Search of human proteins with 55769548

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55769548 PHD finger protein 14 isoform 2 [Homo sapiens]
         (888 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55769548 PHD finger protein 14 isoform 2 [Homo sapiens]           1806   0.0  
gi|55769550 PHD finger protein 14 isoform 1 [Homo sapiens]           1800   0.0  
gi|57546899 myeloid/lymphoid or mixed-lineage leukemia transloca...   143   8e-34
gi|4757726 myeloid/lymphoid or mixed-lineage leukemia translocat...   143   8e-34
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora...   134   4e-31
gi|40556393 PHD finger protein 17 long isoform [Homo sapiens]         132   1e-30
gi|40556370 PHD finger protein 15 [Homo sapiens]                      132   2e-30
gi|19923609 PHD finger protein 17 short isoform [Homo sapiens]        131   3e-30
gi|117190334 PHD finger protein 16 [Homo sapiens]                     127   5e-29
gi|7662006 PHD finger protein 16 [Homo sapiens]                       127   5e-29
gi|51173722 bromodomain and PHD finger-containing protein 1 isof...   114   3e-25
gi|51173720 bromodomain and PHD finger-containing protein 1 isof...   114   3e-25
gi|148727368 bromodomain and PHD finger containing, 3 [Homo sapi...   114   5e-25
gi|11321642 bromodomain containing protein 1 [Homo sapiens]           109   1e-23
gi|98986459 jumonji domain containing 2A [Homo sapiens]                91   5e-18
gi|226442889 jumonji domain containing 2C isoform 2 [Homo sapiens]     90   1e-17
gi|109255247 jumonji domain containing 2C isoform 1 [Homo sapiens]     90   1e-17
gi|45504380 jumonji domain containing 2B [Homo sapiens]                86   2e-16
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    75   3e-13
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    70   9e-12
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     67   1e-10
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     67   1e-10
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    66   2e-10
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    65   3e-10
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...    64   5e-10
gi|11067749 bromodomain containing protein 3 [Homo sapiens]            63   1e-09

>gi|55769548 PHD finger protein 14 isoform 2 [Homo sapiens]
          Length = 888

 Score = 1806 bits (4679), Expect = 0.0
 Identities = 888/888 (100%), Positives = 888/888 (100%)

Query: 1   MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD 60
           MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD
Sbjct: 1   MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD 60

Query: 61  SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120
           SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE
Sbjct: 61  SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120

Query: 121 KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP 180
           KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP
Sbjct: 121 KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP 180

Query: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240
           KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE
Sbjct: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240

Query: 241 DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE 300
           DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE
Sbjct: 241 DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE 300

Query: 301 DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI 360
           DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI
Sbjct: 301 DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI 360

Query: 361 MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI 420
           MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI
Sbjct: 361 MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI 420

Query: 421 DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE 480
           DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE
Sbjct: 421 DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE 480

Query: 481 AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR 540
           AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR
Sbjct: 481 AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR 540

Query: 541 LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT 600
           LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT
Sbjct: 541 LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT 600

Query: 601 SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK 660
           SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK
Sbjct: 601 SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK 660

Query: 661 LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST 720
           LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST
Sbjct: 661 LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST 720

Query: 721 LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG 780
           LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG
Sbjct: 721 LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG 780

Query: 781 SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE 840
           SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE
Sbjct: 781 SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE 840

Query: 841 EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS 888
           EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS
Sbjct: 841 EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS 888


>gi|55769550 PHD finger protein 14 isoform 1 [Homo sapiens]
          Length = 948

 Score = 1800 bits (4661), Expect = 0.0
 Identities = 885/885 (100%), Positives = 885/885 (100%)

Query: 1   MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD 60
           MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD
Sbjct: 1   MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD 60

Query: 61  SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120
           SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE
Sbjct: 61  SEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120

Query: 121 KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP 180
           KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP
Sbjct: 121 KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP 180

Query: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240
           KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE
Sbjct: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240

Query: 241 DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE 300
           DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE
Sbjct: 241 DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNE 300

Query: 301 DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI 360
           DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI
Sbjct: 301 DSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSI 360

Query: 361 MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI 420
           MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI
Sbjct: 361 MSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDI 420

Query: 421 DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE 480
           DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE
Sbjct: 421 DKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE 480

Query: 481 AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR 540
           AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR
Sbjct: 481 AAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINAR 540

Query: 541 LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT 600
           LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT
Sbjct: 541 LQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDT 600

Query: 601 SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK 660
           SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK
Sbjct: 601 SSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNK 660

Query: 661 LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST 720
           LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST
Sbjct: 661 LCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKTST 720

Query: 721 LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG 780
           LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG
Sbjct: 721 LPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAG 780

Query: 781 SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE 840
           SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE
Sbjct: 781 SSDMEADMAMETLPDGTKRSRRQIKEPVKFVPQDVPPEPKKIPIRNTRTRGRKRSFVPEE 840

Query: 841 EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVR 885
           EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVR
Sbjct: 841 EKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVR 885



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 3/106 (2%)

Query: 701 RAPKERKPSKKEGGTQKTSTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLT 760
           R P+ER+  +++   QK      +   C  CK   D   L+ CD C+L YH GCLDPPL 
Sbjct: 846 RVPRERR--QRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLK 903

Query: 761 RMPRKTKNSYWQCSECDQAGSSDMEADMAMETLPDGTKRSRRQIKE 806
           + P++T    W C ECD + S + E +   + +       ++  K+
Sbjct: 904 KSPKQTGYG-WICQECDSSSSKEDENEAERKNISQELNMEQKNPKK 948



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 16/65 (24%), Positives = 25/65 (38%), Gaps = 8/65 (12%)

Query: 322 CCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGV 381
           C  C G    D + +++CD C +  H GC       D  +  + + +   W C  C    
Sbjct: 871 CATCKGTG--DNENLVRCDECRLCYHFGCL------DPPLKKSPKQTGYGWICQECDSSS 922

Query: 382 SPSCE 386
           S   E
Sbjct: 923 SKEDE 927


>gi|57546899 myeloid/lymphoid or mixed-lineage leukemia translocated
           to, 10 isoform b [Homo sapiens]
          Length = 1011

 Score =  143 bits (360), Expect = 8e-34
 Identities = 86/277 (31%), Positives = 131/277 (47%), Gaps = 24/277 (8%)

Query: 298 SNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDN--CGITVHEGCYGVDG 355
           S++  + LE   + S ++M  I  CCVC  +     + ++ CD   C + VH+ CYG+  
Sbjct: 3   SSDRPVSLEDEVSHSMKEM--IGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGI-- 58

Query: 356 ESDSIMSSASENSTEPWFCDACKC---GVSPSCELCPNQDGIFKETDAGRWVHIVCALYV 412
                     +  T PWFC  C+         CELCP++DG  K TD G W H+VCALY+
Sbjct: 59  ---------VQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYI 109

Query: 413 PGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCED---PRFARTGVCISCDAGMCRAYFHV 469
           P V F ++  + P+ L  + + +Y  K C  C++      A TG C++C+   CR  FHV
Sbjct: 110 PEVQFANVSTMEPIVLQSVPHDRYN-KTCYICDEQGRESKAATGACMTCNKHGCRQAFHV 168

Query: 470 TCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQL 529
           TCAQ  GLL E          +  YCK H  +L +  +  N    QS    S   ++K  
Sbjct: 169 TCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHH 228

Query: 530 SPEAQ--ARINARLQQYRAKAELARSTRPQAWVPREK 564
             E +     +   Q+++ + E + +  P   V  EK
Sbjct: 229 EKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEK 265



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 45/199 (22%), Positives = 69/199 (34%), Gaps = 45/199 (22%)

Query: 115 KEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATE 174
           K  EKEK+K KEK+K ++K K++   S  +  S   TT  T     N S S         
Sbjct: 226 KHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSIS--------- 276

Query: 175 EQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDG 234
                    +L+R        +     ++  + S              G+  S+  GS+G
Sbjct: 277 --------GSLKRLEDTTARFTNANFQEVSAHTS-------------SGKDVSETRGSEG 315

Query: 235 DNEDDEDEGSGSDEDE----NDEGNDEDHSSPASEGGCKKKKSKVLSRN----------- 279
             +      SG    +     + G     +SP  +G        V S +           
Sbjct: 316 KGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFL 375

Query: 280 SADDEELTNDSLTLSQSKS 298
           S  D +L NDS + SQ  S
Sbjct: 376 SFTDSDLRNDSYSHSQQSS 394



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 5/93 (5%)

Query: 80  QLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKAT 139
           +LK S      S ++ L       ++++ E     KEK+K KEK+K K+K +++ +    
Sbjct: 200 KLKKSKRGSNRSYDQSLSDSSSHSQDKHHE-----KEKKKYKEKDKHKQKHKKQPEPSPA 254

Query: 140 VSENVAASAAATTPATSPPAVNTSPSVPTTTTA 172
           +  ++  +   T  +TS  +++ S      TTA
Sbjct: 255 LVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTA 287


>gi|4757726 myeloid/lymphoid or mixed-lineage leukemia translocated
           to, 10 isoform a [Homo sapiens]
          Length = 1027

 Score =  143 bits (360), Expect = 8e-34
 Identities = 86/277 (31%), Positives = 131/277 (47%), Gaps = 24/277 (8%)

Query: 298 SNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDN--CGITVHEGCYGVDG 355
           S++  + LE   + S ++M  I  CCVC  +     + ++ CD   C + VH+ CYG+  
Sbjct: 3   SSDRPVSLEDEVSHSMKEM--IGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGI-- 58

Query: 356 ESDSIMSSASENSTEPWFCDACKC---GVSPSCELCPNQDGIFKETDAGRWVHIVCALYV 412
                     +  T PWFC  C+         CELCP++DG  K TD G W H+VCALY+
Sbjct: 59  ---------VQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYI 109

Query: 413 PGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCED---PRFARTGVCISCDAGMCRAYFHV 469
           P V F ++  + P+ L  + + +Y  K C  C++      A TG C++C+   CR  FHV
Sbjct: 110 PEVQFANVSTMEPIVLQSVPHDRYN-KTCYICDEQGRESKAATGACMTCNKHGCRQAFHV 168

Query: 470 TCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQL 529
           TCAQ  GLL E          +  YCK H  +L +  +  N    QS    S   ++K  
Sbjct: 169 TCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHH 228

Query: 530 SPEAQ--ARINARLQQYRAKAELARSTRPQAWVPREK 564
             E +     +   Q+++ + E + +  P   V  EK
Sbjct: 229 EKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEK 265



 Score = 37.7 bits (86), Expect = 0.048
 Identities = 45/199 (22%), Positives = 69/199 (34%), Gaps = 45/199 (22%)

Query: 115 KEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATE 174
           K  EKEK+K KEK+K ++K K++   S  +  S   TT  T     N S S         
Sbjct: 226 KHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSIS--------- 276

Query: 175 EQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDG 234
                    +L+R        +     ++  + S              G+  S+  GS+G
Sbjct: 277 --------GSLKRLEDTTARFTNANFQEVSAHTS-------------SGKDVSETRGSEG 315

Query: 235 DNEDDEDEGSGSDEDE----NDEGNDEDHSSPASEGGCKKKKSKVLSRN----------- 279
             +      SG    +     + G     +SP  +G        V S +           
Sbjct: 316 KGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFL 375

Query: 280 SADDEELTNDSLTLSQSKS 298
           S  D +L NDS + SQ  S
Sbjct: 376 SFTDSDLRNDSYSHSQQSS 394



 Score = 33.5 bits (75), Expect = 0.90
 Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 5/93 (5%)

Query: 80  QLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKAT 139
           +LK S      S ++ L       ++++ E     KEK+K KEK+K K+K +++ +    
Sbjct: 200 KLKKSKRGSNRSYDQSLSDSSSHSQDKHHE-----KEKKKYKEKDKHKQKHKKQPEPSPA 254

Query: 140 VSENVAASAAATTPATSPPAVNTSPSVPTTTTA 172
           +  ++  +   T  +TS  +++ S      TTA
Sbjct: 255 LVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTA 287


>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 6 [Homo sapiens]
          Length = 1093

 Score =  134 bits (337), Expect = 4e-31
 Identities = 67/189 (35%), Positives = 96/189 (50%), Gaps = 20/189 (10%)

Query: 322 CCVCLGDNSEDADEIIQCDN--CGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKC 379
           CCVC  +     + ++ CD   C + VH+ CYG+            +  T PWFC  C+ 
Sbjct: 8   CCVCSDERGWAENPLVYCDGHACSVAVHQACYGI-----------VQVPTGPWFCRKCES 56

Query: 380 ---GVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKY 436
                   CELCP++DG  K TD G W H+VCALY+P V F ++  + P+ L  + + ++
Sbjct: 57  QERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRF 116

Query: 437 GAKECSFCED---PRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFA 493
             K C  CE+      A +G C++C+   CR  FHVTCAQ  GLL E    E     +  
Sbjct: 117 N-KTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCG 175

Query: 494 YCKQHADRL 502
           YCK H  ++
Sbjct: 176 YCKYHFSKM 184


>gi|40556393 PHD finger protein 17 long isoform [Homo sapiens]
          Length = 842

 Score =  132 bits (333), Expect = 1e-30
 Identities = 100/361 (27%), Positives = 154/361 (42%), Gaps = 62/361 (17%)

Query: 317 DHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDA 376
           D  ++C VC   + ED +E++ CD C I VH+ CYG+            E S   W C  
Sbjct: 201 DEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGI--------LKVPEGS---WLCRT 249

Query: 377 CKCGVSPSCELCPNQDGIFKETDAG-RWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSK 435
           C  GV P C LCP + G  K T +G +WVH+ CAL++P V+ G  +K+ P+T      S 
Sbjct: 250 CALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSS 309

Query: 436 YGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYC 495
             A  CS C +    + G  I C    CR  FHVTCA   GL  +    E+    F +YC
Sbjct: 310 RWALVCSLCNE----KFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYC 365

Query: 496 KQHADRLDRKWKRKNYLALQSYCKMSLQER-EKQLSPEAQARINARLQQYRAKAELARST 554
            +H+     +         +S  K + QE    + SP       A L+Q R +A      
Sbjct: 366 PKHSSHRKPE---------ESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAH----- 411

Query: 555 RPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPA 614
                                 R  +RK +L  +  + +   N      +D  R  + P 
Sbjct: 412 ----------------------RVSVRKQKLQQLEDEFYTFVN-----LLDVARALRLPE 444

Query: 615 LTADFVNYYFERNMRMIQIQENMAEQKNIKDKL-ENEQEKLHVE---YNKLCESLEELQN 670
              DF+  Y++   ++   +  +  +K+ +D L + EQ+ L      +  L + LE ++N
Sbjct: 445 EVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRN 504

Query: 671 L 671
           L
Sbjct: 505 L 505


>gi|40556370 PHD finger protein 15 [Homo sapiens]
          Length = 790

 Score =  132 bits (331), Expect = 2e-30
 Identities = 70/219 (31%), Positives = 106/219 (48%), Gaps = 22/219 (10%)

Query: 289 DSLTLSQSKSNEDSLILE------KSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNC 342
           D LTL +     ++L  +      ++Q     + D  ++C VC     ED +E++ CD C
Sbjct: 163 DELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKC 222

Query: 343 GITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAG- 401
            + VH+ CYG+            +  T  W C  C  GV P C LCP + G  K T +G 
Sbjct: 223 NVCVHQACYGI-----------LKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGT 271

Query: 402 RWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAG 461
           +WVH+ CAL++P V+ G  +K+ P+T      +   A  CS C++     TG CI C   
Sbjct: 272 KWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKE----CTGTCIQCSMP 327

Query: 462 MCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHAD 500
            C   FHVTCA   GL       ++    F ++C++H+D
Sbjct: 328 SCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSD 366


>gi|19923609 PHD finger protein 17 short isoform [Homo sapiens]
          Length = 509

 Score =  131 bits (329), Expect = 3e-30
 Identities = 67/184 (36%), Positives = 92/184 (50%), Gaps = 16/184 (8%)

Query: 317 DHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDA 376
           D  ++C VC   + ED +E++ CD C I VH+ CYG+            E S   W C  
Sbjct: 201 DEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGI--------LKVPEGS---WLCRT 249

Query: 377 CKCGVSPSCELCPNQDGIFKETDAG-RWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSK 435
           C  GV P C LCP + G  K T +G +WVH+ CAL++P V+ G  +K+ P+T      S 
Sbjct: 250 CALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSS 309

Query: 436 YGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYC 495
             A  CS C +    + G  I C    CR  FHVTCA   GL  +    E+    F +YC
Sbjct: 310 RWALVCSLCNE----KFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYC 365

Query: 496 KQHA 499
            +H+
Sbjct: 366 PKHS 369


>gi|117190334 PHD finger protein 16 [Homo sapiens]
          Length = 823

 Score =  127 bits (319), Expect = 5e-29
 Identities = 95/390 (24%), Positives = 167/390 (42%), Gaps = 46/390 (11%)

Query: 283 DEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNC 342
           DE L   ++ + +   +E+     +++     + D  +IC VC   +SE+ ++++ CD C
Sbjct: 164 DENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKC 223

Query: 343 GITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAG- 401
            + VH+ CYG+            E S   W C +C  G+ P C LCP + G  K T  G 
Sbjct: 224 NVCVHQACYGI--------LKVPEGS---WLCRSCVLGIYPQCVLCPKKGGALKTTKTGT 272

Query: 402 RWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAG 461
           +W H+ CAL++P V+    +++ P+T          A  C+ C+     +TG CI C   
Sbjct: 273 KWAHVSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCK----LKTGACIQCSIK 328

Query: 462 MCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMS 521
            C   FHVTCA + GL  +   +E     F +YC +H+       + +  L    Y    
Sbjct: 329 SCITAFHVTCAFEHGLEMKTILDEGDEVKFKSYCLKHS-------QNRQKLGEAEY---- 377

Query: 522 LQEREKQLSPEAQARINARLQQYR-AKAELARSTRPQAWVPREKLPRPLTSSASAIRKLM 580
              R K+ S     + + R Q+ R  + E     R +       +P           KL 
Sbjct: 378 PHHRAKEQSQAKSEKTSLRAQKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLK 437

Query: 581 RKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRM-IQIQENMAE 639
           RK+     +  +FP    + +  V  + +                  MRM + +++++  
Sbjct: 438 RKS---NFNKPLFPPKEDEENGLVQPKEES-------------IHTRMRMFMHLRQDLER 481

Query: 640 QKNIKDKLENEQEKLHVEYNKLCESLEELQ 669
            +N+   + + +EKL + +NK+ E +  LQ
Sbjct: 482 VRNLCYMI-SRREKLKLSHNKIQEQIFGLQ 510


>gi|7662006 PHD finger protein 16 [Homo sapiens]
          Length = 823

 Score =  127 bits (319), Expect = 5e-29
 Identities = 95/390 (24%), Positives = 167/390 (42%), Gaps = 46/390 (11%)

Query: 283 DEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNC 342
           DE L   ++ + +   +E+     +++     + D  +IC VC   +SE+ ++++ CD C
Sbjct: 164 DENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKC 223

Query: 343 GITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAG- 401
            + VH+ CYG+            E S   W C +C  G+ P C LCP + G  K T  G 
Sbjct: 224 NVCVHQACYGI--------LKVPEGS---WLCRSCVLGIYPQCVLCPKKGGALKTTKTGT 272

Query: 402 RWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAG 461
           +W H+ CAL++P V+    +++ P+T          A  C+ C+     +TG CI C   
Sbjct: 273 KWAHVSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCK----LKTGACIQCSIK 328

Query: 462 MCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMS 521
            C   FHVTCA + GL  +   +E     F +YC +H+       + +  L    Y    
Sbjct: 329 SCITAFHVTCAFEHGLEMKTILDEGDEVKFKSYCLKHS-------QNRQKLGEAEY---- 377

Query: 522 LQEREKQLSPEAQARINARLQQYR-AKAELARSTRPQAWVPREKLPRPLTSSASAIRKLM 580
              R K+ S     + + R Q+ R  + E     R +       +P           KL 
Sbjct: 378 PHHRAKEQSQAKSEKTSLRAQKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLK 437

Query: 581 RKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRM-IQIQENMAE 639
           RK+     +  +FP    + +  V  + +                  MRM + +++++  
Sbjct: 438 RKS---NFNKPLFPPKEDEENGLVQPKEES-------------IHTRMRMFMHLRQDLER 481

Query: 640 QKNIKDKLENEQEKLHVEYNKLCESLEELQ 669
            +N+   + + +EKL + +NK+ E +  LQ
Sbjct: 482 VRNLCYMI-SRREKLKLSHNKIQEQIFGLQ 510


>gi|51173722 bromodomain and PHD finger-containing protein 1 isoform
           2 [Homo sapiens]
          Length = 1214

 Score =  114 bits (286), Expect = 3e-25
 Identities = 60/166 (36%), Positives = 82/166 (49%), Gaps = 20/166 (12%)

Query: 316 MDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCD 375
           +D   +CC+C     ++++ I+ CD C + VH+ CYGV    +             W C 
Sbjct: 270 VDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEG-----------QWLCR 318

Query: 376 ACKCGVSPS----CELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEM 431
             +C  SPS    C LCPN+ G FK+TD GRW H+VCAL++P V F +   L P+   E 
Sbjct: 319 --RCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEH 376

Query: 432 NYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGL 477
                    C  C+      +G CI C    C   FHVTCAQ+ GL
Sbjct: 377 IPPARWKLTCYICKQ---RGSGACIQCHKANCYTAFHVTCAQQAGL 419


>gi|51173720 bromodomain and PHD finger-containing protein 1 isoform
           1 [Homo sapiens]
          Length = 1220

 Score =  114 bits (286), Expect = 3e-25
 Identities = 60/166 (36%), Positives = 82/166 (49%), Gaps = 20/166 (12%)

Query: 316 MDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCD 375
           +D   +CC+C     ++++ I+ CD C + VH+ CYGV    +             W C 
Sbjct: 270 VDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEG-----------QWLCR 318

Query: 376 ACKCGVSPS----CELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEM 431
             +C  SPS    C LCPN+ G FK+TD GRW H+VCAL++P V F +   L P+   E 
Sbjct: 319 --RCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEH 376

Query: 432 NYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEGL 477
                    C  C+      +G CI C    C   FHVTCAQ+ GL
Sbjct: 377 IPPARWKLTCYICKQ---RGSGACIQCHKANCYTAFHVTCAQQAGL 419


>gi|148727368 bromodomain and PHD finger containing, 3 [Homo
           sapiens]
          Length = 1205

 Score =  114 bits (284), Expect = 5e-25
 Identities = 69/222 (31%), Positives = 97/222 (43%), Gaps = 27/222 (12%)

Query: 289 DSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHE 348
           D+  L   +  ++S +  +S       +D    CCVCL D   +++ I+ CD C + VH+
Sbjct: 182 DTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQ 241

Query: 349 GCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPS----CELCPNQDGIFKETDAGRWV 404
            CYGV    +             W C  C    SPS    C LCPN+ G FK+T  G W 
Sbjct: 242 ECYGVPYIPEG-----------QWLCRCCL--QSPSRPVDCILCPNKGGAFKQTSDGHWA 288

Query: 405 HIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCR 464
           H+VCA+++P V F +   L P+   +          C  C+       G  I C    C 
Sbjct: 289 HVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGL---GAAIQCHKVNCY 345

Query: 465 AYFHVTCAQKEGLLS--EAAAEEDIADPFF-----AYCKQHA 499
             FHVTCAQ+ GL    E   E  +    F     AYC+ H+
Sbjct: 346 TAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHS 387



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 17/132 (12%)

Query: 656 VEYNKLCESLEELQNLNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGT 715
           VEY+   E L  L  +N K R +G    +L+   T + L    + R  KE     +  G 
Sbjct: 152 VEYDMDEEDLAWLDMVNEKRRVDGH---SLVSADTFELL----VDRLEKESYLESRSSGA 204

Query: 716 QKTSTLPAVLYSCGICKKN--HDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQC 773
           Q+ S +    + C +C  +  H+ +++L CD C L  H  C   P            W C
Sbjct: 205 QQ-SLIDEDAFCC-VCLDDECHNSNVILFCDICNLAVHQECYGVPY------IPEGQWLC 256

Query: 774 SECDQAGSSDME 785
             C Q+ S  ++
Sbjct: 257 RCCLQSPSRPVD 268


>gi|11321642 bromodomain containing protein 1 [Homo sapiens]
          Length = 1058

 Score =  109 bits (272), Expect = 1e-23
 Identities = 60/181 (33%), Positives = 85/181 (46%), Gaps = 23/181 (12%)

Query: 306 EKSQNWSSQK-------MDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESD 358
           EK  +  +QK       +D   +CC+C+    ++++ I+ CD C + VH+ CYGV    +
Sbjct: 194 EKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPE 253

Query: 359 SIMSSASENSTEPWFCDAC-KCGVSPS-CELCPNQDGIFKETDAGRWVHIVCALYVPGVA 416
                        W C  C +    P+ C LCPN+ G FK+TD  RW H+VCAL++P V 
Sbjct: 254 G-----------QWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVG 302

Query: 417 FGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQKEG 476
           F +   + P+              C  C+       G CI C    C   FHVTCAQK G
Sbjct: 303 FANTVFIEPIDGVRNIPPARWKLTCYLCKQ---KGVGACIQCHKANCYTAFHVTCAQKAG 359

Query: 477 L 477
           L
Sbjct: 360 L 360


>gi|98986459 jumonji domain containing 2A [Homo sapiens]
          Length = 1064

 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 47/164 (28%), Positives = 75/164 (45%), Gaps = 15/164 (9%)

Query: 336 IIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCG-VSPSCELCPNQDGI 394
           ++ C  C + VH  CYGV              ++E W C  C    +   C LC  + G 
Sbjct: 735 LVSCKKCSVRVHASCYGVP----------PAKASEDWMCSRCSANALEEDCCLCSLRGGA 784

Query: 395 FKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGV 454
            +  +  RWVH+ CA+ +    F +I +  PV ++++   ++  K C FC+  R    G 
Sbjct: 785 LQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLK-CIFCKKRRKRTAGC 843

Query: 455 CISCDAGMCRAYFHVTCAQKEGLLSEAAAEEDIADPFFAYCKQH 498
           C+ C  G C   FHV+CAQ  G++ +    +D     F  C +H
Sbjct: 844 CVQCSHGRCPTAFHVSCAQAAGVMMQ---PDDWPFVVFITCFRH 884


>gi|226442889 jumonji domain containing 2C isoform 2 [Homo sapiens]
          Length = 1047

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 47/146 (32%), Positives = 67/146 (45%), Gaps = 12/146 (8%)

Query: 336 IIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGV-SPSCELCPNQDGI 394
           +I C  C + VH  CYG+           S    + W C  CK    +  C LC  + G 
Sbjct: 715 LISCAKCCVRVHASCYGIP----------SHEICDGWLCARCKRNAWTAECCLCNLRGGA 764

Query: 395 FKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGV 454
            K+T   +W H++CA+ VP V F ++ +   + +  +   +   K C FC       +G 
Sbjct: 765 LKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLK-CIFCRHRVKRVSGA 823

Query: 455 CISCDAGMCRAYFHVTCAQKEGLLSE 480
           CI C  G C A FHVTCA   G+L E
Sbjct: 824 CIQCSYGRCPASFHVTCAHAAGVLME 849


>gi|109255247 jumonji domain containing 2C isoform 1 [Homo sapiens]
          Length = 1056

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 47/146 (32%), Positives = 67/146 (45%), Gaps = 12/146 (8%)

Query: 336 IIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGV-SPSCELCPNQDGI 394
           +I C  C + VH  CYG+           S    + W C  CK    +  C LC  + G 
Sbjct: 715 LISCAKCCVRVHASCYGIP----------SHEICDGWLCARCKRNAWTAECCLCNLRGGA 764

Query: 395 FKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGV 454
            K+T   +W H++CA+ VP V F ++ +   + +  +   +   K C FC       +G 
Sbjct: 765 LKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLK-CIFCRHRVKRVSGA 823

Query: 455 CISCDAGMCRAYFHVTCAQKEGLLSE 480
           CI C  G C A FHVTCA   G+L E
Sbjct: 824 CIQCSYGRCPASFHVTCAHAAGVLME 849


>gi|45504380 jumonji domain containing 2B [Homo sapiens]
          Length = 1096

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 47/156 (30%), Positives = 70/156 (44%), Gaps = 14/156 (8%)

Query: 326 LGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGV-SPS 384
           +GD+      +I C  C + VH  CYG+            E   E W C  C     +  
Sbjct: 749 IGDDG--TSPLIACGKCCLQVHASCYGI----------RPELVNEGWTCSRCAAHAWTAE 796

Query: 385 CELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFC 444
           C LC  + G  + T   RW+H++CA+ VP   F ++ +  PV ++ +   ++  K C +C
Sbjct: 797 CCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLK-CVYC 855

Query: 445 EDPRFARTGVCISCDAGMCRAYFHVTCAQKEGLLSE 480
                  +G CI C    C   FHVTCA   G+L E
Sbjct: 856 RKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLME 891


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 77/369 (20%), Positives = 135/369 (36%), Gaps = 35/369 (9%)

Query: 4   SSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDA-SKDSGEGSCSDSE 62
           SSK       + S  ++ D +SSD SD    D+SDS  S N S+ + S DS + S S   
Sbjct: 626 SSKSESDSSDSDSKSDSSDSNSSDSSDNS--DSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683

Query: 63  ENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKE 122
            N  +   + D     E   +S   +  SS+           + +        +     +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS-DSSNSNSSDSDSSNSSDSSDSSNSSD 742

Query: 123 KEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKK 182
                +     +   ++ S N + S+ ++  + S  + N+S S  ++ ++     S    
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSN--- 799

Query: 183 WNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDE 242
                        S +  N  D  DS D +D           S S    +  D+ D  + 
Sbjct: 800 -------------SSDSSNSSDSSDSSDSSD--------SDSSNSSDSSNSSDSSDSSNS 838

Query: 243 GSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDS 302
              SD  ++ +G+D D S+ +             S NS+D  + ++ + + + S S++ S
Sbjct: 839 SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898

Query: 303 LILEKSQNWSSQKMDHILICCVCLGDNSEDADEII-QCDNCGITVHEGCYGVDGESDSIM 361
              +   + SS   D           NS D+ E     DN   +           SDS  
Sbjct: 899 NSSDSDSSDSSNSSDS------SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952

Query: 362 SSASENSTE 370
           SS S NS++
Sbjct: 953 SSDSSNSSD 961



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 66/350 (18%), Positives = 138/350 (39%), Gaps = 9/350 (2%)

Query: 24  DSSDDSDFKVG--DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQL 81
           D +D SD   G  D+SDS+ S + +   S DS +   SDS  +   +  + D     +  
Sbjct: 535 DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594

Query: 82  KNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVS 141
            + +     SS+      +  +  ++ +    K +  K +    + + + +     ++ S
Sbjct: 595 SSDSSNSSDSSDSS----DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650

Query: 142 ENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELN 201
            + + S+ ++  + S  + ++S S  +++++     S+    +   N    +     + +
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS--ESSDSSDSS 708

Query: 202 DMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSS 261
           D D  DS D ++   +       S S    +  D+ D  D  + SD  ++ + ++   SS
Sbjct: 709 DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768

Query: 262 PASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSL-ILEKSQNWSSQKMDHIL 320
            +S+       S     N + +   ++DS   S S ++ DS    + S + SS   D   
Sbjct: 769 DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSN 828

Query: 321 ICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                   NS D+ +     +   +           SDS  SS S NS++
Sbjct: 829 SSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSD 878



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 69/350 (19%), Positives = 129/350 (36%), Gaps = 12/350 (3%)

Query: 24   DSSDDSDFKVGDASDSEGSGNGSEDA-SKDSGEGSCSDSEENILEEELNEDIKVKEEQLK 82
            DSSD S+    D+SDS  S + S+ + S DS E S S    N  +   + D     +   
Sbjct: 893  DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS-S 951

Query: 83   NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSE 142
            NS++    S              ++ +        +     +     +     + +  S+
Sbjct: 952  NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011

Query: 143  NVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELND 202
            + + S+ ++  + S  + N+S S  ++ ++     S+    +   N       S +  + 
Sbjct: 1012 S-SDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN-------SSDSSDS 1063

Query: 203  MDDYDSEDDNDWRPTVVKRKGRSASQKEGS--DGDNEDDEDEGSGSDEDENDEGNDEDHS 260
             D  DS D +D   +    +   +S    S    D+ D  D    SD  ++ + +D  +S
Sbjct: 1064 SDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1123

Query: 261  SPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHIL 320
            S +S+       S   + + + D   ++DS   S S  + DS     S + S        
Sbjct: 1124 SDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183

Query: 321  ICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                   D+S+ +D     D+   +           SDS  SS S +S E
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNE 1233



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 70/349 (20%), Positives = 129/349 (36%), Gaps = 20/349 (5%)

Query: 24   DSSDDSDFKVGDASDSEGSGNGSE--DASKDSGEGSCSDSEENILEEELNEDIKVKEEQL 81
            DSSD SD    D+S+   S N S+  D+S  S     SDS ++      ++         
Sbjct: 843  DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD 902

Query: 82   KNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVS 141
             +S++    S            E  N        +     +     +     +   ++ S
Sbjct: 903  SDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS 962

Query: 142  ENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELN 201
             N ++ ++ +  + S  + N+S S  ++ ++     S+    N   +    D  S +  N
Sbjct: 963  SN-SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS--NSSDSSDSSD--SSDSSN 1017

Query: 202  DMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSS 261
              D  +S D ++   +       S S       D+ D  D  + SD  ++ + +D   SS
Sbjct: 1018 SSDSSNSSDSSNSSDS----SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073

Query: 262  PASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILI 321
             +S+     + S     +++ D   ++DS   S S  + DS     S N SS   D    
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSN-SSDSSDS--- 1129

Query: 322  CCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                  D+S+ +D     D+   +           SDS  SS S +S++
Sbjct: 1130 -----SDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 78/360 (21%), Positives = 135/360 (37%), Gaps = 37/360 (10%)

Query: 24   DSSDDSDFKVG----DASDSEGSGNGSEDA-SKDSGEGSCSDSEENILEEELNEDIKVKE 78
            DSSD SD        ++SDS  S + S  + S DS + S SDS ++             +
Sbjct: 670  DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS------------SD 717

Query: 79   EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
                NS++ +  +S          +  ++ +      +     +     +     +   +
Sbjct: 718  SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSD-SSNSSDSSDSSDSSNSSDSSDSSDSSDS 776

Query: 139  TVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSME 198
            + S N + S  ++  + S  + N+S S  ++ ++     S+    N   +    D  S +
Sbjct: 777  SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD--SSD 834

Query: 199  ELNDMDDYDSEDDNDWRPTVVKRK---GRSASQKEGSDGDNEDDEDEGSGSDEDEN-DEG 254
              N  D  DS D +D   +    +     S+   + SD  N  D  + S S+E  N  + 
Sbjct: 835  SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894

Query: 255  NDEDHSSPASEGGCKKKKSKVLSRNSADDEELTN--DSLTLSQSKSNEDSLILEKSQNW- 311
            +D  +SS +             S NS+D  E +N  D+   S S ++ DS     S N  
Sbjct: 895  SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS 954

Query: 312  -SSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
             SS   D           NS D+ +    D+   +           SDS  SS S NS++
Sbjct: 955  DSSNSSD---------SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 70/356 (19%), Positives = 136/356 (38%), Gaps = 28/356 (7%)

Query: 24  DSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKN 83
           + +DD++ +  + S S G  + + D SKD+G GS S   E+   +  ++          N
Sbjct: 472 NGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGN 531

Query: 84  SAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSEN 143
           +  ++   S+        K + ++ +          +     + +         +  S++
Sbjct: 532 NGNDDNDKSD------SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585

Query: 144 VAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDM 203
            ++ ++ +  + S  + ++S S  ++ ++     S+ K  + +      D  S  + +D 
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645

Query: 204 DDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPA 263
           +  DS D++D           S S       D+ D  D  S SD   + + +D   SS +
Sbjct: 646 NSSDSSDNSD-------SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698

Query: 264 SEGGCKKKKSKVLSRNSAD---------DEELTNDSLTLSQSKSNEDSLILEKSQNWSSQ 314
           SE       S   S +S+D         D   ++DS   S S  + DS     S + SS 
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD-SSD 757

Query: 315 KMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
             D          D+S+ +D     D+   +           SDS  SS S NS++
Sbjct: 758 SSD-----SSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD 808



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 68/354 (19%), Positives = 137/354 (38%), Gaps = 13/354 (3%)

Query: 19  EALDYDSSDDSDFKV---GDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIK 75
           ++ D   SD SD       D+SDS+ S +   D+S  S     SDS ++    + ++   
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621

Query: 76  VKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEK 135
            K +  K+ ++     S+         +  +N +              +     +     
Sbjct: 622 SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681

Query: 136 EKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFV 195
           + +  S++  +S ++ +  +S  + ++      ++ ++    S+    N   +    +  
Sbjct: 682 DSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS 741

Query: 196 SMEELND-MDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEG 254
              + +D  +  DS D +D   +       S+   + SD  N  D ++ S S  D +D  
Sbjct: 742 DSSDSSDSSNSSDSSDSSD--SSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS-SDSSDSS 798

Query: 255 NDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQ 314
           N  D SS +S+       S   S NS+D    ++ S + + S S++ S   + S + SS 
Sbjct: 799 NSSD-SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSN 857

Query: 315 KMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENS 368
           + D          D+S+ +D     D+   +           SDS  SS S++S
Sbjct: 858 RSD-----SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 68/348 (19%), Positives = 128/348 (36%), Gaps = 27/348 (7%)

Query: 24   DSSDDSDFKVGDASDS-EGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLK 82
            DSS+ SD    D+SDS +GS + S + S  S     SDS ++    + ++     E    
Sbjct: 834  DSSNSSDSS--DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891

Query: 83   NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSE 142
            + + +   SS+          +  N              E     +     +   ++ S 
Sbjct: 892  SDSSDSSNSSDSD------SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945

Query: 143  NVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELND 202
            + + S+ ++  + S  + N+S S  + ++ + +  +     +   +    D  S +  N 
Sbjct: 946  DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD--SSDSSNS 1003

Query: 203  MDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSP 262
             D  DS D +D           S S    +  D+ D  D    SD  ++ + +D  +SS 
Sbjct: 1004 SDSSDSSDSSD----SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1059

Query: 263  ASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILIC 322
            +S+       S     + + D   ++DS   S S  + DS     S + S          
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS-------- 1111

Query: 323  CVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                 D+S+ +D     D+   +           SDS  SS S +S++
Sbjct: 1112 ----SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSD 1155



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 75/351 (21%), Positives = 126/351 (35%), Gaps = 44/351 (12%)

Query: 24   DSSDDSDF-KVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILE--EELNEDIKVKEEQ 80
            DSSD SD  +  ++SDS  S N S+  S DS   S S    N  +  E  N         
Sbjct: 878  DSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSD 937

Query: 81   LKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATV 140
              NS++    S            +  N          +           +     + +  
Sbjct: 938  SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997

Query: 141  SENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEEL 200
            S++ + S+ ++  + S  + N+S S  ++ ++     S+                S +  
Sbjct: 998  SDS-SNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD----------------SSDSS 1040

Query: 201  NDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDG-DNEDDEDEGSGSDEDENDEGNDEDH 259
            +  D  DS D +D           S+   + SD  D+ D  D    SD  E+ + +D  +
Sbjct: 1041 DSSDSSDSSDSSD--------SSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092

Query: 260  SSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHI 319
            SS +S+       S   S +S+D  + ++DS   S S  + DS     S N S       
Sbjct: 1093 SSDSSDSSDSSDSSD--SSDSSDSSD-SSDSSNSSDSSDSSDSSDSSDSSNSSDS----- 1144

Query: 320  LICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                    D+SE +D     D+   +           SDS  SS S +S++
Sbjct: 1145 -------SDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/351 (21%), Positives = 135/351 (38%), Gaps = 49/351 (13%)

Query: 23  YDSSDDSDFKV-GDASDS--EGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEE 79
           YDS D  D  + GD  +S  E +GN   ++  D+   S  D+  N  E + N +      
Sbjct: 450 YDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGN-----G 504

Query: 80  QLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKAT 139
                AE++   S       +      NG     K +  K K    + +     +   ++
Sbjct: 505 SDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSD---SSDSSNSS 561

Query: 140 VSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEE 199
            S + + S ++ + ++S    + S S  ++ + + +                    S   
Sbjct: 562 DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSD--------------------SSNS 601

Query: 200 LNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDH 259
            +  D  DS D +D   +   +   S S+ + SD D++ D  + + SD  +N + +D  +
Sbjct: 602 SDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN 661

Query: 260 SSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHI 319
           SS +S+       S   S +S+D    ++ S +   S S+E S   + S + SS   D  
Sbjct: 662 SSNSSDSSDSSDSSD--SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD-- 717

Query: 320 LICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
                    NS D+D     D+   +           SDS  SS S NS++
Sbjct: 718 -----SSNSNSSDSDSSNSSDSSDSS---------NSSDSSDSSDSSNSSD 754



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 71/347 (20%), Positives = 124/347 (35%), Gaps = 52/347 (14%)

Query: 24   DSSDDSDFKVGDASDSEGSGNGSEDA-SKDSGEGSCSDSEENILEEELNEDIKVKEEQLK 82
            DSSD SD    D+SDS  S N S+ + S DS + S S    N  +   + D     +   
Sbjct: 984  DSSDSSDSS--DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 83   NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSE 142
            +S   +   S           +  N        +     +     +     E   ++ S 
Sbjct: 1042 SSDSSDSSDSS----------DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS 1091

Query: 143  NVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELND 202
            N + S+ ++  + S  + ++S S  ++ ++     S+                S +  + 
Sbjct: 1092 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD----------------SSDSSDS 1135

Query: 203  MDDYDSEDDNDWRPTVVKRKGRSASQKEGSD-GDNEDDEDEGSGSDEDENDEGNDEDHSS 261
             D  +S D +D           S+   + SD  D+ D  D    SD  ++   +D   SS
Sbjct: 1136 SDSSNSSDSSD--------SSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1187

Query: 262  PASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILI 321
             +S+       S     + + D   ++DS   S S  + DS    +S + SS   D    
Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSD-SSDSSDS--- 1243

Query: 322  CCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENS 368
                  D+S  +D     D+   T        + ESDS   S + N+
Sbjct: 1244 -----SDSSNSSDSSDSSDSSDSTSDS-----NDESDSQSKSGNGNN 1280



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 90/397 (22%), Positives = 145/397 (36%), Gaps = 63/397 (15%)

Query: 22  DYDSSDDSDFKVGDASDS-------EGSGNGSEDASKDSGEGSCSDSEENILEEELNEDI 74
           D  S DD D + G+  DS       EG  +G ED   DS  G  SDS+E   + E  ED 
Sbjct: 256 DEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKED-DHDSSIGQNSDSKE-YYDPEGKEDP 313

Query: 75  KVKEEQLKNSAEEEVLS-----SEKQLIKMEKKEEEENGERPRKKKEKEKE--------- 120
             + +  K S  EE  +     +  Q I+  +K      +R   +  KE E         
Sbjct: 314 HNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQD 373

Query: 121 ----------------KEKEKEKEKEREKEKEKATVSE-NVAASAAATTPATSPPAVNTS 163
                           KE  K  E + +K +    + + NV                   
Sbjct: 374 KGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPG 433

Query: 164 PSVPTTTTATEEQVSEPKKWNL-RRNRPLLDFVSMEELNDMDDYDSEDDND--WRPTVVK 220
             V  + T ++        ++   ++    D  S +E N  DD +SE DN+   R     
Sbjct: 434 NKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASY 493

Query: 221 RKGRSASQKEGSDGDNEDDEDEGSGSDEDEND------EGNDEDHSSPASEGGCKKKKSK 274
               S     GSD    +D+D  S SD + +D       GND++  S + +G      S 
Sbjct: 494 NSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSD 553

Query: 275 VL-SRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDA 333
              S NS+D  + ++   + S S S+ DS   + S +  S   D          ++S+ +
Sbjct: 554 SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS--------SNSSDSS 605

Query: 334 DEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTE 370
           D     D+      +     D +SDS  S +  + ++
Sbjct: 606 DSSDSSDS-----SDSSDSSDSKSDSSKSESDSSDSD 637



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 49/272 (18%), Positives = 100/272 (36%), Gaps = 23/272 (8%)

Query: 24   DSSDDSDFK----VGDASDSEGSGNGSEDA-SKDSGEGSCSDSEENILEEELNEDIKVKE 78
            DSSD SD        D+SDS  S + S+ + S DS E S S    N  +   + D     
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106

Query: 79   EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
            +   +S   +   S       +  +  ++ +        +  +  +     +     + +
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSS 1166

Query: 139  TVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSME 198
              S++ + S+ ++  + S  + ++S S  ++ ++     S+                S +
Sbjct: 1167 DSSDS-SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD----------------SSD 1209

Query: 199  ELNDMDDYDSEDDNDWRPTVVKRKGR-SASQKEGSDGDNEDDEDEGSGSDEDENDEGNDE 257
              +  D  DS D +D   +    +   S+   + SD  N  D  + S S +  +D  ++ 
Sbjct: 1210 SSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDES 1269

Query: 258  DHSSPASEGGCKKKKSKVLSRNSADDEELTND 289
            D  S +  G      S   S  S  +   ++D
Sbjct: 1270 DSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 1/81 (1%)

Query: 204 DDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPA 263
           +D  S DD D      K    ++  +EG D   EDD D   G + D  +  + E    P 
Sbjct: 255 EDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPH 314

Query: 264 SE-GGCKKKKSKVLSRNSADD 283
           +E  G K  KS+  S    +D
Sbjct: 315 NEVDGDKTSKSEENSAGIPED 335



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 19/40 (47%), Positives = 24/40 (60%), Gaps = 3/40 (7%)

Query: 230 EGSDGDN--EDDEDEGSGSDEDEN-DEGNDEDHSSPASEG 266
           +GS   N  ++DEDEGSG DEDE    G D  ++S   EG
Sbjct: 243 DGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEG 282



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 29/124 (23%)

Query: 210 DDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDEN-------DEGNDEDHSSP 262
           D++D  P+     G  A + E     +++DE+ G+G D   N       D G ++DH S 
Sbjct: 240 DNSDGSPS-----GNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSS 294

Query: 263 ASEGGCKKK----KSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQN----WSSQ 314
             +    K+    + K    N  D ++          SKS E+S  + +         +Q
Sbjct: 295 IGQNSDSKEYYDPEGKEDPHNEVDGDK---------TSKSEENSAGIPEDNGSQRIEDTQ 345

Query: 315 KMDH 318
           K++H
Sbjct: 346 KLNH 349



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 68/349 (19%), Positives = 135/349 (38%), Gaps = 54/349 (15%)

Query: 32  KVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLS 91
           K     ++E +    EDA  D+ +GS S    N  +E+ +E     E++   + ++   +
Sbjct: 220 KRNGTKEAEVTPGTGEDAGLDNSDGSPSG---NGADEDEDEGSGDDEDEEAGNGKDSSNN 276

Query: 92  SEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAAT 151
           S+ Q  +   KE++ +    +    KE    + KE +   E + +K + SE  +A     
Sbjct: 277 SKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKE-DPHNEVDGDKTSKSEENSAGI--- 332

Query: 152 TPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDD 211
                 P  N S           +++ + +K N R ++ + + ++ E  ++        D
Sbjct: 333 ------PEDNGS-----------QRIEDTQKLNHRESKRVENRITKE--SETHAVGKSQD 373

Query: 212 NDWRPTVVKRKGRSASQKEGSDGDNEDDEDE-----GSGSDEDENDEGNDEDHSSPASEG 266
                       R+ +++ G   + ++D+ +     G G+ + + +  N E      SE 
Sbjct: 374 KGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEG-PGQKSEP 432

Query: 267 GCKKKKSKVLSRNSA--------DDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDH 318
           G K   S   S +++        DD+ +  D    S   +  D    E   N SS+    
Sbjct: 433 GNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSR---- 488

Query: 319 ILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASEN 367
                   GD S ++DE    DN   +  +G    D +S S  +++  N
Sbjct: 489 --------GDASYNSDE--SKDNGNGSDSKGAEDDDSDSTSDTNNSDSN 527


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 81/342 (23%), Positives = 153/342 (44%), Gaps = 55/342 (16%)

Query: 24  DSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKN 83
           +  ++ D K  D    +G     E+  K+  +G  S +    ++E L + +K +EE+ K 
Sbjct: 306 EDDNEGDKKKKDKKKKKGE---KEEKEKEKKKGP-SKATVKAMQEALAK-LKEEEERQKR 360

Query: 84  SAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSEN 143
             EE +    K+L ++E K +EE  ER  ++K +E++K+KEKE+++  +KE +  T S+ 
Sbjct: 361 EEEERI----KRLEELEAKRKEE--ERLEQEK-RERKKQKEKERKERLKKEGKLLTKSQR 413

Query: 144 VA-ASAAATTPATSPPAVN--TSPSVPTTTTATEEQVSE--PKKWNLRRNRPLLDFVSME 198
            A A A AT        V   +  S+P      E++  +  P++   +     ++  +  
Sbjct: 414 EARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAV 473

Query: 199 ELNDM---------------DDYDSEDD--NDWRPTV----------------VKRKGRS 225
           E+ +                ++ D+ED   +DW                    VK     
Sbjct: 474 EVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE 533

Query: 226 ASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHS-SPASEGG--CKKKKSKVLSRNSA- 281
             ++E  + ++E+ E+E     E E  EG++ED   S   + G    KK SK +S +S  
Sbjct: 534 EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY 593

Query: 282 -DDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILIC 322
             D++ T +     ++K   +   LE S+N +++K+   +IC
Sbjct: 594 DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIIC 635



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 53/244 (21%), Positives = 98/244 (40%), Gaps = 37/244 (15%)

Query: 78  EEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEK 137
           E+  K+  + + L++E +     K++E +     + K +K+KEK+K+   E +  KE E+
Sbjct: 10  EDSTKDDIDLDALAAEIEGAGAAKEQEPQ-----KSKGKKKKEKKKQDFDEDDILKELEE 64

Query: 138 ATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSM 197
            ++ E     A   T A            PT     E    + KK   +  +   D    
Sbjct: 65  LSL-EAQGIKADRETVAVK----------PTENNEEEFTSKDKKKKGQKGKKQSFDDNDS 113

Query: 198 EELNDMDDYD-------------SEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGS 244
           EEL D D                S+DD+D+     K KG++    +  DG  ED+++   
Sbjct: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK 173

Query: 245 GSD----EDENDEGNDEDHSSPASEGGCKKKKSK----VLSRNSADDEELTNDSLTLSQS 296
             +        + G++ D    + +G  K +K+K    + S N  DD      ++   ++
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKA 233

Query: 297 KSNE 300
           +  E
Sbjct: 234 EKKE 237



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 66/311 (21%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 25  SSDDSDFKV------GDASDSEGSGNGSED----------ASKDSGEGSCSDSEENILEE 68
           S DD DF        G A  S    +GSE+           S+ +  G   D  +  L+ 
Sbjct: 137 SDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQS 196

Query: 69  ELNEDIKVKEEQLKN--SAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK-EKEKEK 125
              +    K +   N  S  E+  +S K     +KK E++  ER ++ +EK K  K KEK
Sbjct: 197 RKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEK 256

Query: 126 E------KEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSE 179
           E      K++ ++KE ++    E V +     T     PA  +     T T A ++   +
Sbjct: 257 EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVI--PA--SEEKAETPTAAEDDNEGD 312

Query: 180 PKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRS-ASQKEGSDGDNED 238
            KK + ++ +            + ++ + E         VK    + A  KE  +    +
Sbjct: 313 KKKKDKKKKK-----------GEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE 361

Query: 239 DED--------EGSGSDEDENDEGNDEDHSSPASEGGCK-KKKSKVLSRNSADDEELTND 289
           +E+        E    +E+  ++   E       E   + KK+ K+L+++  +       
Sbjct: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421

Query: 290 SLTLSQSKSNE 300
           +L L Q++  E
Sbjct: 422 TLKLLQAQGVE 432



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 17/130 (13%)

Query: 24  DSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSD-SEENILEEELNEDIKVKEEQLK 82
           +  DD+ FK+   +  +      E   +D  +       E+  LE    +  K KE Q K
Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK 275

Query: 83  NSAEEEVL------------SSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKE 130
              EEE +            +SE++       E++  G++ +K K+K+K +++EKEKEK 
Sbjct: 276 --FEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK- 332

Query: 131 REKEKEKATV 140
            +K   KATV
Sbjct: 333 -KKGPSKATV 341



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 58/271 (21%), Positives = 99/271 (36%), Gaps = 44/271 (16%)

Query: 24  DSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKN 83
           DS+ D       A++ EG+G   E   + S      + ++   +E+   DI  + E+L  
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDED---DILKELEELSL 67

Query: 84  SAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSEN 143
            A+      E   +K  +  EEE   + +KKK ++ +K+   + + E  ++K+  +  + 
Sbjct: 68  EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS-KKT 126

Query: 144 VAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDM 203
                   + +      N  P       A  +     KKW+                   
Sbjct: 127 AKPKVEMYSGSDDDDDFNKLPK-----KAKGKAQKSNKKWD------------------- 162

Query: 204 DDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDEN---------DEG 254
               SE+D D      K K RS     G  GD E DE   S   + +N         + G
Sbjct: 163 ---GSEEDED---NSKKIKERSRINSSGESGD-ESDEFLQSRKGQKKNQKNKPGPNIESG 215

Query: 255 NDEDHSSPASEGGCKKKKSKVLSRNSADDEE 285
           N++D +S   +   +KK  K        DEE
Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEE 246


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 137 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 196

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 197 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 238

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 239 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 298

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 299 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 356



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 256 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 302

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 303 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 341



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 37/133 (27%), Positives = 61/133 (45%), Gaps = 11/133 (8%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 253 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 309

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 310 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 365

Query: 139 TVSENVAASAAAT 151
            V E    S+A T
Sbjct: 366 -VGEGTPQSSALT 377



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 235 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 294

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 295 SEESEEEEEEEEEEEEETGSNSEEASEQSA 324



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/77 (29%), Positives = 42/77 (54%)

Query: 54  GEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRK 113
           G+G     EE + E +L  D++   +  + ++  E  S+E      E++EEEE  E    
Sbjct: 234 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 293

Query: 114 KKEKEKEKEKEKEKEKE 130
             E+ +E+E+E+E+E+E
Sbjct: 294 TSEESEEEEEEEEEEEE 310



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 62/325 (19%), Positives = 122/325 (37%), Gaps = 41/325 (12%)

Query: 51  KDSGEGSCSDSE--ENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENG 108
           +DS   S  + E  ++ +E  +      +E+ +++  EE+   + K   +M +KE+  + 
Sbjct: 41  RDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHH- 99

Query: 109 ERPRKKKEKEKE---KEKEKEKEKEREKEKEKA----------TVSENVAASAAATTPAT 155
            +  K+KEK K    KE+E E+ K   +E++KA           ++   +          
Sbjct: 100 RKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL 159

Query: 156 SPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDY-DSEDDNDW 214
                             E++  E +    R+ R     VS       +DY D    + W
Sbjct: 160 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 219

Query: 215 --------RPTVVKRKGRSASQKEGSD--------GDNEDDEDEGSGSDEDENDEGN--- 255
                   R       GR   ++E  +         D  D E + S ++    + G+   
Sbjct: 220 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 279

Query: 256 -DEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQ 314
            +E+      E G   ++S+       ++EE T  +   +  +S E+    E S++   +
Sbjct: 280 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339

Query: 315 KMDHILICCVCLGD----NSEDADE 335
             +H+L+      D     SE+A+E
Sbjct: 340 NENHLLVVPESRFDRDSGESEEAEE 364


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 147 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 206

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 207 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 248

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 308

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 366



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 34/102 (33%), Positives = 49/102 (48%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE  +   EEE      
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEESEEEEEEEE------ 316

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
                  +EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 317 -------EEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 351



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 37/133 (27%), Positives = 61/133 (45%), Gaps = 11/133 (8%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 263 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 319

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 320 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 375

Query: 139 TVSENVAASAAAT 151
            V E    S+A T
Sbjct: 376 -VGEGTPQSSALT 387



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 245 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 304

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 305 SEESEEEEEEEEEEEEETGSNSEEASEQSA 334



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/77 (29%), Positives = 42/77 (54%)

Query: 54  GEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRK 113
           G+G     EE + E +L  D++   +  + ++  E  S+E      E++EEEE  E    
Sbjct: 244 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 303

Query: 114 KKEKEKEKEKEKEKEKE 130
             E+ +E+E+E+E+E+E
Sbjct: 304 TSEESEEEEEEEEEEEE 320



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 61/335 (18%), Positives = 122/335 (36%), Gaps = 51/335 (15%)

Query: 51  KDSGEGSCSDSE--ENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENG 108
           +DS   S  + E  ++ +E  +      +E+ +++  EE+   + K   +M +KE+  + 
Sbjct: 41  RDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHH- 99

Query: 109 ERPRKKKEK-------------EKEKEKEKEKEKEREKEKEKA----------TVSENVA 145
            +  K+KEK              + KE+E E+ K   +E++KA           ++   +
Sbjct: 100 RKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHS 159

Query: 146 ASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDD 205
                                       E++  E +    R+ R     VS       +D
Sbjct: 160 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 219

Query: 206 Y-DSEDDNDW--------RPTVVKRKGRSASQKEGSD--------GDNEDDEDEGSGSDE 248
           Y D    + W        R       GR   ++E  +         D  D E + S ++ 
Sbjct: 220 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 279

Query: 249 DENDEGN----DEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLI 304
              + G+    +E+      E G   ++S+       ++EE T  +   +  +S E+   
Sbjct: 280 SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 339

Query: 305 LEKSQNWSSQKMDHILICCVCLGD----NSEDADE 335
            E S++   +  +H+L+      D     SE+A+E
Sbjct: 340 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 138 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 197

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 198 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 239

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 240 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 300 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 357



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 257 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 303

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 304 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 342



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 18/146 (12%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 254 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 310

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 311 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 366

Query: 139 TVSENVAASAAAT-------TPATSP 157
            V E    S+A T       +PA SP
Sbjct: 367 -VGEGTPQSSALTEGDYVPDSPALSP 391



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 236 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 295

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 296 SEESEEEEEEEEEEEEETGSNSEEASEQSA 325



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 61/325 (18%), Positives = 122/325 (37%), Gaps = 40/325 (12%)

Query: 51  KDSGEGSCSDSE--ENILEEELNEDIKVKEEQLKNSAEEE---VLSSEKQLIKMEKKEEE 105
           +DS   S  + E  ++ +E  +      +E+ +++  EE+    +   +Q+ + EK    
Sbjct: 41  RDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHR 100

Query: 106 ENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA----------TVSENVAASAAATTPAT 155
           ++ +R  KK  + KEKE+E E+ K   +E++KA           ++   +          
Sbjct: 101 KDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL 160

Query: 156 SPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDY-DSEDDNDW 214
                             E++  E +    R+ R     VS       +DY D    + W
Sbjct: 161 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 220

Query: 215 --------RPTVVKRKGRSASQKEGSD--------GDNEDDEDEGSGSDEDENDEGN--- 255
                   R       GR   ++E  +         D  D E + S ++    + G+   
Sbjct: 221 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 280

Query: 256 -DEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQ 314
            +E+      E G   ++S+       ++EE T  +   +  +S E+    E S++   +
Sbjct: 281 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340

Query: 315 KMDHILICCVCLGD----NSEDADE 335
             +H+L+      D     SE+A+E
Sbjct: 341 NENHLLVVPESRFDRDSGESEEAEE 365


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 115 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 174

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 175 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 216

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 217 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 276

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 277 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 334



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 234 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 280

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 281 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 319



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 18/146 (12%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 231 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 287

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 288 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 343

Query: 139 TVSENVAASAAAT-------TPATSP 157
            V E    S+A T       +PA SP
Sbjct: 344 -VGEGTPQSSALTEGDYVPDSPALSP 368



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 213 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 272

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 273 SEESEEEEEEEEEEEEETGSNSEEASEQSA 302



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/77 (29%), Positives = 42/77 (54%)

Query: 54  GEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRK 113
           G+G     EE + E +L  D++   +  + ++  E  S+E      E++EEEE  E    
Sbjct: 212 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 271

Query: 114 KKEKEKEKEKEKEKEKE 130
             E+ +E+E+E+E+E+E
Sbjct: 272 TSEESEEEEEEEEEEEE 288



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 71/348 (20%), Positives = 127/348 (36%), Gaps = 47/348 (13%)

Query: 26  SDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSA 85
           SDD D K     + E   +  E   ++S      DS E+  EE+ +  IK   +Q+    
Sbjct: 4   SDDRDSKRDSLEEGELRDHRMEITIRNSPYRR-EDSMEDRGEEDDSLAIK-PPQQMSRKE 61

Query: 86  EEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREK------EKEKAT 139
           +      EK+  K   +     G +  + KEKE+E E+ K   +E++K       +++  
Sbjct: 62  KVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRRE 121

Query: 140 VSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEE 199
           ++   +                            E++  E +    R+ R     VS   
Sbjct: 122 MAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHH 181

Query: 200 LNDMDDY-DSEDDNDW--------RPTVVKRKGRSASQKEGSD--------GDNEDDE-- 240
               +DY D    + W        R       GR   ++E  +         D  D E  
Sbjct: 182 RTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERK 241

Query: 241 ---------DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSL 291
                    + GSGS+E+E +E  +E+  S + E       S+       ++EE T  + 
Sbjct: 242 TSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE-------SEEEEEEEEEEEEETGSNS 294

Query: 292 TLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGD----NSEDADE 335
             +  +S E+    E S++   +  +H+L+      D     SE+A+E
Sbjct: 295 EEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 342


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 104 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 163

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 164 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 205

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 206 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 265

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 266 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 323



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 223 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 269

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 270 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 308



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 18/146 (12%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 220 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 276

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 277 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 332

Query: 139 TVSENVAASAAAT-------TPATSP 157
            V E    S+A T       +PA SP
Sbjct: 333 -VGEGTPQSSALTEGDYVPDSPALSP 357



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 62/330 (18%), Positives = 124/330 (37%), Gaps = 40/330 (12%)

Query: 46  SEDASKDSGEGSCSDSE--ENILEEELNEDIKVKEEQLKNSAEEE---VLSSEKQLIKME 100
           S+   +DS   S  + E  ++ +E  +      +E+ +++  EE+    +   +Q+ + E
Sbjct: 2   SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 61

Query: 101 KKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA----------TVSENVAASAAA 150
           K    ++ +R  KK  + KEKE+E E+ K   +E++KA           ++   +     
Sbjct: 62  KVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERD 121

Query: 151 TTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDY-DSE 209
                                  E++  E +    R+ R     VS       +DY D  
Sbjct: 122 RLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 181

Query: 210 DDNDW--------RPTVVKRKGRSASQKEGSD--------GDNEDDEDEGSGSDEDENDE 253
             + W        R       GR   ++E  +         D  D E + S ++    + 
Sbjct: 182 KASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241

Query: 254 GN----DEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQ 309
           G+    +E+      E G   ++S+       ++EE T  +   +  +S E+    E S+
Sbjct: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301

Query: 310 NWSSQKMDHILICCVCLGD----NSEDADE 335
           +   +  +H+L+      D     SE+A+E
Sbjct: 302 DEERENENHLLVVPESRFDRDSGESEEAEE 331


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           + ++ +  A E       +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 149 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 208

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 209 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 250

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 251 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 310

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 311 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 368



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 268 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 314

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 315 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 353



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 18/146 (12%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 265 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 321

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 322 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 377

Query: 139 TVSENVAASAAAT-------TPATSP 157
            V E    S+A T       +PA SP
Sbjct: 378 -VGEGTPQSSALTEGDYVPDSPALSP 402



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 247 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 306

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 307 SEESEEEEEEEEEEEEETGSNSEEASEQSA 336



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/77 (29%), Positives = 42/77 (54%)

Query: 54  GEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRK 113
           G+G     EE + E +L  D++   +  + ++  E  S+E      E++EEEE  E    
Sbjct: 246 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 305

Query: 114 KKEKEKEKEKEKEKEKE 130
             E+ +E+E+E+E+E+E
Sbjct: 306 TSEESEEEEEEEEEEEE 322



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 71/349 (20%), Positives = 128/349 (36%), Gaps = 47/349 (13%)

Query: 25  SSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNS 84
           +SDD D K     + E   +  E   ++S      DS E+  EE+ +  IK   +Q+   
Sbjct: 37  NSDDRDSKRDSLEEGELRDHRMEITIRNSPYRR-EDSMEDRGEEDDSLAIK-PPQQMSRK 94

Query: 85  AEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREK------EKEKA 138
            +      EK+  K   +     G +  + KEKE+E E+ K   +E++K       +++ 
Sbjct: 95  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154

Query: 139 TVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSME 198
            ++   +                            E++  E +    R+ R     VS  
Sbjct: 155 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214

Query: 199 ELNDMDDY-DSEDDNDW--------RPTVVKRKGRSASQKEGSD--------GDNEDDE- 240
                +DY D    + W        R       GR   ++E  +         D  D E 
Sbjct: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 274

Query: 241 ----------DEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS 290
                     + GSGS+E+E +E  +E+  S + E       S+       ++EE T  +
Sbjct: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE-------SEEEEEEEEEEEEETGSN 327

Query: 291 LTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGD----NSEDADE 335
              +  +S E+    E S++   +  +H+L+      D     SE+A+E
Sbjct: 328 SEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 376


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 53/238 (22%), Positives = 108/238 (45%), Gaps = 30/238 (12%)

Query: 77  KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEK------EKEKEKEKE 130
           +E   +    + V     +L ++E+K E E   R ++K+++E+++      E+ KE+E  
Sbjct: 147 REHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 206

Query: 131 REKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRP 190
           RE      T+ E+ +    A+  + SPP                      +++ L   R 
Sbjct: 207 REVSAHHRTMREDYSDKVKASHWSRSPPR------------------PPRERFELGDGRK 248

Query: 191 LLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG-RSASQKEGSDGDNEDDEDEGSGSDE- 248
            +    MEE + + D     D++ + +  +     S S  E  + + E++E+EGS S+E 
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 308

Query: 249 --DENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDS--LTLSQSKSNEDS 302
             +E +E  +E+ +   SE   ++   +V     ++DEE  N++  L + +S+ + DS
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 366



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 16/102 (15%)

Query: 35  DASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEK 94
           D SDSE   + +E +S +SG GS  + EE   EEE  E+    EE    S EEE      
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEE---EEEEEEEGSTSEE----SEEEE------ 312

Query: 95  QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
              + E++EEEE G    +  E+  E+  E+E  ++ E+E E
Sbjct: 313 ---EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 351



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 18/146 (12%)

Query: 22  DYDSSDDSDFKVGDASDSE---GSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
           D     DS+ K   A  S    GSG+  E+  ++  E   S SEE+  EEE  E+   +E
Sbjct: 263 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---EE 319

Query: 79  EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
           E+  +++EE    S +++ + E  E+EE           E   +++  + +E E+E    
Sbjct: 320 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---- 375

Query: 139 TVSENVAASAAAT-------TPATSP 157
            V E    S+A T       +PA SP
Sbjct: 376 -VGEGTPQSSALTEGDYVPDSPALSP 400



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 24/90 (26%), Positives = 47/90 (52%)

Query: 60  DSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEK 119
           D  + + EE++ E   + + Q  + +E +  S+E    +     EEE  E   +++E   
Sbjct: 245 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 304

Query: 120 EKEKEKEKEKEREKEKEKATVSENVAASAA 149
            +E E+E+E+E E+E+E  + SE  +  +A
Sbjct: 305 SEESEEEEEEEEEEEEETGSNSEEASEQSA 334



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 70/348 (20%), Positives = 131/348 (37%), Gaps = 47/348 (13%)

Query: 25  SSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNS 84
           +SDD D K     + E   +  E   ++S      DS E+  EE+ +  IK   +Q+   
Sbjct: 37  NSDDRDSKRDSLEEGELRDHCMEITIRNSPYRR-EDSMEDRGEEDDSLAIK-PPQQMSRK 94

Query: 85  AEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKE----KEKEKEKEKEREKEKEKATV 140
            +      EK+  K   + +E+  E  R+K+ +E++    +E E++K +E  +E  +   
Sbjct: 95  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154

Query: 141 SENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEEL 200
             +                              E++  E +    R+ R     VS    
Sbjct: 155 GNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 214

Query: 201 NDMDDYDSE------------------DDNDWRPTVVKRKGR-----------SASQKEG 231
              +DY  +                  +  D R  V + K             S S+++ 
Sbjct: 215 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 274

Query: 232 SDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSL 291
           S  ++   E  GSGS+E+E +E  +E+  S + E       S+       ++EE T  + 
Sbjct: 275 SSAESSSAE-SGSGSEEEEEEEEEEEEEGSTSEE-------SEEEEEEEEEEEEETGSNS 326

Query: 292 TLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGD----NSEDADE 335
             +  +S E+    E S++   +  +H+L+      D     SE+A+E
Sbjct: 327 EEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 59/265 (22%), Positives = 104/265 (39%), Gaps = 26/265 (9%)

Query: 19  EALDYDSSDDSDFKVGDASDSEGSGNGS-------EDASKDSGEGSCSDSEENILEEELN 71
           +A     ++D     GD +  EGS           E   KD G G      E   E    
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699

Query: 72  EDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKE----- 126
           E+ K ++ + +   E E    +++  +ME+  EEE+GE   ++ ++E+E+EKE E     
Sbjct: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759

Query: 127 --KEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEE----QVSEP 180
             +E E E+EKE+    +   A                           EE    +  E 
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819

Query: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240
           ++    R     +    EE  + ++ + E + +        +G    ++EG +G+ E++ 
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE--------EGEGKGEEEGEEGEGEEEG 871

Query: 241 DEGSGSDEDENDEGNDEDHSSPASE 265
           +EG G  E+E  EG  E+      E
Sbjct: 872 EEGEGEGEEEEGEGEGEEEGEGEGE 896



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 58/251 (23%), Positives = 97/251 (38%), Gaps = 39/251 (15%)

Query: 27   DDSDFKVGDASDSEGSGNGSEDASKDSG----EGSCSDSEENILEEELNEDIKVKEEQLK 82
            ++ D   G+  ++EG G   E+  +  G    EG     EE    E   E+ + +EE+ +
Sbjct: 789  EEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE 848

Query: 83   NSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKE---KEKEREKEKEKAT 139
               EE     E++  + E +EE E GE   +++E E E E+E E   +E+E E E E+  
Sbjct: 849  GEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG 908

Query: 140  VSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEE 199
              E                               EE+  E                   E
Sbjct: 909  EGEGEEEEGEGKGEEEGEEGEGEG----------EEEEGE------------------GE 940

Query: 200  LNDMDDYDSEDDNDWRPTVVKRKGRSASQKEG----SDGDNEDDEDEGSGSDEDENDEGN 255
              D +    E++ +W     + +G    + EG     +G+ E++E EG G +E+  +EG 
Sbjct: 941  GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000

Query: 256  DEDHSSPASEG 266
            +E       EG
Sbjct: 1001 EEGEGEEEGEG 1011



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 62/281 (22%), Positives = 110/281 (39%), Gaps = 45/281 (16%)

Query: 19  EALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSC---SDSEENILEEELNEDIK 75
           E L  D +D ++   G A     S   +ED  +  G+G+C   S   E+  +EE  +  K
Sbjct: 624 EILSDDLTDKAEVSEGKAK----SVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679

Query: 76  VKEE-QLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKE 134
            K   +++   E E   +EK+  K    EE+E  ER +  +++  ++ +E  +E+  E E
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE 739

Query: 135 KEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDF 194
           +E+    E                               EE   E +K    R +     
Sbjct: 740 EEEGDREEEEEKEGEGKEEGEG-----------------EEVEGEREKEEGERKK----- 777

Query: 195 VSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSD----------GDNEDDEDEGS 244
              EE    ++   E+ +       + +GR   ++EG +          G+ E++E+EG 
Sbjct: 778 ---EERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGE 834

Query: 245 GSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEE 285
           G  E+E  EG +E+      EG  K ++         + EE
Sbjct: 835 G--EEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEE 873



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 55/234 (23%), Positives = 90/234 (38%), Gaps = 8/234 (3%)

Query: 38  DSEGSGNGSEDASKDSGEGSCSDSE-ENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQL 96
           + E  G G E+   +  EG     E E   EE   ++ K +EE  +   EEE   +E + 
Sbjct: 748 EEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE--ETEGRG 805

Query: 97  IKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATS 156
            + E+  E E GE    K E+E+E+E+ + +E+E E E+E+    E              
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865

Query: 157 PPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRP 216
                            EE   E ++               EE  + +  + E +     
Sbjct: 866 EGEEEGEEG--EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE 923

Query: 217 TVVKRKGRSASQK---EGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGG 267
              + +G    ++   EG DG+ E +E+EG    E+E  EG  E+      E G
Sbjct: 924 EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 31/103 (30%), Positives = 54/103 (52%), Gaps = 1/103 (0%)

Query: 34   GDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSE 93
            G+  + EG G G E+  ++ GE      EE   E E  E+ +V+ E      E E    E
Sbjct: 979  GEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEE 1038

Query: 94   KQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
             +  + E++E+E  GE  R+ +E+E+E+E + ++  E E E++
Sbjct: 1039 GE-EEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 8/110 (7%)

Query: 34   GDASDSEGSGNGSEDASKDSGEGSCSDSE------ENILEEELNEDIKVKEEQLKNSAEE 87
            G+  + EG G G E+  +  GEG   + E      E   EEE  E  + +EE+ +   EE
Sbjct: 910  GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE-WEGEEEEGEGEGEE 968

Query: 88   EVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEK 137
            E    E +  + E +EEE  GE   ++ E+E E+E E E+E E E E+E+
Sbjct: 969  EG-EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 36/106 (33%), Positives = 54/106 (50%), Gaps = 9/106 (8%)

Query: 34   GDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEE--VLS 91
            G+    EG G G E    + GEG   + EE   EEE  E+ + +EE      EEE   + 
Sbjct: 970  GEGEGEEGEGEGEE----EEGEG---EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022

Query: 92   SEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEK 137
             E +  + E + EEE GE   +++EKE E E+ +   +E E+E+ K
Sbjct: 1023 GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 32/105 (30%), Positives = 49/105 (46%)

Query: 38   DSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLI 97
            + EG G G E   +   E    + EE   EEE  E+ + +EE      EEE    E ++ 
Sbjct: 967  EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026

Query: 98   KMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSE 142
              E + E E  E   + +E+EKE E E+ +    E+E+E+    E
Sbjct: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 52/243 (21%), Positives = 91/243 (37%), Gaps = 31/243 (12%)

Query: 24   DSSDDSDFKVGDASDSEGSGNGSEDASK-------DSGEGSCSDSEENILEEELNEDIKV 76
            +   + + + G+  + EG G G E+  +       + GEG   + EE   E E   + + 
Sbjct: 837  EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE-GEEEEGEGEGEEEGEGEG 895

Query: 77   KEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKE 136
            +EE+ +   EEE    E +  + E K EEE  E   + +E+E E E E  + +  E+E E
Sbjct: 896  EEEEGEGEGEEEG-EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954

Query: 137  KATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVS 196
                 E                               EE+  E  +              
Sbjct: 955  WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE-------------- 1000

Query: 197  MEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGND 256
             EE    ++ + E + +        +G    + EG +G+ E +E+EG    E+   EG  
Sbjct: 1001 -EEGEGEEEGEGEGEEE-------EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052

Query: 257  EDH 259
            E++
Sbjct: 1053 EEN 1055



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 2/106 (1%)

Query: 34   GDASDSEGSGNGSEDASKDSGEGSCSDSE-ENILEEELNEDIKVKEEQLKNSAEEEVLSS 92
            G+  + EG G    +   + GEG   + E E   EEE  E+   +E + +   E E    
Sbjct: 957  GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE 1016

Query: 93   EKQLIKMEKKEEEENGERPRKKKEKE-KEKEKEKEKEKEREKEKEK 137
            E+  ++ E + EE  GE   ++ E+E +E+EKE E E+ R   +E+
Sbjct: 1017 EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEE 1062



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 56/279 (20%), Positives = 110/279 (39%), Gaps = 63/279 (22%)

Query: 15  ASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCS-----DSEENILEEE 69
           A+ +EA   +  +  + K G A DS+G  NG E+   ++ E +         +  IL ++
Sbjct: 573 ATTIEAFSDEEVEIPEEKEG-AEDSKG--NGIEEQEVEANEENVKVHGGRKEKTEILSDD 629

Query: 70  LNEDIKVKEEQLKNSAEEE---------VLSSEKQLIKMEKKEEEENGERPRKKKEKEKE 120
           L +  +V E + K+  E E                  +  + EE E GE+ + + E E+ 
Sbjct: 630 LTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689

Query: 121 KEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEP 180
            E EKE  ++ E +K                                      EEQ  + 
Sbjct: 690 GEGEKELAEKEEWKKRDG-----------------------------------EEQEQKE 714

Query: 181 KKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDE 240
           ++   ++ R       MEE  + +  + E++   R    +++G    + EG + + E ++
Sbjct: 715 REQGHQKERNQ----EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK 770

Query: 241 DEG-------SGSDEDENDEGNDEDHSSPASEGGCKKKK 272
           +EG       +G +E   +EG+  +     +EG  ++K+
Sbjct: 771 EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE 809



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 47/209 (22%), Positives = 77/209 (36%), Gaps = 11/209 (5%)

Query: 88  EVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEK-------EKATV 140
           E  S E+  I  EK+  E++     +++E E  +E  K     +EK +       +KA V
Sbjct: 577 EAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEV 636

Query: 141 SENVAASAAATTPATSPPAVNT---SPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSM 197
           SE  A S              T     S        E +  E  K      RP      +
Sbjct: 637 SEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKEL 696

Query: 198 EELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEG-ND 256
            E  +    D E+          +K R+   +EG + ++ + E+E    +E+E  EG   
Sbjct: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756

Query: 257 EDHSSPASEGGCKKKKSKVLSRNSADDEE 285
           E+      EG  +K++ +      A  EE
Sbjct: 757 EEGEGEEVEGEREKEEGERKKEERAGKEE 785



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 51/273 (18%), Positives = 102/273 (37%), Gaps = 47/273 (17%)

Query: 61  SEENILEEELNE---DIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEK 117
           SE+++++ E  +   D   KE ++ NS+  E L     ++ M       + E+  K    
Sbjct: 461 SEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPV 520

Query: 118 EKEKEK----------------EKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVN 161
           +K+K++                + ++ +E  + KE     ++V+     T PAT+  A  
Sbjct: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAF- 579

Query: 162 TSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKR 221
              S        E++ +E  K N            +EE     + ++ ++N      VK 
Sbjct: 580 ---SDEEVEIPEEKEGAEDSKGN-----------GIEE----QEVEANEEN------VKV 615

Query: 222 KGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSA 281
            G    +KE ++  ++D  D+   S+      G  ED      +G C++  S        
Sbjct: 616 HG---GRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE 672

Query: 282 DDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQ 314
           + E+   D       +  E    L + + W  +
Sbjct: 673 EREKGEKDKGRGEMERPGEGEKELAEKEEWKKR 705


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 80/309 (25%), Positives = 132/309 (42%), Gaps = 51/309 (16%)

Query: 21   LDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEEN-ILEEELNEDIKVKEE 79
            LD DS   +   + +A+ SE      ++A +   + SC + EE  IL    N      + 
Sbjct: 980  LDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKV 1039

Query: 80   QLKN----SAEEEVLSSEK-QLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKE 134
            Q KN    S E   ++ E+ QL+++ K+  EE  E   +++E+E+E+E+E E+E+E E+E
Sbjct: 1040 QSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEE 1099

Query: 135  KEKATVSENVAASAAATTPATSPPAVNTSP----------------SVPT-TTTATEEQV 177
            +E+    EN+ +S    T   S       P                SV T T + T E +
Sbjct: 1100 EEE---EENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVL 1156

Query: 178  SEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKR-------KGRSASQKE 230
            +EP   N    RP      M +L    + + E+D   R  V+++       K R   ++E
Sbjct: 1157 NEPFD-NSDEERP------MPQLEPTCEIEVEEDG--RKPVLRKAFQHQPGKKRQTEEEE 1207

Query: 231  GSDGD--NEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCK----KKKSKVLSRNSADDE 284
            G D       D    + +D+  N +   +D+  P     CK    K   + LS+   + E
Sbjct: 1208 GKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLK---CKQVWPKGTKRGLSKWRQNKE 1264

Query: 285  ELTNDSLTL 293
              T   L L
Sbjct: 1265 RKTGFKLNL 1273



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 15/68 (22%)

Query: 718 TSTLPAVLYSCGICK---------KNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKN 768
           T+ + A+ + C  CK         +N D   +L CD+C   +H+ C DPPL+RMP+    
Sbjct: 256 TTNVKALRWQCIECKTCSACRVQGRNADN--MLFCDSCDRGFHMECCDPPLSRMPK---- 309

Query: 769 SYWQCSEC 776
             W C  C
Sbjct: 310 GMWICQVC 317



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 46/203 (22%), Positives = 75/203 (36%), Gaps = 50/203 (24%)

Query: 48   DASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEEN 107
            +  K++ EG  S S   I EEE+ E  +    Q +N  EE            EK E++  
Sbjct: 1290 EEQKETSEGKTSPSPIRI-EEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLI 1348

Query: 108  GERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVP 167
                 +++E+E+E+E+E+E+ +E E                           V   P   
Sbjct: 1349 KPEEEEEEEEEEEEEEEEEEGEEEE-----------------------GGGNVEKDPDGA 1385

Query: 168  TTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSAS 227
             +    E ++S  K+ + R                +DD++ E++ D  P          S
Sbjct: 1386 KSQEKEEPEISTEKEDSAR----------------LDDHEEEEEEDEEP----------S 1419

Query: 228  QKEGSDGDNEDDEDEGSGSDEDE 250
              E  D D+EDD    S   E E
Sbjct: 1420 HNEDHDADDEDDSHMESAEVEKE 1442



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 27/114 (23%), Positives = 42/114 (36%), Gaps = 25/114 (21%)

Query: 315 KMDHILICCVCLG----DNSEDADEIIQCDNCGITVHEGCYG----------------VD 354
           + D I IC  CLG    +  +  +E++ C +CG + H  C                  ++
Sbjct: 209 RADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIE 268

Query: 355 GESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVC 408
            ++ S       N+    FCD+C  G    C  C   D        G W+  VC
Sbjct: 269 CKTCSACRVQGRNADNMLFCDSCDRGFHMEC--C---DPPLSRMPKGMWICQVC 317



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 34/145 (23%), Positives = 59/145 (40%), Gaps = 13/145 (8%)

Query: 47   EDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEE-VLSSEKQLIKM--EKKE 103
            E+  ++  E    + EE   EEE   +++   +  K+  +EE  +S+EK+      + +E
Sbjct: 1351 EEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEE 1410

Query: 104  EEENGERPRKKKEKEKEKEKEKEKE------KEREKEKEKATVSENVAASAAATTPATSP 157
            EEE  E P   ++ + + E +   E      +E  +E  K  +            P  S 
Sbjct: 1411 EEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSN 1470

Query: 158  PAVNTSPSVPTTTTATEEQVSEPKK 182
            P V     V  T +      SEPK+
Sbjct: 1471 PEVLMDCGVDLTASCN----SEPKE 1491



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 53/296 (17%), Positives = 101/296 (34%), Gaps = 29/296 (9%)

Query: 19   EALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKE 78
            E  + +  ++ + +  +  + EG GN      KD       + EE  +  E  +  ++ +
Sbjct: 1352 EEEEEEEEEEEEEEEEEGEEEEGGGN----VEKDPDGAKSQEKEEPEISTEKEDSARLDD 1407

Query: 79   EQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKA 138
             + +   +EE   +E      E     E+ E  +++  +E  KE  + +E   +   +  
Sbjct: 1408 HEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPG 1467

Query: 139  TVSENVAASAAATTPAT----------SPPAVNTSPSVPTTTTATEEQVSEPKK---WNL 185
              +  V         A+           P AV  S   P      ++Q  +  K      
Sbjct: 1468 HSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEF 1527

Query: 186  RRNRPL---LDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDE 242
            +   P    +D  +++ +  +    SE D+ ++          A  +E           +
Sbjct: 1528 KEGNPATMEIDSETVQAVQSLTQESSEQDDTFQD--------CAETQEACRSLQNYTRAD 1579

Query: 243  GSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKS 298
             S       D+    DHSSP S       +S V S NS     L N    +S  +S
Sbjct: 1580 QSPQIATTLDDCQQSDHSSPVSSVHSHPGQS-VRSVNSPSVPALENSYAQISPDQS 1634



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 49/266 (18%), Positives = 91/266 (34%), Gaps = 35/266 (13%)

Query: 47   EDASKDSGEGSCSDSEENILEEE---LNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKE 103
            E+  KD+     +D   N + ++   L E  K   E LK   +     +++ L K  + +
Sbjct: 1205 EEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLK-CKQVWPKGTKRGLSKWRQNK 1263

Query: 104  EEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTS 163
            E + G +       E   E +++   E +KE  +                 TSP  +   
Sbjct: 1264 ERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGK---------------TSPSPIRIE 1308

Query: 164  PSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKG 223
              V  T  A   Q    ++       P          N       EDD      ++K + 
Sbjct: 1309 EEVKETGEALLPQEENRREETCAPVSP----------NTSPGEKPEDD------LIKPEE 1352

Query: 224  RSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADD 283
                ++E  + + E++ +E  G    E D    +       E   +K+ S  L  +  ++
Sbjct: 1353 EEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEE 1412

Query: 284  EELTNDSLTLSQSKSNEDSLILEKSQ 309
            EE    S        +ED   +E ++
Sbjct: 1413 EEDEEPSHNEDHDADDEDDSHMESAE 1438


>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
          Length = 726

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 78/292 (26%), Positives = 117/292 (40%), Gaps = 43/292 (14%)

Query: 42  SGNGSEDASKDSGEGSCSDSEENILEE--ELNEDIKVKEEQLKNSAEEEVLSSEKQLIKM 99
           S   SE++S DSG    SDSEE       EL E +K   EQL   ++  V   +K   K 
Sbjct: 439 SSRSSEESSSDSGS---SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKK---KK 492

Query: 100 EKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEK----EKATVSENVAASAAATTPAT 155
           EKKE+E      +KKK+KEKEKEK K K +E +K K     K    +   A  A +T   
Sbjct: 493 EKKEKE------KKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTA 546

Query: 156 SPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPL-------------LDFVSMEELND 202
                        +  + EE+   P  ++ +R   L             +  +   E + 
Sbjct: 547 GRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSL 606

Query: 203 MDDYDSEDDNDW---RPTVVK---RKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGND 256
            D    E + D+   +PT ++   R  +S  QK+     +   + + + S E+   E   
Sbjct: 607 RDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKK 666

Query: 257 E------DHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDS 302
           E      D S   S      +K K  S  S     L++ S + S S S+  S
Sbjct: 667 ELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGS 718


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,242,690
Number of Sequences: 37866
Number of extensions: 2103665
Number of successful extensions: 69906
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1187
Number of HSP's successfully gapped in prelim test: 1155
Number of HSP's that attempted gapping in prelim test: 18130
Number of HSP's gapped (non-prelim): 23040
length of query: 888
length of database: 18,247,518
effective HSP length: 111
effective length of query: 777
effective length of database: 14,044,392
effective search space: 10912492584
effective search space used: 10912492584
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.