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Search of human proteins with 5453978
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453978 protein kinase, cGMP-dependent, type II [Homo
sapiens]
(762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 1539 0.0
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 676 0.0
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 670 0.0
gi|4826948 protein kinase, X-linked [Homo sapiens] 285 1e-76
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 282 7e-76
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 282 7e-76
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 278 2e-74
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 271 2e-72
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 270 5e-72
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 222 1e-57
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 222 1e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 220 3e-57
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 218 2e-56
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 217 3e-56
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 217 3e-56
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 213 7e-55
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 212 9e-55
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 212 1e-54
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 212 1e-54
gi|5453974 protein kinase N2 [Homo sapiens] 211 2e-54
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 209 6e-54
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 202 9e-52
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 202 9e-52
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 202 9e-52
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 202 9e-52
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 202 9e-52
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 202 9e-52
gi|40254851 protein kinase PKNbeta [Homo sapiens] 201 3e-51
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 200 4e-51
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 200 4e-51
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 1539 bits (3985), Expect = 0.0
Identities = 762/762 (100%), Positives = 762/762 (100%)
Query: 1 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 60
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK
Sbjct: 1 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 60
Query: 61 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 120
QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG
Sbjct: 61 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 120
Query: 121 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 180
AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM
Sbjct: 121 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 180
Query: 181 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 240
VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC
Sbjct: 181 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 240
Query: 241 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 300
TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID
Sbjct: 241 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 300
Query: 301 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 360
CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL
Sbjct: 301 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 360
Query: 361 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 420
ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS
Sbjct: 361 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 420
Query: 421 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 480
MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA
Sbjct: 421 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 480
Query: 481 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 540
MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS
Sbjct: 481 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 540
Query: 541 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 600
ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK
Sbjct: 541 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 600
Query: 601 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 660
IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN
Sbjct: 601 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 660
Query: 661 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 720
LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK
Sbjct: 661 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 720
Query: 721 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762
ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
Sbjct: 721 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 676 bits (1743), Expect = 0.0
Identities = 354/733 (48%), Positives = 478/733 (65%), Gaps = 54/733 (7%)
Query: 32 ELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGG 91
+L+ L+ K E+++R+ + EL +L ++ I +L EL + Q
Sbjct: 6 DLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSA 65
Query: 92 SPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRK 151
S LQ P R + +SAEPT +D+ + K
Sbjct: 66 STLQGEP--------------------RTKRQAISAEPTA--FDIQDLSHVTLPF--YPK 101
Query: 152 DSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEG 211
K LI +A+ N F+K L+ QI+++V+CMY Y + S IIK+G+ G+ ++V+ +G
Sbjct: 102 SPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDG 161
Query: 212 RLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQ 271
++EV + L ++ FGELAILYNCTRTA+VK + NVK WA+DR+ FQ IM RT
Sbjct: 162 KVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGL 221
Query: 272 ARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKV 331
+ +Y FL+SV ++LPE+ L+K+ D LE +Y+ G+YIIR+G G TFFI++KG V
Sbjct: 222 IKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTV 281
Query: 332 KVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 391
VT+ + P ++TL KG++FGEKAL +DVR+AN+IA E V CLVIDR++F +
Sbjct: 282 NVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLI 340
Query: 392 GTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQ 451
G ++ V+N +D + AK E A F ++
Sbjct: 341 GGLDD--------VSNKAYEDAEAKAKY-------------------EAEAAFFANLKLS 373
Query: 452 NLEIIATLGVGGFGRVELVKVKNE-NVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
+ II TLGVGGFGRVELV++K+E + FAMK ++K+HIVDT+QQEH+ SEK+I++ S
Sbjct: 374 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 433
Query: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570
FIV+LYRTFKD+KY+YML+EACLGGELW+ILRDRGSF++ T++F ACV EAF YLH
Sbjct: 434 DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSK 493
Query: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 630
GIIYRDLKPENLILD GY KLVDFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKGHD S
Sbjct: 494 GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDIS 553
Query: 631 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN 690
D+WSLGIL+YELLTG+PPFSG D M TYN+IL+GI+ ++FP+KI + +LI++LCR N
Sbjct: 554 ADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDN 613
Query: 691 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKG- 749
P+ERLGNLKNG+ DI+KH+W GFNWEGL+ +L P+ + P D S FD +P +
Sbjct: 614 PSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDE 673
Query: 750 MPPDELSGWDKDF 762
PPD+ SGWD DF
Sbjct: 674 PPPDDNSGWDIDF 686
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 670 bits (1728), Expect = 0.0
Identities = 358/737 (48%), Positives = 483/737 (65%), Gaps = 70/737 (9%)
Query: 30 VTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQ 89
++ELE + + + +E +KEL ++LS E EE+Q +L+K Q V+ +
Sbjct: 1 MSELEEDFAKI---LMLKEERIKELEKRLS-------EKEEEIQELKRKLHKCQSVLPVP 50
Query: 90 GGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRT--YDLNKPPEFSFEKA 147
+ R G+SAEP T +DL + +F K
Sbjct: 51 S----------------------THIGPRTTRAQGISAEPQTYRSFHDLRQ----AFRK- 83
Query: 148 RVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFV 207
K K LI +A+ N F+K L+ QI+++V+CMY Y + S IIK+G+ G+ ++V
Sbjct: 84 -FTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYV 142
Query: 208 LAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMR 267
+ +G++EV + L ++ FGELAILYNCTRTA+VK + NVK WA+DR+ FQ IM
Sbjct: 143 MEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMM 202
Query: 268 RTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA 327
RT + +Y FL+SV ++LPE+ L+K+ D LE +Y+ G+YIIR+G G TFFI++
Sbjct: 203 RTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS 262
Query: 328 KGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETF 387
KG V VT+ + P ++TL KG++FGEKAL +DVR+AN+IA E V CLVIDR++F
Sbjct: 263 KGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSF 321
Query: 388 NQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSS 447
+G ++ V+N +D + AK E A F ++
Sbjct: 322 KHLIGGLDD--------VSNKAYEDAEAKAKY-------------------EAEAAFFAN 354
Query: 448 SPFQNLEIIATLGVGGFGRVELVKVKNE-NVAFAMKCIRKKHIVDTKQQEHVYSEKRILE 506
+ II TLGVGGFGRVELV++K+E + FAMK ++K+HIVDT+QQEH+ SEK+I++
Sbjct: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
Query: 507 ELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDY 566
S FIV+LYRTFKD+KY+YML+EACLGGELW+ILRDRGSF++ T++F ACV EAF Y
Sbjct: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
Query: 567 LHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKG 626
LH GIIYRDLKPENLILD GY KLVDFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKG
Sbjct: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKG 534
Query: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRL 686
HD S D+WSLGIL+YELLTG+PPFSG D M TYN+IL+GI+ ++FP+KI + +LI++L
Sbjct: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
Query: 687 CRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPP 746
CR NP+ERLGNLKNG+ DI+KH+W GFNWEGL+ +L P+ + P D S FD +P
Sbjct: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 654
Query: 747 EKG-MPPDELSGWDKDF 762
+ PPD+ SGWD DF
Sbjct: 655 DNDEPPPDDNSGWDIDF 671
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 285 bits (729), Expect = 1e-76
Identities = 139/295 (47%), Positives = 199/295 (67%), Gaps = 4/295 (1%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
Q+ + +AT+G G FGRV LVK K FA+K + ++ KQ++HV++EK +L+E+
Sbjct: 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Query: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570
PF+++L+ T+ D +++YML+E GGEL+S LR+RG F T F A + A +YLH
Sbjct: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
Query: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 630
I+YRDLKPEN++LD +G++KL DFGFAKK+ +TWT CGTPEY+APEVI +KGH +
Sbjct: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHGRA 224
Query: 631 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN 690
VD+W+LGIL++E+L+G PPF + Y IL G K+DFPR + +DLI++L +
Sbjct: 225 VDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLVVD 282
Query: 691 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYP 745
T RLGN+KNG ND+K HRW +WE + R L P+ ++ G D S F+ YP
Sbjct: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 282 bits (722), Expect = 7e-76
Identities = 144/307 (46%), Positives = 200/307 (65%), Gaps = 10/307 (3%)
Query: 448 SPFQN------LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSE 501
SP QN E I TLG G FGRV LVK K +AMK + K+ +V KQ EH +E
Sbjct: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
Query: 502 KRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
KRIL+ + PF+VKL +FKDN +YM++E GGE++S LR G F EP ++F A +
Sbjct: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEV 621
F+YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+
Sbjct: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 202
Query: 622 ILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPED 681
IL+KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+ FP + +D
Sbjct: 203 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKD 260
Query: 682 LIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF 741
L+R L + + T+R GNLKNG+NDIK H+W +W + R + +P + KGP D S F
Sbjct: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
Query: 742 DKYPPEK 748
D Y E+
Sbjct: 321 DDYEEEE 327
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 282 bits (722), Expect = 7e-76
Identities = 144/307 (46%), Positives = 200/307 (65%), Gaps = 10/307 (3%)
Query: 448 SPFQN------LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSE 501
SP QN E I TLG G FGRV LVK K +AMK + K+ +V KQ EH +E
Sbjct: 33 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92
Query: 502 KRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
KRIL+ + PF+VKL +FKDN +YM++E GGE++S LR G F EP ++F A +
Sbjct: 93 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEV 621
F+YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+
Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 210
Query: 622 ILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPED 681
IL+KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+ FP + +D
Sbjct: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKD 268
Query: 682 LIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF 741
L+R L + + T+R GNLKNG+NDIK H+W +W + R + +P + KGP D S F
Sbjct: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328
Query: 742 DKYPPEK 748
D Y E+
Sbjct: 329 DDYEEEE 335
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 278 bits (710), Expect = 2e-74
Identities = 159/377 (42%), Positives = 226/377 (59%), Gaps = 22/377 (5%)
Query: 388 NQTVGTFEELQKYLEGYVANLNRDDEKRHA---KRSMSNWKL--SKALSLEMIQLKEKVA 442
NQ GT LQK LEG+ + L K A K ++ N L S+ +L +KE +A
Sbjct: 10 NQYTGTTTALQK-LEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWDRSMKEFLA 68
Query: 443 RFSSS------SPFQN------LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIV 490
+ +P QN E TLG G FGRV LVK K +AMK + K+ +V
Sbjct: 69 KAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVV 128
Query: 491 DTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDE 550
KQ EH +EKRIL+ + PF+V+L FKDN +YM++E GGE++S LR G F E
Sbjct: 129 KLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 188
Query: 551 PTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTF 610
P ++F A + F+YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT
Sbjct: 189 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTL 246
Query: 611 CGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD 670
CGTPEY+APE+IL+KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+
Sbjct: 247 CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVR 304
Query: 671 FPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQR 730
FP + +DL+R L + + T+R GNLKNG++DIK H+W +W + R + +P
Sbjct: 305 FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 364
Query: 731 ELKGPIDHSYFDKYPPE 747
+ +G D S FD Y E
Sbjct: 365 KFRGSGDTSNFDDYEEE 381
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 271 bits (693), Expect = 2e-72
Identities = 135/302 (44%), Positives = 197/302 (65%), Gaps = 4/302 (1%)
Query: 446 SSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL 505
+++ ++ E TLG G FGRV LVK K +AMK + K+ +V KQ EH +EKRIL
Sbjct: 37 NNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
Query: 506 EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565
+ + PF+V+L FKDN +YM++E GGE++S LR G F EP ++F A + F+
Sbjct: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Query: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNK 625
YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+IL+K
Sbjct: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSK 214
Query: 626 GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRR 685
G++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+ FP + +DL+R
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 272
Query: 686 LCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYP 745
L + + T+R GNLKNG++DIK H+W +W + R + +P + +G D S FD Y
Sbjct: 273 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 332
Query: 746 PE 747
E
Sbjct: 333 EE 334
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 270 bits (689), Expect = 5e-72
Identities = 135/304 (44%), Positives = 200/304 (65%), Gaps = 7/304 (2%)
Query: 445 SSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI 504
+SS F+ L TLG+G FGRV LV+ + +AMK + K+ +V KQ EH+ +EKRI
Sbjct: 39 ASSDQFERLR---TLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRI 95
Query: 505 LEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAF 564
L+ + PF+VKL +FKDN Y+Y+++E GGE++S L+ G F EP + F A V A
Sbjct: 96 LQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAV 155
Query: 565 DYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN 624
YLH L +I+RDLKPENL++D +GYL++ DFGFAK++ +TWT CGTPEY+APE+IL+
Sbjct: 156 QYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS 213
Query: 625 KGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIR 684
KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G ++ FP K++ + L+R
Sbjct: 214 KGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLR 271
Query: 685 RLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKY 744
L + + T+R GNL+NG+ DIK H+W +W + + + +P + GP D S FD Y
Sbjct: 272 SLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDY 331
Query: 745 PPEK 748
E+
Sbjct: 332 EEEE 335
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 222 bits (565), Expect = 1e-57
Identities = 123/294 (41%), Positives = 183/294 (62%), Gaps = 7/294 (2%)
Query: 454 EIIATLGVGGFGRV-ELVKVKNENVA--FAMKCIRKKHIV-DTKQQEHVYSEKRILEELC 509
E++ LG GG+G+V ++ KV N FAMK ++K IV + K H +E+ ILEE+
Sbjct: 92 ELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVK 151
Query: 510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR 569
PFIV L F+ +Y++LE GGEL+ L G F E T+ F +A ++ A +LH+
Sbjct: 152 HPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQ 211
Query: 570 LGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHD 628
GIIYRDLKPEN++L+ +G++KL DFG K+ I G T TFCGT EY+APE+++ GH+
Sbjct: 212 KGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHN 271
Query: 629 FSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCR 688
+VD+WSLG L+Y++LTG PPF+G ++ T + ILK K++ P +T+ DL+++L +
Sbjct: 272 RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC--KLNLPPYLTQEARDLLKKLLK 329
Query: 689 QNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD 742
+N RLG +++ H + NWE L AR + P + L+ D S FD
Sbjct: 330 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD 383
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 222 bits (565), Expect = 1e-57
Identities = 119/294 (40%), Positives = 186/294 (63%), Gaps = 7/294 (2%)
Query: 454 EIIATLGVGGFGRV-ELVKVKNENVA--FAMKCIRKKHIV-DTKQQEHVYSEKRILEELC 509
E++ LG GG+G+V ++ KV+ N+ +AMK +RK IV + K H +E+ ILE +
Sbjct: 68 ELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK 127
Query: 510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR 569
PFIV+L F+ +Y++LE GGEL++ L G F E T+ F +A +T A +LH
Sbjct: 128 HPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHS 187
Query: 570 LGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHD 628
GIIYRDLKPEN++L ++G++KL DFG K+ I G T TFCGT EY+APE+++ GH+
Sbjct: 188 QGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247
Query: 629 FSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCR 688
+VD+WSLG L+Y++LTG+PPF+ ++ T + I++G K+ P +T DL+++ +
Sbjct: 248 RAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG--KLALPPYLTPDARDLVKKFLK 305
Query: 689 QNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD 742
+NP++R+G D+++H + NW+ L A + P + L+ D S FD
Sbjct: 306 RNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFD 359
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 220 bits (561), Expect = 3e-57
Identities = 127/336 (37%), Positives = 196/336 (58%), Gaps = 13/336 (3%)
Query: 427 SKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA---FAMKC 483
++ +S++ I + V + E++ LG G FG+V LVK + + A +AMK
Sbjct: 42 TEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKV 101
Query: 484 IRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILR 543
+ KK + + + E+ IL E+ PFIVKL+ F+ +Y++L+ GG+L++ L
Sbjct: 102 L-KKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS 160
Query: 544 DRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IG 602
F E KF +A + A D+LH LGIIYRDLKPEN++LD EG++KL DFG +K+ I
Sbjct: 161 KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID 220
Query: 603 SGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLI 662
+K ++FCGT EY+APEV+ +GH S D+WS G+L++E+LTG PF G D+ T +I
Sbjct: 221 HEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMI 280
Query: 663 LKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKAR 722
LK K+ P+ ++ + L+R L ++NP RLG +G+ +IK+H + + +W L R
Sbjct: 281 LKA--KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRR 338
Query: 723 SLPSPLQRELKGPIDHSYFD-----KYPPEK-GMPP 752
+ P + P D YFD K P + G+PP
Sbjct: 339 EIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPP 374
Score = 119 bits (298), Expect = 1e-26
Identities = 82/276 (29%), Positives = 139/276 (50%), Gaps = 23/276 (8%)
Query: 454 EIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFI 513
E+ +GVG + + K N+ FA+K I+D +++ + +L P I
Sbjct: 423 EVKEDIGVGSYSVCKRCIHKATNMEFAVK------IIDKSKRDPTEEIEILLRYGQHPNI 476
Query: 514 VKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGII 573
+ L + D KYVY++ E GGEL + + F E + + +T+ +YLH G++
Sbjct: 477 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 536
Query: 574 YRDLKPENLI-LDAEG---YLKLVDFGFAKKI-GSGQKTWTFCGTPEYVAPEVILNKGHD 628
+RDLKP N++ +D G +++ DFGFAK++ T C T +VAPEV+ +G+D
Sbjct: 537 HRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 596
Query: 629 FSVDFWSLGILVYELLTGNPPF-SGVDQMMTYNLILKGIEKMD----FPRKITRRPEDLI 683
+ D WSLG+L+Y +LTG PF +G D L G K + ++ +DL+
Sbjct: 597 AACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLV 656
Query: 684 RRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGL 719
++ +P +RL + +H W+ +W+ L
Sbjct: 657 SKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQL 685
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 218 bits (554), Expect = 2e-56
Identities = 105/220 (47%), Positives = 151/220 (68%), Gaps = 2/220 (0%)
Query: 446 SSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL 505
+++ ++ E TLG G FGRV LVK K +AMK + K+ +V KQ EH +EKRIL
Sbjct: 37 NNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
Query: 506 EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565
+ + PF+V+L FKDN +YM++E GGE++S LR G F EP ++F A + F+
Sbjct: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Query: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNK 625
YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+IL+K
Sbjct: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSK 214
Query: 626 GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKG 665
G++ +VD+W+LG+L+YE+ G PPF + Y I+ G
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 217 bits (553), Expect = 3e-56
Identities = 123/331 (37%), Positives = 193/331 (58%), Gaps = 13/331 (3%)
Query: 432 LEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV---KNENVAFAMKCIRKKH 488
L+ I + V S + + E++ LG G FG+V LV+ + +AMK + KK
Sbjct: 50 LKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKA 108
Query: 489 IVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSF 548
+ + + E+ IL ++ PF+VKL+ F+ +Y++L+ GG+L++ L F
Sbjct: 109 TLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 168
Query: 549 DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKT 607
E KF +A + D+LH LGIIYRDLKPEN++LD EG++KL DFG +K+ I +K
Sbjct: 169 TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA 228
Query: 608 WTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIE 667
++FCGT EY+APEV+ +GH S D+WS G+L++E+LTG+ PF G D+ T LILK
Sbjct: 229 YSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA-- 286
Query: 668 KMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSP 727
K+ P+ ++ + L+R L ++NP RLG+ +G +IK+H + + +W L R + P
Sbjct: 287 KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPP 346
Query: 728 LQRELKGPIDHSYFD-----KYPPEK-GMPP 752
+ + P D YFD + P + G+PP
Sbjct: 347 FKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP 377
Score = 114 bits (286), Expect = 3e-25
Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 23/265 (8%)
Query: 458 TLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLY 517
T+GVG + + K N+ +A+K ++D +++ + +L P I+ L
Sbjct: 432 TIGVGSYSECKRCVHKATNMEYAVK------VIDKSKRDPSEEIEILLRYGQHPNIITLK 485
Query: 518 RTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDL 577
+ D K+VY++ E GGEL + + F E + F + + + +YLH G+++RDL
Sbjct: 486 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 545
Query: 578 KPENLI-LDAEG---YLKLVDFGFAKKI-GSGQKTWTFCGTPEYVAPEVILNKGHDFSVD 632
KP N++ +D G L++ DFGFAK++ T C T +VAPEV+ +G+D D
Sbjct: 546 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 605
Query: 633 FWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP------RKITRRPEDLIRRL 686
WSLGIL+Y +L G PF+ T IL I F ++ +DL+ ++
Sbjct: 606 IWSLGILLYTMLAGYTPFAN-GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKM 664
Query: 687 CRQNPTERLGNLKNGINDIKKHRWL 711
+P +RL + +H W+
Sbjct: 665 LHVDPHQRL-----TAKQVLQHPWV 684
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 217 bits (553), Expect = 3e-56
Identities = 123/331 (37%), Positives = 193/331 (58%), Gaps = 13/331 (3%)
Query: 432 LEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKV---KNENVAFAMKCIRKKH 488
L+ I + V S + + E++ LG G FG+V LV+ + +AMK + KK
Sbjct: 41 LKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKA 99
Query: 489 IVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSF 548
+ + + E+ IL ++ PF+VKL+ F+ +Y++L+ GG+L++ L F
Sbjct: 100 TLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF 159
Query: 549 DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKT 607
E KF +A + D+LH LGIIYRDLKPEN++LD EG++KL DFG +K+ I +K
Sbjct: 160 TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA 219
Query: 608 WTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIE 667
++FCGT EY+APEV+ +GH S D+WS G+L++E+LTG+ PF G D+ T LILK
Sbjct: 220 YSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA-- 277
Query: 668 KMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSP 727
K+ P+ ++ + L+R L ++NP RLG+ +G +IK+H + + +W L R + P
Sbjct: 278 KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPP 337
Query: 728 LQRELKGPIDHSYFD-----KYPPEK-GMPP 752
+ + P D YFD + P + G+PP
Sbjct: 338 FKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP 368
Score = 114 bits (286), Expect = 3e-25
Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 23/265 (8%)
Query: 458 TLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLY 517
T+GVG + + K N+ +A+K ++D +++ + +L P I+ L
Sbjct: 423 TIGVGSYSECKRCVHKATNMEYAVK------VIDKSKRDPSEEIEILLRYGQHPNIITLK 476
Query: 518 RTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDL 577
+ D K+VY++ E GGEL + + F E + F + + + +YLH G+++RDL
Sbjct: 477 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 536
Query: 578 KPENLI-LDAEG---YLKLVDFGFAKKI-GSGQKTWTFCGTPEYVAPEVILNKGHDFSVD 632
KP N++ +D G L++ DFGFAK++ T C T +VAPEV+ +G+D D
Sbjct: 537 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 596
Query: 633 FWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP------RKITRRPEDLIRRL 686
WSLGIL+Y +L G PF+ T IL I F ++ +DL+ ++
Sbjct: 597 IWSLGILLYTMLAGYTPFAN-GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKM 655
Query: 687 CRQNPTERLGNLKNGINDIKKHRWL 711
+P +RL + +H W+
Sbjct: 656 LHVDPHQRL-----TAKQVLQHPWV 675
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 213 bits (541), Expect = 7e-55
Identities = 130/352 (36%), Positives = 207/352 (58%), Gaps = 19/352 (5%)
Query: 414 KRHAKRSMSNWKLSKALSLEMIQLKEKVAR-FSSSSPFQNLEIIATLGVGGFGRVELV-K 471
++ +S S +L + ++ I + V F + P Q E++ LG G +G+V LV K
Sbjct: 20 RKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQ-FELLKVLGQGSYGKVFLVRK 78
Query: 472 VKNENVA--FAMKCIRKKHIVDTKQQEHVYS--EKRILEELCSPFIVKLYRTFKDNKYVY 527
VK + +AMK ++K + K ++ V S E+ IL E+ PFIVKL+ F+ +Y
Sbjct: 79 VKGSDAGQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLY 135
Query: 528 MLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAE 587
++L+ GG+L++ L F E KF +A + A D+LH LGIIYRDLKPEN++LD E
Sbjct: 136 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE 195
Query: 588 GYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTG 646
G++K+ DFG +K+ I ++ ++FCGT EY+APEV+ +GH S D+WS G+L++E+LTG
Sbjct: 196 GHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255
Query: 647 NPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIK 706
+ PF G D+ T LILK K+ P+ ++ + L+R L ++NP RLG +G+ +IK
Sbjct: 256 SLPFQGKDRKETMALILKA--KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIK 313
Query: 707 KHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD-----KYPPEK-GMPP 752
+H + +W L + + P + + P D +FD + P + G+PP
Sbjct: 314 RHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP 365
Score = 120 bits (302), Expect = 4e-27
Identities = 88/298 (29%), Positives = 146/298 (48%), Gaps = 23/298 (7%)
Query: 454 EIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFI 513
EI +GVG + + K + +A+K I+D +++ + +L P I
Sbjct: 416 EIKEDIGVGSYSVCKRCVHKATDTEYAVK------IIDKSKRDPSEEIEILLRYGQHPNI 469
Query: 514 VKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGII 573
+ L + D K+VY+++E GGEL + + F E + + +T+ DYLH G++
Sbjct: 470 ITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVV 529
Query: 574 YRDLKPENLILDAEG----YLKLVDFGFAKKIGSGQ-KTWTFCGTPEYVAPEVILNKGHD 628
+RDLKP N++ E +++ DFGFAK++ +G T C T +VAPEV+ +G+D
Sbjct: 530 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 589
Query: 629 FSVDFWSLGILVYELLTGNPPF-SGVDQMMTYNLILKGIEKMDFP----RKITRRPEDLI 683
+ D WSLGIL+Y +L G PF +G D L G K I+ +D++
Sbjct: 590 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 649
Query: 684 RRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF 741
++ +P +RL ++ + KH W+ N E L L +KG + +YF
Sbjct: 650 SKMLHVDPHQRLTAMQ-----VLKHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYF 700
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 212 bits (540), Expect = 9e-55
Identities = 125/321 (38%), Positives = 194/321 (60%), Gaps = 18/321 (5%)
Query: 444 FSSSSPFQNLEIIATLGVGGFGRVELV-KVKNENVA--FAMKCIRKKHIVDTKQQEHVYS 500
F + P Q E++ LG G +G+V LV KVK + +AMK ++K + K ++ V S
Sbjct: 59 FEKADPSQ-FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL---KVRDRVRS 114
Query: 501 --EKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVA 558
E+ IL E+ PFIVKL+ F+ +Y++L+ GG+L++ L F E KF +A
Sbjct: 115 KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 174
Query: 559 CVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYV 617
+ A D+LH LGIIYRDLKPEN++LD EG++K+ DFG +K+ I ++ ++FCGT EY+
Sbjct: 175 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYM 234
Query: 618 APEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITR 677
APEV+ +GH S D+WS G+L++E+LTG+ PF G D+ T LILK K+ P+ ++
Sbjct: 235 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKA--KLGMPQFLSG 292
Query: 678 RPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPID 737
+ L+R L ++NP RLG +G+ +IK+H + +W L + + P + + P D
Sbjct: 293 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 352
Query: 738 HSYFD-----KYPPEK-GMPP 752
+FD + P + G+PP
Sbjct: 353 TFHFDPEFTARTPTDSPGVPP 373
Score = 120 bits (302), Expect = 4e-27
Identities = 88/298 (29%), Positives = 146/298 (48%), Gaps = 23/298 (7%)
Query: 454 EIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFI 513
EI +GVG + + K + +A+K I+D +++ + +L P I
Sbjct: 424 EIKEDIGVGSYSVCKRCVHKATDTEYAVK------IIDKSKRDPSEEIEILLRYGQHPNI 477
Query: 514 VKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGII 573
+ L + D K+VY+++E GGEL + + F E + + +T+ DYLH G++
Sbjct: 478 ITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVV 537
Query: 574 YRDLKPENLILDAEG----YLKLVDFGFAKKIGSGQ-KTWTFCGTPEYVAPEVILNKGHD 628
+RDLKP N++ E +++ DFGFAK++ +G T C T +VAPEV+ +G+D
Sbjct: 538 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 597
Query: 629 FSVDFWSLGILVYELLTGNPPF-SGVDQMMTYNLILKGIEKMDFP----RKITRRPEDLI 683
+ D WSLGIL+Y +L G PF +G D L G K I+ +D++
Sbjct: 598 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 657
Query: 684 RRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF 741
++ +P +RL ++ + KH W+ N E L L +KG + +YF
Sbjct: 658 SKMLHVDPHQRLTAMQ-----VLKHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYF 708
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 212 bits (539), Expect = 1e-54
Identities = 115/297 (38%), Positives = 175/297 (58%), Gaps = 7/297 (2%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
++ + +A LG G FG+V L + + FA+K ++K IV + E + EKRIL + S
Sbjct: 619 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 678
Query: 511 ---PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567
PF+V L+ F+ ++V ++E GG+L + F EP + F ACV +L
Sbjct: 679 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 737
Query: 568 HRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKG 626
H I+YRDLK +NL+LD EGY+K+ DFG K+ +G G +T TFCGTPE++APEV+ +
Sbjct: 738 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 797
Query: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRL 686
+ +VD+W LG+L+YE+L G PF G D+ ++ I+ +++ +PR ++ ++RRL
Sbjct: 798 YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRFLSAEAIGIMRRL 855
Query: 687 CRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDK 743
R+NP RLG+ + D+KK + WE L AR LP P L G D S FD+
Sbjct: 856 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 212 bits (539), Expect = 1e-54
Identities = 115/297 (38%), Positives = 175/297 (58%), Gaps = 7/297 (2%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
++ + +A LG G FG+V L + + FA+K ++K IV + E + EKRIL + S
Sbjct: 613 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 672
Query: 511 ---PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567
PF+V L+ F+ ++V ++E GG+L + F EP + F ACV +L
Sbjct: 673 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 731
Query: 568 HRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKG 626
H I+YRDLK +NL+LD EGY+K+ DFG K+ +G G +T TFCGTPE++APEV+ +
Sbjct: 732 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 791
Query: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRL 686
+ +VD+W LG+L+YE+L G PF G D+ ++ I+ +++ +PR ++ ++RRL
Sbjct: 792 YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRFLSAEAIGIMRRL 849
Query: 687 CRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDK 743
R+NP RLG+ + D+KK + WE L AR LP P L G D S FD+
Sbjct: 850 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 906
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 211 bits (538), Expect = 2e-54
Identities = 113/296 (38%), Positives = 172/296 (58%), Gaps = 7/296 (2%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 510
Q+ A LG G FG+V L + KN N FA+K ++K IV + + + EKRI E + S
Sbjct: 655 QDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNS 714
Query: 511 ---PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567
PF+V L+ F+ ++V ++E GG+L + F EP + F ACV YL
Sbjct: 715 VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQYL 773
Query: 568 HRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKG 626
H I+YRDLK +NL+LD EG++K+ DFG K+ +G G +T TFCGTPE++APEV+
Sbjct: 774 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 833
Query: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRL 686
+ +VD+W LG+L+YE+L G PF G D+ ++ I+ +++ +PR ++ ++RRL
Sbjct: 834 YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRFLSTEAISIMRRL 891
Query: 687 CRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD 742
R+NP RLG + D+KKH + +W L + + P ++G D S FD
Sbjct: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 209 bits (533), Expect = 6e-54
Identities = 116/303 (38%), Positives = 182/303 (60%), Gaps = 10/303 (3%)
Query: 444 FSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVA---FAMKCIRKKHIVDTKQQEHVYS 500
+ + P Q E++ LG G FG+V LV+ K A +AMK ++K + + +
Sbjct: 65 YEKADPAQ-FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL-KVRDRVRTKM 122
Query: 501 EKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACV 560
E+ IL E+ PFIVKL+ F+ +Y++L+ GG++++ L F E KF +A +
Sbjct: 123 ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 182
Query: 561 TEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAP 619
A D+LH+LGI+YRDLKPEN++LD G++KL DFG +K+ + +K ++FCGT EY+AP
Sbjct: 183 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAP 242
Query: 620 EVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRP 679
EV+ +GH S D+WS G+L++E+LTG PF G D+ T N+ILK K+ P+ ++
Sbjct: 243 EVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKA--KLGMPQFLSAEA 300
Query: 680 EDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHS 739
+ L+R L ++NP RLG+ G+ +IK+H + +W+ L R + P + P D
Sbjct: 301 QSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTF 358
Query: 740 YFD 742
FD
Sbjct: 359 CFD 361
Score = 116 bits (291), Expect = 7e-26
Identities = 81/296 (27%), Positives = 142/296 (47%), Gaps = 26/296 (8%)
Query: 426 LSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIR 485
++ A L ++Q+ A+F + E+ +GVG + + N+ FA+K
Sbjct: 404 ITSANVLPIVQINGNAAQFG-----EVYELKEDIGVGSYSVCKRCIHATTNMEFAVK--- 455
Query: 486 KKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDR 545
I+D +++ + ++ P I+ L F D +YVY++ + GGEL + +
Sbjct: 456 ---IIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQ 512
Query: 546 GSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEG----YLKLVDFGFAKKI 601
F E + + +++ DYLH G+++RDLKP N++ E +++ DFGFAK++
Sbjct: 513 KCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL 572
Query: 602 -GSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 660
G T C T +VAPEV++ +G+D + D WSLG+L Y +L G PF+
Sbjct: 573 RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 661 LILK-GIEKMDFP----RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL 711
++L+ G K I+ +DL+ + +P +R I KH W+
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY-----TAEQILKHSWI 683
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 202 bits (514), Expect = 9e-52
Identities = 114/311 (36%), Positives = 182/311 (58%), Gaps = 8/311 (2%)
Query: 446 SSSPF---QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEK 502
SS+P + + +G G FG+V L + K E V +A+K ++KK I+ K+++H+ SE+
Sbjct: 88 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 147
Query: 503 RIL-EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
+L + + PF+V L+ +F+ +Y +L+ GGEL+ L+ F EP ++F A +
Sbjct: 148 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 207
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPE 620
A YLH L I+YRDLKPEN++LD++G++ L DFG K+ I T TFCGTPEY+APE
Sbjct: 208 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 267
Query: 621 VILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPE 680
V+ + +D +VD+W LG ++YE+L G PPF + Y+ IL + + IT
Sbjct: 268 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSAR 325
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
L+ L +++ T+RLG K+ +IK H + + NW+ L + + P + GP D +
Sbjct: 326 HLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 384
Query: 741 FDKYPPEKGMP 751
FD E+ +P
Sbjct: 385 FDPEFTEEPVP 395
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 202 bits (514), Expect = 9e-52
Identities = 114/311 (36%), Positives = 182/311 (58%), Gaps = 8/311 (2%)
Query: 446 SSSPF---QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEK 502
SS+P + + +G G FG+V L + K E V +A+K ++KK I+ K+++H+ SE+
Sbjct: 102 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 161
Query: 503 RIL-EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
+L + + PF+V L+ +F+ +Y +L+ GGEL+ L+ F EP ++F A +
Sbjct: 162 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 221
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPE 620
A YLH L I+YRDLKPEN++LD++G++ L DFG K+ I T TFCGTPEY+APE
Sbjct: 222 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 281
Query: 621 VILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPE 680
V+ + +D +VD+W LG ++YE+L G PPF + Y+ IL + + IT
Sbjct: 282 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSAR 339
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
L+ L +++ T+RLG K+ +IK H + + NW+ L + + P + GP D +
Sbjct: 340 HLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 398
Query: 741 FDKYPPEKGMP 751
FD E+ +P
Sbjct: 399 FDPEFTEEPVP 409
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 202 bits (514), Expect = 9e-52
Identities = 114/311 (36%), Positives = 182/311 (58%), Gaps = 8/311 (2%)
Query: 446 SSSPF---QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEK 502
SS+P + + +G G FG+V L + K E V +A+K ++KK I+ K+++H+ SE+
Sbjct: 116 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 175
Query: 503 RIL-EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
+L + + PF+V L+ +F+ +Y +L+ GGEL+ L+ F EP ++F A +
Sbjct: 176 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 235
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPE 620
A YLH L I+YRDLKPEN++LD++G++ L DFG K+ I T TFCGTPEY+APE
Sbjct: 236 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 295
Query: 621 VILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPE 680
V+ + +D +VD+W LG ++YE+L G PPF + Y+ IL + + IT
Sbjct: 296 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSAR 353
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
L+ L +++ T+RLG K+ +IK H + + NW+ L + + P + GP D +
Sbjct: 354 HLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 412
Query: 741 FDKYPPEKGMP 751
FD E+ +P
Sbjct: 413 FDPEFTEEPVP 423
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 202 bits (514), Expect = 9e-52
Identities = 114/311 (36%), Positives = 182/311 (58%), Gaps = 8/311 (2%)
Query: 446 SSSPF---QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEK 502
SS+P + + +G G FG+V L + K E V +A+K ++KK I+ K+++H+ SE+
Sbjct: 183 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 242
Query: 503 RIL-EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
+L + + PF+V L+ +F+ +Y +L+ GGEL+ L+ F EP ++F A +
Sbjct: 243 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 302
Query: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPE 620
A YLH L I+YRDLKPEN++LD++G++ L DFG K+ I T TFCGTPEY+APE
Sbjct: 303 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 362
Query: 621 VILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPE 680
V+ + +D +VD+W LG ++YE+L G PPF + Y+ IL + + IT
Sbjct: 363 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSAR 420
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
L+ L +++ T+RLG K+ +IK H + + NW+ L + + P + GP D +
Sbjct: 421 HLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 479
Query: 741 FDKYPPEKGMP 751
FD E+ +P
Sbjct: 480 FDPEFTEEPVP 490
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 202 bits (514), Expect = 9e-52
Identities = 118/322 (36%), Positives = 193/322 (59%), Gaps = 18/322 (5%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVA---FAMKCIRKKHIVD-TKQQEHVYSEKRILE 506
+N E++ LG G +G+V LV+ + A +AMK +RK +V K QEH +E+ +LE
Sbjct: 31 ENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLE 90
Query: 507 ELC-SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565
+ +PF+V L+ F+ + ++++L+ GGE+++ L R F E + + A +
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQK--TWTFCGTPEYVAPEVIL 623
+LH+LGIIYRDLK EN++LD+EG++ L DFG +K+ + +K T++FCGT EY+APE+I
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
Query: 624 NK-GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD--FPRKITRRPE 680
+K GH +VD+WSLGIL++ELLTG PF+ + T + + I K FP +I +
Sbjct: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
DL++RL ++P +RLG G +++ H + G +W L AR +P+P + +++ +D
Sbjct: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
Query: 741 FDK--------YPPEKGMPPDE 754
F + Y P PP +
Sbjct: 331 FAEEFTRLEPVYSPPGSPPPGD 352
Score = 108 bits (271), Expect = 1e-23
Identities = 86/298 (28%), Positives = 141/298 (47%), Gaps = 39/298 (13%)
Query: 459 LGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS--PFIVKL 516
LG G F + + FA+K + ++ +T+++ LC P +V L
Sbjct: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL-------RLCQSHPNVVNL 463
Query: 517 YRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR-LGIIYR 575
+ D + Y++LE GGEL +R + F E + + + A ++H G+++R
Sbjct: 464 HEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHR 523
Query: 576 DLKPENLIL--DAEGY-LKLVDFGFAK--KIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 630
DLKPEN++ D G +K++DFGFA+ G T C T +Y APE++ +G+D S
Sbjct: 524 DLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDES 583
Query: 631 VDFWSLGILVYELLTGNPPFSGVD----QMMTYNLILK---GIEKMDFP--RKITRRPED 681
D WSLG+++Y +L+G PF G Q ++ K G +D + ++ ++
Sbjct: 584 CDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKE 643
Query: 682 LIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNW-EGLKARSLP---SPLQRELKGP 735
L+R L +P +RL K L G +W + ARS P +P E GP
Sbjct: 644 LVRGLLTVDPAKRL-----------KLEGLRGSSWLQDGSARSSPPLRTPDVLESSGP 690
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 202 bits (514), Expect = 9e-52
Identities = 118/322 (36%), Positives = 193/322 (59%), Gaps = 18/322 (5%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVA---FAMKCIRKKHIVD-TKQQEHVYSEKRILE 506
+N E++ LG G +G+V LV+ + A +AMK +RK +V K QEH +E+ +LE
Sbjct: 31 ENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLE 90
Query: 507 EL-CSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565
+ +PF+V L+ F+ + ++++L+ GGE+++ L R F E + + A +
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQK--TWTFCGTPEYVAPEVIL 623
+LH+LGIIYRDLK EN++LD+EG++ L DFG +K+ + +K T++FCGT EY+APE+I
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
Query: 624 NK-GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD--FPRKITRRPE 680
+K GH +VD+WSLGIL++ELLTG PF+ + T + + I K FP +I +
Sbjct: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
Query: 681 DLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY 740
DL++RL ++P +RLG G +++ H + G +W L AR +P+P + +++ +D
Sbjct: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
Query: 741 FDK--------YPPEKGMPPDE 754
F + Y P PP +
Sbjct: 331 FAEEFTRLEPVYSPPGSPPPGD 352
Score = 109 bits (272), Expect = 1e-23
Identities = 91/318 (28%), Positives = 147/318 (46%), Gaps = 42/318 (13%)
Query: 442 ARFSSSSPFQNLEIIA---TLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHV 498
A S FQ E+ LG G F + + FA+K + ++ +T+++
Sbjct: 397 AMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAA 456
Query: 499 YSEKRILEELCS--PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFC 556
LC P +V L+ D + Y++LE GGEL +R + F E +
Sbjct: 457 L-------RLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQI 509
Query: 557 VACVTEAFDYLHR-LGIIYRDLKPENLIL--DAEGY-LKLVDFGFAK--KIGSGQKTWTF 610
+ + A ++H G+++RDLKPEN++ D G +K++DFGFA+ G T
Sbjct: 510 LRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTP 569
Query: 611 CGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVD----QMMTYNLILK-- 664
C T +Y APE++ +G+D S D WSLG+++Y +L+G PF G Q ++ K
Sbjct: 570 CFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIR 629
Query: 665 -GIEKMDFP--RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNW-EGLK 720
G +D + ++ ++L+R L +P +RL K L G +W +
Sbjct: 630 EGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL-----------KLEGLRGSSWLQDGS 678
Query: 721 ARSLP---SPLQRELKGP 735
ARS P +P E GP
Sbjct: 679 ARSSPPLRTPDVLESSGP 696
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 201 bits (510), Expect = 3e-51
Identities = 115/308 (37%), Positives = 181/308 (58%), Gaps = 13/308 (4%)
Query: 451 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEEL-C 509
Q+ +A LG G FG+V LV+ K +A+K ++K+ ++ + E +Y EKRILE + C
Sbjct: 557 QDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGC 616
Query: 510 S--PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567
+ PF++ L F+ + + + E GG+L + + F EP ++F VACV +L
Sbjct: 617 TGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFL 675
Query: 568 HRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKG 626
H IIYRDLK +NL+LDA+G+LK+ DFG K+ IG G +T TFCGTPE++APEV+ +
Sbjct: 676 HEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEA 735
Query: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD--FPRKITRRPEDLIR 684
+ +VD+W LG+L+YE+L G PF G + ++ I+ MD +P ++ + + I+
Sbjct: 736 YTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIV----NMDAPYPGFLSVQGLEFIQ 791
Query: 685 RLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKY 744
+L ++ P +RLG + +IK + NW+ L AR++ P L GP D YF+
Sbjct: 792 KLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFE-- 849
Query: 745 PPEKGMPP 752
G+PP
Sbjct: 850 GEFTGLPP 857
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 200 bits (509), Expect = 4e-51
Identities = 110/293 (37%), Positives = 172/293 (58%), Gaps = 5/293 (1%)
Query: 452 NLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL-EELCS 510
+ + + +G G +G+V L K K++ +A+K ++KK I+ K+Q H+ +E+ +L + +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570
PF+V L +F+ + +Y +L+ GGEL+ L+ F EP ++F A V A YLH L
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHDF 629
IIYRDLKPEN++LD +G++ L DFG K+ + T TFCGTPEY+APEV+ + +D
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 630 SVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689
+VD+W LG ++YE+L G PPF D Y IL + + P T DL++ L +
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVAACDLLQSLLHK 271
Query: 690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD 742
+ +RLG+ K +IK H + + NW+ L + L P + GP D +FD
Sbjct: 272 DQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 323
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 200 bits (509), Expect = 4e-51
Identities = 110/293 (37%), Positives = 172/293 (58%), Gaps = 5/293 (1%)
Query: 452 NLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL-EELCS 510
+ + + +G G +G+V L K K++ +A+K ++KK I+ K+Q H+ +E+ +L + +
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 511 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 570
PF+V L +F+ + +Y +L+ GGEL+ L+ F EP ++F A V A YLH L
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
Query: 571 GIIYRDLKPENLILDAEGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHDF 629
IIYRDLKPEN++LD +G++ L DFG K+ + T TFCGTPEY+APEV+ + +D
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
Query: 630 SVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689
+VD+W LG ++YE+L G PPF D Y IL + + P T DL++ L +
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVAACDLLQSLLHK 331
Query: 690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFD 742
+ +RLG+ K +IK H + + NW+ L + L P + GP D +FD
Sbjct: 332 DQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,721,283
Number of Sequences: 37866
Number of extensions: 1368751
Number of successful extensions: 7821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 752
Number of HSP's successfully gapped in prelim test: 230
Number of HSP's that attempted gapping in prelim test: 4969
Number of HSP's gapped (non-prelim): 1855
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.