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Search of human proteins with 55749544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749544 SH3 multiple domains 1 [Homo sapiens]
(1105 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749544 SH3 multiple domains 1 [Homo sapiens] 2226 0.0
gi|63055059 SH3 and PX domains 2B [Homo sapiens] 528 e-149
gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] 208 3e-53
gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens] 96 1e-19
gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens] 94 5e-19
gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens] 92 3e-18
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 84 7e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 67 9e-11
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 67 9e-11
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 67 9e-11
gi|11321634 CD2-associated protein [Homo sapiens] 65 4e-10
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 65 4e-10
gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens] 65 5e-10
gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens] 65 5e-10
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 64 1e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 63 1e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 63 1e-09
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 63 2e-09
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 62 2e-09
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 62 2e-09
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 58 6e-08
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 56 2e-07
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 56 2e-07
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 53 2e-06
gi|55741677 SET domain containing 1A [Homo sapiens] 52 2e-06
gi|20149528 proline-serine-threonine phosphatase interacting pro... 52 2e-06
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens] 52 3e-06
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens] 52 3e-06
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens] 52 3e-06
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens] 52 3e-06
>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
Length = 1105
Score = 2226 bits (5769), Expect = 0.0
Identities = 1105/1105 (100%), Positives = 1105/1105 (100%)
Query: 1 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI 60
MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI
Sbjct: 1 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI 60
Query: 61 EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF 120
EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF
Sbjct: 61 EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF 120
Query: 121 FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ 180
FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ
Sbjct: 121 FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ 180
Query: 181 ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEE 240
ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEE
Sbjct: 181 ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEE 240
Query: 241 EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP 300
EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP
Sbjct: 241 EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP 300
Query: 301 TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN 360
TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN
Sbjct: 301 TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN 360
Query: 361 GSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPS 420
GSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPS
Sbjct: 361 GSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPS 420
Query: 421 VEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKP 480
VEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKP
Sbjct: 421 VEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKP 480
Query: 481 NLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSE 540
NLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSE
Sbjct: 481 NLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSE 540
Query: 541 PELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPY 600
PELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPY
Sbjct: 541 PELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPY 600
Query: 601 AEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSA 660
AEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSA
Sbjct: 601 AEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSA 660
Query: 661 SFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTS 720
SFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTS
Sbjct: 661 SFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTS 720
Query: 721 CPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAS 780
CPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAS
Sbjct: 721 CPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAS 780
Query: 781 EAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQ 840
EAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQ
Sbjct: 781 EAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQ 840
Query: 841 VLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEK 900
VLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEK
Sbjct: 841 VLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEK 900
Query: 901 IERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPP 960
IERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPP
Sbjct: 901 IERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPP 960
Query: 961 KDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPA 1020
KDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPA
Sbjct: 961 KDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPA 1020
Query: 1021 QRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGW 1080
QRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGW
Sbjct: 1021 QRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGW 1080
Query: 1081 WYCQILDGVKPFKGWVPSNYLEKKN 1105
WYCQILDGVKPFKGWVPSNYLEKKN
Sbjct: 1081 WYCQILDGVKPFKGWVPSNYLEKKN 1105
>gi|63055059 SH3 and PX domains 2B [Homo sapiens]
Length = 911
Score = 528 bits (1359), Expect = e-149
Identities = 326/776 (42%), Positives = 426/776 (54%), Gaps = 109/776 (14%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
+ + V+DV+KRR P+KHYVYII VTWS +++ IYRRYSKFFDLQMQ+LDKFP+EGGQK
Sbjct: 7 IVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQK 66
Query: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125
DPKQRIIPFLPGKILFRRSHIRDVAVKRL PIDEYC+AL++LPP+ISQCDEV +FFE RP
Sbjct: 67 DPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRP 126
Query: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSEL 185
ED+NPPKE++ K+ G + +PM+LEQYVVV+NY+KQE+SE+
Sbjct: 127 EDLNPPKEEHIGKKKSG---------------GDQTSVDPMVLEQYVVVANYQKQESSEI 171
Query: 186 SLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVT 245
SL G+VVD+IEKNESGWWFVST+EEQGWVPAT LE Q+G +D+ + EEEKY
Sbjct: 172 SLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---EEEKYTV 228
Query: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
+ PYT++ +DE+ E+G VEVI+KNLEGWW IRY GKEGWAPASYLKK
Sbjct: 229 IYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------- 277
Query: 306 LAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVG 365
+ + PP G G +P + L + N AVG
Sbjct: 278 ----------------------NSGEPLPPKPGPG--SPSHPGALDLDGVSRQQN--AVG 311
Query: 366 VPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEV 423
+S G + A+ SP +R RPPPRR+ ++ G LPKPP PP VE
Sbjct: 312 REKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEE 371
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLS 483
EYYTIAEFQ+ I DGISF+ G K EVI+KN GWWY+QI +KEGWAPA++IDK KK
Sbjct: 372 EYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKK---- 427
Query: 484 RRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPEL 543
TS +RP P P + + G A E+ P D P DS
Sbjct: 428 --TSNASRPNFLAPL-PHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPW 484
Query: 544 SEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFR 598
S++ V +AS + + + ++ + + E + E + E E R
Sbjct: 485 SKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGELLERERER 543
Query: 599 PYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHS 658
+ T RG + PG + K+ P + + S + K +K+ ++ KN
Sbjct: 544 ---QRTEQLRGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLFQL-KNDM 594
Query: 659 SASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGL 718
+ + +SK+ DL P DA TP+ N L
Sbjct: 595 GLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ---------NPFL 636
Query: 719 TSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSEL 774
S P+ +P P P Q ++++DI LR +LRP +KS+D L
Sbjct: 637 KSRPQVRPKPAPSP--KTEPPQGEDQVDICNLRSKLRP----------AKSQDKSL 680
Score = 87.4 bits (215), Expect = 7e-17
Identities = 35/63 (55%), Positives = 50/63 (79%), Gaps = 1/63 (1%)
Query: 1043 NNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYL 1101
+ LKD +YV++AD+EGD++T+ FQEG EV E+N +GWW+CQ+L G ++GW+PSNYL
Sbjct: 848 DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907
Query: 1102 EKK 1104
KK
Sbjct: 908 RKK 910
Score = 85.9 bits (211), Expect = 2e-16
Identities = 81/299 (27%), Positives = 129/299 (43%), Gaps = 43/299 (14%)
Query: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL-----VLDE- 870
Y+ + YQK + SEIS G V ++EK ESGWW+V E +GW P+ L V DE
Sbjct: 157 YVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEF 216
Query: 871 NEQPDPSGKELDTVPAKGRQ----NEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPP 926
+ QP+ K P R N + +E I++ ++ + K P
Sbjct: 217 SLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEG----WAPA 272
Query: 927 GGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPP-PKDNNLSCALRRNESLTATDGLRGVR 985
K SG P + P+ SP P +L R+ ++ L +
Sbjct: 273 SYLKKNSGEP------------LPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQ 320
Query: 986 RNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNL 1045
R+ F +AK +R+ P P + +IP PKP Q +
Sbjct: 321 RDGRFEGRPVPDGDAK----QRSPKMRQRPP--PRRDMTIPRGLNLPKPPIPPQ-----V 369
Query: 1046 KDVYVSIADYEGD-EETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
++ Y +IA+++ + FQ G+ +EV+E+N +GWWY QI D +GW P+ +++K
Sbjct: 370 EEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDK----EGWAPATFIDK 424
Score = 64.7 bits (156), Expect = 5e-10
Identities = 58/218 (26%), Positives = 95/218 (43%), Gaps = 24/218 (11%)
Query: 745 MDISTLRRQLRPTG---QLRGGLKGSKSEDSELPPQTASE-APSEGSRRSSSDLITLPA- 799
+D+ + RQ G +L + + E +P A + +P R +T+P
Sbjct: 298 LDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRG 357
Query: 800 ---TTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE 856
PP P + E E Y T + +Q ISF AG++V+V+EK SGWWY++ +
Sbjct: 358 LNLPKPPIPPQVEEE-----YYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIED 412
Query: 857 LEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQ-NEGKSDSLEKIERRVQALNTVNQSK 915
EGWAP+ ++ + L +P + Q G++ +LE NT +++
Sbjct: 413 KEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALEN--------NTGSEAT 464
Query: 916 KATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQS 953
+ P+P P G SG P K G + V + S
Sbjct: 465 GPSRPLPDAPHGVM--DSGLPWSKDWKGSKDVLRKASS 500
Score = 49.7 bits (117), Expect = 2e-05
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 31/166 (18%)
Query: 325 KKASGDKETPPAEG---EGHE---APIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGS 378
K +S + P G EGHE AP + + +P +++G D T + + G
Sbjct: 767 KTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGP 826
Query: 379 PAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDG 438
+I R + ++ ++ P + Y +A+F+ D
Sbjct: 827 WGTGKIGENREKAAAASV------------------PNADGLKDSLYVAVADFEGD-KDT 867
Query: 439 ISFRGGQKAEVIDKNSGGWWYVQI----GEKEGWAPASYIDKRKKP 480
SF+ G EV +KNS GWW+ Q+ EGW P++Y+ RKKP
Sbjct: 868 SSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL--RKKP 911
Score = 45.4 bits (106), Expect = 3e-04
Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 150 ESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFV--- 206
E+ +K + A+ + YV V++++ +++ S Q G V +V EKN SGWWF
Sbjct: 834 ENREKAAAASVPNADGLKDSLYVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVL 892
Query: 207 -STSEEQGWVPATYL 220
+GW+P+ YL
Sbjct: 893 SGAPSWEGWIPSNYL 907
Score = 45.4 bits (106), Expect = 3e-04
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 5/60 (8%)
Query: 239 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGK----EGWAPASYLKK 294
++ YV V + KD F++G EV KN GWW+ + L EGW P++YL+K
Sbjct: 851 KDSLYVAVADFEGD-KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRK 909
Score = 37.7 bits (86), Expect = 0.061
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 5/54 (9%)
Query: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRF----GELEGWAPSHYL 866
Y+ + ++ +D+ SF G +V EK SGWW+ + EGW PS+YL
Sbjct: 855 YVAVADFEGDKDTS-SFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 907
Score = 37.4 bits (85), Expect = 0.079
Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 5/61 (8%)
Query: 1046 KDVYVSIADYEG-DEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKK 1104
++ Y I Y D++ + G +EV+++N GWW + + +GW P++YL+K
Sbjct: 223 EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRY----QGKEGWAPASYLKKN 278
Query: 1105 N 1105
+
Sbjct: 279 S 279
>gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens]
Length = 390
Score = 208 bits (529), Expect = 3e-53
Identities = 106/301 (35%), Positives = 171/301 (56%), Gaps = 12/301 (3%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
++ ++ EKR PS+HYVY+ V W D + + +YRR+++ ++ L + FPIE G
Sbjct: 6 IRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAI 65
Query: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125
+P+ RIIP LP F A R + EYC L+ LP IS+C + FF+ RP
Sbjct: 66 NPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRP 122
Query: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSEL 185
+D+ P ++ + K ++ + +S D+TG P+IL+ Y ++NY+K SE+
Sbjct: 123 DDLKLPTDNQ-TKKPETYLMPKDGKSTATDITG------PIILQTYRAIANYEKTSGSEM 175
Query: 186 SLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVT 245
+L G+VV+V+EK+ESGWWF ++GW+PA++LE + + D + G E YV
Sbjct: 176 ALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAG--EPYVA 233
Query: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
++ YT+ DE+ +G VEVI K L+GWW IR G+ P+ YL+K+ D+ ++
Sbjct: 234 IKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQ 293
Query: 306 L 306
+
Sbjct: 294 I 294
Score = 53.9 bits (128), Expect = 8e-07
Identities = 24/66 (36%), Positives = 37/66 (56%), Gaps = 4/66 (6%)
Query: 816 SYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL----VLDEN 871
+Y + Y+K SE++ G V+V+EK ESGWW+ + GW P+ +L DE
Sbjct: 160 TYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDET 219
Query: 872 EQPDPS 877
E P+P+
Sbjct: 220 EDPEPN 225
Score = 50.4 bits (119), Expect = 9e-06
Identities = 23/99 (23%), Positives = 43/99 (43%)
Query: 383 RIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFR 442
++ P ++ + N +P G P + Y IA ++ ++
Sbjct: 119 KVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALS 178
Query: 443 GGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPN 481
G EV++K+ GWW+ Q+ K GW PAS+++ P+
Sbjct: 179 TGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPD 217
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/58 (37%), Positives = 40/58 (68%), Gaps = 11/58 (18%)
Query: 1049 YVSIADYEGDEETAGFQEGVS----MEVLERNPNGWWYCQILDGVKPFKGWVPSNYLE 1102
Y +IA+YE +T+G + +S +EV+E++ +GWW+CQ +K +GW+P+++LE
Sbjct: 161 YRAIANYE---KTSGSEMALSTGDVVEVVEKSESGWWFCQ----MKAKRGWIPASFLE 211
Score = 44.7 bits (104), Expect = 5e-04
Identities = 23/69 (33%), Positives = 34/69 (49%), Gaps = 5/69 (7%)
Query: 803 PCPTKKEWEGPATSY-----MTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGEL 857
P + E E P +Y + AY V+ E+S G V+V+ K GWW +R ++
Sbjct: 212 PLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV 271
Query: 858 EGWAPSHYL 866
G+ PS YL
Sbjct: 272 TGYFPSMYL 280
Score = 43.5 bits (101), Expect = 0.001
Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 11/162 (6%)
Query: 416 PEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYID 475
PEP Y I + + D +S G+ EVI K GWW ++ + G+ P+ Y+
Sbjct: 222 PEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQ 281
Query: 476 KRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRK--LKYEEPEYDIP 533
K + ++S+ + R PP + + + SQD+ R+ +++ +
Sbjct: 282 KSGQ-DVSQAQRQIKR-GAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQA 339
Query: 534 AFGFDSEPELSEEPVEDRASGER---RPAQPHRPSPASSLQR 572
G P+ P+E+ +R +PA P RPS L R
Sbjct: 340 RPG----PQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNR 377
Score = 38.9 bits (89), Expect = 0.027
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 11/91 (12%)
Query: 1018 LPAQRNSIPVSPVRP--KPIEKSQFIHNNLKDVYVSIADY---EGDEETAGFQEGVSMEV 1072
+ A+R IP S + P P E N + YV+I Y EGDE EG ++EV
Sbjct: 198 MKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDE--VSLLEGEAVEV 255
Query: 1073 LERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
+ + +GWW + D G+ PS YL+K
Sbjct: 256 IHKLLDGWWVIRKDD----VTGYFPSMYLQK 282
>gi|41281811 NADPH oxidase organizer 1 isoform b [Homo sapiens]
Length = 371
Score = 96.3 bits (238), Expect = 1e-19
Identities = 73/292 (25%), Positives = 124/292 (42%), Gaps = 18/292 (6%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
VQ A +V +++ + + +V WSD + + R + +F L+ L + FP+E G
Sbjct: 10 VQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLL 63
Query: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125
R++P L L R + RL+ ++ Y R L+ +++ + FF +P
Sbjct: 64 RRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQP 123
Query: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSE- 184
D+ P V L + E P G + + + + + Q+ +
Sbjct: 124 LDLEP-----ALPPGSRVILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQPFCTQDTRDR 177
Query: 185 -LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYL-EAQNGTRDDSDINTSKTGEEE 241
QA E +DV+ ++ SGWW V + Q W PA YL EA G + + +G +
Sbjct: 178 PFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ- 236
Query: 242 KYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLK 293
+ + Y S DE+ G V V+ + GWW RY + G PA L+
Sbjct: 237 -FCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 287
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 15/107 (14%)
Query: 822 AYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKEL 881
AY+ + E+S PAG V+VLE + GWW R+G+ G P+ L +P+ G L
Sbjct: 242 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL------RPEGLGALL 295
Query: 882 DTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGG 928
+G + + +Q+ P +P++P G
Sbjct: 296 SGTGFRGGDDPA---------GEARGFPEPSQATAPPPTVPTRPSPG 333
Score = 38.9 bits (89), Expect = 0.027
Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 9/113 (7%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQ------ 223
Q+ Y+ ELS+ AG V V+E ++ GWW + G +PA L +
Sbjct: 236 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 295
Query: 224 NGT---RDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE 273
+GT D ++ E T P T ++ G + V R+ LE
Sbjct: 296 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALE 348
Score = 31.6 bits (70), Expect = 4.3
Identities = 13/35 (37%), Positives = 22/35 (62%), Gaps = 3/35 (8%)
Query: 1069 SMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
S++VL R+P+GWW +++ W P+ YLE+
Sbjct: 186 SLDVLLRHPSGWW---LVENEDRQTAWFPAPYLEE 217
>gi|41281828 NADPH oxidase organizer 1 isoform c [Homo sapiens]
Length = 376
Score = 94.4 bits (233), Expect = 5e-19
Identities = 74/297 (24%), Positives = 126/297 (42%), Gaps = 23/297 (7%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
VQ A +V +++ + + +V WSD + + R + +F L+ L + FP+E G
Sbjct: 10 VQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLL 63
Query: 66 DPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF 120
R++P L G+ L R + RL+ ++ Y R L+ +++ + F
Sbjct: 64 RRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGF 123
Query: 121 FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ 180
F +P D+ P V L + E P G + + + + + Q
Sbjct: 124 FAPQPLDLEP-----ALPPGSRVILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQPFCTQ 177
Query: 181 ENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYL-EAQNGTRDDSDINTSK 236
+ + QA E +DV+ ++ SGWW V + Q W PA YL EA G + +
Sbjct: 178 DTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGS 237
Query: 237 TGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLK 293
+G + + + Y S DE+ G V V+ + GWW RY + G PA L+
Sbjct: 238 SGPQ--FCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 292
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 15/107 (14%)
Query: 822 AYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKEL 881
AY+ + E+S PAG V+VLE + GWW R+G+ G P+ L +P+ G L
Sbjct: 247 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL------RPEGLGALL 300
Query: 882 DTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGG 928
+G + + +Q+ P +P++P G
Sbjct: 301 SGTGFRGGDDPA---------GEARGFPEPSQATAPPPTVPTRPSPG 338
Score = 38.9 bits (89), Expect = 0.027
Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 9/113 (7%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQ------ 223
Q+ Y+ ELS+ AG V V+E ++ GWW + G +PA L +
Sbjct: 241 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 300
Query: 224 NGT---RDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE 273
+GT D ++ E T P T ++ G + V R+ LE
Sbjct: 301 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALE 353
Score = 31.6 bits (70), Expect = 4.3
Identities = 13/35 (37%), Positives = 22/35 (62%), Gaps = 3/35 (8%)
Query: 1069 SMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
S++VL R+P+GWW +++ W P+ YLE+
Sbjct: 191 SLDVLLRHPSGWW---LVENEDRQTAWFPAPYLEE 222
>gi|21389405 NADPH oxidase organizer 1 isoform a [Homo sapiens]
Length = 370
Score = 92.0 bits (227), Expect = 3e-18
Identities = 73/292 (25%), Positives = 124/292 (42%), Gaps = 19/292 (6%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQK 65
VQ A +V +++ + + +V WSD + + R + +F L+ L + FP+E G
Sbjct: 10 VQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKETFPVEAGLL 62
Query: 66 DPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARP 125
R++P L L R + RL+ ++ Y R L+ +++ + FF +P
Sbjct: 63 RRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQP 122
Query: 126 EDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSE- 184
D+ P V L + E P G + + + + + Q+ +
Sbjct: 123 LDLEP-----ALPPGSRVILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQPFCTQDTRDR 176
Query: 185 -LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYL-EAQNGTRDDSDINTSKTGEEE 241
QA E +DV+ ++ SGWW V + Q W PA YL EA G + + +G +
Sbjct: 177 PFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQ- 235
Query: 242 KYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLK 293
+ + Y S DE+ G V V+ + GWW RY + G PA L+
Sbjct: 236 -FCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLR 286
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 15/107 (14%)
Query: 822 AYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKEL 881
AY+ + E+S PAG V+VLE + GWW R+G+ G P+ L +P+ G L
Sbjct: 241 AYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL------RPEGLGALL 294
Query: 882 DTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGG 928
+G + + +Q+ P +P++P G
Sbjct: 295 SGTGFRGGDDPA---------GEARGFPEPSQATAPPPTVPTRPSPG 332
Score = 38.9 bits (89), Expect = 0.027
Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 9/113 (7%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQ------ 223
Q+ Y+ ELS+ AG V V+E ++ GWW + G +PA L +
Sbjct: 235 QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALL 294
Query: 224 NGT---RDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE 273
+GT D ++ E T P T ++ G + V R+ LE
Sbjct: 295 SGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALE 347
Score = 31.6 bits (70), Expect = 4.3
Identities = 13/35 (37%), Positives = 22/35 (62%), Gaps = 3/35 (8%)
Query: 1069 SMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
S++VL R+P+GWW +++ W P+ YLE+
Sbjct: 185 SLDVLLRHPSGWW---LVENEDRQTAWFPAPYLEE 216
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 84.0 bits (206), Expect = 7e-16
Identities = 151/700 (21%), Positives = 260/700 (37%), Gaps = 146/700 (20%)
Query: 172 VVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYL----------- 220
+V +Y+ Q + EL++ GE++ I K + GWW + +G P ++
Sbjct: 5 IVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDP 64
Query: 221 -----------EAQNGT---RDDSDINTSKTGE--EEKYVTVQPYTSQSKDEIGFEKGVT 264
E +G ++ + T+K GE + Y Q+ DE+ + G
Sbjct: 65 LTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDI 124
Query: 265 VEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLN 324
+EV+ + EGWW GK G P++++K+ L+G + +G IS
Sbjct: 125 IEVVGEVEEGWWEGVLNGKTGMFPSNFIKE-----------LSGESDELG----ISQDEQ 169
Query: 325 KKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNG--SAVGVPDRTVSRLAQG---SP 379
S +ET +E +G ++ K E +NG + + + V + G
Sbjct: 170 LSKSSLRETTGSESDGGDSSSTKSE--------GANGTVATAAIQPKKVKGVGFGDIFKD 221
Query: 380 AVARIAPQRAQISSPNLRTRPPPRRESSLGFQLP---KPPEPPSVEVEYYT--------I 428
++ P+ ++ + L E ++G +LP P+ E++ T I
Sbjct: 222 KPIKLRPRSIEVENDFLPV------EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI 275
Query: 429 AEFQSCISDGISFRGGQKAEVIDKN--SGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRT 486
+++ D ++ + G +I+K+ GWW ++ + G P +++ K P+ +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KLLPPDFEKEG 334
Query: 487 STLTRPKVPPP--APPSK---------------PKEAEEGPTGASESQDSPRKLKYEEPE 529
+ RPK PPP AP K P E E +E ++ P + EP+
Sbjct: 335 N---RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER----EPK 387
Query: 530 YDIPAFGFDSEPELSEEPVEDRA---SGERRPAQPHRP----------SPASSLQRARFK 576
D+ + P P + + G P +P RP SP L +
Sbjct: 388 LDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLS 447
Query: 577 ------VGESSEDVALE--EETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKN 628
+ + S D+ LE + + E A G S S SSSLS
Sbjct: 448 GILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLS----- 502
Query: 629 SP---KSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSK 685
SP S SP+ K E + A G + +S S ++TI+ + +S +
Sbjct: 503 SPDIFDSPSPEED-----KEEHISLAHRGVD-ASKKTSKTVTISQVSDNKASLPPKPGTM 556
Query: 686 TSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKM 745
+G P S A AN+ KP + P A SQ+
Sbjct: 557 AAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEP-----AASSQAA--- 608
Query: 746 DISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSE 785
+ LR Q+R +LR ++ K + Q SE E
Sbjct: 609 -VEELRTQVR---ELRSIIETMKDQQKREIKQLLSELDEE 644
Score = 36.6 bits (83), Expect = 0.13
Identities = 48/198 (24%), Positives = 74/198 (37%), Gaps = 21/198 (10%)
Query: 751 RRQLRPTGQLRGGLKGSKSED--SELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKK 808
RR L P +R K K + ++ P + E PS S SS ++ T K
Sbjct: 44 RRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILR---------TNK 94
Query: 809 EWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVL 868
E +Y D E+ G ++V+ + E GWW G PS++ +
Sbjct: 95 RGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNF-IK 153
Query: 869 DENEQPDPSGKELDTVPAKGRQNE---GKSDSLEKIERRVQALNTVNQSKKATPPI-PSK 924
+ + + D G D +K E +SD + + + N AT I P K
Sbjct: 154 ELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGAN----GTVATAAIQPKK 209
Query: 925 PPG-GFGKTSGTPAVKMR 941
G GFG +K+R
Sbjct: 210 VKGVGFGDIFKDKPIKLR 227
Score = 34.3 bits (77), Expect = 0.67
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 1/79 (1%)
Query: 423 VEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNL 482
VE ++Q+ D ++ G+ I K GGWW QI + G P +++ + KK +
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKK-EM 60
Query: 483 SRRTSTLTRPKVPPPAPPS 501
+ T P+ P PS
Sbjct: 61 KKDPLTNKAPEKPLHEVPS 79
Score = 30.4 bits (67), Expect = 9.7
Identities = 11/44 (25%), Positives = 21/44 (47%)
Query: 823 YQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL 866
YQ D E++ G + + K++ GWW + G P +++
Sbjct: 10 YQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 67.0 bits (162), Expect = 9e-11
Identities = 36/136 (26%), Positives = 68/136 (50%), Gaps = 8/136 (5%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWW-----FVSTSEEQGWVPATYLEAQNGTR 227
V S Y + +LSL G+++ +++KN SGWW ++GW PA++++ +
Sbjct: 1033 VTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS- 1091
Query: 228 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA 287
S+ T + + + Y + ++DE+ F KG + V+ K+ WW G G
Sbjct: 1092 --SERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1149
Query: 288 PASYLKKAKDDLPTRK 303
P++Y+K D P+++
Sbjct: 1150 PSNYVKMTTDSDPSQQ 1165
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/349 (22%), Positives = 143/349 (40%), Gaps = 58/349 (16%)
Query: 146 SSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ--------ENSELSLQAGEVVDVIE 197
+SW + T + + P I Q VV N K Q +++ L+ +++ V+E
Sbjct: 844 TSWQKKSAFTRTVSPGSVSP-IHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE 902
Query: 198 KNESGWWFVSTSEEQGWVPATYLEAQNGT---RDDSD-----INTSKTGEE----EKYVT 245
+ E+ WWF +GW P +Y++ G+ R++ + +N T E+Y+
Sbjct: 903 QQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIA 961
Query: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
+ PY+S ++ F +G + V +K+ E WW + G P++Y+ K KD
Sbjct: 962 LYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYV-KPKDQ------- 1012
Query: 306 LAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVG 365
E G+ + S NKK + T G E ++SL + G +
Sbjct: 1013 -----ESFGSASK-SGASNKKPEIAQVTSAYVASGSE------QLSL------APGQLIL 1054
Query: 366 VPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEY 425
+ + S QG Q+ + +++ P ++ F P +V
Sbjct: 1055 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFH-------PVCQV-- 1105
Query: 426 YTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYI 474
+ ++ + D +SF GQ V++K+ WW +I G P++Y+
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1154
Score = 45.8 bits (107), Expect = 2e-04
Identities = 79/394 (20%), Positives = 136/394 (34%), Gaps = 102/394 (25%)
Query: 167 ILEQYVVVSNYKKQENSELSLQAGEVVDVIEKN--ESGWWFVSTSEEQGWVP-------- 216
+L Y + ++ + + E+S +G+++ V EK E GW + S GW P
Sbjct: 731 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 790
Query: 217 ------------------------------------ATYLEAQNGTRDDSDINTSKTGEE 240
A+ + QN + + +NTS +
Sbjct: 791 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 850
Query: 241 EKYVTVQP-----------------------YTSQSKDEIGFEKGVTVEVIRKNLEGWWY 277
TV P +T++ + + F K + V+ + E WW+
Sbjct: 851 AFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWF 909
Query: 278 IRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAE 337
G GW P SY+K R++ A + +NKK + +
Sbjct: 910 GEVHGGRGWFPKSYVKIIPGSEVKREEPEA-----------LYAAVNKKPTS---AAYSV 955
Query: 338 GEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLR 397
GE + A + P + G + V + G I + S ++
Sbjct: 956 GEEYIALYPYSSVE-PGDLTFTEGEEILVTQK------DGEWWTGSIGDRSGIFPSNYVK 1008
Query: 398 TRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGW 457
P+ + S G E+ T A S S+ +S GQ ++ KN+ GW
Sbjct: 1009 ----PKDQESFGSASKSGASNKKPEIAQVTSAYVASG-SEQLSLAPGQLILILKKNTSGW 1063
Query: 458 WYVQI---GEK--EGWAPASYIDKRKKPNLSRRT 486
W ++ G+K +GW PAS++ K P+ R T
Sbjct: 1064 WQGELQARGKKRQKGWFPASHV-KLLGPSSERAT 1096
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/119 (23%), Positives = 56/119 (47%), Gaps = 15/119 (12%)
Query: 178 KKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKT 237
K++E + LQ + + I++ E +EE+ L+A+ R+ + + +
Sbjct: 683 KEEEEKQKRLQEEKTQEKIQEEER------KAEEKQRKDKDTLKAEEKKRETASVLVN-- 734
Query: 238 GEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNL--EGWWYIRYLGKEGWAPASYLKK 294
Y + P+ +++ DE+ F G ++V K + GW Y + G GW P +Y++K
Sbjct: 735 -----YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 788
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/99 (24%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 813 PATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
P + Y + E+SF G + V+ K + WW + G PS+Y+ + +
Sbjct: 1101 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1160
Query: 873 QPDPSG----KELDTVPAKGRQNEGKSDSLEKIERRVQA 907
P + LDT+ R+ +G L + E R A
Sbjct: 1161 DPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMA 1199
Score = 40.0 bits (92), Expect = 0.012
Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 4/104 (3%)
Query: 414 KPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSG--GWWYVQIGEKEGWAPA 471
K E SV V Y + F++ D +SF G +V +K G GW Y GW P
Sbjct: 724 KKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 783
Query: 472 SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASE 515
+Y++ K P+ + + + PP P +++
Sbjct: 784 NYVE--KMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQ 825
Score = 38.1 bits (87), Expect = 0.046
Identities = 42/175 (24%), Positives = 78/175 (44%), Gaps = 29/175 (16%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD 229
Q + + +Y ELS G++++V+ K++ WW + G P+ Y++ D
Sbjct: 1104 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT----D 1159
Query: 230 SDINTSKTGEEEKYVTVQPYTS----------QSKDEIGFEKGVTVEVIRKNL------- 272
SD + + + T+QP Q+++ + + VEV +K +
Sbjct: 1160 SDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
Query: 273 EGWWYIRYLG-KEGWAPASYLKKAKDDLPTRKKNLAG--PVEIIGNIM--EISNL 322
EG + ++ KE + L KA L RKK PV++IG+I+ E+S++
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKA---LRVRKKTGGEKMPVQMIGDILAAELSHM 1271
Score = 36.2 bits (82), Expect = 0.18
Identities = 95/473 (20%), Positives = 157/473 (33%), Gaps = 62/473 (13%)
Query: 440 SFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRK----KPNLS---RRTSTLTRP 492
SFRGG++ + I+ + +Q E + P ++ DKRK + N+ RR + + +
Sbjct: 330 SFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQ 389
Query: 493 KVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRA 552
+ K KE E + Q+ ++L+ E+ + + EL + E+R
Sbjct: 390 QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR--------LEKQRELERQREEERR 441
Query: 553 SG-ERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSS 611
ERR A L+ R + E E+E I + L A
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGK 501
Query: 612 GDSDSPGSSSLSLTR---------------------KNSPKSGSPKSSSLLKLKAEKNAQ 650
S + L + K + + L+ L EK
Sbjct: 502 HQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLL 561
Query: 651 AEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKK 710
E KN FS NT S SL K + + DA + T ++
Sbjct: 562 NERIKN---MQFS-----NTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEM 613
Query: 711 DADANA-------------GLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPT 757
D+ N L + K + R E ++K++ R+ +
Sbjct: 614 DSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK 673
Query: 758 GQL--RGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPAT 815
L K + + L + E E R++ T K+E
Sbjct: 674 ENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLV 733
Query: 816 SYMTCSAYQKVQDSEISFPAGVEVQVLEKQ--ESGWWYVRFGELEGWAPSHYL 866
+Y ++ E+SF +G +QV EK E GW Y F GW P +Y+
Sbjct: 734 NYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 786
Score = 35.4 bits (80), Expect = 0.30
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 420 SVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKK 479
SV EY + + S ++F G++ V K+ G WW IG++ G P++Y+ + +
Sbjct: 954 SVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYVKPKDQ 1012
Query: 480 PNLSRRTSTLTRPKVP 495
+ + + K P
Sbjct: 1013 ESFGSASKSGASNKKP 1028
Score = 34.3 bits (77), Expect = 0.67
Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
Y+ Y V+ +++F G E+ V +K + WW G+ G PS+Y+ + E
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKPKDQE 1013
Score = 31.6 bits (70), Expect = 4.3
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 11/56 (19%)
Query: 821 SAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELE--------GWAPSHYLVL 868
SAY ++S G + +L+K SGWW GEL+ GW P+ ++ L
Sbjct: 1035 SAYVASGSEQLSLAPGQLILILKKNTSGWWQ---GELQARGKKRQKGWFPASHVKL 1087
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 67.0 bits (162), Expect = 9e-11
Identities = 36/136 (26%), Positives = 68/136 (50%), Gaps = 8/136 (5%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWW-----FVSTSEEQGWVPATYLEAQNGTR 227
V S Y + +LSL G+++ +++KN SGWW ++GW PA++++ +
Sbjct: 1060 VTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS- 1118
Query: 228 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA 287
S+ T + + + Y + ++DE+ F KG + V+ K+ WW G G
Sbjct: 1119 --SERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1176
Query: 288 PASYLKKAKDDLPTRK 303
P++Y+K D P+++
Sbjct: 1177 PSNYVKMTTDSDPSQQ 1192
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/349 (22%), Positives = 143/349 (40%), Gaps = 58/349 (16%)
Query: 146 SSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ--------ENSELSLQAGEVVDVIE 197
+SW + T + + P I Q VV N K Q +++ L+ +++ V+E
Sbjct: 871 TSWQKKSAFTRTVSPGSVSP-IHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE 929
Query: 198 KNESGWWFVSTSEEQGWVPATYLEAQNGT---RDDSD-----INTSKTGEE----EKYVT 245
+ E+ WWF +GW P +Y++ G+ R++ + +N T E+Y+
Sbjct: 930 QQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIA 988
Query: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
+ PY+S ++ F +G + V +K+ E WW + G P++Y+ K KD
Sbjct: 989 LYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYV-KPKDQ------- 1039
Query: 306 LAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVG 365
E G+ + S NKK + T G E ++SL + G +
Sbjct: 1040 -----ESFGSASK-SGASNKKPEIAQVTSAYVASGSE------QLSL------APGQLIL 1081
Query: 366 VPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEY 425
+ + S QG Q+ + +++ P ++ F P +V
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFH-------PVCQV-- 1132
Query: 426 YTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYI 474
+ ++ + D +SF GQ V++K+ WW +I G P++Y+
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1181
Score = 45.8 bits (107), Expect = 2e-04
Identities = 79/394 (20%), Positives = 136/394 (34%), Gaps = 102/394 (25%)
Query: 167 ILEQYVVVSNYKKQENSELSLQAGEVVDVIEKN--ESGWWFVSTSEEQGWVP-------- 216
+L Y + ++ + + E+S +G+++ V EK E GW + S GW P
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 817
Query: 217 ------------------------------------ATYLEAQNGTRDDSDINTSKTGEE 240
A+ + QN + + +NTS +
Sbjct: 818 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 877
Query: 241 EKYVTVQP-----------------------YTSQSKDEIGFEKGVTVEVIRKNLEGWWY 277
TV P +T++ + + F K + V+ + E WW+
Sbjct: 878 AFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWF 936
Query: 278 IRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAE 337
G GW P SY+K R++ A + +NKK + +
Sbjct: 937 GEVHGGRGWFPKSYVKIIPGSEVKREEPEA-----------LYAAVNKKPTS---AAYSV 982
Query: 338 GEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLR 397
GE + A + P + G + V + G I + S ++
Sbjct: 983 GEEYIALYPYSSVE-PGDLTFTEGEEILVTQK------DGEWWTGSIGDRSGIFPSNYVK 1035
Query: 398 TRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGW 457
P+ + S G E+ T A S S+ +S GQ ++ KN+ GW
Sbjct: 1036 ----PKDQESFGSASKSGASNKKPEIAQVTSAYVASG-SEQLSLAPGQLILILKKNTSGW 1090
Query: 458 WYVQI---GEK--EGWAPASYIDKRKKPNLSRRT 486
W ++ G+K +GW PAS++ K P+ R T
Sbjct: 1091 WQGELQARGKKRQKGWFPASHV-KLLGPSSERAT 1123
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/119 (23%), Positives = 56/119 (47%), Gaps = 15/119 (12%)
Query: 178 KKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKT 237
K++E + LQ + + I++ E +EE+ L+A+ R+ + + +
Sbjct: 710 KEEEEKQKRLQEEKTQEKIQEEER------KAEEKQRKDKDTLKAEEKKRETASVLVN-- 761
Query: 238 GEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNL--EGWWYIRYLGKEGWAPASYLKK 294
Y + P+ +++ DE+ F G ++V K + GW Y + G GW P +Y++K
Sbjct: 762 -----YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 815
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/99 (24%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 813 PATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
P + Y + E+SF G + V+ K + WW + G PS+Y+ + +
Sbjct: 1128 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 873 QPDPSG----KELDTVPAKGRQNEGKSDSLEKIERRVQA 907
P + LDT+ R+ +G L + E R A
Sbjct: 1188 DPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMA 1226
Score = 40.0 bits (92), Expect = 0.012
Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 4/104 (3%)
Query: 414 KPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSG--GWWYVQIGEKEGWAPA 471
K E SV V Y + F++ D +SF G +V +K G GW Y GW P
Sbjct: 751 KKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 472 SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASE 515
+Y++ K P+ + + + PP P +++
Sbjct: 811 NYVE--KMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQ 852
Score = 38.1 bits (87), Expect = 0.046
Identities = 42/175 (24%), Positives = 78/175 (44%), Gaps = 29/175 (16%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD 229
Q + + +Y ELS G++++V+ K++ WW + G P+ Y++ D
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT----D 1186
Query: 230 SDINTSKTGEEEKYVTVQPYTS----------QSKDEIGFEKGVTVEVIRKNL------- 272
SD + + + T+QP Q+++ + + VEV +K +
Sbjct: 1187 SDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
Query: 273 EGWWYIRYLG-KEGWAPASYLKKAKDDLPTRKKNLAG--PVEIIGNIM--EISNL 322
EG + ++ KE + L KA L RKK PV++IG+I+ E+S++
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKA---LRVRKKTGGEKMPVQMIGDILAAELSHM 1298
Score = 35.4 bits (80), Expect = 0.30
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 420 SVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKK 479
SV EY + + S ++F G++ V K+ G WW IG++ G P++Y+ + +
Sbjct: 981 SVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYVKPKDQ 1039
Query: 480 PNLSRRTSTLTRPKVP 495
+ + + K P
Sbjct: 1040 ESFGSASKSGASNKKP 1055
Score = 34.7 bits (78), Expect = 0.51
Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 2/104 (1%)
Query: 765 KGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQ 824
K + + L + E E R++ T K+E +Y ++
Sbjct: 710 KEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFE 769
Query: 825 KVQDSEISFPAGVEVQVLEKQ--ESGWWYVRFGELEGWAPSHYL 866
E+SF +G +QV EK E GW Y F GW P +Y+
Sbjct: 770 ARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 813
Score = 34.3 bits (77), Expect = 0.67
Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
Y+ Y V+ +++F G E+ V +K + WW G+ G PS+Y+ + E
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKPKDQE 1040
Score = 31.6 bits (70), Expect = 4.3
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 11/56 (19%)
Query: 821 SAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELE--------GWAPSHYLVL 868
SAY ++S G + +L+K SGWW GEL+ GW P+ ++ L
Sbjct: 1062 SAYVASGSEQLSLAPGQLILILKKNTSGWWQ---GELQARGKKRQKGWFPASHVKL 1114
Score = 30.8 bits (68), Expect = 7.4
Identities = 37/160 (23%), Positives = 65/160 (40%), Gaps = 16/160 (10%)
Query: 440 SFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRK----KPNL---SRRTSTLTRP 492
SFRGG++ + I+ + +Q E + P ++ DKRK + N+ RR + + +
Sbjct: 330 SFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQ 389
Query: 493 KVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRA 552
+ K KE E + Q+ ++L+ E+ + + EL + E+R
Sbjct: 390 QREAERKAQKEKEEWERKQRELQEQEWKKQLELEK--------RLEKQRELERQREEERR 441
Query: 553 SG-ERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETI 591
ERR A L+ R + E E+E I
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 67.0 bits (162), Expect = 9e-11
Identities = 36/136 (26%), Positives = 68/136 (50%), Gaps = 8/136 (5%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWW-----FVSTSEEQGWVPATYLEAQNGTR 227
V S Y + +LSL G+++ +++KN SGWW ++GW PA++++ +
Sbjct: 1060 VTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS- 1118
Query: 228 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA 287
S+ T + + + Y + ++DE+ F KG + V+ K+ WW G G
Sbjct: 1119 --SERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1176
Query: 288 PASYLKKAKDDLPTRK 303
P++Y+K D P+++
Sbjct: 1177 PSNYVKMTTDSDPSQQ 1192
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/349 (22%), Positives = 143/349 (40%), Gaps = 58/349 (16%)
Query: 146 SSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ--------ENSELSLQAGEVVDVIE 197
+SW + T + + P I Q VV N K Q +++ L+ +++ V+E
Sbjct: 871 TSWQKKSAFTRTVSPGSVSP-IHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE 929
Query: 198 KNESGWWFVSTSEEQGWVPATYLEAQNGT---RDDSD-----INTSKTGEE----EKYVT 245
+ E+ WWF +GW P +Y++ G+ R++ + +N T E+Y+
Sbjct: 930 QQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIA 988
Query: 246 VQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKN 305
+ PY+S ++ F +G + V +K+ E WW + G P++Y+ K KD
Sbjct: 989 LYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYV-KPKDQ------- 1039
Query: 306 LAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVG 365
E G+ + S NKK + T G E ++SL + G +
Sbjct: 1040 -----ESFGSASK-SGASNKKPEIAQVTSAYVASGSE------QLSL------APGQLIL 1081
Query: 366 VPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEY 425
+ + S QG Q+ + +++ P ++ F P +V
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFH-------PVCQV-- 1132
Query: 426 YTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYI 474
+ ++ + D +SF GQ V++K+ WW +I G P++Y+
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1181
Score = 45.8 bits (107), Expect = 2e-04
Identities = 79/394 (20%), Positives = 136/394 (34%), Gaps = 102/394 (25%)
Query: 167 ILEQYVVVSNYKKQENSELSLQAGEVVDVIEKN--ESGWWFVSTSEEQGWVP-------- 216
+L Y + ++ + + E+S +G+++ V EK E GW + S GW P
Sbjct: 758 VLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 817
Query: 217 ------------------------------------ATYLEAQNGTRDDSDINTSKTGEE 240
A+ + QN + + +NTS +
Sbjct: 818 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 877
Query: 241 EKYVTVQP-----------------------YTSQSKDEIGFEKGVTVEVIRKNLEGWWY 277
TV P +T++ + + F K + V+ + E WW+
Sbjct: 878 AFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWF 936
Query: 278 IRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAE 337
G GW P SY+K R++ A + +NKK + +
Sbjct: 937 GEVHGGRGWFPKSYVKIIPGSEVKREEPEA-----------LYAAVNKKPTS---AAYSV 982
Query: 338 GEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLR 397
GE + A + P + G + V + G I + S ++
Sbjct: 983 GEEYIALYPYSSVE-PGDLTFTEGEEILVTQK------DGEWWTGSIGDRSGIFPSNYVK 1035
Query: 398 TRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGW 457
P+ + S G E+ T A S S+ +S GQ ++ KN+ GW
Sbjct: 1036 ----PKDQESFGSASKSGASNKKPEIAQVTSAYVASG-SEQLSLAPGQLILILKKNTSGW 1090
Query: 458 WYVQI---GEK--EGWAPASYIDKRKKPNLSRRT 486
W ++ G+K +GW PAS++ K P+ R T
Sbjct: 1091 WQGELQARGKKRQKGWFPASHV-KLLGPSSERAT 1123
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/119 (23%), Positives = 56/119 (47%), Gaps = 15/119 (12%)
Query: 178 KKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKT 237
K++E + LQ + + I++ E +EE+ L+A+ R+ + + +
Sbjct: 710 KEEEEKQKRLQEEKTQEKIQEEER------KAEEKQRKDKDTLKAEEKKRETASVLVN-- 761
Query: 238 GEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNL--EGWWYIRYLGKEGWAPASYLKK 294
Y + P+ +++ DE+ F G ++V K + GW Y + G GW P +Y++K
Sbjct: 762 -----YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 815
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/99 (24%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 813 PATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
P + Y + E+SF G + V+ K + WW + G PS+Y+ + +
Sbjct: 1128 PVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 873 QPDPSG----KELDTVPAKGRQNEGKSDSLEKIERRVQA 907
P + LDT+ R+ +G L + E R A
Sbjct: 1188 DPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMA 1226
Score = 40.0 bits (92), Expect = 0.012
Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 4/104 (3%)
Query: 414 KPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSG--GWWYVQIGEKEGWAPA 471
K E SV V Y + F++ D +SF G +V +K G GW Y GW P
Sbjct: 751 KKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 472 SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASE 515
+Y++ K P+ + + + PP P +++
Sbjct: 811 NYVE--KMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQ 852
Score = 37.4 bits (85), Expect = 0.079
Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD 229
Q + + +Y ELS G++++V+ K++ WW + G P+ Y++ D
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT----D 1186
Query: 230 SDINTSKTGEEEKYVTVQP 248
SD + + + T+QP
Sbjct: 1187 SDPSQQWCADLQTLDTMQP 1205
Score = 35.4 bits (80), Expect = 0.30
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 420 SVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKK 479
SV EY + + S ++F G++ V K+ G WW IG++ G P++Y+ + +
Sbjct: 981 SVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGDRSGIFPSNYVKPKDQ 1039
Query: 480 PNLSRRTSTLTRPKVP 495
+ + + K P
Sbjct: 1040 ESFGSASKSGASNKKP 1055
Score = 34.7 bits (78), Expect = 0.51
Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 2/104 (1%)
Query: 765 KGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQ 824
K + + L + E E R++ T K+E +Y ++
Sbjct: 710 KEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFE 769
Query: 825 KVQDSEISFPAGVEVQVLEKQ--ESGWWYVRFGELEGWAPSHYL 866
E+SF +G +QV EK E GW Y F GW P +Y+
Sbjct: 770 ARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYV 813
Score = 34.3 bits (77), Expect = 0.67
Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 817 YMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE 872
Y+ Y V+ +++F G E+ V +K + WW G+ G PS+Y+ + E
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKPKDQE 1040
Score = 31.6 bits (70), Expect = 4.3
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 11/56 (19%)
Query: 821 SAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELE--------GWAPSHYLVL 868
SAY ++S G + +L+K SGWW GEL+ GW P+ ++ L
Sbjct: 1062 SAYVASGSEQLSLAPGQLILILKKNTSGWWQ---GELQARGKKRQKGWFPASHVKL 1114
Score = 30.8 bits (68), Expect = 7.4
Identities = 37/160 (23%), Positives = 65/160 (40%), Gaps = 16/160 (10%)
Query: 440 SFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRK----KPNL---SRRTSTLTRP 492
SFRGG++ + I+ + +Q E + P ++ DKRK + N+ RR + + +
Sbjct: 330 SFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQ 389
Query: 493 KVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRA 552
+ K KE E + Q+ ++L+ E+ + + EL + E+R
Sbjct: 390 QREAERKAQKEKEEWERKQRELQEQEWKKQLELEK--------RLEKQRELERQREEERR 441
Query: 553 SG-ERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETI 591
ERR A L+ R + E E+E I
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 65.1 bits (157), Expect = 4e-10
Identities = 90/455 (19%), Positives = 170/455 (37%), Gaps = 106/455 (23%)
Query: 171 YVVVSNYKKQENSELSLQAGEVVDVIEK-NESGWWFVSTSEEQGWVPATY---LEAQNGT 226
Y+V +Y + EL+++ GE++ ++K E GW + +G P + ++ +
Sbjct: 4 YIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEF 63
Query: 227 RDDS-DINTSKTGEEEKYVT-----------VQP---------------------YTSQS 253
+DDS I + G V +QP Y Q+
Sbjct: 64 KDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQN 123
Query: 254 KDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKK-----------AKDDLPTR 302
+DE+ + G +++ + EGWW K G P++++K+ A+DD T
Sbjct: 124 EDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETV 183
Query: 303 KKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGS 362
P+ +GN+ E ASG T P + G KE S+ + S+
Sbjct: 184 LAGPTSPIPSLGNVSET-------ASGSV-TQPKKIRGIGFGDIFKEGSVKLRTRTSSSE 235
Query: 363 AVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVE 422
+ + P + P+ +S ++ K ++
Sbjct: 236 T-----------------------EEKKPEKPLILQSLGPKTQS---VEITKTDTEGKIK 269
Query: 423 VEYY--TIAEFQSCISDGISFRGGQKAEVIDKNSG--GWWYVQIGEKEGWAPASYIDKRK 478
+ Y T+ ++ D ++F+ G+ +I K +G GWW ++ KEG P ++
Sbjct: 270 AKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNF----- 324
Query: 479 KPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFD 538
++ +PK PPP A P + E+ + + D
Sbjct: 325 AVQINELDKDFPKPKKPPPP--------------AKAPAPKPELIAAEKKYFSLKPEEKD 370
Query: 539 SEPELSEEPVEDRASGERRPAQPHRPSPASSLQRA 573
+ L ++P + A+ + P +P P+ AS+L R+
Sbjct: 371 EKSTLEQKPSKP-AAPQVPPKKPTPPTKASNLLRS 404
Score = 51.6 bits (122), Expect = 4e-06
Identities = 56/220 (25%), Positives = 88/220 (40%), Gaps = 37/220 (16%)
Query: 758 GQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSY 817
G ++ + S SE E P+ S G + S ++ TK + EG +
Sbjct: 223 GSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEI-----------TKTDTEGKIKAK 271
Query: 818 MTCS---AYQKVQDSEISFPAGVEVQVLEKQ--ESGWWYVRFGELEGWAPSHYLV-LDEN 871
C AY+ + E++F G + ++ K+ E+GWW EG P ++ V ++E
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
Query: 872 EQPDPSGKELDTVPAKGR-------QNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSK 924
++ P K+ PAK E K SL+ E+ ++ SK A P +P K
Sbjct: 332 DKDFPKPKK-PPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPK 390
Query: 925 PPGGFGKTSGTPAVKMRNGVRQVAV----RPQSVFVSPPP 960
P TP K N +R RP+ PPP
Sbjct: 391 KP--------TPPTKASNLLRSSGTVYPKRPEKPVPPPPP 422
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/71 (28%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD 229
Q V+ Y Q EL L+ G+++D+ E+ E GWW + + + G P+ +++ T DD
Sbjct: 112 QCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT-DD 170
Query: 230 SDINTSKTGEE 240
+ + ++ E
Sbjct: 171 GETHEAQDDSE 181
Score = 33.5 bits (75), Expect = 1.1
Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 17/123 (13%)
Query: 823 YQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELD 882
Y + E+ G + + E+ E GWW G PS+++ KEL+
Sbjct: 119 YIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFV------------KELE 166
Query: 883 TVPAKGRQNEGKSDS---LEKIERRVQALNTVNQSKKATPPIPSKPPG-GFGKTSGTPAV 938
V G +E + DS L + +L V+++ + P K G GFG +V
Sbjct: 167 -VTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSV 225
Query: 939 KMR 941
K+R
Sbjct: 226 KLR 228
Score = 31.6 bits (70), Expect = 4.3
Identities = 16/67 (23%), Positives = 31/67 (46%), Gaps = 2/67 (2%)
Query: 155 DVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKN--ESGWWFVSTSEEQ 212
++T D + E + Y+ EL+ + GE++ +I K E+GWW + ++
Sbjct: 258 EITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE 317
Query: 213 GWVPATY 219
G P +
Sbjct: 318 GVFPDNF 324
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 65.1 bits (157), Expect = 4e-10
Identities = 135/615 (21%), Positives = 228/615 (37%), Gaps = 121/615 (19%)
Query: 232 INTSKTGEEEKY--VTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPA 289
+ T+K GE + Y Q+ DE+ + G +EV+ + EGWW GK G P+
Sbjct: 53 LRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPS 112
Query: 290 SYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKE 349
+++K+ L+G + +G IS S +ET +E +G ++ K E
Sbjct: 113 NFIKE-----------LSGESDELG----ISQDEQLSKSSLRETTGSESDGGDSSSTKSE 157
Query: 350 ISLPILCNASNG--SAVGVPDRTVSRLAQG---SPAVARIAPQRAQISSPNLRTRPPPRR 404
+NG + + + V + G ++ P+ ++ + L
Sbjct: 158 --------GANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV------ 203
Query: 405 ESSLGFQLP---KPPEPPSVEVEYYT--------IAEFQSCISDGISFRGGQKAEVIDKN 453
E ++G +LP P+ E++ T I +++ D ++ + G +I+K+
Sbjct: 204 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 263
Query: 454 --SGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPP--APPSK------- 502
GWW ++ + G P +++ K P+ + + RPK PPP AP K
Sbjct: 264 CIDVGWWEGELNGRRGVFPDNFV-KLLPPDFEKEGN---RPKKPPPPSAPVIKQGAGTTE 319
Query: 503 --------PKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRA-- 552
P E E +E ++ P + EP+ D+ + P P + +
Sbjct: 320 RKHEIKKIPPERPEMLPNRTEEKERPER----EPKLDLQKPSVPAIPPKKPRPPKTNSLS 375
Query: 553 -SGERRPAQPHRP----------SPASSLQRARFK------VGESSEDVALE--EETIYE 593
G P +P RP SP L + + + S D+ LE + +
Sbjct: 376 RPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSS 435
Query: 594 NEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSP---KSGSPKSSSLLKLKAEKNAQ 650
E A G S S SSSLS SP S SP+ K E +
Sbjct: 436 TEKLSHPTTSRPKATGRRPPSQSLTSSSLS-----SPDIFDSPSPEED-----KEEHISL 485
Query: 651 AEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKK 710
A G + +S S ++TI+ + +S + +G P S A
Sbjct: 486 AHRGVD-ASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTA 544
Query: 711 DADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSE 770
AN+ KP + P A SQ+ + LR Q+R +LR ++ K +
Sbjct: 545 GHRANSPSLFGTEGKPKMEP-----AASSQAA----VEELRTQVR---ELRSIIETMKDQ 592
Query: 771 DSELPPQTASEAPSE 785
Q SE E
Sbjct: 593 QKREIKQLLSELDEE 607
Score = 43.5 bits (101), Expect = 0.001
Identities = 105/524 (20%), Positives = 180/524 (34%), Gaps = 90/524 (17%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRD---- 228
V +Y Q + EL L+ G++++V+ + E GWW + + G P+ +++ +G D
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGI 127
Query: 229 --DSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGW 286
D ++ S E + +S +K E T + K ++G +
Sbjct: 128 SQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGF--------- 178
Query: 287 APASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIA 346
K L R +E+ + + + + KK TP + ++
Sbjct: 179 --GDIFKDKPIKLRPRS------IEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTK 230
Query: 347 KKEISLPIL-CNASNGSAVGVPDRTVSRLAQGSPA-----VARIAPQRAQISSPNLRTRP 400
K+ I A N + + + + L + +R ++ P
Sbjct: 231 SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 290
Query: 401 PPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYV 460
P + PK P PPS V + I ++ E++ +
Sbjct: 291 PDFEKEG---NRPKKPPPPSAPVIKQGAGTTER--KHEIKKIPPERPEMLPNRT------ 339
Query: 461 QIGEKEGWAPASYIDKRKKPNLSRR------TSTLTRPKVPPPAPPSKPKEAEEGPTG-- 512
+ E+ P + K P + + T++L+RP PP P +P G
Sbjct: 340 EEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDS 399
Query: 513 -----ASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEE---PVEDR--ASGERRPAQP- 561
A S + DI GFDS +E+ P R A+G R P+Q
Sbjct: 400 PKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSL 459
Query: 562 -----------HRPSP-------ASSLQRARFKVGESSEDVALEEETIYENEGFRPYAED 603
PSP S R ++S+ V + + + +N+ P
Sbjct: 460 TSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQ--VSDNKASLPPKPG 517
Query: 604 TLSARGS-----SGDSDSPGSSSLSLT--RKNSPK----SGSPK 636
T++A G S + SP SSSL R NSP G PK
Sbjct: 518 TMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPK 561
Score = 34.7 bits (78), Expect = 0.51
Identities = 41/175 (23%), Positives = 65/175 (37%), Gaps = 19/175 (10%)
Query: 772 SELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEI 831
++ P + E PS S SS ++ T K E +Y D E+
Sbjct: 30 NKAPEKPLHEVPSGNSLLSSETILR---------TNKRGERRRRRCQVAFSYLPQNDDEL 80
Query: 832 SFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQN 891
G ++V+ + E GWW G PS++ + + + + D G D +K
Sbjct: 81 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNF-IKELSGESDELGISQDEQLSKSSLR 139
Query: 892 E---GKSDSLEKIERRVQALNTVNQSKKATPPI-PSKPPG-GFGKTSGTPAVKMR 941
E +SD + + + N AT I P K G GFG +K+R
Sbjct: 140 ETTGSESDGGDSSSTKSEGAN----GTVATAAIQPKKVKGVGFGDIFKDKPIKLR 190
>gi|47519798 neutrophil cytosolic factor 4 isoform 1 [Homo sapiens]
Length = 339
Score = 64.7 bits (156), Expect = 5e-10
Identities = 50/223 (22%), Positives = 98/223 (43%), Gaps = 11/223 (4%)
Query: 9 ATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPK 68
A + D+E++R + H+V++I V + IYRRY +F LQ +L ++F + +
Sbjct: 24 ANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPD-SKSSAL 82
Query: 69 QRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDV 128
+P LP K+ +++A R+ ++ Y ++L+ LP + ++V FF P D
Sbjct: 83 ACTLPTLPAKVYVGVK--QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYD- 139
Query: 129 NPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQ 188
E + R+ + +S D A P + N K EL+ +
Sbjct: 140 ---SEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSK----LELNFK 192
Query: 189 AGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSD 231
AG+V+ ++ + W + G P ++++ ++ D
Sbjct: 193 AGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDD 235
>gi|163644267 neutrophil cytosolic factor 4 isoform 2 [Homo sapiens]
Length = 348
Score = 64.7 bits (156), Expect = 5e-10
Identities = 50/223 (22%), Positives = 98/223 (43%), Gaps = 11/223 (4%)
Query: 9 ATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPK 68
A + D+E++R + H+V++I V + IYRRY +F LQ +L ++F + +
Sbjct: 24 ANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPD-SKSSAL 82
Query: 69 QRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDV 128
+P LP K+ +++A R+ ++ Y ++L+ LP + ++V FF P D
Sbjct: 83 ACTLPTLPAKVYVGVK--QEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYD- 139
Query: 129 NPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQ 188
E + R+ + +S D A P + N K EL+ +
Sbjct: 140 ---SEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSK----LELNFK 192
Query: 189 AGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSD 231
AG+V+ ++ + W + G P ++++ ++ D
Sbjct: 193 AGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDD 235
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 63.5 bits (153), Expect = 1e-09
Identities = 41/132 (31%), Positives = 64/132 (48%), Gaps = 15/132 (11%)
Query: 176 NYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGT--------- 226
NY + ELSL G V V+EK GWW S + + GW P+ Y+ + +
Sbjct: 116 NYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSL 175
Query: 227 --RDDSDINTSKTGEEEKYV-TVQPYTSQSKDEIGFEKGVTVEVIRK--NLEGWWYIRYL 281
+ + +N TG+ V + P++S + +E+ FEKG ++VI K N WW R +
Sbjct: 176 SEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKI 235
Query: 282 -GKEGWAPASYL 292
G G P +Y+
Sbjct: 236 NGMVGLVPKNYV 247
Score = 62.0 bits (149), Expect = 3e-09
Identities = 60/265 (22%), Positives = 114/265 (43%), Gaps = 45/265 (16%)
Query: 169 EQYVVVS--NYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGT 226
E+ VVV+ +Y Q+ EL ++ E + +++ ++S W ++ + G+VP+ Y+E +N
Sbjct: 3 EEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSA 62
Query: 227 RDDSDINTSKT----GEEEKYVTVQP----------------------------YTSQSK 254
R S + K G+ ++ +V Y ++ +
Sbjct: 63 RKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAERE 122
Query: 255 DEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD-----LPTRKKNLAGP 309
DE+ KG V V+ K +GWW Y G+ GW P++Y+ + D + + + LA
Sbjct: 123 DELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAV 182
Query: 310 VEII--GNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLP--ILCNASNGSAVG 365
V + G ++ + L +S + E E +G + +K + P C NG VG
Sbjct: 183 VNNLNTGQVLHVVQALYPFSSSNDEELNFE-KGDVMDVIEKPENDPEWWKCRKING-MVG 240
Query: 366 VPDRTVSRLAQGSPAVARIAPQRAQ 390
+ + + Q +P + + P Q
Sbjct: 241 LVPKNYVTVMQNNPLTSGLEPSPPQ 265
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 823 YQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQP 874
Y ++ E+S G +V V+EK GWW + GW PS+Y V +E + P
Sbjct: 117 YMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNY-VTEEGDSP 167
Score = 35.0 bits (79), Expect = 0.39
Identities = 16/54 (29%), Positives = 26/54 (48%)
Query: 437 DGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLT 490
D +S G K V++K S GWW + GW P++Y+ + L +L+
Sbjct: 123 DELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLS 176
Score = 31.6 bits (70), Expect = 4.3
Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 6/86 (6%)
Query: 1021 QRNSIP--VSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPN 1078
++ S+P SP ++ + +++ YV E+ +G + V+E+ +
Sbjct: 82 RKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSD 141
Query: 1079 GWWYCQILDGVKPFKGWVPSNYLEKK 1104
GWW V GW PSNY+ ++
Sbjct: 142 GWWRGSYNGQV----GWFPSNYVTEE 163
Score = 30.4 bits (67), Expect = 9.7
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 4/61 (6%)
Query: 823 YQKVQDSEISFPAGVEVQVLEKQESG--WWYVR-FGELEGWAPSHYLVLDENEQPDPSGK 879
+ D E++F G + V+EK E+ WW R + G P +Y+ + +N P SG
Sbjct: 201 FSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQN-NPLTSGL 259
Query: 880 E 880
E
Sbjct: 260 E 260
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/140 (26%), Positives = 68/140 (48%), Gaps = 9/140 (6%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWW-----FVSTSEEQGWVPATYLEAQN-GT 226
V+++Y +L+L G+++ + +KN GWW + GW PA Y++ + GT
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 227 RDDSDINTSKTGEEE---KYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGK 283
+ K+ + + + YT+Q+ DE+ F KG + V+ K WW G+
Sbjct: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
Query: 284 EGWAPASYLKKAKDDLPTRK 303
G P++Y+K D P+++
Sbjct: 1201 VGLFPSNYVKLTTDMDPSQQ 1220
Score = 57.4 bits (137), Expect = 7e-08
Identities = 65/319 (20%), Positives = 136/319 (42%), Gaps = 54/319 (16%)
Query: 177 YKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSK 236
++ ++++ L+ +V+ V+E+ + WWF ++GW P +Y++ +G S S
Sbjct: 924 WRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSG 982
Query: 237 TGEE------------------EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYI 278
+ E E+++ + Y S + ++ F++G + V +K+ + WW
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTG 1041
Query: 279 RYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLL-NKKASGDKETPPAE 337
K G P++Y+ + KD + AG +G EI+ ++ + A+G ++ A
Sbjct: 1042 TVGDKAGVFPSNYV-RLKD---SEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAP 1097
Query: 338 GEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPA--VARIAPQRAQISSPN 395
G+ I KK N + R R PA V ++P ++I+
Sbjct: 1098 GQ--LILIRKK--------NPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITP-- 1145
Query: 396 LRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSG 455
T PP + ++L + + + ++ + D ++F GQ V++K
Sbjct: 1146 --TEPP--KSTAL-----------AAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDP 1190
Query: 456 GWWYVQIGEKEGWAPASYI 474
WW ++ + G P++Y+
Sbjct: 1191 DWWKGEVNGQVGLFPSNYV 1209
Score = 47.8 bits (112), Expect = 6e-05
Identities = 106/508 (20%), Positives = 179/508 (35%), Gaps = 82/508 (16%)
Query: 420 SVEVEYY-TIAEFQSCISDGISFRGGQ----KAEVIDKNSGG---WWYVQIGEKEGWAPA 471
+V+V YY + F+S D I+ + G K E +D++ G W ++ K GW PA
Sbjct: 739 NVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPA 798
Query: 472 SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYD 531
+Y +K + +VP P P + P A +P + EP
Sbjct: 799 NYAEK------------IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTT 846
Query: 532 IPAFG-FDSEPELSEEPVEDRASGERRPAQPHR--PSPASSLQRARFK------------ 576
+ F S S + + + AQP PS QR+ F
Sbjct: 847 PNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPV 906
Query: 577 VGESSEDVALEEETIY-------------ENEGFRPYAEDTL----SARGSSGDSDSPGS 619
+G+ + L+ + +Y +N+ + + +G G
Sbjct: 907 LGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYV 966
Query: 620 SSLS--LTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSS 677
+S + + S SGS +S + LK A A+ + S F + T ++ +
Sbjct: 967 KLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVV----SGEEFIAMYTYESSEQGDLT 1022
Query: 678 SSSSSL---SKTSGDLKPRSASD-AGIRGTPKVRAK-KDADANAGLTSCPRAKPSVRPKP 732
+ +K GD + D AG+ + VR K + AG T KP +
Sbjct: 1023 FQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ-- 1080
Query: 733 FLNRAESQSQEKMDIST----LRRQLRPTGQLRGGL--KGSKSEDSELPPQTASEAPSEG 786
+ + E++ ++ L R+ P G G L +G K + P + S G
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV-KLLSPG 1139
Query: 787 SRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQE 846
+ + TP P K + Y D E++F G + VL K++
Sbjct: 1140 TSK----------ITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKED 1189
Query: 847 SGWWYVRFGELEGWAPSHYLVLDENEQP 874
WW G PS+Y+ L + P
Sbjct: 1190 PDWWKGEVNGQVGLFPSNYVKLTTDMDP 1217
Score = 45.1 bits (105), Expect = 4e-04
Identities = 59/266 (22%), Positives = 100/266 (37%), Gaps = 42/266 (15%)
Query: 238 GEEEKYVTVQ-----PYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL 292
G+ EK +Q P+ ++ + + F K + V+ + + WW+ G++GW P SY+
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYV 966
Query: 293 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL 352
K + +G E ++ K+ + P GE A +
Sbjct: 967 KLISGPIRKSTSMDSGSSESPASL--------KRVASPAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 353 PILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPR-----RESS 407
L G + V + G + + S +R + + S
Sbjct: 1019 GDL-TFQQGDVILVTKK------DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGS 1071
Query: 408 LGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQI---GE 464
LG K PE V IA + + + ++ GQ + KN GGWW ++ G+
Sbjct: 1072 LG----KKPEIAQV------IASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGK 1121
Query: 465 KE--GWAPASYIDKRKKPNLSRRTST 488
K GW PA+Y+ K P S+ T T
Sbjct: 1122 KRQIGWFPANYV-KLLSPGTSKITPT 1146
Score = 37.4 bits (85), Expect = 0.079
Identities = 13/52 (25%), Positives = 29/52 (55%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLE 221
Q + + +Y Q + EL+ G++++V+ K + WW + + G P+ Y++
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 37.0 bits (84), Expect = 0.10
Identities = 70/387 (18%), Positives = 126/387 (32%), Gaps = 61/387 (15%)
Query: 115 DEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVV 174
D++ R F E P + + W+ + K +T + E + + Y +
Sbjct: 703 DKLGRLFHQHQEPAKPAVQ------------APWSTAEKGPLT--ISAQENVKVVYYRAL 748
Query: 175 SNYKKQENSELSLQAGEVV-------DVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTR 227
++ + + E+++Q G++V D + E GW + GW PA Y E
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE------ 802
Query: 228 DDSDINTSKTGEEEKYVTVQPYTSQSK--------DEIGFEKGVTVEVIRKNLEGWWYIR 279
K E E V+P T + E VT W
Sbjct: 803 --------KIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADF- 853
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGE 339
W ++ K D+ + V G + + S A+G + P G+
Sbjct: 854 ---SSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPS-PVLGQ 909
Query: 340 GHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRA--------QI 391
G + + + P N D Q + Q+ I
Sbjct: 910 GEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLI 969
Query: 392 SSPNLRTRPPPRRESSLGFQLPKPPEPPSVEV----EYYTIAEFQSCISDGISFRGGQKA 447
S P ++ S L + P + V E+ + ++S ++F+ G
Sbjct: 970 SGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-V 1028
Query: 448 EVIDKNSGGWWYVQIGEKEGWAPASYI 474
++ K G WW +G+K G P++Y+
Sbjct: 1029 ILVTKKDGDWWTGTVGDKAGVFPSNYV 1055
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 11/106 (10%)
Query: 776 PQTASEAPSEGSRRSSSDL--ITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISF 833
P S + GS S + L + PA P ++ ++ Y+ + +++F
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEE--------FIAMYTYESSEQGDLTF 1023
Query: 834 PAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGK 879
G +V ++ K++ WW G+ G PS+Y+ L ++E +GK
Sbjct: 1024 QQG-DVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGK 1068
Score = 31.2 bits (69), Expect = 5.7
Identities = 12/32 (37%), Positives = 20/32 (62%), Gaps = 1/32 (3%)
Query: 1072 VLERNPNGWWYCQI-LDGVKPFKGWVPSNYLE 1102
+ ++NP GWW ++ G K GW P+NY++
Sbjct: 1103 IRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/140 (26%), Positives = 68/140 (48%), Gaps = 9/140 (6%)
Query: 173 VVSNYKKQENSELSLQAGEVVDVIEKNESGWW-----FVSTSEEQGWVPATYLEAQN-GT 226
V+++Y +L+L G+++ + +KN GWW + GW PA Y++ + GT
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT 1140
Query: 227 RDDSDINTSKTGEEE---KYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGK 283
+ K+ + + + YT+Q+ DE+ F KG + V+ K WW G+
Sbjct: 1141 SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ 1200
Query: 284 EGWAPASYLKKAKDDLPTRK 303
G P++Y+K D P+++
Sbjct: 1201 VGLFPSNYVKLTTDMDPSQQ 1220
Score = 57.4 bits (137), Expect = 7e-08
Identities = 65/319 (20%), Positives = 136/319 (42%), Gaps = 54/319 (16%)
Query: 177 YKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSK 236
++ ++++ L+ +V+ V+E+ + WWF ++GW P +Y++ +G S S
Sbjct: 924 WRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSG 982
Query: 237 TGEE------------------EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYI 278
+ E E+++ + Y S + ++ F++G + V +K+ + WW
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTG 1041
Query: 279 RYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLL-NKKASGDKETPPAE 337
K G P++Y+ + KD + AG +G EI+ ++ + A+G ++ A
Sbjct: 1042 TVGDKAGVFPSNYV-RLKD---SEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAP 1097
Query: 338 GEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPA--VARIAPQRAQISSPN 395
G+ I KK N + R R PA V ++P ++I+
Sbjct: 1098 GQ--LILIRKK--------NPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITP-- 1145
Query: 396 LRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSG 455
T PP + ++L + + + ++ + D ++F GQ V++K
Sbjct: 1146 --TEPP--KSTAL-----------AAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDP 1190
Query: 456 GWWYVQIGEKEGWAPASYI 474
WW ++ + G P++Y+
Sbjct: 1191 DWWKGEVNGQVGLFPSNYV 1209
Score = 47.8 bits (112), Expect = 6e-05
Identities = 106/508 (20%), Positives = 179/508 (35%), Gaps = 82/508 (16%)
Query: 420 SVEVEYY-TIAEFQSCISDGISFRGGQ----KAEVIDKNSGG---WWYVQIGEKEGWAPA 471
+V+V YY + F+S D I+ + G K E +D++ G W ++ K GW PA
Sbjct: 739 NVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPA 798
Query: 472 SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYD 531
+Y +K + +VP P P + P A +P + EP
Sbjct: 799 NYAEK------------IPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTT 846
Query: 532 IPAFG-FDSEPELSEEPVEDRASGERRPAQPHR--PSPASSLQRARFK------------ 576
+ F S S + + + AQP PS QR+ F
Sbjct: 847 PNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPV 906
Query: 577 VGESSEDVALEEETIY-------------ENEGFRPYAEDTL----SARGSSGDSDSPGS 619
+G+ + L+ + +Y +N+ + + +G G
Sbjct: 907 LGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYV 966
Query: 620 SSLS--LTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSS 677
+S + + S SGS +S + LK A A+ + S F + T ++ +
Sbjct: 967 KLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVV----SGEEFIAMYTYESSEQGDLT 1022
Query: 678 SSSSSL---SKTSGDLKPRSASD-AGIRGTPKVRAK-KDADANAGLTSCPRAKPSVRPKP 732
+ +K GD + D AG+ + VR K + AG T KP +
Sbjct: 1023 FQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ-- 1080
Query: 733 FLNRAESQSQEKMDIST----LRRQLRPTGQLRGGL--KGSKSEDSELPPQTASEAPSEG 786
+ + E++ ++ L R+ P G G L +G K + P + S G
Sbjct: 1081 VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV-KLLSPG 1139
Query: 787 SRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQE 846
+ + TP P K + Y D E++F G + VL K++
Sbjct: 1140 TSK----------ITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKED 1189
Query: 847 SGWWYVRFGELEGWAPSHYLVLDENEQP 874
WW G PS+Y+ L + P
Sbjct: 1190 PDWWKGEVNGQVGLFPSNYVKLTTDMDP 1217
Score = 45.1 bits (105), Expect = 4e-04
Identities = 59/266 (22%), Positives = 100/266 (37%), Gaps = 42/266 (15%)
Query: 238 GEEEKYVTVQ-----PYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL 292
G+ EK +Q P+ ++ + + F K + V+ + + WW+ G++GW P SY+
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYV 966
Query: 293 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL 352
K + +G E ++ K+ + P GE A +
Sbjct: 967 KLISGPIRKSTSMDSGSSESPASL--------KRVASPAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 353 PILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPR-----RESS 407
L G + V + G + + S +R + + S
Sbjct: 1019 GDL-TFQQGDVILVTKK------DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGS 1071
Query: 408 LGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQI---GE 464
LG K PE V IA + + + ++ GQ + KN GGWW ++ G+
Sbjct: 1072 LG----KKPEIAQV------IASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGK 1121
Query: 465 KE--GWAPASYIDKRKKPNLSRRTST 488
K GW PA+Y+ K P S+ T T
Sbjct: 1122 KRQIGWFPANYV-KLLSPGTSKITPT 1146
Score = 37.4 bits (85), Expect = 0.079
Identities = 13/52 (25%), Positives = 29/52 (55%)
Query: 170 QYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLE 221
Q + + +Y Q + EL+ G++++V+ K + WW + + G P+ Y++
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 37.0 bits (84), Expect = 0.10
Identities = 70/387 (18%), Positives = 126/387 (32%), Gaps = 61/387 (15%)
Query: 115 DEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVV 174
D++ R F E P + + W+ + K +T + E + + Y +
Sbjct: 703 DKLGRLFHQHQEPAKPAVQ------------APWSTAEKGPLT--ISAQENVKVVYYRAL 748
Query: 175 SNYKKQENSELSLQAGEVV-------DVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTR 227
++ + + E+++Q G++V D + E GW + GW PA Y E
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE------ 802
Query: 228 DDSDINTSKTGEEEKYVTVQPYTSQSK--------DEIGFEKGVTVEVIRKNLEGWWYIR 279
K E E V+P T + E VT W
Sbjct: 803 --------KIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADF- 853
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGE 339
W ++ K D+ + V G + + S A+G + P G+
Sbjct: 854 ---SSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPS-PVLGQ 909
Query: 340 GHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRA--------QI 391
G + + + P N D Q + Q+ I
Sbjct: 910 GEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLI 969
Query: 392 SSPNLRTRPPPRRESSLGFQLPKPPEPPSVEV----EYYTIAEFQSCISDGISFRGGQKA 447
S P ++ S L + P + V E+ + ++S ++F+ G
Sbjct: 970 SGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-V 1028
Query: 448 EVIDKNSGGWWYVQIGEKEGWAPASYI 474
++ K G WW +G+K G P++Y+
Sbjct: 1029 ILVTKKDGDWWTGTVGDKAGVFPSNYV 1055
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 11/106 (10%)
Query: 776 PQTASEAPSEGSRRSSSDL--ITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISF 833
P S + GS S + L + PA P ++ ++ Y+ + +++F
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEE--------FIAMYTYESSEQGDLTF 1023
Query: 834 PAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGK 879
G +V ++ K++ WW G+ G PS+Y+ L ++E +GK
Sbjct: 1024 QQG-DVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGK 1068
Score = 31.2 bits (69), Expect = 5.7
Identities = 12/32 (37%), Positives = 20/32 (62%), Gaps = 1/32 (3%)
Query: 1072 VLERNPNGWWYCQI-LDGVKPFKGWVPSNYLE 1102
+ ++NP GWW ++ G K GW P+NY++
Sbjct: 1103 IRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 62.8 bits (151), Expect = 2e-09
Identities = 31/117 (26%), Positives = 62/117 (52%), Gaps = 10/117 (8%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQT-IYRRYSKFFDLQMQLLDKFPIEGGQ 64
+++ +V K+ NP KHY+Y++ + + ++R + +F +L +L FP+
Sbjct: 1424 IKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWK-- 1481
Query: 65 KDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFF 121
+P P +++ R+HI+DVA KR ++ Y ++L+ +++CD V FF
Sbjct: 1482 -------LPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFF 1531
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/136 (30%), Positives = 62/136 (45%), Gaps = 15/136 (11%)
Query: 177 YKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYL--EAQNGTRDDSDINT 234
Y + ELSL G V V+EK GWW S + + GW P+ Y+ E + +
Sbjct: 122 YVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS 181
Query: 235 SKTGEE----------EKYVTVQPYTSQSKDEIGFEKGVTVEVIRK--NLEGWWYIRYL- 281
+ G T+ P++S +++E+ FEKG T+EVI K N WW +
Sbjct: 182 LRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNAR 241
Query: 282 GKEGWAPASYLKKAKD 297
G+ G P +Y+ D
Sbjct: 242 GQVGLVPKNYVVVLSD 257
Score = 57.0 bits (136), Expect = 1e-07
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 39/169 (23%)
Query: 169 EQYVVVS--NYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGT 226
E+ +V++ +Y Q++ EL ++ E + +++ +++ W + + G+VP+ Y+E +N
Sbjct: 3 EEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSL 62
Query: 227 RDDSDINTSK-------------------------------TGEEEKYVTVQP------Y 249
+ S + K +G + Y P Y
Sbjct: 63 KKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAY 122
Query: 250 TSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD 298
++ +DE+ KG V V+ K +GWW Y G+ GW P++Y+ + D+
Sbjct: 123 VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDE 171
Score = 45.1 bits (105), Expect = 4e-04
Identities = 34/131 (25%), Positives = 54/131 (41%), Gaps = 20/131 (15%)
Query: 749 TLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKK 808
+L + L+ T L + + + D+ P T +E P+ GS + +PA
Sbjct: 66 SLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK------ 119
Query: 809 EWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLV- 867
AY ++ E+S G V V+EK GWW + GW PS+Y++
Sbjct: 120 ------------FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLE 167
Query: 868 -LDENEQPDPS 877
+DE PS
Sbjct: 168 EVDEAAAESPS 178
Score = 33.9 bits (76), Expect = 0.87
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 437 DGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYI 474
D +S G + V++K S GWW + GW P++Y+
Sbjct: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165
Score = 33.5 bits (75), Expect = 1.1
Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 5/45 (11%)
Query: 1059 EETAGFQEGVSMEVLERNPNG--WWYCQILDGVKPFKGWVPSNYL 1101
EE F++G +MEV+E+ N WW C+ G G VP NY+
Sbjct: 211 EEELNFEKGETMEVIEKPENDPEWWKCKNARGQ---VGLVPKNYV 252
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/136 (30%), Positives = 62/136 (45%), Gaps = 15/136 (11%)
Query: 177 YKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYL--EAQNGTRDDSDINT 234
Y + ELSL G V V+EK GWW S + + GW P+ Y+ E + +
Sbjct: 122 YVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS 181
Query: 235 SKTGEE----------EKYVTVQPYTSQSKDEIGFEKGVTVEVIRK--NLEGWWYIRYL- 281
+ G T+ P++S +++E+ FEKG T+EVI K N WW +
Sbjct: 182 LRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNAR 241
Query: 282 GKEGWAPASYLKKAKD 297
G+ G P +Y+ D
Sbjct: 242 GQVGLVPKNYVVVLSD 257
Score = 57.0 bits (136), Expect = 1e-07
Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 39/169 (23%)
Query: 169 EQYVVVS--NYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGT 226
E+ +V++ +Y Q++ EL ++ E + +++ +++ W + + G+VP+ Y+E +N
Sbjct: 3 EEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSL 62
Query: 227 RDDSDINTSK-------------------------------TGEEEKYVTVQP------Y 249
+ S + K +G + Y P Y
Sbjct: 63 KKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAY 122
Query: 250 TSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD 298
++ +DE+ KG V V+ K +GWW Y G+ GW P++Y+ + D+
Sbjct: 123 VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDE 171
Score = 45.1 bits (105), Expect = 4e-04
Identities = 34/131 (25%), Positives = 54/131 (41%), Gaps = 20/131 (15%)
Query: 749 TLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKK 808
+L + L+ T L + + + D+ P T +E P+ GS + +PA
Sbjct: 66 SLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVK------ 119
Query: 809 EWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLV- 867
AY ++ E+S G V V+EK GWW + GW PS+Y++
Sbjct: 120 ------------FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLE 167
Query: 868 -LDENEQPDPS 877
+DE PS
Sbjct: 168 EVDEAAAESPS 178
Score = 33.9 bits (76), Expect = 0.87
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 437 DGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYI 474
D +S G + V++K S GWW + GW P++Y+
Sbjct: 128 DELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165
Score = 33.5 bits (75), Expect = 1.1
Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 5/45 (11%)
Query: 1059 EETAGFQEGVSMEVLERNPNG--WWYCQILDGVKPFKGWVPSNYL 1101
EE F++G +MEV+E+ N WW C+ G G VP NY+
Sbjct: 211 EEELNFEKGETMEVIEKPENDPEWWKCKNARGQ---VGLVPKNYV 252
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 57.8 bits (138), Expect = 6e-08
Identities = 93/383 (24%), Positives = 138/383 (36%), Gaps = 62/383 (16%)
Query: 398 TRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVI-----DK 452
TRP P++ + K P P E E + + G++ +KA+ D
Sbjct: 2433 TRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHE-----GVTSPKSKKAKEALLLREDP 2487
Query: 453 NSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTG 512
+GGW ++P S L+ PP A S+PK T
Sbjct: 2488 GAGGW--------------------QEPK-----SLLSLGSYPPAAGSSEPKAPWPKATD 2522
Query: 513 ASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQR 572
+Q+ L +E+ G P D+A E+ A+ S +SS
Sbjct: 2523 GDLAQEPGPGLTFEDS-------GNPKSP--------DKAQAEQDGAEESESSSSSSSGS 2567
Query: 573 ARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKS 632
+ SS E E + G + +S + SP SSS S + +S S
Sbjct: 2568 SSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSS 2627
Query: 633 GSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKP 692
S SSS ++ + + SS+S SSS + +++ SSSSSSSSS S T D
Sbjct: 2628 SSSSSSS--------SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSC 2679
Query: 693 RSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRR 752
S +A T A+ A +A+PS P Q Q T +
Sbjct: 2680 SSDDEAAPAPTAGPSAQAALPTKA-TKQAGKARPSAH-SPGKKTPAPQPQAPPPQPT--Q 2735
Query: 753 QLRPTGQLRGGLKGSKSEDSELP 775
L+P Q + K E LP
Sbjct: 2736 PLQPKAQAGAKSRPKKREGVHLP 2758
Score = 45.8 bits (107), Expect = 2e-04
Identities = 82/356 (23%), Positives = 128/356 (35%), Gaps = 58/356 (16%)
Query: 469 APASYIDKRKKPNLSRRTSTLTRPKVPPPAPPS-----KPKEAEEGPTGASESQDSPRKL 523
+P +DKR K +R P P PAPP+ P+ E P A+ +P
Sbjct: 2375 SPPEPVDKRAKAPKARPA-----PPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAP--- 2426
Query: 524 KYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSED 583
+ P +P + RA+ E P RP + L G +S
Sbjct: 2427 -------------LITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPK 2473
Query: 584 VALEEETIY--ENEGFRPYAED-TLSARGS----SGDSDS----PGSSSLSLTRKNSP-- 630
+E + E+ G + E +L + GS +G S+ P ++ L ++ P
Sbjct: 2474 SKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGL 2533
Query: 631 ---KSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTS 687
SG+PKS K +AE++ E + SS+S SSS + SSSSS S + +
Sbjct: 2534 TFEDSGNPKSPD--KAQAEQDGAEESESSSSSSSGSSS-----SSSSSSSSGSETEGEEE 2586
Query: 688 GDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDI 747
GD G R ++ + A++ +S + S + S S
Sbjct: 2587 GDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSS---------SSSSSSSSSSS 2637
Query: 748 STLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPP 803
S+ + S S S ++S E S SS D T P
Sbjct: 2638 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGP 2693
Score = 30.4 bits (67), Expect = 9.7
Identities = 87/413 (21%), Positives = 150/413 (36%), Gaps = 81/413 (19%)
Query: 475 DKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPA 534
D+R++P+ S RP+ AP + + G +G S + S + L + +Y++ A
Sbjct: 1512 DRREEPHRSLARRGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSD-DYELGA 1570
Query: 535 FGFDSEPELSEEPVE-----DRASGERRPAQPHRPSP--ASSLQRARFKVGESSEDVALE 587
G + SEE + +A G + H S S L+ + K+ E +A +
Sbjct: 1571 -GIRKRHKGSEEEHDALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASK 1629
Query: 588 EE---TIYENEGFRPYAEDTLSARGSSGDSDSPG-----------------SSSLSLTRK 627
+ ++ + + + + + SA G S S G + L L+ K
Sbjct: 1630 LDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLK 1689
Query: 628 NSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSS-ASFSSSITINTTCCSSS--------SS 678
+S + +++ K++ A+ + HS AS SS + NT +
Sbjct: 1690 SSREGKHKRAAKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQ 1749
Query: 679 SSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAE 738
SS T L A ++ G PK+ + GL + PR +++PKP +R
Sbjct: 1750 GPSSSKLTPSLLCSMVAKNSKAAGGPKLTKR-------GL-AAPR---TLKPKPATSR-- 1796
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGL-------KGSKSEDSELPPQTASEAPSEGSRRSS 791
K L R+ + S+ ED E + EA G R +
Sbjct: 1797 -----KQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLGA 1851
Query: 792 SD--------------LITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSE 830
+ L A+ P PT GP+ S + A QK + E
Sbjct: 1852 RERALSPGLEESGLGLLARFAASALPSPT----VGPSLSVVQLEAKQKARKKE 1900
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 56.2 bits (134), Expect = 2e-07
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 10/123 (8%)
Query: 6 VQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQT-IYRRYSKFFDLQMQLLDKFPIEGGQ 64
+ D + EK +P+K Y+Y++ V ++ T I R + +F +L +L FP
Sbjct: 1367 ISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSH-- 1424
Query: 65 KDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEAR 124
+P P + + RS VA +R + ++ Y L+ PP +++CD V+ FF
Sbjct: 1425 -------LPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPL 1477
Query: 125 PED 127
P D
Sbjct: 1478 PRD 1480
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 56.2 bits (134), Expect = 2e-07
Identities = 165/749 (22%), Positives = 274/749 (36%), Gaps = 122/749 (16%)
Query: 122 EARPEDVNPPKEDYGSSK-RKSVWLSSWA--ESPKKDVTGADATAEPMILEQYVVVSNYK 178
E++ + PP+ED +S R+ S + + P+ + D P S
Sbjct: 1163 ESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPET 1222
Query: 179 KQENSEL--SLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSK 236
K++NS L S Q E+++V+EK SEE ++L ++ S+ +S
Sbjct: 1223 KEQNSALPTSSQDEELMEVVEK----------SEEPAGQILSHLSSELKEMSTSNFESSP 1272
Query: 237 TGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAK 296
EE V++ SQS+ + VEV ++ W G ++P K
Sbjct: 1273 EVEERPAVSLTLDQSQSQASLE-----AVEV--PSMASSW-----GGPHFSPEH---KEL 1317
Query: 297 DDLPTRKKNLAGPVEI-----------IGNIMEISNLLNKKASGDKETPPA--------E 337
+ P R+ + P+E G E+ LN ET P+
Sbjct: 1318 SNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTR 1377
Query: 338 GEGHEAP------------IAKKEISLPILC---------NASNGSAVGVPD---RTVSR 373
GH + + + IS P+L +S+ S+ + D RT SR
Sbjct: 1378 SSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSR 1437
Query: 374 LAQG--SPAV--ARIAPQRAQIS--SPNLRTRP-PPRRESSLGFQLPKP---PEPPSVEV 423
++ SP + P R +S SP ++ P P R S P+P P+ P
Sbjct: 1438 RSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRS 1497
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLS 483
+ E + R G ++ V K +G++ + +D + +
Sbjct: 1498 RSPSSPELNNKCLTPQRERSGSESSVDQKTVAR---TPLGQRSRSGSSQELDVKPSASPQ 1554
Query: 484 RRTSTLTRP--KVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEP 541
R+ + + P K P + + P S+S+ SPR+ + S P
Sbjct: 1555 ERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRS------------GSSP 1602
Query: 542 ELSEEP-VEDRA-SGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRP 599
E+ ++P RA SG +P P+P + +R+R G SS+ E E
Sbjct: 1603 EVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR--SGSSSKGRGPSPEGSSSTESSPE 1660
Query: 600 YAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSS 659
+ + +AR S S P + S + P+ S +SS L KA + ++ ++ SS
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKS-----RTPPRRRSSRSSPELTRKARLSRRS---RSASS 1712
Query: 660 ASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLT 719
+ + S T S S SS K+ + RSAS + T + R + + GL
Sbjct: 1713 SPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR-RGRSPSPKPRGLQ 1771
Query: 720 SCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTA 779
S R K R +S S R++ R ++ +G S P +
Sbjct: 1772 R--SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQE 1829
Query: 780 SEAPSEGSRRSSSDLITLPATTPPCPTKK 808
S S RR S TPP K+
Sbjct: 1830 SSRTSSRRRRGRS-------RTPPTSRKR 1851
Score = 54.3 bits (129), Expect = 6e-07
Identities = 96/399 (24%), Positives = 143/399 (35%), Gaps = 98/399 (24%)
Query: 469 APASYIDKRKKPNLSRRTSTLTRPKVP------------PP--------APPSKPKEA-- 506
APAS R P LS + LT P+VP PP PPS P ++
Sbjct: 2362 APASLTSARMAPALSG--ANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRM 2419
Query: 507 --EEGPTGASESQDSPRKL----KYEEPEYDIPAFGFDSE-------------PELSEEP 547
E P+ +S +P + ++P +P+ D LS
Sbjct: 2420 TSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGA 2479
Query: 548 VEDRAS--GERR-------PAQPH-------------RPSPASSLQRARFKVGESSEDVA 585
V S G+ P PH +PS ++LQ A+ + SS +
Sbjct: 2480 VATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSS 2539
Query: 586 LEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSS-----SLSLTRKNSP--------KS 632
+ + + S+ S SDS GSS ++L R SP +
Sbjct: 2540 SSSSSSSSSSS-------SSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVRE 2592
Query: 633 GSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKP 692
G P + K K ++ + + SS+S SSS ++ SSSSSSSSS S +S
Sbjct: 2593 GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSS----SSSSSSSSSSSSSSSSSSSSSSS 2648
Query: 693 RSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRR 752
S + G + PK + K + PR KP + +S+S + RR
Sbjct: 2649 PSPAKPGPQALPKPASPKKPPPGERRSRSPR-------KPIDSLRDSRSLSYSPVE--RR 2699
Query: 753 QLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSS 791
+ P R S S + S +PS RR +
Sbjct: 2700 RPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRET 2738
Score = 45.4 bits (106), Expect = 3e-04
Identities = 74/347 (21%), Positives = 127/347 (36%), Gaps = 41/347 (11%)
Query: 464 EKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKL 523
++ GW+ + +R + +RR + +R PA + + G S S+ R+
Sbjct: 538 QRPGWSRSRNTQRRGRSRSARRGRSHSRS----PATRGRSRSRTPARRGRSRSRTPARRR 593
Query: 524 KYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQ--PHRPSPASSLQRARFKVGES- 580
S P S R PA+ SP R+R S
Sbjct: 594 SRSRTP--------TRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSG 645
Query: 581 ---SEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKS 637
S A + R + AR SG S S + +R +P+ G +S
Sbjct: 646 RSRSRTPARRGRSRSRTPARRGRSRSRTPAR-RSGRSRSRTPARRGRSRSRTPRRGRSRS 704
Query: 638 SSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTS-GDLKPRSAS 696
SL++ + +++ + S +S T+ S S+SS + K+ + RS S
Sbjct: 705 RSLVR-RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLS 763
Query: 697 DAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRP 756
+ ++ ++ +G + CP+ K P+ R+ S S + P
Sbjct: 764 SPRSKAKSRLSLRRSL---SGSSPCPKQKSQTPPR----RSRSGSSQ------------P 804
Query: 757 TGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPP 803
+ R + S+S S PP+ S+ PS S SSS + + TPP
Sbjct: 805 KAKSRTPPRRSRSSSSP-PPKQKSKTPSRQSHSSSSPHPKVKSGTPP 850
Score = 41.6 bits (96), Expect = 0.004
Identities = 109/568 (19%), Positives = 197/568 (34%), Gaps = 73/568 (12%)
Query: 490 TRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPV- 548
TR + PP +P P+ + + S + PE PA S E+S P
Sbjct: 400 TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTS 459
Query: 549 EDRASGERRPAQPHRPSPASSLQRAR----FKVGESSEDVALEEETIYENEGFRPYAEDT 604
++R+ G + + H +P+ + R+R K G S + + P +
Sbjct: 460 KNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRG---HSRSRSPQWRRS 516
Query: 605 LSA-----------RGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEM 653
SA RG S PG S +N+ + G +S S + ++ + A
Sbjct: 517 RSAQRWGRSRSPQRRGRSRSPQRPGWS----RSRNTQRRG--RSRSARRGRSHSRSPATR 570
Query: 654 GKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDAD 713
G++ S + + T S S + + S P + R + R++ +
Sbjct: 571 GRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSP 630
Query: 714 ANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSE 773
S A+ S R + +S+ + R + R + G S+S
Sbjct: 631 VRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG---RSRSRTPA 687
Query: 774 LPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISF 833
++ S P G RS S L+ + P ++ G ++ S + + S
Sbjct: 688 RRGRSRSRTPRRGRSRSRS-LVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSS 746
Query: 834 PAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEG 893
P + ++ ++ A S + P K+ P + R G
Sbjct: 747 PEMKKSRISSRRSRS-----LSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR-RSRSG 800
Query: 894 KSDSLEKIERRVQALNTVNQSKKATPPIP---SKPPGGFGKTSGTPAVKMRNGVRQVAVR 950
S + + ++ +S+ ++ P P SK P +S +P K+++G
Sbjct: 801 SS------QPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGT------ 848
Query: 951 PQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAAS 1010
PP+ +++ +S+T +R S F + S E K R R +
Sbjct: 849 --------PPRQGSITSPQANEQSVTP-------QRRSCFES--SPDPELKSRTPSRHSC 891
Query: 1011 QGSDSPLL-----PAQRNSIPVSPVRPK 1033
GS P + P Q S SP +PK
Sbjct: 892 SGSSPPRVKSSTPPRQSPSRSSSP-QPK 918
Score = 40.8 bits (94), Expect = 0.007
Identities = 106/508 (20%), Positives = 176/508 (34%), Gaps = 99/508 (19%)
Query: 476 KRKKPNLSRRT-STLTRPKVPPPAPPSK--------PKEAEEGPTGASESQDSPR-KLKY 525
K+K RR+ S ++PK PP + PK+ + P+ S S SP K+K
Sbjct: 787 KQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKS 846
Query: 526 EEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPA-SSLQRARFKVGESSEDV 584
P P G + P+ +E+ V + +RR P P S +R SS
Sbjct: 847 GTP----PRQGSITSPQANEQSV----TPQRRSCFESSPDPELKSRTPSRHSCSGSSP-- 896
Query: 585 ALEEETIYENEGFRPYAEDTLSARGSSGDSDSPG---SSSLSLTRKNSPKSGSPKSSSLL 641
P + + R S S SP + +S +++ S SP S +
Sbjct: 897 --------------PRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVT 942
Query: 642 KLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIR 701
+ ++ S S S++ S S SSS +K + PR + I
Sbjct: 943 SRTTPRRSR--------SVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSIS 994
Query: 702 GTPKVRAK-------------------KDA---DANAGLTSCPRAKPSVRP-KPFLNRAE 738
PKV+A+ KD+ L+ C K S P + + +
Sbjct: 995 PYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSS 1054
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798
Q + + S R + ++R S S S+ + +P G RSSS + L
Sbjct: 1055 LQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSK-----SQTSPKGGRSRSSSPVTELA 1109
Query: 799 ATTP-----------------PCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQV 841
+ +P P + ++ ++SY T + + S + E
Sbjct: 1110 SRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMA 1169
Query: 842 LEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKI 901
L QE + ++P+ S DT+ R+ G S E
Sbjct: 1170 LPPQEDA------TASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETK 1223
Query: 902 ERRVQALNTVNQSKKATPPI-PSKPPGG 928
E+ AL T +Q ++ + S+ P G
Sbjct: 1224 EQN-SALPTSSQDEELMEVVEKSEEPAG 1250
Score = 40.8 bits (94), Expect = 0.007
Identities = 97/494 (19%), Positives = 161/494 (32%), Gaps = 104/494 (21%)
Query: 302 RKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNG 361
R + PV I G+ + L + + P G +P + L S
Sbjct: 2342 RSAHATAPVNIAGS-RTAAALAPASLTSARMAPALSGANLTSP----RVPLSAYERVSGR 2396
Query: 362 SAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRP-----PPRRESSLGFQLPKPP 416
++ + DR SR +P+ +R+ +RA S + P PP ++ P+ P
Sbjct: 2397 TSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQ------PRSP 2450
Query: 417 EPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK 476
P + + + + ++ S G A G+ G
Sbjct: 2451 VPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTS---------SAGDHNGML------- 2494
Query: 477 RKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFG 536
VP P P ++ G AS P L
Sbjct: 2495 ----------------SVPAPGVP----HSDVGEPPASTGAQQPSAL------------- 2521
Query: 537 FDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEG 596
+ +P ++R S + S +SS + G SS D +
Sbjct: 2522 ------AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVA 2575
Query: 597 FRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKN 656
+ T + + + + P + R++S S S SSS + +
Sbjct: 2576 LKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSS-----------SSSSSS 2624
Query: 657 HSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSAS----DAGIRGTPKVRAKKDA 712
SS+S SSS + +++ SSSSSSS S +K P+ AS G R + R D+
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDS 2684
Query: 713 ---DANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKS 769
+ + R +PS +P P +S S E+ G RG S+S
Sbjct: 2685 LRDSRSLSYSPVERRRPSPQPSP--RDQQSSSSER-------------GSRRGQRGDSRS 2729
Query: 770 EDSELPPQTASEAP 783
+ +T S P
Sbjct: 2730 PSHKRRRETPSPRP 2743
Score = 39.7 bits (91), Expect = 0.016
Identities = 124/565 (21%), Positives = 183/565 (32%), Gaps = 97/565 (17%)
Query: 488 TLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKL---KYEEPEYDIPAF--------- 535
TL P S P+ E+ + SQD K EEP I +
Sbjct: 1205 TLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMS 1264
Query: 536 --GFDSEPELSEEPVE----DRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEE 589
F+S PE+ E P D++ + PS ASS F S E L
Sbjct: 1265 TSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHF----SPEHKELSNS 1320
Query: 590 TIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNA 649
+ EN P G G + G SS N P ++ L +K
Sbjct: 1321 PLRENSFGSPLE---FRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKE---- 1373
Query: 650 QAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAK 709
Q+ HSS+ S S+ S SS L D PR+ S + +
Sbjct: 1374 QSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVL-----DAVPRTPS------RERSSSA 1422
Query: 710 KDADANAGLTSCPRAKPSVRPKPFLNRAE-SQSQEKMDISTLRRQLRPTGQLRGGLKGSK 768
+ GL P + P L + S+ + S+ + P RG +
Sbjct: 1423 SSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDS 1482
Query: 769 SEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQD 828
S + + PQT P SR SS + TP ++E G +S Q
Sbjct: 1483 SPEPKALPQT----PRPRSRSPSSPELNNKCLTP----QRERSGSESSVD--------QK 1526
Query: 829 SEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKG 888
+ P G ++ SG S +ELD P+
Sbjct: 1527 TVARTPLG------QRSRSG----------------------------SSQELDVKPSAS 1552
Query: 889 RQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVA 948
Q +SDS + + + ++P + SK ++ + ++++ R
Sbjct: 1553 PQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAP 1612
Query: 949 VRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERA 1008
SP PK RR+ S +++ G RG S ST S K R A R
Sbjct: 1613 RAQSGSDSSPEPKAPAPRALPRRSRSGSSSKG-RGPSPEGSSSTESSPEHPPKSRTARR- 1670
Query: 1009 ASQGSDSP----LLPAQRNSIPVSP 1029
S+ S P P +R S SP
Sbjct: 1671 GSRSSPEPKTKSRTPPRRRSSRSSP 1695
Score = 35.4 bits (80), Expect = 0.30
Identities = 83/365 (22%), Positives = 130/365 (35%), Gaps = 57/365 (15%)
Query: 684 SKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQ--- 740
S+T+ L P S + A R P + L++ R P P L+RA S+
Sbjct: 2355 SRTAAALAPASLTSA--RMAPALSGANLTSPRVPLSAYERVSGRTSP-PLLDRARSRTPP 2411
Query: 741 ---SQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPP---QTASEAPSEGSRRSSSDL 794
SQ +M T R P+ ++ G S LPP Q S PS S +S
Sbjct: 2412 SAPSQSRM---TSERAPSPSSRM-----GQAPSQSLLPPAQDQPRSPVPSAFSDQSRC-- 2461
Query: 795 ITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPA-GVEVQVLEKQESGWWYVR 853
L A T P + A + T SA + +S PA GV + + + +
Sbjct: 2462 --LIAQTTPVAGSQSLSSGAVATTTSSAGD--HNGMLSVPAPGVPHSDVGEPPASTGAQQ 2517
Query: 854 FGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQ 913
L P+ + S + + + G S S + + Q
Sbjct: 2518 PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDS------EGSSLPVQ 2571
Query: 914 SKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNE 973
+ A +PS P P +R G RP P P RR+
Sbjct: 2572 PEVALKRVPSPTPA--------PKEAVREG------RPPE----PTPAKRK-----RRSS 2608
Query: 974 SLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPA-QRNSIPVSPVRP 1032
S +++ +SS S++ S+++ + + ++S S SP P Q P SP +P
Sbjct: 2609 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKP 2668
Query: 1033 KPIEK 1037
P E+
Sbjct: 2669 PPGER 2673
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 52.8 bits (125), Expect = 2e-06
Identities = 84/370 (22%), Positives = 138/370 (37%), Gaps = 63/370 (17%)
Query: 484 RRTSTLTR-----PKVPPPAPPSKPK--------------------EAEEGPTGASESQD 518
+RT T+ R P+ P PAP S PK + + +GA+ S
Sbjct: 702 KRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSS 761
Query: 519 SPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQ--------PHRPSPASSL 570
S R+ D G D + + + DR+S + RP + P +P +S
Sbjct: 762 SSREKGSRRKALD----GGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGS 817
Query: 571 QRARFKVGESSEDVALEEET---IYENEGFRPYAEDTLSA-RGSSG-----DSDS----- 616
+ SS V L+ + I E A+D SA GS G D +S
Sbjct: 818 GSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFL 877
Query: 617 -PGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSS 675
P + + K +P S PK + K+KA+ A+ G + + + + S
Sbjct: 878 KPDERAPTEMAKAAPGSTKPKKT---KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSG 934
Query: 676 SSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFL- 734
S SL K+ D ++A G T + ++ A T P+A P P P L
Sbjct: 935 GSGGQVSLKKSKADSCSQAAGTKGAEETS--WSGEERAAKVPSTPPPKAAP---PPPALT 989
Query: 735 --NRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSS 792
++ S + ++S L + +RGG + + E+ E + E + ++S
Sbjct: 990 PDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATS 1049
Query: 793 DLITLPATTP 802
P+T P
Sbjct: 1050 TAAAAPSTAP 1059
Score = 33.1 bits (74), Expect = 1.5
Identities = 83/395 (21%), Positives = 137/395 (34%), Gaps = 106/395 (26%)
Query: 495 PPPAPPSKPKEAEEGPTGASESQD----SPRKLKYEEPEYDIPAFGFDSEPELSEE---- 546
PPPAP K E PTG++ S SP + + EE E + + E LS+
Sbjct: 240 PPPAPEQKYDPFE--PTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRI 297
Query: 547 -----------PVEDRASGERRP---AQPHRPSPA-------------SSLQRARFKVGE 579
+ G+ P AQP +P+PA +++R F VG
Sbjct: 298 SETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGT 357
Query: 580 SSE-----DVALEEET-----------------IYENEGFRPYAEDTLSAR----GSSGD 613
+E V++E T I E E +P E L+ G
Sbjct: 358 EAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAA 417
Query: 614 SDSPGSSSLSLTRK--NSPKSGSPKSSSLLKLKAEKNA----QAEMGK------------ 655
+P +S+ + P +P+ L L AE + Q ++G+
Sbjct: 418 RPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRW 477
Query: 656 -----------------NHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDA 698
S S + + + S K SG+ K ++S +
Sbjct: 478 GGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSS 537
Query: 699 GIRGTPKVRAKK-DADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPT 757
G + P A D+ + P + S + R+ S+S+ + + RR+ R T
Sbjct: 538 GTQPAPPAPASPWDSKKHRSRDRKPGSHASSSAR---RRSRSRSRSR----STRRRSRST 590
Query: 758 GQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSS 792
+ RGG + S+S + + ++ P S SSS
Sbjct: 591 DRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSS 625
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 52.4 bits (124), Expect = 2e-06
Identities = 113/556 (20%), Positives = 197/556 (35%), Gaps = 54/556 (9%)
Query: 499 PPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRP 558
P K K E P+ SE+ + R P PA + +PE +E E G + P
Sbjct: 891 PSFKVKRKE--PSEISEASEEKR------PRPSTPAEEDEDDPEQEKEAGEPGRPGTKPP 942
Query: 559 AQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPG 618
+ R F + E+ + E + + E ED D +
Sbjct: 943 KRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDE--------DREEAV 994
Query: 619 SSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSS 678
++ T + + SSS L A+ + + + + S+S SSS + +++ SSSSS
Sbjct: 995 DTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSS 1054
Query: 679 SSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPS-VRPKPFLNRA 737
SSSS S + + + + P A + R S V P P +
Sbjct: 1055 SSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEAS 1114
Query: 738 ESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRR-----SSS 792
++ + S LRP + G E P P RR S+
Sbjct: 1115 PARPAGPTEESPPSAPLRPP-EPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAI 1173
Query: 793 DLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYV 852
+++ P P P + ++ GPA+ + +++ + + V+ E G
Sbjct: 1174 EVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRA 1233
Query: 853 ----RFGELEGWAPSHY--LVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQ 906
R E E P L + + P+ + L +PA ++ +++ ++ ER
Sbjct: 1234 GGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAV--EDSEATETSDEAERPRP 1291
Query: 907 ALNTV------NQSKKATPPIPS-KPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFV-SP 958
L+ + + K TPP P+ +PP + PA + +V P+ V +
Sbjct: 1292 LLSHILLEHNYALAVKPTPPAPALRPP----EPVPAPAALFSSPADEVLEAPEVVVAEAE 1347
Query: 959 PPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLL 1018
PK L E +G S+ S++++ +G L R+
Sbjct: 1348 EPKPQQLQQQREEGEEEGEEEG----EEEEEESSDSSSSSDGEGALRRRSLRS------- 1396
Query: 1019 PAQRNSIPVSPVRPKP 1034
A+R P P P P
Sbjct: 1397 HARRRRPPPPPPPPPP 1412
Score = 41.6 bits (96), Expect = 0.004
Identities = 60/251 (23%), Positives = 91/251 (36%), Gaps = 40/251 (15%)
Query: 568 SSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTR- 626
SS A + G ++ ++ F +DT S+ G S G+ S
Sbjct: 220 SSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGST 279
Query: 627 ---KNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSAS-----FSSSITINTTCCSSSSS 678
++S S S S+S ++E + Q + H SAS S++I T +SSS+
Sbjct: 280 PYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSA 339
Query: 679 SSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAE 738
SSSSLS +S S+S + +DAN A
Sbjct: 340 SSSSLSSSSSSSSSSSSSQF-----------RSSDAN-------------------YPAY 369
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798
+S + T R T + G +++ PP S P E SR + D P
Sbjct: 370 YESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQD-YRPP 428
Query: 799 ATTPPCPTKKE 809
A+ P P E
Sbjct: 429 ASEAPPPEPPE 439
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 52.4 bits (124), Expect = 2e-06
Identities = 21/53 (39%), Positives = 35/53 (66%)
Query: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLE 221
++Y + +Y Q EL L AG++++VI + E GWW V + ++G+VP +YLE
Sbjct: 362 QEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLE 414
Score = 49.7 bits (117), Expect = 2e-05
Identities = 21/64 (32%), Positives = 36/64 (56%)
Query: 231 DINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPAS 290
+I + ++Y + YT+Q+ DE+ G +EVI + +GWW + G+ G+ P S
Sbjct: 352 EIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGS 411
Query: 291 YLKK 294
YL+K
Sbjct: 412 YLEK 415
Score = 43.9 bits (102), Expect = 8e-04
Identities = 39/162 (24%), Positives = 71/162 (43%), Gaps = 13/162 (8%)
Query: 318 EISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQG 377
+I + + K++G + P + + +E++ P+ + + G+ R S L G
Sbjct: 264 DIDSFIQAKSTGTEPPAPVPYQNYY----DREVT-PLTSSPGIQPSCGMIKR-FSGLLHG 317
Query: 378 SPAVARIAPQRAQISSPNLRTRPPPRRE---SSLGFQLPKPPEPPSVEVEYYTIAEFQSC 434
SP +A A +S T P R E +++ Q + P S EY + ++ +
Sbjct: 318 SPKTTSLA---ASAASTETLTPTPERNEGVYTAIAVQEIQG-NPASPAQEYRALYDYTAQ 373
Query: 435 ISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK 476
D + G EVI + GWW V+ + G+ P SY++K
Sbjct: 374 NPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEK 415
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 16/97 (16%)
Query: 786 GSRRSSSDLITLPATTPPCPTKKEWEG----------------PATSYMTCSAYQKVQDS 829
GS +++S + +T PT + EG PA Y Y
Sbjct: 317 GSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPD 376
Query: 830 EISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL 866
E+ AG ++V+ + E GWW V G+ P YL
Sbjct: 377 ELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYL 413
Score = 30.4 bits (67), Expect = 9.7
Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 19/103 (18%)
Query: 1008 AASQGSDSPLLPA-QRN-----SIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDE-E 1060
AAS S L P +RN +I V ++ P +Q Y ++ DY +
Sbjct: 325 AASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQ--------EYRALYDYTAQNPD 376
Query: 1061 TAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEK 1103
G +EV+ +GWW + +G+VP +YLEK
Sbjct: 377 ELDLSAGDILEVILEGEDGWWTVER----NGQRGFVPGSYLEK 415
>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
Length = 614
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227
E+Y+ V ++ Q+ +L+ + GE++ VIEK GWW ++ +G VP TYLE +
Sbjct: 93 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 150
Query: 228 DDSDINTSKTGEEE 241
++ +S+ G EE
Sbjct: 151 EEEGQESSEEGSEE 164
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279
E + +++++ + TGEE Y+ V +T+Q ++ F+KG + VI K +GWW +
Sbjct: 75 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 132
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321
G EG P +YL+ ++ ++ + G E + + E ++
Sbjct: 133 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 174
Score = 38.1 bits (87), Expect = 0.046
Identities = 39/186 (20%), Positives = 76/186 (40%), Gaps = 24/186 (12%)
Query: 737 AESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLIT 796
+ESQ +E ++ + + + G + S+SEDSE +A E + ++
Sbjct: 29 SESQLKEALEPNKRQHIYQRVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE--- 85
Query: 797 LPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE 856
+W Y+ + Q +++F G + V+EK+ GWW + +
Sbjct: 86 ----------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAK 134
Query: 857 -LEGWAPSHYL----VLDENEQPDPSGKELDT----VPAKGRQNEGKSD-SLEKIERRVQ 906
EG P YL +E ++ G E D A G + + ++D +++ +
Sbjct: 135 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAIS 194
Query: 907 ALNTVN 912
+NTV+
Sbjct: 195 EINTVD 200
Score = 36.2 bits (82), Expect = 0.18
Identities = 18/55 (32%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 1049 YVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLE 1102
Y+++ D+ + F++G + V+E+ P+GWW I K +G VP YLE
Sbjct: 95 YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKDAKGNEGLVPRTYLE 146
Score = 33.9 bits (76), Expect = 0.87
Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475
EY + +F + ++F+ G+ VI+K GWW + + EG P +Y++
Sbjct: 94 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 146
>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
Length = 677
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227
E+Y+ V ++ Q+ +L+ + GE++ VIEK GWW ++ +G VP TYLE +
Sbjct: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 212
Query: 228 DDSDINTSKTGEEE 241
++ +S+ G EE
Sbjct: 213 EEEGQESSEEGSEE 226
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279
E + +++++ + TGEE Y+ V +T+Q ++ F+KG + VI K +GWW +
Sbjct: 137 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 194
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321
G EG P +YL+ ++ ++ + G E + + E ++
Sbjct: 195 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 236
Score = 38.1 bits (87), Expect = 0.046
Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 7/134 (5%)
Query: 970 RRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSP 1029
R+ E T D L + + + +R E E S+ DS +
Sbjct: 81 RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEE 140
Query: 1030 VRPKPIEKSQFIHNNLKDVYVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDG 1088
+ E ++ + + Y+++ D+ + F++G + V+E+ P+GWW I
Sbjct: 141 EEKEENESHKW---STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKD 194
Query: 1089 VKPFKGWVPSNYLE 1102
K +G VP YLE
Sbjct: 195 AKGNEGLVPRTYLE 208
Score = 34.7 bits (78), Expect = 0.51
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798
+Q + + ++ R + G + S+SEDSE +A E + ++
Sbjct: 93 TQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE----- 147
Query: 799 ATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE-L 857
+W Y+ + Q +++F G + V+EK+ GWW + +
Sbjct: 148 --------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGN 198
Query: 858 EGWAPSHYL-VLDENEQPDPSGKE 880
EG P YL E E+ S +E
Sbjct: 199 EGLVPRTYLEPYSEEEEGQESSEE 222
Score = 33.9 bits (76), Expect = 0.87
Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475
EY + +F + ++F+ G+ VI+K GWW + + EG P +Y++
Sbjct: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208
>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
Length = 732
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227
E+Y+ V ++ Q+ +L+ + GE++ VIEK GWW ++ +G VP TYLE +
Sbjct: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 212
Query: 228 DDSDINTSKTGEEE 241
++ +S+ G EE
Sbjct: 213 EEEGQESSEEGSEE 226
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279
E + +++++ + TGEE Y+ V +T+Q ++ F+KG + VI K +GWW +
Sbjct: 137 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 194
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321
G EG P +YL+ ++ ++ + G E + + E ++
Sbjct: 195 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 236
Score = 38.1 bits (87), Expect = 0.046
Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 7/134 (5%)
Query: 970 RRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSP 1029
R+ E T D L + + + +R E E S+ DS +
Sbjct: 81 RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEE 140
Query: 1030 VRPKPIEKSQFIHNNLKDVYVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDG 1088
+ E ++ + + Y+++ D+ + F++G + V+E+ P+GWW I
Sbjct: 141 EEKEENESHKW---STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKD 194
Query: 1089 VKPFKGWVPSNYLE 1102
K +G VP YLE
Sbjct: 195 AKGNEGLVPRTYLE 208
Score = 34.7 bits (78), Expect = 0.51
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798
+Q + + ++ R + G + S+SEDSE +A E + ++
Sbjct: 93 TQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE----- 147
Query: 799 ATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE-L 857
+W Y+ + Q +++F G + V+EK+ GWW + +
Sbjct: 148 --------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGN 198
Query: 858 EGWAPSHYL-VLDENEQPDPSGKE 880
EG P YL E E+ S +E
Sbjct: 199 EGLVPRTYLEPYSEEEEGQESSEE 222
Score = 33.9 bits (76), Expect = 0.87
Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475
EY + +F + ++F+ G+ VI+K GWW + + EG P +Y++
Sbjct: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208
>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
Length = 733
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227
E+Y+ V ++ Q+ +L+ + GE++ VIEK GWW ++ +G VP TYLE +
Sbjct: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 212
Query: 228 DDSDINTSKTGEEE 241
++ +S+ G EE
Sbjct: 213 EEEGQESSEEGSEE 226
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279
E + +++++ + TGEE Y+ V +T+Q ++ F+KG + VI K +GWW +
Sbjct: 137 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 194
Query: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321
G EG P +YL+ ++ ++ + G E + + E ++
Sbjct: 195 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 236
Score = 38.1 bits (87), Expect = 0.046
Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 7/134 (5%)
Query: 970 RRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSP 1029
R+ E T D L + + + +R E E S+ DS +
Sbjct: 81 RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEE 140
Query: 1030 VRPKPIEKSQFIHNNLKDVYVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDG 1088
+ E ++ + + Y+++ D+ + F++G + V+E+ P+GWW I
Sbjct: 141 EEKEENESHKW---STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKD 194
Query: 1089 VKPFKGWVPSNYLE 1102
K +G VP YLE
Sbjct: 195 AKGNEGLVPRTYLE 208
Score = 34.7 bits (78), Expect = 0.51
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798
+Q + + ++ R + G + S+SEDSE +A E + ++
Sbjct: 93 TQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE----- 147
Query: 799 ATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE-L 857
+W Y+ + Q +++F G + V+EK+ GWW + +
Sbjct: 148 --------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGN 198
Query: 858 EGWAPSHYL-VLDENEQPDPSGKE 880
EG P YL E E+ S +E
Sbjct: 199 EGLVPRTYLEPYSEEEEGQESSEE 222
Score = 33.9 bits (76), Expect = 0.87
Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475
EY + +F + ++F+ G+ VI+K GWW + + EG P +Y++
Sbjct: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,996,082
Number of Sequences: 37866
Number of extensions: 2655182
Number of successful extensions: 18017
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 627
Number of HSP's that attempted gapping in prelim test: 13293
Number of HSP's gapped (non-prelim): 3789
length of query: 1105
length of database: 18,247,518
effective HSP length: 113
effective length of query: 992
effective length of database: 13,968,660
effective search space: 13856910720
effective search space used: 13856910720
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.