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Search of human proteins with 55741709
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741709 RNA binding motif protein 25 [Homo sapiens]
(843 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 1685 0.0
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 232 1e-60
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 191 2e-48
gi|148746195 trichohyalin [Homo sapiens] 185 1e-46
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 182 1e-45
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 180 4e-45
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 180 6e-45
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 164 4e-40
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 164 4e-40
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 160 4e-39
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 154 3e-37
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 149 8e-36
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 149 1e-35
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 147 5e-35
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 146 7e-35
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 145 2e-34
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 140 6e-33
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 137 5e-32
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 135 1e-31
gi|52426743 cisplatin resistance-associated overexpressed protei... 135 2e-31
gi|19923485 cisplatin resistance-associated overexpressed protei... 135 2e-31
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 133 8e-31
gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens] 130 7e-30
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 126 7e-29
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 125 1e-28
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 118 2e-26
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 117 6e-26
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 116 8e-26
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 115 1e-25
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 115 2e-25
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 1685 bits (4364), Expect = 0.0
Identities = 843/843 (100%), Positives = 843/843 (100%)
Query: 1 MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSM 60
MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSM
Sbjct: 1 MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSM 60
Query: 61 VGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQ 120
VGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQ
Sbjct: 61 VGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQ 120
Query: 121 GASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN 180
GASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN
Sbjct: 121 GASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN 180
Query: 181 GNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEK 240
GNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEK
Sbjct: 181 GNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEK 240
Query: 241 KEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK 300
KEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK
Sbjct: 241 KEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK 300
Query: 301 ERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRD 360
ERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRD
Sbjct: 301 ERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRD 360
Query: 361 RDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE 420
RDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE
Sbjct: 361 RDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE 420
Query: 421 REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE
Sbjct: 421 REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
Query: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540
REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK
Sbjct: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540
Query: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600
EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP
Sbjct: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600
Query: 601 MEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPE 660
MEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPE
Sbjct: 601 MEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPE 660
Query: 661 EHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGED 720
EHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGED
Sbjct: 661 EHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGED 720
Query: 721 DKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKII 780
DKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKII
Sbjct: 721 DKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKII 780
Query: 781 EYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIG 840
EYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIG
Sbjct: 781 EYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIG 840
Query: 841 LVK 843
LVK
Sbjct: 841 LVK 843
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 232 bits (591), Expect = 1e-60
Identities = 129/325 (39%), Positives = 203/325 (62%), Gaps = 10/325 (3%)
Query: 293 EEKGKKEKERQEIEKERRERERERERERER---REREREREREREREKEKERERERERDR 349
E +KE+ER+ EK + ERE +R+RER R R R+R+R RER+R++EKERER+ +R+R
Sbjct: 55 ERNRQKERERRR-EKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113
Query: 350 DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER 409
DR R KER+R ++RER+ +R+ ER DR D R RE+ RD E+ERER+ +RER+R+ ER
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173
Query: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
R++ERERE+ R+ RE++++R++E ED + R ER+ RE+E + K RER
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE-RERETETETERKRQTDRER 232
Query: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQ---KRLRDRE 526
+ R+ E+E E++ ER R +E +R KE + D DRD + + Q KR R E
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 527 KEMEAD-ERDRKREKEELEEIRQRLLAEGHPDPDAELQR-MEQEAERRRQPQIKQEPESE 584
++ E + +R+R+RE+E E ++ E + + E QR E++ E+ R+ + K++ E +
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352
Query: 585 EEEEEKQEKEEKREEPMEEEEEPEQ 609
E + +E +R+ E E E E+
Sbjct: 353 RERNRQTGREGRRQAERERERERER 377
Score = 220 bits (560), Expect = 5e-57
Identities = 132/367 (35%), Positives = 217/367 (59%), Gaps = 39/367 (10%)
Query: 268 EMEEDKRDLISREISKFR--DTHKKLEEEKGKKEKERQEIEKERRERERERERERER-RE 324
E E D++ RE + R D H++ + ++ +KE+ERQ + R+RE+ER R++ER RE
Sbjct: 72 ERETDRKRERRREKDRHRKRDRHRERQRDR-EKERERQTDRERDRQREKERNRQKERERE 130
Query: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
ERE ER R+R+ + +RERER+RD +++R ++ DR+R R+ +R+R +ER ++N+ R
Sbjct: 131 TEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190
Query: 385 REKSRD-------------RERERERE------------RERERERERERERERERERER 419
RE+ R+ RERERERE RER+R+R+ ERERE++ ERER
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Query: 420 EREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA 479
ERE E+DK+R+RE D + +RR+ ER+ R+ + Q R + ERK+ R+ E+E
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERE-RQTDRKRQRRTERDRETERKRERQRERER 309
Query: 480 EREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKRE 539
ERE R+RE +E +R +E + + DR+ + +R R R+ EM+ ER+R+
Sbjct: 310 ERERNRKRERERERERERERQRETERDREKER--------ERKRKRQTEMDR-ERNRQTG 360
Query: 540 KEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
+E + + E D + +R E+E +R R Q ++E ++E++ + ++E E++RE
Sbjct: 361 REGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRER 420
Query: 600 PMEEEEE 606
+ E E
Sbjct: 421 EKDRESE 427
Score = 217 bits (552), Expect = 4e-56
Identities = 132/380 (34%), Positives = 220/380 (57%), Gaps = 50/380 (13%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGK-KEKERQEIEKERRERERERERERERRER- 325
+ E +++ +E + D ++ + E+ + KE+ER++ +ERRERER+RE+E + +R
Sbjct: 146 QRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRH 205
Query: 326 -EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
ER RERERERE E E ER+R+ DR+RDR ++ +R+R+++ +R+R ER ++R+K+R R
Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERE 265
Query: 385 REKSRDR-----EREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
R++ RDR ERER+ +R+R+R ER+RE ER+RER+RERERERE+++KR+RE + E
Sbjct: 266 RDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERER 325
Query: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
ER++ + REKE RERK+ R+ E + ER + RE ++A+R +E
Sbjct: 326 ERERQRETERDREKE------------RERKRKRQTEMDRERNRQTGREGRRQAERERE- 372
Query: 500 LEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPD 559
++R RDR+ E +ER+R R+++ +E E + D
Sbjct: 373 -------------------RERERDRQSAREREERERDRDRDRQKE------RERQTEKD 407
Query: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRP 619
+ QR E E++R+ + +E E E ++EK++ RE E + + + K +
Sbjct: 408 RDGQR---ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLY 464
Query: 620 ISSAP-SVSSASGNATPNTP 638
++ P + S + PN P
Sbjct: 465 VNPPPRTARSGVVQSDPNRP 484
Score = 213 bits (541), Expect = 8e-55
Identities = 124/320 (38%), Positives = 196/320 (61%), Gaps = 43/320 (13%)
Query: 296 GKKEKERQEIEKER-RERERERERERERREREREREREREREKEKERERERERDRDRDRT 354
G+ K+ ++ER R++ERER RE+ + ERE +R+RER REK++ R+R+R R+R RDR
Sbjct: 43 GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDRE 102
Query: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERE 414
KER+R DRERDR R++ER+ + ++R RE R R+R+ + +RERER+R+ E+ERER+
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE 474
+RER+R+ ER + K+R+RE++ + ERR+ ER+ REKE ++R ER + RE
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQ---ERRERERQ-REKENKTEDRHS-----ERGRERE 213
Query: 475 YEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME---A 531
E+E E E ER+R+ +E R + K R+REK+ E A
Sbjct: 214 RERETETETERKRQTDRERDRQR----------------------KTEREREKQAERERA 251
Query: 532 DERDRKREKE-ELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEK 590
ER+ +R+KE E E R R D D + E++ +R+RQ + +++ E+E + E +
Sbjct: 252 SERETERDKERERERDRDR-------DRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304
Query: 591 QEKEEKREEPMEEEEEPEQK 610
+E+E +RE + E E E++
Sbjct: 305 RERERERERNRKRERERERE 324
Score = 210 bits (534), Expect = 5e-54
Identities = 142/404 (35%), Positives = 222/404 (54%), Gaps = 46/404 (11%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER---RE 324
E E +K RE + R+ K E+ ++ +ER+ + E ER+R+ +RER R+
Sbjct: 178 EREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRK 237
Query: 325 REREREREREREKEKERERERERDRDRDRTKERDRDR---DRERDRDRDRERSSDRNKDR 381
ERERE++ ERE+ ERE ER+++R+R+R ++RDRDR +RER DR R+R ++R+++
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297
Query: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKR----DREEDE 437
R RE+ R+RERERER R+RERERERERERER+RE ER+RE+ERE+ +KR DRE +
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357
Query: 438 EDAYE-RRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
+ E RR+ ER+ + ++ + E RER + R+ +KE ER+ E+ R+ +E ++
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE-ELEEIRQRLLAEGH 555
+E +D + +R ++R R+REK+ + ERDR+R+ + + R+R +
Sbjct: 418 REREKDRESERG----------RERGREREKQ-KGRERDRERQTDRQAGRQRKRSTLYVN 466
Query: 556 PDPDAELQRMEQEAERR--RQPQIKQEPESEEEEEEK------------QEKEEKREEPM 601
P P + Q R R + K PE + + + +R EP
Sbjct: 467 PPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPR 526
Query: 602 EEEEEPEQKPCLKP-----TLRPISSAPSVSSASGNATPNTPGD 640
E+ + +P T P+S APSV TPGD
Sbjct: 527 LGEKRGQGGEGRRPSGGFGTENPLSQAPSVFP----GPRYTPGD 566
Score = 196 bits (499), Expect = 6e-50
Identities = 111/329 (33%), Positives = 186/329 (56%), Gaps = 8/329 (2%)
Query: 171 EWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESD 230
E + +++ G R + E D E +R Q + R E +
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187
Query: 231 SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKK 290
R++++EK+ R +E E E +++ RE + R T ++
Sbjct: 188 RRERERQREKENKTEDRHSERGR------ERERERETETETERKRQTDRERDRQRKTERE 241
Query: 291 LEEEKGKKEKERQEIEKER-RERERERERERERREREREREREREREKEKERERERERDR 349
E++ ++ +E E+++ RERER+R+R+R+RR++ERER+ +R+R++ ER+RE ER R
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKR 301
Query: 350 DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER 409
+R R +ER+R+R+R+R+R+R+RER +R ++ R REK R+R+R+R+ E +RER R+ R
Sbjct: 302 ERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGR 361
Query: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
E R+ ERERERERER++ R+REE E D R+ ER+ R+ E + + + RER
Sbjct: 362 EGRRQAERERERERERDRQSAREREERERDRDRDRQKERE-RQTEKDRDGQRETEKQRER 420
Query: 470 KKTREYEKEAEREEERRREMAKEAKRLKE 498
+K RE E+ ER ER ++ +E R ++
Sbjct: 421 EKDRESERGRERGREREKQKGRERDRERQ 449
Score = 177 bits (450), Expect = 3e-44
Identities = 111/328 (33%), Positives = 181/328 (55%), Gaps = 38/328 (11%)
Query: 309 RRERERERERERERRERERERERE-REREKEKERERERERDRDRDRTKERDRDRDRERDR 367
RR +E R R + ++ + + RER ++KERER RE+ R +RE DR
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREK-----------RQTERETDR 77
Query: 368 DRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE--------- 418
R+R R DR++ R R RE+ RDRE+ERER+ +RER+R+RE+ER R++ERE
Sbjct: 78 KRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER 137
Query: 419 ---------REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
RERER+R+ +K+R+R+ D E + + +K RE+E QER + RE+
Sbjct: 138 GRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREK 197
Query: 470 K-KTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKE 528
+ KT + E RE ER RE E +R ++ + D R + A ++R +RE E
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 529 MEAD---ERDRKREKEELEEIRQRLL---AEGHPDPDAELQRMEQEAERRRQPQIKQEPE 582
+ + ERDR R+++ ++ R+R + + D E +R ++E +R R+ + ++ +
Sbjct: 258 RDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER-KRERQRERERERERNRK 316
Query: 583 SEEEEEEKQEKEEKREEPMEEEEEPEQK 610
E E E ++E+E +RE + E+E E+K
Sbjct: 317 RERERERERERERQRETERDREKERERK 344
Score = 162 bits (410), Expect = 1e-39
Identities = 109/325 (33%), Positives = 169/325 (52%), Gaps = 53/325 (16%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI-KGAIE 212
EK+ + D + + Q + + K++ N + + E ++E K D+ +G
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQER---RERERQREKENKTEDRHSERGRER 212
Query: 213 VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEED 272
RE +E Q R++K E++ + +E + E E D
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTERERE-------------KQAERERASERETERD 259
Query: 273 KRDLISREISKFRDTHKK-LEEEKGKKEKERQEIEKE---RRERERERERERER---RER 325
K R+ + RD +K E + +K + R E ++E +RER+RERERERER RER
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 326 EREREREREREKEKERERERERDRDR----------------------DRTKERDRDRDR 363
ERERERERER++E ER+RE+ER+R R +R +ER+R+RDR
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR 379
Query: 364 -------ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE 416
ER+RDRDR+R +R + + R+ R+ E++RERE++RE ER RER RERE++
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQ 439
Query: 417 REREREREREKDKKRDREEDEEDAY 441
+ RER+RER+ D++ R+ Y
Sbjct: 440 KGRERDRERQTDRQAGRQRKRSTLY 464
Score = 114 bits (284), Expect = 5e-25
Identities = 81/252 (32%), Positives = 127/252 (50%), Gaps = 28/252 (11%)
Query: 380 DRSRSREKSRDRERERER----------ERERERERERERERER---ERERERERERERE 426
D SR R S++ R R +RER R++ERER RE+ ERE +R+RER RE
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 427 KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486
KD+ R R+ E +R K + ++E Q +ER + +E E+E ERE ER
Sbjct: 85 KDRHRKRDRHRERQRDREKERERQTDRERDRQRE------KERNRQKERERETEREGERG 138
Query: 487 REMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD-----ERDRKREKE 541
R+ + +R +E D + +R+ +R R +E+E E + ER+R+REKE
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198
Query: 542 ELEEIRQRLLA---EGHPDPDAELQRMEQ-EAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
E R E + + E +R Q + ER RQ + ++E E + E E E+E +R
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258
Query: 598 EEPMEEEEEPEQ 609
++ E E + ++
Sbjct: 259 DKERERERDRDR 270
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/103 (25%), Positives = 50/103 (48%), Gaps = 5/103 (4%)
Query: 516 SALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575
S ++ L K+ + D+R+R R+KE E R++ E D E +R E++ R+R
Sbjct: 36 SPRRRGLGQAHKDADGDDRERNRQKER-ERRREKRQTERETDRKRE-RRREKDRHRKRD- 92
Query: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLR 618
+ + E+E++ + ++ + E+E QK + T R
Sbjct: 93 --RHRERQRDREKERERQTDRERDRQREKERNRQKERERETER 133
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 191 bits (485), Expect = 2e-48
Identities = 122/367 (33%), Positives = 205/367 (55%), Gaps = 30/367 (8%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
E D RD + R + + + + ++ I + R E ER+ RE R +R
Sbjct: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVD 669
Query: 330 EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSR 389
+R ER +E++RERER+R+R+R+R +ERDR+R++ER+ +R+R R +R +++ R RE+ R
Sbjct: 670 DRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR 729
Query: 390 DRERERERERERERERERERERER-EREREREREREREKDKKRDREEDEEDAYERRKLER 448
DR+ +RERERERER+RE+ERERER ERERERERERERE++++R+RE E ER + +R
Sbjct: 730 DRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERER-QR 788
Query: 449 KLREKEAAYQERL-KNWEIRERKKTREYEKEAEREEERRREMA----KEAKRLKEFLEDY 503
+K+ +R K EIRE + R+ E + ++ R E + + KR +E D
Sbjct: 789 DWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDS 848
Query: 504 D-----DDRDD----------PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ 548
D DD+++ P+ R + DR+ + ++R +R KE +
Sbjct: 849 DAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER-KESSRRYEE 907
Query: 549 RLLAEGHPDPDAELQRME-QEAERRRQPQIKQEPESEEEE------EEKQEKEEKREEPM 601
+ L E D + ++ E E+ R R I +SE+ E +E ++K + +++P+
Sbjct: 908 QELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPI 967
Query: 602 EEEEEPE 608
++++E +
Sbjct: 968 KKKKEDD 974
Score = 163 bits (413), Expect = 5e-40
Identities = 126/487 (25%), Positives = 233/487 (47%), Gaps = 76/487 (15%)
Query: 170 DEWKAKKKASNGNARPETVTNDDE-----EALDEETKRRDQMIKGAIEVLIREYSSELNA 224
D W+ + + PE D E E RRD RE ++
Sbjct: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDN----------RERDQRPSS 643
Query: 225 PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKF 284
P + + ++ E++E+ ++ +D+RD +RE +
Sbjct: 644 PIRHQGRNDELERDERREE---------------------RRVDRVDDRRDERARERDRE 682
Query: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERER-REREREREREREREKEKERER 343
R+ ++ E E+ ++E++R+ ++ ERER RERERER +ER+RER+R+R+ ++E+ERER
Sbjct: 683 RERDRERERER-ERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
Query: 344 ERERDRDRDRTK-ERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERE 402
ER+R+++R+R + ER+R+R+RER+R+R+RER +R ++R + RE+ RD E + + +R
Sbjct: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
Query: 403 RERERERERERERERERERERE-----------REKDKKRDREEDEEDAY--------ER 443
+RE RE R+ ER+ + R+ K+R + DAY +
Sbjct: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861
Query: 444 RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDY 503
R L + +R +E+ E R+ + +E +++ ER+E RR E + LKE +
Sbjct: 862 RLLSQVVRPQESRSLSPSHLTEDRQ-GRWKEEDRKPERKESSRR---YEEQELKEKVSSV 917
Query: 504 DDDRDDPKYYRGSALQ-------KRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
D R+ + S ++ + DRE A + ++K+ K + + I+++
Sbjct: 918 DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK------K 971
Query: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ-KPCLKP 615
+ D ++R E + +++ EK+ K+ K + + +EE +Q K P
Sbjct: 972 EDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGP 1031
Query: 616 TLRPISS 622
PI++
Sbjct: 1032 RTPPITT 1038
Score = 126 bits (317), Expect = 7e-29
Identities = 131/536 (24%), Positives = 219/536 (40%), Gaps = 91/536 (16%)
Query: 149 DLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIK 208
D+ +G+K K K K +++E K +G R D E ++ K R
Sbjct: 273 DIALGKK---YKEKYKVKDRIEE-----KTRDGKDRGR----DFERQREKRDKPRSTSPA 320
Query: 209 GAIEVLI--REYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL----IPYPLITKE 262
G I R +SS + S P ++K ++R PL PYP +
Sbjct: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
Query: 263 DINAIE--------MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERER 314
+ M E R R H++ E+ +GK+++E+ E+ E+++
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ 440
Query: 315 ERERE----------RERREREREREREREREKEKERERERERDRDRDRTKERD------ 358
R+ R+RR+ R+R R+ R+ RD RD + RD
Sbjct: 441 SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500
Query: 359 -RDRDRERDRD-RDRERSSDRNKDRSRS-------REKSRDRERERERERERERERERER 409
RD RDR+ RD R D + SRS E SR R R R R
Sbjct: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
Query: 410 ERERERERE-----------------------------REREREREKDKKRD-REEDEED 439
R R R E R ER++ +RD R++ +
Sbjct: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
Query: 440 AYERRKLERKLREKE---------AAYQERLKNWEIRERKKTREYEKEAEREEERRREMA 490
++ERR ER R+ +Q R E ER++ R ++ +R +ER RE
Sbjct: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
Query: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
+E +R +E + + +RD + ++R R+RE+E E ERDR+R+++ + +
Sbjct: 681 RERERDRERERERERERDREREKERELERERARERERERE-KERDRERDRDRDHDRERER 739
Query: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
E + + E +R E+E ER R+ + ++E E E E +++KE +R+ E++++
Sbjct: 740 ERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDK 795
Score = 100 bits (250), Expect = 4e-21
Identities = 89/348 (25%), Positives = 158/348 (45%), Gaps = 27/348 (7%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
++ R + S+ R+ K LE G+++ ++++ R +R+ R R
Sbjct: 1220 DQSGRKRVLHSGSRDREKTKSLEIT-GERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRS 1278
Query: 330 EREREREKEKE------RERERERDR-DRDRTKERDRDRDRERDRDRDRERSSDRNKDRS 382
E +R+ R+R +ERDR + DR +ER+R R+R+ DRD ++ RN+DR
Sbjct: 1279 SPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRD 1338
Query: 383 RSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYE 442
R RE+ R+RER++ R+ +RERER ER+R+R+R+R E + + R E + +
Sbjct: 1339 RLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
Query: 443 RRKLERKLREKEAAYQERLKN--WEIRERKKTREYEK----EAEREEERRREMAKEAKRL 496
R LE R+ A +ER+ ++ ++T + E+ EA +E + +
Sbjct: 1399 ERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGA 1458
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
E E DD D + D EK + + ++ + ++ ++ L HP
Sbjct: 1459 GEGYEPISDDELD---------EILAGDAEKREDQQDEEKMPDPLDVIDVDWSGLMPKHP 1509
Query: 557 ----DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600
+P A L + A R K+ SE + K+ + E+P
Sbjct: 1510 KEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKP 1557
Score = 96.3 bits (238), Expect = 1e-19
Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 4/195 (2%)
Query: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
+++ KR SR S R + + E +RQ + R+R +ER+R E +RE
Sbjct: 1251 IDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRE 1310
Query: 329 REREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
RERER +++E +R+ ++D R+R ++R R+R+RER+RD+ R+ +R + S S E+
Sbjct: 1311 RERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERD 1370
Query: 389 RDRERERERER---EREREREREREREREREREREREREREKDKKR-DREEDEEDAYERR 444
RDR+R+R E E + E + E E ER+ E DK+R D++ +E
Sbjct: 1371 RDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEET 1430
Query: 445 KLERKLREKEAAYQE 459
+ EA E
Sbjct: 1431 NKSERTESLEAGDDE 1445
Score = 90.9 bits (224), Expect = 4e-18
Identities = 98/361 (27%), Positives = 145/361 (40%), Gaps = 66/361 (18%)
Query: 265 NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKK---EKERQEIEKERRERERERERERE 321
N E+ R + K H +E+ + +K +K + R R R R
Sbjct: 1149 NTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRS 1208
Query: 322 RRERERERERE-------------REREKEKERERERERDRDRDRTKERDRDRDRERDRD 368
R + R+REK K E ER D+ K + R DR
Sbjct: 1209 PSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQ 1268
Query: 369 RDRERSSDRNK---DR----------SRSREKSRDR---ERERERERERERERE------ 406
R SS R+ DR SR R + RDR +RERERER R+RE
Sbjct: 1269 DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDAD 1328
Query: 407 ----REREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK 462
R R+R+R RERERERER++ +D R+RE D+ ER + + R E++ E +K
Sbjct: 1329 KDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVK 1388
Query: 463 NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRL 522
E + E E E + E R +A + +R+ + L + K R +L+
Sbjct: 1389 RCEAK-----LEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE--A 1441
Query: 523 RDREKEME--------ADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQ 574
D E +++ A E +EL+EI DAE + +Q+ E+
Sbjct: 1442 GDDESKLDDAHSLGSGAGEGYEPISDDELDEILA---------GDAEKREDQQDEEKMPD 1492
Query: 575 P 575
P
Sbjct: 1493 P 1493
Score = 54.7 bits (130), Expect = 4e-07
Identities = 73/360 (20%), Positives = 129/360 (35%), Gaps = 42/360 (11%)
Query: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK-EKERER 343
R + + + + + +RQ+++ E ++R E R+E R R RE+E K KER
Sbjct: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
Query: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
E E + T D D + + + D E S + + + + RE + + E+ E
Sbjct: 136 ESEEENVEWETNRDDSD-NGDINYDYVHELSLEMKRQKIQ-RELMKLEQENMEKREEIII 193
Query: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
++E E R + R+ K KR A K +RK + ++ +N
Sbjct: 194 KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSA---SKKDRKTSAVSSPLLDQQRN 250
Query: 464 WEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLR 523
KT + +K+ R + ++ K++ E Y +++
Sbjct: 251 ------SKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKY-----------------KVK 287
Query: 524 DREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES 583
DR +E D +DR R+ E E R + R A + P + S
Sbjct: 288 DRIEEKTRDGKDRGRDFERQREKRDK-------------PRSTSPAGQHHSPISSRHHSS 334
Query: 584 EEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESP 643
+ ++ Q+ P R S PS S +S + P SP
Sbjct: 335 SSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSP 394
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/222 (16%), Positives = 95/222 (42%), Gaps = 6/222 (2%)
Query: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKG-KKEKERQEIEKERRERERERERERER 322
++ + ++ R L +++ R K E+ K +KE R+ E+E +E+ +++RE+
Sbjct: 864 LSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQ 923
Query: 323 RE-----REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
E R R ++ + E +R D ++ + K + + ++++ D ER +
Sbjct: 924 TEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIE 983
Query: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437
+ ++++ E++R++ + + E ++ +++R +EE
Sbjct: 984 TTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELV 1043
Query: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA 479
E + + ++KE + ++ +R + E E A
Sbjct: 1044 EMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTA 1085
Score = 37.0 bits (84), Expect = 0.077
Identities = 42/229 (18%), Positives = 86/229 (37%), Gaps = 31/229 (13%)
Query: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437
N+D R ++R + E + + + +++R R R R R
Sbjct: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSN-RSHTSGRLRSPSN 1211
Query: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLK 497
+ A+ + + ++R+ + R+R+KT+ E ER+ R + K + +
Sbjct: 1212 DSAHRSGD--------DQSGRKRVLHSGSRDREKTKSLEITGERKS--RIDQLKRGEPSR 1261
Query: 498 EFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPD 557
D D R +++ R D RDR +E++ E R+R
Sbjct: 1262 STSSDRQDSRSHSSRRSSPESDRQVHSRSGSF--DSRDRLQERDRYEHDRER-------- 1311
Query: 558 PDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
E ERR Q + + +++++ ++++ RE E E +
Sbjct: 1312 ----------ERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERD 1350
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 185 bits (470), Expect = 1e-46
Identities = 128/465 (27%), Positives = 248/465 (53%), Gaps = 52/465 (11%)
Query: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIF 245
ETV +EE L EE +R + ++ E L + EL QE + ++ ++E++
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ---- 305
Query: 246 RRFPVAPLIPYPLITKEDINAIEMEEDKRDLISR--EISKFRDTHKKLEEEKGKKEKERQ 303
L K++ E +E++R+ R + + R+ + E+E+ ++++ R+
Sbjct: 306 ------------LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 304 EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR 363
E E+ERRE++ RE+E ERRE++ RE++ RE++ RE++ R++ R ++ R++
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE---------RERERERERERERE 414
R++ RE+ R ++ R +K RE+ +RE RE E ER + R+
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 415 RERERERERER-------EKDKKRDREEDEEDAYERRKLER-----KLREKEAAYQERLK 462
++ +R++E ER E++++R+++E E R + ER K +E+E Q+RL+
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 463 NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD---RDDP------KYY 513
+ + R++ E+ +REEE+R E + +RLK E+ D R++ K
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Query: 514 RGSALQKRLRDREKE-MEADERDRKR-EKEELEEIRQRLLAEGHPDPDAELQRMEQEAER 571
+ L++RL+ E E +E +ER +R ++EE EE R++ L + + Q++ +E +
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 572 RRQPQIKQEPESE--EEEEEKQEKEEKREEPMEEEEEPEQKPCLK 614
RR+ ++K+E E E E+ +++ +EE+RE+ + EEE+ + + +K
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Score = 169 bits (429), Expect = 8e-42
Identities = 125/475 (26%), Positives = 243/475 (51%), Gaps = 51/475 (10%)
Query: 162 DAKTKAQLDEWKAKKKASNGNARPETVT-NDDEEALDEETKRRDQMIKGAIEVLIREYSS 220
D + Q EW+ +++ + ++ ++ EE DEE RR ++++ +R
Sbjct: 170 DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE------LRRKGR 223
Query: 221 ELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISRE 280
E Q + R ++E++++ +R V L +E E++E++ L E
Sbjct: 224 E-EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 281 ISKFRDTHKKLEEE----------KGKKEKERQEIEKERRERERERERERERRERERERE 330
+ R ++ E++ + K+E+ER+E ++ERRE++ RE++ ERRE++ RE
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 331 REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
+E RE++ RE+E ER + R ++ + R+++ R++ R +++ RE+
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 391 REREREREREREREREREREREREREREREREREREKDKKRD----REEDEEDAYERRKL 446
RE++ RE++ RE++ RE++ RE+E ER ++ + ++R+ RE++E + +R+
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMA----KEAKRLKEFLED 502
E + E+E Q+ ++ E R++ + E+E RE++ RRE +E +R +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 503 YDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAEL 562
+++R LQ+RLR E+ +RE+EE E + E + +
Sbjct: 523 EEEER----------LQQRLRS--------EQQLRREQEERREQLLKREEEKRLEQERRE 564
Query: 563 QRMEQEAERRRQPQIKQEPESEE-----EEEEKQEKEEKRE--EPMEEEEEPEQK 610
QR+++E E RR +K+E E + E+EE+ E+ KRE E +E+EE EQ+
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Score = 159 bits (403), Expect = 8e-39
Identities = 130/517 (25%), Positives = 252/517 (48%), Gaps = 66/517 (12%)
Query: 142 RALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEE-- 199
R R +LQ E++LL + K + Q E + +++ E + ++E+ L EE
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREE--------EELQQEEEQLLGEERE 1069
Query: 200 TKRRDQMIKGAIEVLIREYSSELNAPSQESD---SHPRKKKKEKKEDIFRRFPVAPLIPY 256
T+RR + L R+Y E +E P K++++++E R
Sbjct: 1070 TRRRQE--------LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERERE 315
L+ +E E +++ E+ + + + E EK ++++ ERQ E+E ++E E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 316 RERERERREREREREREREREKEKERERERERDRDRDRT--------------------- 354
+ E+ +R +ERER+ E+E +R++ ++R RD D+
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Query: 355 -KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER 413
K R+ ++ R+ + + R+R S ++ ++ RDRE+ER R ++R+R E + ER
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER 1301
Query: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTR 473
E ++E +R + +++K+ E+ E+ R++ +RK RE+E QER + +R +++ R
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER-EEQPLRRQERDR 1360
Query: 474 EYEKEAEREEERRREMAKEAKRL------KEFLEDYDDDR-DDPKYYRGSALQKRLRDRE 526
++ +E R +E+ R+ +E +RL ++FL++ R + + ++ R+ E
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 527 KEMEADERDRK------------REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQ 574
+++ ERDRK RE++ LEE Q+L E H E Q +++ E++
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEE-EQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 575 PQIKQEPESEEEEE-EKQEKEEKREEPMEEEEEPEQK 610
Q + EEE++ +QE++ K E +EPE+K
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516
Score = 158 bits (400), Expect = 2e-38
Identities = 117/482 (24%), Positives = 228/482 (47%), Gaps = 70/482 (14%)
Query: 171 EWKAKKKASNG----NARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPS 226
+W+A++K+ G +ARP + + EE ++R+Q P
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF----------------LPE 813
Query: 227 QESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRD 286
+E R++++E++++ L E+ ++ E + L E D
Sbjct: 814 EEEKEQRRRQRREREKE--------------LQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 287 THKKLEEEKGKKEKERQEIEKERRERE--------------------RERERERERRERE 326
++ +E+ + +K R ++E+ER+ R +E E E +R ERE
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 327 REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
+ R +E+ER+ +E + ++E ++ +E+ R ++RER +D++ + E
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKL 446
K R +ERE++ E E ++E E+ ERE+ R +E ER+ KK + +++EE +
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506
+R+L+E+E Y+E E ++ E ERE RR+E+ ++ ++ +E ++ +
Sbjct: 1040 KRRLQERERQYREE------EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 507 -RDDPKYYRGSALQKRLRDREKEMEADER--DRKREKEELEEIRQRLLAEGHPDPDAELQ 563
R++P+ R +++ R+ E+ + +E+ +REK +E+ ++ E + E
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 564 RMEQEAERRRQP---QIKQEPESEEEEE----EKQEKEEKREEPMEEEEEPEQKPCLKPT 616
E+ +RRRQ Q ++E E ++EEE E+QEK + E EEE Q+ K
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 617 LR 618
R
Sbjct: 1214 YR 1215
Score = 152 bits (385), Expect = 1e-36
Identities = 122/482 (25%), Positives = 238/482 (49%), Gaps = 64/482 (13%)
Query: 166 KAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP 225
+ Q +E + ++ R E +++ E+ RR+Q ++ + L RE
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQ 424
Query: 226 ---SQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
QE + H +K ++E++E +R +E++RD + RE
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKR---------------------EQEERRDWLKREEE 463
Query: 283 KFRDTHKKLEEE-KGKKEKERQE----IEKERRERERERERERERREREREREREREREK 337
R ++ +++ K +E+ER+E +E+E R ++ER ++ RRE+E RE+ +R++
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR-SRSREKSRDRERERE 396
E+ER ++R R + R ++ +R R++ R+ ++ +R + R R +E+ RD+ +RE
Sbjct: 524 EEERLQQRLRSEQQLRREQEER-REQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
ER ++R + + ER +R + E ER +++++ R + EE ERR+ K E+E
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD------P 510
Q++L+ + R++ + E+E ER E+R + +E +R +E E+ + + P
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 511 KYY---------RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAE 561
K+ R S + R R +E + E++ KR + E E++ + H E
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE-SELQWQEEERAHRQQQEE 761
Query: 562 LQR--------MEQEAERRRQ-----PQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
QR E+++ER RQ P ++++ E + EE+Q++E++ + EEEE E
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF---LPEEEEKE 818
Query: 609 QK 610
Q+
Sbjct: 819 QR 820
Score = 152 bits (383), Expect = 2e-36
Identities = 128/488 (26%), Positives = 233/488 (47%), Gaps = 69/488 (14%)
Query: 162 DAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSE 221
D K + QL+E + K++ A+P AL E+ ++ Q+++ E L RE +
Sbjct: 871 DQKWRWQLEE-ERKRRRHTLYAKP---------ALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 222 LNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEME----EDKRDLI 277
QE ++ ++++E + R +E E E +DK+
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLRE------------EREKRRRQERERQYRKDKKLQQ 968
Query: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKE-----RRERERERERERERR--------- 323
E + K+ +E+ KK +E +E+++E R ERE+ R +E ER+
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 324 --------EREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSS 375
ERE+ R +ERER+ +E E ++E ++ +E R ++ ER ++ E
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 376 DRNKDRSRSREKSRDRERERERERERERERERER----EREREREREREREREREKDKKR 431
+ + EK R +ERER+ E E ++E E+ ERE+ R +E ER+ E++ ++
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 432 DREE---DEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRRE 488
+ E+ +E + R++LER+ RE+E QE + + K+ +E E++ EEE +R+
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 489 MAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ 548
K+ R +D R D K+ + +RD + + E ++ R+ E+ ++R
Sbjct: 1209 KRKQRYR-------DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED-SQLRD 1260
Query: 549 RLLAEGHPDPDAELQRMEQEAERRR-QPQIKQEPESEEEEEEKQEKEEKREEPMEEE--- 604
R + E Q ++E ERRR Q + + PE E+ E E+Q++ ++R+ +EE
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 605 --EEPEQK 610
EE E+K
Sbjct: 1321 LREEREEK 1328
Score = 148 bits (373), Expect = 2e-35
Identities = 92/344 (26%), Positives = 188/344 (54%), Gaps = 16/344 (4%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKE-RQEIEKERRERERERERERERRERERE 328
EED+R +F ++LEEE G++ ++ RQE E+E E E + E++ +R+R+
Sbjct: 116 EEDQR--------RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167
Query: 329 REREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
R R+ E ++++ +ERE R + + + + E D ++ R + + R + RE+
Sbjct: 168 R-RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED--AYERRKL 446
+ + RER+ +E E + R+RE +E E+ +E E ++R+ +E+EE ER++L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506
R+ +E+E Q + ++R +++ E++ ER E++ R +E +R ++ L ++
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR-EQQLRREQEE 345
Query: 507 RDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRME 566
R + + R ++R + +E E + R+++ +E+ Q+L E + +L+R
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-- 403
Query: 567 QEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
E + RR+ Q+++E + E++ ++E+EE+R E E+E EQ+
Sbjct: 404 -EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446
Score = 143 bits (360), Expect = 8e-34
Identities = 97/406 (23%), Positives = 203/406 (50%), Gaps = 60/406 (14%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRE---------------- 311
E+ E + +E + RD ++ +EE ++ +E QE E+ R E
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRR-DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205
Query: 312 -----------------RERERERERERRERERERERERE---------REKEKERERER 345
RE ++++ RER++R + E E+E +E+EK +E E
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 346 ERDRDRDRTKERDRDRDRE--RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
+R R+ +E+ R +R+ R ++ E+ R + + R K + RE++ ER ++
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
ER ++E RE++ RE+E RE+ +R++EE+ + RR+ E + RE++ +++L+
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 464 WEIRERKKTREYEKEAEREEERRREM----AKEAKRLKEFLEDYDDDRDDPKYYRGSALQ 519
+ R++ E++ RE++ RRE ++ +R ++ + +++R + K+ + Q
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 520 KRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER----RRQP 575
+ R++E+ + +R+ + E+ E E +Q+L + + ++E+E R RR+
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 576 QIKQEPESEEEEEEKQEKEEKR-------EEPMEEEEEPEQKPCLK 614
Q+++E E E+ K+++EE+R E+ + E+E ++ LK
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Score = 141 bits (356), Expect = 2e-33
Identities = 118/499 (23%), Positives = 245/499 (49%), Gaps = 34/499 (6%)
Query: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNG-----NARPET 187
E E E A R D + E+K L++ + + K + E K + +P
Sbjct: 1297 EQLEREEQKEAKR--RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 188 VTNDDEEALDEETKRRDQMIKGAIEVL-IREYSSELNAPSQESDSHPRKKKKEKKEDIFR 246
D + +EE + ++Q K E +R E +E ++++++ ++D R
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 247 RFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIE 306
+F +++++ + EE+++ KF + ++L +E+ +K +E +++
Sbjct: 1415 KFREEE----QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 307 KERRERERERERERERREREREREREREREKEKERERE-RERDRDRDRTKERDRDRDRER 365
+ER E++ R+ ER+R+ E E++ R+ K RE+E R ++ +R +E + ++R
Sbjct: 1471 QEREEQQLHRQ-ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 366 DRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERER 425
R +E R ++R + R + RDR+ E + +ERE ++ +ER+R+ E ++ R
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 426 EKDKKRDREEDEEDAYE-------RRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478
++++R EDE+ R++ +RK RE E QER + R+ + + E+E
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 479 A-----EREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADE 533
ERE++ R + ++ + ++ L++ ++ + R ++ R+ E+++ E
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ-----LRRQERDRKFREEEQQLRRQE 1704
Query: 534 RDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR--RQPQIKQEPESEEEEEEKQ 591
R+RK +EE +++R++ L + + Q EQE RR R +I +E + E EE+Q
Sbjct: 1705 RERKFLQEE-QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 592 EKEEKREEPMEEEEEPEQK 610
+ ++R+ EEE+ Q+
Sbjct: 1764 LRRQERDRKFREEEQLRQE 1782
Score = 140 bits (353), Expect = 5e-33
Identities = 139/575 (24%), Positives = 261/575 (45%), Gaps = 106/575 (18%)
Query: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDD 192
E K E R RL + + +LL + + + + +L + +++ R E +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR-EQEERLEQRLKREEVERLEQ 612
Query: 193 EEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAP 252
EE ++ KR + + ++L E E + R++++ K+E+ R
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 253 LIPYPLITKEDINAIEMEEDKRDLISREISKFR------------------------DTH 288
+ +E A E +E R+ I I K++
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 289 KKLEEEKGKKEKERQEIEKERRERERERERER----------ERRERERER--------- 329
++ EE++ ++E E Q E+ER R+++ E +R E+ ER R+R
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 330 ERER-----------------EREKEKERERERERDRDRDRTKERDRDRDRERDRD-RDR 371
+RER E EKE+ R + RER+++ +E ++ + RER + ++
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 372 ERSSDRNKDRSRSREKSRDR------ERERERERE-------------------RERERE 406
E +++R RS+E+ RD+ E ER+R R +E E E
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 407 REREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEI 466
+RE ERE+ R +E+ER+ ++++ +EE++ ER K R+ RE++ ++L+ E
Sbjct: 913 LQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 467 R------ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
+ E+++ +E EK+ EEE ++E E + L+E E + +Y + LQ+
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQE---EEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 521 R----LRDREKEMEADERDRK-REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575
LR+ ++ ER+R+ RE+EEL++ ++LL E +R E E + R++
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER----ETRRRQELERQYRKEE 1084
Query: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
+++QE E EE ++ + ++RE EEEE +Q+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Score = 140 bits (353), Expect = 5e-33
Identities = 118/500 (23%), Positives = 248/500 (49%), Gaps = 56/500 (11%)
Query: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDD 192
E + + R R +LQ E++LL + K + Q E + +++ E + ++
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE--------EELQQEE 1120
Query: 193 EEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAP 252
E+ L EE ++R + + L R+Y E +E + +K +++++ R++
Sbjct: 1121 EQLLREEREKRRR------QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY---- 1170
Query: 253 LIPYPLITKEDINAIEMEEDKRDLISREISKFRDT----HKKLEEEKGKKEKERQEIEKE 308
+E+ E+++++ L+ E K R +++ EE + +K K+R E +
Sbjct: 1171 -------REEE----ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 309 RRERERERERERERRERERE-----REREREREKEKERERERERDRDRDRT----KERDR 359
R + + + E E+E R+ + RE E+ R+ E + R+R+ +D +ERDR
Sbjct: 1220 RSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Query: 360 DRDRERDRDRDRERSSDRNKDRSRSRE-KSRDRERERERERERERERERERERERERE-R 417
+++R R + RDR + +R +E K RDR+ + E++ RE E+ R +E +R+ R
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 418 E-----REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKT 472
E +ERE + + ++RDR+ EE+ + + + L E++ ++ + ++E ++
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 473 REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
R E+E + ++R R+ +E ++L D R++ + R +++ + E+++ +
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERD-RKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 533 ERDRKREKEEL--EEIRQRLLAEGHP----DPDAELQRMEQEAERRRQPQIKQEPESEEE 586
+ RE+E+L E Q+L + + + +L+R E++ + R Q QEPE +
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 587 EEEKQEKEEKREEPMEEEEE 606
EEE+Q ++R+ +EE+
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQ 1538
Score = 139 bits (349), Expect = 1e-32
Identities = 128/511 (25%), Positives = 254/511 (49%), Gaps = 59/511 (11%)
Query: 135 KEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEE 194
+EPE R R + Q E++ L + + + + E + +++ E V ++E+
Sbjct: 1096 EEPEKRRRQER---ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 195 ALDEETKRR-----------DQMIKGAIEVLIREYSS----ELNAPSQESDSHPRKKKKE 239
L EE ++R ++ ++ E L+RE E +E + R+K+K+
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 240 KKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTH-KKLEEEKGKK 298
+ D +R + E NA+ ++K RE +FR +L + + ++
Sbjct: 1213 RYRDEDQRSDLKWQWE-----PEKENAVR--DNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 299 EKERQEIEKERRERERERER---------ERERRERERERE-REREREKEKERERERERD 348
+ + E++ R+RE+ER R E E+ ERE ++E + R+R+ ++E++ RE
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS--REKSRDRERERERERERERERE 406
++ R +E DR E ++RE R ++R R E+ R +E+ R+ E +R R
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 407 REREREREREREREREREREKDKKRDREE---DEEDAYERRKLERKLREKEAAYQERLKN 463
+ERER+ +E ++ R +ERE+ ++DR+ +EE R++ +RK RE+E
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ-------- 1437
Query: 464 WEIRERKKTREY-EKEAEREEERRREMAKEAKRLKEFLED--YDDDRDDPKYYRGSALQK 520
++R +++ R++ E+E + +ER R+ +E + L+E E + +RD L++
Sbjct: 1438 -QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 521 RLRD---REKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR--RQP 575
+ RD RE+E+ + E +RK +EE +++ ++ + +L+R E+ +RR R
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEE-QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
+ ++E + +E EE+Q ++R+ EE+
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Score = 138 bits (347), Expect = 2e-32
Identities = 119/523 (22%), Positives = 244/523 (46%), Gaps = 53/523 (10%)
Query: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDD 192
+ + + R +L + Q+ ++ L + + Q +E +K R + + +
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE--RREQRLKREQ 451
Query: 193 EEALD-----EETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRR 247
EE D EET+R +Q + + L R+ E + + R++++E++E RR
Sbjct: 452 EERRDWLKREEETERHEQERRK--QQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 248 FPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEK 307
+E + EE++ R + R ++ E+ K+E+E++ +E+
Sbjct: 510 EQEE--------RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR-LEQ 560
Query: 308 ERRERERERERERERRE---REREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364
ERRE+ +RE+E R + RE ER ++R + +++ER +R + + +R ++ +R R
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERE 424
+ + + ER K + + + RE++ RE+ +RE E ER E+ +RE E
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER---LEQRLKREHE 677
Query: 425 REKDKKRDREEDEEDAYERRK----------------LERKLREKEAAYQERLKNWEIRE 468
E+ ++ EE++E A ER K + K+ + + + + E E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 469 RKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKE 528
+++ RE E + + EE R+ +E +R + +++ + R SA RE++
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 529 MEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAE---RRRQPQIKQEPESEE 585
+ A+ER ++ ++ EE + + + ELQ +E+E + R R Q+++E + +
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 586 EEEEKQEKEEKREE-----PMEEEEEPEQ-----KPCLKPTLR 618
E++E++ +E+R + +EEE + + KP L+ LR
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Score = 135 bits (339), Expect = 2e-31
Identities = 108/435 (24%), Positives = 224/435 (51%), Gaps = 40/435 (9%)
Query: 192 DEEALDEETK-RRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKE--KKEDIFRRF 248
D + L+EE + RR + + E +R E +E H ++++++ ++E RR
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 249 PVAPLIPYPLITK-EDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEK 307
K + + E +++ L +E RD +LEE+K +++++ ++ +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE----RDRKFRLEEQKVRRQEQERKFME 1599
Query: 308 ERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR 367
+ ++ R+ +++ R+ER+R+ + + +E+E ++ ++RDR +E + R +ER++
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 368 D--RDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER----ERERERER 421
DR+R + + E+ + R +ER+R+ E ++ R +ERER E ++ R +
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 422 ERERE-KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
E ER+ +++++ R+E E++ R++ RK+ E+E ER + ++R +++ R++ +E +
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER-EEQQLRRQERDRKFREEEQ 1778
Query: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRK--- 537
+ER + + + ++F E+ Q R E+++ +RD K
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEE---------------QLRQEREEQQLRPQQRDGKYRW 1823
Query: 538 -REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK 596
E+ +LEE QRL E AE Q QE RR + ++ Q EEE++ +QE+E K
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ----EEEQKRRQERERK 1879
Query: 597 -REEPMEEEEEPEQK 610
REE + +++ EQ+
Sbjct: 1880 LREEHIRRQQKEEQR 1894
Score = 134 bits (336), Expect = 5e-31
Identities = 104/459 (22%), Positives = 235/459 (51%), Gaps = 51/459 (11%)
Query: 192 DEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKE-KKEDIFRRFPV 250
+EE +R + +K ++ +E +L Q+ D R+++++ +++ R+F
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLR---QDRDRKFREEEQQLSRQERDRKF-- 1432
Query: 251 APLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKL-EEEKGKKEKERQEIEKER 309
+E+ + +E +R + E ++ H+K EEE+ +E+E Q++ ++
Sbjct: 1433 ----------REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 310 RER------ERERERERERRERERE-REREREREKEKERERERERDRDRDRTKERDRDRD 362
R+R ++ R +ER+R+ RE+E R +E ER+ +E ++ + R R +E + R
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 363 RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER------E 416
+ER + R ++R ++ +E+ + +ER+R+ E ++ R +E+ER +
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 417 REREREREREKDKKRDR---------EEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
+ R +E +++ ++RDR +E EE R++ +RK E+E + + + ++R
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 468 ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREK 527
+ R++ +E + +E + + +R ++F E+ R + + +++LR +E
Sbjct: 1663 -HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 528 EMEADERDRKREKEELEEIR-----QRLLAEGHPDPDAE---LQRMEQEAERRRQPQIKQ 579
E + E ++ R++ E E++R +++L E P+ E L+R E++ + R + Q++Q
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781
Query: 580 EPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLR 618
E E ++ ++ +++ + EE + +E E +Q L+P R
Sbjct: 1782 EREEQQLRSQESDRKFREEEQLRQEREEQQ---LRPQQR 1817
Score = 132 bits (333), Expect = 1e-30
Identities = 126/518 (24%), Positives = 255/518 (49%), Gaps = 73/518 (14%)
Query: 135 KEPESTLRALRLLHDLQIGEKKLLVKVDAKT----KAQLDEWKAKKKASNGNARPETVTN 190
+E E + L+ H+ + E++L + + K+++ +W+ + + S +AR V +
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE-SEADARQSKVYS 721
Query: 191 DDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRK------KKKEKKEDI 244
+ + + +R++Q K ++ E A Q+ + R+ + +EK E
Sbjct: 722 RPRKQ-EGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 245 FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
+R P P + + A E ++ ++ + E K + ++ E EK + E +E
Sbjct: 781 RQRLSARP--PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 305 IEKERRERERERERERERREREREREREREREKEK------ERERERERD---------- 348
+ +RRER ++ + E + + ++ER R +E+ +++ E ER+R R
Sbjct: 839 -QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 349 ---RDRDRTKERDRDRDRE-RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE 404
+++ +E + + RE R++ R +E+ ++ +E+ + ERE+ R +ERE
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 405 REREREREREREREREREREREKDKKRDRE----EDEEDAYERRKLERKLREKEAAYQER 460
R+ ++++ +++ E+ E EK ++++RE E+EE E +L R+ REK R
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK-----RR 1012
Query: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
+ WE + RKK E ++EEE+ +E +RL+E Y ++ +
Sbjct: 1013 RQEWERQYRKK-----DELQQEEEQLLREEREKRRLQERERQYREEEE------------ 1055
Query: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR--RQPQIK 578
L+ E+++ +ER+ +R ++ELE RQ E + +L R E E RR R+ Q +
Sbjct: 1056 -LQQEEEQLLGEERETRR-RQELE--RQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Query: 579 QEPESEEEEEE--KQEKEEKREEPME----EEEEPEQK 610
+E E ++EEE+ ++E+E++R + +E EEEE +Q+
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Score = 132 bits (332), Expect = 1e-30
Identities = 85/327 (25%), Positives = 175/327 (53%), Gaps = 22/327 (6%)
Query: 291 LEEEKGKKEKERQEIEKERRERERERE---RERERREREREREREREREKEKERERERER 347
L+EEK + ++ + ++RR+ E +R R+R+ E +R R++ +E+E+E E+
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 348 DRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
++R ++RDR R RD + R+R + ++ R+ E+ + E E + E+ R
Sbjct: 155 SEKQERLEQRDRQR---RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211
Query: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
RE R + RE E+++++ +++DR EE+ E RK E LR++E QE
Sbjct: 212 RRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE------- 263
Query: 468 ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREK 527
E ++ RE ++E EE+ R+ +E +R E ++++ + R L+++ + +
Sbjct: 264 EPQRQRELQEE---EEQLRKLERQELRR-----ERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 528 EMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEE 587
E + + R+++ +E+ EE R++ L + + R EQE ERR Q +++ E E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 588 EEKQEKEEKREEPMEEEEEPEQKPCLK 614
+ ++E++ +RE+ + E++ ++ L+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLR 402
Score = 126 bits (316), Expect = 1e-28
Identities = 113/437 (25%), Positives = 213/437 (48%), Gaps = 37/437 (8%)
Query: 212 EVLIREYSSEL---NAPSQESDSHPRKKKKEKK--EDIFRRFPVAPLIPYPLITKEDINA 266
E L RE E + SQE R++++EK+ ++ R+F L+ + +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE----QLLQEREEQP 1352
Query: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKER--------QEIEKERRERERERER 318
+ +E R E+ K LEEE+ + +ER Q++ + RE++ ++R
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 319 ERERRERE-----REREREREREKEKERERERER---DRDRDRTKERDRDRDRERD--RD 368
+R+ RE E +ER+R+ E+++ R +ERER + ++ +ER R E ++
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 369 RDRERSSDRNKDRSRSREKSRDRERERERERERERERERERER---ERERERERERERER 425
R+ ++ + +DR E+ + R +ER+R+ + R +E ER E E++ R++ + +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 426 EKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER--KKTREYEKEAEREE 483
+++ E R+ +RK RE+E QER + R+ +K R E++ R+E
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 484 ERRREMAKEAK-RLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEE 542
+ R+ M E + R +E + +RD LQ+R E+++ ERDRK +EE
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER---EEQQLHRQERDRKFLEEE 1649
Query: 543 LEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI-KQEPESEEEEEEKQEKEEKREEPM 601
+ RQ + D D + + EQ + + Q+ +QE + + EEE+Q + ++RE
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 602 EEEEEPEQKPCLKPTLR 618
+EE+ ++ L+ R
Sbjct: 1710 LQEEQQLRRQELERKFR 1726
Score = 125 bits (313), Expect = 2e-28
Identities = 130/534 (24%), Positives = 259/534 (48%), Gaps = 69/534 (12%)
Query: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDD 192
E + + R R ++Q E++LL + K + Q E + +++ E + ++
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE--------EELQQEE 1180
Query: 193 EEALDEETKRRDQ----MIKGAIEVLIREYSSELNAPSQESDS----HPRKKK------- 237
E+ L EE ++R Q + E+ ++ Q SD P K+
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Query: 238 --KEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLIS-REISKFRDTH----KK 290
K ++ + FR+ + L +++D+ + E+ +RD R + RD H ++
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQ--SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298
Query: 291 LEEEKGK-------KEKERQEIEKERRERERERE------RERER--RERERERERERER 335
LE E+ K K +E +++ +E RE +R R+ RE E+ +ERE + R +ER
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 336 EKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
+++ E R +++ R +E R R +ER+R +E R ++R + + RDR+
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
E ++ +ER+R+ E ++ R +ERER+ +++++ R+E E +L ++ E++
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 456 AYQERLKNW-----EIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDP 510
QER + + ++R +++ R++ ++ R +E R+ +E ++L +++
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 511 KYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ------RLLAEGHPDPDAELQR 564
+ R Q+R +DR+++ +E+ R +E+EE + RQ RL + + E +
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLR-QEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 565 MEQEAERRR---QPQIKQEPESEEEEEEK--QEKEEKREEPMEE-----EEEPE 608
ME E + RR Q Q++QE + + E+E+ QE+EE++ E EEEP+
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Score = 103 bits (257), Expect = 7e-22
Identities = 87/295 (29%), Positives = 154/295 (52%), Gaps = 45/295 (15%)
Query: 330 EREREREKEKERE-RERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
E +R R KE ++R ++ D+ R + RDR + E + R R++ ++ ++ + E+S
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRR-RQKRQEQERELAEGEEQS 155
Query: 389 RDRERERERERER-EREREREREREREREREREREREREKDKKRDREE--DEEDAYERRK 445
+ER +R+R+R + E R+R+ +ERE R E + + K + EE DEE R
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 446 LERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRRE-MAKEAKRLKEFLEDYD 504
LE + + +E Q+R RER+ R +++E E+E +R + KE ++L+E
Sbjct: 216 LELRRKGREEKQQQR------RERQD-RVFQEEEEKEWRKRETVLRKEEEKLQE------ 262
Query: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDR-KREKEELEEIRQRLLAEGHPDPDAELQ 563
++P+ Q+ L++ E+++ ER +RE++E E+ +QRL E +
Sbjct: 263 ---EEPQR------QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE-------QQL 306
Query: 564 RMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLR 618
R +QE ERR Q +EE E+QE+ E++EE E++ EQ+ + LR
Sbjct: 307 RRKQEEERREQ---------QEERREQQERREQQEERREQQLRREQEERREQQLR 352
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 182 bits (461), Expect = 1e-45
Identities = 89/216 (41%), Positives = 148/216 (68%), Gaps = 7/216 (3%)
Query: 288 HKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERER 347
HK + + ++E++R EK +ER+R+R+R+RERR +E+E R R+REK+ E ER+RER
Sbjct: 69 HKDADGDDRQRERDRVR-EKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDRER 127
Query: 348 DRDRDRTKERDRDRDRERDRD--RDRERSSDRNKDRSRSREKSRDRERERERERERERER 405
++ + R +ERDR R+RERDRD ++RER +++++D R E R+R+RERE+++ERE ER
Sbjct: 128 EKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETER 187
Query: 406 EREREREREREREREREREREKDKK----RDREEDEEDAYERRKLERKLREKEAAYQERL 461
+R+R+R+ E+ERER+ +RER++ +K R RE D E E + + R+++ +
Sbjct: 188 DRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDR 247
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLK 497
+ ERKK R+ E++ ER+E+++ E +E K+ K
Sbjct: 248 ERDRKEERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 176 bits (447), Expect = 6e-44
Identities = 98/230 (42%), Positives = 145/230 (63%), Gaps = 39/230 (16%)
Query: 273 KRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER---------R 323
+RD + + K RD +K + E+ +KEKE R+RE++ E ER+R R
Sbjct: 80 ERDRVREKTEKERDRDRKRDRERRRKEKETNR----NRDREKQTEIERDREREKQKGRER 135
Query: 324 EREREREREREREKEKERERERERDRD--RDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
ER+R RERER+R++EKERER+ E+DRD R+ ER+RDR+RE+ ++R+ ER DR +D
Sbjct: 136 ERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDT 195
Query: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441
+ RE+ DRER+R+R+ + ER+RE +RE ERE +R RER+R+R++ K+RDRE D
Sbjct: 196 EKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERD----- 250
Query: 442 ERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
RK ERK +ERKK R+ E++ +++EE+RRE K
Sbjct: 251 --RKEERK-----------------KERKKERKKERKEKKKEEKRREDKK 281
Score = 172 bits (436), Expect = 1e-42
Identities = 88/221 (39%), Positives = 145/221 (65%), Gaps = 7/221 (3%)
Query: 303 QEIEKERRERERERERERERRERERERERERER---EKEKERERERERDRDRDRTKERDR 359
++ + + R+RER+R RE+ +ER+R+R+R+RER EKE R R+RE+ + +R +ER++
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129
Query: 360 DRDRERDRD--RDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
+ RER+RD R+RER DR K+R R EK RD +RE E ERER+RERE+++ERE ER+R
Sbjct: 130 QKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDR 189
Query: 418 EREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEK 477
+R+R+ E+E++++ DRE D + + + RE E R + R+R + +E ++
Sbjct: 190 DRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQ--RDRDRGKERDR 247
Query: 478 EAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
E +R+EER++E KE K+ ++ + + R+D K G +
Sbjct: 248 ERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGEGI 288
Score = 169 bits (427), Expect = 1e-41
Identities = 91/244 (37%), Positives = 158/244 (64%), Gaps = 32/244 (13%)
Query: 311 ERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRD 370
+R+RER+R RE+ E+ER+R+R+R+RE+ R +E+E +R+RDR K+ + +RDRER++ +
Sbjct: 76 DRQRERDRVREKTEKERDRDRKRDRER---RRKEKETNRNRDREKQTEIERDREREKQKG 132
Query: 371 RERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKK 430
RER +R R RE+ RDR+RE+ERER+ E++R+ +RE E ERER+RERE+++E++ +
Sbjct: 133 RER------ERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETE 186
Query: 431 RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMA 490
RDR+ + ER + + R+++ Q ++ RE ++E ERE +RRRE
Sbjct: 187 RDRDRQRDTEKERERQTDRERDRQRKTQ----------TERQRETDREGERETDRRRERQ 236
Query: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
++ R KE D + DR ++R ++R+KE + + +++K+E++ E+ ++R
Sbjct: 237 RDRDRGKE--RDRERDRK----------EERKKERKKERKKERKEKKKEEKRRED-KKRK 283
Query: 551 LAEG 554
EG
Sbjct: 284 WGEG 287
Score = 161 bits (408), Expect = 2e-39
Identities = 83/193 (43%), Positives = 129/193 (66%), Gaps = 14/193 (7%)
Query: 260 TKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER-----RERER 314
T+++ + + +R +E ++ RD K+ E E+ ++ ++++ E+ER RER+R
Sbjct: 88 TEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDR 147
Query: 315 ERERERER---------REREREREREREREKEKERERERERDRDRDRTKERDRDRDRER 365
+RE+ERER RE E ERER+REREK+KERE ER+RDR RD KER+R DRER
Sbjct: 148 DREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRER 207
Query: 366 DRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERER 425
DR R + R DR RE R RER+R+R+R +ER+RER+R+ ER++ER++ER++ER
Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER 267
Query: 426 EKDKKRDREEDEE 438
++ KK ++ +++
Sbjct: 268 KEKKKEEKRREDK 280
Score = 143 bits (361), Expect = 6e-34
Identities = 79/238 (33%), Positives = 145/238 (60%), Gaps = 33/238 (13%)
Query: 197 DEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPY 256
D+ + RD+ +RE + + ++ D R+K+KE + R
Sbjct: 75 DDRQRERDR---------VREKTEKERDRDRKRDRERRRKEKETNRNRDR---------- 115
Query: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER---RERE 313
E IE + ++ RE + RD ++ E ++ ++++ ++ EK+R RE E
Sbjct: 116 -----EKQTEIERDREREKQKGRE--RERDRGRERERDRDREKERERQTEKDRDGQRETE 168
Query: 314 RERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRER 373
ERER+RER E+++ERE ER+R+++++ E+ERER DR+R ++R +R+R+ DR+ ER
Sbjct: 169 TERERDRER-EKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGER 227
Query: 374 SSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKR 431
+DR ++R R R++ ++R+RER+R+ ER++ER++ER++ER +E+++E +R +DKKR
Sbjct: 228 ETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER---KEKKKEEKRREDKKR 282
Score = 133 bits (334), Expect = 8e-31
Identities = 81/244 (33%), Positives = 140/244 (57%), Gaps = 32/244 (13%)
Query: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER-ERERERERERERERERER 413
K+ D D DR+R+RDR RE++ ++ R R++ RDRER R E+E R R+RE++ E ER
Sbjct: 70 KDADGD-DRQRERDRVREKT-----EKERDRDRKRDRERRRKEKETNRNRDREKQTEIER 123
Query: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTR 473
+RERE+++ RERE+D+ R+RE D +R K + EK+ Q + R+R++ +
Sbjct: 124 DREREKQKGRERERDRGRERERDR----DREKERERQTEKDRDGQRETETERERDREREK 179
Query: 474 EYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD- 532
+ E+E ER+ +R+R+ KE +R DR+ + + ++R DRE E E D
Sbjct: 180 QKERETERDRDRQRDTEKERER--------QTDRERDRQRKTQTERQRETDREGERETDR 231
Query: 533 ERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE 592
R+R+R+++ +E D E R E+ + R++ + K+ E ++EE+ +++
Sbjct: 232 RRERQRDRDRGKE------------RDRERDRKEERKKERKKERKKERKEKKKEEKRRED 279
Query: 593 KEEK 596
K+ K
Sbjct: 280 KKRK 283
Score = 116 bits (290), Expect = 1e-25
Identities = 75/245 (30%), Positives = 137/245 (55%), Gaps = 20/245 (8%)
Query: 367 RDRDRERSSDRNKDRSRSREKSRDRERERERERERER-ERERERERERERERERERERER 425
R R + S R+ ++ + + +R+RER+R RE+ E+ER+R+R+R+RER R +E+
Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRER---RRKEK 107
Query: 426 EKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEER 485
E ++ RDRE+ E +R + ++K RE+E R+R + RE +++ E+E ER
Sbjct: 108 ETNRNRDREKQTEIERDREREKQKGRERE------------RDRGRERERDRDREKERER 155
Query: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREKEELE 544
+ E ++ +R E + D +R+ K + R RD EKE E +R+R R+++
Sbjct: 156 QTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQT 215
Query: 545 EIRQRLLAEGHPDPDAELQRM---EQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPM 601
E ++ EG + D +R ++ ER R+ K+E + E ++E K+E++EK++E
Sbjct: 216 ERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEK 275
Query: 602 EEEEE 606
E++
Sbjct: 276 RREDK 280
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 21/152 (13%)
Query: 458 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517
QE ++W + + K + + + +RE +R RE ++ + D D RD + R
Sbjct: 57 QESPRSWGLGQAHKDADGD-DRQRERDRVREKTEKER-------DRDRKRDRERR-RKEK 107
Query: 518 LQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI 577
R RDREK+ E ERDR+REK++ E R+R D E +R +++ E+ R+ Q
Sbjct: 108 ETNRNRDREKQTEI-ERDREREKQKGRE-RER-------DRGRERER-DRDREKERERQT 157
Query: 578 KQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
+++ + + E E E+E RE ++E E E+
Sbjct: 158 EKDRDGQRETET--ERERDREREKQKERETER 187
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 23/129 (17%)
Query: 504 DDDRDDPKYYRGSALQK--RLRDREKEMEAD--------------------ERDRKREKE 541
D D DD + R +K + RDR+++ + + ERDR+REK+
Sbjct: 71 DADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQ 130
Query: 542 ELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPM 601
+ E + E D D E +R E++ E+ R Q + E E E + E +++KE + E
Sbjct: 131 KGRERERDRGRERERDRDREKER-ERQTEKDRDGQRETETERERDREREKQKERETERDR 189
Query: 602 EEEEEPEQK 610
+ + + E++
Sbjct: 190 DRQRDTEKE 198
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 180 bits (457), Expect = 4e-45
Identities = 87/219 (39%), Positives = 147/219 (67%), Gaps = 10/219 (4%)
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341
SK H E E +++ER+ R+R +E + E ER+R+R+RER RE++++R
Sbjct: 3 SKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDR 62
Query: 342 ERERERDRDRDRTKERDRDRDRER--DRDRDRERSSDRNKDRSRSREKSRDRERERERER 399
ERE++ DR+ +R +ER+RDRDR+R +R+RD+ER +DR+ + R R+K ++RE ER R+R
Sbjct: 63 EREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122
Query: 400 EREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQE 459
ERE+++E RER+ +RE +RERER+ E++++ RE ED + R+ ERK +E
Sbjct: 123 EREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERK--------RE 174
Query: 460 RLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
R + E +ER++ + E+E +RE +R+R+ +E++R ++
Sbjct: 175 RERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 159 bits (401), Expect = 1e-38
Identities = 87/204 (42%), Positives = 129/204 (63%), Gaps = 29/204 (14%)
Query: 260 TKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERE 319
T + ++ + ++R RE + RD K+ + E E++RQ + RER+R+RERE
Sbjct: 10 THTETETMDRQRERR----RETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65
Query: 320 RE---------RREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRD 370
++ RER+R+R+RE ERE++KERE +R + DR+R K+++R+ +R RDR+R+
Sbjct: 66 KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125
Query: 371 ------RERSSDRNKDRSRSREKSRDRE---------RERERERERERERERERE-RERE 414
RER +DR DR R R+ R+RE R RERERER+RERER+RE +ERE
Sbjct: 126 KQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERE 185
Query: 415 REREREREREREKDKKRDREEDEE 438
R + ERER+RE D+KRDR+ + E
Sbjct: 186 RHTDMERERQRETDRKRDRQRESE 209
Score = 151 bits (382), Expect = 2e-36
Identities = 100/279 (35%), Positives = 151/279 (54%), Gaps = 69/279 (24%)
Query: 308 ERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR 367
E + R E E +R+RER RE +RE+++ +E + E DR +R ++RDR+R+RERDR
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTE-DRHSERDRQRDRERNRERDR 60
Query: 368 DRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER--ERERERERERER 425
DR+RE+ +DR +R R +RER+R+R+RE ERER++ERE +R E +RER++++ER
Sbjct: 61 DREREKQTDREGERQR------ERERDRDRQRETERERDKERETDRHTETDRERQKQKER 114
Query: 426 EKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEER 485
E ++ RDRE + ++KE RER+ RE ++E ER+ ER
Sbjct: 115 EMERVRDRERE--------------KQKEMG----------RERQTDRETDRERERQAER 150
Query: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE 545
RE +E K + R R+RE+E RKRE+E E
Sbjct: 151 ERETGRERK-----------------------TEDRHRERERE-------RKRERERKRE 180
Query: 546 IRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE 584
++R E H D + E QR E +R+R Q + E E +
Sbjct: 181 TKER---ERHTDMERERQR---ETDRKRDRQRESERERD 213
Score = 134 bits (338), Expect = 3e-31
Identities = 86/262 (32%), Positives = 135/262 (51%), Gaps = 55/262 (20%)
Query: 340 ERERERERDRDRDRTKERDRDRDRERDRDRDRERSS---DRNKDRSRSREKSRDRERERE 396
E + E T +R R+R RE DR+RDR + S DR+ +R R R++ R+RER+R+
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRD 61
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
RERE++ +RE ER+RERER+R+R+RE ERE+DK+R+ + E ER+K
Sbjct: 62 REREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQK----------- 110
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
+K RE E+ +RE E+++EM +E + D + DR+
Sbjct: 111 -------------QKEREMERVRDREREKQKEMGRERQT------DRETDRE-------- 143
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
R R E+E E R+RK E E R+R E +R + ER R
Sbjct: 144 ----RERQAERERETG-RERKTEDRHRERERER---------KRERERKRETKERERHTD 189
Query: 577 IKQEPESEEEEEEKQEKEEKRE 598
+++E + E + + +++E +RE
Sbjct: 190 MERERQRETDRKRDRQRESERE 211
Score = 67.8 bits (164), Expect = 4e-11
Identities = 52/217 (23%), Positives = 94/217 (43%), Gaps = 55/217 (25%)
Query: 394 EREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREK 453
E + E +R+RER RE +RER+R K+ K + E D +R ER
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERD--RQRDRERN---- 55
Query: 454 EAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY 513
RER + RE EK+ +RE ER+RE
Sbjct: 56 -------------RERDRDREREKQTDREGERQRE------------------------- 77
Query: 514 RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRR 573
R+R+++ + E +R+R+KE + E + E++R+ ++ ER +
Sbjct: 78 ---------RERDRDRQR-ETERERDKERETDRHTETDRERQKQKEREMERV-RDREREK 126
Query: 574 QPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Q ++ +E +++ E + ++E++ +RE E + E +
Sbjct: 127 QKEMGRERQTDRETDRERERQAERERETGRERKTEDR 163
Score = 40.4 bits (93), Expect = 0.007
Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 518 LQKRLRDREKEMEADERDRKRE-KEELEEIRQRLLAEGHPDPDAELQRM-EQEAERRRQP 575
++ + R E + DR+RE + E + R R D +E R ++E R R
Sbjct: 1 MESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR 60
Query: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
++E +++ E E ++E+E R+ E E E +++
Sbjct: 61 DREREKQTDREGERQRERERDRDRQRETERERDKE 95
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 180 bits (456), Expect = 6e-45
Identities = 87/193 (45%), Positives = 137/193 (70%), Gaps = 7/193 (3%)
Query: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER-------RERERER 329
+ R+ + R+T + E E+ + + +E + ER R R+R+R RER +ERER++
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 330 EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSR 389
ER+R+R++E+E ERE ER R+R R +ER R DRERD+DRDRER + +++R R+R+ R
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120
Query: 390 DREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERK 449
+R+++ ERER+RERER+R+RERER+R+RER+RE +RE+ + +REE +++ + RK ERK
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERK 180
Query: 450 LREKEAAYQERLK 462
++KE +E K
Sbjct: 181 EKKKEEKRREDKK 193
Score = 176 bits (445), Expect = 1e-43
Identities = 90/208 (43%), Positives = 143/208 (68%), Gaps = 18/208 (8%)
Query: 285 RDTHKKLEEEKGKKEKERQEIEKER-RERERERERERERREREREREREREREKEKERER 343
R +K E ++GK E E+ER R+RERE + ERE R R+R+R RER+R+ ++E+ER
Sbjct: 3 RQRERKRETDRGK------ETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKER 56
Query: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
ER+++RDR R +ER+ +R+ ER R+R R+R R DR R +++ R+R+RE +R RER R
Sbjct: 57 ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNR 116
Query: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
+ RER+++ ERER+RERER+R+++++R R+ ER++ + R++ A +ER K
Sbjct: 117 KGGRERDKQTERERDRERERQRQRERERQRQR------ERKRETDRERQRWAEREERKK- 169
Query: 464 WEIRERKKTREYEKEAEREEERRREMAK 491
ERKK R+ E++ +++EE+RRE K
Sbjct: 170 ----ERKKERKKERKEKKKEEKRREDKK 193
Score = 173 bits (438), Expect = 7e-43
Identities = 82/184 (44%), Positives = 130/184 (70%), Gaps = 3/184 (1%)
Query: 279 REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER---RERERERERERER 335
+E + RD ++ E + ++ + RQ R+R+ +RE+ERER R+R+R+RERE ER
Sbjct: 15 KETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETER 74
Query: 336 EKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
E E++RER+R+R+R R +ERD+DRDRER R+ DR R +R R R ++ R+R+RER
Sbjct: 75 ETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRER 134
Query: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
ER+R+RERER+R+RER+RE +RER+R ERE+ KK ++E +++ E++K E++ +K+
Sbjct: 135 ERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKR 194
Query: 456 AYQE 459
+ E
Sbjct: 195 KWGE 198
Score = 172 bits (435), Expect = 2e-42
Identities = 88/194 (45%), Positives = 138/194 (71%), Gaps = 7/194 (3%)
Query: 311 ERERERERERER-REREREREREREREKEKERE-RERERDRDRDRTKERDRDRDRERDRD 368
ER+RER+RE +R +E ERER+R+RERE + ERE R R+RDR R+R ++ DR+++RER ++
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 369 RDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERE--RE 426
RDR+R +R +R R++ R R+RER+R+ +RER+++R+RER+RE +R RER R+ RE
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 427 KDKKRDREEDEEDAYER---RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
+DK+ +RE D E +R R+ +R+ K +ER + E ERKK R+ E++ ER+E
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181
Query: 484 ERRREMAKEAKRLK 497
+++ E +E K+ K
Sbjct: 182 KKKEEKRREDKKRK 195
Score = 158 bits (400), Expect = 2e-38
Identities = 88/229 (38%), Positives = 146/229 (63%), Gaps = 31/229 (13%)
Query: 326 EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385
ER+RER+RE ++ KE ERER+R R+R+ ER+ +R R+RDR R+R+R +DR K+R
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERE-NRHRQRDRHRERDRQTDREKER---- 56
Query: 386 EKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRK 445
ER++ER+R+R+RERE ERE ER+RER+R+RER+R+ D++RD++ D E +R+
Sbjct: 57 ------ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE---RKRE 107
Query: 446 LERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDD 505
+R +ER K E RER + RE +++ ERE +R+RE +E R ++
Sbjct: 108 TDRNRERNRKGGRERDKQTE-RERDRERERQRQRERERQRQRERKRETDRERQ------- 159
Query: 506 DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEG 554
R + ++R ++R+KE + + +++K+E++ E+ ++R EG
Sbjct: 160 --------RWAEREERKKERKKERKKERKEKKKEEKRRED-KKRKWGEG 199
Score = 143 bits (360), Expect = 8e-34
Identities = 75/173 (43%), Positives = 123/173 (71%), Gaps = 5/173 (2%)
Query: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK-KEKERQEIEKERRERERERERE 319
+E N E E R R + R T ++ E E+ K ++++RQ + RE ER+RER+
Sbjct: 25 RERENQTERENRHRQR-DRHRERDRQTDREKERERQKERDRQRQRERETERETERQRERQ 83
Query: 320 RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
R+ RER+R+ +RER++++++ER+RE +R+R+R+R R+RD+ ER+RDR+RER R +
Sbjct: 84 RQ-RERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRER 142
Query: 380 DRSRSREKSRDRERERERERERERERERERERERERER-EREREREREKDKKR 431
+R R RE+ R+ +RER+R ERE ER++ER++ER++ER E+++E +R +DKKR
Sbjct: 143 ERQRQRERKRETDRERQRWAERE-ERKKERKKERKKERKEKKKEEKRREDKKR 194
Score = 121 bits (303), Expect = 3e-27
Identities = 72/216 (33%), Positives = 125/216 (57%), Gaps = 28/216 (12%)
Query: 389 RDRERERERERERERERERERERERERERERE-REREREKDKKRDREEDEEDAYERRKLE 447
R RER+RE +R +E ERER+R+RERE + ERE R R+R++ ++RDR+ D E ER+K
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK-- 60
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
ER + R+ E+E ERE ER+RE ++ +R ++ + D DR
Sbjct: 61 --------------------ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDR 100
Query: 508 DDPKYYRGSALQKRL----RDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQ 563
D + ++R R+R+K+ E ERDR+RE++ E ++ E + D E Q
Sbjct: 101 DRERKRETDRNRERNRKGGRERDKQTER-ERDRERERQRQRERERQRQRERKRETDRERQ 159
Query: 564 RMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
R + ER+++ + +++ E +E+++E++ +E+K+ +
Sbjct: 160 RWAEREERKKERKKERKKERKEKKKEEKRREDKKRK 195
Score = 95.5 bits (236), Expect = 2e-19
Identities = 50/141 (35%), Positives = 92/141 (65%), Gaps = 12/141 (8%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER-RERERERERERER---- 322
+ E D++ RE + + ++ + ++ +K + +E +K+R RER+RE +R RER
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKG 118
Query: 323 ---REREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
R+++ ERER+RERE++++RERER+R R+R R +R+R R ER+ +R +ER +R K
Sbjct: 119 GRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAERE-ERKKERKKERKK 177
Query: 380 DRSRSREKSRDRERERERERE 400
+R +EK ++ +R +++R+
Sbjct: 178 ER---KEKKKEEKRREDKKRK 195
Score = 84.0 bits (206), Expect = 5e-16
Identities = 56/185 (30%), Positives = 104/185 (56%), Gaps = 28/185 (15%)
Query: 216 REYSSELNAPSQESDSH-------PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIE 268
RE +E ++ D H R+K++E++++ R+ ++ E
Sbjct: 27 RENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQ-------------RQRERETE 73
Query: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRE---RERERERERER-RE 324
E +++ R+ + R T ++ ++++ ++ K + +ER RER+++ ERER RE
Sbjct: 74 RETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRE 133
Query: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
RER+R+RERER +++RER+RE DR+R R ER+ +R +ER ++R +ER ++ K+ R
Sbjct: 134 RERQRQRERER--QRQRERKRETDRERQRWAERE-ERKKERKKERKKER-KEKKKEEKRR 189
Query: 385 REKSR 389
+K R
Sbjct: 190 EDKKR 194
Score = 50.1 bits (118), Expect = 9e-06
Identities = 31/98 (31%), Positives = 56/98 (57%), Gaps = 7/98 (7%)
Query: 519 QKRLRDREKEMEADERDRKREKEELEEIRQR-LLAEGHPDPDAELQR-----MEQEAERR 572
+KR DR KE E ERDR+RE+E E R + H + D + R ++E +R+
Sbjct: 7 RKRETDRGKETER-ERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQ 65
Query: 573 RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
RQ + + E E+E + E ++++E KR+ E +++ +++
Sbjct: 66 RQRERETERETERQRERQRQRERKRQTDRERDKDRDRE 103
Score = 39.3 bits (90), Expect = 0.015
Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 8/83 (9%)
Query: 533 ERDRKREKE-----ELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEE 587
+R+RKRE + E E RQR E + E + +++ R R Q +E E E ++
Sbjct: 4 QRERKRETDRGKETERERDRQR---ERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 588 EEKQEKEEKREEPMEEEEEPEQK 610
E ++++ +RE E E + E++
Sbjct: 61 ERDRQRQRERETERETERQRERQ 83
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 164 bits (414), Expect = 4e-40
Identities = 143/579 (24%), Positives = 255/579 (44%), Gaps = 96/579 (16%)
Query: 35 PGTPMIPVPMSIMAPAP-TVLVPTVSMVGKHLGARKDHPGLKAKENDE-----NCGPTT- 87
PG ++P+P P P T L ++S +G A D E + N P+
Sbjct: 122 PGAGLLPIP----TPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKI 177
Query: 88 -----TVFVGNISEKAS--DMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPEST 140
TV+VGN++ + + D L+ + + G V + R+ G + F F E+ + S
Sbjct: 178 DEIRRTVYVGNLNSQTTTADQLL-EFFKQVGEV-KFVRMAGDETQPTRFAFVEFADQNSV 235
Query: 141 LRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEET 200
RAL + + G++ L + ++N +P +T EE
Sbjct: 236 PRALAF-NGVMFGDRPLKIN----------------HSNNAIVKPPEMTPQAAAKELEEV 278
Query: 201 KRRDQMIKGAIEVLIREYSSELNA-PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLI 259
+R + + I I S + N S SH R K + + RR
Sbjct: 279 MKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR------------ 326
Query: 260 TKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERE 319
+ + K S S+ R ++ + KK + +E R + R R
Sbjct: 327 --------KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE-----RRKSRSRSHS 373
Query: 320 RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
R++R+ RE+ +E+ER KEK+RE+ERER+++R++ KER +++DR+++R++D
Sbjct: 374 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD--------- 424
Query: 380 DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
REK ++++RERERE+E E++R++E+E+E+++E+ERE++R +E D+KR +++
Sbjct: 425 -----REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
Query: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
R+ R + R R + ++ ++++ R R K+ KR KE
Sbjct: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE- 538
Query: 500 LEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH---P 556
R ++R R+R M DR KE+LE+ L + H P
Sbjct: 539 --------------RDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEP 583
Query: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595
D + +++A R + +I+ + EE K E
Sbjct: 584 DSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622
Score = 152 bits (383), Expect = 2e-36
Identities = 88/314 (28%), Positives = 166/314 (52%), Gaps = 10/314 (3%)
Query: 291 LEEEKGKK-EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
+E E GK E++ R + R + RR+R + + R R + + R+++R R +
Sbjct: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
Query: 350 D--RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
+ R+K R+R + R R RD+ R R K + + R K +DRE+ERERE+ERE+E+ER
Sbjct: 353 SPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKEKERVKEKDREKEREREKEREKEKER 411
Query: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
+ ++R++ERE++RE+++EKD++R+RE++ E ++ K + + +EKE +E+ ++ EI
Sbjct: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---REKDRSKEID 468
Query: 468 ERKKTREYEKEAER--EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
E++K + + R RR + +R + R R S+ R R
Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
Query: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
K+ + E++R E E R + + D D + +++E+ + ++ + +EP+S
Sbjct: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSV 587
Query: 586 EEEEKQEKEEKREE 599
+E + + EE
Sbjct: 588 SKEVDDKDAPRTEE 601
Score = 126 bits (316), Expect = 1e-28
Identities = 85/310 (27%), Positives = 143/310 (46%), Gaps = 39/310 (12%)
Query: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
EE K+ +E Q E E + ER + R R R + R K R R R
Sbjct: 276 EEVMKRVREAQSFISAAIEPESGKSNER-KGGRSRSHTRSKSRSSSKSHSR-----RKRS 329
Query: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE---RERERERER 409
++K R R +R R R +DR RS +K RS+SRE+ + R R R++ RE+ +E+ER
Sbjct: 330 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER 389
Query: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
+E++RE+ERERE+EREK+K+R + +D + +ER
Sbjct: 390 VKEKDREKEREREKEREKEKERGKNKDRD----------------------------KER 421
Query: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM 529
+K RE K+ E++ ER RE E R KE ++ D +++ K +KR +D++
Sbjct: 422 EKDRE--KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
Query: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
+ R R+R + + +++++ R P+ + + + + E+E
Sbjct: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539
Query: 590 KQEKEEKREE 599
E + E
Sbjct: 540 DHISERRERE 549
Score = 108 bits (270), Expect = 2e-23
Identities = 79/309 (25%), Positives = 140/309 (45%), Gaps = 45/309 (14%)
Query: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
+E E +R RE + E + + ++ R R R + R +S R K RS+S
Sbjct: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-RSQS 331
Query: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
+ +SR R R R+++R R + ++R + RER + R R +DK++D E
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE--------- 382
Query: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
K++EKE ++E+ + +E E+E ERE+E+ R K R KE +D +
Sbjct: 383 ----KIKEKE----------RVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDRE 426
Query: 505 DDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREK-EELEEIRQRLLAEGHPDPDAEL 562
D++ + ++ RD+EKE E D E++R++++ +E++E R++ P
Sbjct: 427 KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 486
Query: 563 QR----MEQEAERRRQPQIKQEPE-------------SEEEEEEKQEKEEKREEPMEEEE 605
R +E RRR + P S +K +K EK + + E
Sbjct: 487 SRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546
Query: 606 EPEQKPCLK 614
E E+ ++
Sbjct: 547 ERERSTSMR 555
Score = 85.1 bits (209), Expect = 2e-16
Identities = 92/416 (22%), Positives = 168/416 (40%), Gaps = 105/416 (25%)
Query: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
KE E +R R+ + + + + +R R RS R+K RS S+ SR R+
Sbjct: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-----RK 327
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
R + + R R R R R+++R R + +++ K R+R + ++ R K
Sbjct: 328 RSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK----------- 376
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
RK TRE KE ER +E+ RE +E ++ +E ++ ++D K
Sbjct: 377 ------------RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK----- 419
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
+R +DREK+ E+DR+RE+E
Sbjct: 420 ---EREKDREKDK---EKDRERERE----------------------------------- 438
Query: 577 IKQEPESEEEEEEKQ-EKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATP 635
K+ + ++E+EK+ +KE++RE+ +E + ++K K P S S S S +
Sbjct: 439 -KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS--- 494
Query: 636 NTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVF 695
E + + P+ ++K +S SP P S +K
Sbjct: 495 --------------RERRRRRSRSSSRSPRTSKTIKRKSSRSP-SPRSRNKK-------- 531
Query: 696 NKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPE 751
+K +++ D + +R+ + + ++ E+ K+ SL EK +P+
Sbjct: 532 DKKREKERDHISERRE---RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 164 bits (414), Expect = 4e-40
Identities = 143/579 (24%), Positives = 255/579 (44%), Gaps = 96/579 (16%)
Query: 35 PGTPMIPVPMSIMAPAP-TVLVPTVSMVGKHLGARKDHPGLKAKENDE-----NCGPTT- 87
PG ++P+P P P T L ++S +G A D E + N P+
Sbjct: 6 PGAGLLPIP----TPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKI 61
Query: 88 -----TVFVGNISEKAS--DMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPEST 140
TV+VGN++ + + D L+ + + G V + R+ G + F F E+ + S
Sbjct: 62 DEIRRTVYVGNLNSQTTTADQLL-EFFKQVGEV-KFVRMAGDETQPTRFAFVEFADQNSV 119
Query: 141 LRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEET 200
RAL + + G++ L + ++N +P +T EE
Sbjct: 120 PRALAF-NGVMFGDRPLKIN----------------HSNNAIVKPPEMTPQAAAKELEEV 162
Query: 201 KRRDQMIKGAIEVLIREYSSELNA-PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLI 259
+R + + I I S + N S SH R K + + RR
Sbjct: 163 MKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR------------ 210
Query: 260 TKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERE 319
+ + K S S+ R ++ + KK + +E R + R R
Sbjct: 211 --------KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE-----RRKSRSRSHS 257
Query: 320 RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
R++R+ RE+ +E+ER KEK+RE+ERER+++R++ KER +++DR+++R++D
Sbjct: 258 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD--------- 308
Query: 380 DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
REK ++++RERERE+E E++R++E+E+E+++E+ERE++R +E D+KR +++
Sbjct: 309 -----REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 363
Query: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
R+ R + R R + ++ ++++ R R K+ KR KE
Sbjct: 364 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE- 422
Query: 500 LEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH---P 556
R ++R R+R M DR KE+LE+ L + H P
Sbjct: 423 --------------RDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEP 467
Query: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595
D + +++A R + +I+ + EE K E
Sbjct: 468 DSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 506
Score = 152 bits (383), Expect = 2e-36
Identities = 88/314 (28%), Positives = 166/314 (52%), Gaps = 10/314 (3%)
Query: 291 LEEEKGKK-EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
+E E GK E++ R + R + RR+R + + R R + + R+++R R +
Sbjct: 177 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 236
Query: 350 D--RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
+ R+K R+R + R R RD+ R R K + + R K +DRE+ERERE+ERE+E+ER
Sbjct: 237 SPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKEKERVKEKDREKEREREKEREKEKER 295
Query: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
+ ++R++ERE++RE+++EKD++R+RE++ E ++ K + + +EKE +E+ ++ EI
Sbjct: 296 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---REKDRSKEID 352
Query: 468 ERKKTREYEKEAER--EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
E++K + + R RR + +R + R R S+ R R
Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412
Query: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
K+ + E++R E E R + + D D + +++E+ + ++ + +EP+S
Sbjct: 413 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSV 471
Query: 586 EEEEKQEKEEKREE 599
+E + + EE
Sbjct: 472 SKEVDDKDAPRTEE 485
Score = 126 bits (316), Expect = 1e-28
Identities = 85/310 (27%), Positives = 143/310 (46%), Gaps = 39/310 (12%)
Query: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
EE K+ +E Q E E + ER + R R R + R K R R R
Sbjct: 160 EEVMKRVREAQSFISAAIEPESGKSNER-KGGRSRSHTRSKSRSSSKSHSR-----RKRS 213
Query: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE---RERERERER 409
++K R R +R R R +DR RS +K RS+SRE+ + R R R++ RE+ +E+ER
Sbjct: 214 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER 273
Query: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469
+E++RE+ERERE+EREK+K+R + +D + +ER
Sbjct: 274 VKEKDREKEREREKEREKEKERGKNKDRD----------------------------KER 305
Query: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM 529
+K RE K+ E++ ER RE E R KE ++ D +++ K +KR +D++
Sbjct: 306 EKDRE--KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 363
Query: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
+ R R+R + + +++++ R P+ + + + + E+E
Sbjct: 364 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 423
Query: 590 KQEKEEKREE 599
E + E
Sbjct: 424 DHISERRERE 433
Score = 108 bits (270), Expect = 2e-23
Identities = 79/309 (25%), Positives = 140/309 (45%), Gaps = 45/309 (14%)
Query: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
+E E +R RE + E + + ++ R R R + R +S R K RS+S
Sbjct: 157 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-RSQS 215
Query: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
+ +SR R R R+++R R + ++R + RER + R R +DK++D E
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE--------- 266
Query: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
K++EKE ++E+ + +E E+E ERE+E+ R K R KE +D +
Sbjct: 267 ----KIKEKE----------RVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDRE 310
Query: 505 DDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREK-EELEEIRQRLLAEGHPDPDAEL 562
D++ + ++ RD+EKE E D E++R++++ +E++E R++ P
Sbjct: 311 KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 370
Query: 563 QR----MEQEAERRRQPQIKQEPE-------------SEEEEEEKQEKEEKREEPMEEEE 605
R +E RRR + P S +K +K EK + + E
Sbjct: 371 SRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 430
Query: 606 EPEQKPCLK 614
E E+ ++
Sbjct: 431 ERERSTSMR 439
Score = 85.1 bits (209), Expect = 2e-16
Identities = 92/416 (22%), Positives = 168/416 (40%), Gaps = 105/416 (25%)
Query: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
KE E +R R+ + + + + +R R RS R+K RS S+ SR R+
Sbjct: 157 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-----RK 211
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
R + + R R R R R+++R R + +++ K R+R + ++ R K
Sbjct: 212 RSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK----------- 260
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
RK TRE KE ER +E+ RE +E ++ +E ++ ++D K
Sbjct: 261 ------------RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK----- 303
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
+R +DREK+ E+DR+RE+E
Sbjct: 304 ---EREKDREKDK---EKDRERERE----------------------------------- 322
Query: 577 IKQEPESEEEEEEKQ-EKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATP 635
K+ + ++E+EK+ +KE++RE+ +E + ++K K P S S S S +
Sbjct: 323 -KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS--- 378
Query: 636 NTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVF 695
E + + P+ ++K +S SP P S +K
Sbjct: 379 --------------RERRRRRSRSSSRSPRTSKTIKRKSSRSP-SPRSRNKK-------- 415
Query: 696 NKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPE 751
+K +++ D + +R+ + + ++ E+ K+ SL EK +P+
Sbjct: 416 DKKREKERDHISERRE---RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 468
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 160 bits (406), Expect = 4e-39
Identities = 88/198 (44%), Positives = 136/198 (68%), Gaps = 8/198 (4%)
Query: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKER-RERERERERERER-RERERERERERE 334
I RE + R+ ++ + K + ++ +EIEK+R R+R+R+RER+R R R+R+RER +R+
Sbjct: 56 IIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRD 115
Query: 335 REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSR---SREKSRDR 391
RE E ER+ ERER RDR R K+R+R R RE D+DRE +++++DR R E+ RDR
Sbjct: 116 RETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDR 175
Query: 392 ERERERERERERERERERERERE-REREREREREREKDKKRDRE--EDEEDAYERRKLER 448
ERER+++RE R+R+RER+RE+E RER+R+R++EREKD+ R+RE D + +R +
Sbjct: 176 ERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQRE 235
Query: 449 KLREKEAAYQERLKNWEI 466
K R+++ A WE+
Sbjct: 236 KDRDRQKAIDCVPGRWEV 253
Score = 160 bits (406), Expect = 4e-39
Identities = 87/191 (45%), Positives = 137/191 (71%), Gaps = 19/191 (9%)
Query: 310 RERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR--ERDR 367
RERER+RERER+R+ R +ER RE++RE EK+R+R+R+RDR+R R ++RDR R+R +RDR
Sbjct: 58 RERERQRERERQRK-RAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDR 116
Query: 368 DRDRERSSDRNKDRSRSREKSRDRERERE----RERERERERERERERE-------RERE 416
+ + ER +R + R R REK R+R+R+RE ++RE E E++R+RERE R+RE
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRE 176
Query: 417 REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE 476
RER+++RE +D+ R+R+ ++ED ER + +K REK+ Y+ER R+R K R+ E
Sbjct: 177 RERQKQRETRRDRDRERQREKEDR-ERDRDRQKEREKD-RYRERETG---RDRDKERDRE 231
Query: 477 KEAEREEERRR 487
++ E++ +R++
Sbjct: 232 RQREKDRDRQK 242
Score = 157 bits (396), Expect = 5e-38
Identities = 81/191 (42%), Positives = 128/191 (67%), Gaps = 8/191 (4%)
Query: 323 REREREREREREREKEKERERERER--DRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
RERER+RERER+R++ KER RE++R ++DRDR ++RDR+R R RDRDR RER DR+
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRD-- 115
Query: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
RE +R+ ERER+R+R+RE++RER+R+RE +++RE E EKD+ R+RE E +
Sbjct: 116 ----RETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETER 171
Query: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
Y R+ ER+ + + ++R + E +R++ R+ +KE E++ R RE ++ + ++
Sbjct: 172 YRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRE 231
Query: 501 EDYDDDRDDPK 511
+ DRD K
Sbjct: 232 RQREKDRDRQK 242
Score = 154 bits (390), Expect = 3e-37
Identities = 81/190 (42%), Positives = 133/190 (70%), Gaps = 12/190 (6%)
Query: 266 AIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER-RE 324
AI E +++ R+ + ++ H++ + E +K+++RQ R+R R+R+R+RER +
Sbjct: 55 AIIRERERQRERERQRKRAKERHREKDREI-EKDRDRQRKRDRERQRWRDRDRKRERWGD 113
Query: 325 REREREREREREKEKERERERERDRDRDRTKE----RDRDRDRERDRDRDR-----ERSS 375
R+RE E ER+ E+E++R+R+RE+DR+R R +E +DR+ + E+DRDR+R ER
Sbjct: 114 RDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYR 173
Query: 376 DRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREE 435
DR ++R + RE RDR+RER+RE+E +RER+R+R++ERE++R RERE R++DK+RDRE
Sbjct: 174 DRERERQKQRETRRDRDRERQREKE-DRERDRDRQKEREKDRYRERETGRDRDKERDRER 232
Query: 436 DEEDAYERRK 445
E +R+K
Sbjct: 233 QREKDRDRQK 242
Score = 141 bits (355), Expect = 3e-33
Identities = 82/203 (40%), Positives = 127/203 (62%), Gaps = 23/203 (11%)
Query: 339 KERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE 398
+ERER+RER+R R R KER R++DRE ++DRDR+R +DR R R + RDR+RER +
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRK----RDRERQRWRDRDRKRERWGD 113
Query: 399 REREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ 458
R+RE E ER+ ERER+R+R+RE++RER++ ++ ++D E E+ + RE+E
Sbjct: 114 RDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEK----DRDREREMGET 169
Query: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
ER ++ E RER+K RE ++ +RE +R + ED + DRD K
Sbjct: 170 ERYRDRE-RERQKQRETRRDRDRERQREK-------------EDRERDRDRQKEREKDRY 215
Query: 519 QKRLRDREKEMEADERDRKREKE 541
++R R+++ E D R+R+REK+
Sbjct: 216 RERETGRDRDKERD-RERQREKD 237
Score = 116 bits (291), Expect = 8e-26
Identities = 72/222 (32%), Positives = 131/222 (59%), Gaps = 34/222 (15%)
Query: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
R R R++ R+R+R+R +ER RE++RE E++R+R+R+R+RER+R R++D+KR+R D +
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRD-- 115
Query: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
RE E QE ER++ R+ ++E +RE +R+RE+ + R E
Sbjct: 116 ----------RETETERQE--------ERERQRDRKREKDRERQRQREIGIDKDREIETE 157
Query: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
+D D +R+ + R + R R+R+K+ E RDR RE++ +E R+R D
Sbjct: 158 KDRDREREMGETER---YRDRERERQKQRET-RRDRDRERQREKEDRER---------DR 204
Query: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPME 602
+ Q+ E+E +R R+ + ++ + E + E ++EK+ R++ ++
Sbjct: 205 DRQK-EREKDRYRERETGRDRDKERDRERQREKDRDRQKAID 245
Score = 115 bits (287), Expect = 2e-25
Identities = 72/217 (33%), Positives = 123/217 (56%), Gaps = 32/217 (14%)
Query: 399 REREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ 458
RERER+RERER+R+R +ER RE++RE EKD+ R R+ D ER++ + R++E
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDR----ERQRWRDRDRKRE---- 109
Query: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
W R+R+ E ++E ER+ +R+RE +E +R +E D D + + K
Sbjct: 110 ----RWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKD------ 159
Query: 519 QKRLRDREKEMEADE--RDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
RDRE+EM E RDR+RE+++ E R+ D D E QR +++ ER R Q
Sbjct: 160 ----RDREREMGETERYRDRERERQKQRETRR--------DRDRERQREKEDRERDRDRQ 207
Query: 577 IKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCL 613
++E + E E ++++++R+ + E++ +++ +
Sbjct: 208 KEREKDRYRERETGRDRDKERDRERQREKDRDRQKAI 244
Score = 104 bits (259), Expect = 4e-22
Identities = 67/171 (39%), Positives = 98/171 (57%), Gaps = 44/171 (25%)
Query: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLE---------EEKGKKEKERQEIEKERRE 311
+E IE + D++ RE ++RD +K E E + ++E+ERQ K ++
Sbjct: 78 REKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKD 137
Query: 312 RERERERE----------------RER----------REREREREREREREKEKERERER 345
RER+R+RE RER RERER+++RE R++++ER+RE+
Sbjct: 138 RERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREK 197
Query: 346 E-RDRDRDRTKERDRDRDRERD--RDRDRERSSDRNKDRSRSREKSRDRER 393
E R+RDRDR KER++DR RER+ RDRD+ER DR R REK RDR++
Sbjct: 198 EDRERDRDRQKEREKDRYRERETGRDRDKER------DRERQREKDRDRQK 242
Score = 94.4 bits (233), Expect = 4e-19
Identities = 54/149 (36%), Positives = 90/149 (60%), Gaps = 21/149 (14%)
Query: 221 ELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK-RDLISR 279
E QE R +K+EK + R+ + I K+ IE E+D+ R+
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIG-------IDKD--REIETEKDRDREREMG 167
Query: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEK 339
E ++RD +E+ERQ+ + RR+R+RER+RE+E RER+R+R++ERE+++ +
Sbjct: 168 ETERYRD-----------RERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYR 216
Query: 340 ERERERERDRDRDRTKERDRDRDRERDRD 368
ERE R+RD++RDR ++R++DRDR++ D
Sbjct: 217 ERETGRDRDKERDRERQREKDRDRQKAID 245
Score = 66.2 bits (160), Expect = 1e-10
Identities = 47/160 (29%), Positives = 85/160 (53%), Gaps = 20/160 (12%)
Query: 466 IRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
IRER++ RE E++ +R +ER RE +E ++ ++ DR+ ++ ++R DR
Sbjct: 57 IRERERQRERERQRKRAKERHREKDREIEKDRD--RQRKRDRERQRWRDRDRKRERWGDR 114
Query: 526 EKEMEAD-------ERDRKREKEELEEIRQR---------LLAEGHPDPDAELQRMEQEA 569
++E E + +RDRKREK+ E RQR + E D + E+ E+
Sbjct: 115 DRETETERQEERERQRDRKREKDR-ERQRQREIGIDKDREIETEKDRDREREMGETERYR 173
Query: 570 ERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
+R R+ Q ++E + + E ++EKE+ RE + ++E E+
Sbjct: 174 DRERERQKQRETRRDRDRERQREKED-RERDRDRQKEREK 212
Score = 44.7 bits (104), Expect = 4e-04
Identities = 37/113 (32%), Positives = 60/113 (53%), Gaps = 16/113 (14%)
Query: 505 DDRDDPKYYRGSALQKRL-RDREKEMEADERDRKREKE-------ELEEIRQRLLAEGHP 556
+DRD RGS + + R+RE++ E ER RKR KE E+E+ R R
Sbjct: 40 EDRD-VLILRGSRVAPAIIRERERQRER-ERQRKRAKERHREKDREIEKDRDR-----QR 92
Query: 557 DPDAELQR-MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
D E QR +++ +R R +E E+E +EE +++++ KRE+ E + + E
Sbjct: 93 KRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQRE 145
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 154 bits (390), Expect = 3e-37
Identities = 128/497 (25%), Positives = 250/497 (50%), Gaps = 67/497 (13%)
Query: 155 KKLLVKVDAKTKAQLDEWKAKKKASNGNAR----PETVTNDDEEALDEETKRRDQMIK-G 209
K LL +V T Q + W+ +++ + E + +E ++E K R+Q K
Sbjct: 221 KFLLPQVQTNT-LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279
Query: 210 AIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEM 269
E +RE EL QE + +KK +E++E + +++ E
Sbjct: 280 RQEKRLREQEKELR--EQEKELREQKKLREQEEQM---------------QEQEEKMWEQ 322
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERER-ERERERERRERERE 328
EE R+ +E +R + E+EK +E+E++ ++E R E+ ER RE+E R RE+E
Sbjct: 323 EEKMRE---QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379
Query: 329 R---EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385
+ + E+ +E+E+ RERE++ + + +E++ ++ + ++E + + +
Sbjct: 380 KMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 439
Query: 386 EKSRDRERERERERERERERERERERE-----------REREREREREREREKDKKRDRE 434
EK ++E+ +E+E + + E+ R++E +E+ RE+E + +++K RD+E
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 435 EDEEDAYERR-KLERKLREKEAAYQERLKNWE----IRERKKTREYEK------EAEREE 483
+ D ER + + +LREKE +E+ K W+ +RE KKT+E EK E REE
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559
Query: 484 ERRREMAKEAKRLKEFLEDYDD----------DRDDPKYYRGSALQ----KRLRDREKEM 529
ER RE K+ + +E + + ++ ++++ + + +Q K EK
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
E +E D+ +E+EE+ ++ + E + ++M ++ E+ R+ + K + + EE+ E
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ-EEKMRE 678
Query: 590 KQEKEEKREEPMEEEEE 606
++EK + +EE M E+EE
Sbjct: 679 QEEKMQGQEEKMREQEE 695
Score = 141 bits (355), Expect = 3e-33
Identities = 120/459 (26%), Positives = 232/459 (50%), Gaps = 46/459 (10%)
Query: 196 LDEETKRRDQM-IKGAIEVLIREYSSELNAPSQESDSHPRKKK-------KEKKEDIFRR 247
++E TK RD + ++ + E + NA QE +K KE K + R
Sbjct: 161 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERA 220
Query: 248 FPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK---------- 297
+ P + + +E E ++ I ++ K ++L E++GK
Sbjct: 221 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR 280
Query: 298 KEKERQEIEKERRERERERERERERRERERERERERER---EKEKERERERERDRDRDRT 354
+EK +E EKE RE+E+E +++ RE+E + + + E+ ++EK RE+E + R +R
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 340
Query: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERE 414
E+++ + + RD+E +R R +E+ R RE+E+ E+E E+ +E ER RERE
Sbjct: 341 WEQEKQMREQEQKMRDQEERMWEQDERLREKEE-RMREQEKMWEQE-EKMQEEERIRERE 398
Query: 415 REREREREREREKDKKRDREED-----EEDAYERRKL---ERKLREKEAAYQERLKNWEI 466
++ E E RE+++K ++E+ EE +++++L + KL E+E ++ K WE
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Query: 467 RERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDD------DRDDPKYYRGSAL-- 518
E+ + +E E++ R+ +M ++ ++ E E D D+++ + + L
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 519 -QKRLRDREKEMEADERDRKREKEELEEIR----QRLLAEGHPDPDAELQRMEQEAERRR 573
++R+R+++K + +E+ R+ +K + +E + + + E + E + E+E R
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 578
Query: 574 QPQIKQEPESE--EEEEEKQEKEEKREEPMEEEEEPEQK 610
Q + QE E + E+EE+ E+EEK +E E+ E E+K
Sbjct: 579 QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Score = 135 bits (340), Expect = 2e-31
Identities = 113/521 (21%), Positives = 257/521 (49%), Gaps = 52/521 (9%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV 213
++K L + + + + Q E + +KK + E + +E+ ++E K R+Q K +
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLRE---QEEQMQEQEEKMWEQEEKMREQEEKMWRQE 337
Query: 214 LIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK 273
R + E QE ++++ ++++ R KE+ + + +
Sbjct: 338 E-RLWEQEKQMREQEQKMRDQEERMWEQDERLRE-------------KEERMREQEKMWE 383
Query: 274 RDLISREISKFRDTHKKL--EEEKGKKEKERQEIEKERRERERERERERERRERERERER 331
++ +E + R+ KK+ EEE ++++E+ + ++E + E+E +++R ++E+
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443
Query: 332 EREREKEKERE-----------------------RERERDRDRDRTKERDRDRDRERDRD 368
E+E+ +E+E + +E+ R+++ ++ ++ RD+E+
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 369 RDRERSSDRNKDRSRSREKSRDRER-----ERERERERERERERERERERERERERERER 423
ER ++++ E+ R++++ E+ RE ++ +E+E++ + E+ RE ER R
Sbjct: 504 DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
EREK + + E E + ++ E K+RE+E E+ + + +E K + EK E+EE
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 484 ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL 543
E + + +E +E +++ + + ++++R++E++M+ E ++ RE+EE
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE-EKMREQEEK 682
Query: 544 EEIRQRLLAEGHPDPDAELQRMEQEAERR--RQPQIKQEPESEEEEEEKQEKEEKREEPM 601
+ ++ + E + ++M + E+ ++ ++ + E E+EE ++++EK +E +
Sbjct: 683 MQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERL 742
Query: 602 EEEEEPEQKPCLKPT--LRPISSAPSVSSASGNATPNTPGD 640
E EE +PCL P+ L +S SV A G A +P D
Sbjct: 743 PEHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEAGEGSPQD 783
Score = 115 bits (288), Expect = 2e-25
Identities = 113/459 (24%), Positives = 220/459 (47%), Gaps = 47/459 (10%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSE------LNAPSQE 228
KKK N PET T++ + ++E K Q E L RE ++ L E
Sbjct: 48 KKKKINNGTNPETTTSEGCHSPEDEKKASHQHQ----EALRREIEAQDHTIRILTCQKTE 103
Query: 229 SDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTH 288
++ +D R+F L +K+ + + R +S H
Sbjct: 104 LET-----ALYYSQDAARKFEDGNLGE----SKDLAGRLHHSWHFAGELQRALSAVSTWH 154
Query: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKE------KERE 342
KK + + KER + E E +++ +E+ R E EK KE +
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 343 RERERDR---DRDRTKERDRDRDRERDRDRDRERSSDRNKDRS-RSREKSRDRE-RERER 397
R+ ER + + +T + R+ + R++E+ + +++ R E+ R++E + RE+
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 274
Query: 398 ERERERERERERERERE-RERERE-REREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
E + R+ +R RE+E+E RE+E+E RE+++ ++++ +E EE +E+ + R+ EK
Sbjct: 275 EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMW 334
Query: 456 AYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRG 515
+ERL WE + K+ RE E++ +EER M ++ +RL+E E + +
Sbjct: 335 RQEERL--WE--QEKQMREQEQKMRDQEER---MWEQDERLREKEERMREQEKMWEQEEK 387
Query: 516 SALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPD------PDAELQRMEQEA 569
++R+R+REK+M +E + ++E++++ + + + + P+ + + EQE
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 447
Query: 570 ERRRQPQIKQEPESEEEEEEK--QEKEEKREEPMEEEEE 606
+ ++ +I ++ E ++EE QEK+ R+E M E+E+
Sbjct: 448 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Score = 60.5 bits (145), Expect = 6e-09
Identities = 59/238 (24%), Positives = 110/238 (46%), Gaps = 45/238 (18%)
Query: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
RN + +K +E+ R E E+ + +E +R+ ER + + +EE
Sbjct: 177 RNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM 236
Query: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
E R+ E+K+R++E K W R+ ++ RE E + +EE+ R ++ KRL
Sbjct: 237 WRQEEELREQEKKIRKQEE------KMW--RQEERLREQEGKMREQEEKMR---RQEKRL 285
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
+E +K LR++EKE+ R++K+ +E+ E+++++
Sbjct: 286 RE-------------------QEKELREQEKEL----REQKKLREQEEQMQEQ------- 315
Query: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLK 614
E + EQE + R Q + E E+EKQ +E++++ +EE EQ L+
Sbjct: 316 ----EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 369
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 149 bits (377), Expect = 8e-36
Identities = 120/472 (25%), Positives = 246/472 (52%), Gaps = 45/472 (9%)
Query: 156 KLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLI 215
K L V AK +AQ++E + + + + E + +E+ + E K ++Q E I
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEEKIQEQ------EEKI 323
Query: 216 REYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRD 275
RE ++ QE +++ +KE+ RR EM +K +
Sbjct: 324 REQEEKIR--EQEEKMRRQEEMMWEKEEKMRRQE------------------EMMWEKEE 363
Query: 276 LISREISKFRDTHKKL---EEEKGKKEKERQEIEKERRERERERERERERRERERERERE 332
+ R+ + +K+ EE +KE++ +E+E++ E+E+ RE+E +R+E E+ RE+E
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 333 REREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE 392
+ +E+E + R+ E+ R+++ K R++++ R ++ E+ R +++ + +E+ +E
Sbjct: 424 KRQEQEAKMWRQEEKIREQEE-KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 393 REREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR-KLERKLR 451
+ + E R++E+ E+E E+ R++E + R+++K R++EE + E+ + E K+R
Sbjct: 483 EKIHEQEEIWRQKEKMHEQE-EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIR 541
Query: 452 EKEAAYQERLKNWE---IRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD 508
E+E ++E K E I E +K +E E + R+EE+ RE ++ R +E + + ++ R
Sbjct: 542 EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 509 DPKYYRGSALQKRLRDREKEMEADERDRK-----REKEELEEIRQRLLAEGHP---DPDA 560
+ + +K EK E +E+ R+ RE+EE+ + ++ + E + +
Sbjct: 602 EQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661
Query: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPC 612
++Q E+ R+ + +QE + E+EE+ +E+EE +E E+ E E+K C
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 713
Score = 136 bits (342), Expect = 9e-32
Identities = 115/499 (23%), Positives = 253/499 (50%), Gaps = 37/499 (7%)
Query: 117 KRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKK 176
K +Q S KLQA + +E E R + + +++ + + + K + Q E K ++
Sbjct: 272 KELQSVSAKLQA----QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ--EEKIRE 325
Query: 177 KASNGNARPETVTNDDEEALDEETK--RRDQMIKGAIEVLIRE----YSSELNAPSQESD 230
+ + E + +E ++E K R+++M+ E + R+ + E QE
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 385
Query: 231 SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKK 290
+++K + E+ +E I E +++ + R+ K R+ +K
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 291 LEEEKGKKEKERQEIEKERRERERERERERERRERERERERERE---REKEKERERERER 347
+ E++ K ++ ++I ++ + RE E+ +E+E R+ E+ E+E R+KEK E+E +
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 348 DRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS-RDRERERERERERERERE 406
+ ++ ++ + ++ R++E R +++ R +E+ R+ E+ E+E+ E E+
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR 565
Query: 407 RERERERERERERERERE----REKDKKRDREEDEEDAYERR-KLERKLREKEAAYQERL 461
+E+E + R+ E+ RE+E R+++K R++EE ++ E+ K E K+RE+E QE+
Sbjct: 566 QEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQE 625
Query: 462 KNWEIRER-KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
+ +IRE+ +K RE E+ + +EE+ E ++ +E +++ ++ ++
Sbjct: 626 E--KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM--------WRQEE 675
Query: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580
++R++EK++ E + ++E ++E +++ + + E + EQE + RR QE
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-----QE 730
Query: 581 PESEEEEEEKQEKEEKREE 599
+ E+E +++EEK +E
Sbjct: 731 EKMWEQEVRLRQQEEKMQE 749
Score = 134 bits (338), Expect = 3e-31
Identities = 113/495 (22%), Positives = 257/495 (51%), Gaps = 51/495 (10%)
Query: 154 EKKLLVKVDAKTKAQ--LDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI---K 208
E+ L K KA ++E ++ A + T+T+++ + + + + + Q++ K
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237
Query: 209 GAIEVLIREYSSELNA-----PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKED 263
I++ ++E +L P Q+ + KE + V+ + + E
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-------VSAKLQAQVEENEL 290
Query: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERE 319
N + +++++ + R+ K ++ +K++E++ K +EK R++ EK RR+ E E+E
Sbjct: 291 WNRLNQQQEEK--MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 320 RERRERER---EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSD 376
+ R +E E+E + R++E E+E + R + E++ ++ RE + +
Sbjct: 349 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKIRELEEKMHEQEKIR 407
Query: 377 RNKDRSRSREKSRDRERERERERERERERERERERERE-REREREREREREKDKKRDREE 435
+++ + EK R++E+ +E+E + R+ E+ RE+E + RE+E++ R+ EK ++++
Sbjct: 408 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 436 DEEDAYERRKL---ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKE 492
+EE E+ ++ E K+ E+E ++++ K E + +K R+ E++ R+EE+ RE ++
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE--QEEKIRKQEEKVWRQEEKIREQEEK 525
Query: 493 AKRLKEFLEDYDDD-RDDPKYYRGSALQKRLRDREKEMEADERDRK-----REKEELEEI 546
+ +E + ++ R+ + +R ++++ ++EK E ++R + R++E++ E
Sbjct: 526 IREQEEKMWRQEEKIREQEEMWRE---EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ 582
Query: 547 RQRLLAEGHPDPDAELQRMEQEAE--------RRRQPQIKQEPESEEEEEEK-QEKEEKR 597
+++ + + E +R EQE + R ++ +I+++ E E+EEK +E+EE
Sbjct: 583 EEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMT 642
Query: 598 EEPMEEEEEPEQKPC 612
+E E+ E E+K C
Sbjct: 643 QEQEEKMGEQEEKMC 657
Score = 132 bits (332), Expect = 1e-30
Identities = 118/479 (24%), Positives = 243/479 (50%), Gaps = 41/479 (8%)
Query: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQM-IKGAIEVLIREYSSELNAPSQE 228
D WK + + T + ++E TK RD + ++ + E E NA QE
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 229 SDSHPRKKKKEKK---EDIFRRFPVAPLI--PYPLITKEDINAIEMEEDKRDLISR--EI 281
+K E + +++ R+ A L+ L + D E++ L ++ E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERE-RERERERREREREREREREREKEKE 340
+ +++ EE+ ++E++ QE E++ +E+E + RE+E + RE+E + R+ E EKE
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 341 R----------ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
E+E + R + E++ R+ + ++E +++ +EK R+
Sbjct: 349 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 408
Query: 391 RERER-ERERERERERERERERERERERERERERE---REKDKKRDREEDEEDAYERRKL 446
+E +R E E+ RE+E+ +E+E + R+ E+ RE+E RE++KK R+E++ E+ +
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468
Query: 447 ERKLREKEAAYQ------ERLKNWEIRER-----KKTREYEKEAEREEERRREMAKEAKR 495
E K +E+E ++ E+ + W +E+ +K R+ E++ R+EE+ RE ++ +
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 496 LKEFLEDYDDD-RDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEG 554
+E + ++ R+ + +R ++++ ++EK E ++R + +K +E + R E
Sbjct: 529 QEEKMWRQEEKIREQEEMWRE---EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEK 585
Query: 555 HPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK---REEPMEEEEEPEQK 610
+ +++ E++ + + + KQE + E+EE+ QE+EEK +EE + E+EE Q+
Sbjct: 586 VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Score = 119 bits (297), Expect = 2e-26
Identities = 125/544 (22%), Positives = 252/544 (46%), Gaps = 114/544 (20%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNA----PSQESD 230
KKK N PET T+ + ++E K Q E L RE ++++ Q+++
Sbjct: 86 KKKKINNGTNPETTTSGGCHSPEDEQKASHQ----HQEALRRELEAQVHTIRILTCQKTE 141
Query: 231 --------SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
H K+ + + D+ R + L ++ ++A+ ++ K D E++
Sbjct: 142 LQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELT 199
Query: 283 KFRD-----------THKKLEEEKGKKEKERQEIEKERRE-----RERERERER------ 320
K RD T ++L+E+ K +++ Q +E E+ E +E +R+ ER
Sbjct: 200 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 259
Query: 321 --------------------------------ERREREREREREREREK-----EKERER 343
R +++E + R+ EK EK +E+
Sbjct: 260 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ 319
Query: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
E + ++ +E++ R+ + ++E R ++ +E+ R+ E E+E +
Sbjct: 320 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 379
Query: 404 ERERE------------REREREREREREREREREKDKK-RDREEDEEDAYERRKLERKL 450
R+ E E+ E+E+ RE+E +R++++K R++E+ +E + + E K+
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 451 REKEAAYQERLKN-W----EIRERKKTREYEKEAEREEERRRE----MAKEAKRLKEFLE 501
RE+E +E+ K W +I E++K RE EK E+EE R+E +E R KE +
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 502 DYDDD--RDDPKYYRGS----ALQKRLRDREKEM-EADERDRK-----REKEELEEIRQR 549
+ ++ + + K +R ++++R++E++M +E+ R+ RE+E++ E +
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 550 LLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE---KREEPMEEEEE 606
E + + ++ R E++ + + +QE + E+EE++QE+EE K+EE + E+EE
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEE 619
Query: 607 PEQK 610
Q+
Sbjct: 620 KIQE 623
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 149 bits (375), Expect = 1e-35
Identities = 91/276 (32%), Positives = 149/276 (53%), Gaps = 19/276 (6%)
Query: 278 SREISKFRDTHKKLEEEKG-KKEKERQEIEKERRERERERERERE-RRERERERERERER 335
SR S R+ H ++ ++EKERQ +E+E +ERE+ER R R R ER R R RER
Sbjct: 276 SRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER 335
Query: 336 EKEKERERERERD-RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR--- 391
+ + R R+R+ D RDRDR +E++ +R R RDRD D+ER ++R K+R RSRE+S+++
Sbjct: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
Query: 392 ----EREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
E++ + +++ R R+ +R+ ++E++ R R RER K + R R + R E
Sbjct: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKE 454
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE--FLEDYDD 505
+ + K + ++ K + +T EK +RE +E +++ R KE D+ D
Sbjct: 455 KSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD 514
Query: 506 DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE 541
+D S R R + E E+ E+ K + E
Sbjct: 515 SKDQ------SDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 140 bits (352), Expect = 6e-33
Identities = 87/314 (27%), Positives = 156/314 (49%), Gaps = 20/314 (6%)
Query: 303 QEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD 362
++I+K+ +E E +R ERR R R R + R R R R+ + DR+ +
Sbjct: 238 RKIKKDGKEGAEEIDRHVERR-RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELE 296
Query: 363 RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER-ERERER 421
RE++R R + +R K+R RSR R ER R R RER R R R R+R+ +R +R+RER
Sbjct: 297 REKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356
Query: 422 EREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER 481
E+E E+ ++RDR+ D+E ER K + RE+ E R R + E + + ++
Sbjct: 357 EKENERGRRRDRDYDKERGNEREKERERSRERSK---------EQRSRGEVEEKKHKEDK 407
Query: 482 EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE 541
++ R R+ +++K+ K+ +R R KR R R KE + ++ +EK
Sbjct: 408 DDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKS 467
Query: 542 ELEEIRQRLLAEGHPDPDAELQR------MEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595
R R ++G D + ++ E+ +R R + + + + +++ + +
Sbjct: 468 NK---RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR 524
Query: 596 KREEPMEEEEEPEQ 609
+R + +E+E + +Q
Sbjct: 525 RRSQSIEQESQEKQ 538
Score = 92.0 bits (227), Expect = 2e-18
Identities = 62/245 (25%), Positives = 123/245 (50%), Gaps = 17/245 (6%)
Query: 198 EETKRRDQMIKGAIE---VLIRE-YSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL 253
E+ +RR + I +E RE + S + ++ D R +++EK+ + RR
Sbjct: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRD-- 369
Query: 254 IPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERE 313
KE N E E ++ SRE SK + + ++EE+K K++K+ + ++R+ +
Sbjct: 370 -----YDKERGNEREKERER----SRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420
Query: 314 RERERERERREREREREREREREKEKERERERERDR-DRDRTKERDRDRDRERDRDRDRE 372
+E++ R R + R R R R K R R R +++ + + + +++ R R + R
Sbjct: 421 KEKKHSRSRSRERKHRSRSRSRNAGK-RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRT 479
Query: 373 RSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRD 432
S +++K R S K + R+R R +ER +R+ +++ + +R R + E+E +K+
Sbjct: 480 DSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQH 539
Query: 433 REEDE 437
+ +DE
Sbjct: 540 KNKDE 544
Score = 80.9 bits (198), Expect = 5e-15
Identities = 86/371 (23%), Positives = 151/371 (40%), Gaps = 78/371 (21%)
Query: 370 DRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDK 429
D++ + K + +E + + +R ER R R R R R R R RE
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
Query: 430 KRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREM 489
DRE + E ER++LER+ +E+E +ER+++R ++ ER R RE
Sbjct: 290 SFDRELEREK--ERQRLEREAKERE------------KERRRSRSIDRGLERRRSRSRE- 334
Query: 490 AKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQR 549
+ R R R ++ + D RDR RE+E+ E +R
Sbjct: 335 -----------------------------RHRSRSRSRDRKGDRRDRDREREKENERGRR 365
Query: 550 LLAEGHPDPDAELQR---MEQEAERRRQPQIKQEPESE-EEEEEKQEKEEKREEPMEEEE 605
D D + +R E+E ER R+ +Q E EE++ K++K+++R + +
Sbjct: 366 R------DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS 419
Query: 606 EPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPK 665
+ E+K + + S S +G + + ++S H+N ++
Sbjct: 420 KKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS-----KHKNESKEK-------- 466
Query: 666 IGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNAT 725
S K S S G+ +SV++ K K E S + RKR + D + +
Sbjct: 467 ---SNKRSRSGSQGRTDSVEKSK--------KREHSPSKEKSRKRSRSKERSHKRDHSDS 515
Query: 726 KGTVNTEEKRK 736
K + ++R+
Sbjct: 516 KDQSDKHDRRR 526
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 147 bits (370), Expect = 5e-35
Identities = 112/442 (25%), Positives = 234/442 (52%), Gaps = 35/442 (7%)
Query: 196 LDEETKRRDQM-IKGAIEVLIREYSSELNAPSQESDSHPRKKK-------KEKKEDIFRR 247
++E TK RD + ++ + E + NA QE +K KE K + R
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERA 258
Query: 248 FPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK---------- 297
+ P + + +E E ++ I ++ K ++L E++GK
Sbjct: 259 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWR 318
Query: 298 KEKERQEIEKERRERERERERERERRERERERERERER---EKEKERERERERDRDRDRT 354
+EK +E EKE RE+E+E ++E RE+E + + + E+ ++EK RE+E + R +R
Sbjct: 319 QEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378
Query: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERER-ERERERERERERER 413
E+++ + + RD+E +R R +E+ R RE+E+ E+ E+ RE ++ +E+E+
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKEE-RMREQEKMWEQVEKMREEKKMQEQEK 437
Query: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTR 473
+ + E+ +E E+ ++R+++ EE+ R + E+ +++E +++ K W+ + + +
Sbjct: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 497
Query: 474 EYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM-EAD 532
E E E+ +E+ ++ ++ +++++ E + ++ K +R Q+++R++E +M E +
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK---KMWR----QEKMREQEDQMWEQE 550
Query: 533 ERDRKREK---EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
E+ R +E+ ++ E + ++ + D E + E+E R R+ ++++E E E+EE
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Query: 590 K-QEKEEKREEPMEEEEEPEQK 610
K QE+EEK +E E+ E E+K
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEK 632
Score = 140 bits (354), Expect = 4e-33
Identities = 112/490 (22%), Positives = 256/490 (52%), Gaps = 58/490 (11%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGN-ARPETVTNDDEEAL---DEETKRRDQMIKG 209
++KL + K++ QL+ + K+K P+ TN +E + +EE + +++ I+
Sbjct: 231 QEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRK 290
Query: 210 AIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEM 269
E + R+ E QE +++K ++E R E+
Sbjct: 291 QEEKMWRQ---EERLREQEGKMREQEEKMWRQEKRLRE-----------------QEKEL 330
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERERERRER 325
E +++L RE + R+ ++++E++ K +EK R++ EK R+ ER E+E++ RE+
Sbjct: 331 REQEKEL--REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388
Query: 326 EREREREREREKEKERERERERDRDRDRTKERDR-DRDRERDRDRDRERSSDRNKDRSRS 384
E++ + ER E++ + +R R++ K ++ ++ RE + +++E+ + +++ +
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 385 REKSRDRERERERERERERERERERERERER---ERERERERER---EKDKKRDREEDEE 438
E+ R+RE++ E E RE+E + +++ E + E+E +++R +K+K ++E+ +E
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Query: 439 DAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
+ + E K+R++E + + K W ++K RE E + +EE+ R+ ++ +E
Sbjct: 509 QEEKIWEQEEKIRDQEEMWGQEKKMWR---QEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 499 FLEDYDDDRDDPKYYRGSAL--QKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
+E +++ + + + ++R+R+REK+M +E + ++E+++E +++ +
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 557 --DPDAELQRMEQEAERRRQPQIKQE---------PESEEE--EEEK---QEKEEKREEP 600
+ + ++Q E++ + + +QE PE +E+ E EK QEK +++EE
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 601 MEEEEEPEQK 610
+ E+E+ E+K
Sbjct: 686 IWEQEKMEKK 695
Score = 137 bits (345), Expect = 4e-32
Identities = 119/474 (25%), Positives = 241/474 (50%), Gaps = 53/474 (11%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV 213
++K L + + + + Q E + +K+ + E + +E+ ++E K R+Q K
Sbjct: 319 QEKRLREQEKELREQEKELREQKELRE---QEEQMQEQEEKMWEQEEKMREQEEK----- 370
Query: 214 LIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK 273
+ E QE +++K +E+ + ++D E EE
Sbjct: 371 ---MWRQEERLWEQEKQMREQEQKMRDQEE--------------RMWEQDERLREKEERM 413
Query: 274 RDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE---RE 330
R E K + +K+ EEK +E+E++ ++E + +E ER RERE++ RE E RE
Sbjct: 414 R-----EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 331 REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
+E + +K++E E+E + + +++ E+++ +++E +++ R +E+
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 391 RERE---RERERERERERERERERERERER------EREREREREKDKKR-DREEDEEDA 440
+E++ +E+ RE+E + + E+ R++E+ ER ++ +E++KK D+EE +
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE---ERRREMAKEAKRLK 497
R+ E+K+RE+E +E+ + + +E K + EK E+EE E+ +M ++ +++
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMW 648
Query: 498 EFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPD 557
E E + + P+ ++++++EK E +E+ ++EK E + Q
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE-----KKT 703
Query: 558 PDAELQRMEQEAERRRQPQIKQEPESEEEEEEK-QEKEEKREEPMEEEEEPEQK 610
D E R E+E+ R R+ ++++E E E+EEK QE+EEK +E EE E E+K
Sbjct: 704 WDQEKMR-EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
Score = 137 bits (345), Expect = 4e-32
Identities = 112/505 (22%), Positives = 261/505 (51%), Gaps = 60/505 (11%)
Query: 135 KEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDE-WKAKKKASNGNARPETVTNDDE 193
+E E LR + ++ E+K L + + + + Q ++ W+ ++K + E + +E
Sbjct: 324 REQEKELRE----QEKELREQKELREQEEQMQEQEEKMWEQEEKMRE---QEEKMWRQEE 376
Query: 194 EALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL 253
++E + R+Q E +R+ + E D R+K++ +E V +
Sbjct: 377 RLWEQEKQMREQ------EQKMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKM 426
Query: 254 IPYPLITKEDINAIEMEEDKRDLISR--EISKFRDTHKKLEEEKGKKEKERQEIEK---- 307
+E+ E E+ RD + E + R+ KK+ EE+ ++ ++++K
Sbjct: 427 -------REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 308 --ERRERERERERERERREREREREREREREKEKERERERERDRD-----------RDRT 354
E+ E+E +++R E++E+ E+E+ +E+E++ + E+ RD++ +++
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 355 KERDRDRDRERDRDRDRERS----SDRNKDRSRSREKSRDRERERERERERERERERERE 410
+E++ + ++ RD+E+ +R + +++ +EK + E+ RE ER RERE++
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Query: 411 REREREREREREREREKDKKRDREED--EEDAYERRKLERKLREKEAAYQERLKNWEIR- 467
E E RE+E + + +++K +++EE E++ + + E+ ++E +++ K WE +
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 468 ---ERKKTREYEKEAEREE-ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLR 523
+++K E+EK E+E+ + + E E +++++ ++ + D + R ++ +R
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE---EESMR 716
Query: 524 DREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES 583
+REK+M +E + ++E+++E +++ + + E + EQE + Q ++ ++ E
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Query: 584 --EEEEEEKQEKEEKREEPMEEEEE 606
E E+ ++QEK ++EE M ++EE
Sbjct: 777 LWEHEKMQEQEKIWEQEEKMRDQEE 801
Score = 136 bits (343), Expect = 7e-32
Identities = 111/484 (22%), Positives = 234/484 (48%), Gaps = 51/484 (10%)
Query: 149 DLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIK 208
D ++ EK+ ++ K Q+++ + +KK E T D EE + EE + R++
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQE----QEKKTRDQEEKMQEEERIRER--- 455
Query: 209 GAIEVLIREYSSELNAPSQESDSHPRKK-KKEKKEDIFRRFPVAPLIPYPLITKEDINAI 267
E +RE + ++ ++E+KE +R P KE +
Sbjct: 456 ---EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ---------KEKLWEQ 503
Query: 268 EMEEDKRDLISREISKFRDTH------KKLEEEKGKKEKERQEIEKERRERERER---ER 318
E +++ + I + K RD KK+ ++ +E+E Q E+E + R++E+ ++
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563
Query: 319 ERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378
E ++ +E+E++ ++EK RE ER R+R++ +E + R++E E+ ++
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Query: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDR-EEDE 437
+ EK +++E + + E+ E+E + ++ ++E+ E EK +++++ +E E
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQE 683
Query: 438 EDAYERRKLERKLREKEAAYQERLKNWE---IRERKKTREYEKEAEREEERRREMAKEAK 494
E +E+ K+E+K +E+E K W+ +RE + RE EK+ EEE RE ++ +
Sbjct: 684 EKIWEQEKMEKKTQEQEK------KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
Query: 495 RLKEFLEDYDDD---------RDDPKYYRGSAL---QKRLRDREKEMEADERDRKREKEE 542
+E +++ +++ + K + L +++L + EK E ++ + EK
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
Query: 543 LEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPME 602
+E + R E + +++ E++ + + QE + +EE+ +EEK EE M+
Sbjct: 798 DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
Query: 603 EEEE 606
+EE
Sbjct: 858 GQEE 861
Score = 115 bits (289), Expect = 1e-25
Identities = 100/351 (28%), Positives = 178/351 (50%), Gaps = 27/351 (7%)
Query: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336
+ R +S HKK + + KER + E E +++ +E+ E E
Sbjct: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240
Query: 337 KEKERERERERDRDRDRTK---ERDRDRDRERDRDRDRERSSDRNKDRSRSREKS-RDRE 392
K + + +E R +R K + + + + R E ++ K + EK R E
Sbjct: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE 300
Query: 393 RERERE---RERERERERERERERERERE-RERERE-REKDKKRDRE----EDEEDAYER 443
R RE+E RE+E + R+ +R RE+E+E RE+E+E RE+ + R++E E EE +E+
Sbjct: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
Query: 444 RKLERKLREKEAAYQERLKNWE----IRER-KKTREYEKEAEREEERRREMAKEAKRLKE 498
+ R+ EK +ERL WE +RE+ +K R+ E+ ++ER RE + + ++
Sbjct: 361 EEKMREQEEKMWRQEERL--WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 499 FLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDP 558
E + R++ K +K+ RD+E++M+ +ER R+REK+ EE + + +
Sbjct: 419 MWEQVEKMREEKKM---QEQEKKTRDQEEKMQEEERIREREKKMREE-EETMREQEEKMQ 474
Query: 559 DAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK---REEPMEEEEE 606
E EQE + +Q ++ ++ E E+E+ QE+EEK +EE + ++EE
Sbjct: 475 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
Score = 110 bits (275), Expect = 5e-24
Identities = 102/454 (22%), Positives = 215/454 (47%), Gaps = 90/454 (19%)
Query: 162 DAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSE 221
+ K + Q + W +KK R E + +++ ++E K RDQ K + +E E
Sbjct: 517 EEKIRDQEEMWGQEKKMW----RQEKMREQEDQMWEQEEKMRDQEQK----MWDQEERME 568
Query: 222 LNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREI 281
QE + +++K ++E + R K+ EM ++ + + +
Sbjct: 569 KKTQEQEKKTWDQEEKMREEERMRER------------EKKMREEEEMMREQEEKMQEQE 616
Query: 282 SKFRDTHKKL--EEEKGKKEKERQEIEKERRERERERERERERRERERER--EREREREK 337
K ++ +K+ +EEK ++++E+ ++E+ + E+ E++R ++E+ E E+ +E+
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 338 EKERERER---ERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE 394
EK +E+E E+++ +T+E+++ K+ D+E+
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEK---------------------------KTWDQEKM 709
Query: 395 REREREREREREREREREREREREREREREREKDKKRDRE--EDEEDAYERRKLERKLRE 452
RE E RERE++ E E RE+E + + + EK ++++ E E EE +E+ E K+ E
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ---EEKMWE 766
Query: 453 KEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKY 512
++ +++ K W E +K +E EK E+EE+ RD +
Sbjct: 767 QQRLPEQKEKLW---EHEKMQEQEKIWEQEEKM---------------------RDQEEK 802
Query: 513 YRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR 572
RG ++++R +E++M E ++E++ +++ + + ++ E++ E +
Sbjct: 803 MRGQ--EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ-----EEKMWGQEEKMEEK 855
Query: 573 RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
Q Q ++ E EE+ ++EK ++EE M +EE
Sbjct: 856 MQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 71.6 bits (174), Expect = 3e-12
Identities = 72/284 (25%), Positives = 133/284 (46%), Gaps = 33/284 (11%)
Query: 332 EREREKEKERERERERDRD-RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
E +R R ++ DR + TKERD + R+ + + K + +EK
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDA---LSLELYRNTITNEELKKKNAELQEKLPL 236
Query: 391 REREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKL 450
E E+ + +E +R+ ER + + + +E+ ++ EE+ E+ K RK
Sbjct: 237 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ-----EEELREQEKKIRKQ 291
Query: 451 REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDP 510
EK +ERL+ E K RE E++ R+E+R RE KE + ++ L +
Sbjct: 292 EEKMWRQEERLREQE----GKMREQEEKMWRQEKRLREQEKELREQEKELRE-------- 339
Query: 511 KYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAE 570
QK LR++E++M+ E ++E++ E +++ + + E Q EQE +
Sbjct: 340 --------QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 571 RRRQPQI--KQEPESEEEEEEKQEKEEKRE--EPMEEEEEPEQK 610
R Q + +Q+ E+EE +E+E+ E E M EE++ +++
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Score = 62.8 bits (151), Expect = 1e-09
Identities = 62/235 (26%), Positives = 113/235 (48%), Gaps = 21/235 (8%)
Query: 384 SREKSRDRERERERERERER---EREREREREREREREREREREREKDKKRDREEDEEDA 440
+R K DR E E +ER+ E R E +++ +E+ + ++ E + +
Sbjct: 190 TRHKKADRYIE-ELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNV 248
Query: 441 YE-RRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
E +RKLER L+ R+ ++ RE EK+ ++EE+ M ++ +RL+E
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEK---MWRQEERLRE- 304
Query: 500 LEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPD 559
++ + K +R +KRLR++EKE+ E++ + +KE E+ Q +
Sbjct: 305 -QEGKMREQEEKMWRQ---EKRLREQEKELREQEKELREQKELREQEEQM--------QE 352
Query: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLK 614
E + EQE + R Q + E E+EKQ +E++++ +EE EQ L+
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 146 bits (369), Expect = 7e-35
Identities = 81/196 (41%), Positives = 131/196 (66%), Gaps = 10/196 (5%)
Query: 298 KEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKER 357
+E+ER+ ++ ++ERE ER++ERRERE+ R+REREKE++RER ++ + + +ER
Sbjct: 39 REREREIETRKEGKKERESERKKERREREK---RKREREKERKRERGKKEKKGERKKEER 95
Query: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
+R + R +++ E R K + R ++ +ERER+ ER+RE +ERER++E
Sbjct: 96 ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE--- 152
Query: 418 EREREREREKDKKRDREEDEEDAYERRKLERKLREK-EAAYQERLKNWEIRERKKTREYE 476
ERE+ERER++ KKR+R++ E ER++ ERK R+K E +ER K RERK+ RE +
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE---RERKERRERK 209
Query: 477 KEAEREEERRREMAKE 492
KE +++EER++E K+
Sbjct: 210 KERKKKEERKKERQKD 225
Score = 134 bits (338), Expect = 3e-31
Identities = 85/244 (34%), Positives = 139/244 (56%), Gaps = 40/244 (16%)
Query: 306 EKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRER 365
+ E RERERE E +E + +ERE ER++ER + ++R+RERE++R R+R K+ + ++
Sbjct: 35 QSEIREREREIETRKEGK-KERESERKKERREREKRKREREKERKRERGKKEKKGERKKE 93
Query: 366 DRDRDRERSSDRNKDRSRSREKSRDRERERERERER-ERERERERERERERERERERERE 424
+R+R K R R +E E+E+ +++E+ ER R + +ERER+ ER+RE
Sbjct: 94 ERER---------KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 425 REKDKKRDREEDEEDAYERRKLERK-LREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
+E+++K++ E E + ER+K ERK + EKE E K E +ERKK KE ++E
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKE----EERKEKERKERKKRERNRKERKKER 200
Query: 484 ER--RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE 541
ER RRE KE K+ +E R ++R+K+ + + R+++R K
Sbjct: 201 ERKERRERKKERKKKEE----------------------RKKERQKDRQTNWREKERGKR 238
Query: 542 ELEE 545
E +E
Sbjct: 239 ERKE 242
Score = 134 bits (337), Expect = 4e-31
Identities = 71/198 (35%), Positives = 127/198 (64%), Gaps = 10/198 (5%)
Query: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320
KE + + E +R+ RE K R + +E+KG+++KE +E +K RRE+E + E+
Sbjct: 53 KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEK 112
Query: 321 ERREREREREREREREKEKERERERERDRD----RDRTKE-RDRDRDRERDRDRDRERSS 375
E+R+++ ++ER R ++ KERER+ ER R+ R+R KE R+++R+R+ + R+R++
Sbjct: 113 EKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVG 172
Query: 376 DRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREE 435
++ ++R K R + +ER++ERER+ RER++ER+++ ER++ER+KD++ + E
Sbjct: 173 EKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWRE 232
Query: 436 DEEDAYERRKLERKLREK 453
ER K ERK R+K
Sbjct: 233 K-----ERGKRERKERKK 245
Score = 132 bits (333), Expect = 1e-30
Identities = 76/206 (36%), Positives = 130/206 (63%), Gaps = 13/206 (6%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
+E K++ S + R+ K+ E + ++++ER + EK+ ++ ERER++ RRE+E +
Sbjct: 49 KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108
Query: 330 EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRER-SSDRNKDRSRSREKS 388
E+E+ K+KE+ +ER R KER+R +R+R+ ++RER +R K+R R K
Sbjct: 109 GEEKEKRKKKEK---KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK 165
Query: 389 RDRERERERERER-ERERERERERERER-EREREREREREKDKKRDREEDEEDAYERRK- 445
R+R++ E+E ER E+ER+ ++RER R ER++ERER+ +++K++R++ EE ER+K
Sbjct: 166 RERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKD 225
Query: 446 LERKLREKEAAYQERLKNWEIRERKK 471
+ REKE +ER +ERKK
Sbjct: 226 RQTNWREKERGKRER------KERKK 245
Score = 129 bits (325), Expect = 9e-30
Identities = 76/230 (33%), Positives = 128/230 (55%), Gaps = 25/230 (10%)
Query: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
+S RE+ R+ E +E ++ERE ER++ER +R+RERE+ER+RE+ KK + E +++
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
ER+K R+ KE +E+ K E +ER +T + KE ER+EER+RE KE +R KE
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE-- 152
Query: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
+REKE E ER ++ K+ E+ +R E
Sbjct: 153 -----------------------EREKERERKERKKRERKQVGEKEEERKEKERKERKKR 189
Query: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
E R E++ ER R+ + +++ E +++EE K+E+++ R+ E+E +++
Sbjct: 190 ERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRE 239
Score = 83.2 bits (204), Expect = 9e-16
Identities = 57/208 (27%), Positives = 109/208 (52%), Gaps = 19/208 (9%)
Query: 171 EWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP-SQES 229
E K ++++ R E E + + +R + KG + RE ++E
Sbjct: 50 EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG 109
Query: 230 DSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHK 289
+ ++KKKEKKE +KE EE KR+ +E + ++ +
Sbjct: 110 EEKEKRKKKEKKER-------------GRTSKEGKERERKEERKREE-RKERERKKEERE 155
Query: 290 KLEEEKGKKEKERQEIEKERRERERERERERERRERER-EREREREREKEKERERERERD 348
K E K +K++ER+++ ++ ER+ + +ER++RER R ER++ERER++ +ER++ER++
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKK 215
Query: 349 RDRDRTKERDRD---RDRERDRDRDRER 373
+R + +++DR R++ER + +ER
Sbjct: 216 EERKKERQKDRQTNWREKERGKRERKER 243
Score = 35.4 bits (80), Expect = 0.22
Identities = 18/55 (32%), Positives = 33/55 (60%), Gaps = 2/55 (3%)
Query: 556 PDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
P +E++ E+E E R++ K+E ESE ++E ++ ++ KRE E + E +K
Sbjct: 32 PGWQSEIREREREIETRKEG--KKERESERKKERREREKRKREREKERKRERGKK 84
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 145 bits (366), Expect = 2e-34
Identities = 75/199 (37%), Positives = 139/199 (69%), Gaps = 12/199 (6%)
Query: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKE---KERERER 345
K + + +++KER+E EK +RERE+ER+RER ++E+++ ++RER +E+E KERE++R
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 346 ERDRDRDRTKERDRDRDRERDRDRDRERSSDRN-KDRSRSREKSRDRERERERERERERE 404
+ R+++R K + + RER + RER + K+R R ++ R+R+R++ R+++R +E
Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 405 RERERER-EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
R+RE+ER +RER+R++ ++ EREK ++R+R+E ++ ER + ER+ R+KE + R K
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKK---ERERKERRERKKERKKERRKK- 202
Query: 464 WEIRERKKTREYEKEAERE 482
+ERKK R+ +++ + +
Sbjct: 203 ---KERKKDRKTDRQTDSQ 218
Score = 144 bits (364), Expect = 3e-34
Identities = 81/209 (38%), Positives = 140/209 (66%), Gaps = 10/209 (4%)
Query: 313 ERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR-DRDR 371
+RE ER++ERRERE+ R+REREKE++RER + +++ + K+R+R ++RER R +R++
Sbjct: 31 QRESERKKERREREK---RKREREKERKRERGK---KEKKKRKKRERGKERERKRKEREK 84
Query: 372 ERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKR 431
+R R K+R + +++ + RER++ RER++++ER +ERERE ++ RER+R++ + KKR
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKR 143
Query: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
+E E +R+ +RK R+KE ++R +N +ERKK RE ++ ER++ER++E K
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERN--RKERKKERERKERRERKKERKKERRK 201
Query: 492 EAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
+ +R K+ D D + R SA +
Sbjct: 202 KKERKKDRKTDRQTDSQVFRPLRESAFNR 230
Score = 143 bits (360), Expect = 8e-34
Identities = 72/198 (36%), Positives = 133/198 (67%), Gaps = 18/198 (9%)
Query: 297 KKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKE 356
++E ER++ +ER +R+RERE+ER+R ++E+++ ++RE+ KERER+R ++R++ R +
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR-KEREKQRKER 89
Query: 357 RDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE 416
R+++R + + + RER ++R + +E+ ++RERE ++ RER+R++ R+++R +ER+
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKRRKERK 148
Query: 417 REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE 476
RE+ER + K KKR +EE E ++R+ RK R+KE RERK+ RE +
Sbjct: 149 REKERGKRERKRKKRKKEERE----KKRERNRKERKKE------------RERKERRERK 192
Query: 477 KEAEREEERRREMAKEAK 494
KE ++E +++E K+ K
Sbjct: 193 KERKKERRKKKERKKDRK 210
Score = 139 bits (351), Expect = 8e-33
Identities = 73/173 (42%), Positives = 123/173 (71%), Gaps = 10/173 (5%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
+E KR+ +E K + + E E+ +KE+E+Q KERRE+ER R+R++E+++RER++
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKEREKQR--KERREKER-RKRKKEKKKRERKQ 108
Query: 330 EREREREKEKER-ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
RER+K+KER ERERE + R+R +++ R + R ++R R++ER ++R R + K
Sbjct: 109 RGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGK---RERKRKKRKK 165
Query: 389 RDRERERER---EREREREREREREREREREREREREREREKDKKRDREEDEE 438
+RE++RER ER++ERER+ RER++ER++ER +++ER+KD+K DR+ D +
Sbjct: 166 EEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 136 bits (343), Expect = 7e-32
Identities = 72/190 (37%), Positives = 129/190 (67%), Gaps = 12/190 (6%)
Query: 271 EDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERE 330
E K++ RE K R+ K+ + E+GKKEK K+R++RER +ERER+R+ERE++R+
Sbjct: 35 ERKKERREREKRK-REREKERKRERGKKEK------KKRKKRERGKERERKRKEREKQRK 87
Query: 331 REREREKEKERERERERDRDRDRTKERDRDRDR-ERDRDRDRERSSDRNKDRSRSREKSR 389
RE+E+ K ++ +++R+R + +ER + ++R ER+R+ + R R K R + R K R
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 390 DRERER-ERERERERERERERERERER---EREREREREREKDKKRDREEDEEDAYERRK 445
RE+ER +RER+R++ ++ ERE++RER ER++ERER+ +++K++R+++ ER+K
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Query: 446 LERKLREKEA 455
+ R+ ++
Sbjct: 208 DRKTDRQTDS 217
Score = 120 bits (301), Expect = 5e-27
Identities = 68/207 (32%), Positives = 123/207 (59%), Gaps = 23/207 (11%)
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
+RE ER ++R ++R R+R++ER R+R ++ R K R R +E+ R R +ERE++R+
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKK-RERGKERERKR-KEREKQRKE 88
Query: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
RE+ER + ++ +++RER++ RE+ KK++R+E E + +RR+ +RK R K+ +ER
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR 521
+ E +R++ R+ K+ ERE++R R KE K+ +E +K
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERN-RKERKKERE--------------------RKE 187
Query: 522 LRDREKEMEADERDRKREKEELEEIRQ 548
R+R+KE + + R +K K++ + RQ
Sbjct: 188 RRERKKERKKERRKKKERKKDRKTDRQ 214
Score = 119 bits (297), Expect = 2e-26
Identities = 75/236 (31%), Positives = 127/236 (53%), Gaps = 44/236 (18%)
Query: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
RE R +ER +R+RERE+ER+RER + +E+++ ++RER K+++R R+E E+ ERR
Sbjct: 32 RESERKKERREREKRKREREKERKRERGK-KEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
+ ER+ R+KE +ER + RERKK +E KE ERE ++RRE ++ +R K
Sbjct: 91 EKERRKRKKEKKKRERKQRGR-RERKKKKE-RKERERENKQRRERKRKKRRKK------- 141
Query: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQR 564
KR ++R++E E +R+RKR+K + EE
Sbjct: 142 ---------------KRRKERKREKERGKRERKRKKRKKEE------------------- 167
Query: 565 MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPI 620
E++ ER R+ + K+ E E +K+ K+E+R++ +++ + RP+
Sbjct: 168 REKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPL 223
Score = 115 bits (288), Expect = 2e-25
Identities = 77/236 (32%), Positives = 134/236 (56%), Gaps = 49/236 (20%)
Query: 372 ERSSDRNKDRSRSREKSRDRERERERER-EREREREREREREREREREREREREREKDKK 430
+R S+R K+R ++ R+RE+ER+RER ++E+++ ++RER +ERER+R +EREK +K
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR---KEREKQRK 87
Query: 431 RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMA 490
ERR+ ER+ R+KE +ER K RERKK +E KE ERE ++RRE
Sbjct: 88 -----------ERREKERRKRKKEKKKRER-KQRGRRERKKKKE-RKERERENKQRRERK 134
Query: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
++ +R K KR ++R++E E +R+RKR+K + EE ++
Sbjct: 135 RKKRRKK----------------------KRRKERKREKERGKRERKRKKRKKEEREKK- 171
Query: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
E R E++ ER R+ + +++ E ++E +K+E+++ R+ + + +
Sbjct: 172 ---------RERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 95.9 bits (237), Expect = 1e-19
Identities = 58/227 (25%), Positives = 114/227 (50%), Gaps = 31/227 (13%)
Query: 163 AKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSEL 222
+K Q + + K++ + E E +E K+R + +G R+ +
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 223 NAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
+E + RKK+K+K+E ++ RE
Sbjct: 86 RKERREKERRKRKKEKKKRE------------------------------RKQRGRRERK 115
Query: 283 KFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERE 342
K ++ ++ E K ++E++R++ K++R +ER+RE+ER +RER+R++ ++ EREK++ER
Sbjct: 116 KKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN 175
Query: 343 RERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSR 389
R +ER ++R+R + R+R ++R+++R + +ER DR DR + R
Sbjct: 176 R-KERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFR 221
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/101 (27%), Positives = 55/101 (54%)
Query: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
P R S +K R+REK E++RKRE+ + E+ +++ G +R +Q
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87
Query: 570 ERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
ERR + + K++ E ++ E +++ + E++++ +E E E K
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128
Score = 48.5 bits (114), Expect = 3e-05
Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 1/95 (1%)
Query: 516 SALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575
S + K RE E + + R+R++ K E E+ R+R + + +R +E ER+R+
Sbjct: 23 SHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRER-GKERERKRKE 81
Query: 576 QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
+ KQ E E+E K++KE+K+ E + +K
Sbjct: 82 REKQRKERREKERRKRKKEKKKRERKQRGRRERKK 116
Score = 31.2 bits (69), Expect = 4.2
Identities = 17/62 (27%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 549 RLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
++++ H + E++ ERR + + K+E E E + E+ +KE+K+ + E +E E
Sbjct: 18 QMVSCSHISKPCTQRESERKKERREREKRKREREK-ERKRERGKKEKKKRKKRERGKERE 76
Query: 609 QK 610
+K
Sbjct: 77 RK 78
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 140 bits (352), Expect = 6e-33
Identities = 121/488 (24%), Positives = 248/488 (50%), Gaps = 59/488 (12%)
Query: 154 EKKLLVKVDAKTKAQ--LDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI---K 208
E+ L K KA ++E ++ A + T+T+++ + + + + + Q++ K
Sbjct: 239 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 298
Query: 209 GAIEVLIREYSSELNA-----PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKED 263
I++ ++E +L P Q+ + KE + V+ + + E
Sbjct: 299 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-------VSAKLQAQVEENEL 351
Query: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERE 319
N + +++++ + R+ K ++ +K++E++ K +EK R++ EK RR+ E E+E
Sbjct: 352 WNRLNQQQEEK--MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 409
Query: 320 RERRERER---EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD-----RDR 371
+ R +E E+E + R++E E+E + ++ E+++ R++E R R++
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469
Query: 372 ERSSDRNKDRSRSREKSRDRERE-RERERERERERERERERERERERERERERE---REK 427
E+ ++ R EK R++E + RE+E + R+ E+ E+E+ RE E+ +E+E R++
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 428 DKKRDREE---DEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEE 484
+K R++EE +E +E+ + RK EK +E++ + E +K RE E++ R+EE
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE----EKIREQEEKVWRQEE 585
Query: 485 RRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELE 544
+ RE ++ + +E + + ++ + + G +K EK E +E+ R++E E
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE----E 641
Query: 545 EIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE--EEEEEKQEKEEKREEPME 602
+IR++ E + EQE + R Q ++ QE E + E+EE+ E+EEK +E E
Sbjct: 642 KIREQ-----------EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 603 EEEEPEQK 610
+ E+K
Sbjct: 691 KMRRQEEK 698
Score = 130 bits (326), Expect = 7e-30
Identities = 113/471 (23%), Positives = 240/471 (50%), Gaps = 49/471 (10%)
Query: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQM-IKGAIEVLIREYSSELNAPSQE 228
D WK + + T + ++E TK RD + ++ + E E NA QE
Sbjct: 230 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 289
Query: 229 SDSHPRKKKKEKK---EDIFRRFPVAPLI--PYPLITKEDINAIEMEEDKRDLISR--EI 281
+K E + +++ R+ A L+ L + D E++ L ++ E
Sbjct: 290 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 349
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341
+ +++ EE+ ++E++ QE E++ +E+E E+ RE+ E+ RE+E + R++E
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQEEMMW 406
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER-ERERE 400
E+E + R + E++ R+ + ++E +++ +EK R++E +R E E+
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 466
Query: 401 RERERERERERERERERERERERE---REKDKKRDREEDEEDAYERRKLERKLREKEAAY 457
RE+E+ +E+E + R+ E+ RE+E RE+++K R+E++ E+ + E K +E+E +
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW 526
Query: 458 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517
++ K IRE+++ +++ +EE+ R+ ++ R +E + D ++
Sbjct: 527 RQEEK---IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEE------------ 571
Query: 518 LQKRLRDREKEM--------EADERDRK-----REKEELEEIRQRLLAEGHPDPDAELQR 564
++R++E+++ E +E+ R+ RE+EE+ + ++ + E + ++
Sbjct: 572 ---KIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628
Query: 565 MEQEAERRRQPQIK---QEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPC 612
M+++ E+ R+ + K QE + E+EE+ +E+EE +E E+ E E+K C
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Score = 127 bits (319), Expect = 4e-29
Identities = 105/445 (23%), Positives = 222/445 (49%), Gaps = 58/445 (13%)
Query: 156 KLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLI 215
K L V AK +AQ++E + + + + E + +E+ + E K ++Q E I
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEEKIQEQ------EEKI 384
Query: 216 REYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRD 275
RE ++ QE +++ +KE+ RR + +++ E EE R+
Sbjct: 385 REQEEKIR--EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 442
Query: 276 LISR--EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERER 333
L + E K R+ +K +EE+ +E+E+++ ++ + R+ E+ RE+E + RE+E + R
Sbjct: 443 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWR 502
Query: 334 EREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRER 393
+ EK E+E+ RE ++ R ++ + R E+ R+++ + R +EK ++E
Sbjct: 503 QEEKIHEQEKIREEEK---RQEQEEMWRQEEKIREQE---------EIWRQKEKIHEQEE 550
Query: 394 EREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREK 453
+ ++ E+ +E + + E+ RE+E + R+++K R++EE + R+ E K+RE+
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE------KIREQEEKIREQ 604
Query: 454 EAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY 513
E QE+ + +E K + EK E+EE+ RR+ K ++
Sbjct: 605 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ------------------ 646
Query: 514 RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRR 573
+K++R++E+++ E + ++E++ E +++ + + ++Q E++ R+
Sbjct: 647 -----EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC-----EQEEKMQEQEEKMRRQE 696
Query: 574 QPQIKQEPESEEEEEEKQEKEEKRE 598
+ +QE ++EE+ QE +E E
Sbjct: 697 EKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 120 bits (302), Expect = 4e-27
Identities = 119/514 (23%), Positives = 242/514 (47%), Gaps = 94/514 (18%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNA----PSQESD 230
KKK N PET T+ + ++E K Q E L RE ++++ Q+++
Sbjct: 147 KKKKINNGTNPETTTSGGCHSPEDEQKASHQ----HQEALRRELEAQVHTIRILTCQKTE 202
Query: 231 --------SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
H K+ + + D+ R + L ++ ++A+ ++ K D E++
Sbjct: 203 LQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELT 260
Query: 283 KFRD-----------THKKLEEEKGKKEKERQEIEKERRE-----RERERERER------ 320
K RD T ++L+E+ K +++ Q +E E+ E +E +R+ ER
Sbjct: 261 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 320
Query: 321 --------------------------------ERREREREREREREREKEKERERERERD 348
R +++E + R+ EK +E E + +
Sbjct: 321 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ 380
Query: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE 408
++ R +E ++ R++E R E ++ + R E ++E + R+ E E+E +
Sbjct: 381 EEKIREQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 439
Query: 409 ----REREREREREREREREREKDKK-RDREEDEEDAYERRKLERKLREKEAAYQER-LK 462
E+ E+E+ RE+E +R++++K R++E+ +E + + E K+RE+E +E+ K
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499
Query: 463 NW----EIRERKKTREYEKEAEREEERRRE----MAKEAKRLKEFLEDYDDD--RDDPKY 512
W +I E++K RE EK E+EE R+E +E R KE + + ++ + + K
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKM 559
Query: 513 YRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR 572
+R ++++ D+E+++ E R++E++ E +++ + + E + M QE E +
Sbjct: 560 WR---QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ--EEKIREQEEMTQEQEEK 614
Query: 573 RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
Q ++ E EE+ +E++EK ++EE + E+E+
Sbjct: 615 MGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648
Score = 101 bits (252), Expect = 3e-21
Identities = 93/406 (22%), Positives = 199/406 (49%), Gaps = 38/406 (9%)
Query: 117 KRVQGASGKLQA-------FGFCEYKEPESTLRALRLLHDLQ--IGEKKLLVKVDAKTKA 167
K +Q S KLQA + ++ E R + + + I E++ ++ + + K
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR-EQEEKI 391
Query: 168 QLDEWKAKKKASNGNARPETVTNDDEEALDEETK-RRDQMIKGAIEVLIREYSSELNAPS 226
+ E K +++ + E + +E ++E K RR + + E IRE +++
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451
Query: 227 QESDSHPRKKKKEK-KEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFR 285
+ + +++++EK +E R+ A + +E I +E+K + R+ K
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK---MWRQEEKIH 508
Query: 286 DTHKKLEEEKGKKEKERQEIEKERRE-----RERERERERERREREREREREREREK--- 337
+ K EEEK ++++E E++ RE R++E+ E+E + R++E + R+ EK
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 338 --EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
EK RE+E + R ++ +E++ + ++ R++E + +++ +E+ + E+
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628
Query: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
+E+E + R+ E+ RE+E++ + E+ RE+++ +E EE +E+ E K+ E+E
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM--MQEQEEKMWEQ---EEKMCEQEE 683
Query: 456 AYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE 501
QE + +K R E++ +E R R+ ++ + +E LE
Sbjct: 684 KMQE--------QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 137 bits (344), Expect = 5e-32
Identities = 116/487 (23%), Positives = 253/487 (51%), Gaps = 52/487 (10%)
Query: 154 EKKLLVKVDAKTKAQ--LDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI---K 208
E+ L K KA ++E ++ A + T+T+++ + + + + + Q++ K
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 237
Query: 209 GAIEVLIREYSSELNA-----PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKED 263
I++ ++E +L P Q+ + KE + V+ + + E
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-------VSAKLQAQVEENEL 290
Query: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERE 319
N + +++++ + R+ K ++ +K++E++ K +EK R++ EK RR+ E E+E
Sbjct: 291 WNRLNQQQEEK--MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 320 RERRERER---EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSD 376
+ R +E E+E + R +E E+E + ++ E+++ R++E R +E
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR---QEEEKI 405
Query: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREE- 435
R +++ + +E R+ E+ RE+E E+ RE+E++ R+ E+ E+E+ RE++K++++EE
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 436 --DEEDAYERRKLER---KLREKEAAYQERLKNWEIRER-----KKTREYEKEAEREEER 485
EE E+ ++ R K+ E+E ++ K W E+ +K RE E++ R+EE+
Sbjct: 465 WRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524
Query: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE 545
RE ++ + +E + + ++ + ++++ ++E++M+ E+ R R++E++ E
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQEQ--------EEKMGEQEEKMQEQEKMR-RQEEKIRE 575
Query: 546 IRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE--EEEEEKQEKEEKREEPMEE 603
+++ + + E + EQE + R Q ++ QE E + E+EE+ E+EEK +E E+
Sbjct: 576 QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635
Query: 604 EEEPEQK 610
E+K
Sbjct: 636 MRRQEEK 642
Score = 135 bits (341), Expect = 1e-31
Identities = 111/458 (24%), Positives = 238/458 (51%), Gaps = 43/458 (9%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNAR-PETVTNDDEEALDEETKRRDQMIKGAIE 212
++KL + K++ QL+ + K+K P+ + + L +E + ++ +E
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 213 VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEED 272
E + LN +E +K +E +E I + +E I +E+
Sbjct: 287 E--NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI---------REQEEKIREQEE 335
Query: 273 KRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERE-RERERERRERERERER 331
K + + + ++ EE +KE++ + +E+ E+E + RE E + E+E+ RE+
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395
Query: 332 ERER-EKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
E +R E+EK RE+E+ ++++ ++ ++ R++E ++ R++E+ R +++ +EK R+
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 391 RERERERERERERERERERERE---REREREREREREREKDKKRDREEDEEDAYERRKLE 447
E+ +E+E E R+ E+ RE+E R++E+ E+E+ R++++K R+E++ E
Sbjct: 455 EEKRQEQE-EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK-----MHDQE 508
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
K+RE+E K W R+ +K RE E++ +EE+ RE + + +E + + ++
Sbjct: 509 EKIREQEE------KMW--RQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
+ Q+++R +E+++ E + +KE++ E +++ + + E + M Q
Sbjct: 561 QE---------QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ--EEKIREQEEMMQ 609
Query: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEE 605
E E + Q ++ E EE+ +E++EK ++EE M E+E
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Score = 131 bits (330), Expect = 2e-30
Identities = 119/471 (25%), Positives = 240/471 (50%), Gaps = 44/471 (9%)
Query: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQM-IKGAIEVLIREYSSELNAPSQE 228
D WK + + T + ++E TK RD + ++ + E E NA QE
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 229 SDSHPRKKKKEKK---EDIFRRFPVAPLI--PYPLITKEDINAIEMEEDKRDLISR--EI 281
+K E + +++ R+ A L+ L + D E++ L ++ E
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341
+ +++ EE+ ++E++ QE E++ +E+E E+ RE+ E+ RE+E + R++E
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQEEMMW 345
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER-ERERE 400
E+E + R + E++ R + ++E +++ +EK R++E +R E E+
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405
Query: 401 RERERERERERERERERERERERE---REKDKKRDREEDEEDAYERRKLERKLREKEAAY 457
RE+E+ +E+E + R+ E+ RE+E RE++KK R+E++ E+ + E K +E+E +
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 465
Query: 458 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517
++ K IRE+++ +KE E+E+ R+ ++ R +E + D ++ + +
Sbjct: 466 RQEEK---IREQEEIWR-QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE------ 515
Query: 518 LQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ- 576
+K R EK E +E+ R++E++ E+ + ++ E + ++M+++ + RRQ +
Sbjct: 516 -EKMWRQEEKIREQEEKIREQEEKIREQ--EEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 577 -------IKQEPESEEEEEEK----QEKEEKREEPMEEEE----EPEQKPC 612
I+++ E E+EEK +EK ++EE M+E+E E E+K C
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMC 623
Score = 122 bits (305), Expect = 2e-27
Identities = 124/518 (23%), Positives = 238/518 (45%), Gaps = 92/518 (17%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNA----PSQESD 230
KKK N PET T+ + ++E K Q E L RE ++++ Q+++
Sbjct: 86 KKKKINNGTNPETTTSGGCHSPEDEQKASHQ----HQEALRRELEAQVHTIRILTCQKTE 141
Query: 231 --------SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
H K+ + + D+ R + L ++ ++A+ ++ K D E++
Sbjct: 142 LQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELT 199
Query: 283 KFRD-----------THKKLEEEKGKKEKERQEIEKERRE-----RERERERER------ 320
K RD T ++L+E+ K +++ Q +E E+ E +E +R+ ER
Sbjct: 200 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 259
Query: 321 --------------------------------ERREREREREREREREKEKERERERERD 348
R +++E + R+ EK +E E + +
Sbjct: 260 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ 319
Query: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE 408
++ R +E ++ R++E R E ++ + R E ++E + R E E+E +
Sbjct: 320 EEKIREQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEK 378
Query: 409 ----REREREREREREREREREKDKK-RDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
E+ E+E+ RE+E +R++++K R++E+ +E + + E K+RE+E +E+ K
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 438
Query: 464 -W----EIRERKKTREYEKEAEREEERRRE----MAKEAKRLKEFLEDYDDDR-DDPKYY 513
W +I E++K RE EK E+EE R+E +E R KE + + + R + K +
Sbjct: 439 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVW 498
Query: 514 RGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRR 573
R ++++ D+E+++ E R++E++ E +++ + + E EQE +
Sbjct: 499 R---QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE 555
Query: 574 QPQIKQEPESEEEEEEK-QEKEEKREEPMEEEEEPEQK 610
Q + QE E +EEK +E+EEK E E+ E E+K
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Score = 98.2 bits (243), Expect = 3e-20
Identities = 95/415 (22%), Positives = 204/415 (49%), Gaps = 51/415 (12%)
Query: 117 KRVQGASGKLQA-------FGFCEYKEPESTLRALRLLHDLQ--IGEKKLLVKVDAKTKA 167
K +Q S KLQA + ++ E R + + + I E++ ++ + + K
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR-EQEEKI 330
Query: 168 QLDEWKAKKKASNGNARPETVTNDDEEALDEETK-RRDQMIKGAIEVLIREYSSELNAPS 226
+ E K +++ + E + +E ++E K RR + + E IRE +++
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 227 QESDSHPRKKKKEK-KEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFR 285
+ + +++++EK +E R+ A + +++ E EE R+ +E +R
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKM------WRQEEKIREQEEKIRE---QEKKMWR 441
Query: 286 DTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERER 345
K E+EK ++E++RQE E+ R+ E+ RE+E R++E+ E+E+ R++E++ R+
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE 501
Query: 346 ERDRDRD-RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE---------- 394
E+ D++ + +E++ R+ ++ R++E +++ R +E+ + E
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 395 ------REREREREREREREREREREREREREREREREKDKKRDR--EEDEEDAYERRKL 446
R+ E+ RE+E + ++E+ RE+E + + EK ++++ +E EE +E+
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQ--- 618
Query: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE 501
E K+ E+E QE + +K R E++ +E R R+ ++ + +E LE
Sbjct: 619 EEKMCEQEEKMQE--------QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 84.7 bits (208), Expect = 3e-16
Identities = 63/275 (22%), Positives = 138/275 (50%), Gaps = 18/275 (6%)
Query: 184 RPETVTNDDEEALDEETKRRDQMIK-GAIEVLIREYSSELNAPS-----QESDSHPRKK- 236
R + +EE + E+ KR++Q K E IRE ++ QE H ++K
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 237 ----KKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLE 292
K++++E+++R+ KE ++ E + + + R+ K D +K+
Sbjct: 453 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIR 512
Query: 293 EEKGK----KEKERQEIEKERRERERERERERERREREREREREREREKEKERERERE-- 346
E++ K +EK R++ EK R + E+ RE+E +E+E + + E+ +E+E+ R +E
Sbjct: 513 EQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 347 -RDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERER 405
R+++ +++++ R++E E+ ++ + EK ++E + + E+ +E+
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 406 EREREREREREREREREREREKDKKRDREEDEEDA 440
E + R+ E+ E+E ++++K ++ +E E A
Sbjct: 633 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 135 bits (341), Expect = 1e-31
Identities = 102/333 (30%), Positives = 157/333 (47%), Gaps = 57/333 (17%)
Query: 310 RERERERERERER-REREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD 368
RE R+R R R R R R ++ K + R R RDRDR +ER R RD+ R R
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62
Query: 369 RDRER---SSDRNKDRSRSREKSRDRERERERERERERE-------------RERERERE 412
RDR+R S R +DRSR R +SR R+R R R R R R R R +E
Sbjct: 63 RDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKE 122
Query: 413 REREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKT 472
+ E +E++++KD K D +E + +++ KLE ++R+++ ER++ W +RKK
Sbjct: 123 KTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRK----ERVEKWREEQRKKA 178
Query: 473 REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
E E ++E E ++ K + LED DDD DDP + +K + E E E D
Sbjct: 179 MENIGELKKEIEEMKQGKKWS------LEDDDDDEDDP-----AEAEKEGNEMEGE-ELD 226
Query: 533 ERDRKRE--KEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI----------KQE 580
D E KEE+++ R + G + E++ P + K
Sbjct: 227 PLDAYMEEVKEEVKKFNMRSVKGGGGN------------EKKSGPTVTKVVTVVTTKKAV 274
Query: 581 PESEEEEEEKQEKEEKREEPMEEEEEPEQKPCL 613
+S++++ E E ++ E EEEE + + L
Sbjct: 275 VDSDKKKGELMENDQDAMEYSSEEEEVDLQTAL 307
Score = 94.4 bits (233), Expect = 4e-19
Identities = 74/279 (26%), Positives = 121/279 (43%), Gaps = 25/279 (8%)
Query: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERE 414
+E R R R R RS R+ RS+ R R R+R+R RER R R++ R R
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62
Query: 415 RERER-EREREREKDKKRDREED-EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKT 472
R+R+R R R RE+D+ R+R D R R R + ++ + K E R R K
Sbjct: 63 RDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKE 122
Query: 473 REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
+ E+ +E+++ D DD D+ + G+ Q +L E+EM
Sbjct: 123 KTDGGESSKEKKK----------------DKDDKEDEKEKDAGNFDQNKL---EEEM--- 160
Query: 533 ERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE 592
R RK E+ E +++ E + E++ M+Q + + E + E E+E E
Sbjct: 161 -RKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNE 219
Query: 593 KEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASG 631
E + +P++ E ++ K +R + SG
Sbjct: 220 MEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSG 258
Score = 85.9 bits (211), Expect = 1e-16
Identities = 55/208 (26%), Positives = 105/208 (50%), Gaps = 16/208 (7%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
+ KR R S+ RD ++ + K+ ++ ++ RR R RER+R RERR R R R
Sbjct: 30 KRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERR-RSRSR 88
Query: 330 EREREREKEKERE-------RERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRS 382
+R R R + + R + ++ +R R+KE+ + +++ +D++ D + +
Sbjct: 89 DRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDA 148
Query: 383 RSREKSRDREREREREREREREREREREREREREREREREREREKDKKR----DREEDEE 438
+ ++++ E R+R+ E+ RE +R++ E E ++E E K K+ D ++DE+
Sbjct: 149 GNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDED 208
Query: 439 DAYERRKLERKLREKEA----AYQERLK 462
D E K ++ +E AY E +K
Sbjct: 209 DPAEAEKEGNEMEGEELDPLDAYMEEVK 236
Score = 30.4 bits (67), Expect = 7.2
Identities = 40/192 (20%), Positives = 76/192 (39%), Gaps = 29/192 (15%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPR 234
+K+ +R + + + + +R +G R SS S+++++ R
Sbjct: 65 RKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGR-----RSRSSSPGNKSKKTENRSR 119
Query: 235 KKKK--------EKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRD 286
K+K EKK+D KED + ++ + E+ K ++
Sbjct: 120 SKEKTDGGESSKEKKKD--------------KDDKEDEKEKDAGNFDQNKLEEEMRKRKE 165
Query: 287 THKKLEEEKGKKEKER-QEIEKERRERERERERERERRERERERERERERE-KEKERERE 344
+K EE+ KK E E++KE E ++ ++ E + + + E E+E E E E
Sbjct: 166 RVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEEL 225
Query: 345 RERDRDRDRTKE 356
D + KE
Sbjct: 226 DPLDAYMEEVKE 237
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 135 bits (339), Expect = 2e-31
Identities = 72/180 (40%), Positives = 109/180 (60%), Gaps = 3/180 (1%)
Query: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336
I + + ++ +K EE + E+ ++E ++ER ERE+ERERERE RER+R RE E ERE
Sbjct: 223 IKATVEELKEKLRKRTEEPDRDERLKKE-KQEREEREKEREREREERERKRRRE-EEERE 280
Query: 337 KEKERERE-RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
KE+ R+RE R+R R R R R DR R RD R RS +R + RSR R +SR +R
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
+ R R R+R R + R+R+ + R + R+RE+D+K +E ++ ++ REK++
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Score = 132 bits (331), Expect = 2e-30
Identities = 77/228 (33%), Positives = 120/228 (52%), Gaps = 16/228 (7%)
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341
+K + T ++L+E+ K+ +E E+ ++E++ ERE+ER ERER+R RE E+ER
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE-EEER 279
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
E+ER RDR+R R + R R R R DR RS D + RSR R +SR R+R R R +R
Sbjct: 280 EKERARDRER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
Query: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
+ R R R+R R + R+R+ + + K RDRE+D RK +EKE +
Sbjct: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQD-----------RKSKEKEKRGSDDK 387
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509
K+ + +RE + E E + + E E ++ D + +
Sbjct: 388 KS---SVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 125 bits (315), Expect = 1e-28
Identities = 71/184 (38%), Positives = 107/184 (58%), Gaps = 9/184 (4%)
Query: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
+EE K L R RD ++L++EK ++E+ +E E+ER ERER+R RE E RE+ER
Sbjct: 227 VEELKEKLRKRTEEPDRD--ERLKKEKQEREEREKEREREREERERKRRREEEEREKERA 284
Query: 329 RERERE-----REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN--KDR 381
R+RER R + R +R R RD + R R+R R R RDR R RS DR+ K R
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441
SRSR++ R + R+R+ + R + R+RE++R+ + + +R + ++ K RE+ ED
Sbjct: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Query: 442 ERRK 445
K
Sbjct: 405 TESK 408
Score = 107 bits (266), Expect = 6e-23
Identities = 94/382 (24%), Positives = 165/382 (43%), Gaps = 70/382 (18%)
Query: 68 RKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQ 127
R+ H L +N ++ G G EK I+ L K ++L G+ GK++
Sbjct: 101 RRGHARLALSQNQQSSGAAGPT--GKNEEK-----IQVLTDKIDVLLQQIEELGSEGKVE 153
Query: 128 AFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN--GNARP 185
E + ++ + L + E++LL T + ++ + A++K
Sbjct: 154 --------EAQGMMKLVEQLKE----ERELL----RSTTSTIESFAAQEKQMEVCEVCGA 197
Query: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPR-KKKKEKKEDI 244
+ D + +D+ + M I+ + E +L ++E D R KK+K+++E+
Sbjct: 198 FLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE- 256
Query: 245 FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
+E E EE R+ ++ EEE+ +KE+ R
Sbjct: 257 ----------------REKEREREREE-------------RERKRRREEEEREKERAR-- 285
Query: 305 IEKERRERERERERERER-------REREREREREREREKEKERERERERDRDRDRTKER 357
++ERR+R R R R R R R+ +R R RER + + R+R R R DR K R
Sbjct: 286 -DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
R RDR R + RDR+ K RS+SR++ +DR+ + + +R + ++ + RE++
Sbjct: 345 SRSRDRRRSKSRDRK----SYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 418 EREREREREKDKKRDREEDEED 439
E +E D K + ED
Sbjct: 401 EDTNTESKESDTKNEVNGTSED 422
Score = 87.8 bits (216), Expect = 4e-17
Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 10/209 (4%)
Query: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
+ K R R+ E RD ++E++ ERE+ERERERE + R E EREK++ RDRE
Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE-- 288
Query: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
RRK R R + ++ + R+ K++R E+ R +RRR + +
Sbjct: 289 ------RRKRSRS-RSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER 341
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
K D R + + + + RDRE++ ++ E++++ ++ ++ +
Sbjct: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 557 DPDAELQRMEQEAE-RRRQPQIKQEPESE 584
D + E + + + E IK E +++
Sbjct: 402 DTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
Score = 87.4 bits (215), Expect = 5e-17
Identities = 64/203 (31%), Positives = 105/203 (51%), Gaps = 15/203 (7%)
Query: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER 423
E +++ R+R+ + ++D +EK ERE+ERERERE ERER+R RE E ERE+ER R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRRE-EEEREKERAR 285
Query: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE----KEA 479
+RE+ K+ R+ R K + +ER ++ R+R+++R ++ K
Sbjct: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRS-RSRDRRRSRSHDRSERKHR 344
Query: 480 EREEERRREMAKEAKRLKEFLEDYDDDRD---DPKYYRGSALQK---RLRDREKEMEADE 533
R +RRR +++ K K + D ++D K RGS +K + REK+ E
Sbjct: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Query: 534 RDRKRE--KEELEEIRQRLLAEG 554
+ K K E+ + + +EG
Sbjct: 405 TESKESDTKNEVNGTSEDIKSEG 427
Score = 68.2 bits (165), Expect = 3e-11
Identities = 56/209 (26%), Positives = 99/209 (47%), Gaps = 29/209 (13%)
Query: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAY 457
E +E+ R+R E +R+ ER ++ ++ERE +++++RE + E+ +R+ E + REKE A
Sbjct: 228 EELKEKLRKRTEEPDRD-ERLKKEKQERE-EREKEREREREERERKRRREEEEREKERAR 285
Query: 458 -QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
+ER K R R +R ++ R + +R ++E +R + DR + + S
Sbjct: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR------SRDRRRSRSHDRS 339
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
+ R R R++ + RDRK K + D E R +E E+R
Sbjct: 340 ERKHRSRSRDRR-RSKSRDRKSYKHRSK------------SRDREQDRKSKEKEKRGSDD 386
Query: 577 IK-------QEPESEEEEEEKQEKEEKRE 598
K +E +SE+ E +E + K E
Sbjct: 387 KKSSVKSGSREKQSEDTNTESKESDTKNE 415
Score = 62.4 bits (150), Expect = 2e-09
Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 11/210 (5%)
Query: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
E K+K R R E E D ER K E+ +E+E +ER + E RERK+ RE E+E E+E
Sbjct: 228 EELKEKLRKRTE-EPDRDERLKKEK--QEREEREKEREREREERERKRRRE-EEEREKER 283
Query: 484 ERRREMAKEAKRLKEFLEDYDD-----DRDDPKYYRGSALQKRLRDREKEMEADERDRKR 538
R RE K ++ D RD + + R RDR + D +RK
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
Query: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE 598
+ R+R + + ++E +R+ + + K+ + ++ + +E++ E
Sbjct: 344 RSRSRD--RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 599 EPMEEEEEPEQKPCLKPTLRPISSAPSVSS 628
+ E +E + K + T I S S
Sbjct: 402 DTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
Score = 37.4 bits (85), Expect = 0.059
Identities = 35/161 (21%), Positives = 70/161 (43%), Gaps = 13/161 (8%)
Query: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREE-ERRREMAKEAKRLKEFLEDYDDDR 507
K++ +E+L+ + R +++ EREE E+ RE +E + K E+ + ++
Sbjct: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREK 281
Query: 508 DDPKYYRGSALQKRLRDREKEMEAD-----ERDRKREK-EELEEIRQRLLAEGHPDPDAE 561
+ + R + R R R +D RD KR + E R R +E
Sbjct: 282 ERAR-DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 562 LQRMEQEAERRR-----QPQIKQEPESEEEEEEKQEKEEKR 597
+ + +RRR + K +S + E++++ KE+++
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK 381
Score = 33.9 bits (76), Expect = 0.65
Identities = 15/51 (29%), Positives = 31/51 (60%)
Query: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
A+++ +E + + + + ++ E ++EKQE+EE+ +E E EE E+K
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERK 271
Score = 32.0 bits (71), Expect = 2.5
Identities = 17/63 (26%), Positives = 36/63 (57%), Gaps = 3/63 (4%)
Query: 540 KEELEEIRQRLLAEGH-PDPDAELQRMEQEAERRRQPQIKQEPESEEEE--EEKQEKEEK 596
K +EE++++L PD D L++ +QE E R + + ++ E E + EE++ ++E+
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 597 REE 599
+
Sbjct: 284 ARD 286
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 135 bits (339), Expect = 2e-31
Identities = 72/180 (40%), Positives = 109/180 (60%), Gaps = 3/180 (1%)
Query: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336
I + + ++ +K EE + E+ ++E ++ER ERE+ERERERE RER+R RE E ERE
Sbjct: 223 IKATVEELKEKLRKRTEEPDRDERLKKE-KQEREEREKEREREREERERKRRRE-EEERE 280
Query: 337 KEKERERE-RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
KE+ R+RE R+R R R R R DR R RD R RS +R + RSR R +SR +R
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
+ R R R+R R + R+R+ + R + R+RE+D+K +E ++ ++ REK++
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Score = 132 bits (331), Expect = 2e-30
Identities = 77/228 (33%), Positives = 120/228 (52%), Gaps = 16/228 (7%)
Query: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341
+K + T ++L+E+ K+ +E E+ ++E++ ERE+ER ERER+R RE E+ER
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE-EEER 279
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
E+ER RDR+R R + R R R R DR RS D + RSR R +SR R+R R R +R
Sbjct: 280 EKERARDRER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
Query: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
+ R R R+R R + R+R+ + + K RDRE+D RK +EKE +
Sbjct: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQD-----------RKSKEKEKRGSDDK 387
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509
K+ + +RE + E E + + E E ++ D + +
Sbjct: 388 KS---SVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 125 bits (315), Expect = 1e-28
Identities = 71/184 (38%), Positives = 107/184 (58%), Gaps = 9/184 (4%)
Query: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
+EE K L R RD ++L++EK ++E+ +E E+ER ERER+R RE E RE+ER
Sbjct: 227 VEELKEKLRKRTEEPDRD--ERLKKEKQEREEREKEREREREERERKRRREEEEREKERA 284
Query: 329 RERERE-----REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN--KDR 381
R+RER R + R +R R RD + R R+R R R RDR R RS DR+ K R
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441
SRSR++ R + R+R+ + R + R+RE++R+ + + +R + ++ K RE+ ED
Sbjct: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Query: 442 ERRK 445
K
Sbjct: 405 TESK 408
Score = 107 bits (266), Expect = 6e-23
Identities = 94/382 (24%), Positives = 165/382 (43%), Gaps = 70/382 (18%)
Query: 68 RKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQ 127
R+ H L +N ++ G G EK I+ L K ++L G+ GK++
Sbjct: 101 RRGHARLALSQNQQSSGAAGPT--GKNEEK-----IQVLTDKIDVLLQQIEELGSEGKVE 153
Query: 128 AFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN--GNARP 185
E + ++ + L + E++LL T + ++ + A++K
Sbjct: 154 --------EAQGMMKLVEQLKE----ERELL----RSTTSTIESFAAQEKQMEVCEVCGA 197
Query: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPR-KKKKEKKEDI 244
+ D + +D+ + M I+ + E +L ++E D R KK+K+++E+
Sbjct: 198 FLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE- 256
Query: 245 FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
+E E EE R+ ++ EEE+ +KE+ R
Sbjct: 257 ----------------REKEREREREE-------------RERKRRREEEEREKERAR-- 285
Query: 305 IEKERRERERERERERER-------REREREREREREREKEKERERERERDRDRDRTKER 357
++ERR+R R R R R R R+ +R R RER + + R+R R R DR K R
Sbjct: 286 -DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
R RDR R + RDR+ K RS+SR++ +DR+ + + +R + ++ + RE++
Sbjct: 345 SRSRDRRRSKSRDRK----SYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 418 EREREREREKDKKRDREEDEED 439
E +E D K + ED
Sbjct: 401 EDTNTESKESDTKNEVNGTSED 422
Score = 87.8 bits (216), Expect = 4e-17
Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 10/209 (4%)
Query: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
+ K R R+ E RD ++E++ ERE+ERERERE + R E EREK++ RDRE
Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE-- 288
Query: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
RRK R R + ++ + R+ K++R E+ R +RRR + +
Sbjct: 289 ------RRKRSRS-RSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER 341
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
K D R + + + + RDRE++ ++ E++++ ++ ++ +
Sbjct: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 557 DPDAELQRMEQEAE-RRRQPQIKQEPESE 584
D + E + + + E IK E +++
Sbjct: 402 DTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
Score = 87.4 bits (215), Expect = 5e-17
Identities = 64/203 (31%), Positives = 105/203 (51%), Gaps = 15/203 (7%)
Query: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER 423
E +++ R+R+ + ++D +EK ERE+ERERERE ERER+R RE E ERE+ER R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRRE-EEEREKERAR 285
Query: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE----KEA 479
+RE+ K+ R+ R K + +ER ++ R+R+++R ++ K
Sbjct: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRS-RSRDRRRSRSHDRSERKHR 344
Query: 480 EREEERRREMAKEAKRLKEFLEDYDDDRD---DPKYYRGSALQK---RLRDREKEMEADE 533
R +RRR +++ K K + D ++D K RGS +K + REK+ E
Sbjct: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
Query: 534 RDRKRE--KEELEEIRQRLLAEG 554
+ K K E+ + + +EG
Sbjct: 405 TESKESDTKNEVNGTSEDIKSEG 427
Score = 68.2 bits (165), Expect = 3e-11
Identities = 56/209 (26%), Positives = 99/209 (47%), Gaps = 29/209 (13%)
Query: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAY 457
E +E+ R+R E +R+ ER ++ ++ERE +++++RE + E+ +R+ E + REKE A
Sbjct: 228 EELKEKLRKRTEEPDRD-ERLKKEKQERE-EREKEREREREERERKRRREEEEREKERAR 285
Query: 458 -QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
+ER K R R +R ++ R + +R ++E +R + DR + + S
Sbjct: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR------SRDRRRSRSHDRS 339
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
+ R R R++ + RDRK K + D E R +E E+R
Sbjct: 340 ERKHRSRSRDRR-RSKSRDRKSYKHRSK------------SRDREQDRKSKEKEKRGSDD 386
Query: 577 IK-------QEPESEEEEEEKQEKEEKRE 598
K +E +SE+ E +E + K E
Sbjct: 387 KKSSVKSGSREKQSEDTNTESKESDTKNE 415
Score = 62.4 bits (150), Expect = 2e-09
Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 11/210 (5%)
Query: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
E K+K R R E E D ER K E+ +E+E +ER + E RERK+ RE E+E E+E
Sbjct: 228 EELKEKLRKRTE-EPDRDERLKKEK--QEREEREKEREREREERERKRRRE-EEEREKER 283
Query: 484 ERRREMAKEAKRLKEFLEDYDD-----DRDDPKYYRGSALQKRLRDREKEMEADERDRKR 538
R RE K ++ D RD + + R RDR + D +RK
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
Query: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE 598
+ R+R + + ++E +R+ + + K+ + ++ + +E++ E
Sbjct: 344 RSRSRD--RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 599 EPMEEEEEPEQKPCLKPTLRPISSAPSVSS 628
+ E +E + K + T I S S
Sbjct: 402 DTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
Score = 37.4 bits (85), Expect = 0.059
Identities = 35/161 (21%), Positives = 70/161 (43%), Gaps = 13/161 (8%)
Query: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREE-ERRREMAKEAKRLKEFLEDYDDDR 507
K++ +E+L+ + R +++ EREE E+ RE +E + K E+ + ++
Sbjct: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREK 281
Query: 508 DDPKYYRGSALQKRLRDREKEMEAD-----ERDRKREK-EELEEIRQRLLAEGHPDPDAE 561
+ + R + R R R +D RD KR + E R R +E
Sbjct: 282 ERAR-DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
Query: 562 LQRMEQEAERRR-----QPQIKQEPESEEEEEEKQEKEEKR 597
+ + +RRR + K +S + E++++ KE+++
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK 381
Score = 33.9 bits (76), Expect = 0.65
Identities = 15/51 (29%), Positives = 31/51 (60%)
Query: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
A+++ +E + + + + ++ E ++EKQE+EE+ +E E EE E+K
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERK 271
Score = 32.0 bits (71), Expect = 2.5
Identities = 17/63 (26%), Positives = 36/63 (57%), Gaps = 3/63 (4%)
Query: 540 KEELEEIRQRLLAEGH-PDPDAELQRMEQEAERRRQPQIKQEPESEEEE--EEKQEKEEK 596
K +EE++++L PD D L++ +QE E R + + ++ E E + EE++ ++E+
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 597 REE 599
+
Sbjct: 284 ARD 286
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 133 bits (334), Expect = 8e-31
Identities = 117/467 (25%), Positives = 217/467 (46%), Gaps = 69/467 (14%)
Query: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
K+ +K +A + ++E +EE +R + + +EV++ E ++E SQE
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE----SQEE--- 222
Query: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLE 292
V + I+ E+ +E++R+ S EIS H+K+E
Sbjct: 223 ----------------TVVMSLKNGQISSEE----PKQEEEREQGSDEISH----HEKME 258
Query: 293 EEKGKKEKERQEIEKERRE-RERERERERERREREREREREREREKEKERERERERDRDR 351
EE +KER E E+ R E ERER + + ++ ER R EK +ERER +R
Sbjct: 259 EE----DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Query: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERER 411
+R +E ++ ER R ++ E+ + + R + EK ER+R +E E+ ER+R R
Sbjct: 315 ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
Query: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREK----EAAYQERL------ 461
E E+ + E++R K + + +E + K+E+K+ K + A +++L
Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
Query: 462 -----KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR---DDPKYY 513
K +++ +++ + +K ++EE + E K+ K KE ++ + D + + K
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 514 RGSALQKRLRDREKEM------------EADERDRKREKEELEEIRQRLLAEGHPDPDAE 561
G + +L+ E EA+ + + LEE+R+R E + +
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR-RGETESEEFEK 553
Query: 562 LQRMEQEAERRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEE 606
L++ +QEA + K+ E + EEEE++ K+E+ + + EEEE
Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
Score = 114 bits (284), Expect = 5e-25
Identities = 102/463 (22%), Positives = 206/463 (44%), Gaps = 62/463 (13%)
Query: 160 KVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYS 219
+V+ + + + +AK +N V DDE A E RR++ + ++ +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQ-----VEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 220 --------SELNAPSQ----ESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAI 267
+ L+ PS+ ++ + +K+EK E R+ + E+ +
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI-----------EETETV 168
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
K D E +K D K+ EEE+ K E + E E+ E + E
Sbjct: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
Query: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
+ + E ++E ERE+ D K + D++R + +R R + +R + ++ +K
Sbjct: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA-EAERARLEAEERERIKAEQDKK 287
Query: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
D ER R E+ +ERER ERER RE E+ ++++R +EE++ A ER++++
Sbjct: 288 IAD-ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
+ EK AA ER++ +E EK A E +R R +E +++E
Sbjct: 347 EE--EKRAA----------EERQRIKEEEKRAAEERQRARAEEEEKAKVEE--------- 385
Query: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
QKR + E++ A + + + ++ ++I + + E D + +
Sbjct: 386 -----------QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
Query: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
+ + +++ + E +E++ +KEE ++E +++++EP+++
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477
Score = 93.6 bits (231), Expect = 7e-19
Identities = 93/390 (23%), Positives = 169/390 (43%), Gaps = 67/390 (17%)
Query: 286 DTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERER 345
D ++ E + K+E+ R E E+ +R + E E R ER R +ER R+K++E +
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAAR-ERRRRARQERLRQKQEEESLGQ 61
Query: 346 ERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK--DRSRSREKSRDRERERERERERE- 402
D+ + D + + + D +R RE+ R + + ER++E
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 403 -------------------------RERERERERERERERERERE-----------RERE 426
E+E + E +ER E E R+ E
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 427 KDKKRDREEDEEDAYERRK-------LERKLREKEAAYQER-----LKNWEIRERKKTRE 474
++KK D+E++EE+ + ++ +E + EK QE LKN +I + +E
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241
Query: 475 YEKEA--------EREEERRREMAK-EAKRL----KEFLEDYDDDRDDPKYYRGSALQKR 521
E+E E+ EE +E A+ E RL +E ++ D + + R A +K
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301
Query: 522 LRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER--RRQPQIKQ 579
+ EA+ER+R RE+E+ ++ + E E QR+++E +R + +IK+
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
Query: 580 EPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
E + EE ++ EE+ + +EE++ +Q
Sbjct: 362 EEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391
Score = 92.4 bits (228), Expect = 2e-18
Identities = 95/381 (24%), Positives = 180/381 (47%), Gaps = 50/381 (13%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
++E + ++ + E +K T+ ++E + E +E+ R ER ++R +E ER++
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDD-----EAAFLERLARREERRQKRLQEALERQK 119
Query: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSS---DRNKDRSRS 384
E + R + D + T E++ + ++R E + K+ R
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
Query: 385 REKSRDRERERERERERERER-------------ERERERERE-------------RERE 418
E+++ ++E+E E E + +R E+ E + E E +
Sbjct: 180 AEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 419 REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK---NWEIRERKKTREY 475
+E ERE+ D+ E+ EE+ ER + ER EA +ER+K + +I + + E
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAER--ARLEAEERERIKAEQDKKIADERARIEA 297
Query: 476 EKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME-ADER 534
E++A +E RRE A+E +R++E + ++R K A ++R R +E+E A+ER
Sbjct: 298 EEKAAAQERERRE-AEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
Query: 535 DR-KREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEK 593
R K E++ E RQR AE + E ++E E++R Q++++ + +E + K EK
Sbjct: 357 QRIKEEEKRAAEERQRARAE-----EEEKAKVE---EQKRNKQLEEKKHAMQETKIKGEK 408
Query: 594 EEKREEPMEEEEEPEQKPCLK 614
E++ E E+ Q+ L+
Sbjct: 409 VEQKIEGKWVNEKKAQEDKLQ 429
Score = 92.0 bits (227), Expect = 2e-18
Identities = 86/349 (24%), Positives = 152/349 (43%), Gaps = 41/349 (11%)
Query: 300 KERQEIEKERRERER-ERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
+ R+E+ +++RE R E ER +R + E E RER + +ER R++ + + D
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE-- 416
+ ++ D E + + +++ ER RE R++ + ER++E +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 417 --------REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN-WEIR 467
R + + +++ ++EE E ER ++E E E + KN W
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE----ETETVTKSYQKNDWRDA 180
Query: 468 ERKKTREYEKEAEREEERRR--------EMAKEAK-----------RLKEFLEDYDDDRD 508
E K + EKE E EE+ +R E+ E K LK ++ +
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 509 DPKYYRGSALQKRLRDREKEMEADERDRKREKEELE-EIRQRLLAEGHPDPDAELQRMEQ 567
+ + +GS + EK E D+ + E+ LE E R+R+ AE E R+E
Sbjct: 241 EEEREQGS---DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
Query: 568 EAERRRQPQIKQEPESEE--EEEEKQEKEEKREEPMEEEEEPEQKPCLK 614
E + Q + ++E E E EEEK+ EE++ EE+ E++ +K
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
Score = 73.2 bits (178), Expect = 1e-12
Identities = 81/382 (21%), Positives = 171/382 (44%), Gaps = 32/382 (8%)
Query: 149 DLQIGEKKLLVKVDAKTKAQ------LDEWKAKKKASNGNARPETVTNDDEEALDEETKR 202
D +I +++ ++ + K AQ +E + ++ A ++E+ EE +R
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
Query: 203 RDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKE 262
+ K A E R E A + + +++K K E+ R + +E
Sbjct: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL----------EE 394
Query: 263 DINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER 322
+A++ + K + + ++I KK +E+K + +++ E++ + + +RE+ +E
Sbjct: 395 KKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454
Query: 323 R---EREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
+ ++E ++ + +++KE + E + DR + T+ + ++ + + + E + R
Sbjct: 455 KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG 514
Query: 380 DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
R+ K + + E + E R R E E E E E+ K K+++ + E+
Sbjct: 515 GRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE-------EFEKLKQKQQEAALELEE 567
Query: 440 AYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
++R+ RK+ E+E E+ + E +RK E EK +EE RR KR K
Sbjct: 568 LKKKREERRKVLEEE----EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP 623
Query: 500 LEDYDDDRDDPKYY--RGSALQ 519
+ DD+ K + +GS+L+
Sbjct: 624 EDGLSDDKKPFKCFTPKGSSLK 645
Score = 68.6 bits (166), Expect = 2e-11
Identities = 91/409 (22%), Positives = 174/409 (42%), Gaps = 66/409 (16%)
Query: 152 IGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDE-----------EALDEET 200
IGE ++ V V+ KT +E NG E ++E E ++EE
Sbjct: 203 IGENQVEVMVEEKTTESQEE-TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEED 261
Query: 201 KRRDQMIKGAIEVLIRE----------------YSSELNAPSQESDSHPRKKKKEKKEDI 244
K R + + +E RE +E A +QE + ++++ +E+
Sbjct: 262 KERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEE 321
Query: 245 FRRFPVAPLIPYP---------LITKEDINAIE-----MEEDKRDLISREISKFRDTHK- 289
R I I +E+ A E EE+KR R+ ++ + K
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKA 381
Query: 290 KLEEEKGKKEKERQE-------IEKERRERERERERERERRERERERE----REREREKE 338
K+EE+K K+ E ++ I+ E+ E++ E + E++ +E + + +++ EK
Sbjct: 382 KVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKG 441
Query: 339 KERERERERDRDRDRT--KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
+ + +RE+ ++ T KE +D ++D++ E S ++ + + KS++ E
Sbjct: 442 TKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 501
Query: 397 REREREREREREREREREREREREREREREKDKK-----RDREEDEEDAYERRKLERK-- 449
+ + E R R +E E + E K+ R R E E + +E+ K +++
Sbjct: 502 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 561
Query: 450 ---LREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKR 495
L E + +ER K E E+++ +E REEE +R + +E +R
Sbjct: 562 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
Score = 61.2 bits (147), Expect = 4e-09
Identities = 55/237 (23%), Positives = 106/237 (44%), Gaps = 20/237 (8%)
Query: 390 DRERERERERERERERERER---EREREREREREREREREKDKKRDREEDEEDAYERRKL 446
+R RE R++ E E ER +R + E E RER R ++R R++ EE++ +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 447 ERKLREKEAAYQERLK----NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLED 502
+ ++ + + E K N ++ + E+ A REE R++ + + +R KEF
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF--- 121
Query: 503 YDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAEL 562
DP S L R + + E + ++E+ E ++R E
Sbjct: 122 ------DPTITDASL---SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSY 172
Query: 563 QRME-QEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLR 618
Q+ + ++AE ++ ++E E EE+ + E + E +EE+ Q+ + +L+
Sbjct: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLK 229
>gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]
Length = 2240
Score = 130 bits (326), Expect = 7e-30
Identities = 65/142 (45%), Positives = 96/142 (67%), Gaps = 1/142 (0%)
Query: 298 KEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKER 357
+++ER ++ + + E + R +R RERER R +E++ +R RE DR RD+ R
Sbjct: 2086 RQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSR 2145
Query: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
D DR+RER +RDRER +DR K+ RSRE+SR+RERER+R R+R+R R RER+R++ R+R
Sbjct: 2146 DWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDR 2205
Query: 418 ERERER-EREKDKKRDREEDEE 438
ER R+R +R K K+ R+ E
Sbjct: 2206 ERGRDRKDRSKSKESARDPKPE 2227
Score = 121 bits (303), Expect = 3e-27
Identities = 62/138 (44%), Positives = 91/138 (65%), Gaps = 5/138 (3%)
Query: 308 ERRERER----ERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR 363
E R+RER +E+ E + + +R RE+E+ R RERD DR R +R RD+D
Sbjct: 2084 EGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDS 2143
Query: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER 423
RD DR+RERS++R+++R R K DR RER R RERER+R R+R+R R RER+R++ R
Sbjct: 2144 SRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKAR 2203
Query: 424 EREKDK-KRDREEDEEDA 440
+RE+ + ++DR + +E A
Sbjct: 2204 DRERGRDRKDRSKSKESA 2221
Score = 117 bits (293), Expect = 4e-26
Identities = 58/143 (40%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Query: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
E KG E Q E +RER +E+ E + + +R +E+ER R R+RD D
Sbjct: 2072 EGKGH-EYRNQTFEGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWD 2130
Query: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERE 412
R +E DR RD++ RD DR R N+DR R ++ ++ +R RER R RERER+R R+R+
Sbjct: 2131 RPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRD 2190
Query: 413 REREREREREREREKDKKRDREE 435
R R RER+R++ R++++ RDR++
Sbjct: 2191 RSRSRERDRDKARDRERGRDRKD 2213
Score = 111 bits (277), Expect = 3e-24
Identities = 63/165 (38%), Positives = 94/165 (56%), Gaps = 10/165 (6%)
Query: 299 EKERQEIEKERRERERERERERERREREREREREREREKEKER-------ERERERDRDR 351
E + Q + RE + R + R+RER +EK E +R R+R+R
Sbjct: 2060 EADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERER 2119
Query: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERER 411
R R+RD DR R+ DR R++ S R+ DR+R R +RDRERE +R +E +R RER R R
Sbjct: 2120 GRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNR 2179
Query: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
ERER+R R+R+R R +++ RD+ D E +R+ + + KE+A
Sbjct: 2180 ERERDRRRDRDRSRSRERDRDKARDRERGRDRKD---RSKSKESA 2221
Score = 107 bits (267), Expect = 5e-23
Identities = 63/145 (43%), Positives = 88/145 (60%), Gaps = 17/145 (11%)
Query: 296 GKKEKERQE-------IEKERRERERERERERERR-EREREREREREREKEKERERERER 347
G KEK +E E RRERER R RER +R RE +R R+++ ++ +R RER
Sbjct: 2094 GPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRER 2153
Query: 348 DRDRDRTKERDR----DRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
+RDR +E DR DR RER R+R+RER R++DRSRSRE+ RD+ R+RER R+R
Sbjct: 2154 SANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDR-- 2211
Query: 404 EREREREREREREREREREREREKD 428
++R + +E R+ + E R D
Sbjct: 2212 ---KDRSKSKESARDPKPEASRASD 2233
Score = 94.0 bits (232), Expect = 5e-19
Identities = 52/119 (43%), Positives = 77/119 (64%), Gaps = 11/119 (9%)
Query: 289 KKLEEEKGKKEKERQEIEKER-------RERERERERERERR-EREREREREREREKEKE 340
++ E E+G+ ++ ++ R ++ R+ +R RER R+RERE +R +E ++
Sbjct: 2113 RRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRS 2172
Query: 341 RERERERDRDRDRTKERDRDRDRERDRD--RDRERSSDRNKDRSRSREKSRDRERERER 397
RER R R+R+RDR ++RDR R RERDRD RDRER DR KDRS+S+E +RD + E R
Sbjct: 2173 RERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDR-KDRSKSKESARDPKPEASR 2230
Score = 77.4 bits (189), Expect = 5e-14
Identities = 44/162 (27%), Positives = 83/162 (51%), Gaps = 2/162 (1%)
Query: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
K E + R R+R +++ E + D S DR ++R R R SR+R+ +R
Sbjct: 2074 KGHEYRNQTFEGRQRERFDVGPKEKPLE-EPDAQGRASEDRRRERERGRNWSRERDWDRP 2132
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
RE +R R+++ R+ +R RER R+RERE D+ ++ + E + R + + R+++ +
Sbjct: 2133 REWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRS 2192
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
+ R+R++ R+ K+ + +E R+ EA R +
Sbjct: 2193 RSRERDRDKARDRERGRD-RKDRSKSKESARDPKPEASRASD 2233
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/141 (32%), Positives = 72/141 (51%), Gaps = 5/141 (3%)
Query: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
R ++R K + E + R E +R RERER R RER+ +R RE D+ RD++
Sbjct: 2086 RQRERFDVGPKEKPLEEPDAQGRASE-DRRRERERGRNWSRERDWDRPREWDRHRDKDSS 2144
Query: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
+ R + + RE+EA +R K W+ R R+++R E+E +R +R R ++E R
Sbjct: 2145 RDWDRNRERSANRDREREA---DRGKEWD-RSRERSRNRERERDRRRDRDRSRSRERDRD 2200
Query: 497 KEFLEDYDDDRDDPKYYRGSA 517
K + DR D + SA
Sbjct: 2201 KARDRERGRDRKDRSKSKESA 2221
Score = 60.5 bits (145), Expect = 6e-09
Identities = 50/179 (27%), Positives = 75/179 (41%), Gaps = 43/179 (24%)
Query: 369 RDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKD 428
R RER K++ ++ R E +R RERER R RER+ +R RE +R R+KD
Sbjct: 2086 RQRERFDVGPKEKPLEEPDAQGRASE---DRRRERERGRNWSRERDWDRPREWDRHRDKD 2142
Query: 429 KKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRRE 488
RD W+ R E+ A R+ ER +
Sbjct: 2143 SSRD-------------------------------WD-------RNRERSANRDREREAD 2164
Query: 489 MAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRD--REKEMEADERDRKREKEELEE 545
KE R +E + + +RD + S ++R RD R++E D +DR + KE +
Sbjct: 2165 RGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKESARD 2223
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/98 (38%), Positives = 57/98 (58%), Gaps = 9/98 (9%)
Query: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK 337
+RE S RD + E ++GK E +R RERER+R R+R+R R RER+R++ R++
Sbjct: 2150 NRERSANRDRER--EADRGK-EWDRSRERSRNRERERDRRRDRDR-SRSRERDRDKARDR 2205
Query: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSS 375
E+ R+R +DR ++KE RD E R D +S
Sbjct: 2206 ERGRDR-----KDRSKSKESARDPKPEASRASDAGTAS 2238
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/164 (23%), Positives = 74/164 (45%), Gaps = 22/164 (13%)
Query: 421 REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
R+RER +++ +E DA R +R+ + R ++W+ R R+ R +K++
Sbjct: 2086 RQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWD-RPREWDRHRDKDSS 2144
Query: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540
R+ +R RE + R +E + DR ++R R+RE+ ERDR+R++
Sbjct: 2145 RDWDRNRERSANRDREREADRGKEWDRS----------RERSRNRER-----ERDRRRDR 2189
Query: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE 584
+ E D + +R +R + + ++P+ E
Sbjct: 2190 DRSRS------RERDRDKARDRERGRDRKDRSKSKESARDPKPE 2227
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 45/212 (21%)
Query: 421 REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
RE + + + + E + + ++ E+ L E +A Q R RER++ R + + E
Sbjct: 2071 REGKGHEYRNQTFEGRQRERFDVGPKEKPLEEPDA--QGRASEDRRRERERGRNWSR--E 2126
Query: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD---ERDRK 537
R+ +R RE + R K+ D+D +R+ R +R++E EAD E DR
Sbjct: 2127 RDWDRPREW--DRHRDKDSSRDWDRNRE------------RSANRDREREADRGKEWDRS 2172
Query: 538 REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
RE+ + E+E +RRR + S E + +K E+
Sbjct: 2173 RERS---------------------RNRERERDRRRD---RDRSRSRERDRDKARDRERG 2208
Query: 598 EEPMEEEEEPEQKPCLKPTLRPISSAPSVSSA 629
+ + + E KP S A + S A
Sbjct: 2209 RDRKDRSKSKESARDPKPEASRASDAGTASQA 2240
Score = 38.1 bits (87), Expect = 0.034
Identities = 77/369 (20%), Positives = 132/369 (35%), Gaps = 84/369 (22%)
Query: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREK--EAAYQERLKNWEIRERKKT 472
+ER E+ + D D + + D ++L+ +LR K + + LK + R RKK
Sbjct: 133 KERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLRKK- 191
Query: 473 REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEA- 531
REE + EA + +E + +P+ +G Q DRE ++E
Sbjct: 192 -------RREEGPAETVGSEA---SDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEGK 241
Query: 532 ------DER--DRKREKEELE--------------------------------------E 545
DE D R K E E E
Sbjct: 242 AAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISE 301
Query: 546 IRQRLLAEGHPD---PDAELQRMEQE--AERRRQPQIKQEPESEEEE--------EEKQE 592
R RLL D P+ + +++ E +E Q + K P + E+K
Sbjct: 302 ARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKSS 361
Query: 593 KEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGN-----ATPNTPGDESPCGII 647
+++ + +E+ P K LK +P+ AP S G A P++ + C I
Sbjct: 362 EDQGIKGRIEKAANPSGKKKLK-IFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDC--I 418
Query: 648 IPHENSPDQ--QQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDD 705
+ H + + +E +PK +K+ P P + + + SV + E +
Sbjct: 419 LKHAAATMKFLSSGKEQKPKPKEKMKM-KPEKPSLPKCGAQAGIKISSVHKRPAPEKKET 477
Query: 706 VPRKRKLVP 714
+K +VP
Sbjct: 478 TVKKAVVVP 486
Score = 37.4 bits (85), Expect = 0.059
Identities = 49/229 (21%), Positives = 90/229 (39%), Gaps = 20/229 (8%)
Query: 425 REKDKKRDREEDEEDAYERRKLERKLREK-EAAYQERLKNWEIRERKKTREYEKEAEREE 483
R K K R + +D + R LRE+ A RLK E+ ++ + E+ A
Sbjct: 720 RYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVM 779
Query: 484 ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL 543
E R ++ E+K+ E D D P + D E++ E+ ++ L
Sbjct: 780 ESRTKLHNESKKTAPRQEAIPDLEDSPP----------VSDSEEQQESARAVPEKSTAPL 829
Query: 544 EEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEE---EEKQEKEEKREEP 600
++ +L + A L + + + P + EP ++++ K+E + + +
Sbjct: 830 LDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDS 889
Query: 601 MEEEEEPEQKPCLKPTLRP-ISSAPSVSSAS-----GNATPNTPGDESP 643
+ P+ + P P ++S P + SAS P PGD P
Sbjct: 890 SAPDPAPDSADEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHP 938
Score = 31.6 bits (70), Expect = 3.2
Identities = 16/51 (31%), Positives = 27/51 (52%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERER 318
E E D+R R S+ RD K + E+G+ K+R + ++ R+ + E R
Sbjct: 2180 ERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKESARDPKPEASR 2230
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 126 bits (317), Expect = 7e-29
Identities = 102/440 (23%), Positives = 214/440 (48%), Gaps = 43/440 (9%)
Query: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQM-IKGAIEVLIREYSSELNAPSQE 228
D WK + + T + ++E TK RD + ++ + E E NA QE
Sbjct: 157 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 216
Query: 229 SDSHPRKKKKEKK---EDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFR 285
+K E + +++ R+ A L L+ ++ + A + D + +E
Sbjct: 217 KLQLVESEKSEIQLNVKELKRKLERAKL----LLPQQQLQA------EADHLGKE----- 261
Query: 286 DTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERER 345
L+ K + + +E E R +++ E+ + E+ +ERE + + ++EK RE+E
Sbjct: 262 -----LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEE 316
Query: 346 ERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERER 405
+ R + E++ R+ + ++E +++ +EK R++E E+ +E E+ RE+
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQ 375
Query: 406 EREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWE 465
E+ +E+E + R+ E+ RE+E+ + E +E + + E K+ E+E QE+ +
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 466 IRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
R+ +K RE EK+ +EE+ RE +E +++ ++ + + ++ ++
Sbjct: 436 -RQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKMGEQ--------EGKMCEQ 479
Query: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
E +M+ E +R++E++ E +++ + + E + M QE E + Q ++ E EE
Sbjct: 480 EAKMQEQEEKMRRQEEKIREQEKKIREQ--EEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 586 EEEEKQEKEEKREEPMEEEE 605
+ +E++EK ++EE M E+E
Sbjct: 538 KMQEQEEKMRRQEEKMREQE 557
Score = 122 bits (306), Expect = 1e-27
Identities = 107/483 (22%), Positives = 234/483 (48%), Gaps = 68/483 (14%)
Query: 175 KKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNA----PSQESD 230
KKK N PET T+ + ++E K Q E L RE +++ Q+++
Sbjct: 74 KKKKINNGTNPETTTSGGCHSPEDEQKASHQHQ----EALRRELEAQVQTIRILTCQKTE 129
Query: 231 --------SHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREIS 282
H K+ + + D+ R + L ++ ++A+ ++ K D E++
Sbjct: 130 LQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELT 187
Query: 283 KFRD-----------THKKLEEEKGKKEKERQEIEKERRE-----RERERERERER---- 322
K RD T ++L+E+ K +++ Q +E E+ E +E +R+ ER +
Sbjct: 188 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 247
Query: 323 -RERERERE---REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378
++ + E + +E + K + + E + ++++ R+ ++ ++RE
Sbjct: 248 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ 307
Query: 379 KDRSRSREKSRDRERERERERERERERERERERERER------EREREREREREKDKKRD 432
+++ R +E+ R+ E E+E + R+ E E+E E+ E+E+ RE+++KR
Sbjct: 308 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 367
Query: 433 REEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKE 492
EE K+RE+E ++ K W R+ +K RE E++ +EE +E ++
Sbjct: 368 EEE-------------KIREQEKRQEQEAKMW--RQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 493 AKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLA 552
+E + + +++ + + + ++++R++EK++ ++ ++ RE+EE+ + ++ +
Sbjct: 413 MGEQEEKMWEQEEEMQEQE-EKMRRQEEKIREQEKKIR-EQEEKIREQEEMMQEQEEKMG 470
Query: 553 EGHP---DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
E + +A++Q E++ R+ + +QE + E+EE+ +E+EE +E E+ E E+
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530
Query: 610 KPC 612
K C
Sbjct: 531 KMC 533
Score = 113 bits (283), Expect = 6e-25
Identities = 103/462 (22%), Positives = 221/462 (47%), Gaps = 74/462 (16%)
Query: 154 EKKLLVKVDAKTKAQ--LDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI---K 208
E+ L K KA ++E ++ A + T+T+++ + + + + + Q++ K
Sbjct: 166 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 225
Query: 209 GAIEVLIREYSSELNA-----PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKED 263
I++ ++E +L P Q+ + KE + V+ + + E
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-------VSAKLQAQVEENEL 278
Query: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERR 323
N + +++++ + R+ K ++ +K++E++ EK R++ EK RR+ E E+E + R
Sbjct: 279 WNRLNQQQEEK--MWRQEEKIQEREEKIQEQE---EKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 324 ERER------EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
+E E+ RE E EK E+E+ RE++ K ++ ++ RE+++ +++E R
Sbjct: 334 RQEEMMWEKEEKIRELE-EKMHEQEKIREQEE-----KRQEEEKIREQEKRQEQEAKMWR 387
Query: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437
+++ R +E E+ RE+E + + E+ E+E + + E +E+E+ +R E+
Sbjct: 388 QEEKIREQE-----EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLK 497
E + R+ E K+RE+E QE+ + +E K + K E+EE+ RR+
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQ--------- 493
Query: 498 EFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPD 557
++++R++EK++ E + ++E ++E +++ +
Sbjct: 494 ---------------------EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 558 PDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
+ E + EQE + RR QE + E+E +++EEK +E
Sbjct: 533 CEQEEKMQEQEEKMRR-----QEEKMREQEVRLRQQEEKMQE 569
Score = 102 bits (255), Expect = 1e-21
Identities = 85/372 (22%), Positives = 190/372 (51%), Gaps = 38/372 (10%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNAR-PETVTNDDEEALDEETKRRDQMIKGAIE 212
++KL + K++ QL+ + K+K P+ + + L +E + ++ +E
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 213 VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEED 272
E + LN +E +K +E++E I + + +E++ + E+
Sbjct: 275 E--NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 273 KR--DLISREISKFRDTHKKL-EEEKGKKEKERQEIEKERRERERERERE---------- 319
+R +++ + K R+ +K+ E+EK ++++E+++ E++ RE+E+ +E+E
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392
Query: 320 RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
RE+ E+ RE+E + ++EK E+E + + +E++ R+ ++ R++E+ +
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE 452
Query: 380 DRSRSREKSRDRERERERERERE--REREREREREREREREREREREREKDKKRDREEDE 437
++ R +E+ + E+ E+E + + + +E+E + R+ E+ RE+EK K R++EE
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK-KIREQEE-- 509
Query: 438 EDAYERRKLERKLREKEAAYQER-LKNWEIRER-----KKTREYEKEAEREEERRREMAK 491
K+RE+E QE+ K WE E+ +K +E E++ R+EE+ RE
Sbjct: 510 -----------KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558
Query: 492 EAKRLKEFLEDY 503
++ +E ++++
Sbjct: 559 RLRQQEEKMQEH 570
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 125 bits (315), Expect = 1e-28
Identities = 76/270 (28%), Positives = 151/270 (55%), Gaps = 11/270 (4%)
Query: 284 FRDTHKKLEEEKGKKEKERQEIEKERR-ERERERERERERREREREREREREREKE-KER 341
F + +E++ K++ RQ+ E ER R+R E ERR E+ + E+ K E+
Sbjct: 432 FPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEK 491
Query: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
E+ + +ER+R+++RER+++ ++E+ +R K+R + RE+ +++E+E E+E+E+
Sbjct: 492 LGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEK 551
Query: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
+RE E+ER++E+E+E ER++E+E+E K +++E++ E ER KLE K+ +E + +
Sbjct: 552 QREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMV 611
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRG------ 515
+ E E +E E R++ R E KEA + E + P G
Sbjct: 612 EKQE-SENSCNKEEEPVFTRQDSNRSE--KEATPVVHETEPESGSQPRPAVLSGYFKQFQ 668
Query: 516 SALQKRLRDREKEMEADERDRKREKEELEE 545
+L R + ++++M+ + +++++ L +
Sbjct: 669 KSLPPRFQRQQEQMKQQQWQQQQQQGVLPQ 698
Score = 121 bits (304), Expect = 2e-27
Identities = 81/285 (28%), Positives = 159/285 (55%), Gaps = 29/285 (10%)
Query: 255 PYPLITKEDI-NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERE 313
P P +K+ + + E+ + +R S + K+ EEE+ + E++R+ E+ +R
Sbjct: 429 PGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRL 488
Query: 314 RER----ERE---RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERD 366
E+ E++ E RERERE+ERERE+E EKE+E+ERE++R++DR ++++++++ E++
Sbjct: 489 DEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKE 548
Query: 367 RDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERERE 426
+++ RE EK R +E+E+E ER++E+E+E ++ +E+E+E E E+ERE+
Sbjct: 549 QEKQRE------------MEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKL 596
Query: 427 KDKKRDREEDEEDAYERRKLERKL-REKEAAYQERLKNWEIRERKKTREYEKEAEREEER 485
++K RE + E E+++ E +E+E + + N R K+ E E E
Sbjct: 597 EEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSN---RSEKEATPVVHETEPESGS 653
Query: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME 530
+ A + K+F + P++ R K+ + ++++ +
Sbjct: 654 QPRPAVLSGYFKQFQKSL-----PPRFQRQQEQMKQQQWQQQQQQ 693
Score = 85.1 bits (209), Expect = 2e-16
Identities = 68/250 (27%), Positives = 126/250 (50%), Gaps = 28/250 (11%)
Query: 371 RERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKK 430
+++ +D ++ + R + + ER R+R E ER E +R+ + +R EK
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGI 494
Query: 431 RDREEDEEDAYERRKLERKLREKE---AAYQERLKNWEIRERKKTREYEKEAEREEERRR 487
+++ E+ ER + + + REKE QER K E ++R++ +E EKE E+E+E++R
Sbjct: 495 LEKQPSPEEIREREREKEREREKELEKEQEQEREKERE-KDRERQQEKEKELEKEQEKQR 553
Query: 488 EMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIR 547
EM KE K+ KE ++ + ++ K LQK ++++EKE E E++R++ +E++E
Sbjct: 554 EMEKERKQEKE--KELERQKEKEK-----ELQK-MKEQEKECEL-EKEREKLEEKIEP-- 602
Query: 548 QRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
E + +P E Q E + +P ++ + + EK P+ E EP
Sbjct: 603 ----REPNLEPMVEKQESENSCNKEEEPVFTRQDSN---------RSEKEATPVVHETEP 649
Query: 608 EQKPCLKPTL 617
E +P +
Sbjct: 650 ESGSQPRPAV 659
Score = 72.4 bits (176), Expect = 2e-12
Identities = 53/210 (25%), Positives = 112/210 (53%), Gaps = 17/210 (8%)
Query: 192 DEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVA 251
DE+ + ++ +R+ I A+E + E ++ + +K K E + +
Sbjct: 440 DEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDE----KLGIL 495
Query: 252 PLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK-----KEKERQEIE 306
P P E+I E E+++ +E+ K ++ ++ E EK + KEKE ++ +
Sbjct: 496 EKQPSP----EEIREREREKERER--EKELEKEQEQEREKEREKDRERQQEKEKELEKEQ 549
Query: 307 KERRERERERERERERR-EREREREREREREKEKERERERERDRDRDRTKERDRDRDRE- 364
+++RE E+ER++E+E+ ER++E+E+E ++ KE+E+E E E++R++ K R+ + E
Sbjct: 550 EKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEP 609
Query: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERE 394
++ E S ++ ++ +R+ S E+E
Sbjct: 610 MVEKQESENSCNKEEEPVFTRQDSNRSEKE 639
Score = 38.9 bits (89), Expect = 0.020
Identities = 105/533 (19%), Positives = 186/533 (34%), Gaps = 65/533 (12%)
Query: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
K K S P +N EE D +R + K + + E ++++
Sbjct: 983 KVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKV 1042
Query: 233 PRK-----KKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK---RDLISREISKF 284
K +K EKK+ P P P P+ + I+ E +K + +
Sbjct: 1043 TEKVVVKPEKTEKKD--LPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPS 1100
Query: 285 RDTHKKLEE------EKGKKEKERQEIEKERRERERERER--------ERERRERERERE 330
+DT K LE E K +Q + + E++ E+ ER R + +
Sbjct: 1101 QDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVK 1160
Query: 331 REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERS----SDRNKDRSRSRE 386
+E + RERD D+ R R R R R S + +R
Sbjct: 1161 KESTLPPRTYWKEARERDWFPDQGY-RGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYP 1219
Query: 387 KSRDRERERE-------REREREREREREREREREREREREREREREKDKKRDREEDEED 439
+ RD + E R+RE R + E +R R+R E + D + ++D
Sbjct: 1220 QYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKD 1279
Query: 440 AYERRKL----ERKLREKEAAYQERLK---NWEIRERKKTREYEKEAEREEERRREMAKE 492
+ + KL ER +K K + I R + Y ++ ++ + +
Sbjct: 1280 SLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEP 1339
Query: 493 AKRLK--EFLEDYDDDRDDPKYYRGSALQK-RLRDREKEMEADERDRKREKEELEEIRQR 549
+R + F D P R S L++ RD + E + + E Q
Sbjct: 1340 TRRGRGGTFRRGGRDPGGRPS--RPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQF 1397
Query: 550 LLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
+ P ++ + ER R+ + + P ++ ++ +E E + E
Sbjct: 1398 IPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLRE---REAASKSNEVVA 1454
Query: 610 KPCLKPTLRPISSAP--SVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPE 660
P T+ ++ P ++ SGN TP+ + ++NS DQ E
Sbjct: 1455 VP-TNGTVNNVAQEPVNTLGDISGNKTPD-----------LSNQNSSDQANEE 1495
Score = 38.1 bits (87), Expect = 0.034
Identities = 42/198 (21%), Positives = 73/198 (36%), Gaps = 9/198 (4%)
Query: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEI---EKERRERERERE 317
K D E + +SR + R H + E Q+ +E R E +
Sbjct: 859 KADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQ 918
Query: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
R+R ++ E+ E + R + +R E+ + RSS+
Sbjct: 919 PSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEG 978
Query: 378 NKDRSRSREKSRDRERERERERERERERERERER----EREREREREREREREKDKKRDR 433
K + KS R R RE +R R ++ R+ + ERE+ K+K+ ++
Sbjct: 979 PKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEK 1038
Query: 434 EE--DEEDAYERRKLERK 449
E E+ + K E+K
Sbjct: 1039 AEKVTEKVVVKPEKTEKK 1056
Score = 35.4 bits (80), Expect = 0.22
Identities = 41/190 (21%), Positives = 77/190 (40%), Gaps = 15/190 (7%)
Query: 455 AAYQERLKNWEIRERKK------TREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD 508
A +ER+ E + +K + +K E+ E + K R + E + +
Sbjct: 906 APQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEE 965
Query: 509 DPK---YYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRM 565
PK + R S K + + + E R EE+ R + P L+ M
Sbjct: 966 KPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRR-EEVNDRPVRRSGPIKKPVLRDM 1024
Query: 566 EQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE----EPMEEEEEPEQKPCLKPTLRP-I 620
++E E+R++ + ++ + E+ K EK EK++ P + P Q + P ++P
Sbjct: 1025 KEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEA 1084
Query: 621 SSAPSVSSAS 630
PS +A+
Sbjct: 1085 EKFPSTETAT 1094
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 118 bits (296), Expect = 2e-26
Identities = 73/226 (32%), Positives = 115/226 (50%), Gaps = 11/226 (4%)
Query: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK 337
SR S+ R+ +K + E G+K + R ++ RR +++ ++ + E ++E + K
Sbjct: 41 SRSRSRSRERKRKSDNE-GRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSD--K 97
Query: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRE-----RSSDRNKDRSRSREKSRDRE 392
+ER E DR + KER R R R R RE RS +R K RSRSRE+ + R
Sbjct: 98 GRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRS 157
Query: 393 RERERERERERERERERE-REREREREREREREREKDKKRDREEDEEDAYER-RKLERKL 450
R RER++ R R RER+R R R R R R R R R + + R R D + E+ R+ R L
Sbjct: 158 RSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSL 217
Query: 451 REKEAAYQERLKNWEI-RERKKTREYEKEAEREEERRREMAKEAKR 495
+ R +N + + R E+ + +E+R +EM ++ K+
Sbjct: 218 SRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQ 263
Score = 114 bits (286), Expect = 3e-25
Identities = 71/256 (27%), Positives = 125/256 (48%), Gaps = 11/256 (4%)
Query: 298 KEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKER 357
K+KE+ E+ R + R R R RER+R+ + E K R R R ++ R +K++
Sbjct: 22 KKKEQSEVSVSPRASKHHYSRSRSR---SRERKRKSDNEGRKHRSRSRSKEGRRHESKDK 78
Query: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
+ + + + D+E SSD+ ++R S E DR + +ER+ R R R R RER R R
Sbjct: 79 SSKKHKSEEHN-DKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-RHR 136
Query: 418 EREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEK 477
R RER++ + + R+R++ + ER+K + RE++ + R R R + R +
Sbjct: 137 SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSR-----SRSRSRHRHRTR 191
Query: 478 EAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYY-RGSALQKRLRDREKEMEADERDR 536
R R R+ K ++ + F P + R +A+ + + A +
Sbjct: 192 SRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQE 251
Query: 537 KREKEELEEIRQRLLA 552
+REKE +E+ +Q+ +A
Sbjct: 252 QREKEMVEKQKQQEIA 267
Score = 100 bits (250), Expect = 4e-21
Identities = 70/264 (26%), Positives = 121/264 (45%), Gaps = 18/264 (6%)
Query: 197 DEETKRRDQMIKGAIEVLIREYS---SELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL 253
D + K+ + + YS S ++SD+ RK + + RR
Sbjct: 19 DRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHE---- 74
Query: 254 IPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERE 313
+K+ + E+ D +E S + + E G+ +R+E K R R
Sbjct: 75 ------SKDKSSKKHKSEEHND---KEHSSDKGRERLNSSENGEDRHKRKE-RKSSRGRS 124
Query: 314 RERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE-RDRDRDRE 372
R R RERR R R RER++ R + +ER++ R R R+R +++ R R+R R R R R R
Sbjct: 125 HSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRS 184
Query: 373 RSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRD 432
R R + RSR+R +SRDR++ E+ R R R R R + + ++ +
Sbjct: 185 RHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLE 244
Query: 433 REEDEEDAYERRKLERKLREKEAA 456
R + ++ E+ +E++ +++ AA
Sbjct: 245 RAKKLQEQREKEMVEKQKQQEIAA 268
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/305 (22%), Positives = 131/305 (42%), Gaps = 51/305 (16%)
Query: 299 EKERQEIEKERRERERERERERER-----REREREREREREREKEKERERERERDRDRDR 353
+ ER + E+ +R++++E+ R + R R R +E++R+ + E + R R
Sbjct: 5 DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSR 64
Query: 354 TKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER 413
++ ++ R +D+ + +S + N D+ S +K R+R E +R + +ER+ R R
Sbjct: 65 SRSKEGRRHESKDKSSKKHKSEEHN-DKEHSSDKGRERLNSSENGEDRHKRKERKSSRGR 123
Query: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTR 473
R R RER R + + R+R++ + ER+K R ++R
Sbjct: 124 SHSRSRSRER-RHRSRSRERKKSRSRSRERKK----------------------SRSRSR 160
Query: 474 EYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADE 533
E +K R ER+R + + R ++ + + R R R
Sbjct: 161 ERKKSRSRSRERKRRIRSRS-------------RSRSRHRHRTRSRSRTRSRS------- 200
Query: 534 RDRKREKEELEEIRQRLLAEGHPDP--DAELQRMEQEAERRRQPQIKQEPESEEEEEEKQ 591
RDRK+ E+ + L P P QEA RR + K+ E E+E ++
Sbjct: 201 RDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEK 260
Query: 592 EKEEK 596
+K+++
Sbjct: 261 QKQQE 265
Score = 60.1 bits (144), Expect = 8e-09
Identities = 58/264 (21%), Positives = 97/264 (36%), Gaps = 43/264 (16%)
Query: 374 SSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER---------- 423
+SD +D + S DR++++E+ R + R R R RER+R
Sbjct: 3 ASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHR 62
Query: 424 -----------------------------EREKDKKRDREEDEEDAYERRKLERKLREKE 454
E DK R+R E+ +R K ++ +
Sbjct: 63 SRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHK-RKERKSSR 121
Query: 455 AAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYR 514
R ++ E R R ++RE +K R ER++ ++ +R K + R R
Sbjct: 122 GRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSR 181
Query: 515 GSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDP--DAELQRMEQEAERR 572
+ + + RDRK+ E+ + L P P QEA R
Sbjct: 182 SRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALAR 241
Query: 573 RQPQIKQEPESEEEE-EEKQEKEE 595
R + K+ E E+E EKQ+++E
Sbjct: 242 RLERAKKLQEQREKEMVEKQKQQE 265
Score = 33.9 bits (76), Expect = 0.65
Identities = 34/177 (19%), Positives = 74/177 (41%), Gaps = 15/177 (8%)
Query: 428 DKKRDREEDEEDAYERRKLERKLREKEAAYQERL-KNWEIRERKKTREYEKEAERE--EE 484
D +RD E+ + +R ++K + E + R K+ R R ++RE +++++ E +
Sbjct: 5 DTERDGLAPEKTSPDR---DKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKH 61
Query: 485 RRREMAKEAKRL----KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540
R R +KE +R K + ++ +D ++ R+R E E KR++
Sbjct: 62 RSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKG-----RERLNSSENGEDRHKRKE 116
Query: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
+ R + R +++ R + + K S E ++ + E++
Sbjct: 117 RKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERK 173
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 117 bits (292), Expect = 6e-26
Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 292 EEEKGKKEKERQEI-EKERRERERERERERERREREREREREREREKEKE-RERERERDR 349
+E+ K K EI ++++R +E+E + E +R + +R+ +R+ +E E R+ E
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITI 62
Query: 350 DRDRTKERDRDRDRERDRD----RDRERSSDRNKDRSRSREKSRDRERERERERERERER 405
+ D DR + D + ++ S + K R EK ++++ R +E+ERE ER
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 406 EREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWE 465
R+R RE + + RE ER++ ++ R+ E D E+ LERK RE+E +E+ K E
Sbjct: 123 -RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ--LERK-RERERKMREQQK--E 176
Query: 466 IRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525
RE+K+ +E +E E RRE++ + ++E DY D + R R R
Sbjct: 177 QREQKERERRAEERRKEREARREVSAHHRTMRE---DYSDKVKASHWSRSPPRPPRER-- 231
Query: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
E + + ++E++EE + LL++ D+E + E+ +E E EE
Sbjct: 232 ---FELGDGRKPVKEEKMEE--RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 286
Query: 586 EEEEKQ--EKEEKREEPMEEEEEPEQ 609
EEEE++ EE EE EEEEE E+
Sbjct: 287 EEEEEEGSTSEESEEEEEEEEEEEEE 312
Score = 112 bits (280), Expect = 1e-24
Identities = 92/354 (25%), Positives = 160/354 (45%), Gaps = 44/354 (12%)
Query: 261 KEDINAIEMEED---KRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERE 317
K +I ++ +D KRD S E + RD ++ +E ++ + +
Sbjct: 29 KAEIKRLKNSDDRDSKRD--SLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIK 86
Query: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
++ +E+ R+ E+ KEK+ R +E++R+ +R K ++D+ R R +R
Sbjct: 87 PPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKAR-------REWER 139
Query: 378 NKDRSRSREKSRDRERERERERERERERERE-REREREREREREREREREKDKKRDREED 436
K R +RE SR RER+R + ER+RERER+ RE+++E+ ++ERER E+ +K
Sbjct: 140 QKRREMAREHSR-RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR 198
Query: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
E A+ R E + +A++ R RER + + K + E+ R++ +
Sbjct: 199 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD---- 254
Query: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
L+D D S+ + E+E E +E + EG
Sbjct: 255 ---LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE----------------EGST 295
Query: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
++E + E+E E ++E S EE +Q EE EE M E+EE E +
Sbjct: 296 SEESEEEEEEEEEE-------EEETGSNSEEASEQSAEEVSEEEMSEDEERENE 342
Score = 108 bits (271), Expect = 2e-23
Identities = 83/343 (24%), Positives = 158/343 (46%), Gaps = 9/343 (2%)
Query: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327
E + K EI + +++ + + +E E ++ E R RE +R
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGE 78
Query: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
E + + ++ +E+ R ++ KE+ R +E++R+ +R + +D++R RE
Sbjct: 79 EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKAR-REW 137
Query: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
R + RE RE R RER+R + ER+RERER+ ++ ++R+++E E A ERRK E
Sbjct: 138 ERQKRREMAREHSR---RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK-E 193
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
R+ R + +A+ ++ + ++ K + + R R E+ K +KE + ++R
Sbjct: 194 REARREVSAHHRTMRE-DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE---EKMEER 249
Query: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
D + + +R + A+ E+EE EE + + + E + E+
Sbjct: 250 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 309
Query: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
E E + E +EE EE+ ++E+RE PE +
Sbjct: 310 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESR 352
Score = 97.4 bits (241), Expect = 5e-20
Identities = 95/415 (22%), Positives = 185/415 (44%), Gaps = 35/415 (8%)
Query: 152 IGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAI 211
+G++K KV KT ++ + K ++K A + + N D+ ++ ++ +
Sbjct: 1 MGDEKDSWKV--KTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCM 58
Query: 212 EVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEE 271
E+ IR N+P + DS + + +++D P P + KE ++ + E+
Sbjct: 59 EITIR------NSPYRREDS---MEDRGEEDDSLAIKP-----PQQMSRKEKVHHRKDEK 104
Query: 272 DKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER---- 327
K +R K R+ H++ + + +++K R+E E+++R RE RE RRER+R
Sbjct: 105 RKEKKHARVKEKERE-HERRKRHREEQDKARREWERQKR---REMAREHSRRERDRLEQL 160
Query: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
ER+RERER+ ++++ +RE+ R +ER ++R+ R+ + D+ ++
Sbjct: 161 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 220
Query: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
SR R RER + + + E+ ER+ + + D +R E + E
Sbjct: 221 SRSPPRP-PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 279
Query: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
+ E+E +E E E ++ E E+E E + A+ + E D++R
Sbjct: 280 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER 339
Query: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE--IRQRLLAEGHPDPDA 560
++ + L E + D + + +EE+ E + L EG PD+
Sbjct: 340 ENENHL--------LVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDS 386
Score = 53.5 bits (127), Expect = 8e-07
Identities = 74/301 (24%), Positives = 132/301 (43%), Gaps = 39/301 (12%)
Query: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE 474
+E++R +E+E + + KR + D+ D+ +R LE E ++ IR RE
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDS-KRDSLE------EGELRDHCMEITIRNSPYRRE 70
Query: 475 YEKEAEREEERRREMAKEAKRL--KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
E +R EE K +++ KE + D++ K K R +EKE E +
Sbjct: 71 DSME-DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK--------KHARVKEKEREHE 121
Query: 533 ERDRKREKE-----ELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEE 587
R R RE++ E E ++R +A H E R+EQ ER+R+ +E + E++
Sbjct: 122 RRKRHREEQDKARREWERQKRREMAREHSR--RERDRLEQ-LERKRE----RERKMREQQ 174
Query: 588 EEKQEKEEKR---EEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPC 644
+E++E++E+ EE +E E + T+R S +S + P P +
Sbjct: 175 KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 234
Query: 645 GIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSD 704
G P +++ E R LS S+S + +S + S + E+E+ +
Sbjct: 235 G----DGRKPVKEEKMEERDL--LSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 288
Query: 705 D 705
+
Sbjct: 289 E 289
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 116 bits (291), Expect = 8e-26
Identities = 98/427 (22%), Positives = 215/427 (50%), Gaps = 63/427 (14%)
Query: 187 TVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQE--SDSHPRKKKKEKKEDI 244
T E +L EET D ++ + I + + E +APS E ++ ++ KEK ++
Sbjct: 166 TAQKRPENSLLEETLHFDHAVR--MGTYIEKLTKERDAPSLELYRNTITDEELKEKNAEL 223
Query: 245 FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
+E + +E E+ + L +D +KLE + +++ +
Sbjct: 224 ----------------QEKLRLVESEKSEIQL------NVKDLKRKLERAQLLLPQQQLQ 261
Query: 305 IEKERRERERER---ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDR 361
+E +R +E + + + + E E +++E++ R+ E+ ++++ ++ + R
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 362 DRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERER 421
++E R E+ ++ EK R++E + R+ E+ RE+E E+ RE+E + R+
Sbjct: 322 EQEEKMWRQEEKMHEQE-------EKIREQEDKMWRQEEKIREQE-EKIREQEEKMWRQE 373
Query: 422 EREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER 481
E+ RE+D+K +E+E + E K+RE+E QE++ W R+ KK RE +++
Sbjct: 374 EKIREQDEKIQEQEEE-----MWRQEEKIREQEEKRQEKM--W--RQEKKMREQDEKIRE 424
Query: 482 EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE 541
+EE ++ + L+E ++D ++ + +++++++ E++M+ E +R++E
Sbjct: 425 QEEEMWRQEEKIRELEEMMQDQEEKLRE--------VEEKMQEEEEKMQEQEEKIQRQEE 476
Query: 542 ELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK---RE 598
+++E ++ + +L + E++ + + +QE + E+EE+ QE+EEK +E
Sbjct: 477 KIQEQEEKTWRQ------EKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQE 530
Query: 599 EPMEEEE 605
E M E+E
Sbjct: 531 EKMREQE 537
Score = 105 bits (261), Expect = 2e-22
Identities = 81/337 (24%), Positives = 175/337 (51%), Gaps = 38/337 (11%)
Query: 268 EMEEDKRDLISREISKFRDTHKKL--EEEKGKKEKERQEIEKERRERERERERERERRER 325
+++E + + +E+ K R+ +K+ +EEK +++E+ ++++ R+ E+ RE+E + R
Sbjct: 305 KIQEQEEKMCEQEL-KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 326 ERE----REREREREK-EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
E+E R+ E+ RE+ EK +E+E E R ++ +E++ R + R + R D K
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD-EKI 422
Query: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
R + E R E+ RE E + + E+ RE E + + E E+ +E+E+ +R E+ +E
Sbjct: 423 REQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQE 482
Query: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
+ + E+ L+++E +++ K W R+ +K E E++ + +EE+ M ++ ++++E
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMW--RQEEKMWEQEEKMQEQEEK---MQRQEEKMRE-- 535
Query: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
+ RL +E++M+ E + +E L ++ Q+ G ++
Sbjct: 536 -----------------QEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRES 578
Query: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
QR+ P ++ E +S+E + +Q+++ R
Sbjct: 579 GSQRLP-----TLTPILQVELKSQEAQSLQQQQDHYR 610
Score = 103 bits (258), Expect = 5e-22
Identities = 83/299 (27%), Positives = 159/299 (53%), Gaps = 44/299 (14%)
Query: 279 REISKFRDTHKKLEEEKGKKEKE---RQEIEKERRERERERERERERRERE----RERER 331
+E +R K E+E+ E+E R++ EK R+ E+ E+E + RE+E R+ E+
Sbjct: 295 QEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK 354
Query: 332 EREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR 391
RE+E EK RE+E + R ++ +E+D E+ ++ ++ R EK R++
Sbjct: 355 IREQE-EKIREQEEKMWRQEEKIREQD-------------EKIQEQEEEMWRQEEKIREQ 400
Query: 392 EREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLR 451
E +R+ + R+ ++ RE++ E+ RE+E E R+++K R+ EE +D E KLR
Sbjct: 401 EEKRQEKMWRQEKKMREQD---EKIREQEEEMWRQEEKIRELEEMMQDQ------EEKLR 451
Query: 452 EKEAAYQERLKNWEIRERKKTREYEKEAEREEE--RRREMAKEAKRLKEFLEDYDDDRDD 509
E E QE + + +E K R+ EK E+EE+ R+ ++ K+ +++ E +
Sbjct: 452 EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWE---------QE 502
Query: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQE 568
K +R ++++ ++E++M+ E +R++E++ E RL + + E++ E E
Sbjct: 503 EKMWR---QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELE 558
Score = 96.3 bits (238), Expect = 1e-19
Identities = 103/454 (22%), Positives = 216/454 (47%), Gaps = 46/454 (10%)
Query: 191 DDEEALDEETKRRDQMIKGAIEVLIREYSSE--------LNAPSQESDSHPRKKKKEKKE 242
DD+ E++K+ + +K L + + E N+ +S R++K +K
Sbjct: 87 DDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKN 146
Query: 243 DIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKER 302
FR+ V I P + ++ A + E+ L+ + EK KE++
Sbjct: 147 YTFRKRVV---IKKPWLRLGEVTAQKRPENS--LLEETLHFDHAVRMGTYIEKLTKERDA 201
Query: 303 QEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD 362
+E R E +E+ +E+ R E E+ + + ++ +R +R + +
Sbjct: 202 PSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQ 261
Query: 363 RERDR-DRDRERSSDRNKDR----------SRSREKSRDRERERERERE----------R 401
E DR ++ + S + + + ++ +E+ R+ E+ +E+E R
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
E+E + R+ E+ E+E E+ RE+E R E+ E + R+ E K+ +E +E+
Sbjct: 322 EQEEKMWRQEEKMHEQE-EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQD 380
Query: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR 521
+ + +E + R+ EK E+EE+R+ +M ++ K+++E +D + + +R +++
Sbjct: 381 EKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMRE--QDEKIREQEEEMWR---QEEK 435
Query: 522 LRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER--RRQPQIKQ 579
+R+ E EM D+ ++ RE EE + + + E + ++++++ E+ R++ +KQ
Sbjct: 436 IRELE-EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQ 494
Query: 580 EPESEEEEEEKQEKEEK---REEPMEEEEEPEQK 610
E + E+EE+ +EEK +EE M+E+EE Q+
Sbjct: 495 EEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Score = 92.8 bits (229), Expect = 1e-18
Identities = 80/364 (21%), Positives = 179/364 (49%), Gaps = 37/364 (10%)
Query: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNAR-PETVTNDDEEALDEETKRRDQMIKGAIE 212
++KL + K++ QL+ K+K P+ + + L +E + ++ +E
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283
Query: 213 VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEED 272
E + LN +E +K +E++E + + L +E + +E+
Sbjct: 284 E--NELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ---------ELKIREQEEKMWRQEE 332
Query: 273 KRDLISREISKFRDTHKKL--EEEKGKKEKERQEIEKERRERERERERERERRERERERE 330
K + + K R+ K+ +EEK ++++E+ ++E+ R+ E+ RE++ + +E+E E
Sbjct: 333 K---MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
Query: 331 REREREKEKERERERERDRDRDRTKERDRD---RDRERDRDRDRERSSD----------- 376
R+ EK +E+E +R+ R K R++D R++E + R E+ +
Sbjct: 390 MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEK 449
Query: 377 -RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREE 435
R + E+ + +E+E + +R+ E+ +E+E + R+ + ++ E+ E+++K R+
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ- 508
Query: 436 DEEDAYERRKLERKLREKEAAYQERLKNWEIR---ERKKTREYEKEAEREEERRREMAKE 492
EE +E+ + ++ EK +E+++ E+R + +K +E E + EER ++ ++
Sbjct: 509 -EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQK 567
Query: 493 AKRL 496
A+ L
Sbjct: 568 AELL 571
Score = 75.5 bits (184), Expect = 2e-13
Identities = 75/346 (21%), Positives = 157/346 (45%), Gaps = 32/346 (9%)
Query: 156 KLLVKVDAKTKAQLDE---WKAKKKASNGNA--RPETVTNDDEEALDEETKRRDQMIK-G 209
K L V AK +AQ++E W + + E + +E+ ++E K R+Q K
Sbjct: 269 KELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMW 328
Query: 210 AIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEM 269
E + E ++ QE +++K ++E+ R I ++D E
Sbjct: 329 RQEEKMHEQEEKIR--EQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER------- 322
EE+ + R+ K R+ +K +E+ ++EK+ +E +++ RE+E E R+ E+
Sbjct: 387 EEE----MWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 323 ----REREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378
E+ RE E + + E+EK +E+E + R ++ +E++ R+ + E+ ++
Sbjct: 443 MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE 502
Query: 379 KDRSRSREKSRDRER---------EREREREREREREREREREREREREREREREREKDK 429
+ R EK ++E +R+ E+ RE+E ++ E+ +E+E + E+
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLG 562
Query: 430 KRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREY 475
K ++ + R ++L Q LK+ E + ++ +++
Sbjct: 563 KLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDH 608
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/400 (20%), Positives = 164/400 (41%), Gaps = 79/400 (19%)
Query: 282 SKFRDTHKK-LEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKE 340
SKF T L +E + ++E++ + R + + RE+ + + + E E E
Sbjct: 15 SKFDPTKSPVLSDEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLE 74
Query: 341 RERERERDRDRDRTKERDRDRDRERDRDRDRERSS----------------------DRN 378
+R R TK D D D E D + + S +N
Sbjct: 75 -------NRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKN 127
Query: 379 KDRSRSREKSRDRERERERERERER---ERERERERERERERERERERERE--------- 426
D +S K R + + R+R ++ R E ++ E E
Sbjct: 128 SDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVR 187
Query: 427 -----KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER 481
+ ++R+ + Y + +L+EK A QE+L+ E E+ + + K+ +R
Sbjct: 188 MGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVE-SEKSEIQLNVKDLKR 246
Query: 482 EEER------RREMAKEAKRLKEFLEDYD----------------DDRDDPKYYRGSALQ 519
+ ER ++++ EA RL + L+ + + + K +R
Sbjct: 247 KLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKI 306
Query: 520 KRLRDR--EKEMEADERDRK--REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575
+ ++ E+E++ E++ K R++E++ E +++ + E + EQE + R Q
Sbjct: 307 QEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQE 366
Query: 576 Q--IKQEPESEEEEEEKQEKEE---KREEPMEEEEEPEQK 610
+ +QE + E++E+ QE+EE ++EE + E+EE Q+
Sbjct: 367 EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQE 406
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/318 (22%), Positives = 128/318 (40%), Gaps = 62/318 (19%)
Query: 344 ERERDRDRDRTKE---RDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE 400
ER D TK D D D + ++ ++S RNK + REKS E+ +
Sbjct: 10 ERANSSKFDPTKSPVLSDEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQLS-- 67
Query: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER---KLREKEAAY 457
E E E + R +R E D D EE E+ + L+R L + EA
Sbjct: 68 -------EMEAYLENRKRRGTKRWDEDD---DLEESEDSKQCKESLKRVTFTLPDDEAIE 117
Query: 458 QERLKNWEIRERKKTREYEKEAEREEE-----RRREMAKE-------------------- 492
+ + + + ++K E+ E R+R + K+
Sbjct: 118 DAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLE 177
Query: 493 -------AKRLKEFLEDYDDDRDDP--KYYRGSALQKRLRDREKEMEADERDRKREKEEL 543
A R+ ++E +RD P + YR + + L+++ E++ R + EK E+
Sbjct: 178 ETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEI 237
Query: 544 E----EIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE-----KQEKE 594
+ +++++L P +LQ +E + + + + +++ EE E Q++E
Sbjct: 238 QLNVKDLKRKLERAQLLLPQQQLQ-VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQE 296
Query: 595 EKREEPMEEEEEPEQKPC 612
EK E+ +E E+K C
Sbjct: 297 EKMWRQEEKIQEQEEKMC 314
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 115 bits (289), Expect = 1e-25
Identities = 91/333 (27%), Positives = 155/333 (46%), Gaps = 24/333 (7%)
Query: 283 KFRDTHKKLEEEKGKKEKERQ-EIEKERRERERERER----ERERREREREREREREREK 337
K + + L+E+K +KE+E + EI++ + +R+ +R E E R+ E +
Sbjct: 9 KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYR 68
Query: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD-RERERE 396
++ +R + D K + +E+ R E+ ++ + RS S E + R +E+E
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE 128
Query: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456
RE ER R+R RE + + RE ER++ RE ++ R + E +R+ ERK+RE++
Sbjct: 129 REHER-RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK- 186
Query: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516
E RE+K+ +E +E E RRE++ + ++ EDY D + R
Sbjct: 187 --------EQREQKERERRAEERRKEREARREVSAHHRTMR---EDYSDKVKASHWSRSP 235
Query: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576
R R + ++ K E+ +L Q + D + + E +
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI-----SDSERKTSSAESSSAESGSGS 290
Query: 577 IKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
++E E EEEEEE EE EE EEEEE E+
Sbjct: 291 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 323
Score = 111 bits (278), Expect = 2e-24
Identities = 95/365 (26%), Positives = 168/365 (46%), Gaps = 37/365 (10%)
Query: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEI----EKERRERERERERERE---- 321
+E+K ++ + S RD+ K+ E+G+ R EI RRE E E +
Sbjct: 26 QEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLA 84
Query: 322 --------RREREREREREREREKEKERERERERDRD-RDRTKERDRDRDRERDRDRDRE 372
R+E+ R+ E+ +EK + R E + R + KER+ +R + ++D+
Sbjct: 85 IKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKA 144
Query: 373 RSS-DRNKDRSRSREKSRDRERERERERERERERERE-REREREREREREREREREKDKK 430
R +R K R +RE SR RER+R + ER+RERER+ RE+++E+ ++ERER E+ +K
Sbjct: 145 RREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK 203
Query: 431 RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMA 490
E A+ R E + +A++ R RER + + K + E+ R++
Sbjct: 204 EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLL 263
Query: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
+ + + + E + GS ++ + E+E E + E+EE EE
Sbjct: 264 SDLQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE----- 317
Query: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE-----KEEKREEPMEEEE 605
+ + E +EA + ++ +E SE+EE E + E + + E E
Sbjct: 318 -----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 372
Query: 606 EPEQK 610
E E++
Sbjct: 373 EAEEE 377
Score = 65.9 bits (159), Expect = 2e-10
Identities = 65/299 (21%), Positives = 134/299 (44%), Gaps = 24/299 (8%)
Query: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTRE 474
+E++R +E+E + + KR + D+ D+ E +LR+ R + ++
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPY-----RREDS 72
Query: 475 YEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQ--KRLRDREKEMEAD 532
E E ++ + ++ R ++ D+ R + + +R + + K R +EKE E +
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHE 132
Query: 533 ERDRKREKE-----ELEEIRQRLLAEGHPDPDAE-LQRMEQEAERRRQPQIKQEPESEEE 586
R R RE++ E E ++R +A H + + L+++E++ ER R+ + E ++E
Sbjct: 133 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR-----EQQKE 187
Query: 587 EEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGI 646
+ E++E+E + EE +E E + T+R S +S + P P + G
Sbjct: 188 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG- 246
Query: 647 IIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDD 705
P +++ E R LS S+S + +S + S + E+E+ ++
Sbjct: 247 ---DGRKPVKEEKMEERDL--LSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 115 bits (288), Expect = 2e-25
Identities = 93/433 (21%), Positives = 220/433 (50%), Gaps = 24/433 (5%)
Query: 188 VTNDDEEALDEETKRRDQMI---KGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDI 244
+TN++ + + E + Q++ K I++ I+E +L E+D P ++ + +E
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKL-----ETDKIPLPQEGQVREQE 58
Query: 245 FR-RFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK-KEKER 302
+ R + +E + +E + + + + R+ ++ E++G+ +E+E
Sbjct: 59 GQVREQEGQVREQEGQVREQEGQVREQEGQ---VREQEGQVREQEGQVREQEGQVREQEG 115
Query: 303 QEIEKERRERERE---RERERERRERERE-REREREREKEKERERERERDRDRDRTKERD 358
Q E+E + RE+E RE+E + RE+E + RE+E + +++ + RE+E + R+
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175
Query: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE 418
++ + RE+ + + E+ E+ E+E + +++ E+ E+E + ++
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQ---EEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232
Query: 419 REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478
E+ E+E+ ++ E+ ++ + RK E ++RE+E Q R + ++ ++K+ E E++
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE--QMREQEEQMLKQKEQTEQEEQ 290
Query: 479 AEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKR 538
+EE+ RE ++ + +E + + ++ + + G ++ +E+ E E+ K+
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350
Query: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPE--SEEEEEEKQEKEEK 596
E++ E+ Q E E R ++E R+++ Q++++ E E++E+ ++KE+
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Query: 597 REEPMEEEEEPEQ 609
RE+ + E+ EQ
Sbjct: 411 REQEEQMGEQKEQ 423
Score = 109 bits (272), Expect = 1e-23
Identities = 93/387 (24%), Positives = 209/387 (54%), Gaps = 40/387 (10%)
Query: 261 KEDINAIEMEEDKRDLISREISKFRDTHK-------KLEEEKGK-KEKERQEIEKERRER 312
+E++ +E E+ + L +E+ + +T K ++ E++G+ +E+E Q E+E + R
Sbjct: 17 QEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVR 76
Query: 313 ERE---RERERERRERE---REREREREREKEKERERERERDRDRDRTKERDRDRDRERD 366
E+E RE+E + RE+E RE+E + ++ + RE+E + + +E++ +
Sbjct: 77 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 136
Query: 367 RDRDRERSSDRNKDRSRSRE-KSRDRE---RERE---RERE---RERE---RERER---E 410
+ R++E + + R +E + R++E RE+E RE+E RE+E RE+E E
Sbjct: 137 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGE 196
Query: 411 REREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERK 470
+E + + E+ E+E+ ++ E+ E + RK E ++ E+E Q++ + + ++ +
Sbjct: 197 QEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ-KQEE 255
Query: 471 KTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEME 530
+ R+ E++ +EE+ RE ++ + KE E + + + R ++++R++E++M
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQ--EEQMREQEEQMR 313
Query: 531 ADERDRKREKEELEEIRQRLLAEGHP--DPDAELQRMEQEAERRRQPQIKQEPESEEEEE 588
E + ++E++ + +++ + + ++ + E++ + + KQE + ++EE
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 589 EKQEKEE---KREEPMEEEEEP--EQK 610
+ +++EE K+EE M ++EE EQK
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQK 400
Score = 97.1 bits (240), Expect = 6e-20
Identities = 74/341 (21%), Positives = 175/341 (51%), Gaps = 21/341 (6%)
Query: 285 RDTHKKLEEEKGKKEKERQEIEKERRE-----RERERERERERRERERE---RERERERE 336
R T+++L+E+ + ++E Q +E E+ E +E +R+ E ++ +E RE+E +
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE-KSRDRERE- 394
+++ + RE+E + R+++ + RE+ + + RE + + RE+E
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 395 --REREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLRE 452
RE+E + + + RE+E + + + RE+E + + E + R+ E ++RE
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182
Query: 453 KEAAYQERLKNWEIRERKKTREYEKEAEREEERRR---EMAKEAKRLKEFLEDYDDDRDD 509
+E +E+ +E + + E+ E+EE+ ++ +M ++ +++++ E + +
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
+ +++++ +E++M E + ++E++ E +++L + + E Q EQE
Sbjct: 243 VQ-----KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ-KEQTEQEEQTGEQEE 296
Query: 570 ERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
+ R Q + +E E + E+E+Q +E++ + +EE+ EQK
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK 337
Score = 70.9 bits (172), Expect = 5e-12
Identities = 59/307 (19%), Positives = 145/307 (47%), Gaps = 30/307 (9%)
Query: 309 RRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD 368
R E +E+ E +E + E E+ + +E +R+ + D+ + + R++E
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQE---G 59
Query: 369 RDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKD 428
+ RE+ + + RE+ + RE+E + + + RE+E + + + RE+E
Sbjct: 60 QVREQEGQVREQEGQVREQEG---QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 116
Query: 429 KKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERK-KTREYEKEAEREEERRR 487
+ + E + R+ E ++RE+E Q R + ++RE++ + RE E + +E + R
Sbjct: 117 VREQEGQVREQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVREQEGQVREQEGQVR 174
Query: 488 EMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIR 547
E + + + + + + + + G ++E++M E ++++E++ E
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMG--------EQEEQMGEQEEQMQKQEEQMGEQE 226
Query: 548 QRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
+++ R ++E ++ Q++++ E +++EE+ K+E++ EE+
Sbjct: 227 EQM-------------RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 608 EQKPCLK 614
+++ LK
Sbjct: 274 QEEQMLK 280
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.131 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,428,639
Number of Sequences: 37866
Number of extensions: 2467440
Number of successful extensions: 177236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1920
Number of HSP's successfully gapped in prelim test: 1483
Number of HSP's that attempted gapping in prelim test: 24827
Number of HSP's gapped (non-prelim): 44979
length of query: 843
length of database: 18,247,518
effective HSP length: 111
effective length of query: 732
effective length of database: 14,044,392
effective search space: 10280494944
effective search space used: 10280494944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.