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Search of human proteins with 54792740
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54792740 transmembrane and coiled-coil domain family 2 [Homo
sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54792740 transmembrane and coiled-coil domain family 2 [Homo ... 1391 0.0
gi|190014610 transmembrane and coiled-coil domain family 1 isofo... 630 e-180
gi|190014612 transmembrane and coiled-coil domain family 1 isofo... 588 e-168
gi|188497714 transmembrane and coiled-coil domain family 3 [Homo... 474 e-133
gi|39930343 transmembrane and coiled-coil domain family 1 isofor... 391 e-108
gi|4503177 testis expressed 28 [Homo sapiens] 112 9e-25
gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens] 47 6e-05
gi|21735548 centrosomal protein 2 [Homo sapiens] 47 8e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 46 1e-04
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 46 1e-04
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 46 1e-04
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 46 1e-04
gi|46852390 coiled-coil domain containing 6 [Homo sapiens] 44 4e-04
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 44 5e-04
gi|50409756 SRp25 nuclear protein isoform 1 [Homo sapiens] 44 7e-04
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 43 9e-04
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 43 9e-04
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 42 0.002
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 42 0.002
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 42 0.002
gi|187761324 shootin1 isoform a [Homo sapiens] 42 0.002
gi|50511340 shootin1 isoform b [Homo sapiens] 42 0.002
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 42 0.002
gi|239756545 PREDICTED: hypothetical protein XP_002344931 [Homo ... 42 0.003
gi|239751065 PREDICTED: hypothetical protein XP_002347692 [Homo ... 42 0.003
gi|239745511 PREDICTED: hypothetical protein XP_002343508 [Homo ... 42 0.003
gi|44890059 involucrin [Homo sapiens] 42 0.003
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 42 0.003
gi|31982906 cingulin-like 1 [Homo sapiens] 42 0.003
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 41 0.003
>gi|54792740 transmembrane and coiled-coil domain family 2 [Homo
sapiens]
Length = 709
Score = 1391 bits (3601), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPG 60
MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPG
Sbjct: 1 MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPG 60
Query: 61 PRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSP 120
PRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSP
Sbjct: 61 PRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSP 120
Query: 121 DEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSS 180
DEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSS
Sbjct: 121 DEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSS 180
Query: 181 RRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLA 240
RRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLA
Sbjct: 181 RRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLA 240
Query: 241 EEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKIT 300
EEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKIT
Sbjct: 241 EEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKIT 300
Query: 301 EQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR 360
EQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR
Sbjct: 301 EQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR 360
Query: 361 LKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA 420
LKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA
Sbjct: 361 LKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA 420
Query: 421 VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECS 480
VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECS
Sbjct: 421 VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECS 480
Query: 481 SASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDL 540
SASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDL
Sbjct: 481 SASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDL 540
Query: 541 KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYE 600
KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYE
Sbjct: 541 KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYE 600
Query: 601 RARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVF 660
RARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVF
Sbjct: 601 RARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVF 660
Query: 661 VSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS 709
VSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS
Sbjct: 661 VSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS 709
>gi|190014610 transmembrane and coiled-coil domain family 1 isoform
a [Homo sapiens]
Length = 653
Score = 630 bits (1625), Expect = e-180
Identities = 365/672 (54%), Positives = 444/672 (66%), Gaps = 63/672 (9%)
Query: 57 PNPGPRSKPPDLKKIQQ------------LSEGSMFGHGLKHLF-HSRRRSREREHQTSQ 103
P+PG +S+ + +K + L ++ G GLKHLF H RRRS H Q
Sbjct: 13 PDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQ 72
Query: 104 DSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKR 163
+ + + ++ E + +P PTA NRVLQQIR P +KR
Sbjct: 73 IQADPEPEMDLESQNACAE---------------IDGVPTHPTALNRVLQQIRVPPKMKR 117
Query: 164 GASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSST 223
G SLHS G E +GSP + RK+ Q+ + A++ RPRSSST
Sbjct: 118 GTSLHSRRG--------------KPEAPKGSPQINRKSGQE--MTAVMQSG--RPRSSST 159
Query: 224 TDTALLLADGSNVYLLAEEA-------EGIGDKVDKGDLVALSLPAGH--GDTDGPISLD 274
TD A A A EG +++++ ++ +L+ + TDG I D
Sbjct: 160 TDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTD 219
Query: 275 VPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQ 334
DG PDPQRTKAAI HL QKILK+TEQIKI Q ARDDNVAEYLKLAN+ADKQQ +RIKQ
Sbjct: 220 SVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQ 279
Query: 335 VFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAG 394
VFEKKNQKSAQTI QL KKLEHY R+L+E+EQNG RQPKDV RDM QGLKDVGA V
Sbjct: 280 VFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKV--- 336
Query: 395 ISGFGGGVVEGVKGSLSGLSQATHTA---VVSKPREFASLIRNKFGSADNIAHLKDPLED 451
+GF GVV+ VKG S SQATH+A VVSKPRE ASLIRNKFGSADNI +LKD LE+
Sbjct: 337 -TGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEE 395
Query: 452 GPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYG 511
G ++A +AL + SSPKYGS+++CSSA++ S GA S +G GA S K+N L
Sbjct: 396 GQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA-SSSKTNTLDM 454
Query: 512 APGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLND 571
DALL E++EI+E Q+ LE+S E LK QRDY+ + Q LQEERYR ERLEEQLND
Sbjct: 455 QSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLND 514
Query: 572 LTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQL 631
LTELHQNE+ NLKQELASMEEK+AYQSYERARDIQEA+E+C TR++K+ELQQQQQQVVQL
Sbjct: 515 LTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQL 574
Query: 632 EGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLL 691
EG+ENA AR LLGK IN++LA+MAVLLVFVST+AN + PLMKTR R ST LV+ + L
Sbjct: 575 EGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFL 634
Query: 692 WKHWDSLTYLLE 703
WKHWD+L +E
Sbjct: 635 WKHWDALFSYVE 646
>gi|190014612 transmembrane and coiled-coil domain family 1 isoform
c [Homo sapiens]
Length = 539
Score = 588 bits (1515), Expect = e-168
Identities = 331/555 (59%), Positives = 395/555 (71%), Gaps = 35/555 (6%)
Query: 161 IKRGASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRS 220
+KRG SLHS G E +GSP + RK+ Q+ + A++ RPRS
Sbjct: 1 MKRGTSLHSRRG--------------KPEAPKGSPQINRKSGQE--MTAVMQSG--RPRS 42
Query: 221 SSTTDTALLLADGSNVYLLAEEA-------EGIGDKVDKGDLVALSLPAGH--GDTDGPI 271
SSTTD A A A EG +++++ ++ +L+ + TDG I
Sbjct: 43 SSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSI 102
Query: 272 SLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSR 331
D DG PDPQRTKAAI HL QKILK+TEQIKI Q ARDDNVAEYLKLAN+ADKQQ +R
Sbjct: 103 HTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAAR 162
Query: 332 IKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANV 391
IKQVFEKKNQKSAQTI QL KKLEHY R+L+E+EQNG RQPKDV RDM QGLKDVGA V
Sbjct: 163 IKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKV 222
Query: 392 RAGISGFGGGVVEGVKGSLSGLSQATHTA---VVSKPREFASLIRNKFGSADNIAHLKDP 448
+GF GVV+ VKG S SQATH+A VVSKPRE ASLIRNKFGSADNI +LKD
Sbjct: 223 ----TGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDS 278
Query: 449 LEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNA 508
LE+G ++A +AL + SSPKYGS+++CSSA++ S GA S +G GA S K+N
Sbjct: 279 LEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA-SSSKTNT 337
Query: 509 LYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQ 568
L DALL E++EI+E Q+ LE+S E LK QRDY+ + Q LQEERYR ERLEEQ
Sbjct: 338 LDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQ 397
Query: 569 LNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
LNDLTELHQNE+ NLKQELASMEEK+AYQSYERARDIQEA+E+C TR++K+ELQQQQQQV
Sbjct: 398 LNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQV 457
Query: 629 VQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVL 688
VQLEG+ENA AR LLGK IN++LA+MAVLLVFVST+AN + PLMKTR R ST LV+ +
Sbjct: 458 VQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFI 517
Query: 689 FLLWKHWDSLTYLLE 703
LWKHWD+L +E
Sbjct: 518 AFLWKHWDALFSYVE 532
>gi|188497714 transmembrane and coiled-coil domain family 3 [Homo
sapiens]
Length = 477
Score = 474 bits (1220), Expect = e-133
Identities = 257/466 (55%), Positives = 327/466 (70%), Gaps = 21/466 (4%)
Query: 249 KVDKGDLVALSLPAG--HGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIE 306
+V++ D+ LSLP G +D ++ DVPDG D + K D L QKILK+TEQIKIE
Sbjct: 26 RVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIE 85
Query: 307 QEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQ 366
Q +RD NVAEYLKL NNADKQQ RIKQVFEKKNQKSA +IAQL KKLE Y R+L+EIEQ
Sbjct: 86 QTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
Query: 367 NGPSRQPKDV----LRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVV 422
NG SR KD+ L+D+ + LKD R +E K + G+S V
Sbjct: 146 NGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPH-----CMESSKSGMPGVSLTPPVFVF 200
Query: 423 SKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSA 482
+K REFA+LIRNKFGSADNIAHLK+ LE+ PE +ARA GSAT+V+ PKYGSDDECSS
Sbjct: 201 NKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSG 260
Query: 483 SASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKT 542
++ SA + N G GGA + + G L +LEELREIK+ Q+ L + +E LK
Sbjct: 261 TSGSADSNGNQSFGAGGA-------STLDSQGKLAVILEELREIKDTQAQLAEDIEALKV 313
Query: 543 QLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERA 602
Q +R+Y +++Q LQEERYRYERLE+QL+DLT+LHQ+E NLKQELAS+EEKVAYQ+YER+
Sbjct: 314 QFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERS 373
Query: 603 RDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVS 662
RDIQEA+ESC TR++KLEL QQ+QQ +Q + V NA+ LLG+ INVILA M V+LV VS
Sbjct: 374 RDIQEALESCQTRISKLELHQQEQQALQTDTV---NAKVLLGRCINVILAFMTVILVCVS 430
Query: 663 TIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLP 708
TIA F++P+MK+R I T V +L + K+WD + +E +++P
Sbjct: 431 TIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIP 476
>gi|39930343 transmembrane and coiled-coil domain family 1 isoform b
[Homo sapiens]
Length = 329
Score = 391 bits (1004), Expect = e-108
Identities = 210/327 (64%), Positives = 250/327 (76%), Gaps = 8/327 (2%)
Query: 380 MQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA---VVSKPREFASLIRNKF 436
M QGLKDVGA V +GF GVV+ VKG S SQATH+A VVSKPRE ASLIRNKF
Sbjct: 1 MHQGLKDVGAKV----TGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKF 56
Query: 437 GSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAG 496
GSADNI +LKD LE+G ++A +AL + SSPKYGS+++CSSA++ S GA S +G
Sbjct: 57 GSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGI 116
Query: 497 PGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQ 556
GA S K+N L DALL E++EI+E Q+ LE+S E LK QRDY+ + Q LQ
Sbjct: 117 AVGA-SSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQ 175
Query: 557 EERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRV 616
EERYR ERLEEQLNDLTELHQNE+ NLKQELASMEEK+AYQSYERARDIQEA+E+C TR+
Sbjct: 176 EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRI 235
Query: 617 TKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRL 676
+K+ELQQQQQQVVQLEG+ENA AR LLGK IN++LA+MAVLLVFVST+AN + PLMKTR
Sbjct: 236 SKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRN 295
Query: 677 RITSTTLLVLVLFLLWKHWDSLTYLLE 703
R ST LV+ + LWKHWD+L +E
Sbjct: 296 RTFSTLFLVVFIAFLWKHWDALFSYVE 322
>gi|4503177 testis expressed 28 [Homo sapiens]
Length = 410
Score = 112 bits (281), Expect = 9e-25
Identities = 70/185 (37%), Positives = 107/185 (57%), Gaps = 5/185 (2%)
Query: 516 LDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
L + EL E K L++S LK + D + + LQEE+ R +EEQ+N +
Sbjct: 202 LQKVKAELEEAKRFHISLQESYHSLKERSLTDLQLLLESLQEEKCRQALMEEQVNGRLQG 261
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVE 635
NE+ NLK LA EE++AY SYERA++I E E+ +R++KLE+ QQV QLE E
Sbjct: 262 QLNEIYNLKHNLACSEERMAYLSYERAKEIWEITETFKSRISKLEM---LQQVTQLEAAE 318
Query: 636 NANAR--ALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWK 693
+ +R +L KF++ L+L VLLVFVST+ + L+ +RL + +L+ + L W+
Sbjct: 319 HLQSRPPQMLFKFLSPRLSLATVLLVFVSTLCACPSSLISSRLCTCTMLMLIGLGVLAWQ 378
Query: 694 HWDSL 698
W ++
Sbjct: 379 RWRAI 383
Score = 73.9 bits (180), Expect = 5e-13
Identities = 37/99 (37%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 268 DGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQ 327
DGP P D D + +IL ++EQ+++E+ +RD N YLKL + AD+
Sbjct: 30 DGPSG---PSSLADGGLAHNLQDSVRHRILYLSEQLRVEKASRDGNTVSYLKLVSKADRH 86
Query: 328 QVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQ 366
QV I+Q FEK NQ+++ TIAQ+ +L ++L+E+E+
Sbjct: 87 QVPHIQQAFEKVNQRASATIAQIEHRLHQCHQQLQELEE 125
>gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
Length = 728
Score = 47.0 bits (110), Expect = 6e-05
Identities = 64/239 (26%), Positives = 108/239 (45%), Gaps = 41/239 (17%)
Query: 420 AVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPE-----EAARALSGSATLVSSPKYG 474
A ++PR+ L + G+ + +A + P ED E E+ + S + +SSP +
Sbjct: 447 ATCTQPRK-RKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFT 505
Query: 475 SDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLE 534
S S+ S GA + A P A A AP L+A LE LR+ EG +
Sbjct: 506 SSS--SAKDLGSPGARALPSAVPDAA-------APADAPSGLEAELEHLRQALEGGLDTK 556
Query: 535 DSMED-----LKTQLQRDYTYMTQCLQEERYRYERLE-------EQLNDLTELHQNEMTN 582
++ E +K +++++ ++ LQ +R ++ LE E+L + TE + N
Sbjct: 557 EAKEKFLHEVVKMRVKQE-EKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKR----N 611
Query: 583 LKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARA 641
L++E+ + E + ++EA ES L K EL+Q +Q V +G E RA
Sbjct: 612 LRKEIERLRA-------ENEKKMKEANESRLR--LKRELEQARQARVCDKGCEAGRLRA 661
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 46.6 bits (109), Expect = 8e-05
Identities = 83/377 (22%), Positives = 147/377 (38%), Gaps = 48/377 (12%)
Query: 285 TKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQ--VSRIKQVFEKKNQK 342
T + Q+I+ + +Q+ QEAR+ + L + D+ Q +++ Q E Q+
Sbjct: 1769 TSLLLSQREQEIVVLQQQL---QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 343 SAQTIAQ----------LHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVR 392
Q Q L LE LKE ++G + K+ R +++ L G V+
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKE--RHGELQDHKEQARRLEEELAVEGRRVQ 1883
Query: 393 AGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSA----DNIAHLKDP 448
A +E V G L S+ A+++ ++ A + D+ +
Sbjct: 1884 A---------LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 449 LEDGPPE-EAARALSGSATLVSSPKYGSDDECSSA--SASSAGAGSNSGAGPGGALGSPK 505
L++ E EA RA S S+ + A A +A G L
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
Query: 506 SNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCL--QEERYRYE 563
+ +LDA R+++E E ++D + Q D + Q L ++E R++
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 564 RLEEQL--NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLEL 621
+ EQL L + Q M KQ L E+ E R + ++V R +L L
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREE------EEIRGLHQSV-----RELQLTL 2103
Query: 622 QQQQQQVVQLEGVENAN 638
Q++Q++++L + N
Sbjct: 2104 AQKEQEILELRETQQRN 2120
Score = 37.7 bits (86), Expect = 0.037
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 17/142 (11%)
Query: 519 LLEELREIKEGQSHLE-DSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQL-NDLTELH 576
L++E E +G S + S+E +K L RD +C QE + + L++QL L LH
Sbjct: 1705 LMQERAEEGKGPSKAQRGSLEHMKLIL-RDKEKEVECQQEHIHELQELKDQLEQQLQGLH 1763
Query: 577 -------------QNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLE-LQ 622
+ E+ L+Q+L E+ + + EA + R +LE LQ
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ 1823
Query: 623 QQQQQVVQLEGVENANARALLG 644
Q+QQQ E A AL G
Sbjct: 1824 QEQQQAQGQEERVKEKADALQG 1845
Score = 37.7 bits (86), Expect = 0.037
Identities = 35/143 (24%), Positives = 64/143 (44%), Gaps = 21/143 (14%)
Query: 521 EELREIKEGQSHLEDSMEDLK----------TQLQRDYTYMTQCLQEERYRYERLEEQLN 570
E + E++E + LE ++ L +Q +++ + Q LQE R + E E+ L
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 571 DLTELHQNEMTNLKQELASM--EEKVAYQSYERARDIQEAVESCLTRVTKL------ELQ 622
+ Q + QEL ++ E++ A ER ++ +A++ L + ELQ
Sbjct: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ 1862
Query: 623 QQQQQVVQLE---GVENANARAL 642
++Q +LE VE +AL
Sbjct: 1863 DHKEQARRLEEELAVEGRRVQAL 1885
Score = 32.3 bits (72), Expect = 1.6
Identities = 79/392 (20%), Positives = 162/392 (41%), Gaps = 58/392 (14%)
Query: 286 KAAIDHLHQKILKITEQIKIEQEARDD--NVAEYLKLANNADKQQVSRIKQVFEKKNQ-- 341
K D Q + + Q +EQE ++ EY ++ ++++ S + EK+ +
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 342 --KSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFG 399
+ A +I Q ++L R+ ++E + G ++ + ++Q +K+ A+ A +
Sbjct: 1070 VLQEADSIRQ--QELSALRQDMQEAQ--GEQKELSAQMELLRQEVKEKEADFLAQEAQ-- 1123
Query: 400 GGVVEGVKGSLSGLSQ--ATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEA 457
++E ++ S Q A+ A +K + +R+ + +A + P
Sbjct: 1124 --LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALA------AEQQPGNQ 1175
Query: 458 ARALSGSATLVSSPKYGSDDECSSASASSAGA--------------GSNSGAGPGGALGS 503
A+A + A+L S+ + C S S G G+ S G L +
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA 1235
Query: 504 PKSNALYGAPGNL-----------DALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMT 552
+ A+ A L D L +++++++E + E + T+LQ ++
Sbjct: 1236 LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 553 QCLQEERYRYERLEEQL-NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVES 611
Q QEE+ ++E + L ++L ELH+ M +L+ L E + + R++ +A +
Sbjct: 1296 QN-QEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAE--LQRMEAQGERELLQAAKE 1351
Query: 612 CLTRVTKLELQQQQQQVVQLEGVENANARALL 643
LT Q + Q +E A+A +L
Sbjct: 1352 NLT------AQVEHLQAAVVEARAQASAAGIL 1377
Score = 32.0 bits (71), Expect = 2.0
Identities = 30/120 (25%), Positives = 58/120 (48%), Gaps = 9/120 (7%)
Query: 515 NLDALLEELREIKEGQSHLEDSMEDLKTQL--QRDYTYMTQCLQEERYR----YERLEEQ 568
+L AL EE + + + L+ +EDLK+QL Q D + + +E+ R Y R++++
Sbjct: 990 DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKE 1049
Query: 569 LNDLTELHQNEMTNLKQELASMEEKVAYQSYERA---RDIQEAVESCLTRVTKLELQQQQ 625
L + +Q L ++E + + E + +D+QEA ++EL +Q+
Sbjct: 1050 LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Score = 30.0 bits (66), Expect = 7.7
Identities = 28/114 (24%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 520 LEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNE 579
LEE E Q L +E + + T++T L+E + Q++DL ++
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL----ESH 1617
Query: 580 MTNLKQELASMEEKVAYQS---YERARDIQEAVESCLTRVTKLELQQQQQQVVQ 630
T L +EL +++V Q E R + + R +L LQ+++ QV++
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 46.2 bits (108), Expect = 1e-04
Identities = 83/390 (21%), Positives = 161/390 (41%), Gaps = 56/390 (14%)
Query: 274 DVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIK 333
DV + +++K A++ +++ E+++ E +A +D L++ A K Q R
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDL 1580
Query: 334 QVFEKKNQKSAQTIAQLHKKLEHYRRRLK-EIEQNGPSRQPKDVLRDMQQGLKDVGANVR 392
Q +++N++ + QL ++L Y L+ E +Q + K + ++ LKD+
Sbjct: 1581 QARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAK---KKLEGDLKDLELQAD 1634
Query: 393 AGISGFGGGV--VEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLE 450
+ I G + + ++ + + A S+ FA+ N+ + A L E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 451 DGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALY 510
D E AR + +E + ASS NAL
Sbjct: 1695 DLAAAERARKQADL----------EKEELAEELASSLSG----------------RNALQ 1728
Query: 511 GAPGNLDALLEEL-REIKEGQSHLEDSMEDLK------TQLQRDYTYMTQCLQEERYRYE 563
L+A + +L E++E Q ++E + ++ QL + Q+ +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 564 RLEEQLNDL-TELHQNE---MTNLKQELASMEEKVAY---QSYERARDIQEAVESCLTRV 616
+LE Q +L ++LH+ E + K +A++E K+A Q + AR+ Q A +S +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 617 TK-----LELQQQQQQVVQL-EGVENANAR 640
K L+++ +++ Q E E NAR
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Score = 33.9 bits (76), Expect = 0.53
Identities = 58/310 (18%), Positives = 129/310 (41%), Gaps = 47/310 (15%)
Query: 306 EQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIE 365
+QE R E L D++ S QV E + QK AQ + +L ++LE ++R ++
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 366 QNGPSRQPKD--------VLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQAT 417
+N + + ++ VL +Q ++ + A + +G + L+
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKV 1282
Query: 418 HTAVVSKPREFASLIRNKFGSA----DNIAHLKDPLEDGPPEEAARALSGSATLVSSPKY 473
H + ++ ++ G A ++A L L+D +E + + VS+
Sbjct: 1283 HK-LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD--TQELLQEETRQKLNVSTKLR 1339
Query: 474 GSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELR-EIKEGQSH 532
++E +S + + A NL+ + L ++ + +
Sbjct: 1340 QLEEERNSLQ--------------------DQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 533 LED------SMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN---EMTNL 583
L+D ++E+ K + Q++ +TQ +E+ Y++LE+ N L + + ++ N
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 584 KQELASMEEK 593
+Q ++++E+K
Sbjct: 1440 RQLVSNLEKK 1449
Score = 32.7 bits (73), Expect = 1.2
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 28/135 (20%)
Query: 505 KSNALYGAPGNLDALLEE----LREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERY 560
K L A LD + + L++I+E + H+ D ED L ER
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED---------------LDSERA 1132
Query: 561 RYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE--AVESCL---TR 615
+ E+Q DL E E+ LK EL + A Q RA+ QE ++ L TR
Sbjct: 1133 ARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 616 VTKLELQQQQQQVVQ 630
+ ++Q+ +Q+ Q
Sbjct: 1189 SHEAQVQEMRQKHAQ 1203
Score = 32.0 bits (71), Expect = 2.0
Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 522 ELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRY----ERLEEQLNDLTELHQ 577
EL+E+++ S L + L+ QLQ + T + +E R R + LEE L+++ E
Sbjct: 874 ELKELEQKHSQLTEEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEM-EARL 931
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLE 632
E + Q+L + +K+A Q + ++E E + +LE + ++ +LE
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLE 984
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/142 (23%), Positives = 60/142 (42%), Gaps = 18/142 (12%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN 578
L ELR + + + +E + L+ Q+Q ++C ER R E LND QN
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQE---LQSKCSDGERARAE-----LNDKVHKLQN 1287
Query: 579 EMTNLKQELASMEEK----------VAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
E+ ++ L E K ++ Q + +QE L TKL ++++
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 629 VQLEGVENANARALLGKFINVI 650
+Q + E A+ L + I+ +
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTL 1369
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 46.2 bits (108), Expect = 1e-04
Identities = 83/390 (21%), Positives = 161/390 (41%), Gaps = 56/390 (14%)
Query: 274 DVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIK 333
DV + +++K A++ +++ E+++ E +A +D L++ A K Q R
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDL 1587
Query: 334 QVFEKKNQKSAQTIAQLHKKLEHYRRRLK-EIEQNGPSRQPKDVLRDMQQGLKDVGANVR 392
Q +++N++ + QL ++L Y L+ E +Q + K + ++ LKD+
Sbjct: 1588 QARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAK---KKLEGDLKDLELQAD 1641
Query: 393 AGISGFGGGV--VEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLE 450
+ I G + + ++ + + A S+ FA+ N+ + A L E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 451 DGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALY 510
D E AR + +E + ASS NAL
Sbjct: 1702 DLAAAERARKQADL----------EKEELAEELASSLSG----------------RNALQ 1735
Query: 511 GAPGNLDALLEEL-REIKEGQSHLEDSMEDLK------TQLQRDYTYMTQCLQEERYRYE 563
L+A + +L E++E Q ++E + ++ QL + Q+ +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 564 RLEEQLNDL-TELHQNE---MTNLKQELASMEEKVAY---QSYERARDIQEAVESCLTRV 616
+LE Q +L ++LH+ E + K +A++E K+A Q + AR+ Q A +S +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 617 TK-----LELQQQQQQVVQL-EGVENANAR 640
K L+++ +++ Q E E NAR
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Score = 33.9 bits (76), Expect = 0.53
Identities = 58/310 (18%), Positives = 129/310 (41%), Gaps = 47/310 (15%)
Query: 306 EQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIE 365
+QE R E L D++ S QV E + QK AQ + +L ++LE ++R ++
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 366 QNGPSRQPKD--------VLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQAT 417
+N + + ++ VL +Q ++ + A + +G + L+
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKV 1289
Query: 418 HTAVVSKPREFASLIRNKFGSA----DNIAHLKDPLEDGPPEEAARALSGSATLVSSPKY 473
H + ++ ++ G A ++A L L+D +E + + VS+
Sbjct: 1290 HK-LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD--TQELLQEETRQKLNVSTKLR 1346
Query: 474 GSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELR-EIKEGQSH 532
++E +S + + A NL+ + L ++ + +
Sbjct: 1347 QLEEERNSLQ--------------------DQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 533 LED------SMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN---EMTNL 583
L+D ++E+ K + Q++ +TQ +E+ Y++LE+ N L + + ++ N
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 584 KQELASMEEK 593
+Q ++++E+K
Sbjct: 1447 RQLVSNLEKK 1456
Score = 32.7 bits (73), Expect = 1.2
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 28/135 (20%)
Query: 505 KSNALYGAPGNLDALLEE----LREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERY 560
K L A LD + + L++I+E + H+ D ED L ER
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED---------------LDSERA 1139
Query: 561 RYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE--AVESCL---TR 615
+ E+Q DL E E+ LK EL + A Q RA+ QE ++ L TR
Sbjct: 1140 ARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 616 VTKLELQQQQQQVVQ 630
+ ++Q+ +Q+ Q
Sbjct: 1196 SHEAQVQEMRQKHAQ 1210
Score = 32.0 bits (71), Expect = 2.0
Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 522 ELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRY----ERLEEQLNDLTELHQ 577
EL+E+++ S L + L+ QLQ + T + +E R R + LEE L+++ E
Sbjct: 881 ELKELEQKHSQLTEEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEM-EARL 938
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLE 632
E + Q+L + +K+A Q + ++E E + +LE + ++ +LE
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLE 991
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/142 (23%), Positives = 60/142 (42%), Gaps = 18/142 (12%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN 578
L ELR + + + +E + L+ Q+Q ++C ER R E LND QN
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQE---LQSKCSDGERARAE-----LNDKVHKLQN 1294
Query: 579 EMTNLKQELASMEEK----------VAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
E+ ++ L E K ++ Q + +QE L TKL ++++
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 629 VQLEGVENANARALLGKFINVI 650
+Q + E A+ L + I+ +
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTL 1376
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 46.2 bits (108), Expect = 1e-04
Identities = 83/390 (21%), Positives = 161/390 (41%), Gaps = 56/390 (14%)
Query: 274 DVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIK 333
DV + +++K A++ +++ E+++ E +A +D L++ A K Q R
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDL 1587
Query: 334 QVFEKKNQKSAQTIAQLHKKLEHYRRRLK-EIEQNGPSRQPKDVLRDMQQGLKDVGANVR 392
Q +++N++ + QL ++L Y L+ E +Q + K + ++ LKD+
Sbjct: 1588 QARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAK---KKLEGDLKDLELQAD 1641
Query: 393 AGISGFGGGV--VEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLE 450
+ I G + + ++ + + A S+ FA+ N+ + A L E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 451 DGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALY 510
D E AR + +E + ASS NAL
Sbjct: 1702 DLAAAERARKQADL----------EKEELAEELASSLSG----------------RNALQ 1735
Query: 511 GAPGNLDALLEEL-REIKEGQSHLEDSMEDLK------TQLQRDYTYMTQCLQEERYRYE 563
L+A + +L E++E Q ++E + ++ QL + Q+ +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 564 RLEEQLNDL-TELHQNE---MTNLKQELASMEEKVAY---QSYERARDIQEAVESCLTRV 616
+LE Q +L ++LH+ E + K +A++E K+A Q + AR+ Q A +S +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 617 TK-----LELQQQQQQVVQL-EGVENANAR 640
K L+++ +++ Q E E NAR
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Score = 33.9 bits (76), Expect = 0.53
Identities = 58/310 (18%), Positives = 129/310 (41%), Gaps = 47/310 (15%)
Query: 306 EQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIE 365
+QE R E L D++ S QV E + QK AQ + +L ++LE ++R ++
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 366 QNGPSRQPKD--------VLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQAT 417
+N + + ++ VL +Q ++ + A + +G + L+
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKV 1289
Query: 418 HTAVVSKPREFASLIRNKFGSA----DNIAHLKDPLEDGPPEEAARALSGSATLVSSPKY 473
H + ++ ++ G A ++A L L+D +E + + VS+
Sbjct: 1290 HK-LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD--TQELLQEETRQKLNVSTKLR 1346
Query: 474 GSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELR-EIKEGQSH 532
++E +S + + A NL+ + L ++ + +
Sbjct: 1347 QLEEERNSLQ--------------------DQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 533 LED------SMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN---EMTNL 583
L+D ++E+ K + Q++ +TQ +E+ Y++LE+ N L + + ++ N
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 584 KQELASMEEK 593
+Q ++++E+K
Sbjct: 1447 RQLVSNLEKK 1456
Score = 32.7 bits (73), Expect = 1.2
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 28/135 (20%)
Query: 505 KSNALYGAPGNLDALLEE----LREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERY 560
K L A LD + + L++I+E + H+ D ED L ER
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED---------------LDSERA 1139
Query: 561 RYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE--AVESCL---TR 615
+ E+Q DL E E+ LK EL + A Q RA+ QE ++ L TR
Sbjct: 1140 ARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 616 VTKLELQQQQQQVVQ 630
+ ++Q+ +Q+ Q
Sbjct: 1196 SHEAQVQEMRQKHAQ 1210
Score = 32.0 bits (71), Expect = 2.0
Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 522 ELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRY----ERLEEQLNDLTELHQ 577
EL+E+++ S L + L+ QLQ + T + +E R R + LEE L+++ E
Sbjct: 881 ELKELEQKHSQLTEEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEM-EARL 938
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLE 632
E + Q+L + +K+A Q + ++E E + +LE + ++ +LE
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLE 991
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/142 (23%), Positives = 60/142 (42%), Gaps = 18/142 (12%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN 578
L ELR + + + +E + L+ Q+Q ++C ER R E LND QN
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQE---LQSKCSDGERARAE-----LNDKVHKLQN 1294
Query: 579 EMTNLKQELASMEEK----------VAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
E+ ++ L E K ++ Q + +QE L TKL ++++
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 629 VQLEGVENANARALLGKFINVI 650
+Q + E A+ L + I+ +
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTL 1376
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 46.2 bits (108), Expect = 1e-04
Identities = 83/390 (21%), Positives = 161/390 (41%), Gaps = 56/390 (14%)
Query: 274 DVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIK 333
DV + +++K A++ +++ E+++ E +A +D L++ A K Q R
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDL 1580
Query: 334 QVFEKKNQKSAQTIAQLHKKLEHYRRRLK-EIEQNGPSRQPKDVLRDMQQGLKDVGANVR 392
Q +++N++ + QL ++L Y L+ E +Q + K + ++ LKD+
Sbjct: 1581 QARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAK---KKLEGDLKDLELQAD 1634
Query: 393 AGISGFGGGV--VEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLE 450
+ I G + + ++ + + A S+ FA+ N+ + A L E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 451 DGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALY 510
D E AR + +E + ASS NAL
Sbjct: 1695 DLAAAERARKQADL----------EKEELAEELASSLSG----------------RNALQ 1728
Query: 511 GAPGNLDALLEEL-REIKEGQSHLEDSMEDLK------TQLQRDYTYMTQCLQEERYRYE 563
L+A + +L E++E Q ++E + ++ QL + Q+ +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 564 RLEEQLNDL-TELHQNE---MTNLKQELASMEEKVAY---QSYERARDIQEAVESCLTRV 616
+LE Q +L ++LH+ E + K +A++E K+A Q + AR+ Q A +S +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 617 TK-----LELQQQQQQVVQL-EGVENANAR 640
K L+++ +++ Q E E NAR
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Score = 33.9 bits (76), Expect = 0.53
Identities = 58/310 (18%), Positives = 129/310 (41%), Gaps = 47/310 (15%)
Query: 306 EQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIE 365
+QE R E L D++ S QV E + QK AQ + +L ++LE ++R ++
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 366 QNGPSRQPKD--------VLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQAT 417
+N + + ++ VL +Q ++ + A + +G + L+
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKV 1282
Query: 418 HTAVVSKPREFASLIRNKFGSA----DNIAHLKDPLEDGPPEEAARALSGSATLVSSPKY 473
H + ++ ++ G A ++A L L+D +E + + VS+
Sbjct: 1283 HK-LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD--TQELLQEETRQKLNVSTKLR 1339
Query: 474 GSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELR-EIKEGQSH 532
++E +S + + A NL+ + L ++ + +
Sbjct: 1340 QLEEERNSLQ--------------------DQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 533 LED------SMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN---EMTNL 583
L+D ++E+ K + Q++ +TQ +E+ Y++LE+ N L + + ++ N
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 584 KQELASMEEK 593
+Q ++++E+K
Sbjct: 1440 RQLVSNLEKK 1449
Score = 32.7 bits (73), Expect = 1.2
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 28/135 (20%)
Query: 505 KSNALYGAPGNLDALLEE----LREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERY 560
K L A LD + + L++I+E + H+ D ED L ER
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED---------------LDSERA 1132
Query: 561 RYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE--AVESCL---TR 615
+ E+Q DL E E+ LK EL + A Q RA+ QE ++ L TR
Sbjct: 1133 ARNKAEKQKRDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 616 VTKLELQQQQQQVVQ 630
+ ++Q+ +Q+ Q
Sbjct: 1189 SHEAQVQEMRQKHAQ 1203
Score = 32.0 bits (71), Expect = 2.0
Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 522 ELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRY----ERLEEQLNDLTELHQ 577
EL+E+++ S L + L+ QLQ + T + +E R R + LEE L+++ E
Sbjct: 874 ELKELEQKHSQLTEEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEM-EARL 931
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLE 632
E + Q+L + +K+A Q + ++E E + +LE + ++ +LE
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLE 984
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/142 (23%), Positives = 60/142 (42%), Gaps = 18/142 (12%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQN 578
L ELR + + + +E + L+ Q+Q ++C ER R E LND QN
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQE---LQSKCSDGERARAE-----LNDKVHKLQN 1287
Query: 579 EMTNLKQELASMEEK----------VAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
E+ ++ L E K ++ Q + +QE L TKL ++++
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 629 VQLEGVENANARALLGKFINVI 650
+Q + E A+ L + I+ +
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTL 1369
>gi|46852390 coiled-coil domain containing 6 [Homo sapiens]
Length = 474
Score = 44.3 bits (103), Expect = 4e-04
Identities = 45/216 (20%), Positives = 90/216 (41%), Gaps = 31/216 (14%)
Query: 461 LSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALL 520
++ SA+ + G + S+A SS + S G G GG G KS + +P L+ L
Sbjct: 1 MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT 60
Query: 521 EELREIKEGQSHLEDSMEDLKTQ---LQRD--------YTYMTQCLQEERY-------RY 562
L +++ L+ +E K + LQ + T + QEE + +
Sbjct: 61 NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI 120
Query: 563 ERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE----AVESCLTRVTK 618
+ L+++ L ++ E L EL+ ++ ++ E + +++ V + ++ K
Sbjct: 121 QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK 180
Query: 619 LE---------LQQQQQQVVQLEGVENANARALLGK 645
LE L+Q +++ + LE AL+ +
Sbjct: 181 LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNR 216
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/199 (23%), Positives = 88/199 (44%), Gaps = 29/199 (14%)
Query: 458 ARALSGSATLVSSP-KYGSDDE----------CSSASASSAGAGSNSGAGPGGALGSPKS 506
A +L +A+L S+ ++G +D+ AS S +G S+SG GP G
Sbjct: 98 ATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGP--FAGGEVD 155
Query: 507 NALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLE 566
L+ L L L + + +S +E S K ++++D + +EER R E
Sbjct: 156 KRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLE--- 212
Query: 567 EQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQ 626
E+ L++++A + ++ Q ++RA+ +++ + + R + LQ+++
Sbjct: 213 -----------GELKGLQEQIAETKARLITQQHDRAQ--EQSDHALMLRELQKLLQEERT 259
Query: 627 QVVQLEGVENANARALLGK 645
Q LE AL G+
Sbjct: 260 QRQDLELRLEETREALAGR 278
Score = 38.9 bits (89), Expect = 0.017
Identities = 22/110 (20%), Positives = 61/110 (55%), Gaps = 3/110 (2%)
Query: 516 LDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
++ L EL+ I++ ++ + +++L+ + R ++ LQ+E + E+QL +++
Sbjct: 299 VEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQV 358
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERARD-IQEAVESCLTRVTKLELQQQ 624
+ + L+ +++ + E + +YE+A+ Q A++ R+ +L+L+ +
Sbjct: 359 EEQRVAALENQISEVSELLG--TYEKAKQKDQLAIQKLKERILQLDLENK 406
Score = 30.0 bits (66), Expect = 7.7
Identities = 34/144 (23%), Positives = 58/144 (40%), Gaps = 14/144 (9%)
Query: 500 ALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEER 559
A K+ ALY L L EE K + S L ++ + L E +
Sbjct: 470 AADGEKATALYYQQ-ELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELK 528
Query: 560 YRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERAR------------DIQE 607
+Y L +L HQ E + KQELA +++ + Q ER + ++ +
Sbjct: 529 EKYISLRLSCEELEHQHQQEADDWKQELARLQQ-LHRQELERCQLDFRDRTLKLEEELHK 587
Query: 608 AVESCLTRVTKLELQQQQQQVVQL 631
+ L +T+ +L+ +Q + V L
Sbjct: 588 QRDRALAVLTEKDLELEQLRSVAL 611
>gi|50409756 SRp25 nuclear protein isoform 1 [Homo sapiens]
Length = 360
Score = 43.5 bits (101), Expect = 7e-04
Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 9/159 (5%)
Query: 36 GETTGANSAGGPTSDAGAAAAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFH--SRRR 93
G T + A P+ A + AAP P S P L+K + G G + H SR+R
Sbjct: 74 GVRTKGSGAALPSRPA-SRAAPRPEASSPPLPLEKARGGLSGPQGGRARGAMAHVGSRKR 132
Query: 94 SREREHQTSQDSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQ 153
SR R + S++ +++ S D+ S R + + P R Q
Sbjct: 133 SRSRSRSRGRGSEKRKKK---SRKDTSRNCSASTSQGRKASTAPGAEASPSPCITERSKQ 189
Query: 154 QIRSRPSIKRGASLHSSSGGGSSGSSSRRTKSSSLEPQR 192
+ R R R +S SSS SS SSS + SSS + ++
Sbjct: 190 KARRRT---RSSSSSSSSSSSSSSSSSSSSSSSSSDGRK 225
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 43.1 bits (100), Expect = 9e-04
Identities = 82/396 (20%), Positives = 165/396 (41%), Gaps = 73/396 (18%)
Query: 283 QRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQK 342
QR KA +D + K+ ++ KI++ A N E L++ +K+Q+ + Q E +K
Sbjct: 1093 QRAKAMVDK-ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV-KK 1150
Query: 343 SAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGL---KDVGANVRAGISGFG 399
AQ ++ ++ Y R +KE+ Q ++ K + D++Q + K ++ I+
Sbjct: 1151 DAQQTTLMNMEIADYERLMKELNQKLTNKNNK--IEDLEQEIKIQKQKQETLQEEITSLQ 1208
Query: 400 GGVVEG------------------------------VKGSLSGLSQATHTAVVSKPREFA 429
V + ++ SL G +A+ V + A
Sbjct: 1209 SSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLA 1268
Query: 430 SLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGA 489
+ K + HLK E+ R LS V++ +EC +A A A
Sbjct: 1269 EITSEKHKIHE---HLKT-----SAEQHQRTLSAYQQRVTA----LQEECRAAKAEQATV 1316
Query: 490 GS---NSGAGPGGALGSPKSNALYGAP--------GNLDALLEELR-EIKEGQSHLEDSM 537
S + L K+ ++ A +L+ L+++L+ ++++ Q++L+ ++
Sbjct: 1317 TSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINV 1376
Query: 538 EDLKTQLQRDYTYM----TQCLQEERYRYERLEEQLNDLTE---LHQNEMTNLKQELASM 590
+L+T LQ ++ + + LQE + L E+L + + ++E T +L S
Sbjct: 1377 SELQT-LQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1435
Query: 591 EEKVAYQSYERARDIQE----AVESCLTRVTKLELQ 622
E + ++ R +QE VE+ +++K+E Q
Sbjct: 1436 NEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQ 1471
Score = 36.6 bits (83), Expect = 0.082
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 17/111 (15%)
Query: 526 IKEGQSHLEDSMEDLKTQ---LQRDYTYM----------TQCLQEERY-RYERLEEQLND 571
+ E HLED++++L++Q L+ + TYM Q +++E + E LE ++N+
Sbjct: 330 VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 389
Query: 572 LTELHQNE---MTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKL 619
L + + + LK ELA + ++ Y + R++Q E +++L
Sbjct: 390 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Score = 33.9 bits (76), Expect = 0.53
Identities = 33/160 (20%), Positives = 67/160 (41%), Gaps = 15/160 (9%)
Query: 515 NLDALLEELREIKEGQS----HLEDSMEDLKTQLQRDYTYMTQCLQEERYRYER----LE 566
N+ L EE+ +I+ G +L+ ++ + + T + ++ Y++ L+
Sbjct: 179 NVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQ 238
Query: 567 EQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQ 626
E+L L +HQ E+ +EL E A + + E E+ + + E Q++
Sbjct: 239 EELLQLKAIHQEEV----KELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKK 294
Query: 627 QVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIAN 666
+LE + A + A N I +++ FV + N
Sbjct: 295 YECELENLRKATSNA---NQDNQICSILLQENTFVEQVVN 331
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 43.1 bits (100), Expect = 9e-04
Identities = 71/377 (18%), Positives = 153/377 (40%), Gaps = 65/377 (17%)
Query: 283 QRTKAAIDHLHQKILK-------------ITEQIKIEQ--EARDDNVAEYLKLANNADKQ 327
+R ++H +++K +T+Q IE+ + +DN+ K K
Sbjct: 486 ERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQK------KW 539
Query: 328 QVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDV 387
+ + Q+ K +++ + I +L L+ + +K + ++ D+L+ +Q
Sbjct: 540 TLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQ------ 593
Query: 388 GANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKD 447
V +SG V++ ++ +LS L E L+R+
Sbjct: 594 ---VSPPVSGLQKVVLDVLRHALSWLE------------EVEQLLRDL-----------G 627
Query: 448 PLEDGPPEEAARALSGSATLVSSPKY----GSDDECSSASASSAGAGSNSGAGPGGALGS 503
L P ++ + SG++ + ++ K G + E A + G + G G
Sbjct: 628 ILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGG 687
Query: 504 PKSNALYGAPGNL--DALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYR 561
N + L EE + ++E +S L + L + ++ + + L+EE+ R
Sbjct: 688 KALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTR 747
Query: 562 YERLEEQLNDLTELHQNEMTNLKQEL--ASMEEKVAYQSYE----RARDIQEAVESCLTR 615
+ LEE+L E+ ++ + + K++ A EK Q E + ++I E+ + R
Sbjct: 748 VQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
Query: 616 VTKLELQQQQQQVVQLE 632
K +++++++V LE
Sbjct: 808 KAKEAMEKEKKKVQDLE 824
Score = 31.2 bits (69), Expect = 3.5
Identities = 29/123 (23%), Positives = 62/123 (50%), Gaps = 14/123 (11%)
Query: 521 EELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQC--LQEERYRYERLEEQLNDLTELHQN 578
E+++++KE SHL+ +D QL+ ++C L+EE + E+ +L E +
Sbjct: 361 EQVQQLKEEVSHLKSQNKDKDHQLE---ALGSRCSVLKEEL----KQEDAHRELREAQEK 413
Query: 579 EMTNLKQELASMEEKVAYQSYERARDI--QEAVESCLTRVTKLELQQQQ---QQVVQLEG 633
E+ K ++ ME+++ E + Q + L +K+E + Q+ ++++QL+
Sbjct: 414 ELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQE 473
Query: 634 VEN 636
+ N
Sbjct: 474 MGN 476
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/125 (24%), Positives = 67/125 (53%), Gaps = 11/125 (8%)
Query: 534 EDSMEDLKTQLQRDYTYMTQCLQE-ERYRYERLE--EQLNDLTELHQNEMTNLKQELASM 590
ED +++L+ QL+ ++ + + L E E+Y+ + L+ +Q+ ++H+ + +QE +
Sbjct: 3342 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANTE 3400
Query: 591 EEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVV-------QLEGVENANARALL 643
+K ++ + D+Q +E +V KL+L+ Q+ Q + +LE E +R +L
Sbjct: 3401 GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3460
Query: 644 GKFIN 648
+ +N
Sbjct: 3461 YQNLN 3465
Score = 32.3 bits (72), Expect = 1.6
Identities = 29/138 (21%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDL---TEL 575
L+ E+ ++K+ Q L +S + T + + L++E LE+++ +L TEL
Sbjct: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERA--RDIQEAVESCLTRVTKLELQQQQQQVVQLEG 633
+ +M K++ ++EK A E + +D ++ +E L T + Q+++++ L+
Sbjct: 755 LEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV---SQEERLIFLDS 808
Query: 634 VENANARALLGKFINVIL 651
+++ + ++ K I +++
Sbjct: 809 IKSKSKDSVWEKEIEILI 826
Score = 32.0 bits (71), Expect = 2.0
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 6/75 (8%)
Query: 524 REIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLN-DLTELHQNEMTN 582
R+ E L ++E+L+ + +D + T +Q +R EQL +L E++ ++
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQ 447
Query: 583 LKQEL-----ASMEE 592
+KQEL A MEE
Sbjct: 448 MKQELIRQHMAQMEE 462
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/93 (24%), Positives = 46/93 (49%), Gaps = 7/93 (7%)
Query: 297 LKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEH 356
L + Q++ E++A D E L ++Q+ + ++ E KN++ Q QL + +
Sbjct: 2185 LSLEVQLQAERDAIDRKEKEITNL-----EEQLEQFREELENKNEEVQQLHMQLEIQKKE 2239
Query: 357 YRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGA 389
RL+E+EQ ++ KD + + +K+ A
Sbjct: 2240 STTRLQELEQE--NKLFKDDMEKLGLAIKESDA 2270
Score = 30.8 bits (68), Expect = 4.5
Identities = 27/123 (21%), Positives = 56/123 (45%), Gaps = 12/123 (9%)
Query: 522 ELREIKEGQSHLEDSMEDL------KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
+ RE+++ +HL++ + K QLQRD + +++ +R LE+ L L
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL--LVSA 2164
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVE 635
+ ++ ++E K + + ++A++ +T LE Q +Q + E +E
Sbjct: 2165 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR----EELE 2220
Query: 636 NAN 638
N N
Sbjct: 2221 NKN 2223
Score = 30.8 bits (68), Expect = 4.5
Identities = 17/73 (23%), Positives = 41/73 (56%), Gaps = 5/73 (6%)
Query: 555 LQEERYRYERLEEQL----NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVE 610
L + + E+L+E+L ++T L Q +++ ++ LA +EK++ E ++QE+ +
Sbjct: 2705 LASYKEKAEKLQEELLVKETNMTSL-QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2763
Query: 611 SCLTRVTKLELQQ 623
+C+ ++L +
Sbjct: 2764 ACMFEPLPIKLSK 2776
Score = 30.0 bits (66), Expect = 7.7
Identities = 24/111 (21%), Positives = 56/111 (50%), Gaps = 11/111 (9%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLN-DLTELHQ 577
LL+E ++ + + ++ E ++ LQ+ + ++E+ R+ LE++ N +L +L Q
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ 2053
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
L+++L M + + Q+ +R + V + E+Q+ +QQ+
Sbjct: 2054 QNQA-LEKQLEKMRKFLDEQAIDREHE---------RDVFQQEIQKLEQQL 2094
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/125 (24%), Positives = 67/125 (53%), Gaps = 11/125 (8%)
Query: 534 EDSMEDLKTQLQRDYTYMTQCLQE-ERYRYERLE--EQLNDLTELHQNEMTNLKQELASM 590
ED +++L+ QL+ ++ + + L E E+Y+ + L+ +Q+ ++H+ + +QE +
Sbjct: 3334 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANTE 3392
Query: 591 EEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVV-------QLEGVENANARALL 643
+K ++ + D+Q +E +V KL+L+ Q+ Q + +LE E +R +L
Sbjct: 3393 GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3452
Query: 644 GKFIN 648
+ +N
Sbjct: 3453 YQNLN 3457
Score = 32.3 bits (72), Expect = 1.6
Identities = 29/138 (21%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDL---TEL 575
L+ E+ ++K+ Q L +S + T + + L++E LE+++ +L TEL
Sbjct: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERA--RDIQEAVESCLTRVTKLELQQQQQQVVQLEG 633
+ +M K++ ++EK A E + +D ++ +E L T + Q+++++ L+
Sbjct: 755 LEKQM---KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV---SQEERLIFLDS 808
Query: 634 VENANARALLGKFINVIL 651
+++ + ++ K I +++
Sbjct: 809 IKSKSKDSVWEKEIEILI 826
Score = 32.0 bits (71), Expect = 2.0
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 6/75 (8%)
Query: 524 REIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLN-DLTELHQNEMTN 582
R+ E L ++E+L+ + +D + T +Q +R EQL +L E++ ++
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQ 447
Query: 583 LKQEL-----ASMEE 592
+KQEL A MEE
Sbjct: 448 MKQELIRQHMAQMEE 462
Score = 31.2 bits (69), Expect = 3.5
Identities = 30/123 (24%), Positives = 57/123 (46%), Gaps = 20/123 (16%)
Query: 522 ELREIKEGQSHLEDSMEDL------KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
+ RE+++ +HL++ + K QLQRD +QE E+LE ++ EL
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRD-------IQERNEEIEKLEFRVR---EL 2156
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVE 635
Q + ++ ++E K + + ++A++ +T LE Q +Q + E +E
Sbjct: 2157 EQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR----EELE 2212
Query: 636 NAN 638
N N
Sbjct: 2213 NKN 2215
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/93 (24%), Positives = 46/93 (49%), Gaps = 7/93 (7%)
Query: 297 LKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEH 356
L + Q++ E++A D E L ++Q+ + ++ E KN++ Q QL + +
Sbjct: 2177 LSLEVQLQAERDAIDRKEKEITNL-----EEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231
Query: 357 YRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGA 389
RL+E+EQ ++ KD + + +K+ A
Sbjct: 2232 STTRLQELEQE--NKLFKDDMEKLGLAIKESDA 2262
Score = 30.8 bits (68), Expect = 4.5
Identities = 17/73 (23%), Positives = 41/73 (56%), Gaps = 5/73 (6%)
Query: 555 LQEERYRYERLEEQL----NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVE 610
L + + E+L+E+L ++T L Q +++ ++ LA +EK++ E ++QE+ +
Sbjct: 2697 LASYKEKAEKLQEELLVKETNMTSL-QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755
Query: 611 SCLTRVTKLELQQ 623
+C+ ++L +
Sbjct: 2756 ACMFEPLPIKLSK 2768
Score = 30.0 bits (66), Expect = 7.7
Identities = 24/111 (21%), Positives = 56/111 (50%), Gaps = 11/111 (9%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLN-DLTELHQ 577
LL+E ++ + + ++ E ++ LQ+ + ++E+ R+ LE++ N +L +L Q
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ 2053
Query: 578 NEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
L+++L M + + Q+ +R + V + E+Q+ +QQ+
Sbjct: 2054 QNQA-LEKQLEKMRKFLDEQAIDREHE---------RDVFQQEIQKLEQQL 2094
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 42.4 bits (98), Expect = 0.002
Identities = 72/359 (20%), Positives = 154/359 (42%), Gaps = 37/359 (10%)
Query: 289 IDHLHQKILKITEQIKIEQEAR----DDNVAEYLKL-----ANNADKQQVSRIKQVFEKK 339
++ L++ I K+ K+ QEA DD E KL AN +QQV ++ E++
Sbjct: 994 VEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQE 1053
Query: 340 NQKSAQTIAQLHK---KLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANV--RAG 394
+ +LHK L+ R ++ +E + R + LR + L + + V G
Sbjct: 1054 RKARMNCERELHKLEGNLKLNRESMENLESS--QRHLAEELRKKELELSQMNSKVENEKG 1111
Query: 395 ISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPP 454
+ V+ ++ + L + ++ A + R + ++A L + LE+
Sbjct: 1112 LVAQLQKTVKELQTQIKDLKEKLEAERTTR----AKMERERADLTQDLADLNERLEEVGG 1167
Query: 455 EEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPG 514
A+ K D E ++ + A +L +++L G
Sbjct: 1168 SSLAQLEITKKQETKFQKLHRDMEEATLHFETTSA----------SLKKRHADSLAELEG 1217
Query: 515 NLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTE 574
++ L + +++++ +S L+ ++DL T++++ MT+ EE+L++ T
Sbjct: 1218 QVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ----MTRAKANAEKLCTLYEERLHEAT- 1272
Query: 575 LHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEG 633
+++T L +LA+ + K+ +S E R ++E E+ + ++++ E +Q+ L G
Sbjct: 1273 AKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEK-EALINQLSR-EKSNFTRQIEDLRG 1329
Score = 35.0 bits (79), Expect = 0.24
Identities = 76/410 (18%), Positives = 159/410 (38%), Gaps = 66/410 (16%)
Query: 273 LDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRI 332
+D +GA + +R KA ++ +++ K+ +K+ +E+ ++ + LA K+++
Sbjct: 1043 VDELEGALEQER-KARMN-CERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELS 1100
Query: 333 KQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPS---------RQPKDV---LRDM 380
+ + +N+K +AQL K ++ + ++K++++ + R+ D+ L D+
Sbjct: 1101 QMNSKVENEKGL--VAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADL 1158
Query: 381 QQGLKDVGANVRAG--ISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGS 438
+ L++VG + A I+ + + + + T S + A + G
Sbjct: 1159 NERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQ 1218
Query: 439 ADNIAHLKDPLEDGPP-------------EEAARALSGSATLVSSPKYGSDDECSSASAS 485
+N+ +K LE E+ RA + + L + Y ++A
Sbjct: 1219 VENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTL--YEERLHEATAKLD 1276
Query: 486 SAGAGSNSGAGPGGALGSPKS-------------NALYGAPGNLDALLEELREIKEGQSH 532
+N A L S N L N +E+LR E ++
Sbjct: 1277 KVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETK 1336
Query: 533 LEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEE 592
+ ++ + QRD + E+ EE+ ELH+ ++ + E+
Sbjct: 1337 SQSALAHALQKAQRDCDLLR----------EQYEEEQEVKAELHRT-LSKVNAEMVQWRM 1385
Query: 593 KVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARAL 642
K +R D+++A K EL + Q+ + GV NA +L
Sbjct: 1386 KYENNVIQRTEDLEDA---------KKELAIRLQEAAEAMGVANARNASL 1426
Score = 33.1 bits (74), Expect = 0.91
Identities = 118/648 (18%), Positives = 241/648 (37%), Gaps = 112/648 (17%)
Query: 71 IQQLS-EGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDS-----PDEKE 124
I QLS E S F ++ L R + + SQ + H Q+ D D +E+E
Sbjct: 1310 INQLSREKSNFTRQIEDL-----RGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQE 1364
Query: 125 RSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSSRRTK 184
E+HR ++ + R N V+Q+ K+ ++ + G ++ R
Sbjct: 1365 VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANAR-- 1422
Query: 185 SSSLEPQRGSPHL-----LRKAPQDSSLAAILHQHQCRP-------RSSSTTDTALLLAD 232
++SLE R L L + S AA L Q Q + + ALL A
Sbjct: 1423 NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDAS 1482
Query: 233 GSNVYLLA----------------------------EEAEGIGDKVDKG-----DLVALS 259
V L+ EE + ++V +G ++ +
Sbjct: 1483 QKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK 1542
Query: 260 LPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLK 319
T+ ++L+ +GA + R ++ I H ++L+ +++ + +D+ + + +
Sbjct: 1543 KLIEEEKTEVQVTLEETEGALE--RNESKILHFQLELLEAKAELERKLSEKDEEIENFRR 1600
Query: 320 --------LANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSR 371
L ++ D + SRI+ KK K + + ++ +L R++ E ++
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEVTRLKK--KMEEDLNEMELQLSCANRQVSEATKSLGQL 1658
Query: 372 QPKDVLRDMQQGLKDV-----GANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPR 426
Q + ++D+Q L D + ++ +++ L L + T
Sbjct: 1659 QIQ--IKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEE 1716
Query: 427 EF--------------ASLIRNKFGSADNIAHLKDPLED------GPPEEAARALSGSAT 466
E SL+ K ++A ++ E+ E+A +A +A
Sbjct: 1717 ELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAAN 1776
Query: 467 LVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREI 526
L K D + + L + AL G+ + L +RE+
Sbjct: 1777 LSEELKKKQDTIAHLERTRENMEQTITDLQK--RLAEAEQMALMGSRKQIQKLESRVREL 1834
Query: 527 K---EGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNL 583
+ EG+ + +L+R +T +E++ R++ Q++ L Q ++ N
Sbjct: 1835 EGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKL----QLKVQNY 1890
Query: 584 KQ--ELASMEEKVAYQSYERAR----DIQEAVESCLTRVTKLELQQQQ 625
KQ E+A + Y++ + +++E E ++V KL+++ ++
Sbjct: 1891 KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKARE 1938
Score = 32.3 bits (72), Expect = 1.6
Identities = 27/119 (22%), Positives = 63/119 (52%), Gaps = 10/119 (8%)
Query: 515 NLDALLEELREIKEGQSHLEDSMEDLKTQLQ---RDYTYMTQCLQEERYRYERLEEQLND 571
+LD+ + E+ + +E+ + +++ QL R + T+ L + + + + L+ QL+D
Sbjct: 1612 SLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDD 1671
Query: 572 LTELHQNEMTNLKQELASMEEK--VAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
T+L+ ++LK+++A E + + E R +QE E R+++ EL + +++
Sbjct: 1672 STQLN----SDLKEQVAVAERRNSLLQSELEDLRSLQEQTERG-RRLSEEELLEATERI 1725
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/104 (37%), Positives = 62/104 (59%), Gaps = 15/104 (14%)
Query: 530 QSHL--EDSMEDLKTQLQRDYTY-MTQCLQEERYRYER----LEEQLNDLTELHQNEMTN 582
QSHL + S+ D + D +TQ L+EER ++++ LEEQL + T LH+ E+ N
Sbjct: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENET-LHK-EIHN 305
Query: 583 LKQELASMEE-----KVAYQ-SYERARDIQEAVESCLTRVTKLE 620
LKQ+L +EE ++ YQ S E+AR+++ +V+ RV + E
Sbjct: 306 LKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE 349
>gi|50511340 shootin1 isoform b [Homo sapiens]
Length = 456
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/104 (37%), Positives = 62/104 (59%), Gaps = 15/104 (14%)
Query: 530 QSHL--EDSMEDLKTQLQRDYTY-MTQCLQEERYRYER----LEEQLNDLTELHQNEMTN 582
QSHL + S+ D + D +TQ L+EER ++++ LEEQL + T LH+ E+ N
Sbjct: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENET-LHK-EIHN 305
Query: 583 LKQELASMEE-----KVAYQ-SYERARDIQEAVESCLTRVTKLE 620
LKQ+L +EE ++ YQ S E+AR+++ +V+ RV + E
Sbjct: 306 LKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE 349
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/193 (21%), Positives = 85/193 (44%), Gaps = 27/193 (13%)
Query: 500 ALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEER 559
ALG K N + NL+ EE+ ++E + L+ S E L+ ++ T + + +++
Sbjct: 210 ALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 560 YRYERLEEQLN-------------DLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQ 606
E+ +LN D +E NE+T +EL ++ + A +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL--------HKLLKEAGEAN 321
Query: 607 EAVESCLTRVTKLELQQQQQQVVQL----EGVENANARALLGKFINVILA--LMAVLLVF 660
+A++ L V + + Q +++ + ++ + +ENAN K IL+ +A +
Sbjct: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPT 381
Query: 661 VSTIANFITPLMK 673
+ +A + P MK
Sbjct: 382 AAAVAKIVKPGMK 394
Score = 33.9 bits (76), Expect = 0.53
Identities = 33/124 (26%), Positives = 65/124 (52%), Gaps = 18/124 (14%)
Query: 519 LLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELH-- 576
L ++ +++ SHL+ +E+ ++++ +T +T+ L + +R QL+ T LH
Sbjct: 837 LSSQIEKLEHEISHLKKKLEN---EVEQRHT-LTRNLDVQLLDTKR---QLDTETNLHLN 889
Query: 577 --------QNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQV 628
Q E+ LKQ L++ME +VA QS +R Q + + + + +L+Q ++QV
Sbjct: 890 TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQV 948
Query: 629 VQLE 632
L+
Sbjct: 949 NDLK 952
Score = 32.3 bits (72), Expect = 1.6
Identities = 24/114 (21%), Positives = 56/114 (49%), Gaps = 10/114 (8%)
Query: 274 DVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIK 333
DV D ++T+ ++ L +++ T ++ + +A ++ E L N +KQ ++
Sbjct: 933 DVDDLVSQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESL----NKEKQVTEEVR 987
Query: 334 QVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDV 387
+ E + ++SA+ QL KKL + +E++ + + + M+Q L ++
Sbjct: 988 KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDD-----KRRAIESMEQQLSEL 1036
>gi|239756545 PREDICTED: hypothetical protein XP_002344931 [Homo
sapiens]
Length = 427
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 448 PLEDGPPEEAARALSGS-ATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPK 505
P E GPP AA A+SGS ++ + G D A S G A PGG+LG+P+
Sbjct: 206 PGEKGPPGAAASAVSGSWLPIMLESEAGGTDAAGQAGWRSPGKSMGDAAAPGGSLGNPR 264
>gi|239751065 PREDICTED: hypothetical protein XP_002347692 [Homo
sapiens]
Length = 537
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 448 PLEDGPPEEAARALSGS-ATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPK 505
P E GPP AA A+SGS ++ + G D A S G A PGG+LG+P+
Sbjct: 316 PGEKGPPGAAASAVSGSWLPIMLESEAGGTDAAGQAGWRSPGKSMGDAAAPGGSLGNPR 374
>gi|239745511 PREDICTED: hypothetical protein XP_002343508 [Homo
sapiens]
Length = 427
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 448 PLEDGPPEEAARALSGS-ATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPK 505
P E GPP AA A+SGS ++ + G D A S G A PGG+LG+P+
Sbjct: 206 PGEKGPPGAAASAVSGSWLPIMLESEAGGTDAAGQAGWRSPGKSMGDAAAPGGSLGNPR 264
>gi|44890059 involucrin [Homo sapiens]
Length = 585
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 511 GAPGNLDALLE--ELREIKEGQ-SHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEE 567
G P NL+ + EL E +EGQ HLE ++ + +L + L+++ E E+
Sbjct: 458 GQPKNLEQEEKQLELPEQQEGQVKHLEK--QEAQLELPEQQVGQPKHLEQQEKHLEHPEQ 515
Query: 568 QLNDLTELHQNE--MTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQ 625
Q L L Q E + +L+Q+ +E+ V + + +DIQ A+ + + +E QQQ+
Sbjct: 516 QDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEHQQQK 575
Query: 626 QQV 628
Q+V
Sbjct: 576 QEV 578
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 41.6 bits (96), Expect = 0.003
Identities = 72/374 (19%), Positives = 141/374 (37%), Gaps = 76/374 (20%)
Query: 266 DTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNAD 325
+ +G +S + + A Q+ + A++ L ++ K T++ +Q + ++ L+
Sbjct: 318 EENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQ------ 371
Query: 326 KQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQ--G 383
K+ E+KN+ ++QL + L Q+ P ++ +VL D+ Q
Sbjct: 372 ------DKKCLEEKNEILQGKLSQLEEHLSQL--------QDNPPQEKGEVLGDVLQLET 417
Query: 384 LKDVGANVRAGISGFGGGV--VEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADN 441
LK A + A + V +E +G A + ++ +SLI + S N
Sbjct: 418 LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477
Query: 442 IAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGAL 501
++ K+ LE AR + A+L S
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSE------------------------------- 506
Query: 502 GSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYR 561
L L +++ + + L+ ++ + QL + Q Q R++
Sbjct: 507 --------------LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 562 YERL-------EEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLT 614
E+L E+QL ++ E + + Q+LA+ E+ ER +++
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 615 RVTKLELQQQQQQV 628
+ KLE+ QQQ QV
Sbjct: 613 KAAKLEILQQQLQV 626
Score = 38.5 bits (88), Expect = 0.022
Identities = 76/372 (20%), Positives = 146/372 (39%), Gaps = 43/372 (11%)
Query: 295 KILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFE------KKNQKSAQT-I 347
K+ + +Q+++ EARD A+ +K ++SR + + ++ Q AQ +
Sbjct: 616 KLEILQQQLQVANEARDS--AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673
Query: 348 AQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGF---GGGVVE 404
A+L +L +++ E E+ Q KD L++ Q LK+ + + +E
Sbjct: 674 AELELQLRSEQQKATEKERVA---QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
Query: 405 GVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGS 464
+ +S L T + V RE L + G A L+ E E L
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE--TEVLRRE 788
Query: 465 ATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYGA---------PGN 515
+ ++ ++ EC A S + A YGA
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRERYE-------DSQQEEAQYGAMFQEQLMTLKEE 841
Query: 516 LDALLEELREIKEG----QSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLND 571
+ +EL+E KE +SH E + + +L + + + LQ+ + + R ++ +D
Sbjct: 842 CEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD 901
Query: 572 LTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQL 631
L+ L Q +M +E+A +E V +A + QE L + +Q + + +
Sbjct: 902 LSTL-QEKMAATSKEVARLETLV-----RKAGEQQETASRELVKEPARAGDRQPEWLEEQ 955
Query: 632 EGVENANARALL 643
+G + + +A L
Sbjct: 956 QGRQFCSTQAAL 967
Score = 31.6 bits (70), Expect = 2.7
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 17/130 (13%)
Query: 520 LEELREIKEGQS-HLEDSM---EDLKT----------QLQRDYTYMTQCLQEERYRYERL 565
LEELR+ E + L +++ +DLKT QL + ++ L+E ++L
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337
Query: 566 EEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLE--LQQ 623
++ LN+LTE H ++ A +E++++ + + + ++E E ++++LE L Q
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQLEKELS-AALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 624 QQQQVVQLEG 633
Q Q +G
Sbjct: 397 LQDNPPQEKG 406
Score = 31.6 bits (70), Expect = 2.7
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 10/119 (8%)
Query: 516 LDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
L+ L +E + + L+ +E L+T+ + L ER +E ++QL+ L
Sbjct: 415 LETLKQEAATLAANNTQLQARVEMLETERGQQEAK----LLAERGHFEEEKQQLSSLITD 470
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLE--LQQQQQQVVQLE 632
Q+ ++NL Q +E++ S + V S + +T L +QQQ Q++ L+
Sbjct: 471 LQSSISNLSQ----AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/141 (21%), Positives = 71/141 (50%), Gaps = 12/141 (8%)
Query: 507 NALYGAPGNLDALLEELREIKEG---QSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYE 563
N L A GNL +E +++ E +S ++ + LK +++ + ++ + + E
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI-------E 951
Query: 564 RLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQE-AVESCLTRVTKLELQ 622
+L++++ D+ E + L+ +L +EK + E R ++E +E+ +R+T +++Q
Sbjct: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011
Query: 623 QQQQQV-VQLEGVENANARAL 642
+ + + +L + A AL
Sbjct: 1012 DEMRLMEEELRDYQRAQDEAL 1032
Score = 37.7 bits (86), Expect = 0.037
Identities = 39/156 (25%), Positives = 71/156 (45%), Gaps = 16/156 (10%)
Query: 518 ALLEELREIKEGQSHL---EDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTE 574
AL+EEL + K+ L ++ EDL + +R+ T + L+EE +++ ++L + +
Sbjct: 727 ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786
Query: 575 LHQNEMTNLKQELASMEEKVAYQSYERARD----------IQEAVESCLTRVTKLE--LQ 622
+ +E E +A +S +D +QE E R +LE +
Sbjct: 787 AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVA 846
Query: 623 QQQQQVVQLEGVENANARALLGKFINVILALMAVLL 658
Q Q+Q+ L+G + A A+ L K+ I L L+
Sbjct: 847 QLQRQIEDLKG-DEAKAKETLKKYEGEIRQLEEALV 881
Score = 37.4 bits (85), Expect = 0.048
Identities = 32/130 (24%), Positives = 65/130 (50%), Gaps = 16/130 (12%)
Query: 505 KSNALYGAPGNLDAL--LEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRY 562
KS A A GN A E++++ E +S L + +L+ QLQ + Q ++EER
Sbjct: 589 KSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQ-QNIKEER--- 644
Query: 563 ERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQ 622
ER+ L +L H ++ +E +++++++ E ++++E + K+E +
Sbjct: 645 ERMRANLEELRSQHNEKV----EENSTLQQRLEESEGELRKNLEELFQ------VKMERE 694
Query: 623 QQQQQVVQLE 632
Q Q ++ L+
Sbjct: 695 QHQTEIRDLQ 704
Score = 37.0 bits (84), Expect = 0.063
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 10/121 (8%)
Query: 516 LDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTEL 575
L+ L++L E +SHL+D L Q++ + + L+EER + L E+++ E
Sbjct: 1038 LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSRE- 1096
Query: 576 HQNEMTNLKQELASMEEKVAYQSYERAR-DIQEAVESCLTRVTKLE---LQQQQQQVVQL 631
+M L+ EL ++E+ A Q E + ++ + +R+ LE ++ VVQ+
Sbjct: 1097 ---QMEQLRNEL--LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQM 1151
Query: 632 E 632
E
Sbjct: 1152 E 1152
Score = 34.7 bits (78), Expect = 0.31
Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 11/113 (9%)
Query: 514 GNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLT 573
G + L E L ++ + + L+ +L+ ++Q QE++ E+L+E+
Sbjct: 871 GEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Query: 574 ELH--QNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQ 624
+L +NEM N + L EK+ + DI EA +R + LELQ Q
Sbjct: 931 QLRRLKNEMENERWHLGKTIEKL----QKEMADIVEA-----SRTSTLELQNQ 974
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/146 (27%), Positives = 69/146 (47%), Gaps = 26/146 (17%)
Query: 491 SNSGAGPGGALGSPKSNALYGAPGNLDALLE-ELREIKEGQSHLEDSMEDLKTQLQRDYT 549
+ AG +G P+ G LL+ +L +++E LE ED
Sbjct: 212 AQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGRED---------- 261
Query: 550 YMTQCLQEERYRYERLEEQLNDLTELHQNE-MTNLKQELASMEEKV--AYQSYERARDIQ 606
ER R LE ++ +L H+N+ +T+L QE ++++++ QS ERA ++
Sbjct: 262 --------ERLRCAELEREVAELQ--HRNQALTSLAQEAQALKDEMDELRQSSERAGQLE 311
Query: 607 EAVESCLTRVTKLELQQQQQQVVQLE 632
+ SC R+ EL++ ++QV QLE
Sbjct: 312 ATLTSCRRRLG--ELRELRRQVRQLE 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,869,398
Number of Sequences: 37866
Number of extensions: 1497055
Number of successful extensions: 15379
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 623
Number of HSP's that attempted gapping in prelim test: 12449
Number of HSP's gapped (non-prelim): 3269
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.