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Search of human proteins with 51972240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51972240 pleckstrin homology domain containing, family G
(with RhoGef domain) member 7 [Homo sapiens]
(379 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51972240 pleckstrin homology domain containing, family G (wit... 766 0.0
gi|38373682 pleckstrin homology domain containing family G membe... 101 1e-21
gi|111154084 pleckstrin homology domain containing family G memb... 101 1e-21
gi|111154088 pleckstrin homology domain containing family G memb... 101 1e-21
gi|111154080 pleckstrin homology domain containing family G memb... 101 1e-21
gi|111154078 pleckstrin homology domain containing family G memb... 101 1e-21
gi|222080070 pleckstrin homology domain-containing family G memb... 93 5e-19
gi|222080068 pleckstrin homology domain-containing family G memb... 93 5e-19
gi|222080066 pleckstrin homology domain-containing family G memb... 93 5e-19
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 72 1e-12
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 68 2e-11
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 68 2e-11
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 66 6e-11
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 61 2e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 61 2e-09
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 60 4e-09
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 57 2e-08
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 54 2e-07
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 54 2e-07
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 54 2e-07
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 54 2e-07
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 54 3e-07
gi|166197690 neuronal guanine nucleotide exchange factor isoform... 51 2e-06
gi|166197688 neuronal guanine nucleotide exchange factor isoform... 51 2e-06
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 50 4e-06
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 50 4e-06
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 49 1e-05
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 48 1e-05
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 48 1e-05
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 48 1e-05
>gi|51972240 pleckstrin homology domain containing, family G (with
RhoGef domain) member 7 [Homo sapiens]
Length = 379
Score = 766 bits (1979), Expect = 0.0
Identities = 379/379 (100%), Positives = 379/379 (100%)
Query: 1 MIFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLD 60
MIFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLD
Sbjct: 1 MIFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLD 60
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPE 120
FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPE
Sbjct: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPE 120
Query: 121 LLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFR 180
LLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFR
Sbjct: 121 LLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFR 180
Query: 181 YLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLD 240
YLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLD
Sbjct: 181 YLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLD 240
Query: 241 VYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRL 300
VYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRL
Sbjct: 241 VYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRL 300
Query: 301 VVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
VVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK
Sbjct: 301 VVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
Query: 361 SQETKKISLFTLPAESSEI 379
SQETKKISLFTLPAESSEI
Sbjct: 361 SQETKKISLFTLPAESSEI 379
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 101 bits (251), Expect = 1e-21
Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)
Query: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60
+F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D
Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119
F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL +
Sbjct: 421 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 478
Query: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179
++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+
Sbjct: 479 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 538
Query: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232
+ I + + + + + KE + ++ +P +R LL EG L +
Sbjct: 539 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 593
Query: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291
E +DVY FLF D LLVTK +K+ V+
Sbjct: 594 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 627
Query: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351
P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I
Sbjct: 628 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Query: 352 TTA 354
A
Sbjct: 680 YNA 682
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 101 bits (251), Expect = 1e-21
Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)
Query: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60
+F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D
Sbjct: 438 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 497
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119
F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL +
Sbjct: 498 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 555
Query: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179
++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+
Sbjct: 556 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 615
Query: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232
+ I + + + + + KE + ++ +P +R LL EG L +
Sbjct: 616 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 670
Query: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291
E +DVY FLF D LLVTK +K+ V+
Sbjct: 671 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 704
Query: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351
P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I
Sbjct: 705 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 756
Query: 352 TTA 354
A
Sbjct: 757 YNA 759
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 101 bits (251), Expect = 1e-21
Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)
Query: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60
+F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D
Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119
F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL +
Sbjct: 421 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 478
Query: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179
++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+
Sbjct: 479 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 538
Query: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232
+ I + + + + + KE + ++ +P +R LL EG L +
Sbjct: 539 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 593
Query: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291
E +DVY FLF D LLVTK +K+ V+
Sbjct: 594 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 627
Query: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351
P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I
Sbjct: 628 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Query: 352 TTA 354
A
Sbjct: 680 YNA 682
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 101 bits (251), Expect = 1e-21
Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)
Query: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60
+F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D
Sbjct: 361 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 420
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119
F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL +
Sbjct: 421 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 478
Query: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179
++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+
Sbjct: 479 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 538
Query: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232
+ I + + + + + KE + ++ +P +R LL EG L +
Sbjct: 539 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 593
Query: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291
E +DVY FLF D LLVTK +K+ V+
Sbjct: 594 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 627
Query: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351
P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I
Sbjct: 628 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 679
Query: 352 TTA 354
A
Sbjct: 680 YNA 682
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 101 bits (251), Expect = 1e-21
Identities = 86/363 (23%), Positives = 159/363 (43%), Gaps = 51/363 (14%)
Query: 2 IFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASE-ISSSLD 60
+F+ L LQ L +V+ RLF+N+ E+ Q S+ + + + + D
Sbjct: 417 LFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGD 476
Query: 61 FISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESL-RQRDDFGIYLKWCEQNEQCRRLHVP 119
F+ + GSL + + YC+ + Y+ L R D F Y+ W E++ QC+RL +
Sbjct: 477 FLKGFKMF--GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLS 534
Query: 120 ELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKF 179
++L P QRLT+YPLLLK++ +++ + K + ++ VE+ I + ++ Q+
Sbjct: 535 DMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRL 594
Query: 180 RYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSP-------TSRHLLYEGKLTL 232
+ I + + + + + KE + ++ +P +R LL EG L +
Sbjct: 595 AAVVSRIDAYEVVESSS-----DEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 649
Query: 233 AE-STRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVL 291
E +DVY FLF D LLVTK +K+ V+
Sbjct: 650 KEGKDSKMDVYCFLFTDLLLVTK--------------------------AVKKAERTRVI 683
Query: 292 DQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQI 351
P+ +D++V + + +FL+ + N + + A+ QA + + + W+ I
Sbjct: 684 RPPLLVDKIVCRELRD--------PGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTI 735
Query: 352 TTA 354
A
Sbjct: 736 YNA 738
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 92.8 bits (229), Expect = 5e-19
Identities = 86/358 (24%), Positives = 156/358 (43%), Gaps = 45/358 (12%)
Query: 10 LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69
LQ L++V LF N+ L +T F + + G + AS LD I + + +
Sbjct: 162 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRAS--GQPLDPIGLQSGFL 219
Query: 70 R-GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 127
G + YCL + Y ++ + F +++WCE++++ R + +LL+ P Q
Sbjct: 220 TFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQ 279
Query: 128 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEII- 186
R+T+YPLLL + KRS ++ + + ++ E VE +R + G+V+ + + + I
Sbjct: 280 RITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIG 339
Query: 187 ---VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRF-LDVY 242
V P D ++ P + + + S +R LL EG + + E LDVY
Sbjct: 340 PYEVLEPPSDEVEKNLRPFSTLDLTSPMLG--VASEHTRQLLLEGPVRVKEGREGKLDVY 397
Query: 243 LFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVV 302
LFLF+D LLVTK + ++ V+ P+ L++LV
Sbjct: 398 LFLFSDVLLVTKPQ--------------------------RKADKAKVIRPPLMLEKLVC 431
Query: 303 KSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
+ + N+FL+ H ++ +A L+ + + W+ + A + K
Sbjct: 432 QPLRD--------PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 481
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 92.8 bits (229), Expect = 5e-19
Identities = 86/358 (24%), Positives = 156/358 (43%), Gaps = 45/358 (12%)
Query: 10 LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69
LQ L++V LF N+ L +T F + + G + AS LD I + + +
Sbjct: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRAS--GQPLDPIGLQSGFL 251
Query: 70 R-GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 127
G + YCL + Y ++ + F +++WCE++++ R + +LL+ P Q
Sbjct: 252 TFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQ 311
Query: 128 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEII- 186
R+T+YPLLL + KRS ++ + + ++ E VE +R + G+V+ + + + I
Sbjct: 312 RITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIG 371
Query: 187 ---VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRF-LDVY 242
V P D ++ P + + + S +R LL EG + + E LDVY
Sbjct: 372 PYEVLEPPSDEVEKNLRPFSTLDLTSPMLG--VASEHTRQLLLEGPVRVKEGREGKLDVY 429
Query: 243 LFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVV 302
LFLF+D LLVTK + ++ V+ P+ L++LV
Sbjct: 430 LFLFSDVLLVTKPQ--------------------------RKADKAKVIRPPLMLEKLVC 463
Query: 303 KSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
+ + N+FL+ H ++ +A L+ + + W+ + A + K
Sbjct: 464 QPLRD--------PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 513
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 92.8 bits (229), Expect = 5e-19
Identities = 86/358 (24%), Positives = 156/358 (43%), Gaps = 45/358 (12%)
Query: 10 LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69
LQ L++V LF N+ L +T F + + G + AS LD I + + +
Sbjct: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRAS--GQPLDPIGLQSGFL 251
Query: 70 R-GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 127
G + YCL + Y ++ + F +++WCE++++ R + +LL+ P Q
Sbjct: 252 TFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQ 311
Query: 128 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEII- 186
R+T+YPLLL + KRS ++ + + ++ E VE +R + G+V+ + + + I
Sbjct: 312 RITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIG 371
Query: 187 ---VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRF-LDVY 242
V P D ++ P + + + S +R LL EG + + E LDVY
Sbjct: 372 PYEVLEPPSDEVEKNLRPFSTLDLTSPMLG--VASEHTRQLLLEGPVRVKEGREGKLDVY 429
Query: 243 LFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVV 302
LFLF+D LLVTK + ++ V+ P+ L++LV
Sbjct: 430 LFLFSDVLLVTKPQ--------------------------RKADKAKVIRPPLMLEKLVC 463
Query: 303 KSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
+ + N+FL+ H ++ +A L+ + + W+ + A + K
Sbjct: 464 QPLRD--------PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 513
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 71.6 bits (174), Expect = 1e-12
Identities = 81/359 (22%), Positives = 155/359 (43%), Gaps = 46/359 (12%)
Query: 10 LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69
L E L + ++ +F N +EL ++ + +L K + + D +S +
Sbjct: 1267 LMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHM 1326
Query: 70 RGSLCQSHQTYCLNY-SAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQR 128
Q + +C + A + + DF ++K + +C+ + + ++ P+QR
Sbjct: 1327 -----QPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQR 1381
Query: 129 LTRYPLLLKNIWKRSMDS-AEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIV 187
+TRYPL++KNI + + ++ + + EK E+ + V+ +N + ++Q +
Sbjct: 1382 VTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQ 1441
Query: 188 WPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFN 247
E L + N L P R L+ GKL A+S + ++Y FLFN
Sbjct: 1442 C-------------EGLSEQLVFNSVTNCLGP--RKFLHSGKLYKAKSNK--ELYGFLFN 1484
Query: 248 DFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEP 307
DFLL+T+ K LG S + +P+ K + PI L+ ++VK
Sbjct: 1485 DFLLLTQI---TKPLGSSGTDKV---FSPKSNLQYK------MYKTPIFLNEVLVK---- 1528
Query: 308 LHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTKSQETKK 366
L G F I H +R + L+A++ N + W+ +I A + ++++ K+
Sbjct: 1529 LPTDPSGDEPIFHISHIDR------VYTLRAESINERTAWVQKIKAASELYIETEKKKR 1581
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 67.8 bits (164), Expect = 2e-11
Identities = 69/273 (25%), Positives = 133/273 (48%), Gaps = 24/273 (8%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L RLF NL EL + + ++ + ++ EIS + ++ R L Q
Sbjct: 814 ELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLM--LARFDGPAREELQQVAAQ 871
Query: 80 YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
+C S A+ +++ ++++ F ++++ E + QCRRL + +L+++ +QRLT+YPLLL++
Sbjct: 872 FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 931
Query: 139 IWKRSM-DSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKR 197
I K + ++E + +++ + ++ + VK +N + Q+ + L +R
Sbjct: 932 IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATAL----ER 987
Query: 198 FFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAES-TRFLDVYLFLFNDFLLVTK-- 254
P L FK L T+R +++EG LT S + LD+++ L D L++ +
Sbjct: 988 ASNP--LAAEFKS------LDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQ 1039
Query: 255 -----TKCNKKKLGGSDPGLMCPSLTPELQAVI 282
KC+ K GS S +L AV+
Sbjct: 1040 DEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVL 1072
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 67.8 bits (164), Expect = 2e-11
Identities = 69/273 (25%), Positives = 133/273 (48%), Gaps = 24/273 (8%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L RLF NL EL + + ++ + ++ EIS + ++ R L Q
Sbjct: 774 ELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLM--LARFDGPAREELQQVAAQ 831
Query: 80 YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
+C S A+ +++ ++++ F ++++ E + QCRRL + +L+++ +QRLT+YPLLL++
Sbjct: 832 FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 891
Query: 139 IWKRSM-DSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKR 197
I K + ++E + +++ + ++ + VK +N + Q+ + L +R
Sbjct: 892 IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATAL----ER 947
Query: 198 FFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAES-TRFLDVYLFLFNDFLLVTK-- 254
P L FK L T+R +++EG LT S + LD+++ L D L++ +
Sbjct: 948 ASNP--LAAEFKS------LDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQ 999
Query: 255 -----TKCNKKKLGGSDPGLMCPSLTPELQAVI 282
KC+ K GS S +L AV+
Sbjct: 1000 DEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVL 1032
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 65.9 bits (159), Expect = 6e-11
Identities = 76/352 (21%), Positives = 145/352 (41%), Gaps = 36/352 (10%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L ++F+NLE++ Q +G + + K + D ++ + L + T
Sbjct: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAAT 886
Query: 80 YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
+C N A+ ++S +++D F +++ E N CRRL + +++ +QRLT+YPLLL N
Sbjct: 887 FCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDN 946
Query: 139 IWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKRF 198
I K + E+ + + + + + VK +N Q+ L D +R
Sbjct: 947 IAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQR------------LEDYQRRL 994
Query: 199 FIPECLKHIFKEHMAENILSPTSRHLLYEGKLT-LAESTRFLDVYLFLFNDFLLVTKTKC 257
+ L T R +++EG L + +D+Y L D L++ + +
Sbjct: 995 DTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQD 1054
Query: 258 NKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSVFGLRN 317
++ L C S + + S I L ++V+ + + ++
Sbjct: 1055 DRLV-------LRCHS-----KILASTADSKHTFSPVIKLSTVLVRQVATDNKAL----- 1097
Query: 318 AFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTKSQETKKISL 369
F+I + Q + L AQT + K W + ++ K Q TK I L
Sbjct: 1098 -FVISMSDNGAQ---IYELVAQTVSEKTVWQ-DLICRMAASVKEQSTKPIPL 1144
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/365 (21%), Positives = 146/365 (40%), Gaps = 67/365 (18%)
Query: 15 YLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISV----LTKYFR 70
+L + ++ +F N +EL ++ + +L K + + D ++ + Y R
Sbjct: 1217 FLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIR 1276
Query: 71 GSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLT 130
CQ + A + + DF +LK + +C+ + + L+ P+QR+T
Sbjct: 1277 FCSCQ--------LNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRIT 1328
Query: 131 RYPLLLKNIWKRSMDS-AEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWP 189
RYPLL+++I + + +S A+ + E+ E+ + V+ +N + ++Q
Sbjct: 1329 RYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQ------ 1382
Query: 190 PLWDRDKRFFIPECLKHIFKEHMAE--------NILSPTSRHLLYEGKLTLAESTRFLDV 241
H+ E +AE N L P R LL+ GKL +S + ++
Sbjct: 1383 ---------------AHVQCEGLAEQLIFNSLTNCLGP--RKLLHSGKLYKTKSNK--EL 1423
Query: 242 YLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLV 301
+ FLFNDFLL+T GS E K + PI L+ ++
Sbjct: 1424 HGFLFNDFLLLTYMVKQFAVSSGS-----------EKLFSSKSNAQFKMYKTPIFLNEVL 1472
Query: 302 VKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTKS 361
VK L F I H +R + L+ N + W+ +I A + +
Sbjct: 1473 VK----LPTDPSSDEPVFHISHIDR------VYTLRTDNINERTAWVQKIKAASEQYIDT 1522
Query: 362 QETKK 366
++ K+
Sbjct: 1523 EKKKR 1527
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/365 (21%), Positives = 146/365 (40%), Gaps = 67/365 (18%)
Query: 15 YLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISV----LTKYFR 70
+L + ++ +F N +EL ++ + +L K + + D ++ + Y R
Sbjct: 1244 FLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIR 1303
Query: 71 GSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLT 130
CQ + A + + DF +LK + +C+ + + L+ P+QR+T
Sbjct: 1304 FCSCQ--------LNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRIT 1355
Query: 131 RYPLLLKNIWKRSMDS-AEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWP 189
RYPLL+++I + + +S A+ + E+ E+ + V+ +N + ++Q
Sbjct: 1356 RYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQ------ 1409
Query: 190 PLWDRDKRFFIPECLKHIFKEHMAE--------NILSPTSRHLLYEGKLTLAESTRFLDV 241
H+ E +AE N L P R LL+ GKL +S + ++
Sbjct: 1410 ---------------AHVQCEGLAEQLIFNSLTNCLGP--RKLLHSGKLYKTKSNK--EL 1450
Query: 242 YLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLV 301
+ FLFNDFLL+T GS E K + PI L+ ++
Sbjct: 1451 HGFLFNDFLLLTYMVKQFAVSSGS-----------EKLFSSKSNAQFKMYKTPIFLNEVL 1499
Query: 302 VKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTKS 361
VK L F I H +R + L+ N + W+ +I A + +
Sbjct: 1500 VK----LPTDPSSDEPVFHISHIDR------VYTLRTDNINERTAWVQKIKAASEQYIDT 1549
Query: 362 QETKK 366
++ K+
Sbjct: 1550 EKKKR 1554
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 59.7 bits (143), Expect = 4e-09
Identities = 69/266 (25%), Positives = 114/266 (42%), Gaps = 43/266 (16%)
Query: 13 HEYLLDVD-LWRLFANLEELTQTSLGFV-NSLFGIIKDYVDAS-----------EISSSL 59
H YLL ++ L R+F N +EL+ T + LF I D +AS + + +
Sbjct: 452 HSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFI 511
Query: 60 DFISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRD-DFGIYLKWCEQNEQCRRLHV 118
D IS + + S + YC N L+ L + F L E +E CR L +
Sbjct: 512 DDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPM 571
Query: 119 PELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQK 178
L+ P+QR+TR PLL+ I +++ + K E +++++++ V+ + +
Sbjct: 572 ISFLILPMQRVTRLPLLMDTICQKTPKDSPKY------EVCKRALKEVSKLVRLCNEGAR 625
Query: 179 FRYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLT------- 231
E++ + I L+ K L +SR L+ G+LT
Sbjct: 626 KMERTEMM-----------YTINSQLEFKIKPFP----LVSSSRWLVKRGELTAYVEDTV 670
Query: 232 -LAESTRFLDVYLFLFNDFLLVTKTK 256
+ T VY FLFND L++TK K
Sbjct: 671 LFSRRTSKQQVYFFLFNDVLIITKKK 696
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 57.4 bits (137), Expect = 2e-08
Identities = 55/251 (21%), Positives = 107/251 (42%), Gaps = 33/251 (13%)
Query: 23 RLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFIS-VLTKYFR----GSLCQSH 77
++F L+EL + F S+ ++ S+ + +D I +L + F + + +
Sbjct: 892 KIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIY 951
Query: 78 QTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLK 137
+C ++ A+ + L+Q F ++K N RR +PE ++ QR+T+YP+L++
Sbjct: 952 GEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVE 1011
Query: 138 NIWKRSMDSAEK--------IMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWP 189
I + + + E+ +I + V+ + + E KWL+ K
Sbjct: 1012 RILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKI---------- 1061
Query: 190 PLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAEST-RFLDVYLFLFND 248
+ + + H+F+ + L R LLY+G + +T RF D+ L D
Sbjct: 1062 -----ENKTYTKLKNGHVFR----KQALMSEERTLLYDGLVYWKTATGRFKDILALLLTD 1112
Query: 249 FLLVTKTKCNK 259
LL + K K
Sbjct: 1113 VLLFLQEKDQK 1123
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 53.9 bits (128), Expect = 2e-07
Identities = 73/340 (21%), Positives = 153/340 (45%), Gaps = 46/340 (13%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L +F +L+EL + F++ L +K ++ + + VL F G+ Q
Sbjct: 471 ELQNIFPSLDELIEVHSLFLDRL---MKRRQESGYLIEEIG--DVLLARFDGAEGSWFQK 525
Query: 80 ----YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPL 134
+C S A+ L++ +++D F +++ E +CRRL + +++ +QRLT+YPL
Sbjct: 526 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 585
Query: 135 LLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDR 194
LL++I + + + E+ + E + + + V+ +++ + + D
Sbjct: 586 LLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLK------------DY 633
Query: 195 DKRFFIPECLKHIFKEHMAE-NILSPTSRHLLYEGKLTL-AESTRFLDVYLFLFNDFLLV 252
+R + L+ ++E L T + L++EG LT + ++V++ L +D LL+
Sbjct: 634 QRRLDLSH-LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLL 692
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
+ + +++ L S + P TP+ + T+L + L + + + H +
Sbjct: 693 LQRQ-DERLLLKSHSRTLTP--TPDGK---------TMLRPVLRLTSAMTREVATDHKAF 740
Query: 313 FGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQIT 352
+ L + Q + L AQT + +K W A IT
Sbjct: 741 YVLFT---------WDQEAQIYELVAQTVSERKNWCALIT 771
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 53.9 bits (128), Expect = 2e-07
Identities = 73/340 (21%), Positives = 153/340 (45%), Gaps = 46/340 (13%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L +F +L+EL + F++ L +K ++ + + VL F G+ Q
Sbjct: 423 ELQNIFPSLDELIEVHSLFLDRL---MKRRQESGYLIEEIG--DVLLARFDGAEGSWFQK 477
Query: 80 ----YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPL 134
+C S A+ L++ +++D F +++ E +CRRL + +++ +QRLT+YPL
Sbjct: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
Query: 135 LLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDR 194
LL++I + + + E+ + E + + + V+ +++ + + D
Sbjct: 538 LLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLK------------DY 585
Query: 195 DKRFFIPECLKHIFKEHMAE-NILSPTSRHLLYEGKLTL-AESTRFLDVYLFLFNDFLLV 252
+R + L+ ++E L T + L++EG LT + ++V++ L +D LL+
Sbjct: 586 QRRLDLSH-LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLL 644
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
+ + +++ L S + P TP+ + T+L + L + + + H +
Sbjct: 645 LQRQ-DERLLLKSHSRTLTP--TPDGK---------TMLRPVLRLTSAMTREVATDHKAF 692
Query: 313 FGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQIT 352
+ L + Q + L AQT + +K W A IT
Sbjct: 693 YVLFT---------WDQEAQIYELVAQTVSERKNWCALIT 723
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 53.9 bits (128), Expect = 2e-07
Identities = 73/340 (21%), Positives = 153/340 (45%), Gaps = 46/340 (13%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
+L +F +L+EL + F++ L +K ++ + + VL F G+ Q
Sbjct: 456 ELQNIFPSLDELIEVHSLFLDRL---MKRRQESGYLIEEIG--DVLLARFDGAEGSWFQK 510
Query: 80 ----YCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPL 134
+C S A+ L++ +++D F +++ E +CRRL + +++ +QRLT+YPL
Sbjct: 511 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 570
Query: 135 LLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDR 194
LL++I + + + E+ + E + + + V+ +++ + + D
Sbjct: 571 LLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLK------------DY 618
Query: 195 DKRFFIPECLKHIFKEHMAE-NILSPTSRHLLYEGKLTL-AESTRFLDVYLFLFNDFLLV 252
+R + L+ ++E L T + L++EG LT + ++V++ L +D LL+
Sbjct: 619 QRRLDLSH-LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLL 677
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
+ + +++ L S + P TP+ + T+L + L + + + H +
Sbjct: 678 LQRQ-DERLLLKSHSRTLTP--TPDGK---------TMLRPVLRLTSAMTREVATDHKAF 725
Query: 313 FGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQIT 352
+ L + Q + L AQT + +K W A IT
Sbjct: 726 YVLFT---------WDQEAQIYELVAQTVSERKNWCALIT 756
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 53.9 bits (128), Expect = 2e-07
Identities = 36/153 (23%), Positives = 77/153 (50%), Gaps = 11/153 (7%)
Query: 20 DLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQT 79
DL LF+N++++ + + F++ L AS+ + + + F+ L Q ++
Sbjct: 67 DLDVLFSNIDDIIKVNSRFLHDL------QETASKEEEQVQLVGNIFLEFQEELEQVYKV 120
Query: 80 YCLNYSAAIFYLESLRQRDDFGIYLKWCEQN--EQCRRLHVPELLVAPLQRLTRYPLLLK 137
YC +Y A+ +++ R+ + +++ + Q + LLV PLQR+TRYPLLL+
Sbjct: 121 YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ 180
Query: 138 NIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKV 170
I + ++ A Y + ++ +++D+ +
Sbjct: 181 KILENTVPDAS---AYPVLQRAVSALQDVNTNI 210
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 53.5 bits (127), Expect = 3e-07
Identities = 63/250 (25%), Positives = 104/250 (41%), Gaps = 52/250 (20%)
Query: 24 LFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSL-----DFISVLTKYFRGSLCQSHQ 78
LF+ L+++ S F++ L ++ + + ++ + DF V Y Q
Sbjct: 1218 LFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERT 1277
Query: 79 TYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
L + +F L+ E + C+RL + L+ P QR+TR LLL+N
Sbjct: 1278 FQSL-----------MNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQN 1326
Query: 139 IWKRSM-DSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKR 197
I KR+ S+E+ +E+ IRD V+ + ++ YL + I +
Sbjct: 1327 ILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEF--------- 1377
Query: 198 FFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAE-----------STRFLDVYLFLF 246
EC IF L SR L+ G+LT E +TR V+L LF
Sbjct: 1378 ----EC--KIFP-------LISQSRWLVKSGELTALEFSASPGLRRKLNTR--PVHLHLF 1422
Query: 247 NDFLLVTKTK 256
ND LL+++ +
Sbjct: 1423 NDCLLLSRPR 1432
>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 618
Score = 51.2 bits (121), Expect = 2e-06
Identities = 54/237 (22%), Positives = 106/237 (44%), Gaps = 29/237 (12%)
Query: 24 LFANLEELTQTSLGFVNSLFGIIKDYVDASEISS-----SLDFISVLTKYFRGSLCQSHQ 78
LF+N+ ++ S F+ L +++ + S++ + D SV Y S+Q
Sbjct: 225 LFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV------SNQ 278
Query: 79 TYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
TY Y + L+++ F + E + +CR L L+ P QR+TR LL++N
Sbjct: 279 TY-----QERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQN 333
Query: 139 IWKRSMDSAEK-IMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKR 197
I KR + +E+ +++E ++ V+ + ++ +Q+ + + + K
Sbjct: 334 ILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEF-----KIKS 388
Query: 198 FFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLVTK 254
I + + K+ + + P + L KL F ++YLFLFND L++ +
Sbjct: 389 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKL-------FHEIYLFLFNDLLVICR 438
>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 710
Score = 51.2 bits (121), Expect = 2e-06
Identities = 54/237 (22%), Positives = 106/237 (44%), Gaps = 29/237 (12%)
Query: 24 LFANLEELTQTSLGFVNSLFGIIKDYVDASEISS-----SLDFISVLTKYFRGSLCQSHQ 78
LF+N+ ++ S F+ L +++ + S++ + D SV Y S+Q
Sbjct: 317 LFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV------SNQ 370
Query: 79 TYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN 138
TY Y + L+++ F + E + +CR L L+ P QR+TR LL++N
Sbjct: 371 TY-----QERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQN 425
Query: 139 IWKRSMDSAEK-IMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKR 197
I KR + +E+ +++E ++ V+ + ++ +Q+ + + + K
Sbjct: 426 ILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEF-----KIKS 480
Query: 198 FFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLVTK 254
I + + K+ + + P + L KL F ++YLFLFND L++ +
Sbjct: 481 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKL-------FHEIYLFLFNDLLVICR 530
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 49.7 bits (117), Expect = 4e-06
Identities = 39/154 (25%), Positives = 71/154 (46%), Gaps = 16/154 (10%)
Query: 3 FMNTLRYLQTH------EYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEIS 56
+ +TL +Q H +L D+ +F N+E+L + F +K+ +A
Sbjct: 209 YTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHF-------LKEMKEALGTP 261
Query: 57 SSLDFISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQ-RDDFGIYLKWCEQNEQCRR 115
+ + V KY L YC +A +L+ + R+D + L+ C Q R
Sbjct: 262 GAANLYQVFIKYKERFLVYGR--YCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGR 319
Query: 116 LHVPELLVAPLQRLTRYPLLLKNIWKRSMDSAEK 149
+ +LL+ P+QR+ +Y LLL+ + K + ++ EK
Sbjct: 320 FTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEK 353
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 49.7 bits (117), Expect = 4e-06
Identities = 88/361 (24%), Positives = 152/361 (42%), Gaps = 79/361 (21%)
Query: 3 FMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSS-LDF 61
+M+ LR + L D+ +F NLE+L + F+ ++ + V S ++ LDF
Sbjct: 224 YMSPLRLV-----LSPADMAAVFINLEDLIKVHHSFLRAID--VSVMVGGSTLAKVFLDF 276
Query: 62 ISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPEL 121
L Y G C SH + N + L R+DF ++ C Q + + +L
Sbjct: 277 KERLLIY--GEYC-SHMEHAQNTLNQL-----LASREDFRQKVEECTLKVQDGKFKLQDL 328
Query: 122 LVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRY 181
LV P+QR+ +Y LLLK + S + E+ +KE +E +++DL Y
Sbjct: 329 LVVPMQRVLKYHLLLKELLSHSAERPER---QQLKEALE-AMQDLA------------MY 372
Query: 182 LQEIIVWPPLWDRDKRFFIPECLKHIFK-EHMAENI---LSPTSRHLLYEGKLTLAESTR 237
+ E+ RDK E L+ I + + EN+ L R + +G+L +
Sbjct: 373 INEV-------KRDK-----ETLRKISEFQSSIENLQVKLEEFGRPKI-DGELKVRSIVN 419
Query: 238 FL--DVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPI 295
D YLFLF+ ++V K K + EL+ +I+ +L +
Sbjct: 420 HTKQDRYLFLFDKVVIVCKRK----------------GYSYELKEIIE------LLFHKM 457
Query: 296 PLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAI 355
D + K ++ H ++ +LI + + F +TE++K+ WM Q A+
Sbjct: 458 TDDPMNNKDVKKSHGKMWSY-GFYLIHLQGK-----QGFQFFCKTEDMKRKWMEQFEMAM 511
Query: 356 S 356
S
Sbjct: 512 S 512
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/241 (25%), Positives = 96/241 (39%), Gaps = 35/241 (14%)
Query: 24 LFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQTYCLN 83
LF+N+ ++ S F L K V +IS L+ K+F + YC N
Sbjct: 328 LFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILE--EHAEKHFHPYIA-----YCSN 380
Query: 84 YSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKNIWKR 142
L+ L + F L+ E+ C L + L+ P+QR+TR PLL+ + +
Sbjct: 381 EVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLK 440
Query: 143 SMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKRFFIPE 202
+ +E+ Y + K+I L + + + ++++ D K +P
Sbjct: 441 TQGHSER---YKAASRALKAISKLVRQCN--EGAHRMERMEQMYTLHTQLDFSKVKSLP- 494
Query: 203 CLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFL-------DVYLFLFNDFLLVTKT 255
L SR LL G+L L E T YLFLFND L+VTK
Sbjct: 495 --------------LISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKK 540
Query: 256 K 256
K
Sbjct: 541 K 541
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/296 (21%), Positives = 127/296 (42%), Gaps = 62/296 (20%)
Query: 76 SHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLL 135
S+ +YC N AA L+ +Q +L+ C ++ R+L + L P RL +YPLL
Sbjct: 216 SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL 275
Query: 136 LKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLD---NFQKFRYLQEIIVWPPLW 192
L+ I + + + ++ +E++I ++G V ++ + RY +E
Sbjct: 276 LREILRHTPNDNPD------QQHLEEAINIIQGIVAEINTKTGESECRYYKE-------- 321
Query: 193 DRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLV 252
+ ++ E ++ L +SR L G+L ++ R + +++FLF + L++
Sbjct: 322 ------------RLLYLEEGQKDSLIDSSRVLCCHGEL---KNNRGVKLHVFLFQEVLVI 366
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
T+ + ++L C L QPIP+ L+++ ++ V +
Sbjct: 367 TRAVTHNEQL--------CYQL----------------YRQPIPVKDLLLEDLQDGEVRL 402
Query: 313 FG-LRNAFLIQHENRYRQCIAAFL---LQAQTENIKKTWMAQITTAISCFTKSQET 364
G LR AF + R + Q+QT +++ ++C +++ET
Sbjct: 403 GGSLRGAF--SNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKET 456
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/296 (21%), Positives = 127/296 (42%), Gaps = 62/296 (20%)
Query: 76 SHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLL 135
S+ +YC N AA L+ +Q +L+ C ++ R+L + L P RL +YPLL
Sbjct: 242 SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL 301
Query: 136 LKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLD---NFQKFRYLQEIIVWPPLW 192
L+ I + + + ++ +E++I ++G V ++ + RY +E
Sbjct: 302 LREILRHTPNDNPD------QQHLEEAINIIQGIVAEINTKTGESECRYYKE-------- 347
Query: 193 DRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLV 252
+ ++ E ++ L +SR L G+L ++ R + +++FLF + L++
Sbjct: 348 ------------RLLYLEEGQKDSLIDSSRVLCCHGEL---KNNRGVKLHVFLFQEVLVI 392
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
T+ + ++L C L QPIP+ L+++ ++ V +
Sbjct: 393 TRAVTHNEQL--------CYQL----------------YRQPIPVKDLLLEDLQDGEVRL 428
Query: 313 FG-LRNAFLIQHENRYRQCIAAFL---LQAQTENIKKTWMAQITTAISCFTKSQET 364
G LR AF + R + Q+QT +++ ++C +++ET
Sbjct: 429 GGSLRGAF--SNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKET 482
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 48.1 bits (113), Expect = 1e-05
Identities = 63/296 (21%), Positives = 127/296 (42%), Gaps = 62/296 (20%)
Query: 76 SHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLL 135
S+ +YC N AA L+ +Q +L+ C ++ R+L + L P RL +YPLL
Sbjct: 210 SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL 269
Query: 136 LKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLD---NFQKFRYLQEIIVWPPLW 192
L+ I + + + ++ +E++I ++G V ++ + RY +E
Sbjct: 270 LREILRHTPNDNPD------QQHLEEAINIIQGIVAEINTKTGESECRYYKE-------- 315
Query: 193 DRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLV 252
+ ++ E ++ L +SR L G+L ++ R + +++FLF + L++
Sbjct: 316 ------------RLLYLEEGQKDSLIDSSRVLCCHGEL---KNNRGVKLHVFLFQEVLVI 360
Query: 253 TKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV 312
T+ + ++L C L QPIP+ L+++ ++ V +
Sbjct: 361 TRAVTHNEQL--------CYQL----------------YRQPIPVKDLLLEDLQDGEVRL 396
Query: 313 FG-LRNAFLIQHENRYRQCIAAFL---LQAQTENIKKTWMAQITTAISCFTKSQET 364
G LR AF + R + Q+QT +++ ++C +++ET
Sbjct: 397 GGSLRGAF--SNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKET 450
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,596,011
Number of Sequences: 37866
Number of extensions: 576960
Number of successful extensions: 1909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 1750
Number of HSP's gapped (non-prelim): 141
length of query: 379
length of database: 18,247,518
effective HSP length: 104
effective length of query: 275
effective length of database: 14,309,454
effective search space: 3935099850
effective search space used: 3935099850
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.