Search of human proteins with 5454104

Search of human proteins with 5454104

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5454104 transcriptional adaptor 3-like isoform a [Homo
sapiens]
         (432 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5454104 transcriptional adaptor 3-like isoform a [Homo sapiens]    866   0.0  
gi|19743894 transcriptional adaptor 3-like isoform b [Homo sapiens]   746   0.0  
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       44   3e-04
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                43   6e-04
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         42   8e-04
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    42   0.001
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     41   0.002
gi|116174778 centrosome spindle pole associated protein 1 isofor...    40   0.003
gi|116174789 centrosome spindle pole associated protein 1 isofor...    40   0.003
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    40   0.004
gi|148746195 trichohyalin [Homo sapiens]                               40   0.004
gi|21361517 UBX domain protein 1 [Homo sapiens]                        40   0.004
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 40   0.005
gi|118498345 AT-binding transcription factor 1 [Homo sapiens]          40   0.005
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]        39   0.007
gi|5453682 hexamethylene bis-acetamide inducible 1 [Homo sapiens]      39   0.007
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            39   0.009
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]        38   0.016
gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo...    38   0.016
gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo...    38   0.016
gi|4504063 golgin 97 [Homo sapiens]                                    38   0.020
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]              37   0.027
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa...    37   0.027
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap...    37   0.027
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]        37   0.035
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]        37   0.035
gi|110347443 TATA element modulatory factor 1 [Homo sapiens]           37   0.035
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    37   0.035
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    37   0.035
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    37   0.035

>gi|5454104 transcriptional adaptor 3-like isoform a [Homo sapiens]
          Length = 432

 Score =  866 bits (2238), Expect = 0.0
 Identities = 432/432 (100%), Positives = 432/432 (100%)

Query: 1   MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR 60
           MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR
Sbjct: 1   MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR 60

Query: 61  LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR 120
           LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR
Sbjct: 61  LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR 120

Query: 121 PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP 180
           PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP
Sbjct: 121 PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP 180

Query: 181 EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL 240
           EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL
Sbjct: 181 EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL 240

Query: 241 LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300
           LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR
Sbjct: 241 LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300

Query: 301 NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN 360
           NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN
Sbjct: 301 NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN 360

Query: 361 RTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTL 420
           RTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTL
Sbjct: 361 RTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTL 420

Query: 421 KERESILKLLDG 432
           KERESILKLLDG
Sbjct: 421 KERESILKLLDG 432


>gi|19743894 transcriptional adaptor 3-like isoform b [Homo sapiens]
          Length = 369

 Score =  746 bits (1927), Expect = 0.0
 Identities = 369/369 (100%), Positives = 369/369 (100%)

Query: 1   MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR 60
           MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR
Sbjct: 1   MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR 60

Query: 61  LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR 120
           LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR
Sbjct: 61  LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR 120

Query: 121 PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP 180
           PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP
Sbjct: 121 PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP 180

Query: 181 EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL 240
           EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL
Sbjct: 181 EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL 240

Query: 241 LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300
           LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR
Sbjct: 241 LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300

Query: 301 NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN 360
           NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN
Sbjct: 301 NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN 360

Query: 361 RTKKHDLLR 369
           RTKKHDLLR
Sbjct: 361 RTKKHDLLR 369


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 39/228 (17%), Positives = 91/228 (39%), Gaps = 35/228 (15%)

Query: 233 DTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGA 292
           D +D +   K+ + + E+ E+    G++ +  ++ +VEE      E++ +  +   +  +
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235

Query: 293 DGASTSPRNQNKPFSVPHTKSLESRIKEELIAQ------------------------GLL 328
           +        +     + H + +E   KE   A+                          +
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295

Query: 329 ESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTK--------KHDLLRLAKEEVSRQEL 380
           E+E++ A    +   AE R+R  E +  +A  R +          +  R+ +EE    E 
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355

Query: 381 RQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILK 428
           RQR++  +    +  ++  A  ++K    K E+ +  K L+E++  ++
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEK---AKVEEQKRNKQLEEKKHAMQ 400


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 73/333 (21%), Positives = 129/333 (38%), Gaps = 64/333 (19%)

Query: 155  WASVEPYCADITSEEVRTLEELLKPPEDEAEHY--KIPPLGKHYSQRWAQEDLLEEQKDG 212
            W  +E   A + S+  R  EELL   E E E    +I  L     Q+   E LL  + + 
Sbjct: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAAL-----QQERDEGLLLAESEK 1060

Query: 213  ARAAAVADKKKG-----LMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRL--L 265
             +A ++ + +K      LMG    L T  ++   +K +AQ  Q +D     ALT  L  L
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120

Query: 266  QALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELI-- 323
            +A  EE   +  ++        ++ G    S     +     +   +     ++ EL+  
Sbjct: 1121 RAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA 1180

Query: 324  AQGLLESED-----------------------RPAEDSEDEVLAELRKRQAELKALSAHN 360
             + L ES++                            S +E+ + ++K ++E  +L   N
Sbjct: 1181 QRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLAN 1240

Query: 361  RTKKHDL----------------LRLAKEEVSR---------QELRQRVRMADNEVMDAF 395
              K+  L                LR   +EV R         QELR++++M D+E     
Sbjct: 1241 EDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300

Query: 396  RKIMAARQKKRTPTKKEKDQAWKTLKERESILK 428
            R++   + +     + EK+   +TL  R+ +LK
Sbjct: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLK 1333



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 30/108 (27%), Positives = 59/108 (54%), Gaps = 2/108 (1%)

Query: 321 ELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQEL 380
           E +AQ  L+     A+  E++   + R+RQAE +A  A    ++ + LRL ++EV+RQ L
Sbjct: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRL-EQEVARQGL 804

Query: 381 RQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILK 428
              +R+A+ +  +A  + +   + +R+  +++  Q  + L  RE  L+
Sbjct: 805 EGSLRVAE-QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 27/120 (22%), Positives = 58/120 (48%), Gaps = 13/120 (10%)

Query: 317  RIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVS 376
            R+++E +   L E + + A+     + A   + +AE +AL     T   +L  L ++ ++
Sbjct: 903  RLEKEALEGSLFEVQRQLAQ-----LEARREQLEAEGQALLLAKETLTGELAGLRQQIIA 957

Query: 377  RQE--------LRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILK 428
             QE        + Q++  A+ E   + R+  AA ++     ++EK+ AW+ L+   + L+
Sbjct: 958  TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ 1017


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 51/237 (21%), Positives = 96/237 (40%), Gaps = 16/237 (6%)

Query: 192 LGKHYSQRWAQEDLLEEQKDGARAAAVADK------KKGLMGPLTELDTKDVDALLKKSE 245
           L  + +Q  A+ ++LE ++    A  +A++      K+ L   +T+L +   +    K E
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE 484

Query: 246 AQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMS--GKESGADGASTSPRNQN 303
            +      G    A    L   L   N     +D  +  +    KE  A  A T  + + 
Sbjct: 485 LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQ 544

Query: 304 KPFSVPH-TKSLESRIKE-ELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNR 361
               + H  + L S +K+ E   + + E ++   +D   ++     +R+A L+   A  +
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604

Query: 362 TKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRK--IMAARQKKRTPTKKEKDQA 416
                L  L KE+ ++ E+ Q+     NE  D+ +     A R+K     K E+ QA
Sbjct: 605 ----QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 48/229 (20%), Positives = 99/229 (43%), Gaps = 20/229 (8%)

Query: 203  EDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQ 262
            +D L   +D     A+ +++ GL+  L EL+  ++   L+++E      E         Q
Sbjct: 1662 DDALRSNEDLKEQLAIVERRNGLL--LEELE--EMKVALEQTERTRRLSE---------Q 1708

Query: 263  RLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEEL 322
             LL A     ++     S I   + K+  AD A      +N   S+  +++ E + K+ +
Sbjct: 1709 ELLDASDRVQLLHSQNTSLIN--TKKKLEADIAQCQAEVEN---SIQESRNAEEKAKKAI 1763

Query: 323  IAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQ 382
                ++  E +  +D+   +  E  K+  E       +R  + + L L   +   Q+L  
Sbjct: 1764 TDAAMMAEELKKEQDTSAHL--ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEN 1821

Query: 383  RVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLD 431
            RVR  +NE+    ++   A +      +K K+  ++  ++ ++IL+L D
Sbjct: 1822 RVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQD 1870



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 44/209 (21%), Positives = 83/209 (39%), Gaps = 31/209 (14%)

Query: 241  LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300
            L +SEA+ ++         L ++++  L E+N +     S   ++   E   +G   S  
Sbjct: 867  LARSEARRKE---------LEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS-- 915

Query: 301  NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAED-------SEDEVLAELRKRQAE- 352
               K       K L  R++EE      L ++ R  ED         D++   L K + E 
Sbjct: 916  ---KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEK 972

Query: 353  ------LKALSAHNRTKKHDLLRLAKEEVSRQELRQRV---RMADNEVMDAFRKIMAARQ 403
                  +K LS      + ++ +L KE+ S QE  Q+       + + ++   KI A  +
Sbjct: 973  HATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLE 1032

Query: 404  KKRTPTKKEKDQAWKTLKERESILKLLDG 432
            ++    +   +Q  K   + E   + L+G
Sbjct: 1033 QQTDDLEGSLEQEKKLRADLERAKRKLEG 1061


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 55/248 (22%), Positives = 111/248 (44%), Gaps = 28/248 (11%)

Query: 171  RTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLT 230
            R LEE +   E +AE   +  L K +  R   EDL+  + D  ++    +K K  +    
Sbjct: 1483 RALEEAM---EQKAE---LERLNKQF--RTEMEDLMSSKDDVGKSVHELEKSKRAL---- 1530

Query: 231  ELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMS-GKE 289
            E   +++   L++ E + +  ED      +  + ++A  E ++    E S        ++
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590

Query: 290  SGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKR 349
                 A      + +  +V   K LE  +K+       LE+    A  + DE + +LRK 
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKD-------LEAHIDSANKNRDEAIKQLRKL 1643

Query: 350  QAELKALSAHNRTKKHDLLRLAKEEVSRQ--ELRQRVRMADNEVMDAFRKIMAARQKKRT 407
            QA++K     +  ++ D  R ++EE+  Q  E  ++++  + E++    ++ AA + KR 
Sbjct: 1644 QAQMK-----DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR- 1697

Query: 408  PTKKEKDQ 415
              ++E+D+
Sbjct: 1698 QAQQERDE 1705



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 29/123 (23%), Positives = 62/123 (50%), Gaps = 14/123 (11%)

Query: 284  DMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVL 343
            D+   E+  D A     N+N+  ++   + L++++K+      + E +D  A  S +E+L
Sbjct: 1618 DLKDLEAHIDSA-----NKNRDEAIKQLRKLQAQMKD-----CMRELDDTRA--SREEIL 1665

Query: 344  AELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQ 403
            A+ ++ + +LK++ A     + +L   A E   RQ  ++R  +AD     + +  +A  +
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELA--AAERAKRQAQQERDELADEIANSSGKGALALEE 1723

Query: 404  KKR 406
            K+R
Sbjct: 1724 KRR 1726



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 69/312 (22%), Positives = 132/312 (42%), Gaps = 36/312 (11%)

Query: 126  LQPKIQEYEFTDDPIDVPRIPKND--APNRFWASVEPYCADITSEEVRTLEELLKPPE-- 181
            LQ   QE E      ++ ++ +    A NR    +E   + + +E+++  E+L    E  
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRL-TEMETLQSQLMAEKLQLQEQLQAETELC 896

Query: 182  DEAEHYKIPPLGKHYSQRWAQEDL---LEEQKDGARAAAVADKKKGLMGPLTELDTKDVD 238
             EAE  +     K         DL   +EE+++  R   +  +KK +   + EL+ +  +
Sbjct: 897  AEAEELRARLTAKKQELEEICHDLEARVEEEEE--RCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 239  ALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTS 298
                + + Q E+          T+  L+ L EE II  +ED        K+   D  +  
Sbjct: 955  EESARQKLQLEK--------VTTEAKLKKLEEEQII--LEDQNCKLAKEKKLLEDRIAEF 1004

Query: 299  PRN----QNKPFSVPHTKS--------LESRIKEELIAQGLLESEDRPAE-DSED--EVL 343
              N    + K  S+   K+        LE R++ E   +  LE   R  E DS D  + +
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064

Query: 344  AELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELR-QRVRMADNEVMDAFRKIMAAR 402
            AEL+ + AELK   A    +    L   +EE +++ +  +++R  ++++ +    + + R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124

Query: 403  QKKRTPTKKEKD 414
              +    K+++D
Sbjct: 1125 ASRNKAEKQKRD 1136



 Score = 29.3 bits (64), Expect = 7.3
 Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 8/121 (6%)

Query: 315 ESRIKEELIAQGLLESEDRPAED---SEDEVLAELRKRQAELKALSAHNRTKKHDLLRLA 371
           E+R+ E    Q  L +E    ++   +E E+ AE  + +A L A         HDL    
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924

Query: 372 KEEVSR----QELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESIL 427
           +EE  R    Q  +++++    E+ +   +  +ARQK +   K   +   K L+E + IL
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL-EKVTTEAKLKKLEEEQIIL 983

Query: 428 K 428
           +
Sbjct: 984 E 984



 Score = 29.3 bits (64), Expect = 7.3
 Identities = 24/116 (20%), Positives = 58/116 (50%), Gaps = 6/116 (5%)

Query: 314  LESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKE 373
            LE+R++EE      L++E +  + +  E+  +L + ++  + L     T +  L +L +E
Sbjct: 920  LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979

Query: 374  EVSRQE----LRQRVRMADNEVMDAFRKIMAARQKKRTPTK-KEKDQAWKT-LKER 423
            ++  ++    L +  ++ ++ + +    +    +K ++  K K K +A  T L+ER
Sbjct: 980  QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER 1035


>gi|116174778 centrosome spindle pole associated protein 1 isoform b
           [Homo sapiens]
          Length = 1221

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 56/279 (20%), Positives = 107/279 (38%), Gaps = 25/279 (8%)

Query: 132 EYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPP 191
           E + T D +    +   D P     S++ Y  +   +++R  EE  K   +E E Y+   
Sbjct: 568 ELKITSDQVINSGLIFEDKPKPSKQSLQSY-QEALQQQIREREERRKKEREEKEEYE--- 623

Query: 192 LGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQP 251
                ++  A+         G   A + D K  L+  L  +  +++DA        +E  
Sbjct: 624 -----AKLEAEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYED- 677

Query: 252 EDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHT 311
                     +R + +L      S  E+  + D + K SG     +SP  +   F  P T
Sbjct: 678 ----------KRAVVSLDPNLATSNAEN--LEDAANKSSGHMQTQSSPFARGNVFGEPPT 725

Query: 312 KSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLA 371
              E +IK++ + +  L  +    +  E+     LR  + + +   A  R +        
Sbjct: 726 ---ELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEE 782

Query: 372 KEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTK 410
           +E+   +E  QR++  ++  +   R+  A R+KK    K
Sbjct: 783 QEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEK 821


>gi|116174789 centrosome spindle pole associated protein 1 isoform a
           [Homo sapiens]
          Length = 1256

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 56/279 (20%), Positives = 107/279 (38%), Gaps = 25/279 (8%)

Query: 132 EYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPP 191
           E + T D +    +   D P     S++ Y  +   +++R  EE  K   +E E Y+   
Sbjct: 603 ELKITSDQVINSGLIFEDKPKPSKQSLQSY-QEALQQQIREREERRKKEREEKEEYE--- 658

Query: 192 LGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQP 251
                ++  A+         G   A + D K  L+  L  +  +++DA        +E  
Sbjct: 659 -----AKLEAEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYED- 712

Query: 252 EDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHT 311
                     +R + +L      S  E+  + D + K SG     +SP  +   F  P T
Sbjct: 713 ----------KRAVVSLDPNLATSNAEN--LEDAANKSSGHMQTQSSPFARGNVFGEPPT 760

Query: 312 KSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLA 371
              E +IK++ + +  L  +    +  E+     LR  + + +   A  R +        
Sbjct: 761 ---ELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEE 817

Query: 372 KEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTK 410
           +E+   +E  QR++  ++  +   R+  A R+KK    K
Sbjct: 818 QEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEK 856


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 49/248 (19%), Positives = 111/248 (44%), Gaps = 28/248 (11%)

Query: 171  RTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLT 230
            R LEE L+  E+     K          R   EDL+  + D  +     +K K  +    
Sbjct: 1490 RALEEALEAKEEFERQNK--------QLRADMEDLMSSKDDVGKNVHELEKSKRAL---- 1537

Query: 231  ELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPD-MSGKE 289
            E   +++   L++ E + +  ED      +  + ++A  E ++ +  E +     +  K+
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597

Query: 290  SGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKR 349
                 A      + +  +V   K +E  +K+       LE++   A  + DEV+ +LRK 
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKD-------LEAQIEAANKARDEVIKQLRKL 1650

Query: 350  QAELKALSAHNRTKKHDLLRLAKEEVSRQ--ELRQRVRMADNEVMDAFRKIMAARQKKRT 407
            QA++K     +  ++ +  R +++E+  Q  E  ++++  + E++   ++ +A+ ++ R 
Sbjct: 1651 QAQMK-----DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ-LQEELASSERARR 1704

Query: 408  PTKKEKDQ 415
              ++E+D+
Sbjct: 1705 HAEQERDE 1712



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 63/242 (26%), Positives = 102/242 (42%), Gaps = 42/242 (17%)

Query: 199  RWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFG 258
            R  + +L +E+K   RA AVA KKK       E+D KD++A ++ +    ++        
Sbjct: 1599 RELEAELEDERKQ--RALAVASKKK------MEIDLKDLEAQIEAANKARDE-------- 1642

Query: 259  ALTQ-RLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESR 317
             + Q R LQA         M+D        + S  +  + S  ++ K       KSLE+ 
Sbjct: 1643 VIKQLRKLQA--------QMKDYQRELEEARASRDEIFAQSKESEKK------LKSLEAE 1688

Query: 318  I---KEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRL---A 371
            I   +EEL +    E   R AE   DE+  E+    +   AL    R  +  + +L    
Sbjct: 1689 ILQLQEELASS---ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745

Query: 372  KEEVSRQE-LRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLL 430
            +EE S  E L  R R    +V D     +AA +     +   + Q  +  KE ++ L+ L
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQV-DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804

Query: 431  DG 432
            +G
Sbjct: 1805 EG 1806



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 60/273 (21%), Positives = 116/273 (42%), Gaps = 48/273 (17%)

Query: 164  DITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADK-K 222
            ++ ++  + + EL K  E+E ++++            A E+L E+ +   R  A  +K K
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226

Query: 223  KGLMGPLTELDTKDVDALLK-----KSEAQHEQPEDGCPFGALTQRLLQALVEENIISPM 277
            +GL     E D K++   +K     K+E++H+            ++ L A V+E      
Sbjct: 1227 QGL-----ETDNKELACEVKVLQQVKAESEHK------------RKKLDAQVQELHAKVS 1269

Query: 278  EDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAED 337
            E        G     + A  + + QN+  +V       S + EE   +G+  ++D  + +
Sbjct: 1270 E--------GDRLRVELAEKASKLQNELDNV-------STLLEEAEKKGIKFAKDAASLE 1314

Query: 338  SEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRK 397
            S+ +   EL + +   K L+  +R +     +L +E+ S QE ++     + E      K
Sbjct: 1315 SQLQDTQELLQEETRQK-LNLSSRIR-----QLEEEKNSLQEQQEE----EEEARKNLEK 1364

Query: 398  IMAARQKKRTPTKKEKDQAWKTLKERESILKLL 430
             + A Q +   TKK+ D    T++  E   K L
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 2/109 (1%)

Query: 325 QGLLESEDRPAED--SEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQ 382
           Q LLE ++  AE   +E E+ AE  + +A L A         HDL    +EE  R ++ Q
Sbjct: 883 QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942

Query: 383 RVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLD 431
             +      +    + +   +  R   + EK  A   +K+ E  + LL+
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 51/233 (21%), Positives = 101/233 (43%), Gaps = 38/233 (16%)

Query: 174  EELLKPPEDEAE-HYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTEL 232
            EELLK  E + +   ++  + + + Q   ++++L EQ   A     A+ ++  M      
Sbjct: 859  EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ-AETELFAEAEE--MRARLAA 915

Query: 233  DTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGA 292
              ++++ +L   E++ E+ E+        ++ +QA +++          + +   +E GA
Sbjct: 916  KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD----------LEEQLDEEEGA 965

Query: 293  DGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLES-------EDRPAEDSEDEVLAE 345
                     Q         ++   +++EE++   LLE        E +  ED   E  ++
Sbjct: 966  --------RQKLQLEKVTAEAKIKKMEEEIL---LLEDQNSKFIKEKKLMEDRIAECSSQ 1014

Query: 346  LRKRQAELKALSAHNRTKKHDLL-----RLAKEEVSRQELRQRVRMADNEVMD 393
            L + + + K L A  R K+  ++     RL KEE +RQEL +  R  D E  D
Sbjct: 1015 LAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 30/128 (23%), Positives = 64/128 (50%), Gaps = 11/128 (8%)

Query: 300  RNQNKPFSVPHTKSLESRIKEELIAQG---LLESEDRPAEDSEDEVLAELRKRQAELKAL 356
            R Q +   + H +  + R +E+L+ +G    L  ++R  +  E+E   +LR+++ E K L
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE--QQLRRQERERKFL 1710

Query: 357  SAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQA 416
                + ++ +L R  +EE   ++LRQ          + +RKI+   Q +    ++E+ Q 
Sbjct: 1711 QEEQQLRRQELERKFREE---EQLRQETEQEQLRRQERYRKILEEEQLR---PEREEQQL 1764

Query: 417  WKTLKERE 424
             +  ++R+
Sbjct: 1765 RRQERDRK 1772



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 53/266 (19%), Positives = 110/266 (41%), Gaps = 13/266 (4%)

Query: 168 EEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMG 227
           E+    E+ LK  E+E    +   L + + +   +++L EE+++ AR    +   K    
Sbjct: 650 EQQERREQRLKREEEEERLEQ--RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707

Query: 228 PLTELDTKD--VDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDM 285
             +E D +   V +  +K E Q  + E           L     E       E+    D 
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767

Query: 286 SGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDR--PAEDSEDEVL 343
           + +    +    S R + +  + P  +    R   +L A+   + E R  P E+ +++  
Sbjct: 768 TWQWQAEE---KSERGRQRLSARPPLREQRER---QLRAEERQQREQRFLPEEEEKEQRR 821

Query: 344 AELRKRQAELKALSAHNRTKKHD-LLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAAR 402
            + R+R+ EL+ L    + ++ +   +L +EE   QE ++R R  +      +R  +   
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881

Query: 403 QKKRTPTKKEKDQAWKTLKERESILK 428
           +K+R  T   K    + L++ + +L+
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQ 907



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 30/131 (22%), Positives = 54/131 (41%), Gaps = 18/131 (13%)

Query: 319 KEELIAQGLLESEDRPAEDSED-------EVLAELRKRQAELKALSAHN----------- 360
           +E+   Q  LE  DR   D E        +   E R  + +L++   H            
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 361 RTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTL 420
           R +  +L R  +EE  +Q   ++ R+   E    +RK     +K+    ++E+ Q  + L
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271

Query: 421 KERESILKLLD 431
           +E E  L+ L+
Sbjct: 272 QEEEEQLRKLE 282



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 26/110 (23%), Positives = 56/110 (50%), Gaps = 7/110 (6%)

Query: 314 LESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKE 373
           LE R+K E + +  LE E+R  +  + E   E R++Q  LK+     R ++    +L +E
Sbjct: 598 LEQRLKREEVER--LEQEERREQRLKREEPEEERRQQL-LKSEEQEERRQQ----QLRRE 650

Query: 374 EVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKER 423
           +  R+E R +    +  +    ++     ++++   ++E++QA + +K R
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 23/102 (22%), Positives = 49/102 (48%), Gaps = 5/102 (4%)

Query: 331  EDRPAEDSEDEVLAE---LRKRQAELKALSAHNRTKKHD--LLRLAKEEVSRQELRQRVR 385
            +D+  +  E+++L E    R+RQ   K        ++ +  LLR  +E+  RQE  ++ R
Sbjct: 962  KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021

Query: 386  MADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESIL 427
              D    +  + +   R+K+R   ++ + +  + L++ E  L
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 51/200 (25%), Positives = 80/200 (40%), Gaps = 35/200 (17%)

Query: 243 KSEAQHEQPEDGCPFGALTQRLLQALVEENIISPME--DSPIPDMSGK-ESGADGASTSP 299
           K E + E+ E         +R  Q L EE      E   S IP    + ES AD      
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA----- 714

Query: 300 RNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDS-------EDEVLAELRKR-QA 351
             Q+K +S P  +  + R +E+   +   ESE +  E+        E+E   +   + QA
Sbjct: 715 -RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 352 ELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKK 411
           E K+     R      LR  +E   R E RQ+                  R+++  P ++
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQ------------------REQRFLPEEE 815

Query: 412 EKDQAWKTLKERESILKLLD 431
           EK+Q  +  +ERE  L+ L+
Sbjct: 816 EKEQRRRQRREREKELQFLE 835



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 29/126 (23%), Positives = 54/126 (42%), Gaps = 19/126 (15%)

Query: 315 ESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKH--------- 365
           E +++    AQ L E ED   ED E     E R+ Q     L    + ++H         
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896

Query: 366 -------DLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWK 418
                   LL+  +EE+ R+E  +R R    E    +R+    +Q++    ++E+++  +
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRR---QEQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 419 TLKERE 424
             +ER+
Sbjct: 954 QERERQ 959



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 27/114 (23%), Positives = 52/114 (45%), Gaps = 8/114 (7%)

Query: 315  ESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHD--LLRLAK 372
            E+R ++EL  Q   E E +  E+       E R+RQ   +        ++ +  LLR  +
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128

Query: 373  EEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESI 426
            E+  RQEL ++ R  + EV     +++     +  P K+ + +  +  +E E +
Sbjct: 1129 EKRRRQELERQYR-EEEEVQQEEEQLL-----REEPEKRRRQELERQYREEEEL 1176



 Score = 29.3 bits (64), Expect = 7.3
 Identities = 25/122 (20%), Positives = 57/122 (46%), Gaps = 6/122 (4%)

Query: 310  HTKSLESRIKEELIA-QGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLL 368
            HT   +  ++E+L   Q LL+ E+   +  E E   + R+++ E +        ++ + L
Sbjct: 887  HTLYAKPALQEQLRKEQQLLQEEEEELQREERE---KRRRQEQERQYREEEQLQQEEEQL 943

Query: 369  RLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKD--QAWKTLKERESI 426
               + E  R++ R+R    D ++     +++    +KR   ++EK   +  +  +E E +
Sbjct: 944  LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003

Query: 427  LK 428
            L+
Sbjct: 1004 LR 1005


>gi|21361517 UBX domain protein 1 [Homo sapiens]
          Length = 312

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 41/158 (25%), Positives = 70/158 (44%), Gaps = 22/158 (13%)

Query: 269 VEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLL 328
           V+E + +P+      + +  E G    S S   + KP      +  +++   EL+AQ   
Sbjct: 48  VDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQR 107

Query: 329 ESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMAD 388
           E E+R     E E L   R+R+ + + LSA  +  + D +R A EE  R++  +      
Sbjct: 108 EREER----EEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEE------ 157

Query: 389 NEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESI 426
                     +AARQ+ R   K E+D+A +  K   S+
Sbjct: 158 ----------LAARQRVR--EKIERDKAERAKKYGGSV 183


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 61/271 (22%), Positives = 114/271 (42%), Gaps = 60/271 (22%)

Query: 164 DITSEEVRTLEELLKPP---EDEAEH-------YKIPPLGKHYSQRWAQEDLLEEQKDGA 213
           ++ S++ + LEE L PP   E+ A+         + PP G      W + + L E    +
Sbjct: 458 ELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517

Query: 214 RAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENI 273
            +  ++ +++    P          A  +K + QH Q E+  P             +E  
Sbjct: 518 LSLQLSLQREQAPSP---------PAACEKGKEQHSQAEELGP------------GQEEA 556

Query: 274 ISPMED---SPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLES 330
             P E    SP P +S      +  ST P    +  S    K++     EE +AQ +LE 
Sbjct: 557 EDPEEKVAVSPTPPVS-----PEVRSTEPVAPPEQLSEAALKAM-----EEAVAQ-VLEQ 605

Query: 331 EDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRL-AKEEVSRQELRQRVRMADN 389
           + R   +S+ E + +LR++  +          ++ ++LRL  ++E S   LR+R++ A  
Sbjct: 606 DQRHLLESKQEKMQQLREKLCQ---------EEEEEILRLHQQKEQSLSSLRERLQKAIE 656

Query: 390 EVMDAFR-----KIMAARQKKRTPTKKEKDQ 415
           E     R     ++   R + ++ T+ ++DQ
Sbjct: 657 EEEARMREEESQRLSWLRAQVQSSTQADEDQ 687



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 62/264 (23%), Positives = 104/264 (39%), Gaps = 35/264 (13%)

Query: 177  LKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVA-DKKKGLMGPLTELDTK 235
            LK  E  A H ++    K ++        L E  D  +A  +  + +  L+   ++   K
Sbjct: 968  LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQK 1027

Query: 236  DVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGA 295
               +L  ++EAQ +Q             L +  VEEN  SP  +   PD+  +    D  
Sbjct: 1028 HFSSL--EAEAQKKQ-----------HLLREVTVEENNASPHFE---PDLHIE----DLR 1067

Query: 296  STSPRNQNKPFSVPHTKSLESRIKEELIAQGL--LESEDRPAEDSEDEVLAE----LRKR 349
             +   NQ K  S   ++S E    + L +  +  L S +  A  S  E L +    +R+R
Sbjct: 1068 KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR 1127

Query: 350  QAELKALSAHNRTKKHDLLRLAKE-------EVSRQELRQRVRMADNEVMDAFRKIMAAR 402
            Q  LKA   H R +      +AK+       E  R+ L +  R  D E+  A RK     
Sbjct: 1128 QTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHNLL 1186

Query: 403  QKKRTPTKKEKDQAWKTLKERESI 426
            +KK     + +   W+   +  ++
Sbjct: 1187 KKKEEKLNQLESSLWEEASDEGTL 1210


>gi|118498345 AT-binding transcription factor 1 [Homo sapiens]
          Length = 3703

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 43/176 (24%), Positives = 67/176 (38%), Gaps = 20/176 (11%)

Query: 227 GPLTELDTKDVDALLKKSEAQHEQPEDGC-------PFGALTQRLLQALVEENIISPMED 279
           G  + +  +  +AL   S A  EQP+ G          G LT  +L+  +    + P+  
Sbjct: 366 GKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLAS 425

Query: 280 SPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSE 339
           SP     GK+SGA             FS     + E   +EE   +   E E+   E+ E
Sbjct: 426 SPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEE 485

Query: 340 D-----------EVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRV 384
           +           E+  EL  R  E    +A + +KK   L L+ + +S   L   V
Sbjct: 486 EEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKD--LALSNQSISNSPLMPNV 539


>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
          Length = 285

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 55/248 (22%), Positives = 98/248 (39%), Gaps = 50/248 (20%)

Query: 194 KHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPED 253
           + Y +   +E  +EEQ++ A   A A           E +T++  A   + E + ++ ED
Sbjct: 9   EEYEEEEQEEAAVEEQEEAAEEDAEA-----------EAETEETRAEEDEEEEEAKEAED 57

Query: 254 GCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKS 313
           G                     PME+S     S   +        P  +   F   H K 
Sbjct: 58  G---------------------PMEESKPKPRSFMPNLVP--PKIPDGERVDFDDIHRKR 94

Query: 314 LESRIKEELIAQGLLESEDRPAEDSEDEVLA---ELRKRQAE-LKALSAHNRTKKHDLLR 369
           +E  + E    Q L+E+     +  E+E+++    + +R+AE  +     N  +K    R
Sbjct: 95  MEKDLNE---LQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNR 151

Query: 370 LAKEEVSRQELRQRVRMADNEV--------MDAFRKIMAARQKKRTPTKKEKDQAWKTLK 421
           LA+E   R+E   R R A++E         M  F   +   ++K    + E+++  K L 
Sbjct: 152 LAEERARREEEENR-RKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILA 210

Query: 422 ERESILKL 429
           ER  +L +
Sbjct: 211 ERRKVLAI 218


>gi|5453682 hexamethylene bis-acetamide inducible 1 [Homo sapiens]
          Length = 359

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 48/211 (22%), Positives = 85/211 (40%), Gaps = 25/211 (11%)

Query: 180 PEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDA 239
           P  +  H+K      +Y   W ++   +E K   RA+ +  +      P+   +T     
Sbjct: 157 PSKKKRHWK-----PYYKLTWEEKKKFDE-KQSLRASRIRAEMFAKGQPVAPYNTTQF-- 208

Query: 240 LLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSP 299
                   H+Q E     G  ++R      + +    ME+    D      G DG+    
Sbjct: 209 ----LMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQ 264

Query: 300 RNQNKPFSVPHTKSLESRIKEELIAQGL-LESEDRPAEDSEDEVLAE--------LRKRQ 350
           R+ ++ +   HT+SL++  K+ELI + L LE      ED  + +  E         R R+
Sbjct: 265 RDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRE 324

Query: 351 AELKALSAHNRTKKHDLLRLAKEEVSRQELR 381
            EL+     +R +  +L  L + E+ RQ+ R
Sbjct: 325 LELEL----DRLRAENLQLLTENELHRQQER 351


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 2/140 (1%)

Query: 287 GKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAEL 346
           GK+          R + K       +    R K+E   +   E  +R     E E     
Sbjct: 51  GKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110

Query: 347 RKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKR 406
            K + + K      RT K    R  KEE  R+E ++R R  +    +  RK    R++K+
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQ 170

Query: 407 TPTKKE--KDQAWKTLKERE 424
              K+E  K++  K  K+RE
Sbjct: 171 VGEKEEERKEKERKERKKRE 190



 Score = 32.7 bits (73), Expect = 0.66
 Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 13/122 (10%)

Query: 303 NKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRT 362
           +KP + P  +S E R +E  I       ++R +E  ++    E RKR+ E +      R 
Sbjct: 26  SKPCTQPGWQS-EIREREREIETRKEGKKERESERKKERREREKRKREREKER--KRERG 82

Query: 363 KKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKE 422
           KK       KEE  R++ R+     + E           ++K++   KKE+ +  K  KE
Sbjct: 83  KKEKKGERKKEERERKKRRREKENKEGE----------EKEKRKKKEKKERGRTSKEGKE 132

Query: 423 RE 424
           RE
Sbjct: 133 RE 134



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 30/118 (25%), Positives = 51/118 (43%), Gaps = 13/118 (11%)

Query: 315 ESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQA--------ELKALSAHNRTKKHD 366
           E   KEE   +   E E +  E  ++    E +KR+         E K      R K+  
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191

Query: 367 LLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERE 424
             +  K+E  R+E R+R +  + +  +  +K    RQK R    +EK++  +  KER+
Sbjct: 192 NRKERKKERERKERRERKK--ERKKKEERKK---ERQKDRQTNWREKERGKRERKERK 244


>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
          Length = 288

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 54/251 (21%), Positives = 98/251 (39%), Gaps = 53/251 (21%)

Query: 194 KHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPED 253
           + Y +   +E  +EEQ++ A   A A           E +T++  A   + E + ++ ED
Sbjct: 9   EEYEEEEQEEAAVEEQEEAAEEDAEA-----------EAETEETRAEEDEEEEEAKEAED 57

Query: 254 GCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKS 313
           G                     PME+S     S   +        P  +   F   H K 
Sbjct: 58  G---------------------PMEESKPKPRSFMPNLVP--PKIPDGERVDFDDIHRKR 94

Query: 314 LESRIKEELIAQGLLESEDRPAEDSEDEVLA---ELRKRQAE-LKALSAHNRTKKHDLLR 369
           +E  + E    Q L+E+     +  E+E+++    + +R+AE  +     N  +K    R
Sbjct: 95  MEKDLNE---LQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNR 151

Query: 370 LAKEEVSRQELRQRVRMADNEV-----------MDAFRKIMAARQKKRTPTKKEKDQAWK 418
           LA+E   R+E   R R A++E               + +  A  ++K    + E+++  K
Sbjct: 152 LAEERARREEEENR-RKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKK 210

Query: 419 TLKERESILKL 429
            L ER  +L +
Sbjct: 211 ILAERRKVLAI 221


>gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 26/128 (20%), Positives = 61/128 (47%), Gaps = 1/128 (0%)

Query: 299 PRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSA 358
           P  + KP S+    SL +  +++   +  + S++RP +D +     E+ K   + K    
Sbjct: 2   PAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLE 61

Query: 359 HNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWK 418
            ++ KK D  R  K+E  + +  +  +  + E     ++    +Q+++   ++E++ A +
Sbjct: 62  DDKRKKEDKERKKKDE-EKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQ 120

Query: 419 TLKERESI 426
             ++ ESI
Sbjct: 121 MKEKEESI 128



 Score = 32.3 bits (72), Expect = 0.86
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 282 IPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDE 341
           +P    K +  +   + P N+ K  S   T S + R K+++      E    P ED +  
Sbjct: 1   MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAP-EDKKKR 59

Query: 342 VLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAA 401
           +  + RK++ + +      + K  +  +  +EE  ++   +  +  + +      +  AA
Sbjct: 60  LEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAA 119

Query: 402 RQKKRTPTKKEKDQAWK 418
           + K++  + +   +AW+
Sbjct: 120 QMKEKEESIQLHQEAWE 136


>gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 26/128 (20%), Positives = 61/128 (47%), Gaps = 1/128 (0%)

Query: 299 PRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSA 358
           P  + KP S+    SL +  +++   +  + S++RP +D +     E+ K   + K    
Sbjct: 2   PAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLE 61

Query: 359 HNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWK 418
            ++ KK D  R  K+E  + +  +  +  + E     ++    +Q+++   ++E++ A +
Sbjct: 62  DDKRKKEDKERKKKDE-EKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQ 120

Query: 419 TLKERESI 426
             ++ ESI
Sbjct: 121 MKEKEESI 128



 Score = 32.3 bits (72), Expect = 0.86
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 282 IPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDE 341
           +P    K +  +   + P N+ K  S   T S + R K+++      E    P ED +  
Sbjct: 1   MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAP-EDKKKR 59

Query: 342 VLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAA 401
           +  + RK++ + +      + K  +  +  +EE  ++   +  +  + +      +  AA
Sbjct: 60  LEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAA 119

Query: 402 RQKKRTPTKKEKDQAWK 418
           + K++  + +   +AW+
Sbjct: 120 QMKEKEESIQLHQEAWE 136


>gi|4504063 golgin 97 [Homo sapiens]
          Length = 767

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 61/267 (22%), Positives = 119/267 (44%), Gaps = 33/267 (12%)

Query: 166 TSEEVRTLEELLKPPEDEAE-HYKIPPLGKHYSQRWAQEDLLEEQKDGA--RAAAVADKK 222
           T E  RT EEL+   +  ++   K+  L +HYS    Q D +   K GA  +  A+  K+
Sbjct: 206 TRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKE 265

Query: 223 KGLMGPLTELDTKDVDALLKKSEAQHEQPEDGC-----PFGALTQRLLQALV-EENIISP 276
           + L   + +L        L+K  A+ ++ ED          +L +RL Q L  EE++   
Sbjct: 266 QELQALIQQLSID-----LQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHVQEL 320

Query: 277 MEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAE 336
           +++  + + +  E        +  +Q K  +     +LE+R++E    +  L++ +   +
Sbjct: 321 LKEKTLAEQN-LEDTRQQLLAARSSQAKAIN-----TLETRVRE---LEQTLQASEEQLQ 371

Query: 337 DSEDEVLAELRKRQAELKALSAHNRTKKH-DLLRLAKEEVSRQELRQRVRMADNEVMDAF 395
            S+  V A+    + +++ L+A N+   H     LA E    Q+  +R +  + +++ A 
Sbjct: 372 QSKGIVAAQ----ETQIQELAAANQESSHVQQQALALE----QQFLERTQALEAQIV-AL 422

Query: 396 RKIMAARQKKRTPTKKEKDQAWKTLKE 422
            +  AA Q       ++ +Q    LKE
Sbjct: 423 ERTRAADQTTAEQGMRQLEQENAALKE 449


>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
          Length = 284

 Score = 37.4 bits (85), Expect = 0.027
 Identities = 63/265 (23%), Positives = 105/265 (39%), Gaps = 46/265 (17%)

Query: 168 EEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAA-VADKKKGLM 226
           EE + L++ LK  EDE E Y         S + AQE L + +K    A A VA   + + 
Sbjct: 41  EEQQALQKKLKGTEDEVEKYS-------ESVKEAQEKLEQAEKKATDAEADVASLNRRIQ 93

Query: 227 GPLTELDTKD---VDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIP 283
               ELD        AL K  EA+    E        ++R ++ ++E   +   E   + 
Sbjct: 94  LVEEELDRAQERLATALQKLEEAEKAADE--------SERGMK-VIENRAMKDEEKMELQ 144

Query: 284 DMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSED--- 340
           +M  KE+             K  +    +  E   ++ +I +G LE  +  AE +E    
Sbjct: 145 EMQLKEA-------------KHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRAR 191

Query: 341 EVLAELRKRQAELKALSAHNR--TKKHD--------LLRLAKEEVSRQELRQRVRMADNE 390
           ++  ELR     LK+L A     + K D        L    KE  +R E  +R      +
Sbjct: 192 QLEEELRTMDQALKSLMASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEK 251

Query: 391 VMDAFRKIMAARQKKRTPTKKEKDQ 415
            +D   + +A+ +++     +  DQ
Sbjct: 252 TIDDLEETLASAKEENVEIHQTLDQ 276


>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
           sapiens]
          Length = 1185

 Score = 37.4 bits (85), Expect = 0.027
 Identities = 55/268 (20%), Positives = 104/268 (38%), Gaps = 40/268 (14%)

Query: 169 EVRTLEELLKPPEDEAEHYK--IPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLM 226
           +V  L+E++     E    K  +  L  H ++       LEE  D AR   +  +     
Sbjct: 251 KVIELQEIISKQSREQSQMKERLASLSSHVTE-------LEEDLDTARKDLIKSE----- 298

Query: 227 GPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMS 286
               E++TK +   ++++ AQ E  E+      L +R L A  E   +  + D    +++
Sbjct: 299 ----EMNTK-LQRDVREAMAQKEDMEERIT--TLEKRYLAAQREATSVHDLNDKLENEIA 351

Query: 287 GKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQ-------------------GL 327
            K+S         R   +   +   K  ++  K E + +                   G 
Sbjct: 352 NKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGN 411

Query: 328 LESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMA 387
           +E   R  E   +E   EL++ +   K    HN+     + +L  E   R +L  + RMA
Sbjct: 412 IEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMA 471

Query: 388 DNEVMDAFRKIMAARQKKRTPTKKEKDQ 415
             E  ++  + + + +K+   T+ +KDQ
Sbjct: 472 ALEDKNSLLREVESAKKQLEETQHDKDQ 499


>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
           sapiens]
          Length = 1202

 Score = 37.4 bits (85), Expect = 0.027
 Identities = 55/268 (20%), Positives = 104/268 (38%), Gaps = 40/268 (14%)

Query: 169 EVRTLEELLKPPEDEAEHYK--IPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLM 226
           +V  L+E++     E    K  +  L  H ++       LEE  D AR   +  +     
Sbjct: 251 KVIELQEIISKQSREQSQMKERLASLSSHVTE-------LEEDLDTARKDLIKSE----- 298

Query: 227 GPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMS 286
               E++TK +   ++++ AQ E  E+      L +R L A  E   +  + D    +++
Sbjct: 299 ----EMNTK-LQRDVREAMAQKEDMEERIT--TLEKRYLAAQREATSVHDLNDKLENEIA 351

Query: 287 GKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQ-------------------GL 327
            K+S         R   +   +   K  ++  K E + +                   G 
Sbjct: 352 NKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGN 411

Query: 328 LESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMA 387
           +E   R  E   +E   EL++ +   K    HN+     + +L  E   R +L  + RMA
Sbjct: 412 IEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMA 471

Query: 388 DNEVMDAFRKIMAARQKKRTPTKKEKDQ 415
             E  ++  + + + +K+   T+ +KDQ
Sbjct: 472 ALEDKNSLLREVESAKKQLEETQHDKDQ 499


>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
          Length = 282

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 48/206 (23%), Positives = 84/206 (40%), Gaps = 22/206 (10%)

Query: 242 KKSEAQHEQPEDGCPFGALTQRL-LQALVEENIISPMEDSPIPDMSGKESGADGASTSPR 300
           ++ E Q E  E+     A T+    +   EE      ED P+ +   K          P+
Sbjct: 14  EEQEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPK 73

Query: 301 ---NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLA---ELRKRQAE-L 353
               +   F   H K +E  + E    Q L+E+     +  E+E+++    + +R+AE  
Sbjct: 74  IPDGERVDFDDIHRKRMEKDLNE---LQALIEAHFENRKKEEEELVSLKDRIERRRAERA 130

Query: 354 KALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEV--MDAFRKIM--------AARQ 403
           +     N  +K    RLA+E   R+E   R R A++E     A   +M        A  +
Sbjct: 131 EQQRIRNEREKERQNRLAEERARREEEENR-RKAEDEARKKKALSNMMHFGGYIQKAQTE 189

Query: 404 KKRTPTKKEKDQAWKTLKERESILKL 429
           +K    + E+++  K L ER  +L +
Sbjct: 190 RKSGKRQTEREKKKKILAERRKVLAI 215


>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
          Length = 295

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 51/245 (20%), Positives = 98/245 (40%), Gaps = 39/245 (15%)

Query: 203 EDLLEEQKDGARAAAVADKKKGLMGPLTELDT---KDVDALLKKSEAQHEQPEDGCPFGA 259
           E+++EE ++  +  A  ++++       E +    +D +A  +  E + E+ E       
Sbjct: 5   EEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDE------- 57

Query: 260 LTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR---NQNKPFSVPHTKSLES 316
                     EE      ED P+ +   K          P+    +   F   H K +E 
Sbjct: 58  ----------EEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEK 107

Query: 317 RIKEELIAQGLLESEDRPAEDSEDEVLA---ELRKRQAE-LKALSAHNRTKKHDLLRLAK 372
            + E    Q L+E+     +  E+E+++    + +R+AE  +     N  +K    RLA+
Sbjct: 108 DLNE---LQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 164

Query: 373 EEVSRQELRQRVRMADNEV--------MDAFRKIMAARQKKRTPTKKEKDQAWKTLKERE 424
           E   R+E   R R A++E         M  F   +   ++K    + E+++  K L ER 
Sbjct: 165 ERARREEEENR-RKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERR 223

Query: 425 SILKL 429
            +L +
Sbjct: 224 KVLAI 228


>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
          Length = 1093

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 41/163 (25%), Positives = 73/163 (44%), Gaps = 23/163 (14%)

Query: 269 VEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKP-FSVPHTKSLESRIKEELIAQGL 327
           V E ++ P E++ + +         G S +P N  +P   V  T   E +   + +A+  
Sbjct: 380 VNETLVIPTEEAEMEE--------SGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQC 431

Query: 328 LESEDRPAEDSEDEVLAE--------LRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQE 379
             +E +P   SE E + +        L KR+A+L +LS     K+  LL  A + +  + 
Sbjct: 432 EPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLS-----KEKALLEEAFDNLKDEM 486

Query: 380 LRQRVRMAD-NEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLK 421
            R +   +  + + D F + +A  +KK     KE+D A K +K
Sbjct: 487 FRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIK 529


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 58/257 (22%), Positives = 110/257 (42%), Gaps = 36/257 (14%)

Query: 202  QEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL---------LKKSEAQHEQPE 252
            + +L +E+K  A AAA    KK L G L +L+ +   A+         L+K +AQ +  +
Sbjct: 1602 ETELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658

Query: 253  DGCPFGALTQRLLQALVEEN----------IISPMEDSPIPDMSGKESGADGASTSPRNQ 302
                    ++  + A  +EN          ++   ED    + + K++  +    +    
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 303  NKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRT 362
            +   S  +    E R  E  IAQ  LE E    + + + +   +RK   + + LS    T
Sbjct: 1719 SS-LSGRNALQDEKRRLEARIAQ--LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775

Query: 363  KKHDLLR--LAKEEVSRQ--ELRQRVRMADNEVMDAFRKIMAARQKKRTPTK-------K 411
            ++    +   A++++ RQ  ELR ++   +  V   F+  +AA + K    +       +
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835

Query: 412  EKDQAWKTLKERESILK 428
            EK  A K+LK+++  LK
Sbjct: 1836 EKQAATKSLKQKDKKLK 1852



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 60/269 (22%), Positives = 111/269 (41%), Gaps = 41/269 (15%)

Query: 169  EVRTLEELLKPPEDEAEHYK---------IPPLGKHYSQRWAQEDLLEEQKDGARAAAVA 219
            +V   EE ++  EDE +  K         +  L + +SQ   +++LL+EQ   A     A
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 904

Query: 220  DKKKGLMGPLTELDTKDVDALLKKSEAQHEQPED-GCPFGALTQRLLQALVEENIISPME 278
            + ++  M        ++++ +L + EA+ E+ ED G    A  +++ Q +++  +   +E
Sbjct: 905  EAEE--MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLE 960

Query: 279  DSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDS 338
            +             + A+       K  +    K LE  I         L  E +  E+ 
Sbjct: 961  E-------------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007

Query: 339  EDEVLAELRKRQAELKALSAHNRTKKHDLL------RLAKEEVSRQELRQRVRMADNEVM 392
              ++   L + + + K L+      KH+ +      RL KEE SRQEL +  R  + +  
Sbjct: 1008 ISDLTTNLAEEEEKAKNLT--KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 393  DAFRKI-----MAARQKKRTPTKKEKDQA 416
            D   +I       A  K +   K+E+ QA
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQA 1094


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 58/257 (22%), Positives = 110/257 (42%), Gaps = 36/257 (14%)

Query: 202  QEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL---------LKKSEAQHEQPE 252
            + +L +E+K  A AAA    KK L G L +L+ +   A+         L+K +AQ +  +
Sbjct: 1609 ETELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 253  DGCPFGALTQRLLQALVEEN----------IISPMEDSPIPDMSGKESGADGASTSPRNQ 302
                    ++  + A  +EN          ++   ED    + + K++  +    +    
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 303  NKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRT 362
            +   S  +    E R  E  IAQ  LE E    + + + +   +RK   + + LS    T
Sbjct: 1726 SS-LSGRNALQDEKRRLEARIAQ--LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 363  KKHDLLR--LAKEEVSRQ--ELRQRVRMADNEVMDAFRKIMAARQKKRTPTK-------K 411
            ++    +   A++++ RQ  ELR ++   +  V   F+  +AA + K    +       +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842

Query: 412  EKDQAWKTLKERESILK 428
            EK  A K+LK+++  LK
Sbjct: 1843 EKQAATKSLKQKDKKLK 1859



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 60/269 (22%), Positives = 111/269 (41%), Gaps = 41/269 (15%)

Query: 169  EVRTLEELLKPPEDEAEHYK---------IPPLGKHYSQRWAQEDLLEEQKDGARAAAVA 219
            +V   EE ++  EDE +  K         +  L + +SQ   +++LL+EQ   A     A
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 911

Query: 220  DKKKGLMGPLTELDTKDVDALLKKSEAQHEQPED-GCPFGALTQRLLQALVEENIISPME 278
            + ++  M        ++++ +L + EA+ E+ ED G    A  +++ Q +++  +   +E
Sbjct: 912  EAEE--MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLE 967

Query: 279  DSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDS 338
            +             + A+       K  +    K LE  I         L  E +  E+ 
Sbjct: 968  E-------------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 339  EDEVLAELRKRQAELKALSAHNRTKKHDLL------RLAKEEVSRQELRQRVRMADNEVM 392
              ++   L + + + K L+      KH+ +      RL KEE SRQEL +  R  + +  
Sbjct: 1015 ISDLTTNLAEEEEKAKNLT--KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 393  DAFRKI-----MAARQKKRTPTKKEKDQA 416
            D   +I       A  K +   K+E+ QA
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQA 1101


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 37.0 bits (84), Expect = 0.035
 Identities = 58/257 (22%), Positives = 110/257 (42%), Gaps = 36/257 (14%)

Query: 202  QEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL---------LKKSEAQHEQPE 252
            + +L +E+K  A AAA    KK L G L +L+ +   A+         L+K +AQ +  +
Sbjct: 1609 ETELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 253  DGCPFGALTQRLLQALVEEN----------IISPMEDSPIPDMSGKESGADGASTSPRNQ 302
                    ++  + A  +EN          ++   ED    + + K++  +    +    
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 303  NKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRT 362
            +   S  +    E R  E  IAQ  LE E    + + + +   +RK   + + LS    T
Sbjct: 1726 SS-LSGRNALQDEKRRLEARIAQ--LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 363  KKHDLLR--LAKEEVSRQ--ELRQRVRMADNEVMDAFRKIMAARQKKRTPTK-------K 411
            ++    +   A++++ RQ  ELR ++   +  V   F+  +AA + K    +       +
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842

Query: 412  EKDQAWKTLKERESILK 428
            EK  A K+LK+++  LK
Sbjct: 1843 EKQAATKSLKQKDKKLK 1859



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 60/269 (22%), Positives = 111/269 (41%), Gaps = 41/269 (15%)

Query: 169  EVRTLEELLKPPEDEAEHYK---------IPPLGKHYSQRWAQEDLLEEQKDGARAAAVA 219
            +V   EE ++  EDE +  K         +  L + +SQ   +++LL+EQ   A     A
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYA 911

Query: 220  DKKKGLMGPLTELDTKDVDALLKKSEAQHEQPED-GCPFGALTQRLLQALVEENIISPME 278
            + ++  M        ++++ +L + EA+ E+ ED G    A  +++ Q +++  +   +E
Sbjct: 912  EAEE--MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLE 967

Query: 279  DSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDS 338
            +             + A+       K  +    K LE  I         L  E +  E+ 
Sbjct: 968  E-------------EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014

Query: 339  EDEVLAELRKRQAELKALSAHNRTKKHDLL------RLAKEEVSRQELRQRVRMADNEVM 392
              ++   L + + + K L+      KH+ +      RL KEE SRQEL +  R  + +  
Sbjct: 1015 ISDLTTNLAEEEEKAKNLT--KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 393  DAFRKI-----MAARQKKRTPTKKEKDQA 416
            D   +I       A  K +   K+E+ QA
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQA 1101


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,642,674
Number of Sequences: 37866
Number of extensions: 995602
Number of successful extensions: 5327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 276
Number of HSP's that attempted gapping in prelim test: 4778
Number of HSP's gapped (non-prelim): 781
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.