Search of human proteins with 54144631

Search of human proteins with 54144631

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
         (580 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]         1157   0.0  
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa...   367   e-101
gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa...   363   e-100
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa...   358   7e-99
gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s...   270   3e-72
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s...   270   3e-72
gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s...   270   3e-72
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s...   270   3e-72
gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s...   261   2e-69
gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s...   261   2e-69
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    57   5e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    54   3e-07
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    54   3e-07
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...    52   2e-06
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...    52   2e-06
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...    52   2e-06
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...    52   2e-06
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    52   2e-06
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...    52   2e-06
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    52   2e-06
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...    52   2e-06
gi|148746195 trichohyalin [Homo sapiens]                               49   2e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   4e-05
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   4e-05
gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap...    47   4e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     46   8e-05
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    45   1e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    45   1e-04
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    45   1e-04
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    45   1e-04

>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
          Length = 580

 Score = 1157 bits (2994), Expect = 0.0
 Identities = 580/580 (100%), Positives = 580/580 (100%)

Query: 1   MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPI 60
           MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPI
Sbjct: 1   MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPI 60

Query: 61  RRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIF 120
           RRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIF
Sbjct: 61  RRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIF 120

Query: 121 KPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLEN 180
           KPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLEN
Sbjct: 121 KPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLEN 180

Query: 181 GQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPL 240
           GQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPL
Sbjct: 181 GQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPL 240

Query: 241 PPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTT 300
           PPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTT
Sbjct: 241 PPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTT 300

Query: 301 GSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLP 360
           GSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLP
Sbjct: 301 GSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLP 360

Query: 361 EIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCR 420
           EIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCR
Sbjct: 361 EIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCR 420

Query: 421 KDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI 480
           KDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI
Sbjct: 421 KDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI 480

Query: 481 LKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADK 540
           LKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADK
Sbjct: 481 LKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADK 540

Query: 541 PWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           PWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
Sbjct: 541 PWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 580


>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
           sapiens]
          Length = 559

 Score =  367 bits (943), Expect = e-101
 Identities = 248/576 (43%), Positives = 331/576 (57%), Gaps = 83/576 (14%)

Query: 60  IRRVRSKSDTPYLAEARISFNLGAAE---EVERLAAMRSDSLVPGTHTPPIRRRSKFANL 116
           + R RS+SD   L ++  + +  A E   E+++    R + LV G  TPP+RR SK A L
Sbjct: 12  VSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATL 71

Query: 117 GRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEED 176
           GRIFKPWKWRKKK+EK K T++ALE+K++ RQ REELIK+G+L E+ ++D E    N + 
Sbjct: 72  GRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLL-EMMEQDAESKTCNPDG 130

Query: 177 SLENGQS----------------------LSSSQLSL----------------PALSEME 198
              + QS                        + Q+SL                P+ S  E
Sbjct: 131 GPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGE 190

Query: 199 PVP----MPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGP 254
                  +P      + L  +D +D P       +  LP   SPPL P           P
Sbjct: 191 EADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLP---SPPLLPTP---------P 238

Query: 255 DLSLVSYTAQKSGQQGV--AQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRM 312
             +    T   +GQ  +  A    +  PS ++ QL   +   HL  TT   P+ PS  R+
Sbjct: 239 PKASSKTTKNVTGQATLFQASSMKSADPS-LRGQLSTPTGSPHL--TTVHRPLPPS--RV 293

Query: 313 IDELNKTLAMTMQRLESSEQRVPCSTSY--------HSSGLHSGDGVTKAGPMGLPEIRQ 364
           I+EL++ LA T  R +S + R    +           +S +  G    +A       +  
Sbjct: 294 IEELHRALA-TKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFD-GALEN 351

Query: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
             T   E ++NKEN+   S+ +D   LY       +++E  + S+ + +L  K C+K+ L
Sbjct: 352 KRTAAKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRK-CKKELL 403

Query: 425 AIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPR 484
           A+KL NRPSK+ELE++NI PR+TDEER E+RQQI  KL++RLSQRP  EELE+RNILK R
Sbjct: 404 AVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQR 463

Query: 485 NEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTR 544
           N+Q EQEE+REIK+RLTRKL+QRPTV+ELR+RKILIRFSDYVEVA AQDYDRRADKPWTR
Sbjct: 464 NDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR 523

Query: 545 LTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           L+AADKAAIRKELNE+KS EMEVH  S+HLTRFHRP
Sbjct: 524 LSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559


>gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
           sapiens]
          Length = 448

 Score =  363 bits (933), Expect = e-100
 Identities = 233/495 (47%), Positives = 302/495 (61%), Gaps = 62/495 (12%)

Query: 94  RSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREEL 153
           R + LV G  TPP+RR SK A LGRIFKPWKWRKKK+EK K T++ALE+K++ RQ REEL
Sbjct: 8   RPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREEL 67

Query: 154 IKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQ 213
           IK+G+L E+ ++D E    N +    + QS              EP P P+     E L 
Sbjct: 68  IKKGLL-EMMEQDAESKTCNPDGGPRSVQS--------------EP-PTPKS----ETLT 107

Query: 214 PSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQ 273
             D      PG+P+      V L  PL     +          +L   ++ KS       
Sbjct: 108 SEDAQ----PGSPLATGTDQVSLDKPLSSAAHLD----DAGQATLFQASSMKSAD----- 154

Query: 274 HHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQR 333
                 PS ++ QL   +   HL  TT   P+ PS  R+I+EL++ LA T  R +S + R
Sbjct: 155 ------PS-LRGQLSTPTGSPHL--TTVHRPLPPS--RVIEELHRALA-TKHRQDSFQGR 202

Query: 334 VPCSTSY--------HSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDY 385
               +           +S +  G    +A       +    T   E ++NKEN+   S+ 
Sbjct: 203 ESKGSPKKRLDVRLSRTSSVERGKEREEAWSFD-GALENKRTAAKESEENKENLIINSEL 261

Query: 386 EDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPR 445
           +D   LY       +++E  + S+ + +L  K C+K+ LA+KL NRPSK+ELE++NI PR
Sbjct: 262 KDDLLLY-------QDEEALNDSIISGTLPRK-CKKELLAVKLRNRPSKQELEDRNIFPR 313

Query: 446 QTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLS 505
           +TDEER E+RQQI  KL++RLSQRP  EELE+RNILK RN+Q EQEE+REIK+RLTRKL+
Sbjct: 314 RTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLN 373

Query: 506 QRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEM 565
           QRPTV+ELR+RKILIRFSDYVEVA AQDYDRRADKPWTRL+AADKAAIRKELNE+KS EM
Sbjct: 374 QRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEM 433

Query: 566 EVHELSRHLTRFHRP 580
           EVH  S+HLTRFHRP
Sbjct: 434 EVHASSKHLTRFHRP 448


>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
           sapiens]
          Length = 518

 Score =  358 bits (919), Expect = 7e-99
 Identities = 239/539 (44%), Positives = 313/539 (58%), Gaps = 80/539 (14%)

Query: 94  RSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREEL 153
           R + LV G  TPP+RR SK A LGRIFKPWKWRKKK+EK K T++ALE+K++ RQ REEL
Sbjct: 8   RPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREEL 67

Query: 154 IKRGVLKEIYDKDGELSISNEEDSLENGQS----------------------LSSSQLSL 191
           IK+G+L E+ ++D E    N +    + QS                        + Q+SL
Sbjct: 68  IKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSL 126

Query: 192 ----------------PALSEMEPVP----MPRDPCSYEVLQPSDIMDGPDPGAPVKLPC 231
                           P+ S  E       +P      + L  +D +D P       +  
Sbjct: 127 DKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQ 186

Query: 232 LPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGV--AQHHHTVLPSQIQHQLQY 289
           LP   SPPL P           P  +    T   +GQ  +  A    +  PS ++ QL  
Sbjct: 187 LP---SPPLLPTP---------PPKASSKTTKNVTGQATLFQASSMKSADPS-LRGQLST 233

Query: 290 GSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSY--------H 341
            +   HL  TT   P+ PS  R+I+EL++ LA T  R +S + R    +           
Sbjct: 234 PTGSPHL--TTVHRPLPPS--RVIEELHRALA-TKHRQDSFQGRESKGSPKKRLDVRLSR 288

Query: 342 SSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEE 401
           +S +  G    +A       +    T   E ++NKEN+   S+ +D   LY       ++
Sbjct: 289 TSSVERGKEREEAWSFD-GALENKRTAAKESEENKENLIINSELKDDLLLY-------QD 340

Query: 402 DEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTK 461
           +E  + S+ + +L  K C+K+ LA+KL NRPSK+ELE++NI PR+TDEER E+RQQI  K
Sbjct: 341 EEALNDSIISGTLPRK-CKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMK 399

Query: 462 LTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIR 521
           L++RLSQRP  EELE+RNILK RN+Q EQEE+REIK+RLTRKL+QRPTV+ELR+RKILIR
Sbjct: 400 LSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIR 459

Query: 522 FSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           FSDYVEVA AQDYDRRADKPWTRL+AADKAAIRKELNE+KS EMEVH  S+HLTRFHRP
Sbjct: 460 FSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 518


>gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
           sapiens]
          Length = 554

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 351 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 405

Query: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 406 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 465

Query: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 466 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 524

Query: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 525 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 554



 Score =  110 bits (276), Expect = 3e-24
 Identities = 51/96 (53%), Positives = 73/96 (76%), Gaps = 1/96 (1%)

Query: 83  AAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAALE 141
           A + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA LE
Sbjct: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63

Query: 142 RKISMRQSREELIKRGVLKEIYDKDGELSISNEEDS 177
           RKIS RQSREELI+RGVLKE+ D+DG+++++ E  +
Sbjct: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSN 99



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 334 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 393

Query: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 394 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 449

Query: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 450 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 489


>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
           sapiens]
          Length = 634

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 431 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 485

Query: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 486 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 545

Query: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 546 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 604

Query: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 605 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 634



 Score =  117 bits (294), Expect = 2e-26
 Identities = 147/559 (26%), Positives = 234/559 (41%), Gaps = 70/559 (12%)

Query: 83  AAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAALE 141
           A + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA LE
Sbjct: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63

Query: 142 RKISMRQSREELIKRGVLKEIYDKDGELSISNE----------EDSLENGQSLSSSQLSL 191
           RKIS RQSREELI+RGVLKE+ D+DG+++++ E          E+S      + S + + 
Sbjct: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123

Query: 192 PALSEMEPVPMPRDPCSYEVLQPSDIMDGP--DPGAPVKLPCLPVKLSPPLPPKKVMICM 249
               +  P+    +         S+    P   P AP K    P     P+PPK      
Sbjct: 124 SVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGA 183

Query: 250 PVGGPDLSLVSYTAQKSGQQG------VAQHHHTVLPSQIQHQLQ-YGSHGQHLPSTTGS 302
              G ++  +    +  G+Q        A  + T   +   H  +  GS     PST+ +
Sbjct: 184 SHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSST 243

Query: 303 LPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGP--MGLP 360
                +    +     T+  T  + ++ +Q  P ++   S    SG    K  P    + 
Sbjct: 244 SSRPKASKETVSSKAGTVGTTKGKRKTDKQ--PITSHLSSDTTTSGTSDLKGEPAETRVE 301

Query: 361 EIRQVPTVVIECDDN----KENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLA- 415
             +   TV    + N    K  VP        S L      E++     D+ +   S+  
Sbjct: 302 SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGA 361

Query: 416 -MKVCRKDSLAIKLSNRPSKR---------ELEEKNILPRQTDEERLELRQQIGTK-LTR 464
            + V   D   +  +  P+ R          +  +N     T EE  +   Q+ T  L  
Sbjct: 362 DLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMG 421

Query: 465 RLSQRPTAEELE-----QRN-------ILKPRNEQEEQEE--------KREIKRR--LTR 502
             S+  +A E E     Q N       IL   +E E+++E          +I+RR  L  
Sbjct: 422 ESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAI 481

Query: 503 KLSQRPTVEELRERKILIRFSDYVEVADAQDYD-----RRADKPWTRLTAADKAAIRKEL 557
           KL  RP+ +EL ++ IL R S+       Q        R + +P T     ++  I K+ 
Sbjct: 482 KLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTE--ELEQRNILKQK 539

Query: 558 NEFKSTEMEVHELSRHLTR 576
           NE +  E ++ EL R L+R
Sbjct: 540 NEEEEQEAKM-ELKRRLSR 557



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 414 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 473

Query: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 474 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 529

Query: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 530 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 569


>gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
           sapiens]
          Length = 565

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 362 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 416

Query: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 417 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 476

Query: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 477 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 535

Query: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 536 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 565



 Score =  112 bits (279), Expect = 1e-24
 Identities = 51/97 (52%), Positives = 74/97 (76%), Gaps = 1/97 (1%)

Query: 82  GAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAAL 140
           G+ + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA L
Sbjct: 14  GSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVL 73

Query: 141 ERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDS 177
           ERKIS RQSREELI+RGVLKE+ D+DG+++++ E  +
Sbjct: 74  ERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSN 110



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 345 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 404

Query: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 405 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 460

Query: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 461 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 500


>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
           sapiens]
          Length = 645

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 442 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 496

Query: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 497 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 556

Query: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 557 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 615

Query: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 616 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 645



 Score =  119 bits (297), Expect = 1e-26
 Identities = 147/560 (26%), Positives = 235/560 (41%), Gaps = 70/560 (12%)

Query: 82  GAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAAL 140
           G+ + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA L
Sbjct: 14  GSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVL 73

Query: 141 ERKISMRQSREELIKRGVLKEIYDKDGELSISNE----------EDSLENGQSLSSSQLS 190
           ERKIS RQSREELI+RGVLKE+ D+DG+++++ E          E+S      + S + +
Sbjct: 74  ERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGN 133

Query: 191 LPALSEMEPVPMPRDPCSYEVLQPSDIMDGP--DPGAPVKLPCLPVKLSPPLPPKKVMIC 248
                +  P+    +         S+    P   P AP K    P     P+PPK     
Sbjct: 134 GSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAG 193

Query: 249 MPVGGPDLSLVSYTAQKSGQQG------VAQHHHTVLPSQIQHQLQ-YGSHGQHLPSTTG 301
               G ++  +    +  G+Q        A  + T   +   H  +  GS     PST+ 
Sbjct: 194 ASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSS 253

Query: 302 SLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGP--MGL 359
           +     +    +     T+  T  + ++ +Q  P ++   S    SG    K  P    +
Sbjct: 254 TSSRPKASKETVSSKAGTVGTTKGKRKTDKQ--PITSHLSSDTTTSGTSDLKGEPAETRV 311

Query: 360 PEIRQVPTVVIECDDN----KENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLA 415
              +   TV    + N    K  VP        S L      E++     D+ +   S+ 
Sbjct: 312 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG 371

Query: 416 --MKVCRKDSLAIKLSNRPSKR---------ELEEKNILPRQTDEERLELRQQIGTK-LT 463
             + V   D   +  +  P+ R          +  +N     T EE  +   Q+ T  L 
Sbjct: 372 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM 431

Query: 464 RRLSQRPTAEELE-----QRN-------ILKPRNEQEEQEE--------KREIKRR--LT 501
              S+  +A E E     Q N       IL   +E E+++E          +I+RR  L 
Sbjct: 432 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA 491

Query: 502 RKLSQRPTVEELRERKILIRFSDYVEVADAQDYD-----RRADKPWTRLTAADKAAIRKE 556
            KL  RP+ +EL ++ IL R S+       Q        R + +P T     ++  I K+
Sbjct: 492 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTE--ELEQRNILKQ 549

Query: 557 LNEFKSTEMEVHELSRHLTR 576
            NE +  E ++ EL R L+R
Sbjct: 550 KNEEEEQEAKM-ELKRRLSR 568



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 425 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 484

Query: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 485 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 540

Query: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 541 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 580


>gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo
           sapiens]
          Length = 712

 Score =  261 bits (666), Expect = 2e-69
 Identities = 177/381 (46%), Positives = 222/381 (58%), Gaps = 42/381 (11%)

Query: 221 PDPGAPVKLPCLPVKLSPPLPPKKVMICMPVG-GPDLSLVSYTAQKSGQQGVAQHHHTVL 279
           P P  P  +P  P + +PP P K   +   +   P L L     Q+  Q+         +
Sbjct: 353 PSPPLPTHIPPEPPR-TPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQK-------KEV 404

Query: 280 PSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTS 339
           P +I  Q  +G    H+PS    LP+H    R+   L   L MT   LE S +    S  
Sbjct: 405 PKRILDQ-NFGE--PHIPSRLPPLPLH---IRIQQALTSPLPMT-PILEGSHRAH--SLL 455

Query: 340 YHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDS---------SC 390
           + +S   S D  T      LP   ++  V  + ++ ++  P     E +          C
Sbjct: 456 FENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQC 515

Query: 391 LYTREEEEEEED-----------EDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEE 439
           L  REEEE+E D           E+D+   Y S+LA KV RKD+LA+KL++RPS+ EL  
Sbjct: 516 L--REEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELN- 572

Query: 440 KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRR 499
            N  P ++ EE  E+R QIG  L RRLSQRPT EELEQRNIL+P+NE + Q EKREIKRR
Sbjct: 573 LNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRR 632

Query: 500 LTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNE 559
           LTRKLSQRPTV EL  RKIL RF++YVEV DAQDYDRRADKPWT+LT ADKAAIRKELNE
Sbjct: 633 LTRKLSQRPTVAELLARKIL-RFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNE 691

Query: 560 FKSTEMEVHELSRHLTRFHRP 580
           FKS+EMEVHE S+H TR+HRP
Sbjct: 692 FKSSEMEVHEESKHFTRYHRP 712



 Score =  110 bits (274), Expect = 5e-24
 Identities = 73/173 (42%), Positives = 97/173 (56%), Gaps = 8/173 (4%)

Query: 80  NLGAAEEVERLAA---MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKS-EKFKH 135
           N  A EE ++      M  DS+  G  TPP +R+SKF+  G+IFKPWKWRKKKS +KFK 
Sbjct: 11  NPDAVEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKE 70

Query: 136 TSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQS--LSSSQLSLPA 193
           TS  LERKISMR+ REEL+KRGVL E  ++ GE      +  L+NG +  + +++ S P 
Sbjct: 71  TSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPV 130

Query: 194 LSEMEPVPMP--RDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKK 244
             E EPV +   R     E L+      G  P +  +     V   P LPPK+
Sbjct: 131 QVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKR 183


>gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo
           sapiens]
          Length = 702

 Score =  261 bits (666), Expect = 2e-69
 Identities = 177/381 (46%), Positives = 222/381 (58%), Gaps = 42/381 (11%)

Query: 221 PDPGAPVKLPCLPVKLSPPLPPKKVMICMPVG-GPDLSLVSYTAQKSGQQGVAQHHHTVL 279
           P P  P  +P  P + +PP P K   +   +   P L L     Q+  Q+         +
Sbjct: 343 PSPPLPTHIPPEPPR-TPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQK-------KEV 394

Query: 280 PSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTS 339
           P +I  Q  +G    H+PS    LP+H    R+   L   L MT   LE S +    S  
Sbjct: 395 PKRILDQ-NFGE--PHIPSRLPPLPLH---IRIQQALTSPLPMT-PILEGSHRAH--SLL 445

Query: 340 YHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDS---------SC 390
           + +S   S D  T      LP   ++  V  + ++ ++  P     E +          C
Sbjct: 446 FENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQC 505

Query: 391 LYTREEEEEEED-----------EDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEE 439
           L  REEEE+E D           E+D+   Y S+LA KV RKD+LA+KL++RPS+ EL  
Sbjct: 506 L--REEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELN- 562

Query: 440 KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRR 499
            N  P ++ EE  E+R QIG  L RRLSQRPT EELEQRNIL+P+NE + Q EKREIKRR
Sbjct: 563 LNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRR 622

Query: 500 LTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNE 559
           LTRKLSQRPTV EL  RKIL RF++YVEV DAQDYDRRADKPWT+LT ADKAAIRKELNE
Sbjct: 623 LTRKLSQRPTVAELLARKIL-RFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNE 681

Query: 560 FKSTEMEVHELSRHLTRFHRP 580
           FKS+EMEVHE S+H TR+HRP
Sbjct: 682 FKSSEMEVHEESKHFTRYHRP 702



 Score =  109 bits (272), Expect = 8e-24
 Identities = 68/154 (44%), Positives = 90/154 (58%), Gaps = 5/154 (3%)

Query: 96  DSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKS-EKFKHTSAALERKISMRQSREELI 154
           DS+  G  TPP +R+SKF+  G+IFKPWKWRKKKS +KFK TS  LERKISMR+ REEL+
Sbjct: 20  DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 79

Query: 155 KRGVLKEIYDKDGELSISNEEDSLENGQS--LSSSQLSLPALSEMEPVPMP--RDPCSYE 210
           KRGVL E  ++ GE      +  L+NG +  + +++ S P   E EPV +   R     E
Sbjct: 80  KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEE 139

Query: 211 VLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKK 244
            L+      G  P +  +     V   P LPPK+
Sbjct: 140 DLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKR 173


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 14/208 (6%)

Query: 376 KENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKR 435
           K     E++YE S    + EEEEE  +++ + S   +       R+D L ++  N+    
Sbjct: 312 KRGEKDETEYEYSG---SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 436 ELEEKNILPRQTDEERLELRQQIGTKLTRRL----SQRPTAEELEQRNILKPRNEQEEQE 491
            L  + +L  Q   E+ E ++Q+  +  +R+     QR   EE ++R     R ++ EQ 
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 492 EKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRR-ADKPWTRLTAADK 550
            + + ++R   +L +R   EE R R       +   V   Q+Y RR  ++    L    +
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRR----AEEEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484

Query: 551 AAIRKE--LNEFKSTEMEVHELSRHLTR 576
             ++++  L E +  EME H  +  L R
Sbjct: 485 QLLQEQAMLLECRWREMEEHRQAERLQR 512


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 45/184 (24%), Positives = 86/184 (46%), Gaps = 21/184 (11%)

Query: 376 KENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKR 435
           K     E++YE S    + EEEEE  +++ + S   +       R+D L ++  N+    
Sbjct: 312 KRGEKDETEYEYSG---SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 436 ELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKRE 495
            L  + +L  Q   E+ E ++Q+  +  +R+ Q     + EQR     R  +E+Q  +RE
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ-----QKEQR-----RRLEEQQRRERE 418

Query: 496 IKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRK 555
            +R+  R+  +R   E+ R  ++  R  +  E   A++  RR ++        ++  IR+
Sbjct: 419 ARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER--------EQEYIRR 470

Query: 556 ELNE 559
           +L E
Sbjct: 471 QLEE 474


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 45/184 (24%), Positives = 86/184 (46%), Gaps = 21/184 (11%)

Query: 376 KENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKR 435
           K     E++YE S    + EEEEE  +++ + S   +       R+D L ++  N+    
Sbjct: 312 KRGEKDETEYEYSG---SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 436 ELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKRE 495
            L  + +L  Q   E+ E ++Q+  +  +R+ Q     + EQR     R  +E+Q  +RE
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ-----QKEQR-----RRLEEQQRRERE 418

Query: 496 IKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRK 555
            +R+  R+  +R   E+ R  ++  R  +  E   A++  RR ++        ++  IR+
Sbjct: 419 ARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER--------EQEYIRR 470

Query: 556 ELNE 559
           +L E
Sbjct: 471 QLEE 474


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 66/314 (21%), Positives = 126/314 (40%), Gaps = 35/314 (11%)

Query: 172 SNEEDSLENGQSLSSSQLSLPALSEMEPVP-MPRDPCSYEVLQPSDIMDGPDPGAPVKLP 230
           S++  S    Q+ SS +  + A S+ E  P +P +P     ++P +  D   P  P  L 
Sbjct: 657 SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPADLT 713

Query: 231 CLPVKL------SPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHH-TVLPSQI 283
            L  +L          P KKV           S  S ++++  + G ++ H  TV  S I
Sbjct: 714 ALAKELRELRIEETNRPMKKV-----TDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 768

Query: 284 QHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLA----MTMQRLESSEQRVPCSTS 339
              +  G+ G +     G +  H       D  + +++    + ++     ++R   S S
Sbjct: 769 PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 828

Query: 340 YHSSG-LHSGDGVTKA-GPMGLPE--IRQVPTVVIECDDNKENVPHESD------YEDSS 389
              +G ++  D V ++  P G P   + +V T   E D   E     S       + D  
Sbjct: 829 NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 888

Query: 390 CLYTRE-EEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTD 448
              T   +E+EE++E   ++L+TS L     R++   +  + + S   +   NI P    
Sbjct: 889 VYQTSPTDEDEEDEESSAAALFTSEL----LRQEQAKLNEARKISVVNVNPTNIRPHSDT 944

Query: 449 EERLELRQQIGTKL 462
            E  + +++  +++
Sbjct: 945 PEIRKYKKRFNSEI 958


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 66/314 (21%), Positives = 126/314 (40%), Gaps = 35/314 (11%)

Query: 172 SNEEDSLENGQSLSSSQLSLPALSEMEPVP-MPRDPCSYEVLQPSDIMDGPDPGAPVKLP 230
           S++  S    Q+ SS +  + A S+ E  P +P +P     ++P +  D   P  P  L 
Sbjct: 686 SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPADLT 742

Query: 231 CLPVKL------SPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHH-TVLPSQI 283
            L  +L          P KKV           S  S ++++  + G ++ H  TV  S I
Sbjct: 743 ALAKELRELRIEETNRPMKKV-----TDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 797

Query: 284 QHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLA----MTMQRLESSEQRVPCSTS 339
              +  G+ G +     G +  H       D  + +++    + ++     ++R   S S
Sbjct: 798 PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 857

Query: 340 YHSSG-LHSGDGVTKA-GPMGLPE--IRQVPTVVIECDDNKENVPHESD------YEDSS 389
              +G ++  D V ++  P G P   + +V T   E D   E     S       + D  
Sbjct: 858 NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 917

Query: 390 CLYTRE-EEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTD 448
              T   +E+EE++E   ++L+TS L     R++   +  + + S   +   NI P    
Sbjct: 918 VYQTSPTDEDEEDEESSAAALFTSEL----LRQEQAKLNEARKISVVNVNPTNIRPHSDT 973

Query: 449 EERLELRQQIGTKL 462
            E  + +++  +++
Sbjct: 974 PEIRKYKKRFNSEI 987


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 66/314 (21%), Positives = 126/314 (40%), Gaps = 35/314 (11%)

Query: 172  SNEEDSLENGQSLSSSQLSLPALSEMEPVP-MPRDPCSYEVLQPSDIMDGPDPGAPVKLP 230
            S++  S    Q+ SS +  + A S+ E  P +P +P     ++P +  D   P  P  L 
Sbjct: 712  SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPADLT 768

Query: 231  CLPVKL------SPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHH-TVLPSQI 283
             L  +L          P KKV           S  S ++++  + G ++ H  TV  S I
Sbjct: 769  ALAKELRELRIEETNRPMKKV-----TDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 823

Query: 284  QHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLA----MTMQRLESSEQRVPCSTS 339
               +  G+ G +     G +  H       D  + +++    + ++     ++R   S S
Sbjct: 824  PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 883

Query: 340  YHSSG-LHSGDGVTKA-GPMGLPE--IRQVPTVVIECDDNKENVPHESD------YEDSS 389
               +G ++  D V ++  P G P   + +V T   E D   E     S       + D  
Sbjct: 884  NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 943

Query: 390  CLYTRE-EEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTD 448
               T   +E+EE++E   ++L+TS L     R++   +  + + S   +   NI P    
Sbjct: 944  VYQTSPTDEDEEDEESSAAALFTSEL----LRQEQAKLNEARKISVVNVNPTNIRPHSDT 999

Query: 449  EERLELRQQIGTKL 462
             E  + +++  +++
Sbjct: 1000 PEIRKYKKRFNSEI 1013


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 66/314 (21%), Positives = 126/314 (40%), Gaps = 35/314 (11%)

Query: 172  SNEEDSLENGQSLSSSQLSLPALSEMEPVP-MPRDPCSYEVLQPSDIMDGPDPGAPVKLP 230
            S++  S    Q+ SS +  + A S+ E  P +P +P     ++P +  D   P  P  L 
Sbjct: 741  SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPADLT 797

Query: 231  CLPVKL------SPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHH-TVLPSQI 283
             L  +L          P KKV           S  S ++++  + G ++ H  TV  S I
Sbjct: 798  ALAKELRELRIEETNRPMKKV-----TDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 852

Query: 284  QHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLA----MTMQRLESSEQRVPCSTS 339
               +  G+ G +     G +  H       D  + +++    + ++     ++R   S S
Sbjct: 853  PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 912

Query: 340  YHSSG-LHSGDGVTKA-GPMGLPE--IRQVPTVVIECDDNKENVPHESD------YEDSS 389
               +G ++  D V ++  P G P   + +V T   E D   E     S       + D  
Sbjct: 913  NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 972

Query: 390  CLYTRE-EEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTD 448
               T   +E+EE++E   ++L+TS L     R++   +  + + S   +   NI P    
Sbjct: 973  VYQTSPTDEDEEDEESSAAALFTSEL----LRQEQAKLNEARKISVVNVNPTNIRPHSDT 1028

Query: 449  EERLELRQQIGTKL 462
             E  + +++  +++
Sbjct: 1029 PEIRKYKKRFNSEI 1042


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/145 (24%), Positives = 70/145 (48%), Gaps = 9/145 (6%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           I+    K     E++YE     Y+  EEEEEE++  + S   +       R+D L ++L+
Sbjct: 306 IDRTKKKRGEKDETEYE-----YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 430 NRPSKRELEEKNI--LPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQ 487
           N+     L  + +    R+ +E + +L  +   ++  +  QR   EE ++R   K   +Q
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRRE--KELRKQ 418

Query: 488 EEQEEKREIKRRLTRKLSQRPTVEE 512
           +E+E++R  + ++ R+  +R    E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHE 443


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 7/186 (3%)

Query: 361  EIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMK--V 418
            E++Q    ++  +  K     E  Y +   L  ++ ++   DED  S L       K   
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234

Query: 419  CRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQR 478
             R + +  K       R+LE+  +  RQ+ ++   L+  +G +  R   Q       +QR
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD---LQHLLGEQQERDREQE--RRRWQQR 1289

Query: 479  NILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRA 538
            +   P  EQ E+EE++E KRR  +   ++  + E RE K   + +D     + Q    R 
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 539  DKPWTR 544
            ++P  R
Sbjct: 1350 EQPLRR 1355



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 32/158 (20%), Positives = 75/158 (47%), Gaps = 8/158 (5%)

Query: 361 EIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCR 420
           ++R+   +  E ++ +    HE +  +      +EE  +    ++++  +      +  +
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477

Query: 421 KDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI 480
           +D    +   R    +LEE+    R+  +ER E  QQ+  +   R  QR   +E E+R  
Sbjct: 478 RDQ---EEERRERWLKLEEEE---RREQQERRE--QQLRREQEERREQRLKRQEEEERLQ 529

Query: 481 LKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKI 518
            + R+EQ+ + E+ E + +L ++  ++   +E RE+++
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 29/136 (21%), Positives = 63/136 (46%), Gaps = 18/136 (13%)

Query: 382 ESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKN 441
           E ++     +  +EEE+ +E+E             ++  ++    KL  +  +RE +E+ 
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQR--------ELQEEEEQLRKLERQELRRERQEE- 293

Query: 442 ILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLT 501
               +  ++RL   QQ+     RR  +    E+ E+R   + R EQ+E+  +++++R   
Sbjct: 294 ----EQQQQRLRREQQL-----RRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344

Query: 502 RKLSQRPTVEELRERK 517
            +  Q+   E+  ER+
Sbjct: 345 ERREQQLRREQEEERR 360



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 36/134 (26%), Positives = 63/134 (47%), Gaps = 21/134 (15%)

Query: 396  EEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTD------E 449
            EEE+   E ++  L +     K   ++ L         ++E EE+ + P+Q D      E
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQL---------RQEREEQQLRPQQRDGKYRWEE 1825

Query: 450  ERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQE-----EQEEKREIKRRLTRKL 504
            E+L+L +Q   +L +   ++  AEE         R EQE     EQ+ ++E +R+L  + 
Sbjct: 1826 EQLQLEEQ-EQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH 1884

Query: 505  SQRPTVEELRERKI 518
             +R   EE R R++
Sbjct: 1885 IRRQQKEEQRHRQV 1898



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 14/137 (10%)

Query: 391 LYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPS---KRELEEKNILPRQT 447
           L  REEE+  E E  +  L          R+D L  +   R     KRE EE+     + 
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEE----RRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 448 DE-ERLELRQQIGTKLTR------RLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRL 500
           +E ERLE  ++   +L R      R  Q   +EE E+R   + R EQ+E+ E+R  +   
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 501 TRKLSQRPTVEELRERK 517
             +L QR   E   ER+
Sbjct: 665 EERLEQRLKREHEEERR 681



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 5/129 (3%)

Query: 391 LYTREEEEEEEDEDDDSSLYTSSLAM-KVCRKDSLAIKLSNRPSKRELEEKNILPRQTDE 449
           L   EE+ +EE+      L      + K+ R++    +      ++ L  +  L R+ +E
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 450 ERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPT 509
           ER E +++   +  RR  Q    EE  ++ + + + E+ EQ+ +RE +     +  +R  
Sbjct: 313 ERREQQEERREQQERREQQ----EERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368

Query: 510 VEELRERKI 518
            EE RE+++
Sbjct: 369 EEERREQQL 377



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 37/135 (27%), Positives = 64/135 (47%), Gaps = 10/135 (7%)

Query: 391 LYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEE 450
           L   EEE  E+ E  +  L       +  R+  L  +      ++ L  +  L R+ +E 
Sbjct: 489 LKLEEEERREQQERREQQLRREQ---EERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 451 RLEL--RQQIGTKLTRRLSQRPTAEELEQRN-ILKPRNEQEEQEEKRE----IKRRLTRK 503
           R +L  R++       R  QR   E+ E+R+ +LK   E+ +Q  KRE    +++RL R+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605

Query: 504 LSQRPTVEELRERKI 518
             +R   EE RE+++
Sbjct: 606 EVERLEQEERREQRL 620



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 43/181 (23%), Positives = 73/181 (40%), Gaps = 25/181 (13%)

Query: 421 KDSLAIKLSNRPSKRELEEKNILPRQTDEE----RLELRQQIGTKLTRRLSQRPTAEELE 476
           K+SL         +R  E ++   RQ +EE    R + RQ+   +L     Q    E LE
Sbjct: 106 KESLLQDRRQEEDQRRFEPRD---RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLE 162

Query: 477 QRN-------ILKPRNEQEEQEEKREIKRRLT----RKLSQRPTVEELRERKILI----- 520
           QR+       + + R E +E+EE+R  + +L      +  + P  E+LR R++L      
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 521 RFSDYVEVADAQD--YDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFH 578
           R     +  + QD  +    +K W +     +    K   E    + E+ E    L +  
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 579 R 579
           R
Sbjct: 283 R 283



 Score = 36.6 bits (83), Expect = 0.065
 Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 6/136 (4%)

Query: 386 EDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPR 445
           E+   L   E +E   +  ++          +  R+     +   +  +RE +E+    R
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER----R 328

Query: 446 QTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLS 505
           +  EER E  QQ+  +   R  Q+   E+ E+R   + R EQEE+  +++++R    +  
Sbjct: 329 EQQEERRE--QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386

Query: 506 QRPTVEELRERKILIR 521
           Q+   E+   R+  +R
Sbjct: 387 QQLRREQQLRREQQLR 402



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 41/215 (19%), Positives = 86/215 (40%), Gaps = 21/215 (9%)

Query: 370 IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
           +E ++ +E      + E+       + EE+EE               +  +++    +L 
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669

Query: 430 NRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEE 489
            R  KRE EE+       +EE+ + R++I +++ +   Q  +  +  Q  +     +QE 
Sbjct: 670 QR-LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728

Query: 490 QEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAAD 549
           Q  ++E + +  R+ S+    EE R  +              Q+ ++R D  W +  A +
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHR------------QQQEEEQRRDFTW-QWQAEE 775

Query: 550 KA-------AIRKELNEFKSTEMEVHELSRHLTRF 577
           K+       + R  L E +  ++   E  +   RF
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 4/141 (2%)

Query: 381  HESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIK--LSNRPSKRELE 438
            H    E+   L  REE++    E D   L       +  R      +   S  P ++ LE
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519

Query: 439  EKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKR 498
            E+  L RQ   +R  L+++   +   R  QR    + + R   + R E+EEQ+  R+ + 
Sbjct: 1520 EEQQLHRQ-QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 499  RLTRKLSQRPTVEELRERKIL 519
            R  R   Q+   +E +ERK +
Sbjct: 1579 RKFRLEEQKVRRQE-QERKFM 1598



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 28/126 (22%), Positives = 62/126 (49%), Gaps = 7/126 (5%)

Query: 394  REEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLE 453
            R +E + +  +++  L       K  +++    +L  +  +R+  E+  L ++T++E+L 
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQ---QLRRQELERKFREEEQLRQETEQEQLR 1741

Query: 454  LRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEEL 513
             RQ+   K+      RP  EE + R   + R  +EE++ ++E   R  ++L  + +  + 
Sbjct: 1742 -RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE---REEQQLRSQESDRKF 1797

Query: 514  RERKIL 519
            RE + L
Sbjct: 1798 REEEQL 1803



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 38/153 (24%), Positives = 68/153 (44%), Gaps = 16/153 (10%)

Query: 380  PHESDYEDSSCLYTREEEEEEEDE----DDDSSLYTSSLAMKVCRKDSLAIK----LSNR 431
            P +   ++    Y  EEE ++E+E    ++           +  +KD L  +    L   
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037

Query: 432  PSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQE 491
              KR L+E+    R+ +E + E  Q +G +   R  Q     ELE++   +   +QEE++
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ-----ELERQYRKEEELQQEEEQ 1092

Query: 492  ---EKREIKRRLTRKLSQRPTVEELRERKILIR 521
               E+ E +RR  R+   R   E  +E + L+R
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 41/186 (22%), Positives = 75/186 (40%), Gaps = 16/186 (8%)

Query: 394 REEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLE 453
           R E+EEE  E             +  R++    +      +++L  +  L R   E++L 
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR---EQQLR 408

Query: 454 LRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEEL 513
             QQ+  +   R  Q+   E+ E+R+  K   E+ EQ  KRE + R      +  T    
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468

Query: 514 RERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRH 573
           +ER+         ++   Q+ +RR  + W +L   +    R+E  E +  ++   +  R 
Sbjct: 469 QERR-------KQQLKRDQEEERR--ERWLKLEEEE----RREQQERREQQLRREQEERR 515

Query: 574 LTRFHR 579
             R  R
Sbjct: 516 EQRLKR 521



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 37/141 (26%), Positives = 66/141 (46%), Gaps = 16/141 (11%)

Query: 392  YTREEEEEEEDE----DDDSSLYTSSLAMKVCRKDSLAIK----LSNRPSKRELEEKNIL 443
            Y  EEE ++E+E    ++  +     L  +  +++ L  +    L   P KR  +E+   
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE-- 1107

Query: 444  PRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQE---EKREIKRRL 500
             RQ  EE  E  QQ   +L R   ++   +ELE++   +   +QEE++   E+ E +RR 
Sbjct: 1108 -RQCREE--EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164

Query: 501  TRKLSQRPTVEELRERKILIR 521
              +   R   E  +E + L+R
Sbjct: 1165 ELERQYREEEELQQEEEQLLR 1185



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 38/164 (23%), Positives = 71/164 (43%), Gaps = 31/164 (18%)

Query: 392  YTREEEEEEEDED---DDSSLYTSSLAMKVCRKDS--------LAIKLSNRPSKRELEEK 440
            Y +EEE ++E+E    ++          + CR++         L  +   +  ++ELE +
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139

Query: 441  NILPRQTDEERLELRQQIGTKLTRRLSQRP--TAEELEQRNILKPRNEQEEQEEKREIKR 498
                 +  +E  +L ++   K  R+  +R     EEL+Q      R EQE++ ++RE + 
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199

Query: 499  RLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPW 542
            R           EEL+ +K   R+         +D D+R+D  W
Sbjct: 1200 R---------EEEELQRQKRKQRY---------RDEDQRSDLKW 1225



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 30/128 (23%), Positives = 59/128 (46%), Gaps = 9/128 (7%)

Query: 394 REEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLE 453
           REE++++  E  D          K  RK    ++   +  ++  EE+    R+  EE  +
Sbjct: 223 REEKQQQRRERQDRVFQEEE--EKEWRKRETVLR---KEEEKLQEEEPQRQRELQEEEEQ 277

Query: 454 LRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEEL 513
           LR+    +L R   +    EE +Q+ + + +  + +QEE+R  ++   R+  +R   +E 
Sbjct: 278 LRKLERQELRRERQE----EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333

Query: 514 RERKILIR 521
           R  + L R
Sbjct: 334 RREQQLRR 341



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 30/156 (19%), Positives = 73/156 (46%), Gaps = 13/156 (8%)

Query: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDE-------DDDSSLYTSSLAMKVCRKDS 423
           E ++ +     E  +++    + +++EEE+  +       ++ S      L+ +   ++ 
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793

Query: 424 LAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKP 483
              +L  R  +R+  E+  LP + ++E+   +++   K  + L +    +  E+   L+ 
Sbjct: 794 RERQL--RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 484 RNE--QEEQEEKREIKRRLTRKLSQRPTVEELRERK 517
             +  QE+QE +R  ++R  +K   R  +EE R+R+
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQK--WRWQLEEERKRR 885



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 7/128 (5%)

Query: 394 REEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLE 453
           RE E+E +  +++  L     A ++  ++    +   R   +E         Q +EER  
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884

Query: 454 LRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEEL 513
            R  +  K   +       E+L +   L    E+E Q E+RE +RR  ++   R   +  
Sbjct: 885 RRHTLYAKPALQ-------EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937

Query: 514 RERKILIR 521
           +E + L+R
Sbjct: 938 QEEEQLLR 945



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 34/152 (22%), Positives = 65/152 (42%), Gaps = 13/152 (8%)

Query: 391 LYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNI--LPRQTD 448
           L  ++EEE  E +++           +  R+  L         +RE EE+    L R+ +
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQL---------RREQEERREQQLRREQE 356

Query: 449 EERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRP 508
           EER E + +   +  RR  Q    ++L +   L  R EQ+ + E++  + +  R+  Q  
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLR 414

Query: 509 TVEELRERKILIRFSDYVEVADAQDYDRRADK 540
             ++LR  + L R  +        + +RR  +
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQR 446



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 32/179 (17%), Positives = 74/179 (41%), Gaps = 21/179 (11%)

Query: 399  EEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQI 458
            EEE +    +LY      +  RK+   ++          EE+  L R+  E+R    Q+ 
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQ----------EEEEELQREEREKRRRQEQER 928

Query: 459  GTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKI 518
              +   +L Q       E+R   + +  + +  + ++++++  + L + P     +ER+ 
Sbjct: 929  QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988

Query: 519  LIRFSDYVEVADAQ----DYDRRADKPWTR-------LTAADKAAIRKELNEFKSTEME 566
              R  + ++  + Q    + ++R  + W R       L   ++  +R+E  + +  E E
Sbjct: 989  KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 34/165 (20%), Positives = 68/165 (41%), Gaps = 16/165 (9%)

Query: 386  EDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPR 445
            ED   L  REE++    E D   L       +  R+  L          R+  E+  L +
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL-----RHDRDRKFREEEQLLQ 1677

Query: 446  QTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLS 505
            + +E+  +LR+Q   +  R   Q+   +E E++ +         QEE++  ++ L RK  
Sbjct: 1678 EGEEQ--QLRRQERDRKFREEEQQLRRQERERKFL---------QEEQQLRRQELERKFR 1726

Query: 506  QRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550
            +   + +  E++ L R   Y ++ + +      ++   R    D+
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771



 Score = 30.4 bits (67), Expect = 4.7
 Identities = 34/183 (18%), Positives = 79/183 (43%), Gaps = 7/183 (3%)

Query: 394 REEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAI-----KLSNRPSKRELEEKNILPRQTD 448
           R+E+E E  E ++ S     L  +  ++    +     +   R  +R  EE+    +  +
Sbjct: 141 RQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHE 200

Query: 449 EERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRP 508
            E     +Q+  +    L ++   E+ +QR   + R  QEE+E++   +  + RK  ++ 
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260

Query: 509 TVEELRERKILIRFSDYVEVADAQDY--DRRADKPWTRLTAADKAAIRKELNEFKSTEME 566
             EE + ++ L    + +   + Q+   +R+ ++   +    ++   RK+  E +  + E
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320

Query: 567 VHE 569
             E
Sbjct: 321 RRE 323



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 34/152 (22%), Positives = 66/152 (43%), Gaps = 3/152 (1%)

Query: 370  IECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLS 429
            +E ++ KE    +   ++   L   E EE+   ++ D         ++   +  L  +  
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358

Query: 430  NRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQR-NILKPRNEQE 488
            +R  + E        R+  EE   LR+Q   +   +  Q+   +E EQ+    + R  +E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418

Query: 489  EQEE-KREIKRRLTRKLSQRPTVEELRERKIL 519
            E+++  R+ + R  R+  Q+   +E RERK L
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQE-RERKFL 1449


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 25/168 (14%)

Query: 392 YTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEE- 450
           Y RE+  E+  E+DDS      LA+K  ++ S   K+ +R  ++  E+K+   ++ + E 
Sbjct: 67  YRREDSMEDRGEEDDS------LAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120

Query: 451 -------------RLELRQQIGTKLTRRLS--QRPTAEELEQRNIL--KPRNEQEEQEEK 493
                        R E  +Q   ++ R  S  +R   E+LE++     K R +Q+EQ E+
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 180

Query: 494 REIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKP 541
           +E +RR   +  +R    E+      +R  DY +   A  + R   +P
Sbjct: 181 KERERRAEERRKEREARREVSAHHRTMR-EDYSDKVKASHWSRSPPRP 227



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 35/110 (31%), Positives = 52/110 (47%), Gaps = 10/110 (9%)

Query: 480 ILKPRNEQEEQEEKREIKR--RLTRKLSQRPTVE--ELRER--KILIRFSDYVEVADAQD 533
           IL+ +  ++EQEEK EIKR      + S+R ++E  ELR+   +I IR S Y      +D
Sbjct: 16  ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMED 75

Query: 534 Y----DRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHR 579
                D  A KP  +++  +K   RK+    +     V E  R   R  R
Sbjct: 76  RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKR 125


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 25/168 (14%)

Query: 392 YTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEE- 450
           Y RE+  E+  E+DDS      LA+K  ++ S   K+ +R  ++  E+K+   ++ + E 
Sbjct: 33  YRREDSMEDRGEEDDS------LAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 86

Query: 451 -------------RLELRQQIGTKLTRRLS--QRPTAEELEQRNIL--KPRNEQEEQEEK 493
                        R E  +Q   ++ R  S  +R   E+LE++     K R +Q+EQ E+
Sbjct: 87  ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 146

Query: 494 REIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKP 541
           +E +RR   +  +R    E+      +R  DY +   A  + R   +P
Sbjct: 147 KERERRAEERRKEREARREVSAHHRTMR-EDYSDKVKASHWSRSPPRP 193


>gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo
           sapiens]
          Length = 373

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 50/243 (20%), Positives = 109/243 (44%), Gaps = 30/243 (12%)

Query: 351 VTKAGPMGLPEIRQV-PTVVIECDDNKENV----PHESDYEDSSCLYTREEEEEEEDEDD 405
           +T A   GL  +R   P + + C ++  ++     H+S   D       +EE+ +++ED 
Sbjct: 37  MTGARGQGLEVVRSPSPPLPLSCSNSTRSLLSPLGHQSFQFDEDDGDGEDEEDVDDEEDV 96

Query: 406 DSSLYTSS--------LAMKVCRKDSLAIKLSNRPSKR-ELEEKNILPRQT------DEE 450
           D   + S         + ++ C    +  + +    K+  L E  + P +        EE
Sbjct: 97  DEDAHDSEAKVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEE 156

Query: 451 RLELRQQIGTKLTRRLSQRPTAEELEQRNIL---------KPRNEQEEQEEKREIKRRLT 501
           R  L+ +   +L ++L +R   EE E+R I+         + +NEQ+ +E +++I + + 
Sbjct: 157 RDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEME 216

Query: 502 RKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFK 561
            K ++    E L+E K   ++ ++++  +A++ +R+  +         +   +KE+ E K
Sbjct: 217 EKAAKELEKEYLQE-KAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKK 275

Query: 562 STE 564
             E
Sbjct: 276 FQE 278


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 44/167 (26%), Positives = 75/167 (44%), Gaps = 24/167 (14%)

Query: 392 YTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSK-------------RELE 438
           Y RE+  E+  E+DDS      LA+K  ++ S   K+ +R  +             RE E
Sbjct: 67  YRREDSMEDRGEEDDS------LAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 120

Query: 439 EKNILPRQTDEERLELRQQIGTKLTRRLS--QRPTAEELEQRNIL--KPRNEQEEQEEKR 494
            +     + D+ R E  +Q   ++ R  S  +R   E+LE++     K R +Q+EQ E++
Sbjct: 121 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 180

Query: 495 EIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKP 541
           E +RR   +  +R    E+      +R  DY +   A  + R   +P
Sbjct: 181 ERERRAEERRKEREARREVSAHHRTMR-EDYSDKVKASHWSRSPPRP 226



 Score = 32.7 bits (73), Expect = 0.94
 Identities = 36/111 (32%), Positives = 53/111 (47%), Gaps = 11/111 (9%)

Query: 480 ILKPRNEQEEQEEKREIKR--RLTRKLSQRPTVE--ELRER--KILIRFSDYVEVADAQD 533
           IL+ +  ++EQEEK EIKR      + S+R ++E  ELR+   +I IR S Y      +D
Sbjct: 16  ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMED 75

Query: 534 Y----DRRADKPWTRLTAADKAAIRK-ELNEFKSTEMEVHELSRHLTRFHR 579
                D  A KP  +++  +K   RK E  + K     V E      + HR
Sbjct: 76  RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHR 126


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 40/301 (13%)

Query: 256 LSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQL-----QYG------SHGQHLPSTTGSLP 304
           L    +  Q+   Q +AQ     L SQ Q QL     Q+       S    +PS T S+ 
Sbjct: 619 LQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVS 678

Query: 305 MHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQ 364
           +  +G   I EL  T +        S   +P  T+     L     + KA    L + R+
Sbjct: 679 VPDTGS--IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERR 736

Query: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
              +  + ++ +     E   +    L  ++EEE +  E+++ +      A++  R+  +
Sbjct: 737 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEI 796

Query: 425 AIKLSNRPSKRELEE---KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI- 480
           A++      +R+ +E   + +  R+ +EE    ++++  K     ++    EE  QR + 
Sbjct: 797 ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 856

Query: 481 ----------LKPRNEQEEQEEK-------------REIKRRLTRKLSQRPTVEELRERK 517
                      + R+E+EE++ K             R+ ++   R+L Q+   ++L + K
Sbjct: 857 ENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 916

Query: 518 I 518
           +
Sbjct: 917 L 917


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 40/301 (13%)

Query: 256 LSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQL-----QYG------SHGQHLPSTTGSLP 304
           L    +  Q+   Q +AQ     L SQ Q QL     Q+       S    +PS T S+ 
Sbjct: 646 LQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVS 705

Query: 305 MHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQ 364
           +  +G   I EL  T +        S   +P  T+     L     + KA    L + R+
Sbjct: 706 VPDTGS--IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERR 763

Query: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
              +  + ++ +     E   +    L  ++EEE +  E+++ +      A++  R+  +
Sbjct: 764 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEI 823

Query: 425 AIKLSNRPSKRELEE---KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI- 480
           A++      +R+ +E   + +  R+ +EE    ++++  K     ++    EE  QR + 
Sbjct: 824 ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 883

Query: 481 ----------LKPRNEQEEQEEK-------------REIKRRLTRKLSQRPTVEELRERK 517
                      + R+E+EE++ K             R+ ++   R+L Q+   ++L + K
Sbjct: 884 ENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 943

Query: 518 I 518
           +
Sbjct: 944 L 944


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 40/301 (13%)

Query: 256 LSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQL-----QYG------SHGQHLPSTTGSLP 304
           L    +  Q+   Q +AQ     L SQ Q QL     Q+       S    +PS T S+ 
Sbjct: 625 LQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVS 684

Query: 305 MHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQ 364
           +  +G   I EL  T +        S   +P  T+     L     + KA    L + R+
Sbjct: 685 VPDTGS--IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERR 742

Query: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
              +  + ++ +     E   +    L  ++EEE +  E+++ +      A++  R+  +
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEI 802

Query: 425 AIKLSNRPSKRELEE---KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI- 480
           A++      +R+ +E   + +  R+ +EE    ++++  K     ++    EE  QR + 
Sbjct: 803 ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862

Query: 481 ----------LKPRNEQEEQEEK-------------REIKRRLTRKLSQRPTVEELRERK 517
                      + R+E+EE++ K             R+ ++   R+L Q+   ++L + K
Sbjct: 863 ENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 922

Query: 518 I 518
           +
Sbjct: 923 L 923


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 60/301 (19%), Positives = 121/301 (40%), Gaps = 40/301 (13%)

Query: 256 LSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQL-----QYG------SHGQHLPSTTGSLP 304
           L    +  Q+   Q +AQ     L SQ Q QL     Q+       S    +PS T S+ 
Sbjct: 625 LQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVS 684

Query: 305 MHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQ 364
           +  +G   I EL  T +        S   +P  T+     L     + KA    L + R+
Sbjct: 685 VPDTGS--IWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERR 742

Query: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
              +  + ++ +     E   +    L  ++EEE +  E+++ +      A++  R+  +
Sbjct: 743 EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEI 802

Query: 425 AIKLSNRPSKRELEE---KNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNI- 480
           A++      +R+ +E   + +  R+ +EE    ++++  K     ++    EE  QR + 
Sbjct: 803 ALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862

Query: 481 ----------LKPRNEQEEQEEK-------------REIKRRLTRKLSQRPTVEELRERK 517
                      + R+E+EE++ K             R+ ++   R+L Q+   ++L + K
Sbjct: 863 ENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMK 922

Query: 518 I 518
           +
Sbjct: 923 L 923


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,551,816
Number of Sequences: 37866
Number of extensions: 1229686
Number of successful extensions: 13219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 478
Number of HSP's that attempted gapping in prelim test: 9618
Number of HSP's gapped (non-prelim): 2463
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.