BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|55741447 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [Homo sapiens] (1364 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|55741447 pleckstrin homology domain containing, family H (wit... 2748 0.0 gi|217416392 pleckstrin homology domain containing, family H (wi... 1174 0.0 gi|154354979 myosin X [Homo sapiens] 113 1e-24 gi|189083798 myosin VIIA isoform 1 [Homo sapiens] 85 4e-16 gi|189083802 myosin VIIA isoform 2 [Homo sapiens] 85 5e-16 gi|40255047 pleckstrin homology domain containing, family H (wit... 78 5e-14 gi|122937512 myosin VIIB [Homo sapiens] 72 3e-12 gi|154146216 pleckstrin homology domain containing, family A (ph... 61 6e-09 gi|118402590 myosin XV [Homo sapiens] 59 2e-08 gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 59 2e-08 gi|50234893 pleckstrin homology domain containing, family A (pho... 57 9e-08 gi|31377720 pleckstrin homology domain containing, family A (pho... 57 9e-08 gi|4505531 oxysterol binding protein [Homo sapiens] 54 8e-07 gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 54 8e-07 gi|93102364 SWAP-70 protein [Homo sapiens] 54 1e-06 gi|187608516 centaurin, beta 2 [Homo sapiens] 54 1e-06 gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 54 1e-06 gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 54 1e-06 gi|7661880 centaurin beta1 [Homo sapiens] 54 1e-06 gi|154146189 dedicator of cytokinesis 10 [Homo sapiens] 54 1e-06 gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ... 52 3e-06 gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 52 3e-06 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 52 4e-06 gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 52 4e-06 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 51 7e-06 gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 51 7e-06 gi|4758968 cytohesin 3 [Homo sapiens] 51 7e-06 gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 51 7e-06 gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 51 7e-06 gi|58331179 KIAA1688 protein [Homo sapiens] 51 9e-06 >gi|55741447 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 [Homo sapiens] Length = 1364 Score = 2748 bits (7123), Expect = 0.0 Identities = 1364/1364 (100%), Positives = 1364/1364 (100%) Query: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA Sbjct: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60 Query: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE Sbjct: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120 Query: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV Sbjct: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180 Query: 181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS 240 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS Sbjct: 181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS 240 Query: 241 SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS 300 SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS Sbjct: 241 SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS 300 Query: 301 AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG 360 AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG Sbjct: 301 AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG 360 Query: 361 LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS 420 LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS Sbjct: 361 LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS 420 Query: 421 WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA 480 WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA Sbjct: 421 WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA 480 Query: 481 TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD 540 TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD Sbjct: 481 TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD 540 Query: 541 YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF 600 YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF Sbjct: 541 YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF 600 Query: 601 VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL 660 VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL Sbjct: 601 VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL 660 Query: 661 EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH 720 EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH Sbjct: 661 EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH 720 Query: 721 EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT 780 EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT Sbjct: 721 EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT 780 Query: 781 KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS 840 KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS Sbjct: 781 KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS 840 Query: 841 LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ 900 LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ Sbjct: 841 LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ 900 Query: 901 LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC 960 LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC Sbjct: 901 LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC 960 Query: 961 QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD 1020 QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD Sbjct: 961 QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD 1020 Query: 1021 EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK 1080 EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK Sbjct: 1021 EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK 1080 Query: 1081 SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM 1140 SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM Sbjct: 1081 SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM 1140 Query: 1141 AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW 1200 AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW Sbjct: 1141 AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW 1200 Query: 1201 ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN 1260 ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN Sbjct: 1201 ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN 1260 Query: 1261 TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA 1320 TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA Sbjct: 1261 TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA 1320 Query: 1321 SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364 SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL Sbjct: 1321 SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364 >gi|217416392 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Homo sapiens] Length = 1493 Score = 1174 bits (3038), Expect = 0.0 Identities = 609/1080 (56%), Positives = 780/1080 (72%), Gaps = 39/1080 (3%) Query: 306 PGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELE 365 P S L PK+R P S+ LAKRH SQPQ+ R+ A S + P E + Sbjct: 432 PSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSD---RMFGTNRNAISMIRPLRPQETD 488 Query: 366 SR---ARSREEPEKMEMEEPPPAGKNEERESPKALGAE----LEEVELGNKPPTPPLHQF 418 S E E M+ + +SP + E ++V +KPPTPPLH+F Sbjct: 489 LDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAY-SKPPTPPLHRF 547 Query: 419 SSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKG 478 SWESRIYAVA SG+R+S+ + +++ + + G ++ L+YKN+T PVYT LKG Sbjct: 548 PSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKG 607 Query: 479 RATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSE 538 +ATQIS+ PF+D+SSGS+++ SS++S R S S+SR SG GSPRA+KRGVS+SS++SE Sbjct: 608 KATQISSSPFLDDSSGSEEEDSSRSSSRTS--ESDSRSRSGPGSPRAMKRGVSLSSVASE 665 Query: 539 GDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRR 598 DYAIPPDA S D++YS+PE KL +T S S+D E LEKSGYLLKM +VK+WKRR Sbjct: 666 SDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGK--NEPLEKSGYLLKMSGKVKSWKRR 723 Query: 599 WFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPS 658 WFVL+ G+++YYKSPSDVIRKPQG ++L++ C I+RG+ QT QL +EK TYYLTADSP+ Sbjct: 724 WFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPN 783 Query: 659 LLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYR 718 +LEEWI+VLQ++L+VQA P +L G KPT+KG LTKVKHG+SK VWC L+GK YY+R Sbjct: 784 ILEEWIKVLQNVLRVQAANPLSLQPEG-KPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFR 842 Query: 719 SHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLI 778 S EDK PLG + + +A +EEVDRSCDSDEDYEA G R LLS+H T+VIHP + PTYLLI Sbjct: 843 SQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASG-RSLLSTHYTIVIHPKDQGPTYLLI 901 Query: 779 GTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLY 838 G+KHEKDTWLYHLTVAAG ++ VG+ +EQL+ KL++ +G+P S +WRHP LC+SK+G+ Sbjct: 902 GSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGII 961 Query: 839 ASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIY 898 + LTTLPSEALQTEA+KLFK+CQLFIN V++ ++DYH+SLAQ+ALQ+CL HPELQ+EI Sbjct: 962 SPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEIC 1021 Query: 899 CQLMKQTSCRPPQKY-SLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYA 957 CQL+KQT R PQ +Q WQLLALC LFLP H FLW ++ L+R+AD R+E G+YA Sbjct: 1022 CQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYA 1081 Query: 958 TYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSS 1017 YCQR VERT + G+REARPSRME++S LLRNP+HHSLPFSIPVHF NG Y VVGFD S+ Sbjct: 1082 IYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAST 1141 Query: 1018 TVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELH 1077 TV+EFL LNQ+ GMRKP+ SGFALFTDDPSGRDLEHCLQG++KICD ISKWEQA KE Sbjct: 1142 TVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQ 1201 Query: 1078 PGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMA 1137 PGK E GTR V+L YKNRLYF Q +GETDRE+LLL QT+ +I+ G FP+NK+LALEMA Sbjct: 1202 PGKCE-GTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA 1260 Query: 1138 ALMAQVEYGDLEKP-ALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML 1196 AL++QVE GD E+P + P T+ K L+QV+++F+P+RYR G EQLR L L Sbjct: 1261 ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL 1320 Query: 1197 TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSI 1256 +T+W L+G S +C+RIYLTVARKWPFFGAKLF A+P SS + +W+AV+EDG+S+ Sbjct: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL 1380 Query: 1257 LDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEAT 1316 L++N+M++ ++Y Y S+ TFGG +DDFM+VI + K EKL+F MA PKI E T Sbjct: 1381 LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKD---KPTEKLLFAMAKPKILEIT 1437 Query: 1317 FIMASYMNH------------CTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364 ++ASY+N+ ++ T P A + G Q S S TKGPTLL Sbjct: 1438 LLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQA----RMMGSQPLLSSSRPTKGPTLL 1493 Score = 181 bits (459), Expect = 4e-45 Identities = 91/171 (53%), Positives = 133/171 (77%), Gaps = 1/171 (0%) Query: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60 MAEL E VDW++RC+ LE+QL +FR+QASKIRELLA+KMQ+LE+++++AE++AE A Sbjct: 1 MAELS-EPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKA 59 Query: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120 QV VME+K+K +N++ +SE L+ K Q+L I+ KD++I LE QLE+QKQ+R +E Sbjct: 60 FQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQE 119 Query: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQ 171 AK ++EKAAKIKEWVT+KL +LE+ENQ+L+ NQ E++ ++Q L+ +Q Sbjct: 120 AKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQ 170 >gi|154354979 myosin X [Homo sapiens] Length = 2058 Score = 113 bits (282), Expect = 1e-24 Identities = 157/708 (22%), Positives = 276/708 (38%), Gaps = 98/708 (13%) Query: 626 LNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQ-SLLKVQATGPPALLRG 684 ++S C + +F +I+ + + AD+P + WI +LQ S + G ++RG Sbjct: 1338 IDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQEFIVRG 1397 Query: 685 GTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKR-PLGCLPVRD-AHIEEVDRS 742 VK K+ K W L YY+S E LG L + + D Sbjct: 1398 WLHKEVKN-SPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEK 1456 Query: 743 CDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKV 802 + Y HC + + T ++ DT A + Sbjct: 1457 IFKETGY--WNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDT------------KAPI 1502 Query: 803 GTAYEQLIGKLMDG--EGDPDSPLW-RHPMLCYSKDGLYASLTTLPS------------- 846 T +QLI + + D ++ R+P+L Y+ L++ L LP Sbjct: 1503 DTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGY 1562 Query: 847 EALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTS 906 LQ EA+K+F S Q + S+ + + Q LQ L+ E+YCQL+KQT+ Sbjct: 1563 TTLQDEAIKIFNSLQ-------QLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTN 1615 Query: 907 CRP-PQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHAD--PRSETGQYATYCQRA 963 P P + WQ+L + FLP L Y+K L+R + P SE +YA + + Sbjct: 1616 KVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYES 1675 Query: 964 VERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVDEFL 1023 +++T RE PSR E+ +++ H + V+ G + + +T E + Sbjct: 1676 LKKTKC---REFVPSRDEIEALI------HRQEMTSTVYCHGGGSCKITINSHTTAGEVV 1726 Query: 1024 QRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEG 1083 ++L + + M + S + FALF + +G ++ ++ + D ++K+E+ SE Sbjct: 1727 EKLIRGLAM-EDSRNMFALF--EYNGH-VDKAIESRTVVADVLAKFEKL-----AATSEV 1777 Query: 1084 GTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALMAQV 1143 G K +K + + + E + Q ++ G P +E +AAL Q Sbjct: 1778 GDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQY 1837 Query: 1144 EYGD--LEKPALPGPGGTSPAKAQHLLQQVLDRFHP-----------------RRYRHGA 1184 GD L P S + + + Q F P R +R G+ Sbjct: 1838 LQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGS 1897 Query: 1185 PAEQL---RHLADM------------LTTKWATLQGCSPPECIRIYLTVARKWPFFGAKL 1229 Q + DM + KW QG + + + Y+ + ++WP +G+ L Sbjct: 1898 VVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTL 1957 Query: 1230 FAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFG 1277 F + + + +W+ V+ D VS+ + + Y + +FG Sbjct: 1958 FDVECKEGGFPQE--LWLGVSADAVSVYKRGEGRPLEVFQYEHILSFG 2003 Score = 57.0 bits (136), Expect = 1e-07 Identities = 31/96 (32%), Positives = 53/96 (55%), Gaps = 8/96 (8%) Query: 581 KSGYLLKMGSQVKT-----WKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRG 635 K G+L K G T WK+RWFVLRQ ++MY+++ S+ K +G V++ + +I+ Sbjct: 1215 KQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSE--EKLKGTVEVRTAKEIIDN 1272 Query: 636 EGSQT-FQLISEKKTYYLTADSPSLLEEWIRVLQSL 670 + +I +T++L A+SP +W VL + Sbjct: 1273 TTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQV 1308 Score = 36.2 bits (82), Expect = 0.22 Identities = 35/159 (22%), Positives = 76/159 (47%), Gaps = 5/159 (3%) Query: 15 QKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLS 74 +K + + QL R ++ R+LLA+K ++ E++ E E++ + E + E + + + Sbjct: 789 KKAAIVFQKQL-RGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEE-RERERERREA 846 Query: 75 NLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEW 134 L+ E + ++ E L+ + + EL +LE Q E ++ + E ++KE Sbjct: 847 ELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQ 906 Query: 135 VTLKLAKLEMEN-QHLKSHNQRLVEQVG--SLQDALEAI 170 L L + ++ Q + R +E+ + Q+ LE++ Sbjct: 907 QELSLTEASLQKLQERRDQELRRLEEEACRAAQEFLESL 945 Score = 32.7 bits (73), Expect = 2.4 Identities = 24/87 (27%), Positives = 36/87 (41%), Gaps = 8/87 (9%) Query: 596 KRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIV-------RGEGSQTFQLISEKK 648 K+RWFVL + YYKS S+ G + LNS C +V + G + K Sbjct: 1415 KKRWFVLTHNSLDYYKS-SEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKH 1473 Query: 649 TYYLTADSPSLLEEWIRVLQSLLKVQA 675 Y L + W +Q++ +A Sbjct: 1474 CYRLYTKLLNEATRWSSAIQNVTDTKA 1500 >gi|189083798 myosin VIIA isoform 1 [Homo sapiens] Length = 2215 Score = 85.1 bits (209), Expect = 4e-16 Identities = 102/401 (25%), Positives = 165/401 (41%), Gaps = 44/401 (10%) Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947 ++ P L+ EIYCQ+ KQ + P K S + W L++LC F P F+ Y++ + H Sbjct: 1162 ILRPALRDEIYCQISKQLT-HNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFI--HG 1218 Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007 P YA YC+ + RT G R PS +E+ + + P +PV F +GT Sbjct: 1219 GPPG----YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDGT 1268 Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFT---DDPSGRDLEHCLQGSVKICD 1064 + D ++T E L +I ++ GF+L+ D S GS + D Sbjct: 1269 TKTLLTDSATTAKELCNALADKISLK--DRFGFSLYIALFDKVSSLG-----SGSDHVMD 1321 Query: 1065 AISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAG 1124 AIS+ EQ KE + R L ++ ++ E + L+ Q R + G Sbjct: 1322 AISQCEQYAKEQGAQERNAPWR---LFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1378 Query: 1125 RFPINKELAL-EMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHG 1183 + KE L E+A+ V+YG S + LL V R Sbjct: 1379 EYRCEKEDDLAELASQQYFVDYG-------------SEMILERLLNLVPTYIPDREITPL 1425 Query: 1184 APAEQLRHLADMLTTKWATLQGCSPPECIR-IYLTVAR-KWPFFGAKLFAAQPAQLSSKE 1241 E+ LA K Q + + ++ ++ AR KWP ++ + A S Sbjct: 1426 KTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLP 1485 Query: 1242 NALVWIAVNEDGVSILD-HNTMQVHITYP-YSSVTTFGGCR 1280 V +AVN GV +D + + +++P +V++ CR Sbjct: 1486 KNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECR 1526 Score = 71.6 bits (174), Expect = 5e-12 Identities = 87/400 (21%), Positives = 171/400 (42%), Gaps = 36/400 (9%) Query: 893 LQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSE 952 L+ E Y Q++KQ + +YS + W+LL LC LF P + L +V++ LQ + Sbjct: 1809 LKDEAYVQILKQLTDNHI-RYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSR-----K 1862 Query: 953 TGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1012 A C + +++ LR G R+ P +EV +I H + V+F + T Sbjct: 1863 HCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQ-----HKTTQIFHKVYFPDDTDEAFE 1917 Query: 1013 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQA 1072 + S+ +F Q + + ++ S GF+LF D + + D + Sbjct: 1918 VESSTKAKDFCQNIATRLLLK--SSEGFSLFV---KIADKVLSVPENDFFFDFVRHLTDW 1972 Query: 1073 MKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETD-RERLLLASQTSREIVAGRFPINKE 1131 +K+ P K + ++ + + + V G+ + + Q + + G +E Sbjct: 1973 IKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTRE 2032 Query: 1132 LALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLL-QQVLDRFHPRRYRHGAPAEQLR 1190 L++ AL+ +V++ + +K P + P + L+ Q ++ + P ++ A + Sbjct: 2033 EVLQLGALIYRVKFEE-DKSYFP----SIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNK 2087 Query: 1191 HLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVN 1250 H G S E +L + KWP FG+ F + + L+ IA+N Sbjct: 2088 H------------AGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILL-IAIN 2134 Query: 1251 EDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290 + GVS++D T + T+P++ ++ + F + I ++ Sbjct: 2135 KYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNL 2174 >gi|189083802 myosin VIIA isoform 2 [Homo sapiens] Length = 2175 Score = 84.7 bits (208), Expect = 5e-16 Identities = 98/377 (25%), Positives = 153/377 (40%), Gaps = 42/377 (11%) Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947 ++ P L+ EIYCQ+ KQ + P K S + W L++LC F P F+ Y++ + H Sbjct: 1162 ILRPALRDEIYCQISKQLT-HNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFI--HG 1218 Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007 P YA YC+ + RT G R PS +E+ + + P +PV F +GT Sbjct: 1219 GPPG----YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDGT 1268 Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFT---DDPSGRDLEHCLQGSVKICD 1064 + D ++T E L +I ++ GF+L+ D S GS + D Sbjct: 1269 TKTLLTDSATTAKELCNALADKISLK--DRFGFSLYIALFDKVSSLG-----SGSDHVMD 1321 Query: 1065 AISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAG 1124 AIS+ EQ KE + R L ++ ++ E + L+ Q R + G Sbjct: 1322 AISQCEQYAKEQGAQERNAPWR---LFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1378 Query: 1125 RFPINKELAL-EMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHG 1183 + KE L E+A+ V+YG S + LL V R Sbjct: 1379 EYRCEKEDDLAELASQQYFVDYG-------------SEMILERLLNLVPTYIPDREITPL 1425 Query: 1184 APAEQLRHLADMLTTKWATLQGCSPPECIR-IYLTVAR-KWPFFGAKLFAAQPAQLSSKE 1241 E+ LA K Q + + ++ ++ AR KWP ++ + A S Sbjct: 1426 KTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLP 1485 Query: 1242 NALVWIAVNEDGVSILD 1258 V +AVN GV +D Sbjct: 1486 KNDVIVAVNWTGVYFVD 1502 Score = 70.9 bits (172), Expect = 8e-12 Identities = 88/400 (22%), Positives = 173/400 (43%), Gaps = 38/400 (9%) Query: 893 LQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSE 952 L+ E Y Q++KQ + +YS + W+LL LC LF P + L +V++ LQ + Sbjct: 1771 LKDEAYVQILKQLTDNHI-RYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSR-----K 1824 Query: 953 TGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1012 A C + +++ LR G R+ P +EV +I H + V+F + T Sbjct: 1825 HCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQ-----HKTTQIFHKVYFPDDTDEAFE 1879 Query: 1013 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQA 1072 + S+ +F Q + + ++ S GF+LF D + + D + Sbjct: 1880 VESSTKAKDFCQNIATRLLLK--SSEGFSLFV---KIADKVLSVPENDFFFDFVRHLTDW 1934 Query: 1073 MKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETD-RERLLLASQTSREIVAGRFPINKE 1131 +K+ P K + ++ + + + V G+ + + Q + + G +E Sbjct: 1935 IKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTRE 1994 Query: 1132 LALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLL-QQVLDRFHPRRYRHGAPAEQLR 1190 L++ AL+ +V++ + +K P + P + L+ Q ++ + P ++ A + Sbjct: 1995 EVLQLGALIYRVKFEE-DKSYFP----SIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNK 2049 Query: 1191 HLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVN 1250 H G S E +L + KWP FG+ F Q + + E ++ IA+N Sbjct: 2050 H------------AGKSKEEAKLAFLKLIFKWPTFGSAFF-EQTTEPNFPE--ILLIAIN 2094 Query: 1251 EDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290 + GVS++D T + T+P++ ++ + F + I ++ Sbjct: 2095 KYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNL 2134 >gi|40255047 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 [Homo sapiens] Length = 793 Score = 78.2 bits (191), Expect = 5e-14 Identities = 117/485 (24%), Positives = 183/485 (37%), Gaps = 78/485 (16%) Query: 798 SSAKVGTAYEQLIGKLMDGEGDPDSPLW---RHPMLCYSKDGLYASLTTLPSEA------ 848 S A + T + L+ + + GDP++ R+P+L ++ LYA L LP Sbjct: 200 SKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPG 259 Query: 849 ---LQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQT 905 L+ EA++LF + Q L Q LQ C P L+ E++ QL KQT Sbjct: 260 YAPLREEAVRLFLALQALEGARRPGP-------LMQGVLQTCRDLPALRDELFLQLAKQT 312 Query: 906 S--CRPP-----QKYSLMQCWQLLALCAPLFLP----QHHFLWYVKQQLQRHADPRSETG 954 S PP Q + ++ WQLL + F P + H L ++++ Q A P SE Sbjct: 313 SGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQ--ALPDSELA 370 Query: 955 QYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFD 1014 +YA + ++A+ RT RE PS E+ ++ R VH V D Sbjct: 371 EYARFIRKALG---RTRGRELVPSLAEISALSQRQ------ELLCTVHCPGAGACAVAID 421 Query: 1015 GSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMK 1074 +T E + L +G+ + S + FAL+ + E L G + D ++++E Sbjct: 422 SHTTAGEVARELVGRLGLAR-SRNAFALYEQRGA---QERALAGGTLVADVLTRFENLAA 477 Query: 1075 ELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELAL 1134 E G + +L + + E L Q ++ GR P + Sbjct: 478 E-EAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLR 536 Query: 1135 EMAALMAQVEYGD-------------LEKPA---------LPGPGGTSPAKAQHLLQQVL 1172 +AAL Q + D L PA P P ++ A L L Sbjct: 537 ALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGL 596 Query: 1173 DRFHPRRYRHGAPAEQLRHL----------ADMLTTKWATLQGCSPPECIRIYLTVARKW 1222 + R R G + A + W L+G E + YL +A + Sbjct: 597 AKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQC 656 Query: 1223 PFFGA 1227 P FGA Sbjct: 657 PGFGA 661 >gi|122937512 myosin VIIB [Homo sapiens] Length = 2116 Score = 72.4 bits (176), Expect = 3e-12 Identities = 91/392 (23%), Positives = 153/392 (39%), Gaps = 50/392 (12%) Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947 ++ P L+ EIYCQ+ KQ S + SL + W LL+LC F P F+ Y+ + + Sbjct: 1101 ILRPSLRDEIYCQICKQLS-ENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQ-- 1157 Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007 Y +C + RT G R P+ +E+ ++ + I V G Sbjct: 1158 ----GPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKK------HIPIQVILATGE 1207 Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFAL-------FTDDPSGRDLEHCLQGSV 1060 V D +ST E + + G+ H GF+L F SGRD Sbjct: 1208 SLTVPVDSASTSREMCMHIAHKQGL--SDHLGFSLQVAVYDKFWSLGSGRD--------- 1256 Query: 1061 KICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSRE 1120 + DAI++ EQ +E + + R+ ++ + E L+ Q R Sbjct: 1257 HMMDAIARCEQMAQERGESQRQSPWRI---YFRKEFFTPWHDSREDPVSTELIYRQVLRG 1313 Query: 1121 IVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRY 1180 + +G + KE E+ L+A+ Y L G ++ +KA +Q++L P + Sbjct: 1314 VWSGEYSFEKE--EELVELLARHCYVQL--------GASAESKA---VQELLPSCIPHKL 1360 Query: 1181 RHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARK--WPFFGAKLFAAQPAQLS 1238 P ++ L K Q P +R + A + WP ++LF Sbjct: 1361 YRTKPPDRWASLVTAACAKAPYTQKQVTPLAVREQVVDAARLQWPLLFSRLFEVITLSGP 1420 Query: 1239 SKENALVWIAVNEDGVSILD-HNTMQVHITYP 1269 + +AVN G+ LD M + +++P Sbjct: 1421 RLPKTQLILAVNWKGLCFLDQQEKMLLELSFP 1452 Score = 69.7 bits (169), Expect = 2e-11 Identities = 83/417 (19%), Positives = 167/417 (40%), Gaps = 38/417 (9%) Query: 877 VSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFL 936 + L + L HP LQ E+YCQ++KQ + ++S + WQLL LC LF P L Sbjct: 1690 LELTDQIFTLALQHPALQDEVYCQILKQLT-HNSNRHSEERGWQLLWLCTGLFPPSKGLL 1748 Query: 937 WYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLP 996 Q+ D R A C R +++ LRTG R+ P ++EV + + Sbjct: 1749 ----PHAQKFIDTR-RGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEA-----AEQNVSR 1798 Query: 997 FSIPVHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALF---TDDPSGRDLE 1053 ++F N T ++ ++ V + + + + S G +LF +D + Sbjct: 1799 ICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQL--ASWEGCSLFIKISDKVISQKEG 1856 Query: 1054 HCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLL 1113 S++ +S W + K G T ++ + +L+ + + + +L Sbjct: 1857 DFFFDSLR---EVSDWVKKNKPQKEGAPV--TLPYQVYFMRKLWLNISPGKDVNADTILH 1911 Query: 1114 ASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLD 1173 Q + + G ++E A+ +A L+ + ++ + P ++L Sbjct: 1912 YHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLASVP-------------KILR 1958 Query: 1174 RFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQ 1233 P +E+ + + + + + E +L +WP FG+ F + Sbjct: 1959 ELVPENLTRLMSSEEWK---KSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVK 2015 Query: 1234 PAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290 S + ++ IA+N GV ++ T + TYP++ ++++ F + + S+ Sbjct: 2016 QTSEPSYPDVIL-IAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSL 2071 >gi|154146216 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 [Homo sapiens] Length = 425 Score = 61.2 bits (147), Expect = 6e-09 Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 12/128 (9%) Query: 561 LQRTSSY-STDGLGLG-GESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIR 618 L+R+ SY T G G L KSGY +K G+ K+WKRR+F L I Y+K D R Sbjct: 179 LRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--R 236 Query: 619 KPQGQVDLNS-----RCQIVRGE---GSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSL 670 +P + L C + G+ F++I+ +T+Y+ ADSP + WI+ + + Sbjct: 237 EPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296 Query: 671 LKVQATGP 678 ++ P Sbjct: 297 VQALKCHP 304 >gi|118402590 myosin XV [Homo sapiens] Length = 3530 Score = 59.3 bits (142), Expect = 2e-08 Identities = 94/460 (20%), Positives = 191/460 (41%), Gaps = 60/460 (13%) Query: 829 MLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFI-NVPVEAASVDYHVSLAQTALQVC 887 MLC++K L SL L +L A +F + F+ + P++ S + + L++C Sbjct: 3047 MLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQS---DLDVLCNLLKLC 3103 Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKY-SLMQCWQLLAL------CAPLFLPQHHFLWYVK 940 H ++ E YCQ++KQ + K S + W+LL + C+ + H L Sbjct: 3104 GDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVL---HPHLTRFL 3160 Query: 941 QQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIP 1000 Q + R P A C++ +++TLR G R PS +E+ ++L L F +P Sbjct: 3161 QDVSR--TPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQL-FLLP 3217 Query: 1001 VHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKP-SHSGFALFTDDPSGRDLEHC-LQG 1058 G + + + ++ + E+ + +P + + + +F G+ + C L Sbjct: 3218 ----GGLERHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHV--CPLSR 3271 Query: 1059 SVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTS 1118 I D S+ EQ +GG +++ R+ + +K E + + +Q Sbjct: 3272 RAYILDVASEMEQV---------DGG----YMLWFRRVLWDQPLKFENELYVTMHYNQVL 3318 Query: 1119 REIVAGRF---PINK--ELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLD 1173 + + G F P ++ E L+ + +A +++ + LP +++V + Sbjct: 3319 PDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDHFYLPS------------VREVQE 3366 Query: 1174 RFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQ 1233 + YR A + L ++++ Q SP + +L + P FG+ F Q Sbjct: 3367 YIPAQLYRTTAGSTWL----NLVSQHRQQTQALSPHQARAQFLGLLSALPMFGSSFFFIQ 3422 Query: 1234 PAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSV 1273 + + +A+N +G++ L T ++ + +P + Sbjct: 3423 SCSNIAVPAPCI-LAINHNGLNFLSTETHELMVKFPLKEI 3461 >gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinositides [Homo sapiens] Length = 280 Score = 59.3 bits (142), Expect = 2e-08 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 7/92 (7%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQ- 639 K GYL K G VKTWK RWF L + ++ Y+K + +P +DL + C V+ + SQ Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFK--DQMSPEPIRILDL-TECSAVQFDYSQE 223 Query: 640 ---TFQLISEKKTYYLTADSPSLLEEWIRVLQ 668 F L+ +T+YL A + +EWI++L+ Sbjct: 224 RVNCFCLVFPFRTFYLCAKTGVEADEWIKILR 255 >gi|50234893 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Homo sapiens] Length = 404 Score = 57.4 bits (137), Expect = 9e-08 Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 8/100 (8%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGS-- 638 K+GY +K G+ +K WKRR+F L + I Y+K S++ ++P + L ++ + S Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFK--SELEKEPLRVIPLKEVHKVQECKQSDI 251 Query: 639 ----QTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQ 674 F++++ +T+Y+ ADSP + WI+ + + Q Sbjct: 252 MMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291 >gi|31377720 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Homo sapiens] Length = 404 Score = 57.4 bits (137), Expect = 9e-08 Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 8/100 (8%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGS-- 638 K+GY +K G+ +K WKRR+F L + I Y+K S++ ++P + L ++ + S Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFK--SELEKEPLRVIPLKEVHKVQECKQSDI 251 Query: 639 ----QTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQ 674 F++++ +T+Y+ ADSP + WI+ + + Q Sbjct: 252 MMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291 >gi|4505531 oxysterol binding protein [Homo sapiens] Length = 807 Score = 54.3 bits (129), Expect = 8e-07 Identities = 36/107 (33%), Positives = 58/107 (54%), Gaps = 6/107 (5%) Query: 571 GLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRC 630 G G GG + G+L K + +K ++RRWFVL G + YY+S +++ +G ++L + Sbjct: 81 GSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATAN 140 Query: 631 QIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLLKVQA 675 V E S F +IS +TY+L A S + W+ L+ L K +A Sbjct: 141 ITV--EDSCNF-IISNGGAQTYHLKASSEVERQRWVTALE-LAKAKA 183 >gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] Length = 698 Score = 54.3 bits (129), Expect = 8e-07 Identities = 42/136 (30%), Positives = 64/136 (47%), Gaps = 24/136 (17%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQT 640 K+G+L K S +K W++RWFVLR Q+ YYK ++ KPQG + L +G+Q Sbjct: 40 KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEI--KPQGFISL---------QGTQV 88 Query: 641 FQLI--SEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVK 698 +L E +L SP E KV A LL ++ ++ W+ ++ Sbjct: 89 TELPPGPEDPGKHLFEISPGGAGE-------REKVPANPEALLLMASSQRDMEDWVQAIR 141 Query: 699 HGHSKVVWCALVGKIF 714 +V+W L G IF Sbjct: 142 ----RVIWAPLGGGIF 153 >gi|93102364 SWAP-70 protein [Homo sapiens] Length = 585 Score = 53.9 bits (128), Expect = 1e-06 Identities = 30/103 (29%), Positives = 52/103 (50%), Gaps = 6/103 (5%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRC---QIVRGEG 637 K GY++K G + K W RWFVL+ I YY S+ ++ +G + L+ C + +G Sbjct: 213 KQGYMMKKGHRRKNWTERWFVLKPNIISYY--VSEDLKDKKGDILLDENCCVESLPDKDG 270 Query: 638 SQTFQLIS-EKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPP 679 + L+ KT+ ++A +EWI+ + S + + G P Sbjct: 271 KKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSP 313 Score = 35.8 bits (81), Expect = 0.29 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 21/179 (11%) Query: 3 ELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELE---QRLLEAE----- 54 E K V+ Q R T+L R +L ++ E +A K ELE QR+ E E Sbjct: 372 EEKKRLQTQVELQAR---FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428 Query: 55 -QRAENAETQVGVMEEKVKLSNLKNVDSEGS----LHRKYQELLKAIKGKDELISQLEAQ 109 Q A E Q EE V+ + ++ E S L + + E +AI+ + +LE Q Sbjct: 429 LQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQ 488 Query: 110 LEKQKQMRAEEAKTVQ----EKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQ 164 ++Q E + ++ E+ ++++ +K KLEM KS ++ G ++ Sbjct: 489 RVLKEQALQEAMEQLEQLELERKQALEQYEEVK-KKLEMATNKTKSWKDKVAHHEGLIR 546 >gi|187608516 centaurin, beta 2 [Homo sapiens] Length = 778 Score = 53.9 bits (128), Expect = 1e-06 Identities = 37/121 (30%), Positives = 57/121 (47%), Gaps = 15/121 (12%) Query: 553 DYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQV-KTWKRRWFVLRQGQIMYYK 611 D+S + KL+ Y+ D + GYL K S KTW RRWF ++ Q++Y K Sbjct: 249 DFSSDDSKLE----YNVDA----ANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK 300 Query: 612 SPSDVIRKPQGQVDLNSRCQIVRGEGSQ---TFQLISEKKTYYLTADSPSLLEEWIRVLQ 668 D P V+ C + E + F+++S K+ L ADS L + WI+ +Q Sbjct: 301 KFKD---NPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQ 357 Query: 669 S 669 + Sbjct: 358 T 358 >gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sapiens] Length = 694 Score = 53.5 bits (127), Expect = 1e-06 Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%) Query: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622 + G + SG+L K + K WKRRWFVLR G++ YYK +D +KP Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58 Query: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667 +DLN Q+ G E S F + + + +YL ADS + +W+R + Sbjct: 59 IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111 >gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sapiens] Length = 724 Score = 53.5 bits (127), Expect = 1e-06 Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%) Query: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622 + G + SG+L K + K WKRRWFVLR G++ YYK +D +KP Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58 Query: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667 +DLN Q+ G E S F + + + +YL ADS + +W+R + Sbjct: 59 IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111 >gi|7661880 centaurin beta1 [Homo sapiens] Length = 740 Score = 53.5 bits (127), Expect = 1e-06 Identities = 35/108 (32%), Positives = 50/108 (46%), Gaps = 12/108 (11%) Query: 574 LGGESLEKS-----------GYLLKMGSQV-KTWKRRWFVLRQGQIMYYKSPSDVIRKPQ 621 LGGE E S G+L K S KTW RRWF ++ Q++Y K D + Sbjct: 250 LGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVV 309 Query: 622 GQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQS 669 + L + E F+++S K+ L ADS LL+ W+ +QS Sbjct: 310 DDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQS 357 >gi|154146189 dedicator of cytokinesis 10 [Homo sapiens] Length = 2186 Score = 53.5 bits (127), Expect = 1e-06 Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 16/146 (10%) Query: 549 SLDSDYSEPEHKLQRTS-SYSTDGLGLGGESLEKSGYLLKMGSQ--------VKTWKRRW 599 S + D+ + + TS S S G G GG + KSG+L K V+++K+R+ Sbjct: 151 SFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRY 210 Query: 600 FVLRQ----GQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQ--TFQLISEKKTYY-L 652 F L Q IM + + ++P+G + L+S +V+ + F+L TY+ L Sbjct: 211 FQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVL 270 Query: 653 TADSPSLLEEWIRVLQSLLKVQATGP 678 A++ S ++EWI L +L++ GP Sbjct: 271 AAETESDMDEWIHTLNRILQISPEGP 296 >gi|194294543 alpha 3 type IV collagen binding protein isoform 3 [Homo sapiens] Length = 752 Score = 52.4 bits (124), Expect = 3e-06 Identities = 42/182 (23%), Positives = 71/182 (39%), Gaps = 4/182 (2%) Query: 502 QASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKL 561 + S + +P + R SP RG+ SS ++EG A L S +++ Sbjct: 79 RTSSLLLLPPTPERALFASPSPDPSPRGLGASSGAAEGAGA----GLLLGCRASMSDNQS 134 Query: 562 QRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQ 621 +S D G +E+ G L K + + W+ RW VL+ + YYKS + + Sbjct: 135 WNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCR 194 Query: 622 GQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPAL 681 G + L+ F + +YL A P ++WI ++ G + Sbjct: 195 GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESS 254 Query: 682 LR 683 LR Sbjct: 255 LR 256 >gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] Length = 397 Score = 52.4 bits (124), Expect = 3e-06 Identities = 29/116 (25%), Positives = 60/116 (51%), Gaps = 26/116 (22%) Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDL------------- 626 ++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L Sbjct: 262 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDSKK 319 Query: 627 ---------NSRCQIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLL 671 +++ Q+++ ++ + E Y ++A +P EEWI+ +++ + Sbjct: 320 PNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375 Score = 35.0 bits (79), Expect = 0.49 Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 9/96 (9%) Query: 655 DSPSLLEEWIRVLQSLLKVQATGPPA-----LLRGGTKPTVKGWLTKVKHGHSKVV---W 706 D L EE +R L +K + P L P +GWL K+ G K W Sbjct: 223 DGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLG-GRVKTWKRRW 281 Query: 707 CALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRS 742 L YY+ DK P G +P+ + I EV+ S Sbjct: 282 FILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS 317 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 52.0 bits (123), Expect = 4e-06 Identities = 34/147 (23%), Positives = 78/147 (53%), Gaps = 8/147 (5%) Query: 13 DWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVK 72 +W+++ ++ Q + R Q KIRE +KM+ E+ + E E++ E + EEK++ Sbjct: 311 EWEEK---IQEQEEKIREQEEKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366 Query: 73 LSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIK 132 + E + R+ + + + K+E I +LE ++ +Q+++R +E K +E+ + + Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422 Query: 133 EWVTLKLAKLEMENQHLKSHNQRLVEQ 159 E + AK+ + + ++ +++ EQ Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQ 449 Score = 42.4 bits (98), Expect = 0.003 Identities = 27/145 (18%), Positives = 74/145 (51%), Gaps = 9/145 (6%) Query: 27 RFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLH 86 + R Q K R+ +KM + E+++ E E++ + E ++ EEK++ + E + Sbjct: 592 KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650 Query: 87 RKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMEN 146 + +++ + ++E + + E + +Q++ E+ K ++E+ KI+E + ++ + Sbjct: 651 EQEEKMCE----QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM----MQEQE 702 Query: 147 QHLKSHNQRLVEQVGSLQDALEAIQ 171 + + +++ EQ +Q+ E ++ Sbjct: 703 EKMWEQEEKMCEQEEKMQEQEEKMR 727 Score = 41.2 bits (95), Expect = 0.007 Identities = 24/122 (19%), Positives = 64/122 (52%), Gaps = 9/122 (7%) Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ---ELLKAIK 97 +K+QE E+++ E E++ E ++ EEK++ + E + R+ + E + ++ Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366 Query: 98 GKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLV 157 ++E++ + E ++ +Q++M E+ + ++E K+ E ++ E + + +++ Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR------EQEEKRQEEEKIR 420 Query: 158 EQ 159 EQ Sbjct: 421 EQ 422 Score = 40.8 bits (94), Expect = 0.009 Identities = 30/139 (21%), Positives = 67/139 (48%), Gaps = 6/139 (4%) Query: 36 RELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSL---HRKYQEL 92 R+ DKM E+++ E E++ E ++ EEK + K E + K QE Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624 Query: 93 LKAIKGKDELISQLEAQLEKQKQMRAEEAKTV---QEKAAKIKEWVTLKLAKLEMENQHL 149 + I+ ++E I + E ++Q++ E+ + + +EK + +E + + K+ + + + Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684 Query: 150 KSHNQRLVEQVGSLQDALE 168 + +++ EQ +Q+ E Sbjct: 685 REQEEKIREQEEMMQEQEE 703 Score = 36.6 bits (83), Expect = 0.17 Identities = 24/105 (22%), Positives = 56/105 (53%), Gaps = 5/105 (4%) Query: 33 SKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQEL 92 +++ + +KM E+++ E E++ + E ++ EEK++ K E + K +++ Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351 Query: 93 LK----AIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133 + + ++++ Q E EK+++MR +E + + EK KI+E Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRE 395 Score = 33.9 bits (76), Expect = 1.1 Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 2/138 (1%) Query: 34 KIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELL 93 KIREL +KM E E+ + E+R E + + ++ + + + K +E Sbjct: 392 KIREL-EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450 Query: 94 KAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHN 153 K + ++E I + E E++K+ EE +EK + +E + + K+ + + ++ Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE-QEEIWRQKEKMHEQEEKIRKQE 509 Query: 154 QRLVEQVGSLQDALEAIQ 171 +++ Q +++ E I+ Sbjct: 510 EKVWRQEEKIREQEEKIR 527 Score = 33.9 bits (76), Expect = 1.1 Identities = 17/93 (18%), Positives = 49/93 (52%), Gaps = 4/93 (4%) Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKD 100 +KMQE E+ + E++ E ++ EEK++ + E + + +++ + ++ Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE----QE 716 Query: 101 ELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133 E + + E ++ +Q++ E+ ++++ K++E Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749 Score = 32.7 bits (73), Expect = 2.4 Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 19/120 (15%) Query: 29 RLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKV-----KLSNLKNVDSEG 83 R + KIRE +K QE E ++ E++ E ++ E+K+ K+ + + E Sbjct: 413 RQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 470 Query: 84 SLHRKYQELL----KAIKGKDELISQLEAQLEKQKQMRAEEAKT------VQEKAAKIKE 133 R+ QE + + I ++E+ Q E E+++++R +E K ++E+ KI+E Sbjct: 471 K--RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528 Score = 32.7 bits (73), Expect = 2.4 Identities = 18/87 (20%), Positives = 47/87 (54%), Gaps = 3/87 (3%) Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKD 100 +KM E E+++ E E+ E ++ E+K++ K + E + + +++ + ++ Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ---EE 710 Query: 101 ELISQLEAQLEKQKQMRAEEAKTVQEK 127 ++ Q E E++++MR +E K +++ Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQE 737 Score = 32.0 bits (71), Expect = 4.2 Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 19/131 (14%) Query: 19 LTLETQLFRFRLQASKIR-ELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLK 77 LT E L + I E L +K +L+++L E +E +E Q+ V E K KL K Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE--SEKSEIQLNVKELKRKLERAK 255 Query: 78 NVDSEGSLHRKYQELLKAIKG----------KDELISQLEAQLEKQKQMRAEEA-----K 122 + + L + L K ++ ++EL ++L Q E +K R EE + Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE-EKMWRQEEKIQEWEE 314 Query: 123 TVQEKAAKIKE 133 +QE+ KI+E Sbjct: 315 KIQEQEEKIRE 325 >gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] Length = 399 Score = 52.0 bits (123), Expect = 4e-06 Identities = 30/118 (25%), Positives = 60/118 (50%), Gaps = 26/118 (22%) Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDL------------- 626 ++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L Sbjct: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVDDPRK 318 Query: 627 ---------NSRCQIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLLKV 673 N++ Q+++ ++ + E Y ++A + +EWI+ +Q+ + V Sbjct: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 376 Score = 38.5 bits (88), Expect = 0.044 Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 14/133 (10%) Query: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD--RS 742 P +GWL K+ G K W L YY+ DK P G +P+ + I EVD R Sbjct: 260 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRK 318 Query: 743 CDSDEDYEAGGTRRLLSSHCTLV---IHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSS 799 + E Y +L+ + T + H + T+ EKD W+ + A Sbjct: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAA----- 373 Query: 800 AKVGTAYEQLIGK 812 V YE L + Sbjct: 374 VSVDPFYEMLAAR 386 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 51.2 bits (121), Expect = 7e-06 Identities = 45/184 (24%), Positives = 88/184 (47%), Gaps = 19/184 (10%) Query: 17 RCLTLETQLFRFRLQASKIRELLADKMQ-------ELEQRLLEAEQRAENAETQVGVMEE 69 R + LE + + ++ + E+L + Q EL Q+L ++ E + +V EE Sbjct: 1526 RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE 1585 Query: 70 KVKLSNLKNVDSEGSLHRKYQELLK---AIKGKDELISQLEAQLEKQKQMR-AEEAKTVQ 125 K+ + + L K +EL ++K K+E + LE +LE + + AE + + Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE 1645 Query: 126 EKAAKIKEWVTLKLAKLEME-----NQHLKSHNQRLVE---QVGSLQDALEAIQIAPSRK 177 +K A IK+ + ++ + E + HL N +L E +V L++ L++++ + S Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSET 1705 Query: 178 LLVP 181 L+VP Sbjct: 1706 LIVP 1709 Score = 39.3 bits (90), Expect = 0.026 Identities = 38/172 (22%), Positives = 75/172 (43%), Gaps = 10/172 (5%) Query: 15 QKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLS 74 Q++ L LET+ Q +++ D EL+ ++ + + E Q ME+KVK S Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK-S 883 Query: 75 NLKNVDSEGSLHRKYQELLKAI-KGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133 + +S+ K QE K I K+ +I Q+ +K+ ++ ++ ++ + E Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943 Query: 134 WVTLKLAKLEMENQHLKSH--------NQRLVEQVGSLQDALEAIQIAPSRK 177 K E + + +K ++L++Q L+ LE + S+K Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995 Score = 35.8 bits (81), Expect = 0.29 Identities = 39/193 (20%), Positives = 90/193 (46%), Gaps = 24/193 (12%) Query: 14 WQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQ---RAENAETQVGVMEE- 69 W ++ L+ Q ++ + K+RE K ++ ++ LL+ ++ +A E +E+ Sbjct: 627 WTEKLQVLKQQ---YQTEMEKLRE----KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679 Query: 70 KVKLSNLKNVDSEGS----LHRKYQELLKAIKGK-DELISQLEAQLEKQKQMRAEEAK-- 122 VK + L+++ SE S K +E L +K + D++ +LEA++++QK ++ Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739 Query: 123 ------TVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSR 176 ++Q +K+ + L+ ++HLK H + ++ + +Q A ++ Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799 Query: 177 KLLVPPYGAAEQD 189 + Y +A + Sbjct: 800 LDVFQSYQSATHE 812 Score = 32.0 bits (71), Expect = 4.2 Identities = 45/161 (27%), Positives = 74/161 (45%), Gaps = 24/161 (14%) Query: 20 TLETQLFRFRLQ-ASKIREL------LADKMQELEQRLLEAEQRAENAETQVGVMEEKVK 72 TL+ + F Q A K +EL +K QE+E LLE+ Q ET + + K Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE----ETNQLLKKIAEK 2048 Query: 73 LSNLKNVDSEGSLHRKYQELLKAIKGK-----DELISQLEAQLEKQKQMRAEEAKTVQEK 127 +LK ++Y+E+L A + + +L +QLE +L+K+ Q + E+ + Sbjct: 2049 DDDLKRT------AKRYEEILDAREEEMTAKVRDLQTQLE-ELQKKYQQKLEQEENPGND 2101 Query: 128 AAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALE 168 I E T +LA+ K Q EQ+ +L+D L+ Sbjct: 2102 NVTIMELQT-QLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141 >gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [Homo sapiens] Length = 834 Score = 51.2 bits (121), Expect = 7e-06 Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 1/88 (1%) Query: 583 GYLLKMGSQV-KTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTF 641 GYL K S KTW RRWF ++ Q++Y K D + + L S E F Sbjct: 273 GYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCF 332 Query: 642 QLISEKKTYYLTADSPSLLEEWIRVLQS 669 +++S K+ L ADS L + W++ +Q+ Sbjct: 333 EVLSPTKSCMLQADSEKLRQAWVQAVQA 360 >gi|4758968 cytohesin 3 [Homo sapiens] Length = 399 Score = 51.2 bits (121), Expect = 7e-06 Identities = 29/114 (25%), Positives = 58/114 (50%), Gaps = 26/114 (22%) Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNS----------- 628 ++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L + Sbjct: 266 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDPRK 323 Query: 629 -----------RCQIVRGEGSQTFQLISEKK--TYYLTADSPSLLEEWIRVLQS 669 + Q+++ ++ + E Y ++A SP EEW++ +++ Sbjct: 324 PNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKA 377 Score = 33.5 bits (75), Expect = 1.4 Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 4/56 (7%) Query: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD 740 P +GWL K+ G K W L YY+ DK P G +P+ + I EV+ Sbjct: 265 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE 319 >gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sapiens] Length = 645 Score = 51.2 bits (121), Expect = 7e-06 Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 17/102 (16%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQI------VR 634 K G+L K S VK W++R+FVLR Q+ YYK D KPQG + L C I Sbjct: 49 KMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDT--KPQGCMYLPG-CTIKEIATNPE 105 Query: 635 GEGSQTFQLISE--------KKTYYLTADSPSLLEEWIRVLQ 668 G F++I + +Y L A S + +EEW++ L+ Sbjct: 106 EAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 147 Score = 33.1 bits (74), Expect = 1.9 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 6/57 (10%) Query: 687 KPTVKGWLTK----VKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEV 739 +P GWL K VK+ + + L + YYY+ ED +P GC+ + I+E+ Sbjct: 46 RPIKMGWLKKQRSIVKNWQQR--YFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 100 >gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapiens] Length = 638 Score = 51.2 bits (121), Expect = 7e-06 Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 17/102 (16%) Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQI------VR 634 K G+L K S VK W++R+FVLR Q+ YYK D KPQG + L C I Sbjct: 42 KMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDT--KPQGCMYLPG-CTIKEIATNPE 98 Query: 635 GEGSQTFQLISE--------KKTYYLTADSPSLLEEWIRVLQ 668 G F++I + +Y L A S + +EEW++ L+ Sbjct: 99 EAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 140 Score = 33.1 bits (74), Expect = 1.9 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 6/57 (10%) Query: 687 KPTVKGWLTK----VKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEV 739 +P GWL K VK+ + + L + YYY+ ED +P GC+ + I+E+ Sbjct: 39 RPIKMGWLKKQRSIVKNWQQR--YFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 93 >gi|58331179 KIAA1688 protein [Homo sapiens] Length = 1114 Score = 50.8 bits (120), Expect = 9e-06 Identities = 37/125 (29%), Positives = 65/125 (52%), Gaps = 4/125 (3%) Query: 829 MLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCL 888 ML +S + + + ++ EA +LFK Q+++ A + HV+L + A + Sbjct: 719 MLAWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMG-DRRAKADPLHVAL-EVATKGWS 776 Query: 889 VHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHAD 948 V L+ E+Y QL +QT+ + SL + W+L+A+C F P F Y++ + RH D Sbjct: 777 VQG-LRDELYIQLCRQTT-ENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMD 834 Query: 949 PRSET 953 P ++T Sbjct: 835 PVNDT 839 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.131 0.388 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 58,064,745 Number of Sequences: 37866 Number of extensions: 2880509 Number of successful extensions: 15039 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 150 Number of HSP's successfully gapped in prelim test: 724 Number of HSP's that attempted gapping in prelim test: 12087 Number of HSP's gapped (non-prelim): 3043 length of query: 1364 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1249 effective length of database: 13,892,928 effective search space: 17352267072 effective search space used: 17352267072 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.