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Search of human proteins with 54792136
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54792136 follistatin-like 4 [Homo sapiens]
(842 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54792136 follistatin-like 4 [Homo sapiens] 1715 0.0
gi|190358520 follistatin-like 5 isoform a [Homo sapiens] 994 0.0
gi|190358522 follistatin-like 5 isoform b [Homo sapiens] 994 0.0
gi|190358524 follistatin-like 5 isoform c [Homo sapiens] 964 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 95 2e-19
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 89 2e-17
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 84 5e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 84 5e-16
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 84 5e-16
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 79 1e-14
gi|126517478 peroxidasin homolog-like [Homo sapiens] 78 4e-14
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 77 5e-14
gi|45594240 limbic system-associated membrane protein [Homo sapi... 76 1e-13
gi|224994173 roundabout 1 isoform d [Homo sapiens] 75 3e-13
gi|224994171 roundabout 1 isoform c [Homo sapiens] 75 3e-13
gi|19743806 roundabout 1 isoform b [Homo sapiens] 75 3e-13
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 75 3e-13
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 75 3e-13
gi|4506569 roundabout 1 isoform a [Homo sapiens] 75 3e-13
gi|109150416 peroxidasin [Homo sapiens] 74 6e-13
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 74 6e-13
gi|110349719 titin isoform N2-A [Homo sapiens] 73 1e-12
gi|15147240 brother of CDO [Homo sapiens] 72 2e-12
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 72 2e-12
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 72 2e-12
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 70 8e-12
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 70 8e-12
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 70 1e-11
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 70 1e-11
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 70 1e-11
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 1715 bits (4442), Expect = 0.0
Identities = 842/842 (100%), Positives = 842/842 (100%)
Query: 1 MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNE 60
MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNE
Sbjct: 1 MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNE 60
Query: 61 LLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACL 120
LLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACL
Sbjct: 61 LLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACL 120
Query: 121 LGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDSRQDPASQKRLLVE 180
LGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDSRQDPASQKRLLVE
Sbjct: 121 LGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDSRQDPASQKRLLVE 180
Query: 181 SLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYM 240
SLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYM
Sbjct: 181 SLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYM 240
Query: 241 AFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF 300
AFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF
Sbjct: 241 AFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF 300
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL
Sbjct: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
Query: 361 RCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
RCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG
Sbjct: 361 RCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
Query: 421 VDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEIQRHLKPTE 480
VDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEIQRHLKPTE
Sbjct: 421 VDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEIQRHLKPTE 480
Query: 481 KIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGV 540
KIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGV
Sbjct: 481 KIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGV 540
Query: 541 DPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPP 600
DPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPP
Sbjct: 541 DPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPP 600
Query: 601 TNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQC 660
TNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQC
Sbjct: 601 TNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQC 660
Query: 661 RQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRG 720
RQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRG
Sbjct: 661 RQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRG 720
Query: 721 EIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEP 780
EIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEP
Sbjct: 721 EIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEP 780
Query: 781 PAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVG 840
PAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVG
Sbjct: 781 PAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVG 840
Query: 841 EV 842
EV
Sbjct: 841 EV 842
>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
Length = 847
Score = 994 bits (2571), Expect = 0.0
Identities = 470/806 (58%), Positives = 617/806 (76%), Gaps = 7/806 (0%)
Query: 42 EEPRSFEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVC 101
++ ++ E +R +G + SC K+C G CV SR+TG+ EC C++ C+ Y PVC
Sbjct: 42 KQEKNQESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVC 101
Query: 102 GSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQP 161
GSDG FYENHC++HRAACL ++IT++H++DCF KGD C Y+++KN+LL LQ +
Sbjct: 102 GSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYI 161
Query: 162 LQEGDSRQ-DPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGD 220
+QE ++ D S+K+LLV+ +F+ DAD NG + +EL Q V+K+++L +DL C+
Sbjct: 162 MQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQ-VIKQEELGKDLFDCTLYV 220
Query: 221 LLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPI 280
LL++DD+N+D L L EFY AFQV+QLSL + ++S+T TVG S VL+CA+ G LRPPI
Sbjct: 221 LLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPI 280
Query: 281 IWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVP 340
IWKRN + LN LDLEDINDFG+D SLYITKVTT H+GNYTC+A G+EQ++QTH+ QVNVP
Sbjct: 281 IWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVP 340
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
PVIRVYPESQA+EPGV ASLRCHAEGIP P++ WLKNG+D++ ++SKQL+L ANGSE+HI
Sbjct: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 400
Query: 401 SSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDD 460
S+VRYEDTGAYTCIAKNE GVDEDISSLF+EDSARKTLANILWREEGL +GNMFYVF +D
Sbjct: 401 SNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYED 460
Query: 461 GIIVIHPVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPA 520
GI VI P++CE QRH+KP+EK+ +E+CP+ E + Q C W SAVNV++++IYVAQP
Sbjct: 461 GIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPT 520
Query: 521 LSRVLVVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTG 580
L RVL+VD+Q+QKV+Q++ DP+P KL YDKSHDQVWVLSWG + K+ P+LQVIT AS
Sbjct: 521 LDRVLIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGN 580
Query: 581 QSQHLIRT-----PFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTI 635
H I T F VDDFFIP T LII H+RFGFI +K + A+ K+DLETM +KTI
Sbjct: 581 VPHHTIHTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTI 640
Query: 636 GLHHHGCVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTS 695
L + CVPQ++A+THLGGY+FI C+ DS + + Q++VD VTDSV+G N DVTGTP+ S
Sbjct: 641 NLKDYKCVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVS 700
Query: 696 PDGRFIVSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAAL 755
PDG ++VS + VQ IT+RGEIQ +D+ N ISDLAFQ SFTE++QYNIY +
Sbjct: 701 PDGHYLVSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSS 760
Query: 756 HTEPDLLFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFL 815
T+ D+LF+ELS+GKV M+K+LKEP PW +R ++DSGLFGQYL+TP+++SLF+
Sbjct: 761 STQTDVLFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFI 820
Query: 816 INGRQNTLRCEVSGIKGGTTVVWVGE 841
++GR N L CE++ ++ G TV+WVG+
Sbjct: 821 LDGRLNKLNCEITEVEKGNTVIWVGD 846
>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
Length = 846
Score = 994 bits (2569), Expect = 0.0
Identities = 470/800 (58%), Positives = 613/800 (76%), Gaps = 7/800 (0%)
Query: 48 EVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRF 107
E +R +G + SC K+C G CV SR+TG+ EC C++ C+ Y PVCGSDG F
Sbjct: 47 ESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEF 106
Query: 108 YENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDS 167
YENHC++HRAACL ++IT++H++DCF KGD C Y+++KN+LL LQ + +QE ++
Sbjct: 107 YENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENEN 166
Query: 168 RQ-DPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDD 226
D S+K+LLV+ +F+ DAD NG + +EL Q V+K+++L +DL C+ LL++DD
Sbjct: 167 PNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQ-VIKQEELGKDLFDCTLYVLLKYDD 225
Query: 227 YNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG 286
+N+D L L EFY AFQV+QLSL + ++S+T TVG S VL+CA+ G LRPPIIWKRN
Sbjct: 226 FNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNN 285
Query: 287 LTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVY 346
+ LN LDLEDINDFG+D SLYITKVTT H+GNYTC+A G+EQ++QTH+ QVNVPPVIRVY
Sbjct: 286 IILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVY 345
Query: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYE 406
PESQA+EPGV ASLRCHAEGIP P++ WLKNG+D++ ++SKQL+L ANGSE+HIS+VRYE
Sbjct: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYE 405
Query: 407 DTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIH 466
DTGAYTCIAKNE GVDEDISSLF+EDSARKTLANILWREEGL +GNMFYVF +DGI VI
Sbjct: 406 DTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQ 465
Query: 467 PVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLV 526
P++CE QRH+KP+EK+ +E+CP+ E + Q C W SAVNV++++IYVAQP L RVL+
Sbjct: 466 PIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLI 525
Query: 527 VDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLI 586
VD+Q+QKV+Q++ DP+P KL YDKSHDQVWVLSWG + K+ P+LQVIT AS H I
Sbjct: 526 VDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTI 585
Query: 587 RT-----PFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHG 641
T F VDDFFIP T LII H+RFGFI +K + A+ K+DLETM +KTI L +
Sbjct: 586 HTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYK 645
Query: 642 CVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFI 701
CVPQ++A+THLGGY+FI C+ DS + + Q++VD VTDSV+G N DVTGTP+ SPDG ++
Sbjct: 646 CVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYL 705
Query: 702 VSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDL 761
VS + VQ IT+RGEIQ +D+ N ISDLAFQ SFTE++QYNIY + T+ D+
Sbjct: 706 VSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDV 765
Query: 762 LFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQN 821
LF+ELS+GKV M+K+LKEP PW +R ++DSGLFGQYL+TP+++SLF+++GR N
Sbjct: 766 LFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLN 825
Query: 822 TLRCEVSGIKGGTTVVWVGE 841
L CE++ ++ G TV+WVG+
Sbjct: 826 KLNCEITEVEKGNTVIWVGD 845
>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
Length = 837
Score = 964 bits (2493), Expect = 0.0
Identities = 460/800 (57%), Positives = 603/800 (75%), Gaps = 16/800 (2%)
Query: 48 EVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRF 107
E +R +G + SC K+C G CV SR+TG+ EC C++ C+ Y PVCGSDG F
Sbjct: 47 ESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEF 106
Query: 108 YENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDS 167
YENHC++HRAACL ++IT++H++DCF KGD C Y+++KN+LL LQ + +QE ++
Sbjct: 107 YENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENEN 166
Query: 168 RQ-DPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDD 226
D S+K+LLV+ +F+ DAD NG + +EL Q V+K+++L +DL C+ LL++DD
Sbjct: 167 PNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQ-VIKQEELGKDLFDCTLYVLLKYDD 225
Query: 227 YNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG 286
+N+D L L EFY AFQV+QLSL + ++S+T TVG S VL+CA+ G LRPPIIWKRN
Sbjct: 226 FNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNN 285
Query: 287 LTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVY 346
+ LN LDLEDINDFG+D SLYITKVTT H+GNYTC+A G+EQ++QTH+ QVNVPPVIRVY
Sbjct: 286 IILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVY 345
Query: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYE 406
PESQA+EPGV ASLRCHAEGIP P++ WLKNG+D++ ++SKQL+L ANGSE+HIS+VRYE
Sbjct: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYE 405
Query: 407 DTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIH 466
DTGAYTCIAKNE GVDEDISSLF+EDSARKT L +GNMFYVF +DGI VI
Sbjct: 406 DTGAYTCIAKNEAGVDEDISSLFVEDSARKT---------RLGIGNMFYVFYEDGIKVIQ 456
Query: 467 PVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLV 526
P++CE QRH+KP+EK+ +E+CP+ E + Q C W SAVNV++++IYVAQP L RVL+
Sbjct: 457 PIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLI 516
Query: 527 VDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLI 586
VD+Q+QKV+Q++ DP+P KL YDKSHDQVWVLSWG + K+ P+LQVIT AS H I
Sbjct: 517 VDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTI 576
Query: 587 RT-----PFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHG 641
T F VDDFFIP T LII H+RFGFI +K + A+ K+DLETM +KTI L +
Sbjct: 577 HTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYK 636
Query: 642 CVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFI 701
CVPQ++A+THLGGY+FI C+ DS + + Q++VD VTDSV+G N DVTGTP+ SPDG ++
Sbjct: 637 CVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYL 696
Query: 702 VSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDL 761
VS + VQ IT+RGEIQ +D+ N ISDLAFQ SFTE++QYNIY + T+ D+
Sbjct: 697 VSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDV 756
Query: 762 LFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQN 821
LF+ELS+GKV M+K+LKEP PW +R ++DSGLFGQYL+TP+++SLF+++GR N
Sbjct: 757 LFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLN 816
Query: 822 TLRCEVSGIKGGTTVVWVGE 841
L CE++ ++ G TV+WVG+
Sbjct: 817 KLNCEITEVEKGNTVIWVGD 836
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 95.1 bits (235), Expect = 2e-19
Identities = 75/256 (29%), Positives = 113/256 (44%), Gaps = 22/256 (8%)
Query: 176 RLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTL 235
R++ ES ++ ADG H+ K + D C ++ DD N
Sbjct: 3098 RMITESTHVEILADGQ--------MLHIKKAEVSDTGQYVCRAINVAGRDDKN------- 3142
Query: 236 REFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLE 295
F++ V PE V V T++ ++ LTC G P I W +N + D
Sbjct: 3143 --FHLNVYVPPSIEGPEREVIVETISNPVT--LTCDATGIPPPTIAWLKNHKRIENSDSL 3198
Query: 296 DINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIR--VYPESQAQ 352
++ L I + GNYTC AS E Q + L + VPP + P +
Sbjct: 3199 EVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSV 3258
Query: 353 EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYT 412
G L C+A GIP P I WLK+G +++ ++++ + ANGS L+I DTG YT
Sbjct: 3259 LLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYT 3318
Query: 413 CIAKNEVGVDEDISSL 428
C+A N G ++ I +L
Sbjct: 3319 CVATNPAGEEDRIFNL 3334
Score = 81.6 bits (200), Expect = 3e-15
Identities = 64/185 (34%), Positives = 81/185 (43%), Gaps = 5/185 (2%)
Query: 239 YMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIN 298
Y+ V ++A D TV L C P I W RNG L I
Sbjct: 3612 YLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRIL 3671
Query: 299 DFGEDDSLYITKVTTIHMGNYTCHASG-HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA 357
G L I NYTC AS + + +L VNVPP I+ P+S +
Sbjct: 3672 SGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKS 3729
Query: 358 ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
L C AEG+P PRITW K+G ++ ++ S+L NG LHI S DTG Y C+A N
Sbjct: 3730 TVLECIAEGVPTPRITWRKDGAVLAGNHAR-YSILENGF-LHIQSAHVTDTGRYLCMATN 3787
Query: 418 EVGVD 422
G D
Sbjct: 3788 AAGTD 3792
Score = 81.3 bits (199), Expect = 4e-15
Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 7/168 (4%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TV G ST + C G P + W R+G L ++ G L + K T G
Sbjct: 3446 TVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGM--VLQLLKAETEDSGK 3503
Query: 319 YTCHASGHEQLFQTH-VLQVNVPPVIRVYPESQAQEPGV--AASLRCHAEGIPMPRITWL 375
YTC AS H +L+V PP I E + V L C A GIP P++TW+
Sbjct: 3504 YTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWM 3563
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
K+G + + Q+ L G L IS+ + EDTG YTC+A + G D+
Sbjct: 3564 KDGRPLP--QTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3609
Score = 79.7 bits (195), Expect = 1e-14
Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 8/175 (4%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
VT G S L C V G P + W ++G L + + + E L + + G Y
Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMKDGHPL--IKAKGVEILDEGHILQLKNIHVSDTGRY 2361
Query: 320 TCHASGHEQLF-QTHVLQVNVPPVI---RVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
C A + + + L V+ PP I PE+ + + SL C A GIP+P ITW
Sbjct: 2362 VCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWF 2421
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
K+G VS +S + +L+ G L + ED G YTC+ +N G + I L +
Sbjct: 2422 KDGWPVS--LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 79.7 bits (195), Expect = 1e-14
Identities = 55/173 (31%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 253 DRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVT 312
+ +SV V G S L C + P I W +NG + + + + L+I K
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMIT--ESTHVEILADGQMLHIKKAE 3121
Query: 313 TIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA--ASLRCHAEGI 367
G Y C A +G + + L V VPP I PE + ++ +L C A GI
Sbjct: 3122 VSDTGQYVCRAINVAGRDD--KNFHLNVYVPPSIE-GPEREVIVETISNPVTLTCDATGI 3178
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P P I WLKN + S ++ +L+ GS+L I+ ++ D+G YTCIA N G
Sbjct: 3179 PPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Score = 78.6 bits (192), Expect = 2e-14
Identities = 57/194 (29%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 236 REFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLE 295
+++Y V S+A + S +V +G + L C +G P I W ++G + + E
Sbjct: 3234 QKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETE 3293
Query: 296 DINDFGEDDSLYITKVTTIHMGNYTCHASG----HEQLFQTHVLQVNVPPVIRVYPESQA 351
I +L I T G YTC A+ +++F L V V P IR +
Sbjct: 3294 RIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFN---LNVYVTPTIRGNKDEAE 3350
Query: 352 QEPGV---AASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
+ + + ++ C A G P P+I WLKNG+ + +S + LLA G + I + D
Sbjct: 3351 KLMTLVDTSINIECRATGTPPPQINWLKNGLPLP--LSSHIRLLAAGQVIRIVRAQVSDV 3408
Query: 409 GAYTCIAKNEVGVD 422
YTC+A N GVD
Sbjct: 3409 AVYTCVASNRAGVD 3422
Score = 77.8 bits (190), Expect = 4e-14
Identities = 59/177 (33%), Positives = 75/177 (42%), Gaps = 5/177 (2%)
Query: 245 VQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDD 304
VQ+ + D + VT V+TC G P I W +NG+ L L D
Sbjct: 3893 VQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL--LPRGDGYRILSSG 3950
Query: 305 SLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCH 363
++ I H G YTC A HV L V+ PPVI+ P L C
Sbjct: 3951 AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCE 4010
Query: 364 AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
A G P P ITW K G++V+T L + G L IS ED G Y C+A+N G
Sbjct: 4011 ATGTPSPFITWQKEGINVNTSGRNHAVLPSGG--LQISRAVREDAGTYMCVAQNPAG 4065
Score = 77.0 bits (188), Expect = 7e-14
Identities = 50/160 (31%), Positives = 78/160 (48%), Gaps = 7/160 (4%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
+G + +L C V GD P I W R G+ + I G + SL I G+YTC
Sbjct: 4363 LGGNAILNCEVKGDPTPTIQWNRKGVDIEIS--HRIRQLG-NGSLAIYGTVNEDAGDYTC 4419
Query: 322 HASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVD 380
A+ + + + L + PP+I + P G L C A G P P ITW + G
Sbjct: 4420 VATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHS 4479
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+S ++++L+N S L+I+ + EDT + C+A+N +G
Sbjct: 4480 IS--WDDRVNVLSNNS-LYIADAQKEDTSEFECVARNLMG 4516
Score = 75.9 bits (185), Expect = 1e-13
Identities = 59/202 (29%), Positives = 85/202 (42%), Gaps = 12/202 (5%)
Query: 234 TLREFYMAFQVV-QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL--N 290
T REF + V + P+ V + + STVL C G P I W+++G L N
Sbjct: 3701 TTREFILTVNVPPNIKGGPQSLV----ILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 291 FLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPES 349
+ E+ L+I G Y C A+ + + LQV+VPP I P +
Sbjct: 3757 HARYSIL----ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTN 3812
Query: 350 QAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTG 409
V +L C A GIP P I W KNG ++ ++ L + L I S +DT
Sbjct: 3813 MTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTA 3872
Query: 410 AYTCIAKNEVGVDEDISSLFIE 431
Y C N G D+ L ++
Sbjct: 3873 TYECTVTNGAGDDKRTVDLTVQ 3894
Score = 74.3 bits (181), Expect = 4e-13
Identities = 56/179 (31%), Positives = 79/179 (44%), Gaps = 15/179 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL-NFLDLEDINDFGEDDSLYITKVTTIHMG 317
TV +L C G P I WK++ + L N L +GE L + V G
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGE---LILENVVLEDSG 4235
Query: 318 NYTC---HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW 374
YTC +A+G + T L V+V P P + G L C A GIP+P++TW
Sbjct: 4236 FYTCVANNAAGEDT--HTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTW 4293
Query: 375 LKNGVDVSTQMSKQLSLLANG-SELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
N + NG SEL I V ED+G Y C A+N VG + I +++++
Sbjct: 4294 TFNNNIIPAHFDS-----VNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE 4347
Score = 72.0 bits (175), Expect = 2e-12
Identities = 59/188 (31%), Positives = 85/188 (45%), Gaps = 17/188 (9%)
Query: 253 DRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVT 312
D S V V L C V G P I+W ++G ++ D I G L I +
Sbjct: 1739 DETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR--KLVIAQAQ 1796
Query: 313 TIHMGNYTCHASG----HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA----ASLRCHA 364
+ G Y C A+ H++ F+ + V+VPP I+ S E V +L+C A
Sbjct: 1797 VSNTGLYRCMAANTAGDHKKEFE---VTVHVPPTIK---SSGLSERVVVKYKPVALQCIA 1850
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDED 424
GIP P ITWLK+ V+T L + ++G L I+ ED G YTC+A N G +
Sbjct: 1851 NGIPNPSITWLKDDQPVNTAQG-NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQ 1909
Query: 425 ISSLFIED 432
L + +
Sbjct: 1910 HIQLHVHE 1917
Score = 71.6 bits (174), Expect = 3e-12
Identities = 60/182 (32%), Positives = 84/182 (46%), Gaps = 20/182 (10%)
Query: 248 SLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLN------FLDLEDINDFG 301
SL ++ TV V L C G+ P I W ++ L+ FL+ I D
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDI- 1978
Query: 302 EDDSLYITKVTTIHMGNYTC---HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
+S I+ G Y C +++G +LF + LQV+V P I A
Sbjct: 1979 --ESAQISDA-----GIYKCVAINSAGATELFYS--LQVHVAPSISGSNNMVAVVVNNPV 2029
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A GIP P +TWLK+G VS+ S L +L+ G L ++S + DTG YTC+A N
Sbjct: 2030 RLECEARGIPAPSLTWLKDGSPVSS-FSNGLQVLSGGRILALTSAQISDTGRYTCVAVNA 2088
Query: 419 VG 420
G
Sbjct: 2089 AG 2090
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/170 (31%), Positives = 72/170 (42%), Gaps = 9/170 (5%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TV V LTC V G P + W +N + I G +L I + G
Sbjct: 2975 TVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR--TLQIIRAKVSDGGE 3032
Query: 319 YTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQ----EPGVAASLRCHAEGIPMPRIT 373
YTC A + + L V VPP I+ + G + SL C + +P P IT
Sbjct: 3033 YTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVIT 3092
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
W KNG ++ S + +LA+G LHI DTG Y C A N G D+
Sbjct: 3093 WYKNGRMITE--STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Score = 71.6 bits (174), Expect = 3e-12
Identities = 56/173 (32%), Positives = 78/173 (45%), Gaps = 9/173 (5%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L+C G P + W N + + +N E L I +V+ G Y C A
Sbjct: 4279 LSCKATGIPLPKLTWTFNNNIIP-AHFDSVNGHSE---LVIERVSKEDSGTYVCTAENSV 4334
Query: 328 QLFQT-HVLQVNVPPVIRV-YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
+ + V PPV + YP + + G A L C +G P P I W + GVD+ ++
Sbjct: 4335 GFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDI--EI 4392
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTL 438
S ++ L NGS L I ED G YTC+A NE GV E SL ++ TL
Sbjct: 4393 SHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Score = 71.2 bits (173), Expect = 4e-12
Identities = 52/171 (30%), Positives = 77/171 (45%), Gaps = 5/171 (2%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVT G VLTC + + + W+RN + + I + SL + V G
Sbjct: 530 TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLA-NLSLELKSVKFNDAGE 588
Query: 319 YTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
Y C S V L V PP + V P++Q+ G S+ C A G P P+I W N
Sbjct: 589 YHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVN 648
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSL 428
D+ S + + ++G+ L I + +D G Y C+A N G D+ S+L
Sbjct: 649 --DMFIVGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Score = 71.2 bits (173), Expect = 4e-12
Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 7/165 (4%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TV V + T L C G +P I W++NG LN ++ SL I +
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTAT 3873
Query: 319 YTC---HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y C + +G ++ +T L V VPP I P A + C A G+P P I W
Sbjct: 3874 YECTVTNGAGDDK--RTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
KNG+ + + +L++G+ + I + + G YTC+A+N G
Sbjct: 3932 KNGIRLLPR-GDGYRILSSGA-IEILATQLNHAGRYTCVARNAAG 3974
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/184 (30%), Positives = 83/184 (45%), Gaps = 9/184 (4%)
Query: 252 EDRVSVTTVTVGLSTVLTCAVHGDLRPPII-WKRNGLTLNFLDLEDINDFGEDDSLYITK 310
+D+ +V G L C V L PPII W + ++ + F S+ IT+
Sbjct: 1083 QDKPVEISVLAGEEVTLPCEVKS-LPPPIITWAKETQLIS--PFSPRHTFLPSGSMKITE 1139
Query: 311 VTTIHMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
T G Y C A+ + Q L V+VPP I+ P+ + G + C+A+G P+
Sbjct: 1140 TRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199
Query: 370 PRITWLKNGVDVSTQMSKQLSLLAN-GSELHISSVRYEDTGAYTCIAKNEVGVDEDISSL 428
P ITW K G ST + ++N L I D G YTC+A N G DE +L
Sbjct: 1200 PVITWSKGG---STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITL 1256
Query: 429 FIED 432
+++
Sbjct: 1257 HVQE 1260
Score = 70.1 bits (170), Expect = 8e-12
Identities = 54/170 (31%), Positives = 77/170 (45%), Gaps = 9/170 (5%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V VG + C G P I W + G T+ +++ D +L I + T G Y
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN--PDGTLSIDQATPSDAGIY 1239
Query: 320 TCHASGHEQLFQTHV-LQVNVPPVIRVY--PESQAQEPGVA---ASLRCHAEGIPMPRIT 373
TC A+ +T + L V PP + P + + VA C A+G P P I
Sbjct: 1240 TCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIK 1299
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
WL NG ++ T +S+L +G+ L I+SV D G Y C+A NE G E
Sbjct: 1300 WLHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTE 1348
Score = 68.6 bits (166), Expect = 2e-11
Identities = 54/172 (31%), Positives = 75/172 (43%), Gaps = 6/172 (3%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
+ V L+C G P I W ++G + + + G SL I V G+Y
Sbjct: 4090 IAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSG---SLQIAFVQPGDAGHY 4146
Query: 320 TCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG 378
TC A+ T L V+VPP IR A L C A+GIP P I W K+
Sbjct: 4147 TCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDN 4206
Query: 379 VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
V ++ + K + EL + +V ED+G YTC+A N G D SL +
Sbjct: 4207 VLLANLLGKYTA--EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 68.2 bits (165), Expect = 3e-11
Identities = 50/167 (29%), Positives = 79/167 (47%), Gaps = 11/167 (6%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+V V LTC G P + W ++G L D + G + L I+ G
Sbjct: 3539 SVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTD--QVQTLGGGEVLRISTAQVEDTGR 3596
Query: 319 YTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQ--AQEPGVAASLRCHAEGIPMPRIT 373
YTC AS G + + ++++V+VPP I E + +L C ++ +P P IT
Sbjct: 3597 YTCLASSPAGDDD--KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVIT 3654
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
WL+NG + Q + ++ +L+ G L I++ DT YTC+A N G
Sbjct: 3655 WLRNGERL--QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG 3699
Score = 67.0 bits (162), Expect = 7e-11
Identities = 55/187 (29%), Positives = 83/187 (44%), Gaps = 10/187 (5%)
Query: 242 FQVVQLSLAPEDRVS--VTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIND 299
F +Q+ +AP S + V V L C G P + W ++G ++ +
Sbjct: 2003 FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFS-NGLQV 2061
Query: 300 FGEDDSLYITKVTTIHMGNYTC---HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV 356
L +T G YTC +A+G +Q + L+V VPP I ++ +
Sbjct: 2062 LSGGRILALTSAQISDTGRYTCVAVNAAGEKQ--RDIDLRVYVPPNIMGEEQNVSVLISQ 2119
Query: 357 AASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAK 416
A L C ++ IP P +TWLK+G + + LS+ N S L I + +DTG YTC A
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPG--LSISENRSVLKIEDAQVQDTGRYTCEAT 2177
Query: 417 NEVGVDE 423
N G E
Sbjct: 2178 NVAGKTE 2184
Score = 66.6 bits (161), Expect = 9e-11
Identities = 48/180 (26%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 248 SLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLY 307
++ D ++ TV G L C G P +IWK+ G + + + L
Sbjct: 2196 NIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQ 2255
Query: 308 ITKVTTIHMGNYTCHASG-HEQLFQTHVLQVNVPPVIR---VYPESQAQEPGVAASLRCH 363
I+ Y+C AS + + LQV + P I +P G + SL C
Sbjct: 2256 ISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECE 2315
Query: 364 AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
+GIP P +TW+K+G + +K + +L G L + ++ DTG Y C+A N G+ +
Sbjct: 2316 VQGIPPPTVTWMKDGHPLI--KAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTD 2373
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/182 (26%), Positives = 79/182 (43%), Gaps = 17/182 (9%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITK 310
PED TV + T L C + I W ++G L +I +L I
Sbjct: 2582 PED----VTVILNSPTSLVCEAYSYPPATITWFKDGTPLE--SNRNIRILPGGRTLQILN 2635
Query: 311 VTTIHMGNYTCHASGHE-QLFQTHVLQVNVPPVIR--------VYPESQAQEPGVAASLR 361
+ G Y+C A+ ++ + + ++V +PP+I + P+ + +L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
C A IP ++W K+G + + +++ ANG L I + DTG YTC+A N G
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLKSD--DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGE 2753
Query: 422 DE 423
DE
Sbjct: 2754 DE 2755
Score = 64.7 bits (156), Expect = 3e-10
Identities = 60/212 (28%), Positives = 90/212 (42%), Gaps = 19/212 (8%)
Query: 250 APEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYIT 309
A D TV V S ++ C G P W+++G L D G + T
Sbjct: 2874 ANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 310 KVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVA--ASLRCHAEG 366
++T I G Y C A + + L V+VPP + + P+S+ V SL C G
Sbjct: 2934 QITDI--GRYVCVAENTAGSAKKYFNLNVHVPPSV-IGPKSENLTVVVNNFISLTCEVSG 2990
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
P P ++WLKN + +++ ++ G L I + D G YTCIA N+ G +
Sbjct: 2991 FPPPDLSWLKNEQPI--KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKF 3048
Query: 427 SLFI--------EDSARKTLANILWREEGLSV 450
SL + DS ++ N+ EG SV
Sbjct: 3049 SLTVYVPPSIKDHDSESLSVVNV---REGTSV 3077
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/174 (28%), Positives = 73/174 (41%), Gaps = 8/174 (4%)
Query: 252 EDRVSVTTVTVGLS--TVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYIT 309
+D+ VT V+V L+ T L C V G P I+W ++ + + + I L +
Sbjct: 1362 KDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT--ESSTIQTVNNGKILKLF 1419
Query: 310 KVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVI--RVYPESQAQEPGVAASLRCHAEG 366
+ T G Y+C A Q + + V VPP I +P + +L C +G
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P P I W K+G + + LL G LH+ + R D G Y C N G
Sbjct: 1480 TPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG 1532
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/163 (30%), Positives = 78/163 (47%), Gaps = 15/163 (9%)
Query: 265 STVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC--- 321
S LTC G P I W ++G ++ + I G L + + T G YTC
Sbjct: 2403 SVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVR 2460
Query: 322 HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV----AASLRCHAEGIPMPRITWLKN 377
+A+G E+ + L V VPP + E+ ++ V + +L C G P+P ITW K+
Sbjct: 2461 NAAGEER--KIFGLSVLVPP--HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKD 2516
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G + Q + +++ G L I++V+ TG YTC+A + G
Sbjct: 2517 GQPL--QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAG 2557
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/163 (30%), Positives = 72/163 (44%), Gaps = 14/163 (8%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH----A 323
L C G P I W ++G + D G+ L+I + YTCH A
Sbjct: 1567 LECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ--YLHIPRAQVSDSATYTCHVANVA 1624
Query: 324 SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA---SLRCHAEGIPMPRITWLKNGVD 380
E+ F + V VPP+I + + V A +L C A G P P +TWLK+GV
Sbjct: 1625 GTAEKSFH---VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVP 1681
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
V + + + + A G +L I S + D G Y C+A + G E
Sbjct: 1682 V--KANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGH 326
+L C G P I W++ G+ +N + L I++ G Y C A
Sbjct: 4006 LLPCEATGTPSPFITWQKEGINVNTSGRN--HAVLPSGGLQISRAVREDAGTYMCVAQNP 4063
Query: 327 EQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
+ L V VPPVI + + +L C A+G+P P ITW K+G + +
Sbjct: 4064 AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESI 4123
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
++ +L++GS L I+ V+ D G YTC+A N G + L +
Sbjct: 4124 RQR--VLSSGS-LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 11/166 (6%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V + S L C G+ P + W ++G+ + D I G+ L I I G Y
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGK--KLEIMSAQEIDRGQY 1710
Query: 320 TCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV--AASLRCHAEGIPMPRITW 374
C A +G +++ + + V VPP I E+ V L CH G P P I W
Sbjct: 1711 ICVATSVAGEKEI--KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMW 1768
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
LK+G + + +L NG +L I+ + +TG Y C+A N G
Sbjct: 1769 LKDGQLIDER--DGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812
Score = 60.8 bits (146), Expect = 5e-09
Identities = 49/159 (30%), Positives = 67/159 (42%), Gaps = 10/159 (6%)
Query: 270 CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQL 329
C G +P I W NG L + I+ + L I VT G Y C A
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGRE-PGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346
Query: 330 FQT-HVLQVNVPPVIRVYPESQAQEPGVA----ASLRCHAEGIPMPRITWLKNGVDVSTQ 384
+ + L+V+VPPVI+ + Q V +L C EG P P I W K+ V V+
Sbjct: 1347 TERKYNLKVHVPPVIK--DKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE- 1403
Query: 385 MSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
S + + NG L + ED G Y+C A N G +
Sbjct: 1404 -SSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ 1441
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/214 (23%), Positives = 86/214 (40%), Gaps = 6/214 (2%)
Query: 213 LLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAV 272
L +P D R+ + + T ++++ +V ++ + + +V + L C V
Sbjct: 1418 LFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV 1477
Query: 273 HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQT 332
G P I W ++G L FL ++ L++ G Y C S
Sbjct: 1478 KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAK 1536
Query: 333 HV-LQVNVPPVIRVYPESQAQEPGVAA--SLRCHAEGIPMPRITWLKNGVDVSTQMSKQL 389
+ L + +PP I+ + + + L C G+PMP ITW K+G + + S Q
Sbjct: 1537 DIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS--SSQA 1594
Query: 390 SLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
+ G LHI + D+ YTC N G E
Sbjct: 1595 LYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAE 1628
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/167 (31%), Positives = 75/167 (44%), Gaps = 7/167 (4%)
Query: 256 SVTTVTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTI 314
SV V G L C + G+ P W +N L + D SL+I +V
Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS---DGSLHIERVQLQ 953
Query: 315 HMGNYTCHASGHEQLF-QTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
G YTC AS +T + V+V P I+ + + G+ +L C A G P P +
Sbjct: 954 DGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 1013
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
W K G +ST +K S A+GS L++ S E++G Y C A N G
Sbjct: 1014 WSKKGELISTSSAK-FSAGADGS-LYVVSPGGEESGEYVCTATNTAG 1058
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/164 (29%), Positives = 69/164 (42%), Gaps = 6/164 (3%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L C +G P I W ++ +N ++ L I K G YTC A+
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQ-GNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 328 QLFQTHV-LQVNVPPVIRVYPESQAQEPGVA--ASLRCHAEGIPMPRITWLKNGVDVSTQ 384
Q H+ L V+ PP + + + V+ L C A G P+P ITW K+ +S
Sbjct: 1905 GETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS 1964
Query: 385 MSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSL 428
S ++ L G + I S + D G Y C+A N G E SL
Sbjct: 1965 TS--MTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSL 2006
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 9/178 (5%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGE--DDSLYITKVTTIHM 316
++ +G + L C V G P I W+R F ++ + +L+I +
Sbjct: 803 SMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDK 862
Query: 317 GNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHA-EGIPMPRI 372
G Y C A G Q T + V P+I + P G +L C G P+P
Sbjct: 863 GTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPER 922
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
W+KN + + +++ ++GS LHI V+ +D G YTC+A N G + +S+ +
Sbjct: 923 RWIKNSAMLL--QNPYITVRSDGS-LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV 977
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/178 (26%), Positives = 76/178 (42%), Gaps = 21/178 (11%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
+ V + L C + + W ++G L D +N +L I + G Y
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDD--HVNIAANGHTLQIKEAQISDTGRY 2743
Query: 320 TCHAS---GHEQLFQTHVLQVNVPPVIRVYPE----------SQAQEPGV--AASLRCHA 364
TC AS G ++L + + VPP + E +A++ + SL C
Sbjct: 2744 TCVASNIAGEDEL--DFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCET 2801
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
P P +TW K+G +++ S ++ +L G L I + ED G YTC+A NE G D
Sbjct: 2802 NAAPPPTLTWYKDGHPLTS--SDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGED 2857
Score = 56.6 bits (135), Expect = 9e-08
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 21/226 (9%)
Query: 222 LRFDDYNSDSSLTLREFYMAFQVVQLSLAPE-DRVSVTTVTVGLSTV---LTCAVHGDLR 277
L+ Y+ D L R ++F S+ P+ +V++ T G + C+V L
Sbjct: 403 LKVTGYDKDDYLFQRVSSVSFS----SIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLP 458
Query: 278 PPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHA-----SGHEQLFQT 332
+ + RNG+TL ++ +L I KVT G Y C A +G Q F
Sbjct: 459 FTLSFVRNGVTLG---VDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTF-- 513
Query: 333 HVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLL 392
V+ PP + P + PG A L C +TW +N DV ++ L
Sbjct: 514 --FDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTL 571
Query: 393 ANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTL 438
AN S L + SV++ D G Y C+ +E G L +++ + T+
Sbjct: 572 ANLS-LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTV 616
Score = 56.6 bits (135), Expect = 9e-08
Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 260 VTVGLSTVLTCAVHGDLRPP--IIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
V+V +S + D PP + W ++G L L ++ L I G
Sbjct: 2113 VSVLISQAVELLCQSDAIPPPTLTWLKDGHPL--LKKPGLSISENRSVLKIEDAQVQDTG 2170
Query: 318 NYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQE--PGVAASLRCHAEGIPMPRITW 374
YTC A+ + + + + + VPP I E G SL C + GIP P + W
Sbjct: 2171 RYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIW 2230
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
K G V T ++ +L+ G +L IS D Y+C+A N G
Sbjct: 2231 KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 56.6 bits (135), Expect = 9e-08
Identities = 55/242 (22%), Positives = 99/242 (40%), Gaps = 13/242 (5%)
Query: 186 LDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVV 245
L +D + +++++ + + Q D C ++ D+ + D ++ + + +
Sbjct: 2715 LKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEI 2774
Query: 246 QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS 305
L V + L C + P + W ++G L D I G
Sbjct: 2775 GNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGR--V 2832
Query: 306 LYITKVTTIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV----AA 358
L I + G YTC A +G + L + ++V VPP+I+ +E V +A
Sbjct: 2833 LQIPRAKVEDAGRYTCVAVNEAGEDSL--QYDVRVLVPPIIKGANSDLPEEVTVLVNKSA 2890
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
+ C + G P PR +W K+G + + L+NG L I + + D G Y C+A+N
Sbjct: 2891 LIECLSSGSPAPRNSWQKDGQPLLEDDHHKF--LSNGRILQILNTQITDIGRYVCVAENT 2948
Query: 419 VG 420
G
Sbjct: 2949 AG 2950
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/168 (29%), Positives = 71/168 (42%), Gaps = 13/168 (7%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLN---FLDLEDINDFGEDDSLYITKVTTIHM 316
V +G TV+ C G P + W + L L FL ++ + L I + +
Sbjct: 713 VALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGL-----LKIQETQDLDA 767
Query: 317 GNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW- 374
G+YTC A + L V PPV P + E G +L C+ +G P P I W
Sbjct: 768 GDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR 827
Query: 375 -LKNGVDVSTQMS-KQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
L N S S +S L G+ L I ++ D G Y C A+N+ G
Sbjct: 828 RLDNMPIFSRPFSVSSISQLRTGA-LFILNLWASDKGTYICEAENQFG 874
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/182 (26%), Positives = 70/182 (38%), Gaps = 13/182 (7%)
Query: 261 TVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYT 320
T G + C+ G +P I W N + F+ D +L+I G Y
Sbjct: 624 TGGSEVSIMCSATGYPKPKIAWTVNDM---FIVGSHRYRMTSDGTLFIKNAAPKDAGIYG 680
Query: 321 CHASGHEQLF-QTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGV 379
C AS Q L+ P + V G + C GIP P++ W K
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG-- 738
Query: 380 DVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG-----VDEDISS--LFIED 432
D+ + S L + L I + D G YTC+A NE G + D+ S +FI++
Sbjct: 739 DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798
Query: 433 SA 434
A
Sbjct: 799 PA 800
Score = 33.9 bits (76), Expect = 0.65
Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 8/105 (7%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
T + G +L C G+ +P I W R G ++++ D ++ ++SLYI
Sbjct: 4449 TVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL---SNNSLYIADAQKEDTS 4505
Query: 318 NYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRC 362
+ C A VL V VP +++V+ A S+ C
Sbjct: 4506 EFECVARN----LMGSVL-VRVPVIVQVHGGFSQWSAWRACSVTC 4545
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 89.0 bits (219), Expect = 2e-17
Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 29/210 (13%)
Query: 49 VTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFY 108
V E L S +++ C FC G C ++ K GEP C C+E C+P PVCGS+G+ Y
Sbjct: 18 VRAEEELRSKSKI---CANVFCGAGRECAVTEK-GEPTCLCIEQCKPHKRPVCGSNGKTY 73
Query: 109 ENHCKLHRAACLLGKRITVIHSKDCFLKGD--------TCTMAGYARL-KNVLLALQTRL 159
NHC+LHR ACL G +I V + C K C + L + ++ L+ +
Sbjct: 74 LNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEI 133
Query: 160 QPLQEGDSRQDPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKK-----------QD 208
P D S +++ F++ D +G+ L SSE + V + Q+
Sbjct: 134 IP----DGWFSKGSNYSEILDKYFKNFD-NGDSRLDSSEFLKFVEQNETAINITTYPDQE 188
Query: 209 LDEDLLGCSPGDLLRFDDYNSDSSLTLREF 238
++ L G L+ D N+D L+ +EF
Sbjct: 189 NNKLLRGLCVDALIELSDENADWKLSFQEF 218
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 84.0 bits (206), Expect = 5e-16
Identities = 57/163 (34%), Positives = 72/163 (44%), Gaps = 6/163 (3%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVT+ VLTC G P + W + G L +L I + IH G
Sbjct: 2676 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVSPSGALEIGQALPIHAGR 2733
Query: 319 YTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
YTC A + HV L V PV++ P L C A GIP P ITW K
Sbjct: 2734 YTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 2793
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G++V+T +S Q + G +L I+ ED G Y CIAKN G
Sbjct: 2794 GLNVATGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAG 2833
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/192 (29%), Positives = 83/192 (43%), Gaps = 9/192 (4%)
Query: 235 LREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
+R F + QV P + + G VLTC V G P + W ++ + + +
Sbjct: 1922 VRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAV 1979
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASGHE-QLFQTHVLQVNVPPVIR---VYPESQ 350
+ G L ++++ G YTC A + + + V+ V V P IR V E
Sbjct: 1980 HGVVSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 2037
Query: 351 AQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGA 410
E G L C A+G P P + WLK+G + M L +G L + +R D GA
Sbjct: 2038 VLE-GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGA 2096
Query: 411 YTCIAKNEVGVD 422
YTC+A N G D
Sbjct: 2097 YTCVAHNPAGED 2108
Score = 73.9 bits (180), Expect = 6e-13
Identities = 55/170 (32%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL--NFLDLEDINDFGEDDSLYITKVTTIHM 316
TV G T L+C G P I W+++G L L+ ++ G LY+ +
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQE 1039
Query: 317 GNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV---AASLRCHAEGIPMP 370
G YTC S G+ Q L+V+VPP I E Q V A+L C+A G P P
Sbjct: 1040 GTYTCECSNVVGNSS--QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 1097
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW ++G V ++ QL G LH+ + TG Y+C+A+N G
Sbjct: 1098 TVTWERDGQPVGAELGLQLQ--NQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 9/192 (4%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLE-DINDFGE 302
VVQ+ E+ + + T G L C G P I W ++G ++ + + I GE
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2901
Query: 303 DDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLR 361
L + + G YTC A + V L + V PV P ++ G LR
Sbjct: 2902 ---LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 2958
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
C A G P PRI W N V+ +S+Q GS L ++V ED+G Y C A+N VG
Sbjct: 2959 CAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGR 3014
Query: 422 DEDISSLFIEDS 433
+ +S + ++++
Sbjct: 3015 TQAVSFVHVKEA 3026
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/203 (31%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 237 EFYMAFQVVQLSLAPEDRVSVTT---VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLD 293
+F AF++ LS E R VT + L C + P + W R L+ D
Sbjct: 1547 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1604
Query: 294 LEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQ 352
+ G L I V + G Y+C AS H L V PPVI E +
Sbjct: 1605 EVSVLQGGR--VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1662
Query: 353 EPGVAAS----LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
E V AS L+C A G P+P I+WL+NG+ S S +L +L +G L +S+ D
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1720
Query: 409 GAYTCIAKNEVGVDEDISSLFIE 431
+Y C+A+N+ G E + +L ++
Sbjct: 1721 ASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/160 (34%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
VG S L C V GD P I W ++GL L L G SL I + G Y C
Sbjct: 3041 VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQC 3097
Query: 322 HASGHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVD 380
A + + V+ V PV +V P+ G +LRC A G P P I WL+ G
Sbjct: 3098 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3157
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ + S++L L +GS L + +V D G Y C+A N +G
Sbjct: 3158 L--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3194
Score = 71.6 bits (174), Expect = 3e-12
Identities = 58/181 (32%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 242 FQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG 301
F VQ S + SV +L C G RP I W++ GL + + G
Sbjct: 2750 FLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG 2809
Query: 302 EDDSLYITKVTTIHMGNYTCHA--SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS 359
+ L I + GNY C A S + +T ++ V VPPVI + G A
Sbjct: 2810 Q---LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAF 2865
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G P P ITW K+G VS K + EL + ++ +D G YTC A+N V
Sbjct: 2866 LPCKARGSPEPNITWDKDGQPVSGAEGK--FTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 420 G 420
G
Sbjct: 2924 G 2924
Score = 70.1 bits (170), Expect = 8e-12
Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 10/183 (5%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGED 303
+V S+ ED V V G + L C V G +P + W ++G L D I+ G
Sbjct: 1250 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV- 1308
Query: 304 DSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAA---- 358
L + + G+Y+C A+ H L V + P I E A E
Sbjct: 1309 -LLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 1367
Query: 359 -SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
SL C A P P ITW+K+G + S+ + LL L I + + ED G YTC+ N
Sbjct: 1368 ISLICEALAFPSPNITWMKDGAPF--EASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1425
Query: 418 EVG 420
E+G
Sbjct: 1426 ELG 1428
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIN-DFGEDDS-LYITKVTTIHMGNYTC--- 321
VL C+V + P I W R+G+ L ED + F E L + ++T G+Y+C
Sbjct: 2409 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2464
Query: 322 HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
+A+G + ++++ P IR P + A L C A+G+P P ++W K+ V +
Sbjct: 2465 NAAGSTSV--AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 2522
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+ S + +L GS L I V +D G Y C+A N G D
Sbjct: 2523 DPR-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 67.4 bits (163), Expect = 5e-11
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 14/185 (7%)
Query: 243 QVVQLSL--------APEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
++VQLS+ AP V VG VL+C P + W ++G L
Sbjct: 1828 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1887
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASG-HEQLFQTHVLQVNVPPVI-RVYPESQAQ 352
G+ L I + G Y+C S + +T L V VPP E+ +Q
Sbjct: 1888 TQALRGGQ--RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ 1945
Query: 353 EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYT 412
G L C G+P P +TWLK+ + V + S +++ G L +S ++ G YT
Sbjct: 1946 VAGSPLVLTCDVSGVPAPTVTWLKDRMPV--ESSAVHGVVSRGGRLQLSRLQPAQAGTYT 2003
Query: 413 CIAKN 417
C+A+N
Sbjct: 2004 CVAEN 2008
Score = 67.0 bits (162), Expect = 7e-11
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 14/188 (7%)
Query: 244 VVQLSLAPEDRVSVTT----VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIND 299
VV + +AP R S V G L C G P + W ++G L +
Sbjct: 2018 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 2077
Query: 300 FGEDDSLYITKVTTIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQA---QE 353
+ + SL + + G YTC A +G + + H + V VPP I+ +
Sbjct: 2078 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPPTIKQGADGSGTLVSR 2135
Query: 354 PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC 413
PG ++ C G P ++WLK+G+ + +S++ L +G L IS V+ D G +TC
Sbjct: 2136 PGELVTMVCPVRGSPPIHVSWLKDGLPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTC 2193
Query: 414 IAKNEVGV 421
+A + GV
Sbjct: 2194 VAASPAGV 2201
Score = 63.9 bits (154), Expect = 6e-10
Identities = 55/183 (30%), Positives = 83/183 (45%), Gaps = 17/183 (9%)
Query: 246 QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNF-LDLEDINDFGEDD 304
Q++ E V+ V G++T L C G P + W+R+G + L L+ N +
Sbjct: 1066 QIAGPREPPTQVSVVQDGVAT-LECNATGKPPPTVTWERDGQPVGAELGLQLQN---QGQ 1121
Query: 305 SLYITKVTTIHMGNYTCHASG----HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS- 359
SL++ + H G Y+C A E+ F+ VL VPP + + S
Sbjct: 1122 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---VPPELIGDLDPLTNITAALHSP 1178
Query: 360 --LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
L C A GIP P I W + VS + LLA G L ++ + +D+G Y+C+A N
Sbjct: 1179 LTLLCEAMGIPPPAIRWFRGEEPVSP--GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1236
Query: 418 EVG 420
E G
Sbjct: 1237 EAG 1239
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/134 (33%), Positives = 63/134 (47%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHA 364
L I KV G YTC A+ + V L+V VPP I P ++A + +L C A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDED 424
G+P P ++W K VS+ M +S+ +G L I + D G+Y C+A N G E
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTVSV--DGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776
Query: 425 ISSLFIEDSARKTL 438
L + R TL
Sbjct: 777 RYGLRVNVPPRITL 790
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 12/184 (6%)
Query: 252 EDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKV 311
E+ V TV + L C G+ P I W +NGL + + + G+ L ++
Sbjct: 1658 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTA 1715
Query: 312 TTIHMGNYTC----HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEG 366
+Y C A E+LF L+V VPP I Q + SL C
Sbjct: 1716 EVADAASYMCVAENQAGSAEKLF---TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHA 1772
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
P P +TW K+ +S + +++ LL L + R D+G YTC A N G D+ +
Sbjct: 1773 HPNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1830
Query: 427 SLFI 430
L +
Sbjct: 1831 QLSV 1834
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 8/162 (4%)
Query: 265 STVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS 324
S L C G P + W + ++ ++ G L I + G+Y C AS
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVAS 768
Query: 325 ---GHEQLFQTHVLQVNVPPVIRVYPESQAQE-PGVAASLRCHAEGIPMPRITWLKNGVD 380
G +L + L+VNVPP I + P L C+A G P P + WLK+G
Sbjct: 769 NVAGSTEL--RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 826
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
VS + L + G L ++S R D+G Y+C+A + VG D
Sbjct: 827 VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/170 (27%), Positives = 71/170 (41%), Gaps = 15/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T + S L C VH P + W ++ L+ E++ +L + + G
Sbjct: 1757 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGM 1814
Query: 319 YTC---HASGHEQ-LFQTHVLQVNVPPVIRVYPESQAQ----EPGVAASLRCHAEGIPMP 370
YTC +A+G +Q L Q VL VPP R P G A L C + +P P
Sbjct: 1815 YTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 1871
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G + ++++ L G L I + D G Y+C N G
Sbjct: 1872 TVTWYKDGQPL--VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1919
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/198 (29%), Positives = 80/198 (40%), Gaps = 19/198 (9%)
Query: 229 SDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLT 288
S + + R F + QV + L P + + V G L C G P + W ++G
Sbjct: 2197 SPAGVADRNFTLQVQVPPV-LEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEP 2255
Query: 289 LNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRV-- 345
L LE + SL + V G Y+C A + H L V PP I
Sbjct: 2256 LLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2309
Query: 346 YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
P + PG L C A+G P P ITW K+G + L+ L N S +R
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDG--------QALTRLENNSRA-TRVLRV 2360
Query: 406 EDTGAYTCIAKNEVGVDE 423
D G YTC+A++ G E
Sbjct: 2361 RDAGLYTCLAESPAGAIE 2378
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/172 (29%), Positives = 69/172 (40%), Gaps = 11/172 (6%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R V G L C G P + W GL + + + G L +
Sbjct: 411 RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS--VLRLESPGE 468
Query: 314 IHMGNYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEP---GVAASLRCHAEGIP 368
G Y+C AS E + Q V +V VPP + V E Q G L C A G P
Sbjct: 469 ASSGLYSCVASSPAGEAVLQYSV-EVQVPPQLLV-AEGLGQVTTIVGQPLELPCQASGSP 526
Query: 369 MPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+P I WL+NG Q++ + G+ LHI V + +G + C A NE G
Sbjct: 527 VPTIQWLQNGRPAEELAGVQVA--SQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 9/168 (5%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L CA G P I W N + E +++ +L V+ G Y C A
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 328 QLFQT-HVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
Q + V PV++ S EP G + L C G P+P I W+K+G+ + +
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL--RG 3070
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 433
S L NGS L I +D G Y C+A+NE+GV + + L ++ +
Sbjct: 3071 SHLRHQLQNGS-LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSA 3117
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/184 (28%), Positives = 74/184 (40%), Gaps = 18/184 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVTV L C P I W ++G F +I L I G
Sbjct: 1361 TVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPGTHGLQILNAQKEDAGQ 1418
Query: 319 YTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGV---------AASLRCHAEGI 367
YTC + E + HV +V +PP I + E GV +L C + +
Sbjct: 1419 YTCVVTNELGEAVKNYHV-EVLIPPSIS--KDDPLGEVGVKEVKTKVNSTLTLECESWAV 1475
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISS 427
P P I W K+G V+ S +L +L G L I + D+G Y C+A N G D+ +
Sbjct: 1476 PPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 1533
Query: 428 LFIE 431
+ I+
Sbjct: 1534 VLIQ 1537
Score = 58.2 bits (139), Expect = 3e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 308 ITKVTTIHMGN---YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA----AS 359
+ ++T H+G+ Y C A S Q + L+V+ PP I + ++ E V
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI--WGSNETGEVAVMEDHLVQ 330
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G+P P ITW K+G + T S ++ G +L + + D G YTC A N V
Sbjct: 331 LLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV 388
Query: 420 GVDEDISSL 428
G E + L
Sbjct: 389 GAAEKATRL 397
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 10/200 (5%)
Query: 226 DYNSDSSLTLREFYMAFQVVQLSLAPEDRVS--VTTVTVGLSTVLTCAVHGDLRPPIIWK 283
DY+ + +AF+V ++ P R V+V + +L C G P + W+
Sbjct: 2458 DYSCTARNAAGSTSVAFRV-EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWR 2516
Query: 284 RNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVP 340
++ + L+ + + SL I V G+Y C AS G ++ Q L+V P
Sbjct: 2517 KDRVPLD--PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEP 2572
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P I P + A L C A G P P + W K+G + ++ + L + L +
Sbjct: 2573 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 2632
Query: 401 SSVRYEDTGAYTCIAKNEVG 420
++ +D+ + C+ NEVG
Sbjct: 2633 TAPGPQDSAQFECVVSNEVG 2652
Score = 57.4 bits (137), Expect = 5e-08
Identities = 40/164 (24%), Positives = 66/164 (40%), Gaps = 3/164 (1%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T+T +L C G +P ++W ++G L+F + ++L +T
Sbjct: 2583 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2642
Query: 319 YTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
+ C S + + + + V+VPP I L CH+ GIP P ++W K
Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
G + + S ++ L I G YTC A+N GV
Sbjct: 2703 GAQLGARGSGYR--VSPSGALEIGQALPIHAGRYTCSARNSAGV 2744
Score = 57.0 bits (136), Expect = 7e-08
Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 3/165 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V V LTC G P ++W ++G ++ + F L + G Y
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 320 TCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG 378
+C A S + Q VLQV++PP I + + + +L C + +P P ++W K+G
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 917
Query: 379 VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
+ + LS A+ + L + D G YTC A N+ G E
Sbjct: 918 RPLEPRPGVHLS--ADKALLQVDRADVWDAGHYTCEALNQAGRSE 960
Score = 57.0 bits (136), Expect = 7e-08
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 4/164 (2%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+V S L C H P + W ++G L ++ + L + + G+
Sbjct: 890 SVVANESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVHLSADKALLQVDRADVWDAGH 947
Query: 319 YTCHASGHEQLFQTHV-LQVNVPPVIRVYPE-SQAQEPGVAASLRCHAEGIPMPRITWLK 376
YTC A + H L V V PV + + G SL C G+P P+I+W K
Sbjct: 948 YTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK 1007
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+G + + + + A G L++ + G YTC N VG
Sbjct: 1008 DGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 1051
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 16/166 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
++T G L C G +P I W ++G L L E++S + G
Sbjct: 2315 SLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGL 2365
Query: 319 YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS---LRCHAEGIPMPRITW 374
YTC A S + ++ ++V PP I V P G+A L C E P P+ITW
Sbjct: 2366 YTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW 2424
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++G+ + Q G L + ++ D+G Y+C A+N G
Sbjct: 2425 HRDGIVLQEDAHTQFP--ERGRFLQLQALSTADSGDYSCTARNAAG 2468
Score = 51.6 bits (122), Expect = 3e-06
Identities = 47/169 (27%), Positives = 72/169 (42%), Gaps = 9/169 (5%)
Query: 257 VTTVTVGLSTVLT--CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTI 314
+T +T L + LT C G P I W R ++ ED L +T+
Sbjct: 1168 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMTQTQEQ 1225
Query: 315 HMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQE--PGVAASLRCHAEGIPMPR 371
G Y+C AS + + ++V VPP I + + G A L C+ G P P+
Sbjct: 1226 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1285
Query: 372 ITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G ++ + +S +G L + G Y+CIA N VG
Sbjct: 1286 LTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHYSCIAANAVG 1332
Score = 51.2 bits (121), Expect = 4e-06
Identities = 52/197 (26%), Positives = 75/197 (38%), Gaps = 31/197 (15%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPP--IIWKRNGLTLNFLDLEDINDFGEDDSLYI 308
P V V V +++ LT PP I W ++G + + GE L I
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQI 1506
Query: 309 TKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIR----------VYPESQAQEPG 355
G Y C A+ G + Q + + VPP+ + + + G
Sbjct: 1507 QPTQVSDSGRYLCVATNVAGEDD--QDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1564
Query: 356 VA----------ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
V A L C IP P +TW + +S ++S+L G L I VR
Sbjct: 1565 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRA 1622
Query: 406 EDTGAYTCIAKNEVGVD 422
E+ G Y+C A NEVG D
Sbjct: 1623 ENAGRYSCKASNEVGED 1639
Score = 50.4 bits (119), Expect = 7e-06
Identities = 40/122 (32%), Positives = 56/122 (45%), Gaps = 7/122 (5%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
+TVGL C HG +P + W R G + L + E+ SL++ V+ G+Y
Sbjct: 15 LTVGLEAG-GCGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDY 72
Query: 320 TCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAA---SLRCHAEGIPMPRITWL 375
C A+ L V VPP IR +A G+A +L C A G P+P I WL
Sbjct: 73 ECQATNEVGSTSRRAKLVVYVPPSIRE-DGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131
Query: 376 KN 377
K+
Sbjct: 132 KD 133
Score = 43.1 bits (100), Expect = 0.001
Identities = 46/204 (22%), Positives = 70/204 (34%), Gaps = 34/204 (16%)
Query: 248 SLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRN-------------GLTLNFLDL 294
S+ + R + + G S L C +G P I+W ++ G L + +
Sbjct: 96 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 155
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHA--------------SGHEQLFQTHVLQVNVP 340
E SL+ ++ G A +G EQ H P
Sbjct: 156 GGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAP 215
Query: 341 PVIRVYPESQAQE----PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
P V AQE G L+C G+P P++ W K+ V L + +G
Sbjct: 216 P--SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQ 272
Query: 397 ELHISSVRYEDTGAYTCIAKNEVG 420
L I+ D G Y C+A + G
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAG 296
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/59 (37%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
C G P P++TW K +++L GS L ++SV D+G Y C A NEVG
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVG 81
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 84.0 bits (206), Expect = 5e-16
Identities = 57/163 (34%), Positives = 72/163 (44%), Gaps = 6/163 (3%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVT+ VLTC G P + W + G L +L I + IH G
Sbjct: 3867 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVSPSGALEIGQALPIHAGR 3924
Query: 319 YTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
YTC A + HV L V PV++ P L C A GIP P ITW K
Sbjct: 3925 YTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 3984
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G++V+T +S Q + G +L I+ ED G Y CIAKN G
Sbjct: 3985 GLNVATGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAG 4024
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/192 (29%), Positives = 83/192 (43%), Gaps = 9/192 (4%)
Query: 235 LREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
+R F + QV P + + G VLTC V G P + W ++ + + +
Sbjct: 3113 VRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAV 3170
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASGHE-QLFQTHVLQVNVPPVIR---VYPESQ 350
+ G L ++++ G YTC A + + + V+ V V P IR V E
Sbjct: 3171 HGVVSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 3228
Query: 351 AQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGA 410
E G L C A+G P P + WLK+G + M L +G L + +R D GA
Sbjct: 3229 VLE-GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGA 3287
Query: 411 YTCIAKNEVGVD 422
YTC+A N G D
Sbjct: 3288 YTCVAHNPAGED 3299
Score = 73.9 bits (180), Expect = 6e-13
Identities = 55/170 (32%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL--NFLDLEDINDFGEDDSLYITKVTTIHM 316
TV G T L+C G P I W+++G L L+ ++ G LY+ +
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQE 2230
Query: 317 GNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV---AASLRCHAEGIPMP 370
G YTC S G+ Q L+V+VPP I E Q V A+L C+A G P P
Sbjct: 2231 GTYTCECSNVVGNSS--QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 2288
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW ++G V ++ QL G LH+ + TG Y+C+A+N G
Sbjct: 2289 TVTWERDGQPVGAELGLQLQ--NQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 9/192 (4%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLE-DINDFGE 302
VVQ+ E+ + + T G L C G P I W ++G ++ + + I GE
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 4092
Query: 303 DDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLR 361
L + + G YTC A + V L + V PV P ++ G LR
Sbjct: 4093 ---LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 4149
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
C A G P PRI W N V+ +S+Q GS L ++V ED+G Y C A+N VG
Sbjct: 4150 CAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGR 4205
Query: 422 DEDISSLFIEDS 433
+ +S + ++++
Sbjct: 4206 TQAVSFVHVKEA 4217
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/203 (31%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 237 EFYMAFQVVQLSLAPEDRVSVTT---VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLD 293
+F AF++ LS E R VT + L C + P + W R L+ D
Sbjct: 2738 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 2795
Query: 294 LEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQ 352
+ G L I V + G Y+C AS H L V PPVI E +
Sbjct: 2796 EVSVLQGGR--VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 2853
Query: 353 EPGVAAS----LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
E V AS L+C A G P+P I+WL+NG+ S S +L +L +G L +S+ D
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 2911
Query: 409 GAYTCIAKNEVGVDEDISSLFIE 431
+Y C+A+N+ G E + +L ++
Sbjct: 2912 ASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/188 (29%), Positives = 84/188 (44%), Gaps = 16/188 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL-----NFLDLEDINDFGEDDSLYITKVTT 313
TV+ G + VL+C V G+ + W R+ L L D+ SL I+ +
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL-------SLEISGIIP 579
Query: 314 IHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
G Y C AS + + V L V P + ++ SQ GV + C A G P P I
Sbjct: 580 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 639
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+W + + Q ++ + A G+ L I V ED G Y+C A NEVG D++ +L+ D
Sbjct: 640 SWSRESQ--ALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 696
Query: 433 SARKTLAN 440
+ N
Sbjct: 697 PPSVSAVN 704
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/160 (34%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
VG S L C V GD P I W ++GL L L G SL I + G Y C
Sbjct: 4232 VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQC 4288
Query: 322 HASGHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVD 380
A + + V+ V PV +V P+ G +LRC A G P P I WL+ G
Sbjct: 4289 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 4348
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ + S++L L +GS L + +V D G Y C+A N +G
Sbjct: 4349 L--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 4385
Score = 71.6 bits (174), Expect = 3e-12
Identities = 58/181 (32%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 242 FQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG 301
F VQ S + SV +L C G RP I W++ GL + + G
Sbjct: 3941 FLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG 4000
Query: 302 EDDSLYITKVTTIHMGNYTCHA--SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS 359
+ L I + GNY C A S + +T ++ V VPPVI + G A
Sbjct: 4001 Q---LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAF 4056
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G P P ITW K+G VS K + EL + ++ +D G YTC A+N V
Sbjct: 4057 LPCKARGSPEPNITWDKDGQPVSGAEGK--FTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 420 G 420
G
Sbjct: 4115 G 4115
Score = 70.1 bits (170), Expect = 8e-12
Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 10/183 (5%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGED 303
+V S+ ED V V G + L C V G +P + W ++G L D I+ G
Sbjct: 2441 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV- 2499
Query: 304 DSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAA---- 358
L + + G+Y+C A+ H L V + P I E A E
Sbjct: 2500 -LLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 2558
Query: 359 -SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
SL C A P P ITW+K+G + S+ + LL L I + + ED G YTC+ N
Sbjct: 2559 ISLICEALAFPSPNITWMKDGAPF--EASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 2616
Query: 418 EVG 420
E+G
Sbjct: 2617 ELG 2619
Score = 69.3 bits (168), Expect = 1e-11
Identities = 64/202 (31%), Positives = 82/202 (40%), Gaps = 12/202 (5%)
Query: 251 PEDRVSVTTVTV--GLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLY 307
P+ S TV V G L C V G P W ++G L I D SL+
Sbjct: 885 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR---ADGSLH 941
Query: 308 ITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEG 366
+ + H G Y+C A+ V L V VPP I GV ASL C A G
Sbjct: 942 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASG 1001
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
+P P ITW K + T ++ G+ L I+ +D GAY C A N VG
Sbjct: 1002 VPAPTITWTKE-TNALTSRGPHYNVSKEGT-LLIAQPSAQDAGAYVCTATNTVGFSSQEM 1059
Query: 427 SLFIEDSARKTLANILWREEGL 448
L + R L+ +W E GL
Sbjct: 1060 RLSVN---RLALSKYVWEEYGL 1078
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIN-DFGEDDS-LYITKVTTIHMGNYTC--- 321
VL C+V + P I W R+G+ L ED + F E L + ++T G+Y+C
Sbjct: 3600 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 3655
Query: 322 HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
+A+G + ++++ P IR P + A L C A+G+P P ++W K+ V +
Sbjct: 3656 NAAGSTSV--AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 3713
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+ S + +L GS L I V +D G Y C+A N G D
Sbjct: 3714 DPR-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 67.4 bits (163), Expect = 5e-11
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 14/185 (7%)
Query: 243 QVVQLSL--------APEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
++VQLS+ AP V VG VL+C P + W ++G L
Sbjct: 3019 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 3078
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASG-HEQLFQTHVLQVNVPPVI-RVYPESQAQ 352
G+ L I + G Y+C S + +T L V VPP E+ +Q
Sbjct: 3079 TQALRGGQ--RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ 3136
Query: 353 EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYT 412
G L C G+P P +TWLK+ + V + S +++ G L +S ++ G YT
Sbjct: 3137 VAGSPLVLTCDVSGVPAPTVTWLKDRMPV--ESSAVHGVVSRGGRLQLSRLQPAQAGTYT 3194
Query: 413 CIAKN 417
C+A+N
Sbjct: 3195 CVAEN 3199
Score = 67.0 bits (162), Expect = 7e-11
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 14/188 (7%)
Query: 244 VVQLSLAPEDRVSVTT----VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIND 299
VV + +AP R S V G L C G P + W ++G L +
Sbjct: 3209 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 3268
Query: 300 FGEDDSLYITKVTTIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQA---QE 353
+ + SL + + G YTC A +G + + H + V VPP I+ +
Sbjct: 3269 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPPTIKQGADGSGTLVSR 3326
Query: 354 PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC 413
PG ++ C G P ++WLK+G+ + +S++ L +G L IS V+ D G +TC
Sbjct: 3327 PGELVTMVCPVRGSPPIHVSWLKDGLPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTC 3384
Query: 414 IAKNEVGV 421
+A + GV
Sbjct: 3385 VAASPAGV 3392
Score = 63.9 bits (154), Expect = 6e-10
Identities = 55/183 (30%), Positives = 83/183 (45%), Gaps = 17/183 (9%)
Query: 246 QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNF-LDLEDINDFGEDD 304
Q++ E V+ V G++T L C G P + W+R+G + L L+ N +
Sbjct: 2257 QIAGPREPPTQVSVVQDGVAT-LECNATGKPPPTVTWERDGQPVGAELGLQLQN---QGQ 2312
Query: 305 SLYITKVTTIHMGNYTCHASG----HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS- 359
SL++ + H G Y+C A E+ F+ VL VPP + + S
Sbjct: 2313 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---VPPELIGDLDPLTNITAALHSP 2369
Query: 360 --LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
L C A GIP P I W + VS + LLA G L ++ + +D+G Y+C+A N
Sbjct: 2370 LTLLCEAMGIPPPAIRWFRGEEPVSP--GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 2427
Query: 418 EVG 420
E G
Sbjct: 2428 EAG 2430
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/134 (33%), Positives = 63/134 (47%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHA 364
L I KV G YTC A+ + V L+V VPP I P ++A + +L C A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDED 424
G+P P ++W K VS+ M +S+ +G L I + D G+Y C+A N G E
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTVSV--DGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967
Query: 425 ISSLFIEDSARKTL 438
L + R TL
Sbjct: 1968 RYGLRVNVPPRITL 1981
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 12/184 (6%)
Query: 252 EDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKV 311
E+ V TV + L C G+ P I W +NGL + + + G+ L ++
Sbjct: 2849 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTA 2906
Query: 312 TTIHMGNYTC----HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEG 366
+Y C A E+LF L+V VPP I Q + SL C
Sbjct: 2907 EVADAASYMCVAENQAGSAEKLF---TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHA 2963
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
P P +TW K+ +S + +++ LL L + R D+G YTC A N G D+ +
Sbjct: 2964 HPNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 3021
Query: 427 SLFI 430
L +
Sbjct: 3022 QLSV 3025
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 23/225 (10%)
Query: 203 VLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTT--- 259
V + DL ++ G P D R+ S+++ R V L + +VS+ T
Sbjct: 564 VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS------VWLLVREAPQVSIHTSSQ 617
Query: 260 -VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+ G+ ++C+ G P I W R L ++ G +L I V GN
Sbjct: 618 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGN 674
Query: 319 YTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y+C A+ G +Q +T L PP + G A L C A G+P PR+ W
Sbjct: 675 YSCQATNEVGTDQ--ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 732
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ G+++ ++ +L I + + D G YTC A NE+G
Sbjct: 733 RGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELG 772
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/175 (29%), Positives = 74/175 (42%), Gaps = 19/175 (10%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G + L C G +P + W R G + L + E+ SL++ V+ G+Y C
Sbjct: 1221 GENASLPCPARGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279
Query: 323 ASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAA---SLRCHAEGIPMPRITWLKN- 377
A+ L V VPP IR +A G+A +L C A G P+P I WLK+
Sbjct: 1280 ATNEVGSTSRRAKLVVYVPPSIRE-DGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 1338
Query: 378 ------------GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G D+ LL G LH ++ D+G Y+C A+N+ G
Sbjct: 1339 QLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 8/162 (4%)
Query: 265 STVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS 324
S L C G P + W + ++ ++ G L I + G+Y C AS
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVAS 1959
Query: 325 ---GHEQLFQTHVLQVNVPPVIRVYPESQAQE-PGVAASLRCHAEGIPMPRITWLKNGVD 380
G +L + L+VNVPP I + P L C+A G P P + WLK+G
Sbjct: 1960 NVAGSTEL--RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 2017
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
VS + L + G L ++S R D+G Y+C+A + VG D
Sbjct: 2018 VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/170 (28%), Positives = 72/170 (42%), Gaps = 23/170 (13%)
Query: 255 VSVTTVTVGLSTV-LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
V T TVG S+ + +V+ +W+ GL SL + +V
Sbjct: 1045 VCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL-------------PSGSLRLAQVQV 1091
Query: 314 IHMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
G+Y C AS +VL V VPP ++ P G A L C AEG P P++
Sbjct: 1092 GDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQL 1151
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+W K+GV + + + +H +++R D G Y C A N GVD
Sbjct: 1152 SWSKDGVVLQGRGPQ--------GSVHFAAIRTSDAGRYRCEASNSAGVD 1193
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/170 (27%), Positives = 71/170 (41%), Gaps = 15/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T + S L C VH P + W ++ L+ E++ +L + + G
Sbjct: 2948 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGM 3005
Query: 319 YTC---HASGHEQ-LFQTHVLQVNVPPVIRVYPESQAQ----EPGVAASLRCHAEGIPMP 370
YTC +A+G +Q L Q VL VPP R P G A L C + +P P
Sbjct: 3006 YTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 3062
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G + ++++ L G L I + D G Y+C N G
Sbjct: 3063 TVTWYKDGQPL--VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 3110
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/198 (29%), Positives = 80/198 (40%), Gaps = 19/198 (9%)
Query: 229 SDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLT 288
S + + R F + QV + L P + + V G L C G P + W ++G
Sbjct: 3388 SPAGVADRNFTLQVQVPPV-LEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEP 3446
Query: 289 LNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRV-- 345
L LE + SL + V G Y+C A + H L V PP I
Sbjct: 3447 LLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 3500
Query: 346 YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
P + PG L C A+G P P ITW K+G + L+ L N S +R
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDG--------QALTRLENNSRA-TRVLRV 3551
Query: 406 EDTGAYTCIAKNEVGVDE 423
D G YTC+A++ G E
Sbjct: 3552 RDAGLYTCLAESPAGAIE 3569
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/172 (29%), Positives = 69/172 (40%), Gaps = 11/172 (6%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R V G L C G P + W GL + + + G L +
Sbjct: 1602 RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS--VLRLESPGE 1659
Query: 314 IHMGNYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEP---GVAASLRCHAEGIP 368
G Y+C AS E + Q V +V VPP + V E Q G L C A G P
Sbjct: 1660 ASSGLYSCVASSPAGEAVLQYSV-EVQVPPQLLV-AEGLGQVTTIVGQPLELPCQASGSP 1717
Query: 369 MPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+P I WL+NG Q++ + G+ LHI V + +G + C A NE G
Sbjct: 1718 VPTIQWLQNGRPAEELAGVQVA--SQGTTLHIDHVELDHSGLFACQATNEAG 1767
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 9/168 (5%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L CA G P I W N + E +++ +L V+ G Y C A
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 328 QLFQT-HVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
Q + V PV++ S EP G + L C G P+P I W+K+G+ + +
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL--RG 4261
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 433
S L NGS L I +D G Y C+A+NE+GV + + L ++ +
Sbjct: 4262 SHLRHQLQNGS-LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSA 4308
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/184 (28%), Positives = 74/184 (40%), Gaps = 18/184 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVTV L C P I W ++G F +I L I G
Sbjct: 2552 TVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPGTHGLQILNAQKEDAGQ 2609
Query: 319 YTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGV---------AASLRCHAEGI 367
YTC + E + HV +V +PP I + E GV +L C + +
Sbjct: 2610 YTCVVTNELGEAVKNYHV-EVLIPPSIS--KDDPLGEVGVKEVKTKVNSTLTLECESWAV 2666
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISS 427
P P I W K+G V+ S +L +L G L I + D+G Y C+A N G D+ +
Sbjct: 2667 PPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 2724
Query: 428 LFIE 431
+ I+
Sbjct: 2725 VLIQ 2728
Score = 58.2 bits (139), Expect = 3e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 308 ITKVTTIHMGN---YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA----AS 359
+ ++T H+G+ Y C A S Q + L+V+ PP I + ++ E V
Sbjct: 1464 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI--WGSNETGEVAVMEDHLVQ 1521
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G+P P ITW K+G + T S ++ G +L + + D G YTC A N V
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV 1579
Query: 420 GVDEDISSL 428
G E + L
Sbjct: 1580 GAAEKATRL 1588
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 10/200 (5%)
Query: 226 DYNSDSSLTLREFYMAFQVVQLSLAPEDRVS--VTTVTVGLSTVLTCAVHGDLRPPIIWK 283
DY+ + +AF+V ++ P R V+V + +L C G P + W+
Sbjct: 3649 DYSCTARNAAGSTSVAFRV-EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWR 3707
Query: 284 RNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVP 340
++ + L+ + + SL I V G+Y C AS G ++ Q L+V P
Sbjct: 3708 KDRVPLD--PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEP 3763
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P I P + A L C A G P P + W K+G + ++ + L + L +
Sbjct: 3764 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 3823
Query: 401 SSVRYEDTGAYTCIAKNEVG 420
++ +D+ + C+ NEVG
Sbjct: 3824 TAPGPQDSAQFECVVSNEVG 3843
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/166 (25%), Positives = 70/166 (42%), Gaps = 8/166 (4%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+V S L C H P + W ++G L ++ + L + + G+
Sbjct: 2081 SVVANESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVHLSADKALLQVDRADVWDAGH 2138
Query: 319 YTCHA---SGHEQLFQTHVLQVNVPPVIRVYPE-SQAQEPGVAASLRCHAEGIPMPRITW 374
YTC A +GH + + + L V V PV + + G SL C G+P P+I+W
Sbjct: 2139 YTCEALNQAGHSE--KHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW 2196
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
K+G + + + + A G L++ + G YTC N VG
Sbjct: 2197 RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 2242
Score = 57.4 bits (137), Expect = 5e-08
Identities = 40/164 (24%), Positives = 66/164 (40%), Gaps = 3/164 (1%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T+T +L C G +P ++W ++G L+F + ++L +T
Sbjct: 3774 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 3833
Query: 319 YTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
+ C S + + + + V+VPP I L CH+ GIP P ++W K
Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
G + + S ++ L I G YTC A+N GV
Sbjct: 3894 GAQLGARGSGYR--VSPSGALEIGQALPIHAGRYTCSARNSAGV 3935
Score = 57.0 bits (136), Expect = 7e-08
Identities = 51/190 (26%), Positives = 71/190 (37%), Gaps = 10/190 (5%)
Query: 256 SVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIH 315
+V V VG VL C G P +IW R GL + + L I
Sbjct: 705 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP-----EGSSSGKLRIPAAQERD 759
Query: 316 MGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW 374
G YTC A + L V P + P E G +A L C A G P P +TW
Sbjct: 760 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 819
Query: 375 LK-NGVDVSTQMSK---QLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
+ +G + ++ S + L SV ED Y C A+N G + + L +
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 431 EDSARKTLAN 440
A +A+
Sbjct: 880 TGHAPPQIAS 889
Score = 57.0 bits (136), Expect = 7e-08
Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 3/165 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V V LTC G P ++W ++G ++ + F L + G Y
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 320 TCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG 378
+C A S + Q VLQV++PP I + + + +L C + +P P ++W K+G
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 2108
Query: 379 VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
+ + LS A+ + L + D G YTC A N+ G E
Sbjct: 2109 RPLEPRPGVHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 2151
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 16/166 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
++T G L C G +P I W ++G L L E++S + G
Sbjct: 3506 SLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGL 3556
Query: 319 YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS---LRCHAEGIPMPRITW 374
YTC A S + ++ ++V PP I V P G+A L C E P P+ITW
Sbjct: 3557 YTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW 3615
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++G+ + Q G L + ++ D+G Y+C A+N G
Sbjct: 3616 HRDGIVLQEDAHTQFP--ERGRFLQLQALSTADSGDYSCTARNAAG 3659
Score = 51.6 bits (122), Expect = 3e-06
Identities = 47/169 (27%), Positives = 72/169 (42%), Gaps = 9/169 (5%)
Query: 257 VTTVTVGLSTVLT--CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTI 314
+T +T L + LT C G P I W R ++ ED L +T+
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMTQTQEQ 2416
Query: 315 HMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQE--PGVAASLRCHAEGIPMPR 371
G Y+C AS + + ++V VPP I + + G A L C+ G P P+
Sbjct: 2417 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 2476
Query: 372 ITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G ++ + +S +G L + G Y+CIA N VG
Sbjct: 2477 LTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHYSCIAANAVG 2523
Score = 51.2 bits (121), Expect = 4e-06
Identities = 52/197 (26%), Positives = 75/197 (38%), Gaps = 31/197 (15%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPP--IIWKRNGLTLNFLDLEDINDFGEDDSLYI 308
P V V V +++ LT PP I W ++G + + GE L I
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQI 2697
Query: 309 TKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIR----------VYPESQAQEPG 355
G Y C A+ G + Q + + VPP+ + + + G
Sbjct: 2698 QPTQVSDSGRYLCVATNVAGEDD--QDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 2755
Query: 356 VA----------ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
V A L C IP P +TW + +S ++S+L G L I VR
Sbjct: 2756 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRA 2813
Query: 406 EDTGAYTCIAKNEVGVD 422
E+ G Y+C A NEVG D
Sbjct: 2814 ENAGRYSCKASNEVGED 2830
Score = 50.4 bits (119), Expect = 7e-06
Identities = 46/192 (23%), Positives = 73/192 (38%), Gaps = 23/192 (11%)
Query: 248 SLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRN-------------GLTLNFLDL 294
S+ + R + + G S L C +G P I+W ++ G L + +
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQT--HVLQVNVPPVIRVYPESQAQ 352
E SL+ ++ G Y+C A Q H+L + P V+ AQ
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA---GAAQ 1416
Query: 353 E----PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
E G L+C G+P P++ W K+ V L + +G L I+ D
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDE 1475
Query: 409 GAYTCIAKNEVG 420
G Y C+A + G
Sbjct: 1476 GRYQCVAFSPAG 1487
Score = 38.5 bits (88), Expect = 0.026
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 10/175 (5%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGH 326
+++C+VH L + +R L + + G + S I + + G Y C A
Sbjct: 445 LVSCSVHSALPFRLQLRRGEARLG--EERHFQESG-NSSWEILRASKAEEGTYECTAVSR 501
Query: 327 EQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG--VDVST 383
+ + V PP V + PG A L C G +TW+++ + ST
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 561
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTL 438
QL+ L+ L IS + D G Y C+A N GV L + ++ + ++
Sbjct: 562 GRVAQLADLS----LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 612
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 84.0 bits (206), Expect = 5e-16
Identities = 57/163 (34%), Positives = 72/163 (44%), Gaps = 6/163 (3%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVT+ VLTC G P + W + G L +L I + IH G
Sbjct: 2585 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG--YRVSPSGALEIGQALPIHAGR 2642
Query: 319 YTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
YTC A + HV L V PV++ P L C A GIP P ITW K
Sbjct: 2643 YTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKE 2702
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G++V+T +S Q + G +L I+ ED G Y CIAKN G
Sbjct: 2703 GLNVATGVSTQ---VLPGGQLRIAHASPEDAGNYLCIAKNSAG 2742
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/192 (29%), Positives = 83/192 (43%), Gaps = 9/192 (4%)
Query: 235 LREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
+R F + QV P + + G VLTC V G P + W ++ + + +
Sbjct: 1831 VRTFTLTVQVPPTFENP--KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAV 1888
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASGHE-QLFQTHVLQVNVPPVIR---VYPESQ 350
+ G L ++++ G YTC A + + + V+ V V P IR V E
Sbjct: 1889 HGVVSRG--GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 1946
Query: 351 AQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGA 410
E G L C A+G P P + WLK+G + M L +G L + +R D GA
Sbjct: 1947 VLE-GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGA 2005
Query: 411 YTCIAKNEVGVD 422
YTC+A N G D
Sbjct: 2006 YTCVAHNPAGED 2017
Score = 73.6 bits (179), Expect = 7e-13
Identities = 55/170 (32%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL--NFLDLEDINDFGEDDSLYITKVTTIHM 316
TV G T L+C G P I W+++G L L+ ++ G LY+ +
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQE 948
Query: 317 GNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV---AASLRCHAEGIPMP 370
G YTC S G+ Q L+V+VPP I E Q V A+L C+A G P P
Sbjct: 949 GTYTCECSNVVGNSS--QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPP 1006
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW ++G V ++ QL G LH+ + TG Y+C+A+N G
Sbjct: 1007 TVTWERDGQPVGAELGLQLQ--NQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 9/192 (4%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLE-DINDFGE 302
VVQ+ E+ + + T G L C G P I W ++G ++ + + I GE
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE 2810
Query: 303 DDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLR 361
L + + G YTC A + V L + V PV P ++ G LR
Sbjct: 2811 ---LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLR 2867
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
C A G P PRI W N V+ +S+Q GS L ++V ED+G Y C A+N VG
Sbjct: 2868 CAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGR 2923
Query: 422 DEDISSLFIEDS 433
+ +S + ++++
Sbjct: 2924 TQAVSFVHVKEA 2935
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/203 (31%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 237 EFYMAFQVVQLSLAPEDRVSVTT---VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLD 293
+F AF++ LS E R VT + L C + P + W R L+ D
Sbjct: 1456 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1513
Query: 294 LEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQ 352
+ G L I V + G Y+C AS H L V PPVI E +
Sbjct: 1514 EVSVLQGGR--VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1571
Query: 353 EPGVAAS----LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
E V AS L+C A G P+P I+WL+NG+ S S +L +L +G L +S+ D
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1629
Query: 409 GAYTCIAKNEVGVDEDISSLFIE 431
+Y C+A+N+ G E + +L ++
Sbjct: 1630 ASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 72.4 bits (176), Expect = 2e-12
Identities = 55/160 (34%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
VG S L C V GD P I W ++GL L L G SL I + G Y C
Sbjct: 2950 VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG---SLTIRRTERDDAGRYQC 3006
Query: 322 HASGHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVD 380
A + + V+ V PV +V P+ G +LRC A G P P I WL+ G
Sbjct: 3007 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3066
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ + S++L L +GS L + +V D G Y C+A N +G
Sbjct: 3067 L--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3103
Score = 71.6 bits (174), Expect = 3e-12
Identities = 58/181 (32%), Positives = 78/181 (43%), Gaps = 8/181 (4%)
Query: 242 FQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG 301
F VQ S + SV +L C G RP I W++ GL + + G
Sbjct: 2659 FLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG 2718
Query: 302 EDDSLYITKVTTIHMGNYTCHA--SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS 359
+ L I + GNY C A S + +T ++ V VPPVI + G A
Sbjct: 2719 Q---LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV-VQVPPVIENGLPDLSTTEGSHAF 2774
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G P P ITW K+G VS K + EL + ++ +D G YTC A+N V
Sbjct: 2775 LPCKARGSPEPNITWDKDGQPVSGAEGK--FTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 420 G 420
G
Sbjct: 2833 G 2833
Score = 70.1 bits (170), Expect = 8e-12
Identities = 56/183 (30%), Positives = 79/183 (43%), Gaps = 10/183 (5%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGED 303
+V S+ ED V V G + L C V G +P + W ++G L D I+ G
Sbjct: 1159 LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV- 1217
Query: 304 DSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAA---- 358
L + + G+Y+C A+ H L V + P I E A E
Sbjct: 1218 -LLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 1276
Query: 359 -SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
SL C A P P ITW+K+G + S+ + LL L I + + ED G YTC+ N
Sbjct: 1277 ISLICEALAFPSPNITWMKDGAPF--EASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1334
Query: 418 EVG 420
E+G
Sbjct: 1335 ELG 1337
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIN-DFGEDDS-LYITKVTTIHMGNYTC--- 321
VL C+V + P I W R+G+ L ED + F E L + ++T G+Y+C
Sbjct: 2318 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2373
Query: 322 HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
+A+G + ++++ P IR P + A L C A+G+P P ++W K+ V +
Sbjct: 2374 NAAGSTSV--AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 2431
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+ S + +L GS L I V +D G Y C+A N G D
Sbjct: 2432 DPR-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 67.4 bits (163), Expect = 5e-11
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 14/185 (7%)
Query: 243 QVVQLSL--------APEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
++VQLS+ AP V VG VL+C P + W ++G L
Sbjct: 1737 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQR 1796
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASG-HEQLFQTHVLQVNVPPVI-RVYPESQAQ 352
G+ L I + G Y+C S + +T L V VPP E+ +Q
Sbjct: 1797 TQALRGGQ--RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ 1854
Query: 353 EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYT 412
G L C G+P P +TWLK+ + V + S +++ G L +S ++ G YT
Sbjct: 1855 VAGSPLVLTCDVSGVPAPTVTWLKDRMPV--ESSAVHGVVSRGGRLQLSRLQPAQAGTYT 1912
Query: 413 CIAKN 417
C+A+N
Sbjct: 1913 CVAEN 1917
Score = 67.0 bits (162), Expect = 7e-11
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 14/188 (7%)
Query: 244 VVQLSLAPEDRVSVTT----VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDIND 299
VV + +AP R S V G L C G P + W ++G L +
Sbjct: 1927 VVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRF 1986
Query: 300 FGEDDSLYITKVTTIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQA---QE 353
+ + SL + + G YTC A +G + + H + V VPP I+ +
Sbjct: 1987 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPPTIKQGADGSGTLVSR 2044
Query: 354 PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC 413
PG ++ C G P ++WLK+G+ + +S++ L +G L IS V+ D G +TC
Sbjct: 2045 PGELVTMVCPVRGSPPIHVSWLKDGLPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTC 2102
Query: 414 IAKNEVGV 421
+A + GV
Sbjct: 2103 VAASPAGV 2110
Score = 63.9 bits (154), Expect = 6e-10
Identities = 55/183 (30%), Positives = 83/183 (45%), Gaps = 17/183 (9%)
Query: 246 QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNF-LDLEDINDFGEDD 304
Q++ E V+ V G++T L C G P + W+R+G + L L+ N +
Sbjct: 975 QIAGPREPPTQVSVVQDGVAT-LECNATGKPPPTVTWERDGQPVGAELGLQLQN---QGQ 1030
Query: 305 SLYITKVTTIHMGNYTCHASG----HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS- 359
SL++ + H G Y+C A E+ F+ VL VPP + + S
Sbjct: 1031 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---VPPELIGDLDPLTNITAALHSP 1087
Query: 360 --LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
L C A GIP P I W + VS + LLA G L ++ + +D+G Y+C+A N
Sbjct: 1088 LTLLCEAMGIPPPAIRWFRGEEPVSP--GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145
Query: 418 EVG 420
E G
Sbjct: 1146 EAG 1148
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/134 (33%), Positives = 63/134 (47%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHA 364
L I KV G YTC A+ + V L+V VPP I P ++A + +L C A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDED 424
G+P P ++W K VS+ M +S+ +G L I + D G+Y C+A N G E
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTVSV--DGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685
Query: 425 ISSLFIEDSARKTL 438
L + R TL
Sbjct: 686 RYGLRVNVPPRITL 699
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 12/184 (6%)
Query: 252 EDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKV 311
E+ V TV + L C G+ P I W +NGL + + + G+ L ++
Sbjct: 1567 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTA 1624
Query: 312 TTIHMGNYTC----HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEG 366
+Y C A E+LF L+V VPP I Q + SL C
Sbjct: 1625 EVADAASYMCVAENQAGSAEKLF---TLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHA 1681
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
P P +TW K+ +S + +++ LL L + R D+G YTC A N G D+ +
Sbjct: 1682 HPNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1739
Query: 427 SLFI 430
L +
Sbjct: 1740 QLSV 1743
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 8/162 (4%)
Query: 265 STVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS 324
S L C G P + W + ++ ++ G L I + G+Y C AS
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVAS 677
Query: 325 ---GHEQLFQTHVLQVNVPPVIRVYPESQAQE-PGVAASLRCHAEGIPMPRITWLKNGVD 380
G +L + L+VNVPP I + P L C+A G P P + WLK+G
Sbjct: 678 NVAGSTEL--RYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 735
Query: 381 VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
VS + L + G L ++S R D+G Y+C+A + VG D
Sbjct: 736 VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/170 (27%), Positives = 71/170 (41%), Gaps = 15/170 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T + S L C VH P + W ++ L+ E++ +L + + G
Sbjct: 1666 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLSDSGM 1723
Query: 319 YTC---HASGHEQ-LFQTHVLQVNVPPVIRVYPESQAQ----EPGVAASLRCHAEGIPMP 370
YTC +A+G +Q L Q VL VPP R P G A L C + +P P
Sbjct: 1724 YTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEP 1780
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G + ++++ L G L I + D G Y+C N G
Sbjct: 1781 TVTWYKDGQPL--VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1828
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/198 (29%), Positives = 80/198 (40%), Gaps = 19/198 (9%)
Query: 229 SDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLT 288
S + + R F + QV + L P + + V G L C G P + W ++G
Sbjct: 2106 SPAGVADRNFTLQVQVPPV-LEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEP 2164
Query: 289 LNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRV-- 345
L LE + SL + V G Y+C A + H L V PP I
Sbjct: 2165 LLSQSLE------QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2218
Query: 346 YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
P + PG L C A+G P P ITW K+G + L+ L N S +R
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDG--------QALTRLENNSRA-TRVLRV 2269
Query: 406 EDTGAYTCIAKNEVGVDE 423
D G YTC+A++ G E
Sbjct: 2270 RDAGLYTCLAESPAGAIE 2287
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/172 (29%), Positives = 69/172 (40%), Gaps = 11/172 (6%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R V G L C G P + W GL + + + G L +
Sbjct: 320 RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS--VLRLESPGE 377
Query: 314 IHMGNYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEP---GVAASLRCHAEGIP 368
G Y+C AS E + Q V +V VPP + V E Q G L C A G P
Sbjct: 378 ASSGLYSCVASSPAGEAVLQYSV-EVQVPPQLLV-AEGLGQVTTIVGQPLELPCQASGSP 435
Query: 369 MPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+P I WL+NG Q++ + G+ LHI V + +G + C A NE G
Sbjct: 436 VPTIQWLQNGRPAEELAGVQVA--SQGTTLHIDHVELDHSGLFACQATNEAG 485
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/184 (28%), Positives = 74/184 (40%), Gaps = 18/184 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
TVTV L C P I W ++G F +I L I G
Sbjct: 1270 TVTVNNPISLICEALAFPSPNITWMKDGAP--FEASRNIQLLPGTHGLQILNAQKEDAGQ 1327
Query: 319 YTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGV---------AASLRCHAEGI 367
YTC + E + HV +V +PP I + E GV +L C + +
Sbjct: 1328 YTCVVTNELGEAVKNYHV-EVLIPPSIS--KDDPLAEVGVKEVKTKVNSTLTLECESWAV 1384
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISS 427
P P I W K+G V+ S +L +L G L I + D+G Y C+A N G D+ +
Sbjct: 1385 PPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFN 1442
Query: 428 LFIE 431
+ I+
Sbjct: 1443 VLIQ 1446
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 9/168 (5%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L CA G P I W N + E +++ +L V+ G Y C A
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 328 QLFQT-HVLQVNVPPVIRVYPESQAQEP-GVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
Q + V PV++ S EP G + L C G P+P I W+K+G+ + +
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL--RG 2979
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 433
S L NGS L I +D G Y C+A+NE+GV + + L ++ +
Sbjct: 2980 SHLRHQLQNGS-LTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSA 3026
Score = 58.2 bits (139), Expect = 3e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 308 ITKVTTIHMGN---YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVA----AS 359
+ ++T H+G+ Y C A S Q + L+V+ PP I + ++ E V
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI--WGSNETGEVAVMEDHLVQ 239
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L C A G+P P ITW K+G + T S ++ G +L + + D G YTC A N V
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV 297
Query: 420 GVDEDISSL 428
G E + L
Sbjct: 298 GAAEKATRL 306
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 10/200 (5%)
Query: 226 DYNSDSSLTLREFYMAFQVVQLSLAPEDRVS--VTTVTVGLSTVLTCAVHGDLRPPIIWK 283
DY+ + +AF+V ++ P R V+V + +L C G P + W+
Sbjct: 2367 DYSCTARNAAGSTSVAFRV-EIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWR 2425
Query: 284 RNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVP 340
++ + L+ + + SL I V G+Y C AS G ++ Q L+V P
Sbjct: 2426 KDRVPLD--PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEP 2481
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P I P + A L C A G P P + W K+G + ++ + L + L +
Sbjct: 2482 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 2541
Query: 401 SSVRYEDTGAYTCIAKNEVG 420
++ +D+ + C+ NEVG
Sbjct: 2542 TAPGPQDSAQFECVVSNEVG 2561
Score = 57.4 bits (137), Expect = 5e-08
Identities = 40/164 (24%), Positives = 66/164 (40%), Gaps = 3/164 (1%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T+T +L C G +P ++W ++G L+F + ++L +T
Sbjct: 2492 TLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQ 2551
Query: 319 YTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
+ C S + + + + V+VPP I L CH+ GIP P ++W K
Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
G + + S ++ L I G YTC A+N GV
Sbjct: 2612 GAQLGARGSGYR--VSPSGALEIGQALPIHAGRYTCSARNSAGV 2653
Score = 57.0 bits (136), Expect = 7e-08
Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 3/165 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V V LTC G P ++W ++G ++ + F L + G Y
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 320 TCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG 378
+C A S + Q VLQV++PP I + + + +L C + +P P ++W K+G
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 826
Query: 379 VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
+ + LS A+ + L + D G YTC A N+ G E
Sbjct: 827 RPLEPRPGVHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 869
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 8/166 (4%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+V S L C H P + W ++G L ++ + L + + G+
Sbjct: 799 SVVANESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVHLSADKALLQVDRADVWDAGH 856
Query: 319 YTCHA---SGHEQLFQTHVLQVNVPPVIRVYPE-SQAQEPGVAASLRCHAEGIPMPRITW 374
YTC A +GH + + + L V V PV + + G L C G+P P+I+W
Sbjct: 857 YTCEALNQAGHSE--KHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW 914
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
K+G + + + + A G L++ + G YTC N VG
Sbjct: 915 RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 960
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/166 (27%), Positives = 71/166 (42%), Gaps = 16/166 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
++T G L C G +P I W ++G L L E++S + G
Sbjct: 2224 SLTPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGL 2274
Query: 319 YTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS---LRCHAEGIPMPRITW 374
YTC A S + ++ ++V PP I V P G+A L C E P P+ITW
Sbjct: 2275 YTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITW 2333
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++G+ + Q G L + ++ D+G Y+C A+N G
Sbjct: 2334 HRDGIVLQEDAHTQFP--ERGRFLQLQALSTADSGDYSCTARNAAG 2377
Score = 52.0 bits (123), Expect = 2e-06
Identities = 48/196 (24%), Positives = 75/196 (38%), Gaps = 23/196 (11%)
Query: 244 VVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRN-------------GLTLN 290
VV S+ + R + + G S L C +G P I+W ++ G L
Sbjct: 14 VVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLG 73
Query: 291 FLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQT--HVLQVNVPPVIRVYPE 348
+ + E SL+ ++ G Y+C A Q H+L + P V+
Sbjct: 74 WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA--- 130
Query: 349 SQAQE----PGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVR 404
AQE G L+C G+P P++ W K+ V L + +G L I+
Sbjct: 131 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSH 189
Query: 405 YEDTGAYTCIAKNEVG 420
D G Y C+A + G
Sbjct: 190 VGDEGRYQCVAFSPAG 205
Score = 51.6 bits (122), Expect = 3e-06
Identities = 47/169 (27%), Positives = 72/169 (42%), Gaps = 9/169 (5%)
Query: 257 VTTVTVGLSTVLT--CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTI 314
+T +T L + LT C G P I W R ++ ED L +T+
Sbjct: 1077 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMTQTQEQ 1134
Query: 315 HMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQE--PGVAASLRCHAEGIPMPR 371
G Y+C AS + + ++V VPP I + + G A L C+ G P P+
Sbjct: 1135 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194
Query: 372 ITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+TW K+G ++ + +S +G L + G Y+CIA N VG
Sbjct: 1195 LTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHYSCIAANAVG 1241
Score = 50.8 bits (120), Expect = 5e-06
Identities = 52/197 (26%), Positives = 75/197 (38%), Gaps = 31/197 (15%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPP--IIWKRNGLTLNFLDLEDINDFGEDDSLYI 308
P V V V +++ LT PP I W ++G + + GE L I
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQI 1415
Query: 309 TKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIR----------VYPESQAQEPG 355
G Y C A+ G + Q + + VPP+ + + + G
Sbjct: 1416 QPTQVSDSGRYLCVATNVAGEDD--QDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1473
Query: 356 VA----------ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
V A L C IP P +TW + +S ++S+L G L I VR
Sbjct: 1474 VTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSA--GDEVSVLQGGRVLQIPLVRA 1531
Query: 406 EDTGAYTCIAKNEVGVD 422
E+ G Y+C A NEVG D
Sbjct: 1532 ENAGRYSCKASNEVGED 1548
Score = 46.6 bits (109), Expect = 1e-04
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 20/112 (17%)
Query: 325 GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA---SLRCHAEGIPMPRITWLKN---- 377
G E L T + VPP IR +A G+A +L C A G P+P I WLK+
Sbjct: 4 GKEPLLNTGSV---VPPSIRE-DGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 59
Query: 378 ---------GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G D+ LL G LH ++ D+G Y+C A+N+ G
Sbjct: 60 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 111
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 79.3 bits (194), Expect = 1e-14
Identities = 65/208 (31%), Positives = 93/208 (44%), Gaps = 23/208 (11%)
Query: 241 AFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF 300
A++ + + PE+ T+TV + VL C G+ RP + W R L + +E I
Sbjct: 234 AYKEPAILVGPEN----LTLTVHQTAVLECVATGNPRPIVSWSR--LDGRPIGVEGIQVL 287
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV---LQVNVPPVIRVYPESQAQEPGVA 357
G + L I+ VT H G Y C A+ + L V P +P+S ++ G
Sbjct: 288 GTGN-LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTT 346
Query: 358 ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
A C A+G P P +TWLKNG + + L N S L IS + ED Y C+A+N
Sbjct: 347 AMFTCQAQGEPPPHVTWLKNGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
Query: 418 EVGVDEDISSLFIEDSARKTLANILWRE 445
G + SAR T +LW E
Sbjct: 405 SAGSS--------QASARLT---VLWAE 421
Score = 65.9 bits (159), Expect = 2e-10
Identities = 61/215 (28%), Positives = 95/215 (44%), Gaps = 27/215 (12%)
Query: 248 SLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLY 307
++ P D V+V G VL C V G I W++NG+ L + G SL
Sbjct: 45 AVEPSDDVAVP----GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANG---SLM 97
Query: 308 ITKV------TTIHMGNYTCHASGHEQLFQTHVLQVNVPPV--IRVYPESQAQEPGVAAS 359
I + G+Y C A L + ++ + V+P++ E G A
Sbjct: 98 IRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
+C G+P P ITW KN V + T +++ +LL G L I+ +R ED G + C+A N
Sbjct: 158 FQCQIHGLPKPLITWEKNRVPIDTD-NERYTLLPKG-VLQITGLRAEDGGIFHCVASN-- 213
Query: 420 GVDEDISSLFIEDSARKTLANI---LWREEGLSVG 451
I+S+ I AR T++ ++E + VG
Sbjct: 214 -----IASIRISHGARLTVSGSGSGAYKEPAILVG 243
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 77.8 bits (190), Expect = 4e-14
Identities = 56/187 (29%), Positives = 81/187 (43%), Gaps = 12/187 (6%)
Query: 249 LAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYI 308
+ P+D T V +G ST L C G P I W R+ N L+L+ LY+
Sbjct: 334 IQPQD----TEVLIGTSTTLECMATGHPHPLITWTRD----NGLELDGSRHVATSSGLYL 385
Query: 309 TKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGI 367
+T G +TCHA+ Q + V PP V P+ Q A C A+G
Sbjct: 386 QNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISS 427
P P I W K G + + Q ++L++G+ L I D G Y C A + +GV +
Sbjct: 446 PPPVIVWTKTGGQLPVE--GQHTVLSSGT-LRIDRAAQHDQGQYECQAVSSLGVKKVSVQ 502
Query: 428 LFIEDSA 434
L ++ A
Sbjct: 503 LTVKPKA 509
Score = 71.2 bits (173), Expect = 4e-12
Identities = 56/207 (27%), Positives = 95/207 (45%), Gaps = 18/207 (8%)
Query: 231 SSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLN 290
+S+T+ EF Q +++ P+D V G + TC G+ +P IIW N +L+
Sbjct: 222 ASVTVEEFNC--QSPRITFEPQD----VEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLD 275
Query: 291 FLDLEDINDFGEDDSLYITKVTTIHMGNYTCHA--SGHEQLFQTHVLQVN---VPPVIRV 345
D +N F +D +L I G Y C A S E Q+ +L+ + P +
Sbjct: 276 LEDDTRLNVF-DDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVI 334
Query: 346 YPESQAQEPGVAASLRCHAEGIPMPRITWLK-NGVDVSTQMSKQLSLLANGSELHISSVR 404
P+ G + +L C A G P P ITW + NG+++ +A S L++ ++
Sbjct: 335 QPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH-----VATSSGLYLQNIT 389
Query: 405 YEDTGAYTCIAKNEVGVDEDISSLFIE 431
D G +TC A N G + +++ ++
Sbjct: 390 QRDHGRFTCHANNSHGTVQAAANIIVQ 416
Score = 63.5 bits (153), Expect = 8e-10
Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 15/192 (7%)
Query: 246 QLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS 305
Q ++ P+D+V + V C G+ P I+W + G L +E + +
Sbjct: 420 QFTVTPKDQVVLEEHAVEW----LCEADGNPPPVIVWTKTG---GQLPVEGQHTVLSSGT 472
Query: 306 LYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVY---PESQAQEPGVAASLRC 362
L I + G Y C A + + V P + V+ P+ + E G ++ C
Sbjct: 473 LRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISC 532
Query: 363 HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
HA+G P P ITW K GV ++ + + L I + D G Y C+A+N G+
Sbjct: 533 HAQGEPQPIITWNKEGVQITESGKFHVD---DEGTLTIYDAGFPDQGRYECVARNSFGL- 588
Query: 423 EDISSLFIEDSA 434
++++F+ +A
Sbjct: 589 -AVTNMFLTVTA 599
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 77.4 bits (189), Expect = 5e-14
Identities = 57/169 (33%), Positives = 80/169 (47%), Gaps = 8/169 (4%)
Query: 261 TVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
++G + C V GDL I W+++G + I++ SL I+ ++ +H GNY
Sbjct: 608 SIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNY 667
Query: 320 TCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW-LKN 377
TC A + L V VPP V P Q G A L C AEG P+P I W
Sbjct: 668 TCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSK 727
Query: 378 GVDV----STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
G V ++ ++ +L+NGS L I V ED+G Y C N+VG D
Sbjct: 728 GAGVPQFQPIALNGRIQVLSNGS-LLIKHVVEEDSGYYLCKVSNDVGAD 775
Score = 61.2 bits (147), Expect = 4e-09
Identities = 53/175 (30%), Positives = 79/175 (45%), Gaps = 22/175 (12%)
Query: 261 TVGLSTVLTCAVHGDLRPPIIWKRNGLTLN---FLDLEDINDFGEDDSLYITKVTTIHMG 317
+VG L+C+V G + W RNG LN + + IN ++L + + G
Sbjct: 326 SVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH----ENLIMDHMVKSDGG 381
Query: 318 NYTCHASGHEQLFQTHV---LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW 374
Y C + Q +V L+ P +I + E + P SL C+ +G P+P ITW
Sbjct: 382 AYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSE-KVVSPAEPVSLMCNVKGTPLPTITW 440
Query: 375 -------LKNGVDVSTQMSKQLSLLAN-GSELHISSVRYEDTGAYTCIAKNEVGV 421
LK G S ++S+ ++ N S L+ISS + D G Y C A N GV
Sbjct: 441 TLDDDPILKGG---SHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
Score = 52.4 bits (124), Expect = 2e-06
Identities = 50/176 (28%), Positives = 74/176 (42%), Gaps = 7/176 (3%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT-IHMG 317
T G T + C V G I W +N L F + F + +L ++ V + G
Sbjct: 514 TAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVA--FENNGTLKLSDVQKEVDEG 571
Query: 318 NYTCHASGHEQLF--QTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMP-RITW 374
YTC+ QL Q+ + V VPP I+ + E G + C +P ITW
Sbjct: 572 EYTCNVLVQPQLSTSQSVHVTVKVPPFIQPF-EFPRFSIGQRVFIPCVVVSGDLPITITW 630
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
K+G + + + + S L IS++ G YTCIA+NE E S L +
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/181 (24%), Positives = 74/181 (40%), Gaps = 11/181 (6%)
Query: 263 GLSTVLTCAVHGDLRPPIIWK--RNGLTLNF--LDLEDINDFGEDDSLYITKVTTIHMGN 318
G + +L C+ G P I+WK + F + L + SL I V G
Sbjct: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
Query: 319 YTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C S + ++ L V +P +I YP + G + C A G + W K
Sbjct: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRY-----EDTGAYTCIAKNEVGVDEDISSLFIE 431
++ +M++ L E IS+++ ED+G ++C A N G D I L ++
Sbjct: 824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
Query: 432 D 432
+
Sbjct: 884 E 884
Score = 51.6 bits (122), Expect = 3e-06
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 360 LRCHAEGIPMPRITWLK--NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
L C A G P P + W+K NG + + S+ +NGS + I +V+ ED+G Y+CIA N
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSCIANN 1363
Query: 418 EVGVDEDISSLFIE---DSARKTLA 439
G DE I +L ++ D R T++
Sbjct: 1364 NWGSDEIILNLQVQVPPDQPRLTVS 1388
Score = 48.5 bits (114), Expect = 3e-05
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 6/143 (4%)
Query: 297 INDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGV 356
I D +D LY + T H S +LF + + P ++ + +A G
Sbjct: 183 IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPAN-SAPSILDGFDHRKAMA-GQ 240
Query: 357 AASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAK 416
L C A G P P WLK+ + + ++S + G L I ++R D+G+Y C
Sbjct: 241 RVELPCKALGHPEPDYRWLKDNMPL--ELSGRFQKTVTG--LLIENIRPSDSGSYVCEVS 296
Query: 417 NEVGVDEDISSLFIEDSARKTLA 439
N G + I L+++ + T++
Sbjct: 297 NRYGTAKVIGRLYVKQPLKATIS 319
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/178 (20%), Positives = 63/178 (35%), Gaps = 6/178 (3%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G L C G P W ++ + L G L I + G+Y C
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCE 294
Query: 323 ASGHEQLFQT-HVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
S + L V P + P G SL C G ++W +NG +
Sbjct: 295 VSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEIL 354
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLA 439
+ + +++ + N L + + D GAY C + + +D + +ED K ++
Sbjct: 355 NPGKNVRITGI-NHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIIS 411
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 75.9 bits (185), Expect = 1e-13
Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 10/196 (5%)
Query: 242 FQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG 301
+ +VQ+ + S TV G + L C +G P I W+ LT + E G
Sbjct: 125 YLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH--LTPTGREFE-----G 177
Query: 302 EDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQV--NVPPVIRVYPESQAQEPGVAAS 359
E++ L I +T G Y C A+ ++V N PP I ++A G AS
Sbjct: 178 EEEYLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATT-GRQAS 236
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L+C A +P P W ++ +++ ++ S L +++V E G YTC+A N++
Sbjct: 237 LKCEASAVPAPDFEWYRDDTRINSANGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKL 296
Query: 420 GVDEDISSLFIEDSAR 435
GV LF S R
Sbjct: 297 GVTNASLVLFRPGSVR 312
Score = 48.5 bits (114), Expect = 3e-05
Identities = 50/170 (29%), Positives = 65/170 (38%), Gaps = 17/170 (10%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIW-KRNGLTLNFLDLEDINDFGE-------DDSLYITK 310
TV G + +L C V D + W R+G+ D ++ E + SL I K
Sbjct: 42 TVRQGDTAILRCVVE-DKNSKVAWLNRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQK 100
Query: 311 VTTIHMGNYTCHA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
V G+YTC + HE L V VPP I G +L C A G P
Sbjct: 101 VDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNISSDVTVNEGSNVTLVCMANGRPE 160
Query: 370 PRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
P ITW T ++ L I + E +G Y C A NEV
Sbjct: 161 PVITWRH-----LTPTGREFE--GEEEYLEILGITREQSGKYECKAANEV 203
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 321 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 494
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 495 SG--EATWSAYIE 505
Score = 66.6 bits (161), Expect = 9e-11
Identities = 55/177 (31%), Positives = 76/177 (42%), Gaps = 15/177 (8%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 228 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 283
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
MG+YTC A G + T +QV + PP V P Q G + +C A G P
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343
Query: 370 PRITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 10/175 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 198
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ++ K + + L I V D G+YTC+A+N VG E ++L ++
Sbjct: 259 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 63/184 (34%), Gaps = 32/184 (17%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDF 300
V+ G L C G P I W + G +L FL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
D+ +Y+ NY A H + +L+ + R P G A +
Sbjct: 100 RPDEGVYVCVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVM 150
Query: 361 RCH-AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P P I+W K+G S K + G +L I+ R D G Y C+ N V
Sbjct: 151 ECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 420 GVDE 423
G E
Sbjct: 208 GERE 211
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 321 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 494
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 495 SG--EATWSAYIE 505
Score = 66.6 bits (161), Expect = 9e-11
Identities = 55/177 (31%), Positives = 76/177 (42%), Gaps = 15/177 (8%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 228 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 283
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
MG+YTC A G + T +QV + PP V P Q G + +C A G P
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343
Query: 370 PRITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 10/175 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 198
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ++ K + + L I V D G+YTC+A+N VG E ++L ++
Sbjct: 259 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 63/184 (34%), Gaps = 32/184 (17%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDF 300
V+ G L C G P I W + G +L FL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
D+ +Y+ NY A H + +L+ + R P G A +
Sbjct: 100 RPDEGVYVCVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVM 150
Query: 361 RCH-AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P P I+W K+G S K + G +L I+ R D G Y C+ N V
Sbjct: 151 ECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 420 GVDE 423
G E
Sbjct: 208 GERE 211
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 318 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 373
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 491
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 492 SG--EATWSAYIE 502
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/176 (31%), Positives = 74/176 (42%), Gaps = 16/176 (9%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 228 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 283
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMP 370
MG+YTC A G + T L V PP V P Q G + +C A G P P
Sbjct: 284 GDMGSYTCVAENMVGKAEASAT--LTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQP 341
Query: 371 RITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 342 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 396
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 10/176 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 198
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+ ++ K + + L I V D G+YTC+A+N VG E ++L +++
Sbjct: 259 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 63/184 (34%), Gaps = 32/184 (17%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDF 300
V+ G L C G P I W + G +L FL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
D+ +Y+ NY A H + +L+ + R P G A +
Sbjct: 100 RPDEGVYVCVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVM 150
Query: 361 RCH-AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P P I+W K+G S K + G +L I+ R D G Y C+ N V
Sbjct: 151 ECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 420 GVDE 423
G E
Sbjct: 208 GERE 211
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 321 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 494
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 495 SG--EATWSAYIE 505
Score = 66.6 bits (161), Expect = 9e-11
Identities = 55/177 (31%), Positives = 76/177 (42%), Gaps = 15/177 (8%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 228 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 283
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
MG+YTC A G + T +QV + PP V P Q G + +C A G P
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343
Query: 370 PRITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 10/175 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 198
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ++ K + + L I V D G+YTC+A+N VG E ++L ++
Sbjct: 259 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 63/184 (34%), Gaps = 32/184 (17%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDF 300
V+ G L C G P I W + G +L FL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
D+ +Y+ NY A H + +L+ + R P G A +
Sbjct: 100 RPDEGVYVCVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVM 150
Query: 361 RCH-AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P P I+W K+G S K + G +L I+ R D G Y C+ N V
Sbjct: 151 ECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 420 GVDE 423
G E
Sbjct: 208 GERE 211
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 321 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 437 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 494
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 495 SG--EATWSAYIE 505
Score = 66.6 bits (161), Expect = 9e-11
Identities = 55/177 (31%), Positives = 76/177 (42%), Gaps = 15/177 (8%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 228 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 283
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQV-NVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
MG+YTC A G + T +QV + PP V P Q G + +C A G P
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343
Query: 370 PRITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
P I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 10/175 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 198
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ++ K + + L I V D G+YTC+A+N VG E ++L ++
Sbjct: 259 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/184 (24%), Positives = 63/184 (34%), Gaps = 32/184 (17%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDF 300
V+ G L C G P I W + G +L FL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL 360
D+ +Y+ NY A H + +L+ + R P G A +
Sbjct: 100 RPDEGVYVCVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVM 150
Query: 361 RCH-AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P P I+W K+G S K + G +L I+ R D G Y C+ N V
Sbjct: 151 ECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 420 GVDE 423
G E
Sbjct: 208 GERE 211
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/193 (33%), Positives = 85/193 (44%), Gaps = 20/193 (10%)
Query: 251 PEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG---LTLNFLDLEDINDFG--EDDS 305
P D+V V +G + C G+ +P I W+R G L ++ + + F +
Sbjct: 357 PRDQV----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412
Query: 306 LYITKVTTIHMGNYTCHASG-------HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
L IT V +G Y C L T V+ PPVIR P +Q
Sbjct: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C A G P+P I W K+GV VSTQ S+ + L NG L I + DTG YTCIA
Sbjct: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSR-IKQLENG-VLQIRYAKLGDTGRYTCIASTP 530
Query: 419 VGVDEDISSLFIE 431
G E S +IE
Sbjct: 531 SG--EATWSAYIE 541
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/176 (31%), Positives = 74/176 (42%), Gaps = 16/176 (9%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R S VTV S C GD P + W+++ L + + +D +L I KVT
Sbjct: 267 RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTA 322
Query: 314 IHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMP 370
MG+YTC A G + T L V PP V P Q G + +C A G P P
Sbjct: 323 GDMGSYTCVAENMVGKAEASAT--LTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQP 380
Query: 371 RITWLKNGVD------VSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
I W + G Q S + S+ G +L I++V+ D G Y C N G
Sbjct: 381 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 435
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 10/176 (5%)
Query: 260 VTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
V VG V+ C G P I WK++G L+ D E I G L IT G
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYTRKSDAGK 237
Query: 319 YTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C + ++ V ++ V P P + A +A +C A G P+P + W K
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+ ++ K + + L I V D G+YTC+A+N VG E ++L +++
Sbjct: 298 D----DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/92 (35%), Positives = 41/92 (44%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS---LL 392
Q + PP I +P G A+L C AEG P P I W K G V T S LL
Sbjct: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Query: 393 ANGSELHISSVR----YEDTGAYTCIAKNEVG 420
+GS + V D G Y C+A+N +G
Sbjct: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 154
Score = 43.9 bits (102), Expect = 6e-04
Identities = 57/236 (24%), Positives = 82/236 (34%), Gaps = 46/236 (19%)
Query: 218 PGDLLRFDDY--------NSDSSLTLREFYMAFQVVQLSLAPE--DRVSVTTVTVGLSTV 267
P D+ R +D+ N D+SL Y ++ Q P + S V+ G
Sbjct: 31 PEDVERGNDHGTPIPTSDNDDNSLG----YTGSRLRQEDFPPRIVEHPSDLIVSKGEPAT 86
Query: 268 LTCAVHGDLRPPIIWKRNGL-------------------TLNFLDLEDINDFGEDDSLYI 308
L C G P I W + G +L FL + D+ +Y+
Sbjct: 87 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 146
Query: 309 TKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCH-AEGI 367
NY A H + +L+ + R P G A + C G
Sbjct: 147 CVAR-----NYLGEAVSHNASLEVAILRDD----FRQNPSDVMVAVGEPAVMECQPPRGH 197
Query: 368 PMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
P P I+W K+G S K + G +L I+ R D G Y C+ N VG E
Sbjct: 198 PEPTISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 250
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 73.9 bits (180), Expect = 6e-13
Identities = 53/185 (28%), Positives = 77/185 (41%), Gaps = 6/185 (3%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
T V VG S L C+ G P I W R T L ++ + LYI V G
Sbjct: 351 TEVLVGESVTLECSATGHPPPRISWTRGDRTP--LPVDPRVNITPSGGLYIQNVVQGDSG 408
Query: 318 NYTCHASGH-EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
Y C A+ + + + T + V P V P+ + G +C A+G P P I W K
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK 468
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARK 436
G +S + L+ + L IS V D G Y C A N +G + ++ L ++
Sbjct: 469 GGSQLSVD---RRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP 525
Query: 437 TLANI 441
A+I
Sbjct: 526 VFASI 530
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 13/196 (6%)
Query: 228 NSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGL 287
N+ S+ F + + Q ++ P+DRV + TV C G+ P I W + G
Sbjct: 416 NNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQ----CEAKGNPPPVIAWTKGGS 471
Query: 288 TLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIR 344
L+ + G +L I+ V G Y C A G +++ +Q V PV
Sbjct: 472 QLSVDRRHLVLSSG---TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA 528
Query: 345 VYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVR 404
P E G L C ++G P P ITW K+GV V+ S + + G L I+ V
Sbjct: 529 SIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE--SGKFHISPEGF-LTINDVG 585
Query: 405 YEDTGAYTCIAKNEVG 420
D G Y C+A+N +G
Sbjct: 586 PADAGRYECVARNTIG 601
Score = 62.4 bits (150), Expect = 2e-09
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 8/165 (4%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
VT G + TC G+ +P IIW RN L+ +N +D +L I G Y
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL-DDGTLMIQNTQETDQGIY 315
Query: 320 TCHASGHEQLFQTHVLQVN-----VPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW 374
C A +T + + P + P++ G + +L C A G P PRI+W
Sbjct: 316 QCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISW 375
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
+ G + ++++ +G L+I +V D+G Y C A N +
Sbjct: 376 TR-GDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI 418
Score = 53.5 bits (127), Expect = 8e-07
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P I P+ G C AEG P P I WL+N ++S + +L+LL +G+ L I
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMI 304
Query: 401 SSVRYEDTGAYTCIAKNEVG--VDEDISSLFIEDSARKT 437
+ + D G Y C+AKN G ++++ + AR T
Sbjct: 305 QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPT 343
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 73.9 bits (180), Expect = 6e-13
Identities = 56/168 (33%), Positives = 83/168 (49%), Gaps = 13/168 (7%)
Query: 270 CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS--LYITKVTTIHMGNYTCHAS-GH 326
C+ G +P I W+R D + ++ D++ L+ +VT GNYTC AS G
Sbjct: 524 CSATGREKPTIKWER-------ADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGP 576
Query: 327 EQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL-KNGVDVSTQ 384
+ + HV L V V +V PE G A L+C A+G P P I W K+ + T+
Sbjct: 577 QGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK 636
Query: 385 MSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+ ++ + NGS L I V ED+G YTCIA N + + L++ D
Sbjct: 637 LGPRMHIFQNGS-LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD 683
Score = 47.4 bits (111), Expect = 6e-05
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 14/167 (8%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIH-MGNYTC 321
G +L C V + W +G + D E F + SL V + G + C
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQ--DTE--RRFAQGSSLSFAAVDRLQDSGTFQC 101
Query: 322 HA----SGHEQLFQT---HVLQVNVPPVIRVYPESQAQ-EPGVAASLRCHAEGIPMPRIT 373
A +G E ++ + PV+ +P S+A+ +P +LRCH +G P P
Sbjct: 102 VARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ 161
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
W ++G +S S ++ + L + E +G Y+C A + G
Sbjct: 162 WFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/163 (23%), Positives = 67/163 (41%), Gaps = 11/163 (6%)
Query: 261 TVGLSTVLTCAVHGDL-RPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
T G +TC L P + W+ G+ L + + L + + G Y
Sbjct: 334 TAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG----RVYQKGHELVLANIAESDAGVY 389
Query: 320 TCHASG--HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
TCHA+ ++ ++ VP ++ +SQ +E G L C + P P + W +N
Sbjct: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEE-GKPGYLDCLTQATPKPTVVWYRN 448
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ +S + + NG+ L I+SV D Y C++ G
Sbjct: 449 QMLISE--DSRFEVFKNGT-LRINSVEVYDGTWYRCMSSTPAG 488
Score = 42.0 bits (97), Expect = 0.002
Identities = 40/154 (25%), Positives = 62/154 (40%), Gaps = 14/154 (9%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDIN-DFGEDDSLYITKVTTIHMGNYTCHASGH 326
L C +P ++W RN + ++ ED + ++ +L I V Y C +S
Sbjct: 431 LDCLTQATPKPTVVWYRNQMLIS----EDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTP 486
Query: 327 EQLFQTHVLQVNVPPVIRVYPESQAQ---EPGVAASLRCHAEGIPMPRITWLKNGVDVST 383
+ +V V ++ P Q Q E A++ C A G P I W + +
Sbjct: 487 AGSIEAQA-RVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWER-----AD 540
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
S + N LH + V +D G YTCIA N
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 574
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/151 (25%), Positives = 58/151 (38%), Gaps = 39/151 (25%)
Query: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSV-RY 405
P SQ G A LRC E + WL +G V + A GS L ++V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVI 465
+D+G + C+A+++V +E S+ NI W E G +++
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG-------------PVVLK 132
Query: 466 HPVD-------------CEIQRHLKPTEKIF 483
HP C I H +PT + F
Sbjct: 133 HPASEAEIQPQTQVTLRCHIDGHPRPTYQWF 163
Score = 36.6 bits (83), Expect = 0.100
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 14/122 (11%)
Query: 305 SLYITKVTTIHMGNYTCHASGHEQ----LFQT-HVLQVNVPPVIRVYPESQAQEPGVAAS 359
SL +T+V + G Y C G L T H+ ++ P+ E + G
Sbjct: 285 SLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLF----EPRVFTAGSEER 340
Query: 360 LRC-HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
+ C +G+P P + W GV + T + G EL ++++ D G YTC A N
Sbjct: 341 VTCLPPKGLPEPSVWWEHAGVRLPTHGR----VYQKGHELVLANIAESDAGVYTCHAANL 396
Query: 419 VG 420
G
Sbjct: 397 AG 398
Score = 35.0 bits (79), Expect = 0.29
Identities = 23/66 (34%), Positives = 29/66 (43%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
TTV G + +L C GD +P I WK L+ L ++ SL I V G
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
Query: 318 NYTCHA 323
YTC A
Sbjct: 661 RYTCIA 666
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/212 (26%), Positives = 93/212 (43%), Gaps = 10/212 (4%)
Query: 229 SDSSLTLREFYMAFQVVQLSLAPEDRVSVTTV--TVGLSTVLTCAVHGDLRPPIIWKRNG 286
+++S+ F++ + L P + + TVGL LTC ++G + W R+G
Sbjct: 6153 AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDG 6212
Query: 287 LTLNFLDLEDINDFGEDD--SLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVP--- 340
+ L D E++ D+ +L I + H G Y+C AS + L P
Sbjct: 6213 VLLR--DDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKS 6270
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P + P S G +A CH G RITW K+ ++ + ++ + N L I
Sbjct: 6271 PFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRI 6330
Query: 401 SSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
V D+G YTC A N+VG D + L +++
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSVKE 6362
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/201 (27%), Positives = 80/201 (39%), Gaps = 15/201 (7%)
Query: 261 TVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYT 320
TVGL V CA+ G + W ++G L + +L I K G Y+
Sbjct: 8069 TVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 321 C-------HASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
C AS +L T + PP + G +A CH G +++
Sbjct: 8129 CTATNPIGSASSSARLILT---EGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS 8185
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE-----DISSL 428
W K+ ++ + Q+S L N + L + V D+G YTC A NEVG D +I
Sbjct: 8186 WAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKER 8245
Query: 429 FIEDSARKTLANILWREEGLS 449
I S K L+ + EG S
Sbjct: 8246 LIPPSFTKRLSETVEETEGNS 8266
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 6/169 (3%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDD--SLYITKVTTIHMGNYTCHASG 325
L C V D + + W ++G L +D ED +L I G Y C AS
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLP--PGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720
Query: 326 HEQLFQ-THVLQVNVPP-VIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVST 383
+ + V PP ++ S PG +A L C +G P+ ++TW KN ++S
Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSE 3780
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+ ++ + + + L I+ V+ ED+G+Y+C A N+VG D + + I++
Sbjct: 3781 SNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829
Score = 65.1 bits (157), Expect = 3e-10
Identities = 43/179 (24%), Positives = 75/179 (41%), Gaps = 4/179 (2%)
Query: 261 TVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYT 320
T+G C ++G + W ++G+ L + +L I + H+G Y
Sbjct: 7128 TLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYN 7187
Query: 321 CHASGHEQLFQTHVLQV----NVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
C AS + + VPP + P S G + + +CH G +ITW K
Sbjct: 7188 CSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAK 7247
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
+ ++ + +++L+ N + L + V D G YTC A N G D + L +++ R
Sbjct: 7248 DNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPR 7306
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 5/193 (2%)
Query: 245 VQLSLAP--EDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGE 302
+++ AP + ++ V +G TC + W + G + D I
Sbjct: 3450 MEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKY 3509
Query: 303 DDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS 359
SL I + + G YTC AS G T + PP P+S G AA
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
C G P+ W K+G +S + ++S N L +S++ +D G Y+C A N+
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 420 GVDEDISSLFIED 432
G D + L I D
Sbjct: 3630 GADICQAELIIID 3642
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/168 (27%), Positives = 72/168 (42%), Gaps = 1/168 (0%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L C + G L + W ++G + D I SL I +V GN+TC A+
Sbjct: 4132 LDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSV 4191
Query: 328 -QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMS 386
+ L V PP P S+ PG A L+ +G I W K ++ + S
Sbjct: 4192 GSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGS 4251
Query: 387 KQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSA 434
++ A S L + V+ D+G YTC N G E ++LF+++ A
Sbjct: 4252 CYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPA 4299
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/133 (29%), Positives = 60/133 (45%), Gaps = 2/133 (1%)
Query: 303 DDSLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPV-IRVYPESQAQEPGVAASL 360
+ SL + V T G YTC S + L V P + SQ + G A L
Sbjct: 4260 ESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQL 4319
Query: 361 RCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
C G P +ITW N ++ ++S + + + L ++ V ED+G Y C A+NE G
Sbjct: 4320 ACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAG 4379
Query: 421 VDEDISSLFIEDS 433
D S + +++S
Sbjct: 4380 SDHCSSIVIVKES 4392
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/174 (25%), Positives = 69/174 (39%), Gaps = 1/174 (0%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G S L C + G + W RN L+ +++ L I + + G+Y C
Sbjct: 6379 GESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICE 6438
Query: 323 A-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
A +G + L V PPV P G L+C G P + W+K+ V
Sbjct: 6439 AHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQV 6498
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
+++ + LHI ++ D G Y C A NEVG D S+ ++ R
Sbjct: 6499 RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPR 6552
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 6/183 (3%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIW-KRNGLTLNFLDLEDINDFGEDDSLYITKVT 312
++S + VG L + G ++W K G + D I+ +L ++V
Sbjct: 7497 KLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVE 7556
Query: 313 TIHMGNYTCHA---SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
+ G YTC +G ++ F T L V P I PES G +L C G P
Sbjct: 7557 PANAGKYTCQIKNDAGMQECFAT--LSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPE 7614
Query: 370 PRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLF 429
W K+G ++++ ++S S L I +V D+G Y+ +N VG D +SL
Sbjct: 7615 LSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQ 7674
Query: 430 IED 432
+ D
Sbjct: 7675 VSD 7677
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 3/178 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V G S+ L C + G ++W RN L D + + + ++T G++
Sbjct: 5435 VKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDF 5494
Query: 320 TCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
C A T V+ V PPV +P SL C G P + W K+
Sbjct: 5495 ICEAQNPAGSTSCSTKVI-VKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKD 5553
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
+ + +++ + +HI +V D G Y C A+NEVG D + ++ +++ R
Sbjct: 5554 KRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPR 5611
Score = 57.8 bits (138), Expect = 4e-08
Identities = 52/204 (25%), Positives = 84/204 (41%), Gaps = 9/204 (4%)
Query: 235 LREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
++E + V++ + E S+ VT G + L C V G W ++G L +
Sbjct: 7573 MQECFATLSVLEPATIVEKPESIK-VTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK 7631
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVN---VPPVIRVYPE 348
I+ F + L I V G Y+ G + T LQV+ VPP +
Sbjct: 7632 YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSC--TASLQVSDRTVPPSFTRKLK 7689
Query: 349 SQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDT 408
G + + C G P ++W G ++S+ Q +L N L ++ + D+
Sbjct: 7690 ETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDS 7749
Query: 409 GAYTCIAKNEVGVDEDISSLFIED 432
G YTCIA N G DE + L + +
Sbjct: 7750 GDYTCIATNMAGSDECSAPLTVRE 7773
Score = 57.0 bits (136), Expect = 7e-08
Identities = 45/174 (25%), Positives = 72/174 (41%), Gaps = 5/174 (2%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
+G S + C V G L W ++G ++ + SL + + NYTC
Sbjct: 5250 LGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTC 5309
Query: 322 HAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG 378
S G + + +L V PP V P Q P + +G P +I W K+
Sbjct: 5310 KVSNVAGDDAC--SGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDD 5367
Query: 379 VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
V++ + + L + S L++ SV TG YTC N+VG D + L + +
Sbjct: 5368 VELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTE 5421
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/202 (24%), Positives = 80/202 (39%), Gaps = 5/202 (2%)
Query: 235 LREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDL 294
+RE V++ ++ E + TVTVG + L C V G + W ++G L
Sbjct: 5691 MRENMATLMVLEPAVIVE-KAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQK 5749
Query: 295 EDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQ-THVLQVN---VPPVIRVYPESQ 350
+ + + SL I V G YT + T V+ V+ VPP ++
Sbjct: 5750 HKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNT 5809
Query: 351 AQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGA 410
G + L C G + W + + Q + N L ++S+ D G
Sbjct: 5810 GGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGN 5869
Query: 411 YTCIAKNEVGVDEDISSLFIED 432
YTC+A N G DE + L +++
Sbjct: 5870 YTCVAANVAGSDECRAVLTVQE 5891
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/163 (24%), Positives = 64/163 (39%), Gaps = 2/163 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V G S C V G I W ++ + I G L I KV G Y
Sbjct: 6282 VIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQY 6341
Query: 320 TCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
TC A+ + + + P ++ S+ + G + L C G P +++W +N
Sbjct: 6342 TCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRN 6401
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++ +S + + + L I+ ED+G Y C A N VG
Sbjct: 6402 DSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVG 6444
Score = 55.8 bits (133), Expect = 2e-07
Identities = 28/107 (26%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 338 NVPPVIRVYPE---SQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLAN 394
NVPP++ PE + G + ++ +G P+PR+TW K+GV++ +M+ +++ +
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG 28012
Query: 395 GSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANI 441
+ L + + G YT AKN G + + ++D+ K + I
Sbjct: 28013 STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPI 28059
Score = 55.5 bits (132), Expect = 2e-07
Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 5/161 (3%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G ST C + G + + W +G + + I+ + I+ + G Y C
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCE 4935
Query: 323 ASGHEQLFQTHV-LQVNVPPVI--RVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGV 379
A + L+V PP + P + V L C G P +TWLKN
Sbjct: 4936 ARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDV--ELECEVTGTPPFEVTWLKNNR 4993
Query: 380 DVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++ + L+ + LHI+ DTG Y CI NE G
Sbjct: 4994 EIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG 5034
Score = 55.1 bits (131), Expect = 3e-07
Identities = 47/184 (25%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHM----- 316
+G S VL C V G + W F D +I + S + V T+++
Sbjct: 6754 LGASVVLECRVSGSAPISVGW--------FQDGNEIVSGPKCQSSFSENVCTLNLSLLEP 6805
Query: 317 ---GNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMP 370
G YTC A+ G ++ + VL V PP P+S PG++ + G P
Sbjct: 6806 SDTGIYTCVAANVAGSDEC--SAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPF 6863
Query: 371 RITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
++ W K ++ S +SL +EL + V+ ++G Y+C+ N+ G + LF+
Sbjct: 6864 KVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFV 6923
Query: 431 EDSA 434
++ A
Sbjct: 6924 KEPA 6927
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 270 CAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHM--------GNYTC 321
C + G ++W + D +I + + ++ V + M G+YTC
Sbjct: 7327 CKIGGSPEIKVLW--------YKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTC 7378
Query: 322 HA-SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVD 380
A + + L+V PP+ R P G L C +G P ++W K+ +
Sbjct: 7379 EAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRE 7438
Query: 381 VSTQMSKQLSLLANG--SELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR--K 436
+ + K+ +++ + +HI +V D G Y C A N+VG D + S+ ++ R K
Sbjct: 7439 LRS--GKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVK 7496
Query: 437 TLANI 441
L++I
Sbjct: 7497 KLSDI 7501
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/105 (29%), Positives = 49/105 (46%)
Query: 327 EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMS 386
E+ T ++ + I P S G +A C +G P+P +TWL+ G +ST
Sbjct: 32547 EEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606
Query: 387 KQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
Q++ S ISSV+ D G Y+ + +N G E +L I+
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 32651
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/171 (25%), Positives = 65/171 (38%), Gaps = 5/171 (2%)
Query: 282 WKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQ-----THVLQ 336
W NG+ L + G D +L I + + G TC + E + + T +
Sbjct: 33070 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE 33129
Query: 337 VNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
++ P P SQ G C G P P I W KN + +S + +S N
Sbjct: 33130 LSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVY 33189
Query: 397 ELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEG 447
L I + D+G YT AKN G +SL + + ++ R G
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSG 33240
Score = 53.5 bits (127), Expect = 8e-07
Identities = 39/168 (23%), Positives = 70/168 (41%), Gaps = 5/168 (2%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS--- 324
L C V G I W ++ ++ + + L I+++ G YTC A+
Sbjct: 4694 LECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKA 4753
Query: 325 GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQ 384
GH Q + L V PP P+SQ P L+ G I W K+ ++ +
Sbjct: 4754 GHNQC--SGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSG 4811
Query: 385 MSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
++ + + L + + + D+G Y C N+VG ++LF+++
Sbjct: 4812 AARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859
Score = 53.5 bits (127), Expect = 8e-07
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 3/170 (1%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHAS--G 325
L C V G + W +N + + D +L+ITK G Y C S G
Sbjct: 4974 LECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEG 5033
Query: 326 HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
T V P I+ E+ +A+ + G P ITWLK+ +
Sbjct: 5034 GSCSCSTRVALKEPPSFIKKI-ENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD 5092
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
+ +S + + + L I SV +G YTC AKNE GV+ + L +++ A+
Sbjct: 5093 NVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Score = 53.5 bits (127), Expect = 8e-07
Identities = 51/209 (24%), Positives = 76/209 (36%), Gaps = 8/209 (3%)
Query: 261 TVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYT 320
T G S L V G + W +N + + +I L + K G YT
Sbjct: 8262 TEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYT 8321
Query: 321 CHASGH--EQLFQTHVL--QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
C S L + ++ + PPV + G L CH +G RI WLK
Sbjct: 8322 CKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLK 8381
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARK 436
G ++ S + + L + V D+G Y C A N G D S + I+D
Sbjct: 8382 AGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAV 8441
Query: 437 TLANILWREEGLSVGNMFYVFSDDGIIVI 465
A ++ G +F+V I V+
Sbjct: 8442 APAT----KKAAVDGRLFFVSEPQSIRVV 8466
Score = 53.5 bits (127), Expect = 8e-07
Identities = 31/91 (34%), Positives = 43/91 (47%)
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P IR + + G AA L C G P+P I W + G ++ ++S L +
Sbjct: 30533 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 30592
Query: 401 SSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ED G YTCIA NEVG E S L ++
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 30623
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 23/179 (12%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
++ TT + S V G I W L+D EDD++YI+ V +
Sbjct: 5053 KIENTTTVLKSSATFQSTVAGSPPISITW-----------LKDDQILDEDDNVYISFVDS 5101
Query: 314 I-----------HMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLR 361
+ H G YTC A + + + L V P I +S +L
Sbjct: 5102 VATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLE 5161
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
C G P ++ WLK+G + +S N + I SV +D+G YT +N+ G
Sbjct: 5162 CVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/168 (24%), Positives = 64/168 (38%), Gaps = 1/168 (0%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R+S +V G S +L G L + WK++G + + +I + L I T
Sbjct: 5991 RLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTK 6050
Query: 314 IHMGNYTCHASGHEQLFQTHVLQVNV-PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
G Y+C L + PP E G + SL+C G P +
Sbjct: 6051 RDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITV 6110
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+W K + + N + L + V D+G YTC A+N +G
Sbjct: 6111 SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/148 (27%), Positives = 62/148 (41%), Gaps = 7/148 (4%)
Query: 278 PPI--IWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH---ASGHEQLFQT 332
PPI WK+NG+ + +I + L I T G Y C+ ASG + +
Sbjct: 7895 PPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSC--S 7952
Query: 333 HVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLL 392
+ + PP E G +ASL+C G P ++W K + + ++
Sbjct: 7953 AQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFR 8012
Query: 393 ANGSELHISSVRYEDTGAYTCIAKNEVG 420
N + L + V D+G Y C A+N VG
Sbjct: 8013 NNVATLVFNQVDINDSGEYICKAENSVG 8040
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/178 (24%), Positives = 72/178 (40%), Gaps = 6/178 (3%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDD--SLYITKVTTIHMG 317
V G + + G P + W R+G ++ L + D L I VT + G
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76
Query: 318 NYTCHAS-GHEQLFQTHVLQVNV---PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
Y+ A+ G Q T L V PP +S G L+ GIP P +
Sbjct: 77 RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
+ ++G ++ + + Q+S + L I+ ED+G Y+ A N VG + L ++
Sbjct: 137 FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 50.1 bits (118), Expect = 9e-06
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCI 414
G + +L CH G P P +TW + + + + Q++ + + L I ED+G +TC
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 415 AKNEVG 420
A NE G
Sbjct: 1017 AVNEAG 1022
Score = 49.7 bits (117), Expect = 1e-05
Identities = 40/182 (21%), Positives = 68/182 (37%), Gaps = 1/182 (0%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R+ T +G S +L C V G + W + +L + + +
Sbjct: 5805 RLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDS 5864
Query: 314 IHMGNYTCHASGHEQLFQTH-VLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
MGNYTC A+ + VL V PP PE PG + G P ++
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKV 5924
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
W + ++ + +EL + ++ +G YTC+ N G + LF+++
Sbjct: 5925 NWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKE 5984
Query: 433 SA 434
A
Sbjct: 5985 PA 5986
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/191 (22%), Positives = 72/191 (37%), Gaps = 11/191 (5%)
Query: 247 LSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSL 306
+ LAP D V VG S C V G + W ++ + I+ L
Sbjct: 8157 IRLAPVDAV------VGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHL 8210
Query: 307 YITKVTTIHMGNYTCHASGH----EQLFQTHVLQVNVPPVI-RVYPESQAQEPGVAASLR 361
+ KV G YTC+A Q ++ + +PP + E+ + G + L
Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLE 8270
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
G + W KN +++ + +++ N L + D G YTC N+ G
Sbjct: 8271 GRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGS 8330
Query: 422 DEDISSLFIED 432
SS+ I++
Sbjct: 8331 ALCTSSIVIKE 8341
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 2/122 (1%)
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
G L + V G YTCH + T +L P ++ S+ + G ++
Sbjct: 5382 GSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSS 5441
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
L C G P R+ W +N ++ +++ + + + + ++++ ED+G + C A+N
Sbjct: 5442 RLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNP 5501
Query: 419 VG 420
G
Sbjct: 5502 AG 5503
Score = 48.5 bits (114), Expect = 3e-05
Identities = 49/197 (24%), Positives = 82/197 (41%), Gaps = 11/197 (5%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G +L C + G ++W ++ + I D SL+I + +G Y C
Sbjct: 6472 GSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCK 6531
Query: 323 ASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN-GV 379
A+ +E T V PP + G A LR EG + WLK+ G
Sbjct: 6532 AT-NEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGE 6590
Query: 380 DVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLA 439
+ + ++S + N + L + S ++G Y C KN+ G+ E + L + + AR
Sbjct: 6591 VIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPAR---- 6646
Query: 440 NILWREEGLSV--GNMF 454
I+ + E ++V GN F
Sbjct: 6647 -IIEKPEPMTVTTGNPF 6662
Score = 48.5 bits (114), Expect = 3e-05
Identities = 40/174 (22%), Positives = 67/174 (38%), Gaps = 1/174 (0%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCH 322
G S V+ C V+G + W G ++ +L + + G+YTC
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755
Query: 323 ASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDV 381
A+ + L V PP P+ G + +G P ++W K ++
Sbjct: 7756 ATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSEL 7815
Query: 382 STQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
+SL + +EL + V +G YTCI NE G + L+I+ A+
Sbjct: 7816 VPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAK 7869
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/181 (22%), Positives = 68/181 (37%), Gaps = 2/181 (1%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIW-KRNGLTLNFLDLEDINDFGEDDSLYITKVT 312
++S T+ +G + L V G ++W K G + + I+ +L +
Sbjct: 6556 KLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPE 6615
Query: 313 TIHMGNYTCHASGHEQLFQ-THVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPR 371
+ G Y C + + + VL V P I PE G +L C G P
Sbjct: 6616 ASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELS 6675
Query: 372 ITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
W K+G ++S ++ + + L I D G Y+ KN VG S+ +
Sbjct: 6676 AKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVS 6735
Query: 432 D 432
D
Sbjct: 6736 D 6736
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/177 (23%), Positives = 73/177 (41%), Gaps = 6/177 (3%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
+ +G S C V G I W ++ + + +L + KV G Y
Sbjct: 7223 LALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQY 7282
Query: 320 TCHAS---GHEQLFQTHVLQVNVPP-VIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
TC+AS G + + L V PP I+ S+ + C G P ++ W
Sbjct: 7283 TCYASNIAGKDSC--SAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWY 7340
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
K+ ++ ++S + + + L + ++ ED+G YTC A N G +SL +++
Sbjct: 7341 KDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE 7397
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/135 (22%), Positives = 58/135 (42%), Gaps = 3/135 (2%)
Query: 305 SLYITKVTTIHMGNYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRC 362
SL I K G Y C + + V P I+ + + G AA
Sbjct: 4449 SLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQAT 4508
Query: 363 HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+P+ +TWLK+ +++ + +++ N + L++S + + G Y C AKN+ G+
Sbjct: 4509 LKGSLPIT-VTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQ 4567
Query: 423 EDISSLFIEDSARKT 437
+ L +++ A T
Sbjct: 4568 RCSALLSVKEPATIT 4582
Score = 47.8 bits (112), Expect = 4e-05
Identities = 43/173 (24%), Positives = 63/173 (36%), Gaps = 3/173 (1%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
V G + T V G + W + L D +++ L + V T G Y
Sbjct: 7786 VLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEY 7845
Query: 320 TCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
TC S + TH L + P + E G L G P +TW KN
Sbjct: 7846 TCIVSNEAGKASCTTH-LYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKN 7904
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
G++V+ ++ + L I S ED G Y C +N G D + + I
Sbjct: 7905 GINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Score = 47.4 bits (111), Expect = 6e-05
Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 12/149 (8%)
Query: 284 RNGLTLNFLDLEDINDFGEDD-----------SLYITKVTTIHMGNYTCHASGHEQLFQ- 331
+ L + L+D ++ EDD SLY++ + H G Y C A + +
Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRC 4569
Query: 332 THVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSL 391
+ +L V P I S G A+L+ G W K+G +++ ++S+
Sbjct: 4570 SALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISV 4629
Query: 392 LANGSELHISSVRYEDTGAYTCIAKNEVG 420
S L I S +D+G YT +N+VG
Sbjct: 4630 TDTVSILKIISTEKKDSGEYTFEVQNDVG 4658
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/156 (28%), Positives = 66/156 (42%), Gaps = 11/156 (7%)
Query: 282 WKRNGLTLNFLDLEDINDFGED--DSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNV 339
W ++G+ +NF E E ++I++ G YT A + + L VN
Sbjct: 3179 WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRS---SVTLYVNA 3235
Query: 340 PPVIRVYPESQ--AQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE 397
P +V E Q + G A G P P+I+W K +ST + L +G E
Sbjct: 3236 PEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGF--KCKFLHDGQE 3293
Query: 398 LHISSVRY--EDTGAYTCIAKNEVGVDEDISSLFIE 431
+ + ED YTC AKN+ GV +SL +E
Sbjct: 3294 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE 3329
Score = 46.6 bits (109), Expect = 1e-04
Identities = 45/184 (24%), Positives = 74/184 (40%), Gaps = 3/184 (1%)
Query: 254 RVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTT 313
R++ +V G VL G + W ++ ++ + I + L I + T
Sbjct: 6932 RLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTI 6991
Query: 314 IHMGNYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
Y+C Q ++ V PP E G A+L+C +G P RI
Sbjct: 6992 EDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRI 7051
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+W K + + + ++ N + L I+ V + D G Y+C A N VG + L I+
Sbjct: 7052 SWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIK- 7110
Query: 433 SARK 436
ARK
Sbjct: 7111 -ARK 7113
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANG-SELHISSVRYEDTGAYTC 413
G+ + C G P+P+I W K+G + Q+ L +G + L I V ED G YT
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 414 IAKNEVGVDEDISSLFIEDSA 434
A N G L++E +A
Sbjct: 1365 FASNIKGNAICSGKLYVEPAA 1385
Score = 46.2 bits (108), Expect = 1e-04
Identities = 42/186 (22%), Positives = 68/186 (36%), Gaps = 8/186 (4%)
Query: 262 VGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTC 321
VG S L C V G + W + L +L KV G YTC
Sbjct: 6092 VGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTC 6151
Query: 322 HA------SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
A + + +F+ Q+ PP + Q G+ +L C G ++ W
Sbjct: 6152 KAENSIGTASSKTVFRIQERQL--PPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWY 6209
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSAR 435
++GV + + Q S + N + L I +G Y+C A N +G + L + +
Sbjct: 6210 RDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKK 6269
Query: 436 KTLANI 441
+I
Sbjct: 6270 SPFFDI 6275
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/168 (30%), Positives = 71/168 (42%), Gaps = 22/168 (13%)
Query: 259 TVTVGLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
TVT G + C + + D+ P+ W G L D G KV T+ +
Sbjct: 12206 TVTAGETATFDCELSYEDI--PVEWYLKGKKLEPSDKVVPRSEG--------KVHTLTLR 12255
Query: 318 NYTCHASGHEQL----FQTHV-LQVNVPPVIRVYP-ESQAQEPGVAASLRCHAEGIPMPR 371
+ +G QL F+TH L V PPV P E Q E G A L C +
Sbjct: 12256 DVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSR-ENAK 12314
Query: 372 ITWLKNGVDVSTQMSKQLSLLANG--SELHISSVRYEDTGAYTCIAKN 417
+ W KNG ++ SK+ ++A+G +L I ED YTC AK+
Sbjct: 12315 VKWFKNGTEI--LKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 12360
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/170 (26%), Positives = 68/170 (40%), Gaps = 22/170 (12%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLY---ITKVTTIHMGNYTCHAS 324
+T VH + P + W ++G + D + F D LY I VTT YT A
Sbjct: 31711 VTITVHPE--PHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVAR 31768
Query: 325 ---GHEQLFQTHVLQVNVPPVI--------RVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
G + + ++ PP R+ ++ QE G + GIP P +
Sbjct: 31769 NKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE-GQSVCFEIRVSGIPPPTLK 31827
Query: 374 WLKNGVDVSTQMSKQLSLLANGSE---LHISSVRYEDTGAYTCIAKNEVG 420
W K+G +S + + ++ G + LHI EDTG Y A N G
Sbjct: 31828 WEKDGQPLS--LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAG 31875
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/170 (24%), Positives = 70/170 (41%), Gaps = 4/170 (2%)
Query: 268 LTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHE 327
L C + G ++W ++ L I S++I V T +G Y C A +E
Sbjct: 5536 LECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQ-NE 5594
Query: 328 QLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
T V V + PP S G A L+ EG + WLK +V +
Sbjct: 5595 VGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRES 5654
Query: 386 SK-QLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSA 434
+++ + N + L + + G Y C KN+ G+ E++++L + + A
Sbjct: 5655 ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPA 5704
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/131 (25%), Positives = 49/131 (37%), Gaps = 1/131 (0%)
Query: 305 SLYITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCH 363
+L K + G Y C + + L V P VI G +L C
Sbjct: 5667 TLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECK 5726
Query: 364 AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
G P + W K+G +++ + S S L I SV +D G YT +N VG
Sbjct: 5727 VAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSS 5786
Query: 424 DISSLFIEDSA 434
+ + + D A
Sbjct: 5787 CTAVVDVSDRA 5797
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/188 (22%), Positives = 72/188 (38%), Gaps = 17/188 (9%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIW-KRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
TV G + G +P I W K L + ++D G++ +L + +
Sbjct: 3249 TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHD-GQEYTLLLIEAFPEDAA 3307
Query: 318 NYTCHASGHEQLFQTHV-LQVNVPPVIR------VYP-------ESQAQEPGVAASLRCH 363
YTC A + T L V VP V+ VYP + G A +C
Sbjct: 3308 VYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCR 3367
Query: 364 AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDE 423
G + +++W + +++ + +L I+ ED G YT +A N VG
Sbjct: 3368 VSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVS 3426
Query: 424 DISSLFIE 431
++L +E
Sbjct: 3427 STANLSLE 3434
Score = 43.9 bits (102), Expect = 6e-04
Identities = 51/212 (24%), Positives = 78/212 (36%), Gaps = 17/212 (8%)
Query: 226 DYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGD--LRPPIIWK 283
D S L L Y Q+ + ++ D S+ G + GD LRP +K
Sbjct: 7949 DSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYK 8008
Query: 284 ---RNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVP 340
RN + + DIND GE YI K +G + F T V + +P
Sbjct: 8009 MHFRNNVATLVFNQVDINDSGE----YICKAEN-SVGEVSAST------FLT-VQEQKLP 8056
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
P + G+ C G ++W K+G + + Q S L N + L+I
Sbjct: 8057 PSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNI 8116
Query: 401 SSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
G Y+C A N +G + L + +
Sbjct: 8117 FKTDRSLAGQYSCTATNPIGSASSSARLILTE 8148
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/95 (28%), Positives = 38/95 (40%)
Query: 326 HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQM 385
HE++ Q +++ PVI+ E G A C + P R W K G ++
Sbjct: 3441 HERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESD 3500
Query: 386 SKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ S L I + D G YTC A NE G
Sbjct: 3501 KCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 3535
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/105 (31%), Positives = 47/105 (44%), Gaps = 5/105 (4%)
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE-LH 399
P I +YPE G A RC G P P++ W NG + + SK+ + +G L
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLI--RKSKRFRVRYDGIHYLD 1898
Query: 400 ISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWR 444
I + DTG A+N GV E L I+ R+ ++L R
Sbjct: 1899 IVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ--REDFRSVLRR 1941
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/100 (26%), Positives = 43/100 (43%)
Query: 333 HVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLL 392
+VL + +PP + G L C G I W K+ ++S + S
Sbjct: 4667 NVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFH 4726
Query: 393 ANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
N + L IS + D+G YTC A N+ G ++ L +++
Sbjct: 4727 DNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 306 LYITKVTTIHMGNYTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRC 362
L I + +G Y C + G TH+L+ PP + G +L+
Sbjct: 3888 LEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE--PPTFVKKVDDLIALGGQTVTLQA 3945
Query: 363 HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANG-SELHISSVRYEDTGAYTCIAKNEVGV 421
G +TW+K G +V + K +NG + L I V+ G YTC+A+NE G
Sbjct: 3946 AVRGSEPISVTWMK-GQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 4004
Query: 422 DEDISSLFIEDSAR 435
+ L +++ A+
Sbjct: 4005 QTSVGELIVKEPAK 4018
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/166 (24%), Positives = 61/166 (36%), Gaps = 5/166 (3%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDD--SLYITKVTTIHMG 317
V G + T + G + W R L + + N + ED L + + G
Sbjct: 5904 VLPGKNVTFTSVIRGTPPFKVNWFRGAREL--VKGDRCNIYFEDTVAELELFNIDISQSG 5961
Query: 318 NYTCHASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK 376
YTC S + Q T L V P + EPG + L G +TW K
Sbjct: 5962 EYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKK 6021
Query: 377 NGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVD 422
+G +++T + L I + D G Y+C +NE G D
Sbjct: 6022 DGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 41.6 bits (96), Expect = 0.003
Identities = 46/177 (25%), Positives = 69/177 (38%), Gaps = 9/177 (5%)
Query: 265 STVLTCAVHGDLRPPIIWKRNGLTLNFLDLE-DINDF-GEDDSLYITKVTTIHMGNYTCH 322
+ L C V G +P + W R G + L+ I +F G L I VT Y
Sbjct: 30944 NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVR 31003
Query: 323 ASGHE-QLFQTHVLQVNVPPVIRVYPESQAQEP-----GVAASLRCHAEGIPMPRITWLK 376
A+ + T L+V VP I + + G S++ G P P ITW K
Sbjct: 31004 ATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQK 31063
Query: 377 NGVDVSTQMSKQLSLLANGSELHI-SSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+ Q+ + + + L + V +D G Y AKN G+D+ L + D
Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 4/74 (5%)
Query: 349 SQAQEPGVAASLRCHA--EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYE 406
++ Q V +LR A +G+P P++TW K D T+ ++ + GS+L I + +E
Sbjct: 17225 AREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTK--ARIDVTPVGSKLEIRNAAHE 17282
Query: 407 DTGAYTCIAKNEVG 420
D G Y+ +N G
Sbjct: 17283 DGGIYSLTVENPAG 17296
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%)
Query: 334 VLQVNVPPVIRVYPESQAQ---EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLS 390
+L NVPP I + ++ + G L G PMP ++W K+G + +++
Sbjct: 19286 ILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMA 19345
Query: 391 LLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ N L + SV +D+G YT A+N G
Sbjct: 19346 MQRNLCTLELFSVNRKDSGDYTITAENSSG 19375
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 11/154 (7%)
Query: 279 PIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVN 338
P +W +NG+ + + I G+ L I +T YT G++Q+ T L V
Sbjct: 2911 PSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT-FVCGNDQVSAT--LTVT 2967
Query: 339 VPPVIRVYPESQAQEPG-VAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE 397
+ + + A+E + + + EGI WLKNGV++ + Q+
Sbjct: 2968 PIMITSMLKDINAEEKDTITFEVTVNYEGISYK---WLKNGVEIKSTDKCQMRTKKLTHS 3024
Query: 398 LHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
L+I +V + D YT +A G ++L++E
Sbjct: 3025 LNIRNVHFGDAADYTFVA----GKATSTATLYVE 3054
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/136 (27%), Positives = 56/136 (41%), Gaps = 13/136 (9%)
Query: 306 LYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQE--PGVAASLRCH 363
L I V G YTC A +E QT V ++ V ++ ++ + G A+L
Sbjct: 3981 LIIPDVQISFGGKYTCLAE-NEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039
Query: 364 AEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG--- 420
G P + W K+G + ++S N ++L S D+G YT NEVG
Sbjct: 4040 VAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSS 4099
Query: 421 -------VDEDISSLF 429
+D DI+ F
Sbjct: 4100 CETTFTVLDRDIAPFF 4115
Score = 40.4 bits (93), Expect = 0.007
Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 2/94 (2%)
Query: 339 VPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSL--LANGS 396
+PP I P + + G ++ C G P P +TW G + +Q + + + +
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386
Query: 397 ELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
L I V+ +D G YT NE G D ++ I
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 39.7 bits (91), Expect = 0.012
Identities = 23/96 (23%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 337 VNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
+ + P +++ + + + G + G P P I+W+K+G + + A +
Sbjct: 24308 LTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 24367
Query: 397 ELHISSVRYEDTGAYTCIAKNEVG-VDEDISSLFIE 431
LHI +D G YT A N G E++S + +E
Sbjct: 24368 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 24403
Score = 38.9 bits (89), Expect = 0.020
Identities = 27/93 (29%), Positives = 39/93 (41%), Gaps = 2/93 (2%)
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE--L 398
P P Q G + C G P P + W K+GV ++T ++S E L
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141
Query: 399 HISSVRYEDTGAYTCIAKNEVGVDEDISSLFIE 431
IS +D G YT + +N+ G +SL E
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGETSASASLLEE 1174
Score = 38.9 bits (89), Expect = 0.020
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 1/95 (1%)
Query: 339 VPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSEL 398
+PP I + PE + G + H G P P W K +V T + + S L
Sbjct: 18898 LPPKI-LMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 18956
Query: 399 HISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 433
I V +D+G Y+ A+N G D + + D+
Sbjct: 18957 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991
Score = 38.5 bits (88), Expect = 0.026
Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 10/92 (10%)
Query: 339 VPPVIRVYPESQAQEPGVAASLRCH----AEGIPMPRITWLKNGVDV-----STQMSK-Q 388
VPP I++ + V A H G+PMP+I W KN + + Q++K +
Sbjct: 15393 VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE 15452
Query: 389 LSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+S +EL I ED G YT A N +G
Sbjct: 15453 VSRSEAKTELSIPKAVREDKGTYTVTASNRLG 15484
Score = 38.1 bits (87), Expect = 0.034
Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 5/189 (2%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
T +G + L+C + G P I W R G L ++ G +L + G
Sbjct: 30543 TTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGV 30602
Query: 319 YTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAE--GIPMPRITW 374
YTC A+ E + +L P YP + V ++LR H G P+P +TW
Sbjct: 30603 YTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 30662
Query: 375 LKNGVDVSTQMSKQLSLLANGSELHISSV-RYEDTGAYTCIAKNEVGVDEDISSLFIEDS 433
+ + + + + L + +V R G Y N G + I + I+D
Sbjct: 30663 FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDK 30722
Query: 434 ARKTLANIL 442
K I+
Sbjct: 30723 PDKPTGPIV 30731
Score = 38.1 bits (87), Expect = 0.034
Identities = 24/84 (28%), Positives = 32/84 (38%)
Query: 337 VNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
++ PVI + A A G P P W K+G ++ +LS G
Sbjct: 32848 ISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 32907
Query: 397 ELHISSVRYEDTGAYTCIAKNEVG 420
L I D+G YTC KN G
Sbjct: 32908 FLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 37.7 bits (86), Expect = 0.045
Identities = 32/133 (24%), Positives = 56/133 (42%), Gaps = 4/133 (3%)
Query: 305 SLYITKVTTIHMGNYTCHASGHEQLFQTHV--LQVNVPPVIRVYPESQAQEPGVAASLRC 362
S++I V +G Y C A+ ++ T V + + PP + G L+
Sbjct: 7455 SIHILNVDAADIGEYQCKAT-NDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQT 7513
Query: 363 HAEGIPMPRITWLKNGVDVSTQMSK-QLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
EG + W K+ ++ + +S N + L S V + G YTC KN+ G+
Sbjct: 7514 TIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGM 7573
Query: 422 DEDISSLFIEDSA 434
E ++L + + A
Sbjct: 7574 QECFATLSVLEPA 7586
Score = 37.7 bits (86), Expect = 0.045
Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 9/133 (6%)
Query: 297 INDFGEDDS---LYITKVTTIHMGNYTCHASGHEQLFQTHVLQV-NVPPVIRVYPESQAQ 352
+ND+GED S L++ V ++ +Y C + + +T +++ PP + ++
Sbjct: 31644 VNDYGEDSSYAELFVKGVREVY--DYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTA 31701
Query: 353 EPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELH---ISSVRYEDTG 409
G P P +TW K+G + + + + L+ I+SV +D
Sbjct: 31702 YVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDA 31761
Query: 410 AYTCIAKNEVGVD 422
YT +A+N+ G D
Sbjct: 31762 EYTVVARNKYGED 31774
Score = 36.6 bits (83), Expect = 0.100
Identities = 17/66 (25%), Positives = 29/66 (43%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCI 414
G + G P+P I+W K+G+++ + ++ N + L + DTG Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863
Query: 415 AKNEVG 420
KN G
Sbjct: 25864 LKNVAG 25869
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCI 414
G + L G P P ITW K G+D++++ + + S L + V D G YT
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAI--IDTTESYSLLIVDKVNRYDAGKYTIE 29518
Query: 415 AKNEVG 420
A+N+ G
Sbjct: 29519 AENQSG 29524
Score = 36.2 bits (82), Expect = 0.13
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 5/92 (5%)
Query: 335 LQVNVPPVIRVYPESQAQEPGVAASLRCHAEG--IPMPRITWLKNGVDVSTQMSKQLSLL 392
L V+ PP I + +++A + A L C E + +TW K+G + Q
Sbjct: 32712 LPVSAPPKITQFLKAEASKE--IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYS 32769
Query: 393 ANGS-ELHISSVRYEDTGAYTCIAKNEVGVDE 423
A+G+ EL I+++ D G Y C E G +
Sbjct: 32770 ADGTYELKINNLTESDQGEYVCEISGEGGTSK 32801
Score = 35.8 bits (81), Expect = 0.17
Identities = 46/203 (22%), Positives = 76/203 (37%), Gaps = 19/203 (9%)
Query: 252 EDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKV 311
+ ++ TV+ G L+C V G I W + G + D + L + V
Sbjct: 8349 DQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDV 8408
Query: 312 TTIHMGNYTCHASG--HEQLFQTHVLQVNVPPVI----------RVYPESQAQEPGVA-- 357
G+Y C AS ++ V + P V R++ S+ Q V
Sbjct: 8409 AKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEK 8468
Query: 358 --ASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE--LHISSVRYEDTGAYTC 413
A+ G P+P + W K G ++ + G E L I D+G Y C
Sbjct: 8469 TTATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRC 8527
Query: 414 IAKNEVGVDEDISSLFIEDSARK 436
+A NE G E +L +++ ++
Sbjct: 8528 VAFNEHGEIESNVNLQVDERKKQ 8550
Score = 35.8 bits (81), Expect = 0.17
Identities = 19/55 (34%), Positives = 27/55 (49%)
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
+G P P I+WLK+G+ + + S N L I + + E G YT I N V
Sbjct: 27588 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAV 27642
Score = 35.0 bits (79), Expect = 0.29
Identities = 18/55 (32%), Positives = 25/55 (45%)
Query: 366 GIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G P+P+ +W K G D+ Q++ S L I +D G YT A N G
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Score = 34.3 bits (77), Expect = 0.50
Identities = 29/132 (21%), Positives = 51/132 (38%), Gaps = 5/132 (3%)
Query: 282 WKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPP 341
W + L D +I+ G+ +L + GNY H + V++ P
Sbjct: 8690 WYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTVIE----P 8745
Query: 342 VIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHIS 401
+ + + G ++ C +P + W +NG + Q + + +L I+
Sbjct: 8746 AWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIA 8804
Query: 402 SVRYEDTGAYTC 413
VR ED G YTC
Sbjct: 8805 DVRAEDQGQYTC 8816
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/98 (21%), Positives = 42/98 (42%), Gaps = 4/98 (4%)
Query: 326 HEQLFQTHVL--QVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVST 383
HE++ +T +V I+ + + G L+ + G + W+ NGV+++
Sbjct: 33022 HEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGAT--DVKWVLNGVELTN 33079
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
+ + + L I + D G TCI+K + G+
Sbjct: 33080 SEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGI 33117
Score = 33.5 bits (75), Expect = 0.85
Identities = 18/67 (26%), Positives = 29/67 (43%)
Query: 366 GIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDI 425
G P P +TW K + A + L+I+ D+G Y A+N VG D+
Sbjct: 21091 GRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDV 21150
Query: 426 SSLFIED 432
++ + D
Sbjct: 21151 ITIQVHD 21157
Score = 33.5 bits (75), Expect = 0.85
Identities = 23/95 (24%), Positives = 41/95 (43%), Gaps = 3/95 (3%)
Query: 341 PVIRV---YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE 397
P I+V + ++ + G A L G P P + W K+G ++ ++ + +
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN 21518
Query: 398 LHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
L D+GAYT A N G + I ++ + D
Sbjct: 21519 LVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLD 21553
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/104 (23%), Positives = 42/104 (40%), Gaps = 13/104 (12%)
Query: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE-LH 399
PV + P S G A G PMP W +G + + ++ + +G++ L
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 400 ISSVRYEDTGAYTCIAKNEVG------------VDEDISSLFIE 431
I D+G +T +A+N G V+ + +F+E
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVE 1560
Score = 33.1 bits (74), Expect = 1.1
Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 8/126 (6%)
Query: 305 SLYITKVTTIHMGNYTCHA------SGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAA 358
SL I T G +T A S + ++ V P+ ++ + G
Sbjct: 1514 SLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573
Query: 359 SLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSE--LHISSVRYEDTGAYTCIAK 416
++ A G P P I WLKN + ++ + E L I S +D+ YT A
Sbjct: 1574 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1633
Query: 417 NEVGVD 422
N+ G D
Sbjct: 1634 NKAGRD 1639
Score = 33.1 bits (74), Expect = 1.1
Identities = 13/44 (29%), Positives = 22/44 (50%)
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAK 416
TW+K+G ++ + +LHI V+ D G YTC+ +
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLR 11193
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 8/90 (8%)
Query: 338 NVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLK-------NGVDVSTQMSKQLS 390
++PP I + E E G ++ +G+P P +TW K N V
Sbjct: 16115 DMPPSIDL-KEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKL 16173
Query: 391 LLANGSELHISSVRYEDTGAYTCIAKNEVG 420
++ + L I R DTG YT A N +G
Sbjct: 16174 VVDDTCTLVIPQSRRSDTGLYTITAVNNLG 16203
Score = 32.7 bits (73), Expect = 1.4
Identities = 19/69 (27%), Positives = 29/69 (42%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCI 414
GV L +G P P+ITW K V++ ++ + + L +V D G Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILT 19767
Query: 415 AKNEVGVDE 423
+N G E
Sbjct: 19768 LENSCGKKE 19776
Score = 32.3 bits (72), Expect = 1.9
Identities = 18/69 (26%), Positives = 29/69 (42%)
Query: 360 LRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEV 419
L+ +G P P ++W K ++T + A + L + + D G YT KN
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 420 GVDEDISSL 428
G E S+
Sbjct: 20062 GTKEGTISI 20070
Score = 32.0 bits (71), Expect = 2.5
Identities = 17/56 (30%), Positives = 26/56 (46%)
Query: 365 EGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+G P P +TW K+ ++ + + + S L I V DTG Y +N VG
Sbjct: 27296 KGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVG 27351
Score = 31.6 bits (70), Expect = 3.2
Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 4/87 (4%)
Query: 334 VLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLA 393
V++ +V P Y Q+ + + G P P ITW K+G+ + ++
Sbjct: 23227 VIEPDVKPAFSSYSVQVGQDLKIEVPI----SGRPKPTITWTKDGLPLKQTTRINVTDSL 23282
Query: 394 NGSELHISSVRYEDTGAYTCIAKNEVG 420
+ + L I +D G Y N VG
Sbjct: 23283 DLTTLSIKETHKDDGGQYGITVANVVG 23309
Score = 31.2 bits (69), Expect = 4.2
Identities = 18/82 (21%), Positives = 32/82 (39%), Gaps = 1/82 (1%)
Query: 340 PPVIRV-YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSEL 398
PP + + + + G A +L G P P+++W K+ DV + L
Sbjct: 16817 PPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLAL 16876
Query: 399 HISSVRYEDTGAYTCIAKNEVG 420
+ D+G Y + +N G
Sbjct: 16877 EKIKAKRSDSGKYCVVVENSTG 16898
Score = 31.2 bits (69), Expect = 4.2
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 2/75 (2%)
Query: 346 YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRY 405
Y E G L +G P P W K G D+S + ++ +EL I
Sbjct: 30142 YQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKR--AMIATSETHTELVIKEADR 30199
Query: 406 EDTGAYTCIAKNEVG 420
D+G Y + +N+ G
Sbjct: 30200 GDSGTYDLVLENKCG 30214
Score = 30.8 bits (68), Expect = 5.5
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 366 GIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G P P++TW K G+D + Q+ L+ + L I + +D+G Y+ N G
Sbjct: 18632 GRPAPKVTWRKVGID-NVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAG 18685
Score = 30.8 bits (68), Expect = 5.5
Identities = 15/67 (22%), Positives = 29/67 (43%)
Query: 366 GIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDI 425
G P+P++T ++GV + M + A +++ D G Y A N G +
Sbjct: 26502 GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAF 26561
Query: 426 SSLFIED 432
++ + D
Sbjct: 26562 INIVVLD 26568
Score = 30.4 bits (67), Expect = 7.2
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 6/69 (8%)
Query: 355 GVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI---SSVRYEDTGAY 411
G S+ +P+P ++W K+G +V + S +L++ + H+ SVR D G Y
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVR-ADAGIY 14457
Query: 412 TCIAKNEVG 420
T +N++G
Sbjct: 14458 TITLENKLG 14466
Score = 30.4 bits (67), Expect = 7.2
Identities = 20/85 (23%), Positives = 30/85 (35%), Gaps = 3/85 (3%)
Query: 339 VPPVIRV---YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANG 395
VPP + + E + G G+P+P W +G ++ T +
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFS 17565
Query: 396 SELHISSVRYEDTGAYTCIAKNEVG 420
S L I + DTG Y N G
Sbjct: 17566 SVLTIKNCLRRDTGEYQITVSNAAG 17590
Score = 30.4 bits (67), Expect = 7.2
Identities = 20/84 (23%), Positives = 34/84 (40%), Gaps = 3/84 (3%)
Query: 340 PPVIRV---YPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
PP I + Y ++ G + + G P+P I W+K ++S ++ +
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFAT 22599
Query: 397 ELHISSVRYEDTGAYTCIAKNEVG 420
L + D+G Y AKN G
Sbjct: 22600 SLSVKDAVRVDSGNYILKAKNVAG 22623
Score = 30.4 bits (67), Expect = 7.2
Identities = 17/64 (26%), Positives = 27/64 (42%)
Query: 260 VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
+ G + + TC + G+ P I W +N L ++ I+ SL I + G Y
Sbjct: 33145 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 33204
Query: 320 TCHA 323
T A
Sbjct: 33205 TIKA 33208
Score = 30.0 bits (66), Expect = 9.4
Identities = 16/58 (27%), Positives = 26/58 (44%), Gaps = 2/58 (3%)
Query: 363 HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ G P P +TW N + + + A S + I + + G Y+ +AKNE G
Sbjct: 16547 YVSGKPPPTVTWNMN--ERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG 16602
Score = 30.0 bits (66), Expect = 9.4
Identities = 17/55 (30%), Positives = 20/55 (36%)
Query: 366 GIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
G P P +TW K+ V + N S L I ED G Y N G
Sbjct: 22173 GRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/292 (25%), Positives = 119/292 (40%), Gaps = 33/292 (11%)
Query: 171 PASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSD 230
P +Q R V+ + L+A +L ++ DE + C+ + + + S
Sbjct: 157 PKAQVRYSVKQEW--LEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSG 214
Query: 231 SSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLN 290
SS LR + ++ PE + + VT G S +L C G P + W ++G ++
Sbjct: 215 SSDRLRVRRSTAEAARIIYPPEAQTII--VTKGQSLILECVASGIPPPRVTWAKDGSSVT 272
Query: 291 -------FLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNV---- 339
L I+ E+DS G Y C A V+ NV
Sbjct: 273 GYNKTRFLLSNLLIDTTSEEDS-----------GTYRCMADNGVGQPGAAVILYNVQVFE 321
Query: 340 PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELH 399
PP + + G +A L C G P P + WL+N V + + +LS A L
Sbjct: 322 PPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRA----LR 377
Query: 400 ISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVG 451
+ S+ ED G Y C+A+NEVG + L ++R ++ LW++ L+ G
Sbjct: 378 VLSMGPEDEGVYQCMAENEVGSAHAVVQL---RTSRPSITPRLWQDAELATG 426
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 9/105 (8%)
Query: 337 VNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGS 396
+N P + V P S Q+PG L C E P +TW NG +++ L +L
Sbjct: 32 LNEVPQVTVQPASTVQKPGGTVILGCVVEP-PRMNVTWRLNGKELNGS-DDALGVLITHG 89
Query: 397 ELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANI 441
L I+++ G Y C+A+ G + A TLAN+
Sbjct: 90 TLVITALNNHTVGRYQCVARMPAGAVASV-------PATVTLANL 127
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/188 (29%), Positives = 84/188 (44%), Gaps = 16/188 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL-----NFLDLEDINDFGEDDSLYITKVTT 313
TV+ G + VL+C V G+ + W R+ L L D+ SL I+ +
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL-------SLEISGIIP 462
Query: 314 IHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
G Y C AS + + V L V P + ++ SQ GV + C A G P P I
Sbjct: 463 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 522
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+W + + Q ++ + A G+ L I V ED G Y+C A NEVG D++ +L+ D
Sbjct: 523 SWSRESQ--ALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 579
Query: 433 SARKTLAN 440
+ N
Sbjct: 580 PPSVSAVN 587
Score = 63.5 bits (153), Expect = 8e-10
Identities = 59/189 (31%), Positives = 75/189 (39%), Gaps = 9/189 (4%)
Query: 251 PEDRVSVTTVTV--GLSTVLTCAV-HGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLY 307
P+ S TV V G L C V G P W ++G L I D SL+
Sbjct: 768 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR---ADGSLH 824
Query: 308 ITKVTTIHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEG 366
+ + H G Y+C A+ V L V VPP I GV ASL C A G
Sbjct: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASG 884
Query: 367 IPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDIS 426
+P P ITW K + T ++ G+ L I+ +D GAY C A N VG
Sbjct: 885 VPAPTITWTKE-TNALTSRGPHYNVSKEGT-LLIAQPSAQDAGAYVCTATNTVGFSSQEM 942
Query: 427 SLFIEDSAR 435
L + R
Sbjct: 943 RLSVNTKPR 951
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 23/225 (10%)
Query: 203 VLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTT--- 259
V + DL ++ G P D R+ S+++ R V L + +VS+ T
Sbjct: 447 VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS------VWLLVREAPQVSIHTSSQ 500
Query: 260 -VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+ G+ ++C+ G P I W R L ++ G +L I V GN
Sbjct: 501 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGN 557
Query: 319 YTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y+C A+ G +Q +T L PP + G A L C A G+P PR+ W
Sbjct: 558 YSCQATNEVGTDQ--ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 615
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ G+++ ++ +L I + + D G YTC A NE+G
Sbjct: 616 RGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELG 655
Score = 57.0 bits (136), Expect = 7e-08
Identities = 51/190 (26%), Positives = 71/190 (37%), Gaps = 10/190 (5%)
Query: 256 SVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIH 315
+V V VG VL C G P +IW R GL + + L I
Sbjct: 588 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP-----EGSSSGKLRIPAAQERD 642
Query: 316 MGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITW 374
G YTC A + L V P + P E G +A L C A G P P +TW
Sbjct: 643 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 702
Query: 375 LK-NGVDVSTQMSK---QLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
+ +G + ++ S + L SV ED Y C A+N G + + L +
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 431 EDSARKTLAN 440
A +A+
Sbjct: 763 TGHAPPQIAS 772
Score = 54.3 bits (129), Expect = 5e-07
Identities = 47/168 (27%), Positives = 70/168 (41%), Gaps = 16/168 (9%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKR--NGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYT 320
G+ L C G P I W + N LT + ++ +L I + + G Y
Sbjct: 873 GVPASLPCVASGVPAPTITWTKETNALTSRGPHY----NVSKEGTLLIAQPSAQDAGAYV 928
Query: 321 CHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEP-------GVAASLRCHAEGIPMPRI 372
C A+ + L VN P I + A P G +L C A+G P P +
Sbjct: 929 CTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
TW K+ V ++ + LL +GS L ++ V+ D+G Y C A N G
Sbjct: 989 TWTKDSRPV-PPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASNPAG 1034
Score = 38.5 bits (88), Expect = 0.026
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 10/175 (5%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGH 326
+++C+VH L + +R L + + G + S I + + G Y C A
Sbjct: 328 LVSCSVHSALPFRLQLRRGEARLG--EERHFQESG-NSSWEILRASKAEEGTYECTAVSR 384
Query: 327 EQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG--VDVST 383
+ + V PP V + PG A L C G +TW+++ + ST
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 444
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTL 438
QL+ L+ L IS + D G Y C+A N GV L + ++ + ++
Sbjct: 445 GRVAQLADLS----LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 495
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/188 (29%), Positives = 84/188 (44%), Gaps = 16/188 (8%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTL-----NFLDLEDINDFGEDDSLYITKVTT 313
TV+ G + VL+C V G+ + W R+ L L D+ SL I+ +
Sbjct: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL-------SLEISGIIP 578
Query: 314 IHMGNYTCHASGHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRI 372
G Y C AS + + V L V P + ++ SQ GV + C A G P P I
Sbjct: 579 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 638
Query: 373 TWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIED 432
+W + + Q ++ + A G+ L I V ED G Y+C A NEVG D++ +L+ D
Sbjct: 639 SWSRESQ--ALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 695
Query: 433 SARKTLAN 440
+ N
Sbjct: 696 PPSVSAVN 703
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 23/225 (10%)
Query: 203 VLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTT--- 259
V + DL ++ G P D R+ S+++ R V L + +VS+ T
Sbjct: 563 VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS------VWLLVREAPQVSIHTSSQ 616
Query: 260 -VTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGN 318
+ G+ ++C+ G P I W R L ++ G +L I V GN
Sbjct: 617 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGN 673
Query: 319 YTCHAS---GHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y+C A+ G +Q +T L PP + G A L C A G+P PR+ W
Sbjct: 674 YSCQATNEVGTDQ--ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 731
Query: 376 KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ G+++ ++ +L I + + D G YTC A NE+G
Sbjct: 732 RGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELG 771
Score = 38.5 bits (88), Expect = 0.026
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 10/175 (5%)
Query: 267 VLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGH 326
+++C+VH L + +R L + + G + S I + + G Y C A
Sbjct: 444 LVSCSVHSALPFRLQLRRGEARLG--EERHFQESG-NSSWEILRASKAEEGTYECTAVSR 500
Query: 327 EQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNG--VDVST 383
+ + V PP V + PG A L C G +TW+++ + ST
Sbjct: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
Query: 384 QMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTL 438
QL+ L+ L IS + D G Y C+A N GV L + ++ + ++
Sbjct: 561 GRVAQLADLS----LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 611
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 70.1 bits (170), Expect = 8e-12
Identities = 78/333 (23%), Positives = 129/333 (38%), Gaps = 25/333 (7%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS-LYITKVTTIHMG 317
T +G S L C G P + W ++G + + ++ F +D S L I KV
Sbjct: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
Query: 318 NYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y C A EQ H L+V P I A E +L C A G P+P ITW
Sbjct: 284 EYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
Query: 376 KNGVDVSTQMSKQLSLL-----ANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
+ ++S++ + A S L + S++Y D G Y C A N +G D L +
Sbjct: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
Query: 431 EDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEI-----QRHLKPTEKIFMS 485
+ + + ++ EG V VF+ + D ++ ++K S
Sbjct: 403 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 462
Query: 486 YEEICPQREKN-ATQPCQWVSAVNVRNRYIYVAQ------PALSRV----LVVDIQAQKV 534
Y E+ P E + C V+ + + + Q P++ +V +Q +
Sbjct: 463 YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 522
Query: 535 LQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKS 567
+ GV L K + ++VW W D ++
Sbjct: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 9/165 (5%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG-EDDSLYITKVTTIHMGNYTC 321
G V+ C V L P IIWK G + + +D+ ++ L I + G Y C
Sbjct: 132 GEDAVIVCDVVSSLPPTIIWKHKG--RDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
Query: 322 HA---SGHEQLFQTHVLQVNVPPVIRVYPE--SQAQEPGVAASLRCHAEGIPMPRITWLK 376
+ E F+ + VNVPP I+ + G + +L C AEG P P ++W K
Sbjct: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
Query: 377 NGVDVSTQMSKQLSLLA-NGSELHISSVRYEDTGAYTCIAKNEVG 420
+G + + + + + + S+L I V D Y CIA+N+ G
Sbjct: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG 294
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/173 (23%), Positives = 66/173 (38%), Gaps = 13/173 (7%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLED-------INDFGEDDSLYITK 310
T + + LTC GD P I W+ + T N E + SL +
Sbjct: 317 TAMELEEQVTLTCEASGDPIPSITWRTS--TRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
Query: 311 VTTIHMGNYTCHASGH-EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
+ G Y C AS Q Q+ L+V P ++ P + G ++ C P
Sbjct: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
Query: 370 PRITWLKNG--VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
I+W ++G + S + ++ + S L ++ D G Y C A N +G
Sbjct: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
Score = 38.1 bits (87), Expect = 0.034
Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 11/170 (6%)
Query: 260 VTVGLSTVLTCAVHGDLRPPII--WKRNG--LTLNFLDLEDINDFGEDDSLYITKVTTIH 315
++VG S C V GD + I + NG LT N + + + +L I
Sbjct: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
Query: 316 MGNYTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
G Y C +G + + V + + + P Q G A + C P I
Sbjct: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC----IAKNEV 419
W G DV + + +L+N + L I ++ D G Y C +A+ E+
Sbjct: 151 WKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILARGEI 199
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 70.1 bits (170), Expect = 8e-12
Identities = 78/333 (23%), Positives = 129/333 (38%), Gaps = 25/333 (7%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS-LYITKVTTIHMG 317
T +G S L C G P + W ++G + + ++ F +D S L I KV
Sbjct: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
Query: 318 NYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y C A EQ H L+V P I A E +L C A G P+P ITW
Sbjct: 284 EYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
Query: 376 KNGVDVSTQMSKQLSLL-----ANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFI 430
+ ++S++ + A S L + S++Y D G Y C A N +G D L +
Sbjct: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
Query: 431 EDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEI-----QRHLKPTEKIFMS 485
+ + + ++ EG V VF+ + D ++ ++K S
Sbjct: 403 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 462
Query: 486 YEEICPQREKN-ATQPCQWVSAVNVRNRYIYVAQ------PALSRV----LVVDIQAQKV 534
Y E+ P E + C V+ + + + Q P++ +V +Q +
Sbjct: 463 YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 522
Query: 535 LQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKS 567
+ GV L K + ++VW W D ++
Sbjct: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 9/165 (5%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG-EDDSLYITKVTTIHMGNYTC 321
G V+ C V L P IIWK G + + +D+ ++ L I + G Y C
Sbjct: 132 GEDAVIVCDVVSSLPPTIIWKHKG--RDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
Query: 322 HA---SGHEQLFQTHVLQVNVPPVIRVYPE--SQAQEPGVAASLRCHAEGIPMPRITWLK 376
+ E F+ + VNVPP I+ + G + +L C AEG P P ++W K
Sbjct: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
Query: 377 NGVDVSTQMSKQLSLLA-NGSELHISSVRYEDTGAYTCIAKNEVG 420
+G + + + + + + S+L I V D Y CIA+N+ G
Sbjct: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG 294
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/173 (23%), Positives = 66/173 (38%), Gaps = 13/173 (7%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLED-------INDFGEDDSLYITK 310
T + + LTC GD P I W+ + T N E + SL +
Sbjct: 317 TAMELEEQVTLTCEASGDPIPSITWRTS--TRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
Query: 311 VTTIHMGNYTCHASGH-EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPM 369
+ G Y C AS Q Q+ L+V P ++ P + G ++ C P
Sbjct: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
Query: 370 PRITWLKNG--VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
I+W ++G + S + ++ + S L ++ D G Y C A N +G
Sbjct: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
Score = 38.1 bits (87), Expect = 0.034
Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 11/170 (6%)
Query: 260 VTVGLSTVLTCAVHGDLRPPII--WKRNG--LTLNFLDLEDINDFGEDDSLYITKVTTIH 315
++VG S C V GD + I + NG LT N + + + +L I
Sbjct: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
Query: 316 MGNYTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
G Y C +G + + V + + + P Q G A + C P I
Sbjct: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC----IAKNEV 419
W G DV + + +L+N + L I ++ D G Y C +A+ E+
Sbjct: 151 WKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILARGEI 199
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/343 (23%), Positives = 132/343 (38%), Gaps = 35/343 (10%)
Query: 259 TVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDS-LYITKVTTIHMG 317
T +G S L C G P + W ++G + + ++ F +D S L I KV
Sbjct: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
Query: 318 NYTCHASGH--EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL 375
Y C A EQ H L+V P I A E +L C A G P+P ITW
Sbjct: 284 EYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
Query: 376 KNGVDVS-------TQMSKQLSL--------LANGSELHISSVRYEDTGAYTCIAKNEVG 420
+ ++S T+ KQ +L A S L + S++Y D G Y C A N +G
Sbjct: 343 TSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 402
Query: 421 VDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEI-----QRH 475
D L ++ + + ++ EG V VF+ + D ++ +
Sbjct: 403 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 462
Query: 476 LKPTEKIFMSYEEICPQREKN-ATQPCQWVSAVNVRNRYIYVAQ------PALSRV---- 524
+K SY E+ P E + C V+ + + + Q P++ +V
Sbjct: 463 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS 522
Query: 525 LVVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKS 567
+Q + + GV L K + ++VW W D ++
Sbjct: 523 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 565
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 9/165 (5%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFG-EDDSLYITKVTTIHMGNYTC 321
G V+ C V L P IIWK G + + +D+ ++ L I + G Y C
Sbjct: 132 GEDAVIVCDVVSSLPPTIIWKHKG--RDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
Query: 322 HA---SGHEQLFQTHVLQVNVPPVIRVYPE--SQAQEPGVAASLRCHAEGIPMPRITWLK 376
+ E F+ + VNVPP I+ + G + +L C AEG P P ++W K
Sbjct: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
Query: 377 NGVDVSTQMSKQLSLLA-NGSELHISSVRYEDTGAYTCIAKNEVG 420
+G + + + + + + S+L I V D Y CIA+N+ G
Sbjct: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG 294
Score = 38.9 bits (89), Expect = 0.020
Identities = 41/183 (22%), Positives = 66/183 (36%), Gaps = 23/183 (12%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLED-----------------INDF 300
T + + LTC GD P I W+ + T N E +
Sbjct: 317 TAMELEEQVTLTCEASGDPIPSITWRTS--TRNISSEEKASWTRPEKQETLDGHMVVRSH 374
Query: 301 GEDDSLYITKVTTIHMGNYTCHASGH-EQLFQTHVLQVNVPPVIRVYPESQAQEPGVAAS 359
SL + + G Y C AS Q Q+ L+V P ++ P + G +
Sbjct: 375 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVN 433
Query: 360 LRCHAEGIPMPRITWLKNG--VDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKN 417
+ C P I+W ++G + S + ++ + S L ++ D G Y C A N
Sbjct: 434 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 493
Query: 418 EVG 420
+G
Sbjct: 494 RIG 496
Score = 38.1 bits (87), Expect = 0.034
Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 11/170 (6%)
Query: 260 VTVGLSTVLTCAVHGDLRPPII--WKRNG--LTLNFLDLEDINDFGEDDSLYITKVTTIH 315
++VG S C V GD + I + NG LT N + + + +L I
Sbjct: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
Query: 316 MGNYTCHASGHEQLFQTHVLQVNV--PPVIRVYPESQAQEPGVAASLRCHAEGIPMPRIT 373
G Y C +G + + V + + + P Q G A + C P I
Sbjct: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTC----IAKNEV 419
W G DV + + +L+N + L I ++ D G Y C +A+ E+
Sbjct: 151 WKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILARGEI 199
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 4/131 (3%)
Query: 305 SLYITKVTTIHMGNYTCHAS-GHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRC 362
+L+ +VT GNYTC AS G + + HV L V V +V PE G A L+C
Sbjct: 424 TLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
Query: 363 HAEGIPMPRITWL-KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
A+G P P I W K+ + T++ ++ + NGS L I V ED+G YTCIA N +
Sbjct: 484 EAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGS-LVIHDVAPEDSGRYTCIAGNSCNI 542
Query: 422 DEDISSLFIED 432
+ L++ D
Sbjct: 543 KHTEAPLYVVD 553
Score = 47.4 bits (111), Expect = 6e-05
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 14/167 (8%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIH-MGNYTC 321
G +L C V + W +G + D E F + SL V + G + C
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQ--DTE--RRFAQGSSLSFAAVDRLQDSGTFQC 101
Query: 322 HA----SGHEQLFQT---HVLQVNVPPVIRVYPESQAQ-EPGVAASLRCHAEGIPMPRIT 373
A +G E ++ + PV+ +P S+A+ +P +LRCH +G P P
Sbjct: 102 VARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ 161
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
W ++G +S S ++ + L + E +G Y+C A + G
Sbjct: 162 WFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/151 (25%), Positives = 58/151 (38%), Gaps = 39/151 (25%)
Query: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSV-RY 405
P SQ G A LRC E + WL +G V + A GS L ++V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVI 465
+D+G + C+A+++V +E S+ NI W E G +++
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG-------------PVVLK 132
Query: 466 HPVD-------------CEIQRHLKPTEKIF 483
HP C I H +PT + F
Sbjct: 133 HPASEAEIQPQTQVTLRCHIDGHPRPTYQWF 163
Score = 36.6 bits (83), Expect = 0.100
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 14/122 (11%)
Query: 305 SLYITKVTTIHMGNYTCHASGHEQ----LFQT-HVLQVNVPPVIRVYPESQAQEPGVAAS 359
SL +T+V + G Y C G L T H+ ++ P+ E + G
Sbjct: 285 SLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLF----EPRVFTAGSEER 340
Query: 360 LRC-HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
+ C +G+P P + W GV + T + G EL ++++ D G YTC A N
Sbjct: 341 VTCLPPKGLPEPSVWWEHAGVRLPTHGR----VYQKGHELVLANIAESDAGVYTCHAANL 396
Query: 419 VG 420
G
Sbjct: 397 AG 398
Score = 35.0 bits (79), Expect = 0.29
Identities = 23/66 (34%), Positives = 29/66 (43%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
TTV G + +L C GD +P I WK L+ L ++ SL I V G
Sbjct: 471 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 530
Query: 318 NYTCHA 323
YTC A
Sbjct: 531 RYTCIA 536
Score = 30.4 bits (67), Expect = 7.2
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 6/58 (10%)
Query: 362 CHAEGIPMPRITWLKNGVDVSTQMSKQLS--LLANGSELHISSVRYEDTGAYTCIAKN 417
CHA + R + V+++ L + N LH + V +D G YTCIA N
Sbjct: 391 CHAANLAGQR----RQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 444
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
Length = 1030
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 4/131 (3%)
Query: 305 SLYITKVTTIHMGNYTCHAS-GHEQLFQTHV-LQVNVPPVIRVYPESQAQEPGVAASLRC 362
+L+ +VT GNYTC AS G + + HV L V V +V PE G A L+C
Sbjct: 514 TLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 573
Query: 363 HAEGIPMPRITWL-KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGV 421
A+G P P I W K+ + T++ ++ + NGS L I V ED+G YTCIA N +
Sbjct: 574 EAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGS-LVIHDVAPEDSGRYTCIAGNSCNI 632
Query: 422 DEDISSLFIED 432
+ L++ D
Sbjct: 633 KHTEAPLYVVD 643
Score = 47.4 bits (111), Expect = 6e-05
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 14/167 (8%)
Query: 263 GLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIH-MGNYTC 321
G +L C V + W +G + D E F + SL V + G + C
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQ--DTE--RRFAQGSSLSFAAVDRLQDSGTFQC 101
Query: 322 HA----SGHEQLFQT---HVLQVNVPPVIRVYPESQAQ-EPGVAASLRCHAEGIPMPRIT 373
A +G E ++ + PV+ +P S+A+ +P +LRCH +G P P
Sbjct: 102 VARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQ 161
Query: 374 WLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG 420
W ++G +S S ++ + L + E +G Y+C A + G
Sbjct: 162 WFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207
Score = 46.6 bits (109), Expect = 1e-04
Identities = 52/240 (21%), Positives = 98/240 (40%), Gaps = 20/240 (8%)
Query: 261 TVGLSTVLTCAVHGDL-RPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNY 319
T G +TC L P + W+ G+ L + + L + + G Y
Sbjct: 334 TAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG----RVYQKGHELVLANIAESDAGVY 389
Query: 320 TCHASG--HEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKN 377
TCHA+ ++ ++ VP ++ +SQ +E G L C + P P + W +N
Sbjct: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEE-GKPGYLDCLTQATPKPTVVWYRN 448
Query: 378 GVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKT 437
+ +S + + NG+ L I+SV D Y C++ G E + + + D +
Sbjct: 449 QMLISE--DSRFEVFKNGT-LRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
Query: 438 LANILWREEGLSVGNMFYVFSDDG----IIVIHPVDCEIQRHLKPTEKIFMSYEEICPQR 493
W + + V DD I + +I+ H++ T +F+++ ++ P+R
Sbjct: 506 ----EWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITF-KVEPER 560
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/151 (25%), Positives = 58/151 (38%), Gaps = 39/151 (25%)
Query: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSV-RY 405
P SQ G A LRC E + WL +G V + A GS L ++V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVI 465
+D+G + C+A+++V +E S+ NI W E G +++
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG-------------PVVLK 132
Query: 466 HPVD-------------CEIQRHLKPTEKIF 483
HP C I H +PT + F
Sbjct: 133 HPASEAEIQPQTQVTLRCHIDGHPRPTYQWF 163
Score = 36.6 bits (83), Expect = 0.100
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 14/122 (11%)
Query: 305 SLYITKVTTIHMGNYTCHASGHEQ----LFQT-HVLQVNVPPVIRVYPESQAQEPGVAAS 359
SL +T+V + G Y C G L T H+ ++ P+ E + G
Sbjct: 285 SLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLF----EPRVFTAGSEER 340
Query: 360 LRC-HAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNE 418
+ C +G+P P + W GV + T + G EL ++++ D G YTC A N
Sbjct: 341 VTCLPPKGLPEPSVWWEHAGVRLPTHGR----VYQKGHELVLANIAESDAGVYTCHAANL 396
Query: 419 VG 420
G
Sbjct: 397 AG 398
Score = 35.0 bits (79), Expect = 0.29
Identities = 23/66 (34%), Positives = 29/66 (43%)
Query: 258 TTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMG 317
TTV G + +L C GD +P I WK L+ L ++ SL I V G
Sbjct: 561 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
Query: 318 NYTCHA 323
YTC A
Sbjct: 621 RYTCIA 626
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,155,258
Number of Sequences: 37866
Number of extensions: 1587429
Number of successful extensions: 7106
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 4097
Number of HSP's gapped (non-prelim): 1939
length of query: 842
length of database: 18,247,518
effective HSP length: 111
effective length of query: 731
effective length of database: 14,044,392
effective search space: 10266450552
effective search space used: 10266450552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.