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Search of human proteins with 53729363
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|53729363 leucine rich repeat and sterile alpha motif
containing 1 [Homo sapiens]
(723 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|53729363 leucine rich repeat and sterile alpha motif containi... 1409 0.0
gi|53729361 leucine rich repeat and sterile alpha motif containi... 1409 0.0
gi|53729359 leucine rich repeat and sterile alpha motif containi... 1409 0.0
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 99 1e-20
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 97 7e-20
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 94 3e-19
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 89 2e-17
gi|238908508 leucine-rich repeat and death domain-containing pro... 88 2e-17
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 87 4e-17
gi|61742786 leucine rich repeat and death domain containing prot... 86 9e-17
gi|61742784 leucine rich repeat and death domain containing prot... 86 9e-17
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 86 9e-17
gi|61742782 leucine rich repeat and death domain containing prot... 83 8e-16
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 82 2e-15
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 82 2e-15
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 81 3e-15
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 80 7e-15
gi|45827729 scribble isoform b [Homo sapiens] 80 7e-15
gi|45827731 scribble isoform a [Homo sapiens] 80 7e-15
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 80 7e-15
gi|148746195 trichohyalin [Homo sapiens] 80 9e-15
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 79 1e-14
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 79 1e-14
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 79 1e-14
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 79 1e-14
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 79 1e-14
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 79 1e-14
gi|221139761 zinc finger protein 853 [Homo sapiens] 78 3e-14
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 78 3e-14
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 77 7e-14
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 1409 bits (3646), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL
Sbjct: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
Query: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP
Sbjct: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
Query: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL
Sbjct: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
Query: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD
Sbjct: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
Query: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK
Sbjct: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
Query: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE
Sbjct: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
Query: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS
Sbjct: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
Query: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET
Sbjct: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
Query: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS
Sbjct: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
Query: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL
Sbjct: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
Query: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR
Sbjct: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
Query: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY
Sbjct: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
Query: 721 HSS 723
HSS
Sbjct: 721 HSS 723
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 1409 bits (3646), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL
Sbjct: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
Query: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP
Sbjct: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
Query: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL
Sbjct: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
Query: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD
Sbjct: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
Query: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK
Sbjct: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
Query: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE
Sbjct: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
Query: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS
Sbjct: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
Query: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET
Sbjct: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
Query: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS
Sbjct: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
Query: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL
Sbjct: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
Query: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR
Sbjct: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
Query: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY
Sbjct: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
Query: 721 HSS 723
HSS
Sbjct: 721 HSS 723
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 1409 bits (3646), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL
Sbjct: 1 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 60
Query: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP
Sbjct: 61 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 120
Query: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL
Sbjct: 121 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
Query: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD
Sbjct: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 240
Query: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK
Sbjct: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
Query: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE
Sbjct: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 360
Query: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS
Sbjct: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
Query: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET
Sbjct: 421 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 480
Query: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS
Sbjct: 481 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 540
Query: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL
Sbjct: 541 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 600
Query: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR
Sbjct: 601 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 660
Query: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY
Sbjct: 661 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 720
Query: 721 HSS 723
HSS
Sbjct: 721 HSS 723
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 99.0 bits (245), Expect = 1e-20
Identities = 95/364 (26%), Positives = 168/364 (46%), Gaps = 49/364 (13%)
Query: 32 DILDISKCELSEIPFGAF--ATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLA-------- 81
D+ DI++ +LS F A C+++ + L ++ N L L P +L +L
Sbjct: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
Query: 82 -----------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQ 130
++VL + +N+L ALP D+G L +L+ L+V N+L LP + L+ L+
Sbjct: 126 LSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
Query: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
LNV+ N+L LP+ +G+L +R L+ S N + R+P +R L+++ LD++ + PP
Sbjct: 186 DLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
Query: 191 EVCGAGTAAILQFLCKESGL--------------EYYP-PSQYLLPILEQD-GIENSRDS 234
+VC G I ++L E+G + P P++ L P D G+++ S
Sbjct: 245 QVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHS 304
Query: 235 PDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQRE----HTQLLQQSSS 290
D + R+S E + FS+ R + E R E G + +
Sbjct: 305 VDSGSKRWSGNES--TDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVP 362
Query: 291 QKDEILQTVKEEQ-SRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQ 349
+DE TV+E++ L G + +R ++ R E+ E+ +Q + +RQ
Sbjct: 363 GEDEERGTVEEQRPPELSPGAGDRERAPSSRR----EEPAGEERRRPDTLQLWQERERRQ 418
Query: 350 KKSS 353
++ S
Sbjct: 419 QQQS 422
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 96.7 bits (239), Expect = 7e-20
Identities = 55/159 (34%), Positives = 95/159 (59%), Gaps = 5/159 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
L++ +++IPFG F+ KVL K L + N LTSL + S+ L+L NQL
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSK--LNMKDNQLTSLPLDFGTWTSMVE---LNLATNQL 414
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
T +P+D+ L +L+VL + N L +LP +GNL +L+ L++++NKL+ LP+ + L+ L+
Sbjct: 415 TKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQ 474
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
L ++ N++ LP+ + H+ L L L + + + P E+
Sbjct: 475 KLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
Score = 86.3 bits (212), Expect = 9e-17
Identities = 49/149 (32%), Positives = 86/149 (57%), Gaps = 6/149 (4%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
+LD+ +L EIP + ++ L + N +T++ + +L+ + +L + +N+
Sbjct: 173 MLDLRHNKLREIPSVVY---RLDSLTTLYLRFNRITTV---EKDIKNLSKLSMLSIRENK 226
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSL 152
+ LP ++G+L L L+V NQL LP+ IGN TQ+ L+++ N+L +LPDT+G L SL
Sbjct: 227 IKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSL 286
Query: 153 RTLNISGNEIQRLPQMLAHVRTLEMLSLD 181
L + N + +P+ LA LE L+L+
Sbjct: 287 SRLGLRYNRLSAIPRSLAKCSALEELNLE 315
Score = 79.0 bits (193), Expect = 1e-14
Identities = 65/250 (26%), Positives = 122/250 (48%), Gaps = 34/250 (13%)
Query: 8 RKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHL 67
RK S A E C + + LD+SK + +P + ++ Q L +++N L
Sbjct: 82 RKKSSNAEVIKELNKCREENSMR---LDLSKRSIHILPS---SIKELTQLTELYLYSNKL 135
Query: 68 TSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP------- 120
SL + L++L T L L +N LT+LPD L L L++L++ N+L ++P
Sbjct: 136 QSLPAEVGCLVNLMT---LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLD 192
Query: 121 ----------------RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQR 164
+ I NL++L L++++NK+K+LP +GEL +L TL+++ N+++
Sbjct: 193 SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEH 252
Query: 165 LPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILE 224
LP+ + + + L L + ++ P + +++ + + + L P S LE
Sbjct: 253 LPKEIGNCTQITNLDLQHNELLDLPDTI--GNLSSLSRLGLRYNRLSAIPRSLAKCSALE 310
Query: 225 QDGIENSRDS 234
+ +EN+ S
Sbjct: 311 ELNLENNNIS 320
Score = 68.9 bits (167), Expect = 2e-11
Identities = 42/132 (31%), Positives = 74/132 (56%), Gaps = 5/132 (3%)
Query: 59 VLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
+L + N + L + L +L T LD+ NQL LP ++G T + L+++ N+L+
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLIT---LDVAHNQLEHLPKEIGNCTQITNLDLQHNELLD 275
Query: 119 LPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQ-MLAHVRTLEM 177
LP +IGNL+ L L ++ N+L +P ++ + +L LN+ N I LP+ +L+ + L
Sbjct: 276 LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS 335
Query: 178 LSLDASA-MVYP 188
L+L + +YP
Sbjct: 336 LTLARNCFQLYP 347
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 94.4 bits (233), Expect = 3e-19
Identities = 103/413 (24%), Positives = 180/413 (43%), Gaps = 58/413 (14%)
Query: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
K LQ + + +L S LPK L L KVL + +N+L ++P+++G+L L L++
Sbjct: 154 KNLQMLTYLNISRNLLSTLPKYLFDLPL---KVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
Query: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
N++ LP+ +G L L+ LN++ N L LPD +G+L L L+ S N++ +P +
Sbjct: 211 CNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIPVCYRKL 269
Query: 173 RTLEMLSLDASAMVYPPREVCGAGTAAILQFL-----CKES---------GLEYYPPSQY 218
L+++ LD + + PP ++C G I ++L C+ L PSQ
Sbjct: 270 HHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQP 329
Query: 219 LLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM-LEKLEFERRLELG 277
L +E D N PD + E+ R S E + + L E E
Sbjct: 330 LTDSME-DFYPNKNHGPDSGIGSDNGEK-----RLSTTEPSDDDTVSLHSQVSESNREQT 383
Query: 278 QREHTQLL-QQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNIS 336
R + ++ ++ SQKD+ + + + E + EQ +
Sbjct: 384 SRNDSHIIGSKTDSQKDQEVYDFVDPNT---------------------EDVAVPEQG-N 421
Query: 337 SRIQKLLQDNQRQKKSSEILKSLENERI----RMEQLMSITQEETESLRR-RDVASAMQQ 391
+ I + + ++K SE KS +NE + R+E+ + +EE + L+ D+ Q
Sbjct: 422 AHIGSFVSFFKGKEKCSE--KSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQ 479
Query: 392 MLTESCKNRLIQMAYESQRQNLVQQA-CSSMAEMDERFQQI--LSWQQMDQNK 441
+L + KNR++ + R Q C DE + L+WQ ++ K
Sbjct: 480 LLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQK 532
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 85 VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
+L L +L P LT ++ RN+ ++P + L+TLN+ N +K +P+
Sbjct: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
Query: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
+ L+ L LNIS N + LP+ L + L++L + + +V P E+ L
Sbjct: 152 AIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
Query: 205 CKE 207
C E
Sbjct: 211 CNE 213
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 72/418 (17%)
Query: 35 DISKCELSEIPFGA-----------FATC------KVLQKKVLI---VHTNHLTSLLPKS 74
D+S+ LSEIP A + C +L + L + N L++L
Sbjct: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
Query: 75 CSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNV 134
C+L +KVL +N+L +LP+++G L L L+V N++ +P IGNL L+ LNV
Sbjct: 148 CNL----PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
Query: 135 KDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
+ N L LP+ + EL +R L+ S N+I +P ++R L+ ++LD + + PP ++C
Sbjct: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICI 262
Query: 195 AGTAAILQFL----CK---------ESGLEYYPPSQYLL---PILEQDGIENSRDSPD-- 236
G I ++L CK L + + L P D NS DS D
Sbjct: 263 KGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKR 322
Query: 237 ----GPTDRFSREEL--------EWQNRFSDYEKRKEQKMLEKLEFERRLE--------L 276
PTD FS L + R S Y++ + ++ E L+
Sbjct: 323 WSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCT 382
Query: 277 GQREHTQLLQQSSSQKDEILQTVKE--EQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQN 334
+ E ++ Q D + EQ R+ S + E Q+ ++ + QN
Sbjct: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQN 442
Query: 335 -----ISSRIQKLLQDNQRQKKSSEILKSLEN--ERIRMEQLMSITQEETESLRRRDV 385
SS + NQ E+ + E ER R E ++ Q E E +R + +
Sbjct: 443 RVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQI 500
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 22/143 (15%)
Query: 72 PKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQT 131
P+ + L DL N+L+ +P + +L+ LN+ +N + +P +I NL L
Sbjct: 73 PRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTF 132
Query: 132 LNVKDNKLK----------------------ELPDTVGELRSLRTLNISGNEIQRLPQML 169
LN+ N+L LP+ +G LR L L++S NEIQ +P +
Sbjct: 133 LNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQI 192
Query: 170 AHVRTLEMLSLDASAMVYPPREV 192
++ L L++ + +V+ P E+
Sbjct: 193 GNLEALRDLNVRRNHLVHLPEEL 215
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 76 SLLSLATIKVLDLHDNQLTALPDDLGQ--LTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
+L A VL L +L P LT ++ RN+L ++P + L+ LN
Sbjct: 52 ALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLN 111
Query: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
+ N ++ +P+ + L++L LNIS N++ LP L ++ L++L + +V P E+
Sbjct: 112 LYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169
Score = 40.0 bits (92), Expect = 0.008
Identities = 23/88 (26%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 108 VLNVERNQLMQLPRSIGN--LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRL 165
VL++ +L + PR N LT ++ N+L E+P SL LN+ N I+ +
Sbjct: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
Query: 166 PQMLAHVRTLEMLSLDASAMVYPPREVC 193
P+ + +++ L L++ + + P +C
Sbjct: 121 PEAILNLQALTFLNISRNQLSTLPVHLC 148
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 88.2 bits (217), Expect = 2e-17
Identities = 48/161 (29%), Positives = 90/161 (55%), Gaps = 3/161 (1%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
+LD+S+ +L +I K +QK L +N + C L SL + + + +
Sbjct: 583 VLDLSENQLQKIS-SDICNLKGIQK--LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRK 639
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSL 152
LT LP +L +T L+ L++ N + ++PR+IG L L +L+ +N++ LP ++ L L
Sbjct: 640 LTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDL 699
Query: 153 RTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
+ LN+SGN + LP + ++ +L+ ++ D + ++ PP E+C
Sbjct: 700 QQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740
Score = 70.5 bits (171), Expect = 5e-12
Identities = 61/219 (27%), Positives = 104/219 (47%), Gaps = 12/219 (5%)
Query: 40 ELSEIPFGAFAT--CKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALP 97
ELSE F+ C ++ K L + N + + S+ ++ ++ VL L N+ P
Sbjct: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI---PASISNMISLHVLILCCNKFETFP 572
Query: 98 DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNI 157
+L L LQVL++ NQL ++ I NL +Q LN N+ P + +L+SL LNI
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Query: 158 S---GNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYP 214
S G ++ RLP L+++ L+ L + +A+ PR + ++ + + Y P
Sbjct: 633 SQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNI--GELRNLVSLHAYNNQISYLP 690
Query: 215 PSQYLLPILEQDGI--ENSRDSPDGPTDRFSREELEWQN 251
PS L L+Q + N P + FS +E+ + +
Sbjct: 691 PSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDD 729
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/162 (29%), Positives = 90/162 (55%), Gaps = 8/162 (4%)
Query: 32 DILDISKCELSEIPFGAFATCKVLQK-KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHD 90
+IL + + LS +P + ++L ++L V NH+ S +PK S L I+ L ++
Sbjct: 191 EILSLQENGLSSLP----SEIQLLHNLRILNVSHNHI-SHIPKEIS--QLGNIRQLFFYN 243
Query: 91 NQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELR 150
N + P DL L L++L++ +N+L +P ++ +L L+ LN++ N+L P + L
Sbjct: 244 NYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Query: 151 SLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
L +L+++GN I LP+ + ++ LE L +D + + + E+
Sbjct: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEI 345
Score = 66.6 bits (161), Expect = 8e-11
Identities = 37/135 (27%), Positives = 70/135 (51%), Gaps = 3/135 (2%)
Query: 58 KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
+ L++ N LT L + + L IK L L DN+L + + L++L +++N L
Sbjct: 329 ETLLMDHNKLTFL---AVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385
Query: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
+P I L+ L++ DNKL ELP + +L +LR L+++ N + ++ ++H+ +
Sbjct: 386 NIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICS 445
Query: 178 LSLDASAMVYPPREV 192
L + + P E+
Sbjct: 446 LEFSGNIITDVPIEI 460
Score = 66.2 bits (160), Expect = 1e-10
Identities = 31/114 (27%), Positives = 66/114 (57%)
Query: 80 LATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKL 139
L +++L L +N L++LP ++ L L++LNV N + +P+ I L ++ L +N +
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
Query: 140 KELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
+ P + L +L L++ N+++ +P L ++TL +L+L+ + + P+ +C
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
Score = 65.9 bits (159), Expect = 1e-10
Identities = 39/139 (28%), Positives = 75/139 (53%), Gaps = 3/139 (2%)
Query: 54 VLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVER 113
+L ++L + N L+SL P LL +++L++ N ++ +P ++ QL ++ L
Sbjct: 187 LLGLEILSLQENGLSSL-PSEIQLLH--NLRILNVSHNHISHIPKEISQLGNIRQLFFYN 243
Query: 114 NQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVR 173
N + P + L L+ L++ NKL+ +PDT+ L++LR LN+ N++ P+ L +
Sbjct: 244 NYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Query: 174 TLEMLSLDASAMVYPPREV 192
L L L + + P+E+
Sbjct: 304 KLISLDLTGNLISSLPKEI 322
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 32 DILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDN 91
+IL + K +L IP + K L +VL + N LT+ C L L + LDL N
Sbjct: 260 EILSLGKNKLRHIP-DTLPSLKTL--RVLNLEYNQLTTFPKALCFLPKLIS---LDLTGN 313
Query: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
+++LP ++ +L L+ L ++ N+L L I L +++ L + DNKL+ + + R
Sbjct: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
Query: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
LR L + N ++ +P+ ++ LE LSL + + P+ +
Sbjct: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414
Score = 64.7 bits (156), Expect = 3e-10
Identities = 42/147 (28%), Positives = 76/147 (51%), Gaps = 6/147 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
L ++ +SEIP + ++L L + N L CSL++L K LDL NQ+
Sbjct: 492 LSVNGNYISEIPVDISFSKQLLH---LELSENKLLIFSEHFCSLINL---KYLDLGKNQI 545
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+P + + +L VL + N+ PR + L LQ L++ +N+L+++ + L+ ++
Sbjct: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSL 180
LN S N+ P L +++LE L++
Sbjct: 606 KLNFSSNQFIHFPIELCQLQSLEQLNI 632
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/148 (29%), Positives = 71/148 (47%), Gaps = 3/148 (2%)
Query: 77 LLSLATIKVLDLHDNQLTALPD-DLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVK 135
+L + +K L L NQ+ D G L L++L+++ N L LP I L L+ LNV
Sbjct: 160 ILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVS 219
Query: 136 DNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGA 195
N + +P + +L ++R L N I+ P L + LE+LSL + + + P +
Sbjct: 220 HNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSL 279
Query: 196 GTAAILQFLCKESGLEYYPPSQYLLPIL 223
T +L + + L +P + LP L
Sbjct: 280 KTLRVLNL--EYNQLTTFPKALCFLPKL 305
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/148 (29%), Positives = 76/148 (51%), Gaps = 6/148 (4%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
IL++S +S IP + Q L + N++ + L L +++L L N+
Sbjct: 215 ILNVSHNHISHIPKEISQLGNIRQ---LFFYNNYIENF---PSDLECLGNLEILSLGKNK 268
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSL 152
L +PD L L L+VLN+E NQL P+++ L +L +L++ N + LP + EL++L
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNL 328
Query: 153 RTLNISGNEIQRLPQMLAHVRTLEMLSL 180
TL + N++ L + + ++ L L
Sbjct: 329 ETLLMDHNKLTFLAVEIFQLLKIKELQL 356
Score = 60.5 bits (145), Expect = 5e-09
Identities = 40/160 (25%), Positives = 84/160 (52%), Gaps = 5/160 (3%)
Query: 36 ISKCELS--EIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
I K ELS +I + C + L V+ N+++ + P S + L+L +N+L
Sbjct: 466 IIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI-PVDISFSK--QLLHLELSENKL 522
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+ L L+ L++ +NQ+ ++P SI N+ L L + NK + P + L +L+
Sbjct: 523 LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQ 582
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
L++S N++Q++ + +++ ++ L+ ++ ++ P E+C
Sbjct: 583 VLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
Score = 57.4 bits (137), Expect = 5e-08
Identities = 37/152 (24%), Positives = 78/152 (51%), Gaps = 3/152 (1%)
Query: 42 SEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLG 101
+++ F A ++L+ K L + N L + K + + +++L L N L +P+ +
Sbjct: 336 NKLTFLAVEIFQLLKIKELQLADNKLEVISHK---IENFRELRILILDKNLLKNIPEKIS 392
Query: 102 QLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNE 161
L+ L++ N+L +LP+ I L L+ L+V N + ++ D + L ++ +L SGN
Sbjct: 393 CCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNI 452
Query: 162 IQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
I +P + + + + + L + ++Y P +C
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484
Score = 56.6 bits (135), Expect = 8e-08
Identities = 37/132 (28%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 55 LQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERN 114
L K + + T +L S LPK + L ++ L + N+LT L ++ QL ++ L + N
Sbjct: 302 LPKLISLDLTGNLISSLPKE--IRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADN 359
Query: 115 QLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
+L + I N +L+ L + N LK +P+ + L L++S N++ LP+ + +
Sbjct: 360 KLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNN 419
Query: 175 LEMLSLDASAMV 186
L L ++ + MV
Sbjct: 420 LRKLHVNRNNMV 431
Score = 53.1 bits (126), Expect = 9e-07
Identities = 36/136 (26%), Positives = 72/136 (52%), Gaps = 5/136 (3%)
Query: 58 KVLIVHTNHLTSLLPK-SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQL 116
++LI+ N L ++ K SC A ++ L L DN+LT LP + +L L+ L+V RN +
Sbjct: 375 RILILDKNLLKNIPEKISCC----AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNM 430
Query: 117 MQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLE 176
+++ I +L + +L N + ++P + + + + +S N+I P L + +L
Sbjct: 431 VKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLY 490
Query: 177 MLSLDASAMVYPPREV 192
LS++ + + P ++
Sbjct: 491 YLSVNGNYISEIPVDI 506
Score = 44.7 bits (104), Expect = 3e-04
Identities = 37/135 (27%), Positives = 65/135 (48%), Gaps = 6/135 (4%)
Query: 21 QMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSL 80
++C + +I I +L+ +P G + + Q K L + N + + P++ L
Sbjct: 620 ELCQLQSLEQLNISQIKGRKLTRLP-GELSN--MTQLKELDISNNAIREI-PRNIG--EL 673
Query: 81 ATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLK 140
+ L ++NQ++ LP L L LQ LN+ N L LP +I N+ L+ +N DN L
Sbjct: 674 RNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLL 733
Query: 141 ELPDTVGELRSLRTL 155
P + + + L T+
Sbjct: 734 RPPVEICKGKQLYTI 748
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 87.4 bits (215), Expect = 4e-17
Identities = 54/184 (29%), Positives = 100/184 (54%), Gaps = 6/184 (3%)
Query: 21 QMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSL 80
Q+C K ++L + ++ ++P + K+ K+L + N S + SL SL
Sbjct: 321 QICALKNL---EVLGLDDNKIGQLPSELGSLSKL---KILGLTGNEFLSFPEEVLSLASL 374
Query: 81 ATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLK 140
+ + +LT +P+ + +L +L+ L +E N L LP S+G++ L+ L+ + N LK
Sbjct: 375 EKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLK 434
Query: 141 ELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAI 200
+LPD + + ++L+ L + N + LP+ L + L++L+L + M PP+EVC G AI
Sbjct: 435 QLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAI 494
Query: 201 LQFL 204
++L
Sbjct: 495 WKYL 498
Score = 74.7 bits (182), Expect = 3e-13
Identities = 34/104 (32%), Positives = 64/104 (61%)
Query: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
L L T++++DL +N++ A+P+++G LT LQ + N L LP S+ +QL L++
Sbjct: 184 LCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSH 243
Query: 137 NKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
N L +P + ELR + + +SGN ++++P+++ +L +L L
Sbjct: 244 NLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYL 287
Score = 68.2 bits (165), Expect = 3e-11
Identities = 44/160 (27%), Positives = 82/160 (51%), Gaps = 5/160 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
L + + +L EIP F L+ +L + NHL LPK +++ ++ + L NQ
Sbjct: 123 LRLYQTDLKEIPVVIFKNLHHLE--LLGLTGNHL-KCLPKE--IVNQTKLREIYLKRNQF 177
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
P +L L L++++++ N++ +P IG+LT LQ + N L LP ++ + L
Sbjct: 178 EVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLS 237
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
L++S N + +P+ A +R + + L + + PR +C
Sbjct: 238 VLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
Score = 67.8 bits (164), Expect = 3e-11
Identities = 42/141 (29%), Positives = 75/141 (53%), Gaps = 6/141 (4%)
Query: 58 KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
+ L + NHL + C+L +L +VL L DN++ LP +LG L+ L++L + N+ +
Sbjct: 306 RFLDLSQNHLHHCPLQICALKNL---EVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFL 362
Query: 118 QLPRSIGNLTQLQTLNVKDN---KLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
P + +L L+ L + + KL +P+ + +L+SL+ L I N ++ LP L +
Sbjct: 363 SFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPN 422
Query: 175 LEMLSLDASAMVYPPREVCGA 195
LE+L + + P +C A
Sbjct: 423 LEVLDCRHNLLKQLPDAICQA 443
Score = 58.9 bits (141), Expect = 2e-08
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 11/195 (5%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
+LD+S L IP +FA + + + + + N L + C SL +L L +
Sbjct: 238 VLDLSHNLLHSIP-KSFAELRKMTE--IGLSGNRLEKVPRLICRWTSL---HLLYLGNTG 291
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSL 152
L L L L+ L++ +N L P I L L+ L + DNK+ +LP +G L L
Sbjct: 292 LHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKL 351
Query: 153 RTLNISGNEIQRLPQMLAHVRTLEMLSL---DASAMVYPPREVCGAGTAAILQFLCKESG 209
+ L ++GNE P+ + + +LE L + + Y P + ++ + + +
Sbjct: 352 KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHI--RKLQSLKELYIENNH 409
Query: 210 LEYYPPSQYLLPILE 224
LEY P S +P LE
Sbjct: 410 LEYLPVSLGSMPNLE 424
Score = 55.8 bits (133), Expect = 1e-07
Identities = 46/170 (27%), Positives = 80/170 (47%), Gaps = 6/170 (3%)
Query: 32 DILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDN 91
+I+D+ + ++ IP LQK + +N+L L SL + + VLDL N
Sbjct: 191 EIIDLDENKIGAIP-EEIGHLTGLQK--FYMASNNLPVL---PASLCQCSQLSVLDLSHN 244
Query: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
L ++P +L + + + N+L ++PR I T L L + + L L + L +
Sbjct: 245 LLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVN 304
Query: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAIL 201
LR L++S N + P + ++ LE+L LD + + P E+ IL
Sbjct: 305 LRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKIL 354
Score = 50.4 bits (119), Expect = 6e-06
Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 27/164 (16%)
Query: 86 LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT 145
+D + LTA+P ++ T L+ +++E NQ+ ++P+ I L ++ L + N L+ L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 146 VGELRSLRTLNISGN------------------------EIQRLPQML-AHVRTLEMLSL 180
+G L SL +L++S N +++ +P ++ ++ LE+L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 181 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILE 224
+ + P+E+ + + K + E +P +L LE
Sbjct: 150 TGNHLKCLPKEI--VNQTKLREIYLKRNQFEVFPQELCVLYTLE 191
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/123 (23%), Positives = 63/123 (51%), Gaps = 1/123 (0%)
Query: 80 LATIKVLDLHDNQLTALPDDLGQ-LTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNK 138
L ++ L L+ L +P + + L L++L + N L LP+ I N T+L+ + +K N+
Sbjct: 117 LHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQ 176
Query: 139 LKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTA 198
+ P + L +L +++ N+I +P+ + H+ L+ + ++ + P +C
Sbjct: 177 FEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
Query: 199 AIL 201
++L
Sbjct: 237 SVL 239
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 86.3 bits (212), Expect = 9e-17
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 61 IVHTNHL----TSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQL 116
+ H HL SL +L + + L L N L+ LP+ LG L AL L V N+L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 117 MQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLE 176
LP ++G L+ LQ L++ N L LP +G L SL LN++ N +Q LP LA +R+L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 177 MLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPD 236
+L L ++ + P ++ A + + +++ L PP P + G SPD
Sbjct: 244 LLVLHSNLLASVPADL--ARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPD 301
Query: 237 GPT 239
P+
Sbjct: 302 APS 304
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 9/153 (5%)
Query: 71 LPKSCSLLSLATIKVLDLHDN-------QLTALPDDLGQLTALQVLNVERNQLMQLPRSI 123
LP+S S L +K D LT LP L L L L++ N L LP +
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 124 GNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDAS 183
+ L L + N L ELP+ +G L +L L ++ N +Q LP L + TL+ L L +
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Query: 184 AMVYPPREVCGAGTAAILQFLCKESGLEYYPPS 216
+ P E+ G G ++L+ + L+ P S
Sbjct: 205 LLDTLPPEIGGLG--SLLELNLASNRLQSLPAS 235
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 86.3 bits (212), Expect = 9e-17
Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 61 IVHTNHL----TSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQL 116
+ H HL SL +L + + L L N L+ LP+ LG L AL L V N+L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 117 MQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLE 176
LP ++G L+ LQ L++ N L LP +G L SL LN++ N +Q LP LA +R+L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 177 MLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPD 236
+L L ++ + P ++ A + + +++ L PP P + G SPD
Sbjct: 244 LLVLHSNLLASVPADL--ARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPD 301
Query: 237 GPT 239
P+
Sbjct: 302 APS 304
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 9/153 (5%)
Query: 71 LPKSCSLLSLATIKVLDLHDN-------QLTALPDDLGQLTALQVLNVERNQLMQLPRSI 123
LP+S S L +K D LT LP L L L L++ N L LP +
Sbjct: 85 LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
Query: 124 GNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDAS 183
+ L L + N L ELP+ +G L +L L ++ N +Q LP L + TL+ L L +
Sbjct: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Query: 184 AMVYPPREVCGAGTAAILQFLCKESGLEYYPPS 216
+ P E+ G G ++L+ + L+ P S
Sbjct: 205 LLDTLPPEIGGLG--SLLELNLASNRLQSLPAS 235
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 86.3 bits (212), Expect = 9e-17
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 14 ARKRLEYQMCLAKEAGADDIL--DISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLL 71
ARK E+ A D + D+SK L E+P C + ++L ++ N + ++
Sbjct: 80 ARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPM---ELCHFVSLEILNLYHNCIR-VI 135
Query: 72 PKSCSLLSLAT--------------------IKVLDLHDNQLTALPDDLGQLTALQVLNV 111
P++ L + T +KVL +N+L +LP+++GQL L L+V
Sbjct: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDV 195
Query: 112 ERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAH 171
N++ LP+ IG L L+ LNV+ N LK LP + +L L + S N++ +P
Sbjct: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFRE 254
Query: 172 VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYL----LPILEQDG 227
++ L++L L+ + + PP ++C G I ++L ++ S YL P L Q
Sbjct: 255 MKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHV 314
Query: 228 IENSRDS-----PDGPTDRFSREELEWQNRFS---DYEKRKEQKMLEKLEFERRLELGQR 279
+ +DS D R S E ++ S E++ + K + RL +
Sbjct: 315 EDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKG 374
Query: 280 EHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE-RQRLQEQLKQTEQNISSR 338
E Q Q S + + +E ++ H +N + R E+L + E+++ +
Sbjct: 375 EFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIEEDVHWQ 434
Query: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETES--LRRRDVASAMQQMLTES 396
+ ++ ++ Q +++ L ++ ++ + TE L + SA L +S
Sbjct: 435 TEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALELQDS 494
Query: 397 CKNRLIQM 404
N IQ+
Sbjct: 495 ALNGQIQL 502
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 83.2 bits (204), Expect = 8e-16
Identities = 52/152 (34%), Positives = 79/152 (51%), Gaps = 2/152 (1%)
Query: 88 LHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVG 147
L N L+ LP+ LG L AL L V N+L LP ++G L+ LQ L++ N L LP +G
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
Query: 148 ELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKE 207
L SL LN++ N +Q LP LA +R+L +L L ++ + P ++ A + + ++
Sbjct: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADL--ARLPLLTRLDLRD 126
Query: 208 SGLEYYPPSQYLLPILEQDGIENSRDSPDGPT 239
+ L PP P + G SPD P+
Sbjct: 127 NQLRDLPPELLDAPFVRLQGNPLGEASPDAPS 158
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 2/132 (1%)
Query: 64 TNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSI 123
+++ S LP++ L T L + N+L LP LG L+ LQ L++ +N L LP I
Sbjct: 10 SHNCLSELPEALGALPALTF--LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 67
Query: 124 GNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDAS 183
G L L LN+ N+L+ LP ++ LRSLR L + N + +P LA + L L L +
Sbjct: 68 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN 127
Query: 184 AMVYPPREVCGA 195
+ P E+ A
Sbjct: 128 QLRDLPPELLDA 139
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/181 (29%), Positives = 90/181 (49%), Gaps = 8/181 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+ E E+P +Q + N+ +LP S L + + LD+ N++
Sbjct: 189 LDLGNNEFGELP----EVLDQIQNLRELWMDNNALQVLPGSIGKLKM--LVYLDMSKNRI 242
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+ D+ AL+ L + N L QLP SIG L +L TL V DN+L LP+T+G L L
Sbjct: 243 ETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYY 213
+ S NE++ LP + ++ +L L++D + + PRE+ ++ + + LE+
Sbjct: 303 EFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSL--RSNKLEFL 360
Query: 214 P 214
P
Sbjct: 361 P 361
Score = 79.7 bits (195), Expect = 9e-15
Identities = 40/105 (38%), Positives = 62/105 (59%)
Query: 88 LHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVG 147
L N L LPD +G L L L V+ NQL LP +IGNL+ L+ + N+L+ LP T+G
Sbjct: 260 LSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIG 319
Query: 148 ELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
L SLRTL + N + LP+ + + + ++SL ++ + + P E+
Sbjct: 320 YLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI 364
Score = 77.4 bits (189), Expect = 4e-14
Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 11/155 (7%)
Query: 34 LDISKCE------LSEIPFGAFATCKVLQKKV--LIVHTNHLTSLLPKSCSLLSLATIKV 85
+DIS CE LS L KK+ L V N LT +LP + LSL ++
Sbjct: 247 MDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSL--LEE 303
Query: 86 LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT 145
D N+L +LP +G L +L+ L V+ N L +LPR IG+ + ++++ NKL+ LP+
Sbjct: 304 FDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE 363
Query: 146 VGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
+G+++ LR LN+S N ++ LP ++ L L L
Sbjct: 364 IGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398
Score = 72.4 bits (176), Expect = 1e-12
Identities = 55/187 (29%), Positives = 94/187 (50%), Gaps = 8/187 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LDISK + E P CK L ++ N ++ L LL+L L L+D L
Sbjct: 97 LDISKNGVQEFPEN-IKCCKCLT--IIEASVNPISKLPDGFTQLLNLTQ---LYLNDAFL 150
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LP + G+L L++L + N L LP+S+ L QL+ L++ +N+ ELP+ + ++++LR
Sbjct: 151 EFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLR 210
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYY 213
L + N +Q LP + ++ L L + + + ++ +G A+ L + L+
Sbjct: 211 ELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDI--SGCEALEDLLLSSNMLQQL 268
Query: 214 PPSQYLL 220
P S LL
Sbjct: 269 PDSIGLL 275
Score = 71.6 bits (174), Expect = 2e-12
Identities = 96/406 (23%), Positives = 181/406 (44%), Gaps = 30/406 (7%)
Query: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
++++ ++L + NHL +L PKS + LA ++ LDL +N+ LP+ L Q+ L+ L ++
Sbjct: 159 RLVKLRILELRENHLKTL-PKS--MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMD 215
Query: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
N L LP SIG L L L++ N+++ + + +L L +S N +Q+LP + +
Sbjct: 216 NNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLL 275
Query: 173 RTLEMLSLDASAMVYPPREVCGAGTAAIL-QFLCKESGLEYYPPSQYLLPILEQDGIENS 231
+ L L +D + + P + G ++L +F C + LE P + L L ++ +
Sbjct: 276 KKLTTLKVDDNQLTMLPNTI---GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDEN 332
Query: 232 RDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQ 291
P+ P + S + + + S+ KLEF E+GQ + ++L S ++
Sbjct: 333 -FLPELPREIGSCKNVTVMSLRSN-----------KLEFLPE-EIGQMQKLRVLNLSDNR 379
Query: 292 KDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRI---QKLLQDNQR 348
+ + + + LS++Q Q E +T+Q + + Q+ D
Sbjct: 380 LKNLPFSFTKLKELAALWLSDNQSKALIPLQ--TEAHPETKQRVLTNYMFPQQPRGDEDF 437
Query: 349 QKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYES 408
Q S +L E + +Q M++ E + + A ++ + ++ R Q
Sbjct: 438 QSDSDSFNPTLWEE--QRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWER-GQRGITL 494
Query: 409 QRQNLVQQACSSMAEMDERFQQILSWQQMDQNK--AISQILQESAM 452
Q L C+ A D++ Q + Q Q IS + QE +M
Sbjct: 495 QPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSM 540
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 51/216 (23%)
Query: 23 CLAKEAGADDILDISKCELSEIPFGAFA-----------------------TCKVLQKKV 59
C E +LD S C L ++P F C+ L+K
Sbjct: 16 CFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRK-- 73
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHD-----------------------NQLTAL 96
L + N L++L ++ SL +K LD+ N ++ L
Sbjct: 74 LSIPDNDLSNL---PTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKL 130
Query: 97 PDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLN 156
PD QL L L + L LP + G L +L+ L +++N LK LP ++ +L L L+
Sbjct: 131 PDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLD 190
Query: 157 ISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
+ NE LP++L ++ L L +D +A+ P +
Sbjct: 191 LGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSI 226
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/181 (30%), Positives = 99/181 (54%), Gaps = 8/181 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ E+ EIP + + CK LQ V N LT L P+S L + L ++D L
Sbjct: 87 LDVSRNEIPEIP-ESISFCKALQ--VADFSGNPLTRL-PESFP--ELQNLTCLSVNDISL 140
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+LP+++G L L L + N L LP S+ L +L+ L++ +N++ LP+++G L L+
Sbjct: 141 QSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLK 200
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYY 213
L + GN++ LPQ + +++ L L + + + P E+ +G ++ + ++ LE
Sbjct: 201 DLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI--SGLTSLTDLVISQNLLETI 258
Query: 214 P 214
P
Sbjct: 259 P 259
Score = 82.0 bits (201), Expect = 2e-15
Identities = 55/181 (30%), Positives = 96/181 (53%), Gaps = 8/181 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+ E+ +P A +L K L + N L+ L P+ +L + LD+ +N+L
Sbjct: 179 LDLGNNEIYNLPESIGA---LLHLKDLWLDGNQLSEL-PQEIG--NLKNLLCLDVSENRL 232
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LP+++ LT+L L + +N L +P IG L +L L V N+L +LP+ VGE SL
Sbjct: 233 ERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT 292
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYY 213
L ++ N++ LP+ + ++ L L+ D + +V P+E+ G ++ F +++ L
Sbjct: 293 ELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI--GGCCSLTVFCVRDNRLTRI 350
Query: 214 P 214
P
Sbjct: 351 P 351
Score = 79.3 bits (194), Expect = 1e-14
Identities = 48/138 (34%), Positives = 80/138 (57%), Gaps = 4/138 (2%)
Query: 66 HLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGN 125
+L + LP S L L ++ LDL +N++ LP+ +G L L+ L ++ NQL +LP+ IGN
Sbjct: 161 NLLTYLPDS--LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGN 218
Query: 126 LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
L L L+V +N+L+ LP+ + L SL L IS N ++ +P + ++ L +L +D + +
Sbjct: 219 LKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRL 278
Query: 186 VYPPREV--CGAGTAAIL 201
P V C + T +L
Sbjct: 279 TQLPEAVGECESLTELVL 296
Score = 77.4 bits (189), Expect = 4e-14
Identities = 84/327 (25%), Positives = 150/327 (45%), Gaps = 26/327 (7%)
Query: 66 HLTSLLPKSCSLLSLA--------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
H+ S+ + CSL+ + +++ L L NQL LP+ QL L+ L + N++
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
Query: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
+LP I N QL L+V N++ E+P+++ ++L+ + SGN + RLP+ ++ L
Sbjct: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
Query: 178 LSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSR--DSP 235
LS++ ++ P + A L+ +E+ L Y P S L LE+ + N+ + P
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLEL--RENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
Query: 236 DGPTDRFSREELEWQNRFSDYEKRKEQKMLEKL----EFERRLELGQREHTQLLQQSSSQ 291
+ ++L W + E +E L+ L E RLE E + L +
Sbjct: 191 ESIGALLHLKDL-WLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLV 249
Query: 292 -KDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQ--R 348
+L+T+ + +L++ L ++ RL QL + S + +L +NQ
Sbjct: 250 ISQNLLETIPDGIGKLKK-----LSILKVDQNRL-TQLPEAVGECESLTELVLTENQLLT 303
Query: 349 QKKSSEILKSLENERIRMEQLMSITQE 375
KS LK L N +L+S+ +E
Sbjct: 304 LPKSIGKLKKLSNLNADRNKLVSLPKE 330
Score = 71.6 bits (174), Expect = 2e-12
Identities = 45/156 (28%), Positives = 76/156 (48%), Gaps = 6/156 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ L +P L +V + +L +P L + +L + N+L
Sbjct: 225 LDVSENRLERLP----EEISGLTSLTDLVISQNLLETIPDGIG--KLKKLSILKVDQNRL 278
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
T LP+ +G+ +L L + NQL+ LP+SIG L +L LN NKL LP +G SL
Sbjct: 279 TQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLT 338
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPP 189
+ N + R+P ++ L +L + + +++ P
Sbjct: 339 VFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/140 (34%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
L IS+ L IP G K+ + +L V N LT L P++ ++ L L +NQL
Sbjct: 248 LVISQNLLETIPDGIG---KLKKLSILKVDQNRLTQL-PEAVG--ECESLTELVLTENQL 301
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LP +G+L L LN +RN+L+ LP+ IG L V+DN+L +P V + L
Sbjct: 302 LTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELH 361
Query: 154 TLNISGNEIQRLPQMLAHVR 173
L+++GN + LP L ++
Sbjct: 362 VLDVAGNRLLHLPLSLTALK 381
Score = 69.3 bits (168), Expect = 1e-11
Identities = 40/131 (30%), Positives = 70/131 (53%), Gaps = 2/131 (1%)
Query: 71 LPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQ 130
LP+ S L ++ L + N L +PD +G+L L +L V++N+L QLP ++G L
Sbjct: 235 LPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT 292
Query: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
L + +N+L LP ++G+L+ L LN N++ LP+ + +L + + + + P
Sbjct: 293 ELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPA 352
Query: 191 EVCGAGTAAIL 201
EV A +L
Sbjct: 353 EVSQATELHVL 363
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/113 (37%), Positives = 74/113 (65%), Gaps = 1/113 (0%)
Query: 81 ATIKVLDLHDNQLTALPDDL-GQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKL 139
+ ++ +DL +N++ +LP L G+ T L+ L++ N+L LP I NL +L+TL++ +N L
Sbjct: 38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHL 97
Query: 140 KELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
+ELP T G+L +L+TL++SGN++ LP L +R L+++ L + + P V
Sbjct: 98 RELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
Score = 73.2 bits (178), Expect = 8e-13
Identities = 38/120 (31%), Positives = 71/120 (59%), Gaps = 2/120 (1%)
Query: 58 KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
+ + + N + SL P +L +K L L++N+LT LPD++ L L+ L++ N L
Sbjct: 41 RTIDLSNNKIESLPPLLIGKFTL--LKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
Query: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
+LP + G L+ L+TL++ N+L LP + LR L +++S N+I+ +P + ++ +E+
Sbjct: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL 158
Score = 68.2 bits (165), Expect = 3e-11
Identities = 38/111 (34%), Positives = 64/111 (57%), Gaps = 2/111 (1%)
Query: 85 VLDLHDNQLTALPDDLGQLTA-LQVLNVERNQLMQLPRS-IGNLTQLQTLNVKDNKLKEL 142
V L D LT P DL +LT+ L+ +++ N++ LP IG T L++L++ +NKL L
Sbjct: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
Query: 143 PDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
PD + L+ L TL+++ N ++ LP + L+ LSL + + P ++C
Sbjct: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLC 128
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/151 (29%), Positives = 81/151 (53%), Gaps = 15/151 (9%)
Query: 32 DILDISKCELSEIP--FGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
+ L ++ L E+P FG + K L + N L +L P+ CSL L V+DL
Sbjct: 88 ETLSLNNNHLRELPSTFGQLSALKTLS-----LSGNQLGALPPQLCSLRHL---DVMDLS 139
Query: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDN--KLKELPDTVG 147
NQ+ ++PD +G+L ++ LN+ +NQ+ Q+ I +L+ L +++N +L LP ++
Sbjct: 140 KNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
Query: 148 ELRSLRTLNISGN--EIQRLPQMLAHVRTLE 176
+ L + GN EI++L ++ + + +E
Sbjct: 199 SDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 80.1 bits (196), Expect = 7e-15
Identities = 53/158 (33%), Positives = 86/158 (54%), Gaps = 5/158 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S L+ + GA + + + L + N L +L L +LA ++ LD+ N+L
Sbjct: 116 LDVSHNRLTAL--GAEVVSALRELRKLNLSHNQLPAL---PAQLGALAHLEELDVSFNRL 170
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LPD L L+ L+ L+V+ NQL PR + L L+ L+V N+L+ LP+ + LR+L+
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALK 230
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPRE 191
L +SG E+ LP + +LE L LD + + P +
Sbjct: 231 ILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQ 268
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/172 (31%), Positives = 87/172 (50%), Gaps = 8/172 (4%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPK-SCSLLSLATIKVLDLHDN 91
IL +S EL +P G C++ + L++ N L +L + SC L +K+L+L N
Sbjct: 231 ILWLSGAELGTLPAGF---CELASLESLMLDNNGLQALPAQFSC----LQRLKMLNLSSN 283
Query: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
P L L L+ L + RNQL +P I L +L TL + +N+++ LPD++ EL
Sbjct: 284 LFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTG 343
Query: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQF 203
L L + GN+I LP + + + + + ++ PP EVC G I +
Sbjct: 344 LEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAY 395
Score = 77.0 bits (188), Expect = 6e-14
Identities = 60/216 (27%), Positives = 102/216 (47%), Gaps = 26/216 (12%)
Query: 21 QMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSL--- 77
Q+ L G + L++ L E+P G + L +VL++ N L P L
Sbjct: 55 QLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSL--RVLVLRRNRFARLPPAVAELGHH 112
Query: 78 -------------------LSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
+L ++ L+L NQL ALP LG L L+ L+V N+L
Sbjct: 113 LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
Query: 119 LPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEML 178
LP S+ L++L+TL+V N+L P + +L +L L++S N ++ LP+ ++ +R L++L
Sbjct: 173 LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKIL 232
Query: 179 SLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYP 214
L + + P C A++ + +GL+ P
Sbjct: 233 WLSGAELGTLPAGFC--ELASLESLMLDNNGLQALP 266
Score = 72.8 bits (177), Expect = 1e-12
Identities = 58/196 (29%), Positives = 94/196 (47%), Gaps = 13/196 (6%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S L+ +P ++ + L V N LT+ P+ LL L ++ LD+ N+L
Sbjct: 163 LDVSFNRLAHLPDSLSCLSRL---RTLDVDHNQLTAF-PRQ--LLQLVALEELDVSSNRL 216
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LP+D+ L AL++L + +L LP L L++L + +N L+ LP L+ L+
Sbjct: 217 RGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLK 276
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYY 213
LN+S N + P L + LE L L + + P + G G +L + + Y
Sbjct: 277 MLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLG--RLLTLWLDNNRIRYL 334
Query: 214 PPSQYLLPILEQDGIE 229
P S I+E G+E
Sbjct: 335 PDS-----IVELTGLE 345
Score = 70.5 bits (171), Expect = 5e-12
Identities = 56/152 (36%), Positives = 80/152 (52%), Gaps = 10/152 (6%)
Query: 34 LDISKCELSEIP--FGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDN 91
L++S +L +P GA A + L V N L L P S S LS ++ LD+ N
Sbjct: 140 LNLSHNQLPALPAQLGALAHLEELD-----VSFNRLAHL-PDSLSCLS--RLRTLDVDHN 191
Query: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
QLTA P L QL AL+ L+V N+L LP I L L+ L + +L LP EL S
Sbjct: 192 QLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELAS 251
Query: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDAS 183
L +L + N +Q LP + ++ L+ML+L ++
Sbjct: 252 LESLMLDNNGLQALPAQFSCLQRLKMLNLSSN 283
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 80.1 bits (196), Expect = 7e-15
Identities = 48/120 (40%), Positives = 71/120 (59%), Gaps = 2/120 (1%)
Query: 66 HLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGN 125
+L LP S S L ++ LDL N L LPD LG L L+ L ++RNQL LP +GN
Sbjct: 161 NLLKSLPASLSFL--VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
Query: 126 LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
L +L L+V +N+L+ELP +G L L L +S N ++RLP + ++ L +L +D + +
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/161 (35%), Positives = 85/161 (52%), Gaps = 6/161 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ ++ EIP + CK L+ + N L+ L L SLA L L+D L
Sbjct: 87 LDVSRNDIPEIP-ESIKFCKALE--IADFSGNPLSRLPDGFTQLRSLAH---LALNDVSL 140
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
ALP D+G L L L + N L LP S+ L +L+ L++ N L+ LPDT+G L +LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
L + N++ LP L ++R L L + + + P E+ G
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Score = 73.6 bits (179), Expect = 6e-13
Identities = 48/151 (31%), Positives = 81/151 (53%), Gaps = 5/151 (3%)
Query: 65 NHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIG 124
N L++L P+ L +L + LD+ +N+L LP +LG L L L + +N L +LP IG
Sbjct: 207 NQLSALPPE---LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263
Query: 125 NLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASA 184
L QL L V N+L E+ + +G+ +L L ++ N + LP+ L + L L++D +
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
Query: 185 MVYPPREVCGAGTAAILQFLCKESGLEYYPP 215
+ P E+ G ++L +++ L PP
Sbjct: 324 LEALPPEIGGCVALSVLSL--RDNRLAVLPP 352
Score = 72.0 bits (175), Expect = 2e-12
Identities = 38/87 (43%), Positives = 51/87 (58%)
Query: 86 LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT 145
L L +N L ALP LG+LT L LNV+RN L LP IG L L+++DN+L LP
Sbjct: 294 LILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPE 353
Query: 146 VGELRSLRTLNISGNEIQRLPQMLAHV 172
+ L L+++GN +Q LP L H+
Sbjct: 354 LAHTTELHVLDVAGNRLQSLPFALTHL 380
Score = 69.7 bits (169), Expect = 9e-12
Identities = 39/117 (33%), Positives = 63/117 (53%)
Query: 76 SLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVK 135
+L +L ++ L L NQL+ALP +LG L L L+V N+L +LP +G L L L +
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 136 DNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
N L+ LPD +G+L+ L L + N + + + + L L L + ++ PR +
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/168 (28%), Positives = 84/168 (50%), Gaps = 10/168 (5%)
Query: 66 HLTSLLPKSCSLLSLA--------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
H+ S+ + CSL ++ +++ L L NQL LP +L L+ L + N++
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
+LP + N QL L+V N + E+P+++ ++L + SGN + RLP +R+L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 178 LSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQ 225
L+L+ ++ P +V L+ +E+ L+ P S L LEQ
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLEL--RENLLKSLPASLSFLVKLEQ 178
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/147 (33%), Positives = 74/147 (50%), Gaps = 6/147 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ L E+P A VL +L+ + +L LP L + +L + N+L
Sbjct: 225 LDVSENRLEELP--AELGGLVLLTDLLL--SQNLLRRLPDGIG--QLKQLSILKVDQNRL 278
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+ + +G L L + N LM LPRS+G LT+L LNV N L+ LP +G +L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSL 180
L++ N + LP LAH L +L +
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDV 365
Score = 68.2 bits (165), Expect = 3e-11
Identities = 46/131 (35%), Positives = 66/131 (50%), Gaps = 4/131 (3%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQL 119
L V N L L L L + L L N L LPD +GQL L +L V++N+L ++
Sbjct: 225 LDVSENRLEEL---PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Query: 120 PRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLS 179
+IG+ L L + +N L LP ++G+L L LN+ N ++ LP + L +LS
Sbjct: 282 TEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 180 L-DASAMVYPP 189
L D V PP
Sbjct: 342 LRDNRLAVLPP 352
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/279 (26%), Positives = 121/279 (43%), Gaps = 34/279 (12%)
Query: 39 CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPD 98
CE++E A C+ L + +L T +L LP+S L+ T L++ N L ALP
Sbjct: 279 CEVTE----AIGDCENLSELIL---TENLLMALPRSLGKLTKLTN--LNVDRNHLEALPP 329
Query: 99 DLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNIS 158
++G AL VL++ N+L LP + + T+L L+V N+L+ LP + L +L+ L ++
Sbjct: 330 EIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLA 388
Query: 159 GNEIQRLPQMLAH--VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPS 216
N+ Q + + RT E + PP + AG L ++ PPS
Sbjct: 389 ENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDA-----PPS 443
Query: 217 QYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLEL 276
+ + ++P G D EE + R ++R E +R +E
Sbjct: 444 RV--------SVIQFLEAPIGDED---AEEAAAEKR--GLQRRATPHPSELKVMKRSIE- 489
Query: 277 GQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQR 315
G+R Q S L +E++ E GLSE R
Sbjct: 490 GRRSEACPCQPDSGSP---LPAEEEKRLSAESGLSEDSR 525
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 80.1 bits (196), Expect = 7e-15
Identities = 48/120 (40%), Positives = 71/120 (59%), Gaps = 2/120 (1%)
Query: 66 HLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGN 125
+L LP S S L ++ LDL N L LPD LG L L+ L ++RNQL LP +GN
Sbjct: 161 NLLKSLPASLSFL--VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
Query: 126 LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
L +L L+V +N+L+ELP +G L L L +S N ++RLP + ++ L +L +D + +
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/161 (35%), Positives = 85/161 (52%), Gaps = 6/161 (3%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ ++ EIP + CK L+ + N L+ L L SLA L L+D L
Sbjct: 87 LDVSRNDIPEIP-ESIKFCKALE--IADFSGNPLSRLPDGFTQLRSLAH---LALNDVSL 140
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
ALP D+G L L L + N L LP S+ L +L+ L++ N L+ LPDT+G L +LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
L + N++ LP L ++R L L + + + P E+ G
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Score = 73.6 bits (179), Expect = 6e-13
Identities = 48/151 (31%), Positives = 81/151 (53%), Gaps = 5/151 (3%)
Query: 65 NHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIG 124
N L++L P+ L +L + LD+ +N+L LP +LG L L L + +N L +LP IG
Sbjct: 207 NQLSALPPE---LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263
Query: 125 NLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASA 184
L QL L V N+L E+ + +G+ +L L ++ N + LP+ L + L L++D +
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
Query: 185 MVYPPREVCGAGTAAILQFLCKESGLEYYPP 215
+ P E+ G ++L +++ L PP
Sbjct: 324 LEALPPEIGGCVALSVLSL--RDNRLAVLPP 352
Score = 72.0 bits (175), Expect = 2e-12
Identities = 38/87 (43%), Positives = 51/87 (58%)
Query: 86 LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT 145
L L +N L ALP LG+LT L LNV+RN L LP IG L L+++DN+L LP
Sbjct: 294 LILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPE 353
Query: 146 VGELRSLRTLNISGNEIQRLPQMLAHV 172
+ L L+++GN +Q LP L H+
Sbjct: 354 LAHTTELHVLDVAGNRLQSLPFALTHL 380
Score = 69.7 bits (169), Expect = 9e-12
Identities = 39/117 (33%), Positives = 63/117 (53%)
Query: 76 SLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVK 135
+L +L ++ L L NQL+ALP +LG L L L+V N+L +LP +G L L L +
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 136 DNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
N L+ LPD +G+L+ L L + N + + + + L L L + ++ PR +
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/168 (28%), Positives = 84/168 (50%), Gaps = 10/168 (5%)
Query: 66 HLTSLLPKSCSLLSLA--------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
H+ S+ + CSL ++ +++ L L NQL LP +L L+ L + N++
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
+LP + N QL L+V N + E+P+++ ++L + SGN + RLP +R+L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 178 LSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQ 225
L+L+ ++ P +V L+ +E+ L+ P S L LEQ
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLEL--RENLLKSLPASLSFLVKLEQ 178
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/147 (33%), Positives = 74/147 (50%), Gaps = 6/147 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S+ L E+P A VL +L+ + +L LP L + +L + N+L
Sbjct: 225 LDVSENRLEELP--AELGGLVLLTDLLL--SQNLLRRLPDGIG--QLKQLSILKVDQNRL 278
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
+ + +G L L + N LM LPRS+G LT+L LNV N L+ LP +G +L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSL 180
L++ N + LP LAH L +L +
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDV 365
Score = 68.2 bits (165), Expect = 3e-11
Identities = 46/131 (35%), Positives = 66/131 (50%), Gaps = 4/131 (3%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQL 119
L V N L L L L + L L N L LPD +GQL L +L V++N+L ++
Sbjct: 225 LDVSENRLEEL---PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Query: 120 PRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLS 179
+IG+ L L + +N L LP ++G+L L LN+ N ++ LP + L +LS
Sbjct: 282 TEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 180 L-DASAMVYPP 189
L D V PP
Sbjct: 342 LRDNRLAVLPP 352
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/279 (26%), Positives = 121/279 (43%), Gaps = 34/279 (12%)
Query: 39 CELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPD 98
CE++E A C+ L + +L T +L LP+S L+ T L++ N L ALP
Sbjct: 279 CEVTE----AIGDCENLSELIL---TENLLMALPRSLGKLTKLTN--LNVDRNHLEALPP 329
Query: 99 DLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNIS 158
++G AL VL++ N+L LP + + T+L L+V N+L+ LP + L +L+ L ++
Sbjct: 330 EIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLA 388
Query: 159 GNEIQRLPQMLAH--VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPS 216
N+ Q + + RT E + PP + AG L ++ PPS
Sbjct: 389 ENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDA-----PPS 443
Query: 217 QYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLEL 276
+ + ++P G D EE + R ++R E +R +E
Sbjct: 444 RV--------SVIQFLEAPIGDED---AEEAAAEKR--GLQRRATPHPSELKVMKRSIE- 489
Query: 277 GQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQR 315
G+R Q S L +E++ E GLSE R
Sbjct: 490 GRRSEACPCQPDSGSP---LPAEEEKRLSAESGLSEDSR 525
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 80.1 bits (196), Expect = 7e-15
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 3/138 (2%)
Query: 58 KVLIVHTNHL--TSLLPKSCSLLSLA-TIKVLDLHDNQLTALPDDLGQLTALQVLNVERN 114
+ L+ N L S LPK + L +++VL+L N +P L +L ALQ L++ N
Sbjct: 94 RTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGN 153
Query: 115 QLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
QL +P I NL L+ L + N +KE+P +G L SL L + N+IQ +P L+ + +
Sbjct: 154 QLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS 213
Query: 175 LEMLSLDASAMVYPPREV 192
L LSL + + Y PRE+
Sbjct: 214 LRSLSLHNNLLTYLPREI 231
Score = 71.2 bits (173), Expect = 3e-12
Identities = 38/111 (34%), Positives = 67/111 (60%)
Query: 76 SLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVK 135
SLL L ++ L L NQL ++P ++ L +L+ L + N + ++P +GNL L L +
Sbjct: 138 SLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLC 197
Query: 136 DNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMV 186
DNK++ +P + +L SLR+L++ N + LP+ + ++ LE LSL + +V
Sbjct: 198 DNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLV 248
Score = 63.5 bits (153), Expect = 6e-10
Identities = 52/179 (29%), Positives = 93/179 (51%), Gaps = 12/179 (6%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQL--- 116
L++ N L SL P++ +++LD+ N LTAL +L L L+ L + N+L
Sbjct: 49 LLLPHNRLVSL-PRALGS-GFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGP 106
Query: 117 MQLPRSIGN---LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVR 173
LP+ + LQ LN+ N +E+P ++ ELR+L+TL++ GN++Q +P + +++
Sbjct: 107 SALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQ 166
Query: 174 TLEMLSLDASAMVYPPREVCGAGTAAILQFLCK-ESGLEYYPPSQYLLPILEQDGIENS 231
+LE L L + + P E+ G L +L ++ ++ PP L L + N+
Sbjct: 167 SLECLYLGGNFIKEIPPEL---GNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNN 222
Score = 44.3 bits (103), Expect = 4e-04
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 30/122 (24%)
Query: 101 GQLTALQVLNVERNQLMQLPRSIGN------------------------LTQLQTLNVKD 136
G AL L + N+L+ LPR++G+ L L+TL K+
Sbjct: 41 GAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKN 100
Query: 137 NKL---KELPDTVGE---LRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
N+L LP + + RSL+ LN+SGN Q +P L +R L+ LSL + + P
Sbjct: 101 NRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPA 160
Query: 191 EV 192
E+
Sbjct: 161 EI 162
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 79.7 bits (195), Expect = 9e-15
Identities = 101/409 (24%), Positives = 178/409 (43%), Gaps = 41/409 (10%)
Query: 205 CKESGLEYYPPSQYL----LPILEQDGIENSRDSPDGPTDRF--SREELEWQNRFSDYEK 258
CK E +P + L L L + G E + DR EE EW+ R +
Sbjct: 196 CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR--ETVL 253
Query: 259 RKEQKMLEKLEFERRLELGQRE------HTQLLQQSSSQKDEILQTVKEEQSRLEQGLSE 312
RKE++ L++ E +R+ EL + E Q L++ ++++ Q ++ EQ +L + E
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRRKQEE 312
Query: 313 HQRHLNAERQRLQEQLKQTEQNISSRI---------QKLLQDNQRQKKSSEILKSLENER 363
+R ER+ QE+ +Q E+ ++ Q+L ++ + +++ ++ + E ER
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 364 ----IRMEQLMSITQE--ETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQA 417
+R EQ + Q+ + LRR QQ+ E R Q+ E Q + ++
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 418 CSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKL 477
ER +Q L +Q ++ + + +E+ + Q+K+D + +KL
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKR-EEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 478 IETELLQLTQLELKRKSLDTESLQEMISEQRWAL---SSLLQQLLKEKQQ---REEELRE 531
E E + Q E + + L E QE EQR LQQ L+ +QQ +EE RE
Sbjct: 492 EEEE--RREQQERREQQLRRE--QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 532 ILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEE 580
L + E + QE + ++ LK +EE +++L EE
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Score = 79.0 bits (193), Expect = 1e-14
Identities = 78/359 (21%), Positives = 173/359 (48%), Gaps = 26/359 (7%)
Query: 223 LEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHT 282
LE+ + R + R RE+ Q R E+R+EQ+ + + ERR + +R
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQ---QLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 283 QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKL 342
QL ++ ++++ L+ +EE+ R +Q E + ++ R ++QL++ +Q R ++
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ---LRREQQ 394
Query: 343 LQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLI 402
L+ Q+ ++ ++ + +++R EQ + Q+ LRR +Q + + + +
Sbjct: 395 LRREQQLRREQQLRR---EQQLRREQQLRREQQ----LRREQEEERHEQKHEQERREQRL 447
Query: 403 QMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQV 462
+ E +R L ++ + E + R QQ+ Q+ ++ + ++ +E ++ Q+
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 463 KKDLMHRQIRSQIKLIETELLQ---LTQLELKRKSLD-TESLQEMISEQRWALSSLLQQL 518
+++ R+ + + E E LQ ++ +L+R+ + E L + E+R Q+L
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 519 LKEKQQREEELREILTELEAKSETRQENYWLIQYQRL---LNQKPLSLKLQEEGMERQL 574
+E+++R ++L L+ + E RQ+ Q +RL L ++ + QEE E++L
Sbjct: 568 KREQEERRDQL------LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Score = 70.5 bits (171), Expect = 5e-12
Identities = 97/389 (24%), Positives = 171/389 (43%), Gaps = 29/389 (7%)
Query: 202 QFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREE------LEWQNRFSD 255
+FL +E L Q L ++ E + DR REE E + +F +
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 256 YEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQK--DEILQTVKEEQSRL--EQGL- 310
E++ Q+ K E +L L +RE QL +Q +K +E Q ++E+ R EQ L
Sbjct: 1451 EEQQLRQERHRKFREEEQL-LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 311 -SEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRME-Q 368
E +R E Q+L Q +Q + + Q Q+ +Q++ K E E++R E +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQ-RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 369 LMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERF 428
++++E + R + +Q Q+ + +Q L Q+ E DE+
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE-DEQL 1627
Query: 429 QQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLI-ETELLQLTQ 487
Q QQ+ + + + L+E + Q++ D R+ R + +L+ E E QL +
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD-RDRKFREEEQLLQEGEEQQLRR 1686
Query: 488 LELKRKSLDTESLQEMISEQRWALSS---LLQQLLKEKQQREEELREILTELEAKSETRQ 544
E RK + E +R L L +Q L+ K + EE+LR+ E E + RQ
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ---ETEQEQLRRQ 1743
Query: 545 ENYWLIQYQRLLNQKPLSLKLQEEGMERQ 573
E +Y+++L ++ L + +E+ + RQ
Sbjct: 1744 E-----RYRKILEEEQLRPEREEQQLRRQ 1767
Score = 68.9 bits (167), Expect = 2e-11
Identities = 91/400 (22%), Positives = 181/400 (45%), Gaps = 49/400 (12%)
Query: 201 LQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRK 260
LQFL +E L+ +Q L E+DG++ ++ + R + +W+ + + KR+
Sbjct: 831 LQFLEEEEQLQRRERAQQLQE--EEDGLQEDQERR---RSQEQRRDQKWRWQLEEERKRR 885
Query: 261 EQKMLEKLEFERRLELGQREHTQLLQQSSS--QKDEILQTVKEEQSRL----EQGLSEHQ 314
+ K + +L R+ QLLQ+ Q++E + ++EQ R EQ E +
Sbjct: 886 RHTLYAKPALQEQL----RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 315 RHLNAERQRLQEQLKQTEQNISSRIQK----LLQDNQRQKKSSEILKSLENERIRMEQLM 370
+ L ER++ + Q ++ + ++Q+ LL + +++ E K E ++
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 371 SITQEETESLRRR----------DVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 420
+ +EE E RR+ ++ +Q+L E + R +Q E +RQ ++
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ---ERERQYREEE---- 1054
Query: 421 MAEMDERFQQILSWQQMDQNK--AISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLI 478
E+ + +Q+L ++ + + Q +E +Q+ + L+ + + RQ R + +
Sbjct: 1055 --ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER-QCR 1111
Query: 479 ETELLQLTQLELKRKSLDTESLQEMISEQR--WALSSLLQQLLK---EKQQREEELREIL 533
E E LQ + +L R+ + QE+ + R + +QLL+ EK++R+E R+
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 534 TELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQ 573
E E + E E L + Q Q+ +EE ++RQ
Sbjct: 1172 EEEELQQE---EEQLLREEQEKRRQERERQYREEEELQRQ 1208
Score = 67.4 bits (163), Expect = 4e-11
Identities = 87/375 (23%), Positives = 174/375 (46%), Gaps = 51/375 (13%)
Query: 239 TDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEIL-- 296
T+R +E + Q + E+R+E+ + KLE E R E +R QL ++ ++++ L
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWL--KLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 297 --------QTVK-EEQSRLEQ-----GLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKL 342
Q ++ E+Q R EQ L + + E++R +++LK+ ++ ++ K
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 343 LQDNQRQKKSSEILKSLENERIRMEQLMSITQEE--TESLRRRDVASAMQQML--TESCK 398
++ ++Q+ E + LE +R++ E++ + QEE + L+R + +Q L +E +
Sbjct: 582 EEERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 399 NRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFE 458
R Q Q++ Q+ E +ER +Q L ++ ++ + ++ +E Q+ A E
Sbjct: 641 ERRQQQLRREQQERREQRL--KREEEEERLEQRLK-REHEEERREQELAEEE--QEQARE 695
Query: 459 ALQVKKDLMHRQIRSQIKLIETELLQLTQLE--LKRKSLDTESLQEMISEQRWALSSLLQ 516
++ + Q+ S+ ++++ + + +R+ E + SE +W +
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-----E 750
Query: 517 QLLKEKQQREEELREILT---ELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQ 573
+ +QQ+EEE R T + E KSE + QRL + PL E ERQ
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGR--------QRLSARPPL-----REQRERQ 797
Query: 574 LVALLEELSAEHYLP 588
L A + + +LP
Sbjct: 798 LRAEERQQREQRFLP 812
Score = 67.0 bits (162), Expect = 6e-11
Identities = 84/399 (21%), Positives = 169/399 (42%), Gaps = 51/399 (12%)
Query: 248 EWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRL- 306
E +F + E R +++ + LE E+RL +RE L ++ + E Q +++++ R
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 307 ---EQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQ-KKSSEILKSLENE 362
EQ LS +R + Q + ++ E+ Q+L Q+ R+ ++ ++L+ E +
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 363 RIRMEQLMSITQEETESLRR--RDVASAMQQMLTESCKNRLI---QMAYESQRQNLVQQA 417
++ ++ EE + LRR RD Q++ ++ + + + Q + QRQ Q
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 418 CSSMAEMD-------ERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQ 470
+ + +R ++ +Q+ Q + Q+ ++ +K E +V++ R+
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 471 -IRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKE-----KQQ 524
+ + +L E Q + E RK + E L + EQ+ ++ L+E +Q+
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 525 REEELR-----------EILTELEAKSETRQEN-----------------YWLIQYQRLL 556
RE++LR ++L E E + RQE +Q ++ L
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 557 NQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRL 595
++ L K +EE RQ + E Y I +L
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Score = 65.1 bits (157), Expect = 2e-10
Identities = 84/369 (22%), Positives = 158/369 (42%), Gaps = 27/369 (7%)
Query: 229 ENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQS 288
E R + R RE+ E +++ E+ + Q+ L++ + ER + +RE + L+Q
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 289 SSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQR 348
++ + + EE+ R + SE Q +R Q+QL++ +Q R Q+L ++ +
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQ------EERRQQQLRREQQ--ERREQRLKREEEE 665
Query: 349 QKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQ-QMLTESCKNRLIQMAYE 407
++ + + E ER E + +EE E R R + + Q ES + Y
Sbjct: 666 ERLEQRLKREHEEERREQE----LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 408 SQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFE-ALQVKKDL 466
R+ Q+ E R + L WQ ++ +A Q +E + ++ + K +
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQ--EEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 467 MHRQIRSQIKLIETELLQLTQLELKRKS---LDTESLQEMISEQRWALSSLLQQLLKEKQ 523
+++ ++ L E QL E +++ L E +E QR LQ L +E+Q
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 524 QREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLV-----ALL 578
+ RE +L+ + + QE+ + Q + +L+EE R+ AL
Sbjct: 840 LQR---RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 579 EELSAEHYL 587
E+L E L
Sbjct: 897 EQLRKEQQL 905
Score = 65.1 bits (157), Expect = 2e-10
Identities = 66/311 (21%), Positives = 141/311 (45%), Gaps = 21/311 (6%)
Query: 248 EWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRL- 306
E +F + E R ++ + LE E++L QR+ L ++ ++ E Q ++++ R
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 307 --EQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQ--KLLQDNQ--RQKKSSEILKSLE 360
E+ L + + RQ + + EQ + + Q K ++D Q R+++ + L+
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 361 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQR-----QNLVQ 415
+ + R ++ + +EE + R+ +++ + R Q+ ++ R + L+Q
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 416 QACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQI 475
+ ER ++ +Q Q+ ++ +K E Q+++ + R+ R +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQ--------QLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 476 KLI-ETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILT 534
+L ETE QL + E RK L+ E L+ EQ+ ++ +E+Q R+E + L
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789
Query: 535 ELEAKSETRQE 545
E+ + R+E
Sbjct: 1790 SQESDRKFREE 1800
Score = 64.7 bits (156), Expect = 3e-10
Identities = 80/355 (22%), Positives = 153/355 (43%), Gaps = 41/355 (11%)
Query: 238 PTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQ----------REHTQLLQQ 287
P +F EE + + +++++K L++ + RR E GQ RE QL Q+
Sbjct: 1513 PERKFLEEEQQL------HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 288 ------SSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQK 341
S ++D + +++ R EQ + RQ Q+QL+Q ++
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 342 LLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAM---QQMLTESCK 398
LLQ+ + Q+ L E +R +E+ + ++E E R D +Q+L E +
Sbjct: 1627 LLQEREEQQ-----LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 399 NRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFE 458
+L + + + + QQ ER ++ L +Q + + + + +E + E
Sbjct: 1682 QQLRRQERDRKFREEEQQL-----RRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736
Query: 459 ALQVKKDLMHRQIRSQIKLI-ETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQ 517
Q+++ +R+I + +L E E QL + E RK + E L++ EQ+ L Q
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ-----LRSQ 1791
Query: 518 LLKEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMER 572
K + EE+LR+ E + + + R Y + Q L ++ L+ + + R
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Score = 64.3 bits (155), Expect = 4e-10
Identities = 77/358 (21%), Positives = 161/358 (44%), Gaps = 44/358 (12%)
Query: 244 REELEWQ----------NRFSDYEKRKEQKMLEKLEFERRL-------ELGQREHTQLLQ 286
RE+ E Q RF E+ KEQ+ ++ E E+ L +L +RE Q LQ
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 287 QSSSQKDEILQTVKEEQSRLEQGL-------SEHQRHLNAERQRLQEQLKQTEQNISSRI 339
+ E + + ++ R +Q + +RH + LQEQL++ +Q +
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 340 QKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRD-VASAMQQMLTESCK 398
++L ++ + +++ E + E ++ + +EE E RR++ + + +
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 399 NRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFE 458
+L+ E +R+ ++ E+ + +Q+L ++ + + QE Q +
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR------QEWERQYRKKD 1024
Query: 459 ALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQL 518
LQ +++ + R+ R + +L E E + EL+++ ++++ E+R + +Q
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEE------EQLLGEER---ETRRRQE 1075
Query: 519 LKEKQQREEELR---EILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQ 573
L+ + ++EEEL+ E L E + RQE + + L Q+ L L+EE +R+
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL-LREEREKRR 1132
Score = 60.1 bits (144), Expect = 7e-09
Identities = 76/346 (21%), Positives = 149/346 (43%), Gaps = 31/346 (8%)
Query: 255 DYEKRKEQKMLEKLEFERRLELGQR----EHTQLLQQSSSQKDEILQTVKEEQSRLEQGL 310
D EKR E L +RR E QR QL ++ ++ + Q + E + E+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 311 SEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQK-KSSEILKSLENERIRMEQL 369
+ +R +RQR E+L + Q R ++ ++ Q Q K E + + E++R +L
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 370 MSI---------------------TQEETESLRRRDVASAMQQMLTESCKNRLIQM-AYE 407
+ + +EE E +R V ++ L E R ++ E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 408 SQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLM 467
Q + L +Q + +E+ QQ L +Q + K + ++ ++ E + +++
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 468 HRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREE 527
+Q+R + + + L+ Q E +R + + +E E+R QQL +E+Q R E
Sbjct: 336 EQQLRREQEERREQQLRREQEEERR---EQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 528 ELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQ 573
+ +L + + R+E L + Q+L ++ L + +EE E++
Sbjct: 393 QQLRREQQLRREQQLRREQQ-LRREQQLRREQQLRREQEEERHEQK 437
Score = 60.1 bits (144), Expect = 7e-09
Identities = 89/388 (22%), Positives = 164/388 (42%), Gaps = 55/388 (14%)
Query: 244 REELEWQNRFSDYEKRKEQKMLEKLEFERRL---ELGQREHTQLLQQSSSQKDEILQTVK 300
R+E E Q R D +++E+++L + +RRL E RE +L Q+ E +T +
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 301 ----EEQSRLEQGLSEHQRHL---NAERQRLQEQLKQT--EQNISSRIQKLLQDNQRQKK 351
E Q R E+ L + + L E++R QE+ +Q E+ + ++LL++ + +++
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 352 SSEILKSLENERIRMEQLMSITQEETESLRRRDVASAM----------QQMLTESC---- 397
E+ + E ++ + +EE E RR+++ +Q+L E
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 398 --KNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKA 455
+ R + E QRQ Q+ + D+R W+ +N + +
Sbjct: 1193 QERERQYREEEELQRQKRKQR----YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 456 AFEAL--------QVKKDLMHRQIRSQIKLIETELLQLTQLEL---KRKSLDTESLQEMI 504
F L Q ++DL H Q + E E + Q + + + L+ E +E
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308
Query: 505 SEQRWAL--SSLLQQLLKEKQQREE------ELREILTELEAKSETRQENYWLIQYQRLL 556
R + LL++ +EK++R+E E ++L E E + RQE + + L
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 557 NQKPLSLKLQEE----GMERQLVALLEE 580
+Q+ L+EE ER+ L EE
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Score = 60.1 bits (144), Expect = 7e-09
Identities = 101/387 (26%), Positives = 175/387 (45%), Gaps = 58/387 (14%)
Query: 232 RDSPDGPTDRFSREELEWQNRFSDYEKRKEQKML--EKLEFERRLELGQ--REHTQLLQQ 287
RD ++ REE + R D + ++E+++L E+ E RR E + RE QLLQ+
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 288 SSSQ---KDEILQTVKEEQSR-LEQG---LSEHQRHLNAERQRLQEQLKQTEQ-NISSRI 339
Q + E + +EE+ R EQG L E QR ER+R + LK+ +Q R
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER--KFLKEEQQLRCQERE 1405
Query: 340 QKLLQDNQRQKKSSEILKSL---------ENERIRMEQLMSITQEETESLR--RRDVASA 388
Q+L QD R+ + E S E +++R ++ EE + LR R
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 389 MQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQ------------ILSWQQ 436
+Q+L E + +L + E R+ L ++ E D +F++ + QQ
Sbjct: 1466 EEQLLQEREEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ 1523
Query: 437 MDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKL-IETELLQLTQLELKRK-S 494
+ + + + LQE + Q ++D R+ R + +L E E QL++ E RK
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQD-RDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 495 LDTESLQE-------MISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENY 547
L+ + ++ M EQ+ QQL +E+ ++ E ++L E E + RQE
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE-- 1640
Query: 548 WLIQYQRLLNQKPLSLKLQEEGMERQL 574
+ ++ L ++P +L+ + E+QL
Sbjct: 1641 ---RDRKFLEEEP---QLRRQEREQQL 1661
Score = 58.9 bits (141), Expect = 2e-08
Identities = 80/332 (24%), Positives = 146/332 (43%), Gaps = 61/332 (18%)
Query: 268 LEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQ 327
L+ E+R +E LLQ ++D+ ++ Q E G Q+ ER+ L E
Sbjct: 95 LDEEKRARCDGKE--SLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE-LAEG 151
Query: 328 LKQTEQNISSRIQKLLQDNQRQKKSSEILK------SLENERIRMEQLMSITQEET---- 377
+Q+E+ Q+ L+ RQ++ E+ + E R EQL S ET
Sbjct: 152 EEQSEK------QERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205
Query: 378 --ESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQ 435
E LRRR++ + K R + +RQ+ V Q E +E+ W+
Sbjct: 206 DEEQLRRRELLELRR-------KGREEKQQQRRERQDRVFQ------EEEEK-----EWR 247
Query: 436 QMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSL 495
+ +E+ ++K E LQ ++ R+++ + E +L +L + EL+R+
Sbjct: 248 K-----------RETVLRKEE-EKLQEEEPQRQRELQEE----EEQLRKLERQELRRERQ 291
Query: 496 DTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQRL 555
+ E Q+ + ++ L ++ +E+++++EE RE E + E R++ Q +R
Sbjct: 292 EEEQQQQRLRREQ----QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER- 346
Query: 556 LNQKPLSLKLQEEGMERQLVALLEELSAEHYL 587
++ L + +EE E+QL EE E L
Sbjct: 347 -REQQLRREQEEERREQQLRREQEEERREQQL 377
Score = 55.8 bits (133), Expect = 1e-07
Identities = 79/377 (20%), Positives = 165/377 (43%), Gaps = 21/377 (5%)
Query: 232 RDSPDGPTDRFSREELEWQNRFSDYEKRKE-QKMLEKLEFERRLE--LGQREHTQLLQQS 288
R + P R ++ E + ++ E++ E Q+ LE+ + +RR E QR+ Q ++
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Query: 289 SSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQR 348
++++++ E +R L R++ +E+ +Q + R+ + ++ +
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 349 QKKSSEILKSLENERIRMEQLMSITQEETESLRR---------RDVASAMQQMLTESCKN 399
+K+ + + K E + Q QEE E LR+ R QQ L +
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 400 RLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEA 459
R Q ++Q ++ + +ER +Q L +Q ++ + + QE ++
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 460 LQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLL 519
Q +++ +Q+R + +L + L+ Q + + L E Q++ EQ+ QQL
Sbjct: 367 EQ-EEERREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRRE---QQLR 420
Query: 520 KEKQQREEELREILTELEAKSETRQENYWLIQYQR--LLNQKPLSLKLQEEGMERQLVAL 577
+E+Q R E+ E E + + E R++ Q +R L ++ + + ++E ++QL
Sbjct: 421 REQQLRREQ-EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 578 LEELSAEHYLPIFAHHR 594
EE E +L + R
Sbjct: 480 QEEERRERWLKLEEEER 496
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/314 (22%), Positives = 133/314 (42%), Gaps = 44/314 (14%)
Query: 244 REELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQ----REHTQLLQQSSSQKDEILQTV 299
REE + + D + +E+ L + E E++L + RE QLLQ+ Q Q
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ-----QLR 1685
Query: 300 KEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSL 359
++E+ R + + R ER+ LQE+ + Q + + ++ ++ RQ+ E L+
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE--EEQLRQETEQEQLRRQ 1743
Query: 360 ENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACS 419
E R +E+ + E + LRR++ ++ Q+ E + Q L Q
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREE---------EQLRQEREEQQLRSQ--- 1791
Query: 420 SMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIE 479
E D +F++ +Q+ Q + Q+ + K +E Q++ + +++R + +
Sbjct: 1792 ---ESDRKFRE---EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE---RD 1842
Query: 480 TELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAK 539
+ Q + KS E QE+ E+ K +Q+RE +LRE + K
Sbjct: 1843 RQYRAEEQFATQEKSRREE--QELWQEEE----------QKRRQERERKLREEHIRRQQK 1890
Query: 540 SETRQENYWLIQYQ 553
E R I+ Q
Sbjct: 1891 EEQRHRQVGEIKSQ 1904
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/381 (21%), Positives = 163/381 (42%), Gaps = 45/381 (11%)
Query: 240 DRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTV 299
++ REE E + R + +E++ L++ E + E ++ Q L++ +++E+ Q
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ-- 1148
Query: 300 KEEQSRLEQGLSEHQRHLNAERQ-RLQEQLKQTEQNISSRIQKLLQDNQRQ------KKS 352
+EEQ E+ E +R ERQ R +E+L+Q E+ ++ + Q+ +RQ ++
Sbjct: 1149 EEEQLLREE--PEKRRRQELERQYREEEELQQEEE----QLLREEQEKRRQERERQYREE 1202
Query: 353 SEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYES---- 408
E+ + +R R E S + + E + V ++ + +N + +S
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD--NKVYCKGRENEQFRQLEDSQLRD 1260
Query: 409 -QRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQIL--QESAMQKAAFEALQVKKD 465
Q Q +Q E D R Q+ WQQ D++ + L +E K Q +K
Sbjct: 1261 RQSQQDLQHLLGEQQERD-REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 466 LMHRQIRSQIKLIETE---------LLQLTQLELKRKSLDTESLQEMI-----------S 505
L+ + + + ET+ L + + L+R+ D + +E +
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Query: 506 EQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKL 565
EQR ++ LKE+QQ + RE + + R+E L + +R + ++
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 566 QEEGMERQLVALLEELSAEHY 586
+ + ER+ + ++L E +
Sbjct: 1440 RRQERERKFLEEEQQLRQERH 1460
Score = 50.8 bits (120), Expect = 4e-06
Identities = 57/274 (20%), Positives = 123/274 (44%), Gaps = 30/274 (10%)
Query: 240 DRFSREELEWQNRFSDYEKR--KEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQ 297
DR REE E Q R + E++ +E++ L + E ER+ ++ + Q+ +++ +
Sbjct: 1690 DRKFREE-EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748
Query: 298 TVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILK 357
++EEQ R E+ + +R + R +EQL+Q + R Q + +++ ++ ++ +
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ---ESDRKFREEEQLRQ 1805
Query: 358 SLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQA 417
E +++R +Q + E E L+ + ++Q E RQ ++
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ---------------ERDRQYRAEEQ 1850
Query: 418 CSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQ---IRSQ 474
++ + Q++ ++ + + + L+E +++ Q K++ HRQ I+SQ
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR------QQKEEQRHRQVGEIKSQ 1904
Query: 475 IKLIETELLQLTQLELKRKSLDTESLQEMISEQR 508
LL+ + + + L E I EQR
Sbjct: 1905 EGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQR 1938
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 79.3 bits (194), Expect = 1e-14
Identities = 48/134 (35%), Positives = 78/134 (58%), Gaps = 2/134 (1%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQL 119
L + N LTSL P++ + L + L LH N + +P+ +G L LQ L++ N L +
Sbjct: 46 LYMKRNSLTSL-PENLAQ-KLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIV 103
Query: 120 PRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLS 179
IG L L+ L + +N+L+ LP VG+L+ L+TL+IS N + LP+ L +L+ L+
Sbjct: 104 CPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLT 163
Query: 180 LDASAMVYPPREVC 193
+D + + Y PR +C
Sbjct: 164 VDRNRLWYVPRHLC 177
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/160 (29%), Positives = 90/160 (56%), Gaps = 6/160 (3%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQL 119
L +H+N++ ++P++ SL ++ LDL DN L + ++G+L AL+ L + NQL L
Sbjct: 70 LYLHSNNIV-VVPEAIG--SLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFL 126
Query: 120 PRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLS 179
P +G+L +LQTL++ N+L LP+ + SL+ L + N + +P+ L + +L LS
Sbjct: 127 PPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELS 186
Query: 180 LDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYL 219
+ + + + P ++ G + LQ++ ++ + YL
Sbjct: 187 MAGNRLAFLPLDL---GRSRELQYVYVDNNIHLKGLPSYL 223
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 79.3 bits (194), Expect = 1e-14
Identities = 53/156 (33%), Positives = 81/156 (51%), Gaps = 5/156 (3%)
Query: 60 LIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQL 119
LI+ N L SL L L + VLD+HDNQLT+LP + +L LQ LNV N+L L
Sbjct: 87 LIISNNKLQSLTD---DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 120 PRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLS 179
P I NL L+ L ++ N+L + + +L +L L++S N + +P + + +L L+
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 180 LDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPP 215
L ++ + P E+ L C + LE PP
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLD--CNSNLLETIPP 237
Score = 74.3 bits (181), Expect = 4e-13
Identities = 50/157 (31%), Positives = 87/157 (55%), Gaps = 6/157 (3%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
+LDI +L+ +P A + LQK L V N L +LP+ + +L +K L L N+
Sbjct: 109 VLDIHDNQLTSLP-SAIRELENLQK--LNVSHNKL-KILPEE--ITNLRNLKCLYLQHNE 162
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSL 152
LT + + QL+ L+ L++ N L +P S +L+ L LN+ N+LK LP + ++ L
Sbjct: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
Query: 153 RTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPP 189
+ L+ + N ++ +P LA + +LE+L L + + + P
Sbjct: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Score = 73.6 bits (179), Expect = 6e-13
Identities = 55/194 (28%), Positives = 98/194 (50%), Gaps = 30/194 (15%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+S L+ +P +F++ L + L + +N L SL + + +K LD + N L
Sbjct: 179 LDLSNNHLTTVP-ASFSSLSSLVR--LNLSSNELKSL---PAEINRMKRLKHLDCNSNLL 232
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPR-----------------------SIGNLTQLQ 130
+P +L + +L++L + RN+L LP + +L +
Sbjct: 233 ETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSIL 292
Query: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
L+++DNKLK +PD + LRSL L++S N+I LP L ++ L+ L+L+ + + R
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRR 351
Query: 191 EVCGAGTAAILQFL 204
E+ GT +L++L
Sbjct: 352 EIISKGTQEVLKYL 365
Score = 59.7 bits (143), Expect = 9e-09
Identities = 52/196 (26%), Positives = 86/196 (43%), Gaps = 26/196 (13%)
Query: 33 ILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQ 92
ILD S + + IP F K + N L + + L + + +DL N+
Sbjct: 403 ILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEM--VSDVDLSFNK 460
Query: 93 LTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT------- 145
L+ + +L L L L++ N L LP + +L +LQT+N+ N+ K LP+
Sbjct: 461 LSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTL 520
Query: 146 ---------VGE--------LRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYP 188
VG + +L TL++ N++ ++P L + L L LD + P
Sbjct: 521 ETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVP 580
Query: 189 PREVCGAGTAAILQFL 204
+ GTAAIL++L
Sbjct: 581 RAAILMKGTAAILEYL 596
Score = 53.9 bits (128), Expect = 5e-07
Identities = 33/127 (25%), Positives = 62/127 (48%), Gaps = 27/127 (21%)
Query: 79 SLATIKVLDLHDNQLTALPDDLGQLTALQV---LNVERNQLMQLPRSIGNLTQ------- 128
++ T+K+LD D Q T +PD++ + +N +NQL ++P+ + L +
Sbjct: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
Query: 129 -----------------LQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAH 171
L L++++N L LP+ + L L+T+N+S N + LP++L
Sbjct: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
Query: 172 VRTLEML 178
+ TLE +
Sbjct: 517 IFTLETI 523
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/77 (35%), Positives = 45/77 (58%)
Query: 104 TALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQ 163
T L L + N+L L + L L L++ DN+L LP + EL +L+ LN+S N+++
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 164 RLPQMLAHVRTLEMLSL 180
LP+ + ++R L+ L L
Sbjct: 142 ILPEEITNLRNLKCLYL 158
Score = 49.7 bits (117), Expect = 1e-05
Identities = 37/111 (33%), Positives = 65/111 (58%), Gaps = 7/111 (6%)
Query: 32 DILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDN 91
++L + + +L +P F +C +L K L V N + L ++ L L +I VLDL DN
Sbjct: 246 ELLYLRRNKLRFLP--EFPSCSLL--KELHVGENQIEML--EAEHLKHLNSILVLDLRDN 299
Query: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKEL 142
+L ++PD++ L +L+ L++ N + LP S+GNL L+ L ++ N L+ +
Sbjct: 300 KLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTI 349
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/66 (28%), Positives = 35/66 (53%)
Query: 127 TQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMV 186
T L L + +NKL+ L D + L +L L+I N++ LP + + L+ L++ + +
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 187 YPPREV 192
P E+
Sbjct: 142 ILPEEI 147
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 79.0 bits (193), Expect = 1e-14
Identities = 102/408 (25%), Positives = 178/408 (43%), Gaps = 59/408 (14%)
Query: 246 ELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSR 305
E E ++ + + E E +++ L Q+E +L QQ Q D +LQ KE S
Sbjct: 211 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKELSSS 269
Query: 306 LEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENE-RI 364
L Q L Q + E+ +E+LKQT + +L + Q+++++ ++K LE E +
Sbjct: 270 LHQKLCSFQEEMVKEKNLFEEELKQT-------LDELDKLQQKEEQAERLVKQLEEEAKS 322
Query: 365 RMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEM 424
R E+L + ++ + +SA T L+Q Y+S Q+L
Sbjct: 323 RAEELKLLEEKLKGKEAELEKSSAAHTQAT-----LLLQEKYDSMVQSL----------- 366
Query: 425 DERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQ 484
++ Q S++ + ++ L+ S++Q+ A +A + +D+ H QI + + +
Sbjct: 367 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH-QILATESSNQEYVRM 425
Query: 485 LTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKE-----KQQREEELREILTELEAK 539
L L+ K +TE ++E+ ++ L QL ++ KQ +EE R+ E
Sbjct: 426 LLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
Query: 540 SETRQENYWLIQYQRLLNQ-KPLSLKLQEEGMERQLVALLEELSA---------EHYLPI 589
T + N W + Y+ L N+ KP L+L +E+Q ALL E A + Y +
Sbjct: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ--ALLNEHGAAQEQLNKIRDSYAKL 542
Query: 590 FAHHRL-------------SLDLLSQMSP--GDLAKVGVSEAGLQHEI 622
H L + L S++S LAK SE LQ E+
Sbjct: 543 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 590
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 79.0 bits (193), Expect = 1e-14
Identities = 102/408 (25%), Positives = 178/408 (43%), Gaps = 59/408 (14%)
Query: 246 ELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSR 305
E E ++ + + E E +++ L Q+E +L QQ Q D +LQ KE S
Sbjct: 298 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKELSSS 356
Query: 306 LEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENE-RI 364
L Q L Q + E+ +E+LKQT + +L + Q+++++ ++K LE E +
Sbjct: 357 LHQKLCSFQEEMVKEKNLFEEELKQT-------LDELDKLQQKEEQAERLVKQLEEEAKS 409
Query: 365 RMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEM 424
R E+L + ++ + +SA T L+Q Y+S Q+L
Sbjct: 410 RAEELKLLEEKLKGKEAELEKSSAAHTQAT-----LLLQEKYDSMVQSL----------- 453
Query: 425 DERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQ 484
++ Q S++ + ++ L+ S++Q+ A +A + +D+ H QI + + +
Sbjct: 454 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH-QILATESSNQEYVRM 512
Query: 485 LTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKE-----KQQREEELREILTELEAK 539
L L+ K +TE ++E+ ++ L QL ++ KQ +EE R+ E
Sbjct: 513 LLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 571
Query: 540 SETRQENYWLIQYQRLLNQ-KPLSLKLQEEGMERQLVALLEELSA---------EHYLPI 589
T + N W + Y+ L N+ KP L+L +E+Q ALL E A + Y +
Sbjct: 572 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ--ALLNEHGAAQEQLNKIRDSYAKL 629
Query: 590 FAHHRL-------------SLDLLSQMSP--GDLAKVGVSEAGLQHEI 622
H L + L S++S LAK SE LQ E+
Sbjct: 630 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
Score = 40.8 bits (94), Expect = 0.004
Identities = 68/283 (24%), Positives = 136/283 (48%), Gaps = 26/283 (9%)
Query: 322 QRLQEQLKQTEQNI----------SSRIQKLLQDNQRQKKSSEILKSLE-------NERI 364
QR ++Q K+++QN+ S+R K + + +K+ + LK LE ER
Sbjct: 42 QRFKQQ-KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERG 100
Query: 365 RMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQ-MAYESQRQNLVQQACSSMAE 423
++ + + E E + R + +A+++ + S N ++ E R N + ++ S
Sbjct: 101 AQDRRIQDLETELEKMEAR-LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS-EN 158
Query: 424 MDERFQQILSWQQMD-QNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETEL 482
+++ +ILS + M +NK +++ A Q+ LQV + + + + +I +E +L
Sbjct: 159 GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL-EESQGKIAQLEGKL 217
Query: 483 LQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSET 542
+ + + ++ KS +TE L E I E A S +++ + Q EE L+E E+ + ++
Sbjct: 218 VSIEKEKIDEKS-ETEKLLEYIEEISCA-SDQVEKYKLDIAQLEENLKEKNDEILSLKQS 275
Query: 543 RQENYWLIQYQ-RLLNQKPLSLKLQEEGMERQLVALLEELSAE 584
+EN ++ Q LN K L+ ++E + E L+AE
Sbjct: 276 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 318
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 79.0 bits (193), Expect = 1e-14
Identities = 102/408 (25%), Positives = 178/408 (43%), Gaps = 59/408 (14%)
Query: 246 ELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSR 305
E E ++ + + E E +++ L Q+E +L QQ Q D +LQ KE S
Sbjct: 282 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKELSSS 340
Query: 306 LEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENE-RI 364
L Q L Q + E+ +E+LKQT + +L + Q+++++ ++K LE E +
Sbjct: 341 LHQKLCSFQEEMVKEKNLFEEELKQT-------LDELDKLQQKEEQAERLVKQLEEEAKS 393
Query: 365 RMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEM 424
R E+L + ++ + +SA T L+Q Y+S Q+L
Sbjct: 394 RAEELKLLEEKLKGKEAELEKSSAAHTQAT-----LLLQEKYDSMVQSL----------- 437
Query: 425 DERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQ 484
++ Q S++ + ++ L+ S++Q+ A +A + +D+ H QI + + +
Sbjct: 438 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH-QILATESSNQEYVRM 496
Query: 485 LTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKE-----KQQREEELREILTELEAK 539
L L+ K +TE ++E+ ++ L QL ++ KQ +EE R+ E
Sbjct: 497 LLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 555
Query: 540 SETRQENYWLIQYQRLLNQ-KPLSLKLQEEGMERQLVALLEELSA---------EHYLPI 589
T + N W + Y+ L N+ KP L+L +E+Q ALL E A + Y +
Sbjct: 556 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ--ALLNEHGAAQEQLNKIRDSYAKL 613
Query: 590 FAHHRL-------------SLDLLSQMSP--GDLAKVGVSEAGLQHEI 622
H L + L S++S LAK SE LQ E+
Sbjct: 614 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 661
Score = 45.8 bits (107), Expect = 1e-04
Identities = 67/267 (25%), Positives = 134/267 (50%), Gaps = 10/267 (3%)
Query: 322 QRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEI-LKSLENERIRMEQLMSITQEETESL 380
QR ++Q K+++QN++ L + R+ KSSE ++ L ER ++ + + E E +
Sbjct: 42 QRFKQQ-KESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKM 100
Query: 381 RRRDVASAMQQMLTESCKNRLIQ-MAYESQRQNLVQQACSSMAEMDERFQQILSWQQMD- 438
R + +A+++ + S N ++ E R N + ++ S +++ +ILS + M
Sbjct: 101 EAR-LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS-ENGNQKNLRILSLELMKL 158
Query: 439 QNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTE 498
+NK +++ A Q+ LQV + + + + +I +E +L+ + + ++ KS +TE
Sbjct: 159 RNKRETKMRGMMAKQEGMEMKLQVTQRSL-EESQGKIAQLEGKLVSIEKEKIDEKS-ETE 216
Query: 499 SLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQ-RLLN 557
L E I E A S +++ + Q EE L+E E+ + ++ +EN ++ Q LN
Sbjct: 217 KLLEYIEEISCA-SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLN 275
Query: 558 QKPLSLKLQEEGMERQLVALLEELSAE 584
K L+ ++E + E L+AE
Sbjct: 276 VKCQLLEKEKEDHVNRNREHNENLNAE 302
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 79.0 bits (193), Expect = 1e-14
Identities = 102/408 (25%), Positives = 178/408 (43%), Gaps = 59/408 (14%)
Query: 246 ELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSR 305
E E ++ + + E E +++ L Q+E +L QQ Q D +LQ KE S
Sbjct: 297 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKELSSS 355
Query: 306 LEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENE-RI 364
L Q L Q + E+ +E+LKQT + +L + Q+++++ ++K LE E +
Sbjct: 356 LHQKLCSFQEEMVKEKNLFEEELKQT-------LDELDKLQQKEEQAERLVKQLEEEAKS 408
Query: 365 RMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEM 424
R E+L + ++ + +SA T L+Q Y+S Q+L
Sbjct: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQAT-----LLLQEKYDSMVQSL----------- 452
Query: 425 DERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQ 484
++ Q S++ + ++ L+ S++Q+ A +A + +D+ H QI + + +
Sbjct: 453 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH-QILATESSNQEYVRM 511
Query: 485 LTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKE-----KQQREEELREILTELEAK 539
L L+ K +TE ++E+ ++ L QL ++ KQ +EE R+ E
Sbjct: 512 LLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 570
Query: 540 SETRQENYWLIQYQRLLNQ-KPLSLKLQEEGMERQLVALLEELSA---------EHYLPI 589
T + N W + Y+ L N+ KP L+L +E+Q ALL E A + Y +
Sbjct: 571 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ--ALLNEHGAAQEQLNKIRDSYAKL 628
Query: 590 FAHHRL-------------SLDLLSQMSP--GDLAKVGVSEAGLQHEI 622
H L + L S++S LAK SE LQ E+
Sbjct: 629 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 676
Score = 43.9 bits (102), Expect = 5e-04
Identities = 66/280 (23%), Positives = 136/280 (48%), Gaps = 21/280 (7%)
Query: 322 QRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENE---RIRMEQLMSITQEETE 378
QR ++Q K+++QN++ L + R+ KSSE +S +N+ +I +++ + QE
Sbjct: 42 QRFKQQ-KESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGA 100
Query: 379 SLRR-RDVASAMQQM---LTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQ---- 430
RR +D+ + +++M L + + + A + + + + + + +F +
Sbjct: 101 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 160
Query: 431 ----ILSWQQMD-QNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQL 485
ILS + M +NK +++ A Q+ LQV + + + + +I +E +L+ +
Sbjct: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL-EESQGKIAQLEGKLVSI 219
Query: 486 TQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQE 545
+ ++ KS +TE L E I E A S +++ + Q EE L+E E+ + ++ +E
Sbjct: 220 EKEKIDEKS-ETEKLLEYIEEISCA-SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 277
Query: 546 NYWLIQYQ-RLLNQKPLSLKLQEEGMERQLVALLEELSAE 584
N ++ Q LN K L+ ++E + E L+AE
Sbjct: 278 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 317
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 78.2 bits (191), Expect = 3e-14
Identities = 84/351 (23%), Positives = 173/351 (49%), Gaps = 26/351 (7%)
Query: 241 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 300
R + EL+ Q E +++ + + + + LEL Q+ QQ S + E Q+V
Sbjct: 83 RPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVH 142
Query: 301 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNI---SSRIQKLLQDNQ--RQKKSSEI 355
++ + E L Q+ L ++ + Q++L+Q ++ + ++ Q++LQ + +Q+ +
Sbjct: 143 HQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQ 202
Query: 356 LKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQ 415
L + E+++ +QL+ ++ E L+++ Q+ L + + L+Q + Q+Q L Q
Sbjct: 203 LLQQQQEQLQQQQLL----QQQEQLQQQQF-QQQQEQLQQQQQLLLLQQQGQLQQQLLQQ 257
Query: 416 QACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQI 475
Q QQ+L QQ + + QE Q+ + LQ +++ + +Q Q+
Sbjct: 258 QQAQLQ-------QQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQ---QL 307
Query: 476 KLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELR--EIL 533
+ E + ++EL+ +D S QE + +QR L Q+L ++++QR+ +L+ E L
Sbjct: 308 QPPPLEPEEEEEVELELMPVDLGSEQE-LEQQRQELER-QQELERQQEQRQLQLKLQEEL 365
Query: 534 TELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAE 584
+LE + E +Q+ L Q + L P+ L Q++ ++ +L + EL E
Sbjct: 366 QQLEQQLEQQQQQ--LEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLE 414
Score = 76.6 bits (187), Expect = 7e-14
Identities = 95/382 (24%), Positives = 167/382 (43%), Gaps = 44/382 (11%)
Query: 222 ILEQDGIENSRDSPD----GPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELG 277
+LE +E+ PD G S+EE E Q R S ++ + E G
Sbjct: 26 VLELQCLEDGGPGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPG 85
Query: 278 QREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQT-EQNIS 336
QRE L Q Q+ E Q + EQ L + Q HL LQ+Q +Q +Q +S
Sbjct: 86 QRE---LQLQQLEQQPEPQQQPQHEQ------LQQPQPHLE-----LQQQPQQDGQQQLS 131
Query: 337 SRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTES 396
Q+ Q Q+ E+ + ++++ +Q+ +E + L+++ QQ +
Sbjct: 132 QLQQEKHQSVHHQELKPELQLMHQQQQLQPQQV-----QEQQRLQQQQEQLQTQQAQEQQ 186
Query: 397 CKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAA 456
+ Q+ + Q Q L+QQ + + QQ+L Q+ Q + Q QE Q+
Sbjct: 187 VLQQQEQLQQQVQEQQLLQQQQEQLQQ-----QQLLQQQEQLQQQQFQQ-QQEQLQQQQQ 240
Query: 457 FEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQ 516
LQ + L + ++ Q ++ +LL+ Q +L+++ L + Q +Q+ L +
Sbjct: 241 LLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQE 300
Query: 517 QL---------LKEKQQREEELREILTELEAKSETRQENYWLIQYQRL---LNQKPLSLK 564
QL L+ +++ E EL + +L ++ E Q+ L + Q L Q+ L LK
Sbjct: 301 QLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLK 360
Query: 565 LQEE--GMERQLVALLEELSAE 584
LQEE +E+QL ++L +
Sbjct: 361 LQEELQQLEQQLEQQQQQLEQQ 382
Score = 72.4 bits (176), Expect = 1e-12
Identities = 79/300 (26%), Positives = 139/300 (46%), Gaps = 10/300 (3%)
Query: 262 QKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAER 321
Q+ L +L+ E+ + +E LQ Q+ Q V+E+Q RL+Q + Q E+
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQ-RLQQQQEQLQTQQAQEQ 185
Query: 322 QRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLR 381
Q LQ+Q +Q +Q + Q+LLQ Q Q + ++L+ E + + Q ++ + L
Sbjct: 186 QVLQQQ-EQLQQQVQE--QQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLL 242
Query: 382 RRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAE-MDERFQQILSWQQMDQN 440
+QQ L + + +L Q E Q+ L QQ E + ++ QQ L QQ +Q
Sbjct: 243 LLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQL 302
Query: 441 KAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESL 500
+ Q LQ ++ E +V+ +LM + S+ +L + Q EL+R+ + L
Sbjct: 303 Q--QQQLQPPPLEPEEEE--EVELELMPVDLGSEQELEQQRQELERQQELERQQ-EQRQL 357
Query: 501 QEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKP 560
Q + E+ L L+Q ++ +Q+E +L EL A+ + Q +Q + L P
Sbjct: 358 QLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVP 417
Score = 55.8 bits (133), Expect = 1e-07
Identities = 72/291 (24%), Positives = 127/291 (43%), Gaps = 42/291 (14%)
Query: 407 ESQRQNLVQQACSSMAEMDERFQQI---LSWQQMDQNKAISQI--LQESAMQKAAFEALQ 461
E Q Q L QQ E+ QQ L QQ Q Q+ LQ+ Q + L+
Sbjct: 88 ELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELK 147
Query: 462 VKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQE--MISEQRWALSSLLQQLL 519
+ LMH+Q + Q + ++ + +L+ +++ L T+ QE ++ +Q + +Q L
Sbjct: 148 PELQLMHQQQQLQPQQVQEQ----QRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203
Query: 520 KEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLE 579
++QQ + + +++L + E + +Q+ + Q Q L Q+ L LQ++G +Q + +
Sbjct: 204 LQQQQEQLQQQQLLQQQE---QLQQQQFQ--QQQEQLQQQQQLLLLQQQGQLQQQLLQQQ 258
Query: 580 ELSAEHYLPIFAHHRLSLDLLSQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPEL 639
+ + L +L LL Q + Q ++L++ QE L Q +L
Sbjct: 259 QAQLQQQLLEQQQAQLQQQLLLQQQE-------QLQQQQQQQLLQQQQEQLQ----QQQL 307
Query: 640 KPPMGEVVTPTAPQEPPESVRPSAP-----PAELEVQASECVVCLEREAQM 685
+PP P P+E E P ELE Q E LER+ ++
Sbjct: 308 QPP------PLEPEEEEEVELELMPVDLGSEQELEQQRQE----LERQQEL 348
Score = 35.4 bits (80), Expect = 0.19
Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 5/92 (5%)
Query: 238 PTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQ 297
P D S +ELE Q ++ + Q+ LE+ + +R+L+L +E Q L+Q Q+ + L+
Sbjct: 326 PVDLGSEQELEQQR-----QELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLE 380
Query: 298 TVKEEQSRLEQGLSEHQRHLNAERQRLQEQLK 329
+ + L Q+ + E +Q +L+
Sbjct: 381 QQEVQLELTPVELGAQQQEVQLELTPVQPELQ 412
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 77.8 bits (190), Expect = 3e-14
Identities = 57/184 (30%), Positives = 91/184 (49%), Gaps = 23/184 (12%)
Query: 26 KEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSL----- 80
+E D ++D+S +L P C + L + NHL SL P+ L +L
Sbjct: 26 REMPLDKMVDLSGSQLRRFPLHV---CSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
Query: 81 ------------ATIK---VLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGN 125
T+K +L L +N+L LP +L L L+ L +E N L QLP +
Sbjct: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
Query: 126 LTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
L+ L+TL+ N L+ LP + L+ LRT+ +SGN + P +L H+ LE++ +D +++
Sbjct: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
Query: 186 VYPP 189
Y P
Sbjct: 203 RYFP 206
Score = 67.4 bits (163), Expect = 4e-11
Identities = 39/107 (36%), Positives = 63/107 (58%)
Query: 86 LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDT 145
L L DN L +LP +LGQL LQ+L ++ N LP+ + L QL L + +NKL +LP
Sbjct: 57 LYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSE 116
Query: 146 VGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
+ L++LRTL I N + +LP ++ + L+ L ++A+ P ++
Sbjct: 117 LSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQL 163
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/110 (31%), Positives = 53/110 (48%)
Query: 84 KVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELP 143
K++DL +QL P + L L + N L LP +G L LQ L + N K LP
Sbjct: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
Query: 144 DTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
V L+ L L + N++ LP L+ ++ L L ++A+ + P VC
Sbjct: 92 QVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVC 141
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/94 (26%), Positives = 53/94 (56%)
Query: 99 DLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNIS 158
DL ++ +++++ +QL + P + + +L L + DN L LP +G+L++L+ L +
Sbjct: 24 DLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALD 83
Query: 159 GNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
N + LPQ++ ++ L +L L + + P E+
Sbjct: 84 FNNFKALPQVVCTLKQLCILYLGNNKLCDLPSEL 117
Score = 34.3 bits (77), Expect = 0.42
Identities = 20/70 (28%), Positives = 35/70 (50%)
Query: 132 LNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPRE 191
+++ ++L+ P V R L L +S N + LP L ++ L++L+LD + P+
Sbjct: 34 VDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQV 93
Query: 192 VCGAGTAAIL 201
VC IL
Sbjct: 94 VCTLKQLCIL 103
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 76.6 bits (187), Expect = 7e-14
Identities = 50/167 (29%), Positives = 84/167 (50%), Gaps = 23/167 (13%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKV-------- 85
LD+SK + + G +TC+ LQ L++ +N L L SL ++ T+K+
Sbjct: 235 LDVSKNNIEMVEEG-ISTCENLQD--LLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291
Query: 86 ------------LDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
LD N++ ALP +GQLT L+ + N L QLP IG+ + L
Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLF 351
Query: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180
+ NKL+ LP+ +G+++ L+ +N+S N ++ LP ++ L + L
Sbjct: 352 LHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/164 (26%), Positives = 92/164 (56%), Gaps = 5/164 (3%)
Query: 53 KVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVE 112
++ + ++L + N L +LPK+ + L+ ++ LDL N+ T +P+ L QL+ L+ ++
Sbjct: 159 RLTKLQILELRENQL-KMLPKTMNRLT--QLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215
Query: 113 RNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHV 172
N+L +P IG+L QL L+V N ++ + + + +L+ L +S N +Q+LP+ + +
Sbjct: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275
Query: 173 RTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPS 216
+ + L +D + ++Y P + G ++ + C + +E P S
Sbjct: 276 KNITTLKIDENQLMYLPDSI--GGLISVEELDCSFNEVEALPSS 317
Score = 72.4 bits (176), Expect = 1e-12
Identities = 56/213 (26%), Positives = 89/213 (41%), Gaps = 51/213 (23%)
Query: 23 CLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLAT 82
CL E LD S C L ++P F K L++ L + N + L PK L + +
Sbjct: 16 CLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEE--LYLDANQIEEL-PKQ--LFNCQS 70
Query: 83 IKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSI------------------- 123
+ L L DN LT LP + L L+ L+V +N + + P +I
Sbjct: 71 LHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKL 130
Query: 124 ---------------------------GNLTQLQTLNVKDNKLKELPDTVGELRSLRTLN 156
G LT+LQ L +++N+LK LP T+ L L L+
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
Query: 157 ISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPP 189
+ NE +P++L + L+ +DA+ + + P
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
Score = 72.0 bits (175), Expect = 2e-12
Identities = 63/299 (21%), Positives = 133/299 (44%), Gaps = 16/299 (5%)
Query: 88 LHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVG 147
L N L LP+ +G L + L ++ NQLM LP SIG L ++ L+ N+++ LP ++G
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 148 ELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKE 207
+L +LRT N +Q+LP + + + +L L ++ + P E+ ++ +
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL--SD 377
Query: 208 SGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELE---WQNRFSDYEKRKEQKM 264
+ L+ P S L L + +++ P P + + E + N + R E M
Sbjct: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437
Query: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324
+ + + L ++ Q+ ++ E++ E+ + +L
Sbjct: 438 F--------ISDNESFNPSLWEEQRKQRAQVAFECDEDKD--EREAPPREGNLKRYPTPY 487
Query: 325 QEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRR 383
++LK + + + + + L+D + + S LK E+++ + + T E T +++ +
Sbjct: 488 PDELKNMVKTVQTIVHR-LKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSK 545
Score = 71.2 bits (173), Expect = 3e-12
Identities = 46/147 (31%), Positives = 77/147 (52%), Gaps = 6/147 (4%)
Query: 34 LDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQL 93
LD+SK + E P CKVL ++ N ++ L LL+L L L+D L
Sbjct: 97 LDVSKNGIQEFPEN-IKNCKVLT--IVEASVNPISKLPDGFSQLLNLTQ---LYLNDAFL 150
Query: 94 TALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLR 153
LP + G+LT LQ+L + NQL LP+++ LTQL+ L++ N+ E+P+ + +L L+
Sbjct: 151 EFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLK 210
Query: 154 TLNISGNEIQRLPQMLAHVRTLEMLSL 180
+ N + +P + ++ L L +
Sbjct: 211 EFWMDANRLTFIPGFIGSLKQLTYLDV 237
Score = 69.7 bits (169), Expect = 9e-12
Identities = 48/163 (29%), Positives = 81/163 (49%), Gaps = 14/163 (8%)
Query: 34 LDISKCELSEIPFGAFATCKVLQK----KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
LD+ E +E+P +VL++ K + N LT +P SL + LD+
Sbjct: 189 LDLGSNEFTEVP-------EVLEQLSGLKEFWMDANRLT-FIPGFIG--SLKQLTYLDVS 238
Query: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGEL 149
N + + + + LQ L + N L QLP +IG+L + TL + +N+L LPD++G L
Sbjct: 239 KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
Query: 150 RSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
S+ L+ S NE++ LP + + L + D + + P E+
Sbjct: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
Score = 37.7 bits (86), Expect = 0.038
Identities = 53/265 (20%), Positives = 112/265 (42%), Gaps = 33/265 (12%)
Query: 124 GNLTQLQTLNVKDNKLKELPDTVGEL-RSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDA 182
G + TL+ L+++P + ++L L + N+I+ LP+ L + ++L LSL
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 183 SAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILE--QDGIENSRDSPDGPTD 240
+ + P + A + + ++G++ +P + +L + + PDG +
Sbjct: 79 NDLTTLPASI--ANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQ 136
Query: 241 RFSREELEWQNRFSDY--------------EKRKEQ-----KMLEKLEFERRLELGQREH 281
+ +L + F ++ E R+ Q K + +L RL+LG E
Sbjct: 137 LLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF 196
Query: 282 T---QLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISS- 337
T ++L+Q S K+ + + G + +L+ + ++ E+ IS+
Sbjct: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE----MVEEGISTC 252
Query: 338 -RIQKLLQDNQRQKKSSEILKSLEN 361
+Q LL + ++ E + SL+N
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKN 277
Score = 35.0 bits (79), Expect = 0.24
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 26/84 (30%)
Query: 59 VLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
VL +H+ N+L LP+++G + L+V+N+ N+L
Sbjct: 349 VLFLHS--------------------------NKLETLPEEMGDMQKLKVINLSDNRLKN 382
Query: 119 LPRSIGNLTQLQTLNVKDNKLKEL 142
LP S L QL + + DN+ K L
Sbjct: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,007,772
Number of Sequences: 37866
Number of extensions: 1195583
Number of successful extensions: 19066
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 427
Number of HSP's successfully gapped in prelim test: 1231
Number of HSP's that attempted gapping in prelim test: 9897
Number of HSP's gapped (non-prelim): 5698
length of query: 723
length of database: 18,247,518
effective HSP length: 110
effective length of query: 613
effective length of database: 14,082,258
effective search space: 8632424154
effective search space used: 8632424154
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.