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Search of human proteins with 5453860
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
(496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 991 0.0
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 991 0.0
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 716 0.0
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 603 e-172
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 603 e-172
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 596 e-170
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 375 e-104
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 353 3e-97
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 339 4e-93
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 326 3e-89
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 318 7e-87
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 317 1e-86
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 316 3e-86
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 251 1e-66
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 239 3e-63
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 237 2e-62
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 237 2e-62
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 228 7e-60
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 226 5e-59
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 218 1e-56
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 217 2e-56
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 217 2e-56
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 215 7e-56
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 215 7e-56
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 209 4e-54
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 991 bits (2562), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 60
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
Sbjct: 7 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 66
Query: 61 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 120
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
Sbjct: 67 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 126
Query: 121 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 180
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
Sbjct: 127 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 186
Query: 181 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 240
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
Sbjct: 187 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 246
Query: 241 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
Sbjct: 247 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 306
Query: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
Sbjct: 307 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 366
Query: 361 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 420
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
Sbjct: 367 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 426
Query: 421 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
Sbjct: 427 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
Query: 481 MPDSGRPAFRVVDTEF 496
MPDSGRPAFRVVDTEF
Sbjct: 487 MPDSGRPAFRVVDTEF 502
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 991 bits (2562), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 60
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
Sbjct: 1 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 60
Query: 61 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 120
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
Sbjct: 61 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 120
Query: 121 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 180
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
Sbjct: 121 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 180
Query: 181 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 240
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
Sbjct: 181 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 240
Query: 241 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
Sbjct: 241 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300
Query: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
Sbjct: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360
Query: 361 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 420
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
Sbjct: 361 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 420
Query: 421 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
Sbjct: 421 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
Query: 481 MPDSGRPAFRVVDTEF 496
MPDSGRPAFRVVDTEF
Sbjct: 481 MPDSGRPAFRVVDTEF 496
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 716 bits (1849), Expect = 0.0
Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)
Query: 4 MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 45
MKK KR+LS+TLRG + ID++ + EQ+ ++E+ G P
Sbjct: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
Query: 46 ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 93
+ P R + + G + P +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
Query: 94 QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 153
QSP V +RN R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
Query: 154 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 213
LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
Query: 214 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 273
LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
Query: 274 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 333
LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
Query: 334 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 393
LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
Query: 394 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 453
EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
Query: 454 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 485
H LP++ SIF+LKEIQLQK+ R+SS P++G
Sbjct: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 603 bits (1555), Expect = e-172
Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)
Query: 71 HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 122
+E+L++G G E S T S E SP R R+ S ED++KRLSLP
Sbjct: 42 NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101
Query: 123 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 182
DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161
Query: 183 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 242
+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221
Query: 243 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 302
LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281
Query: 303 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 362
ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341
Query: 363 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 422
PGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L++HAPRLD+DG L
Sbjct: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401
Query: 423 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 482
L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+ R +
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
Query: 483 DSGR 486
GR
Sbjct: 462 QPGR 465
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 603 bits (1555), Expect = e-172
Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)
Query: 71 HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 122
+E+L++G G E S T S E SP R R+ S ED++KRLSLP
Sbjct: 42 NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101
Query: 123 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 182
DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161
Query: 183 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 242
+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221
Query: 243 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 302
LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281
Query: 303 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 362
ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341
Query: 363 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 422
PGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L++HAPRLD+DG L
Sbjct: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401
Query: 423 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 482
L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+ R +
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
Query: 483 DSGR 486
GR
Sbjct: 462 QPGR 465
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 596 bits (1536), Expect = e-170
Identities = 304/498 (61%), Positives = 372/498 (74%), Gaps = 17/498 (3%)
Query: 1 MDRMKKIKRQLSMTLRGGRGIDKT------------NGAPEQIGLDESGGGGGSDPGEAP 48
M++MK KR+ S+++ I+++ N E + L G G DP +
Sbjct: 3 MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQL----GPLGRDPPQEC 58
Query: 49 TRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRK 108
+ +P + G LS + + E +AS +V +
Sbjct: 59 STFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEV-RASGALPRQVAGCTHKGVHRRAAAL 117
Query: 109 ISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKL 168
D++KRLSLP DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KL
Sbjct: 118 QPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKL 177
Query: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 228
DKLGEGTYATV+KG+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD
Sbjct: 178 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 237
Query: 229 IIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLK 288
+IHT++SLTLVFEYLD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLK
Sbjct: 238 LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLK 297
Query: 289 PQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGV 348
PQNLLINERGELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGV
Sbjct: 298 PQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV 357
Query: 349 GCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEAL 408
GCI YEMATGRPLFPGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L
Sbjct: 358 GCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL 417
Query: 409 LSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEI 468
++HAPRLD+DG LL+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEI
Sbjct: 418 INHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEI 477
Query: 469 QLQKEASLRSSSMPDSGR 486
QLQK+ R + GR
Sbjct: 478 QLQKDPGYRGLAFQQPGR 495
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 375 bits (963), Expect = e-104
Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)
Query: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218
FGK ++Y KL+KLGEG+YATVYKGKSK+ LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
Query: 219 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278
KHANIV LHDIIHT+++LTLVFEY+ DL QY+D ++ NVKLFLFQLLRGL+Y H
Sbjct: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
Query: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
Query: 339 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 397
YST +DMWGVGCIF EM G FPG +++QL IF +LGTP E+TWPG+ S FK
Sbjct: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
Query: 398 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 455
+ Y ++ L +L + DL +KLLQ +NR+SA+ A+ H +F L R+ +
Sbjct: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
Query: 456 LPDTTSIFALKEIQLQKEA 474
L D +SIF + ++LQ EA
Sbjct: 411 LTDMSSIFTVPNVRLQPEA 429
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 353 bits (905), Expect = 3e-97
Identities = 180/333 (54%), Positives = 240/333 (72%), Gaps = 3/333 (0%)
Query: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218
FG +Y+ L+KLGEG+YATVYKG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
Query: 219 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278
KHANIV LHDIIHT+++LT VFEY+ DL QY+ ++ HNV+LF+FQLLRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
Query: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
Q VLHRDLKPQNLLI+ GELKLADFGLARAKSIP++TYS+EVVTLWYRPPD LLG+T+
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Query: 339 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGI--LSNEEF 395
YS+++D+WG GCIF EM G+PLFPG S + EQL I+ +LG PTE+TWPG+ L N
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Query: 396 KTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 455
+ + P R+ ++ + + DL +++L+ R+R+SA++A+ H +F +L ++++
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
Query: 456 LPDTTSIFALKEIQLQKEASLRSSSMPDSGRPA 488
LPD S+F + ++L+ E +S PA
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHHPA 378
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 339 bits (869), Expect = 4e-93
Identities = 167/288 (57%), Positives = 216/288 (75%), Gaps = 5/288 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
++ Y KL+K+GEGTY TV+K K++ T +VALK +RL+ + EG P +A+RE+ LLK+LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 280
NIV LHD++H++K LTLVFE+ D+DLK+Y D C ++ VK FLFQLL+GL +CH +
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 281 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 340
VLHRDLKPQNLLIN GELKLADFGLARA IP + YS EVVTLWYRPPD+L G+ YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 341 TQIDMWGVGCIFYEMA-TGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399
T IDMW GCIF E+A GRPLFPG+ V++QL IFR+LGTPTEE WP + ++K
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-- 238
Query: 400 YPKYRA-EALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
YP Y A +L++ P+L++ G DLL LL+ RISAE+A++HP+F
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 326 bits (835), Expect = 3e-89
Identities = 157/289 (54%), Positives = 219/289 (75%), Gaps = 3/289 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
++ + K++K+GEGTY VYK K++ T LVALK+IRL+ E EG P TAIRE+SLLK+LKH
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC-GNIINMHNVKLFLFQLLRGLAYCHR 279
NIV L D++H E+ L LVFE+L +DLK+Y+D G+ + +H +K +LFQLL+G+++CH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339
+V+HRDLKPQNLLINE G +KLADFGLARA +P +TY++EVVTLWYR P+ILLGS Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399
+T +D+W +GCIF EM T + LFPG + +QL IFR+LGTP+E+TWPG+ ++K +
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239
Query: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 448
+PK+ + L P L+ +G DLL +LLQ++ RI+A+ A+ HP+F S
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 318 bits (815), Expect = 7e-87
Identities = 154/298 (51%), Positives = 216/298 (72%), Gaps = 4/298 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 220
+E Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 278
NIV+L D++ + L L+FE+L DLK+YLD G ++ VK +L+Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
++VLHRDLKPQNLLI+++G +KLADFGLARA IP + Y++EVVTLWYR P++LLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 339 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 398
YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 399 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 456
+PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 317 bits (813), Expect = 1e-86
Identities = 159/287 (55%), Positives = 208/287 (72%), Gaps = 3/287 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
+E + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 279
NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339
+VLHRDLKPQNLLIN G +KLADFGLARA +P +TY++EVVTLWYR P+ILLG Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399
ST +D+W +GCIF EM T R LFPG + +QL IFR LGTP E WPG+ S ++K +
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
Query: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
+PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 316 bits (810), Expect = 3e-86
Identities = 152/298 (51%), Positives = 215/298 (72%), Gaps = 4/298 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 220
+E Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 278
NIV+L D++ + L L+FE+L DLK+YLD G ++ VK +L+Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
++VLHRDLKPQNLLI+++G +KLADFGLARA IP + Y++E +TLWYR P++LLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 339 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 398
YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 399 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 456
+PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 251 bits (641), Expect = 1e-66
Identities = 137/287 (47%), Positives = 182/287 (63%), Gaps = 37/287 (12%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
+E + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 279
NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339
+VLHRDLKPQNLLIN G +KLADFGLARA +P +TY++EV
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
Query: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399
T R LFPG + +QL IFR LGTP E WPG+ S ++K +
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
Query: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
+PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 252
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 333
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 334 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 392
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 393 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 450
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 451 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 510
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 511 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 570
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 571 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 630
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 631 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 690
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 691 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 728
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 401
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 402 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 459
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 460 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 519
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 520 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 579
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 580 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 639
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 640 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 699
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 700 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 737
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 251 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 310
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 311 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 369
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 370 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 427
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 428 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 487
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 488 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 547
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 548 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 607
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 608 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 667
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 668 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 705
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 29 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 88
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 89 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 147
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 148 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 205
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 206 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 265
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 266 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 325
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 326 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 385
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 386 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 445
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 446 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 483
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 239 bits (611), Expect = 3e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 285 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 344
Query: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 345 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 403
Query: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 404 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 461
Query: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 462 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 521
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 522 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 581
Query: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 582 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 641
Query: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 642 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 701
Query: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
ED +KH +F R LP S+F + +++ R +S
Sbjct: 702 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 739
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 237 bits (604), Expect = 2e-62
Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
Query: 95 SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 144
S R + + S D + S A+ + EG + LT + D P
Sbjct: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392
Query: 145 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 203
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E EG
Sbjct: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452
Query: 204 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 261
P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
Query: 262 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 321
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+
Sbjct: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572
Query: 322 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 381
VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++ +Q++ +F+ LGTP
Sbjct: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632
Query: 382 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 440
+E+ WPG K + ++ L L SD G DL+ K L + RISAED
Sbjct: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692
Query: 441 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
+KH +F R LP S+F + +++ R +S
Sbjct: 693 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 727
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 237 bits (604), Expect = 2e-62
Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)
Query: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342
Query: 95 SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 144
S R + + S D + S A+ + EG + LT + D P
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 402
Query: 145 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 203
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E EG
Sbjct: 403 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 462
Query: 204 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 261
P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 463 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 522
Query: 262 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 321
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+
Sbjct: 523 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 582
Query: 322 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 381
VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++ +Q++ +F+ LGTP
Sbjct: 583 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 642
Query: 382 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 440
+E+ WPG K + ++ L L SD G DL+ K L + RISAED
Sbjct: 643 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 702
Query: 441 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
+KH +F R LP S+F + +++ R +S
Sbjct: 703 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 737
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 228 bits (582), Expect = 7e-60
Identities = 119/291 (40%), Positives = 180/291 (61%), Gaps = 8/291 (2%)
Query: 161 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH----EEGAPCTAIREVSLLK 216
+ + Y KLD LGEG +ATVYK + K T+ +VA+K+I+L H ++G TA+RE+ LL+
Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 217 DLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY 276
+L H NI+ L D + +++LVF++++ DL+ + D ++ ++K ++ L+GL Y
Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 277 CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGS 336
H+ +LHRDLKP NLL++E G LKLADFGLA++ P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 337 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 396
Y +DMW VGCI E+ P PG + +QL IF LGTPTEE WP + S ++
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247
Query: 397 TY-NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
T+ ++P + S A D DL+ L F RI+A A+K +F
Sbjct: 248 TFKSFPGIPLHHIFSAA---GDDLLDLIQGLFLFNPCARITATQALKMKYF 295
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 226 bits (575), Expect = 5e-59
Identities = 118/289 (40%), Positives = 177/289 (61%), Gaps = 5/289 (1%)
Query: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
++ + KL+++GEGTY VY+ + TD +VALK++R++ E +G P +++RE++LL L+H
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 221 ANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 277
NIV L +++ H E S+ LV Y ++DL L++ + VK + Q+LRGL Y
Sbjct: 96 PNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYL 154
Query: 278 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGST 337
HR ++HRDLK NLL+ ++G +K ADFGLARA +P K + +VVTLWYR P++LLG+T
Sbjct: 155 HRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTT 214
Query: 338 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 397
+T IDMW VGCI E+ RPL PG++ Q+ I ++LGTP+E WPG
Sbjct: 215 TQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQ 274
Query: 398 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
Y+ K L P L G LL L ++ + R +A D ++ +F
Sbjct: 275 YSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF 323
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 218 bits (555), Expect = 1e-56
Identities = 123/303 (40%), Positives = 176/303 (58%), Gaps = 15/303 (4%)
Query: 161 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLK 219
++ Y KL K+G+GT+ V+K + + T VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74
Query: 220 HANIVTLHDIIHTEKS--------LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271
H N+V L +I T+ S + LVF++ + DL L + + +K + LL
Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134
Query: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT----YSNEVVTLWY 327
GL Y HR K+LHRD+K N+LI G LKLADFGLARA S+ + Y+N VVTLWY
Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194
Query: 328 RPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 387
RPP++LLG DY ID+WG GCI EM T P+ G+T + QL I ++ G+ T E WP
Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254
Query: 388 GILSNEEFKTYNYPKYRAEALLSH--APRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 445
+ + E ++ K + + A D DL+ KLL + RI ++DA+ H F
Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314
Query: 446 FLS 448
F S
Sbjct: 315 FWS 317
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 217 bits (553), Expect = 2e-56
Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)
Query: 105 PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 162
PP +D++K PE L+S K R +I +GK +
Sbjct: 652 PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
Query: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 221
+ + + +GEGTY VYK + K T +VALK++RL++E EG P TAIRE+ +L+ L H
Sbjct: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
Query: 222 NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271
+I+ + +I+ ++ + LVFEY+D DL L+ N +++K F+ QL+
Sbjct: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
Query: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 330
GL YCH++ LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP
Sbjct: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
Query: 331 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 390
++LLG Y+ ID+W GCI E+ T +P+F + QL I RI G+P WP ++
Sbjct: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
Query: 391 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 450
F T K L + + DL +L + R +AE A++ F +
Sbjct: 943 KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
Query: 451 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 483
PD E+ +K + M D
Sbjct: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 217 bits (553), Expect = 2e-56
Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)
Query: 105 PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 162
PP +D++K PE L+S K R +I +GK +
Sbjct: 652 PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
Query: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 221
+ + + +GEGTY VYK + K T +VALK++RL++E EG P TAIRE+ +L+ L H
Sbjct: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
Query: 222 NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271
+I+ + +I+ ++ + LVFEY+D DL L+ N +++K F+ QL+
Sbjct: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
Query: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 330
GL YCH++ LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP
Sbjct: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
Query: 331 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 390
++LLG Y+ ID+W GCI E+ T +P+F + QL I RI G+P WP ++
Sbjct: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
Query: 391 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 450
F T K L + + DL +L + R +AE A++ F +
Sbjct: 943 KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
Query: 451 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 483
PD E+ +K + M D
Sbjct: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 215 bits (548), Expect = 7e-56
Identities = 118/308 (38%), Positives = 177/308 (57%), Gaps = 12/308 (3%)
Query: 150 RRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTA 208
RR + S+ G ++ + + +GEGTY VYK K K T LVALK++RL++E EG P TA
Sbjct: 712 RRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 771
Query: 209 IREVSLLKDLKHANIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNII 258
IRE+ +L+ L H ++V + +I+ ++ + LVFEY+D DL L+
Sbjct: 772 IREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 831
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKT 317
+ ++K F+ QL+ GL YCH++ LHRD+K N+L+N G++KLADFGLAR S ++
Sbjct: 832 SEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP 891
Query: 318 YSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRI 377
Y+N+V+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + QL I R+
Sbjct: 892 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 951
Query: 378 LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISA 437
G+P WP ++ F T K L + S DLL +L + R +A
Sbjct: 952 CGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTA 1011
Query: 438 EDAMKHPF 445
E ++ F
Sbjct: 1012 EQTLQSDF 1019
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 215 bits (548), Expect = 7e-56
Identities = 118/308 (38%), Positives = 177/308 (57%), Gaps = 12/308 (3%)
Query: 150 RRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTA 208
RR + S+ G ++ + + +GEGTY VYK K K T LVALK++RL++E EG P TA
Sbjct: 712 RRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 771
Query: 209 IREVSLLKDLKHANIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNII 258
IRE+ +L+ L H ++V + +I+ ++ + LVFEY+D DL L+
Sbjct: 772 IREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 831
Query: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKT 317
+ ++K F+ QL+ GL YCH++ LHRD+K N+L+N G++KLADFGLAR S ++
Sbjct: 832 SEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP 891
Query: 318 YSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRI 377
Y+N+V+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + QL I R+
Sbjct: 892 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 951
Query: 378 LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISA 437
G+P WP ++ F T K L + S DLL +L + R +A
Sbjct: 952 CGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTA 1011
Query: 438 EDAMKHPF 445
E ++ F
Sbjct: 1012 EQTLQSDF 1019
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 209 bits (533), Expect = 4e-54
Identities = 127/300 (42%), Positives = 177/300 (59%), Gaps = 20/300 (6%)
Query: 163 ETYIKLDKLGEGTYATVYKGKS-KLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLK- 219
+ Y + ++GEG Y V+K + K VALK +R++ EEG P + IREV++L+ L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 220 --HANIVTLHDIIHT-----EKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 271
H N+V L D+ E LTLVFE++D+DL YLD + +K +FQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPD 331
RGL + H +V+HRDLKPQN+L+ G++KLADFGLAR S ++ VVTLWYR P+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189
Query: 332 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPG--I 389
+LL S+ Y+T +D+W VGCIF EM +PLF GS+ +QL I ++G P EE WP
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248
Query: 390 LSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 449
L + F + + A+ + +D G DLL K L F RISA A+ HP+F L
Sbjct: 249 LPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,402,152
Number of Sequences: 37866
Number of extensions: 954933
Number of successful extensions: 6121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 3715
Number of HSP's gapped (non-prelim): 1157
length of query: 496
length of database: 18,247,518
effective HSP length: 106
effective length of query: 390
effective length of database: 14,233,722
effective search space: 5551151580
effective search space used: 5551151580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.