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Search of human proteins with 5453940
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453940 peroxisome proliferative activated receptor, delta is... 892 0.0
gi|29171750 peroxisome proliferative activated receptor, delta i... 730 0.0
gi|50348666 peroxisome proliferative activated receptor, alpha [... 560 e-160
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 560 e-160
gi|116284373 peroxisome proliferative activated receptor gamma i... 516 e-146
gi|20336229 peroxisome proliferative activated receptor gamma is... 516 e-146
gi|116284368 peroxisome proliferative activated receptor gamma i... 516 e-146
gi|116284370 peroxisome proliferative activated receptor gamma i... 516 e-146
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 172 4e-43
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 172 4e-43
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 172 4e-43
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 172 7e-43
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 168 8e-42
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 168 8e-42
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 152 6e-37
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 152 6e-37
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 152 6e-37
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 150 2e-36
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 144 2e-34
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 144 2e-34
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 142 6e-34
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 135 1e-31
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 134 1e-31
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 134 1e-31
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 134 1e-31
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 134 2e-31
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 133 3e-31
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 125 1e-28
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 124 1e-28
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 124 1e-28
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 892 bits (2306), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
Sbjct: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
Query: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
Sbjct: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
Query: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
Sbjct: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
Query: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
Sbjct: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
Query: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
Sbjct: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
Query: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD 360
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
Sbjct: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD 360
Query: 361 RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI 420
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
Sbjct: 361 RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI 420
Query: 421 KKTETETSLHPLLQEIYKDMY 441
KKTETETSLHPLLQEIYKDMY
Sbjct: 421 KKTETETSLHPLLQEIYKDMY 441
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 730 bits (1884), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
Sbjct: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
Query: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
Sbjct: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
Query: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
Sbjct: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
Query: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
Sbjct: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
Query: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
Sbjct: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
Query: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG
Sbjct: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 560 bits (1444), Expect = e-160
Identities = 275/398 (69%), Positives = 332/398 (83%), Gaps = 2/398 (0%)
Query: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
Query: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
Query: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
Query: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 252 KTLVAKLVANGIQN-KEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
Query: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
Query: 344 DDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKM 403
DDSD++LF+AAII CGDRPGL+NV +E +Q+ I+ L HLQ+NHPD +LFPKLLQKM
Sbjct: 371 DDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKM 430
Query: 404 ADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
ADLRQLVTEHAQ++Q IKKTE++ +LHPLLQEIY+DMY
Sbjct: 431 ADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 560 bits (1444), Expect = e-160
Identities = 275/398 (69%), Positives = 332/398 (83%), Gaps = 2/398 (0%)
Query: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
Query: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
Query: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
Query: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 252 KTLVAKLVANGIQN-KEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
Query: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
Query: 344 DDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKM 403
DDSD++LF+AAII CGDRPGL+NV +E +Q+ I+ L HLQ+NHPD +LFPKLLQKM
Sbjct: 371 DDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKM 430
Query: 404 ADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
ADLRQLVTEHAQ++Q IKKTE++ +LHPLLQEIY+DMY
Sbjct: 431 ADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 516 bits (1329), Expect = e-146
Identities = 249/396 (62%), Positives = 319/396 (80%), Gaps = 4/396 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMAD 405
SDLA+FIA IIL GDRPGL+NV +E IQD +L+ALE L+ NHP++ LF KLLQKM D
Sbjct: 382 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 441
Query: 406 LRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
LRQ+VTEH Q++Q IKKTET+ SLHPLLQEIYKD+Y
Sbjct: 442 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 516 bits (1329), Expect = e-146
Identities = 249/396 (62%), Positives = 319/396 (80%), Gaps = 4/396 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 111 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 170
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 171 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 229
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 230 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 289
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 290 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 349
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 350 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 409
Query: 346 SDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMAD 405
SDLA+FIA IIL GDRPGL+NV +E IQD +L+ALE L+ NHP++ LF KLLQKM D
Sbjct: 410 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 469
Query: 406 LRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
LRQ+VTEH Q++Q IKKTET+ SLHPLLQEIYKD+Y
Sbjct: 470 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 516 bits (1329), Expect = e-146
Identities = 249/396 (62%), Positives = 319/396 (80%), Gaps = 4/396 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMAD 405
SDLA+FIA IIL GDRPGL+NV +E IQD +L+ALE L+ NHP++ LF KLLQKM D
Sbjct: 382 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 441
Query: 406 LRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
LRQ+VTEH Q++Q IKKTET+ SLHPLLQEIYKD+Y
Sbjct: 442 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 516 bits (1329), Expect = e-146
Identities = 249/396 (62%), Positives = 319/396 (80%), Gaps = 4/396 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMAD 405
SDLA+FIA IIL GDRPGL+NV +E IQD +L+ALE L+ NHP++ LF KLLQKM D
Sbjct: 382 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 441
Query: 406 LRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
LRQ+VTEH Q++Q IKKTET+ SLHPLLQEIYKD+Y
Sbjct: 442 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 172 bits (437), Expect = 4e-43
Identities = 127/416 (30%), Positives = 204/416 (49%), Gaps = 54/416 (12%)
Query: 34 QHALPSSSYTDLS------RSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYG 87
QH LP S Y+ S +SSS ++ + C VC DK+SG+HYG
Sbjct: 45 QHQLPVSGYSTPSPATIETQSSSSEEIVPSPP---SPPPLPRIYKPCFVCQDKSSGYHYG 101
Query: 88 VHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF 145
V ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R
Sbjct: 102 VSACEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRN 160
Query: 146 GRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKA 205
R +K+K V +E P+V +L + + A+ + F + + +
Sbjct: 161 DR---NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSS 214
Query: 206 SHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAK 265
V DI+ LW + E+S +C TV EFAK
Sbjct: 215 EQR---VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAK 244
Query: 266 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKP 323
+P F++L + DQ+TLLK + + + + +D + ++G + + P
Sbjct: 245 QLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP 304
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEF 383
+D++ F FA + LE+DD++ L A ++CGDR L RV+ +Q+ +L AL+
Sbjct: 305 LTDLV---FAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
Query: 384 HLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKD 439
+++ P ++FPK+L K+ DLR + + A+ + + K E S+ PL+QE+ ++
Sbjct: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL-KMEIPGSMPPLIQEMLEN 416
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 172 bits (437), Expect = 4e-43
Identities = 124/412 (30%), Positives = 201/412 (48%), Gaps = 55/412 (13%)
Query: 32 GPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHAC 91
G H++ + S + SPPS + C VC DK+SG+HYGV AC
Sbjct: 51 GSNHSIETQSSSSEEIVPSPPS----------PPPLPRIYKPCFVCQDKSSGYHYGVSAC 100
Query: 92 EGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMP 149
EGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R R
Sbjct: 101 EGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR-- 157
Query: 150 EAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTA 209
+K+K V +E P+V +L + + A+ + F + + +
Sbjct: 158 -NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSSEQR- 212
Query: 210 PFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPS 269
V DI+ LW + E+S +C TV EFAK +P
Sbjct: 213 --VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAKQLPG 243
Query: 270 FSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKPFSDI 327
F++L + DQ+TLLK + + + + +D + ++G + + P +D+
Sbjct: 244 FTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDL 303
Query: 328 IEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQA 387
+ F FA + LE+DD++ L A ++CGDR L RV+ +Q+ +L AL+ +++
Sbjct: 304 V---FAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRK 360
Query: 388 NHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKD 439
P ++FPK+L K+ DLR + + A+ + + K E S+ PL+QE+ ++
Sbjct: 361 RRPSRPHMFPKMLMKITDLRSISAKGAERVITL-KMEIPGSMPPLIQEMLEN 411
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 172 bits (437), Expect = 4e-43
Identities = 127/416 (30%), Positives = 204/416 (49%), Gaps = 54/416 (12%)
Query: 34 QHALPSSSYTDLS------RSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYG 87
QH LP S Y+ S +SSS ++ + C VC DK+SG+HYG
Sbjct: 45 QHQLPVSGYSTPSPATIETQSSSSEEIVPSPP---SPPPLPRIYKPCFVCQDKSSGYHYG 101
Query: 88 VHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF 145
V ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R
Sbjct: 102 VSACEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRN 160
Query: 146 GRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKA 205
R +K+K V +E P+V +L + + A+ + F + + +
Sbjct: 161 DR---NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSS 214
Query: 206 SHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAK 265
V DI+ LW + E+S +C TV EFAK
Sbjct: 215 EQR---VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAK 244
Query: 266 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKP 323
+P F++L + DQ+TLLK + + + + +D + ++G + + P
Sbjct: 245 QLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP 304
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEF 383
+D++ F FA + LE+DD++ L A ++CGDR L RV+ +Q+ +L AL+
Sbjct: 305 LTDLV---FAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
Query: 384 HLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKD 439
+++ P ++FPK+L K+ DLR + + A+ + + K E S+ PL+QE+ ++
Sbjct: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL-KMEIPGSMPPLIQEMLEN 416
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 172 bits (435), Expect = 7e-43
Identities = 111/370 (30%), Positives = 184/370 (49%), Gaps = 45/370 (12%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQ 139
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS ++R R +K+K + E + ++ DL ++ I A+ + F
Sbjct: 140 KCFEVGMSKESVRNDR---NKKKKETSKQECTESYEMTAELDDL---TEKIRKAHQETFP 193
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H + LW L K ++
Sbjct: 194 SLCQLGKYTTNSSADHRVRLDL----GLWDKFSELATKCII------------------- 230
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 231 -------KIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGL 283
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPR 369
+ + P +D++ F FA + LE+DD++ L A ++CGDR L +
Sbjct: 284 TLNRTQMHNAGFGPLTDLV---FTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTK 340
Query: 370 VEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSL 429
V+ +Q+ +L AL+ +++ P ++FPK+L K+ DLR + + A+ + + K E S+
Sbjct: 341 VDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITL-KMEIPGSM 399
Query: 430 HPLLQEIYKD 439
PL+QE+ ++
Sbjct: 400 PPLIQEMLEN 409
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 168 bits (426), Expect = 8e-42
Identities = 111/370 (30%), Positives = 187/370 (50%), Gaps = 45/370 (12%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV +CEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 137
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS A+R R +K+K V + + + +PQ+ +L + A+ + F
Sbjct: 138 KCFEVGMSKEAVRNDR---NKKKKEVKEEGSPDSYELSPQLEEL---ITKVSKAHQETFP 191
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H Q + GL W + + E++
Sbjct: 192 SLCQLGKYTTNSSADHRV-----------QLDLGL-WDK-------FSELA--------- 223
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
+ + ++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 224 --TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGL 281
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPR 369
+ + P +D++ F FA + LE+DD++ L A ++CGDR L +
Sbjct: 282 TLNRTQMHNAGFGPLTDLV---FAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEK 338
Query: 370 VEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSL 429
V+ +Q+ +L AL + + P Y+FP++L K+ DLR + T+ A+ + K E +
Sbjct: 339 VDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITL-KMEIPGPM 397
Query: 430 HPLLQEIYKD 439
PL++E+ ++
Sbjct: 398 PPLIREMLEN 407
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 168 bits (426), Expect = 8e-42
Identities = 111/370 (30%), Positives = 187/370 (50%), Gaps = 45/370 (12%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV +CEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 148
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS A+R R +K+K V + + + +PQ+ +L + A+ + F
Sbjct: 149 KCFEVGMSKEAVRNDR---NKKKKEVKEEGSPDSYELSPQLEEL---ITKVSKAHQETFP 202
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H Q + GL W + + E++
Sbjct: 203 SLCQLGKYTTNSSADHRV-----------QLDLGL-WDK-------FSELA--------- 234
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
+ + ++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 235 --TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGL 292
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPR 369
+ + P +D++ F FA + LE+DD++ L A ++CGDR L +
Sbjct: 293 TLNRTQMHNAGFGPLTDLV---FAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEK 349
Query: 370 VEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSL 429
V+ +Q+ +L AL + + P Y+FP++L K+ DLR + T+ A+ + K E +
Sbjct: 350 VDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITL-KMEIPGPM 408
Query: 430 HPLLQEIYKD 439
PL++E+ ++
Sbjct: 409 PPLIREMLEN 418
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 152 bits (384), Expect = 6e-37
Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 27/374 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE---KCERSCKIQKKNRNKCQYCRF 130
C VCGDKA+G+HY CEGCKGFFRRTI+ L K E C I K RN+CQ CRF
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 131 QKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNF 190
+KC+ +GM+ + + KRKL+ E ++ + +L+ H + +
Sbjct: 167 KKCIYVGMATDLV-LDDSKRLAKRKLI------EENREKRRREELQKSIGHKPEPTDEEW 219
Query: 191 NMTKK--KARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYR 248
+ K +A + SH E + QA +VN P ++ + F
Sbjct: 220 ELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP-------IVNA-PEGGKVDLEAFSH 271
Query: 249 CQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN--KDGLLVA 306
+ + +FAK +P F L DQ+ LLK G I ++ A++ + L
Sbjct: 272 FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLK-GCCMEIMSLRAAVRYDPESETLTL 330
Query: 307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMN 366
NG VTR L++ + + F+ + ++ LDD+++AL A +++ DRPGL
Sbjct: 331 NGEMAVTRGQLKN--GGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC 388
Query: 367 VPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE 426
V R+E QD+ L A E ++ + +PKLL K+ DLR + HA + K E
Sbjct: 389 VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM-KVECP 447
Query: 427 TSLH-PLLQEIYKD 439
T L PL E+++D
Sbjct: 448 TELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 152 bits (384), Expect = 6e-37
Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 27/374 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE---KCERSCKIQKKNRNKCQYCRF 130
C VCGDKA+G+HY CEGCKGFFRRTI+ L K E C I K RN+CQ CRF
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 131 QKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNF 190
+KC+ +GM+ + + KRKL+ E ++ + +L+ H + +
Sbjct: 167 KKCIYVGMATDLV-LDDSKRLAKRKLI------EENREKRRREELQKSIGHKPEPTDEEW 219
Query: 191 NMTKK--KARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYR 248
+ K +A + SH E + QA +VN P ++ + F
Sbjct: 220 ELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP-------IVNA-PEGGKVDLEAFSH 271
Query: 249 CQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN--KDGLLVA 306
+ + +FAK +P F L DQ+ LLK G I ++ A++ + L
Sbjct: 272 FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLK-GCCMEIMSLRAAVRYDPESETLTL 330
Query: 307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMN 366
NG VTR L++ + + F+ + ++ LDD+++AL A +++ DRPGL
Sbjct: 331 NGEMAVTRGQLKN--GGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC 388
Query: 367 VPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE 426
V R+E QD+ L A E ++ + +PKLL K+ DLR + HA + K E
Sbjct: 389 VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM-KVECP 447
Query: 427 TSLH-PLLQEIYKD 439
T L PL E+++D
Sbjct: 448 TELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 152 bits (384), Expect = 6e-37
Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 27/374 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE---KCERSCKIQKKNRNKCQYCRF 130
C VCGDKA+G+HY CEGCKGFFRRTI+ L K E C I K RN+CQ CRF
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 131 QKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNF 190
+KC+ +GM+ + + KRKL+ E ++ + +L+ H + +
Sbjct: 167 KKCIYVGMATDLV-LDDSKRLAKRKLI------EENREKRRREELQKSIGHKPEPTDEEW 219
Query: 191 NMTKK--KARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYR 248
+ K +A + SH E + QA +VN P ++ + F
Sbjct: 220 ELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP-------IVNA-PEGGKVDLEAFSH 271
Query: 249 CQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN--KDGLLVA 306
+ + +FAK +P F L DQ+ LLK G I ++ A++ + L
Sbjct: 272 FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLK-GCCMEIMSLRAAVRYDPESETLTL 330
Query: 307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMN 366
NG VTR L++ + + F+ + ++ LDD+++AL A +++ DRPGL
Sbjct: 331 NGEMAVTRGQLKN--GGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC 388
Query: 367 VPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE 426
V R+E QD+ L A E ++ + +PKLL K+ DLR + HA + K E
Sbjct: 389 VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM-KVECP 447
Query: 427 TSLH-PLLQEIYKD 439
T L PL E+++D
Sbjct: 448 TELFPPLFLEVFED 461
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 150 bits (380), Expect = 2e-36
Identities = 126/414 (30%), Positives = 190/414 (45%), Gaps = 57/414 (13%)
Query: 31 GGPQHALPSSSYTDLSRSSSPPSLLDQLQMGC--DGASCGSLNMECRVCGDKASGFHYGV 88
G PQ + P + + P L L++ G C +CGD++SG HYGV
Sbjct: 90 GSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGV 149
Query: 89 HACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGR 147
++CEGCKGFF+RT+R L Y + + C I K+ RN+CQYCR+QKCLA+GM A++
Sbjct: 150 YSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQ--- 206
Query: 148 MPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASH 207
E+R+ G NE + A+ + I A L
Sbjct: 207 ----EERQ--RGKDRNENEVESTSSANEDMPVERILEAELA------------------- 241
Query: 208 TAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSI 267
V ET +A GL N P ++ CQ + + L E+AK I
Sbjct: 242 ----VEPKTETYVEANMGL------NPSSPNDPVT----NICQAAD-KQLFTLVEWAKRI 286
Query: 268 PSFSSLFLNDQVTLLKYGVHEAIFAMLA--SIVNKDGLLVANGSGFVTREFLRS--LRKP 323
P FS L L+DQV LL+ G +E + A + SI KDG+L+A G V R S +
Sbjct: 287 PHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL-HVHRNSAHSAGVGAI 345
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEF 383
F ++ E K +++D ++L A ++ D GL N VEA+++ + +LE
Sbjct: 346 FDRVLT---ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEA 402
Query: 384 HLQANHPDAQYLFPKLLQKMADLRQL---VTEHAQMMQRIKKTETETSLHPLLQ 434
+ + +P+ F KLL ++ LR + EH + I T +T L +L+
Sbjct: 403 YCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 144 bits (363), Expect = 2e-34
Identities = 132/469 (28%), Positives = 207/469 (44%), Gaps = 73/469 (15%)
Query: 4 PQEEAPEVREEEEKEEVAEAEGA-----------PELNGGPQHA-LPSSSYTDLSRSSSP 51
P + A E+ + ++ ++A+G P GG L ++ T L + P
Sbjct: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEP 72
Query: 52 PSLLDQL--QMGCDGASCGSLNME-CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEY 108
PS ++ Q G + L E C VCGDKASGFHY V +CEGCKGFFRR++ +K +
Sbjct: 73 PSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSV-IKGAH 131
Query: 109 EKCERS--CKIQKKNRNKCQYCRFQKCLALGM------SHNAIRFGRMPEAEKRKLVAGL 160
C C + R KCQ CR +KC GM S IR ++ E+ + A
Sbjct: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Query: 161 T---ANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIE 217
A+ Q PQ++ + M +K + + + F
Sbjct: 192 LPPRASSPPQILPQLSP-------------EQLGMIEKL---VAAQQQCNRRSFSDRLRV 235
Query: 218 TLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLND 277
T W P +E F + +V+E+ +FAK +P F L D
Sbjct: 236 TPWPMAPD----------PHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 285
Query: 278 QVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSL---RKPFS------DII 328
Q+ LLK E + + N GS +T FL+ R+ F+ + I
Sbjct: 286 QIALLKTSAIEVMLLETSRRYNP-------GSESIT--FLKDFSYNREDFAKAGLQVEFI 336
Query: 329 EPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQAN 388
P FEF+ N L+L+D++ AL IA I DRP + + +VE +Q T + AL ++ +
Sbjct: 337 NPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIH 396
Query: 389 HPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIY 437
HP + +FP++L K+ LR L + H++ + ++ + + L PLL EI+
Sbjct: 397 HPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKK--LPPLLSEIW 443
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 144 bits (362), Expect = 2e-34
Identities = 124/427 (29%), Positives = 191/427 (44%), Gaps = 61/427 (14%)
Query: 32 GPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNME-CRVCGDKASGFHYGVHA 90
G + A P++ T S P + Q + G + L E C VCGDKASGFHY V +
Sbjct: 12 GLEAAEPTALLTRAEPPSEPTEIRPQKRK--KGPAPKMLGNELCSVCGDKASGFHYNVLS 69
Query: 91 CEGCKGFFRRTIRMKLEYEKCERS--CKIQKKNRNKCQYCRFQKCLALGM------SHNA 142
CEGCKGFFRR++ +K + C C + R KCQ CR +KC GM S
Sbjct: 70 CEGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQ 128
Query: 143 IRFGRMPEAEKRKLVAGLT---ANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARS 199
IR ++ E+ + A A+ Q PQ++ + M +K
Sbjct: 129 IRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSP-------------EQLGMIEKL--- 172
Query: 200 ILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRE 259
+ + + F T W P +E F + +V+E
Sbjct: 173 VAAQQQCNRRSFSDRLRVTPWPMAPD----------PHSREARQQRFAHFTELAIVSVQE 222
Query: 260 LTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRS 319
+ +FAK +P F L DQ+ LLK E + + N GS +T FL+
Sbjct: 223 IVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNP-------GSESIT--FLKD 273
Query: 320 L---RKPFS------DIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRV 370
R+ F+ + I P FEF+ N L+L+D++ AL IA I DRP + + +V
Sbjct: 274 FSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQV 333
Query: 371 EAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLH 430
E +Q T + AL ++ +HP + +FP++L K+ LR L + H++ + ++ + + L
Sbjct: 334 ERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKK--LP 391
Query: 431 PLLQEIY 437
PLL EI+
Sbjct: 392 PLLSEIW 398
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 142 bits (358), Expect = 6e-34
Identities = 125/414 (30%), Positives = 183/414 (44%), Gaps = 65/414 (15%)
Query: 36 ALPSSSYTDLSRSSSP------PSLLDQLQMGCDGASCGSLNME-CRVCGDKASGFHYGV 88
A PSS ++ SS P L M S GSL C +CGD++SG HYGV
Sbjct: 94 APPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGV 153
Query: 89 HACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGR 147
++CEGCKGFF+RTIR L Y + + C I K+ RN+CQYCR+QKCL +GM A++ R
Sbjct: 154 YSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEER 213
Query: 148 MPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASH 207
E+ + A A G + P + I A L T+ + +
Sbjct: 214 QRSRERAESEAE-CATSGHEDMP--------VERILEAELAVEPKTESYGDMNMENSTND 264
Query: 208 TAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSI 267
+ H + KQL T VE +AK I
Sbjct: 265 PVTNICHAAD-----------KQLF-------------------TLVE-------WAKRI 287
Query: 268 PSFSSLFLNDQVTLLKYGVHEAIFAMLA--SIVNKDGLLVANGSGFVTREFLRS--LRKP 323
P FS L L DQV LL+ G +E + A + S+ +DG+L+A G V R S +
Sbjct: 288 PHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGL-HVHRSSAHSAGVGSI 346
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEF 383
F ++ E K +++D S+L A ++ D GL N VE +++ + LE
Sbjct: 347 FDRVLT---ELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEA 403
Query: 384 HLQANHPDAQYLFPKLLQKMADLRQL---VTEHAQMMQRIKKTETETSLHPLLQ 434
+ + +P+ F KLL ++ LR + EH + I T +T L +L+
Sbjct: 404 YTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 457
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 135 bits (339), Expect = 1e-31
Identities = 121/445 (27%), Positives = 188/445 (42%), Gaps = 70/445 (15%)
Query: 4 PQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCD 63
PQ+E P + ++A AP + G P A P + T P S Q G
Sbjct: 11 PQDEVPG-------SQGSQASQAPPVPGPPPGA-PHTPQTP--GQGGPASTPAQTAAGGQ 60
Query: 64 GASCG--------SLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE-KCERS 114
G G ++EC VCGDK+SG HYG CEGCK FF+R++R L Y + R+
Sbjct: 61 GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN 120
Query: 115 CKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVAD 174
C I + +RN+CQYCR +KCL +GM A++ GRMP + LT G N
Sbjct: 121 CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALT--NGDPLN----- 173
Query: 175 LKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNG 234
++YL + +A T + + + G
Sbjct: 174 --------CHSYLSGYISLLLRAEPYPTSRFGSQC-----------------MQPNNIMG 208
Query: 235 LPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF--- 291
+ E++ + + E+A++IP F L + DQV LL+ E
Sbjct: 209 IENICELAARMLF-----------SAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNA 257
Query: 292 AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALF 351
A + ++ LL A +G F D I E K AL +D ++ +
Sbjct: 258 AQCSMPLHVAPLLAA--AGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCL 315
Query: 352 IAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQL-- 409
A ++ D GL +V VE++Q+ ALE ++++ +P+ F KLL ++ LR +
Sbjct: 316 KAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSS 375
Query: 410 -VTEHAQMMQRIKKTETETSLHPLL 433
V E ++ + KT ET + +L
Sbjct: 376 SVIEQLFFVRLVGKTPIETLIRDML 400
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 134
Score = 112 bits (280), Expect = 7e-25
Identities = 65/166 (39%), Positives = 96/166 (57%), Gaps = 3/166 (1%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTRE 315
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQD 375
L S+ D++ FEF+ K NAL+L D +++LF A +++ DR G+ NV VEA+Q+
Sbjct: 398 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
Query: 376 TILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIK 421
T++RAL + NHP+ +F KLL K+ DLR L H++ + K
Sbjct: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 134 bits (338), Expect = 1e-31
Identities = 114/429 (26%), Positives = 185/429 (43%), Gaps = 69/429 (16%)
Query: 14 EEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNME 73
E++++ + A P+ G P P++ T + PP G+ ++E
Sbjct: 39 EQQQQAGSGAPHTPQTPGQP--GAPATPGTAGDKGQGPP-----------GSGQSQQHIE 85
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQK 132
C VCGDK+SG HYG CEGCK FF+R++R L Y + R+C I + +RN+CQYCR +K
Sbjct: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
Query: 133 CLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNM 192
CL +GM A++ GRMP + LT G N + YL +
Sbjct: 146 CLKVGMRREAVQRGRMPPTQPNPGQYALT--NGDPLNG-------------HCYLSGYIS 190
Query: 193 TKKKARSILTGK--ASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQ 250
+A T + + P I IE + + L++ +
Sbjct: 191 LLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAV------------------- 231
Query: 251 CTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF---AMLASIVNKDGLLVAN 307
E+A++IP F L + DQV+LL+ E A + ++ LL A
Sbjct: 232 -----------EWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAA- 279
Query: 308 GSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNV 367
+G F D I E K AL +D ++ + A ++ D GL +
Sbjct: 280 -AGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDA 338
Query: 368 PRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQL---VTEHAQMMQRIKKTE 424
+E++Q+ ALE ++++ +P+ F KLL ++ LR + V E ++ + KT
Sbjct: 339 AHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTP 398
Query: 425 TETSLHPLL 433
ET + +L
Sbjct: 399 IETLIRDML 407
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 209
Score = 112 bits (280), Expect = 7e-25
Identities = 65/166 (39%), Positives = 96/166 (57%), Gaps = 3/166 (1%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTRE 315
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQD 375
L S+ D++ FEF+ K NAL+L D +++LF A +++ DR G+ NV VEA+Q+
Sbjct: 473 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
Query: 376 TILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIK 421
T++RAL + NHP+ +F KLL K+ DLR L H++ + K
Sbjct: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 134 bits (337), Expect = 2e-31
Identities = 99/384 (25%), Positives = 173/384 (45%), Gaps = 52/384 (13%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTI----RMKLEYEKCERSCKIQKKNRNKCQYCR 129
CRVCGDKA+G+H+ V CEGCKGFFRR + R++ + K +C+I +K R +CQ CR
Sbjct: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK--GACEITRKTRRQCQACR 98
Query: 130 FQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQ---YNPQVADLKAFSKHIYNAY 186
+KCL GM I E + + + G+Q + + + + +A
Sbjct: 99 LRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQ 158
Query: 187 LKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVW----------KQLVNGLP 236
+K F+ T SH F + + E G VW K++ + LP
Sbjct: 159 MKTFDTT-----------FSHFKNF---RVSLQLRGEDGSVWNYKPPADSGGKEIFSLLP 204
Query: 237 PYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS 296
++S ++F + + FAK I F L + DQ++LLK E +
Sbjct: 205 HMADMSTYMF-----------KGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNT 253
Query: 297 IVNKD-GLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAI 355
+ N + G + + ++ ++EP +F L+L + + L A
Sbjct: 254 VFNAETGTWECGRLSYCLEDTAGGFQQL---LLEPMLKFHYMLKKLQLHEEEYVLMQAIS 310
Query: 356 ILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDA--QYLFPKLLQKMADLRQLVTEH 413
+ DRPG++ V+ +Q+ L+ +++ N P ++LF K++ + +LR + +H
Sbjct: 311 LFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQH 370
Query: 414 AQMMQRIKKTETETSLHPLLQEIY 437
Q + RI+ + PL+QE++
Sbjct: 371 TQRLLRIQ--DIHPFATPLMQELF 392
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 133 bits (335), Expect = 3e-31
Identities = 64/144 (44%), Positives = 94/144 (65%), Gaps = 18/144 (12%)
Query: 30 NGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGAS-------------CGSLNMECRV 76
+G P + SSS + + SPP LQ+ + +S + + C+V
Sbjct: 78 DGSPSSSSSSSSSSSSFYNGSPPG---SLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKV 134
Query: 77 CGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQKCL 134
CGD ASGFHYGVHACEGCKGFFRR+I+ ++Y++C +C I + NRN+CQ CRF+KCL
Sbjct: 135 CGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCL 194
Query: 135 ALGMSHNAIRFGRMPEAEKRKLVA 158
++GMS +A+RFGR+P+ EK++++A
Sbjct: 195 SVGMSRDAVRFGRIPKREKQRMLA 218
Score = 100 bits (250), Expect = 2e-21
Identities = 61/162 (37%), Positives = 90/162 (55%), Gaps = 3/162 (1%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN-KDGLLVANGSGFVTRE 315
VRE+ EFAK IP F L +DQVTLLK G E + AS+ N KD ++ + +
Sbjct: 447 VREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQ 506
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQD 375
L ++ D++ F+F+ K N+L L + +L LF A +++ DR G+ N VE +Q+
Sbjct: 507 ELGAMG--MGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQE 564
Query: 376 TILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMM 417
T+LRAL + N P F KLL K+ DLR L H++ +
Sbjct: 565 TLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKL 606
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 125 bits (313), Expect = 1e-28
Identities = 107/393 (27%), Positives = 171/393 (43%), Gaps = 41/393 (10%)
Query: 48 SSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLE 107
S+SPP + G + L ++C VCGDK+SG HYGV CEGCK FF+R+IR L
Sbjct: 32 SASPPGAASDAEPGDEERP--GLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLS 89
Query: 108 YE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGS 166
Y + R C+I + +RN+CQYCR +KC +GM A++ GR+P + L + A+ GS
Sbjct: 90 YTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHS----LPGAVAASSGS 145
Query: 167 QYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGL 226
+A A ++ + S L + P+ + G
Sbjct: 146 PPGSALA-----------AVASGGDLFPGQPVSELIAQLLRAEPYP----AAAGRFGAGG 190
Query: 227 VWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGV 286
V G+ E++ + + E+A+ P F L + DQV LL+
Sbjct: 191 GAAGAVLGIDNVCELAARLLF-----------STVEWARHAPFFPELPVADQVALLRLSW 239
Query: 287 HEAIF---AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
E A A ++ LL A G R++ F D + E K L++
Sbjct: 240 SELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAV--AFMDQVRAFQEQVDKLGRLQV 297
Query: 344 DDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKM 403
D ++ A + D GL + VE++Q+ AL +++A +P F +LL ++
Sbjct: 298 DSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRL 357
Query: 404 ADLRQL---VTEHAQMMQRIKKTETETSLHPLL 433
LR + + M+ + KT ET + +L
Sbjct: 358 PALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 124 bits (312), Expect = 1e-28
Identities = 122/417 (29%), Positives = 179/417 (42%), Gaps = 72/417 (17%)
Query: 38 PSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGF 97
P+S + + S P + + G G S G C VCGD AS HYGV CEGCKGF
Sbjct: 235 PTSPHLEGSGILDTPVTSTKARSGAPGGSEG----RCAVCGDNASCQHYGVRTCEGCKGF 290
Query: 98 FRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF-------GRMP 149
F+RT++ +Y + C + K+ RN+CQ+CRFQKCLA+GM +R GR+P
Sbjct: 291 FKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLP 350
Query: 150 EAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTA 209
K+ P A + A+L + T K S
Sbjct: 351 SKPKQ---------------PPDASPANLLTSLVRAHLDSGPSTAKLDYS---------- 385
Query: 210 PFVIHDIETLWQAEKGLVWKQLVNGLPPY-KEIS--VHVFYRCQCTTVETVRELTEFAKS 266
+++LV LP + KE + V FY ++E +R ++A+
Sbjct: 386 -----------------KFQELV--LPHFGKEDAGDVQQFYDLLSGSLEVIR---KWAEK 423
Query: 267 IPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSD 326
IP F+ L DQ LL+ E LA + SG V + F D
Sbjct: 424 IPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRL--QCARGFGD 481
Query: 327 IIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQ 386
I+ F+ ++L +D A ++A++L DR GL RVE +Q+ I L+ H+
Sbjct: 482 WIDSILAFSRSLHSLLVDVPAFAC-LSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540
Query: 387 --ANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI--KKTETETSLHPLLQEIYKD 439
A P +LL K+ +LR L T Q +QRI K E P++ +I+ D
Sbjct: 541 AVAGEPQPASCLSRLLGKLPELRTLCT---QGLQRIFYLKLEDLVPPPPIIDKIFMD 594
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 124 bits (312), Expect = 1e-28
Identities = 122/417 (29%), Positives = 179/417 (42%), Gaps = 72/417 (17%)
Query: 38 PSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGF 97
P+S + + S P + + G G S G C VCGD AS HYGV CEGCKGF
Sbjct: 235 PTSPHLEGSGILDTPVTSTKARSGAPGGSEG----RCAVCGDNASCQHYGVRTCEGCKGF 290
Query: 98 FRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF-------GRMP 149
F+RT++ +Y + C + K+ RN+CQ+CRFQKCLA+GM +R GR+P
Sbjct: 291 FKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLP 350
Query: 150 EAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTA 209
K+ P A + A+L + T K S
Sbjct: 351 SKPKQ---------------PPDASPANLLTSLVRAHLDSGPSTAKLDYS---------- 385
Query: 210 PFVIHDIETLWQAEKGLVWKQLVNGLPPY-KEIS--VHVFYRCQCTTVETVRELTEFAKS 266
+++LV LP + KE + V FY ++E +R ++A+
Sbjct: 386 -----------------KFQELV--LPHFGKEDAGDVQQFYDLLSGSLEVIR---KWAEK 423
Query: 267 IPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSD 326
IP F+ L DQ LL+ E LA + SG V + F D
Sbjct: 424 IPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRL--QCARGFGD 481
Query: 327 IIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQ 386
I+ F+ ++L +D A ++A++L DR GL RVE +Q+ I L+ H+
Sbjct: 482 WIDSILAFSRSLHSLLVDVPAFAC-LSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540
Query: 387 --ANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI--KKTETETSLHPLLQEIYKD 439
A P +LL K+ +LR L T Q +QRI K E P++ +I+ D
Sbjct: 541 AVAGEPQPASCLSRLLGKLPELRTLCT---QGLQRIFYLKLEDLVPPPPIIDKIFMD 594
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,013,641
Number of Sequences: 37866
Number of extensions: 760931
Number of successful extensions: 5748
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 5008
Number of HSP's gapped (non-prelim): 480
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.