KENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKE 2845
E +G +S + L++ L+ + E E T E E
Sbjct: 1510 VTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHA-------EFTKE--E 1560
Query: 2846 LKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
L + L TK AD ++ L + ++L++++ L Q ++ S
Sbjct: 1561 LVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKS 1612
Score = 183 bits (464), Expect = 3e-45
Identities = 369/1686 (21%), Positives = 696/1686 (41%), Gaps = 288/1686 (17%)
Query: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICES 78
I+ L +LD L EK + + Q SL+ K KQ+VE+ T+ G K Q + +
Sbjct: 71 IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE 130
Query: 79 LEKTKQKI-SHELQVKESQVNFQEGQLNSGKKQIEKLEQ---------ELKRCKSELERS 128
+E K ++ + + E + N Q+ + Q+E EQ +K+ + E+E+
Sbjct: 131 IENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI 190
Query: 129 QQAAQSADVSLN---PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
+ + + L T +K T + + S++ Y K + + ++
Sbjct: 191 RPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQH------YQKNINSLQEELLQL 244
Query: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
KA+ ++ + + Q + ++ H+A + + +E ++ + I++ +
Sbjct: 245 KAIHQEEVKELMCQIEASAKE---HEAEINKLNELKENLVKQCEASEKN--IQKKYECEL 299
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFF----DNSSSPHLLDQLK---AQNQELRNKI---N 295
+ + + + QI + F N HL D LK +Q+ L++++ N
Sbjct: 300 ENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMN 359
Query: 296 ELELRLQGHEKEMKGQ-VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS 354
L+L+L+ + +K + ++ ++L+ ++ + + E+ V+ K + EL Q+
Sbjct: 360 NLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
Query: 355 TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414
++ Q LK+ Q++ +E L KEK E+ + + L QE
Sbjct: 420 EQHNREVQSLKE-----QHQKEISELNETFLSDSEKEK-LTLMFEIQGLKEQCENLQQE- 472
Query: 415 IQMKARLTQELQQAKNMHNVLQAEL--------DKLTSVKQQLENNLEEFKQKLCRAEQA 466
K + + + +LQ EL + S+KQQ +++ E +QKL
Sbjct: 473 ---KQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKL------ 523
Query: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
+ + +++ L ++ ++ EN L S E V LE +KN+ Q +N +
Sbjct: 524 -RTAFTEKDALLETVNRLQGENEKLLSQQEL----VPELENTIKNL-----QEKNGVYLL 573
Query: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLND 586
+ ++TML++L+ KI NSLT EK D + K ++ E++++
Sbjct: 574 SL--SQRDTMLKELEGKI----NSLTEEK---------------DDFINKLKNSHEEMDN 612
Query: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
K E+E + + LEL K K E+T+ Q SE L+ K+N
Sbjct: 613 FHKKCEREERLI---LELGK------KVEQTI-------------QYNSE---LEQKVNE 647
Query: 647 LETCLKTQQIKSHEYNE--------RVRTLEMDRENLSVEIRNLH---NVLDSKSVEVET 695
L L+ + +K + N+ +++ L D+E LS E+++L+ N L S+ ++
Sbjct: 648 LTGGLE-ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
Query: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
+ L QK + ++H ++E +L VE+ ++ +LL NE + K
Sbjct: 707 DLEVF--LSQKEDVILKEHITQLE------KKLQLMVEEQDNLNKLLENEQVQKLFVKTQ 758
Query: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815
L Y L+++ S V+ + ++ ++ Q A+ S A I E+ ++ +R E
Sbjct: 759 L---YGFLKEM-----GSEVSEDSEEKDVVNVLQ--AVGESLAKINEEKCNLAFQRDEKV 808
Query: 816 LEADQSPK---NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
LE ++ K +++Q + L+ L +Q L+K+ EE+ K ++ +L++ +
Sbjct: 809 LELEKEIKCLQEESVVQ--CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
Query: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE-NKEKELQLL----NDKVETEQAEI 927
++ E + +++E V++T S E + EKE + N K EQ E+
Sbjct: 867 ANEKTRLENQNLLIQVEE--------VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKEL 918
Query: 928 QELKKSNHLLEDSL--------------KELQLLSETLSLEKKEMSSIIS-------LNK 966
++ + LL+DSL KEL+ E L E KE I+ K
Sbjct: 919 RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978
Query: 967 REIEELTQENGTLKEINASLNQEK-------MNLIQKSESFANYIDEREKSISEL----- 1014
+E++ +E T+KE SL EK +LIQ +ES+ N + E EK +L
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 1015 ---------SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC--TSL 1063
D +Q + LQ CE + EDL + + Q LE + E
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQ-CETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA 1097
Query: 1064 CENRKNELEQL-KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
+++ E E+L KE KEH + +L + + Q +L+ Q L D Q +
Sbjct: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
E L +E N+ N+ +++ EQ +K+ K K E E +++SV++ E
Sbjct: 1158 MNMEIADYE--RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE 1215
Query: 1183 SERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
+ N ++ QL + + +++E + LQ +++
Sbjct: 1216 EK----------------------NTKIKQLLVKTKKELADSKQAETDHLILQ---ASLK 1250
Query: 1243 GDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
G+LE S Q E+ ++ EI +E+ I + S Q+ Q +L ++
Sbjct: 1251 GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQH-----QRTLSAYQQRVTA 1301
Query: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
L++ C +AE+ + +E + + + ++ K +++ + H E++
Sbjct: 1302 LQEECRAAKAEQATVTSEFESYK---VRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLI 1358
Query: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQM------HFAELQEKFLSLQS 1416
D + + N ++++ L S EH TL ++ +M AEL+EK S+QS
Sbjct: 1359 DQLKIKLQDSQNNLQ-INVSELQTLQS-EHDTLLERHNKMLQETVSKEAELREKLCSIQS 1416
Query: 1417 EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSL 1476
E+ ++ +H Q V L ++N VL + R+ L +E + +E +L
Sbjct: 1417 ENMMMKSEHTQT----------VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVE-----TL 1461
Query: 1477 SSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL 1536
+ L L + R+ L NL + + L +
Sbjct: 1462 QQQLSKMEAQLFQLKNEPTTRS---PVSSQQSLKNLRERRNTD--------LPLLDMHTV 1510
Query: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKL----EEKMESQGIMKNKEIQELEQLLSSER 1592
TR+E E + S Y QSLE+L E K+E +EL Q LSS
Sbjct: 1511 TREEGEGMETTDTESVSS-ASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTT 1569
Query: 1593 QELDCL 1598
+ D L
Sbjct: 1570 KSADHL 1575
Score = 171 bits (432), Expect = 1e-41
Identities = 321/1561 (20%), Positives = 644/1561 (41%), Gaps = 288/1561 (18%)
Query: 309 KGQVNKFQELQLQL-EKAKVELIEKEKVLNKCR---------DELVRTTAQYDQASTKYT 358
K + KF + Q+ L +KAK E EK + + R D + T + D +
Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
Query: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECI 415
EQ+ L ++ +Q E + + KE E+ + +E+ + + +
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
+ KA L ++L++A N Q EL + + E+N+++ ++++ + F+ +
Sbjct: 147 EDKANLQKQLEEAMNT----QLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202
Query: 476 ELRRSMEEMKKEN-----NLLKSHSEQKAREVCHLEAEL--------KNIKQCLNQSQNF 522
+ + + KKE N+++++S+ + + L+ EL + +K+ + Q +
Sbjct: 203 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
Query: 523 AEEMKAK----NTSQETMLRDLQ--EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKK 576
A+E +A+ N +E +++ + EK Q++ LE L+ A ++ + LL++
Sbjct: 263 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQE 322
Query: 577 REHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESE 636
+ +N+K+ E K L S + K E + K + + + + + E
Sbjct: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKL---EMDAQHIKDEFFHE 379
Query: 637 KENLQSKINHLETCLKTQ-----QIKSH-------------EYNERVRTLEMDRENLSVE 678
+E+L+ KIN L + Q ++KS ++N V++L +E E
Sbjct: 380 REDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSL---KEQHQKE 436
Query: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHK 738
I L+ S S E +KL M F Q +++ EN+ + + E L
Sbjct: 437 ISELNETFLSDS---EKEKLTLM-------FEIQGLKEQCENLQQEKQEAILNYESLREI 486
Query: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFA 798
+++L E+ + + E+ES+ K + AS V +E Q+ AF ++ A+ +
Sbjct: 487 MEILQTELGESAG---KISQEFESM----KQQQASDV-HELQQKLRTAFTEKDALLETVN 538
Query: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
+ GE + S++ E E + + KN LQ + SL + M +L+ + L +
Sbjct: 539 RLQGENEKLLSQQ-ELVPELENTIKN---LQEKNGVYLLSLSQRDTMLKELEGKINSLTE 594
Query: 859 IKGEIEENLMKAEQMHQSF----------VAETSQRISKLQEDTSAHQNVVAETLSALEN 908
K + L + + +F + E +++ + + S + V E LE
Sbjct: 595 EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
Query: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSII------ 962
KE + K+E +++ L + +L +K L + LS EKK++S +
Sbjct: 655 TLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714
Query: 963 -------------------------SLNK----REIEEL---TQENGTLKEIN------- 983
+LNK ++++L TQ G LKE+
Sbjct: 715 KEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 774
Query: 984 ----------------ASLNQEKMNLIQKSESFANYIDEREKSISE-----------LSD 1016
A +N+EK NL + + +++ K + E L
Sbjct: 775 EEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLR 834
Query: 1017 QYKQEKLILLQRCEETGNAYEDLSQ---KYKAAQEK----NSKLECLLNECTSLCENRKN 1069
Y+QEK++L + EE + E L + K A EK N L + E + C K+
Sbjct: 835 DYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCS--KS 892
Query: 1070 ELEQLKE-AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGL 1128
E+ KE F KEH+ L E R++ EL ++ +L ++ +N+ S L
Sbjct: 893 EIHNEKEKCFIKEHENLKPLLEQKELRDRR--AELILLKDSL-AKSPSVKNDPLSSVKEL 949
Query: 1129 KQEIMTLKEEQNKMQKEVNDL-------LQENEQLMKVMKT-KHECQNLESE------PI 1174
+++I L++E + ++++N + +E + K +T K E ++L SE +
Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009
Query: 1175 RNSVKERESERN-QCNFKPQMD-LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKE 1232
R+ ++ ES +N ++ Q + L+V++ +++ ++ L LRN L+ + + E
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069
Query: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE-KYISGPHELSTSQNDNAHLQC 1291
L ++T++ + + +Q ++ Q + D E++AE+ + E +T+ N+ LQ
Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129
Query: 1292 SL----------------------QTTM-----------------------NKLNELEKI 1306
L QTT+ NK+ +LE+
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Query: 1307 CEILQAEKYELVTELNDSRS------ECITATRKMAEEVGKLLNEVKILNDDSGLLHGEL 1360
+I + ++ L E+ +S E T +++ + K L + K D +L L
Sbjct: 1190 IKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1249
Query: 1361 VEDIPGGEFGEQPNEQHPVSLAPL--DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
++ E +Q E + + LA + ++ +EHL S ++ Q + Q++ +LQ E
Sbjct: 1250 KGEL---EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEEC 1306
Query: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD---------LVKEMQLGLE 1469
+ + ++S+ + V ++ + S + +G L+ ++++ L+
Sbjct: 1307 RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
Query: 1470 EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS 1529
+ ++ + S L +L S + LLE+ M L+ VS + + E C
Sbjct: 1367 DS-----QNNLQINVSELQTL--QSEHDTLLERHNKM-----LQETVS-KEAELREKLC- 1412
Query: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLS 1589
S+Q EN+ K S + V +L S EV R S ++ + K ++ L+Q LS
Sbjct: 1413 SIQSENMMMK---SEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE---HRKTVETLQQQLS 1466
Query: 1590 SERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE-VARLQLQGL 1648
+L L+ + + + V+ + K E++ T+ L++ V R + +G+
Sbjct: 1467 KMEAQLFQLKNEPTTR--------SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM 1518
Query: 1649 D 1649
+
Sbjct: 1519 E 1519
Score = 166 bits (420), Expect = 3e-40
Identities = 247/1017 (24%), Positives = 464/1017 (45%), Gaps = 153/1017 (15%)
Query: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT-ELLQTLSSDVSELLKDKTHLQEKLQ 2038
L +K K + ELE E + V E T ++++ L+ + LL +K +++
Sbjct: 40 LIQKAKSRCTELEKEIEE------LRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCL 93
Query: 2039 SLEKDSQALSLTKCELENQIAQL-NKEKEL------LVKESESLQARL----SESDYEKL 2087
SL+K++ + K E+E+ + ++ + KEL VKE E+L+ L S+ +K
Sbjct: 94 SLKKENIKM---KQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKA 150
Query: 2088 NVSKALEAALVEKGEFALRLS----------STQEEVHQLRRGIEK----LRVRIEA--D 2131
N+ K LE A+ + E + +L QEE+ ++R G E+ L+ +++A D
Sbjct: 151 NLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTD 210
Query: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEENQELVILDAENSKAEVETLKTQ 2190
EKK+ + + E + + + +L+ E LQ+ +QE EV+ L Q
Sbjct: 211 EKKET-VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE-----------EVKELMCQ 258
Query: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS-----ELDKLLSSFKSLLEEKEQ 2245
IE S K E ++ L KENL KQ + + + EL+ L + + ++ +
Sbjct: 259 IE---ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQI 315
Query: 2246 AEIQIKEES------KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD---PPIEEE 2296
I ++E + V+ L++ LKEL + L + M + L+ I++E
Sbjct: 316 CSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDE 375
Query: 2297 --HQLRNSIEKLRARLEADEKKQLCVLQQLKES------------EHHADLLKGRVENLE 2342
H+ + K+ L A E +Q CV+++LK E H ++ E +
Sbjct: 376 FFHEREDLEFKINELLLAKE-EQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ 434
Query: 2343 REL-EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401
+E+ E+ T + E E++ LK + E + Q + L+ ++R E L EL
Sbjct: 435 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
Query: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
+ +IS+ FE++ Q++ + ++++K TA T+ L E V L +
Sbjct: 495 GESAGKISQ------EFESMKQQQASDVHELQQKLRTAF----TEKDALLETVNRLQGEN 544
Query: 2462 EACKAKEQ---NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE 2518
E ++++ L + ++ L+ + L L + L+ +N L +E +D KL+
Sbjct: 545 EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
Query: 2519 KKDEEISRLKNQIQDQEQLVSKL-SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA 2577
EE+ + + +E+L+ +L +VE Q E ++ LT LE + L+ K+
Sbjct: 605 NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE---ETLKEKDQ 661
Query: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHE-MAQKTAELQ 2636
+ Q LE L K L + E+ + S E+ NK+++++ +L R++ ++QK +
Sbjct: 662 NDQ-KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
Query: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKK------------------SL 2678
+E +L +LQL++EE +D L +L LEN +++K S
Sbjct: 721 KE---HITQLEKKLQLMVEE----QDNLNKL-LENEQVQKLFVKTQLYGFLKEMGSEVSE 772
Query: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN-KQYEVEIQTYREKLTSKEE 2737
D KD V V + + E +++E EK + A D + E EI+ +E+ + E
Sbjct: 773 DSEEKDVV----NVLQAVGESLAKINE-EKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
Query: 2738 CLSS----QKLEIDLLKSSKEELNNSLKATTQILEELK----KTKMDN------LKYVNQ 2783
L S + E LL+ EE+ + +A L E+K KT+++N ++ V+Q
Sbjct: 828 ELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887
Query: 2784 LKKENERAQGKMKLLIK---SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
++E K K IK + K L E+KE+ + + K+ +V + + +
Sbjct: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSV- 946
Query: 2841 TEIKELKETLEEKTKEADEYLDKYCSLLISHEK-LEKAKEMLETQVAHLCSQQSKQD 2896
E++E E LE++ KE +E ++K + + +K L+ +++ +T L S +S++D
Sbjct: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Score = 126 bits (317), Expect = 3e-28
Identities = 221/1184 (18%), Positives = 475/1184 (40%), Gaps = 169/1184 (14%)
Query: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESL 79
++ELEG+++ L +EK + + K K E +RE + ++E+ + +
Sbjct: 582 LKELEGKINSLTEEK----------DDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631
Query: 80 EKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE--RSQQAAQSADV 137
E+T Q S E +VN G L K+ ++ +Q+L++ +++ + SA+V
Sbjct: 632 EQTIQYNSE----LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687
Query: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE----ERKRLEAEVKALQAKKA 193
S Y +K K++ ++++E +++ + + Q +K
Sbjct: 688 K-----------------SLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKK 730
Query: 194 SQTLPQATMNHRDIARHQASSSVFSWQQ-----EKTPSHLSSNSQRTPIRRDFSASYFSG 248
Q + + N + ++ +F Q ++ S +S +S+ + A
Sbjct: 731 LQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA----- 785
Query: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
S +I + N +F + L ++K +E + EL+ L+ +E+E
Sbjct: 786 -----VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
Query: 309 KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE------- 361
+ +E+Q + E + +L+E + K R E Q ++ S + E
Sbjct: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
Query: 362 ------QKLKKLTEDLSCQRQNAE--SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
+ LK L E + + AE + SL + K + + + L++E
Sbjct: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPL-SSVKELEEKIENLEKE 959
Query: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
C + + ++ + A L + + +VK++LE+ E Q Q ++
Sbjct: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESY 1019
Query: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
+N L E +K++ L E+ + E ++++ + L S E + + N
Sbjct: 1020 KNLLL----EYEKQSEQLDVEKER----ANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 534 ETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH-----HIEQLNDKL 588
+ LQ E + + A+ D E + + Q K +EH +E+L +L
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQL 1131
Query: 589 SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE 648
K +K+ + + LEL KK+ ++ TL + ++ E+L+ ++ + N +KI LE
Sbjct: 1132 QKEKKQLQKTMQELELVKKD----AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE 708
+K Q+ K +E L EI +L + + + E + K+ + ++ K E
Sbjct: 1188 QEIKIQKQK--------------QETLQEEITSLQSSV--QQYEEKNTKIKQLLVKTKKE 1231
Query: 709 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
+D K Q E +++ L+ S L G++E + ++++ ++ ++ +E + + LK
Sbjct: 1232 LADSK-QAETDHLILQAS-LKGELEASQQQVEVYKIQL-------AEITSEKHKIHEHLK 1282
Query: 769 SKDASLVTNEDHQRSLLAFDQQ-PAMHHSFANIIGEQGSMPSE----------------- 810
+ + E HQR+L A+ Q+ A+ EQ ++ SE
Sbjct: 1283 T------SAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN 1336
Query: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQK---QMN-SDLQ--------------KQ 852
+S + E + + + L+ +D L+ L+ + Q+N S+LQ K
Sbjct: 1337 KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396
Query: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
+E V + E+ E L + + +E +Q +S+L +N + + L+ + ++
Sbjct: 1397 LQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
Query: 913 LQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
VET Q ++ +++ L++ +S SL+ L ++ +
Sbjct: 1457 ------TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
T+E G + + + + + ++S ++ E + + K L+Q+ T
Sbjct: 1511 TREEG--EGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSST 1568
Query: 1033 GNAYEDLSQKYKAAQEKNS----KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTK 1088
+ + L+ + + N+ +++ L +E L N++ E + K
Sbjct: 1569 TKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIF 1628
Query: 1089 LAFAEERNQ-----NLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
L ER + N ML+L ++ + + + + S + G
Sbjct: 1629 LKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
Score = 125 bits (314), Expect = 7e-28
Identities = 181/790 (22%), Positives = 327/790 (41%), Gaps = 144/790 (18%)
Query: 2153 KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
K K+E L +E + ++++++ + +K+ L+ +IEE+
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLI--QKAKSRCTELEKEIEELR----------------- 59
Query: 2213 ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAV 2272
+K + E G + + L +LL EK + E Q K ++M Q E+ ++V
Sbjct: 60 ---SKPVTEGTGDI--IKALTERLDALLLEKAETEQQCLSLKKENIKMKQ----EVEDSV 110
Query: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
+ GD K EQS ++E L+N + +R+ K SE A+
Sbjct: 111 TKM-GDAH--KELEQSHINYVKEIENLKNELMAVRS----------------KYSEDKAN 151
Query: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE----GMTQSLRGLELDVV 2388
L K E + +LE++ + NS+ V+ L+ +IE G + + L+ +
Sbjct: 152 LQKQLEEAMNTQLELSEQLKFQ-----NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 2389 TIRSEKENLTNELQKEQERISE--LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
EK+ +LQ E S+ + INS E +LQ K + ++KE +
Sbjct: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
Query: 2447 LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
E+N+ N + C+A E+N+ + EC ELE + N + N
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYEC-ELENLRKATSNANQDNQICSILLQENTF 325
Query: 2507 IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
+++V + K K L L ++E +H + K++ + NL ++LE
Sbjct: 326 VEQVVNEKVK-------------------HLEDTLKELESQHSILKDEVTYMNNLKLKLE 366
Query: 2567 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTA---------- 2616
Q ++ + ++ LE NEL L K ++ +EK+ A
Sbjct: 367 MDAQHIKDEFFHEREDLEFKI-------NELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
Query: 2617 ----KETELQREMHEMAQKTAELQE----ELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
+E + +E H+ ++ +EL E + EK L E+Q L E+ ++ + + +E
Sbjct: 420 EQHNREVQSLKEQHQ--KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI 477
Query: 2669 LENSELKKSLDCMHKDQVEKEGKVREE-----------IAEYQLRLHEAEKKHQALLLDT 2717
L L++ ++ + + E GK+ +E + E Q +L A + ALL
Sbjct: 478 LNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV 537
Query: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
N+ +Q EKL S++E + + I L+ SL +L+EL+ K+++
Sbjct: 538 NR-----LQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG-KINS 591
Query: 2778 LK-----YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832
L ++N+LK +E +M K C++ EE+ IL+ Q Q
Sbjct: 592 LTEEKDDFINKLKNSHE----EMDNFHKKCER--EERLILELGKKVEQTIQYNS------ 639
Query: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
EL ++ EL LEE KE D+ K L++ + L + KE+L +V L +
Sbjct: 640 -----ELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694
Query: 2893 SKQDSRGSPL 2902
+K S L
Sbjct: 695 NKLSSEKKQL 704
Score = 116 bits (290), Expect = 4e-25
Identities = 223/1070 (20%), Positives = 431/1070 (40%), Gaps = 150/1070 (14%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL----- 72
QK+ EL G L++ KEK Q +L+ L ++ + E E +L EN +L
Sbjct: 643 QKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK 702
Query: 73 -----MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK----KQIEKLEQE------ 117
+E+ S ++ H Q+++ E Q N K +Q++KL +
Sbjct: 703 QLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF 762
Query: 118 LKRCKSELERSQQ-----------AAQSADVSLNPCNTP----QKIFTTP--LTPSQYYS 160
LK SE+ + A ++ CN +K+ + Q S
Sbjct: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
Query: 161 GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220
+ E+LK +E+ L E++ +Q++K + M + + + ++
Sbjct: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
Query: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
+E +S ++ I + + + + P ++ R A +S L
Sbjct: 883 EE-----VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDS----LA 933
Query: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
+N L + + ELE +++ EKE K + K +++L KAK EL K +
Sbjct: 934 KSPSVKNDPL-SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK 992
Query: 341 DELVRTTAQYDQAST----------KYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
+EL ++ DQ S Y L + +K +E L +++ A + +E +
Sbjct: 993 EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR 1052
Query: 391 E-KEKEFQEELSRQQRSFQTLDQECIQMKARLTQ----ELQQAKNMHNVLQAELDK-LTS 444
+ + Q E E +Q A+L + E+Q+AK M +DK L +
Sbjct: 1053 QLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM-------VDKELEA 1105
Query: 445 VKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA---RE 501
K Q E ++E + E+ Q ++ +L+++M+E++ L+K ++Q E
Sbjct: 1106 EKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELE----LVKKDAQQTTLMNME 1161
Query: 502 VCHLEAELKNIKQCL----NQSQNFAEEMKAKNTSQETM---LRDLQEKINQQENSLT-- 552
+ E +K + Q L N+ ++ +E+K + QET+ + LQ + Q E T
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI 1221
Query: 553 ---LEKLKLAVADLEKQRDCSQDL--------LKKREHHIE----QLNDKLSKTEKESKA 597
L K K +AD KQ + + L+ + +E QL + S+ K +
Sbjct: 1222 KQLLVKTKKELAD-SKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEH 1280
Query: 598 LLSALELKKKEYEELKEEKTLFS----CWKSENEKLLTQMESEKENLQSKINHLETCLKT 653
L ++ E ++ ++ T K+E + ++ ES K + + + + +
Sbjct: 1281 LKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS 1340
Query: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET------------QKLAYM 701
Q ER LEM + L +++++ N L E++T K+
Sbjct: 1341 QAETEGAKQER-EHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQE 1399
Query: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE-Y 760
+ ++AE ++ + ENM +K S+ T V L + ++L N D+ R Q+ H +
Sbjct: 1400 TVSKEAELREKLCSIQSENMMMK-SEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV 1458
Query: 761 ESLRDLLKSKDASL--VTNEDHQRSLLAFDQQPAMHHSFANI---IGEQGSMPSERSECR 815
E+L+ L +A L + NE RS ++ Q N + + ++ E E
Sbjct: 1459 ETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM 1518
Query: 816 LEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQ 875
D +SA SLE L S + + L+ K E+ + L
Sbjct: 1519 ETTDTESVSSA--STYTQSLEQLLNSPE---TKLEPPLWHAEFTKEELVQKL-------- 1565
Query: 876 SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
S +++ ++ L +T A ++ E + L+++ + L+ N + E A ++ LK N
Sbjct: 1566 SSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLE-RNQEREKSAANLEYLK--NV 1622
Query: 936 LLE--------DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
LL+ + + L +++ L L +E + ++ + E E ++ +G
Sbjct: 1623 LLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSG 1672
Score = 110 bits (274), Expect = 3e-23
Identities = 161/736 (21%), Positives = 301/736 (40%), Gaps = 121/736 (16%)
Query: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
L ++ELE +++ L+KE ++++ +++ ++ K K+++++ ++E Q + E
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS-------RKETQTVKEEL 995
Query: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
ESL K ++S ++ + L +KQ E+L+ E +R + R + +
Sbjct: 996 ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR 1055
Query: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
S C T S EDL + K LE ++ +Q KA
Sbjct: 1056 NSTLQCET---------------INSDNEDLLARIETLQSNAKLLEVQILEVQRAKA--- 1097
Query: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
M +++ + +++K H ++ ++ ++ ++++ +
Sbjct: 1098 -----MVDKELEAEKLQ------KEQKIKEHATTVNELEELQVQLQKE----KKQLQKTM 1142
Query: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316
L++ K+DA + N +K NQ+L NK N++E E+E+K Q K +
Sbjct: 1143 QELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE----DLEQEIKIQKQKQE 1198
Query: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRT---TAQYDQASTKYTALEQKLKKLTEDLSC 373
LQ ++ + + + E+ K + LV+T A QA T + L+ LK +L
Sbjct: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK---GELEA 1255
Query: 374 QRQNAESARCSLEQKIKEKEK----------EFQEELSRQQRSFQTLDQECIQMKAR--- 420
+Q E + L + EK K + Q LS Q+ L +EC KA
Sbjct: 1256 SQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQAT 1315
Query: 421 LTQELQQAK-NMHNVL---------QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
+T E + K +HNVL QAE + ++ LE +++ K KL + +
Sbjct: 1316 VTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL---QDSQNNL 1372
Query: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK--- 527
QI +EL + ++ E++ L + +E EAEL+ K C QS+N + +
Sbjct: 1373 QINVSEL----QTLQSEHDTLLERHNKMLQETVSKEAELRE-KLCSIQSENMMMKSEHTQ 1427
Query: 528 --AKNTSQETMLRDL---QEKINQQENSLTLEKLKLAVADLEKQR-------------DC 569
++ TSQ +LR+ Q + Q+E+ T+E L+ ++ +E Q
Sbjct: 1428 TVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSS 1487
Query: 570 SQDLLKKREHHIEQL------------NDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Q L RE L + + T+ ES + S ++ E K
Sbjct: 1488 QQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKL 1547
Query: 618 LFSCWKSE--NEKLLTQMES---EKENLQSKINHLE--TCLKTQQIKSHEYNERVRTLEM 670
W +E E+L+ ++ S ++L + E + +QIK + R
Sbjct: 1548 EPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQ 1607
Query: 671 DRENLSVEIRNLHNVL 686
+RE + + L NVL
Sbjct: 1608 EREKSAANLEYLKNVL 1623
Score = 55.1 bits (131), Expect = 1e-06
Identities = 97/485 (20%), Positives = 186/485 (38%), Gaps = 58/485 (11%)
Query: 14 TRALQKIQELEGQLDKLKKEKQQR-QFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
T KI++LE ++ K++K+KQ+ Q ++ SL++++Q+ ++K K K+E
Sbjct: 1177 TNKNNKIEDLEQEI-KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS 1235
Query: 73 MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
+ + + EL+ + QV + QL + K+ + LK + +R+ A
Sbjct: 1236 KQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAY 1295
Query: 133 QSADVSL-NPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Q +L C + T + + Y + LK++ NK + + E E + +
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ---AETEGAKQERE 1352
Query: 192 KASQTLPQATMNHRDIARH-QASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
+ Q + +D + Q + S Q + + L +++ S E
Sbjct: 1353 HLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK-------MLQETVSKEA 1405
Query: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
E+ ++Q + + S + QL +QN+ LRN + LQ ++
Sbjct: 1406 ELREKLCSIQ------SENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK--- 1456
Query: 311 QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED 370
+ LQ QL K + +L + + + + + +Q LK L E
Sbjct: 1457 ---TVETLQQQLSKMEAQLFQLKN----------------EPTTRSPVSSQQSLKNLRE- 1496
Query: 371 LSCQRQNAESARCSLEQKIKEK----EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
R+N + + +E+ E E +S Q+L+Q + +L L
Sbjct: 1497 ----RRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLW 1552
Query: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK--ENELRRSMEEM 484
A+ L +L T L L E A A QIK ++E+RR
Sbjct: 1553 HAEFTKEELVQKLSSTTKSADHLNGLLRE-----TEATNAILMEQIKLLKSEIRRLERNQ 1607
Query: 485 KKENN 489
++E +
Sbjct: 1608 EREKS 1612
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 186 bits (472), Expect = 3e-46
Identities = 234/1132 (20%), Positives = 521/1132 (46%), Gaps = 151/1132 (13%)
Query: 1791 EDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFS 1850
++ + K+ +LL E +L ++Q+ + E + E+ +L K L K++
Sbjct: 877 KELEEKMVTLLKEKNDL-------QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK--- 926
Query: 1851 CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
E+ +R E E +N++L A K ED + K D + VE E ++
Sbjct: 927 ----EVTERAEDEEEINAELT--AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
++ E L+ + + EK L++ ++ + E++++ +T + +L ++D
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD- 1039
Query: 1971 SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
L+ E+ K+ +LE + + +++A+ + + ++ + E LK K
Sbjct: 1040 ------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD----IENEKQQLDEKLKKK 1089
Query: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
LQS +D QAL + +L+ +I +L E L +E E+ +A ++++ ++ ++S
Sbjct: 1090 EFEISNLQSKIEDEQALGI---QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
+ LE + E+ E A +S Q E+++ +R E ++R + +E H A R++ D
Sbjct: 1147 RELEE-ISERLEEAGGATSAQIEMNK-KREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 2151 S---LKDKVENLERELQMSEENQELVILDAENSKAEVETL---KTQIEEMARSLK--VFE 2202
S L ++++NL+R Q E+ + + ++ ++ + VET+ K +E+M R+L+ + E
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 2203 L------------DLVT----LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQ 2245
L DL L++E ++Q+ EK+ +S+L + +F +EE K Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 2246 AEIQIK---------EESKTAVEMLQNQLKELNEAVAALC-----GDQEIMKATEQSLDP 2291
E +IK + S+ ++L+ Q +E E+ A L + E+ + +
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
I+ +L + +KL RL+A E+ V + E L+ VE+L L++ RTN
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM--LDVERTN 1442
Query: 2352 QEHAALEAENS---------KGEVETLKAKIEGMTQSLRGLELDVV-------------- 2388
AAL+ + K + E A++E + R L ++
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
T++ E +NL E+ E+I+E E I ++ EQEK +++ A+E + L+
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ----AALEEAEASLE 1558
Query: 2449 ELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYI----VLQSSVN 2504
++ + + K++ ++ + A+ + +D+ K N+I +QS+++
Sbjct: 1559 HEEGKILRIQLELNQVKSE----------VDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 2505 GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK-LSQVEGEHQLWKEQNLELRNLT- 2562
I+ D + +K + +++ ++ Q+ ++ ++ L + K+ + L +
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 2563 --VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
+L++++ +++ + LQ +E L+++ + E ++ + + + E+V + + T
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS----ELKK 2676
L +++L + +++ GE++ +L+E ++++++ K+ + + ELKK
Sbjct: 1729 L-----------INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 2677 SLDCM-HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
D H ++++K + + + + QLRL EAE+ L L K+ +++ +L +
Sbjct: 1778 EQDTSAHLERMKKN--MEQTVKDLQLRLDEAEQ----LALKGGKKQIQKLEARVRELEGE 1831
Query: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
E S QK + +K ++ + T Q E+ K + +L+ ++ Q K+
Sbjct: 1832 VE--SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN--------ILRLQDLVDKLQAKV 1881
Query: 2796 KLLIKSCKQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTTEIKEL 2846
K + ++ EE+ + +LQ +E ++ + +++V++L + +E+
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 166 bits (421), Expect = 3e-40
Identities = 232/1161 (19%), Positives = 492/1161 (42%), Gaps = 150/1161 (12%)
Query: 1812 HLQEVQLMTKIEACI---ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNS 1868
H ++L KI+ + E EK + +K+E + ++L +EL +++ T +
Sbjct: 832 HWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKN 891
Query: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
DL++ ++ E + D + + K + + +E ++ + +E+A E E + A+L
Sbjct: 892 DLQLQV-QAEAEGLADAEERCDQLIKTK-IQLEAKIKEV-TERAEDEEE---INAELTA- 944
Query: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
+K LE + +K I LE L+ V E++ ++ ++++ LD+ K+ ++
Sbjct: 945 --KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
+ L+ + L +Q E +V T+ L V +L ++ LE+ + L
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
+ I + EK + L +L + ++E N+ +E E AL +
Sbjct: 1063 GDLKLAQESIMDIENEK-------QQLDEKLKKKEFEISNLQSKIE------DEQALGI- 1108
Query: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
Q+++ +L+ IE+L IEA+ + ++ + RE + + +++E E
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLS 2227
+ + + + ++E Q E A +L+ D V L + +NL + Q+ + + S
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
E+ + S +E +A+ +++ +T + L ++LK E L D + Q
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL-SELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 2288 S----LDPPIEEEHQL-----------RNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
+ ++E+ L IE+L+ +LE + K + + L+ S H D
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
LL+ E E E E A L+ SK E + + + T +++ E +
Sbjct: 1348 LLR---EQYEEEQE------SKAELQRALSKANTEVAQWRTKYETDAIQRTE----ELEE 1394
Query: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK---EKSSTAMEMLQTQ--- 2446
K+ L LQ +E + + +S E Q + E + E+++ A L +
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454
Query: 2447 ----LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
L E ++ H + EA + + ++L +++ ++ + L L+ K LQ
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514
Query: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562
++ L +++ +G +++ E+ ++K Q+ +QE+ + + E E L E+ LR +
Sbjct: 1515 ISDLTEQIAEGGKRI----HELEKIKKQV-EQEKCELQAALEEAEASLEHEEGKILR-IQ 1568
Query: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSY----KNLENELELTKMDKMSFVEKVNKMTAKE 2618
+EL Q + K A + ++ L+ ++ +++++ L+ + + KM
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE-----------L 2667
E++ +++ + AE + L + Q+ L++ S++ LKE L
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL------LLDTNKQY 2721
E EL+ +L +Q E+ K+ E+ L +A ++ Q L L++T K+
Sbjct: 1688 QAEIEELRATL-----EQTERSRKIAEQ------ELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 2722 EVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2781
E +I + ++ E+ L ++++E+ ++ + EELKK + D ++
Sbjct: 1737 ETDISQMQGEM---EDILQE-------ARNAEEKAKKAITDAAMMAEELKK-EQDTSAHL 1785
Query: 2782 NQLKKENERAQGKMKLLIKSCKQL-----------------EEEKEILQKELSQLQA--- 2821
++KK E+ ++L + +QL E E E+ ++ +A
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG 1845
Query: 2822 --------------AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL 2867
+E +K + VD+L ++K K EE ++++ L K+ L
Sbjct: 1846 LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Query: 2868 LISHEKLEKAKEMLETQVAHL 2888
E+ E+ ++ E+QV L
Sbjct: 1906 QHELEEAEERADIAESQVNKL 1926
Score = 163 bits (412), Expect = 3e-39
Identities = 232/1051 (22%), Positives = 445/1051 (42%), Gaps = 148/1051 (14%)
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
EK+ ++ +++EL+ ++R +L ++ T+ K+ L + E + E
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911
Query: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
+ + EA++KE TE + +EL K L+++ L+KD L LT ++E
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 2056 NQ---------------------IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
+ IA+L KEK+ L E+ Q L + E+ V+ L
Sbjct: 972 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL---QEAHQQTLDDLQAEEDKVN-TLT 1027
Query: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD-----------EKKQLHIAEKLK 2143
A ++ + L + E+ +LR +E+ + ++E D E ++ + EKLK
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 2144 ERERENDSLKDKVENLER-ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
++E E +L+ K+E+ + +Q+ ++ +EL +A +E L+ +IE S E
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKEL--------QARIEELEEEIEAERASRAKAE 1139
Query: 2203 LDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLEEKEQAEIQ-------IK 2251
L E E ++++++E G Q+ K + F+ + + E+A +Q ++
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 2252 EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
++ +V L Q+ L L ++ MK L +E + + ++EK+ LE
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 2312 ADEKKQLCVLQQLKESEHHA--DLLKGRVENLERELEIARTNQEHAALEAENSKG----- 2364
QL L+ +E + DL R E +R E AL ++ S+G
Sbjct: 1260 ----DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 2365 -EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423
++E LK ++E ++ L + + R + + L + ++EQE +EL + L
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL-------QRALS 1368
Query: 2424 EKEQEKVQMKEKSST----AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
+ E Q + K T E L+ K+L +R+ A EA AK C
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK---------CAS 1419
Query: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
LEK + L EVED +E+ + + L + ++ +++++
Sbjct: 1420 LEKTK-------------------QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 2540 KLSQ-VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL- 2597
+ Q E H + E R+L EL ++ + SL D LE L+ KNL+ E+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTEL---FKIKNAYEESL-DQLETLKRENKNLQQEIS 1516
Query: 2598 ELTKM-----DKMSFVEKVNKMTAKE-TELQREMHEMAQKTAELQE----ELSGEKNRLA 2647
+LT+ ++ +EK+ K +E ELQ + E A+ + E +E + E N++
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE-AEASLEHEEGKILRIQLELNQVK 1575
Query: 2648 GELQLLLEEIKSSKDQLKELTLENSE-LKKSLDC---MHKDQVEKEGKVREEIAEYQLRL 2703
E+ + E DQLK + E ++ +LD D + + K+ ++ E +++L
Sbjct: 1576 SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL 1635
Query: 2704 HEAE----------KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
+ A + Q +L DT ++ + +E L+ + +LL++
Sbjct: 1636 NHANRMAAEALRNYRNTQGILKDT----QIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
EEL +L+ T + + ++ +D + V L +N K L Q++ E E +
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL 1751
Query: 2814 KELSQLQAAQEKQKTGTVMDT----KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
+E + +K T M K + + ++ +K+ +E+ K+ LD+ L +
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 2870 SHEKLEKAKEMLETQVAHLCSQQSKQDSRGS 2900
K K + LE +V L + + R +
Sbjct: 1812 KGGK--KQIQKLEARVRELEGEVESEQKRNA 1840
Score = 145 bits (367), Expect = 5e-34
Identities = 222/1115 (19%), Positives = 476/1115 (42%), Gaps = 143/1115 (12%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQKQKQKVEN 57
K +ELE ++ L KEK Q Q+ + LEA +++ ++ E+
Sbjct: 875 KRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAED 934
Query: 58 EKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117
E+ L + ++L + C L+K + L E + + E ++ + +++ L++
Sbjct: 935 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET 994
Query: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL------KEKY 171
+ + E + Q+A Q +L+ + T LT ++ + +DL ++K
Sbjct: 995 IAKLTKEKKALQEAHQQ---TLDDLQAEEDKVNT-LTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 172 NKEVEERKR-LEAEVKALQ---------AKKASQTLPQATMNHRDIARHQASSSVFSWQQ 221
++E KR LE ++K Q ++ + L + ++ Q
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQL 1110
Query: 222 EKTPSHLSSNSQ--RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
+K L + + I + ++ + +Q SR +I +R + S+ +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-LEEAGGATSAQIEM 1169
Query: 280 LDQLKAQNQELRNKINELELRLQG-----------HEKEMKGQVNKFQELQLQLEKAKVE 328
+ +A+ Q++R + E L+ + E+ Q++ Q ++ +LEK K E
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 329 -------LIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESA 381
L + ++K + L + + ++ + E++ ++L DL+ QR ++
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE 1289
Query: 382 RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
+++ EKE +LSR +++F Q+ ++K +L +E++ + + LQ+
Sbjct: 1290 SGEFSRQLDEKE-ALVSQLSRGKQAF---TQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 442 LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501
+++Q E +E K +L RA L ++ E+ + ++ + Q+ E
Sbjct: 1346 CDLLREQYEEE-QESKAELQRA-------------LSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561
LE K + Q L ++ E + AK S E + LQ ++ ++ L +E+ A A
Sbjct: 1392 ---LEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV--EDLMLDVERTNAACA 1446
Query: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFS 620
L+K++ +L + + E+ + +L ++KE+++L + L K YEE L + +TL
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL-- 1504
Query: 621 CWKSENEKLLTQMESEKENLQ---SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV 677
K EN+ L ++ E + +I+ LE K + + E + E E+
Sbjct: 1505 --KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 678 EIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQV----- 732
+I + L+ EV+ ++ +K E DQ + I + S L ++
Sbjct: 1563 KILRIQLELNQVKSEVD------RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 733 -----EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF 787
+ +E L + ++ +R + Y + + +LK L +D RS
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL---DDALRSQEDL 1673
Query: 788 DQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
+Q AM AN+ + +E E R +Q+ ++ I + + ++ N+
Sbjct: 1674 KEQLAMVERRANL------LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 848 DL---QKQCE-ELVQIKGEIEENLMK---AEQMHQSFVAETSQRISKL--QEDTSAHQNV 898
L +K+ E ++ Q++GE+E+ L + AE+ + + + + +L ++DTSAH
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
+ + +E K+LQL D E EQ ++ KK LE ++EL+ E S +K+
Sbjct: 1788 MKKN---MEQTVKDLQLRLD--EAEQLALKGGKKQIQKLEARVRELE--GEVESEQKRNA 1840
Query: 959 SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
++ L K E +KE+ +++ N++ + + + + + KS +++
Sbjct: 1841 EAVKGLRKHE--------RRVKELTYQTEEDRKNIL-RLQDLVDKLQAKVKSYKRQAEEA 1891
Query: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
+++ L + + + E+ ++ A+ + +KL
Sbjct: 1892 EEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 142 bits (357), Expect = 7e-33
Identities = 215/1097 (19%), Positives = 461/1097 (42%), Gaps = 142/1097 (12%)
Query: 328 ELIEKEKVLNKCRDELVRTTAQYDQASTKY---TALEQKLKKLTEDLSCQRQNAESARCS 384
+ I+ +K K + QY TK L L+++ +D Q ARC
Sbjct: 740 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARC- 798
Query: 385 LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE-LDKLT 443
+ E+Q + R++ F CIQ R ++ M + + L K
Sbjct: 799 ---RGFLARVEYQRMVERREAIF------CIQYNIRSFMNVKHWPWMKLFFKIKPLLKSA 849
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR--- 500
++++ EEF+ + + S+ K EL M + KE N L+ + +A
Sbjct: 850 ETEKEMATMKEEFQ----KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 501 ---EVC--------HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN 549
E C LEA++K + + + E+ AK E +L++ I
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI----- 960
Query: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL-------LSAL 602
+ L+L +A +EK++ +++ +K + L++ ++K KE KAL L L
Sbjct: 961 ----DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
+ ++ + L + K + E L Q + + +L+ LE LK Q +
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE 1076
Query: 663 ERVRTLEMDRENLSVEIRNLHN-VLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENM 721
+ L+ + EI NL + + D +++ ++ QK ELQ + E +++ + E +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK-KIKELQARIEELEEEIEAERASR 1135
Query: 722 C---LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL-RDL----LKSKDAS 773
+ S L+ ++E++ +L+ + + AE++ + RDL L+ + +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN--------- 824
+ H S+ +Q N+ + + E+SE ++E D N
Sbjct: 1196 ATLRKKHADSVAELGEQ------IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 825 -----SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM------ 873
L++++ L+ E Q+++ +DL Q L GE L + E +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 874 -HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Q+F + + +L+E+ A +N +A AL++ + LL ++ E EQ EL++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKA-KNALAH---ALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 933 SNHLLEDSLKELQLLSETLSLE--------KKEMSSIISLNKREIEELTQENGTLKEINA 984
+ + + + ET +++ KK+++ + + +E + + +L++
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425
Query: 985 SLNQEKMNL---IQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQ 1041
L E +L ++++ + +D+++++ ++ ++K Q+CEET
Sbjct: 1426 RLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK-------QKCEET-------HA 1471
Query: 1042 KYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
+ +A+Q++ L L + + E ++LE LK K Q+ ++ L +
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE-NKNLQQEISDLTEQIAEGGKRIH 1530
Query: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQE---IMTLKEEQNKMQKEVNDLLQENEQLMK 1158
ELE +++ + E + Q + L+ E I+ ++ E N+++ EV+ + E ++ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAM-- 1216
+K H + +ES + R S + K +M+ ++ E+ + +A + EA+
Sbjct: 1591 QLKRNH-IRIVESMQSTLDAEIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648
Query: 1217 -------LRNKELKLQESEKEKECLQHELQTI--RGDLETSNLQDMQSQEISGLKDCEID 1267
L++ ++ L ++ + +E L+ +L + R +L + ++++++ + +I
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI- 1707
Query: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR-- 1325
AE++ + + N L +N +LE +Q E +++ E ++
Sbjct: 1708 AEQELLDASERVQLLHTQNTSL-------INTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 1326 -SECITATRKMAEEVGK 1341
+ IT MAEE+ K
Sbjct: 1761 AKKAITDAAMMAEELKK 1777
Score = 140 bits (354), Expect = 1e-32
Identities = 213/1068 (19%), Positives = 437/1068 (40%), Gaps = 152/1068 (14%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + K ++LE + +LKK+ + L +E + KV+N E L
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQ 116
+L + ++L++ Q+ +LQ +E +VN Q L +Q +KL
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 117 ELKRCKSELERSQQAAQSA--DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK------ 168
+L+R K +LE + AQ + D+ +K+ S S K ED +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS--KIEDEQALGIQL 1110
Query: 169 EKYNKEVEER-KRLEAEVKALQAKKASQTLPQATMNHRDIARH-QASSSVFSWQQEKTPS 226
+K KE++ R + LE E++A +A +A +A D++R + S T +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRA-----KAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 227 HLSSNSQRTP----IRRDFSASYFSGEQEVTPSR-----STLQIGKRDANSSFFDNSSSP 277
+ N +R +RRD + E R S ++G++ N
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ-------- 1217
Query: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKF-QELQLQLEKAKVELIEKEKVL 336
+ +L+ + E++ +I++L ++ K KG + K + L+ QL + K + E+++++
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKA-KGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK------ 390
N + R + + S + E + +L+ Q E + LE++IK
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 391 -----------------EKEKEFQEELSR----------QQRSFQTLD-----QECIQMK 418
E+E+E + EL R Q R+ D +E + K
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
+L Q LQ A+ + A+ L KQ+L+N +E+ + R A A K+
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
+ + E K++ + E +E L EL IK +S + E +K +N + + +
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 539 DLQEKINQQENSL-TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
DL E+I + + LEK+K V E+++ Q L++ E +E K+ + + E
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQV---EQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
+ S ++ K E +E ++ K + +++ M+S L ++I ++ ++
Sbjct: 1574 VKSEVDRKIAEKDEEIDQ------LKRNHIRIVESMQS---TLDAEIRSRNDAIRLKKKM 1624
Query: 658 SHEYNERVRTLEMDRENLSVEIRNLHN---VLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
+ NE L + +RN N +L + ++ + +L+++ +++
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 715 ---QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Q EIE +L +E E ++ E++D Q LH + SL + K +
Sbjct: 1685 NLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
+ + + GE + E +A ++ ++A++
Sbjct: 1738 TDI-----------------------SQMQGEMEDILQEARNAEEKAKKAITDAAMMAE- 1773
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM----HQSFVAETSQRISK 887
L+ ++ ++ L++ + + Q +++ L +AEQ+ + + + R+ +
Sbjct: 1774 ------ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827
Query: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
L+ + + Q AE + L E+ ++ L + E ++ I L+ L+ +K +
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
+E E +E S+ R+++ +E E A + + ++N ++
Sbjct: 1888 AE----EAEEQSNTNLAKFRKLQHELEE----AEERADIAESQVNKLR 1927
Score = 134 bits (337), Expect = 1e-30
Identities = 243/1153 (21%), Positives = 483/1153 (41%), Gaps = 158/1153 (13%)
Query: 305 EKEMKGQVNKFQELQLQLEKAKV---ELIEKEKVLNKCRDEL---VRTTAQ--------Y 350
EKEM +FQ+++ +L K++ EL EK L K +++L V+ A+
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911
Query: 351 DQASTKYTALEQKLKKLTE----------DLSCQRQNAESARCSLEQKIKEKE---KEFQ 397
DQ LE K+K++TE +L+ +++ E L++ I + E + +
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 398 EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK 457
+E + + L +E + + + ++ K + Q LD L + + ++ N L + K
Sbjct: 972 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV-NTLTKAK 1030
Query: 458 QKLCRAEQAFQASQIKENELRRSMEEMKK----ENNLLKSHSEQKAREVCHLEAELKNIK 513
KL + + S +E +LR +E K+ + L + E L+ +LK +
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 514 QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR-DCSQD 572
++ Q+ E+ +A + +++LQ +I + E + E+ A A EKQR D S++
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA--EKQRSDLSRE 1148
Query: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK---EEKTL-----FSCWKS 624
L E+++++L + + A + + ++ E+++++ EE TL + +
Sbjct: 1149 L--------EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
++ + ++ + +NLQ LE +++ + V T+ + NL R L +
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260
Query: 685 VL-DSKSVEVETQKLAYMELQQK-------AEFSDQKHQKE--IENMCLKTSQLTGQVED 734
L + KS E E Q+L Q+ EFS Q +KE + + T Q+E+
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM- 793
L+ +L+ EI K+ L + L + + + + QR+L + + A
Sbjct: 1321 LKRQLE---EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 794 ---HHSFANIIGEQGSMPSERSECRLEADQS------------PKNSAILQNRVDSLEFS 838
+ + A E+ ++ RL+A + K LQN V+ L
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
+E + L K+ +I E ++ K E+ H A + S L + +N
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQ---KCEETHAELEASQKEARS-LGTELFKIKNA 1493
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
E+L LE ++E + L ++ +I E K H EL+ + + + EK E+
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH-------ELEKIKKQVEQEKCEL 1546
Query: 959 SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
+ + + +E E G + I LNQ K + +K I E+++ I DQ
Sbjct: 1547 QAALEEAEASLE---HEEGKILRIQLELNQVKSEVDRK-------IAEKDEEI----DQL 1592
Query: 1019 KQEKLILLQRCEETGNA----YEDLSQKYKAAQEKNSKLECLLNECTSLC----ENRKNE 1070
K+ + +++ + T +A D + K + +++E LN + N +N
Sbjct: 1593 KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT 1652
Query: 1071 LEQLKEA------FAKEHQEFLTKLAFAEERNQNLMLELE----TVQQALRS------EM 1114
LK+ + ++ +LA E R L E+E T++Q RS E+
Sbjct: 1653 QGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Query: 1115 TDNQNNSK---SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
D + ++ L L+ + ++MQ E+ D+LQE + K + +
Sbjct: 1713 LDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
Query: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
E ++ KE+++ + K M+ VK++ L A+ +L L+ +K+
Sbjct: 1773 EELK---KEQDTSAHLERMKKNMEQTVKDLQLRLDEAE-----------QLALKGGKKQI 1818
Query: 1232 ECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC 1291
+ L+ ++ + G++E+ Q ++ + GL+ K+ EL+ ++
Sbjct: 1819 QKLEARVRELEGEVESE--QKRNAEAVKGLR--------KHERRVKELTYQTEEDRKNIL 1868
Query: 1292 SLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL-NEVKILN 1350
LQ ++KL K + QAE+ E + N ++ + + AEE + ++V L
Sbjct: 1869 RLQDLVDKLQAKVKSYK-RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Query: 1351 DDSGLLHGELVED 1363
S +H +++ +
Sbjct: 1928 VKSREVHTKVISE 1940
Score = 129 bits (325), Expect = 3e-29
Identities = 229/1164 (19%), Positives = 469/1164 (40%), Gaps = 130/1164 (11%)
Query: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
KL + L K + +++ +E +++ D+L+K+E + K L + KE +L+
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEE-FQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
+ + ++ E+ Q+ K L++KI + + ++ + E + R LE +
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 675 LSVEIRNLHNV------------------------LDSKSVEVETQKLAYMELQQKAEFS 710
L +I +L LD ++ +K A E Q+
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Q + ++ + +L QV+DLE L+ MD +R + L + LK
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-------LKLA 1068
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
S++ E+ ++ L + F E ++ S+ + + Q K LQ
Sbjct: 1069 QESIMDIENEKQQL----DEKLKKKEF-----EISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE-------QMHQSFVAETSQ 883
R++ LE +E+++ + +KQ +L + EI E L +A +M++ AE +
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
L+E T H+ T + L K + + L ++++ Q Q+L+K ++ +
Sbjct: 1180 MRRDLEEATLQHE----ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
+L ET+S K + + + ++ EL + + + L ++ L +S F+
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
+DE+E +S+LS + K Q+ EE L ++ KA L+ ++C
Sbjct: 1296 QLDEKEALVSQLS----RGKQAFTQQIEE---LKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 1063 LCENRKNELE---QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
L E + E E +L+ A +K + E + + + + E +++A + ++
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEV---AQWRTKYETDAIQRTEELEEA-KKKLAQRLQ 1404
Query: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
++ + + +L++ + ++Q EV DL ++ V +T C L+ + RN K
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDL------MLDVERTNAACAALDKKQ-RNFDK 1457
Query: 1180 ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL- 1238
+ +C + +LE + S +L +++ +L+ ++E + LQ E+
Sbjct: 1458 ILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 1239 ----QTIRGDLETSNLQDMQSQEISGLKDCEIDA--EEKYISGPHELSTSQNDNAHLQCS 1292
Q G L+ ++ Q + CE+ A EE S HE L
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQ--EKCELQAALEEAEASLEHEEGKILRIQLELNQV 1574
Query: 1293 LQTTMNKLNELEKICEILQAEKYELVTELND-------SRSECITATRKMAEEVGKLLNE 1345
K+ E ++ + L+ +V + SR++ I +KM + LNE
Sbjct: 1575 KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD----LNE 1630
Query: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFA 1405
++I + + + E + + + G + Q + A + + E L + ++ + A
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQ-GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 1406 ELQEKFLSLQS---EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK 1462
E++E +L+ KI + S ++ L T SL L T++ QG++
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 1463 EMQLGLEEGLVPSLSSSCVPDSSSLS-SLGDSSFYRALLEQTGDMSLLSNLEGAVSANQC 1521
+Q E + + D++ ++ L A LE+ + N+E V Q
Sbjct: 1750 ILQ---EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-----MKKNMEQTVKDLQL 1801
Query: 1522 SVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI--MKNK 1579
+DE E L K K +++LE+ +E E+K ++ + ++
Sbjct: 1802 RLDEA-------EQLALK----GGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKH 1849
Query: 1580 EIQELEQLLSSERQELDCLRKQYLSENEQ-----WQQKLTSVTLEMESKLAAEKK---QT 1631
E + E +E + LR Q L + Q ++++ + + LA +K +
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 1632 EQLSLELEVARLQLQGLDLSSRSL 1655
E+ ++A Q+ L + SR +
Sbjct: 1910 EEAEERADIAESQVNKLRVKSREV 1933
Score = 126 bits (316), Expect = 4e-28
Identities = 237/1203 (19%), Positives = 490/1203 (40%), Gaps = 162/1203 (13%)
Query: 1222 LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELST 1281
LK E+EKE ++ E Q I+ +L S + + EEK ++ L
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKE-------------LEEKMVT----LLK 888
Query: 1282 SQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341
+ND LQ +Q L + E+ C+ L K +L ++ + +T + EE+
Sbjct: 889 EKND---LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKE-----VTERAEDEEEINA 940
Query: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD-KEV 1400
L K +D EL +DI E ++LA +++ +H T + K +
Sbjct: 941 ELTAKKRKLEDEC---SELKKDIDDLE----------LTLAKVEKE---KHATENKVKNL 984
Query: 1401 QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
A L E L E K L + H Q + + V++L + L + + +G L
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ 1520
+E +L ++ RA + GD+ L + +
Sbjct: 1045 EQEKKLRMD-------------------------LERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 1521 CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580
+DE E + + + A G++ + + E+ + +E+LEE++E++ + K
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR-IEELEEEIEAERASRAK- 1137
Query: 1581 IQELEQLLSSERQELDCLRK-QYLSENEQWQQKLTSVTLEMESKLAAE----KKQTEQLS 1635
+E+Q D R+ + +SE + TS +EM K AE ++ E+ +
Sbjct: 1138 ---------AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 1636 LELEVARLQLQGLDLSSRSLLG--IDTEDAIQGRNES------CDISKEHTSETTERTPK 1687
L+ E L+ S + LG ID ++ + E +I ++ T K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 1688 HDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECIS 1747
++ ++C Q L ++ + + G ++ D+ + +S
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA---LVS 1305
Query: 1748 ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE- 1806
+LS G A + I L+ +++E L H ++ + L + +E
Sbjct: 1306 QLS-RGKQAFT--------QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 1807 LDSKLHLQEV---------QLMTKIE--ACIELEKIVGELKKENSDLSEKLEYFSCDHQE 1855
+SK LQ Q TK E A E++ KK L E+ + +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 1856 LLQRVETSEGLNSDLE--------MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRI 1907
+T + L +++E +A ++ + N K+ WK++ + EL
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
+ E S+ E ++ E + L+++N+N Q+ I L E+++ E + EL
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA----EGGKRIHEL 1532
Query: 1968 DTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL-LQTLSSDVSE 2025
+ + K+ +L ++E LE + + L IQ+ +VK + + + ++ +
Sbjct: 1533 EKIKKQVEQEKCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 2026 LLKDKTHLQEKLQS-----LEKDSQALSLTKC------ELENQIAQLNKEKELLVKESES 2074
L ++ + E +QS + + A+ L K E+E Q+ N+ ++ +
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFAL---RLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Q L ++ ++++ AL + K + A+ R + Q E+ +LR +E+ +
Sbjct: 1652 TQGILKDT---QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
E++ L +E+++ +N SL + + LE ++ + E ++ +A N++ + + T
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
MA LK + L K+N+ + +++ Q +L E ++L + K ++ ++ E +++
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVR 1826
Query: 2252 E-ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARL 2310
E E + E +N EAV L + +K + + +L++ ++KL+A++
Sbjct: 1827 ELEGEVESEQKRNA-----EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLK 2370
++ ++ Q +E+E ++ + L+ ELE A + A + + + +
Sbjct: 1882 KSYKR-------QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1934
Query: 2371 AKI 2373
K+
Sbjct: 1935 TKV 1937
Score = 123 bits (308), Expect = 3e-27
Identities = 237/1245 (19%), Positives = 496/1245 (39%), Gaps = 215/1245 (17%)
Query: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
EE ++L++ +E K+ LL E KN+L+ +A A+ L
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKE--------KNDLQLQVQAEAEG-------L 904
Query: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
A AEER L ++ + +A E+T+ + + L + L++E ++++K+++DL
Sbjct: 905 ADAEERCDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 963
Query: 1150 LQENEQLMKVMKTKHECQNLES----------EPIRNSVKERESERNQCNFKPQMDLEVK 1199
L KV K KH +N E I KE+++ + + + + DL+ +
Sbjct: 964 ---ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ-EAHQQTLDDLQAE 1019
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
E +++ ++LE + + E L++ +K + L+ + + GDL+ + M +
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 1260 GLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
D ++ +E IS ++ Q LQ ++ ++ ELE+ E +A + +
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 1319 TELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
+ +D E + ++ E G +++ +N ++ D+ E+ QH
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIE-MNKKREAEFQKMRRDL------EEATLQHE 1192
Query: 1379 VSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTY 1438
+ A L + ++ AEL E+ +LQ + L + +M ++ +L +
Sbjct: 1193 ATAATLRKKHADS------------VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498
V+++ L R + D + E++ EE R
Sbjct: 1241 VETVSKAKGNLEKMCRTLE-DQLSELKSKEEEQ------------------------QRL 1275
Query: 1499 LLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV 1558
+ + T L G S L KE V +L +
Sbjct: 1276 INDLTAQRGRLQTESGEFS----------------RQLDEKEAL------VSQLSRGKQA 1313
Query: 1559 YRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE---QWQQKLTS 1615
+ Q +E+L+ ++E + KN L L S R + D LR+QY E E + Q+ L+
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNA----LAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQL-QGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
E+ + Q + ELE A+ +L Q L + E+ ++ N C
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA---------EEHVEAVNAKCA-- 1418
Query: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734
+ E T++ +++V +DL LD+E+ C+ N++
Sbjct: 1419 ---SLEKTKQRLQNEV---------EDLMLDVERTNAA--------CAALDKKQRNFDKI 1458
Query: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKET-SNENLRLLHVIEDR 1793
+ Q E +EL S A L ++ + L ET EN L I D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 1794 DRKVES---LLNEMKELDSKLHLQEVQLMTKIEAC---------------IELEKIVGEL 1835
++ ++E++++ ++ ++ +L +E +EL ++ E+
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
++ ++ E+++ +H +++ ++++ + A+ SR D K+ E
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQST--------LDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 1896 RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV 1955
+ + N +R+ +E + D ++ + L ++D L+E+L++
Sbjct: 1631 MEIQL-NHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED----------LKEQLAM 1679
Query: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL--ESHQSECLHCIQVAEAEVKEKT 2013
V N L+ E++ + L+Q K QEL S + + LH + K+K
Sbjct: 1680 VERRANLLQAEIEELR---ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 2014 EL-LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072
E + + ++ ++L++ + +EK + D+ ++ + ++ A L + K+ + +
Sbjct: 1737 ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1796
Query: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
+ LQ RL E++ L L ++++ +L + +L +E+++
Sbjct: 1797 KDLQLRLDEAEQ--------------------LALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 2133 KKQLHIAEKLKERER---------ENDS-----LKDKVENLERELQMSEENQELVILDAE 2178
K+ + L++ ER E D L+D V+ L+ +++ + E +
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Query: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLR-SEKENLTKQIQEK 2222
+ A+ L+ ++EE + E + LR +E TK I E+
Sbjct: 1897 TNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 186 bits (472), Expect = 3e-46
Identities = 234/1132 (20%), Positives = 521/1132 (46%), Gaps = 151/1132 (13%)
Query: 1791 EDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFS 1850
++ + K+ +LL E +L ++Q+ + E + E+ +L K L K++
Sbjct: 877 KELEEKMVTLLKEKNDL-------QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK--- 926
Query: 1851 CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
E+ +R E E +N++L A K ED + K D + VE E ++
Sbjct: 927 ----EVTERAEDEEEINAELT--AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
++ E L+ + + EK L++ ++ + E++++ +T + +L ++D
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD- 1039
Query: 1971 SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
L+ E+ K+ +LE + + +++A+ + + ++ + E LK K
Sbjct: 1040 ------LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD----IENEKQQLDEKLKKK 1089
Query: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
LQS +D QAL + +L+ +I +L E L +E E+ +A ++++ ++ ++S
Sbjct: 1090 EFEISNLQSKIEDEQALGI---QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
+ LE + E+ E A +S Q E+++ +R E ++R + +E H A R++ D
Sbjct: 1147 RELEE-ISERLEEAGGATSAQIEMNK-KREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 2151 S---LKDKVENLERELQMSEENQELVILDAENSKAEVETL---KTQIEEMARSLK--VFE 2202
S L ++++NL+R Q E+ + + ++ ++ + VET+ K +E+M R+L+ + E
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 2203 L------------DLVT----LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQ 2245
L DL L++E ++Q+ EK+ +S+L + +F +EE K Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 2246 AEIQIK---------EESKTAVEMLQNQLKELNEAVAALC-----GDQEIMKATEQSLDP 2291
E +IK + S+ ++L+ Q +E E+ A L + E+ + +
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
I+ +L + +KL RL+A E+ V + E L+ VE+L L++ RTN
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM--LDVERTN 1442
Query: 2352 QEHAALEAENS---------KGEVETLKAKIEGMTQSLRGLELDVV-------------- 2388
AAL+ + K + E A++E + R L ++
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
T++ E +NL E+ E+I+E E I ++ EQEK +++ A+E + L+
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ----AALEEAEASLE 1558
Query: 2449 ELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYI----VLQSSVN 2504
++ + + K++ ++ + A+ + +D+ K N+I +QS+++
Sbjct: 1559 HEEGKILRIQLELNQVKSE----------VDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 2505 GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK-LSQVEGEHQLWKEQNLELRNLT- 2562
I+ D + +K + +++ ++ Q+ ++ ++ L + K+ + L +
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 2563 --VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
+L++++ +++ + LQ +E L+++ + E ++ + + + E+V + + T
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS----ELKK 2676
L +++L + +++ GE++ +L+E ++++++ K+ + + ELKK
Sbjct: 1729 L-----------INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 2677 SLDCM-HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
D H ++++K + + + + QLRL EAE+ L L K+ +++ +L +
Sbjct: 1778 EQDTSAHLERMKKN--MEQTVKDLQLRLDEAEQ----LALKGGKKQIQKLEARVRELEGE 1831
Query: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
E S QK + +K ++ + T Q E+ K + +L+ ++ Q K+
Sbjct: 1832 VE--SEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN--------ILRLQDLVDKLQAKV 1881
Query: 2796 KLLIKSCKQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTTEIKEL 2846
K + ++ EE+ + +LQ +E ++ + +++V++L + +E+
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 166 bits (421), Expect = 3e-40
Identities = 232/1161 (19%), Positives = 492/1161 (42%), Gaps = 150/1161 (12%)
Query: 1812 HLQEVQLMTKIEACI---ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNS 1868
H ++L KI+ + E EK + +K+E + ++L +EL +++ T +
Sbjct: 832 HWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKN 891
Query: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
DL++ ++ E + D + + K + + +E ++ + +E+A E E + A+L
Sbjct: 892 DLQLQV-QAEAEGLADAEERCDQLIKTK-IQLEAKIKEV-TERAEDEEE---INAELTA- 944
Query: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
+K LE + +K I LE L+ V E++ ++ ++++ LD+ K+ ++
Sbjct: 945 --KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
+ L+ + L +Q E +V T+ L V +L ++ LE+ + L
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
+ I + EK + L +L + ++E N+ +E E AL +
Sbjct: 1063 GDLKLAQESIMDIENEK-------QQLDEKLKKKEFEISNLQSKIE------DEQALGI- 1108
Query: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
Q+++ +L+ IE+L IEA+ + ++ + RE + + +++E E
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLS 2227
+ + + + ++E Q E A +L+ D V L + +NL + Q+ + + S
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
E+ + S +E +A+ +++ +T + L ++LK E L D + Q
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL-SELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 2288 S----LDPPIEEEHQL-----------RNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
+ ++E+ L IE+L+ +LE + K + + L+ S H D
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
LL+ E E E E A L+ SK E + + + T +++ E +
Sbjct: 1348 LLR---EQYEEEQE------SKAELQRALSKANTEVAQWRTKYETDAIQRTE----ELEE 1394
Query: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK---EKSSTAMEMLQTQ--- 2446
K+ L LQ +E + + +S E Q + E + E+++ A L +
Sbjct: 1395 AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1454
Query: 2447 ----LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
L E ++ H + EA + + ++L +++ ++ + L L+ K LQ
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQE 1514
Query: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562
++ L +++ +G +++ E+ ++K Q+ +QE+ + + E E L E+ LR +
Sbjct: 1515 ISDLTEQIAEGGKRI----HELEKIKKQV-EQEKCELQAALEEAEASLEHEEGKILR-IQ 1568
Query: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSY----KNLENELELTKMDKMSFVEKVNKMTAKE 2618
+EL Q + K A + ++ L+ ++ +++++ L+ + + KM
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE-----------L 2667
E++ +++ + AE + L + Q+ L++ S++ LKE L
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL------LLDTNKQY 2721
E EL+ +L +Q E+ K+ E+ L +A ++ Q L L++T K+
Sbjct: 1688 QAEIEELRATL-----EQTERSRKIAEQ------ELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 2722 EVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2781
E +I + ++ E+ L ++++E+ ++ + EELKK + D ++
Sbjct: 1737 ETDISQMQGEM---EDILQE-------ARNAEEKAKKAITDAAMMAEELKK-EQDTSAHL 1785
Query: 2782 NQLKKENERAQGKMKLLIKSCKQL-----------------EEEKEILQKELSQLQA--- 2821
++KK E+ ++L + +QL E E E+ ++ +A
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG 1845
Query: 2822 --------------AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSL 2867
+E +K + VD+L ++K K EE ++++ L K+ L
Sbjct: 1846 LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Query: 2868 LISHEKLEKAKEMLETQVAHL 2888
E+ E+ ++ E+QV L
Sbjct: 1906 QHELEEAEERADIAESQVNKL 1926
Score = 163 bits (412), Expect = 3e-39
Identities = 232/1051 (22%), Positives = 445/1051 (42%), Gaps = 148/1051 (14%)
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
EK+ ++ +++EL+ ++R +L ++ T+ K+ L + E + E
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911
Query: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
+ + EA++KE TE + +EL K L+++ L+KD L LT ++E
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 2056 NQ---------------------IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
+ IA+L KEK+ L E+ Q L + E+ V+ L
Sbjct: 972 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL---QEAHQQTLDDLQAEEDKVN-TLT 1027
Query: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD-----------EKKQLHIAEKLK 2143
A ++ + L + E+ +LR +E+ + ++E D E ++ + EKLK
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 2144 ERERENDSLKDKVENLER-ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
++E E +L+ K+E+ + +Q+ ++ +EL +A +E L+ +IE S E
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKEL--------QARIEELEEEIEAERASRAKAE 1139
Query: 2203 LDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLEEKEQAEIQ-------IK 2251
L E E ++++++E G Q+ K + F+ + + E+A +Q ++
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 2252 EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
++ +V L Q+ L L ++ MK L +E + + ++EK+ LE
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 2312 ADEKKQLCVLQQLKESEHHA--DLLKGRVENLERELEIARTNQEHAALEAENSKG----- 2364
QL L+ +E + DL R E +R E AL ++ S+G
Sbjct: 1260 ----DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315
Query: 2365 -EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423
++E LK ++E ++ L + + R + + L + ++EQE +EL + L
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL-------QRALS 1368
Query: 2424 EKEQEKVQMKEKSST----AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
+ E Q + K T E L+ K+L +R+ A EA AK C
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK---------CAS 1419
Query: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
LEK + L EVED +E+ + + L + ++ +++++
Sbjct: 1420 LEKTK-------------------QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 2540 KLSQ-VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL- 2597
+ Q E H + E R+L EL ++ + SL D LE L+ KNL+ E+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTEL---FKIKNAYEESL-DQLETLKRENKNLQQEIS 1516
Query: 2598 ELTKM-----DKMSFVEKVNKMTAKE-TELQREMHEMAQKTAELQE----ELSGEKNRLA 2647
+LT+ ++ +EK+ K +E ELQ + E A+ + E +E + E N++
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE-AEASLEHEEGKILRIQLELNQVK 1575
Query: 2648 GELQLLLEEIKSSKDQLKELTLENSE-LKKSLDC---MHKDQVEKEGKVREEIAEYQLRL 2703
E+ + E DQLK + E ++ +LD D + + K+ ++ E +++L
Sbjct: 1576 SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL 1635
Query: 2704 HEAE----------KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
+ A + Q +L DT ++ + +E L+ + +LL++
Sbjct: 1636 NHANRMAAEALRNYRNTQGILKDT----QIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
EEL +L+ T + + ++ +D + V L +N K L Q++ E E +
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL 1751
Query: 2814 KELSQLQAAQEKQKTGTVMDT----KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
+E + +K T M K + + ++ +K+ +E+ K+ LD+ L +
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 2870 SHEKLEKAKEMLETQVAHLCSQQSKQDSRGS 2900
K K + LE +V L + + R +
Sbjct: 1812 KGGK--KQIQKLEARVRELEGEVESEQKRNA 1840
Score = 145 bits (367), Expect = 5e-34
Identities = 222/1115 (19%), Positives = 476/1115 (42%), Gaps = 143/1115 (12%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQKQKQKVEN 57
K +ELE ++ L KEK Q Q+ + LEA +++ ++ E+
Sbjct: 875 KRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAED 934
Query: 58 EKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117
E+ L + ++L + C L+K + L E + + E ++ + +++ L++
Sbjct: 935 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET 994
Query: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL------KEKY 171
+ + E + Q+A Q +L+ + T LT ++ + +DL ++K
Sbjct: 995 IAKLTKEKKALQEAHQQ---TLDDLQAEEDKVNT-LTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 172 NKEVEERKR-LEAEVKALQ---------AKKASQTLPQATMNHRDIARHQASSSVFSWQQ 221
++E KR LE ++K Q ++ + L + ++ Q
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQL 1110
Query: 222 EKTPSHLSSNSQ--RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
+K L + + I + ++ + +Q SR +I +R + S+ +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-LEEAGGATSAQIEM 1169
Query: 280 LDQLKAQNQELRNKINELELRLQG-----------HEKEMKGQVNKFQELQLQLEKAKVE 328
+ +A+ Q++R + E L+ + E+ Q++ Q ++ +LEK K E
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 329 -------LIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESA 381
L + ++K + L + + ++ + E++ ++L DL+ QR ++
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE 1289
Query: 382 RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
+++ EKE +LSR +++F Q+ ++K +L +E++ + + LQ+
Sbjct: 1290 SGEFSRQLDEKE-ALVSQLSRGKQAF---TQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 442 LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501
+++Q E +E K +L RA L ++ E+ + ++ + Q+ E
Sbjct: 1346 CDLLREQYEEE-QESKAELQRA-------------LSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561
LE K + Q L ++ E + AK S E + LQ ++ ++ L +E+ A A
Sbjct: 1392 ---LEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV--EDLMLDVERTNAACA 1446
Query: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFS 620
L+K++ +L + + E+ + +L ++KE+++L + L K YEE L + +TL
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL-- 1504
Query: 621 CWKSENEKLLTQMESEKENLQ---SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV 677
K EN+ L ++ E + +I+ LE K + + E + E E+
Sbjct: 1505 --KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 678 EIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQV----- 732
+I + L+ EV+ ++ +K E DQ + I + S L ++
Sbjct: 1563 KILRIQLELNQVKSEVD------RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 733 -----EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF 787
+ +E L + ++ +R + Y + + +LK L +D RS
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHL---DDALRSQEDL 1673
Query: 788 DQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
+Q AM AN+ + +E E R +Q+ ++ I + + ++ N+
Sbjct: 1674 KEQLAMVERRANL------LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 848 DL---QKQCE-ELVQIKGEIEENLMK---AEQMHQSFVAETSQRISKL--QEDTSAHQNV 898
L +K+ E ++ Q++GE+E+ L + AE+ + + + + +L ++DTSAH
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
+ + +E K+LQL D E EQ ++ KK LE ++EL+ E S +K+
Sbjct: 1788 MKKN---MEQTVKDLQLRLD--EAEQLALKGGKKQIQKLEARVRELE--GEVESEQKRNA 1840
Query: 959 SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
++ L K E +KE+ +++ N++ + + + + + KS +++
Sbjct: 1841 EAVKGLRKHE--------RRVKELTYQTEEDRKNIL-RLQDLVDKLQAKVKSYKRQAEEA 1891
Query: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
+++ L + + + E+ ++ A+ + +KL
Sbjct: 1892 EEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 142 bits (357), Expect = 7e-33
Identities = 215/1097 (19%), Positives = 461/1097 (42%), Gaps = 142/1097 (12%)
Query: 328 ELIEKEKVLNKCRDELVRTTAQYDQASTKY---TALEQKLKKLTEDLSCQRQNAESARCS 384
+ I+ +K K + QY TK L L+++ +D Q ARC
Sbjct: 740 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARC- 798
Query: 385 LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE-LDKLT 443
+ E+Q + R++ F CIQ R ++ M + + L K
Sbjct: 799 ---RGFLARVEYQRMVERREAIF------CIQYNIRSFMNVKHWPWMKLFFKIKPLLKSA 849
Query: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR--- 500
++++ EEF+ + + S+ K EL M + KE N L+ + +A
Sbjct: 850 ETEKEMATMKEEFQ----KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 501 ---EVC--------HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN 549
E C LEA++K + + + E+ AK E +L++ I
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI----- 960
Query: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL-------LSAL 602
+ L+L +A +EK++ +++ +K + L++ ++K KE KAL L L
Sbjct: 961 ----DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662
+ ++ + L + K + E L Q + + +L+ LE LK Q +
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE 1076
Query: 663 ERVRTLEMDRENLSVEIRNLHN-VLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENM 721
+ L+ + EI NL + + D +++ ++ QK ELQ + E +++ + E +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK-KIKELQARIEELEEEIEAERASR 1135
Query: 722 C---LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL-RDL----LKSKDAS 773
+ S L+ ++E++ +L+ + + AE++ + RDL L+ + +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN--------- 824
+ H S+ +Q N+ + + E+SE ++E D N
Sbjct: 1196 ATLRKKHADSVAELGEQ------IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 825 -----SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM------ 873
L++++ L+ E Q+++ +DL Q L GE L + E +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 874 -HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Q+F + + +L+E+ A +N +A AL++ + LL ++ E EQ EL++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKA-KNALAH---ALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 933 SNHLLEDSLKELQLLSETLSLE--------KKEMSSIISLNKREIEELTQENGTLKEINA 984
+ + + + ET +++ KK+++ + + +E + + +L++
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425
Query: 985 SLNQEKMNL---IQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQ 1041
L E +L ++++ + +D+++++ ++ ++K Q+CEET
Sbjct: 1426 RLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWK-------QKCEET-------HA 1471
Query: 1042 KYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
+ +A+Q++ L L + + E ++LE LK K Q+ ++ L +
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE-NKNLQQEISDLTEQIAEGGKRIH 1530
Query: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQE---IMTLKEEQNKMQKEVNDLLQENEQLMK 1158
ELE +++ + E + Q + L+ E I+ ++ E N+++ EV+ + E ++ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAM-- 1216
+K H + +ES + R S + K +M+ ++ E+ + +A + EA+
Sbjct: 1591 QLKRNH-IRIVESMQSTLDAEIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648
Query: 1217 -------LRNKELKLQESEKEKECLQHELQTI--RGDLETSNLQDMQSQEISGLKDCEID 1267
L++ ++ L ++ + +E L+ +L + R +L + ++++++ + +I
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI- 1707
Query: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR-- 1325
AE++ + + N L +N +LE +Q E +++ E ++
Sbjct: 1708 AEQELLDASERVQLLHTQNTSL-------INTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 1326 -SECITATRKMAEEVGK 1341
+ IT MAEE+ K
Sbjct: 1761 AKKAITDAAMMAEELKK 1777
Score = 140 bits (354), Expect = 1e-32
Identities = 213/1068 (19%), Positives = 437/1068 (40%), Gaps = 152/1068 (14%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + K ++LE + +LKK+ + L +E + KV+N E L
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQ 116
+L + ++L++ Q+ +LQ +E +VN Q L +Q +KL
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 117 ELKRCKSELERSQQAAQSA--DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK------ 168
+L+R K +LE + AQ + D+ +K+ S S K ED +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS--KIEDEQALGIQL 1110
Query: 169 EKYNKEVEER-KRLEAEVKALQAKKASQTLPQATMNHRDIARH-QASSSVFSWQQEKTPS 226
+K KE++ R + LE E++A +A +A +A D++R + S T +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRA-----KAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 227 HLSSNSQRTP----IRRDFSASYFSGEQEVTPSR-----STLQIGKRDANSSFFDNSSSP 277
+ N +R +RRD + E R S ++G++ N
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ-------- 1217
Query: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKF-QELQLQLEKAKVELIEKEKVL 336
+ +L+ + E++ +I++L ++ K KG + K + L+ QL + K + E+++++
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKA-KGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK------ 390
N + R + + S + E + +L+ Q E + LE++IK
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 391 -----------------EKEKEFQEELSR----------QQRSFQTLD-----QECIQMK 418
E+E+E + EL R Q R+ D +E + K
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
+L Q LQ A+ + A+ L KQ+L+N +E+ + R A A K+
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
+ + E K++ + E +E L EL IK +S + E +K +N + + +
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 539 DLQEKINQQENSL-TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
DL E+I + + LEK+K V E+++ Q L++ E +E K+ + + E
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQV---EQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
+ S ++ K E +E ++ K + +++ M+S L ++I ++ ++
Sbjct: 1574 VKSEVDRKIAEKDEEIDQ------LKRNHIRIVESMQS---TLDAEIRSRNDAIRLKKKM 1624
Query: 658 SHEYNERVRTLEMDRENLSVEIRNLHN---VLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
+ NE L + +RN N +L + ++ + +L+++ +++
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 715 ---QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Q EIE +L +E E ++ E++D Q LH + SL + K +
Sbjct: 1685 NLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
+ + + GE + E +A ++ ++A++
Sbjct: 1738 TDI-----------------------SQMQGEMEDILQEARNAEEKAKKAITDAAMMAE- 1773
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM----HQSFVAETSQRISK 887
L+ ++ ++ L++ + + Q +++ L +AEQ+ + + + R+ +
Sbjct: 1774 ------ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827
Query: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
L+ + + Q AE + L E+ ++ L + E ++ I L+ L+ +K +
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
+E E +E S+ R+++ +E E A + + ++N ++
Sbjct: 1888 AE----EAEEQSNTNLAKFRKLQHELEE----AEERADIAESQVNKLR 1927
Score = 134 bits (337), Expect = 1e-30
Identities = 243/1153 (21%), Positives = 483/1153 (41%), Gaps = 158/1153 (13%)
Query: 305 EKEMKGQVNKFQELQLQLEKAKV---ELIEKEKVLNKCRDEL---VRTTAQ--------Y 350
EKEM +FQ+++ +L K++ EL EK L K +++L V+ A+
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911
Query: 351 DQASTKYTALEQKLKKLTE----------DLSCQRQNAESARCSLEQKIKEKE---KEFQ 397
DQ LE K+K++TE +L+ +++ E L++ I + E + +
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 398 EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK 457
+E + + L +E + + + ++ K + Q LD L + + ++ N L + K
Sbjct: 972 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV-NTLTKAK 1030
Query: 458 QKLCRAEQAFQASQIKENELRRSMEEMKK----ENNLLKSHSEQKAREVCHLEAELKNIK 513
KL + + S +E +LR +E K+ + L + E L+ +LK +
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 514 QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR-DCSQD 572
++ Q+ E+ +A + +++LQ +I + E + E+ A A EKQR D S++
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA--EKQRSDLSRE 1148
Query: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK---EEKTL-----FSCWKS 624
L E+++++L + + A + + ++ E+++++ EE TL + +
Sbjct: 1149 L--------EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
++ + ++ + +NLQ LE +++ + V T+ + NL R L +
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED 1260
Query: 685 VL-DSKSVEVETQKLAYMELQQK-------AEFSDQKHQKE--IENMCLKTSQLTGQVED 734
L + KS E E Q+L Q+ EFS Q +KE + + T Q+E+
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM- 793
L+ +L+ EI K+ L + L + + + + QR+L + + A
Sbjct: 1321 LKRQLE---EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 794 ---HHSFANIIGEQGSMPSERSECRLEADQS------------PKNSAILQNRVDSLEFS 838
+ + A E+ ++ RL+A + K LQN V+ L
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
+E + L K+ +I E ++ K E+ H A + S L + +N
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQ---KCEETHAELEASQKEARS-LGTELFKIKNA 1493
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
E+L LE ++E + L ++ +I E K H EL+ + + + EK E+
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH-------ELEKIKKQVEQEKCEL 1546
Query: 959 SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
+ + + +E E G + I LNQ K + +K I E+++ I DQ
Sbjct: 1547 QAALEEAEASLE---HEEGKILRIQLELNQVKSEVDRK-------IAEKDEEI----DQL 1592
Query: 1019 KQEKLILLQRCEETGNA----YEDLSQKYKAAQEKNSKLECLLNECTSLC----ENRKNE 1070
K+ + +++ + T +A D + K + +++E LN + N +N
Sbjct: 1593 KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT 1652
Query: 1071 LEQLKEA------FAKEHQEFLTKLAFAEERNQNLMLELE----TVQQALRS------EM 1114
LK+ + ++ +LA E R L E+E T++Q RS E+
Sbjct: 1653 QGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Query: 1115 TDNQNNSK---SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
D + ++ L L+ + ++MQ E+ D+LQE + K + +
Sbjct: 1713 LDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
Query: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
E ++ KE+++ + K M+ VK++ L A+ +L L+ +K+
Sbjct: 1773 EELK---KEQDTSAHLERMKKNMEQTVKDLQLRLDEAE-----------QLALKGGKKQI 1818
Query: 1232 ECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC 1291
+ L+ ++ + G++E+ Q ++ + GL+ K+ EL+ ++
Sbjct: 1819 QKLEARVRELEGEVESE--QKRNAEAVKGLR--------KHERRVKELTYQTEEDRKNIL 1868
Query: 1292 SLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL-NEVKILN 1350
LQ ++KL K + QAE+ E + N ++ + + AEE + ++V L
Sbjct: 1869 RLQDLVDKLQAKVKSYK-RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Query: 1351 DDSGLLHGELVED 1363
S +H +++ +
Sbjct: 1928 VKSREVHTKVISE 1940
Score = 129 bits (325), Expect = 3e-29
Identities = 229/1164 (19%), Positives = 469/1164 (40%), Gaps = 130/1164 (11%)
Query: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
KL + L K + +++ +E +++ D+L+K+E + K L + KE +L+
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEE-FQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
+ + ++ E+ Q+ K L++KI + + ++ + E + R LE +
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 675 LSVEIRNLHNV------------------------LDSKSVEVETQKLAYMELQQKAEFS 710
L +I +L LD ++ +K A E Q+
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Q + ++ + +L QV+DLE L+ MD +R + L + LK
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-------LKLA 1068
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
S++ E+ ++ L + F E ++ S+ + + Q K LQ
Sbjct: 1069 QESIMDIENEKQQL----DEKLKKKEF-----EISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE-------QMHQSFVAETSQ 883
R++ LE +E+++ + +KQ +L + EI E L +A +M++ AE +
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 884 RISKLQEDTSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
L+E T H+ T + L K + + L ++++ Q Q+L+K ++ +
Sbjct: 1180 MRRDLEEATLQHE----ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
+L ET+S K + + + ++ EL + + + L ++ L +S F+
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
+DE+E +S+LS + K Q+ EE L ++ KA L+ ++C
Sbjct: 1296 QLDEKEALVSQLS----RGKQAFTQQIEE---LKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 1063 LCENRKNELE---QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
L E + E E +L+ A +K + E + + + + E +++A + ++
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEV---AQWRTKYETDAIQRTEELEEA-KKKLAQRLQ 1404
Query: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
++ + + +L++ + ++Q EV DL ++ V +T C L+ + RN K
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDL------MLDVERTNAACAALDKKQ-RNFDK 1457
Query: 1180 ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL- 1238
+ +C + +LE + S +L +++ +L+ ++E + LQ E+
Sbjct: 1458 ILAEWKQKCE-ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 1239 ----QTIRGDLETSNLQDMQSQEISGLKDCEIDA--EEKYISGPHELSTSQNDNAHLQCS 1292
Q G L+ ++ Q + CE+ A EE S HE L
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQ--EKCELQAALEEAEASLEHEEGKILRIQLELNQV 1574
Query: 1293 LQTTMNKLNELEKICEILQAEKYELVTELND-------SRSECITATRKMAEEVGKLLNE 1345
K+ E ++ + L+ +V + SR++ I +KM + LNE
Sbjct: 1575 KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD----LNE 1630
Query: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFA 1405
++I + + + E + + + G + Q + A + + E L + ++ + A
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQ-GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 1406 ELQEKFLSLQS---EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK 1462
E++E +L+ KI + S ++ L T SL L T++ QG++
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED 1749
Query: 1463 EMQLGLEEGLVPSLSSSCVPDSSSLS-SLGDSSFYRALLEQTGDMSLLSNLEGAVSANQC 1521
+Q E + + D++ ++ L A LE+ + N+E V Q
Sbjct: 1750 ILQ---EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-----MKKNMEQTVKDLQL 1801
Query: 1522 SVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI--MKNK 1579
+DE E L K K +++LE+ +E E+K ++ + ++
Sbjct: 1802 RLDEA-------EQLALK----GGKKQIQKLEARVRELEGEVES-EQKRNAEAVKGLRKH 1849
Query: 1580 EIQELEQLLSSERQELDCLRKQYLSENEQ-----WQQKLTSVTLEMESKLAAEKK---QT 1631
E + E +E + LR Q L + Q ++++ + + LA +K +
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 1632 EQLSLELEVARLQLQGLDLSSRSL 1655
E+ ++A Q+ L + SR +
Sbjct: 1910 EEAEERADIAESQVNKLRVKSREV 1933
Score = 126 bits (316), Expect = 4e-28
Identities = 237/1203 (19%), Positives = 490/1203 (40%), Gaps = 162/1203 (13%)
Query: 1222 LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELST 1281
LK E+EKE ++ E Q I+ +L S + + EEK ++ L
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKE-------------LEEKMVT----LLK 888
Query: 1282 SQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341
+ND LQ +Q L + E+ C+ L K +L ++ + +T + EE+
Sbjct: 889 EKND---LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKE-----VTERAEDEEEINA 940
Query: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD-KEV 1400
L K +D EL +DI E ++LA +++ +H T + K +
Sbjct: 941 ELTAKKRKLEDEC---SELKKDIDDLE----------LTLAKVEKE---KHATENKVKNL 984
Query: 1401 QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
A L E L E K L + H Q + + V++L + L + + +G L
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ 1520
+E +L ++ RA + GD+ L + +
Sbjct: 1045 EQEKKLRMD-------------------------LERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 1521 CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580
+DE E + + + A G++ + + E+ + +E+LEE++E++ + K
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR-IEELEEEIEAERASRAK- 1137
Query: 1581 IQELEQLLSSERQELDCLRK-QYLSENEQWQQKLTSVTLEMESKLAAE----KKQTEQLS 1635
+E+Q D R+ + +SE + TS +EM K AE ++ E+ +
Sbjct: 1138 ---------AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 1636 LELEVARLQLQGLDLSSRSLLG--IDTEDAIQGRNES------CDISKEHTSETTERTPK 1687
L+ E L+ S + LG ID ++ + E +I ++ T K
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 1688 HDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECIS 1747
++ ++C Q L ++ + + G ++ D+ + +S
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA---LVS 1305
Query: 1748 ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE- 1806
+LS G A + I L+ +++E L H ++ + L + +E
Sbjct: 1306 QLS-RGKQAFT--------QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 1807 LDSKLHLQEV---------QLMTKIE--ACIELEKIVGELKKENSDLSEKLEYFSCDHQE 1855
+SK LQ Q TK E A E++ KK L E+ + +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 1856 LLQRVETSEGLNSDLE--------MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRI 1907
+T + L +++E +A ++ + N K+ WK++ + EL
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
+ E S+ E ++ E + L+++N+N Q+ I L E+++ E + EL
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA----EGGKRIHEL 1532
Query: 1968 DTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL-LQTLSSDVSE 2025
+ + K+ +L ++E LE + + L IQ+ +VK + + + ++ +
Sbjct: 1533 EKIKKQVEQEKCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 2026 LLKDKTHLQEKLQS-----LEKDSQALSLTKC------ELENQIAQLNKEKELLVKESES 2074
L ++ + E +QS + + A+ L K E+E Q+ N+ ++ +
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFAL---RLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Q L ++ ++++ AL + K + A+ R + Q E+ +LR +E+ +
Sbjct: 1652 TQGILKDT---QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
E++ L +E+++ +N SL + + LE ++ + E ++ +A N++ + + T
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
MA LK + L K+N+ + +++ Q +L E ++L + K ++ ++ E +++
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVR 1826
Query: 2252 E-ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARL 2310
E E + E +N EAV L + +K + + +L++ ++KL+A++
Sbjct: 1827 ELEGEVESEQKRNA-----EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLK 2370
++ ++ Q +E+E ++ + L+ ELE A + A + + + +
Sbjct: 1882 KSYKR-------QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1934
Query: 2371 AKI 2373
K+
Sbjct: 1935 TKV 1937
Score = 123 bits (308), Expect = 3e-27
Identities = 237/1245 (19%), Positives = 496/1245 (39%), Gaps = 215/1245 (17%)
Query: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
EE ++L++ +E K+ LL E KN+L+ +A A+ L
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKE--------KNDLQLQVQAEAEG-------L 904
Query: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
A AEER L ++ + +A E+T+ + + L + L++E ++++K+++DL
Sbjct: 905 ADAEERCDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 963
Query: 1150 LQENEQLMKVMKTKHECQNLES----------EPIRNSVKERESERNQCNFKPQMDLEVK 1199
L KV K KH +N E I KE+++ + + + + DL+ +
Sbjct: 964 ---ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ-EAHQQTLDDLQAE 1019
Query: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
E +++ ++LE + + E L++ +K + L+ + + GDL+ + M +
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 1260 GLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
D ++ +E IS ++ Q LQ ++ ++ ELE+ E +A + +
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 1319 TELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
+ +D E + ++ E G +++ +N ++ D+ E+ QH
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIE-MNKKREAEFQKMRRDL------EEATLQHE 1192
Query: 1379 VSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTY 1438
+ A L + ++ AEL E+ +LQ + L + +M ++ +L +
Sbjct: 1193 ATAATLRKKHADS------------VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498
V+++ L R + D + E++ EE R
Sbjct: 1241 VETVSKAKGNLEKMCRTLE-DQLSELKSKEEEQ------------------------QRL 1275
Query: 1499 LLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV 1558
+ + T L G S L KE V +L +
Sbjct: 1276 INDLTAQRGRLQTESGEFS----------------RQLDEKEAL------VSQLSRGKQA 1313
Query: 1559 YRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE---QWQQKLTS 1615
+ Q +E+L+ ++E + KN L L S R + D LR+QY E E + Q+ L+
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNA----LAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQL-QGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
E+ + Q + ELE A+ +L Q L + E+ ++ N C
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA---------EEHVEAVNAKCA-- 1418
Query: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734
+ E T++ +++V +DL LD+E+ C+ N++
Sbjct: 1419 ---SLEKTKQRLQNEV---------EDLMLDVERTNAA--------CAALDKKQRNFDKI 1458
Query: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKET-SNENLRLLHVIEDR 1793
+ Q E +EL S A L ++ + L ET EN L I D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 1794 DRKVES---LLNEMKELDSKLHLQEVQLMTKIEAC---------------IELEKIVGEL 1835
++ ++E++++ ++ ++ +L +E +EL ++ E+
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
++ ++ E+++ +H +++ ++++ + A+ SR D K+ E
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQST--------LDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 1896 RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV 1955
+ + N +R+ +E + D ++ + L ++D L+E+L++
Sbjct: 1631 MEIQL-NHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED----------LKEQLAM 1679
Query: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL--ESHQSECLHCIQVAEAEVKEKT 2013
V N L+ E++ + L+Q K QEL S + + LH + K+K
Sbjct: 1680 VERRANLLQAEIEELR---ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 2014 EL-LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072
E + + ++ ++L++ + +EK + D+ ++ + ++ A L + K+ + +
Sbjct: 1737 ETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1796
Query: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
+ LQ RL E++ L L ++++ +L + +L +E+++
Sbjct: 1797 KDLQLRLDEAEQ--------------------LALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 2133 KKQLHIAEKLKERER---------ENDS-----LKDKVENLERELQMSEENQELVILDAE 2178
K+ + L++ ER E D L+D V+ L+ +++ + E +
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Query: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLR-SEKENLTKQIQEK 2222
+ A+ L+ ++EE + E + LR +E TK I E+
Sbjct: 1897 TNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 183 bits (465), Expect = 2e-45
Identities = 245/1174 (20%), Positives = 523/1174 (44%), Gaps = 150/1174 (12%)
Query: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
++++ N++ ++T E + ++ + K+ +L+ E +L ++Q+ + ++
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-------QLQVQAEADSL 902
Query: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
+ E+ +L K L K++ E+ +R E E +N++L A K ED
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIK-------EVTERAEDEEEINAELT--AKKRKLEDECSE 953
Query: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
+ K D D+E L+++ EK + E++ L ++ + L K+ + Q+
Sbjct: 954 LKKDID-------DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1006
Query: 1946 IVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
++ L + +E +++ +T++K L+Q + ++ ++ + + + +
Sbjct: 1007 H---QQTLDDLQAEEDKV----NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL 1059
Query: 2006 EAEVKEKTELLQTLSSD---VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062
E ++K E + +D + E LK K LQS +D QAL + +L+ +I +L
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM---QLQKKIKELQ 1116
Query: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
E L +E E+ +A ++++ ++ ++S+ LE + E+ E A +S Q E+++ +R E
Sbjct: 1117 ARIEELEEEIEAERASRAKAEKQRSDLSRELE-EISERLEEAGGATSAQIEMNK-KREAE 1174
Query: 2123 KLRVRIEADEKKQLHIAEKLKERERENDS---LKDKVENLERELQMSEENQELVILDAEN 2179
++R + +E H A R++ DS L ++++NL+R Q E+ + + ++ ++
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 2180 SKAEVET---------------------LKTQIEEMARSLKVFELDLVTLRSEKENLTKQ 2218
+ +ET +KT+ EE R + L++E ++Q
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 2219 IQEKQGQLSELDKLLSSFKSLLEE-KEQAEIQIKEESKTA---------VEMLQNQLKEL 2268
+ EK +S+L + +F +EE K Q E +IK +S A ++L+ Q +E
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354
Query: 2269 NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328
EA A L + + KA + + E E+L + KK+L Q+L+++E
Sbjct: 1355 QEAKAEL--QRAMSKANSEVAQWRTKYETDAIQRTEELE-----EAKKKLA--QRLQDAE 1405
Query: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
H + + + +LE+ + + E ++ E + L K + L +
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 2389 TIRSEKENLTNELQKEQERIS-ELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
+E E QKE +S EL I +++E L + E K + K LQ ++
Sbjct: 1466 ETHAELE----ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN--------LQQEI 1513
Query: 2448 KELNERVA----ALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503
+L E++A +H ++ K EQ S LE +A L+ + + +Q +
Sbjct: 1514 SDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEA----SLEHEEGKILRIQLEL 1569
Query: 2504 NGLIQEVEDGKQKLEKKDEEISRLK-NQIQDQEQLVSKL-SQVEGEH---QLWKEQNLEL 2558
N + EV+ +K+ +KDEEI ++K N I+ E + S L +++ + +L K+ +L
Sbjct: 1570 NQVKSEVD---RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1626
Query: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTK--MDKMSFVEKVNKMTA 2616
+ ++L ++ + ++T +L+ + +L++ L + ++++ VE+ +
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 2617 KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKK 2676
E E R E +++ ++ E+ E + +QLL + S + K+L + S+++
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQ---ELLDASERVQLLHTQNTSLINTKKKLETDISQIQG 1743
Query: 2677 SLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH--QALLLDTNKQYEVEIQTYREKLTS 2734
++ + ++ E K ++ I + + E +K+ A L K E ++ + +L
Sbjct: 1744 EMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Query: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGK 2794
E+ LK K+++ ++ E++ + N++ V L+K +
Sbjct: 1804 AEQL---------ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKV--- 1851
Query: 2795 MKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKT 2854
K+L + E +K + +LQ VD+L ++K K EE
Sbjct: 1852 --------KELTYQTEEDRKNILRLQ-------------DLVDKLQAKVKSYKRQAEEAE 1890
Query: 2855 KEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
++++ L K+ + E+ E+ ++ E+QV L
Sbjct: 1891 EQSNVNLSKFRRIQHELEEAEERADIAESQVNKL 1924
Score = 163 bits (412), Expect = 3e-39
Identities = 222/1040 (21%), Positives = 449/1040 (43%), Gaps = 130/1040 (12%)
Query: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
EK+ N ++ +EEL+ ++R +L ++ T+ ++ L + + + E
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
+ + EA++KE TE + +EL K L+++ L+KD L LT ++E
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 2056 NQ---------------------IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
+ IA+L KEK+ L E+ Q L + E+ V+ L
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL---QEAHQQTLDDLQAEEDKVN-TLT 1025
Query: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD-----------EKKQLHIAEKLK 2143
A ++ + L + E+ ++R +E+ + ++E D E + + EKLK
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 2144 ERERENDSLKDKVENLER-ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
++E E L+ K+E+ + +Q+ ++ +EL +A +E L+ +IE S E
Sbjct: 1086 KKEFEMSGLQSKIEDEQALGMQLQKKIKEL--------QARIEELEEEIEAERASRAKAE 1137
Query: 2203 LDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLEEKEQAEIQ-------IK 2251
L E E ++++++E G Q+ K + F+ + + E+A +Q ++
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 2252 EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
++ +V L Q+ L L ++ MK L +E + + ++EK+ LE
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Query: 2312 ADEKKQLCVLQQLKESEHHA--DLLKGRVENLERELEIARTNQEHAALEAENSKG----- 2364
QL ++ +E + DL R E +R E L ++ S+G
Sbjct: 1258 ----DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT 1313
Query: 2365 -EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE----IINSSFE 2419
++E LK ++E ++ L + + R + + L + ++EQE +EL+ NS
Sbjct: 1314 QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373
Query: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
+ E + +Q E+ A + L +L++ E V A++ + + +Q L ++VE L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433
Query: 2480 LEKAQ---LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI----Q 2532
++ + LD+ + N+ + + Q+ E+ +LE +E L ++
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWK---QKCEETHAELEASQKESRSLSTELFKIKN 1490
Query: 2533 DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
E+ + +L ++ E++ +++ +L E ++I L+ ++ LQ++ +
Sbjct: 1491 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550
Query: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKN---RLAGE 2649
E LE + K+ + EL + E+ +K AE EE+ K R+
Sbjct: 1551 AEASLE----------HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVES 1600
Query: 2650 LQLLLE-EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
+Q L+ EI+S D ++ LKK ++ +++E + +A LR + +
Sbjct: 1601 MQSTLDAEIRSRNDAIR--------LKKKME-GDLNEMEIQLNHANRMAAEALRNY---R 1648
Query: 2709 KHQALLLDTNKQYEVEIQT---YREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
QA+L DT + +++ +E+L E + + EI+ L+++ E+ S K Q
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 2766 IL----EELKKTKMDNLKYVNQLKK---ENERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2818
L E ++ N +N KK + + QG+M+ +I+ + EE+ +K ++
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEK---AKKAITD 1765
Query: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
E+ K K + + ++ +K+ LE+ K+ LD+ L + K K
Sbjct: 1766 AAMMAEELK-------KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQI 1816
Query: 2879 EMLETQVAHLCSQQSKQDSR 2898
+ LE +V L + + R
Sbjct: 1817 QKLEARVRELEGEVESEQKR 1836
Score = 149 bits (375), Expect = 6e-35
Identities = 223/1132 (19%), Positives = 478/1132 (42%), Gaps = 142/1132 (12%)
Query: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDS----------------- 43
M E+ KE L + K +ELE ++ L +EK Q Q+ +
Sbjct: 856 MKEEFEKTKEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIK 914
Query: 44 ----LEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNF 99
LEA +++ ++ E+E+ L + ++L + C L+K + L E + +
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 100 QEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYY 159
E ++ + +++ L++ + + E + Q+A Q +L+ + T LT ++
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ---TLDDLQAEEDKVNT-LTKAKIK 1030
Query: 160 SGSKYEDLKEKYNKEVEERKRLEAEVKALQAK-KASQTLPQATMNHRDIARHQASSSVF- 217
+ +DL+ +E + R LE + L+ K +Q N + + F
Sbjct: 1031 LEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFE 1090
Query: 218 -SWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD---- 272
S Q K + Q ++ A E+E+ R++ ++ + +
Sbjct: 1091 MSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 273 ----------NSSSPHLLDQLKAQNQELRNKINELELRLQG-----------HEKEMKGQ 311
S+ + + +A+ Q++R + E L+ + E+ Q
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1210
Query: 312 VNKFQELQLQLEKAKVE-------LIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
++ Q ++ +LEK K E L + ++K + L + + ++ E++
Sbjct: 1211 IDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQ 1270
Query: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
++L DL+ QR ++ +++ EK+ +LSR +++F Q+ ++K +L +E
Sbjct: 1271 QRLINDLTAQRARLQTESGEYSRQLDEKD-TLVSQLSRGKQAF---TQQIEELKRQLEEE 1326
Query: 425 LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEM 484
++ + + LQ+ +++Q E +E K +L RA + ++ E+
Sbjct: 1327 IKAKSALAHALQSSRHDCDLLREQYEEE-QEAKAELQRA-------------MSKANSEV 1372
Query: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
+ ++ + Q+ E LE K + Q L ++ E + AK S E + LQ ++
Sbjct: 1373 AQWRTKYETDAIQRTEE---LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL 604
++ + +E+ A A L+K++ +L + + E+ + +L ++KES++L + L
Sbjct: 1430 --EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 605 KKKEYEE-LKEEKTLFSCWKSENEKLLTQMESEKENLQ---SKINHLETCLKTQQIKSHE 660
K YEE L + +TL K EN+ L ++ E + +I+ LE K + + E
Sbjct: 1488 IKNAYEESLDQLETL----KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 661 YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
+ E E+ +I + L+ EV+ ++ +K E DQ + I
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVD------RKIAEKDEEIDQMKRNHIRI 1597
Query: 721 MCLKTSQLTGQV----------EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
+ S L ++ + +E L + ++ +R + Y + + +LK
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
L +D RS +Q AM AN+ + +E E R +Q+ ++ I +
Sbjct: 1658 QLHL---DDALRSQEDLKEQLAMVERRANL------LQAEIEELRATLEQTERSRKIAEQ 1708
Query: 831 RVDSLEFSLESQKQMNSDL---QKQCE-ELVQIKGEIEENLMK---AEQMHQSFVAETSQ 883
+ ++ N+ L +K+ E ++ QI+GE+E+ + + AE+ + + + +
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 884 RISKL--QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
+L ++DTSAH + + LE K+LQ D E EQ ++ KK LE +
Sbjct: 1769 MAEELKKEQDTSAHLERMKKN---LEQTVKDLQHRLD--EAEQLALKGGKKQIQKLEARV 1823
Query: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
+EL+ E S +K+ + ++ L K E + +KE+ +++ N++ + +
Sbjct: 1824 RELE--GEVESEQKRNVEAVKGLRKHERK--------VKELTYQTEEDRKNIL-RLQDLV 1872
Query: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
+ + + KS +++ +++ + L + + E+ ++ A+ + +KL
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL 1924
Score = 147 bits (372), Expect = 1e-34
Identities = 214/1064 (20%), Positives = 437/1064 (41%), Gaps = 144/1064 (13%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
E +E + K ++LE + +LKK+ + L +E + KV+N E L
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQ 116
+L + ++L++ Q+ +LQ +E +VN Q L +Q +K+
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRM 1050
Query: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG--SKYEDLK------ 168
+L+R K +LE + AQ + + + N Q++ SG SK ED +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDIE--NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQL 1108
Query: 169 EKYNKEVEER-KRLEAEVKALQAKKASQTLPQATMNHRDIARH-QASSSVFSWQQEKTPS 226
+K KE++ R + LE E++A +A +A +A D++R + S T +
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRA-----KAEKQRSDLSRELEEISERLEEAGGATSA 1163
Query: 227 HLSSNSQRTP----IRRDFSASYFSGEQEVTPSR-----STLQIGKRDANSSFFDNSSSP 277
+ N +R +RRD + E R S ++G++ N
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ-------- 1215
Query: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKF-QELQLQLEKAKVELIEKEKVL 336
+ +L+ + E++ +I++L ++ K KG + K + L+ QL + K + E+++++
Sbjct: 1216 RVKQKLEKEKSEMKMEIDDLASNMETVSKA-KGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Query: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK------ 390
N + R + + S + + + +L+ Q E + LE++IK
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334
Query: 391 -----------------EKEKEFQEELSR----------QQRSFQTLD-----QECIQMK 418
E+E+E + EL R Q R+ D +E + K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
+L Q LQ A+ + A+ L KQ+L+N +E+ + R A A K+
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
+ + E K++ + E +E L EL IK +S + E +K +N + + +
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 539 DLQEKINQQENSL-TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
DL E+I + + LEK+K V E+++ Q L++ E +E K+ + + E
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQV---EQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
+ S ++ K E +E ++ K + +++ M+S L ++I ++ ++
Sbjct: 1572 VKSEVDRKIAEKDEEIDQ------MKRNHIRIVESMQS---TLDAEIRSRNDAIRLKKKM 1622
Query: 658 SHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
+ NE L + +RN N ++++ +TQ L+ + + +Q E
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRNYRN---TQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679
Query: 718 IENMCLKT--SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
L+ +L +E E ++ E++D Q LH + SL + K + +
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI- 1738
Query: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
+ I GE + E +A ++ ++A++
Sbjct: 1739 ----------------------SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAE----- 1771
Query: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM----HQSFVAETSQRISKLQED 891
L+ ++ ++ L++ + L Q +++ L +AEQ+ + + + R+ +L+ +
Sbjct: 1772 --ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1829
Query: 892 TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL 951
+ Q E + L E++++ L + E ++ I L+ L+ +K + +E
Sbjct: 1830 VESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-- 1887
Query: 952 SLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
E +E S++ R I+ +E E A + + ++N ++
Sbjct: 1888 --EAEEQSNVNLSKFRRIQHELEE----AEERADIAESQVNKLR 1925
Score = 145 bits (365), Expect = 8e-34
Identities = 246/1159 (21%), Positives = 474/1159 (40%), Gaps = 185/1159 (15%)
Query: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE-LDKLTSVKQQLENNL 453
E+Q+ + R++ F CIQ R ++ M + + L K ++++ N
Sbjct: 804 EYQKMVERRESIF------CIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMK 857
Query: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK------SHSEQKAREVC---- 503
EEF+ + ++ ++ K EL M + +E N L+ + S A E C
Sbjct: 858 EEFE----KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLI 913
Query: 504 ----HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA 559
LEA++K + + + E+ AK E +L++ I + L+L
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI---------DDLELT 964
Query: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLF 619
+A +EK++ +++ +K + L++ ++K KE KAL E ++ ++L+ E
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL---QEAHQQTLDDLQAE---- 1017
Query: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
E + + K L+ +++ LE L E+ + + MD E ++
Sbjct: 1018 -------EDKVNTLTKAKIKLEQQVDDLEGSL-----------EQEKKIRMDLERAKRKL 1059
Query: 680 RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+ ++++E K E +K EF Q +IE+ QL ++++L+ ++
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 740 QLLSNEI-------MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 792
+ L EI ++ DL E E + + L+ + + + A
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA------ 1173
Query: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
E M + E L+ + + + + + DS+ ++L +Q
Sbjct: 1174 ----------EFQKMRRDLEEATLQHEATA--ATLRKKHADSV-----------AELGEQ 1210
Query: 853 CEELVQIKGEIEENLMKAE-QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
+ L ++K ++E+ K+E +M +A + +SK + + + + LS ++ KE+
Sbjct: 1211 IDNLQRVKQKLEKE--KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 912 ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEE 971
E Q L + + ++A +Q + L E L LS K+ + I KR++EE
Sbjct: 1269 EQQRLINDLTAQRARLQ---TESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 972 LTQENGTLKEINASLNQE----KMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
+ L S + + ++ E+ A K+ SE++ + + +Q
Sbjct: 1326 EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQ 1385
Query: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR---KNELEQLK--------- 1075
R EE A + L+Q+ + A+E +E + +C SL + + +NE+E L
Sbjct: 1386 RTEELEEAKKKLAQRLQDAEE---HVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAA 1442
Query: 1076 -EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
A K+ + F LA +++ + ELE Q+ RS T+ + L Q + T
Sbjct: 1443 CAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ-LET 1501
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM 1194
LK E +Q+E++DL EQ+ + K HE E I+ V++ +SE Q
Sbjct: 1502 LKRENKNLQQEISDL---TEQIAEGGKRIHEL-----EKIKKQVEQEKSEL-------QA 1546
Query: 1195 DLEVKEISLDSYNAQL--VQLEAMLRNKELKLQESEKEKECLQHELQTIR---------- 1242
LE E SL+ ++ +QLE E+ + +EK++E Q + IR
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606
Query: 1243 GDLETSNLQDMQSQEISG-LKDCEIDAEEKYISGPHELSTSQNDNA-------HLQCSLQ 1294
++ + N +++ G L + EI L +N A HL +L+
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 1295 T---TMNKLNELEKICEILQAEKYELVTELND-------SRSECITATRK---MAEEVGK 1341
+ +L +E+ +LQAE EL L + E + A+ + + +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL-----DESNSYEHLTLS 1396
L+N K L D + GE+ + I E+ ++ A + E ++ HL
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 1397 DKEVQMHFAELQEKF-----LSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
K ++ +LQ + L+L+ K Q ++ +++ EL+ V+S + N+
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKK----QIQKLEARVRELEGEVESEQKRNVEAVK 1842
Query: 1452 NLRNFQGDLVKEMQLGLEE 1470
LR + VKE+ EE
Sbjct: 1843 GLRKHERK-VKELTYQTEE 1860
Score = 144 bits (362), Expect = 2e-33
Identities = 212/981 (21%), Positives = 424/981 (43%), Gaps = 155/981 (15%)
Query: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
EK +Q ++ T+ +A++ +K +V+ ES+ + + +NV L K
Sbjct: 783 EKLAQLITRTQAMCRGFLARVEYQK--MVERRESIFC-IQYNVRAFMNVKHWPWMKLYFK 839
Query: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL-----------KEREREN 2149
+ L+ + T++E+ ++ EK + + E K+ + EK+ + + E
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA 899
Query: 2150 DSLKDKVEN----LERELQMSEENQELV--ILDAENSKAEVETLKTQIEEMARSLK--VF 2201
DSL D E ++ ++Q+ + +E+ D E AE+ K ++E+ LK +
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 2202 ELDLVTLRSEK-----ENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ----------- 2245
+L+L + EK EN K + E+ L E L+ K L+E Q
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 2246 -------AEIQIKEESKTAVEMLQNQLK---ELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
A+I+++++ L+ + K +L A L GD ++ + + ++ +
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE---ND 1076
Query: 2296 EHQLRNSIEK-------LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348
+ QL ++K L++++E ++ + + +++KE L+ R+E LE E+E
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE-------LQARIEELEEEIEAE 1129
Query: 2349 RTNQEHAALEAENSKGEVETLKAKIE---GMTQSL----RGLELDVVTIRSEKENLTNE- 2400
R ++ A + + E+E + ++E G T + + E + +R + E T +
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 2401 -------LQKEQERISELEIINSSFENILQEKEQEKVQMK---EKSSTAMEMLQTQLKEL 2450
+K + ++EL + + + Q+ E+EK +MK + ++ ME + L
Sbjct: 1190 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNL 1249
Query: 2451 NERVAALHNDQEACKAKEQ-------NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503
+ AL + K KE+ +L++Q L+ E + + LDE L
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQ---------------DQE---QLVSKLSQVE 2545
Q++E+ K++LE++ + S L + +Q +QE +L +S+
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 2546 GEHQLWK--------EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
E W+ ++ EL +L Q++Q + ++ L+ + + L+NE+
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 2598 ELTKMDKMSFVEKVNKMTA----KETELQREMHEMAQKTAELQEELSG---EKNRLAGEL 2650
E D M VE+ N A K+ + + E QK E EL E L+ EL
Sbjct: 1430 E----DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485
Query: 2651 QLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKH 2710
+ + S DQL+ L EN L++ + + +Q+ + GK E+ + + ++ + + +
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDL-TEQIAEGGKRIHELEKIKKQVEQEKSEL 1544
Query: 2711 QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK-EELNNSLKATTQILEE 2769
QA L ++ E ++ K+ + L+ K E+D + K EE++ + +I+E
Sbjct: 1545 QAAL----EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVES 1600
Query: 2770 LKKTKMDNLKYVN---QLKKENERAQGKMKLLIKSCKQLEEE--------KEIL---QKE 2815
++ T ++ N +LKK+ E +M++ + ++ E + IL Q
Sbjct: 1601 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 2816 LSQLQAAQEKQKTGTVM-DTKVDELTTEIKELKETLEEKTKE----ADEYLDKYCSLLIS 2870
L +QE K M + + + L EI+EL+ TLE+ + E LD + +
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1720
Query: 2871 HEK---LEKAKEMLETQVAHL 2888
H + L K+ LET ++ +
Sbjct: 1721 HTQNTSLINTKKKLETDISQI 1741
Score = 138 bits (348), Expect = 7e-32
Identities = 242/1178 (20%), Positives = 482/1178 (40%), Gaps = 132/1178 (11%)
Query: 513 KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
K+ N + F E+ K + E ++L+EK+ +TL + K DL+ Q D
Sbjct: 851 KEMANMKEEF-EKTKEELAKTEAKRKELEEKM------VTLMQEK---NDLQLQVQAEAD 900
Query: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632
L E D+L KT+ + +A + + + ++ EE+ E T ++ KL
Sbjct: 901 SLADAEERC----DQLIKTKIQLEAKIKEVTERAEDEEEINAELT------AKKRKL--- 947
Query: 633 MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVE 692
E E L+ I+ LE L + + H +V+ NL+ E+ LD +
Sbjct: 948 -EDECSELKKDIDDLELTLAKVEKEKHATENKVK-------NLTEEMAG----LDETIAK 995
Query: 693 VETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
+ +K A E Q+ Q + ++ + +L QV+DLE L+ MD +R
Sbjct: 996 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA 1055
Query: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
+ L DL ++++++ D Q+ + E + S+
Sbjct: 1056 KRKLEG------DLKLAQESTMDIENDKQQ----------LDEKLKKKEFEMSGLQSKIE 1099
Query: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE- 871
+ + Q K LQ R++ LE +E+++ + +KQ +L + EI E L +A
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159
Query: 872 ------QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE-LQLLNDKVETEQ 924
+M++ AE + L+E T H+ T + L K + + L ++++ Q
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHE----ATAATLRKKHADSVAELGEQIDNLQ 1215
Query: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Q+L+K ++ + +L ET+S K + + + ++ E+ + + +
Sbjct: 1216 RVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN 1275
Query: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044
L ++ L +S ++ +DE++ +S+LS + K Q+ EE L ++ K
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLS----RGKQAFTQQIEE---LKRQLEEEIK 1328
Query: 1045 AAQEKNSKLECLLNECTSLCENRKNELE---QLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
A L+ ++C L E + E E +L+ A +K + E E
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK 1161
ELE ++ L + D + + ++ + + +L++ + ++Q EV DL ++ V +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEA----VNAKCASLEKTKQRLQNEVEDL------MIDVER 1438
Query: 1162 TKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE 1221
T C L+ + RN K + +C + +LE + S + +L +++
Sbjct: 1439 TNAACAALDKKQ-RNFDKILAEWKQKCE-ETHAELEASQKESRSLSTELFKIKNAYEESL 1496
Query: 1222 LKLQESEKEKECLQHEL-----QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
+L+ ++E + LQ E+ Q G L+ ++ Q + + EE S
Sbjct: 1497 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 1556
Query: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND-------SRSECI 1329
HE L K+ E ++ + ++ +V + SR++ I
Sbjct: 1557 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616
Query: 1330 TATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNS 1389
+KM + LNE++I + + + E + + + + + H + A + +
Sbjct: 1617 RLKKKMEGD----LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH-LDDALRSQEDL 1671
Query: 1390 YEHLTLSDKEVQMHFAELQEKFLSLQS---EHKILHDQHCQMSSKMSELQTYVDSLKAEN 1446
E L + ++ + AE++E +L+ KI + S ++ L T SL
Sbjct: 1672 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 1447 LVLSTNLRNFQG---DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQT 1503
L T++ QG D+++E + EE +++ + + + L D+S A LE+
Sbjct: 1732 KKLETDISQIQGEMEDIIQEAR-NAEEKAKKAITDAAMM-AEELKKEQDTS---AHLER- 1785
Query: 1504 GDMSLLSNLEGAVSANQCSVDEVFCSSLQ--EENLTRKETPSAPAKGVEELESLCEVYR- 1560
+ NLE V Q +DE +L+ ++ + + E +G E E V
Sbjct: 1786 ----MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAV 1841
Query: 1561 QSLEKLEEKMES---QGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVT 1617
+ L K E K++ Q K I L+ L+ + ++ ++Q EQ ++V
Sbjct: 1842 KGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ-----SNVN 1896
Query: 1618 LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655
L ++ E ++ E+ ++A Q+ L + SR +
Sbjct: 1897 LSKFRRIQHELEEAEE---RADIAESQVNKLRVKSREV 1931
Score = 131 bits (329), Expect = 1e-29
Identities = 240/1204 (19%), Positives = 499/1204 (41%), Gaps = 164/1204 (13%)
Query: 1222 LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELST 1281
LK E+EKE ++ E + + +L + + + EEK ++ L
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKE-------------LEEKMVT----LMQ 886
Query: 1282 SQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341
+ND LQ +Q + L + E+ C+ L K +L ++ + +T + EE+
Sbjct: 887 EKND---LQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKE-----VTERAEDEEEINA 938
Query: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD-KEV 1400
L K +D EL +DI E ++LA +++ +H T + K +
Sbjct: 939 ELTAKKRKLEDEC---SELKKDIDDLE----------LTLAKVEKE---KHATENKVKNL 982
Query: 1401 QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
A L E L E K L + H Q + + V++L + L + + +G L
Sbjct: 983 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042
Query: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ 1520
+E ++ ++ RA + GD+ L + ++
Sbjct: 1043 EQEKKIRMD-------------------------LERAKRKLEGDLKLAQESTMDIENDK 1077
Query: 1521 CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580
+DE E + + + A G++ + + E+ + +E+LEE++E++ + K
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQAR-IEELEEEIEAERASRAK- 1135
Query: 1581 IQELEQLLSSERQELDCLRK-QYLSENEQWQQKLTSVTLEMESKLAAE----KKQTEQLS 1635
+E+Q D R+ + +SE + TS +EM K AE ++ E+ +
Sbjct: 1136 ---------AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 1636 LELEVARLQLQGLDLSSRSLLG--IDTEDAIQGRNES------CDISKEHTSETTERTPK 1687
L+ E L+ S + LG ID ++ + E +I ++ T K
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK 1246
Query: 1688 HDVHQICDKDAQQDLNLDIEKITETGAVKP-TGECSGEQSPDTNYEPPGEDKTQGSSECI 1746
++ ++C Q + ++ + + T + + Q+ Y ++K +
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK----DTLV 1302
Query: 1747 SELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKE 1806
S+LS G A + I L+ +++E L H ++ + L + +E
Sbjct: 1303 SQLS-RGKQAFT--------QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 1807 LD----------SKLHLQEVQLMTK-----IEACIELEKIVGELKKENSDLSEKLEYFSC 1851
SK + + Q TK I+ ELE+ +L + D E +E +
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 1413
Query: 1852 DHQEL---LQRVETS-EGLNSDLEM-HADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
L QR++ E L D+E +A ++ + N K+ WK++ + EL
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 1966
+ E S+ E ++ E + L+++N+N Q+ I L E+++ E + E
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA----EGGKRIHE 1529
Query: 1967 LDTMSKKTTA-LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL-LQTLSSDVS 2024
L+ + K+ +L ++E LE + + L IQ+ +VK + + + ++
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEID 1588
Query: 2025 ELLKDKTHLQEKLQS-----LEKDSQALSLTKC------ELENQIAQLNKEKELLVKESE 2073
++ ++ + E +QS + + A+ L K E+E Q+ N+ ++
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 2074 SLQARLSESDYEKLNVSKALEAALVEKGEFAL---RLSSTQEEVHQLRRGIEKLRVRIEA 2130
+ QA L ++ +L++ AL + K + A+ R + Q E+ +LR +E+ +
Sbjct: 1649 NTQAILKDT---QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1705
Query: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQ 2190
E++ L +E+++ +N SL + + LE ++ + E +I +A N++ + + T
Sbjct: 1706 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITD 1765
Query: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQI 2250
MA LK + L K+NL + +++ Q +L E ++L + K ++ ++ E ++
Sbjct: 1766 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLEARV 1823
Query: 2251 KE-ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
+E E + E +N EAV L + +K + + +L++ ++KL+A+
Sbjct: 1824 RELEGEVESEQKRNV-----EAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878
Query: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
+++ ++ Q +E+E +++ + ++ ELE A + A + + + +
Sbjct: 1879 VKSYKR-------QAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Query: 2370 KAKI 2373
KI
Sbjct: 1932 HTKI 1935
Score = 130 bits (327), Expect = 2e-29
Identities = 244/1192 (20%), Positives = 493/1192 (41%), Gaps = 177/1192 (14%)
Query: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE 342
+K + ++ + ++ + E + + E++M + + +LQLQ++ L + E+ +C D+
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE---RC-DQ 911
Query: 343 LVRTTAQYDQASTKYTALEQKLKKLTE----------DLSCQRQNAESARCSLEQKIKEK 392
L++T Q LE K+K++TE +L+ +++ E L++ I +
Sbjct: 912 LIKTKIQ----------LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 393 E---KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
E + ++E + + L +E + + + ++ K + Q LD L + + ++
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK----ENNLLKSHSEQKAREVCHL 505
N L + K KL + + S +E ++R +E K+ + L + + + L
Sbjct: 1022 -NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 506 EAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEK 565
+ +LK + ++ Q+ E+ +A + +++LQ +I + E + E+ A A EK
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA--EK 1138
Query: 566 QR-DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKS 624
QR D S++L E+++++L E+ A + +E+ KK E F +
Sbjct: 1139 QRSDLSREL--------EEISERL---EEAGGATSAQIEMNKKREAE-------FQKMRR 1180
Query: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
+ E+ Q E+ L+ K H ++ E E++ L+ ++ L E +
Sbjct: 1181 DLEEATLQHEATAATLRKK--HADSVA--------ELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 685 VLDSKSVEVETQKLAYMELQQ-----KAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKL 739
+D + +ET A L++ + + S+ K ++E + + + LT Q L+ +
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI--NDLTAQRARLQTES 1288
Query: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN 799
S ++ +KD L ++ ++ L E +S LA Q + H +
Sbjct: 1289 GEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL-EEEIKAKSALAHALQSSRHD--CD 1345
Query: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
++ EQ E ++ L+ S NS + Q R + +D ++ EEL +
Sbjct: 1346 LLREQYEEEQE-AKAELQRAMSKANSEVAQWRT-----------KYETDAIQRTEELEEA 1393
Query: 860 KGEIEENLMKAEQMHQSFVA------ETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
K ++ + L AE+ ++ A +T QR+ ED +AL+ K++
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1453
Query: 914 QLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973
DK+ E Q+ ++++ LE S KE S +LS E ++ K EE
Sbjct: 1454 ----DKILAEWK--QKCEETHAELEASQKE----SRSLSTELFKI-------KNAYEESL 1496
Query: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033
+ TLK N +L QE +L ++ I E EK + Q +QEK E
Sbjct: 1497 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK----IKKQVEQEK-------SELQ 1545
Query: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEH---QEFLTKLA 1090
A E+ + + K +++ LN+ S + + E ++ + + H E +
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
Query: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
AE R++N + L+ + +EM N++ A + + Q ++D L
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 1151 QENEQLMKVMKTKHECQNL---ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN 1207
+ E L + + NL E E +R ++++ E R + +D + L + N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE-QELLDASERVQLLHTQN 1724
Query: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNLQDMQSQEISGLKDCE 1265
L+ K+ L+ ++ I+G++E ++ + + + D
Sbjct: 1725 TSLI-----------------NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 1266 IDAEEKYISGPHELSTSQNDNAH-------LQCSLQTTMNKLNELEKIC--------EIL 1310
+ AE EL Q+ +AH L+ +++ ++L+E E++ + L
Sbjct: 1768 MMAE--------ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1819
Query: 1311 QAEKYELVTELNDSRS---ECITATRKMAEEVGKLLNEVKILNDDSGLLH-GELVEDIPG 1366
+A EL E+ + E + RK +V +L + + D +L +LV+ +
Sbjct: 1820 EARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTE--EDRKNILRLQDLVDKLQA 1877
Query: 1367 --GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQS 1416
+ Q E S L + +H L + E + AE Q L ++S
Sbjct: 1878 KVKSYKRQAEEAEEQSNVNLSKFRRIQH-ELEEAEERADIAESQVNKLRVKS 1928
Score = 128 bits (321), Expect = 1e-28
Identities = 248/1239 (20%), Positives = 503/1239 (40%), Gaps = 211/1239 (17%)
Query: 1022 KLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKE 1081
K+ L + ET ++ ++++ +E+ +K E E E + L Q K +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKEL----EEKMVTLMQEKNDLQLQ 894
Query: 1082 HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Q LA AEER L ++ + +A E+T+ + + L + L++E ++
Sbjct: 895 VQAEADSLADAEERCDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLES----------EPIRNSVKERESERNQCNFK 1191
++K+++DL L KV K KH +N E I KE+++ + + + +
Sbjct: 954 LKKDIDDL---ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ-EAHQQ 1009
Query: 1192 PQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ 1251
DL+ +E +++ ++LE + + E L++ +K + L+ + + GDL+ +
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 1252 DMQSQEISGLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
M + D ++ +E +SG ++ Q LQ ++ ++ ELE+ E
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129
Query: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370
+A + + + +D E + ++ E G +++ +N ++ D+
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE-MNKKREAEFQKMRRDL------ 1182
Query: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS 1430
E+ QH + A L + ++ AEL E+ +LQ + L + +M
Sbjct: 1183 EEATLQHEATAATLRKKHADS------------VAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 1431 KMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSL 1490
++ +L + ++++ +G+L K M LE+ LS + +
Sbjct: 1231 EIDDLASNMETVSKA-----------KGNLEK-MCRALED----QLSEIKTKEEEQQRLI 1274
Query: 1491 GDSSFYRALLE-QTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGV 1549
D + RA L+ ++G+ S L K+T V
Sbjct: 1275 NDLTAQRARLQTESGEYS--------------------------RQLDEKDTL------V 1302
Query: 1550 EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE-- 1607
+L + + Q +E+L+ ++E + K+ L L S R + D LR+QY E E
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSA----LAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 1608 -QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQL-QGLDLSSRSLLGIDTEDAIQ 1665
+ Q+ ++ E+ + Q + ELE A+ +L Q L D E+ ++
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ---------DAEEHVE 1409
Query: 1666 GRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQ 1725
N C + E T++ +++V +DL +D+E+ C+
Sbjct: 1410 AVNAKCA-----SLEKTKQRLQNEV---------EDLMIDVERTNAA--------CAALD 1447
Query: 1726 SPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLR 1785
N++ + Q E +EL S Q + S E +
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEAS--------------------QKESRSLSTELFK 1487
Query: 1786 LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK 1845
+ + E+ ++E+L E K L ++ Q+ + ELEKI ++++E S+L
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 1846 LEYFSCDHQELLQRVETSEG--LNSDLEMHADKSSRE-DIGDNVAKVNDSWKERFLDVEN 1902
LE E +E EG L LE++ KS + I + +++ + VE+
Sbjct: 1548 LE-------EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVES 1600
Query: 1903 ELSRIRSEKASIEHEALYL---------EADLEVVQTEKLCLE--KDNENKQKVIVC--- 1948
S + +E S ++A+ L E ++++ ++ E ++ N Q ++
Sbjct: 1601 MQSTLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659
Query: 1949 -----------LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL--ESHQ 1995
L+E+L++V N L+ E++ + L+Q K QEL S +
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELR---ATLEQTERSRKIAEQELLDASER 1716
Query: 1996 SECLHCIQVAEAEVKEKTEL-LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL 2054
+ LH + K+K E + + ++ +++++ + +EK + D+ ++ +
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE 1776
Query: 2055 ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKA----LEAALVE-KGEFALRLSS 2109
++ A L + K+ L + + LQ RL E++ L K LEA + E +GE
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1836
Query: 2110 TQEEVHQLR---RGIEKLRVRIEADEKKQLHIAE-------KLKERERENDSLKD----- 2154
E V LR R +++L + E D K L + + K+K +R+ + ++
Sbjct: 1837 NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVN 1896
Query: 2155 --KVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
K ++ EL+ +EE ++ + + + T+I
Sbjct: 1897 LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 181 bits (460), Expect = 8e-45
Identities = 279/1207 (23%), Positives = 496/1207 (41%), Gaps = 197/1207 (16%)
Query: 1766 QEDIHNLQLRVKETSNENLRL-------------LHVIEDRDRKVESLLNEMKELDSKLH 1812
+ ++ L L +++ EN++L L + ++ +VE L E+ KLH
Sbjct: 281 RHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLH 340
Query: 1813 --------LQEVQ----LMTKIEACIELEKI--------VGELKKENSDLSEKLEYFSCD 1852
++E++ ++ + +A +E + V EL+KEN L KL D
Sbjct: 341 DVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELD 400
Query: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
+R+E N LE+ +S E + W+ L +LS +
Sbjct: 401 RDTDKKRIEELLEENMVLEIAQKQSMNES-------AHLGWELEQLSKNADLSDASRKSF 453
Query: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT--- 1969
E E + L LEK+N++ Q I L + S+V E GEL+
Sbjct: 454 VFELN--------ECASSRILKLEKENQSLQSTIQGLRDA-SLVLEESGLKCGELEKENH 504
Query: 1970 -MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL---LQTLSSDVSE 2025
+SKK L E+ K+ Q+LE+ ++E ++EK +L ++TL +D +
Sbjct: 505 QLSKKIEKLQTQLEREKQSNQDLET----------LSEELIREKEQLQSDMETLKADKAR 554
Query: 2026 LLKD----KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
+KD K HL + SL + SQ S E ++ + KE + L + +LS+
Sbjct: 555 QIKDLEQEKDHLNRAMWSLRERSQVSS------EARMKDVEKENKALHQTVTEANGKLSQ 608
Query: 2082 SDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIEKLRVRIEADEKKQLH 2137
++EK + + LE A EKGE A +L QEE +L R + L E E + H
Sbjct: 609 LEFEKRQLHRDLEQAK-EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALE-H 666
Query: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE--VETLKTQIEEMA 2195
++ L+ R D ++N+ +L+ E + + LDAEN + VET++ ++A
Sbjct: 667 ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ--LDAENLELRRLVETMRFTSTKLA 724
Query: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
+ E + L EKE L K + + + ++L S++S+ E + + Q E S
Sbjct: 725 Q----MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQ-QSLESSS 779
Query: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
+ L+++L EL AL D E ++ L+ ++ L + +L + EK
Sbjct: 780 HKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK 839
Query: 2316 KQLCVLQQLKESEHHADLLKGRVENLEREL-----EIARTNQEHAALEAENSKGEVETLK 2370
+ + QQ++ + D ++ +E+E E+AR AA + + + + L
Sbjct: 840 EAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD--AAGKLKELEKDNRDLT 897
Query: 2371 AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ-EK 2429
++ ++L L D+V + + + L++EL K + ELE + + E +LQE +
Sbjct: 898 KQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ---ELEKVGLNRELLLQEDDSGSD 954
Query: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
+ K L+T L E++ L E + + L S+++ L+ E L Q
Sbjct: 955 TKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ 1014
Query: 2490 DEAKNNYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQE-QLVSKLSQVE 2545
E ++ LQ+S G GK+ +E + +++D+ +L + ++
Sbjct: 1015 GEGQH----LQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQ 1070
Query: 2546 GEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKM 2605
E QL KEQ L V +I LQ ++A LQ+ LQ+ L+ E
Sbjct: 1071 AEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSA 1130
Query: 2606 SFVEKV----NKMTAKETELQREMHEMAQKTAELQ------EELSGEKNRLAGELQLLLE 2655
+ + N TAKETE + + Q TA + E L R + E + L+
Sbjct: 1131 ALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIR 1190
Query: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLL 2715
+ K + L LE+ EL + H D ++++ ++ E
Sbjct: 1191 QHSCLKTLHRNLELEHKELGER----HGDMLKRKAELEE--------------------- 1225
Query: 2716 DTNKQYEVEIQTYREK-LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK--- 2771
REK LT++ E L ++ L + L L + +LK
Sbjct: 1226 -------------REKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEY 1272
Query: 2772 ----------KTKMDNLKY--------VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
KT ++N + ++LK++++ + L C+ L K L+
Sbjct: 1273 EELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLE 1332
Query: 2814 KE----LSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
+E LSQ+Q ++ + L + E KE E+ K +Y+DK +L
Sbjct: 1333 EENHHLLSQIQLLSQQNQM----------LLEQNMENKEQYHEEQK---QYIDKLNALRR 1379
Query: 2870 SHEKLEK 2876
EKLE+
Sbjct: 1380 HKEKLEE 1386
Score = 152 bits (383), Expect = 7e-36
Identities = 281/1283 (21%), Positives = 530/1283 (41%), Gaps = 231/1283 (18%)
Query: 32 KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQ 91
++KQ +L +A L++ +Q++E++ + + + E +L+ L+K KQ+ + +L
Sbjct: 247 EDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVL---ELQKVKQE-NIQLA 302
Query: 92 VKESQVNFQEGQLNSGKKQ---IEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKI 148
+L+S +++ +E+LE EL RCK +L DV
Sbjct: 303 ADARSARAYRDELDSLREKANRVERLELELTRCKEKLH---------DVD---------- 343
Query: 149 FTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIA 208
+ ++ E+L+E +E + LE ++ A +A R
Sbjct: 344 ----------FYKARMEELREDNIILIETKAMLEEQLTAARA--------------RGDK 379
Query: 209 RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANS 268
H+ EK L S + RD +E+ L+I ++ + +
Sbjct: 380 VHEL---------EKENLQLKSKLHDLELDRDTDKKRI---EELLEENMVLEIAQKQSMN 427
Query: 269 SFFDNSSSPHL---LDQLKAQNQELRN--------KINELE----LRLQGHEKEMKGQVN 313
S HL L+QL ++N +L + ++NE L+L+ + ++ +
Sbjct: 428 E------SAHLGWELEQL-SKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQ 480
Query: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
++ L LE++ ++ E EK ++ ++ + Q ++ LE ++L +
Sbjct: 481 GLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQ 540
Query: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
+ + E+ + ++IK+ E+E ++ L+R S + Q + +AR+ ++ K +H
Sbjct: 541 LQSDMETLKADKARQIKDLEQE-KDHLNRAMWSLRERSQ--VSSEARMKDVEKENKALHQ 597
Query: 434 VL---QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
+ +L +L K+QL +LE+ K+K RAE +L R ++ +++EN
Sbjct: 598 TVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAE-----------KLERELQRLQEENGR 646
Query: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
L AR+V LE + ++ ++SQ E + S +T+ + ++ Q
Sbjct: 647 L-------ARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTL-----QNVSLQLEG 694
Query: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
L + +L +LE +R + ++ + Q+ + + E+E + L ++L K +
Sbjct: 695 LERDNKQLDAENLELRR--LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK 752
Query: 611 ELKEEKTLFSCWKSENEKLLTQMES---EKENLQSKINHLET---CLKTQQIKSHEYNER 664
+ + + + +EN +L +ES + + L+S++ LE L+ N +
Sbjct: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ 812
Query: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD---------QKHQ 715
+ E DR+ L E+ L D K +E E ++L + +++ K D +K
Sbjct: 813 LEGAEKDRKALEQEVAQLEK--DKKLLEKEAKRL-WQQVELKDAVLDDSTAKLSAVEKES 869
Query: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE--YESLRDLLKSKDAS 773
+ ++ + G++++LE + L+ ++ R L + E L+ S +
Sbjct: 870 RALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD 929
Query: 774 LVTNEDHQ----RSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAIL- 828
++ E + R LL + + + G R+E L+ + K I+
Sbjct: 930 KLSQELEKVGLNRELLLQEDDSGSDTKYKILEG--------RNESALKTTLAMKEEKIVL 981
Query: 829 ----QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
SL LES+ QM L+K+CE L Q +GE + + SF +
Sbjct: 982 LEAQMEEKASLNRQLESELQM---LKKECETLRQNQGE-------GQHLQNSFKHPAGKT 1031
Query: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL 944
+ Q + T+ L K++ ++L E A +Q K+ LL++ L+ L
Sbjct: 1032 AASHQGKEAWGPGHKEATMELLRVKDRAIEL-----ERNNAALQAEKQ---LLKEQLQHL 1083
Query: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF-ANY 1003
+ + T S S I++L K+ L + N TL+ A L E L +S + A Y
Sbjct: 1084 ETQNVTFS------SQILTLQKQS-AFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQY 1136
Query: 1004 I----DEREKSISELSDQYKQEKL-----ILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
K S Q +QE+L LLQ E G +E S +Y+A ++S L+
Sbjct: 1137 TLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLK 1196
Query: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE- 1113
L +R ELE + + H + L + A EER + L E E +QQ R+
Sbjct: 1197 TL---------HRNLELEH--KELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNA 1245
Query: 1114 --MTDNQ-------------NNSKSEAGGLKQEIMTLKEEQNKMQKEVN------DLLQE 1152
M +NQ + K E L LK N Q E+N D L+E
Sbjct: 1246 LAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKE 1305
Query: 1153 NEQLMKVMKTK--HECQ-------NLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Q M + TK + C+ NLE E + + + + Q + ++E KE
Sbjct: 1306 QHQTMDISLTKLDNHCELLSRLKGNLEEEN-HHLLSQIQLLSQQNQMLLEQNMENKEQYH 1364
Query: 1204 DSYNAQLVQLEAMLRNKELKLQE 1226
+ + +L A+ R+KE KL+E
Sbjct: 1365 EEQKQYIDKLNALRRHKE-KLEE 1386
Score = 144 bits (364), Expect = 1e-33
Identities = 274/1329 (20%), Positives = 537/1329 (40%), Gaps = 194/1329 (14%)
Query: 1525 EVFCSSLQEENLTRKETPSAPAKGVEE------LESLCEVYRQSLEKLEEKMESQGIMKN 1578
E+ QE + + + P +P K SL +Q L +++
Sbjct: 208 ELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR 267
Query: 1579 KEIQELEQLLSSERQELDCL---RKQYLSENEQWQQKLTSVTL---EMESKLAAEKKQTE 1632
+E+++ + L R E+D L ++ EN Q S E++S L + + E
Sbjct: 268 QELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDS-LREKANRVE 326
Query: 1633 QLSLELEVARLQLQGLD--------LSSRSLLGIDTEDAIQGRNESCDI--SKEHTSETT 1682
+L LEL + +L +D L +++ I+T+ ++ + + K H E
Sbjct: 327 RLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKE 386
Query: 1683 ERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
K +H + + D D E + E ++ + S +S +E K
Sbjct: 387 NLQLKSKLHDL-ELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADL 445
Query: 1743 SECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802
S+ + N L +++ +LQ ++ + +L V+E+ K L
Sbjct: 446 SDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL----VLEESGLKCGELEK 501
Query: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE- 1861
E +L K+ + QL + ++ +LE + EL +E L +E D ++ +E
Sbjct: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQ 561
Query: 1862 TSEGLNSDLEMHADKS--SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
+ LN + ++S S E +V K N + + + +LS++ EK
Sbjct: 562 EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQ------ 615
Query: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979
L DLE + + EK LE EL + E +L ++K T+L+
Sbjct: 616 -LHRDLEQAKEKGERAEK-----------LERELQRLQEENGRL-------ARKVTSLET 656
Query: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE---K 2036
+EK+ E H+S+ L Q+ +++ + LQ +S + L +D L +
Sbjct: 657 ATEKV-----EALEHESQGL---QLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708
Query: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKE----------LLVKESESLQARLSESDYEK 2086
L+ L + + S ++E + QL +EKE L K+SE L+ E
Sbjct: 709 LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN 768
Query: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV---RIEADEKKQLHIAEKLK 2143
L + ++LE++ + L + E LRR +E LR+ ++E EK + + +++
Sbjct: 769 LRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVA 828
Query: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203
+ E++ L+ + + L +++++ ++ V+ D+ + VE +++ +
Sbjct: 829 QLEKDKKLLEKEAKRLWQQVEL----KDAVLDDSTAKLSAVEKESRALDKELARCRDAAG 884
Query: 2204 DLVTLRSEKENLTKQIQEKQGQLSEL--DKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
L L + +LTKQ+ L+ L D +L KS + L
Sbjct: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKS--------------------QQL 924
Query: 2262 QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL 2321
++L +L++ + + ++E++ + S + + RN L+ L E+K + +
Sbjct: 925 SSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNE-SALKTTLAMKEEKIVLLE 983
Query: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Q++E L+ ++ L++E E R NQ + K A +G
Sbjct: 984 AQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGP 1043
Query: 2382 GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAME 2441
G + T EL + ++R ELE N++ + EK +KE+ ++
Sbjct: 1044 G-----------HKEATMELLRVKDRAIELERNNAAL-------QAEKQLLKEQ----LQ 1081
Query: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
L+TQ + ++ L + L +Q L++E + L Y +LQ+
Sbjct: 1082 HLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQN 1141
Query: 2502 SVNGLIQEVEDGKQKLEKKDEEI-SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN 2560
+ +E E+ + L+++ E++ + + +QD E L + + E++ Q+ L+
Sbjct: 1142 --HHTAKETEN--ESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKT 1197
Query: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
L LE + + L ++ + L+ + EL + +K+ +T +
Sbjct: 1198 LHRNLELEHKELGERHGDM-------------LKRKAELEEREKV--------LTTEREA 1236
Query: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
LQ+E Q+T L GE RL GEL + K + +EL ELK SL+
Sbjct: 1237 LQQE-----QRTNAL---AMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLN- 1287
Query: 2681 MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740
+ E+ +Q R E +++HQ + + KL + E LS
Sbjct: 1288 ----------NAQLELNRWQARFDELKEQHQTMDISLT------------KLDNHCELLS 1325
Query: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD-NLKYVNQLKKENERAQGKMKLLI 2799
LK + EE N+ L + Q+L + + ++ N++ Q +E ++ K+ L
Sbjct: 1326 R-------LKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALR 1378
Query: 2800 KSCKQLEEE 2808
+ ++LEE+
Sbjct: 1379 RHKEKLEEK 1387
Score = 143 bits (361), Expect = 2e-33
Identities = 258/1149 (22%), Positives = 471/1149 (40%), Gaps = 150/1149 (13%)
Query: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET 1862
E++ L + L +L+ + + C EL IV DL+++ +Y H + +
Sbjct: 184 ELEALSRSMVLHLRRLIDQRDECTEL--IV--------DLTQERDYLQAQHPPSPIKSSS 233
Query: 1863 SEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLE 1922
++ S S ED ++ D+ K R V EL + HE L
Sbjct: 234 ADSTPSP----TSSLSSEDKQHLAVELADT-KARLRRVRQELEDKTEQLVDTRHEVDQLV 288
Query: 1923 ADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ---LRGELDTMSKKTTALDQ 1979
+L+ V+ E + L D + + +EL + + N+ L EL +K +D
Sbjct: 289 LELQKVKQENIQLAADARSAR----AYRDELDSLREKANRVERLELELTRCKEKLHDVDF 344
Query: 1980 LSEKMKEKTQ------ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
+M+E + E ++ E L + +V E + L S + +L D+
Sbjct: 345 YKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTD 404
Query: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA---------------- 2077
+++++ L +++ L + + + N+ A L E E L K ++ A
Sbjct: 405 KKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSR 464
Query: 2078 --RLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
+L + + + + L A + E L+ ++E HQL + IEKL+ ++E +++
Sbjct: 465 ILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSN 524
Query: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
+ +E RE + L+ +E L+ + + I D E K + + E
Sbjct: 525 QDLETLSEELIREKEQLQSDMETLKAD-------KARQIKDLEQEKDHLNRAMWSLRE-- 575
Query: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
RS E + + E + L + + E G+LS+L+ + L + EQA KE+ +
Sbjct: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKLSQLE---FEKRQLHRDLEQA----KEKGE 628
Query: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
A E L+ +L+ L E L ++ + ++ E L+ LR L+ +
Sbjct: 629 RA-EKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN 687
Query: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIAR-TNQEHAALEAENSKGEVETLKAKIE 2374
L QL+ E L L R +E R T+ + A +E EN ++E
Sbjct: 688 VSL----QLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQ---------QLE 734
Query: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKE 2434
+ LR + +L L K+ ER+ EL + S EN+ + Q E
Sbjct: 735 REKEELR-----------KNVDLLKALGKKSERL-ELSYQSVSAENLRLQ------QSLE 776
Query: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
SS + L+++L EL AL D EA + ++Q+E E ++ L Q + + +
Sbjct: 777 SSSHKTQTLESELGELEAERQALRRDLEALRL----ANAQLEGAEKDRKALEQEVAQLEK 832
Query: 2495 NYIVLQSSVNGLIQEVE-------DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
+ +L+ L Q+VE D KL ++E L ++ KL ++E +
Sbjct: 833 DKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKD 892
Query: 2548 HQ-LWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK--NLENELELTKMD- 2603
++ L K+ + R LT L + + + + K+ L L+ L + L EL L + D
Sbjct: 893 NRDLTKQVTVHARTLTT-LREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDS 951
Query: 2604 ----KMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS 2659
K +E N+ K T +E ++ A+++E+ S + +L ELQ+L +E ++
Sbjct: 952 GSDTKYKILEGRNESALKTTLAMKE-EKIVLLEAQMEEKASLNR-QLESELQMLKKECET 1009
Query: 2660 SKDQLKELTLENSELKKSL-DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD-T 2717
L++ E L+ S K +GK + + K +A+ L+
Sbjct: 1010 ----LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERN 1065
Query: 2718 NKQYEVEIQTYREKLTSKEE---CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
N + E Q +E+L E SSQ L + + +E N +L+ T K +
Sbjct: 1066 NAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT------AKLQ 1119
Query: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA-----QEKQKTG 2829
++N + L ++ + LL E E E LQ++ QL AA Q+ + G
Sbjct: 1120 VEN----STLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLG 1175
Query: 2830 TVMDTKVDELTTEI------KELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2883
T+ + + E I K L LE + KE E ++ +L +LE+ +++L T
Sbjct: 1176 TLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGE---RHGDMLKRKAELEEREKVLTT 1232
Query: 2884 QVAHLCSQQ 2892
+ L +Q
Sbjct: 1233 EREALQQEQ 1241
Score = 130 bits (328), Expect = 2e-29
Identities = 252/1174 (21%), Positives = 511/1174 (43%), Gaps = 190/1174 (16%)
Query: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQR 375
Q L ++L K L + L ++LV T + DQ + QK+K+ L+
Sbjct: 250 QHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLEL----QKVKQENIQLAADA 305
Query: 376 QNAESARCSLEQKIKEKEKEFQE---ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
++A + R L+ ++EK + EL+R + +D KAR+ +EL++ +
Sbjct: 306 RSARAYRDELDS-LREKANRVERLELELTRCKEKLHDVDF----YKARM-EELREDNIIL 359
Query: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
+A L++ + + + + E +++ + + ++ + ++ +EE+ +EN +L+
Sbjct: 360 IETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE 419
Query: 493 SHSEQKAREVCHLEAELKNIKQCLNQS----QNFAEEMKAKNTSQ----ETMLRDLQEKI 544
+Q E HL EL+ + + + S ++F E+ +S+ E + LQ I
Sbjct: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTI 479
Query: 545 -NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
++ SL LE+ L +LEK+ + L KK IE+L +L + ++ ++ L + E
Sbjct: 480 QGLRDASLVLEESGLKCGELEKE---NHQLSKK----IEKLQTQLEREKQSNQDLETLSE 532
Query: 604 LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL--------ETCLKTQQ 655
+E E+L+ + K++ + + +E EK++L + L E +K +
Sbjct: 533 ELIREKEQLQSD---METLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589
Query: 656 IKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715
++ ++ V L E R LH L+ + E + ELQ+ E + + +
Sbjct: 590 KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLAR 649
Query: 716 KEIENMCLKTSQLTGQVEDLEHK-----------------LQLLSNEIMDKDRCYQDLHA 758
K L+T+ T +VE LEH+ LQ +S ++ +R + L A
Sbjct: 650 KVTS---LETA--TEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDA 704
Query: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC---- 814
E LR L+++ + +R +++ +++ G SER E
Sbjct: 705 ENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK-KSERLELSYQS 763
Query: 815 ----RLEADQSPKNSAILQNRVDSLEFSLESQKQ-MNSDLQ------KQCEELVQIKGEI 863
L QS ++S+ ++S LE+++Q + DL+ Q E + + +
Sbjct: 764 VSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKAL 823
Query: 864 EENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETE 923
E+ + + E+ + + + ++R+ + E A + LSA+E + + L +
Sbjct: 824 EQEVAQLEK-DKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDA 882
Query: 924 QAEIQELKKSNHLLEDSL----KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL 979
+++EL+K N L + + L L E L LEK + + S E+++L+QE L
Sbjct: 883 AGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS----ELDKLSQE---L 935
Query: 980 KEINASLNQEKMNLIQKSESFANY--IDEREKSISELSDQYKQEKLILLQRCEETGNAYE 1037
+++ LN+E + S S Y ++ R +S + + K+EK++LL+
Sbjct: 936 EKV--GLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLE---------A 984
Query: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENR------KNELE----------QLKEAFAKE 1081
+ +K ++ S+L+ L EC +L +N+ +N + Q KEA+
Sbjct: 985 QMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPG 1044
Query: 1082 HQEFLTKLAFAEER-------NQNLMLELETVQQALRSEMTDNQNNS------KSEAGGL 1128
H+E +L ++R N L E + +++ L+ T N S + ++ L
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL 1104
Query: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQL---MKVMKTKHECQNLESEPIR---------- 1175
++ TL+ + K+Q E + L ++ L +++ H + E+E ++
Sbjct: 1105 QEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAY 1164
Query: 1176 ----------NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQ 1225
++ ER+S + + L+ +L+ + +L + + ++ +L+
Sbjct: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
Query: 1226 ESEK----EKECLQHELQT----------IRGDLETSNLQDMQSQEISGLKDCEIDAEEK 1271
E EK E+E LQ E +T +RG+L+ N Q + G + E+ A K
Sbjct: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ---LKGEYE-ELHAHTK 1280
Query: 1272 YISGPHELSTSQNDNAHLQCS-LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT 1330
EL TS N NA L+ + Q ++L E + +I +T+L D+ E ++
Sbjct: 1281 ------ELKTSLN-NAQLELNRWQARFDELKEQHQTMDI-------SLTKL-DNHCELLS 1325
Query: 1331 ATR-KMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
+ + EE LL+++++L+ + +L + +E+
Sbjct: 1326 RLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMEN 1359
Score = 126 bits (317), Expect = 3e-28
Identities = 280/1344 (20%), Positives = 561/1344 (41%), Gaps = 205/1344 (15%)
Query: 410 LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
L+Q +Q+ R T + + K+++N + + LT + + ++ +E Q+L
Sbjct: 47 LNQIMLQIDPRPTNQ-RINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVL 105
Query: 470 SQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
++ +SMEE+KK L+ C ++ E K + F E +K
Sbjct: 106 MIGRDPLSGKSMEEIKKVLLLVLG---------CAVQCERK---------EEFIERIKQL 147
Query: 530 NT-SQETMLRDLQEKINQQENSLTLEKLKL---AVADLE--------------KQRD-CS 570
+ +Q ++ +QE + QEN L+ L+L A +LE QRD C+
Sbjct: 148 DIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECT 207
Query: 571 Q---DLLKKREHHIEQ------LNDKLSKTEKESKALLS------ALELK------KKEY 609
+ DL ++R++ Q + T + +L S A+EL ++
Sbjct: 208 ELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVR 267
Query: 610 EELKEEKTLFSCWKSENEKLLTQMESEK-ENLQSKINHLETCLKTQQIKS-HEYNERVRT 667
+EL+++ + E ++L+ +++ K EN+Q + ++ S E RV
Sbjct: 268 QELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVER 327
Query: 668 LEMDRENLSVEIRN-------LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
LE++ ++ + + + + + +ET+ + +L D+ H+ E EN
Sbjct: 328 LELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKEN 387
Query: 721 MCLKTSQLTGQVE---DLEHKLQLLSN----EIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
+ LK+ +++ D + +LL EI K + H +E L L K+ D S
Sbjct: 388 LQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWE-LEQLSKNADLS 446
Query: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE----------RSECRLEADQSPK 823
D R F+ + E S+ S E L+ + K
Sbjct: 447 -----DASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEK 501
Query: 824 NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL--MKAEQMHQSFVAET 881
+ L +++ L+ LE +KQ N DL+ EEL++ K +++ ++ +KA++ Q + +
Sbjct: 502 ENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQ--IKDL 559
Query: 882 SQRISKLQEDT-SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Q L S + + + +++ EKE + L+ V ++ +L+ L
Sbjct: 560 EQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRD 619
Query: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
L++ + EK E + + +RE++ L +ENG L SL +K E+
Sbjct: 620 LEQAK--------EKGERAEKL---ERELQRLQEENGRLARKVTSLE----TATEKVEAL 664
Query: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC 1060
E E +L ++ ++ L LQ E L + K +N +L L+ E
Sbjct: 665 -----EHESQGLQLENRTLRKSLDTLQ---NVSLQLEGLERDNKQLDAENLELRRLV-ET 715
Query: 1061 TSLCENRKNELEQLKEAFAKEHQEF---LTKLAFAEERNQNLMLELETVQ-QALRSEMTD 1116
+ ++E+ + +E +E + L ++++ L L ++V + LR + +
Sbjct: 716 MRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSL 775
Query: 1117 NQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK----HECQNLESE 1172
++ K++ L+ E+ L+ E+ +++++ L N QL K + E LE +
Sbjct: 776 ESSSHKTQT--LESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKD 833
Query: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL--VQLEAMLRNKEL-------- 1222
+ E+E++R +E+K+ LD A+L V+ E+ +KEL
Sbjct: 834 ---KKLLEKEAKR------LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAG 884
Query: 1223 KLQESEKEKECLQHE-------LQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275
KL+E EK+ L + L T+R DL L+ ++SQ++S D ++ E + +
Sbjct: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLV---LEKLKSQQLSSELD-KLSQELEKVGL 940
Query: 1276 PHELSTSQNDNAHLQCSLQTTMNKLNE--LEKICEILQAEKYELVTELNDSRSECITATR 1333
EL ++D+ T K+ E E + A K E + L E + R
Sbjct: 941 NRELLLQEDDSG------SDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
Query: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDI---PGGEFGEQPNEQHPVSLAPLDESNSY 1390
++ E+ L E + L + G G+ +++ P G+ + Q + P + +
Sbjct: 995 QLESELQMLKKECETLRQNQG--EGQHLQNSFKHPAGK--TAASHQGKEAWGPGHKEATM 1050
Query: 1391 EHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLS 1450
E L + D+ + EL+ +LQ+E ++L +Q + ++ + + +L+ ++ L
Sbjct: 1051 ELLRVKDRAI-----ELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQ 1105
Query: 1451 TNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
+ Q K L +E + S S++ + L + ++T + SL
Sbjct: 1106 EHNTTLQTQTAK---LQVENSTLSSQSAALTAQYTLLQN-------HHTAKETENESLQR 1155
Query: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLE-KLEEK 1569
E +A + + + E T E SA + + S + ++LE + +E
Sbjct: 1156 QQEQLTAAYEALLQD------HEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 1209
Query: 1570 MESQGIM--KNKEIQELEQLLSSERQELDCLRKQ---YLSENEQWQQKLTSVTL---EME 1621
E G M + E++E E++L++ER+ L ++ + EN++ + +L V +++
Sbjct: 1210 GERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLK 1269
Query: 1622 SKLAAEKKQTEQLSLELEVARLQL 1645
+ T++L L A+L+L
Sbjct: 1270 GEYEELHAHTKELKTSLNNAQLEL 1293
Score = 104 bits (259), Expect = 2e-21
Identities = 194/995 (19%), Positives = 399/995 (40%), Gaps = 167/995 (16%)
Query: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63
+L+ +GL +L ++E + +L+KE Q +++ L+ L+++KQ ++ +T
Sbjct: 474 SLQSTIQGLRDASLV-LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSE 532
Query: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
L RE ++L E+L+ K + +L+ ++ +N L + Q+ E +K +
Sbjct: 533 ELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRE-RSQVSS-EARMKDVEK 590
Query: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
E + Q A+ L+ ++ L ++ G + E L+ + + EE RL
Sbjct: 591 ENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK-EKGERAEKLERELQRLQEENGRLAR 649
Query: 184 EVKALQA----------------------KKASQTLPQATMNHRDIARHQAS-------- 213
+V +L+ +K+ TL ++ + R
Sbjct: 650 KVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLEL 709
Query: 214 ---------SSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKR 264
+S Q E+ L + D + + + S ++
Sbjct: 710 RRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENL 769
Query: 265 DANSSFFDNSSSPHLLD----QLKAQNQELRNKINELEL---RLQGHEKEMKGQVNKFQE 317
S +S L+ +L+A+ Q LR + L L +L+G EK+ K ++
Sbjct: 770 RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA----LEQ 825
Query: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
QLEK K +L+EKE + ++ A D ++ K +A+E++ + L ++L
Sbjct: 826 EVAQLEKDK-KLLEKE--AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKEL------ 876
Query: 378 AESARC-SLEQKIKEKEK---EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
ARC K+KE EK + ++++ R+ TL ++ + K + Q
Sbjct: 877 ---ARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQ---------- 923
Query: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK------ENELRRSMEEMKKE 487
L +ELDKL+ +++ N ++ L + + + ++ K E+ L+ ++ +++
Sbjct: 924 -LSSELDKLSQELEKVGLN----RELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEK 978
Query: 488 NNLLKSHSEQKAREVCHLEAELKNI-KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
LL++ E+KA LE+EL+ + K+C QN E +N+ + + +
Sbjct: 979 IVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGK 1038
Query: 547 QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606
+ A ++ + +LL+ ++ IE E+ + AL + +L K
Sbjct: 1039 E-------------AWGPGHKEATMELLRVKDRAIE--------LERNNAALQAEKQLLK 1077
Query: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
++ + L+ + FS ++LT ++ + LQ T L+TQ K N +
Sbjct: 1078 EQLQHLETQNVTFS------SQILT-LQKQSAFLQEH----NTTLQTQTAKLQVENSTLS 1126
Query: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQK----LAYMELQQKAEFSDQKHQKEI---- 718
+ ++N H ++++ ++ Q+ AY L Q E H+++
Sbjct: 1127 SQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYE 1186
Query: 719 ----ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
++ CLKT L L+L E+ ++ AE E +L ++ +L
Sbjct: 1187 ALIRQHSCLKT---------LHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREAL 1237
Query: 775 VTNE--------DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSA 826
+ ++QR D+ +HH + GE + + E + + +
Sbjct: 1238 QQEQRTNALAMGENQRLRGELDRVNFLHH---QLKGEYEELHAHTKELKTSLNNAQLELN 1294
Query: 827 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE-------NLMKAEQMHQSFVA 879
Q R D L+ ++ + L CE L ++KG +EE + Q +Q +
Sbjct: 1295 RWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLE 1354
Query: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
+ + + E+ Q + L+AL +++L+
Sbjct: 1355 QNMENKEQYHEE----QKQYIDKLNALRRHKEKLE 1385
Score = 103 bits (256), Expect = 3e-21
Identities = 291/1411 (20%), Positives = 539/1411 (38%), Gaps = 211/1411 (14%)
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ QE + LQ E A E+L ++ +L +ECT L +L Q ++
Sbjct: 164 HNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIV----DLTQERDY 219
Query: 1078 FAKEHQEFLTKLAFAE-----------ERNQNLMLELETVQQALR------SEMTDNQNN 1120
+H K + A+ E Q+L +EL + LR + T+ +
Sbjct: 220 LQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVD 279
Query: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
++ E L E+ +K+E ++ + ++L + + + + LE E R K
Sbjct: 280 TRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKL 339
Query: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
+ + + + +L I L A L + R + K+ E EKE L+ +L
Sbjct: 340 HDVDFYKARME---ELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHD 396
Query: 1241 IRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL 1300
+ D +T + + E ++ ++ +K S N++AHL L+
Sbjct: 397 LELDRDTDKKRIEELLE----ENMVLEIAQKQ---------SMNESAHLGWELE------ 437
Query: 1301 NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKL---LNEVKILNDDSGLLH 1357
+L K ++ A + V ELN+ S I K + + L + ++ ++SGL
Sbjct: 438 -QLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKC 496
Query: 1358 GELVEDIPGGEFGEQPNEQHPVSLAPLD-----ESNSYEHLTLSDKEVQMHFAELQEKFL 1412
GEL E+ N Q + L E S + L +E+ +LQ
Sbjct: 497 GEL----------EKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
Query: 1413 SLQSEH----KILHDQHCQMSSKMSEL--------QTYVDSLKAENLVLSTNLRNFQGDL 1460
+L+++ K L + ++ M L + + ++ EN L + G L
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKL 606
Query: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL-LSNLEGAVSAN 1519
QL E+ + L + L E+ G ++ +++LE A
Sbjct: 607 ---SQLEFEKRQLHRDLEQAKEKGERAEKLERE--LQRLQEENGRLARKVTSLETATEKV 661
Query: 1520 QCSVDEVFCSSLQEENLTRKET------PSAPAKGVE-----------ELESLCEVYRQS 1562
+ E LQ EN T +++ S +G+E EL L E R +
Sbjct: 662 EALEHE--SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFT 719
Query: 1563 LEKLEEKMESQGIMKNKEIQELEQ------LLSSERQELDCLRKQYLSENEQWQQKLTSV 1616
KL + ME + +E +EL + L + + L+ + +EN + QQ L S
Sbjct: 720 STKLAQ-MERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESS 778
Query: 1617 ---TLEMESKLAAEKKQTEQLSLELEVARL---QLQGLDLSSRSLLGIDTEDAIQGRNES 1670
T +ES+L + + + L +LE RL QL+G + ++L E
Sbjct: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKAL-----------EQEV 827
Query: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQD---LNLDIEKITETGAVKPTGECSGEQSP 1727
+ K+ + E+ K Q+ KDA D L + K C
Sbjct: 828 AQLEKD--KKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGK 885
Query: 1728 DTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLL 1787
E D T+ + L+ +ED+ +L+ ++ S+E +L
Sbjct: 886 LKELEKDNRDLTKQVTVHARTLTTL-------------REDLVLEKLKSQQLSSELDKLS 932
Query: 1788 HVIEDRDRKVESLLNEMKE-LDSKLHLQE--------VQLMTKIEACIELEKIVGELKKE 1838
+E E LL E D+K + E L K E + LE + E
Sbjct: 933 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASL 992
Query: 1839 NSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFL 1898
N L +L+ + + L Q + L + + A K++ G ++W
Sbjct: 993 NRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG------KEAWGPGHK 1046
Query: 1899 DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN-------KQKVIVCLEE 1951
+ EL R++ +E L+A+ ++++ + LE N QK L+E
Sbjct: 1047 EATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQE 1106
Query: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQ----LSEKMKEKTQELESHQSECLHCIQVAEA 2007
+ + ++ +L+ E T+S ++ AL L K E ES Q + EA
Sbjct: 1107 HNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEA 1166
Query: 2008 EVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
+++ E L TL S++ L++ + L+ ++LE + + L ++ + A+L +
Sbjct: 1167 LLQDH-EHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEE 1225
Query: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
+++L E E+LQ + A+ E L HQL+ E+
Sbjct: 1226 REKVLTTEREALQQE-----------QRTNALAMGENQRLRGELDRVNFLHHQLKGEYEE 1274
Query: 2124 LRVRIEADEKKQLHIAE-KLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
L + + K L+ A+ +L + D LK++ + ++ L + + EL+ N +
Sbjct: 1275 LHAHTK-ELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEE 1333
Query: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
E L +QI+ +++ + + L EN +Q E+Q Q +DKL +L
Sbjct: 1334 ENHHLLSQIQLLSQQ------NQMLLEQNMEN-KEQYHEEQKQY--IDKL----NALRRH 1380
Query: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE-EEHQLRN 2301
KE+ E +I ++ K K+ N + A KA + + P E +L++
Sbjct: 1381 KEKLEEKIMDQYK----FYDPPPKKKNHWIGA--------KALVKLIKPKKEGSRERLKS 1428
Query: 2302 SIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
+++ +LE+ + Q L+ + D
Sbjct: 1429 TVDSPPWQLESSDPASPAASQPLRSQAENPD 1459
Score = 102 bits (253), Expect = 8e-21
Identities = 279/1340 (20%), Positives = 511/1340 (38%), Gaps = 233/1340 (17%)
Query: 731 QVEDLEHKLQLLSNEIMD-KDRCYQDLHAEYESLRDLLKS-------KDASLVTNEDHQR 782
++E L + L ++D +D C +L + RD L++ K +S +
Sbjct: 184 ELEALSRSMVLHLRRLIDQRDEC-TELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTS 242
Query: 783 SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQ 842
SL + D+Q ++ E + R E + + ++ VD L L+
Sbjct: 243 SLSSEDKQ--------HLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKV 294
Query: 843 KQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET------------SQRISKLQE 890
KQ N L + E++ KA ++ + + T R+ +L+E
Sbjct: 295 KQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELRE 354
Query: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE-----DSLKELQ 945
D ++ ET + LE + + DKV + E +LK H LE D + +
Sbjct: 355 DNI----ILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEE 410
Query: 946 LLSETLSLE---KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
LL E + LE K+ M+ L E+E+L++ N L + AS L + + S
Sbjct: 411 LLEENMVLEIAQKQSMNESAHLGW-ELEQLSK-NADLSD--ASRKSFVFELNECASSRIL 466
Query: 1003 YIDEREKSISELSDQYKQEKLILLQ---RCEETGNAYEDLSQKYKAAQ-------EKNSK 1052
+++ +S+ + L+L + +C E LS+K + Q + N
Sbjct: 467 KLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQD 526
Query: 1053 LECLLNECTSLCENRKNELEQLKEAFAKE------HQEFLTKLAFA-EERNQ----NLML 1101
LE L E E ++++E LK A++ ++ L + ++ ER+Q M
Sbjct: 527 LETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMK 586
Query: 1102 ELETVQQALRSEMTD-------------------NQNNSKSE-AGGLKQEIMTLKEEQNK 1141
++E +AL +T+ Q K E A L++E+ L+EE +
Sbjct: 587 DVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGR 646
Query: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD-LEVKE 1200
+ ++V L E KV +HE Q L+ E N + + Q N Q++ LE
Sbjct: 647 LARKVTSLETATE---KVEALEHESQGLQLE---NRTLRKSLDTLQ-NVSLQLEGLERDN 699
Query: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
LD+ N +L +L +R KL + E+E + L+ E + +R +++ +S+ +
Sbjct: 700 KQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLE- 758
Query: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
L + AE N LQ SL+++ +K LE L+AE+ L +
Sbjct: 759 LSYQSVSAE----------------NLRLQQSLESSSHKTQTLESELGELEAERQALRRD 802
Query: 1321 LNDSRSECITATRKMAEEVGKLL-NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPV 1379
L R A + AE+ K L EV L D LL E ++ +Q +
Sbjct: 803 LEALR--LANAQLEGAEKDRKALEQEVAQLEKDKKLLEKE----------AKRLWQQVEL 850
Query: 1380 SLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYV 1439
A LD+S + L+ +KE + +L E D + K+ EL+
Sbjct: 851 KDAVLDDSTA--KLSAVEKESR-----------ALDKELARCRD----AAGKLKELEKDN 893
Query: 1440 DSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRAL 1499
L + V + L + DLV LE+ LSS S L +G R L
Sbjct: 894 RDLTKQVTVHARTLTTLREDLV------LEKLKSQQLSSELDKLSQELEKVG---LNREL 944
Query: 1500 LEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVY 1559
L Q D + + N+ ++ +++EE + L E
Sbjct: 945 LLQEDDSGSDTKYKILEGRNESALKTTL--AMKEEKIV-----------------LLEAQ 985
Query: 1560 RQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE-------NEQW--- 1609
+ L ++ES+ M KE + L Q E Q L K + E W
Sbjct: 986 MEEKASLNRQLESELQMLKKECETLRQ-NQGEGQHLQNSFKHPAGKTAASHQGKEAWGPG 1044
Query: 1610 QQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNE 1669
++ T L ++ + ++ L E ++ + QLQ L+ + + I +
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN-----VTFSSQILTLQK 1099
Query: 1670 SCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDT 1729
+EH + +T K L +E T + + + + +
Sbjct: 1100 QSAFLQEHNTTLQTQTAK----------------LQVENSTLS---SQSAALTAQYTLLQ 1140
Query: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH- 1788
N+ E + + +L+ + L + LG + + + + L+ LH
Sbjct: 1141 NHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHR 1200
Query: 1789 VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
+E +++ +M + ++L +E L T+ EA + ++ EN L +L+
Sbjct: 1201 NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
Query: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF---------LD 1899
+ H +L E E+HA + +N + W+ RF +D
Sbjct: 1261 VNFLHHQLKGEYE---------ELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMD 1311
Query: 1900 V-----ENELSRIRSEKASIEHEALYLEADLEVV-QTEKLCLEKDNENKQKVIVCLEEEL 1953
+ +N + K ++E E +L + ++++ Q ++ LE++ ENK++ EE
Sbjct: 1312 ISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQ----YHEEQ 1367
Query: 1954 SVVTSERNQLRGELDTMSKK 1973
+ N LR + + +K
Sbjct: 1368 KQYIDKLNALRRHKEKLEEK 1387
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 180 bits (457), Expect = 2e-44
Identities = 283/1356 (20%), Positives = 568/1356 (41%), Gaps = 210/1356 (15%)
Query: 1532 QEENLTRKETPSAPAK-GVEELESLCEVYRQSLE---KLEEKMESQGIMKNKEIQELEQL 1587
+ E L PS P E++C++ S + K +KM S ++EI+ L +
Sbjct: 178 RSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREK 237
Query: 1588 LSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
L+ RQ+ CL +++N K S+ E+ A ++S+ LE A+ Q
Sbjct: 238 LNKLRQQNACL----VTQNHSLMTKFESIHFELTQSRA-------KVSM-LESAQQQAAS 285
Query: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIE 1707
+ + ++ ++ E + Q + V + + +Q + IE
Sbjct: 286 VPILEEQIINLEAEVSAQDK----------------------VLREAENKLEQSQKMVIE 323
Query: 1708 KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE 1767
K E + EC + G+ + +E L N E
Sbjct: 324 K--EQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEA-----------------LYNAE 364
Query: 1768 DIHNLQLRVKETSNENLRLLHVIED-RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826
++ + K+ E L + E+ +R + + E K L + L + +L
Sbjct: 365 ELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI------ 418
Query: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDI-GDN 1885
L++ + +LK+EN++ EKL + + E++ ++ +E S L++ ++ ++++I D
Sbjct: 419 -LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQL--TESRQSILKLESELENKDEILRDK 475
Query: 1886 VAKVNDSWK---------ERFLDVENELSRIRSEKASIEHEALYLEADLEVV----QTEK 1932
+ +N++ + ER + E+ R E S+E L E+ K
Sbjct: 476 FSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSK 535
Query: 1933 LCLEKDNENKQKVIVCLEEELSVVTSERNQL---RGELDTMSKKTTALDQLSEKM----- 1984
+ + + + I C E V++ R +L E+ + TA +QLS+ +
Sbjct: 536 YQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTA-NQLSQSLITCND 594
Query: 1985 KEKTQELESHQSECLHC--IQVAEAEVKEKTE--LLQTLSSDVSELLKDKTHLQEKLQSL 2040
+++ +L S ++E + QVAE+ VK++ + + + + L+ L+ KL +
Sbjct: 595 SQESSKLSSLETEPVKLGGHQVAES-VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI 653
Query: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
E ++ L + +Q + +E S L++ +++ + L + K LE +V
Sbjct: 654 EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY 713
Query: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK---------QLHIAEKLKERERENDS 2151
A + + ++E+ + I L I + +K ++H+ E+ KE E++ +
Sbjct: 714 SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHL-EQHKEMEKQIER 772
Query: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE 2211
L+ ++E +++ + E+ ++ D + +E+L + E +K
Sbjct: 773 LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK------------ 820
Query: 2212 KENLTK---------QIQEKQGQLSELDKLLSSFKSLLE--------EKEQAEIQIKEES 2254
KEN+ K Q+ E+ ++ +LD L K L KE+ E Q+K++S
Sbjct: 821 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 880
Query: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADE 2314
+ V LQ +LK N ++ I++ T Q +++E +E + +LE
Sbjct: 881 EE-VYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV 939
Query: 2315 KKQLCVLQQLKESE---------------HHADLLKGRVENLERELEIARTNQEHAALEA 2359
K LQ+ +ES H ADL + +V L + + +
Sbjct: 940 SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ--YKE 997
Query: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
E SK E E + K +G +++ +LD++ +++ EL+K+ + ELE + S E
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK-----TELEKKTNAVKELEKLQHSTE 1052
Query: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
L E Q++ E+L+T+L+ H + ++ + Q L
Sbjct: 1053 TELTEALQKR-----------EVLETELQNA-------HGELKSTLRQLQELRDV----- 1089
Query: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
L+KAQL L+E L + + E+ED KQ+L + D+ + +++ + V+
Sbjct: 1090 LQKAQL--SLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT 1147
Query: 2540 KLSQVEGEHQLWKEQNL-----ELRNLTVELEQKIQVLQSKNASLQDTLEVL-QSSYKNL 2593
L EH+ EQ + L +EL++ + ++S N LQ+ E L + + L
Sbjct: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIML 1207
Query: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
+NE E++++ K ++ + + E++ M E Q A +E L EL+L
Sbjct: 1208 QNEQEISQLKK-----EIERTQQRMKEMESVMKEQEQYIATQYKEAID----LGQELRLT 1258
Query: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKD-----QVEKE-----GKVREEIAEYQLRL 2703
E++++S +L E + + ++ ++ + + Q+ KE + EE+ ++R
Sbjct: 1259 REQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
Query: 2704 HEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKAT 2763
E + QA + + + E + Y ++ S +E + K+ D KSS ++LN L+
Sbjct: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
Query: 2764 TQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI 2799
LEE + T + NL Q++ NE + + L+
Sbjct: 1379 KLELEEAQDT-VSNLH--QQVQDRNEVIEAANEALL 1411
Score = 175 bits (444), Expect = 5e-43
Identities = 254/1175 (21%), Positives = 506/1175 (43%), Gaps = 147/1175 (12%)
Query: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826
++I +L+ ++ + +N L+ K ES+ E+ + +K+ + E I
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
Query: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886
E+I+ L+ E S + L +E ++E S+ + + E +S E I V
Sbjct: 289 LEEQIIN-LEAEVSAQDKVL-------REAENKLEQSQKMVIEKEQSLQESKEECIKLKV 340
Query: 1887 AKVNDSWKERFLDVENELSRIRSEKAS--IEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
+ + + + + + + +E+ S + + LE VQ E+ LE++ N +K
Sbjct: 341 DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK 400
Query: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004
L+E + SE L+ +L + ++ + M K E+ + +E I
Sbjct: 401 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460
Query: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL---ENQIAQL 2061
E+E++ K E+L+ S ++E + K + + + L+ Q + ++ EL E I+QL
Sbjct: 461 LESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQL 520
Query: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
++EL +S + ++S ++ EA + E ++L+ + E+ +L +
Sbjct: 521 PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL 580
Query: 2122 ------EKLRVRIEADEKKQL-------------HIAEKLKERERENDSLKDKVENLERE 2162
+ L ++ E +L +AE +K++ + + + + E
Sbjct: 581 TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLV 640
Query: 2163 LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222
+ E +L+ ++AENS LK + ++ + +L+ S L ++ +K
Sbjct: 641 TGIEELRTKLIQIEAENSD-----LKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
Query: 2223 QGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL-----CG 2277
QL L+K L EEK A I ++ L+ +L E NE + +L
Sbjct: 696 CSQLLTLEKQL-------EEKIVAYSSIAAKNAE----LEQELMEKNEKIRSLETNINTE 744
Query: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA------DEKKQLCVLQQ-LKESEHH 2330
++I A E++ +E+ ++ IE+L A+LE +++K + +LQQ + +HH
Sbjct: 745 HEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
Query: 2331 ADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL--RGLELDVV 2388
+ L + + E++ ++ A +N E ET+K + + L L +
Sbjct: 805 LESLDRLLTESKGEMKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLN 863
Query: 2389 TIRSEKENLTNELQKEQERI----SELEIINSSFEN------ILQEKEQEKVQMKEKSST 2438
+ KE +L+K+ E + EL+I N S + ILQ Q++ QM ++ +
Sbjct: 864 QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
Query: 2439 AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498
L+ +L ++V+ L +QE K +E + + ++ +E + D + I
Sbjct: 924 RNGELEDTQTKLEKQVSKL--EQELQKQRESS-AEKLRKMEEKCESAAHEADLKRQKVIE 980
Query: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558
L + + E++ K++L K ++EI LK +D E LSQ++ + L
Sbjct: 981 LTGTARQVKIEMDQYKEELSKMEKEIMHLK---RDGENKAMHLSQLD----------MIL 1027
Query: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
ELE+K ++ LE LQ S E ELT E + K E
Sbjct: 1028 DQTKTELEKKTNAVKE--------LEKLQHS-----TETELT--------EALQKREVLE 1066
Query: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
TELQ E+ +LQE + + QL LEE ++ +K+LT E E K +
Sbjct: 1067 TELQNAHGELKSTLRQLQE-----LRDVLQKAQLSLEEKYTT---IKDLTAELRECKMEI 1118
Query: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC 2738
+ ++ +E + ++E ++L+ A+ H + T +++ E++ +K+ E
Sbjct: 1119 EDKKQELLEMDQALKER--NWELKQRAAQVTHLDM---TIREHRGEME---QKIIKLEGT 1170
Query: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLL 2798
L +LE+ E LN+ L+ + L E + + N + ++QLKKE ER Q +MK +
Sbjct: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230
Query: 2799 IKSCKQLEE------------------EKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
K+ E+ +E +Q ++L A+ +Q +++ L+
Sbjct: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQ---VQAQREIERLS 1287
Query: 2841 TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875
+E++++K+ +EK + ++ + + LE
Sbjct: 1288 SELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
Score = 154 bits (389), Expect = 1e-36
Identities = 225/1109 (20%), Positives = 471/1109 (42%), Gaps = 120/1109 (10%)
Query: 1 MSWALEEWKEGLPTRALQKIQE----LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE 56
+S A +++K+ + + L+K+Q LE L +KE ++ Q + ++ L+ K+K+
Sbjct: 366 LSKAFQQYKKKVAEK-LEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR 424
Query: 57 NEKTEGTNLKRENQRLM-----EICESLEKTKQ---KISHELQVKESQVNFQEGQLNSGK 108
K E N K E R+M E+ L +++Q K+ EL+ K+ + + +N +
Sbjct: 425 QLKEENNNGK-EKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
Query: 109 K---QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIF--TTPLTPSQYYSGSK 163
+ ++ + L C+ E+E S+ +S + ++ +++F + L+ Q S S
Sbjct: 484 ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN 543
Query: 164 YEDLKE---KYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220
ED + NK V R++ +K + +K H ++ +Q S S+ +
Sbjct: 544 KEDRCIGCCEANKLVISELRIKLAIKEAEIQKL----------HANLTANQLSQSLITCN 593
Query: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
+ S LSS + P++ G +V S +D N N
Sbjct: 594 DSQESSKLSS-LETEPVKL--------GGHQVAES-------VKDQNQHTM-NKQYEKER 636
Query: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ-LEKAKVELIEKEKVLNKC 339
+L +ELR K+ ++E + M + ++FQ +Q + LEKA + ++ KC
Sbjct: 637 QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 696
Query: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399
+L+ Q ++ Y+++ K +L ++L + + S ++ + ++ F++
Sbjct: 697 -SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKA 755
Query: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ----LENNLEE 455
+ ++++ +++A+L ++ QQ K E +K S+ QQ +++LE
Sbjct: 756 KKIHLEQHKEMEKQIERLEAQLEKKDQQFK--------EQEKTMSMLQQDIICKQHHLES 807
Query: 456 FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQC 515
+ L ++ + +K++E ++++ E +K A E+C E L ++ Q
Sbjct: 808 LDRLLTESKGEMKKENMKKDEALKALQNQVSEET-IKVRQLDSALEICKEELVL-HLNQL 865
Query: 516 LNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLK 575
+ F +++K K S+E + KI T E+ + L++Q Q +L+
Sbjct: 866 EGNKEKFEKQLKKK--SEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ----QQMLQ 919
Query: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
+ +L D +K EK+ +S LE + ++ E EK + E+
Sbjct: 920 QETIRNGELEDTQTKLEKQ----VSKLEQELQKQRESSAEKL------RKMEEKCESAAH 969
Query: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLE-------MDRENLSVEIRNLHNVLDS 688
E + + K+ L + +I+ +Y E + +E D EN ++ + L +LD
Sbjct: 970 EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
Query: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
E+E + A EL++ ++ + + ++ + ++L +L+ L+ L
Sbjct: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
Query: 749 KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ------------QPAMHHS 796
+ L +Y +++DL + ED ++ LL DQ + H
Sbjct: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
Query: 797 FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD-----LQK 851
I +G M + + ++S +++SL L++ K+ + LQ
Sbjct: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
Query: 852 QCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
+ +E+ Q+K EIE + ++M +S + E Q I+ ++ + T ++N
Sbjct: 1210 E-QEISQLKKEIERTQQRMKEM-ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHT 1267
Query: 912 ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL----LSETLSLEKKEMSSIISLNKR 967
EL + Q EI+ L ++ KE L+E L K + + + +
Sbjct: 1268 ELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQA 1327
Query: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANY---IDEREKSISELSDQYKQEKLI 1024
EI++L+ E +LKE M +I E+ A + D ++ S+ +L++Q ++ KL
Sbjct: 1328 EIKKLSAEVESLKE------AYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE 1381
Query: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
L + + N ++ + + + + N L
Sbjct: 1382 LEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 154 bits (388), Expect = 2e-36
Identities = 326/1461 (22%), Positives = 598/1461 (40%), Gaps = 235/1461 (16%)
Query: 1239 QTIRGDLETSNLQDMQSQEIS----GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ 1294
+ +RG L + ++ QS S L + E + + Y E S N A L+ L+
Sbjct: 90 ERVRGFLTQTRVRSAQSPGGSLPSDDLGEMESSSSDYYNKDNEEESLLANV-ASLRHELK 148
Query: 1295 TTMNKLNEL-EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353
T L L E++ + +E + N SRSE KL+ +V+
Sbjct: 149 ITEWSLQSLGEELSSVSPSENSDYAP--NPSRSE-------------KLILDVQ--PSHP 191
Query: 1354 GLLHGELVEDI-----PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK--EVQMHFAE 1406
GLL+ E++ +F ++P ++ S AP+D+ E +L +K +++ A
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQ----EIKSLREKLNKLRQQNAC 247
Query: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL-VKEMQ 1465
L + SL ++ + +H + Q +K+S L++ A +L + N + ++ ++
Sbjct: 248 LVTQNHSLMTKFESIHFELTQSRAKVSMLES-AQQQAASVPILEEQIINLEAEVSAQDKV 306
Query: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA--LLEQT--GDMSLLSNLEGAVSANQC 1521
L E + + SL + LLEQT G + E +A +
Sbjct: 307 LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 1522 S----------VDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM- 1570
S +++ +EE L R T K + L+ C +Y+ LE L+EK+
Sbjct: 367 SKAFQQYKKKVAEKLEKVQAEEEILERNLTNCE--KENKRLQERCGLYKSELEILKEKLR 424
Query: 1571 ----------ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQK--LTSVTL 1618
E IM K + + QL S RQ + L + +++E + K L +
Sbjct: 425 QLKEENNNGKEKLRIMAVKNSEVMAQLTES-RQSILKLESELENKDEILRDKFSLMNENR 483
Query: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLS------SRSLLGIDT------------ 1660
E++ ++AA+ ++ + E+E +R++L+ L+ R L G +
Sbjct: 484 ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN 543
Query: 1661 -EDAIQGRNES----------------CDISKEHTSETTERTPKHDVHQICDKDAQQDLN 1703
ED G E+ +I K H + T + + I D+Q+
Sbjct: 544 KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQS---LITCNDSQESSK 600
Query: 1704 LDIEKITETGAVKPTGECSGEQSPDTN-------YEPPGEDKTQGSSECISELSFSGPNA 1756
L ET VK G E D N YE + G E ++L
Sbjct: 601 LSS---LETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLI------ 651
Query: 1757 LVPMDFLGNQEDIHNLQLRVK---ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL 1813
Q + N L+V TS L ++E L +EM + S+L
Sbjct: 652 ---------QIEAENSDLKVNMAHRTSQFQLIQEELLEKASNS-SKLESEMTKKCSQLLT 701
Query: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF----SCDHQELLQRVETSEGLNSD 1869
E QL KI A + EL++E + +EK+ + +H+++ E ++ ++
Sbjct: 702 LEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIH-- 759
Query: 1870 LEMHADKSSR-EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
LE H + + E + + K + +KE+ E +S ++ + +H +LE+ ++
Sbjct: 760 LEQHKEMEKQIERLEAQLEKKDQQFKEQ----EKTMSMLQQDIICKQH---HLESLDRLL 812
Query: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTA-LDQLSEKMKEK 1987
K ++K+N K + + L+ ++S T + QL L+ ++ L+QL E KEK
Sbjct: 813 TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL-EGNKEK 871
Query: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2047
++ +SE ++C+Q E+K K LQ S L Q+ LQ + L
Sbjct: 872 FEKQLKKKSEEVYCLQ---KELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGEL 928
Query: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107
T+ +LE Q+++L +E L K+ ES +L + + EK S A EA L K + + L
Sbjct: 929 EDTQTKLEKQVSKLEQE---LQKQRESSAEKLRKME-EKCE-SAAHEADL--KRQKVIEL 981
Query: 2108 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE 2167
+ T +V +IE D+ K E+L + E+E LK EN L +
Sbjct: 982 TGTARQV------------KIEMDQYK-----EELSKMEKEIMHLKRDGENKAMHLSQLD 1024
Query: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS 2227
+ILD +K E+E ++E+ + E +L ++E L ++Q G+L
Sbjct: 1025 -----MILD--QTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077
Query: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
+ L + +L++ A++ + EE T ++ L +L+E + E
Sbjct: 1078 STLRQLQELRDVLQK---AQLSL-EEKYTTIKDLTAELRECKMEI-------------ED 1120
Query: 2288 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347
+E + L+ +L+ R + + + E E L+G +E + ELE+
Sbjct: 1121 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE--KSELEL 1178
Query: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
N++ +E+L K++ + LR E ++ E L E+++ Q+R
Sbjct: 1179 KECNKQ------------IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 1226
Query: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467
+ E+E + E + + +E + + ++ E +Q EL E A H +A +
Sbjct: 1227 MKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAE---ARHQQVQAQREI 1283
Query: 2468 EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE--KKDEEIS 2525
E+ LSS ELE + L +A N++ + + + + + + + E K E+
Sbjct: 1284 ER-LSS-----ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE 1337
Query: 2526 RLK-----NQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580
LK I QE + + ++ N +L +ELE+ + + + +Q
Sbjct: 1338 SLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQ 1397
Query: 2581 DTLEVLQSSYKNLENELELTK 2601
D EV++++ NE LTK
Sbjct: 1398 DRNEVIEAA-----NEALLTK 1413
Score = 143 bits (360), Expect = 3e-33
Identities = 245/1212 (20%), Positives = 493/1212 (40%), Gaps = 182/1212 (15%)
Query: 251 EVTPSR---STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
E+T SR S L+ ++ A S +L ++ AQ++ LR N+LE +
Sbjct: 265 ELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLE-------QS 317
Query: 308 MKGQVNKFQELQLQLE---KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
K + K Q LQ E K KV+L+E+ K R E R A Y+ A A +Q
Sbjct: 318 QKMVIEKEQSLQESKEECIKLKVDLLEQTK--QGKRAERQRNEALYN-AEELSKAFQQYK 374
Query: 365 KKLTEDL---------------SCQRQNAE-SARCSLEQK----IKEKEKEFQEELSRQQ 404
KK+ E L +C+++N RC L + +KEK ++ +EE + +
Sbjct: 375 KKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGK 434
Query: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK------- 457
+ + + ++ A+LT+ Q + + L+ + D++ K L N E K
Sbjct: 435 EKLRIMAVKNSEVMAQLTESRQSILKLESELENK-DEILRDKFSLMNENRELKVRVAAQN 493
Query: 458 QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
++L +Q ++S+++ L + + ++ + L S ++ + C
Sbjct: 494 ERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCE 553
Query: 518 QSQNFAEEMKAKNTSQETMLRDLQEKINQQE-----------------NSLTLEKLKLAV 560
++ E++ K +E ++ L + + +SL E +KL
Sbjct: 554 ANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
Query: 561 ADL-EKQRDCSQDLLKKREHH--------IEQLNDKLSKTEKESKALLSALELKKKEY-- 609
+ E +D +Q + K+ IE+L KL + E E+ L + + ++
Sbjct: 614 HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
Query: 610 --EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI-NHLETCLKTQQIKSH--EYNER 664
EEL E+ + S +SE K +Q+ + ++ L+ KI + K +++ E NE+
Sbjct: 674 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEK 733
Query: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLK 724
+R+LE N++ E + + + +K + L+Q E +K+IE + +
Sbjct: 734 IRSLET---NINTE---------HEKICLAFEKAKKIHLEQHKEM-----EKQIERLEAQ 776
Query: 725 TSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL-----HAEYESLRDLLKSKDA-SLVTNE 778
+ Q ++ E + +L +I+ K + L ++ E ++ +K +A + N+
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
Query: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838
+ ++ A+ ++ + + + + + + LQ + S
Sbjct: 837 VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
Query: 839 LESQKQMNSDLQKQCEELVQI-------KGEIEENLMKAEQMHQSFVAETSQRISKLQED 891
L+ + N LQ ++ Q+ GE+E+ K E +++SKL+++
Sbjct: 897 LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLE-----------KQVSKLEQE 945
Query: 892 TSAHQNVVAETLSALENK----EKELQLLNDKV-------ETEQAEIQELKKSNHLLEDS 940
+ AE L +E K E L KV + E+ + K+ +E
Sbjct: 946 LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
Query: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
+ L+ E ++ ++ I+ K E+E+ T L+++ S E +QK E
Sbjct: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
Query: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC 1060
E + + EL +Q L + + A L +KY ++ L L EC
Sbjct: 1066 ET---ELQNAHGELKSTLRQ----LQELRDVLQKAQLSLEEKYTTIKD----LTAELREC 1114
Query: 1061 TSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
E++K EL ++ +A + + E + A ++ + +R + +
Sbjct: 1115 KMEIEDKKQELLEMDQALKERNWELKQRAA-----------QVTHLDMTIREHRGEMEQK 1163
Query: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMK-----VMKTKHECQNLESEPIR 1175
G L++ + LK E NK + +ND LQ ++ ++ +++ + E L+ E R
Sbjct: 1164 IIKLEGTLEKSELELK-ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIER 1222
Query: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
+ +E E + + + KE ++D +L ++N +L E+ ++ Q
Sbjct: 1223 TQQRMKEMESVMKEQEQYIATQYKE-AID-LGQELRLTREQVQNSHTELAEARHQQVQAQ 1280
Query: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPH---ELSTSQNDNAHLQCS 1292
E++ + +S L+DM+ ++EK G H EL S+ AHL+
Sbjct: 1281 REIERL-----SSELEDMKQL-----------SKEKDAHGNHLAEELGASKVREAHLEAR 1324
Query: 1293 LQTTMNKLN-ELEKICEILQAE---KYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348
+Q + KL+ E+E + E E E + S ++ +++ E++ K E++
Sbjct: 1325 MQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEE 1384
Query: 1349 LNDDSGLLHGEL 1360
D LH ++
Sbjct: 1385 AQDTVSNLHQQV 1396
Score = 142 bits (357), Expect = 7e-33
Identities = 295/1427 (20%), Positives = 577/1427 (40%), Gaps = 213/1427 (14%)
Query: 1037 EDLSQKYKAAQE---KNSKLECLLNECTSLCENRKN---ELEQLKEAFAKEHQEFLTKLA 1090
+DL + ++ + K+++ E LL SL K L+ L E + + A
Sbjct: 114 DDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYA 173
Query: 1091 FAEERNQNLMLELETVQQALRS------------EMTDNQNNSK----SEAGGLKQEIMT 1134
R++ L+L+++ L + TD Q + S + + QEI +
Sbjct: 174 PNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKS 233
Query: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM 1194
L+E+ NK++++ L+ +N LM TK E + E R V ES + Q P +
Sbjct: 234 LREKLNKLRQQNACLVTQNHSLM----TKFESIHFELTQSRAKVSMLESAQQQAASVPIL 289
Query: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK---EKECLQHELQTIRGDLETSNLQ 1251
+ ++ I+L+ A++ + +LR E KL++S+K EKE +LQ
Sbjct: 290 EEQI--INLE---AEVSAQDKVLREAENKLEQSQKMVIEKE---------------QSLQ 329
Query: 1252 DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE-LEKICEIL 1310
+ +E LK ++ ++ + + + + L + Q K+ E LEK+
Sbjct: 330 E-SKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKV---- 384
Query: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370
QAE+ L L + C +++ E G +E++IL + L E+ G E
Sbjct: 385 QAEEEILERNL----TNCEKENKRLQERCGLYKSELEILKEK---LRQLKEENNNGKEKL 437
Query: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS 1430
++ +A L ES + + + E++ L++KF SL +E++ L + +
Sbjct: 438 RIMAVKNSEVMAQLTESR--QSILKLESELENKDEILRDKF-SLMNENRELKVRVAAQNE 494
Query: 1431 KMSELQTYVDSLKAE---------NLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCV 1481
++ Q ++S + E L L L F+ L K Q+ C
Sbjct: 495 RLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSK-YQMSSFSNKEDRCIGCCE 553
Query: 1482 PDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEEN-LTRKE 1540
+ +S L + +++ L +NL +ANQ S + C+ QE + L+ E
Sbjct: 554 ANKLVISELR----IKLAIKEAEIQKLHANL----TANQLSQSLITCNDSQESSKLSSLE 605
Query: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600
T G + ES+ + + ++ K EK + + +E++ + +E +L
Sbjct: 606 TEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMA 665
Query: 1601 QYLSENEQWQQKL---TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLG 1657
S+ + Q++L S + ++ES++ KK ++ L+LE +L+ + + SS +
Sbjct: 666 HRTSQFQLIQEELLEKASNSSKLESEMT--KKCSQLLTLE---KQLEEKIVAYSSIAAKN 720
Query: 1658 IDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKP 1717
+ E + +NE K + ET T + +K + L E + ++
Sbjct: 721 AELEQELMEKNE-----KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEA 775
Query: 1718 TGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK 1777
E +Q + ++KT +++ D + Q + +L +
Sbjct: 776 QLEKKDQQFKE-------QEKTM---------------SMLQQDIICKQHHLESLDRLLT 813
Query: 1778 ET----SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVG 1833
E+ EN++ ++ +V ++++LDS L + K E + L ++ G
Sbjct: 814 ESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEI------CKEELVLHLNQLEG 867
Query: 1834 ELKKENSDLSEKLEYFSCDHQELLQR----VETSEG---LNSDLEMHADKSSREDIGDNV 1886
+K L +K E C +EL + ETSE L L+ +E I +
Sbjct: 868 NKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGE 927
Query: 1887 AKVNDSWKERFLD-VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE---NK 1942
+ + E+ + +E EL + R A ++ + E+ C +E +
Sbjct: 928 LEDTQTKLEKQVSKLEQELQKQRESSAE------------KLRKMEEKCESAAHEADLKR 975
Query: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
QKVI +T Q++ E+D ++ + +++ +K + H S+ +
Sbjct: 976 QKVI--------ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027
Query: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062
+ E+++KT ++ L +T L E LQ E L EL++ + QL
Sbjct: 1028 DQTKTELEKKTNAVKELEKLQH---STETELTEALQKREVLETELQNAHGELKSTLRQLQ 1084
Query: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
+ +++L K SL+ EK K L A E E + + ++E+ ++ + ++
Sbjct: 1085 ELRDVLQKAQLSLE--------EKYTTIKDLTA---ELRECKMEIEDKKQELLEMDQALK 1133
Query: 2123 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
+ ++ + H+ ++E E ++ K+ LE L+ SE L+ +
Sbjct: 1134 ERNWELKQRAAQVTHLDMTIREHRGE---MEQKIIKLEGTLEKSE-------LELKECNK 1183
Query: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
++E+L +++ L+ E ++ E L K+I+ Q ++ E++ ++ + +
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243
Query: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEA----------VAALCGDQEIMKATEQSLDPP 2292
+ + I + +E + E +QN EL EA + L + E MK + D
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303
Query: 2293 ----IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEH---------------HADL 2333
EE + L AR++A+ KK ++ LKE+ H AD
Sbjct: 1304 GNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADS 1363
Query: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
K V+ L +LE A+ E A N +V+ IE ++L
Sbjct: 1364 QKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 130 bits (327), Expect = 2e-29
Identities = 256/1318 (19%), Positives = 539/1318 (40%), Gaps = 187/1318 (14%)
Query: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
+EI+ L ++ L++ NA L + +L+ K ES + + +S L +Q + +
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
Query: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086
E+ N ++S + K +E +KLE + + ++ L++ KE K + L
Sbjct: 289 LE-EQIINLEAEVSAQDKVLREAENKLE----QSQKMVIEKEQSLQESKEECIKLKVDLL 343
Query: 1087 --TKLAFAEERNQNLML----ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN 1140
TK ER +N L EL Q + ++ + ++E L++ + ++E
Sbjct: 344 EQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENK 403
Query: 1141 KMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIR------NSVKERESERNQCNFKPQM 1194
++Q+ E E L + ++ E N E +R + V + +E Q K +
Sbjct: 404 RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463
Query: 1195 DLEVK-EISLDSYNAQLVQLEAMLRNKELKLQESEKEK--ECLQHELQTIRGDLETSNLQ 1251
+LE K EI D ++ M N+ELK++ + + + + Q E+++ R +E +L+
Sbjct: 464 ELENKDEILRDKFSL-------MNENRELKVRVAAQNERLDLCQQEIESSR--VELRSLE 514
Query: 1252 DMQSQ-----EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL--NELE 1304
+ SQ E+ G K Y+S S S ++ + C NKL +EL
Sbjct: 515 KIISQLPLKRELFGFKS--------YLSKYQMSSFSNKEDRCIGCC---EANKLVISELR 563
Query: 1305 KICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDI 1364
I +AE +L L ++ T ++E KL + L E V+ +
Sbjct: 564 IKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSS-----------LETEPVK-L 611
Query: 1365 PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424
G + E +Q+ ++ E +T EL+ K + +++E+ D
Sbjct: 612 GGHQVAESVKDQNQHTMNKQYEKERQRLVT--------GIEELRTKLIQIEAENS---DL 660
Query: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDS 1484
M+ + S+ Q ++ E L ++N + ++ K+ L L L V S
Sbjct: 661 KVNMAHRTSQFQL----IQEELLEKASNSSKLESEMTKKCSQLLT--LEKQLEEKIVAYS 714
Query: 1485 SSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSA 1544
S + ++ + L+E+ + +LE ++ E C + ++ E
Sbjct: 715 SIAAK--NAELEQELMEKN---EKIRSLETNINTEH----EKICLAFEKAKKIHLEQ--- 762
Query: 1545 PAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC------- 1597
+ +EK E++E+Q K+++ +E E+ +S +Q++ C
Sbjct: 763 ---------------HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLES 807
Query: 1598 ---LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVAR-------LQLQG 1647
L + E ++ K ++++++ E + QL LE+ + QL+G
Sbjct: 808 LDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEG 867
Query: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTP--KHDVHQICDKDAQQDLNLD 1705
L +E+ + + I ET+E+ +H + Q Q+ +
Sbjct: 868 NKEKFEKQLKKKSEE-VYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNG 926
Query: 1706 IEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGN 1765
+ T+T K + EQ E E + +C S + ++ G
Sbjct: 927 ELEDTQTKLEKQVSKL--EQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT 984
Query: 1766 QEDIH-NLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA 1824
+ + +E S ++H+ D + K L +LD L + +L K A
Sbjct: 985 ARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL----SQLDMILDQTKTELEKKTNA 1040
Query: 1825 CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGD 1884
ELEK+ + E ++ +K E + Q N+ E+ + +++ D
Sbjct: 1041 VKELEKLQHSTETELTEALQKREVLETELQ------------NAHGELKSTLRQLQELRD 1088
Query: 1885 NVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
+ K S +E++ +++ + +R K IE + E+++ ++ E++ E KQ+
Sbjct: 1089 VLQKAQLSLEEKYTTIKDLTAELRECKMEIE------DKKQELLEMDQALKERNWELKQR 1142
Query: 1945 VIVCLEEELSVVTSERNQLRGELD-TMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003
++++ + RGE++ + K L++ ++KE +++ES + +Q
Sbjct: 1143 AAQVTHLDMTI-----REHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDK----LQ 1193
Query: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
A+ +++EK ++ ++S+L K+ Q++++ +E + + L +
Sbjct: 1194 NAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
Query: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE- 2122
E L ++ ++ L+E+ ++++ + +E RLSS E++ QL + +
Sbjct: 1254 ELRLTREQVQNSHTELAEARHQQVQAQREIE-----------RLSSELEDMKQLSKEKDA 1302
Query: 2123 ---KLRVRIEADEKKQLHIAEK----LKERERENDSLKDKVENLERELQMSEENQELVIL 2175
L + A + ++ H+ + +K+ E +SLK E E+ +EN +
Sbjct: 1303 HGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLK---EAYHMEMISHQENHAKWKI 1359
Query: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLL 2233
A++ K+ V+ L Q+E+ +L+L + NL +Q+Q++ + ++ L
Sbjct: 1360 SADSQKSSVQQLNEQLEKA-------KLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 110 bits (276), Expect = 2e-23
Identities = 148/686 (21%), Positives = 291/686 (42%), Gaps = 71/686 (10%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQK--QKVENEKTEGTNLKRENQRLMEI 75
Q+ +E E + L+++ +Q L+SL+ L + K K EN K + +NQ +
Sbjct: 782 QQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ----V 837
Query: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
E K +Q + L++ + ++ QL K EK E++LK+ E+ Q+ +
Sbjct: 838 SEETIKVRQ-LDSALEICKEELVLHLNQLEGNK---EKFEKQLKKKSEEVYCLQKELKIK 893
Query: 136 DVSLNPCNTPQKIFTTPLTPSQYY------SGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
+ SL + I L Q + ED + K K+V +LE E LQ
Sbjct: 894 NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS---KLEQE---LQ 947
Query: 190 AKKASQTLPQATMNHR-DIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248
++ S M + + A H+A + + L+ +++ I D
Sbjct: 948 KQRESSAEKLRKMEEKCESAAHEADL------KRQKVIELTGTARQVKIEMD------QY 995
Query: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
++E++ + KRD + S +LDQ K + ++ N + ELE E E+
Sbjct: 996 KEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL 1055
Query: 309 KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLT 368
+ K + L+ +L+ A EL + L + RD L + ++ KYT ++ +L
Sbjct: 1056 TEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE---KYTTIKDLTAELR 1112
Query: 369 EDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT-------LDQECIQMKARL 421
E + ++ + ++Q +KE+ E ++ ++ T ++Q+ I+++ L
Sbjct: 1113 E-CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 1171
Query: 422 TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM 481
+ + K + +++ DKL + K+QL +++ + + SQ+K+ E+ R+
Sbjct: 1172 EKSELELKECNKQIESLNDKLQNAKEQLR------EKEFIMLQNEQEISQLKK-EIERTQ 1224
Query: 482 EEMKKENNLLKSHSEQKA---REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
+ MK+ +++K + A +E L EL+ ++ Q QN E+ Q R
Sbjct: 1225 QRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQR 1281
Query: 539 DLQEKINQQENSLTLEKLKLAVAD-LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
+++ ++ E+ L K K A + L ++ S K RE H+E ++ + E K
Sbjct: 1282 EIERLSSELEDMKQLSKEKDAHGNHLAEELGAS----KVREAHLE------ARMQAEIKK 1331
Query: 598 LLSALELKKKEYE-ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
L + +E K+ Y E+ + + WK + + ++ E L+ LE T
Sbjct: 1332 LSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSN 1391
Query: 657 KSHEYNERVRTLEMDRENLSVEIRNL 682
+ +R +E E L + N+
Sbjct: 1392 LHQQVQDRNEVIEAANEALLTKGENV 1417
Score = 77.8 bits (190), Expect = 2e-13
Identities = 109/545 (20%), Positives = 238/545 (43%), Gaps = 71/545 (13%)
Query: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK-----EKSSTAMEMLQ 2444
I+S +E L Q+ +++ + + FE+I E Q + ++ ++ + ++ +L+
Sbjct: 231 IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILE 290
Query: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Q+ L V+A Q+ + +N Q + + +EK Q LQ E+K I L+
Sbjct: 291 EQIINLEAEVSA----QDKVLREAENKLEQSQKMVIEKEQSLQ---ESKEECIKLKVD-- 341
Query: 2505 GLIQEVEDGKQKLEKKDEEI---SRLKNQIQDQEQLVS-KLSQVEGEHQLWKEQNLELRN 2560
L+++ + GK+ +++E + L Q ++ V+ KL +V+ E ++
Sbjct: 342 -LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI---------- 390
Query: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
LE+ + + +N LQ+ + +S + L+ +L K + + EK+ M K +E
Sbjct: 391 ----LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSE 446
Query: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE--EIKSS-KDQLKELTLENSELKKS 2677
+ ++ E Q +L+ EL + L + L+ E E+K Q + L L E++ S
Sbjct: 447 VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS 506
Query: 2678 -LDCMHKDQVEKEGKVREEI-------AEYQLRLHEAEKKHQALLLDTNKQY-------- 2721
++ +++ + ++ E+ ++YQ+ ++ + NK
Sbjct: 507 RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKL 566
Query: 2722 ---EVEIQTYREKLTSKE------ECLSSQK------LEIDLLKSSKEELNNSLKATTQ- 2765
E EIQ LT+ + C SQ+ LE + +K ++ S+K Q
Sbjct: 567 AIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQH 626
Query: 2766 -ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
+ ++ +K + + + +L+ + + + + L + + +++Q+EL L+ A
Sbjct: 627 TMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL--LEKASN 684
Query: 2825 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884
K + M K +L T K+L+E + + A + + L+ +EK+ + + T+
Sbjct: 685 SSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTE 744
Query: 2885 VAHLC 2889
+C
Sbjct: 745 HEKIC 749
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 180 bits (456), Expect = 2e-44
Identities = 266/1188 (22%), Positives = 508/1188 (42%), Gaps = 185/1188 (15%)
Query: 1795 RKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQ 1854
+++E L ++ + L +LH Q ++++ + +L +EN DLS KL F+ Q
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 1855 ELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
+L + LN E H+ K W E+ +E ELS A++
Sbjct: 336 QL------QDALNELTEEHS-------------KATQEWLEKQAQLEKELS------AAL 370
Query: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE-------L 1967
+ +K CLE+ NE Q + LEE LS + Q +GE L
Sbjct: 371 Q---------------DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
Query: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE--AEVKEKTELLQTLSSDVSE 2025
+T+ ++ L + +++ + + LE+ + + Q A+ AE E Q LSS +++
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQ-----QEAKLLAERGHFEEEKQQLSSLITD 470
Query: 2026 LLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYE 2085
L ++L + + LE+ SQA A+L + L E +L A + + D E
Sbjct: 471 LQSSISNLSQAKEELEQASQAHG----------ARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 2086 KLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK---- 2141
+ + A ++ + A L ++ LR +E+L ++ E++ +AEK
Sbjct: 521 LAGLK---QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 2142 -----------LKERE---RENDSLKDKVENLERELQMSEE--NQELVILDAENSKAEVE 2185
+ERE RE D+ ++E LE+E E Q+L + + A+
Sbjct: 578 RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637
Query: 2186 TLKTQIEEMARSLKVFELD--LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
+ Q E+ S KV EL + T R E+ Q+ E + QL + + + + +EK
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK 697
Query: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE----IMKATEQSLDPPIEEEHQL 2299
+Q + Q+ + K ++++ + L+E A +Q+ +KA +SL +E+ +
Sbjct: 698 DQLQEQL-QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL---VEQHKRE 753
Query: 2300 RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA 2359
R +E+ RA + E + LQQL E+ H A+ E L REL A Q A E
Sbjct: 754 RKELEEERAGRKGLEAR----LQQLGEA-HQAE-----TEVLRRELAEAMAAQHTAESEC 803
Query: 2360 ENSKGEVETLKAKIEGMTQSLRG----LELDVVTIRSEKENLTNELQKEQERISELEIIN 2415
E EV + + E Q + ++T++ E E ELQ+ +E+++ +E
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE--- 860
Query: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
S E + ++ E ++ + A++ Q++E R L +D + K S +V
Sbjct: 861 SHSELQISRQQNELAELHANLARALQ----QVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Query: 2476 ECLE--LEKAQLLQGLDEAKNNYIVLQSSVNGLIQ----EVEDGKQ------KLEKKDEE 2523
LE + KA Q E + +V + + G Q E + G+Q L+ + E
Sbjct: 917 ARLETLVRKAGEQQ---ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMERE 973
Query: 2524 ISRLKNQIQDQEQLVSKLSQVEGEHQLWK-EQNLELRNLTVELEQKIQVLQSKNAS---- 2578
++ N++ E+L + L + +G+ Q + +Q E+ LT E + L + A+
Sbjct: 974 AEQMGNEL---ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL 1030
Query: 2579 ---LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635
LQ+ L + + L+ L +K +++ K+ E +E+ E+ Q +L
Sbjct: 1031 EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQL 1090
Query: 2636 QEEL----------SGEKNRLAG-------ELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
+E+L SG ++ AG +L+ L E+ + Q ++ + L++SL
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL 1150
Query: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC 2738
+ + E++ + E + QL E H L + ++ E+ +R K+ +
Sbjct: 1151 EAERASRAERDSAL--ETLQGQLEEKAQELGHSQSALASAQR---ELAAFRTKVQDHSKA 1205
Query: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKK----ENERAQ-- 2792
K ++ + E N+ + + + + L + ++ +LK+ E+E++Q
Sbjct: 1206 EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL 1265
Query: 2793 -GKMKLL----IKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELK 2847
+++LL + + E L++E+ L+ EKQ+ + + ELT++ + +
Sbjct: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVAS--ENLRQELTSQAERAE 1323
Query: 2848 ETLEEKTKEADEYLDK---YCSLLISHEKLEK-AKEMLETQVAHLCSQ 2891
E +E +++ K +L + H + E+L + HLC Q
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK--HLCQQ 1369
Score = 174 bits (442), Expect = 9e-43
Identities = 313/1514 (20%), Positives = 618/1514 (40%), Gaps = 261/1514 (17%)
Query: 1500 LEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVY 1559
LE + LL+ + ++ Q +D + + L E+ P K +EEL E
Sbjct: 235 LELAENRKLLTEKDAQIAMMQQRIDRL--ALLNEKQAASPLEP----KELEELRDKNESL 288
Query: 1560 RQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE 1619
L + ++ + K++ +++ QL S E +L +++ S +Q Q L +T E
Sbjct: 289 TMRLHETLKQCQDLKTEKSQMDRKINQL-SEENGDLSFKLREFASHLQQLQDALNELTEE 347
Query: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679
++ QL EL A + L+ + + +QG+ + EH S
Sbjct: 348 HSKATQEWLEKQAQLEKELSAALQDKKCLE---------EKNEILQGKLSQLE---EHLS 395
Query: 1680 ETTERTPKH------DVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEP 1733
+ + P+ DV Q+ + Q+ L V+ G+Q E
Sbjct: 396 QLQDNPPQEKGEVLGDVLQL-ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 1734 PG-EDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIED 1792
E++ Q S I++L S N + L H +L +
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ--------------- 499
Query: 1793 RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCD 1852
V SL +E+ L++ + Q+ EL + + K++ + L++ L+
Sbjct: 500 ----VASLTSELTTLNATIQQQDQ----------ELAGLKQQAKEKQAQLAQTLQ----- 540
Query: 1853 HQELLQRVETSEGLNSDLE-MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEK 1911
Q+ + S+GL +E + + +E VA+ ++ ++ D +L+
Sbjct: 541 -----QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ---DHAQQLAT----- 587
Query: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971
A+ E EA E D + Q E LEK+ K ++ L+++L V R+ + +
Sbjct: 588 AAEEREASLRERDAALKQLE--ALEKEKAAKLEI---LQQQLQVANEARDSAQTSVTQAQ 642
Query: 1972 KKTTALDQLSEKMKE--KTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029
++ L + E+++ +T E H+++ QVAE E++ ++E Q +++ + ++
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQA----QVAELELQLRSE--QQKATEKERVAQE 696
Query: 2030 KTHLQEKLQSLEKDSQALSLTKCELENQ--------------IAQLNKEKELLVKESESL 2075
K LQE+LQ+L+ ++L +TK LE + I++L E LV++ +
Sbjct: 697 KDQLQEQLQALK---ESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753
Query: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI-EKLRVRIEADEKK 2134
+ L E + K LEA L + GE + Q E LRR + E + + A+ +
Sbjct: 754 RKELEEERAGR----KGLEARLQQLGE------AHQAETEVLRRELAEAMAAQHTAESEC 803
Query: 2135 QLHIAEKLKERERENDS-----------------LKDKVENLERELQMSEE-------NQ 2170
+ + E RER DS LK++ E +ELQ ++E +
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
Query: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS-EL 2229
EL I +N AE+ +AR+L+ + V + ++L+ +QEK S E+
Sbjct: 864 ELQISRQQNELAELHA------NLARALQQVQEKEVRAQKLADDLST-LQEKMAATSKEV 916
Query: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 2289
+L + + E++E A ++ +E A + L+E + C Q ++A E+
Sbjct: 917 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEE--QQGRQFCSTQAALQAMER-- 972
Query: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
E Q+ N +E+LRA L + +Q + E ++E E+AR
Sbjct: 973 -----EAEQMGNELERLRAALMESQGQQ-------------------QEERGQQEREVAR 1008
Query: 2350 TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR-------SEKENLTNELQ 2402
QE +A+ + + + ++ + +L ++ T++ +EKE EL
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMR-LQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067
Query: 2403 K----EQERISELEIINSSFENI---LQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVA 2455
K E +I ELE + + + + L +KE+E S A + +L A
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA 1127
Query: 2456 ALHNDQEACKAKEQNLSSQVECLELEKA---------QLLQG-LDEAKNNYIVLQSSVNG 2505
+ ++ C+ +++ S LE E+A + LQG L+E QS++
Sbjct: 1128 EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALAS 1187
Query: 2506 LIQEVEDGKQKLEKKDEEISRLKNQI----QDQEQLVSKLSQVEGEHQLWKEQNLELRNL 2561
+E+ + K++ + K Q+ Q+ E+ S +S +E E + Q LE
Sbjct: 1188 AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE 1247
Query: 2562 TVELEQKIQVLQSKNASLQDTLEVLQ----SSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
+ EL++ + K+ L++ L +LQ S+ + + S E+ K
Sbjct: 1248 SKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVA 1307
Query: 2618 ETELQREMHEMAQKTAELQEELSG------EKNRLAGELQL-------LLEEIKSSKDQL 2664
L++E+ A++ EL +EL +K + LQL L+ E+ +K
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
Query: 2665 KELTLENSELKKSLDCMHKDQVEKE----GKVREEIAEYQLRLHEAEKKHQALLLD--TN 2718
++L E + +K H++++E+ G +R E+ Q L E Q + T
Sbjct: 1368 QQLQAEQAAAEKR----HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 2719 KQYEVEIQTYREKLTSKEEC----------------LSSQKLEIDLLKSSKEELNNSLKA 2762
+Q E +Y E+L+ ++ L Q LE++L ++ ++ +
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
Query: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2822
L + + + +L+ + +G +++ ++ +EE++ L ++ QL+
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543
Query: 2823 QEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
Q +Q T +++EL + L + + + K ++ + ++ + L+
Sbjct: 1544 QREQ-------------TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
Query: 2883 TQVAHLCSQQSKQD 2896
Q+ L +Q S+++
Sbjct: 1591 AQLNELQAQLSQKE 1604
Score = 161 bits (407), Expect = 1e-38
Identities = 293/1422 (20%), Positives = 553/1422 (38%), Gaps = 174/1422 (12%)
Query: 277 PHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336
P L++L+ +N+ L +++E + Q + E K +L + +L E L
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 337 NKCRDELVRTTAQYDQAST----KYTALEQKLKKLTEDLSCQRQNAESARCSLEQ----- 387
+ +D L T ++ +A+ K LE++L +D C + E + L Q
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 388 -KIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK 446
++++ + + E+ +TL QE + A TQ LQA ++ L + +
Sbjct: 395 SQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQ-----------LQARVEMLETER 443
Query: 447 QQLENNL-------EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
Q E L EE KQ+L Q+S + L ++ EE+++ + ++H +
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSI---SNLSQAKEELEQAS---QAHGARLT 497
Query: 500 REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT--LEKLK 557
+V L +EL + + Q +K + ++ L ++ Q L +E+L
Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Query: 558 LAVADLEKQ-RDCSQDLLKKREHHIEQLNDKLSKTE---KESKALLSALELKKKE----Y 609
++ E+Q ++ ++ R+ H +QL + E +E A L LE +KE
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617
Query: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
E L+++ + + + + +TQ + EK L K+ L+ C++T + + HE +V LE
Sbjct: 618 EILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE 677
Query: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
+ + E QK +K + +K Q + + LK S L
Sbjct: 678 L-------------------QLRSEQQKAT-----EKERVAQEKDQLQEQLQALKES-LK 712
Query: 730 GQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ 789
LE + + ++ + ++ RC +L AE SL + K + L ++ L A Q
Sbjct: 713 VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQ 772
Query: 790 QPAMHHSFANII--GEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
Q H + E + + E +Q K A + R E S + + Q +
Sbjct: 773 QLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER---YEDSQQEEAQYGA 829
Query: 848 DLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE 907
Q+Q L + + + L +A++ + + +IS+ Q + + +A L ++
Sbjct: 830 MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ 889
Query: 908 NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR 967
KE Q L D + T Q ++ K LE +++ ET S E + R
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL--VKEPARAGDR 947
Query: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK----L 1023
+ E L ++ G S + +++E N ++ ++ E Q ++E+
Sbjct: 948 QPEWLEEQQG---RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER 1004
Query: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ 1083
+ + +E G A DL+ + A E +L+ LNE ++ E L+EA A
Sbjct: 1005 EVARLTQERGRAQADLALEKAARAELEMRLQNALNE-------QRVEFATLQEALAHALT 1057
Query: 1084 EFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ 1143
E +E + +L ++ A E+ + L+Q + LKE+ K +
Sbjct: 1058 E--------KEGKDQELAKLRGLEAAQIKELEE-----------LRQTVKQLKEQLAKKE 1098
Query: 1144 KE-VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS 1202
KE + ++E + T + + L +E + ++ + ++ Q + + LE + S
Sbjct: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAE-VSKLEQQCQKQQEQAD-SLERSLEAERAS 1156
Query: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL--QDMQSQEISG 1260
++ L L+ L K +L S+ Q EL R ++ + + ++Q G
Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG 1216
Query: 1261 LKDCE------IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314
++ E EE+ ++ + ++ L+ + K +LE+ +LQAE
Sbjct: 1217 RQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE- 1275
Query: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374
T N +R+ + + EEV L E + S L EL E
Sbjct: 1276 ----TASNSARA--AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE------ 1323
Query: 1375 EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSE 1434
E+ QEKF + L +H + +SE
Sbjct: 1324 ------------------------ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE 1359
Query: 1435 LQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSS 1494
L L A++L + +L + L + + L L
Sbjct: 1360 L------LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 1495 FYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVE-ELE 1553
A E+T E A A Q S+ + L EEN E + + +E EL+
Sbjct: 1414 QKVAEQERTAQQ---LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470
Query: 1554 SLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQ--- 1610
E Y Q L + E++ +E Q + L + + + + L E +++Q
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 1611 QKLTSVTLEMESKLAAEKKQTEQLSLEL----EVARLQLQGL 1648
QKLT+ ++E + KQ E+LS +L + +++Q Q L
Sbjct: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
Score = 159 bits (403), Expect = 3e-38
Identities = 328/1560 (21%), Positives = 636/1560 (40%), Gaps = 190/1560 (12%)
Query: 1499 LLEQTGDMSL--------LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVE 1550
L E+ GD+S L L+ A++ + L+++ KE SA + +
Sbjct: 316 LSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKEL-SAALQDKK 374
Query: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQ---YLSENE 1607
LE E+ + L +LEE + +++ QE ++L Q L+ L+++ + N
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQ---LQDNPPQEKGEVLGDVLQ-LETLKQEAATLAANNT 430
Query: 1608 QWQQKLTSVTLE---MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAI 1664
Q Q ++ + E E+KL AE+ E+ +L LQ +S+ S + E A
Sbjct: 431 QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS-SISNLSQAKEELEQAS 489
Query: 1665 QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE 1724
Q ++ + S T+E T + Q QQD E +K +
Sbjct: 490 QAHGAR--LTAQVASLTSELTTLNATIQ------QQD--------QELAGLKQQAKEKQA 533
Query: 1725 QSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI----HNLQLRVKETS 1780
Q T + E +QG + +LS S + + +++ H QL
Sbjct: 534 QLAQTLQQQ--EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENS 1840
E + +RD ++ L KE +KL + + QL EA + V + ++E +
Sbjct: 592 REAS-----LRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646
Query: 1841 DLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA-DKSSREDIGDNVAKVNDSWKERFLD 1899
+LS K+E + Q ++ ++LE+ + + + VA+ D +E+
Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706
Query: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSE 1959
++ L + K S+E E + ++ ++ C+ +E K + +E+ E
Sbjct: 707 LKESL---KVTKGSLEEEK---RRAADALEEQQRCI---SELKAETRSLVEQH----KRE 753
Query: 1960 RNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAE----VKEKTEL 2015
R +L E L QL E + +T+ L +E + AE+E VKE
Sbjct: 754 RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813
Query: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
+ E + QE+L +L+++ CE Q Q KEK ++ L
Sbjct: 814 RERYEDSQQEEAQYGAMFQEQLMTLKEE--------CEKARQELQEAKEKVAGIESHSEL 865
Query: 2076 QARLSESDYEKL--NVSKALEAAL---VEKGEFALRLSSTQEEVHQLRRGIEKLRVRI-E 2129
Q +++ +L N+++AL+ V + A LS+ QE++ + + +L + +
Sbjct: 866 QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK 925
Query: 2130 ADEKKQLHIAEKLKEREREND---------------SLKDKVENLEREL-QMSEENQELV 2173
A E+++ E +KE R D S + ++ +ERE QM E + L
Sbjct: 926 AGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLR 985
Query: 2174 ILDAENSKAEVETLKTQIEEMARSLKV---FELDLVTLRSEKENLTKQIQ----EKQGQL 2226
E+ + E Q E+AR + + DL ++ + L ++Q E++ +
Sbjct: 986 AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045
Query: 2227 SELDKLLSSFKSLLEEKEQ----------AEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
+ L + L+ + E K+Q A+I+ EE + V+ L+ QL + + A+
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Query: 2277 GDQ--------------EIMKAT----EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL 2318
G Q E ++A EQ E+ L S+E RA A+ L
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS-RAERDSAL 1164
Query: 2319 CVLQ-QLKESEHHADLLKGRVENLERELEIARTN-QEHAALEAE------NSKGEVETLK 2370
LQ QL+E + + + +REL RT Q+H+ E E + E E
Sbjct: 1165 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN 1224
Query: 2371 AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV 2430
+ I + + + L V+ E + L + E E+ +LE + E
Sbjct: 1225 SLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE---ERLRLLQAETASNSA 1281
Query: 2431 QMKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKE--QNLSSQVECLELEKAQLLQ 2487
+ E+SS E +Q+ +E +RVA+ + QE E + L +++ + + Q Q
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
L + + Q+ V+ L+ +Q ++ R + +++ +Q L
Sbjct: 1342 ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLR 1401
Query: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY-------------KNLE 2594
Q + + LR E E+ Q L+++ AS + L +L+ ++ NL
Sbjct: 1402 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG 1461
Query: 2595 NELELTKMDKM--SFVEKVNKMTA----KETELQREMHEMAQKTAELQEELSGEKNRLAG 2648
+ ++D+ +V+++ + A + E+QRE A++ + + G K ++
Sbjct: 1462 RQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE 1521
Query: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKE--GKVREE-IAEYQLRLHE 2705
E Q EE + Q+++L + E K ++ + K + + KV+++ + Q + E
Sbjct: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581
Query: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS---SKEELNNSLKA 2762
++++ Q L + ++ + +L+ KE+ KL+++ K+ +K++ N L+
Sbjct: 1582 SQQEAQRL--------QAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQE 1633
Query: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2822
+ LE+L+K + +L E ++A K K ++C+ L + L+ +++ A
Sbjct: 1634 QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA--HAD 1691
Query: 2823 QEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHE--KLEKAKEM 2880
Q+ + G D L + + K L+ D ++ L I+ + + +
Sbjct: 1692 QQLRDLGK-FQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTS 1750
Query: 2881 LETQVAHLCSQQ--SKQDSRGSPLLGPV-----VPGPSPIPSVTEKRLSSGQNKASGKRQ 2933
+ + A SQ+ K +S S P+ P S + S+ + L SG+ S +R+
Sbjct: 1751 VPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRR 1810
Score = 159 bits (402), Expect = 4e-38
Identities = 340/1747 (19%), Positives = 682/1747 (39%), Gaps = 266/1747 (15%)
Query: 694 ETQKLAYMELQQKAEF------SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL----- 742
E Q++ + ++ +F ++KH E + L G +L LL
Sbjct: 48 EGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHST 107
Query: 743 --SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
S D ++ + AE + + + L NED + L Q+ + + ++
Sbjct: 108 MSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFL----QKAPVPSTCSST 163
Query: 801 IGEQGSMPSERS-------ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
E+ S PS ++ E + A S N+ + + + L++ + L+KQ
Sbjct: 164 FPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQL 223
Query: 854 EELVQIKGEIEENLMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
+ + E+E L + ++ + +A QRI +L ++ E +A +
Sbjct: 224 ADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA--------LLNEKQAASPLEP 275
Query: 911 KELQLLNDKVETEQAEI-------QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIIS 963
KEL+ L DK E+ + Q+LK ++ + +L + LS + +E +S +
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 964 LNKREIEELTQENGTL------------KEINASLNQEKMNLIQKSESFANYIDEREKSI 1011
+ + ELT+E+ KE++A+L Q+K L +K+E + + E+ +
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAAL-QDKKCLEEKNEILQGKLSQLEEHL 394
Query: 1012 SELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL 1071
S+L D QEK +L + E L Q+ N++L+ + + ++ +L
Sbjct: 395 SQLQDNPPQEKGEVLGDVLQL----ETLKQEAATLAANNTQLQARVEMLETERGQQEAKL 450
Query: 1072 EQLKEAFAKEHQEFLTKLAFAEERNQNLML---ELETVQQALRSEMTDNQNNSKSEAGGL 1128
+ F +E Q+ + + + NL ELE QA + +T + SE L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 1129 K-------QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES------EPIR 1175
QE+ LK++ + Q ++ LQ+ EQ + ++ H+ + L S + ++
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR--HQVEQLSSSLKQKEQQLK 568
Query: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
+++E+ R + E +E SL +A L QLEA+ + K KL E LQ
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL-------EILQ 621
Query: 1236 HELQTI---RGDLETSNLQDMQ-----SQEISGLKDCEIDAEEKYISGPHELSTSQNDNA 1287
+LQ R +TS Q + S+++ L+ C A ++ HE +Q A
Sbjct: 622 QQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ----HE---AQAQVA 674
Query: 1288 HLQCSLQTTMNKLNELEKIC-------EILQAEKYEL-VTE--LNDSRSECITATRKMAE 1337
L+ L++ K E E++ E LQA K L VT+ L + + A +
Sbjct: 675 ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Query: 1338 EVGKLLNEVKILNDDSGLLHGELVEDIPGG--------EFGEQPNEQHPVSLAPLDESNS 1389
+ +L E + L + EL E+ G + GE + V L E+ +
Sbjct: 735 CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 1390 YEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSE-LQTYVDSLKAENLV 1448
+H S+ E +L ++ + + ++ + Q + E L T + +
Sbjct: 795 AQHTAESECE------QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 1449 LSTNLRNFQG-DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMS 1507
L G + E+Q+ ++ + L ++ + +L + + L D+S
Sbjct: 849 LQEAKEKVAGIESHSELQISRQQNELAELHANL---ARALQQVQEKEVRAQKLAD--DLS 903
Query: 1508 LLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE 1567
L A S ++ + + +++ +E PA+ + + E LE
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD----------RQPEWLE 953
Query: 1568 EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ----------KLTSVT 1617
E+ Q +Q +E+ EL+ LR + Q Q+ +LT
Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQER 1013
Query: 1618 LEMESKLAAEKKQTEQLSLELEVA----RLQLQGL-DLSSRSLLGIDTEDAIQGRNESCD 1672
++ LA EK +L + L+ A R++ L + + +L + +D + +
Sbjct: 1014 GRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073
Query: 1673 ISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTG------------- 1719
++ E +T K Q+ K+ + + G +PTG
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS-EAAGRTEPTGPKLEALRAEVSKL 1132
Query: 1720 --ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGN--------QEDI 1769
+C +Q + E E + +E S L LG+ Q ++
Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
Query: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
+ +V++ S + ++ E + + L+ ++ + Q++ K EL+
Sbjct: 1193 AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
Query: 1830 KIVGELKKENSDLSEKLEYFSCDH------------------QELLQRVE----TSEGLN 1867
++V +++ L E+L + Q L + E SE L
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR 1312
Query: 1868 SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE---HEALYLEAD 1924
+L A+++ E++G + +W+E+F E LS ++ E S + E L +
Sbjct: 1313 QELTSQAERA--EELGQELK----AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 1925 LEVVQTEKLCLEKDN-----ENKQKV----------------IVCLEEELSVVTSERNQL 1963
+ +Q E+ EK + ++KQ ++ L ++++ QL
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQL 1426
Query: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEK--TELLQTLSS 2021
R E + +++ + L + + E+ + L + ++V + +EK EL +
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
Query: 2022 DVSELLKDKTHLQEKLQSLE--------------KDSQALSLTKCELENQIAQLNKEKEL 2067
+ L + + Q + LE ++ Q + +L Q+ QL +
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
K+ E L +L++SD + L+A + GE +Q+E +L+ + +L+ +
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE-------SQQEAQRLQAQLNELQAQ 1599
Query: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLEREL----QMSEENQELVILDAENSKAE 2183
+ E+ H ++++ + D+ K + + L+ +L Q+ +EN+EL +AE
Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKEL--------RAE 1651
Query: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
E L ++++ K E L ++ +L Q+ QL +L K + +L +
Sbjct: 1652 AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
Query: 2244 EQAEIQI 2250
QA+ Q+
Sbjct: 1712 PQAKPQL 1718
Score = 157 bits (396), Expect = 2e-37
Identities = 366/1765 (20%), Positives = 697/1765 (39%), Gaps = 256/1765 (14%)
Query: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQ--SQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
L S Q RE+ LE + N S + A M + + +R L++++ +
Sbjct: 168 LSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADER 227
Query: 549 NSLTLEKLKLAVADLEK---QRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
++ ++L+L +A+ K ++D ++++R + LN+K + A L+
Sbjct: 228 SNR--DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQA-----------ASPLE 274
Query: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV 665
KE EEL+++ + E K +++EK + KIN L K E+ +
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 666 RTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKT 725
+ L+ L+ E SK+ + +K A +E + A D+K +E K
Sbjct: 335 QQLQDALNELTEE--------HSKATQEWLEKQAQLEKELSAALQDKKCLEE------KN 380
Query: 726 SQLTGQVEDL-EHKLQLLSNEIMDKDRCYQDLHAEYESLRD----------LLKSKDASL 774
L G++ L EH QL N +K D+ + E+L+ L+++ L
Sbjct: 381 EILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQLQARVEML 439
Query: 775 VTNEDHQRSLLAFDQQ--PAMHHSFANIIGEQGSMPSERSECRLEADQ-SPKNSAILQNR 831
T Q + L ++ +++I + S S S+ + E +Q S + A L +
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED 891
V SL L + +N+ +Q+Q +EL +K + +E A+ +Q + + ++
Sbjct: 500 VASLTSELTT---LNATIQQQDQELAGLKQQAKEK-----------QAQLAQTLQQQEQA 545
Query: 892 TSAHQNVVAETLSALENKEKELQLLNDKVE-TEQAEIQELKKSNHLLEDSLKELQLLSET 950
+ ++ V + S+L+ KE++L+ + +K E T Q Q+L + E SL+E +
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605
Query: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID----- 1005
L +KE ++ + + +++++ + + + +EK L +K E ++
Sbjct: 606 LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 1006 --EREKSISEL-----SDQYK--------QEKLIL---LQRCEET-----GNAYEDLSQK 1042
E + ++EL S+Q K QEK L LQ +E+ G+ E+ +
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
Query: 1043 YKAAQEKNSKLECLLNECTSLCENRKNELEQLKE--AFAKEHQEFLTKLAFAEERNQNLM 1100
A +E+ + L E SL E K E ++L+E A K + L +L A +
Sbjct: 726 ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ------ 779
Query: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE-QNKMQKEVNDLLQENEQLMKV 1159
E E +++ L M Q+ ++SE L +E+ +E ++ Q+E EQLM +
Sbjct: 780 AETEVLRRELAEAMA-AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTL 838
Query: 1160 MKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRN 1219
K EC E R ++E + + ++ + ++ L +A L + ++
Sbjct: 839 ---KEEC-----EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 1220 KELKLQESEKEKECLQHELQTIRGD---LETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
KE++ Q+ + LQ ++ + LET + + QE + + +E +G
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRE----LVKEPARAGD 946
Query: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
+ + CS Q + + ++ E ++ EL R+ + + +
Sbjct: 947 RQPEWLEEQQGRQFCSTQAAL----------QAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 1337 EEVGKLLNEVKILNDDSGLLHGEL-VEDIPGGE----FGEQPNEQHPVSLAPLDESNSYE 1391
EE G+ EV L + G +L +E E NEQ V A L E+ ++
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQR-VEFATLQEALAH- 1054
Query: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
L++KE E L ++ EL+ V LK + +
Sbjct: 1055 --ALTEKE-------------GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ--LAKK 1097
Query: 1452 NLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSN 1511
+ G + G E P L + + +S L + EQ +
Sbjct: 1098 EKEHASGSGAQSEAAGRTEPTGPKLEAL----RAEVSKLEQQC--QKQQEQADSLERSLE 1151
Query: 1512 LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME 1571
E A A + S E L+E+ + SA A EL + Q K E++ +
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF-RTKVQDHSKAEDEWK 1210
Query: 1572 SQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT 1631
+Q +E + L+SS +E+ L +Q L + + + E++ + AE +++
Sbjct: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE--------SKELKRLVMAESEKS 1262
Query: 1632 EQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
++L RL+L + +S S + A+ +E E K
Sbjct: 1263 QKLE-----ERLRLLQAETASNSARAAERSSAL----------REEVQSLREEAEK---Q 1304
Query: 1692 QICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSF 1751
++ ++ +Q+L E+ E G ++ K Q S +L
Sbjct: 1305 RVASENLRQELTSQAERAEELGQELKA------------WQEKFFQKEQALSTL--QLEH 1350
Query: 1752 SGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL 1811
+ ALV + L + LQ E + R +E + L E+ +L
Sbjct: 1351 TSTQALV-SELLPAKHLCQQLQ---AEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL 1406
Query: 1812 HLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSD-- 1869
+L+ + E E+ +L+ E + +E+L H L E + GL
Sbjct: 1407 G----ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL---AEENRGLGERAN 1459
Query: 1870 -----LEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEAD 1924
LE+ D+ +RE +A V D E L+ ++ E S E + A
Sbjct: 1460 LGRQFLEVELDQ-AREKYVQELAAVR-------ADAETRLAEVQREAQSTARELEVMTAK 1511
Query: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984
E + + L + + +++ + E+L V E+ + +++ +SKK DQ S+
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK---QVEELSKKLADSDQASKVQ 1568
Query: 1985 KEKTQELESHQSECLHCIQVAEAEVKEKTELL----QTLSSDVSELLKDKTHLQ-EKLQS 2039
++K + +++ E Q +A++ E L Q ++ K KTH +K Q+
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN 1628
Query: 2040 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS---KALEA- 2095
E Q SL + + EN+ +L E E L E + + E++ +++ ++LEA
Sbjct: 1629 QELQEQLRSLEQLQKENK--ELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
Query: 2096 ------ALVEKGEFALRLSSTQEEVHQLRRGIEKL--RVRIEADEKKQLHIAEKLKERER 2147
L + G+F + + + Q + ++ + + +E L I KL +
Sbjct: 1687 VAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQP 1746
Query: 2148 ENDS------------LKDKVENLE 2160
+ S L KVE+LE
Sbjct: 1747 DGTSVPGEPASPISQRLPPKVESLE 1771
Score = 152 bits (384), Expect = 5e-36
Identities = 360/1773 (20%), Positives = 712/1773 (40%), Gaps = 262/1773 (14%)
Query: 981 EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE-KLILLQRCEETGNAYEDL 1039
E +LN++ N +QK+ + + +S S Q K+E + + LQ+ + + L
Sbjct: 138 EDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFL 197
Query: 1040 SQ--------------------KYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
S K + A E++++ E L L ENRK E K+A
Sbjct: 198 SGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELE----LAENRKLLTE--KDAQI 251
Query: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Q+ + +LA E+ LE + ++ E+ D + ++ LK E+
Sbjct: 252 AMMQQRIDRLALLNEKQAASPLEPKELE-----ELRDKNESLTMRLHETLKQCQDLKTEK 306
Query: 1140 NKMQKEVNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEV 1198
++M +++N L +EN L K+ + Q L+ N + E S+ Q + Q LE
Sbjct: 307 SQMDRKINQLSEENGDLSFKLREFASHLQQLQDA--LNELTEEHSKATQEWLEKQAQLEK 364
Query: 1199 KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEI 1258
+ L + ++K+CL+ + + ++G L S L++ SQ
Sbjct: 365 E------------------------LSAALQDKKCLEEKNEILQGKL--SQLEEHLSQ-- 396
Query: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
L+D + + + +L T + + A L + +L+ E+L+ E+ +
Sbjct: 397 --LQDNPPQEKGEVLGDVLQLETLKQEAATLAANN-------TQLQARVEMLETERGQQE 447
Query: 1319 TELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
+L R ++++ + L + + L+ L EQ ++ H
Sbjct: 448 AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL--------------EQASQAHG 493
Query: 1379 VSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTY 1438
L S + E TL+ A +Q++ L + ++ Q++ + + +
Sbjct: 494 ARLTAQVASLTSELTTLN--------ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
Query: 1439 VDSLKAENLVLSTNLRNFQGDL--VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
L+ + LS++L+ + L V E Q + L+++ +SL +
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605
Query: 1497 RALLEQTGDMSL---LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELE 1553
LE+ L L+ A A + V + ++ L+RK VEEL+
Sbjct: 606 LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK---------VEELQ 656
Query: 1554 SLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKL 1613
+ E RQ E+ E+Q ++ ELE L SE+Q+ +++ E +Q Q++L
Sbjct: 657 ACVETARQ------EQHEAQA-----QVAELELQLRSEQQKAT-EKERVAQEKDQLQEQL 704
Query: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI 1673
++ ++ + +++ + + LE + + L +RSL+ Q + E
Sbjct: 705 QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE-------QHKRER--- 754
Query: 1674 SKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDT---- 1729
KE E R Q + Q + + ++ E A + T E EQ
Sbjct: 755 -KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAW 813
Query: 1730 --NYEPPGEDKTQGSSECISEL-SFSGPNALVPMDFLGNQEDIHNLQ----LRVKETSNE 1782
YE +++ Q + +L + + +E + ++ L++ NE
Sbjct: 814 RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873
Query: 1783 ------NL-RLLHVIEDRDRKVESLLNEMKELDSKLHL---QEVQLMTKIEACIELEKIV 1832
NL R L +++++ + + L +++ L K+ + +L T + E ++
Sbjct: 874 LAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
Query: 1833 G-ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
EL KE + ++ E L+ + + ++ + A + E +G+ + ++
Sbjct: 934 SRELVKEPARAGDR-------QPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLE---KDNENKQKV-IV 1947
+ E + E + E A + E +ADL + + + LE ++ N+Q+V
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 1948 CLEEELSVVTSERN-------QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000
L+E L+ +E+ +LRG K+ L Q +++KE+ + E +
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 2001 CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQ 2060
A + L+ L ++VS+L + QE+ SLE+ +A ++ E ++ +
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL-- 1164
Query: 2061 LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL---SSTQEE---- 2113
E+LQ +L E E + AL +A E F ++ S ++E
Sbjct: 1165 ------------ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQ 1212
Query: 2114 VHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV 2173
V + R+ E+ I + E++ + ++ E+E E+ LK V + Q EE L+
Sbjct: 1213 VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLL 1272
Query: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLL 2233
+ ++ A + + E +SL+ + R ENL +++ + + EL + L
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLRE---EAEKQRVASENLRQELTSQAERAEELGQEL 1329
Query: 2234 SSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI 2293
+++ +KEQA ++ E T+ + L ++L L +Q A E+ +
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQA---AAEKRHREEL 1385
Query: 2294 EEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
E+ Q + E LRA+ E E L Q++ E E A L+ + +L + +
Sbjct: 1386 EQSKQAAGGLRAELLRAQRELGELIPL--RQKVAEQERTAQQLRAEKASYAEQLSMLK-- 1441
Query: 2352 QEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL------QKEQ 2405
+ H L EN RGL E+ NL + Q +
Sbjct: 1442 KAHGLLAEEN-------------------RGL--------GERANLGRQFLEVELDQARE 1474
Query: 2406 ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
+ + EL + + E L E + +E STA E+ K +V L +++ +
Sbjct: 1475 KYVQELAAVRADAETRLAEVQ------REAQSTARELEVMTAKYEGAKVKVLE-ERQRFQ 1527
Query: 2466 AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS 2525
+ Q L++QVE LE+ + + + ++E + Q+++ + + + +E
Sbjct: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
Query: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
RL+ Q+ +L ++LSQ E Q + L++ + K Q Q L+ +LE
Sbjct: 1588 RLQAQL---NELQAQLSQKE---QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR-SLEQ 1640
Query: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ-KTAELQEELSGEKN 2644
LQ K L E E ++ + + KE E Q H AQ ++ E Q + ++
Sbjct: 1641 LQKENKELRAEAE-----RLGHELQQAGLKTKEAE-QTCRHLTAQVRSLEAQVAHADQQL 1694
Query: 2645 RLAGELQLLLEEIKSSKDQLK---ELTLENSEL 2674
R G+ Q+ + +KS + Q K +L++++ +L
Sbjct: 1695 RDLGKFQVATDALKSREPQAKPQLDLSIDSLDL 1727
Score = 147 bits (371), Expect = 2e-34
Identities = 251/1283 (19%), Positives = 532/1283 (41%), Gaps = 154/1283 (12%)
Query: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE----GTNLKRENQRLMEI 75
IQ+ + +L LK++ +++Q QL LQ+Q+Q + + + ++LK++ Q+L E+
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQ---TLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
E E T+Q + +L + + ++ KQ+E LE+E K K E+ + Q
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE-KAAKLEILQQQ------ 623
Query: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQ 195
L N + T +T +Q E+ L +V+ LQA +
Sbjct: 624 ---LQVANEARDSAQTSVTQAQ------------------REKAELSRKVEELQA--CVE 660
Query: 196 TLPQATMNHRDIARHQASSSVFSWQ-QEKTPSHLSSNSQRTPIRRDFSASYFSG-EQEVT 253
T Q +H+A + V + Q ++ ++ +R +D ++ +
Sbjct: 661 TARQ--------EQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712
Query: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
++ +L+ KR A + + +LKA+ + L + L+ KG
Sbjct: 713 VTKGSLEEEKRRAADAL---EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 314 KFQEL----QLQLEKAKVELIE----KEKVLNKCRDELVRTTAQY-------DQASTKYT 358
+ Q+L Q + E + EL E + ++C ++LV+ A + Q +Y
Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC-EQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 359 AL-EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417
A+ +++L L E+ RQ + A+ +K+ E + ++SRQQ E ++
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAK----EKVAGIESHSELQISRQQ-------NELAEL 877
Query: 418 KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL 477
A L + LQQ + Q D L+++++++ +E + +A + + EL
Sbjct: 878 HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937
Query: 478 RRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
+ E + + + EQ+ R+ C +A L+ +++ Q N E ++A +
Sbjct: 938 VK--EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ 995
Query: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
++ + + ++ LT E+ + A ADL ++ +L + ++ LN++ + +A
Sbjct: 996 QEERGQQEREVARLTQERGR-AQADLALEKAARAELEMRLQN---ALNEQRVEFATLQEA 1051
Query: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI- 656
L AL K+ + +EL + + L + E E+L ++ KE L K + Q
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 657 --KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
++ ++ L + L + + DS +E ++ + E E
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE----TL 1167
Query: 715 QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Q ++E + + + +L ++ D + + A+ R + K+ SL
Sbjct: 1168 QGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN-SL 1226
Query: 775 VTNEDHQRSLL---AFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
+++ + + S+L +++ ++ E RL ++ NSA R
Sbjct: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
Query: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA------ETSQRI 885
+L E + + + +KQ ++ E+ +AE++ Q A + Q +
Sbjct: 1287 SSALR---EEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343
Query: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH----LLEDSL 941
S LQ + ++ Q +V+E L A K QL ++ E+ +EL++S L + L
Sbjct: 1344 STLQLEHTSTQALVSELLPA---KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Query: 942 KELQLLSETLSLEKK--EMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES 999
+ + L E + L +K E + E ++ LK+ + L +E L +++
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 1000 FANYID-----EREKSISELS--DQYKQEKLILLQR-CEETGNAYEDLSQKYKAAQEKNS 1051
+++ REK + EL+ + +L +QR + T E ++ KY+ A+ K
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR 1111
+ E + +LE + K+ +E KLA +++ ++ +L+ VQ
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ---- 1576
Query: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL---MKVMKTKHECQN 1168
++ G +QE L+ + N++Q +++ Q E M+ KT ++ +
Sbjct: 1577 -----------AQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625
Query: 1169 LESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESE 1228
+++ ++ ++ E Q+ E KE+ A+ +L L+ LK +E+E
Sbjct: 1626 QQNQELQEQLRSLE----------QLQKENKEL-----RAEAERLGHELQQAGLKTKEAE 1670
Query: 1229 KEKECLQHELQTIRGDLETSNLQ 1251
+ L +++++ + ++ Q
Sbjct: 1671 QTCRHLTAQVRSLEAQVAHADQQ 1693
Score = 134 bits (337), Expect = 1e-30
Identities = 236/1228 (19%), Positives = 483/1228 (39%), Gaps = 192/1228 (15%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
+K++EL+ ++ ++E+ + Q Q+ LE L+ ++QK ++ + ++L + E
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
SL+ TK + E + + Q+ ++ K + L ++ KR + ELE + + +
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
L + L E + E E +R AE A Q S+
Sbjct: 770 RL-------------------------QQLGEAHQAETEVLRRELAEAMAAQHTAESEC- 803
Query: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Q V +W++ + S + F + ++E +R
Sbjct: 804 ------------EQLVKEVAAWRER----YEDSQQEEAQYGAMFQEQLMTLKEECEKARQ 847
Query: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQG-HEKEMKGQ--VNK 314
LQ K H Q+ Q EL L LQ EKE++ Q +
Sbjct: 848 ELQEAKEKV------AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901
Query: 315 FQELQLQLEKAKVELIEKEKVLNKCRD-------ELVRTTAQYDQASTKYTALEQKLKKL 367
LQ ++ E+ E ++ K + ELV+ A+ ++ +Q +
Sbjct: 902 LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFC 961
Query: 368 TEDLSCQRQNAESARCS-----LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT 422
+ + Q E+ + L + E + + QEE +Q+R L QE + +A L
Sbjct: 962 STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA 1021
Query: 423 QE----LQQAKNMHNVLQAELDKLTSVKQQLENNL--EEFKQKLCRAEQAFQASQIKE-N 475
E + + N L + + ++++ L + L +E K + + +A+QIKE
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
Query: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQET 535
ELR++++++K++ L K E + EA + + E ++A+ + E
Sbjct: 1082 ELRQTVKQLKEQ--LAKKEKEHASGSGAQSEAAGRT-----EPTGPKLEALRAEVSKLEQ 1134
Query: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKES 595
+ QE+ + E SL E+ A D + Q L+++ + L+ ++E
Sbjct: 1135 QCQKQQEQADSLERSLEAERASRAERD--SALETLQGQLEEKAQELGHSQSALASAQRE- 1191
Query: 596 KALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKEN-----LQSKINHLETC 650
L+A K +++ + ++E WK++ + + E+E++N L+ +++ L
Sbjct: 1192 ---LAAFRTKVQDHSKAEDE------WKAQVAR--GRQEAERKNSLISSLEEEVSILNRQ 1240
Query: 651 LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
+ ++ +S E V + L +R L S S + A E Q
Sbjct: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREE 1300
Query: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
+K + EN+ + + + E+L +L+ + K++ L E+ S + L+
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE- 1359
Query: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
+P++ +L+A+Q +A +
Sbjct: 1360 -----------------------------------LLPAKHLCQQLQAEQ----AAAEKR 1380
Query: 831 RVDSLEFSLESQKQMNSDL---QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
+ LE S ++ + ++L Q++ EL+ ++ ++ E A+Q+ AE + +
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR----AEKASYAEQ 1436
Query: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE---IQELKKSNHLLEDSLKEL 944
L AH + E E Q L +VE +QA +QEL E L E+
Sbjct: 1437 LSMLKKAHGLLAEENRGLGERANLGRQFL--EVELDQAREKYVQELAAVRADAETRLAEV 1494
Query: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
Q +++ + E + M++ K ++ E Q +E+ L + E +
Sbjct: 1495 QREAQSTARELEVMTAKYEGAKVKVLEERQR----------FQEERQKLTAQVEQLEVFQ 1544
Query: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA-------AQEKNSKLECLL 1057
E+ K + ELS ++ ++ A + QK KA +Q++ +L+ L
Sbjct: 1545 REQTKQVEELS-----------KKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL 1593
Query: 1058 NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDN 1117
NE + + ++ EQ E + + ++ T +++NQ L +L +++Q +
Sbjct: 1594 NE----LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ-----LQKE 1644
Query: 1118 QNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-MKVMKTKHECQNL-ESEPIR 1175
++EA L E+ + + ++ L + L +V + ++L + +
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT 1704
Query: 1176 NSVKERESERNQCNFKPQMDLEVKEISL 1203
+++K RE + KPQ+DL + + L
Sbjct: 1705 DALKSREPQA-----KPQLDLSIDSLDL 1727
Score = 132 bits (331), Expect = 7e-30
Identities = 191/835 (22%), Positives = 373/835 (44%), Gaps = 100/835 (11%)
Query: 2116 QLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2175
Q+RR ++L ++ +L +AE K ++ + + ++R L + E Q L
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR-LALLNEKQAASPL 273
Query: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
+ + E+E L+ + E + L L++EK + ++I + + +L L
Sbjct: 274 EPK----ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE 329
Query: 2236 FKSLLEEKEQAEIQIKEE-SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE 2294
F S L++ + A ++ EE SK E L+ Q +L + ++A D++ ++ + L +
Sbjct: 330 FASHLQQLQDALNELTEEHSKATQEWLEKQ-AQLEKELSAALQDKKCLEEKNEILQGKLS 388
Query: 2295 EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART--NQ 2352
QL + +L+ ++ + L + QL+ + A L L+ +E+ T Q
Sbjct: 389 ---QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 445
Query: 2353 EHAALEAENSKGEVE---------TLKAKIEGMTQSLRGLE-----------LDVVTIRS 2392
+ A L AE E E L++ I ++Q+ LE V ++ S
Sbjct: 446 QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 505
Query: 2393 EKENLTNELQKEQERISEL----EIINSSFENILQEKEQEKVQMK---EKSSTAMEMLQT 2445
E L +Q++ + ++ L + + LQ++EQ ++ E+ S++++ +
Sbjct: 506 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
Query: 2446 QLKELNERVAAL---HNDQEACKAKEQNLS--------SQVECLELEKAQLLQGLDEAKN 2494
QLKE+ E+ A H Q A A+E+ S Q+E LE EKA L+ L +
Sbjct: 566 QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625
Query: 2495 NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR-LKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
+ S + + + K +L +K EE+ ++ Q+Q + ++++++E
Sbjct: 626 VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE-------- 677
Query: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
L+LR+ + +K +V Q K+ LQ+ L+ L+ S K + LE K +E+ +
Sbjct: 678 --LQLRSEQQKATEKERVAQEKD-QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Query: 2614 MTAK---ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
++ ET E H+ +K EL+EE +G K L LQ L E ++ + L+
Sbjct: 735 CISELKAETRSLVEQHKRERK--ELEEERAGRKG-LEARLQQLGEAHQAETEVLRR---- 787
Query: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
EL +++ H + E E V+ E+A ++ R +++++ QY Q +
Sbjct: 788 --ELAEAMAAQHTAESECEQLVK-EVAAWRERYEDSQQE--------EAQYGAMFQ--EQ 834
Query: 2731 KLTSKEEC-LSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
+T KEEC + Q+L+ K + E ++ L+ + Q EL + + + + Q++++
Sbjct: 835 LMTLKEECEKARQELQEAKEKVAGIESHSELQISRQ-QNELAELHANLARALQQVQEKEV 893
Query: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849
RAQ L L+E+ KE+++L+ +K G +T EL E +
Sbjct: 894 RAQ----KLADDLSTLQEKMAATSKEVARLETL--VRKAGEQQETASRELVKEPARAGDR 947
Query: 2850 LEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLC-----SQQSKQDSRG 2899
E +E + ++CS + + +E+ E + ++ L SQ +Q+ RG
Sbjct: 948 QPEWLEE--QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG 1000
Score = 107 bits (266), Expect = 2e-22
Identities = 204/1006 (20%), Positives = 414/1006 (41%), Gaps = 176/1006 (17%)
Query: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV----ENEKTEGTNLKR--- 67
RALQ++QE E + KL + Q ++ + + + + V E ++T L +
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942
Query: 68 ----------ENQRLMEIC------ESLEKTKQKISHELQ-----VKESQVNFQEGQLNS 106
E Q+ + C +++E+ +++ +EL+ + ESQ QE +
Sbjct: 943 RAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE-ERGQ 1001
Query: 107 GKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYS------ 160
++++ +L QE R +++L + A ++ L Q++ L + ++
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEG 1061
Query: 161 ----GSKYEDLKEKYNKEVEERKRLEAEVKALQAKK--------------ASQTLPQATM 202
+K L+ KE+EE ++ ++K AKK A +T P
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121
Query: 203 NHRDIARHQASSSVFSWQQEKTPS-HLSSNSQR-TPIRRDFSASYFSGE-----QEVTPS 255
A QQE+ S S ++R + RD + G+ QE+ S
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 256 RSTLQIGKRDANSSFFDNSSSPHLLDQLKAQ----NQELRNK-------------INELE 298
+S L +R+ + D+ KAQ QE K +N
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Query: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
L +G KE+K V E +LE+ ++ L++ E N R A+ + +
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEE-RLRLLQAETASNSAR------------AAERSS 1288
Query: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE------KEFQEELSRQQRSFQTLDQ 412
AL ++++ L E+ QR +E+ R L + + E K +QE+ +++++ TL
Sbjct: 1289 ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQL 1348
Query: 413 E-----------------CIQMKA-------RLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
E C Q++A R +EL+Q+K L+AEL + Q+
Sbjct: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLR----AQR 1404
Query: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
L +QK+ E+ Q + ++ + +KK + LL + + E +L +
Sbjct: 1405 ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL-AEENRGLGERANLGRQ 1463
Query: 509 LKNIKQCLNQS-QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE--K 565
++ L+Q+ + + +E+ A ET L ++Q + L + K A ++ +
Sbjct: 1464 FLEVE--LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE 1521
Query: 566 QRDCSQDLLKKREHHIEQL----NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621
+R Q+ +K +EQL ++ + E+ SK L + + K + ++LK
Sbjct: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLK----AVQA 1577
Query: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681
E+++ +++++ LQ++++ E + +++ + + + L ++R+
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRS 1637
Query: 682 LHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
L + ++K + E ++L + ELQQ KE E C LT QV LE
Sbjct: 1638 LEQLQKENKELRAEAERLGH-ELQQAG-----LKTKEAEQTC---RHLTAQVRSLE---- 1684
Query: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA-----------SLVTNEDHQRSLLAFDQ 789
++ D+ +DL +++ D LKS++ SL + + L +
Sbjct: 1685 ---AQVAHADQQLRDL-GKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1740
Query: 790 QPAMHHSFANIIGEQGSMPSERSECRLEADQS-------PKNSAILQNRVDSL-EFSLES 841
P ++ GE S S+R ++E+ +S ++ A L++ +DSL + L+S
Sbjct: 1741 LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDS 1800
Query: 842 QKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
++ S +++ +++ I + ++ + + + SF + S S+
Sbjct: 1801 GRKTRS-ARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQ 1845
Score = 106 bits (265), Expect = 3e-22
Identities = 164/729 (22%), Positives = 310/729 (42%), Gaps = 114/729 (15%)
Query: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATE---QSLDPPIEEEHQLRNSI 2303
EI+ E K A N L+ + A+ GD I++ + + L + +E R+ +
Sbjct: 178 EIRFLELQKVASSSSGNNF--LSGSPASPMGD--ILQTPQFQMRRLKKQLADERSNRDEL 233
Query: 2304 EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK 2363
E LE E ++L L E + +++ R++ L A N++ AA E
Sbjct: 234 E-----LELAENRKL-----LTEKDAQIAMMQQRIDRL------ALLNEKQAASPLEPK- 276
Query: 2364 GEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423
E+E L+ K E +T L +++EK + ++ + E +L F + LQ
Sbjct: 277 -ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 2424 EKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKA 2483
+ + ++ E+ S A + + +L + ++A D++ + K + L ++ LE +
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 2484 QLLQGLDEAKN---------------------NYIVLQSSVNGLIQEVEDGKQKLE---- 2518
QL + K N LQ+ V L E E G+Q+ +
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEML--ETERGQQEAKLLAE 453
Query: 2519 --KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN------------LELRNLTVE 2564
+EE +L + I D + +S LSQ + E + + + EL L
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 2565 LEQKIQVL-------QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
++Q+ Q L + K A L TL+ + + + L +++E + E+ K A+
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS-SSLKQKEQQLKEVAE 572
Query: 2618 ETELQREMHEMAQKTAELQEELS-GEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKK 2676
+ E R+ H TA + E S E++ +L+ L +E + + L++ +E +
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 2677 SLDCMHKDQVEKEGKVREEIAEYQLRLHEA-EKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
S ++ ++ ++ E Q + A +++H+A + E+++++ ++K T K
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA--QVAELELQLRSEQQKATEK 690
Query: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL----KYVNQLK------ 2785
E E D L+ + L SLK T LEE K+ D L + +++LK
Sbjct: 691 ERVAQ----EKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL 746
Query: 2786 --------KENERAQGKMKLLIKSCKQLEE----EKEILQKELSQLQAAQEKQKTGTVMD 2833
KE E + K L +QL E E E+L++EL++ AAQ +
Sbjct: 747 VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH------TAE 800
Query: 2834 TKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLIS-HEKLEKAKEMLE---TQVAHLC 2889
++ ++L E+ +E E+ +E +Y + L++ E+ EKA++ L+ +VA +
Sbjct: 801 SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
Query: 2890 SQQSKQDSR 2898
S Q SR
Sbjct: 861 SHSELQISR 869
Score = 85.5 bits (210), Expect = 7e-16
Identities = 136/722 (18%), Positives = 293/722 (40%), Gaps = 116/722 (16%)
Query: 11 GLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQ 70
GL +++++EL + +LK++ +++ + S A + + E + L+ E
Sbjct: 1071 GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL------------ 118
+L + C+ ++ + L+ + + ++ L + + Q+E+ QEL
Sbjct: 1131 KLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR 1190
Query: 119 ----------------KRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGS 162
K+++ R +Q A+ + ++ I + +
Sbjct: 1191 ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE----G 1246
Query: 163 KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT---------LPQATMNHRDIARHQAS 213
+ ++LK E E+ ++LE ++ LQA+ AS + L + + R+ A Q
Sbjct: 1247 ESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRV 1306
Query: 214 SSVFSWQQEKTPSHLSSNSQRT-PIRRDFSA---SYFSGEQEVTPSRSTLQIGKRDANSS 269
+S E L+S ++R + ++ A +F EQ + STLQ+ +
Sbjct: 1307 AS------ENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL----STLQLEHTSTQAL 1356
Query: 270 FFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329
+ + HL QL+A+ + H +E++ L+ +L +A+ EL
Sbjct: 1357 VSELLPAKHLCQQLQAEQAAAEKR----------HREELEQSKQAAGGLRAELLRAQREL 1406
Query: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKK----LTEDLSCQRQNAESARCSL 385
E + K ++ RT Q Y LKK L E+ + A R L
Sbjct: 1407 GELIPLRQKVAEQ-ERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1465
Query: 386 EQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV 445
E ++ + +++ +EL+ + +T RL + ++A++ L+ K
Sbjct: 1466 EVELDQAREKYVQELAAVRADAET----------RLAEVQREAQSTARELEVMTAKYEGA 1515
Query: 446 KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL 505
K ++ + F+++ + + ++ + E + +EE+ K+ L S K +
Sbjct: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK--LADSDQASKVQ----- 1568
Query: 506 EAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEK 565
+ +LK ++ +SQ A+ ++A+ L +LQ +++Q+E + KL++ A
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQ-------LNELQAQLSQKEQAAEHYKLQMEKAKTH- 1620
Query: 566 QRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSE 625
D K++ +++ L + +KE+K L + E E L E E
Sbjct: 1621 -----YDAKKQQNQELQEQLRSLEQLQKENKEL-------RAEAERLGHELQQAGLKTKE 1668
Query: 626 NEKLLTQMESEKENLQSKINHLETCLK--------TQQIKSHEYNERVR-TLEMDRENLS 676
E+ + ++ +L++++ H + L+ T +KS E + + L +D +LS
Sbjct: 1669 AEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLS 1728
Query: 677 VE 678
E
Sbjct: 1729 CE 1730
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 179 bits (455), Expect = 3e-44
Identities = 396/1835 (21%), Positives = 742/1835 (40%), Gaps = 265/1835 (14%)
Query: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934
+ F+A+ I L+ H+ E+ EK L +++ E E Q L+
Sbjct: 26 EKFLADQQSEIDGLK---GRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLEL 82
Query: 935 HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
L + LK L ++ L + + +I S R EEL E L N L+QE L
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
Query: 995 QKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
+ + + E + EL Q KL LQ D+S KY+ + + K E
Sbjct: 143 EDVKRLNEKLKESNTTKGEL-----QLKLDELQA--------SDVSVKYREKRLEQEK-E 188
Query: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114
L ++ T L K + ++L ++ E L E + + E+ +++ +
Sbjct: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE----EVSRLEEQMNGLK 244
Query: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174
T N++ K L ++ KE+Q M+++ ++ L + +L + K+ + +S +
Sbjct: 245 TSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 1175 RNSVKERE---SERNQCNFKPQMDLEVKEISLDSYNAQLVQ----LEAMLRNKELKLQES 1227
+V+E E + N Q L E S D ++++ LE L N L +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 1228 EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA 1287
+++ L E + + ++ G+K E+ Y+ +L + +N
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVK----PGMKLTEL--YNAYVETQDQLLLEKLENK 417
Query: 1288 HLQCSLQTTMNKLNELEKICEILQAEKYE----LVTELNDSRSECITATRKMAEEVGKLL 1343
+ L + ++ I + Q E+YE V L+ + + +++ E+ K
Sbjct: 418 RINKYLDEIVKEVEAKAPILK-RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
Query: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMH 1403
+ +L D+ + + V+D+ ++Q V L L+E+ + + D+EV
Sbjct: 477 KQSSVLERDNRRMEIQ-VKDL---------SQQIRVLLMELEEARG--NHVIRDEEVSS- 523
Query: 1404 FAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL-STNLRNFQ---GD 1459
+ S +++ QH + ELQ L L T R Q
Sbjct: 524 --------ADISSSSEVI-SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
Query: 1460 LVKEMQLGLEEGL--VPSLSSSCVPDSSSLSSL-GDSSFYRALLEQTGDMSLLSNLEGAV 1516
+ E+QL LE L + L S + S+ YR LL QT + A+
Sbjct: 575 KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV--------AI 626
Query: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576
+ S+D+V +S + T +T S PA V +ES E +E++ +
Sbjct: 627 PLHASSLDDVSLASTPKRPST-SQTVSTPAP-VPVIES------------TEAIEAKAAL 672
Query: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636
K++QE+ + E+ E + ++ + L + ++ L S ++ ++L K+ E L
Sbjct: 673 --KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
Query: 1637 ELEVARLQLQGLDLSSRSL----------LGIDTEDAIQGRNES---CDISKEHTSETTE 1683
+E R ++ L ++ L + T+D ++G NE ++ E+ + E
Sbjct: 731 NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLKKEKE 789
Query: 1684 RTPKHDVHQICDKDA----QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
+V +++ Q+ NL + + + E +Q + E +
Sbjct: 790 MLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE-- 847
Query: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVES 1799
IS L N + L D+ L + + + NL L E
Sbjct: 848 ------ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL--------NTKEL 893
Query: 1800 LLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
L N KE+ + K HL +++ ++ K K++ DL +L +L +
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
R++TS S++E + ++ + +++ K +E ++E L K S E +
Sbjct: 954 RLKTS---TSNVEQY--QAMVTSLEESLNKEKQVTEEVRKNIEVRL------KESAEFQT 1002
Query: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTAL 1977
LE L V+ EK L+ D K++ I +E++LS + + ++ E+ + + + +TAL
Sbjct: 1003 -QLEKKLMEVEKEKQELQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 1978 ---DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034
Q +E+ + Q++ + + A+V E LQ VS++ + HL+
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV----EALQAAKEQVSKMASVRQHLE 1114
Query: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKA 2092
E Q E SQ L K E + L E V E L Q RL EKL+
Sbjct: 1115 ETTQKAE--SQLLE-CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
Query: 2093 LEAALVEKGEFALRLS---STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149
+G + LS +QE++ ++ R I R + A+ + ++ E L+ R+R
Sbjct: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR--REKEIAETRFEVAQVESLRYRQR-- 1227
Query: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVT 2207
VE LERELQ +++ L+AE K +V T KT Q EE+ + + + + T
Sbjct: 1228 ------VELLERELQELQDS-----LNAEREKVQV-TAKTMAQHEELMKKTETMNVVMET 1275
Query: 2208 ---LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264
LR EKE L + +Q+ Q ++ +L+ + ++A ++ E+S MLQ +
Sbjct: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPL-------QEANAELSEKS----GMLQAE 1324
Query: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
K L E V + + Q DP EE +L L
Sbjct: 1325 KKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKL------------------------L 1358
Query: 2325 KESEHHADLLKGRVENLER-ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383
E E H ++ E + R + EIAR+N N++ +++LK + L +
Sbjct: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSN-----ASLTNNQNLIQSLK-------EDLNKV 1406
Query: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 2443
+ TI+ + + ++Q++ + I++++ I ++ +E + ++ ++ E S+ +
Sbjct: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
Query: 2444 QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503
Q Q + E + L + K ++L SQVE L+ L + EA+N LQ
Sbjct: 1467 QEQHVSVQE-MQELKETLNQAETKSKSLESQVENLQ---KTLSEKETEARN----LQEQT 1518
Query: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV--------SKLSQVEG-EHQLWKEQ 2554
L E+ +Q L+ + + +L+ QI ++E+ SK++ + G + QL KE
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
Query: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614
EL+Q+ L + L + L+S Y+ + LE ++ +
Sbjct: 1579 E--------ELKQRNGALDQQKDELDVRITALKSQYEGRISRLE----------RELREH 1620
Query: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
+ E + E E + K E Q +++ + +GE
Sbjct: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 166 bits (420), Expect = 3e-40
Identities = 326/1726 (18%), Positives = 706/1726 (40%), Gaps = 309/1726 (17%)
Query: 1556 CEVYRQSLEKLEEKMESQGIMKNKEIQ-------ELEQLLSSERQELDCLRKQYLSENEQ 1608
C+ R LEKL ++++ KNKE++ ++ + ++EL+ ++ + NE+
Sbjct: 75 CQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER 133
Query: 1609 WQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRN 1668
Q+L +T +++ +L + K++ EL++ +LQ D+S + ++ +
Sbjct: 134 LSQELEYLTEDVK-RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192
Query: 1669 ESCDISKEHTSETTE-----RTPKHDVHQI-CDKDAQQDLNLDIEKITETGAVKPTGECS 1722
++ ++ E ++T E R +++ ++ C+ + +++ +E+ + +K + E
Sbjct: 193 QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE--QMNGLKTSNEHL 250
Query: 1723 GEQSPDT--------NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ-----EDI 1769
+ D + E+K +LS +A + N+ E++
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL 310
Query: 1770 HNLQLRVKETSNENL----RLLHVIEDRDRKVESLLNEMKELDSKL-HLQEVQLMTKIEA 1824
H L +KE N LL V + +D+ + +L ++ L+ +L + ++ TK +
Sbjct: 311 HKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 1825 CIELEK----------IVGELKKENSDLSEKLE-YFSCDHQELLQRVETSEGLNSDLEMH 1873
I E+ V ++ K L+E Y Q LL+++E N + +
Sbjct: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLE-----NKRINKY 422
Query: 1874 ADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL 1933
D+ +E + A + +E + + ++ + + E L+ D + +
Sbjct: 423 LDEIVKEV--EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 1934 CLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELES 1993
LE+DN + + L +++ V+ E + RG ++ ++ D +S + +Q L S
Sbjct: 481 VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD-ISSSSEVISQHLVS 539
Query: 1994 H--------QSECLHCIQVAEAEVKEKTELLQTLSSDVSEL-LKDKTHLQEKLQSLEKDS 2044
+ Q++ L E +E+ E +T SS ++EL LK ++ L E L+ L K
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETREREEQ-ETTSSKITELQLKLESALTE-LEQLRKSR 597
Query: 2045 QALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLN-------------VSK 2091
Q + +L + I + +L+ ++ + L S + ++ VS
Sbjct: 598 QH----QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVST 653
Query: 2092 ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH-------------- 2137
++E E A+ + +++ ++ +K + E + +QL
Sbjct: 654 PAPVPVIESTE-AIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712
Query: 2138 -IAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMAR 2196
I+ +L + + L+D VE RE+ E + + + + + T+ +
Sbjct: 713 KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
Query: 2197 SLKVFELDLVTLRSEKENL----TKQIQEKQGQLSEL---DKLLSSFKSLLEEKEQAEIQ 2249
L V E+ L+ EKE L + Q+++ L+E + LL++ +++ E++E +
Sbjct: 773 KLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETE 832
Query: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE----K 2305
K+ + +E L++++ L ++ L+ +E+ H L +++
Sbjct: 833 TKQRLSSQIEKLEHEISHL-----------------KKKLENEVEQRHTLTRNLDVQLLD 875
Query: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
+ +L+ + L + LK ++ LK + N+E +++A + + ++K +
Sbjct: 876 TKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNME--VQVASQSSQRTGKGQPSNKED 933
Query: 2366 VETLKAKI-----------EGMTQSLRGLELDVVTIRSEKENLTNELQKEQE-------R 2407
V+ L +++ E + S +E + S +E+L E Q +E R
Sbjct: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
Query: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND-QEACKA 2466
+ E + E L E E+EK ++++ A+E ++ QL EL + ++++ N+ QEA +
Sbjct: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 2467 KEQNLSSQ-------------------------------VECLELEKAQLL------QGL 2489
LS++ VE L+ K Q+ Q L
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 2490 DEA---------------KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI--- 2531
+E + +L+ V+ + ED +++ ++I +L +++
Sbjct: 1114 EETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVAS 1173
Query: 2532 -----------------QDQEQLVSKLSQVEGEHQLWKEQNLELRNL-TVELEQKIQVLQ 2573
+ QEQ++ L + E ++ E E+ + ++ Q++++L+
Sbjct: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEI-AETRFEVAQVESLRYRQRVELLE 1232
Query: 2574 SKNASLQDTL----EVLQSSYKNLENELELTKM-DKMSFVEKVNKMTAKETE-LQREMHE 2627
+ LQD+L E +Q + K + EL K + M+ V + NKM +E E L++++ +
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Query: 2628 MAQKTAELQ----------EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE---- 2673
M K +L+ ELS + L E +LL E++K K + + L + +
Sbjct: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 2674 ------LKKSLDCMHKDQVEKE-GKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE---- 2722
+K + Q+ +E G+++ EIA L + Q+L D NK
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 2723 ---------VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL----------NNSLKAT 2763
++IQ + +T ++ K + + LK+ ++++ + +
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
Query: 2764 TQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQ 2823
Q ++ELK+T +NQ + +++ + +++ L K+ + E E LQ++ QLQ+
Sbjct: 1473 VQEMQELKET-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSEL 1525
Query: 2824 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL----DKYCSLLISHEKLEKAKE 2879
+ + + + TT+ ++L++ + EK ++ + + K L ++L K E
Sbjct: 1526 SR------LRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENE 1579
Query: 2880 MLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIW 2939
L+ + L Q+ + D R + L S E R+S + + ++R
Sbjct: 1580 ELKQRNGALDQQKDELDVRITAL-----------KSQYEGRISRLERELREHQERHLEQR 1628
Query: 2940 ENGRGPTPATPESFSKKSKKAVMS----GIHPAEDTEGTEFEPEGLPEVVKKGFADIPTG 2995
+ + P+ PE + + K + GI D +P + K A G
Sbjct: 1629 DEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAG 1688
Query: 2996 -KTSP--YILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKP 3038
K++P I T AT T+P + + + +S P
Sbjct: 1689 NKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGP 1734
Score = 165 bits (417), Expect = 7e-40
Identities = 269/1355 (19%), Positives = 564/1355 (41%), Gaps = 257/1355 (18%)
Query: 1770 HNLQLRVKETSN-ENLRLLHVIEDRDRKVESLLNEMKEL----DSKLHLQEVQLMTKIEA 1824
H+ + V ET ++LRL +E + ++++L + KEL D + +Q TK E
Sbjct: 63 HSQERLVNETRECQSLRL--ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEE- 119
Query: 1825 CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGD 1884
+E EK +L + N LS++LEY + D + L ++++ S +L++ D+ D
Sbjct: 120 -LEAEK--RDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD--- 173
Query: 1885 NVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEK----LCLEKDNE 1940
V+ ++E+ L+ E EL + S+ + E +L + EK L L+ + E
Sbjct: 174 ----VSVKYREKRLEQEKEL--LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLE 227
Query: 1941 NKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALDQ-----------------LSE 1982
NK++ + LEE+++ + + L+ + D ++K A +Q LS
Sbjct: 228 NKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN 287
Query: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ----EKLQ 2038
K + E+ +E ++ +KE E + + + E+ + K ++ EK+
Sbjct: 288 LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIG 347
Query: 2039 SLEKD----SQALSLTKCE----LENQIAQLNKEKELL-------VKESESLQARLSESD 2083
LEK+ + LS TK + E ++A ++ + +K +E A + D
Sbjct: 348 RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 2084 Y------EKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH 2137
E ++K L+ + E A L +EE + ++ + L V++E K+
Sbjct: 408 QLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQR 467
Query: 2138 IAEKLKER-------ERENDSLKDKVENLEREL-----QMSEENQELVILDAENSKAEV- 2184
+ E + ER+N ++ +V++L +++ ++ E VI D E S A++
Sbjct: 468 LQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADIS 527
Query: 2185 ----------------ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ----G 2224
E L+ Q + + +L+ EL R E+E + +I E Q
Sbjct: 528 SSSEVISQHLVSYRNIEELQQQNQRLLVALR--ELGETREREEQETTSSKITELQLKLES 585
Query: 2225 QLSELDKLLSSFK-------SLLEEKEQAEIQIKEESKTAVEMLQNQLKELN-------- 2269
L+EL++L S + S++ +++ I + + + A+ + + L +++
Sbjct: 586 ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
Query: 2270 ------------------EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
EA+ A +++ + E E E +EKL+ ++
Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
Query: 2312 ADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA 2371
+ + QL + ++L+ VE RE+ + + + + T+
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 2372 KIEGMTQSLRGLELDVVTIRSEKENLT-NELQKEQERISEL------EIINSSFENILQE 2424
+ G + L E+ ++ EKE L +E++ Q+R S L ++ ++ + I
Sbjct: 766 DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
Query: 2425 KEQEKVQMKEKSSTAMEMLQTQL----KELNERVAALHN-----DQEACKAKEQ------ 2469
E+ + + K++ S+ +E L+ ++ K+L V H D + K Q
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 2470 ---NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ-----EVEDGKQKLEKKD 2521
N ++ + E A L Q L + S G Q +V+D +L + +
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 2522 EEISRLKNQI--------QDQEQLVSKLSQVEGEHQLWKE--QNLELR-----NLTVELE 2566
E+++ LK ++ Q Q + S + E Q+ +E +N+E+R +LE
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE 1005
Query: 2567 QKIQVLQSKNASLQD----TLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622
+K+ ++ + LQD +E ++ L+ L + + +++ + + E + +
Sbjct: 1006 KKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQAR 1065
Query: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS----- 2677
R+ E A+ E Q + E A ++ E ++++K+Q+ ++ L+++
Sbjct: 1066 RDCQEQAKIAVEAQNKYERELMLHAADV----EALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 2678 ---LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE---- 2730
L+C + E+E +++E+++ R + EK+++ L K + + + +E
Sbjct: 1122 SQLLECKASWE-ERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
Query: 2731 --KLTSKEECLSSQKL------------------------------EIDLLKSSKEELNN 2758
++ EE S +++ ++LL+ +EL +
Sbjct: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
Query: 2759 SLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2818
SL A + ++ KT + +L K+ E M +++++ K L EEKE L+++L Q
Sbjct: 1241 SLNAEREKVQVTAKTMAQH----EELMKKTET----MNVVMETNKMLREEKERLEQDLQQ 1292
Query: 2819 LQAAQEK--------QKTGTVMDTKVDELTTEIKELKETLEE--------KTKEADEYLD 2862
+QA K Q+ + K L E K L+E ++ +++ D +
Sbjct: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 2863 KYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
+Y LL E K + L ++ L ++ ++ ++
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Score = 164 bits (416), Expect = 1e-39
Identities = 344/1695 (20%), Positives = 691/1695 (40%), Gaps = 208/1695 (12%)
Query: 280 LDQLKAQNQELR----NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVE---LIEK 332
+D LK ++++ + + E+E RL ++ + + + Q L+L+LEK + L EK
Sbjct: 36 IDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK 95
Query: 333 EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
K L +D + +Q+ + + A ++ L + E LS + + L +K+KE
Sbjct: 96 NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155
Query: 393 EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL----DKLTSVKQ- 447
+ EL + Q D + RL QE + + + L EL D+L ++ +
Sbjct: 156 NTT-KGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 448 ------QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501
+L+ NLE K+++ R E+ + L++ +E++ + LK EQ+A
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK---LKEAKEQQASM 271
Query: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561
EL + N ++ A++ +AK+ + +L + + +E + ++ +
Sbjct: 272 EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL--KEAGEANKAIQDHLL 329
Query: 562 DLEKQRD-CSQDLLKK---REHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEK- 616
++E+ +D +++L+K E +E ND LS T+++ A+LS EL K
Sbjct: 330 EVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG-AILSEEELAAMSPTAAAVAKI 388
Query: 617 --------TLFSCW-KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
L++ + +++++ LL ++E+++ N +L+ +K E +
Sbjct: 389 VKPGMKLTELYNAYVETQDQLLLEKLENKRIN-----KYLDEIVK-------EVEAKAPI 436
Query: 668 LEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ 727
L+ RE E + S SV++E A E+Q+ E +D K K+ + +
Sbjct: 437 LKRQRE----EYERAQKAVASLSVKLEQ---AMKEIQRLQEDTD-KANKQSSVLERDNRR 488
Query: 728 LTGQVEDLEHKLQLLSNE---------IMDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
+ QV+DL ++++L E I D++ D+ + E + L S +
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
Query: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838
+QR L+A E E R +Q +S I + ++ LE +
Sbjct: 549 QNQRLLVAL---------------------RELGETREREEQETTSSKITELQL-KLESA 586
Query: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
L +Q+ Q Q ++ +++++ M++ +++T+ L S+ +V
Sbjct: 587 LTELEQLRKSRQHQM--------QLVDSIVRQRDMYRILLSQTTGVAIPLH--ASSLDDV 636
Query: 899 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
+L++ + Q ++ E E ++ + +LK+LQ + E EK E
Sbjct: 637 ---SLASTPKRPSTSQTVSTPAPVPVIESTEAIEA----KAALKQLQEIFENYKKEKAEN 689
Query: 959 SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
I ++E+L ++ L+ N ++ + ++ E + ++ + I+ L ++
Sbjct: 690 EKI---QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER- 745
Query: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAF 1078
Q+ Q+ E+ N ++Q + A EK + E EN K E E LK +
Sbjct: 746 NQKLTATTQKQEQIINT---MTQDLRGANEKLAVAEV-------RAENLKKEKEMLKLSE 795
Query: 1079 AKEHQEFLTKLAFAEERNQNLML-ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE 1137
+ Q+ + AE+R QNL+L L+T+Q L T+ + S+ L+ EI LK+
Sbjct: 796 VRLSQQ--RESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
Query: 1138 EQNKMQKEVNDLLQENEQL-MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM-D 1195
K++ EV L ++++ TK + + + + +++ K + +
Sbjct: 854 ---KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSN 910
Query: 1196 LEVKEISLDSYNAQLVQLEAMLRNKE------LKLQESEKEKECLQHELQTIRGDLETSN 1249
+EV+ S S + NKE +L+++E++ L+ L+T TSN
Sbjct: 911 MEVQVASQSSQRTG----KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT-----STSN 961
Query: 1250 LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEI 1309
++ Q+ ++ L++ ++ + ++A Q L+ KL E+EK +
Sbjct: 962 VEQYQAM-VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE---KKLMEVEKEKQE 1017
Query: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
LQ +K + + SE + EV + L + + E
Sbjct: 1018 LQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVE 1077
Query: 1370 GEQPNEQH-PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428
+ E+ + A ++ + + V+ H E +K S E K ++ +M
Sbjct: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
Query: 1429 -SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSL 1487
++S+ + L+ +N +L + +V ++ G++ L SLS L
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
Query: 1488 SSLG------------------DSSFYR---ALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
L +S YR LLE+ L L+ +++A + V
Sbjct: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE-----LQELQDSLNAEREKVQVT 1252
Query: 1527 FCSSLQEENLTRK-ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGI------MKNK 1579
+ Q E L +K ET + + + L E Q L++++ K+ + N
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 1580 EIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEK----KQTEQLS 1635
E+ E +L +E++ L+ K++ + N+ + E KL +EK K+ +QL+
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT 1372
Query: 1636 LELEVARLQLQGLDLS---SRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPK-HDVH 1691
E+ + ++ + S +++L+ ED + R E I K+ ++ + K +
Sbjct: 1373 EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTIT 1432
Query: 1692 QICD-----KDAQQDLNLDIEKITETGAVKPTGECSGE-QSPDTNYEPPGEDKTQGSSEC 1745
Q+ K ++L +K+ ET A + SG+ Q + + E K +
Sbjct: 1433 QVKKIGRRYKTQYEELKAQQDKVMETSA-----QSSGDHQEQHVSVQEMQELKETLNQAE 1487
Query: 1746 ISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
S + + + NLQ + + +E RL ++DR + E L ++
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQIT 1547
Query: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEG 1865
E + K V +KI L + +L KEN +L ++ EL R+
Sbjct: 1548 EKEEKTRKAIVAAKSKI---AHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI---TA 1601
Query: 1866 LNSDLEMHADKSSRE 1880
L S E + RE
Sbjct: 1602 LKSQYEGRISRLERE 1616
Score = 160 bits (406), Expect = 1e-38
Identities = 325/1585 (20%), Positives = 650/1585 (41%), Gaps = 257/1585 (16%)
Query: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL------ 72
+I L+G+ +K K E +Q+ F++ E L ++++ NE E +L+ E ++L
Sbjct: 35 EIDGLKGRHEKFKVESEQQYFEI---EKRLSHSQERLVNETRECQSLRLELEKLNNQLKA 91
Query: 73 -------MEICES--------LEKTKQKISHELQ--VKESQVNFQEGQ-LNSGKKQIEKL 114
+EI + +TK+++ E + ++ ++ QE + L K++ +
Sbjct: 92 LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEK 151
Query: 115 EQELKRCKSELERSQQAAQSADVSLNP------------------CNTPQKIFTTPLTPS 156
+E K EL+ Q++DVS+ NT K T L
Sbjct: 152 LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLAL 211
Query: 157 QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ-AKKASQTLPQATMNHRDIARHQASSS 215
G++ +LK + EE RLE ++ L+ + + Q + + A+ Q +S
Sbjct: 212 GREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQAS- 270
Query: 216 VFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSS 275
+EK + L+++ + + + + + + E+T R+ ++ K + + +
Sbjct: 271 ----MEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT--RAVEELHKLLKEAGEANKAI 324
Query: 276 SPHLLDQLKAQNQ---ELRNKINELELRLQG-----HEKEMKGQVNKFQELQ-------- 319
HLL+ ++++Q E+ KI LE L+ + KG + +EL
Sbjct: 325 QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAA 384
Query: 320 -LQLEKAKVELIEKEKVLNKCRDELV-------RTTAQYDQASTKYTALEQKLKKLTEDL 371
++ K ++L E + +D+L+ R D+ + A LK+ E+
Sbjct: 385 VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY 444
Query: 372 SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR----------L 421
++ S LEQ +KE ++ QE+ + + L+++ +M+ + L
Sbjct: 445 ERAQKAVASLSVKLEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVL 503
Query: 422 TQELQQAKNMHNVLQAE----------------------LDKLTSVKQQLENNLEEFKQK 459
EL++A+ H + E +++L Q+L L E +
Sbjct: 504 LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGET 563
Query: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519
R EQ +S+I E +L+ +E E L+ + + + V + + + L+Q+
Sbjct: 564 REREEQETTSSKITELQLK--LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
Query: 520 Q--------------NFAEEMKAKNTSQ-------------------ETMLRDLQEKI-- 544
+ A K +TSQ + L+ LQE
Sbjct: 622 TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFEN 681
Query: 545 -------NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
N++ + LEKL+ V DL Q L E L D + +E +
Sbjct: 682 YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITS 741
Query: 598 LLSA-LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
L +L ++ + T+ + NEKL E ENL+ + + LK ++
Sbjct: 742 LHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV-AEVRAENLKKE----KEMLKLSEV 796
Query: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-LQQKAEFSDQKHQ 715
+ + E + + + L ++ + +L+ E + + + +E L+ + +K +
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
Query: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
E+E T L Q+ D + +L +N ++ ++ E +L+ L + + +
Sbjct: 857 NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
Query: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
+ Q S QP+ +++ + + ++ + S N Q V SL
Sbjct: 917 S----QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSL 972
Query: 836 EFSLESQKQMNSDLQKQCE----ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED 891
E SL +KQ+ +++K E E + + ++E+ LM+ E+ Q + + I +++
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQ 1032
Query: 892 TSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQL 946
S + +TLS+++N+ +E LQ + + EQ ++ ++ + ++ +EL L
Sbjct: 1033 LSE----LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELML 1088
Query: 947 LS---ETLSLEKKEMSSIISLNKREIEELTQE-NGTLKEINASLNQEKMNLIQKSESFAN 1002
+ E L K+++S + S+ ++ +EE TQ+ L E AS + + L
Sbjct: 1089 HAADVEALQAAKEQVSKMASV-RQHLEETTQKAESQLLECKASWEERERML--------- 1138
Query: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
DE K + D KQ +L+ + E LS K A+ ++ ++ LN S
Sbjct: 1139 -KDEVSKCVCRCEDLEKQNRLL--------HDQIEKLSDKVVASVKEG--VQGPLN--VS 1185
Query: 1063 LCENRKNELEQLKE--AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
L E K++ EQ+ E F + +E AE R + + ++E+++ R E+ + +
Sbjct: 1186 LSEEGKSQ-EQILEILRFIRREKE------IAETRFE--VAQVESLRYRQRVELLERE-- 1234
Query: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
L++ +L E+ K+Q + Q +E+LMK K E N+ E N +
Sbjct: 1235 -------LQELQDSLNAEREKVQVTAKTMAQ-HEELMK----KTETMNVVME--TNKMLR 1280
Query: 1181 RESERNQCNFKPQMDLEVKEISLD-----SYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
E ER + + + QM +V+++ LD NA+L + ML+ ++ L+E K +
Sbjct: 1281 EEKERLEQDLQ-QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE--KYISGPHELSTSQNDNAHLQCSL 1293
L + + D +T + + S++ K + EE + + + S +N +L SL
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 1294 QTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
+ +NK+ E E I + L A+ ++ + + IT +K+ E+K D
Sbjct: 1400 KEDLNKVRTEKETIQKDLDAKIIDI-----QEKVKTITQVKKIGRRYKTQYEELKAQQDK 1454
Query: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE-SNSYEHLTLSDKEVQMHFAELQEKF 1411
V + G+ EQH VS+ + E + K ++ LQ+
Sbjct: 1455 --------VMETSAQSSGDH-QEQH-VSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
Query: 1412 LSLQSEHKILHDQHCQMSSKMSELQ 1436
++E + L +Q Q+ S++S L+
Sbjct: 1505 SEKETEARNLQEQTVQLQSELSRLR 1529
Score = 152 bits (385), Expect = 4e-36
Identities = 224/1104 (20%), Positives = 472/1104 (42%), Gaps = 164/1104 (14%)
Query: 1895 ERFL-DVENELSRI--RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
E+FL D ++E+ + R EK +E E Y E +EK + Q E
Sbjct: 26 EKFLADQQSEIDGLKGRHEKFKVESEQQYFE------------IEKRLSHSQ-------E 66
Query: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE 2011
L T E LR EL+ ++ + AL + +++++ + QS+ + EAE ++
Sbjct: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
Query: 2012 KTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKE 2071
+ LS ++ L +D L EKL+ L L EL+ + ++ L +E
Sbjct: 127 LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
Query: 2072 SESLQARLSESDYEKLNVSKALEAALVEKG----EFALRLSSTQEEVHQLRRGIEKLRVR 2127
E L ++ + + E + L A EKG E L + +EEV +L + L+
Sbjct: 187 KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTS 246
Query: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
E +K + KLKE + + S+++K N EL + L A++S+A+ L
Sbjct: 247 NEHLQKHVEDLLTKLKEAKEQQASMEEKFHN---ELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 2188 KTQIEEMARSL-------KVFELDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSF 2236
+EE+ + L K + L+ + K+ + K++ EK G +L + LLS+
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 2237 K---SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS----- 2288
K ++L E+E A + + + +L EL A DQ +++ E
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVE-TQDQLLLEKLENKRINKY 422
Query: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348
LD ++E +++ R E +K + +L+++ ++ L+ + +
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA-------MKEIQRLQEDTD-- 473
Query: 2349 RTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS-----EKENLTNELQK 2403
+ N++ + LE +N + E++ ++ ++Q +R L +++ R ++E + ++
Sbjct: 474 KANKQSSVLERDNRRMEIQ-----VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
Query: 2404 EQERISELEIINSSFENILQEKEQEKVQMKEKSST----AMEMLQTQLKELNERVAALHN 2459
E IS+ + + E + Q+ ++ V ++E T E +++ EL ++ +
Sbjct: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALT 588
Query: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
+ E + Q+ V+ + ++ L + I L +S + K+
Sbjct: 589 ELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS 648
Query: 2520 KDEEISRLKNQIQDQEQLVSK-----LSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQ 2573
+ I+ E + +K L ++ ++ K +N +++N +E L++++ L+
Sbjct: 649 QTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLR 708
Query: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
S+N + L+ Y+ L++ +E + + S E+ K+TA + ++ ++ M Q
Sbjct: 709 SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ--- 765
Query: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL--------------- 2678
+L G +LA ++ E +K K+ LK + S+ ++SL
Sbjct: 766 ----DLRGANEKLA-VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ 820
Query: 2679 ---DCMHKDQVEKE-------GKVREEIAEYQLRL-HEAEKKH------QALLLDTNKQY 2721
+ + + E + K+ EI+ + +L +E E++H LLDT +Q
Sbjct: 821 TIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
Query: 2722 EV-----------------EIQTYREKLTSKEECLSSQKLE----------------IDL 2748
+ EI T ++ L++ E ++SQ + +
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 2749 LKSSKEELNN---SLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQL 2805
L+ ++E++N+ LK +T +E+ + + +N+ K+ E + +++ +K +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 2806 EEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYC 2865
+ + L+K+L +++ +EKQ+ ++ + ++ ELK+TL E E L +
Sbjct: 1001 QTQ---LEKKLMEVE--KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAS 1055
Query: 2866 SLLISHEKL-----EKAKEMLETQ 2884
+ L + ++ E+AK +E Q
Sbjct: 1056 TALSNEQQARRDCQEQAKIAVEAQ 1079
Score = 150 bits (380), Expect = 1e-35
Identities = 284/1397 (20%), Positives = 565/1397 (40%), Gaps = 196/1397 (14%)
Query: 5 LEEWKEGLPTRALQKIQELEGQL----DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
+E+ K+ + L+KI LE +L D L K++ + AA+ V
Sbjct: 331 VEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV----- 385
Query: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
+ + +L E+ + +T+ ++ E +++ ++N L+ K++E LKR
Sbjct: 386 --AKIVKPGMKLTELYNAYVETQDQLLLE-KLENKRIN---KYLDEIVKEVEAKAPILKR 439
Query: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
+ E ER+Q+A S V L Q + +K + E+ N +R
Sbjct: 440 QREEYERAQKAVASLSVKLE-----QAMKEIQRLQEDTDKANKQSSVLERDN------RR 488
Query: 181 LEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR 238
+E +VK L Q + L +A NH I + SS+ S E HL S
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNH-VIRDEEVSSADISSSSEVISQHLVS-------- 539
Query: 239 RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
+ +E+ L + R+ + + + + + +KI EL+
Sbjct: 540 -------YRNIEELQQQNQRLLVALRELGET------------REREEQETTSSKITELQ 580
Query: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-------------NKCRDELVR 345
L+L+ E++ Q+ K ++ Q+QL + V + ++L + D +
Sbjct: 581 LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
Query: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
+T + + ST T + E S + A++A L++ + +KE E Q
Sbjct: 640 STPK--RPSTSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNE 695
Query: 406 SFQTLDQECIQMKA---RLTQELQQAKNMHNVLQAELD--------------KLTSVKQQ 448
+ L ++ +++ +++ +L A + +LQ ++ KLT+ Q+
Sbjct: 696 QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK 755
Query: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
E + Q L A + ++++ L++ E +K L E E
Sbjct: 756 QEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLL 815
Query: 509 LKNIKQCLNQSQNFAEEMKAKNTSQ----ETMLRDLQEKI-NQQENSLTLEK-LKLAVAD 562
L N++ + E K + +SQ E + L++K+ N+ E TL + L + + D
Sbjct: 816 LTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD 875
Query: 563 LEKQRDCSQDLLKKREHHIEQLNDK--LSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
++Q D +L LN K L +KE L L + + ++T
Sbjct: 876 TKRQLDTETNL---------HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRT--G 924
Query: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD---RENLSV 677
+ N++ + + S+ + ++N L+ LKT +Y V +LE + ++
Sbjct: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
Query: 678 EIRNLHNVLDSKSVEVETQ---KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
E+R V +S E +TQ KL +E ++K E D K ++ IE+M Q+ +
Sbjct: 985 EVRKNIEVRLKESAEFQTQLEKKLMEVE-KEKQELQDDK-RRAIESM-------EQQLSE 1035
Query: 735 LEHKLQLLSNEIMDK-DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
L+ L + NE+ + R L E ++ RD + ++ ++R L+ +
Sbjct: 1036 LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM-------L 1088
Query: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK-- 851
H + + S+ + R +++ + + ++++ + S E +++M D
Sbjct: 1089 HAADVEALQAAKEQVSKMASVRQHLEETTQKA---ESQLLECKASWEERERMLKDEVSKC 1145
Query: 852 --QCEELVQIKGEIEENLMKAEQMHQSFVAETSQ---RISKLQEDTSAHQNVVAETLSAL 906
+CE+L + + + + K + V E Q +S +E S Q L L
Sbjct: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ-----ILEIL 1200
Query: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
+E ++ + E Q E ++ LLE L+ELQ S EK ++++
Sbjct: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ-DSLNAEREKVQVTAKTMAQH 1259
Query: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
E+ + T+ + E N L +EK L Q + + + E I L +
Sbjct: 1260 EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE---------- 1309
Query: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL-EQLKEAFAKEHQEF 1085
A +LS+K Q + LL E + R L Q K+ +E+++
Sbjct: 1310 --------ANAELSEKSGMLQAEKK----LLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
Query: 1086 LTKLAFAEERNQNLMLELETVQQAL---RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1142
L++ +R Q L E+ ++ + + +T+NQN +S LK+++ ++ E+ +
Sbjct: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS----LKEDLNKVRTEKETI 1413
Query: 1143 QKEVNDLLQENEQLMKVM----------KTKHECQNLESEPIRNSVKERESERNQCNFKP 1192
QK+++ + + ++ +K + KT++E + + + + + + + +
Sbjct: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
Query: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNL 1250
Q E+KE +L+ + LE+ + N + L E E E LQ + ++ +L +L
Sbjct: 1474 QEMQELKE-TLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532
Query: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
QD +QE L+ + EEK + +++ AHL + EL++ L
Sbjct: 1533 QDRTTQE-EQLRQQITEKEEKTRKA---IVAAKSKIAHLAGVKDQLTKENEELKQRNGAL 1588
Query: 1311 QAEKYELVTELNDSRSE 1327
+K EL + +S+
Sbjct: 1589 DQQKDELDVRITALKSQ 1605
Score = 139 bits (350), Expect = 4e-32
Identities = 204/989 (20%), Positives = 431/989 (43%), Gaps = 99/989 (10%)
Query: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
+++++L+ Q+ L+ + + QLD + + VE + E T+L NQ+L +
Sbjct: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
Query: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
E+ ++ +L+ ++ E + + KK+ E L+ R + E + ++
Sbjct: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
Query: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYE-------DLKEKYNKEVEERKRL--EAEVKAL 188
L T Q I T ++ S+ E LK+K EVE+R L +V+ L
Sbjct: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
Query: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL---SSNSQRTPIRRDFSASY 245
K+ T +N +++ ++ A + + +Q + + S +SQRT
Sbjct: 875 DTKRQLDTETNLHLNTKELLKN-AQKEIATLKQHLSNMEVQVASQSSQRT------GKGQ 927
Query: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
S +++V S L+ + N +S ++Q +A L +N+ + +
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
Query: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
K ++ ++ + E Q QLEK +E +EKEK EL D ++EQ+L
Sbjct: 988 KNIEVRLKESAEFQTQLEKKLME-VEKEK------QEL------QDDKRRAIESMEQQLS 1034
Query: 366 KLTEDLSCQRQNAESA--RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
+L + LS + + A R S +++ + +E ++ Q + + + A +
Sbjct: 1035 ELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF-QASQIKENELRRSM- 481
LQ AK ++ K+ SV+Q LE ++ + +L + ++ + ++ ++E+ + +
Sbjct: 1095 ALQAAKE-------QVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
Query: 482 --EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
E+++K+N LL E+ + +V + ++K+ + N + + + SQE +L
Sbjct: 1148 RCEDLEKQNRLLHDQIEKLSDKV------VASVKEGVQGPLNVS--LSEEGKSQEQILEI 1199
Query: 540 LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
L + ++E + + ++A + + R + L ++ + + LN + K + +K +
Sbjct: 1200 L--RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
Query: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
EL KK E + + E E+L E + + +Q+K+ LE + Q +
Sbjct: 1258 QHEELMKKT-ETMNVVMETNKMLREEKERL----EQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 660 EYNERVRTLEMDRENLSVEI-----RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
E +E+ L+ +++ L ++ RN H V K + E Y +L + E ++
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE----EYRKLLSEKEVHTKRI 1368
Query: 715 Q---KEIENMCLKTSQLTGQVEDLEHKLQLLSNEI----MDKDRCYQDLHAEYESLRDLL 767
Q +EI + + ++ + + ++ +Q L ++ +K+ +DL A+ +++ +
Sbjct: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV 1428
Query: 768 K--SKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG---EQGSMPSERSECRLEADQSP 822
K ++ + Q L Q M S A G EQ E E + +Q+
Sbjct: 1429 KTITQVKKIGRRYKTQYEELKAQQDKVMETS-AQSSGDHQEQHVSVQEMQELKETLNQAE 1487
Query: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
S L+++V++L+ +L ++ +LQ E+ VQ++ E+ ++ Q T+
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQ---EQTVQLQSEL-------SRLRQDLQDRTT 1537
Query: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Q +L++ + + + + A ++K L + D++ E +ELK+ N L+
Sbjct: 1538 QE-EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN---EELKQRNGALDQQKD 1593
Query: 943 ELQLLSETLSLEKKEMSSIISLNKREIEE 971
EL + L K + IS +RE+ E
Sbjct: 1594 ELDVRITAL---KSQYEGRISRLERELRE 1619
Score = 106 bits (265), Expect = 3e-22
Identities = 239/1168 (20%), Positives = 470/1168 (40%), Gaps = 192/1168 (16%)
Query: 5 LEEWKEGLPTRALQKIQELEGQLDKLKK----EKQQRQFQLDSLEAALQKQKQKVENEKT 60
LE + R +I++LE ++ LKK E +QR +L+ L K++++ E
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE-- 883
Query: 61 EGTNLKRENQRLMEICE-SLEKTKQKISH-ELQV--------------KESQVNFQEGQL 104
TNL + L++ + + KQ +S+ E+QV + V+ QL
Sbjct: 884 --TNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
Query: 105 NSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP----CNTPQKIFTTPLTPSQYYS 160
++Q+ L++ LK S +E+ Q S + SLN +K L S +
Sbjct: 942 RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 161 GSKYEDLK--EKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFS 218
+ L EK +E+++ KR E Q + +TL + N A +AS+++ +
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL-SSVQNEVQEALQRASTALSN 1060
Query: 219 WQQEK----TPSHLSSNSQRTPIRR------DFSASYFSGEQ--EVTPSRSTLQIGKRDA 266
QQ + + ++ +Q R D A + EQ ++ R L+ + A
Sbjct: 1061 EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKA 1120
Query: 267 NSSFFDNSSS----PHLL-----------DQLKAQNQELRNKINELELRLQGHEKE-MKG 310
S + +S +L + L+ QN+ L ++I +L ++ KE ++G
Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
Query: 311 QVN-------KFQELQLQLEKAKVELIEKEKVLNKCRDELVRT-TAQYDQASTKYTALEQ 362
+N K QE L++ + I +EK + + R E+ + + +Y Q + LE+
Sbjct: 1181 PLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQVESLRYRQ---RVELLER 1233
Query: 363 KLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT 422
+L++L + L NAE + + K + +E ++ +T ++ + K RL
Sbjct: 1234 ELQELQDSL-----NAEREKVQVTAKTMAQHEELMKKTETMNVVMET-NKMLREEKERLE 1287
Query: 423 QELQQAKNMHNVLQAELDKLTSVKQQL---------ENNLEEFKQKLCRAEQAFQASQIK 473
Q+LQQ + L+ ++ L +L E L E K +A SQ K
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK 1347
Query: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK---- 529
+ + ++ E + +Q E+ L+AE+ L +QN + +K
Sbjct: 1348 DPD-TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
Query: 530 NTSQETMLRDLQEK-INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKL 588
T +ET+ +DL K I+ QE T+ ++K + ++ + LK ++ DK+
Sbjct: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVK----KIGRRYKTQYEELKAQQ-------DKV 1455
Query: 589 SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE 648
+T +S + +E +ELKE L Q E++ ++L+S++ +L+
Sbjct: 1456 METSAQSSGDHQEQHVSVQEMQELKE--------------TLNQAETKSKSLESQVENLQ 1501
Query: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE 708
L ++ ++ R L+ L E+ L L ++ + E + E ++K
Sbjct: 1502 KTLSEKETEA-------RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 709 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL----- 763
+ + +I ++ QLT + E+L+ + L + + D L ++YE
Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
Query: 764 RDLLKSKDASLVTNEDHQR-SLLAFDQQPAMHHSFANIIGEQG----------------- 805
R+L + ++ L ++ Q S +QQ + GE+G
Sbjct: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPV 1674
Query: 806 -SMPSERSECRLEADQSPKNSAI--------LQNRVDSLEFSLESQKQMNSDLQKQCEEL 856
S PS+ + + ++S ++I + N + ++ Q+ S Q E
Sbjct: 1675 VSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGP 1734
Query: 857 VQ------------------IKGEIEENLMKAEQMHQ--SFVAETSQRISKLQEDTSAHQ 896
V+ ++ I + ++ +Q Q +FV T Q +++
Sbjct: 1735 VEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELS 1794
Query: 897 NVVAETL--SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL--QLLSETLS 952
+ + E + S +E + T + + K++ EDS E Q+ +T+
Sbjct: 1795 SNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLP--KRTREEEEDSTIEASDQVSDDTVE 1852
Query: 953 LE-KKEMSSIISLNKREIEELTQENGTLKEINASL-NQEKMNLIQKSESFANYIDEREKS 1010
+ K++ S+ + EE+ E T E+ + NQ+ + I + + +Y +
Sbjct: 1853 MPLPKKLKSVTPVGTE--EEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMED-- 1908
Query: 1011 ISELSDQYKQEKLILLQRCEETGNAYED 1038
SE + Q Q L LQ ++T + +D
Sbjct: 1909 -SEETSQSLQIDLGPLQSDQQTTTSSQD 1935
Score = 67.8 bits (164), Expect = 2e-10
Identities = 65/258 (25%), Positives = 117/258 (45%), Gaps = 53/258 (20%)
Query: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY-EVEIQTYREKLTSKEECLSSQKLEID 2747
+ K+ + +A+ Q + + +H+ +++ +QY E+E ++L+ +E L ++ E
Sbjct: 22 QNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE-----KRLSHSQERLVNETRECQ 76
Query: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
L+ E+LNN LKA T+ +EL+ + N+ +Q + E + + + LI++ ++L +
Sbjct: 77 SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
Query: 2808 EKEIL---------------------QKELSQLQAA------------QEKQKT------ 2828
E E L Q +L +LQA+ QEK+
Sbjct: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTW 196
Query: 2829 -GTVMDTKVDELTT-------EIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
T + TK DEL EI ELK LE K +E ++ L S+E L+K E
Sbjct: 197 LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVED 256
Query: 2881 LETQVAHLCSQQSKQDSR 2898
L T++ QQ+ + +
Sbjct: 257 LLTKLKEAKEQQASMEEK 274
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 179 bits (454), Expect = 4e-44
Identities = 267/1149 (23%), Positives = 508/1149 (44%), Gaps = 160/1149 (13%)
Query: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886
ELE+ + +E +DL+ +L+ E +++ H S+ + V
Sbjct: 921 ELEETHVSITQEKNDLALQLQ------------AEQDNLADAEERCHLLIKSKVQLEGKV 968
Query: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV-------QTEKLCLEKDN 1939
+++ ER D E + + + + +E E L+ D++ + + EK E
Sbjct: 969 KELS----ERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKV 1024
Query: 1940 ENKQKVIVCLEEELSVVTSERNQLR-------GELDTMSKKTTALDQLSEKMKEKTQELE 1992
+N + + L+E ++ +T E+ L+ G+L + +AL + +++++ ++LE
Sbjct: 1025 KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLE 1084
Query: 1993 -SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK 2051
S + E + A+ K + +L T S V++ +DK L+EKL+ + + LSL
Sbjct: 1085 CSLEQEKKLRMDTERAKRKLEGDLKLTQES-VADAAQDKQQLEEKLKKKDSELSQLSLRV 1143
Query: 2052 -------CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA 2104
+++ +I +L E L +E E+ +A + + ++ ++ LE L E+ E A
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELE-ELSERLEEA 1202
Query: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND---SLKDKVENLER 2161
S+ Q E + +R E R+R E +E H A R ++ + L ++V++L+R
Sbjct: 1203 GGASAGQREGCR-KREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR 1261
Query: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
Q E+ + + ++ ++ A VETL + + +E L + + E L +Q+ +
Sbjct: 1262 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQI---KEESKTAVEMLQNQLKELNEAVAALCGD 2278
Q L LLEEKE Q+ K + ++E L+ QL+E ++A +AL
Sbjct: 1322 ASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHA 1381
Query: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
+ ++ L EEE + + +++L ++ A+ + S++ AD ++ R
Sbjct: 1382 VQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW--------RSKYEADAIQ-RT 1432
Query: 2339 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT 2398
E LE ++ AL + ++ VE AK LE + +++E E++T
Sbjct: 1433 EELEEA-------KKKLALRLQEAEEGVEAANAKCS-------SLEKAKLRLQTESEDVT 1478
Query: 2399 NELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL- 2457
EL++ + L+ E L+E+ +++ +M+ + +E Q + + L + L
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRE----LEAAQRESRGLGTELFRLR 1534
Query: 2458 HNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG-LIQEVEDGKQK 2516
H +EA +A +E L+ E L + + + + Q S++G IQE+E K+
Sbjct: 1535 HGHEEALEA--------LETLKRENKNLQEEISDLTD-----QVSLSGKSIQELEKTKKA 1581
Query: 2517 LEKKDEEISRLKNQIQDQEQLVS--------KLSQVEGE-HQLWKEQNLELRNLTVELEQ 2567
LE + EI + + +L +LSQV+ E + E++ E NL ++
Sbjct: 1582 LEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQR 1641
Query: 2568 KIQVLQ-SKNASLQDTLEVLQSSYKNLE---NELELTKMDKMSFVEKVNKMTAKETELQR 2623
++ LQ S +A + E L+ K +E N+LEL ++ T + TE Q
Sbjct: 1642 AVESLQASLDAETRARNEALRLK-KKMEGDLNDLEL----------QLGHATRQATEAQA 1690
Query: 2624 EMHEMAQKTAELQEELSG--EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2681
M A+L+EE +G E+ RLA EL E+ ++ + + L E EL+ +L
Sbjct: 1691 ATRLM---QAQLKEEQAGRDEEQRLAAELH---EQAQALERRASLLAAELEELRAAL--- 1741
Query: 2682 HKDQVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQ----TYREKLTSKE 2736
+Q E+ ++ E E+ E RL+ ++ LL+ K+ E ++ E +
Sbjct: 1742 --EQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQLSGEVEEAAQERR 1798
Query: 2737 ECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA----- 2791
E K I EEL + T+ LE +KKT ++ + +E E+A
Sbjct: 1799 EAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGG 1857
Query: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQ---------------LQAAQEKQKTGTVMDTKV 2836
+ +++ L ++LE E + QK+ ++ A+E +K M V
Sbjct: 1858 KKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLV 1917
Query: 2837 DELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQD 2896
D+L +++K K EE ++A+ L KY + E+ +M ETQ +K
Sbjct: 1918 DKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQA-------NKLR 1970
Query: 2897 SRGSPLLGP 2905
+R LGP
Sbjct: 1971 ARTRDALGP 1979
Score = 154 bits (389), Expect = 1e-36
Identities = 224/1057 (21%), Positives = 446/1057 (42%), Gaps = 102/1057 (9%)
Query: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
N SW + F ++ L A E E L A+L ++ E + L
Sbjct: 875 NWSWMKLFFKMKPLL-----RSAQAEEELAALRAELRGLRGALAAAEAKRQE-------L 922
Query: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
EE +T E+N L +L ++ + + +LE E ++ E
Sbjct: 923 EETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVN 982
Query: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQA-------LSLTKCELENQIAQLN 2062
+ + L + +EL KD L+ L EK+ QA L+ L+ +A+L
Sbjct: 983 ADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLT 1042
Query: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
KEK+ L E+ Q L + E+ VS AL A + + L + E+ +LR E
Sbjct: 1043 KEKKAL---QEAHQQALGDLQAEEDRVS-ALTKAKLRLEQQVEDLECSLEQEKKLRMDTE 1098
Query: 2123 KLRVRIEADEK-KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181
+ + ++E D K Q +A+ +++++ + LK K L +L + E+++L L A+ K
Sbjct: 1099 RAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELS-QLSLRVEDEQL--LGAQMQK 1155
Query: 2182 AEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2241
+++ L+ + EE+ L+ + ++ ++++E +L E + +
Sbjct: 1156 -KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR 1214
Query: 2242 EKEQAEIQIKEESKTAV---EMLQNQLKELNEAVAALCGDQ-EIMKATEQSLDPPIEEEH 2297
++E +++ E + A E L+ AA G+Q + ++ Q L+ +E+
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE---KEKS 1271
Query: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL------------ 2345
+LR ++ L A +E + + + + E K +VE L+R+L
Sbjct: 1272 ELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT 1331
Query: 2346 ---EIARTNQEHAALEAENSKGE------VETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
E++R +E L ++ S+G+ +E L+ ++E +++ L V +R + +
Sbjct: 1332 ESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 2397 LTNELQKEQERISELEII----NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNE 2452
L + ++E E +EL+ + N+ + E + +Q E+ A + L +L+E E
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEE 1451
Query: 2453 RVAALH---NDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509
V A + + E K + Q S V LELE+A + K + L+ ++ ++
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDV-TLELERATSAAAALDKKQRH--LERALEERRRQ 1508
Query: 2510 VEDGKQKLEKKDEEISRLKNQI----QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL 2565
E+ +++LE E L ++ E+ + L ++ E++ +E+ +L +
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
+ IQ L+ +L+ +Q++ + E LEL + K + EL +
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALELEE----------TKTLRIQLELSQVK 1618
Query: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685
E+ +K AE EE + L Q +E +++S D E LKK ++ D
Sbjct: 1619 AEVDRKLAEKDEECA----NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDL 1674
Query: 2686 VEKEGKVREEIAEYQ--LRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQK 2743
+ G + E Q RL +A+ K + D ++ E+ + L + L++
Sbjct: 1675 ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAA-- 1732
Query: 2744 LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK 2803
E++ L+++ E+ S + Q L ++ + +N L +N + K L
Sbjct: 1733 -ELEELRAALEQGERSRRLAEQEL-------LEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 2804 QLEEEKEILQKELSQLQAAQEKQKTGTVMDT----KVDELTTEIKELKETLEEKTKEADE 2859
QL E E +E + + +K T M K + + ++ +K+TLE+ +E
Sbjct: 1785 QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Query: 2860 YLD--KYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
L+ + +L ++++K + + A L ++Q K
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKK 1881
Score = 134 bits (337), Expect = 1e-30
Identities = 207/1036 (19%), Positives = 415/1036 (40%), Gaps = 129/1036 (12%)
Query: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
++LE + +LKK+ + L E Q + KV+N E L RL + ++L+
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 81 KTKQKISHELQVKESQVNF----------QEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
+ Q+ +LQ +E +V+ Q L +Q +KL + +R K +LE +
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 1109
Query: 131 AAQS--ADVSLNPCNTPQKI---------FTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Q AD + + +K+ + + Q + +KE + E +
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169
Query: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
LEAE +A +A+ Q A R + + + Q+E ++ +RR
Sbjct: 1170 ELEAE-RAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR---EAELGRLRR 1225
Query: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
+ + E V R G + S + +L+ + ELR ++++L
Sbjct: 1226 ELEEAALRHEATVAALRRKQAEGAAELGEQV---DSLQRVRQKLEKEKSELRMEVDDLAA 1282
Query: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
++ + + + QL +AK+++ E ++ L + R + + S
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE 1342
Query: 360 LEQKLKKLTEDLSCQRQNAESARCSLEQKIK-----------------------EKEKEF 396
E + +L+ + Q+ E R LE++ K E+E E
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402
Query: 397 QEELSR----------QQRSFQTLD-----QECIQMKARLTQELQQAKNMHNVLQAELDK 441
Q EL R Q RS D +E + K +L LQ+A+ A+
Sbjct: 1403 QAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSS 1462
Query: 442 LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501
L K +L+ E+ +L RA A A K+ L R++EE +++ ++ E RE
Sbjct: 1463 LEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRE 1522
Query: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAV 560
L EL ++ ++ E +K +N + + + DL ++++ S+ LEK K A
Sbjct: 1523 SRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKA- 1581
Query: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
LE ++ Q L++ E +E +E+K L LEL +
Sbjct: 1582 --LEGEKSEIQAALEEAEGALEL---------EETKTLRIQLELSQV------------- 1617
Query: 621 CWKSENEKLLTQMESEKENL----QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS 676
K+E ++ L + + E NL Q + L+ L + +E + +E D +L
Sbjct: 1618 --KAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 1675
Query: 677 VEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
+++ H + + T+ M+ Q K E + + ++ + ++L Q + LE
Sbjct: 1676 LQLG--HATRQATEAQAATR---LMQAQLKEEQAGRDEEQRL------AAELHEQAQALE 1724
Query: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK--DASLVTNEDHQRSLLAFDQQPAMH 794
+ LL+ E+ + + + E R L + + +A+ N H ++ +Q+ +
Sbjct: 1725 RRASLLAAELEELRAALE----QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780
Query: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
A + GE ER E +A ++ ++A++ L+ ++ ++ L++ +
Sbjct: 1781 ADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAE-------ELKKEQDTSAHLERMKK 1833
Query: 855 ELVQIKGEIEENLMKAEQM----HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
L Q E++ L +AEQ + V + ++ +L+ + A Q AE L + E
Sbjct: 1834 TLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHE 1893
Query: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970
+ ++ L + E ++ + ++ L+ +K + E E++ +++ K + E
Sbjct: 1894 RRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE--EAEQQANTNLAKYRKAQHE 1951
Query: 971 -ELTQENGTLKEINAS 985
+ +E + E A+
Sbjct: 1952 LDDAEERADMAETQAN 1967
Score = 132 bits (331), Expect = 7e-30
Identities = 223/1122 (19%), Positives = 455/1122 (40%), Gaps = 141/1122 (12%)
Query: 11 GLPTRALQKIQELEGQLDKLKKEKQQRQFQLDS---------------------LEAALQ 49
G A K QELE + +EK QL + LE ++
Sbjct: 910 GALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVK 969
Query: 50 KQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKK 109
+ +++E+E+ +L ++L + C L+K + L E + E ++ + +
Sbjct: 970 ELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTE 1029
Query: 110 QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL-- 167
++ L++ + R E + Q+A Q A L ++ + LT ++ + EDL
Sbjct: 1030 EMAALDESVARLTKEKKALQEAHQQALGDLQ----AEEDRVSALTKAKLRLEQQVEDLEC 1085
Query: 168 ----KEKYNKEVEERKR-LEAEVKALQAKKASQTLPQATMNHR---------DIARHQAS 213
++K + E KR LE ++K Q A + + + ++
Sbjct: 1086 SLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVED 1145
Query: 214 SSVFSWQQEKTPSHLSSNSQ--RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFF 271
+ Q +K L + ++ + + +A +Q +R ++ +R +
Sbjct: 1146 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSER-LEEAGG 1204
Query: 272 DNSSSPHLLDQLKAQNQELRNKINELELRLQG-----HEKEMKG------QVNKFQELQL 320
++ + +A+ LR ++ E LR + K+ +G QV+ Q ++
Sbjct: 1205 ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQ 1264
Query: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
+LEK K EL + L + L R A ++ Y + K E+L Q +A +
Sbjct: 1265 KLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAST 1324
Query: 381 ARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD 440
R L+ + ELSR + L + + KA Q L++ L+ +L+
Sbjct: 1325 QRGRLQTE--------SGELSRLLEEKECLISQLSRGKALAAQSLEE-------LRRQLE 1369
Query: 441 KLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA- 499
+ + K L + ++ + + + + EL+R + + E +S E A
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 500 REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA 559
+ LE K + L +++ E AK +S E LQ + ++ +L LE+ A
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE--SEDVTLELERATSA 1487
Query: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL--------------LSALELK 605
A L+K++ + L++R E++ +L ++ES+ L L ALE
Sbjct: 1488 AAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETL 1547
Query: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV 665
K+E + L+EE + + S + K + ++E K+ L+ + + ++ L ++ + E
Sbjct: 1548 KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL--EEAEGALELEET 1605
Query: 666 RTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS-----DQKHQKEIEN 720
+TL + +E+ + +D K E + + Q+A S D + + E
Sbjct: 1606 KTL-----RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA 1660
Query: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
+ LK ++ G + DLE +L + + + + + A+ LK + A D
Sbjct: 1661 LRLK-KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ-------LKEEQA----GRDE 1708
Query: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
++ L A +H + + +E E R +Q ++ + + + L
Sbjct: 1709 EQRLAA-----ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLN 1763
Query: 841 SQKQMNSDLQKQCE----ELVQIKGEIEE---NLMKAEQMHQSFVAETSQRISKL--QED 891
N+ L Q + +L Q+ GE+EE +AE+ + + + + +L ++D
Sbjct: 1764 LLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD 1823
Query: 892 TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL 951
TSAH + +T LE +ELQ + E EQA ++ KK LE ++EL+ +E
Sbjct: 1824 TSAHLERMKKT---LEQTVRELQARLE--EAEQAALRGGKKQVQKLEAKVRELE--AELD 1876
Query: 952 SLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSI 1011
+ +KK ++ + K E +KE+ +++ NL + + + + + KS
Sbjct: 1877 AEQKKHAEALKGVRKHE--------RRVKELAYQAEEDRKNL-ARMQDLVDKLQSKVKSY 1927
Query: 1012 SELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
++ +Q+ L + + + +D ++ A+ + +KL
Sbjct: 1928 KRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKL 1969
Score = 124 bits (312), Expect = 1e-27
Identities = 212/1018 (20%), Positives = 410/1018 (40%), Gaps = 125/1018 (12%)
Query: 412 QECIQMKARLTQE-----LQQAKNMHNVLQAE--LDKLTSVKQQLENNLEEFKQKLCRAE 464
QE + +TQE LQ N+ AE L K QLE ++E ++L E
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979
Query: 465 QAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ---CLNQS-Q 520
+ + +L E+KK+ + LK + +E E ++KN+ + L++S
Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVA 1039
Query: 521 NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHH 580
+E KA + + L DLQ +++ L K KL + + +CS + KK
Sbjct: 1040 RLTKEKKALQEAHQQALGDLQA---EEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMD 1096
Query: 581 IEQLNDKLSKTEK-ESKALLSALELKKKEYEELKEEKTLFS--CWKSENEKLL-TQMESE 636
E+ KL K +++ A + K++ E+LK++ + S + E+E+LL QM+ +
Sbjct: 1097 TERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKK 1156
Query: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
+ LQ++ LE L+ ++ ++ + E LS + + +
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR 1216
Query: 697 KLAYMELQQKAEFSDQKHQKEIENMCLK----TSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
+ L+++ E + +H+ + + K ++L QV+ L+ Q L E +
Sbjct: 1217 EAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRME 1276
Query: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
DL A E+L S + T ED A + + A+ ++G + +E
Sbjct: 1277 VDDLAANVETLTRAKASAEKLCRTYEDQLSE--AKIKVEELQRQLADASTQRGRLQTESG 1334
Query: 813 ECR--LE-----ADQSPKNSAILQNRVDSLEFSLESQKQMNSD--------------LQK 851
E LE Q + A+ ++ L LE + + S L++
Sbjct: 1335 ELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 852 QCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911
Q EE + + E++ L KA AE +Q SK + D + E L +
Sbjct: 1395 QHEEEAEAQAELQRLLSKAN-------AEVAQWRSKYEADAIQRTEELEEAKKKLALR-- 1445
Query: 912 ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL-----LSETLSLEKKE--MSSIISL 964
LQ + VE A+ L+K+ L+ +++ L S +L+KK+ + +
Sbjct: 1446 -LQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEE 1504
Query: 965 NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLI 1024
+R+ EE+ +E + + L E L E ++ ++ L ++
Sbjct: 1505 RRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD---- 1560
Query: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084
L + +G + ++L + KA + + S+++ L E E + + +++ ++ E
Sbjct: 1561 LTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAE 1620
Query: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
KLA +E NL + ++L++ + D + +++EA LK+ KM+
Sbjct: 1621 VDRKLAEKDEECANLRRNHQRAVESLQASL-DAETRARNEALRLKK----------KMEG 1669
Query: 1145 EVNDL-LQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS- 1202
++NDL LQ + + + + ++++ E +R Q + S
Sbjct: 1670 DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1729
Query: 1203 ----LDSYNAQLVQLEAMLRNKELKLQESEK--------------EKECLQHELQTIRGD 1244
L+ A L Q E R E +L E+ + +K+ L+ +L + G+
Sbjct: 1730 LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 1789
Query: 1245 LETSNLQDMQSQEIS--GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1302
+E + + +++E + + D + AE EL Q+ +AHL+ +T + E
Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAE--------ELKKEQDTSAHLERMKKTLEQTVRE 1841
Query: 1303 LE---------------KICEILQAEKYELVTELN---DSRSECITATRKMAEEVGKL 1342
L+ K + L+A+ EL EL+ +E + RK V +L
Sbjct: 1842 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKEL 1899
Score = 122 bits (306), Expect = 6e-27
Identities = 211/1072 (19%), Positives = 438/1072 (40%), Gaps = 115/1072 (10%)
Query: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ---LEKAKVELIEKEKVLNK 338
+L+ + EL+ I++L+L L EKE + NK + L + L+++ L +++K L +
Sbjct: 991 KLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQE 1050
Query: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
+ QA A E ++ LT+ Q E CSLEQ EK+ +
Sbjct: 1051 A----------HQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQ-----EKKLRM 1095
Query: 399 ELSRQQRSFQTLDQECIQMKARLTQE-LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK 457
+ R +R ++ +LTQE + A L+ +L K S QL +E+ +
Sbjct: 1096 DTERAKRK--------LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQ 1147
Query: 458 QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
+ ++ + Q + EL EE++ E +Q+A LE + +++
Sbjct: 1148 LLGAQMQKKIKELQARAEELE---EELEAERAARARVEKQRAEAARELEELSERLEEAGG 1204
Query: 518 QSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA--VADLEKQRDCSQDLLK 575
S E + + + R+L+E + E ++ + K A A+L +Q D Q + +
Sbjct: 1205 ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQ 1264
Query: 576 KREHHIEQL----NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631
K E +L +D + E ++A SA +L + ++L E K E ++ L
Sbjct: 1265 KLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKV----EELQRQLA 1320
Query: 632 QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691
+++ LQ++ L L+ ++ + L + + + L L+ +S
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKEC-------LISQLSRGKALAAQSLEELRRQLEEESK 1373
Query: 692 EVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDR 751
A L+ + ++H++E E +L+ L + E+
Sbjct: 1374 AKSALAHAVQALRHDCDLLREQHEEEAEAQA-----------ELQRLLSKANAEVAQWRS 1422
Query: 752 CYQ-DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Y+ D E L + K L E+ A + +++ + + +E
Sbjct: 1423 KYEADAIQRTEELEEAKKKLALRLQEAEEGVE---------AANAKCSSLEKAKLRLQTE 1473
Query: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
+ LE +++ +A L + LE +LE +++ ++Q++ E + + L +
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533
Query: 871 EQMHQSFV--AETSQRISK-LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI 927
H+ + ET +R +K LQE+ S + V+ + +++ EK + L + QA +
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL 1593
Query: 928 QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN-GTLKEINASL 986
+E + + L E +QL LS K E+ ++ E L + + ++ + ASL
Sbjct: 1594 EEAEGALELEETKTLRIQL---ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASL 1650
Query: 987 N------QEKMNLIQKSESFANYID-EREKSISELSDQYKQEKLILLQRCEETGNAYEDL 1039
+ E + L +K E N ++ + + + ++ +L+ Q EE
Sbjct: 1651 DAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE-------- 1702
Query: 1040 SQKYKAAQEKNSKLECLLNECTSLCENRKN----ELEQLKEAFAKEHQEFLTKLAFAE-- 1093
+A +++ +L L+E E R + ELE+L+ A E E +LA E
Sbjct: 1703 ----QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAAL--EQGERSRRLAEQELL 1756
Query: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
E + L L L + L ++ + + +G +++ +E + K +K + D
Sbjct: 1757 EATERLNL-LHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMA 1815
Query: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
E+L K T + ++ + + +V+E ++ E ++ +L Q+ +L
Sbjct: 1816 EELKKEQDTSAHLERMK-KTLEQTVRELQARLE----------EAEQAALRGGKKQVQKL 1864
Query: 1214 EAMLRNKELKLQ-ESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKY 1272
EA +R E +L E +K E L+ + R E + + + ++ ++D + K
Sbjct: 1865 EAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKV 1924
Query: 1273 ISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDS 1324
S + ++ + ++L++ E+ ++ + + +L D+
Sbjct: 1925 KSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDA 1976
Score = 104 bits (259), Expect = 2e-21
Identities = 223/1075 (20%), Positives = 418/1075 (38%), Gaps = 159/1075 (14%)
Query: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
S Q E+ L AEL+ ++ L ++ +E++ + S I Q++N L L
Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVS-----------ITQEKNDLAL- 938
Query: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Q QD L E L SK + E K K+ E L++
Sbjct: 939 -----------QLQAEQDNLADAEERCHLLIK--SKVQLEGKV--------KELSERLED 977
Query: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
E+ + + + KL E E L+ I+ L+ L + + +V+ N
Sbjct: 978 EEEVNADLAARRRKL----EDECTELKKDIDDLKLTLAKAEKEKQATENKVK-------N 1026
Query: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
L+ E+ LD + +K A E Q+A Q + + + +L QVED
Sbjct: 1027 LTEEMA----ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVED 1082
Query: 735 LEHKLQLLSNEIMDKDRCYQDLHAEY--------------ESLRDLLKSKDASL----VT 776
LE L+ MD +R + L + + L + LK KD+ L +
Sbjct: 1083 LECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLR 1142
Query: 777 NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLE 836
ED Q LL Q + A + + +ER+ Q + + L+ + LE
Sbjct: 1143 VEDEQ--LLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200
Query: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
+ + +K+ EL +++ E+EE ++ E + + ++ ++L E + Q
Sbjct: 1201 EAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQ 1260
Query: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL----EDSLKELQLLSETLS 952
V LE ++ EL++ D + + K S L ED L E ++ E L
Sbjct: 1261 RV----RQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Query: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012
+ + S+ + E EL++ + + + L++ K Q E ++E K+ S
Sbjct: 1317 RQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKS 1376
Query: 1013 ELS--------------DQYKQ--EKLILLQRCEETGNA--------YE-DLSQKYKAAQ 1047
L+ +Q+++ E LQR NA YE D Q+ + +
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELE 1436
Query: 1048 EKNSKLECLLNE-----------CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN 1096
E KL L E C+SL E K L+ E E + + A +++
Sbjct: 1437 EAKKKLALRLQEAEEGVEAANAKCSSL-EKAKLRLQTESEDVTLELERATSAAAALDKKQ 1495
Query: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
++L LE ++ EM ++ E+ GL E+ L+ + + + L +EN+ L
Sbjct: 1496 RHLERALEE-RRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554
Query: 1157 MKVMKTKHECQNLESEPIRNSVKERES-ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA 1215
+ + + +L + I+ K +++ E + + ++ + L+ +QLE
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLEL 1614
Query: 1216 MLRNKELKLQESEKEKECL------QHELQTIRGDLETSNLQDMQSQEISGLKDCEI-DA 1268
E+ + +EK++EC Q +++++ L+ ++ + + ++ D
Sbjct: 1615 SQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDL 1674
Query: 1269 EEKYISGPHELSTSQNDNAHLQCSL----------QTTMNKLNE----LEKICEILQAEK 1314
E + + + +Q +Q L Q +L+E LE+ +L AE
Sbjct: 1675 ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAEL 1734
Query: 1315 YELVTELND-------SRSECITATRKM----AEEVGKLLNEVKILNDDSGLLHGELVED 1363
EL L + E + AT ++ ++ G LLN+ K L D L GE+ E
Sbjct: 1735 EELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQLSGEVEEA 1793
Query: 1364 IPGGEFGEQPNEQHPVSLAPL-----DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
E+ ++ A + E ++ HL K ++ ELQ + ++E
Sbjct: 1794 AQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARL--EEAEQ 1851
Query: 1419 KILH---DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE 1470
L Q ++ +K+ EL+ +D+ + ++ +R + VKE+ EE
Sbjct: 1852 AALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHE-RRVKELAYQAEE 1905
Score = 92.4 bits (228), Expect = 6e-18
Identities = 231/1162 (19%), Positives = 448/1162 (38%), Gaps = 170/1162 (14%)
Query: 854 EELVQIKGEI----------EENLMKAEQMHQSFVAETSQRISKLQE------DTSAHQN 897
EEL ++ E+ E + E+ H S E + +LQ D +
Sbjct: 896 EELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCH 955
Query: 898 VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE 957
++ ++ LE K KEL ++++E E+ +L LED EL+ + L L +
Sbjct: 956 LLIKSKVQLEGKVKEL---SERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAK 1012
Query: 958 MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
+ +++ LT+E L E A L +EK L + + + E +S L+
Sbjct: 1013 AEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT-- 1070
Query: 1018 YKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA 1077
+ KL L Q+ E+ + E + + KLE L + + +QL+E
Sbjct: 1071 --KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEK 1128
Query: 1078 FAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE 1137
K+ E L L +E +Q L ++M ++ A L++E+ +
Sbjct: 1129 LKKKDSEL-----------SQLSLRVED-EQLLGAQMQKKIKELQARAEELEEELEAERA 1176
Query: 1138 EQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLE 1197
+ +++K+ + +E E+L + + E S R ++RE+E + + +LE
Sbjct: 1177 ARARVEKQRAEAARELEELSE----RLEEAGGASAGQREGCRKREAELGRL----RRELE 1228
Query: 1198 VKEISLDSYNAQL--------VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSN 1249
+ ++ A L +L + + + Q+ EKEK L+ E+ + ++ET
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288
Query: 1250 LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL--EKIC 1307
++++ + ++ + + EL D + + LQT +L+ L EK C
Sbjct: 1289 RAKASAEKLCRTYEDQLSEAKIKV---EELQRQLADASTQRGRLQTESGELSRLLEEKEC 1345
Query: 1308 EILQAEKYELVTELNDSRSECITATRKMAEEVGK----LLNEVKILNDDSGLLHGELVED 1363
I Q + + + ++ + R+ EE K L + V+ L D LL + E
Sbjct: 1346 LISQLSRGKALA------AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEE- 1398
Query: 1364 IPGGEFGEQPNEQHPVSLA-----------PLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412
E Q Q +S A D E L + K++ + E +E
Sbjct: 1399 ----EAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVE 1454
Query: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL 1472
+ ++ L ++ ++ ++ ++ + L R+ + L E + EE +
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL--EERRRQEEEM 1512
Query: 1473 VPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQ 1532
L ++ LG F + G L LE N+ +LQ
Sbjct: 1513 QRELEAA----QRESRGLGTELFRL----RHGHEEALEALETLKRENK---------NLQ 1555
Query: 1533 EENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM-ESQGIMKNKEIQ--------- 1582
EE + S K ++ELE + +++ + E++G ++ +E +
Sbjct: 1556 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELS 1615
Query: 1583 ----ELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS-LE 1637
E+++ L+ + +E LR+ + E Q L + T L +KK L+ LE
Sbjct: 1616 QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 1675
Query: 1638 LEVARLQLQGLDLSSRS-LLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDK 1696
L++ Q + + + L+ ++ GR+E ++ E H+ Q ++
Sbjct: 1676 LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE----------LHEQAQALER 1725
Query: 1697 DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNA 1756
A +L ++ E A GE S + E + ++E ++ L
Sbjct: 1726 RA----SLLAAELEELRAALEQGERSRRLA---------EQELLEATERLNLLHSQNTGL 1772
Query: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENL----RLLHVIEDRDRKVESLLNEMKELDSKLH 1812
L L + D+ L V+E + E + I D E L KE D+ H
Sbjct: 1773 LNQKKKL--EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEEL---KKEQDTSAH 1827
Query: 1813 LQEV-----QLMTKIEACIEL---------EKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
L+ + Q + +++A +E +K V +L+ + +L +L+ H E L+
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 1859 RVETSEGLNSDLEMHADKSSR-----EDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
V E +L A++ + +D+ D + S+K +F + E + + ++
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRK 1947
Query: 1914 IEHEALYLE--ADLEVVQTEKL 1933
+HE E AD+ Q KL
Sbjct: 1948 AQHELDDAEERADMAETQANKL 1969
Score = 81.6 bits (200), Expect = 1e-14
Identities = 127/572 (22%), Positives = 248/572 (43%), Gaps = 57/572 (9%)
Query: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEA---ALQKQKQKVENEKTEGT 63
+W+ A+Q+ +ELE KL Q+ + +++ A +L+K K +++ TE
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQ---TESE 1475
Query: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
++ E +R +L+K ++ + L+ + Q + +L + +++ L EL R +
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRH 1535
Query: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE-ERKRLE 182
E + +A ++ + N ++I + LT SG ++L EK K +E E+ ++
Sbjct: 1536 GHEEALEALET--LKRENKNLQEEI--SDLTDQVSLSGKSIQEL-EKTKKALEGEKSEIQ 1590
Query: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP--SHLSSNSQR------ 234
A AL+ + + L + + Q + V EK ++L N QR
Sbjct: 1591 A---ALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQ 1647
Query: 235 ----TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD-QLKAQNQE 289
R A + E + LQ+G A + ++ L+ QLK +E
Sbjct: 1648 ASLDAETRARNEALRLKKKMEGDLNDLELQLG--HATRQATEAQAATRLMQAQLK---EE 1702
Query: 290 LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
+ E L + HE + + + L +LE+ + L + E+ EL+ T +
Sbjct: 1703 QAGRDEEQRLAAELHE-QAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1761
Query: 350 YDQASTKYTALEQKLKKLTED---LSCQRQNAESARCSLEQKIK----------EKEKEF 396
+ ++ T L + KKL D LS + + A R E+K K E+ K+
Sbjct: 1762 LNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821
Query: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Q+ + +R +TL+Q +++ARL +E +QA + ++ KL + ++LE L+
Sbjct: 1822 QDTSAHLERMKKTLEQTVRELQARL-EEAEQAALRGG--KKQVQKLEAKVRELEAELDAE 1878
Query: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
++K A + + + + EL EE +K NL + V L++++K+ K+
Sbjct: 1879 QKKHAEALKGVRKHERRVKELAYQAEEDRK--NLARMQD-----LVDKLQSKVKSYKRQF 1931
Query: 517 NQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
+++ A AK + L D +E+ + E
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAE 1963
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.319
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,130,742
Number of Sequences: 37866
Number of extensions: 5167142
Number of successful extensions: 85036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 786
Number of HSP's successfully gapped in prelim test: 1687
Number of HSP's that attempted gapping in prelim test: 20101
Number of HSP's gapped (non-prelim): 26617
length of query: 3114
length of database: 18,247,518
effective HSP length: 121
effective length of query: 2993
effective length of database: 13,665,732
effective search space: 40901535876
effective search space used: 40901535876
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.