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Search of human proteins with 55769587
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55769587 probable nucleolar complex protein 14 [Homo
sapiens]
(857 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55769587 probable nucleolar complex protein 14 [Homo sapiens] 1697 0.0
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 73 1e-12
gi|148746195 trichohyalin [Homo sapiens] 65 2e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 60 9e-09
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 3e-08
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 59 3e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 58 4e-08
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 58 4e-08
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 58 4e-08
gi|18093112 ABT1-associated protein [Homo sapiens] 58 4e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 57 1e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 57 1e-07
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 56 1e-07
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 56 2e-07
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 55 2e-07
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 55 2e-07
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 55 2e-07
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 55 2e-07
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 55 2e-07
gi|31982906 cingulin-like 1 [Homo sapiens] 55 2e-07
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 55 3e-07
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 55 4e-07
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 55 4e-07
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 55 4e-07
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ... 54 5e-07
gi|217330641 IWS1 homolog [Homo sapiens] 54 5e-07
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 6e-07
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 53 1e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 53 1e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 53 1e-06
>gi|55769587 probable nucleolar complex protein 14 [Homo sapiens]
Length = 857
Score = 1697 bits (4394), Expect = 0.0
Identities = 857/857 (100%), Positives = 857/857 (100%)
Query: 1 MAKAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRA 60
MAKAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRA
Sbjct: 1 MAKAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRA 60
Query: 61 RALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYN 120
RALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYN
Sbjct: 61 RALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYN 120
Query: 121 LNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG 180
LNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG
Sbjct: 121 LNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG 180
Query: 181 EEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSE 240
EEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSE
Sbjct: 181 EEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSE 240
Query: 241 NRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGK 300
NRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGK
Sbjct: 241 NRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGK 300
Query: 301 DEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEE 360
DEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEE
Sbjct: 301 DEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEE 360
Query: 361 EGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRD 420
EGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRD
Sbjct: 361 EGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRD 420
Query: 421 ELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEY 480
ELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEY
Sbjct: 421 ELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEY 480
Query: 481 VGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAAL 540
VGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAAL
Sbjct: 481 VGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAAL 540
Query: 541 PGLDVLIYLKITGLLFPTSDFWHPVVTPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLE 600
PGLDVLIYLKITGLLFPTSDFWHPVVTPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLE
Sbjct: 541 PGLDVLIYLKITGLLFPTSDFWHPVVTPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLE 600
Query: 601 YVALSQRFIPELINFLLGILYIATPNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQ 660
YVALSQRFIPELINFLLGILYIATPNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQ
Sbjct: 601 YVALSQRFIPELINFLLGILYIATPNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQ 660
Query: 661 QSSLSLRWASRLRAPTSTEANHIRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLT 720
QSSLSLRWASRLRAPTSTEANHIRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLT
Sbjct: 661 QSSLSLRWASRLRAPTSTEANHIRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLT 720
Query: 721 DHLADCSHPQELQELCQSTLTEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRKQ 780
DHLADCSHPQELQELCQSTLTEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRKQ
Sbjct: 721 DHLADCSHPQELQELCQSTLTEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRKQ 780
Query: 781 GSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSL 840
GSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSL
Sbjct: 781 GSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSL 840
Query: 841 ATQEGEWKALKRKKFKK 857
ATQEGEWKALKRKKFKK
Sbjct: 841 ATQEGEWKALKRKKFKK 857
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 73.2 bits (178), Expect = 1e-12
Identities = 71/345 (20%), Positives = 154/345 (44%), Gaps = 29/345 (8%)
Query: 98 EEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLS 157
++K K+ ++R EK + L E EEL G+ +K + + + + T+
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEEL-ETGKKDQSKQKESQRKFEEETVKSKVTVD 288
Query: 158 AEL-----------TAAHFGGGGGLLHK-KTQQEGEEREKPKSRKE--------LIEELI 197
+ TAA G K K +++GE+ EK K +K+ ++E +
Sbjct: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
Query: 198 AKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMV 257
AK K+E+ ++ + E+ ++ E+L+ KE + L + E R++K++ + + + +
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERL------EQEKRERKKQKEKERKERLK 402
Query: 258 RELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKK-PKHMSADD 316
+E K+Q R + EA L + + + + L + ED+ KK P+ + + +
Sbjct: 403 KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
Query: 317 LNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSP 376
+++ L + K V+ E+ ++ D ++ E +S E+TE+ +
Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMAS-DEETEKVEGN 521
Query: 377 DSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDE 421
H++++ N E EEE E+ +E ++ + G+ + ++
Sbjct: 522 KVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566
Score = 48.9 bits (115), Expect = 2e-05
Identities = 73/371 (19%), Positives = 148/371 (39%), Gaps = 53/371 (14%)
Query: 65 KRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNED 124
K T+ +E+ +DK + + ++ N S E++ + + ++ K +Y+ ++D
Sbjct: 82 KPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS--EELEDKDSKSKKTAKPKVEMYSGSDD 139
Query: 125 EELTHY--GQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGG-----LLHKKTQ 177
++ + ++ +K N D + ED E + + G G L +
Sbjct: 140 DDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKG 199
Query: 178 QEGEEREKPKSRKELIEE---------LIAKSKQEKRERQAQREDALELTEKLDQDWKEI 228
Q+ ++ KP E E +A+ K EK+ER+ ++ D E KL + KE
Sbjct: 200 QKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD--EEKAKL-RKLKEK 256
Query: 229 QTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRK 288
+ L +T K + +KE + + + ++ + P++ K E A E+ K
Sbjct: 257 EEL---ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 289 LEAERLRRMLGKDEDENVKK--PKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQE 346
+ ++ ++ K+E E KK P + + +
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALA------------------------ 349
Query: 347 EQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKG 406
+ KE + + EEE E+ E + L+ E E +++ EK KE+ + GK
Sbjct: 350 -KLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKR-ERKKQKEKERKERLKKEGK- 406
Query: 407 LISGKERAGKA 417
L++ +R +A
Sbjct: 407 LLTKSQREARA 417
Score = 41.2 bits (95), Expect = 0.004
Identities = 66/333 (19%), Positives = 131/333 (39%), Gaps = 47/333 (14%)
Query: 55 PGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHE 114
P + +A+++ L +E + + + R KR E + EE++ +Q E
Sbjct: 336 PSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERL-------EQEKRE 388
Query: 115 KKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHK 174
+K E L G+ L S +A R + +L A G + K
Sbjct: 389 RKKQKEKERKERLKKEGKLLTK---------SQREARARAEATLKLLQAQ---GVEVPSK 436
Query: 175 KTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSH 234
+ + + K RK++ ++L +K E E A A+E+ E+ + +E +
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA----AVEVMEQGVPEKEETPPPV-- 490
Query: 235 KTPKSENRDKKEKPKPDAYDMMVRE----------LGFEMKAQPSNRMKTEAELAKEEQE 284
+ E + E D ++ M + + E+K P + E E ++E+
Sbjct: 491 ---EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
Query: 285 HLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEED- 343
+ E G +EDE V +D+ + G LDK + +S D + + ++D
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKV-------SDEKDSGKTLDKKPSKEMS-SDSEYDSDDDR 599
Query: 344 VQEEQSKEASDPESNEEEGDSSGGEDTEESDSP 376
+EE++ + + + + S +TE+ +P
Sbjct: 600 TKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAP 632
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 65.5 bits (158), Expect = 2e-10
Identities = 86/423 (20%), Positives = 177/423 (41%), Gaps = 40/423 (9%)
Query: 61 RALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMM-----KRFALEQQRHHEK 115
+ L+++ + LL E E+ + R+K++ E EE+++ KR E +R + K
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQE-REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 116 KSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKK 175
K E++ L + E+ + + ++ L E +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR------RRQEL 1076
Query: 176 TQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHK 235
+Q +E E + ++L+ E K ++++RERQ + E+ EL ++ +Q +E + +
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE--ELQQEEEQLLREEREKRRRQ 1134
Query: 236 TPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRM-KTEAELAKEEQEHLR----KLE 290
+ + R+++E + + + ++RE + + Q R + E EL +EE++ LR K
Sbjct: 1135 ELERQYREEEEVQQEE--EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 291 AERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVE----EDVQE 346
ER R+ ++E + K+ + +D + + + +D K+ + E ++
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 347 EQSKEASDPESNE-------EEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQ 399
+ + D +S + E+ + ++ D H E +E EE+ E +++
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 400 RQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNH 459
+ K L+ +ER K R E F E LL E+ L ER +K
Sbjct: 1313 KSQEEKQLLR-EEREEKRRRQETDRKFREEEQ-------LLQEREEQPLRRQERDRKFRE 1364
Query: 460 PSL 462
L
Sbjct: 1365 EEL 1367
Score = 60.1 bits (144), Expect = 9e-09
Identities = 76/341 (22%), Positives = 147/341 (43%), Gaps = 17/341 (4%)
Query: 63 LRKRTQTLLKEYKE-----RDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKS 117
LRK Q L +E +E R+K +R + EE+ + R E++R E++
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 118 IYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQ 177
Y +D++L + L E + E + EL K+ +
Sbjct: 959 QYR--KDKKLQQKEEQLLGEEPEKR---RRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 178 QEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEI--QTLLSHK 235
QE E + + K + EE + + ++EKR Q +RE E+L Q+ +++ + + +
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQ-ERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 236 TPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLR 295
+ E + +KE+ + ++RE + + Q R E E ++E+E L + E E+ R
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 296 RM-LGKD--EDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEA 352
R L + E+E V++ + + + + +R+ ++ + E+ ++EEQ K
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 353 SDPESN-EEEGDSSGGEDTEESDSPDSHLDLESNVESEEEN 392
+ E EE + + + D DL+ E E+EN
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Score = 56.6 bits (135), Expect = 1e-07
Identities = 75/390 (19%), Positives = 160/390 (41%), Gaps = 43/390 (11%)
Query: 64 RKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNE 123
RKR L KE ++ + R + E + + ++R L ++R E++ L
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQL----RKLERQELRRERQEEEQQQQRLRR 302
Query: 124 DEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEER 183
+++L + E+ + + + ++R E ++ ++E EER
Sbjct: 303 EQQLRRKQE-----EERREQQEERREQQERREQQEERR-----------EQQLRREQEER 346
Query: 184 EKPKSRKELIEE-----LIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPK 238
+ + R+E EE L + ++E+RE+Q +RE L ++L ++ Q L + +
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE----QQLRREQQLR 402
Query: 239 SENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRML 298
E + ++E+ +L E + + +++ E E + EQ+H ++ +RL+R
Sbjct: 403 REQQLRREQ-----------QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 299 GKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESN 358
+ D ++ + + L +D + K+ EE+ +E+Q +
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQLRRE 510
Query: 359 EEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKAT 418
+EE + EE + L E + E+E + +R+ + + + R +
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR--LEQERREQRLK 568
Query: 419 RDELPYTFAAPESYEELRSLLLGRSMEEQL 448
R++ + EE R L R EE+L
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERL 598
Score = 54.3 bits (129), Expect = 5e-07
Identities = 64/325 (19%), Positives = 140/325 (43%), Gaps = 51/325 (15%)
Query: 79 KSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIE 138
K ++ +D+R E P ++ ++ +++R ++ L E EE + + L +
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 139 KHN---DIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEE 195
+ ++ + ++R AE G H+ + EE+ + R+EL+E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKG----HETEEFPDEEQLR---RRELLE- 217
Query: 196 LIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDM 255
L K ++EK++++ +R+D + E+ +++W++ +T+L K E + ++E+P+
Sbjct: 218 LRRKGREEKQQQRRERQDRV-FQEEEEKEWRKRETVLR----KEEEKLQEEEPQRQ---- 268
Query: 256 MVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSAD 315
REL +EE+E LRKLE + LRR ++E + + +
Sbjct: 269 --REL-------------------QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 316 DLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDS 375
+ ++RR + + E+ + EQ +E + + E+ + + E +
Sbjct: 308 RKQE------EERR----EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 376 PDSHLDLESNVESEEENEKPAKEQR 400
L E E ++ +EQ+
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQ 382
Score = 53.9 bits (128), Expect = 6e-07
Identities = 62/285 (21%), Positives = 128/285 (44%), Gaps = 15/285 (5%)
Query: 177 QQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKT 236
+++ + RE+ + +E EE + QE+R Q QR D + +L+++ K + L K
Sbjct: 837 EEQLQRRERAQQLQE--EEDGLQEDQERRRSQEQRRDQ-KWRWQLEEERKRRRHTLYAKP 893
Query: 237 PKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRR 296
E K+++ + + + RE + + Q R E E ++E+E L + E E+ RR
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 297 MLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQS----KEA 352
++ + +K K + + + + ++ ++R ++ K EE++Q+E+ +E
Sbjct: 954 ---QERERQYRKDKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 353 SDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKE 412
E E ++ ++ + + E E E + +E+ Q + L+ G+E
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL-GEE 1067
Query: 413 RAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKC 457
R + R EL + E ++ LL R E+ ER ++C
Sbjct: 1068 RETR-RRQELERQYRKEEELQQEEEQLL-REEPEKRRRQERERQC 1110
Score = 49.7 bits (117), Expect = 1e-05
Identities = 66/351 (18%), Positives = 156/351 (44%), Gaps = 43/351 (12%)
Query: 65 KRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNED 124
+R Q L +E + R + + R++ E + +E+ +R EQ+ + L +
Sbjct: 408 RREQQLRREQQLRREQQLRREQE-EERHEQKHEQERREQRLKREQEERRDW-----LKRE 461
Query: 125 EELTHYGQSLADIEKHNDIVDSDSDAEDRGT---LSAELTAAHFGGGGGLLHKKTQQEGE 181
EE + Q E+ + D + E R L E ++ QQE
Sbjct: 462 EETERHEQ-----ERRKQQLKRDQEEERRERWLKLEEE-------------ERREQQERR 503
Query: 182 EREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSEN 241
E++ + ++E E+ + + ++E+R +Q R + +L + ++ +++ K + E
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQEERREQLLKREEEKRLEQER 562
Query: 242 RDKK-EKPKPDAYDMMVR--ELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRML 298
R+++ ++ + + D +++ E + + + + E L +EE E L + ER + L
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE--QEERREQRL 620
Query: 299 GKDEDENVKKPKHMSADDLND----GFVLDKDDRR--LLSYKDGKMNVEEDVQEEQSKEA 352
++E E ++ + + +++ + ++ +RR L ++ + +E+ ++ E +E
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 353 SDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEEN--EKPAKEQRQ 401
+ E EEE + + + +S P LES ++ + +P K++ Q
Sbjct: 681 REQELAEEEQEQA--RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Score = 47.8 bits (112), Expect = 4e-05
Identities = 86/381 (22%), Positives = 160/381 (41%), Gaps = 64/381 (16%)
Query: 33 EVKVNRQ----KFQILGRKTRHDVGLPGVSRARALRKRT-QTLLKEYKERDKSNVFRDKR 87
E KV RQ KF ++ R G + + R + R + LL+E +E+ RD++
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 88 FGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSD 147
F E EE ++R EQQ H++ + E+E+L G+ + D
Sbjct: 1645 FLE-------EEPQLRRQEREQQLRHDRDRKFR--EEEQLLQEGEEQQLRRQERD----R 1691
Query: 148 SDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRER 207
E+ L + F L ++ Q +E E+ K R+E E+L +++QE+ R
Sbjct: 1692 KFREEEQQLRRQERERKF------LQEEQQLRRQELER-KFREE--EQLRQETEQEQLRR 1742
Query: 208 QAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQ 267
Q + LE E+L + +E Q + + RD+K + + + ++++Q
Sbjct: 1743 QERYRKILE-EEQLRPEREEQQL-------RRQERDRKFREEEQLRQEREEQ---QLRSQ 1791
Query: 268 PSNR-MKTEAELAKE-EQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDK 325
S+R + E +L +E E++ LR + + R E+E ++ L++
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRW----EEEQLQ---------------LEE 1832
Query: 326 DDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESN 385
++RL +D + EE ++ + E +EE E E + H+ +
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQE--RERKLREEHIRRQ-- 1888
Query: 386 VESEEENEKPAKEQRQTPGKG 406
+ EE+ + E + GKG
Sbjct: 1889 -QKEEQRHRQVGEIKSQEGKG 1908
Score = 47.4 bits (111), Expect = 6e-05
Identities = 67/348 (19%), Positives = 144/348 (41%), Gaps = 41/348 (11%)
Query: 64 RKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNE 123
++R Q L ++Y+E ++ ++ E E + R E QR K+ + ++
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 124 DEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQE---- 179
+L + EK N + D+ + R L +++QQ+
Sbjct: 1220 RSDLKWQWEP----EKENAVRDNKVYCKGRENEQFRQLE-----DSQLRDRQSQQDLQHL 1270
Query: 180 -GEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPK 238
GE++E+ + ++ + + ++R+R E+ LE E+ + ++ ++ + +
Sbjct: 1271 LGEQQERDREQE--------RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 239 SENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEE---QEHLRKL--EAER 293
E +K+ + + D +L E + QP R + + + +EE QE RK E +R
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 294 LRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEAS 353
LRR + E + +K+ + + + +++L +D K EE ++ S++
Sbjct: 1383 LRRQ--ERERKFLKEEQQLRCQE---------REQQLRQDRDRKFREEE---QQLSRQER 1428
Query: 354 DPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQ 401
D + EEE E + + L E + + EE + + + Q
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Score = 47.4 bits (111), Expect = 6e-05
Identities = 83/424 (19%), Positives = 173/424 (40%), Gaps = 49/424 (11%)
Query: 59 RARALRKRTQTLLKEYKER---DKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEK 115
R R R+ Q + ++ +ER ++ R +R ++ EE+ + + EQQ H ++
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR-----EEEQLLQEREEQQLHRQE 1482
Query: 116 KSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHK- 174
+ L E+++L + E+ + S +R L E L +
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQ-----ELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 175 ---KTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTE----KLDQDWKE 227
+ Q+ G++R + + RK EE + + ++E++ + +R+ L E + +Q+ K
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 228 IQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLR 287
++ + + + + ++E+ + D +L E + Q +R + + + +EE + LR
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFRED---EQLLQEREEQQLHRQERDRKFLEEEPQ-LR 1653
Query: 288 KLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEED---V 344
+ E E + L D D ++ + + + + DR+ + E + +
Sbjct: 1654 RQERE---QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 345 QEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVES--EEENEKPAKEQRQT 402
QEEQ + E E E+ ++ L + EEE +P +E++Q
Sbjct: 1711 QEEQQLRRQELERKFRE------EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ- 1763
Query: 403 PGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSM-EEQLLVVERIQKCNHPS 461
+ +ER K +E ++LRS R EE+ L ER ++ P
Sbjct: 1764 -----LRRQERDRKFREEE---QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 462 LAEG 465
+G
Sbjct: 1816 QRDG 1819
Score = 44.7 bits (104), Expect = 4e-04
Identities = 80/427 (18%), Positives = 163/427 (38%), Gaps = 46/427 (10%)
Query: 59 RARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQ---RHHEK 115
R +R Q L +E +ER + + R + + E+++ + ++ + E+
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 116 KSIYNLNEDEELTHYGQSLAD--IEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLH 173
K + ++ L + D +++ + E L L L
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER---LEQ 612
Query: 174 KKTQQEGEEREKPKS--RKELI---EELIAKSKQEKRERQAQREDAL---ELTEKLDQ-- 223
++ +++ +RE+P+ R++L+ E+ + +Q +RE+Q +RE L E E+L+Q
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 224 -----DWKEIQTLLSHKTPKSENRDKKEKPK------PDAYDMMVRELGFEMKAQPSNRM 272
+ + Q L + ++ R K PK +A + K + R
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 273 KTEAELAKEEQEHLRKLEAERLRRMLGKDEDE-------NVKKPKHMSADDLNDGFVLDK 325
+ + E + + L+ E ER R ++E ++ L+ L +
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 326 DDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESN 385
R L ++ + + + EE+ KE + E E + E+ E+ + L+
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 386 VESEEENEKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSME 445
+ +E+++ + Q Q + E K R L +A P E+LR E
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL---YAKPALQEQLRK-------E 902
Query: 446 EQLLVVE 452
+QLL E
Sbjct: 903 QQLLQEE 909
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 60.1 bits (144), Expect = 9e-09
Identities = 71/330 (21%), Positives = 135/330 (40%), Gaps = 49/330 (14%)
Query: 91 YNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDA 150
Y N EE+ A E++R ++ + E+E L GQ +E + D +A
Sbjct: 27 YQRNDDDEEEA----ARERRRRARQERLRQKQEEESL---GQVTDQVEVNAQNSVPDEEA 79
Query: 151 EDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQ 210
+ T TQ EG++ R EE K QE ERQ +
Sbjct: 80 KTTTT-------------------NTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 211 REDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSN 270
+ + D + + T ++E +K+EK + + E K+ N
Sbjct: 121 FDPTIT-----DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
Query: 271 RMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRL 330
+ E KE++E + E + R +G+++ E + + K + +++ +
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTES----------QEETVV 225
Query: 331 LSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEE 390
+S K+G+++ EE QEE+ ++ SD S+ E+ + ED E +++ + L+ E +
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE---EDKERAEAERARLEAEERERIKA 282
Query: 391 ENEKPAKEQRQTPGKGLISGKERAGKATRD 420
E +K ++R I +E+A R+
Sbjct: 283 EQDKKIADER-----ARIEAEEKAAAQERE 307
Score = 48.1 bits (113), Expect = 3e-05
Identities = 69/356 (19%), Positives = 147/356 (41%), Gaps = 33/356 (9%)
Query: 76 ERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLA 135
E + V + G+ +S P+++ + ++ HHEK ED+E ++
Sbjct: 218 ESQEETVVMSLKNGQISSE-EPKQEEEREQGSDEISHHEKME----EEDKERAEAERARL 272
Query: 136 DIEKHNDI-VDSDSD-AEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELI 193
+ E+ I + D A++R + AE AA ++ ++E EERE+ + ++
Sbjct: 273 EAEERERIKAEQDKKIADERARIEAEEKAA--------AQERERREAEERERMREEEKRA 324
Query: 194 EELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAY 253
E + K+E++ +R+ E ++ ++ + I+ + + R + E+ +
Sbjct: 325 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE-EEKRAAEERQRARAEEEEKAKV 383
Query: 254 DMMVRELGFEMKAQPSNRMKTEAELAKEEQE----HLRKLEAERLRRMLGKDEDENVKKP 309
+ R E K K + E +++ E + +K + ++L+ + K + E
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 310 KHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGE- 368
+ L + DK + KD K+ +++ +EE K D + E S GE
Sbjct: 444 VQAKREKLQE----DKPTFKKEEIKDEKIKKDKEPKEE-VKSFMDRKKGFTEVKSQNGEF 498
Query: 369 ---DTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDE 421
+ +++ S ++V+++E P E GK L + R G+ +E
Sbjct: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE----AGKRLEELRRRRGETESEE 550
Score = 46.2 bits (108), Expect = 1e-04
Identities = 88/396 (22%), Positives = 158/396 (39%), Gaps = 81/396 (20%)
Query: 59 RARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMM-----KRFALEQQRHH 113
RA A R R E +ER++ +DK+ + + + EEK +R A E++R
Sbjct: 264 RAEAERARL-----EAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 114 EKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLH 173
E++ E+ + + A E+ + AE+R + E A
Sbjct: 319 EEEK--RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA------AEER 370
Query: 174 KKTQQEGEER---EKPKSRKELIEELIA----KSKQEKRERQAQ---------REDALEL 217
++ + E EE+ E+ K K+L E+ A K K EK E++ + +ED L+
Sbjct: 371 QRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQT 430
Query: 218 T-----------------EKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVREL 260
EKL +D + + K E K ++PK + M R+
Sbjct: 431 AVLKKQGEEKGTKVQAKREKLQED----KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Query: 261 GF-EMKAQPS--------------NRMKTEAELAKEEQEHLRKLEA----ERLRRMLGKD 301
GF E+K+Q +R A + +E E ++EA E LRR G+
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 546
Query: 302 EDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEE 361
E E +K K + L+ ++ L ++ + V E+ ++ + +E +D + EEE
Sbjct: 547 ESEEFEKLKQKQQE-----AALELEE--LKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
Query: 362 GDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAK 397
E+ E + + + + +++KP K
Sbjct: 600 EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/428 (21%), Positives = 163/428 (38%), Gaps = 64/428 (14%)
Query: 163 AHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLD 222
+H GG H + +++ E E+ K +E ++ + +++KR R+ RE + ++L+
Sbjct: 79 SHSAEGGK--HARVKEKEREHERRKRHREEQDKARREWERQKR-REMAREHSRRERDRLE 135
Query: 223 QDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEE 282
Q ++ + + + E R++KE+ + RE E+ A + ++ K
Sbjct: 136 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 195
Query: 283 QEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV-- 340
R R LG D + VK+ K D L+D + +R+ S +
Sbjct: 196 HWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGS 254
Query: 341 --EEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKE 398
EE+ +EE+ +E S E E + E+ EE +S E + E E E E
Sbjct: 255 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 314
Query: 399 QRQTPGKGLI--------------SGKERAGKAT-----------------------RDE 421
+R+ L+ +E G+ T + E
Sbjct: 315 ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 374
Query: 422 LPYTFAAPE---SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF- 476
LP A + S EE + L R E VV R + + + K+EK GF
Sbjct: 375 LPKYLPALQGCRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFP 432
Query: 477 --LLEYVGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIET 534
L + + P++ + ++VV S D I V+ H+++ ++ET
Sbjct: 433 ITSLREINTILKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMET 482
Query: 535 KGRAALPG 542
+ LPG
Sbjct: 483 MKQPFLPG 490
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/260 (21%), Positives = 114/260 (43%), Gaps = 24/260 (9%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLL 232
H+K ++ E+R E + K K+ + ER+ + E +K ++W+ +
Sbjct: 65 HRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHR---EEQDKARREWERQKRRE 121
Query: 233 SHKTPKSENRDKKEK-PKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEA 291
+ RD+ E+ + + +RE E + Q + AE ++E+E R++ A
Sbjct: 122 MAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR--AEERRKEREARREVSA 179
Query: 292 ERLRRMLGKDEDENVKKPKHMSAD---------DLNDGFVLDKDDRRLLSYKDGKMNVEE 342
R + +D + VK H S +L DG K+++ + +D +++
Sbjct: 180 HH--RTMREDYSDKVKA-SHWSRSPPRPPRERFELGDGRKPVKEEK--MEERDLLSDLQ- 233
Query: 343 DVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQT 402
D+ + + K +S S+ E G S E+ EE + + E + E EEE E +E+ +T
Sbjct: 234 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEE---EEEEET 290
Query: 403 PGKGLISGKERAGKATRDEL 422
+ ++ A + + +E+
Sbjct: 291 GSNSEEASEQSAEEVSEEEM 310
Score = 38.1 bits (87), Expect = 0.035
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 26/234 (11%)
Query: 5 KKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALR 64
K+ RR S + G + K E + ++ Q R+ ++R + R
Sbjct: 70 KRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 129
Query: 65 KRTQT-LLKEYKERDKSNVFRDKRFGEYNSN-MSPEEKMMKRFALEQQRHHEKKSIYNLN 122
+R + L+ +ER++ + K E EE+ +R A + H + + +
Sbjct: 130 ERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 189
Query: 123 EDEELTHYGQS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTA 162
+ + +H+ +S L D K D++ D D R T SAE ++
Sbjct: 190 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 249
Query: 163 AHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
A G G ++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 250 AESGSGS----EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 299
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/428 (21%), Positives = 163/428 (38%), Gaps = 64/428 (14%)
Query: 163 AHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLD 222
+H GG H + +++ E E+ K +E ++ + +++KR R+ RE + ++L+
Sbjct: 113 SHSAEGGK--HARVKEKEREHERRKRHREEQDKARREWERQKR-REMAREHSRRERDRLE 169
Query: 223 QDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEE 282
Q ++ + + + E R++KE+ + RE E+ A + ++ K
Sbjct: 170 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 229
Query: 283 QEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV-- 340
R R LG D + VK+ K D L+D + +R+ S +
Sbjct: 230 HWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGS 288
Query: 341 --EEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKE 398
EE+ +EE+ +E S E E + E+ EE +S E + E E E E
Sbjct: 289 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 348
Query: 399 QRQTPGKGLI--------------SGKERAGKAT-----------------------RDE 421
+R+ L+ +E G+ T + E
Sbjct: 349 ERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 408
Query: 422 LPYTFAAPE---SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF- 476
LP A + S EE + L R E VV R + + + K+EK GF
Sbjct: 409 LPKYLPALQGCRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFP 466
Query: 477 --LLEYVGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIET 534
L + + P++ + ++VV S D I V+ H+++ ++ET
Sbjct: 467 ITSLREINTILKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMET 516
Query: 535 KGRAALPG 542
+ LPG
Sbjct: 517 MKQPFLPG 524
Score = 52.8 bits (125), Expect = 1e-06
Identities = 75/352 (21%), Positives = 143/352 (40%), Gaps = 35/352 (9%)
Query: 85 DKRFGEYNSNMSPEEKM-MKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDI 143
D+ E EEK +KR R ++ S+ E+ EL + +I N
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSL----EEGELRDHRM---EITIRNSP 66
Query: 144 VDSDSDAEDRGTLSAELTAA---HFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKS 200
+ EDRG L + H+K ++ E+R E + K
Sbjct: 67 YRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKE 126
Query: 201 KQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEK-PKPDAYDMMVRE 259
K+ + ER+ + E +K ++W+ + + RD+ E+ + + +RE
Sbjct: 127 KEREHERRKRHR---EEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 183
Query: 260 LGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSAD---- 315
E + Q + AE ++E+E R++ A R + +D + VK H S
Sbjct: 184 QQKEQREQKERERR--AEERRKEREARREVSAHH--RTMREDYSDKVKA-SHWSRSPPRP 238
Query: 316 -----DLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDT 370
+L DG K+++ + +D +++ D+ + + K +S S+ E G S E+
Sbjct: 239 PRERFELGDGRKPVKEEK--MEERDLLSDLQ-DISDSERKTSSAESSSAESGSGSEEEEE 295
Query: 371 EESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDEL 422
EE + + E + E EEE E +E+ +T + ++ A + + +E+
Sbjct: 296 EEEEEEEEGSTSEESEEEEEEEE---EEEEETGSNSEEASEQSAEEVSEEEM 344
Score = 38.1 bits (87), Expect = 0.035
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 26/234 (11%)
Query: 5 KKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALR 64
K+ RR S + G + K E + ++ Q R+ ++R + R
Sbjct: 104 KRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 163
Query: 65 KRTQT-LLKEYKERDKSNVFRDKRFGEYNSN-MSPEEKMMKRFALEQQRHHEKKSIYNLN 122
+R + L+ +ER++ + K E EE+ +R A + H + + +
Sbjct: 164 ERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 223
Query: 123 EDEELTHYGQS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTA 162
+ + +H+ +S L D K D++ D D R T SAE ++
Sbjct: 224 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 283
Query: 163 AHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
A G G ++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 284 AESGSGS----EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 333
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 57.8 bits (138), Expect = 4e-08
Identities = 80/366 (21%), Positives = 157/366 (42%), Gaps = 91/366 (24%)
Query: 48 TRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFAL 107
T+ ++ + + RA +++R ++ E+ K ++ ++ F E S ++ +EK + R
Sbjct: 2091 TQEEIKMTKMKRALFVKERRLSI-----EQSKLDI-KEWDFSEKRSELTKDEKKLAR--- 2141
Query: 108 EQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGG 167
+QR K +N++E++T LA KH++++ D E+ G + E
Sbjct: 2142 -KQRKLANKMRRMINKEEKMTEEESKLA--RKHSEVILDD---EEEGGIEEEEVIPFL-- 2193
Query: 168 GGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKE 227
+ + + RKE AK + +E+ + + D +E E + E
Sbjct: 2194 ---------------KRRWRKRKE------AKRGDKPKEKFSSQVDEVESEEHFSE---E 2229
Query: 228 IQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLR 287
+++LL D+ EK + L E + + + E E +EE+E R
Sbjct: 2230 MESLL----------DELEKQE---------SLSSEEEEEREEEEEREEEEVREEEEE-R 2269
Query: 288 KLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEE 347
K E E + + K+E+E KK K +++ + K V E+ +E
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE-----------------KEEVFEEKEEI 2312
Query: 348 QSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGL 407
S+E ++ S+EEE EES S + +D E + +E+ K +++R++
Sbjct: 2313 MSEEETESLSDEEE--------EEESCSLEEEVDREKEILKKEKQFKLQEQRRKS----- 2359
Query: 408 ISGKER 413
+ G+ER
Sbjct: 2360 LRGRER 2365
Score = 40.8 bits (94), Expect = 0.005
Identities = 101/441 (22%), Positives = 175/441 (39%), Gaps = 109/441 (24%)
Query: 33 EVKVNRQKFQILGRKTR-HDVGLPGVSRARALRKRTQTLLKEYKER--DKSNVFRDKRF- 88
E K+ ++K ++ +K + + V +L K+ + L +E + +K+ V KR
Sbjct: 1892 EEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
Query: 89 GEYNSNMSPEEKM----MKRFALEQQRHHEKKSIYNLNEDEE------LTHYGQSLADIE 138
GE + ++ EEK MKR A E+ R E K + E E +T Q L E
Sbjct: 1952 GELD--IAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL--FE 2007
Query: 139 KHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQ---EGEEREKPKSRKELIEE 195
+ + + EDR E A G L + Q+ +G+ + SRK
Sbjct: 2008 RKLSLEEKILLHEDRILAMEESEIAK----GKLEFTRGQRIFVQGQRKLAKASRK----- 2058
Query: 196 LIAKSKQEKRERQAQREDALELTEKLDQDWKEI------QTLLSHKTPKSENRDKKEKPK 249
+ K ++ + A+ L+ +KL +D +++ T + E R E+ K
Sbjct: 2059 -LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSK 2117
Query: 250 PDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDE----DEN 305
D ++E F K S K E +LA+++ RKL A ++RRM+ K+E +E+
Sbjct: 2118 LD-----IKEWDFSEKR--SELTKDEKKLARKQ----RKL-ANKMRRMINKEEKMTEEES 2165
Query: 306 VKKPKHMSA--DDLNDGFVLDKD-----DRRLLSYKDGK--------------------- 337
KH DD +G + +++ RR K+ K
Sbjct: 2166 KLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEH 2225
Query: 338 -----------------MNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHL 380
++ EE+ + E+ +E + E EEE + E+ E
Sbjct: 2226 FSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGE--------- 2276
Query: 381 DLESNVESEEENEKPAKEQRQ 401
E VE EEE +K K++++
Sbjct: 2277 --EKQVEKEEEEKKKKKKEKK 2295
Score = 31.2 bits (69), Expect = 4.3
Identities = 85/410 (20%), Positives = 160/410 (39%), Gaps = 47/410 (11%)
Query: 75 KERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSL 134
+E +K R K ++ EEK+ K+ + E K+I + EEL Q+L
Sbjct: 1653 QEAEKLAQKRKKLAKKWEKVAREEEKLAKKGG----KLAEVKNIL-AQKVEELPQREQNL 1707
Query: 135 ADIEKH--NDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKEL 192
EK ++ + + D E+ EL G L ++ ++ EE E ++E
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEE-----GKLVEEKKKLAEEEEALAWQREK 1762
Query: 193 IEELIAKSKQEKRERQAQREDALELTEKLDQDWKEI----QTLLSHKTPKSENRDK---- 244
+ E K QE+ ++E + EK+ ++ + + + L+ K ++ R++
Sbjct: 1763 LSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINS 1822
Query: 245 -KEKPKPDAYDMMVRELGFEMK--AQPSNRMKTEAE---LAKEEQEHLRK--LEAERLRR 296
+E K + L E K AQ ++ E KE H +K ++ +
Sbjct: 1823 MEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLG 1882
Query: 297 MLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPE 356
M K + +K + L + +++L+ +D +E + +E+ K A +
Sbjct: 1883 MFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKA 1942
Query: 357 SNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGK 416
+ + G D + + L+LE +EE+ L+ GKE K
Sbjct: 1943 MVQGKKRLRGELDIAKEEKA---LNLEMKRLAEEKMR-------------LVEGKETLSK 1986
Query: 417 ATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVE-RIQKCNHPSLAEG 465
E + +EL L S+EE++L+ E RI +A+G
Sbjct: 1987 GETPETSRQRKMTQVEQELFERKL--SLEEKILLHEDRILAMEESEIAKG 2034
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 57.8 bits (138), Expect = 4e-08
Identities = 88/418 (21%), Positives = 159/418 (38%), Gaps = 62/418 (14%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLL 232
H + +++ E E+ K +E ++ + +++KR R+ RE + ++L+Q ++ +
Sbjct: 110 HARVKEKEREHERRKRHREEQDKARREWERQKR-REMAREHSRRERDRLEQLERKRERER 168
Query: 233 SHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAE 292
+ + E R++KE+ + RE E+ A + ++ K
Sbjct: 169 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 228
Query: 293 RLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV----EEDVQEEQ 348
R R LG D + VK+ K D L+D + +R+ S + EE+ +EE+
Sbjct: 229 RERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 287
Query: 349 SKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLI 408
+E S E E + E+ EE +S E + E E E E+R+ L+
Sbjct: 288 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 347
Query: 409 --------------SGKERAGKAT-----------------------RDELPYTFAAPE- 430
+E G+ T + ELP A +
Sbjct: 348 VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQG 407
Query: 431 --SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF---LLEYVGDL 484
S EE + L R E VV R + + + K+EK GF L + +
Sbjct: 408 CRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI 465
Query: 485 ATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAALPG 542
P++ + ++VV S D I V+ H+++ ++ET + LPG
Sbjct: 466 LKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 513
Score = 53.5 bits (127), Expect = 8e-07
Identities = 74/349 (21%), Positives = 143/349 (40%), Gaps = 40/349 (11%)
Query: 85 DKRFGEYNSNMSPEEKM-MKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDI 143
D+ E EEK +KR R ++ S+ E+ EL + +I N
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSL----EEGELRDH---CMEITIRNSP 66
Query: 144 VDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQE 203
+ EDRG L + +++E K + RKE + + ++E
Sbjct: 67 YRREDSMEDRGEEDDSLAIKP-------PQQMSRKEKVHHRKDEKRKEKKHARVKEKERE 119
Query: 204 KRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEK-PKPDAYDMMVRELGF 262
R+ RE+ +K ++W+ + + RD+ E+ + + +RE
Sbjct: 120 HERRKRHREEQ----DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 175
Query: 263 EMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSAD------- 315
E + Q + AE ++E+E R++ A R + +D + VK H S
Sbjct: 176 EQREQKERERR--AEERRKEREARREVSAHH--RTMREDYSDKVKA-SHWSRSPPRPPRE 230
Query: 316 --DLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEES 373
+L DG K+++ + +D +++ D+ + + K +S S+ E G S E+ EE
Sbjct: 231 RFELGDGRKPVKEEK--MEERDLLSDLQ-DISDSERKTSSAESSSAESGSGSEEEEEEEE 287
Query: 374 DSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDEL 422
+ + E + E EEE E +E+ +T + ++ A + + +E+
Sbjct: 288 EEEEEGSTSEESEEEEEEEE---EEEEETGSNSEEASEQSAEEVSEEEM 333
Score = 35.8 bits (81), Expect = 0.17
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 28/165 (16%)
Query: 72 KEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYG 131
+E K R++ R+++ E + EE+ +R A + H + + ++ + +H+
Sbjct: 166 RERKMREQQKEQREQKERERRA----EERRKEREARREVSAHHRTMREDYSDKVKASHWS 221
Query: 132 QS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTAAHFGGGGGL 171
+S L D K D++ D D R T SAE ++A G G
Sbjct: 222 RSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-- 279
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 280 --EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 322
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 57.8 bits (138), Expect = 4e-08
Identities = 88/418 (21%), Positives = 159/418 (38%), Gaps = 62/418 (14%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLL 232
H + +++ E E+ K +E ++ + +++KR R+ RE + ++L+Q ++ +
Sbjct: 76 HARVKEKEREHERRKRHREEQDKARREWERQKR-REMAREHSRRERDRLEQLERKRERER 134
Query: 233 SHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAE 292
+ + E R++KE+ + RE E+ A + ++ K
Sbjct: 135 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 194
Query: 293 RLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV----EEDVQEEQ 348
R R LG D + VK+ K D L+D + +R+ S + EE+ +EE+
Sbjct: 195 RERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 253
Query: 349 SKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLI 408
+E S E E + E+ EE +S E + E E E E+R+ L+
Sbjct: 254 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 313
Query: 409 --------------SGKERAGKAT-----------------------RDELPYTFAAPE- 430
+E G+ T + ELP A +
Sbjct: 314 VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQG 373
Query: 431 --SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF---LLEYVGDL 484
S EE + L R E VV R + + + K+EK GF L + +
Sbjct: 374 CRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI 431
Query: 485 ATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAALPG 542
P++ + ++VV S D I V+ H+++ ++ET + LPG
Sbjct: 432 LKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 479
Score = 52.8 bits (125), Expect = 1e-06
Identities = 55/257 (21%), Positives = 114/257 (44%), Gaps = 25/257 (9%)
Query: 176 TQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHK 235
+++E K + RKE + + ++E R+ RE+ +K ++W+ + +
Sbjct: 58 SRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ----DKARREWERQKRREMAR 113
Query: 236 TPKSENRDKKEK-PKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERL 294
RD+ E+ + + +RE E + Q + AE ++E+E R++ A
Sbjct: 114 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR--AEERRKEREARREVSAHH- 170
Query: 295 RRMLGKDEDENVKKPKHMSAD---------DLNDGFVLDKDDRRLLSYKDGKMNVEEDVQ 345
R + +D + VK H S +L DG K+++ + +D +++ D+
Sbjct: 171 -RTMREDYSDKVKA-SHWSRSPPRPPRERFELGDGRKPVKEEK--MEERDLLSDLQ-DIS 225
Query: 346 EEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGK 405
+ + K +S S+ E G S E+ EE + + E + E EEE E +E+ +T
Sbjct: 226 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEE---EEEEETGSN 282
Query: 406 GLISGKERAGKATRDEL 422
+ ++ A + + +E+
Sbjct: 283 SEEASEQSAEEVSEEEM 299
Score = 35.8 bits (81), Expect = 0.17
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 28/165 (16%)
Query: 72 KEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYG 131
+E K R++ R+++ E + EE+ +R A + H + + ++ + +H+
Sbjct: 132 RERKMREQQKEQREQKERERRA----EERRKEREARREVSAHHRTMREDYSDKVKASHWS 187
Query: 132 QS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTAAHFGGGGGL 171
+S L D K D++ D D R T SAE ++A G G
Sbjct: 188 RSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-- 245
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 246 --EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 288
>gi|18093112 ABT1-associated protein [Homo sapiens]
Length = 851
Score = 57.8 bits (138), Expect = 4e-08
Identities = 86/367 (23%), Positives = 144/367 (39%), Gaps = 59/367 (16%)
Query: 82 VFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLA-DIEKH 140
V +D RF E + K+ KRF + H+KK N D+ S D+++
Sbjct: 16 VAKDPRFWEMPEK-DRKVKIDKRF---RAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRF 71
Query: 141 NDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKS 200
D+ DSDS+ LS E + A L KK +++ + +K K L+E K
Sbjct: 72 YDLSDSDSN------LSGEDSKA-------LSQKKIKKKKTQTKKEIDSKNLVE----KK 114
Query: 201 KQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVREL 260
K+ K+ E+ +L + K+++T K D PK D+ +E
Sbjct: 115 KETKKANHKGSENKTDLDNSIGI--KKMKTSCKFKI------DSNISPKKDS-----KEF 161
Query: 261 GFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLND- 319
+ K + N ++ + + EE++ R L E VK P+ + +
Sbjct: 162 TQKNKKEKKNIVQHTTDSSLEEKQ-----------RTLDSGTSEIVKSPRIECSKTRREM 210
Query: 320 ----GFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEE-------GDSSGGE 368
++ +D + DG+M ++D EE S+ S+ S+EE G +SG +
Sbjct: 211 QSVVQLIMTRDSDGYENSTDGEM-CDKDALEEDSESVSEIGSDEESENEITSVGRASGDD 269
Query: 369 DTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAA 428
D E D + + E E E+++K GKG I T D P
Sbjct: 270 DGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGF 329
Query: 429 PESYEEL 435
++ EL
Sbjct: 330 EHAWREL 336
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 56.6 bits (135), Expect = 1e-07
Identities = 83/368 (22%), Positives = 146/368 (39%), Gaps = 58/368 (15%)
Query: 110 QRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGG 169
+RHH+++ G+ L I+ + + AE R L ++T+A
Sbjct: 231 RRHHQEE-------------VGELLGQIQG-SGAAQAQMQAETRDALKCDVTSA------ 270
Query: 170 GLLHKKTQQEGEEREKPKSRKEL----IEELIAKSKQEKRERQAQREDALELTEKLDQDW 225
L + Q EG + +E ++ L +K ++ +E+ E +L
Sbjct: 271 -LREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQART 329
Query: 226 KEIQTLLSHKTPKSENRDKKE----------KPKPDAYDMMVRELGFEMKAQP---SNRM 272
E++ L S K R + E + D +R +EM AQ + +
Sbjct: 330 TELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
Query: 273 KTEAELAKEEQEHLRKLEAERLRRMLGK---DEDENVKK----PKHMSADDLNDGFVLDK 325
+ L E + + LE E R G E + K H+ V++K
Sbjct: 390 NVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEK 449
Query: 326 DDRR--LLSYKDGKMNVEEDVQEEQSKEASDPESNEEEG----DSSGGEDTEESDSPDSH 379
++ ++ + + V E+V EE+ KEA + E EEEG ++ GGE EE+ SP +
Sbjct: 450 SEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE--EETKSPPA- 506
Query: 380 LDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLL 439
E E+E + P KE+ ++P + KE A + P +P + EE +S
Sbjct: 507 ---EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPP 562
Query: 440 LGRSMEEQ 447
+S E++
Sbjct: 563 EAKSPEKE 570
Score = 41.6 bits (96), Expect = 0.003
Identities = 49/241 (20%), Positives = 105/241 (43%), Gaps = 16/241 (6%)
Query: 175 KTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQ---REDALELTEKLDQDWKEIQTL 231
K+ + E + K++ L E+ A K+ ++ + + +E+ K+ + K+ +
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 232 LSHKTPKSENRD---KKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRK 288
+ TPK+E + K+E PK +A V E +P +++ E KEE E +K
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPK---ESKVEAKKEEAEDKKK 902
Query: 289 L---EAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQ 345
+ E E ++ K ED K+ ++ + +D K+ + K+ ++D +
Sbjct: 903 VPTPEKEAPAKVEVK-EDAKPKEKTEVAKKEPDDAKA--KEPSKPAEKKEAAPE-KKDTK 958
Query: 346 EEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGK 405
EE++K+ + E + ++E P + +S+ +++++ P K K
Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Query: 406 G 406
G
Sbjct: 1019 G 1019
Score = 41.2 bits (95), Expect = 0.004
Identities = 61/330 (18%), Positives = 132/330 (40%), Gaps = 29/330 (8%)
Query: 99 EKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSA 158
EK K + +++ E + + E+EE + + E+ + +++ E+ + A
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE-EEGGEEEEAEGGEEETKSPPA 506
Query: 159 ELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKS----KQEKRERQAQREDA 214
E A+ K+ + +E K + + E+ AKS K ++ + +E+A
Sbjct: 507 EEAASP--------EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 215 LELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKT 274
E + +E ++ K+P+ KE+ K A + +K + + +
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 275 EAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYK 334
++ + KEE + ++++ + K+E ++ +K K ++ K + S
Sbjct: 619 KSPV-KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA-------KSPEKAKSPV 670
Query: 335 DGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPD-SHLDLESNVESEEENE 393
+ E + EA PE + EE+ SP+ + ++ +S E+ +
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVK-------EEAKSPEKAKSPVKEEAKSPEKAK 723
Query: 394 KPAKEQRQTPGKGLISGKERAGKATRDELP 423
P KE+ +TP K KE A + + P
Sbjct: 724 SPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Score = 37.7 bits (86), Expect = 0.046
Identities = 48/265 (18%), Positives = 99/265 (37%), Gaps = 44/265 (16%)
Query: 173 HKKTQQEGEEREKPKSRKE--LIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQT 230
H K + E + + KS KE ++EE +++ + + + ++A E K ++ +E +
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 231 LLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLE 290
+ KS ++ P+ +A K+ K+ AE E+E +
Sbjct: 495 EGGEEETKSPPAEEAASPEKEA------------KSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 291 AERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSK 350
+ E K P + + + + E +S
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEA---------------------KSPAEVKSP 581
Query: 351 EASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISG 410
E + + EE + + E++ SP ++ +S E + P KE+ ++P + +
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSP-----VKEEAKSPAEAKSPVKEEAKSPAE--VKS 634
Query: 411 KERAGKATRDEL--PYTFAAPESYE 433
E+A T++E P +PE E
Sbjct: 635 PEKAKSPTKEEAKSPEKAKSPEKEE 659
Score = 30.8 bits (68), Expect = 5.6
Identities = 40/202 (19%), Positives = 83/202 (41%), Gaps = 13/202 (6%)
Query: 221 LDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAK 280
L + +I ++ +H KSE + K + K + ++V E E Q + + E E
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVE-KSEKETVIVEEQTEE--TQVTEEVTEEEEKEA 478
Query: 281 EEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV 340
+E+E + E G++E ++ + S + V ++ + K
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 341 EEDVQEEQSKEASDPESNEEEGDSSG-GEDTEESDSPDSHLDLESNVESEEENEKPAKEQ 399
+ + + ++A P E + + EE+ SP + V+S E+ + PAKE+
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP-------AEVKSPEKAKSPAKEE 591
Query: 400 RQTPGKGLISGKERAGKATRDE 421
++P + E+A ++E
Sbjct: 592 AKSPAEA--KSPEKAKSPVKEE 611
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 56.6 bits (135), Expect = 1e-07
Identities = 85/423 (20%), Positives = 169/423 (39%), Gaps = 28/423 (6%)
Query: 3 KAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRARA 62
KAK VG +A P G G + S+ E + ++ + K R ++ PG
Sbjct: 640 KAKSVG---EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKEL 696
Query: 63 LRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLN 122
K +E+K+RD + +R + + E M+ E+ E++ +
Sbjct: 697 AEK------EEWKKRDGEEQEQKEREQGHQKERNQE---MEEGGEEEHGEGEEEE-GDRE 746
Query: 123 EDEELTHYGQSLAD---IEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQE 179
E+EE G+ + +E + + + E+R E G G ++T+
Sbjct: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA--GKEEKGEEEGDQGEGEEEETEGR 804
Query: 180 GEEREKP-KSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPK 238
GEE+E+ + +EE + ++E+ E + + E+ E+ + + +E + + +
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 239 SENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRML 298
E ++ E+ + + + G E + E E +E + + E E
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE------ 918
Query: 299 GKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESN 358
GK E+E + + +G +D ++G+ EE+ E + +E + E
Sbjct: 919 GKGEEEGEEGE---GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE 975
Query: 359 EEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKAT 418
E EG+ E E + + + E E EEE E +E+ + +G + G+E G+
Sbjct: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
Query: 419 RDE 421
+E
Sbjct: 1036 EEE 1038
Score = 37.7 bits (86), Expect = 0.046
Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 10/90 (11%)
Query: 335 DGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESE----- 389
+G+ E +V+ E E + E EEEG+ G E +E + ++ + E E E
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
Query: 390 ---EENEKPAKEQRQTPGKGLISGKERAGK 416
EENE+ E+ + K I G + GK
Sbjct: 1072 TGEEENERQDGEEYKKVSK--IKGSVKYGK 1099
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 56.2 bits (134), Expect = 1e-07
Identities = 61/310 (19%), Positives = 126/310 (40%), Gaps = 53/310 (17%)
Query: 174 KKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLS 233
K+ ++E E R K + KEL+ + + K ++EKR R ++E+ +L E+ Q ++ + +L
Sbjct: 833 KQDEEERELRAKQEQEKELLRQKLLKEQEEKRLR--EKEEQKKLLEQRAQYVEKTKNILM 890
Query: 234 HKTPKSENRDKK-------EKPKPDAYDMMVR---ELGFEMKAQPSNRMKTEAELAKEEQ 283
++KK K +D V + + + R + +E E++
Sbjct: 891 FTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDE 950
Query: 284 EHLRKLEAERLRRMLGK-----DEDENVKKPK--------------------HMSADDLN 318
E + + +R R G+ DE EN KPK M +
Sbjct: 951 EGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKS 1010
Query: 319 DGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEE-------EGDSSGGEDTE 371
+ DD S + K+ + ++ S SD + +E+ E DS ++
Sbjct: 1011 KAIISSSDD----SSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKS 1066
Query: 372 ESDSPDSHLDLESNVESEEENEKPAKEQR-----QTPGKGLISGKERAGKATRDELPYTF 426
S++ + + ++++P++++R Q+ + + SG+ +G + D P +
Sbjct: 1067 GSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASP 1126
Query: 427 AAPESYEELR 436
+A +E R
Sbjct: 1127 SAESDHESER 1136
Score = 37.4 bits (85), Expect = 0.060
Identities = 75/378 (19%), Positives = 135/378 (35%), Gaps = 61/378 (16%)
Query: 60 ARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEK-KSI 118
ARA ++ + K+ + + R K E E++ K+ ++ ++ EK K+I
Sbjct: 829 ARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNI 888
Query: 119 YNLNEDEELTHY-------GQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGL 171
+ E T G+ + ++ V+ D+D D +S + G G
Sbjct: 889 LMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTD--DDLPISKKKKRRK---GSGS 943
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTL 231
+ +EG ER+K +KR R + E+ + D + +
Sbjct: 944 EQEGEDEEGGERKK-----------------KKRRRHPKGEEGSD-----DDETENGPKP 981
Query: 232 LSHKTPKSENRDKKEKPKPDAY-DMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLE 290
+ PK+E KK+ PKP+ M ++ + S+ E +L ++ H R
Sbjct: 982 KKRRPPKAE---KKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSN 1038
Query: 291 AERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSK 350
+ D DE+ ++ K S++ D D+ + S + Q
Sbjct: 1039 S-------NSDSDEDEQRKKCASSES-------DSDENQNKSGSEAGSPRRPRRQRSDQD 1084
Query: 351 EASDPESNEEEGDSSGGEDTEESDSPDSHLDLESN--------VESEEENEKPAKEQRQT 402
SD S + S D E S SH + N ES+ E+E+ + +
Sbjct: 1085 SDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSG 1144
Query: 403 PGKGLISGKERAGKATRD 420
G G S E + D
Sbjct: 1145 QGSGNESEPEGSNNEASD 1162
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/246 (22%), Positives = 103/246 (41%), Gaps = 29/246 (11%)
Query: 185 KPKSRKELIEE-------LIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTP 237
K K++ +++EE +A++KQE + E+A K+ + + ++ K
Sbjct: 44 KMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEE 103
Query: 238 KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRM 297
E+ +K K +A V+ + K ++ + + E KE+++ + + + +
Sbjct: 104 NIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNG 163
Query: 298 LGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPES 357
K ED K+ D +G +DGK E++ +EE KE D +
Sbjct: 164 NEKGEDAKEKEDGKKGEDGKGNG-------------EDGKEKGEDEKEEEDRKETGDGKE 210
Query: 358 NE---EEGDSSGGEDT----EESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISG 410
NE E+GD G+D +E + D D N E + ++ KE+ + GK
Sbjct: 211 NEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEE--GKEEDEI 268
Query: 411 KERAGK 416
KE GK
Sbjct: 269 KEDDGK 274
Score = 35.0 bits (79), Expect = 0.30
Identities = 63/261 (24%), Positives = 106/261 (40%), Gaps = 39/261 (14%)
Query: 124 DEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEER 183
+E + Q++A+ K +V+ D + E+ A++T A ++ K + +
Sbjct: 53 EENIDTSAQAVAET-KQEAVVEEDYN-ENAKNGEAKITEAP-ASEKEIVEVKEENIEDAT 109
Query: 184 EKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRD 243
EK +KE A + + K E + Q+ED + E+ + KE D
Sbjct: 110 EKGGEKKE------AVAAEVKNEEEDQKEDEEDQNEEKGEAGKE---------------D 148
Query: 244 KKEKPKPDA-YDMMVRELGFEMKAQPSNRM----KTEAELAKEEQEHLRKLEAERLRRML 298
K EK + D D E G + K + + K E KE+ E K E +R
Sbjct: 149 KDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGED-EKEEEDRKETGD 207
Query: 299 GKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESN 358
GK+ ++ +K D V K+D + +DGK + E +EE KE D +
Sbjct: 208 GKENEDGKEKGDKKEGKD-----VKVKEDEK--EREDGKED-EGGNEEEAGKEKEDLKEE 259
Query: 359 EE-EGDSSGGEDTEESDSPDS 378
EE + + ED + + P S
Sbjct: 260 EEGKEEDEIKEDDGKKEEPQS 280
Score = 31.2 bits (69), Expect = 4.3
Identities = 34/162 (20%), Positives = 72/162 (44%), Gaps = 2/162 (1%)
Query: 106 ALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHF 165
A E + E + +++EE G+ D EK + D + ++G + E
Sbjct: 120 AAEVKNEEEDQKEDEEDQNEEKGEAGKEDKD-EKGEEDGKEDKNGNEKGEDAKEKEDGKK 178
Query: 166 GGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDW 225
G G + +++GE+ ++ + RKE + + +EK +++ ++ ++ EK +D
Sbjct: 179 GEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDG 238
Query: 226 KEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQ 267
KE + + K E D KE+ + D + + G + + Q
Sbjct: 239 KEDEGGNEEEAGK-EKEDLKEEEEGKEEDEIKEDDGKKEEPQ 279
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/370 (20%), Positives = 148/370 (40%), Gaps = 61/370 (16%)
Query: 57 VSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKK 116
+S+ R K+ + K KE+++ + +++R E E+ +R E++R E++
Sbjct: 281 ISKFRDTHKKLEEE-KGKKEKERQEIEKERRERE-------RERERERERRERERERERE 332
Query: 117 SIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAE-DRGTLSAELTAAHFGGGGGLLHKK 175
++ E D K D D D E DR +
Sbjct: 333 REREKEKERERERERDRDRDRTKERD---RDRDRERDRD--------------------R 369
Query: 176 TQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHK 235
++ +R K +SR KS+ +RER+ +RE E + +++ + + +
Sbjct: 370 DRERSSDRNKDRSRSR------EKSRDRERERERERERERERERERERERERERERERER 423
Query: 236 TPKSENRDKKEKPKPDAYDMMVRELGF-EMKAQPSNRMKT--------------EAELAK 280
+ + + +E+ + DAY+ E E +A R+K EAE +
Sbjct: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
Query: 281 EEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV 340
E + + K EA+RL+ L +D D++ PK+ L + D++ +D K
Sbjct: 484 ERRREMAK-EAKRLKEFL-EDYDDDRDDPKYYRGSALQKR-LRDREKEMEADERDRKREK 540
Query: 341 E--EDVQEEQSKEA---SDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKP 395
E E++++ E D E E ++ + P+S + E E EE+ E+P
Sbjct: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600
Query: 396 AKEQRQTPGK 405
+E+ + K
Sbjct: 601 MEEEEEPEQK 610
Score = 43.5 bits (101), Expect = 8e-04
Identities = 62/300 (20%), Positives = 117/300 (39%), Gaps = 36/300 (12%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLL 232
HKK ++E ++EK + E +E+RER+ +RE E E+ + +E +
Sbjct: 288 HKKLEEEKGKKEKERQEIE----------KERRERERERERERERREREREREREREREK 337
Query: 233 SHKTPKSENRDK-----KEKPKP---------DAYDMMVRELGFEMKAQPSNRMKTEAEL 278
+ + RD+ KE+ + D R + S + E E
Sbjct: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERER 397
Query: 279 AKE-EQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGK 337
+E E+E R+ E ER R + E E K K +D D + K +R+L +
Sbjct: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAY 457
Query: 338 MNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHL-DLESNVESEEENEKPA 396
++ + + K+ + E E + E +E+ L D + + + + A
Sbjct: 458 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517
Query: 397 KEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQK 456
++R + + ER K ++EL EE+R LL + ++R+++
Sbjct: 518 LQKRLRDREKEMEADERDRKREKEEL----------EEIRQRLLAEGHPDPDAELQRMEQ 567
Score = 31.6 bits (70), Expect = 3.3
Identities = 41/217 (18%), Positives = 94/217 (43%), Gaps = 26/217 (11%)
Query: 190 KELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPK 249
K+L+ ++ AK+K + E +A+++ A + + + + L +T + + K
Sbjct: 155 KKLLVKVDAKTKAQLDEWKAKKK-ASNGNARPETVTNDDEEALDEETKRRDQMIK----- 208
Query: 250 PDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKP 309
A ++++RE E+ A ++E H RK + E+ + + +
Sbjct: 209 -GAIEVLIREYSSELNAP-----------SQESDSHPRKKKKEKKEDIFRRFPVAPLIPY 256
Query: 310 KHMSADDLNDGFVLDKDDRRLLS-----YKDGKMNVEEDV-QEEQSKEASDPESNEEEGD 363
++ +D+N +++D R L+S ++D +EE+ ++E+ ++ + E E E +
Sbjct: 257 PLITKEDIN-AIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERE 315
Query: 364 SSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQR 400
+ E + + + E E E E E+ R
Sbjct: 316 RERERERRERER-EREREREREKEKERERERERDRDR 351
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 55.5 bits (132), Expect = 2e-07
Identities = 89/427 (20%), Positives = 159/427 (37%), Gaps = 64/427 (14%)
Query: 164 HFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQ 223
H G H + ++ ER K + R+E ++ + + ++ R+ RE + ++L+Q
Sbjct: 112 HSHSAEGGKHARVKEREHERRK-RHREE--QDKARREWERQKRREMAREHSRRERDRLEQ 168
Query: 224 DWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQ 283
++ + + + E R++KE+ + RE E+ A + ++ K
Sbjct: 169 LERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASH 228
Query: 284 EHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV--- 340
R R LG D + VK+ K D L+D + +R+ S +
Sbjct: 229 WSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG 287
Query: 341 -EEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQ 399
EE+ +EE+ +E S E E + E+ EE +S E + E E E E+
Sbjct: 288 SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 347
Query: 400 RQTPGKGLI--------------SGKERAGKAT-----------------------RDEL 422
R+ L+ +E G+ T + EL
Sbjct: 348 RENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQEL 407
Query: 423 PYTFAAPE---SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF-- 476
P A + S EE + L R E VV R + + + K+EK GF
Sbjct: 408 PKYLPALQGCRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 465
Query: 477 -LLEYVGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETK 535
L + + P++ + ++VV S D I V+ H+++ ++ET
Sbjct: 466 TSLREINTILKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMETM 515
Query: 536 GRAALPG 542
+ LPG
Sbjct: 516 KQPFLPG 522
Score = 50.4 bits (119), Expect = 7e-06
Identities = 55/259 (21%), Positives = 110/259 (42%), Gaps = 21/259 (8%)
Query: 174 KKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLS 233
+K +E+ K K R K + K +R+ E +K ++W+ +
Sbjct: 95 EKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREM 154
Query: 234 HKTPKSENRDKKEK-PKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAE 292
+ RD+ E+ + + +RE E + Q + AE ++E+E R++ A
Sbjct: 155 AREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR--AEERRKEREARREVSAH 212
Query: 293 RLRRMLGKDEDENVKKPKHMSAD---------DLNDGFVLDKDDRRLLSYKDGKMNVEED 343
R + +D + VK H S +L DG K+++ + +D +++ D
Sbjct: 213 H--RTMREDYSDKVKA-SHWSRSPPRPPRERFELGDGRKPVKEEK--MEERDLLSDLQ-D 266
Query: 344 VQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTP 403
+ + + K +S S+ E G S E+ EE + + E + E EEE E +E+ +T
Sbjct: 267 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEE---EEEEETG 323
Query: 404 GKGLISGKERAGKATRDEL 422
+ ++ A + + +E+
Sbjct: 324 SNSEEASEQSAEEVSEEEM 342
Score = 35.8 bits (81), Expect = 0.17
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 28/165 (16%)
Query: 72 KEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYG 131
+E K R++ R+++ E + EE+ +R A + H + + ++ + +H+
Sbjct: 175 RERKMREQQKEQREQKERERRA----EERRKEREARREVSAHHRTMREDYSDKVKASHWS 230
Query: 132 QS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTAAHFGGGGGL 171
+S L D K D++ D D R T SAE ++A G G
Sbjct: 231 RSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-- 288
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 289 --EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 331
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 55.5 bits (132), Expect = 2e-07
Identities = 69/276 (25%), Positives = 123/276 (44%), Gaps = 46/276 (16%)
Query: 178 QEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTP 237
QE EE +PK L EE ++E+ E QA+ E+A E E + S + P
Sbjct: 1205 QESEETVEPKEDMPLPEE-----RKEEEEMQAEAEEAEEGEE---------EDAASSEVP 1250
Query: 238 KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRM 297
+ D P+ + + V E + R+ E ++EEQ+ L + E E
Sbjct: 1251 AASPADSSNSPETETKEPEVEE------EEEKPRVSEEQRQSEEEQQELEEPEPE----- 1299
Query: 298 LGKDED---ENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQS-KEAS 353
++ED E + H ADD +DG L+ ++ L + + +V+E+ ++S +A+
Sbjct: 1300 --EEEDAAAETAQNDDH-DADDEDDGH-LESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355
Query: 354 DPESNEEEGDSSGGE--DTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGK 411
+S E+ D E EE S D+ + E SE+++E+ + + + LI K
Sbjct: 1356 MQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE-----LIELK 1410
Query: 412 ERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQ 447
E +E+P++ E+ + ++SL S E +
Sbjct: 1411 E------EEEIPHSELDLETVQAVQSLTQEESSEHE 1440
Score = 35.4 bits (80), Expect = 0.23
Identities = 44/225 (19%), Positives = 93/225 (41%), Gaps = 16/225 (7%)
Query: 149 DAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG--EEREKPKSRKELIEELIAKSKQEKRE 206
+ E+ S+E+ AA +T++ EE EKP+ +E + + + E+ E
Sbjct: 1238 EGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPE 1297
Query: 207 RQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKA 266
+ + + A E + D D + E+ KKE + + + E G +
Sbjct: 1298 PEEEEDAAAETAQNDDHDADD------EDDGHLESTKKKELEEQPTREDVKEEPGVQESF 1351
Query: 267 QPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKD 326
+N K+ ++ +E+ L E + D +V + ++D ++ K+
Sbjct: 1352 LDANMQKSREKIKDKEETELDSEEEQ-------PSHDTSVVSEQMAGSEDDHEEDSHTKE 1404
Query: 327 DRRLLSYKDGKMNVEEDVQEEQSKEA-SDPESNEEEGDSSGGEDT 370
+ L ++ + E D++ Q+ ++ + ES+E EG E+T
Sbjct: 1405 ELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEET 1449
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 55.5 bits (132), Expect = 2e-07
Identities = 69/276 (25%), Positives = 123/276 (44%), Gaps = 46/276 (16%)
Query: 178 QEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTP 237
QE EE +PK L EE ++E+ E QA+ E+A E E + S + P
Sbjct: 1205 QESEETVEPKEDMPLPEE-----RKEEEEMQAEAEEAEEGEE---------EDAASSEVP 1250
Query: 238 KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRM 297
+ D P+ + + V E + R+ E ++EEQ+ L + E E
Sbjct: 1251 AASPADSSNSPETETKEPEVEE------EEEKPRVSEEQRQSEEEQQELEEPEPE----- 1299
Query: 298 LGKDED---ENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQS-KEAS 353
++ED E + H ADD +DG L+ ++ L + + +V+E+ ++S +A+
Sbjct: 1300 --EEEDAAAETAQNDDH-DADDEDDGH-LESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355
Query: 354 DPESNEEEGDSSGGE--DTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGK 411
+S E+ D E EE S D+ + E SE+++E+ + + + LI K
Sbjct: 1356 MQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE-----LIELK 1410
Query: 412 ERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQ 447
E +E+P++ E+ + ++SL S E +
Sbjct: 1411 E------EEEIPHSELDLETVQAVQSLTQEESSEHE 1440
Score = 35.4 bits (80), Expect = 0.23
Identities = 44/225 (19%), Positives = 93/225 (41%), Gaps = 16/225 (7%)
Query: 149 DAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG--EEREKPKSRKELIEELIAKSKQEKRE 206
+ E+ S+E+ AA +T++ EE EKP+ +E + + + E+ E
Sbjct: 1238 EGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPE 1297
Query: 207 RQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKA 266
+ + + A E + D D + E+ KKE + + + E G +
Sbjct: 1298 PEEEEDAAAETAQNDDHDADD------EDDGHLESTKKKELEEQPTREDVKEEPGVQESF 1351
Query: 267 QPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKD 326
+N K+ ++ +E+ L E + D +V + ++D ++ K+
Sbjct: 1352 LDANMQKSREKIKDKEETELDSEEEQ-------PSHDTSVVSEQMAGSEDDHEEDSHTKE 1404
Query: 327 DRRLLSYKDGKMNVEEDVQEEQSKEA-SDPESNEEEGDSSGGEDT 370
+ L ++ + E D++ Q+ ++ + ES+E EG E+T
Sbjct: 1405 ELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEET 1449
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 55.5 bits (132), Expect = 2e-07
Identities = 69/276 (25%), Positives = 123/276 (44%), Gaps = 46/276 (16%)
Query: 178 QEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTP 237
QE EE +PK L EE ++E+ E QA+ E+A E E + S + P
Sbjct: 1205 QESEETVEPKEDMPLPEE-----RKEEEEMQAEAEEAEEGEE---------EDAASSEVP 1250
Query: 238 KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRM 297
+ D P+ + + V E + R+ E ++EEQ+ L + E E
Sbjct: 1251 AASPADSSNSPETETKEPEVEE------EEEKPRVSEEQRQSEEEQQELEEPEPE----- 1299
Query: 298 LGKDED---ENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQS-KEAS 353
++ED E + H ADD +DG L+ ++ L + + +V+E+ ++S +A+
Sbjct: 1300 --EEEDAAAETAQNDDH-DADDEDDGH-LESTKKKELEEQPTREDVKEEPGVQESFLDAN 1355
Query: 354 DPESNEEEGDSSGGE--DTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGK 411
+S E+ D E EE S D+ + E SE+++E+ + + + LI K
Sbjct: 1356 MQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE-----LIELK 1410
Query: 412 ERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQ 447
E +E+P++ E+ + ++SL S E +
Sbjct: 1411 E------EEEIPHSELDLETVQAVQSLTQEESSEHE 1440
Score = 35.4 bits (80), Expect = 0.23
Identities = 44/225 (19%), Positives = 93/225 (41%), Gaps = 16/225 (7%)
Query: 149 DAEDRGTLSAELTAAHFGGGGGLLHKKTQQEG--EEREKPKSRKELIEELIAKSKQEKRE 206
+ E+ S+E+ AA +T++ EE EKP+ +E + + + E+ E
Sbjct: 1238 EGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPE 1297
Query: 207 RQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKA 266
+ + + A E + D D + E+ KKE + + + E G +
Sbjct: 1298 PEEEEDAAAETAQNDDHDADD------EDDGHLESTKKKELEEQPTREDVKEEPGVQESF 1351
Query: 267 QPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKD 326
+N K+ ++ +E+ L E + D +V + ++D ++ K+
Sbjct: 1352 LDANMQKSREKIKDKEETELDSEEEQ-------PSHDTSVVSEQMAGSEDDHEEDSHTKE 1404
Query: 327 DRRLLSYKDGKMNVEEDVQEEQSKEA-SDPESNEEEGDSSGGEDT 370
+ L ++ + E D++ Q+ ++ + ES+E EG E+T
Sbjct: 1405 ELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEET 1449
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 55.5 bits (132), Expect = 2e-07
Identities = 95/465 (20%), Positives = 193/465 (41%), Gaps = 48/465 (10%)
Query: 18 AGARGGPAKANSNPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKER 77
AG+ G +A ++ EVK +L +K++ + + + R L + Q +KE +ER
Sbjct: 593 AGSAQGNNQACNSTSEVK------DLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERER 646
Query: 78 DKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNL-----NEDEELTHYGQ 132
++N+ ++ ++N + + +R LE+ +K++ L ++ T
Sbjct: 647 MRANL--EELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKMEREQHQTEIRD 702
Query: 133 SLADIEKHNDIVDSDSDAEDR--GTLSAELTAAHFGGGGGLLHKKTQQE---GEEREKPK 187
+ + +D +DS +EDR G L EL A L+ K+ Q++ ERE
Sbjct: 703 LQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 188 SRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENR----- 242
+ L EE+ + ++ + ++ + L E +++ K ++ L S +++
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 243 --------DKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERL 294
++K + + + + V +L +++ + K + L K E E +R+LE +
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE-IRQLEEALV 881
Query: 295 RRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASD 354
+ E + ++ + +++ LS K EE Q+EQ + +
Sbjct: 882 HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEK----LKEESEQKEQLRRLKN 937
Query: 355 PESNE--EEGDSSGGEDTEESD----SPDSHLDLESNVE--SEEENEKPAKEQRQTPGKG 406
NE G + E +D S S L+L++ ++ E+ + A+ QRQ K
Sbjct: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 407 LISGKER-AGKATRDELPYTFAAPESYEELR-SLLLGRSMEEQLL 449
L + K R +DE+ Y+ + L R + EQ L
Sbjct: 998 LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTL 1042
Score = 37.4 bits (85), Expect = 0.060
Identities = 77/368 (20%), Positives = 151/368 (41%), Gaps = 55/368 (14%)
Query: 76 ERDKSNV-FRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSL 134
E+D++ R K E N + + ++R + QR E E L Y +
Sbjct: 814 EQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI 873
Query: 135 ADIEKHNDIVDSDSDAED----RGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRK 190
+E+ +V + + ++ R L EL AA G L + TQ++ + EK K
Sbjct: 874 RQLEEA--LVHARKEEKEAVSARRALENELEAAQ-----GNLSQTTQEQKQLSEKLKEES 926
Query: 191 ELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENR--DKKEKP 248
E E+L ++ K E + +R + EKL ++ +I T + +N+ + KEK
Sbjct: 927 EQKEQL----RRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKN 982
Query: 249 KPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDE----DE 304
+ REL AE+ ++ +E + E RL M +DE +E
Sbjct: 983 R--------REL---------------AEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 305 NVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEED----VQEEQSKEASDPESNEE 360
++ + + L +L++ + L + K ++++D V++ + K + EE
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
Query: 361 EGDSSG------GEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERA 414
E ++S E+ + + L E + E +K + E++ K I E +
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGS 1139
Query: 415 GKATRDEL 422
+++++ L
Sbjct: 1140 YRSSKEGL 1147
Score = 32.3 bits (72), Expect = 1.9
Identities = 65/298 (21%), Positives = 121/298 (40%), Gaps = 64/298 (21%)
Query: 57 VSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKK 116
V +R Q L EYKE+++ + +R + + + + ++ ++ R E++
Sbjct: 961 VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE 1020
Query: 117 -SIYNLNEDEELTH---YGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLL 172
Y +DE LT Q+L D+E + D DR L ++
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD--DRSRLVKQM------------ 1066
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSK-----------QEKRERQAQREDALELTEKL 221
K Q E E+ ++ +L+ E I++S+ QE+ RQ D + L E+
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL-ERQ 1125
Query: 222 DQDWKE--IQTLLSHKTPK-----------SENRDKKEKPKPDAYDMM---------VRE 259
++D K I S+++ K +E D+ E + D ++ V+E
Sbjct: 1126 NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKE 1185
Query: 260 LGFEM----------KAQPSNRMKTEAELAKEEQEHLRKLEA--ERLRRMLGKDEDEN 305
L ++ K Q S R+K +E +E + +LE+ ++L+R L + D N
Sbjct: 1186 LVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMN 1243
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 55.1 bits (131), Expect = 3e-07
Identities = 64/337 (18%), Positives = 135/337 (40%), Gaps = 24/337 (7%)
Query: 75 KERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSL 134
KER++ R+KR E ++ E + K ++ RH E++ E E T +
Sbjct: 60 KERERR---REKRQTERETDRKRERRREKDRHRKRDRHRERQRDRE-KERERQTDRERDR 115
Query: 135 ADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGE---------EREK 185
++ N + + + E G + G ++ Q++ E ER++
Sbjct: 116 QREKERNRQKERERETEREGERGRDRQT------DGQRERERQRDAEKERERQTDRERQR 169
Query: 186 PKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKK 245
R E K++QE+RER+ QRE + ++ + +E + +T R ++
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERER--ERETETETERKRQ 227
Query: 246 EKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDEN 305
+ D RE + + + ++ +TE + +E+E R + +R RR ++ +
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERD---KERERERDRDRDRDRRQKERERQTD 284
Query: 306 VKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSS 365
K+ + D + + +R ++ K E + + E+ ++ E+E +
Sbjct: 285 RKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERK 344
Query: 366 GGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQT 402
TE + E ++E E E+ + RQ+
Sbjct: 345 RKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381
Score = 50.4 bits (119), Expect = 7e-06
Identities = 83/389 (21%), Positives = 149/389 (38%), Gaps = 64/389 (16%)
Query: 33 EVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYN 92
E + NRQK + R+T + G G R ++ + KER++ +R E N
Sbjct: 118 EKERNRQKER--ERETERE-GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERN 174
Query: 93 SNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAED 152
E + ++ E++R EK+ N ED + + + E+ + ++++ E
Sbjct: 175 RQKEREREKNRQERRERERQREKE---NKTEDR----HSERGRERERERE---TETETER 224
Query: 153 RGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQRE 212
+ E +KT++E REK R+ ++ + + ER +RE
Sbjct: 225 KRQTDRERDR----------QRKTERE---REKQAERE--------RASERETERDKERE 263
Query: 213 DALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRM 272
+ D+ KE + K + RD++ + K + RE + NR
Sbjct: 264 RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE-------RERNR- 315
Query: 273 KTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLS 332
K E+E R+ E ER R E E +K K + D +R +
Sbjct: 316 -------KRERERERERERERQRETERDREKERERKRKRQTEMD---------RERNRQT 359
Query: 333 YKDGKMNVEEDVQEEQSKE-ASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE 391
++G+ E + + E+ ++ S E E E D E + D + E + E
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRE 419
Query: 392 NEKPAKEQRQTPGKGLISGKERAGKATRD 420
EK + +R G G+ER + R+
Sbjct: 420 REKDRESER-----GRERGREREKQKGRE 443
Score = 38.9 bits (89), Expect = 0.021
Identities = 43/238 (18%), Positives = 89/238 (37%), Gaps = 21/238 (8%)
Query: 176 TQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHK 235
+Q+ R ++ K+ + +++Q++RER+ ++ T++ + +E
Sbjct: 33 SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRD 92
Query: 236 TPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAE---------LAKEEQEHL 286
+ RD++++ + R+ E Q +TE E + E+E
Sbjct: 93 RHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQ 152
Query: 287 RKLEAERLR---RMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEED 343
R E ER R R + + N +K + ++ +RR + K N ED
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREK---------NRQERRERERQREKENKTED 203
Query: 344 VQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQ 401
E+ +E E E + D E + + E E E +E+ + ++
Sbjct: 204 RHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKE 261
Score = 37.4 bits (85), Expect = 0.060
Identities = 48/270 (17%), Positives = 103/270 (38%), Gaps = 14/270 (5%)
Query: 59 RARALRKRTQTLLKEYKERDKSNVFRDK---RFGEYNSNMSPEEKMMKRFALEQQRHHEK 115
+ R K Q + ++R+K N D+ R E E + ++ +++R ++
Sbjct: 177 KEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQR 236
Query: 116 KSIYNLNEDEELTHYGQSLADIEKHNDIV-----DSDSDAEDRGTLSAELTAAHFGGGGG 170
K+ + E + + +K + D D ++R +
Sbjct: 237 KTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRE 296
Query: 171 LLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRE----RQAQREDALELTEKLDQDWK 226
K+ +Q ERE+ ++RK E + ++ +RE R+ +RE + ++D++
Sbjct: 297 TERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN 356
Query: 227 EIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAEL-AKEEQEH 285
+ + E ++E+ + A + RE + Q +TE + + E E
Sbjct: 357 RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEK 416
Query: 286 LRKLEAERLRRMLGKDEDENVKKPKHMSAD 315
R+ E +R G++ +K K D
Sbjct: 417 QREREKDR-ESERGRERGREREKQKGRERD 445
Score = 30.0 bits (66), Expect = 9.5
Identities = 31/162 (19%), Positives = 67/162 (41%), Gaps = 24/162 (14%)
Query: 270 NRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRR 329
NR K E E +E+++ R+ + +R RR +++D + K+ +H + + DR
Sbjct: 57 NRQK-ERERRREKRQTERETDRKRERR---REKDRHRKRDRHRERQRDREKERERQTDRE 112
Query: 330 LLSYKDGKMNVEE------------------DVQEEQSKEASDPESNEEEGDSSGGEDTE 371
++ + N ++ D Q E+ ++ + E + D TE
Sbjct: 113 RDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE 172
Query: 372 ESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKER 413
+ + + E N + E E+ +++ +T + G+ER
Sbjct: 173 RNRQKER--EREKNRQERRERERQREKENKTEDRHSERGRER 212
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 54.7 bits (130), Expect = 4e-07
Identities = 87/418 (20%), Positives = 157/418 (37%), Gaps = 64/418 (15%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLL 232
H + ++ ER K + R+E ++ + + ++ R+ RE + ++L+Q ++ +
Sbjct: 111 HARVKEREHERRK-RHREE--QDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 167
Query: 233 SHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAE 292
+ + E R++KE+ + RE E+ A + ++ K
Sbjct: 168 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 227
Query: 293 RLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV----EEDVQEEQ 348
R R LG D + VK+ K D L+D + +R+ S + EE+ +EE+
Sbjct: 228 RERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 286
Query: 349 SKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLI 408
+E S E E + E+ EE +S E + E E E E+R+ L+
Sbjct: 287 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 346
Query: 409 --------------SGKERAGKAT-----------------------RDELPYTFAAPE- 430
+E G+ T + ELP A +
Sbjct: 347 VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQG 406
Query: 431 --SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF---LLEYVGDL 484
S EE + L R E VV R + + + K+EK GF L + +
Sbjct: 407 CRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI 464
Query: 485 ATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKGRAALPG 542
P++ + ++VV S D I V+ H+++ ++ET + LPG
Sbjct: 465 LKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/349 (20%), Positives = 143/349 (40%), Gaps = 41/349 (11%)
Query: 85 DKRFGEYNSNMSPEEKM-MKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDI 143
D+ E EEK +KR R ++ S+ E+ EL + +I N
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSL----EEGELRDH---CMEITIRNSP 66
Query: 144 VDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQE 203
+ EDRG L + +++E K + RKE + K ++
Sbjct: 67 YRREDSMEDRGEEDDSLAIKP-------PQQMSRKEKVHHRKDEKRKEKWKHARVKEREH 119
Query: 204 KRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEK-PKPDAYDMMVRELGF 262
+R ++ + E +K ++W+ + + RD+ E+ + + +RE
Sbjct: 120 ERRKRHREEQ-----DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 174
Query: 263 EMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSAD------- 315
E + Q + AE ++E+E R++ A R + +D + VK H S
Sbjct: 175 EQREQKERERR--AEERRKEREARREVSAHH--RTMREDYSDKVKA-SHWSRSPPRPPRE 229
Query: 316 --DLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEES 373
+L DG K+++ + +D +++ D+ + + K +S S+ E G S E+ EE
Sbjct: 230 RFELGDGRKPVKEEK--MEERDLLSDLQ-DISDSERKTSSAESSSAESGSGSEEEEEEEE 286
Query: 374 DSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDEL 422
+ + E + E EEE E +E+ +T + ++ A + + +E+
Sbjct: 287 EEEEEGSTSEESEEEEEEEE---EEEEETGSNSEEASEQSAEEVSEEEM 332
Score = 35.8 bits (81), Expect = 0.17
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 28/165 (16%)
Query: 72 KEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYG 131
+E K R++ R+++ E + EE+ +R A + H + + ++ + +H+
Sbjct: 165 RERKMREQQKEQREQKERERRA----EERRKEREARREVSAHHRTMREDYSDKVKASHWS 220
Query: 132 QS----------LADIEK--------HNDIVDSDSDAED--RGTLSAELTAAHFGGGGGL 171
+S L D K D++ D D R T SAE ++A G G
Sbjct: 221 RSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-- 278
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE 216
++ ++E EE E+ S E EE + ++E+ E + E+A E
Sbjct: 279 --EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 321
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 54.7 bits (130), Expect = 4e-07
Identities = 93/464 (20%), Positives = 190/464 (40%), Gaps = 94/464 (20%)
Query: 33 EVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYN 92
E + + K +I G K ++ + + K Q ++ +E K N F+ +
Sbjct: 636 EREKEKHKKEIEGEKEKY--------KTKDSAKELQRSVEFDREFWKENFFKSDETEDLF 687
Query: 93 SNMSPE----------EKMMKRFALEQQRHHEKKSIYN-----LNEDEELTHYGQSLADI 137
NM E EK +K +++H K+ + + ++ E + + + D+
Sbjct: 688 LNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDL 747
Query: 138 EKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEER------EKPKSRKE 191
++ + + +D D+E S ++A G L+ K+ E +E+ EKP+ R +
Sbjct: 748 KEERENIPTDKDSE---FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 804
Query: 192 LIEELIAKSKQEKRERQAQ-------REDALELTEKLDQDWKEIQTLLSHKTPK------ 238
+ E+ I K +++ E++ + +D L+L+E +D+ KE L SH T K
Sbjct: 805 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKI-KEKDKLYSHHTEKCHKEGE 863
Query: 239 ----------SENRDK----------KEKPKPDAYDMMVRELGFEMK----AQPSNRMKT 274
+++R+K KEKP+ + + +E K + S K+
Sbjct: 864 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 923
Query: 275 EAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYK 334
E KE+ L K E R + + +++++ K S D N +
Sbjct: 924 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK------------AQH 971
Query: 335 DGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEK 394
+ ++++E ++E K P+ E++ + +E D + + S ++ + E +K
Sbjct: 972 EKPLSLKEKTKDEPLK---TPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1028
Query: 395 PAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSL 438
P + + +P KE+ + D+L T S+E + SL
Sbjct: 1029 P--KPKSSPASKDTRPKEK--RLVNDDLMQT-----SFERMLSL 1063
Score = 45.1 bits (105), Expect = 3e-04
Identities = 67/304 (22%), Positives = 128/304 (42%), Gaps = 20/304 (6%)
Query: 181 EEREKPKSRK----ELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQT-LLSHK 235
+ +EK K +K E E+ AK K E + D +K+D++ K ++ L HK
Sbjct: 578 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT--LKKMDKEGKTLKKHKLKHK 635
Query: 236 TPKSENRDK-----KEKPKP-DAYDMMVRELGFEMKAQPSNRMKT-EAELAKEEQEHLRK 288
+ E K KEK K D+ + R + F+ + N K+ E E EH
Sbjct: 636 EREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEH-ES 694
Query: 289 LEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQ 348
L E+ ++ +D+ K KH+S + F ++D + S K + +D++EE+
Sbjct: 695 LTLEKKSKLEKNIKDDKSTKEKHVSKER---NFKEERDKIKKESEKSFREEKIKDLKEER 751
Query: 349 SKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLI 408
+D +S S E++ + +D+E + +E+++ +++ Q K I
Sbjct: 752 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKD-I 810
Query: 409 SGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKA 468
ER ++ + + + +L S + + E+ L +KC+ N A
Sbjct: 811 EKMERKTFEKEKKIKHEHKSEKDKLDL-SECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 869
Query: 469 KLEK 472
++K
Sbjct: 870 AIKK 873
Score = 39.3 bits (90), Expect = 0.016
Identities = 69/367 (18%), Positives = 148/367 (40%), Gaps = 48/367 (13%)
Query: 61 RALRKRTQTLLK---EYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKS 117
+ + K +TL K ++KER+K ++ + K ++R ++E R K++
Sbjct: 618 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQR-SVEFDREFWKEN 676
Query: 118 IYNLNEDEEL-THYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKT 176
+ +E E+L + +EK + + + D D+ T ++ ++
Sbjct: 677 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD--DKSTKEKHVSK-----------ERN 723
Query: 177 QQEGEEREKPKSRKELIEELIAKSKQEKRERQAQRED--------ALELTEKLDQDWKEI 228
+E ++ K +S K EE I K+E+ ++ A+E + L KEI
Sbjct: 724 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 783
Query: 229 QTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRK 288
K E K+ K KP+ + + +++ + E ++ E + K
Sbjct: 784 DI------EKQEKHIKESKEKPEKRSQIKEK---DIEKMERKTFEKEKKIKHEHKSEKDK 834
Query: 289 LE-AERLRRMLGKDE--DENVKKPKHMSADDLNDGFVLDKDDRRL----LSYKDGKMNVE 341
L+ +E + ++ KD+ + +K N + DDR + K K E
Sbjct: 835 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 894
Query: 342 EDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE------NEKP 395
++ +SKE E ++ D+S +E+ + + +L+ +S ++ N K
Sbjct: 895 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 954
Query: 396 AKEQRQT 402
+E++++
Sbjct: 955 IQEEKKS 961
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 54.7 bits (130), Expect = 4e-07
Identities = 93/464 (20%), Positives = 190/464 (40%), Gaps = 94/464 (20%)
Query: 33 EVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYN 92
E + + K +I G K ++ + + K Q ++ +E K N F+ +
Sbjct: 659 EREKEKHKKEIEGEKEKY--------KTKDSAKELQRSVEFDREFWKENFFKSDETEDLF 710
Query: 93 SNMSPE----------EKMMKRFALEQQRHHEKKSIYN-----LNEDEELTHYGQSLADI 137
NM E EK +K +++H K+ + + ++ E + + + D+
Sbjct: 711 LNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDL 770
Query: 138 EKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEER------EKPKSRKE 191
++ + + +D D+E S ++A G L+ K+ E +E+ EKP+ R +
Sbjct: 771 KEERENIPTDKDSE---FTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 827
Query: 192 LIEELIAKSKQEKRERQAQ-------REDALELTEKLDQDWKEIQTLLSHKTPK------ 238
+ E+ I K +++ E++ + +D L+L+E +D+ KE L SH T K
Sbjct: 828 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKI-KEKDKLYSHHTEKCHKEGE 886
Query: 239 ----------SENRDK----------KEKPKPDAYDMMVRELGFEMK----AQPSNRMKT 274
+++R+K KEKP+ + + +E K + S K+
Sbjct: 887 KSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKS 946
Query: 275 EAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYK 334
E KE+ L K E R + + +++++ K S D N +
Sbjct: 947 EKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK------------AQH 994
Query: 335 DGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEK 394
+ ++++E ++E K P+ E++ + +E D + + S ++ + E +K
Sbjct: 995 EKPLSLKEKTKDEPLK---TPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADK 1051
Query: 395 PAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSL 438
P + + +P KE+ + D+L T S+E + SL
Sbjct: 1052 P--KPKSSPASKDTRPKEK--RLVNDDLMQT-----SFERMLSL 1086
Score = 45.1 bits (105), Expect = 3e-04
Identities = 67/304 (22%), Positives = 128/304 (42%), Gaps = 20/304 (6%)
Query: 181 EEREKPKSRK----ELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQT-LLSHK 235
+ +EK K +K E E+ AK K E + D +K+D++ K ++ L HK
Sbjct: 601 KHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCT--LKKMDKEGKTLKKHKLKHK 658
Query: 236 TPKSENRDK-----KEKPKP-DAYDMMVRELGFEMKAQPSNRMKT-EAELAKEEQEHLRK 288
+ E K KEK K D+ + R + F+ + N K+ E E EH
Sbjct: 659 EREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEH-ES 717
Query: 289 LEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQ 348
L E+ ++ +D+ K KH+S + F ++D + S K + +D++EE+
Sbjct: 718 LTLEKKSKLEKNIKDDKSTKEKHVSKER---NFKEERDKIKKESEKSFREEKIKDLKEER 774
Query: 349 SKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLI 408
+D +S S E++ + +D+E + +E+++ +++ Q K I
Sbjct: 775 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKD-I 833
Query: 409 SGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKA 468
ER ++ + + + +L S + + E+ L +KC+ N A
Sbjct: 834 EKMERKTFEKEKKIKHEHKSEKDKLDL-SECVDKIKEKDKLYSHHTEKCHKEGEKSKNTA 892
Query: 469 KLEK 472
++K
Sbjct: 893 AIKK 896
Score = 39.3 bits (90), Expect = 0.016
Identities = 69/367 (18%), Positives = 148/367 (40%), Gaps = 48/367 (13%)
Query: 61 RALRKRTQTLLK---EYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKS 117
+ + K +TL K ++KER+K ++ + K ++R ++E R K++
Sbjct: 641 KKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQR-SVEFDREFWKEN 699
Query: 118 IYNLNEDEEL-THYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKT 176
+ +E E+L + +EK + + + D D+ T ++ ++
Sbjct: 700 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD--DKSTKEKHVSK-----------ERN 746
Query: 177 QQEGEEREKPKSRKELIEELIAKSKQEKRERQAQRED--------ALELTEKLDQDWKEI 228
+E ++ K +S K EE I K+E+ ++ A+E + L KEI
Sbjct: 747 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 806
Query: 229 QTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRK 288
K E K+ K KP+ + + +++ + E ++ E + K
Sbjct: 807 DI------EKQEKHIKESKEKPEKRSQIKEK---DIEKMERKTFEKEKKIKHEHKSEKDK 857
Query: 289 LE-AERLRRMLGKDE--DENVKKPKHMSADDLNDGFVLDKDDRRL----LSYKDGKMNVE 341
L+ +E + ++ KD+ + +K N + DDR + K K E
Sbjct: 858 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE 917
Query: 342 EDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE------NEKP 395
++ +SKE E ++ D+S +E+ + + +L+ +S ++ N K
Sbjct: 918 KERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH 977
Query: 396 AKEQRQT 402
+E++++
Sbjct: 978 IQEEKKS 984
>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
sapiens]
Length = 1150
Score = 54.3 bits (129), Expect = 5e-07
Identities = 52/252 (20%), Positives = 105/252 (41%), Gaps = 33/252 (13%)
Query: 174 KKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTE-------------- 219
K +Q+ E++E KS KE E+ KS+ +K E + +R++ +E
Sbjct: 671 KVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAII 730
Query: 220 ----------KLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPS 269
K D + LL ++ ++ + + ++ M++ F ++ S
Sbjct: 731 VHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQR-DFGVRIYKS 789
Query: 270 NRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRR 329
E E KE+ + +K ER + +D++ + KPK + D D D+D+R+
Sbjct: 790 LLSLPEKEDKKEKDKKSKK--DERKDKKEERDDETDEPKPKRRKSGDDKDKKE-DRDERK 846
Query: 330 LLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESE 389
+ +++ +E+ +++ DP EE D D EE D D+ +
Sbjct: 847 KEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDDKRDINRYCK-- 904
Query: 390 EENEKPAKEQRQ 401
E+P+K++ +
Sbjct: 905 ---ERPSKDKEK 913
Score = 35.4 bits (80), Expect = 0.23
Identities = 76/375 (20%), Positives = 151/375 (40%), Gaps = 55/375 (14%)
Query: 30 NPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALRK-RTQTLLKEYKERDKSNVFRDKRF 88
+P +KVN + ++ R GL AR ++ + + +E KE +KS D+
Sbjct: 635 DPKTMKVNDLRKELESRALSSK-GLKSQLIARLTKQLKVEEQKEEQKELEKSEKEEDEDD 693
Query: 89 GEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDS-- 146
+ + EE+ ++ +E+QR + Y L ++ + + A K + + S
Sbjct: 694 DRKSEDDKEEEERKRQEEIERQRRERR---YILPDEPAIIVHPNWAAKSGKFDCSIMSLS 750
Query: 147 ---DSDAEDR----------GTLSAELTAAHFG-----GGGGLLHKKTQQEGEEREKPKS 188
D ED L E+ FG L K+ ++E +++ K
Sbjct: 751 VLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKEKDKKSKKDE 810
Query: 189 RKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKP 248
RK+ EE ++ + K +R+ +D +K D+D ++ + K ++ + +E
Sbjct: 811 RKDKKEERDDETDEPKPKRRKSGDDK---DKKEDRDERKKED--KRKDDSKDDDETEEDN 865
Query: 249 KPDAYDMMVRELGFEMKAQPSNRMKTEAELAK-EEQEHLRKLEAERLRRMLGKDEDENVK 307
D YD M E +A+ + E E+ K +++ + + ER + K++ + +
Sbjct: 866 NQDEYDPMEAE-----EAEDEEDDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMIT 920
Query: 308 KPKHMSA-----DDLNDGFVLDKDDRRLLSYKDG-------------KMNVEEDVQEEQS 349
+ + D + G++L+KD +L Y G K+ + E +
Sbjct: 921 INRDLLMAFVYFDQSHCGYLLEKDLEEIL-YTLGLHLSRAQVKKLLNKVVLRESCFYRKL 979
Query: 350 KEASDPESNEEEGDS 364
+ S E N EE +S
Sbjct: 980 TDTSKDEENHEESES 994
Score = 30.0 bits (66), Expect = 9.5
Identities = 24/113 (21%), Positives = 46/113 (40%), Gaps = 17/113 (15%)
Query: 135 ADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIE 194
A++E+ +++ +D +++ L+ E + GE RE K +L E
Sbjct: 1049 AEVEQKLQLLEEKTDEDEKTILNLE-------------NSNKSLSGELREVKKDLSQLQE 1095
Query: 195 ELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEK 247
L + + L+ +D EI T+L K+E++D+K K
Sbjct: 1096 NLKISENMNLQFENQMNKTIRNLSTVMD----EIHTVLKKDNVKNEDKDQKSK 1144
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 54.3 bits (129), Expect = 5e-07
Identities = 72/310 (23%), Positives = 126/310 (40%), Gaps = 36/310 (11%)
Query: 122 NEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGE 181
+E++E + S ++ E+ + DSDS++E+R AE A+ H + E
Sbjct: 69 SENDEPLNLNASDSESEELHRQKDSDSESEER----AEPPASDSENEDVNQHGSDSESEE 124
Query: 182 EREKPKS---RKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPK 238
R+ P S +EL+ + S+ E + + +E +K E + L +
Sbjct: 125 TRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISD 184
Query: 239 SENRD----------KKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRK 288
SE+ + +E PKP D EL + + + + E E L K
Sbjct: 185 SESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPK 244
Query: 289 -----LEAERLRRMLGKD-EDENVKKPK--HMSADDLNDGFVLDKDDRRLL------SYK 334
E+E R D E+E + KP+ ++D D ++ L S
Sbjct: 245 PRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSES 304
Query: 335 DG--KMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTE---ESDSPDSHLDLESNVESE 389
+G K + E+ S+ PES+++ + GEDTE +S DSH+D + S+
Sbjct: 305 EGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSD 364
Query: 390 EENEKPAKEQ 399
E E+ K++
Sbjct: 365 SEEEEHKKQK 374
Score = 48.1 bits (113), Expect = 3e-05
Identities = 78/353 (22%), Positives = 137/353 (38%), Gaps = 45/353 (12%)
Query: 89 GEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDS 148
G++ ++ S E++ K A + + K + +E EE + S ++ E+ SDS
Sbjct: 152 GKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDS 211
Query: 149 DAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPK-----------------SRKE 191
++E+ + + H+ + E EE KP+ +E
Sbjct: 212 ESEELPKPQVSDSESEEPPR----HQASDSENEELPKPRISDSESEDPPRHQASDSENEE 267
Query: 192 LIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRD-KKEKPKP 250
L + I+ S+ E R + E K E + SE D + K KP
Sbjct: 268 LPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKP 327
Query: 251 DAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDED------E 304
++ D RE E ++ +++ + +++ E E ++ + DED E
Sbjct: 328 ESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEE 387
Query: 305 NVKKPKHMSADDLND---------GFVLDKD--DRRLLSYKDGK--MNVEEDVQEEQSKE 351
V K K D D V D D D +S K GK + D +EE KE
Sbjct: 388 KVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKE 447
Query: 352 ASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE----NEKPAKEQR 400
SD ++ E++ S E E ++ + + ES E EEE N++ +E++
Sbjct: 448 LSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEK 500
Score = 40.4 bits (93), Expect = 0.007
Identities = 64/304 (21%), Positives = 111/304 (36%), Gaps = 74/304 (24%)
Query: 173 HKKTQQEGEEREKPKSRKELIEE----LIAKSKQEKRERQAQREDALELTEKLDQDWKEI 228
H+ + E EE KP+ E+ + S+ E+ + + E +K E
Sbjct: 258 HQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSET 317
Query: 229 QTLLSHKTPKSENRDKKEKPKPDAYDM----------MVRELGFEMKAQPSNRMKTEAEL 278
+ HK + D + K + +M M R+ ++ K + +
Sbjct: 318 EDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDS 377
Query: 279 AKEEQEHLRKLEAERLRRMLGKDEDE---NVKKPKHMS-ADDLNDGFVLDKDDRRLLSYK 334
++E+E + A+R +L EDE + KK + +S ADD + V DK +R
Sbjct: 378 DEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKR----- 432
Query: 335 DGKMNVEEDVQEEQSKEASDPESNEEE---GDSSGG------------------------ 367
+ + D +EE KE SD ++ E++ DS G
Sbjct: 433 --EKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTG 490
Query: 368 ---------------EDTEESDSPDS-----HLDLESNVESEEENEK--PAKEQRQTPGK 405
++ E+SDS D+ H+D S+ E + +K K +R G
Sbjct: 491 FNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGG 550
Query: 406 GLIS 409
IS
Sbjct: 551 TFIS 554
Score = 35.0 bits (79), Expect = 0.30
Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 17/105 (16%)
Query: 310 KHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEED--------VQEEQSKEASDPESNEEE 361
++ S D +DG D R S DG+ +V E V+ E SD E +
Sbjct: 4 EYYSGDQSDDGGATPVQDERD-SGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
Query: 362 G----DSSGGE----DTEESDSPDSHLDLESNVESEEENEKPAKE 398
G DS E + +S+S + H +S+ ESEE E PA +
Sbjct: 63 GHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASD 107
Score = 33.1 bits (74), Expect = 1.1
Identities = 61/296 (20%), Positives = 105/296 (35%), Gaps = 82/296 (27%)
Query: 145 DSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEK 204
DS SD ED ++ H G G + + ++ E +RE + + + E
Sbjct: 24 DSGSDGED------DVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD---SENDEP 74
Query: 205 RERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEM 264
A ++ EL + D D SE+ ++ E P D+ + V + G +
Sbjct: 75 LNLNASDSESEELHRQKDSD--------------SESEERAEPPASDSENEDVNQHGSDS 120
Query: 265 KAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLD 324
E+E R++ G D + ++L +G D
Sbjct: 121 -------------------------ESEETRKLPGSDSEN----------EELLNGHASD 145
Query: 325 KDDRRLLSYKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLES 384
++ EDV + ASD E E + + +TE++ P D ES
Sbjct: 146 SEN--------------EDVGKH---PASDSEIEELQKSPASDSETEDALKPQIS-DSES 187
Query: 385 -----NVESEEENEKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEEL 435
+ S+ ENE+P K R + + K + + +E P A+ EEL
Sbjct: 188 EEPPRHQASDSENEEPPK-PRMSDSESEELPKPQVSDSESEEPPRHQASDSENEEL 242
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 53.9 bits (128), Expect = 6e-07
Identities = 87/426 (20%), Positives = 157/426 (36%), Gaps = 69/426 (16%)
Query: 173 HKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE--------LTEKLDQD 224
H + +++ E E+ K +E ++ + +++KR A+ E ++L+Q
Sbjct: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 169
Query: 225 WKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQE 284
++ + + + E R++KE+ + RE E+ A + ++ K
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 229
Query: 285 HLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNV---- 340
R R LG D + VK+ K D L+D + +R+ S +
Sbjct: 230 SRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 288
Query: 341 EEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQR 400
EE+ +EE+ +E S E E + E+ EE +S E + E E E E+R
Sbjct: 289 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER 348
Query: 401 QTPGKGLI--------------SGKERAGKAT-----------------------RDELP 423
+ L+ +E G+ T + ELP
Sbjct: 349 ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELP 408
Query: 424 YTFAAPE---SYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEK-LFGF--- 476
A + S EE + L R E VV R + + + K+EK GF
Sbjct: 409 KYLPALQGCRSVEEFQ--CLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPIT 466
Query: 477 LLEYVGDLATDDPPDLTVIDKLVVHLYHLCQMFPESASDAIKFVLRDAMHEMEEMIETKG 536
L + + P++ + ++VV S D I V+ H+++ ++ET
Sbjct: 467 SLREINTILKAQHPNIVTVREIVV----------GSNMDKIYIVMNYVEHDLKSLMETMK 516
Query: 537 RAALPG 542
+ LPG
Sbjct: 517 QPFLPG 522
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/310 (19%), Positives = 119/310 (38%), Gaps = 29/310 (9%)
Query: 139 KHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEERE----KPK---SRKE 191
K++D DS D+ + G L + GEE + KP SRKE
Sbjct: 36 KNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 95
Query: 192 LIEELIAKSKQEK---RERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKP 248
+ + ++EK R ++ +RE + +QD + + + ++E+
Sbjct: 96 KVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERG 155
Query: 249 KPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKK 308
R E K + +M+ + + +E++E R+ E R R ++ + +
Sbjct: 156 NDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRT 215
Query: 309 PKHMSADDLNDGFVL---DKDDRRLLSYKDGKMNVEE-------------DVQEEQSKEA 352
+ +D + + R DG+ V+E D+ + + K +
Sbjct: 216 MREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTS 275
Query: 353 SDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTPGKGLISGKE 412
S S+ E G S E+ EE + + E + E EEE E +E+ +T + ++
Sbjct: 276 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEE---EEEEETGSNSEEASEQ 332
Query: 413 RAGKATRDEL 422
A + + +E+
Sbjct: 333 SAEEVSEEEM 342
Score = 38.5 bits (88), Expect = 0.027
Identities = 49/201 (24%), Positives = 89/201 (44%), Gaps = 30/201 (14%)
Query: 38 RQKFQILGRK-TRHDVGLPGVSRAR-ALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNM 95
RQK + + R+ +R + G GV R L + + +E K R++ R+++ E +
Sbjct: 139 RQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRA-- 196
Query: 96 SPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQS----------LADIEK------ 139
EE+ +R A + H + + ++ + +H+ +S L D K
Sbjct: 197 --EERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEK 254
Query: 140 --HNDIVDSDSDAED--RGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEE 195
D++ D D R T SAE ++A G G ++ ++E EE E+ S E EE
Sbjct: 255 MEERDLLSDLQDISDSERKTSSAESSSAESGSGS----EEEEEEEEEEEEEGSTSEESEE 310
Query: 196 LIAKSKQEKRERQAQREDALE 216
+ ++E+ E + E+A E
Sbjct: 311 EEEEEEEEEEETGSNSEEASE 331
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 52.8 bits (125), Expect = 1e-06
Identities = 70/346 (20%), Positives = 149/346 (43%), Gaps = 22/346 (6%)
Query: 65 KRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMMKRFALEQQRHHEKKSIYNLNED 124
++T+ Y +D + F D GE + +++ FA E QR S ++ D
Sbjct: 100 QKTELETALYYSQDAARKFEDGNLGE-SKDLAGRLHHSWHFAGELQRALSAVSTWHKKAD 158
Query: 125 ---EELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGE 181
EELT +L+ +E + + + ++ + L +L A L+ K +
Sbjct: 159 RYIEELTKERDALS-LELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKL 217
Query: 182 EREK---PKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPK 238
ER K P+ + ++E + + ++E RE++ + E + ++ +E + + + K
Sbjct: 218 ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK 277
Query: 239 SENRDKKEKPKPDAYDMMVRELGFEMK-AQPSNRMKTEAELAKEEQEHLRKLEAERLRRM 297
++K+ + + +EL + K + +M+ + E E++E +R+ E + R+
Sbjct: 278 MRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 337
Query: 298 LGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEASDPES 357
E E + + D + + ++D+R L K+ +M +E + E++ K +
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEER-MWEQDER--LREKEERMREQEKMWEQEEKMQEEERI 394
Query: 358 NEEEGDSSGGEDTEESDSPDSHLDLESNVESEEEN--EKPAKEQRQ 401
E E E+T + E ++ +EEN E+ KE +Q
Sbjct: 395 REREKKMREEEETMR--------EQEEKMQKQEENMWEQEEKEWQQ 432
Score = 47.8 bits (112), Expect = 4e-05
Identities = 59/340 (17%), Positives = 146/340 (42%), Gaps = 34/340 (10%)
Query: 59 RARALRKRTQTLLK--EYKERDKSNVFRDKRFGEYNSNMSPE--EKMMKRFALEQQRHHE 114
R + +R+ +T+ + E ++ + N++ + E+ PE EK+ ++ +++Q
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEE-KEWQQQRLPEQKEKLWEQEKMQEQEEKI 455
Query: 115 KKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHK 174
+ + + EE+ + + EK + D + E++ + K
Sbjct: 456 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ--------------K 501
Query: 175 KTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSH 234
QE E+ + +E E + + K ++E + + E + EK D +E
Sbjct: 502 MWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE------- 554
Query: 235 KTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEA--- 291
K + E ++EK + +MM RE +M+ Q +M+ + E E++E +++ E
Sbjct: 555 KMREEERMREREKKMREEEEMM-REQEEKMQEQ-EEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 292 ERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKE 351
E+ +M ++E++ +++ + M + + + + ++ ++ EE ++E++ K
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMMWEQEEK---MQEQEEKMWEQEEKMREQEEKMREQEEKM 669
Query: 352 ASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE 391
E E+ + G++ + + + E + +EE
Sbjct: 670 QGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Score = 44.7 bits (104), Expect = 4e-04
Identities = 44/243 (18%), Positives = 108/243 (44%), Gaps = 13/243 (5%)
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKS-KQEKR---ERQAQREDALELTEKLDQDWKE 227
L ++ +Q E+ EK ++E + E K +QE+R + + RE ++ ++ ++ W++
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364
Query: 228 IQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLR 287
+ L + E E+ + + +RE +M+ + + E ++ K+E+
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 288 KLEAERLRRMLGKDEDENVKKPKHMSADDL---NDGFVLDKDD---RRLLSYKDGKMNVE 341
+ E E ++ L + +++ ++ K ++ + + D+++ + ++ KM +
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 342 EDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEE---NEKPAKE 398
ED EQ ++ D E + + E E + + + + +EE EK +E
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 399 QRQ 401
Q +
Sbjct: 545 QEK 547
Score = 44.7 bits (104), Expect = 4e-04
Identities = 43/246 (17%), Positives = 105/246 (42%), Gaps = 25/246 (10%)
Query: 174 KKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLS 233
K QQE + RE+ K++++ + + K + ER +RE + E++ ++ +E
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE------ 581
Query: 234 HKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLEAER 293
K + E + ++++ K + ++E +M Q + E E +EQE + + E+
Sbjct: 582 -KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK 640
Query: 294 LRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSKEAS 353
++ K ++ K + + + ++ ++ EE ++E++ K
Sbjct: 641 MQEQEEKMWEQEEK---------------MREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 354 DPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEE---ENEKPAKEQRQTPGKGLISG 410
E E+ + G++ + + E + +E E E+ ++Q++ + L
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEH 745
Query: 411 KERAGK 416
+ER +
Sbjct: 746 EERCSE 751
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 52.8 bits (125), Expect = 1e-06
Identities = 93/425 (21%), Positives = 164/425 (38%), Gaps = 64/425 (15%)
Query: 18 AGARGGPAKANSNPFEV--KVNRQKFQILGRKTRHDVGLPGVSRAR----------ALRK 65
AG+ GP + P + K+ + K + K +H + + AL
Sbjct: 416 AGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTA 475
Query: 66 RTQTLLKEYKERDKSNVFRDKRFGEYNSN-MSPEEKMMKRFALEQQRHHEKKSIYNLNED 124
T+ L KE K + E ++ ++ +K A E + +K E+
Sbjct: 476 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 535
Query: 125 EELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEERE 184
EE G E+ + S+ E+ E A G + E +E +
Sbjct: 536 EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG---------EEAEAKEEK 586
Query: 185 KPKSRKELI---EELIAKSKQEKRERQAQR--EDALELTEKLDQDWKEIQTLLSHKTPKS 239
K + + E + EEL+A +K EK E+ + +E K ++ PKS
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 240 ENRDKKEKPKPDAYDMMVRELG--------FEMKAQ------PSNRMKTEAELAKEEQEH 285
+K + P P + V E G E KA+ P K++AE+ K EQ
Sbjct: 647 PVEEKGKSPVPKS---PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ-- 701
Query: 286 LRKLEAERLRRMLGKDE--DENVKKPKHMSADDLNDGFVLDKDDRRLLSY-KDGKMNVEE 342
K E E+ + K+E ++ +KPK + + V ++ +++ K K+++E+
Sbjct: 702 --KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK 759
Query: 343 DVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPD--------SHLDLESNVESEEENEK 394
+ +EE P E+E + +GGE E + D + + VE +EE E+
Sbjct: 760 ETKEE-----GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ 814
Query: 395 PAKEQ 399
KE+
Sbjct: 815 ETKEK 819
Score = 48.9 bits (115), Expect = 2e-05
Identities = 58/233 (24%), Positives = 102/233 (43%), Gaps = 47/233 (20%)
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE-LTEKLDQDWKEIQT 230
+ K Q+ E K K + + +EE+I ++K E + +++ E+AL +TE+L
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVE--DEKSEMEEALTAITEEL--------- 480
Query: 231 LLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLE 290
+S K K E ++KE+ +P+A + V +KA + E E KEE+E + E
Sbjct: 481 AVSMKEEKKEAAEEKEE-EPEAEEEEVAAKKSPVKATAPEVKEEEGE--KEEEEGQEEEE 537
Query: 291 AERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSK 350
+EDE K +D +G S K+G EE QEE
Sbjct: 538 ----------EEDEGAK------SDQAEEGG----------SEKEGSSEKEEGEQEEGET 571
Query: 351 EASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTP 403
EA E EG+ + ++ ++ + + + + ++ + EKP K + P
Sbjct: 572 EA------EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 618
Score = 43.1 bits (100), Expect = 0.001
Identities = 68/319 (21%), Positives = 133/319 (41%), Gaps = 31/319 (9%)
Query: 96 SPEEKMMKRFA---LEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAED 152
+P+ K+ +F +E+ + ++KS +E LT + LA + + ++ + E+
Sbjct: 443 APKLKVQHKFVEEIIEETKVEDEKS----EMEEALTAITEELA-VSMKEEKKEAAEEKEE 497
Query: 153 RGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQRE 212
E AA + ++EGE+ E+ +E E+ AKS Q + E +++E
Sbjct: 498 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE-EGGSEKE 556
Query: 213 DALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRM 272
+ +EK + + +E +T + ++E +++K+ + EL + K + +
Sbjct: 557 GS---SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 613
Query: 273 KTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLS 332
K+ + E++ + + +E K P S + + K
Sbjct: 614 KSPVPKSPVEEKGKSPVPKSPV--------EEKGKSPVPKSPVEEKGKSPVPKSPVE--- 662
Query: 333 YKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSG----GEDTEESDSPDSHLDLESNVES 388
+ GK V + EE++K P+S EE S GE EE + E VE
Sbjct: 663 -EKGKSPVSKSPVEEKAKSPV-PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
Query: 389 EEENEK--PAKEQRQTPGK 405
+EE K P K++ ++P K
Sbjct: 721 KEEKPKDVPEKKKAESPVK 739
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/183 (21%), Positives = 71/183 (38%), Gaps = 27/183 (14%)
Query: 231 LLSHKTP----KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEA------ELAK 280
L +H+ P + K E PK V E+ E K + EA ELA
Sbjct: 423 LYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAV 482
Query: 281 EEQEHLRKLEAERLRRMLGKDEDENVKK-PKHMSADDLNDGFVLDKDDRRLLSYKDGKMN 339
+E ++ E+ ++E+ KK P +A ++ + ++G+
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE--------------EEGEKE 528
Query: 340 VEEDVQEEQSKEASDPESNEEEGDS--SGGEDTEESDSPDSHLDLESNVESEEENEKPAK 397
EE +EE+ ++ EEG S G + EE + + + E+ E E E+
Sbjct: 529 EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV 588
Query: 398 EQR 400
E++
Sbjct: 589 EEK 591
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 52.8 bits (125), Expect = 1e-06
Identities = 93/425 (21%), Positives = 164/425 (38%), Gaps = 64/425 (15%)
Query: 18 AGARGGPAKANSNPFEV--KVNRQKFQILGRKTRHDVGLPGVSRAR----------ALRK 65
AG+ GP + P + K+ + K + K +H + + AL
Sbjct: 40 AGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTA 99
Query: 66 RTQTLLKEYKERDKSNVFRDKRFGEYNSN-MSPEEKMMKRFALEQQRHHEKKSIYNLNED 124
T+ L KE K + E ++ ++ +K A E + +K E+
Sbjct: 100 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 159
Query: 125 EELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAELTAAHFGGGGGLLHKKTQQEGEERE 184
EE G E+ + S+ E+ E A G + E +E +
Sbjct: 160 EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG---------EEAEAKEEK 210
Query: 185 KPKSRKELI---EELIAKSKQEKRERQAQR--EDALELTEKLDQDWKEIQTLLSHKTPKS 239
K + + E + EEL+A +K EK E+ + +E K ++ PKS
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
Query: 240 ENRDKKEKPKPDAYDMMVRELG--------FEMKAQ------PSNRMKTEAELAKEEQEH 285
+K + P P + V E G E KA+ P K++AE+ K EQ
Sbjct: 271 PVEEKGKSPVPKS---PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ-- 325
Query: 286 LRKLEAERLRRMLGKDE--DENVKKPKHMSADDLNDGFVLDKDDRRLLSY-KDGKMNVEE 342
K E E+ + K+E ++ +KPK + + V ++ +++ K K+++E+
Sbjct: 326 --KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK 383
Query: 343 DVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPD--------SHLDLESNVESEEENEK 394
+ +EE P E+E + +GGE E + D + + VE +EE E+
Sbjct: 384 ETKEE-----GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ 438
Query: 395 PAKEQ 399
KE+
Sbjct: 439 ETKEK 443
Score = 48.9 bits (115), Expect = 2e-05
Identities = 58/233 (24%), Positives = 102/233 (43%), Gaps = 47/233 (20%)
Query: 172 LHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALE-LTEKLDQDWKEIQT 230
+ K Q+ E K K + + +EE+I ++K E + +++ E+AL +TE+L
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVE--DEKSEMEEALTAITEEL--------- 104
Query: 231 LLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKEEQEHLRKLE 290
+S K K E ++KE+ +P+A + V +KA + E E KEE+E + E
Sbjct: 105 AVSMKEEKKEAAEEKEE-EPEAEEEEVAAKKSPVKATAPEVKEEEGE--KEEEEGQEEEE 161
Query: 291 AERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYKDGKMNVEEDVQEEQSK 350
+EDE K +D +G S K+G EE QEE
Sbjct: 162 ----------EEDEGAK------SDQAEEGG----------SEKEGSSEKEEGEQEEGET 195
Query: 351 EASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEENEKPAKEQRQTP 403
EA E EG+ + ++ ++ + + + + ++ + EKP K + P
Sbjct: 196 EA------EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
Score = 43.1 bits (100), Expect = 0.001
Identities = 68/319 (21%), Positives = 133/319 (41%), Gaps = 31/319 (9%)
Query: 96 SPEEKMMKRFA---LEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAED 152
+P+ K+ +F +E+ + ++KS +E LT + LA + + ++ + E+
Sbjct: 67 APKLKVQHKFVEEIIEETKVEDEKS----EMEEALTAITEELA-VSMKEEKKEAAEEKEE 121
Query: 153 RGTLSAELTAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQRE 212
E AA + ++EGE+ E+ +E E+ AKS Q + E +++E
Sbjct: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE-EGGSEKE 180
Query: 213 DALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRM 272
+ +EK + + +E +T + ++E +++K+ + EL + K + +
Sbjct: 181 GS---SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237
Query: 273 KTEAELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLS 332
K+ + E++ + + +E K P S + + K
Sbjct: 238 KSPVPKSPVEEKGKSPVPKSPV--------EEKGKSPVPKSPVEEKGKSPVPKSPVE--- 286
Query: 333 YKDGKMNVEEDVQEEQSKEASDPESNEEEGDSSG----GEDTEESDSPDSHLDLESNVES 388
+ GK V + EE++K P+S EE S GE EE + E VE
Sbjct: 287 -EKGKSPVSKSPVEEKAKSPV-PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 344
Query: 389 EEENEK--PAKEQRQTPGK 405
+EE K P K++ ++P K
Sbjct: 345 KEEKPKDVPEKKKAESPVK 363
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/183 (21%), Positives = 71/183 (38%), Gaps = 27/183 (14%)
Query: 231 LLSHKTP----KSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEA------ELAK 280
L +H+ P + K E PK V E+ E K + EA ELA
Sbjct: 47 LYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAV 106
Query: 281 EEQEHLRKLEAERLRRMLGKDEDENVKK-PKHMSADDLNDGFVLDKDDRRLLSYKDGKMN 339
+E ++ E+ ++E+ KK P +A ++ + ++G+
Sbjct: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE--------------EEGEKE 152
Query: 340 VEEDVQEEQSKEASDPESNEEEGDS--SGGEDTEESDSPDSHLDLESNVESEEENEKPAK 397
EE +EE+ ++ EEG S G + EE + + + E+ E E E+
Sbjct: 153 EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV 212
Query: 398 EQR 400
E++
Sbjct: 213 EEK 215
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,361,554
Number of Sequences: 37866
Number of extensions: 1624651
Number of successful extensions: 17223
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 282
Number of HSP's successfully gapped in prelim test: 933
Number of HSP's that attempted gapping in prelim test: 8906
Number of HSP's gapped (non-prelim): 5245
length of query: 857
length of database: 18,247,518
effective HSP length: 111
effective length of query: 746
effective length of database: 14,044,392
effective search space: 10477116432
effective search space used: 10477116432
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.