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Search of human proteins with 52486327
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
(592 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 1225 0.0
gi|133908623 protein kinase C, iota [Homo sapiens] 876 0.0
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 835 0.0
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 835 0.0
gi|4885563 protein kinase C, epsilon [Homo sapiens] 399 e-111
gi|28557781 protein kinase C, eta [Homo sapiens] 380 e-105
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 367 e-101
gi|4506067 protein kinase C, alpha [Homo sapiens] 364 e-100
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 362 e-100
gi|13384594 protein kinase C, gamma [Homo sapiens] 344 1e-94
gi|47157325 protein kinase C, delta [Homo sapiens] 343 3e-94
gi|31377782 protein kinase C, delta [Homo sapiens] 343 3e-94
gi|5453976 protein kinase C, theta [Homo sapiens] 330 2e-90
gi|4502023 AKT2 kinase [Homo sapiens] 312 5e-85
gi|62241015 AKT1 kinase [Homo sapiens] 300 2e-81
gi|62241013 AKT1 kinase [Homo sapiens] 300 2e-81
gi|62241011 AKT1 kinase [Homo sapiens] 300 2e-81
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 300 2e-81
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 298 1e-80
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 295 6e-80
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 295 6e-80
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 289 6e-78
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 289 6e-78
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 289 6e-78
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 289 6e-78
gi|5453974 protein kinase N2 [Homo sapiens] 288 7e-78
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 1e-77
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 1e-77
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 270 4e-72
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 270 4e-72
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 1225 bits (3170), Expect = 0.0
Identities = 592/592 (100%), Positives = 592/592 (100%)
Query: 1 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 60
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
Sbjct: 1 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 60
Query: 61 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 120
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
Sbjct: 61 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 120
Query: 121 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 180
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
Sbjct: 121 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 180
Query: 181 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 240
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
Sbjct: 181 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 240
Query: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 301 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI 360
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
Sbjct: 301 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI 360
Query: 361 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP 420
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
Sbjct: 361 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP 420
Query: 421 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 480
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
Sbjct: 421 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 480
Query: 481 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 540
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
Sbjct: 481 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 540
Query: 541 DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 541 DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 876 bits (2264), Expect = 0.0
Identities = 429/589 (72%), Positives = 493/589 (83%), Gaps = 17/589 (2%)
Query: 11 GSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDP 67
GSG +VR+KA+Y GDI IT + + +FE LC EVRDMC + T+KW+D EGDP
Sbjct: 18 GSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDP 77
Query: 68 CTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYR 127
CTVSSQ+ELEEAFRL +D L+IHVFP PE+PG+PCPGEDKSIYRRGARRWRKLY
Sbjct: 78 CTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYC 137
Query: 128 ANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSV 187
ANGH FQAKRFNRRA+C C++RIWGL RQGY+CINCKLLVHK+CH LV + C +H
Sbjct: 138 ANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS--- 194
Query: 188 MPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQ 245
+P QEP P+D + +D I Y SS H+S+ E+ K ++ + K S
Sbjct: 195 LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASS 247
Query: 246 GLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFE 305
LGLQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFE
Sbjct: 248 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 307
Query: 306 QASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALN 365
QAS++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN
Sbjct: 308 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 367
Query: 366 FLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRG 425
+LHERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRG
Sbjct: 368 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 427
Query: 426 EEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
E+YGFSVDWWALGVLMFEMMAGRSPFDI+ +DNPD NTEDYLFQVILEK IRIPR LSV
Sbjct: 428 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 487
Query: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543
KA+ VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++
Sbjct: 488 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEF 547
Query: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
GLDNFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 548 GLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 835 bits (2157), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 184 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 243
MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
Query: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 303
SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 304 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 363
FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 364 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 423
LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 424 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543
KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 835 bits (2157), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 184 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 243
MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
Query: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 303
SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 304 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 363
FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 364 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 423
LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 424 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543
KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 399 bits (1024), Expect = e-111
Identities = 217/501 (43%), Positives = 299/501 (59%), Gaps = 52/501 (10%)
Query: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC---------- 180
H F + +C C +WGL RQG +C CK+ VH+RC V C
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302
Query: 181 -----------------RKHM----DSVMPSQ--EPPVDDKNEDA----------DLPSE 207
RK + +S P+ P +D+++ A +L +
Sbjct: 303 LADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENN 362
Query: 208 ETDGIAYISSSRKHDSIKD-DSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKV 266
+++ + +H + D + + P +G ++ LGL +F+ I+V+G+GS+ KV
Sbjct: 363 IRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKV 422
Query: 267 LLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRL 326
+L LK D++YA+KV+KK+++ D+D+D TEK + A +P+L L+ CFQT RL
Sbjct: 423 MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482
Query: 327 FLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDA 386
F V+EYVNGGDLMF +QR RK E +RFYAAE+ AL FLH+ G+IYRDLKLDN+LLDA
Sbjct: 483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA 542
Query: 387 DGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMA 446
+GH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ EYG SVDWWALGVLM+EMMA
Sbjct: 543 EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 602
Query: 447 GRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGC-RP 505
G+ PF+ DN ED LF+ IL + P +LS +A +LK F+ K+P +RLGC
Sbjct: 603 GQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAS 655
Query: 506 QTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDED 565
Q G IK H FF+ IDW LLE+K+ PPF+P+I ++NFD FT E LT DE
Sbjct: 656 QNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEA 715
Query: 566 AIKRIDQSEFEGFEYINPLLL 586
+K+I+Q EF+GF Y L+
Sbjct: 716 IVKQINQEEFKGFSYFGEDLM 736
Score = 64.7 bits (156), Expect = 2e-10
Identities = 31/77 (40%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWG-LARQGYRCINCKLLVHKRCHG 174
R+GA R R++++ NGH F A + YC C + IWG + +QGY+C C +VHKRCH
Sbjct: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
Query: 175 LVPLTCRKHMDSVMPSQ 191
L+ C P Q
Sbjct: 215 LIITKCAGLKKQETPDQ 231
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 380 bits (976), Expect = e-105
Identities = 197/455 (43%), Positives = 270/455 (59%), Gaps = 19/455 (4%)
Query: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190
H F + +C C +WG+ RQG +C CK+ VH RC V C + + +
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305
Query: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQ 250
P + +S S K+ S++ + G+ S LG+
Sbjct: 306 LAGM-------GLQPGNISPTSKLVSRSTLRRQGKESSKEGNGI-----GVNSSNRLGID 353
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
+F+ IRV+G+GS+ KV+L R+K+ +YA+KV+KK+++ D+D++ TEK + A ++
Sbjct: 354 NFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNH 413
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFL L CFQT RLF V+E+VNGGDLMFH+Q+ R+ E ARFYAAEI AL FLH++
Sbjct: 414 PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK 473
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
GIIYRDLKLDNVLLD +GH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+ YG
Sbjct: 474 GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP 533
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWWA+GVL++EM+ G +PF + ED LF+ IL + P +L A+ +LK
Sbjct: 534 AVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPTWLHEDATGILK 586
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
F+ K+P RLG Q G I H FF+ IDW L +Q PPF+P+I + NFD
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 646
Query: 551 QFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 585
F E LTP DE + I+Q EF F Y++P L
Sbjct: 647 DFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
Score = 63.5 bits (153), Expect = 5e-10
Identities = 28/68 (41%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Query: 123 RKLYRANGHLFQAKRFNRRAYCGQCSERIWGL-ARQGYRCINCKLLVHKRCHGLV--PLT 179
R++++ NGH F A + YC C E IWG+ +QGY+C C +VHKRCH L+ T
Sbjct: 164 RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACT 223
Query: 180 CRKHMDSV 187
C+ +++ V
Sbjct: 224 CQNNINKV 231
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 367 bits (941), Expect = e-101
Identities = 175/335 (52%), Positives = 234/335 (69%), Gaps = 8/335 (2%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
L DF+ + V+G+GS+ KV+L K D++YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ + E HA FYAAEI I L FL
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
+GIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ +S +A +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
KG + K P +RLGC P+ G DIK HAFFR IDW+ LE+K+ PP++P+ D NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630
Query: 549 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
D +FT +PV+LTP D+ I +DQ+EF GF Y NP
Sbjct: 631 DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665
Score = 69.3 bits (168), Expect = 9e-12
Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 106 PCPGEDKSIY--RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCIN 163
P GE+ ++ R+GA R + ++ H F A+ F + +C C++ IWG +QG++C
Sbjct: 10 PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
Query: 164 CKLLVHKRCHGLVPLTC 180
C +VHKRCH V +C
Sbjct: 70 CCFVVHKRCHEFVTFSC 86
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
CPG DK R + H F+ ++ +C C ++GL QG +C C +
Sbjct: 86 CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
Query: 167 LVHKRCHGLVPLTC 180
VHKRC VP C
Sbjct: 138 NVHKRCVMNVPSLC 151
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 364 bits (935), Expect = e-100
Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)
Query: 228 SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 287
SED K + +D +K++ DF+ + V+G+GS+ KV+L K +++YA+K++KK++
Sbjct: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374
Query: 288 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 347
V D+D++ EK V PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ K
Sbjct: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434
Query: 348 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 407
E A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G T
Sbjct: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494
Query: 408 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 467
T TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF D ED LF
Sbjct: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547
Query: 468 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 527
Q I+E + P+ LS +A + KG + K P +RLGC P+ G D++ HAFFR IDW+ LE
Sbjct: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606
Query: 528 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
++ PPF+P++ G +NFD FT LTP D+ I IDQS+FEGF Y+NP
Sbjct: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
Score = 66.6 bits (161), Expect = 6e-11
Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 13/90 (14%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175
R+GA R + ++ H F A+ F + +C C++ IWG +QG++C C +VHKRCH
Sbjct: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
Query: 176 VPLTCRKHMDSVMPSQEPPVDDKNEDADLP 205
V +C P DK D D P
Sbjct: 82 VTFSC-------------PGADKGPDTDDP 98
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 8/74 (10%)
Query: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
CPG DK R + H F+ + +C C ++GL QG +C C +
Sbjct: 86 CPGADKGPDTDDPR--------SKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137
Query: 167 LVHKRCHGLVPLTC 180
VHK+C VP C
Sbjct: 138 NVHKQCVINVPSLC 151
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 362 bits (929), Expect = e-100
Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
L DF+ + V+G+GS+ KV+L K D++YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ + E HA FYAAEI I L FL
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
+GIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ +S +A +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
KG + K P +RLGC P+ G DIK HAFFR IDW+ LE+K+ PP++P+ +NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629
Query: 549 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 589
D FT P LTP D++ I+ IDQSEFEGF ++N L E
Sbjct: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
Score = 69.3 bits (168), Expect = 9e-12
Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 106 PCPGEDKSIY--RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCIN 163
P GE+ ++ R+GA R + ++ H F A+ F + +C C++ IWG +QG++C
Sbjct: 10 PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69
Query: 164 CKLLVHKRCHGLVPLTC 180
C +VHKRCH V +C
Sbjct: 70 CCFVVHKRCHEFVTFSC 86
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
CPG DK R + H F+ ++ +C C ++GL QG +C C +
Sbjct: 86 CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137
Query: 167 LVHKRCHGLVPLTC 180
VHKRC VP C
Sbjct: 138 NVHKRCVMNVPSLC 151
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 344 bits (883), Expect = 1e-94
Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)
Query: 247 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 306
L + DF + V+G+GS+ KV+L + +D++YA+K++KK+++ D+D+D EK V
Sbjct: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405
Query: 307 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 361
P FL LHS FQT RL+ V+EYV GGDLM+H+Q+ K E HA FYAAEI
Sbjct: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
Query: 362 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 421
I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
Query: 422 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 481
I+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+ + P+ L
Sbjct: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578
Query: 482 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 541
S +A + KGFL K P +RLG P G I++H FFR IDW+ LE+ + PPF+P+
Sbjct: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637
Query: 542 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
G +NFD FT LTP D + IDQ++F+GF Y+NP
Sbjct: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
Score = 64.3 bits (155), Expect = 3e-10
Identities = 24/65 (36%), Positives = 38/65 (58%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175
R+GA R + ++ H F A+ F + +C C++ IWG+ +QG +C C +VH+RCH
Sbjct: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEF 80
Query: 176 VPLTC 180
V C
Sbjct: 81 VTFEC 85
Score = 47.8 bits (112), Expect = 3e-05
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
CPG K R N H F+ ++ +C C ++GL QG +C C++
Sbjct: 85 CPGAGKGPQTDDPR--------NKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEM 136
Query: 167 LVHKRCHGLVPLTC 180
VH+RC VP C
Sbjct: 137 NVHRRCVRSVPSLC 150
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 343 bits (880), Expect = 3e-94
Identities = 185/456 (40%), Positives = 268/456 (58%), Gaps = 21/456 (4%)
Query: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190
H F+ + +C C +WGL +QG +C +C + VH +C V C + + +
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
Query: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQG---L 247
+ +D S E GI Y +K +D +D G G KI +G
Sbjct: 291 LNQVTQRASRRSDSASSEPVGI-YQGFEKKTGVAGEDMQDNS----GTYG-KIWEGSSKC 344
Query: 248 GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
+ +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V A
Sbjct: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA 404
Query: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI L FL
Sbjct: 405 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL 464
Query: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
H +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL+G +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++ ++
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITKESKD 577
Query: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
+L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++ N
Sbjct: 578 ILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSN 632
Query: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
FD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 633 FDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Score = 57.4 bits (137), Expect = 4e-08
Identities = 22/57 (38%), Positives = 33/57 (57%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRC 172
RRGA + K++ H F A F + +C C + +WGL +QGY+C C +HK+C
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKC 200
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 343 bits (880), Expect = 3e-94
Identities = 185/456 (40%), Positives = 268/456 (58%), Gaps = 21/456 (4%)
Query: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPS 190
H F+ + +C C +WGL +QG +C +C + VH +C V C + + +
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290
Query: 191 QEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQG---L 247
+ +D S E GI Y +K +D +D G G KI +G
Sbjct: 291 LNQVTQRASRRSDSASSEPVGI-YQGFEKKTGVAGEDMQDNS----GTYG-KIWEGSSKC 344
Query: 248 GLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA 307
+ +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V A
Sbjct: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA 404
Query: 308 SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 367
+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI L FL
Sbjct: 405 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL 464
Query: 368 HERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
H +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL+G +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++ ++
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITKESKD 577
Query: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
+L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++ N
Sbjct: 578 ILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSN 632
Query: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
FD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 633 FDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Score = 57.4 bits (137), Expect = 4e-08
Identities = 22/57 (38%), Positives = 33/57 (57%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRC 172
RRGA + K++ H F A F + +C C + +WGL +QGY+C C +HK+C
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKC 200
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 330 bits (846), Expect = 2e-90
Identities = 185/484 (38%), Positives = 270/484 (55%), Gaps = 47/484 (9%)
Query: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC---------- 180
H F+ + +C C +WGLARQG +C C + VH RC V C
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEA 291
Query: 181 ----------RKHMDSVMPSQEPPVDD------KNEDAD--LPS---EETDGIAYISSSR 219
R D+ +E PV+ KNE LP+ E GI++ S
Sbjct: 292 LAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLD 351
Query: 220 KHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYA 279
+ D + E P ++ + + L ++DF L +++G+GS+ KV L KK +Q +A
Sbjct: 352 EVDKMCHLPE---PELN-KERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407
Query: 280 MKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLM 339
+K +KK++V D+D++ EK V A +PFL + FQT LF V+EY+NGGDLM
Sbjct: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467
Query: 340 FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCK 399
+H+Q K A FYAAEI + L FLH +GI+YRDLKLDN+LLD DGHIK+ D+GMCK
Sbjct: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527
Query: 400 EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPD 459
E + T+TFCGTP+YIAPEIL G++Y SVDWW+ GVL++EM+ G+SPF
Sbjct: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH------G 581
Query: 460 MNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFR 519
+ E+ + ++ P PR+L +A +L ++P++RLG R DI+ H FR
Sbjct: 582 QDEEELFHSIRMDNPF-YPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFR 635
Query: 520 SIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFE 579
I+W+ LE+K+ PPF+P++ + NFD +F +E +L+ D I +DQ+ F F
Sbjct: 636 EINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 695
Query: 580 YINP 583
++NP
Sbjct: 696 FMNP 699
Score = 58.9 bits (141), Expect = 1e-08
Identities = 30/90 (33%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175
RRGA + K++ H F A F + +C C E +WGL +QGY+C C +HK+C
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
Query: 176 VPLTCRKHMDSVMPSQEPPVDDKNEDADLP 205
V C S + S+E + D+P
Sbjct: 205 VIAKC---TGSAINSRETMFHKERFKIDMP 231
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 312 bits (800), Expect = 5e-85
Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE V Q +
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI AL +LH
Sbjct: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +Y
Sbjct: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
G +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR LS +A +
Sbjct: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T + F
Sbjct: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439
Query: 549 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 580
D +FT++ + +TP D D++ ++ ++ F F Y
Sbjct: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 2e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 369 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 580
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 2e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 369 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 580
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 2e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 369 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 580
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 300 bits (768), Expect = 2e-81
Identities = 151/338 (44%), Positives = 218/338 (64%), Gaps = 15/338 (4%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 549 DTQFTSEPVQLTPD---DEDAIKRID---QSEFEGFEY 580
D +FT++ + +TP DED + +D + F F Y
Sbjct: 436 DEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSY 473
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 298 bits (762), Expect = 1e-80
Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)
Query: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
Query: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 549 DTQFTSEPVQLTPDDE 564
D +FT++ + +TP ++
Sbjct: 436 DEEFTAQTITITPPEK 451
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 295 bits (756), Expect = 6e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 580
+FT E V TPD A S F GF Y
Sbjct: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 295 bits (756), Expect = 6e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 580
+FT E V TPD A S F GF Y
Sbjct: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 289 bits (739), Expect = 6e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
+FT EPV +PD + ++ F GF Y P
Sbjct: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 289 bits (739), Expect = 6e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 230
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 231 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 290
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 291 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 343
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 344 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 401
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
+FT EPV +PD + ++ F GF Y P
Sbjct: 402 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 289 bits (739), Expect = 6e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
+FT EPV +PD + ++ F GF Y P
Sbjct: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 289 bits (739), Expect = 6e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482
Query: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
+FT EPV +PD + ++ F GF Y P
Sbjct: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 288 bits (738), Expect = 7e-78
Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)
Query: 203 DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 250
D+P ++++ + I + R K SE KP G++ I + LQ
Sbjct: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 309
DF V+GRG + KVLL K ++++A+K +KK + +++D + EK +FE +S
Sbjct: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
Query: 310 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
+PFLV L +CFQT + V+EY GGDLM H+ E A FYAA + + L +LH
Sbjct: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
Query: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
E I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L Y
Sbjct: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
Query: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
+VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +A +
Sbjct: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
Query: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
++ L ++P+ RLG + D+K H FFR IDW L K+ PPF P I + NF
Sbjct: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
Query: 549 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 581
D +FTSE LTP E I ++ E F F+YI
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 1e-77
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
Query: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583
FT E P + + +I E F GF Y P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 1e-77
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
Query: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
Query: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583
FT E P + + +I E F GF Y P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 270 bits (689), Expect = 4e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 247 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 306
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
Query: 307 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 364
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734
Query: 365 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 424
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
Query: 425 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 484
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847
Query: 485 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 544
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906
Query: 545 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 581
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 270 bits (689), Expect = 4e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 247 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 306
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 307 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 364
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 670 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 728
Query: 365 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 424
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 729 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 788
Query: 425 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 484
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 789 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 841
Query: 485 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 544
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 842 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 900
Query: 545 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 581
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 901 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,927,811
Number of Sequences: 37866
Number of extensions: 1219800
Number of successful extensions: 5071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 2800
Number of HSP's gapped (non-prelim): 1099
length of query: 592
length of database: 18,247,518
effective HSP length: 108
effective length of query: 484
effective length of database: 14,157,990
effective search space: 6852467160
effective search space used: 6852467160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.