Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 55741447
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741447 pleckstrin homology domain containing, family H
(with MyTH4 domain) member 1 [Homo sapiens]
(1364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741447 pleckstrin homology domain containing, family H (wit... 2748 0.0
gi|217416392 pleckstrin homology domain containing, family H (wi... 1174 0.0
gi|154354979 myosin X [Homo sapiens] 113 1e-24
gi|189083798 myosin VIIA isoform 1 [Homo sapiens] 85 4e-16
gi|189083802 myosin VIIA isoform 2 [Homo sapiens] 85 5e-16
gi|40255047 pleckstrin homology domain containing, family H (wit... 78 5e-14
gi|122937512 myosin VIIB [Homo sapiens] 72 3e-12
gi|154146216 pleckstrin homology domain containing, family A (ph... 61 6e-09
gi|118402590 myosin XV [Homo sapiens] 59 2e-08
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 59 2e-08
gi|50234893 pleckstrin homology domain containing, family A (pho... 57 9e-08
gi|31377720 pleckstrin homology domain containing, family A (pho... 57 9e-08
gi|4505531 oxysterol binding protein [Homo sapiens] 54 8e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 54 8e-07
gi|93102364 SWAP-70 protein [Homo sapiens] 54 1e-06
gi|187608516 centaurin, beta 2 [Homo sapiens] 54 1e-06
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 54 1e-06
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 54 1e-06
gi|7661880 centaurin beta1 [Homo sapiens] 54 1e-06
gi|154146189 dedicator of cytokinesis 10 [Homo sapiens] 54 1e-06
gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ... 52 3e-06
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 52 3e-06
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 52 4e-06
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 52 4e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 51 7e-06
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 51 7e-06
gi|4758968 cytohesin 3 [Homo sapiens] 51 7e-06
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 51 7e-06
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 51 7e-06
gi|58331179 KIAA1688 protein [Homo sapiens] 51 9e-06
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 2748 bits (7123), Expect = 0.0
Identities = 1364/1364 (100%), Positives = 1364/1364 (100%)
Query: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60
MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA
Sbjct: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60
Query: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120
ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE
Sbjct: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120
Query: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180
AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV
Sbjct: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV 180
Query: 181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS 240
PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS
Sbjct: 181 PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSS 240
Query: 241 SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS 300
SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS
Sbjct: 241 SSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGTKTS 300
Query: 301 AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG 360
AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG
Sbjct: 301 AREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG 360
Query: 361 LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS 420
LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS
Sbjct: 361 LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSS 420
Query: 421 WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA 480
WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA
Sbjct: 421 WESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKGRA 480
Query: 481 TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD 540
TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD
Sbjct: 481 TQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGD 540
Query: 541 YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF 600
YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF
Sbjct: 541 YAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWF 600
Query: 601 VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL 660
VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL
Sbjct: 601 VLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLL 660
Query: 661 EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH 720
EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH
Sbjct: 661 EEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSH 720
Query: 721 EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT 780
EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT
Sbjct: 721 EDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGT 780
Query: 781 KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS 840
KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS
Sbjct: 781 KHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLYAS 840
Query: 841 LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ 900
LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ
Sbjct: 841 LTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQ 900
Query: 901 LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC 960
LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC
Sbjct: 901 LMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYATYC 960
Query: 961 QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD 1020
QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD
Sbjct: 961 QRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVD 1020
Query: 1021 EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK 1080
EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK
Sbjct: 1021 EFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGK 1080
Query: 1081 SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM 1140
SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM
Sbjct: 1081 SEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALM 1140
Query: 1141 AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW 1200
AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW
Sbjct: 1141 AQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADMLTTKW 1200
Query: 1201 ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN 1260
ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN
Sbjct: 1201 ATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSILDHN 1260
Query: 1261 TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA 1320
TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA
Sbjct: 1261 TMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEATFIMA 1320
Query: 1321 SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364
SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL
Sbjct: 1321 SYMNHCTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 1174 bits (3038), Expect = 0.0
Identities = 609/1080 (56%), Positives = 780/1080 (72%), Gaps = 39/1080 (3%)
Query: 306 PGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELE 365
P S L PK+R P S+ LAKRH SQPQ+ R+ A S + P E +
Sbjct: 432 PSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSD---RMFGTNRNAISMIRPLRPQETD 488
Query: 366 SR---ARSREEPEKMEMEEPPPAGKNEERESPKALGAE----LEEVELGNKPPTPPLHQF 418
S E E M+ + +SP + E ++V +KPPTPPLH+F
Sbjct: 489 LDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAY-SKPPTPPLHRF 547
Query: 419 SSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKG 478
SWESRIYAVA SG+R+S+ + +++ + + G ++ L+YKN+T PVYT LKG
Sbjct: 548 PSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKG 607
Query: 479 RATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSE 538
+ATQIS+ PF+D+SSGS+++ SS++S R S S+SR SG GSPRA+KRGVS+SS++SE
Sbjct: 608 KATQISSSPFLDDSSGSEEEDSSRSSSRTS--ESDSRSRSGPGSPRAMKRGVSLSSVASE 665
Query: 539 GDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRR 598
DYAIPPDA S D++YS+PE KL +T S S+D E LEKSGYLLKM +VK+WKRR
Sbjct: 666 SDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGK--NEPLEKSGYLLKMSGKVKSWKRR 723
Query: 599 WFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPS 658
WFVL+ G+++YYKSPSDVIRKPQG ++L++ C I+RG+ QT QL +EK TYYLTADSP+
Sbjct: 724 WFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPN 783
Query: 659 LLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYR 718
+LEEWI+VLQ++L+VQA P +L G KPT+KG LTKVKHG+SK VWC L+GK YY+R
Sbjct: 784 ILEEWIKVLQNVLRVQAANPLSLQPEG-KPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFR 842
Query: 719 SHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLI 778
S EDK PLG + + +A +EEVDRSCDSDEDYEA G R LLS+H T+VIHP + PTYLLI
Sbjct: 843 SQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASG-RSLLSTHYTIVIHPKDQGPTYLLI 901
Query: 779 GTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLY 838
G+KHEKDTWLYHLTVAAG ++ VG+ +EQL+ KL++ +G+P S +WRHP LC+SK+G+
Sbjct: 902 GSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGII 961
Query: 839 ASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIY 898
+ LTTLPSEALQTEA+KLFK+CQLFIN V++ ++DYH+SLAQ+ALQ+CL HPELQ+EI
Sbjct: 962 SPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEIC 1021
Query: 899 CQLMKQTSCRPPQKY-SLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYA 957
CQL+KQT R PQ +Q WQLLALC LFLP H FLW ++ L+R+AD R+E G+YA
Sbjct: 1022 CQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYA 1081
Query: 958 TYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSS 1017
YCQR VERT + G+REARPSRME++S LLRNP+HHSLPFSIPVHF NG Y VVGFD S+
Sbjct: 1082 IYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAST 1141
Query: 1018 TVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELH 1077
TV+EFL LNQ+ GMRKP+ SGFALFTDDPSGRDLEHCLQG++KICD ISKWEQA KE
Sbjct: 1142 TVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQ 1201
Query: 1078 PGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMA 1137
PGK E GTR V+L YKNRLYF Q +GETDRE+LLL QT+ +I+ G FP+NK+LALEMA
Sbjct: 1202 PGKCE-GTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA 1260
Query: 1138 ALMAQVEYGDLEKP-ALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML 1196
AL++QVE GD E+P + P T+ K L+QV+++F+P+RYR G EQLR L L
Sbjct: 1261 ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL 1320
Query: 1197 TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSI 1256
+T+W L+G S +C+RIYLTVARKWPFFGAKLF A+P SS + +W+AV+EDG+S+
Sbjct: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL 1380
Query: 1257 LDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEAT 1316
L++N+M++ ++Y Y S+ TFGG +DDFM+VI + K EKL+F MA PKI E T
Sbjct: 1381 LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKD---KPTEKLLFAMAKPKILEIT 1437
Query: 1317 FIMASYMNH------------CTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364
++ASY+N+ ++ T P A + G Q S S TKGPTLL
Sbjct: 1438 LLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQA----RMMGSQPLLSSSRPTKGPTLL 1493
Score = 181 bits (459), Expect = 4e-45
Identities = 91/171 (53%), Positives = 133/171 (77%), Gaps = 1/171 (0%)
Query: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60
MAEL E VDW++RC+ LE+QL +FR+QASKIRELLA+KMQ+LE+++++AE++AE A
Sbjct: 1 MAELS-EPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKA 59
Query: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120
QV VME+K+K +N++ +SE L+ K Q+L I+ KD++I LE QLE+QKQ+R +E
Sbjct: 60 FQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQE 119
Query: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQ 171
AK ++EKAAKIKEWVT+KL +LE+ENQ+L+ NQ E++ ++Q L+ +Q
Sbjct: 120 AKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQ 170
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 113 bits (282), Expect = 1e-24
Identities = 157/708 (22%), Positives = 276/708 (38%), Gaps = 98/708 (13%)
Query: 626 LNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQ-SLLKVQATGPPALLRG 684
++S C + +F +I+ + + AD+P + WI +LQ S + G ++RG
Sbjct: 1338 IDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQEFIVRG 1397
Query: 685 GTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYRSHEDKR-PLGCLPVRD-AHIEEVDRS 742
VK K+ K W L YY+S E LG L + + D
Sbjct: 1398 WLHKEVKN-SPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEK 1456
Query: 743 CDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSSAKV 802
+ Y HC + + T ++ DT A +
Sbjct: 1457 IFKETGY--WNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDT------------KAPI 1502
Query: 803 GTAYEQLIGKLMDG--EGDPDSPLW-RHPMLCYSKDGLYASLTTLPS------------- 846
T +QLI + + D ++ R+P+L Y+ L++ L LP
Sbjct: 1503 DTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGY 1562
Query: 847 EALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQTS 906
LQ EA+K+F S Q + S+ + + Q LQ L+ E+YCQL+KQT+
Sbjct: 1563 TTLQDEAIKIFNSLQ-------QLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTN 1615
Query: 907 CRP-PQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHAD--PRSETGQYATYCQRA 963
P P + WQ+L + FLP L Y+K L+R + P SE +YA + +
Sbjct: 1616 KVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYES 1675
Query: 964 VERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSSTVDEFL 1023
+++T RE PSR E+ +++ H + V+ G + + +T E +
Sbjct: 1676 LKKTKC---REFVPSRDEIEALI------HRQEMTSTVYCHGGGSCKITINSHTTAGEVV 1726
Query: 1024 QRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELHPGKSEG 1083
++L + + M + S + FALF + +G ++ ++ + D ++K+E+ SE
Sbjct: 1727 EKLIRGLAM-EDSRNMFALF--EYNGH-VDKAIESRTVVADVLAKFEKL-----AATSEV 1777
Query: 1084 GTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMAALMAQV 1143
G K +K + + + E + Q ++ G P +E +AAL Q
Sbjct: 1778 GDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQY 1837
Query: 1144 EYGD--LEKPALPGPGGTSPAKAQHLLQQVLDRFHP-----------------RRYRHGA 1184
GD L P S + + + Q F P R +R G+
Sbjct: 1838 LQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGS 1897
Query: 1185 PAEQL---RHLADM------------LTTKWATLQGCSPPECIRIYLTVARKWPFFGAKL 1229
Q + DM + KW QG + + + Y+ + ++WP +G+ L
Sbjct: 1898 VVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTL 1957
Query: 1230 FAAQPAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFG 1277
F + + + +W+ V+ D VS+ + + Y + +FG
Sbjct: 1958 FDVECKEGGFPQE--LWLGVSADAVSVYKRGEGRPLEVFQYEHILSFG 2003
Score = 57.0 bits (136), Expect = 1e-07
Identities = 31/96 (32%), Positives = 53/96 (55%), Gaps = 8/96 (8%)
Query: 581 KSGYLLKMGSQVKT-----WKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRG 635
K G+L K G T WK+RWFVLRQ ++MY+++ S+ K +G V++ + +I+
Sbjct: 1215 KQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSE--EKLKGTVEVRTAKEIIDN 1272
Query: 636 EGSQT-FQLISEKKTYYLTADSPSLLEEWIRVLQSL 670
+ +I +T++L A+SP +W VL +
Sbjct: 1273 TTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQV 1308
Score = 36.2 bits (82), Expect = 0.22
Identities = 35/159 (22%), Positives = 76/159 (47%), Gaps = 5/159 (3%)
Query: 15 QKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLS 74
+K + + QL R ++ R+LLA+K ++ E++ E E++ + E + E + + +
Sbjct: 789 KKAAIVFQKQL-RGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEE-RERERERREA 846
Query: 75 NLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEW 134
L+ E + ++ E L+ + + EL +LE Q E ++ + E ++KE
Sbjct: 847 ELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQ 906
Query: 135 VTLKLAKLEMEN-QHLKSHNQRLVEQVG--SLQDALEAI 170
L L + ++ Q + R +E+ + Q+ LE++
Sbjct: 907 QELSLTEASLQKLQERRDQELRRLEEEACRAAQEFLESL 945
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/87 (27%), Positives = 36/87 (41%), Gaps = 8/87 (9%)
Query: 596 KRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIV-------RGEGSQTFQLISEKK 648
K+RWFVL + YYKS S+ G + LNS C +V + G + K
Sbjct: 1415 KKRWFVLTHNSLDYYKS-SEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKH 1473
Query: 649 TYYLTADSPSLLEEWIRVLQSLLKVQA 675
Y L + W +Q++ +A
Sbjct: 1474 CYRLYTKLLNEATRWSSAIQNVTDTKA 1500
>gi|189083798 myosin VIIA isoform 1 [Homo sapiens]
Length = 2215
Score = 85.1 bits (209), Expect = 4e-16
Identities = 102/401 (25%), Positives = 165/401 (41%), Gaps = 44/401 (10%)
Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947
++ P L+ EIYCQ+ KQ + P K S + W L++LC F P F+ Y++ + H
Sbjct: 1162 ILRPALRDEIYCQISKQLT-HNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFI--HG 1218
Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007
P YA YC+ + RT G R PS +E+ + + P +PV F +GT
Sbjct: 1219 GPPG----YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDGT 1268
Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFT---DDPSGRDLEHCLQGSVKICD 1064
+ D ++T E L +I ++ GF+L+ D S GS + D
Sbjct: 1269 TKTLLTDSATTAKELCNALADKISLK--DRFGFSLYIALFDKVSSLG-----SGSDHVMD 1321
Query: 1065 AISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAG 1124
AIS+ EQ KE + R L ++ ++ E + L+ Q R + G
Sbjct: 1322 AISQCEQYAKEQGAQERNAPWR---LFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1378
Query: 1125 RFPINKELAL-EMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHG 1183
+ KE L E+A+ V+YG S + LL V R
Sbjct: 1379 EYRCEKEDDLAELASQQYFVDYG-------------SEMILERLLNLVPTYIPDREITPL 1425
Query: 1184 APAEQLRHLADMLTTKWATLQGCSPPECIR-IYLTVAR-KWPFFGAKLFAAQPAQLSSKE 1241
E+ LA K Q + + ++ ++ AR KWP ++ + A S
Sbjct: 1426 KTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLP 1485
Query: 1242 NALVWIAVNEDGVSILD-HNTMQVHITYP-YSSVTTFGGCR 1280
V +AVN GV +D + + +++P +V++ CR
Sbjct: 1486 KNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECR 1526
Score = 71.6 bits (174), Expect = 5e-12
Identities = 87/400 (21%), Positives = 171/400 (42%), Gaps = 36/400 (9%)
Query: 893 LQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSE 952
L+ E Y Q++KQ + +YS + W+LL LC LF P + L +V++ LQ +
Sbjct: 1809 LKDEAYVQILKQLTDNHI-RYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSR-----K 1862
Query: 953 TGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1012
A C + +++ LR G R+ P +EV +I H + V+F + T
Sbjct: 1863 HCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQ-----HKTTQIFHKVYFPDDTDEAFE 1917
Query: 1013 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQA 1072
+ S+ +F Q + + ++ S GF+LF D + + D +
Sbjct: 1918 VESSTKAKDFCQNIATRLLLK--SSEGFSLFV---KIADKVLSVPENDFFFDFVRHLTDW 1972
Query: 1073 MKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETD-RERLLLASQTSREIVAGRFPINKE 1131
+K+ P K + ++ + + + V G+ + + Q + + G +E
Sbjct: 1973 IKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTRE 2032
Query: 1132 LALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLL-QQVLDRFHPRRYRHGAPAEQLR 1190
L++ AL+ +V++ + +K P + P + L+ Q ++ + P ++ A +
Sbjct: 2033 EVLQLGALIYRVKFEE-DKSYFP----SIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNK 2087
Query: 1191 HLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVN 1250
H G S E +L + KWP FG+ F + + L+ IA+N
Sbjct: 2088 H------------AGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILL-IAIN 2134
Query: 1251 EDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290
+ GVS++D T + T+P++ ++ + F + I ++
Sbjct: 2135 KYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNL 2174
>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
Length = 2175
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/377 (25%), Positives = 153/377 (40%), Gaps = 42/377 (11%)
Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947
++ P L+ EIYCQ+ KQ + P K S + W L++LC F P F+ Y++ + H
Sbjct: 1162 ILRPALRDEIYCQISKQLT-HNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFI--HG 1218
Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007
P YA YC+ + RT G R PS +E+ + + P +PV F +GT
Sbjct: 1219 GPPG----YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDGT 1268
Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALFT---DDPSGRDLEHCLQGSVKICD 1064
+ D ++T E L +I ++ GF+L+ D S GS + D
Sbjct: 1269 TKTLLTDSATTAKELCNALADKISLK--DRFGFSLYIALFDKVSSLG-----SGSDHVMD 1321
Query: 1065 AISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAG 1124
AIS+ EQ KE + R L ++ ++ E + L+ Q R + G
Sbjct: 1322 AISQCEQYAKEQGAQERNAPWR---LFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1378
Query: 1125 RFPINKELAL-EMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHG 1183
+ KE L E+A+ V+YG S + LL V R
Sbjct: 1379 EYRCEKEDDLAELASQQYFVDYG-------------SEMILERLLNLVPTYIPDREITPL 1425
Query: 1184 APAEQLRHLADMLTTKWATLQGCSPPECIR-IYLTVAR-KWPFFGAKLFAAQPAQLSSKE 1241
E+ LA K Q + + ++ ++ AR KWP ++ + A S
Sbjct: 1426 KTLEKWAQLAIAAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLP 1485
Query: 1242 NALVWIAVNEDGVSILD 1258
V +AVN GV +D
Sbjct: 1486 KNDVIVAVNWTGVYFVD 1502
Score = 70.9 bits (172), Expect = 8e-12
Identities = 88/400 (22%), Positives = 173/400 (43%), Gaps = 38/400 (9%)
Query: 893 LQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSE 952
L+ E Y Q++KQ + +YS + W+LL LC LF P + L +V++ LQ +
Sbjct: 1771 LKDEAYVQILKQLTDNHI-RYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSR-----K 1824
Query: 953 TGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVG 1012
A C + +++ LR G R+ P +EV +I H + V+F + T
Sbjct: 1825 HCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQ-----HKTTQIFHKVYFPDDTDEAFE 1879
Query: 1013 FDGSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQA 1072
+ S+ +F Q + + ++ S GF+LF D + + D +
Sbjct: 1880 VESSTKAKDFCQNIATRLLLK--SSEGFSLFV---KIADKVLSVPENDFFFDFVRHLTDW 1934
Query: 1073 MKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETD-RERLLLASQTSREIVAGRFPINKE 1131
+K+ P K + ++ + + + V G+ + + Q + + G +E
Sbjct: 1935 IKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTRE 1994
Query: 1132 LALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLL-QQVLDRFHPRRYRHGAPAEQLR 1190
L++ AL+ +V++ + +K P + P + L+ Q ++ + P ++ A +
Sbjct: 1995 EVLQLGALIYRVKFEE-DKSYFP----SIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNK 2049
Query: 1191 HLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVN 1250
H G S E +L + KWP FG+ F Q + + E ++ IA+N
Sbjct: 2050 H------------AGKSKEEAKLAFLKLIFKWPTFGSAFF-EQTTEPNFPE--ILLIAIN 2094
Query: 1251 EDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290
+ GVS++D T + T+P++ ++ + F + I ++
Sbjct: 2095 KYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNL 2134
>gi|40255047 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 3 [Homo sapiens]
Length = 793
Score = 78.2 bits (191), Expect = 5e-14
Identities = 117/485 (24%), Positives = 183/485 (37%), Gaps = 78/485 (16%)
Query: 798 SSAKVGTAYEQLIGKLMDGEGDPDSPLW---RHPMLCYSKDGLYASLTTLPSEA------ 848
S A + T + L+ + + GDP++ R+P+L ++ LYA L LP
Sbjct: 200 SKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPG 259
Query: 849 ---LQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQT 905
L+ EA++LF + Q L Q LQ C P L+ E++ QL KQT
Sbjct: 260 YAPLREEAVRLFLALQALEGARRPGP-------LMQGVLQTCRDLPALRDELFLQLAKQT 312
Query: 906 S--CRPP-----QKYSLMQCWQLLALCAPLFLP----QHHFLWYVKQQLQRHADPRSETG 954
S PP Q + ++ WQLL + F P + H L ++++ Q A P SE
Sbjct: 313 SGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQ--ALPDSELA 370
Query: 955 QYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFD 1014
+YA + ++A+ RT RE PS E+ ++ R VH V D
Sbjct: 371 EYARFIRKALG---RTRGRELVPSLAEISALSQRQ------ELLCTVHCPGAGACAVAID 421
Query: 1015 GSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMK 1074
+T E + L +G+ + S + FAL+ + E L G + D ++++E
Sbjct: 422 SHTTAGEVARELVGRLGLAR-SRNAFALYEQRGA---QERALAGGTLVADVLTRFENLAA 477
Query: 1075 ELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELAL 1134
E G + +L + + E L Q ++ GR P +
Sbjct: 478 E-EAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLR 536
Query: 1135 EMAALMAQVEYGD-------------LEKPA---------LPGPGGTSPAKAQHLLQQVL 1172
+AAL Q + D L PA P P ++ A L L
Sbjct: 537 ALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGL 596
Query: 1173 DRFHPRRYRHGAPAEQLRHL----------ADMLTTKWATLQGCSPPECIRIYLTVARKW 1222
+ R R G + A + W L+G E + YL +A +
Sbjct: 597 AKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQC 656
Query: 1223 PFFGA 1227
P FGA
Sbjct: 657 PGFGA 661
>gi|122937512 myosin VIIB [Homo sapiens]
Length = 2116
Score = 72.4 bits (176), Expect = 3e-12
Identities = 91/392 (23%), Positives = 153/392 (39%), Gaps = 50/392 (12%)
Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHA 947
++ P L+ EIYCQ+ KQ S + SL + W LL+LC F P F+ Y+ + +
Sbjct: 1101 ILRPSLRDEIYCQICKQLS-ENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQ-- 1157
Query: 948 DPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGT 1007
Y +C + RT G R P+ +E+ ++ + I V G
Sbjct: 1158 ----GPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKK------HIPIQVILATGE 1207
Query: 1008 YHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFAL-------FTDDPSGRDLEHCLQGSV 1060
V D +ST E + + G+ H GF+L F SGRD
Sbjct: 1208 SLTVPVDSASTSREMCMHIAHKQGL--SDHLGFSLQVAVYDKFWSLGSGRD--------- 1256
Query: 1061 KICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSRE 1120
+ DAI++ EQ +E + + R+ ++ + E L+ Q R
Sbjct: 1257 HMMDAIARCEQMAQERGESQRQSPWRI---YFRKEFFTPWHDSREDPVSTELIYRQVLRG 1313
Query: 1121 IVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLDRFHPRRY 1180
+ +G + KE E+ L+A+ Y L G ++ +KA +Q++L P +
Sbjct: 1314 VWSGEYSFEKE--EELVELLARHCYVQL--------GASAESKA---VQELLPSCIPHKL 1360
Query: 1181 RHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARK--WPFFGAKLFAAQPAQLS 1238
P ++ L K Q P +R + A + WP ++LF
Sbjct: 1361 YRTKPPDRWASLVTAACAKAPYTQKQVTPLAVREQVVDAARLQWPLLFSRLFEVITLSGP 1420
Query: 1239 SKENALVWIAVNEDGVSILD-HNTMQVHITYP 1269
+ +AVN G+ LD M + +++P
Sbjct: 1421 RLPKTQLILAVNWKGLCFLDQQEKMLLELSFP 1452
Score = 69.7 bits (169), Expect = 2e-11
Identities = 83/417 (19%), Positives = 167/417 (40%), Gaps = 38/417 (9%)
Query: 877 VSLAQTALQVCLVHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFL 936
+ L + L HP LQ E+YCQ++KQ + ++S + WQLL LC LF P L
Sbjct: 1690 LELTDQIFTLALQHPALQDEVYCQILKQLT-HNSNRHSEERGWQLLWLCTGLFPPSKGLL 1748
Query: 937 WYVKQQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLP 996
Q+ D R A C R +++ LRTG R+ P ++EV + +
Sbjct: 1749 ----PHAQKFIDTR-RGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEA-----AEQNVSR 1798
Query: 997 FSIPVHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKPSHSGFALF---TDDPSGRDLE 1053
++F N T ++ ++ V + + + + S G +LF +D +
Sbjct: 1799 ICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQL--ASWEGCSLFIKISDKVISQKEG 1856
Query: 1054 HCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLL 1113
S++ +S W + K G T ++ + +L+ + + + +L
Sbjct: 1857 DFFFDSLR---EVSDWVKKNKPQKEGAPV--TLPYQVYFMRKLWLNISPGKDVNADTILH 1911
Query: 1114 ASQTSREIVAGRFPINKELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLD 1173
Q + + G ++E A+ +A L+ + ++ + P ++L
Sbjct: 1912 YHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLASVP-------------KILR 1958
Query: 1174 RFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQ 1233
P +E+ + + + + + E +L +WP FG+ F +
Sbjct: 1959 ELVPENLTRLMSSEEWK---KSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVK 2015
Query: 1234 PAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSI 1290
S + ++ IA+N GV ++ T + TYP++ ++++ F + + S+
Sbjct: 2016 QTSEPSYPDVIL-IAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSL 2071
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 61.2 bits (147), Expect = 6e-09
Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 12/128 (9%)
Query: 561 LQRTSSY-STDGLGLG-GESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIR 618
L+R+ SY T G G L KSGY +K G+ K+WKRR+F L I Y+K D R
Sbjct: 179 LRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--R 236
Query: 619 KPQGQVDLNS-----RCQIVRGE---GSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSL 670
+P + L C + G+ F++I+ +T+Y+ ADSP + WI+ + +
Sbjct: 237 EPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAA 296
Query: 671 LKVQATGP 678
++ P
Sbjct: 297 VQALKCHP 304
>gi|118402590 myosin XV [Homo sapiens]
Length = 3530
Score = 59.3 bits (142), Expect = 2e-08
Identities = 94/460 (20%), Positives = 191/460 (41%), Gaps = 60/460 (13%)
Query: 829 MLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFI-NVPVEAASVDYHVSLAQTALQVC 887
MLC++K L SL L +L A +F + F+ + P++ S + + L++C
Sbjct: 3047 MLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQS---DLDVLCNLLKLC 3103
Query: 888 LVHPELQSEIYCQLMKQTSCRPPQKY-SLMQCWQLLAL------CAPLFLPQHHFLWYVK 940
H ++ E YCQ++KQ + K S + W+LL + C+ + H L
Sbjct: 3104 GDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVL---HPHLTRFL 3160
Query: 941 QQLQRHADPRSETGQYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIP 1000
Q + R P A C++ +++TLR G R PS +E+ ++L L F +P
Sbjct: 3161 QDVSR--TPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQL-FLLP 3217
Query: 1001 VHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRKP-SHSGFALFTDDPSGRDLEHC-LQG 1058
G + + + ++ + E+ + +P + + + +F G+ + C L
Sbjct: 3218 ----GGLERHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHV--CPLSR 3271
Query: 1059 SVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTS 1118
I D S+ EQ +GG +++ R+ + +K E + + +Q
Sbjct: 3272 RAYILDVASEMEQV---------DGG----YMLWFRRVLWDQPLKFENELYVTMHYNQVL 3318
Query: 1119 REIVAGRF---PINK--ELALEMAALMAQVEYGDLEKPALPGPGGTSPAKAQHLLQQVLD 1173
+ + G F P ++ E L+ + +A +++ + LP +++V +
Sbjct: 3319 PDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDHFYLPS------------VREVQE 3366
Query: 1174 RFHPRRYRHGAPAEQLRHLADMLTTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQ 1233
+ YR A + L ++++ Q SP + +L + P FG+ F Q
Sbjct: 3367 YIPAQLYRTTAGSTWL----NLVSQHRQQTQALSPHQARAQFLGLLSALPMFGSSFFFIQ 3422
Query: 1234 PAQLSSKENALVWIAVNEDGVSILDHNTMQVHITYPYSSV 1273
+ + +A+N +G++ L T ++ + +P +
Sbjct: 3423 SCSNIAVPAPCI-LAINHNGLNFLSTETHELMVKFPLKEI 3461
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 59.3 bits (142), Expect = 2e-08
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 7/92 (7%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQ- 639
K GYL K G VKTWK RWF L + ++ Y+K + +P +DL + C V+ + SQ
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFK--DQMSPEPIRILDL-TECSAVQFDYSQE 223
Query: 640 ---TFQLISEKKTYYLTADSPSLLEEWIRVLQ 668
F L+ +T+YL A + +EWI++L+
Sbjct: 224 RVNCFCLVFPFRTFYLCAKTGVEADEWIKILR 255
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 57.4 bits (137), Expect = 9e-08
Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 8/100 (8%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGS-- 638
K+GY +K G+ +K WKRR+F L + I Y+K S++ ++P + L ++ + S
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFK--SELEKEPLRVIPLKEVHKVQECKQSDI 251
Query: 639 ----QTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQ 674
F++++ +T+Y+ ADSP + WI+ + + Q
Sbjct: 252 MMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 57.4 bits (137), Expect = 9e-08
Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 8/100 (8%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGS-- 638
K+GY +K G+ +K WKRR+F L + I Y+K S++ ++P + L ++ + S
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFK--SELEKEPLRVIPLKEVHKVQECKQSDI 251
Query: 639 ----QTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQ 674
F++++ +T+Y+ ADSP + WI+ + + Q
Sbjct: 252 MMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ 291
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 54.3 bits (129), Expect = 8e-07
Identities = 36/107 (33%), Positives = 58/107 (54%), Gaps = 6/107 (5%)
Query: 571 GLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRC 630
G G GG + G+L K + +K ++RRWFVL G + YY+S +++ +G ++L +
Sbjct: 81 GSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATAN 140
Query: 631 QIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLLKVQA 675
V E S F +IS +TY+L A S + W+ L+ L K +A
Sbjct: 141 ITV--EDSCNF-IISNGGAQTYHLKASSEVERQRWVTALE-LAKAKA 183
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 54.3 bits (129), Expect = 8e-07
Identities = 42/136 (30%), Positives = 64/136 (47%), Gaps = 24/136 (17%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQT 640
K+G+L K S +K W++RWFVLR Q+ YYK ++ KPQG + L +G+Q
Sbjct: 40 KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEI--KPQGFISL---------QGTQV 88
Query: 641 FQLI--SEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVK 698
+L E +L SP E KV A LL ++ ++ W+ ++
Sbjct: 89 TELPPGPEDPGKHLFEISPGGAGE-------REKVPANPEALLLMASSQRDMEDWVQAIR 141
Query: 699 HGHSKVVWCALVGKIF 714
+V+W L G IF
Sbjct: 142 ----RVIWAPLGGGIF 153
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 53.9 bits (128), Expect = 1e-06
Identities = 30/103 (29%), Positives = 52/103 (50%), Gaps = 6/103 (5%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRC---QIVRGEG 637
K GY++K G + K W RWFVL+ I YY S+ ++ +G + L+ C + +G
Sbjct: 213 KQGYMMKKGHRRKNWTERWFVLKPNIISYY--VSEDLKDKKGDILLDENCCVESLPDKDG 270
Query: 638 SQTFQLIS-EKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPP 679
+ L+ KT+ ++A +EWI+ + S + + G P
Sbjct: 271 KKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSP 313
Score = 35.8 bits (81), Expect = 0.29
Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 21/179 (11%)
Query: 3 ELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELE---QRLLEAE----- 54
E K V+ Q R T+L R +L ++ E +A K ELE QR+ E E
Sbjct: 372 EEKKRLQTQVELQAR---FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
Query: 55 -QRAENAETQVGVMEEKVKLSNLKNVDSEGS----LHRKYQELLKAIKGKDELISQLEAQ 109
Q A E Q EE V+ + ++ E S L + + E +AI+ + +LE Q
Sbjct: 429 LQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQ 488
Query: 110 LEKQKQMRAEEAKTVQ----EKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQ 164
++Q E + ++ E+ ++++ +K KLEM KS ++ G ++
Sbjct: 489 RVLKEQALQEAMEQLEQLELERKQALEQYEEVK-KKLEMATNKTKSWKDKVAHHEGLIR 546
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 53.9 bits (128), Expect = 1e-06
Identities = 37/121 (30%), Positives = 57/121 (47%), Gaps = 15/121 (12%)
Query: 553 DYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQV-KTWKRRWFVLRQGQIMYYK 611
D+S + KL+ Y+ D + GYL K S KTW RRWF ++ Q++Y K
Sbjct: 249 DFSSDDSKLE----YNVDA----ANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK 300
Query: 612 SPSDVIRKPQGQVDLNSRCQIVRGEGSQ---TFQLISEKKTYYLTADSPSLLEEWIRVLQ 668
D P V+ C + E + F+++S K+ L ADS L + WI+ +Q
Sbjct: 301 KFKD---NPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQ 357
Query: 669 S 669
+
Sbjct: 358 T 358
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 53.5 bits (127), Expect = 1e-06
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%)
Query: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622
+ G + SG+L K + K WKRRWFVLR G++ YYK +D +KP
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58
Query: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667
+DLN Q+ G E S F + + + +YL ADS + +W+R +
Sbjct: 59 IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 53.5 bits (127), Expect = 1e-06
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%)
Query: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622
+ G + SG+L K + K WKRRWFVLR G++ YYK +D +KP
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58
Query: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667
+DLN Q+ G E S F + + + +YL ADS + +W+R +
Sbjct: 59 IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 53.5 bits (127), Expect = 1e-06
Identities = 35/108 (32%), Positives = 50/108 (46%), Gaps = 12/108 (11%)
Query: 574 LGGESLEKS-----------GYLLKMGSQV-KTWKRRWFVLRQGQIMYYKSPSDVIRKPQ 621
LGGE E S G+L K S KTW RRWF ++ Q++Y K D +
Sbjct: 250 LGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVV 309
Query: 622 GQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQS 669
+ L + E F+++S K+ L ADS LL+ W+ +QS
Sbjct: 310 DDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQS 357
>gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]
Length = 2186
Score = 53.5 bits (127), Expect = 1e-06
Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 16/146 (10%)
Query: 549 SLDSDYSEPEHKLQRTS-SYSTDGLGLGGESLEKSGYLLKMGSQ--------VKTWKRRW 599
S + D+ + + TS S S G G GG + KSG+L K V+++K+R+
Sbjct: 151 SFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRY 210
Query: 600 FVLRQ----GQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQ--TFQLISEKKTYY-L 652
F L Q IM + + ++P+G + L+S +V+ + F+L TY+ L
Sbjct: 211 FQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVL 270
Query: 653 TADSPSLLEEWIRVLQSLLKVQATGP 678
A++ S ++EWI L +L++ GP
Sbjct: 271 AAETESDMDEWIHTLNRILQISPEGP 296
>gi|194294543 alpha 3 type IV collagen binding protein isoform 3
[Homo sapiens]
Length = 752
Score = 52.4 bits (124), Expect = 3e-06
Identities = 42/182 (23%), Positives = 71/182 (39%), Gaps = 4/182 (2%)
Query: 502 QASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSEGDYAIPPDACSLDSDYSEPEHKL 561
+ S + +P + R SP RG+ SS ++EG A L S +++
Sbjct: 79 RTSSLLLLPPTPERALFASPSPDPSPRGLGASSGAAEGAGA----GLLLGCRASMSDNQS 134
Query: 562 QRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQ 621
+S D G +E+ G L K + + W+ RW VL+ + YYKS + +
Sbjct: 135 WNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCR 194
Query: 622 GQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPAL 681
G + L+ F + +YL A P ++WI ++ G +
Sbjct: 195 GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESS 254
Query: 682 LR 683
LR
Sbjct: 255 LR 256
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 52.4 bits (124), Expect = 3e-06
Identities = 29/116 (25%), Positives = 60/116 (51%), Gaps = 26/116 (22%)
Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDL------------- 626
++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L
Sbjct: 262 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDSKK 319
Query: 627 ---------NSRCQIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLL 671
+++ Q+++ ++ + E Y ++A +P EEWI+ +++ +
Sbjct: 320 PNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 375
Score = 35.0 bits (79), Expect = 0.49
Identities = 29/96 (30%), Positives = 39/96 (40%), Gaps = 9/96 (9%)
Query: 655 DSPSLLEEWIRVLQSLLKVQATGPPA-----LLRGGTKPTVKGWLTKVKHGHSKVV---W 706
D L EE +R L +K + P L P +GWL K+ G K W
Sbjct: 223 DGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLG-GRVKTWKRRW 281
Query: 707 CALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVDRS 742
L YY+ DK P G +P+ + I EV+ S
Sbjct: 282 FILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS 317
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/147 (23%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 13 DWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVK 72
+W+++ ++ Q + R Q KIRE +KM+ E+ + E E++ E + EEK++
Sbjct: 311 EWEEK---IQEQEEKIREQEEKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 73 LSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIK 132
+ E + R+ + + + K+E I +LE ++ +Q+++R +E K +E+ + +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 422
Query: 133 EWVTLKLAKLEMENQHLKSHNQRLVEQ 159
E + AK+ + + ++ +++ EQ
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQ 449
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/145 (18%), Positives = 74/145 (51%), Gaps = 9/145 (6%)
Query: 27 RFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLH 86
+ R Q K R+ +KM + E+++ E E++ + E ++ EEK++ + E +
Sbjct: 592 KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 87 RKYQELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMEN 146
+ +++ + ++E + + E + +Q++ E+ K ++E+ KI+E + ++ +
Sbjct: 651 EQEEKMCE----QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM----MQEQE 702
Query: 147 QHLKSHNQRLVEQVGSLQDALEAIQ 171
+ + +++ EQ +Q+ E ++
Sbjct: 703 EKMWEQEEKMCEQEEKMQEQEEKMR 727
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/122 (19%), Positives = 64/122 (52%), Gaps = 9/122 (7%)
Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ---ELLKAIK 97
+K+QE E+++ E E++ E ++ EEK++ + E + R+ + E + ++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 98 GKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLV 157
++E++ + E ++ +Q++M E+ + ++E K+ E ++ E + + +++
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR------EQEEKRQEEEKIR 420
Query: 158 EQ 159
EQ
Sbjct: 421 EQ 422
Score = 40.8 bits (94), Expect = 0.009
Identities = 30/139 (21%), Positives = 67/139 (48%), Gaps = 6/139 (4%)
Query: 36 RELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSL---HRKYQEL 92
R+ DKM E+++ E E++ E ++ EEK + K E + K QE
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
Query: 93 LKAIKGKDELISQLEAQLEKQKQMRAEEAKTV---QEKAAKIKEWVTLKLAKLEMENQHL 149
+ I+ ++E I + E ++Q++ E+ + + +EK + +E + + K+ + + +
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 150 KSHNQRLVEQVGSLQDALE 168
+ +++ EQ +Q+ E
Sbjct: 685 REQEEKIREQEEMMQEQEE 703
Score = 36.6 bits (83), Expect = 0.17
Identities = 24/105 (22%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 33 SKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQEL 92
+++ + +KM E+++ E E++ + E ++ EEK++ K E + K +++
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 93 LK----AIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133
+ + ++++ Q E EK+++MR +E + + EK KI+E
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRE 395
Score = 33.9 bits (76), Expect = 1.1
Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 2/138 (1%)
Query: 34 KIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELL 93
KIREL +KM E E+ + E+R E + + ++ + + + K +E
Sbjct: 392 KIREL-EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 94 KAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHN 153
K + ++E I + E E++K+ EE +EK + +E + + K+ + + ++
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE-QEEIWRQKEKMHEQEEKIRKQE 509
Query: 154 QRLVEQVGSLQDALEAIQ 171
+++ Q +++ E I+
Sbjct: 510 EKVWRQEEKIREQEEKIR 527
Score = 33.9 bits (76), Expect = 1.1
Identities = 17/93 (18%), Positives = 49/93 (52%), Gaps = 4/93 (4%)
Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKD 100
+KMQE E+ + E++ E ++ EEK++ + E + + +++ + ++
Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE----QE 716
Query: 101 ELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133
E + + E ++ +Q++ E+ ++++ K++E
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 32.7 bits (73), Expect = 2.4
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 19/120 (15%)
Query: 29 RLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKV-----KLSNLKNVDSEG 83
R + KIRE +K QE E ++ E++ E ++ E+K+ K+ + + E
Sbjct: 413 RQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 470
Query: 84 SLHRKYQELL----KAIKGKDELISQLEAQLEKQKQMRAEEAKT------VQEKAAKIKE 133
R+ QE + + I ++E+ Q E E+++++R +E K ++E+ KI+E
Sbjct: 471 K--RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Score = 32.7 bits (73), Expect = 2.4
Identities = 18/87 (20%), Positives = 47/87 (54%), Gaps = 3/87 (3%)
Query: 41 DKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKD 100
+KM E E+++ E E+ E ++ E+K++ K + E + + +++ + ++
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ---EE 710
Query: 101 ELISQLEAQLEKQKQMRAEEAKTVQEK 127
++ Q E E++++MR +E K +++
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Score = 32.0 bits (71), Expect = 4.2
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 19/131 (14%)
Query: 19 LTLETQLFRFRLQASKIR-ELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLK 77
LT E L + I E L +K +L+++L E +E +E Q+ V E K KL K
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE--SEKSEIQLNVKELKRKLERAK 255
Query: 78 NVDSEGSLHRKYQELLKAIKG----------KDELISQLEAQLEKQKQMRAEEA-----K 122
+ + L + L K ++ ++EL ++L Q E +K R EE +
Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE-EKMWRQEEKIQEWEE 314
Query: 123 TVQEKAAKIKE 133
+QE+ KI+E
Sbjct: 315 KIQEQEEKIRE 325
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 52.0 bits (123), Expect = 4e-06
Identities = 30/118 (25%), Positives = 60/118 (50%), Gaps = 26/118 (22%)
Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDL------------- 626
++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L
Sbjct: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVDDPRK 318
Query: 627 ---------NSRCQIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLLKV 673
N++ Q+++ ++ + E Y ++A + +EWI+ +Q+ + V
Sbjct: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 376
Score = 38.5 bits (88), Expect = 0.044
Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 14/133 (10%)
Query: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD--RS 742
P +GWL K+ G K W L YY+ DK P G +P+ + I EVD R
Sbjct: 260 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRK 318
Query: 743 CDSDEDYEAGGTRRLLSSHCTLV---IHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSS 799
+ E Y +L+ + T + H + T+ EKD W+ + A
Sbjct: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAA----- 373
Query: 800 AKVGTAYEQLIGK 812
V YE L +
Sbjct: 374 VSVDPFYEMLAAR 386
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 51.2 bits (121), Expect = 7e-06
Identities = 45/184 (24%), Positives = 88/184 (47%), Gaps = 19/184 (10%)
Query: 17 RCLTLETQLFRFRLQASKIRELLADKMQ-------ELEQRLLEAEQRAENAETQVGVMEE 69
R + LE + + ++ + E+L + Q EL Q+L ++ E + +V EE
Sbjct: 1526 RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE 1585
Query: 70 KVKLSNLKNVDSEGSLHRKYQELLK---AIKGKDELISQLEAQLEKQKQMR-AEEAKTVQ 125
K+ + + L K +EL ++K K+E + LE +LE + + AE + +
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE 1645
Query: 126 EKAAKIKEWVTLKLAKLEME-----NQHLKSHNQRLVE---QVGSLQDALEAIQIAPSRK 177
+K A IK+ + ++ + E + HL N +L E +V L++ L++++ + S
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSET 1705
Query: 178 LLVP 181
L+VP
Sbjct: 1706 LIVP 1709
Score = 39.3 bits (90), Expect = 0.026
Identities = 38/172 (22%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Query: 15 QKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLS 74
Q++ L LET+ Q +++ D EL+ ++ + + E Q ME+KVK S
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK-S 883
Query: 75 NLKNVDSEGSLHRKYQELLKAI-KGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKE 133
+ +S+ K QE K I K+ +I Q+ +K+ ++ ++ ++ + E
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 134 WVTLKLAKLEMENQHLKSH--------NQRLVEQVGSLQDALEAIQIAPSRK 177
K E + + +K ++L++Q L+ LE + S+K
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995
Score = 35.8 bits (81), Expect = 0.29
Identities = 39/193 (20%), Positives = 90/193 (46%), Gaps = 24/193 (12%)
Query: 14 WQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQ---RAENAETQVGVMEE- 69
W ++ L+ Q ++ + K+RE K ++ ++ LL+ ++ +A E +E+
Sbjct: 627 WTEKLQVLKQQ---YQTEMEKLRE----KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
Query: 70 KVKLSNLKNVDSEGS----LHRKYQELLKAIKGK-DELISQLEAQLEKQKQMRAEEAK-- 122
VK + L+++ SE S K +E L +K + D++ +LEA++++QK ++
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 123 ------TVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSR 176
++Q +K+ + L+ ++HLK H + ++ + +Q A ++
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 177 KLLVPPYGAAEQD 189
+ Y +A +
Sbjct: 800 LDVFQSYQSATHE 812
Score = 32.0 bits (71), Expect = 4.2
Identities = 45/161 (27%), Positives = 74/161 (45%), Gaps = 24/161 (14%)
Query: 20 TLETQLFRFRLQ-ASKIREL------LADKMQELEQRLLEAEQRAENAETQVGVMEEKVK 72
TL+ + F Q A K +EL +K QE+E LLE+ Q ET + + K
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE----ETNQLLKKIAEK 2048
Query: 73 LSNLKNVDSEGSLHRKYQELLKAIKGK-----DELISQLEAQLEKQKQMRAEEAKTVQEK 127
+LK ++Y+E+L A + + +L +QLE +L+K+ Q + E+ +
Sbjct: 2049 DDDLKRT------AKRYEEILDAREEEMTAKVRDLQTQLE-ELQKKYQQKLEQEENPGND 2101
Query: 128 AAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALE 168
I E T +LA+ K Q EQ+ +L+D L+
Sbjct: 2102 NVTIMELQT-QLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 51.2 bits (121), Expect = 7e-06
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 583 GYLLKMGSQV-KTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTF 641
GYL K S KTW RRWF ++ Q++Y K D + + L S E F
Sbjct: 273 GYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCF 332
Query: 642 QLISEKKTYYLTADSPSLLEEWIRVLQS 669
+++S K+ L ADS L + W++ +Q+
Sbjct: 333 EVLSPTKSCMLQADSEKLRQAWVQAVQA 360
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 51.2 bits (121), Expect = 7e-06
Identities = 29/114 (25%), Positives = 58/114 (50%), Gaps = 26/114 (22%)
Query: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNS----------- 628
++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L +
Sbjct: 266 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDPRK 323
Query: 629 -----------RCQIVRGEGSQTFQLISEKK--TYYLTADSPSLLEEWIRVLQS 669
+ Q+++ ++ + E Y ++A SP EEW++ +++
Sbjct: 324 PNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKA 377
Score = 33.5 bits (75), Expect = 1.4
Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 4/56 (7%)
Query: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD 740
P +GWL K+ G K W L YY+ DK P G +P+ + I EV+
Sbjct: 265 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE 319
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 51.2 bits (121), Expect = 7e-06
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 17/102 (16%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQI------VR 634
K G+L K S VK W++R+FVLR Q+ YYK D KPQG + L C I
Sbjct: 49 KMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDT--KPQGCMYLPG-CTIKEIATNPE 105
Query: 635 GEGSQTFQLISE--------KKTYYLTADSPSLLEEWIRVLQ 668
G F++I + +Y L A S + +EEW++ L+
Sbjct: 106 EAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 147
Score = 33.1 bits (74), Expect = 1.9
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 6/57 (10%)
Query: 687 KPTVKGWLTK----VKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEV 739
+P GWL K VK+ + + L + YYY+ ED +P GC+ + I+E+
Sbjct: 46 RPIKMGWLKKQRSIVKNWQQR--YFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 100
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 51.2 bits (121), Expect = 7e-06
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 17/102 (16%)
Query: 581 KSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQI------VR 634
K G+L K S VK W++R+FVLR Q+ YYK D KPQG + L C I
Sbjct: 42 KMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDT--KPQGCMYLPG-CTIKEIATNPE 98
Query: 635 GEGSQTFQLISE--------KKTYYLTADSPSLLEEWIRVLQ 668
G F++I + +Y L A S + +EEW++ L+
Sbjct: 99 EAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 140
Score = 33.1 bits (74), Expect = 1.9
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 6/57 (10%)
Query: 687 KPTVKGWLTK----VKHGHSKVVWCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEV 739
+P GWL K VK+ + + L + YYY+ ED +P GC+ + I+E+
Sbjct: 39 RPIKMGWLKKQRSIVKNWQQR--YFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 93
>gi|58331179 KIAA1688 protein [Homo sapiens]
Length = 1114
Score = 50.8 bits (120), Expect = 9e-06
Identities = 37/125 (29%), Positives = 65/125 (52%), Gaps = 4/125 (3%)
Query: 829 MLCYSKDGLYASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCL 888
ML +S + + + ++ EA +LFK Q+++ A + HV+L + A +
Sbjct: 719 MLAWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMG-DRRAKADPLHVAL-EVATKGWS 776
Query: 889 VHPELQSEIYCQLMKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHAD 948
V L+ E+Y QL +QT+ + SL + W+L+A+C F P F Y++ + RH D
Sbjct: 777 VQG-LRDELYIQLCRQTT-ENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMD 834
Query: 949 PRSET 953
P ++T
Sbjct: 835 PVNDT 839
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,064,745
Number of Sequences: 37866
Number of extensions: 2880509
Number of successful extensions: 15039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 150
Number of HSP's successfully gapped in prelim test: 724
Number of HSP's that attempted gapping in prelim test: 12087
Number of HSP's gapped (non-prelim): 3043
length of query: 1364
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1249
effective length of database: 13,892,928
effective search space: 17352267072
effective search space used: 17352267072
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.