Search of human proteins with 5453652

Search of human proteins with 5453652

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
         (317 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]        693   0.0  
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]        693   0.0  
gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]   232   3e-61
gi|54873613 agrin [Homo sapiens]                                      122   4e-28
gi|5901956 follistatin-like 1 precursor [Homo sapiens]                 74   2e-13
gi|12383051 transmembrane protein with EGF-like and two follista...    70   3e-12
gi|29568105 transmembrane protein with EGF-like and two follista...    69   5e-12
gi|93102379 low density lipoprotein-related protein 1B precursor...    61   1e-09
gi|190194423 SPARC-like 1 [Homo sapiens]                               53   3e-07
gi|190341024 SPARC-like 1 [Homo sapiens]                               53   3e-07
gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]      52   9e-07
gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]     51   1e-06
gi|54792136 follistatin-like 4 [Homo sapiens]                          48   1e-05
gi|190358524 follistatin-like 5 isoform c [Homo sapiens]               48   1e-05
gi|190358522 follistatin-like 5 isoform b [Homo sapiens]               48   1e-05
gi|190358520 follistatin-like 5 isoform a [Homo sapiens]               48   1e-05
gi|148833508 notch1 preproprotein [Homo sapiens]                       46   4e-05
gi|28212222 WFIKKN2 protein [Homo sapiens]                             45   8e-05
gi|78190498 secreted modular calcium-binding protein 1 isoform 1...    45   8e-05
gi|11545873 secreted modular calcium-binding protein 1 isoform 2...    45   8e-05
gi|154759249 keratin associated protein 10-11 [Homo sapiens]           44   1e-04
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...    44   2e-04
gi|93141003 testican 3 isoform 1 [Homo sapiens]                        44   2e-04
gi|93141001 testican 3 isoform 2 [Homo sapiens]                        44   2e-04
gi|7657453 serine peptidase inhibitor, Kazal type 4 [Homo sapiens]     44   2e-04
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]    43   4e-04
gi|7662036 sparc/osteonectin, cwcv and kazal-like domains proteo...    43   4e-04
gi|189163504 serine peptidase inhibitor, Kazal type 5 isoform c ...    42   5e-04
gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b p...    42   5e-04
gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a ...    42   5e-04

>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
          Length = 317

 Score =  693 bits (1788), Expect = 0.0
 Identities = 317/317 (100%), Positives = 317/317 (100%)

Query: 1   MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR 60
           MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR
Sbjct: 1   MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR 60

Query: 61  LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP 120
           LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP
Sbjct: 61  LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP 120

Query: 121 DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV 180
           DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV
Sbjct: 121 DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV 180

Query: 181 VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI 240
           VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI
Sbjct: 181 VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI 240

Query: 241 KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA 300
           KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA
Sbjct: 241 KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA 300

Query: 301 ACSSGVLLEVKHSGSCN 317
           ACSSGVLLEVKHSGSCN
Sbjct: 301 ACSSGVLLEVKHSGSCN 317


>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
          Length = 344

 Score =  693 bits (1788), Expect = 0.0
 Identities = 317/317 (100%), Positives = 317/317 (100%)

Query: 1   MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR 60
           MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR
Sbjct: 1   MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGR 60

Query: 61  LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP 120
           LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP
Sbjct: 61  LSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAP 120

Query: 121 DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV 180
           DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV
Sbjct: 121 DCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCV 180

Query: 181 VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI 240
           VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI
Sbjct: 181 VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCI 240

Query: 241 KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA 300
           KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA
Sbjct: 241 KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA 300

Query: 301 ACSSGVLLEVKHSGSCN 317
           ACSSGVLLEVKHSGSCN
Sbjct: 301 ACSSGVLLEVKHSGSCN 317



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 32/85 (37%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 88  CIPCKETCENVDCGPGKKCRMN-KKNKPRC-VCAPDCSNITWKGPVCGLDGKTYRNECAL 145
           CI  K +CE++ C  GKKC  + K  + RC +C   C +     PVC  D  TY +ECA+
Sbjct: 239 CIKAK-SCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAM 297

Query: 146 LKARCKEQPELEVQYQGRCKKTCRD 170
            +A C     LEV++ G C     D
Sbjct: 298 KEAACSSGVLLEVKHSGSCNSISED 322


>gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]
          Length = 263

 Score =  232 bits (592), Expect = 3e-61
 Identities = 102/214 (47%), Positives = 144/214 (67%), Gaps = 4/214 (1%)

Query: 27  AQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAP 86
           A  G CWL+Q +   C ++ +T++++ ECC++G + T+W+      N +   ++   G  
Sbjct: 33  APGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKIN--LLGFLGLV 90

Query: 87  NCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALL 146
           +C+PCK++C+ V+CGPGK CRM    +PRC CAPDCS +  +  VCG DG TYR+EC L 
Sbjct: 91  HCLPCKDSCDGVECGPGKACRM-LGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELR 149

Query: 147 KARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI-CPEPASSEQY 205
            ARC+  P+L V Y+GRC+K+C  V CP   +CVVDQT +A+CV C    CP P+S  Q 
Sbjct: 150 AARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQE 209

Query: 206 LCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
           LCGN+ VTY S+CH+R+ATC LGRSIG+ + G C
Sbjct: 210 LCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSC 243



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 53/157 (33%), Positives = 79/157 (50%), Gaps = 12/157 (7%)

Query: 164 CKKTCRDVFC-PGSSTCVVDQTNNAYCVT-CNRICPEPASSEQYLCGNDGVTYSSACHLR 221
           CK +C  V C PG +  ++       C   C+ +   PA  +  +CG+DG TY   C LR
Sbjct: 95  CKDSCDGVECGPGKACRMLGGRPRCECAPDCSGL---PARLQ--VCGSDGATYRDECELR 149

Query: 222 KATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDEL-CP-DSKS 279
            A C     + + Y G+C   KSCE + C   + C+ D + G   C +C    CP  S  
Sbjct: 150 AARCRGHPDLSVMYRGRC--RKSCEHVVCPRPQSCVVD-QTGSAHCVVCRAAPCPVPSSP 206

Query: 280 DEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
            + +C ++N TY S C M++A C  G  + V+H+GSC
Sbjct: 207 GQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSC 243



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 3/80 (3%)

Query: 91  CKETCENVDCGPGKKCRMNKKNKPRCVC--APDCSNITWKGP-VCGLDGKTYRNECALLK 147
           C+++CE+V C   + C +++     CV   A  C   +  G  +CG +  TY + C + +
Sbjct: 167 CRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQ 226

Query: 148 ARCKEQPELEVQYQGRCKKT 167
           A C     + V++ G C  T
Sbjct: 227 ATCFLGRSIGVRHAGSCAGT 246


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score =  122 bits (306), Expect = 4e-28
 Identities = 84/231 (36%), Positives = 104/231 (45%), Gaps = 31/231 (13%)

Query: 100 CGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQ 159
           CG  +   + +    RCVC  +C  +    PVCG DG TY +EC L    C  Q  L V 
Sbjct: 537 CGQCRFGALCEAETGRCVCPSEC--VALAQPVCGSDGHTYPSECMLHVHACTHQISLHVA 594

Query: 160 YQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACH 219
             G C+ TC D  C   + C   Q     C  C    P P      +CG+DGVTY SAC 
Sbjct: 595 SAGPCE-TCGDAVCAFGAVCSAGQ---CVCPRCEHPPPGP------VCGSDGVTYGSACE 644

Query: 220 LRKATCLLGRSIGLAYEGKCIKAK------------SCEDIQC--TGGKKCLWDFKVGRG 265
           LR+A CL    I  A  G C +A+             CE   C   GG   +WD     G
Sbjct: 645 LREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGG---IWDEDSEDG 701

Query: 266 RCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
            C +CD  C  S    PVC SD  TY++EC +K+A C S   L V   G+C
Sbjct: 702 PC-VCDFSC-QSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGAC 750



 Score =  120 bits (300), Expect = 2e-27
 Identities = 80/233 (34%), Positives = 111/233 (47%), Gaps = 33/233 (14%)

Query: 95  CENVDCGPGKKCRMN-----KKNKPRCVCAPDCSNITWKG---PVCGLDGKTYRNECALL 146
           C+  D  P + CR N     ++ +PRC     C  +T  G   PVC  DG+TY ++C   
Sbjct: 389 CQGRDQCP-EPCRFNAVCLSRRGRPRC----SCDRVTCDGAYRPVCAQDGRTYDSDCWRQ 443

Query: 147 KARCKEQPELEVQYQGRCKKT---CRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSE 203
           +A C++Q  +  ++QG C +    C  V C   +TC V   N      C + C   +S  
Sbjct: 444 QAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVK--NGQAACECLQAC---SSLY 498

Query: 204 QYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVG 263
             +CG+DGVTY SAC L    C LGR I +A +G C +       QC  G  C    +  
Sbjct: 499 DPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCG-----QCRFGALC----EAE 549

Query: 264 RGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
            GRC +C   C      +PVC SD  TY SEC +   AC+  + L V  +G C
Sbjct: 550 TGRC-VCPSEC--VALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPC 599



 Score =  114 bits (284), Expect = 1e-25
 Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 18/231 (7%)

Query: 93  ETCENVDCGPGKKCRMNKKNKPR--CVCAPD-CSNITWKGPVCGLDGKTYRNECALLKAR 149
           + C  + CG G  C  N +   R  CVC    C ++    PVCG D  TY NEC L +A+
Sbjct: 170 DACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVV--APVCGSDASTYSNECELQRAQ 227

Query: 150 CKEQPELEVQYQGRC--KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEP--ASSEQY 205
           C +Q  + +  +G C  +  C +V C   STC      +A  +T + +CP     + E  
Sbjct: 228 CSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTC----ARSADGLTASCLCPATCRGAPEGT 283

Query: 206 LCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRG 265
           +CG+DG  Y   C L +  C    ++   ++G C     C+       + C  + +  R 
Sbjct: 284 VCGSDGADYPGECQLLRRACARQENVFKKFDGPC---DPCQGALPDPSRSCRVNPRTRRP 340

Query: 266 RCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
              L  E CP  ++  PVC  D  TY ++C M  +  + G+LL+   SG C
Sbjct: 341 EMLLRPESCPARQA--PVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQC 389



 Score =  105 bits (261), Expect = 7e-23
 Identities = 71/232 (30%), Positives = 104/232 (44%), Gaps = 14/232 (6%)

Query: 90  PC--KETCENVDCGPGKKCRMNKKN-KPRCVCAPDCSNITWKGPVCGLDGKTYRNECALL 146
           PC  ++ C NV C  G  C  +       C+C   C     +G VCG DG  Y  EC LL
Sbjct: 241 PCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAP-EGTVCGSDGADYPGECQLL 299

Query: 147 KARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVD-QTNNAYCVTCNRICPEPASSEQY 205
           +  C  Q  +  ++ G C   C+      S +C V+ +T     +     CP   + +  
Sbjct: 300 RRACARQENVFKKFDGPC-DPCQGALPDPSRSCRVNPRTRRPEMLLRPESCP---ARQAP 355

Query: 206 LCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRG 265
           +CG+DGVTY + C + ++    G  +     G+C     C +  C     CL   + GR 
Sbjct: 356 VCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPE-PCRFNAVCL--SRRGRP 412

Query: 266 RCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN 317
           RCS CD +  D  +  PVCA D  TY S+C  ++A C     +  KH G C+
Sbjct: 413 RCS-CDRVTCDG-AYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCD 462



 Score =  102 bits (254), Expect = 4e-22
 Identities = 72/238 (30%), Positives = 110/238 (46%), Gaps = 28/238 (11%)

Query: 90  PCKETCENVDCGPGKKCRMNKKNK-PRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKA 148
           PC + C+     P + CR+N + + P  +  P+ S    + PVCG DG TY N+C + ++
Sbjct: 316 PC-DPCQGALPDPSRSCRVNPRTRRPEMLLRPE-SCPARQAPVCGDDGVTYENDCVMGRS 373

Query: 149 RCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVT--------CNRICPEPA 200
                  L+    G+C+         G   C      NA C++        C+R+  + A
Sbjct: 374 GAARGLLLQKVRSGQCQ---------GRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGA 424

Query: 201 SSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKS-CEDIQCTGGKKCLWD 259
                +C  DG TY S C  ++A C   R+I   ++G C +A S C  +QC  G  C   
Sbjct: 425 YRP--VCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCA-- 480

Query: 260 FKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN 317
            K G+  C  C + C  S   +PVC SD  TY S C ++  AC+ G  ++V   G C+
Sbjct: 481 VKNGQAACE-CLQAC--SSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCD 535



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 53/164 (32%), Positives = 73/164 (44%), Gaps = 25/164 (15%)

Query: 90  PCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKAR 149
           PC ETC +  C  G  C   +   PRC   P        GPVCG DG TY + C L +A 
Sbjct: 598 PC-ETCGDAVCAFGAVCSAGQCVCPRCEHPP-------PGPVCGSDGVTYGSACELREAA 649

Query: 150 CKEQPELEVQYQGRCKKT--------------CRDVFCPGSSTCVVDQTNNAYCVTCNRI 195
           C +Q ++E    G C++               C    C        + + +  CV C+  
Sbjct: 650 CLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCV-CDFS 708

Query: 196 CPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
           C     S   +CG+DGVTYS+ C L+KA C   R + +A +G C
Sbjct: 709 CQSVPGSP--VCGSDGVTYSTECELKKARCESQRGLYVAAQGAC 750



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 74/311 (23%), Positives = 110/311 (35%), Gaps = 94/311 (30%)

Query: 95  CENVDCGPG------------KKCRM-------NKKNKPRCVCAPDCSNITWKGPVCGLD 135
           CE  +CG G            + CR        + ++ P CVC   C ++    PVCG D
Sbjct: 664 CEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGP-CVCDFSCQSVPGS-PVCGSD 721

Query: 136 GKTYRNECALLKARCKEQPELEVQYQGRCK--------------------KTCRD----- 170
           G TY  EC L KARC+ Q  L V  QG C+                      C+D     
Sbjct: 722 GVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAA 781

Query: 171 -----VFCPGSSTCVVDQTNNAYC---------------VTCNRICPEPASSEQYLC-GN 209
                  CP +  C    +    C               + C+R  P   +    +  G 
Sbjct: 782 RGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGR 841

Query: 210 DGVTYSSA---------CHLRKATC-----LLGRSIGLAYEGKCIKAKSCE--------- 246
            G T  S          C      C     + G   G   +G+ +    CE         
Sbjct: 842 SGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATC 901

Query: 247 -DIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSG 305
            +++C  G +C+ +   G   C      CP++ + + VC SD  TY +EC +K  AC  G
Sbjct: 902 AEMRCEFGARCVEE--SGSAHCVCPMLTCPEANATK-VCGSDGVTYGNECQLKTIACRQG 958

Query: 306 VLLEVKHSGSC 316
           + + ++  G C
Sbjct: 959 LQISIQSLGPC 969



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 47/155 (30%), Positives = 66/155 (42%), Gaps = 13/155 (8%)

Query: 168 CRDVFCPGSSTCV--VDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATC 225
           CR + C   + C    +    A CV     CP   +    +CG+D  TYS+ C L++A C
Sbjct: 172 CRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAP---VCGSDASTYSNECELQRAQC 228

Query: 226 LLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEP--- 282
              R I L   G C     C ++ C+ G  C    +   G  + C  LCP +    P   
Sbjct: 229 SQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCA---RSADGLTASC--LCPATCRGAPEGT 283

Query: 283 VCASDNATYASECAMKEAACSSGVLLEVKHSGSCN 317
           VC SD A Y  EC +   AC+    +  K  G C+
Sbjct: 284 VCGSDGADYPGECQLLRRACARQENVFKKFDGPCD 318



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 47/166 (28%), Positives = 70/166 (42%), Gaps = 32/166 (19%)

Query: 80  IFNGGAPNCIPCKETCENVDCGPGKKCRMN-KKNKPRCVCAPDCSNITWKGPVCGL--DG 136
           I   G   C PC        C P    R + ++    C C P  +     GP CG   DG
Sbjct: 836 IVTDGRSGCTPCS-------CDPQGAVRDDCEQMTGLCSCKPGVA-----GPKCGQCPDG 883

Query: 137 KTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRIC 196
           +      AL  A C+               TC ++ C   + CV +++ +A+CV     C
Sbjct: 884 R------ALGPAGCEADASAPA--------TCAEMRCEFGARCV-EESGSAHCVCPMLTC 928

Query: 197 PEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKA 242
           PE  +++  +CG+DGVTY + C L+   C  G  I +   G C +A
Sbjct: 929 PEANATK--VCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEA 972



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 1/88 (1%)

Query: 94  TCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQ 153
           TC  + C  G +C + +     CVC            VCG DG TY NEC L    C++ 
Sbjct: 900 TCAEMRCEFGARC-VEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQG 958

Query: 154 PELEVQYQGRCKKTCRDVFCPGSSTCVV 181
            ++ +Q  G C++       P S++  V
Sbjct: 959 LQISIQSLGPCQEAVAPSTHPTSASVTV 986


>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
          Length = 308

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 35/91 (38%), Positives = 50/91 (54%), Gaps = 4/91 (4%)

Query: 95  CENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQP 154
           C NV CG G++C + +K +P C+C   C     K PVCG +GKTY N C L +  C    
Sbjct: 31  CANVFCGAGRECAVTEKGEPTCLCIEQCK--PHKRPVCGSNGKTYLNHCELHRDACLTGS 88

Query: 155 ELEVQYQGRCKKTCRDVFCPGSSTCVVDQTN 185
           +++V Y G CK+  +    P +S  V  Q+N
Sbjct: 89  KIQVDYDGHCKE--KKSVSPSASPVVCYQSN 117



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 166 KTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATC 225
           K C +VFC     C V +     C+   +  P     ++ +CG++G TY + C L +  C
Sbjct: 29  KICANVFCGAGRECAVTEKGEPTCLCIEQCKPH----KRPVCGSNGKTYLNHCELHRDAC 84

Query: 226 LLGRSIGLAYEGKCIKAKS 244
           L G  I + Y+G C + KS
Sbjct: 85  LTGSKIQVDYDGHCKEKKS 103



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 4/76 (5%)

Query: 241 KAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEA 300
           K+K C ++ C  G++C    K G   C LC E C   K   PVC S+  TY + C +   
Sbjct: 27  KSKICANVFCGAGRECAVTEK-GEPTC-LCIEQCKPHK--RPVCGSNGKTYLNHCELHRD 82

Query: 301 ACSSGVLLEVKHSGSC 316
           AC +G  ++V + G C
Sbjct: 83  ACLTGSKIQVDYDGHC 98


>gi|12383051 transmembrane protein with EGF-like and two
           follistatin-like domains 2 [Homo sapiens]
          Length = 374

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 45/145 (31%), Positives = 70/145 (48%), Gaps = 27/145 (18%)

Query: 116 CVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC----------- 164
           CVC   C+N     PVCG +G++Y+NEC L +A CK+Q E+ V  +G C           
Sbjct: 89  CVCQFKCNNDYV--PVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDG 146

Query: 165 ----------KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTY 214
                     K+T     C   + C  D   + +CV CN  C +  ++   LC +DG +Y
Sbjct: 147 VHEGSGETSQKETSTCDICQFGAECDED-AEDVWCV-CNIDCSQ--TNFNPLCASDGKSY 202

Query: 215 SSACHLRKATCLLGRSIGLAYEGKC 239
            +AC +++A+C     I +   G+C
Sbjct: 203 DNACQIKEASCQKQEKIEVMSLGRC 227



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 45/168 (26%), Positives = 71/168 (42%), Gaps = 26/168 (15%)

Query: 170 DVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQY-LCGNDGVTYSSACHLRKATCLLG 228
           D+F   ++TC  D        T   +C    +++   +CG++G +Y + C+LR+A C   
Sbjct: 65  DLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQ 124

Query: 229 RSIGLAYEGKCI--------------------KAKSCEDIQCTGGKKCLWDFKVGRGRCS 268
             I +  EG C                     K  S  DI C  G +C  D         
Sbjct: 125 SEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDI-CQFGAECDED---AEDVWC 180

Query: 269 LCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           +C+  C  +  + P+CASD  +Y + C +KEA+C     +EV   G C
Sbjct: 181 VCNIDCSQTNFN-PLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC 227



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 28/74 (37%), Positives = 42/74 (56%), Gaps = 2/74 (2%)

Query: 92  KETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCK 151
           KET     C  G +C  + ++   CVC  DCS   +  P+C  DGK+Y N C + +A C+
Sbjct: 157 KETSTCDICQFGAECDEDAEDV-WCVCNIDCSQTNFN-PLCASDGKSYDNACQIKEASCQ 214

Query: 152 EQPELEVQYQGRCK 165
           +Q ++EV   GRC+
Sbjct: 215 KQEKIEVMSLGRCQ 228


>gi|29568105 transmembrane protein with EGF-like and two
           follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 54/187 (28%), Positives = 77/187 (41%), Gaps = 37/187 (19%)

Query: 83  GGAPNCIPCKE---------TCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCG 133
           GG    I C E          C+   C  G  C+ +     +C C   C   T   PVCG
Sbjct: 56  GGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGL-KCACQFQCH--TNYIPVCG 112

Query: 134 LDGKTYRNECALLKARCKEQPELEVQYQGRC---------------------KKTCRDVF 172
            +G TY+NEC L +A CK Q E+ V  +G C                     +K  +   
Sbjct: 113 SNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGP 172

Query: 173 CPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIG 232
           C   + C  D   N  CV CN  C     S   +C +DG +Y++ C +R+A+C+    I 
Sbjct: 173 CKYKAECDED-AENVGCV-CNIDC--SGYSFNPVCASDGSSYNNPCFVREASCIKQEQID 228

Query: 233 LAYEGKC 239
           + + G C
Sbjct: 229 IRHLGHC 235



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 35/126 (27%), Positives = 58/126 (46%), Gaps = 15/126 (11%)

Query: 206 LCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCE----DIQCTGGKKCLWDFK 261
           +CG++G TY + C LR+A C   + I +   G C           + + +G +      K
Sbjct: 110 VCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSK 169

Query: 262 VGRGRCSL-CDE-------LCP---DSKSDEPVCASDNATYASECAMKEAACSSGVLLEV 310
            G  +    CDE       +C       S  PVCASD ++Y + C ++EA+C     +++
Sbjct: 170 CGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDI 229

Query: 311 KHSGSC 316
           +H G C
Sbjct: 230 RHLGHC 235



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 5/71 (7%)

Query: 100 CGPGK---KCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPEL 156
           CGP K   +C  + +N   CVC  DCS  ++  PVC  DG +Y N C + +A C +Q ++
Sbjct: 170 CGPCKYKAECDEDAENVG-CVCNIDCSGYSFN-PVCASDGSSYNNPCFVREASCIKQEQI 227

Query: 157 EVQYQGRCKKT 167
           ++++ G C  T
Sbjct: 228 DIRHLGHCTDT 238



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 23/72 (31%), Positives = 31/72 (43%), Gaps = 5/72 (6%)

Query: 245 CEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSS 304
           C++  C  G  C  D   G G    C   C  +    PVC S+  TY +EC ++ AAC  
Sbjct: 77  CDESSCKYGGVCKED---GDGLKCACQFQCHTNYI--PVCGSNGDTYQNECFLRRAACKH 131

Query: 305 GVLLEVKHSGSC 316
              + V   G C
Sbjct: 132 QKEITVIARGPC 143


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 64/240 (26%), Positives = 86/240 (35%), Gaps = 65/240 (27%)

Query: 91   CKETCENVDCGPGKKCRMNKKNKPRCVCAPD----------CSNITWKGPVCGLDGKTYR 140
            CK TCEN     G +C +N+K   RC C P           CSN    G  C +     R
Sbjct: 4217 CKLTCEN-----GGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTC-VPSVLGR 4270

Query: 141  NECALLKARCKEQPELEVQYQG-RCKKTCRDVFCPGSSTCVVDQTNNAYC---------- 189
              C+             + + G  C KT  + FC    TC+V   N  YC          
Sbjct: 4271 PTCSCA-----------LGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDR 4319

Query: 190  ---VTCNRICPEPASSEQYLCGNDGVTYSSACHLR--KATCLLGRSIGLAYEGKCIKAKS 244
                 C+  C    +SE    G+DG +    C  R     C + + +   + G CI  K 
Sbjct: 4320 CQYYVCHHYC---VNSESCTIGDDG-SVECVCPTRYEGPKCEVDKCV-RCHGGHCIINKD 4374

Query: 245  CEDI--QCTGGKKCLWDFKVGRGRCSLCDELC-------PDSKSDEPVCASDNATYASEC 295
             EDI   CT GK            C LCD  C        D +++ PVC        ++C
Sbjct: 4375 SEDIFCNCTNGKIA--------SSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQC 4426



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 61/235 (25%), Positives = 87/235 (37%), Gaps = 46/235 (19%)

Query: 88   CIPCKETCE-NVDCGPGKKCRMNKKNKPRC-----VCAPD---CSNITWKGPVCGLDGKT 138
            CIP K  C+ + DC  G+  +  +   P C     +CA D    +++   G     DG  
Sbjct: 3565 CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSD 3624

Query: 139  YRNECALLKARCKEQPELEVQYQGRCKKTCRDV----FCPGSSTCVVDQTNNAYCVTCNR 194
               +C      CKE        Q RCK     +     C G   CV D ++   C     
Sbjct: 3625 -EMDCV---TECKED-------QFRCKNKAHCIPIRWLCDGIHDCV-DGSDEENCERGGN 3672

Query: 195  ICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYE---GKCIK--AKSCEDIQ 249
            IC     ++++LC N      S C L    C      G   +     C+K    S    +
Sbjct: 3673 IC----RADEFLCNN------SLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHR 3722

Query: 250  CTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSS 304
            C   + CL   ++    C+  DE C D+ SDE  C       A  C   E ACS+
Sbjct: 3723 CRNNRICLQSEQM----CNGIDE-CGDN-SDEDHCGGKLTYKARPCKKDEFACSN 3771



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 50/231 (21%), Positives = 76/231 (32%), Gaps = 46/231 (19%)

Query: 87   NCIPCKETCENV-DCGPG---KKCRMNKKNKPRCVCAP-DC--SNITWKGPVCGLDGKTY 139
            NCIP    C++  DC      + C+         +CA  DC  S     G     DG   
Sbjct: 3487 NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDE 3546

Query: 140  RN---ECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRIC 196
            RN    C+  + RC     +  +++           C G   C   +   + C   +  C
Sbjct: 3547 RNCETSCSKDQFRCSNGQCIPAKWK-----------CDGHEDCKYGEDEKS-CEPASPTC 3594

Query: 197  PEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKC 256
                SS +Y+C +DG   +S     +  C  G       E  C+     +  +C     C
Sbjct: 3595 ----SSREYICASDGCISASLKCNGEYDCADGSD-----EMDCVTECKEDQFRCKNKAHC 3645

Query: 257  L---WDFKVGRGRCSLCDEL--CPDSKSDEPVCASDNATYASECAMKEAAC 302
            +   W          LCD +  C D   +E      N   A E     + C
Sbjct: 3646 IPIRW----------LCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLC 3686



 Score = 30.0 bits (66), Expect = 2.8
 Identities = 29/93 (31%), Positives = 39/93 (41%), Gaps = 26/93 (27%)

Query: 87  NCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALL 146
           +C      C+ ++C    KC M  +N  RC C  D   IT        DG++        
Sbjct: 112 HCQELLSNCQQLNCQ--YKCTM-VRNSTRCYCE-DGFEITE-------DGRS-------- 152

Query: 147 KARCKEQPELEVQYQGRCKKTCRDVFCPGSSTC 179
              CK+Q E  V   G C +TCR+    GS TC
Sbjct: 153 ---CKDQDECAVY--GTCSQTCRNTH--GSYTC 178


>gi|190194423 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 9/87 (10%)

Query: 93  ETCENVDCGPGKKCRMNKKNKPRCVCAP--DCSNITWKGPVCGLDGKTYRNECALLKARC 150
           ++C +  C  G  C+ +++ KP CVC     C        VCG D +TY + C L   +C
Sbjct: 431 DSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKC 490

Query: 151 -----KEQPELEVQYQGRCKK--TCRD 170
                K+  +L++ Y G CK   TC D
Sbjct: 491 RLEGTKKGHQLQLDYFGACKSIPTCTD 517



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 28/104 (26%), Positives = 41/104 (39%), Gaps = 5/104 (4%)

Query: 151 KEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGND 210
           +E+   E   +     +C    C     C  DQ    +CV  + +   P      +CG D
Sbjct: 416 EEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTD 475

Query: 211 GVTYSSACHLRKATCLL-----GRSIGLAYEGKCIKAKSCEDIQ 249
             TY+S+CHL    C L     G  + L Y G C    +C D +
Sbjct: 476 NQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFE 519



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 7/79 (8%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDEL-CPDSKSDEPVCASDNATYASECAMKEAAC 302
           SC   QC  G  C  D + G+  C   D + CP +K  + VC +DN TYAS C +    C
Sbjct: 432 SCMSFQCKRGHICKAD-QQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKC 490

Query: 303 -----SSGVLLEVKHSGSC 316
                  G  L++ + G+C
Sbjct: 491 RLEGTKKGHQLQLDYFGAC 509


>gi|190341024 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 9/87 (10%)

Query: 93  ETCENVDCGPGKKCRMNKKNKPRCVCAP--DCSNITWKGPVCGLDGKTYRNECALLKARC 150
           ++C +  C  G  C+ +++ KP CVC     C        VCG D +TY + C L   +C
Sbjct: 431 DSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKC 490

Query: 151 -----KEQPELEVQYQGRCKK--TCRD 170
                K+  +L++ Y G CK   TC D
Sbjct: 491 RLEGTKKGHQLQLDYFGACKSIPTCTD 517



 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 28/104 (26%), Positives = 41/104 (39%), Gaps = 5/104 (4%)

Query: 151 KEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGND 210
           +E+   E   +     +C    C     C  DQ    +CV  + +   P      +CG D
Sbjct: 416 EEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTD 475

Query: 211 GVTYSSACHLRKATCLL-----GRSIGLAYEGKCIKAKSCEDIQ 249
             TY+S+CHL    C L     G  + L Y G C    +C D +
Sbjct: 476 NQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFE 519



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 7/79 (8%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDEL-CPDSKSDEPVCASDNATYASECAMKEAAC 302
           SC   QC  G  C  D + G+  C   D + CP +K  + VC +DN TYAS C +    C
Sbjct: 432 SCMSFQCKRGHICKAD-QQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKC 490

Query: 303 -----SSGVLLEVKHSGSC 316
                  G  L++ + G+C
Sbjct: 491 RLEGTKKGHQLQLDYFGAC 509


>gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]
          Length = 303

 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 6/101 (5%)

Query: 157 EVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI-CPEPASSEQYLCGNDGVTYS 215
           E + +   +  C++  C     C +D+ N   CV  +   CP P    + +C ND  T+ 
Sbjct: 61  ETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFD 120

Query: 216 SACHLRKATCLL-----GRSIGLAYEGKCIKAKSCEDIQCT 251
           S+CH     C L     G  + L Y G C     C D + T
Sbjct: 121 SSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELT 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 8/85 (9%)

Query: 89  IPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKG---PVCGLDGKTYRNECAL 145
           +  +  C+N  C  GK C +++ N P CVC    S     G    VC  D KT+ + C  
Sbjct: 66  VVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHF 125

Query: 146 LKARC-----KEQPELEVQYQGRCK 165
              +C     K+  +L + Y G CK
Sbjct: 126 FATKCTLEGTKKGHKLHLDYIGPCK 150



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 24/93 (25%), Positives = 36/93 (38%), Gaps = 18/93 (19%)

Query: 236 EGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSD-------EPVCASDN 288
           E + +    C++  C  GK C  D         +C  +C D  S        E VC++DN
Sbjct: 63  EEEVVAENPCQNHHCKHGKVCELD----ENNTPMC--VCQDPTSCPAPIGEFEKVCSNDN 116

Query: 289 ATYASECAMKEAACS-----SGVLLEVKHSGSC 316
            T+ S C      C+      G  L + + G C
Sbjct: 117 KTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPC 149


>gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]
          Length = 457

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 34/127 (26%), Positives = 51/127 (40%), Gaps = 16/127 (12%)

Query: 118 CAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSS 177
           C+ DC+    K P+C  DG+T+ + C   +A+CK+ P+LE+ Y+G CK   R   C    
Sbjct: 40  CSLDCAGSPQK-PLCASDGRTFLSRCEFQRAKCKD-PQLEIAYRGNCKDVSR---CVAER 94

Query: 178 TCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEG 237
               +Q    +        PE        C +DG      CH     C      G    G
Sbjct: 95  KYTQEQARKEFQQV---FIPE--------CNDDGTYSQVQCHSYTGYCWCVTPNGRPISG 143

Query: 238 KCIKAKS 244
             +  K+
Sbjct: 144 TAVAHKT 150



 Score = 33.5 bits (75), Expect = 0.25
 Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 1/36 (2%)

Query: 281 EPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           +P+CASD  T+ S C  + A C     LE+ + G+C
Sbjct: 50  KPLCASDGRTFLSRCEFQRAKCKD-PQLEIAYRGNC 84


>gi|54792136 follistatin-like 4 [Homo sapiens]
          Length = 842

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 27/73 (36%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACS 303
           SC    C+ G +C+   K G   C  C E C  S    PVC SD   Y + C +  AAC 
Sbjct: 64  SCGKKFCSRGSRCVLSRKTGEPECQ-CLEACRPSYV--PVCGSDGRFYENHCKLHRAACL 120

Query: 304 SGVLLEVKHSGSC 316
            G  + V HS  C
Sbjct: 121 LGKRITVIHSKDC 133



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 4/80 (5%)

Query: 167 TCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCL 226
           +C   FC   S CV+ +        C   C     S   +CG+DG  Y + C L +A CL
Sbjct: 64  SCGKKFCSRGSRCVLSRKTGEPECQCLEAC---RPSYVPVCGSDGRFYENHCKLHRAACL 120

Query: 227 LGRSIGLAYEGKC-IKAKSC 245
           LG+ I + +   C +K  +C
Sbjct: 121 LGKRITVIHSKDCFLKGDTC 140



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 94  TCENVDCGPGKKCRMNKKN-KPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKE 152
           +C    C  G +C +++K  +P C C   C       PVCG DG+ Y N C L +A C  
Sbjct: 64  SCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYV--PVCGSDGRFYENHCKLHRAACLL 121

Query: 153 QPELEVQYQGRC 164
              + V +   C
Sbjct: 122 GKRITVIHSKDC 133


>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
          Length = 837

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 3/73 (4%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACS 303
           SCE+  C  G+ C+   + G+  C+ C +LC   +  +PVC SD   Y + C +  AAC 
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECA-CMDLC--KRHYKPVCGSDGEFYENHCEVHRAACL 119

Query: 304 SGVLLEVKHSGSC 316
               + + H+  C
Sbjct: 120 KKQKITIVHNEDC 132



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 94  TCENVDCGPGKKCRMNKKN-KPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKE 152
           +CEN  CG G+ C  +++  +  C C   C       PVCG DG+ Y N C + +A C +
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECACMDLCKR--HYKPVCGSDGEFYENHCEVHRAACLK 120

Query: 153 QPELEVQYQGRC 164
           + ++ + +   C
Sbjct: 121 KQKITIVHNEDC 132



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 6/97 (6%)

Query: 167 TCRDVFCPGSSTCVVD-QTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATC 225
           +C + +C     CV   +T  A C  C  +C         +CG+DG  Y + C + +A C
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECA-CMDLCKRHYKP---VCGSDGEFYENHCEVHRAAC 118

Query: 226 LLGRSIGLAYEGKC-IKAKSCEDIQCTGGKKCLWDFK 261
           L  + I + +   C  K   C+  + +  K  L D +
Sbjct: 119 LKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQ 155


>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
          Length = 846

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 3/73 (4%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACS 303
           SCE+  C  G+ C+   + G+  C+ C +LC   +  +PVC SD   Y + C +  AAC 
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECA-CMDLC--KRHYKPVCGSDGEFYENHCEVHRAACL 119

Query: 304 SGVLLEVKHSGSC 316
               + + H+  C
Sbjct: 120 KKQKITIVHNEDC 132



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 94  TCENVDCGPGKKCRMNKKN-KPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKE 152
           +CEN  CG G+ C  +++  +  C C   C       PVCG DG+ Y N C + +A C +
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECACMDLCKR--HYKPVCGSDGEFYENHCEVHRAACLK 120

Query: 153 QPELEVQYQGRC 164
           + ++ + +   C
Sbjct: 121 KQKITIVHNEDC 132



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 6/97 (6%)

Query: 167 TCRDVFCPGSSTCVVD-QTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATC 225
           +C + +C     CV   +T  A C  C  +C         +CG+DG  Y + C + +A C
Sbjct: 63  SCENKYCGLGRHCVTSRETGQAECA-CMDLCKRHYKP---VCGSDGEFYENHCEVHRAAC 118

Query: 226 LLGRSIGLAYEGKC-IKAKSCEDIQCTGGKKCLWDFK 261
           L  + I + +   C  K   C+  + +  K  L D +
Sbjct: 119 LKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQ 155


>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
          Length = 847

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 3/73 (4%)

Query: 244 SCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACS 303
           SCE+  C  G+ C+   + G+  C+ C +LC   +  +PVC SD   Y + C +  AAC 
Sbjct: 64  SCENKYCGLGRHCVTSRETGQAECA-CMDLC--KRHYKPVCGSDGEFYENHCEVHRAACL 120

Query: 304 SGVLLEVKHSGSC 316
               + + H+  C
Sbjct: 121 KKQKITIVHNEDC 133



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 94  TCENVDCGPGKKCRMNKKN-KPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKE 152
           +CEN  CG G+ C  +++  +  C C   C       PVCG DG+ Y N C + +A C +
Sbjct: 64  SCENKYCGLGRHCVTSRETGQAECACMDLCKR--HYKPVCGSDGEFYENHCEVHRAACLK 121

Query: 153 QPELEVQYQGRC 164
           + ++ + +   C
Sbjct: 122 KQKITIVHNEDC 133



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 6/97 (6%)

Query: 167 TCRDVFCPGSSTCVVD-QTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATC 225
           +C + +C     CV   +T  A C  C  +C         +CG+DG  Y + C + +A C
Sbjct: 64  SCENKYCGLGRHCVTSRETGQAECA-CMDLCKRHYKP---VCGSDGEFYENHCEVHRAAC 119

Query: 226 LLGRSIGLAYEGKC-IKAKSCEDIQCTGGKKCLWDFK 261
           L  + I + +   C  K   C+  + +  K  L D +
Sbjct: 120 LKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQ 156


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 58/242 (23%), Positives = 82/242 (33%), Gaps = 36/242 (14%)

Query: 86  PNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECAL 145
           PNC      C    C  G  CR        C C P  +    +  +    G   +N  A 
Sbjct: 213 PNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGAC 272

Query: 146 LKA----RCKEQPELEVQYQGRCKKTCRDV--FCPGSSTCVVDQTNNAY-CVTCNRICPE 198
           +       C+  PE   QY       C+ +   C    TC    T+  Y CV  N    E
Sbjct: 273 VDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTC--HNTHGGYNCVCVNGWTGE 330

Query: 199 PASSEQYLCGNDGVTYSSACHLRKAT----CLLGRSIGLAYEGKCIKAKSCEDIQCTGGK 254
             S     C +    + + CH R A+    C  GR+ GL     C    +C    C  G 
Sbjct: 331 DCSENIDDCASAACFHGATCHDRVASFYCECPHGRT-GLL----CHLNDACISNPCNEGS 385

Query: 255 KCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSG 314
            C  +   G+  C+     CP   +  P C+ D      EC++    C        +H+G
Sbjct: 386 NCDTNPVNGKAICT-----CPSGYTG-PACSQD----VDECSLGANPC--------EHAG 427

Query: 315 SC 316
            C
Sbjct: 428 KC 429



 Score = 29.3 bits (64), Expect = 4.8
 Identities = 23/69 (33%), Positives = 27/69 (39%), Gaps = 8/69 (11%)

Query: 163  RCKKT---CRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACH 219
            RC+     C+   C    TC V  +N A       IC  PA  E   C ND  T  S   
Sbjct: 1303 RCESVINGCKGKPCKNGGTCAV-ASNTAR----GFICKCPAGFEGATCENDARTCGSLRC 1357

Query: 220  LRKATCLLG 228
            L   TC+ G
Sbjct: 1358 LNGGTCISG 1366


>gi|28212222 WFIKKN2 protein [Homo sapiens]
          Length = 576

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 42/164 (25%), Positives = 65/164 (39%), Gaps = 34/164 (20%)

Query: 154 PELEVQYQGRCKKTCR-DVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGV 212
           P +   + G C      +++    STC  +   +  C T  + CP        +CG    
Sbjct: 36  PPIRYSHAGICPNDMNPNLWVDAQSTCRRECETDQECETYEKCCPN-------VCG---- 84

Query: 213 TYSSACHLRKATCLLGRS--IGLAYEGKCIKAKSCEDIQCTG-GKKC-LWDFKVGRGRCS 268
             + +C   +   + G+   +G+  E       +C+   C   G +C +WD   G+  C 
Sbjct: 85  --TKSCVAARYMDVKGKKGPVGMPKEA------TCDHFMCLQQGSECDIWD---GQPVCK 133

Query: 269 LCDELCPDSKSDEP--VCASDNATYASECAMKEAACSSGVLLEV 310
                C D    EP   CASD  TY + C M   ACS G+ L V
Sbjct: 134 -----CKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAV 172


>gi|78190498 secreted modular calcium-binding protein 1 isoform 1
           [Homo sapiens]
          Length = 435

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 35/132 (26%), Positives = 51/132 (38%), Gaps = 24/132 (18%)

Query: 118 CAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSS 177
           C   CS  T   P+C  DG++Y + C   +A+C++ P L V ++GRCK         G S
Sbjct: 43  CNLHCSR-TQPKPICASDGRSYESMCEYQRAKCRD-PTLGVVHRGRCKDA-------GQS 93

Query: 178 TCVVDQTNNAYCVTCNRICPEPASSEQYL-----CGNDGVTYSSACHLRKATCLLGRSIG 232
            C +++              E A   Q       CG DG      CH     C      G
Sbjct: 94  KCRLERAQ----------ALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDG 143

Query: 233 LAYEGKCIKAKS 244
               G  ++ K+
Sbjct: 144 KPISGSSVQNKT 155



 Score = 32.3 bits (72), Expect = 0.57
 Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)

Query: 281 EPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           +P+CASD  +Y S C  + A C     L V H G C
Sbjct: 53  KPICASDGRSYESMCEYQRAKCRDPT-LGVVHRGRC 87


>gi|11545873 secreted modular calcium-binding protein 1 isoform 2
           [Homo sapiens]
          Length = 434

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 35/132 (26%), Positives = 51/132 (38%), Gaps = 24/132 (18%)

Query: 118 CAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSS 177
           C   CS  T   P+C  DG++Y + C   +A+C++ P L V ++GRCK         G S
Sbjct: 43  CNLHCSR-TQPKPICASDGRSYESMCEYQRAKCRD-PTLGVVHRGRCKDA-------GQS 93

Query: 178 TCVVDQTNNAYCVTCNRICPEPASSEQYL-----CGNDGVTYSSACHLRKATCLLGRSIG 232
            C +++              E A   Q       CG DG      CH     C      G
Sbjct: 94  KCRLERAQ----------ALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDG 143

Query: 233 LAYEGKCIKAKS 244
               G  ++ K+
Sbjct: 144 KPISGSSVQNKT 155



 Score = 32.3 bits (72), Expect = 0.57
 Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)

Query: 281 EPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           +P+CASD  +Y S C  + A C     L V H G C
Sbjct: 53  KPICASDGRSYESMCEYQRAKCRDPT-LGVVHRGRC 87


>gi|154759249 keratin associated protein 10-11 [Homo sapiens]
          Length = 298

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 46/205 (22%), Positives = 71/205 (34%), Gaps = 28/205 (13%)

Query: 88  CIP-------CKETC-ENVDCGPGKKCRMNKKNKPRCV----CAPDCSNITWKGPVCGLD 135
           C+P       CK  C   V CG    C      +P C     C P C       PVC + 
Sbjct: 100 CVPVCCKTVCCKPVCCVPVCCGAASSCCRQSSCQPACCASSSCQPACCVPVCCKPVCCVS 159

Query: 136 GKTYRNECALLKARCKEQPELEVQYQGRC--KKTCRDVFC-PGSSTCVVDQTNNAYC--- 189
             +  +     ++ C+        YQ  C     C+ V+C P     V  + +++ C   
Sbjct: 160 TCSEDSSSCCQQSSCQPACCTSSSYQQACCVPVCCKTVYCKPICCVPVCSRASSSRCQQP 219

Query: 190 ----VTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSC 245
                 C   C  P+SS   LC        S C +  ++C    S   + +  C +  SC
Sbjct: 220 SCQPACCTTSCCRPSSSVSLLC---HPVCRSTCCVPVSSCCAPTS---SCQSSCCRPASC 273

Query: 246 EDIQCTGGKKCLWDFKVGRGRCSLC 270
             + C      L  + +  G+ S C
Sbjct: 274 VSLLCRPASSRLACYSLCSGKKSSC 298



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 50/232 (21%), Positives = 70/232 (30%), Gaps = 42/232 (18%)

Query: 91  CKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALL--KA 148
           C+  CE   C  G  C  +        C P C   +   P C       +  C  +  K 
Sbjct: 58  CQAACEPSACQSG--CTSS--------CTPSCCQQSSCQPACCTSSPCQQACCVPVCCKT 107

Query: 149 RCKEQPELEVQYQGRCKKTCRDVFCPG--SSTCVVDQTNNAYCVT--CNRICPEPASSEQ 204
            C             CK  C    C G  SS C       A C +  C   C  P   + 
Sbjct: 108 VC-------------CKPVCCVPVCCGAASSCCRQSSCQPACCASSSCQPACCVPVCCKP 154

Query: 205 YLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGR 264
             C +     SS+C  ++++C        +Y+  C     C+ + C          +   
Sbjct: 155 VCCVSTCSEDSSSC-CQQSSCQPACCTSSSYQQACCVPVCCKTVYCKPICCVPVCSRASS 213

Query: 265 GRCSL--CDELC-------PDSKSD---EPVCASDNATYASECAMKEAACSS 304
            RC    C   C       P S       PVC S      S C    ++C S
Sbjct: 214 SRCQQPSCQPACCTTSCCRPSSSVSLLCHPVCRSTCCVPVSSCCAPTSSCQS 265



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 42/205 (20%), Positives = 60/205 (29%), Gaps = 41/205 (20%)

Query: 114 PRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFC 173
           P   C P CS      P C                 C   P L +         C  V C
Sbjct: 23  PESCCEPPCS-----APSC-----------------CAPAPSLSL--------VCTPVSC 52

Query: 174 PGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGL 233
             S  C      +A    C   C  P+  +Q  C     T SS C  ++A C     + +
Sbjct: 53  VSSPCCQAACEPSACQSGCTSSCT-PSCCQQSSCQPACCT-SSPC--QQACC-----VPV 103

Query: 234 AYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRC--SLCDELCPDSKSDEPVCASDNATY 291
             +  C K   C  + C     C          C  S C   C      +PVC     + 
Sbjct: 104 CCKTVCCKPVCCVPVCCGAASSCCRQSSCQPACCASSSCQPACCVPVCCKPVCCVSTCSE 163

Query: 292 ASECAMKEAACSSGVLLEVKHSGSC 316
            S    ++++C         +  +C
Sbjct: 164 DSSSCCQQSSCQPACCTSSSYQQAC 188


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 50/219 (22%), Positives = 76/219 (34%), Gaps = 41/219 (18%)

Query: 86   PNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLD---------G 136
            P   P   TC N+ C  G  C +N + +P+C C P      + G  C LD         G
Sbjct: 4191 PPDAPRPGTC-NLQCFNGGSCFLNARRQPKCRCQP-----RYTGDKCELDQCWEHCRNGG 4244

Query: 137  KTYRNECALLKARCKEQPELEVQYQG-RCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI 195
                +   +   RC         + G +C +     +C  +STC V+Q N   C      
Sbjct: 4245 TCAASPSGMPTCRC------PTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGF 4298

Query: 196  CPEPASSEQY--LCGNDGVTYSSACHLRKATCLL--------GRSIGLAYEGKCIKAKSC 245
              +     Q    C N G    +A   R+  C                  EG C+  K  
Sbjct: 4299 LGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQS 4358

Query: 246  EDI--QCTGGK------KCLWDFKVGRGRCSLCDELCPD 276
             D+   CT G+       C+     G G C++  ++ P+
Sbjct: 4359 GDVTCNCTDGRVAPSCLTCVGHCSNG-GSCTMNSKMMPE 4396



 Score = 35.4 bits (80), Expect = 0.067
 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 10/48 (20%)

Query: 85   APNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVC 132
            AP+C+ C   C N     G  C MN K  P C C P  +     GP C
Sbjct: 4371 APSCLTCVGHCSN-----GGSCTMNSKMMPECQCPPHMT-----GPRC 4408


>gi|93141003 testican 3 isoform 1 [Homo sapiens]
          Length = 433

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)

Query: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202
           K  C  + C     C+   +  A C++  R+                     C + P   
Sbjct: 84  KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 143

Query: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
              +CG+DG TYS  C L    C+LG+ I +  EG C
Sbjct: 144 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)

Query: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           C  C  + P      PVC SD  TY+ +C ++  AC  G  + VK  G C
Sbjct: 136 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180



 Score = 35.0 bits (79), Expect = 0.088
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
           + +  PVCG DG TY  +C L    C    ++ V+ +G C
Sbjct: 141 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180


>gi|93141001 testican 3 isoform 2 [Homo sapiens]
          Length = 436

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)

Query: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202
           K  C  + C     C+   +  A C++  R+                     C + P   
Sbjct: 87  KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 146

Query: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
              +CG+DG TYS  C L    C+LG+ I +  EG C
Sbjct: 147 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)

Query: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           C  C  + P      PVC SD  TY+ +C ++  AC  G  + VK  G C
Sbjct: 139 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183



 Score = 35.0 bits (79), Expect = 0.088
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
           + +  PVCG DG TY  +C L    C    ++ V+ +G C
Sbjct: 144 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183


>gi|7657453 serine peptidase inhibitor, Kazal type 4 [Homo sapiens]
          Length = 86

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 2/46 (4%)

Query: 119 APDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
           +P CS ++    VCG DG TY NEC L  AR K + ++++   G+C
Sbjct: 43  SPTCSQMS--NLVCGTDGLTYTNECQLCLARIKTKQDIQIMKDGKC 86



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 192 CNRICPEPASSEQ--YLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
           C  +   P  S+    +CG DG+TY++ C L  A     + I +  +GKC
Sbjct: 37  CEHMVESPTCSQMSNLVCGTDGLTYTNECQLCLARIKTKQDIQIMKDGKC 86


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 60/238 (25%), Positives = 80/238 (33%), Gaps = 43/238 (18%)

Query: 93  ETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKA--RC 150
           E  E  DCGP + CR    N   C  A        +G  C     T   EC +  A   C
Sbjct: 417 ERGEQCDCGPPEDCRNRCCNSTTCQLA--------EGAQCA--HGTCCQECKVKPAGELC 466

Query: 151 ---KEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLC 207
              K+  +LE    GR  +   D F    + C     +  YC   N  CP  A   Q   
Sbjct: 467 RPKKDMCDLEEFCDGRHPECPEDAFQENGTPC-----SGGYCY--NGACPTLAQQCQAFW 519

Query: 208 GNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRC 267
           G  G     +C            I    +    +A  C  +QC GG++ L     GR  C
Sbjct: 520 GPGGQAAEESC--------FSYDILPGCKASRYRADMCGVLQCKGGQQPL-----GRAIC 566

Query: 268 --SLCDEL-CPDSKSDEPV-----CASDNATYASECAMKEAACSSGVLLEVKHSGSCN 317
              +C  L   D  + EPV     C  +   +   C       SS    +  + G CN
Sbjct: 567 IVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCN 624


>gi|7662036 sparc/osteonectin, cwcv and kazal-like domains
           proteoglycan (testican) 2 isoform 2 [Homo sapiens]
          Length = 424

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 26/95 (27%), Positives = 38/95 (40%), Gaps = 21/95 (22%)

Query: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNR------------------ICPEPASSEQY- 205
           K  C+ V C     C+      A C++  +                  IC +P    Q  
Sbjct: 87  KDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIKQPTVKLHGNKDSIC-KPCHMAQLA 145

Query: 206 -LCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
            +CG+DG TYSS C L +  CL  + + +  EG C
Sbjct: 146 SVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC 180



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 27/120 (22%), Positives = 42/120 (35%), Gaps = 25/120 (20%)

Query: 68  EDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCV---------- 117
           ++V D+ +  W     G       K+ C+ V C   K C      +  C+          
Sbjct: 63  DEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIK 122

Query: 118 -------------CAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
                        C P   ++     VCG DG TY + C L +  C    +L V+ +G C
Sbjct: 123 QPTVKLHGNKDSICKP--CHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC 180



 Score = 35.0 bits (79), Expect = 0.088
 Identities = 15/34 (44%), Positives = 20/34 (58%)

Query: 283 VCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
           VC SD  TY+S C +++ AC S   L V+  G C
Sbjct: 147 VCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPC 180


>gi|189163504 serine peptidase inhibitor, Kazal type 5 isoform c
           precursor [Homo sapiens]
          Length = 916

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 44/169 (26%), Positives = 68/169 (40%), Gaps = 28/169 (16%)

Query: 131 VCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTC--RDVFCPGSSTCVVDQTNNAY 188
           VCG DGKTY N CAL     K   ++ V+ +G CK +   +DV C      V D      
Sbjct: 118 VCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDV-CSAFRPFVRDGR---- 172

Query: 189 CVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDI 248
            + C R           + G DG T+ + C +  A   L  +     EG+    ++ E  
Sbjct: 173 -LGCTR-------ENDPVLGPDGKTHGNKCAM-CAELFLKEAENAKREGETRIRRNAEKD 223

Query: 249 QCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAM 297
            C   +K     + GR  C         ++  +PV   D   + ++CA+
Sbjct: 224 FCKEYEK---QVRNGRLFC---------TRESDPVRGPDGRMHGNKCAL 260



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 25/127 (19%)

Query: 196 CPEPASSEQYLCGNDGVTYSSACHLRKATCLL-----GRSIGLA-YEGKCIKAKSCEDIQ 249
           CP+     Q L   DG+ + + C    ATC +      +S   A +  +  KA +  ++ 
Sbjct: 44  CPQDKKFFQSL---DGIMFINKC----ATCKMILEKEAKSQKRARHLARAPKATAPTELN 96

Query: 250 CTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLE 309
           C        DFK G       D +CPD    E VC +D  TY + CA+      +G  + 
Sbjct: 97  CD-------DFKKGERDG---DFICPDYY--EAVCGTDGKTYDNRCALCAENAKTGSQIG 144

Query: 310 VKHSGSC 316
           VK  G C
Sbjct: 145 VKSEGEC 151



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 40/162 (24%), Positives = 63/162 (38%), Gaps = 24/162 (14%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPELEVQY-QGRCKKTCRDVFCPGSSTC--VVDQTNN 186
           PV   DGK+Y N+C + KA+ + + E + +Y + R   T  +    G  TC     Q  N
Sbjct: 727 PVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSE---SGKDTCDEFRSQMKN 783

Query: 187 AYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCE 246
              + C R           + G DG T+ + C + K          L  E    K K  E
Sbjct: 784 GKLI-CTR-------ESDPVRGPDGKTHGNKCTMCKEK--------LEREAAEKKKKEDE 827

Query: 247 DIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDN 288
           D   TG +    +      +  LC E     ++ + +C  +N
Sbjct: 828 DRSNTGERSNTGE--RSNDKEDLCREFRSMQRNGKLICTREN 867



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 13/26 (50%), Positives = 19/26 (73%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPE 155
           PV G DGKT+ N+CA+ KA  +++ E
Sbjct: 652 PVRGPDGKTHGNKCAMCKAVFQKENE 677



 Score = 28.9 bits (63), Expect = 6.3
 Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 1/45 (2%)

Query: 130 PVCGLDGKTYRNECAL-LKARCKEQPELEVQYQGRCKKTCRDVFC 173
           PV G DGKT+ N+CA+  +   KE    + + + R ++     FC
Sbjct: 181 PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFC 225


>gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b
           precursor [Homo sapiens]
          Length = 1064

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 44/169 (26%), Positives = 68/169 (40%), Gaps = 28/169 (16%)

Query: 131 VCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTC--RDVFCPGSSTCVVDQTNNAY 188
           VCG DGKTY N CAL     K   ++ V+ +G CK +   +DV C      V D      
Sbjct: 118 VCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDV-CSAFRPFVRDGR---- 172

Query: 189 CVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDI 248
            + C R           + G DG T+ + C +  A   L  +     EG+    ++ E  
Sbjct: 173 -LGCTR-------ENDPVLGPDGKTHGNKCAM-CAELFLKEAENAKREGETRIRRNAEKD 223

Query: 249 QCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAM 297
            C   +K     + GR  C         ++  +PV   D   + ++CA+
Sbjct: 224 FCKEYEK---QVRNGRLFC---------TRESDPVRGPDGRMHGNKCAL 260



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 7/114 (6%)

Query: 130  PVCGLDGKTYRNECALLKA--RCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNA 187
            PV G DGK Y N+C + +A    +     ++Q +    +  ++   P S + +  +    
Sbjct: 936  PVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKD 995

Query: 188  YCVT--CNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
            Y V      +CP+       +CG+DG TY++ C L     +   +  +   GKC
Sbjct: 996  YRVLPRIGYLCPKDLKP---VCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1046



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 25/127 (19%)

Query: 196 CPEPASSEQYLCGNDGVTYSSACHLRKATCLL-----GRSIGLA-YEGKCIKAKSCEDIQ 249
           CP+     Q L   DG+ + + C    ATC +      +S   A +  +  KA +  ++ 
Sbjct: 44  CPQDKKFFQSL---DGIMFINKC----ATCKMILEKEAKSQKRARHLARAPKATAPTELN 96

Query: 250 CTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLE 309
           C        DFK G       D +CPD    E VC +D  TY + CA+      +G  + 
Sbjct: 97  CD-------DFKKGERDG---DFICPDYY--EAVCGTDGKTYDNRCALCAENAKTGSQIG 144

Query: 310 VKHSGSC 316
           VK  G C
Sbjct: 145 VKSEGEC 151



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 14/38 (36%), Positives = 21/38 (55%)

Query: 130  PVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKT 167
            PVCG DG+TY N C L       Q    ++  G+C+++
Sbjct: 1012 PVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEES 1049



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 40/162 (24%), Positives = 63/162 (38%), Gaps = 24/162 (14%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPELEVQY-QGRCKKTCRDVFCPGSSTC--VVDQTNN 186
           PV   DGK+Y N+C + KA+ + + E + +Y + R   T  +    G  TC     Q  N
Sbjct: 727 PVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSE---SGKDTCDEFRSQMKN 783

Query: 187 AYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCE 246
              + C R           + G DG T+ + C + K          L  E    K K  E
Sbjct: 784 GKLI-CTR-------ESDPVRGPDGKTHGNKCTMCKEK--------LEREAAEKKKKEDE 827

Query: 247 DIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDN 288
           D   TG +    +      +  LC E     ++ + +C  +N
Sbjct: 828 DRSNTGERSNTGE--RSNDKEDLCREFRSMQRNGKLICTREN 867



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 13/26 (50%), Positives = 19/26 (73%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPE 155
           PV G DGKT+ N+CA+ KA  +++ E
Sbjct: 652 PVRGPDGKTHGNKCAMCKAVFQKENE 677



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 45/195 (23%), Positives = 72/195 (36%), Gaps = 25/195 (12%)

Query: 130  PVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNA-- 187
            PV G  GK + N+CA+    C+   + E   +   KK   +      S    D+ +    
Sbjct: 869  PVRGPYGKMHINKCAM----CQSIFDREANER---KKKDEEKSSSKPSNNAKDECSEFRN 921

Query: 188  YCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLG--RSIGLAYEGKCIKAKSC 245
            Y      ICP        + G DG  Y++ C++ +A  L        L  +   ++A   
Sbjct: 922  YIRNNELICPR---ENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQE 978

Query: 246  ED----IQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAA 301
            ED          + C  D++V          LCP  K  +PVC  D  TY + C +    
Sbjct: 979  EDSPDSFSSLDSEMCK-DYRV----LPRIGYLCP--KDLKPVCGDDGQTYNNPCMLCHEN 1031

Query: 302  CSSGVLLEVKHSGSC 316
                    ++ +G C
Sbjct: 1032 LIRQTNTHIRSTGKC 1046



 Score = 28.9 bits (63), Expect = 6.3
 Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 1/45 (2%)

Query: 130 PVCGLDGKTYRNECAL-LKARCKEQPELEVQYQGRCKKTCRDVFC 173
           PV G DGKT+ N+CA+  +   KE    + + + R ++     FC
Sbjct: 181 PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFC 225


>gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
           precursor [Homo sapiens]
          Length = 1094

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 44/169 (26%), Positives = 68/169 (40%), Gaps = 28/169 (16%)

Query: 131 VCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTC--RDVFCPGSSTCVVDQTNNAY 188
           VCG DGKTY N CAL     K   ++ V+ +G CK +   +DV C      V D      
Sbjct: 118 VCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDV-CSAFRPFVRDGR---- 172

Query: 189 CVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDI 248
            + C R           + G DG T+ + C +  A   L  +     EG+    ++ E  
Sbjct: 173 -LGCTR-------ENDPVLGPDGKTHGNKCAM-CAELFLKEAENAKREGETRIRRNAEKD 223

Query: 249 QCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAM 297
            C   +K     + GR  C         ++  +PV   D   + ++CA+
Sbjct: 224 FCKEYEK---QVRNGRLFC---------TRESDPVRGPDGRMHGNKCAL 260



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 7/114 (6%)

Query: 130  PVCGLDGKTYRNECALLKA--RCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNA 187
            PV G DGK Y N+C + +A    +     ++Q +    +  ++   P S + +  +    
Sbjct: 966  PVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKD 1025

Query: 188  YCVT--CNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
            Y V      +CP+       +CG+DG TY++ C L     +   +  +   GKC
Sbjct: 1026 YRVLPRIGYLCPKDLKP---VCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1076



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 25/127 (19%)

Query: 196 CPEPASSEQYLCGNDGVTYSSACHLRKATCLL-----GRSIGLA-YEGKCIKAKSCEDIQ 249
           CP+     Q L   DG+ + + C    ATC +      +S   A +  +  KA +  ++ 
Sbjct: 44  CPQDKKFFQSL---DGIMFINKC----ATCKMILEKEAKSQKRARHLARAPKATAPTELN 96

Query: 250 CTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLE 309
           C        DFK G       D +CPD    E VC +D  TY + CA+      +G  + 
Sbjct: 97  CD-------DFKKGERDG---DFICPDYY--EAVCGTDGKTYDNRCALCAENAKTGSQIG 144

Query: 310 VKHSGSC 316
           VK  G C
Sbjct: 145 VKSEGEC 151



 Score = 35.8 bits (81), Expect = 0.051
 Identities = 14/38 (36%), Positives = 21/38 (55%)

Query: 130  PVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKT 167
            PVCG DG+TY N C L       Q    ++  G+C+++
Sbjct: 1042 PVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEES 1079



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 40/162 (24%), Positives = 63/162 (38%), Gaps = 24/162 (14%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPELEVQY-QGRCKKTCRDVFCPGSSTC--VVDQTNN 186
           PV   DGK+Y N+C + KA+ + + E + +Y + R   T  +    G  TC     Q  N
Sbjct: 727 PVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSE---SGKDTCDEFRSQMKN 783

Query: 187 AYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCE 246
              + C R           + G DG T+ + C + K          L  E    K K  E
Sbjct: 784 GKLI-CTR-------ESDPVRGPDGKTHGNKCTMCKEK--------LEREAAEKKKKEDE 827

Query: 247 DIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDN 288
           D   TG +    +      +  LC E     ++ + +C  +N
Sbjct: 828 DRSNTGERSNTGE--RSNDKEDLCREFRSMQRNGKLICTREN 867



 Score = 33.1 bits (74), Expect = 0.33
 Identities = 48/218 (22%), Positives = 78/218 (35%), Gaps = 41/218 (18%)

Query: 130  PVCGLDGKTYRNECALLKA---------RCKEQPELEVQYQGRCKKTCRDVFC------- 173
            PV G  GK + N+CA+ ++         + K++ +   +     K  CR V         
Sbjct: 869  PVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKF 928

Query: 174  --PGSSTCVVDQTNNAYCVTCNR-------ICPEPASSEQYLCGNDGVTYSSACHLRKAT 224
              PG S   V + +   C            ICP        + G DG  Y++ C++ +A 
Sbjct: 929  RQPGRSLASVARMSTDECSEFRNYIRNNELICPR---ENDPVHGADGKFYTNKCYMCRAV 985

Query: 225  CLLG--RSIGLAYEGKCIKAKSCED----IQCTGGKKCLWDFKVGRGRCSLCDELCPDSK 278
             L        L  +   ++A   ED          + C  D++V          LCP  K
Sbjct: 986  FLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCK-DYRV----LPRIGYLCP--K 1038

Query: 279  SDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
              +PVC  D  TY + C +            ++ +G C
Sbjct: 1039 DLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1076



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 13/26 (50%), Positives = 19/26 (73%)

Query: 130 PVCGLDGKTYRNECALLKARCKEQPE 155
           PV G DGKT+ N+CA+ KA  +++ E
Sbjct: 652 PVRGPDGKTHGNKCAMCKAVFQKENE 677



 Score = 28.9 bits (63), Expect = 6.3
 Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 1/45 (2%)

Query: 130 PVCGLDGKTYRNECAL-LKARCKEQPELEVQYQGRCKKTCRDVFC 173
           PV G DGKT+ N+CA+  +   KE    + + + R ++     FC
Sbjct: 181 PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFC 225


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,222,532
Number of Sequences: 37866
Number of extensions: 808127
Number of successful extensions: 2235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 1828
Number of HSP's gapped (non-prelim): 405
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.