Search of human proteins with 133908623

Search of human proteins with 133908623

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|133908623 protein kinase C, iota [Homo sapiens]
         (596 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|133908623 protein kinase C, iota [Homo sapiens]                   1239   0.0  
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           876   0.0  
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           628   e-180
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           628   e-180
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   407   e-113
gi|28557781 protein kinase C, eta [Homo sapiens]                      392   e-109
gi|4506067 protein kinase C, alpha [Homo sapiens]                     373   e-103
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           369   e-102
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           367   e-101
gi|13384594 protein kinase C, gamma [Homo sapiens]                    350   2e-96
gi|47157325 protein kinase C, delta [Homo sapiens]                    341   1e-93
gi|31377782 protein kinase C, delta [Homo sapiens]                    341   1e-93
gi|5453976 protein kinase C, theta [Homo sapiens]                     336   3e-92
gi|4502023 AKT2 kinase [Homo sapiens]                                 325   6e-89
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       313   2e-85
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      313   2e-85
gi|62241015 AKT1 kinase [Homo sapiens]                                313   3e-85
gi|62241013 AKT1 kinase [Homo sapiens]                                313   3e-85
gi|62241011 AKT1 kinase [Homo sapiens]                                313   3e-85
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   304   1e-82
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   304   1e-82
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   303   3e-82
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   302   5e-82
gi|5453974 protein kinase N2 [Homo sapiens]                           300   3e-81
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   294   2e-79
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   294   2e-79
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   294   2e-79
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   294   2e-79
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                277   2e-74
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                277   2e-74

>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score = 1239 bits (3205), Expect = 0.0
 Identities = 596/596 (100%), Positives = 596/596 (100%)

Query: 1   MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 60
           MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
Sbjct: 1   MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 60

Query: 61  DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 120
           DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
Sbjct: 61  DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 120

Query: 121 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 180
           DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
Sbjct: 121 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 180

Query: 181 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 240
           KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
Sbjct: 181 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 240

Query: 241 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 300
           ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
Sbjct: 241 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 300

Query: 301 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 360
           TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
Sbjct: 301 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 360

Query: 361 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 420
           EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
Sbjct: 361 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 420

Query: 421 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 480
           APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
Sbjct: 421 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 480

Query: 481 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 540
           IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
Sbjct: 481 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 540

Query: 541 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
           PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
Sbjct: 541 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  876 bits (2264), Expect = 0.0
 Identities = 429/589 (72%), Positives = 493/589 (83%), Gaps = 17/589 (2%)

Query: 18  GSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDP 77
           GSG    +VR+KA+Y GDI IT  + + +FE LC EVRDMC    +   T+KW+D EGDP
Sbjct: 11  GSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDP 67

Query: 78  CTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYC 137
           CTVSSQ+ELEEAFRL    +D  L+IHVFP  PE+PG+PCPGEDKSIYRRGARRWRKLY 
Sbjct: 68  CTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYR 127

Query: 138 ANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS--- 194
           ANGH FQAKRFNRRA+C  C++RIWGL RQGY+CINCKLLVHK+CH LV + C +H    
Sbjct: 128 ANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSV 187

Query: 195 LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASS 247
           +P QEP  P+D  +  +D        I Y  SS  H+S+    E+ K  ++  +  K S 
Sbjct: 188 MPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQ 245

Query: 248 SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 307
            LGLQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFE
Sbjct: 246 GLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFE 305

Query: 308 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 367
           QAS++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN
Sbjct: 306 QASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALN 365

Query: 368 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 427
           +LHERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRG
Sbjct: 366 FLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRG 425

Query: 428 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 487
           E+YGFSVDWWALGVLMFEMMAGRSPFDI+  +DNPD NTEDYLFQVILEK IRIPR LSV
Sbjct: 426 EEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSV 483

Query: 488 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEF 547
           KA+ VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++
Sbjct: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543

Query: 548 GLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
           GLDNFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  628 bits (1620), Expect = e-180
 Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)

Query: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250
           QEP  P+D  +  +D        I Y  SS  H+S+    E+ K  ++  +  K S  LG
Sbjct: 8   QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65

Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
           LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
           ++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
           ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
           GFSVDWWALGVLMFEMMAGRSPFDI+  +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
            VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363

Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
           NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  628 bits (1620), Expect = e-180
 Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)

Query: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250
           QEP  P+D  +  +D        I Y  SS  H+S+    E+ K  ++  +  K S  LG
Sbjct: 8   QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65

Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
           LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
           ++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
           ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
           GFSVDWWALGVLMFEMMAGRSPFDI+  +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
            VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363

Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
           NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  407 bits (1047), Expect = e-113
 Identities = 222/503 (44%), Positives = 298/503 (59%), Gaps = 62/503 (12%)

Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG--------- 191
           H F    +     C  C   +WGL RQG +C  CK+ VH++C   V   CG         
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302

Query: 192 -----------------RHSL--PQEPVMPMDQSSMHSDHAQTVIPYNPSSHE------- 225
                            R  L    E   P   SS   +      P +P   E       
Sbjct: 303 LADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENN 362

Query: 226 -----SLDQVGEEKEA--------MNTRESGKA----SSSLGLQDFDLLRVIGRGSYAKV 268
                S D  GEE  A        M+  E+G+     +  LGL +F+ ++V+G+GS+ KV
Sbjct: 363 IRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKV 422

Query: 269 LLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRL 328
           +L  LK  D +YA+KV+KK+++  D+D+D   TEK +   A  HP+L  L+ CFQT+ RL
Sbjct: 423 MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482

Query: 329 FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDS 388
           FFV+EYVNGGDLMF +QR RK  E  +RFY+AE++ AL +LH+ G+IYRDLKLDN+LLD+
Sbjct: 483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA 542

Query: 389 EGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA 448
           EGH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  +YG SVDWWALGVLM+EMMA
Sbjct: 543 EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 602

Query: 449 GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC- 507
           G+ PF+    +DN     ED LF+ IL   +  P  LS +A S+LK+F+ K+P +RLGC 
Sbjct: 603 GQPPFE----ADN-----EDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCV 653

Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
             Q G   I+ HPFF+ +DW ++EQK++ PPFKP I  +  ++NFD  FT E   LT  D
Sbjct: 654 ASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVD 713

Query: 568 DDIVRKIDQSEFEGFEYINPLLM 590
           + IV++I+Q EF+GF Y    LM
Sbjct: 714 EAIVKQINQEEFKGFSYFGEDLM 736



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 29/66 (43%), Positives = 44/66 (66%), Gaps = 2/66 (3%)

Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWG-LGRQGYKCINCKLLVHKKCHK 184
           R+GA R R+++  NGH F A    +  +C+ C D IWG +G+QGY+C  C  +VHK+CH+
Sbjct: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214

Query: 185 LVTIEC 190
           L+  +C
Sbjct: 215 LIITKC 220


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  392 bits (1006), Expect = e-109
 Identities = 197/449 (43%), Positives = 272/449 (60%), Gaps = 13/449 (2%)

Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200
           H F    +     C  C   +WG+ RQG +C  CK+ VH +C   V   CG +++     
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKT 305

Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
           +    + M              S  +L + G+E           +S+ LG+ +F+ +RV+
Sbjct: 306 L----AGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVL 361

Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
           G+GS+ KV+L R+K+T  +YA+KV+KK+++  D+D++   TEK +   A NHPFL  L  
Sbjct: 362 GKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFC 421

Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
           CFQT  RLFFV+E+VNGGDLMFH+Q+ R+  E  ARFY+AEI  AL +LH++GIIYRDLK
Sbjct: 422 CFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLK 481

Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
           LDNVLLD EGH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+   YG +VDWWA+G
Sbjct: 482 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMG 541

Query: 441 VLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKD 500
           VL++EM+ G +PF         +   ED LF+ IL  ++  P  L   A  +LKSF+ K+
Sbjct: 542 VLLYEMLCGHAPF---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKN 592

Query: 501 PKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEP 560
           P  RLG   Q G   I  HPFF+ +DW  +  +Q+ PPF+P I     + NFD  F  E 
Sbjct: 593 PTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 652

Query: 561 VQLTPDDDDIVRKIDQSEFEGFEYINPLL 589
             LTP D+  +  I+Q EF  F Y++P L
Sbjct: 653 PVLTPIDEGHLPMINQDEFRNFSYVSPEL 681



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 1/59 (1%)

Query: 133 RKLYCANGHTFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTIEC 190
           R+++  NGH F A    +  +C+ C + IWG+ G+QGY+C  C  +VHK+CH L+   C
Sbjct: 164 RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTAC 222


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  373 bits (957), Expect = e-103
 Identities = 182/367 (49%), Positives = 247/367 (67%), Gaps = 17/367 (4%)

Query: 221 PSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY 280
           P+ ++ +    + K+  N  +  K      L DF+ L V+G+GS+ KV+L   K T+ +Y
Sbjct: 312 PAGNKVISPSEDRKQPSNNLDRVK------LTDFNFLMVLGKGSFGKVMLADRKGTEELY 365

Query: 281 AMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDL 340
           A+K++KK++V  D+D++    EK V       PFL  LHSCFQT  RL+FV+EYVNGGDL
Sbjct: 366 AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL 425

Query: 341 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMC 400
           M+H+Q+  K  E  A FY+AEIS+ L +LH+RGIIYRDLKLDNV+LDSEGHIK+ D+GMC
Sbjct: 426 MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC 485

Query: 401 KEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSD 460
           KE +  G TT TFCGTP+YIAPEI+  + YG SVDWWA GVL++EM+AG+ PF       
Sbjct: 486 KEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF------- 538

Query: 461 NPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
             D   ED LFQ I+E  +  P+SLS +A S+ K  + K P +RLGC P+ G  D++ H 
Sbjct: 539 --DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHA 595

Query: 521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 580
           FFR +DW+ +E +++ PPFKP + G+ G +NFD  FT     LTP D  ++  IDQS+FE
Sbjct: 596 FFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFE 654

Query: 581 GFEYINP 587
           GF Y+NP
Sbjct: 655 GFSYVNP 661



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 28/65 (43%), Positives = 41/65 (63%)

Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
           R+GA R + ++    H F A+ F +   C+ CTD IWG G+QG++C  C  +VHK+CH+ 
Sbjct: 22  RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81

Query: 186 VTIEC 190
           VT  C
Sbjct: 82  VTFSC 86



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 8/75 (10%)

Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
           CPG DK       R        + H F+   +     C  C   ++GL  QG KC  C +
Sbjct: 86  CPGADKGPDTDDPR--------SKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137

Query: 177 LVHKKCHKLVTIECG 191
            VHK+C   V   CG
Sbjct: 138 NVHKQCVINVPSLCG 152


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  369 bits (947), Expect = e-102
 Identities = 175/343 (51%), Positives = 238/343 (69%), Gaps = 11/343 (3%)

Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
           L DF+ L V+G+GS+ KV+L   K TD +YA+K++KK++V  D+D++    EK V     
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398

Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
             PFL  LHSCFQT  RL+FV+EYVNGGDLM+H+Q+  +  E HA FY+AEI++ L +L 
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
            +GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518

Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
           G SVDWWA GVL++EM+AG++PF         +   ED LFQ I+E  +  P+S+S +A 
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPKSMSKEAV 569

Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
           ++ K  + K P +RLGC P+ G  DI+ H FFR +DW+ +E+K++ PP+KP   G    +
Sbjct: 570 AICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAE 627

Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAE 593
           NFD  FT  P  LTP D +++R IDQSEFEGF ++N   +  E
Sbjct: 628 NFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)

Query: 116 PCPGEDKSIY--RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCIN 173
           P  GE+ ++   R+GA R + ++    H F A+ F +   C+ CTD IWG G+QG++C  
Sbjct: 10  PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69

Query: 174 CKLLVHKKCHKLVTIEC 190
           C  +VHK+CH+ VT  C
Sbjct: 70  CCFVVHKRCHEFVTFSC 86



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 8/75 (10%)

Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
           CPG DK       R        + H F+   ++    C  C   ++GL  QG KC  C +
Sbjct: 86  CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137

Query: 177 LVHKKCHKLVTIECG 191
            VHK+C   V   CG
Sbjct: 138 NVHKRCVMNVPSLCG 152


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  367 bits (943), Expect = e-101
 Identities = 172/337 (51%), Positives = 235/337 (69%), Gaps = 10/337 (2%)

Query: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
           L DF+ L V+G+GS+ KV+L   K TD +YA+K++KK++V  D+D++    EK V     
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398

Query: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
             PFL  LHSCFQT  RL+FV+EYVNGGDLM+H+Q+  +  E HA FY+AEI++ L +L 
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

Query: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
            +GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518

Query: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
           G SVDWWA GVL++EM+AG++PF         +   ED LFQ I+E  +  P+S+S +A 
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPKSMSKEAV 569

Query: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
           ++ K  + K P +RLGC P+ G  DI+ H FFR +DW+ +E+K++ PP+KP    +    
Sbjct: 570 AICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS 628

Query: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
           NFD +FT +PV+LTP D   +  +DQ+EF GF Y NP
Sbjct: 629 NFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)

Query: 116 PCPGEDKSIY--RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCIN 173
           P  GE+ ++   R+GA R + ++    H F A+ F +   C+ CTD IWG G+QG++C  
Sbjct: 10  PSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQV 69

Query: 174 CKLLVHKKCHKLVTIEC 190
           C  +VHK+CH+ VT  C
Sbjct: 70  CCFVVHKRCHEFVTFSC 86



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 8/75 (10%)

Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
           CPG DK       R        + H F+   ++    C  C   ++GL  QG KC  C +
Sbjct: 86  CPGADKGPASDDPR--------SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMM 137

Query: 177 LVHKKCHKLVTIECG 191
            VHK+C   V   CG
Sbjct: 138 NVHKRCVMNVPSLCG 152


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  350 bits (898), Expect = 2e-96
 Identities = 171/350 (48%), Positives = 235/350 (67%), Gaps = 16/350 (4%)

Query: 243 GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTE 302
           G +   L + DF  L V+G+GS+ KV+L   + +D +YA+K++KK+++  D+D+D    E
Sbjct: 340 GASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVE 399

Query: 303 KHVFEQASNHP-----FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARF 357
           K V       P     FL  LHS FQT  RL+FV+EYV GGDLM+H+Q+  K  E HA F
Sbjct: 400 KRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAF 459

Query: 358 YSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP 417
           Y+AEI++ L +LH +GIIYRDLKLDNV+LD+EGHIK+TD+GMCKE + PG TT TFCGTP
Sbjct: 460 YAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTP 519

Query: 418 NYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 477
           +YIAPEI+  + YG SVDWW+ GVL++EM+AG+ PF         D   E+ LFQ I+E+
Sbjct: 520 DYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF---------DGEDEEELFQAIMEQ 570

Query: 478 QIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVP 537
            +  P+SLS +A ++ K FL K P +RLG  P  G   I+ H FFR +DW+ +E+ ++ P
Sbjct: 571 TVTYPKSLSREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPP 629

Query: 538 PFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
           PF+P   G  G +NFD  FT     LTP D  ++  IDQ++F+GF Y+NP
Sbjct: 630 PFRPRPCGRSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)

Query: 107 PCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGR 166
           P V +  G P P       R+GA R + ++    H F A+ F +   C+ CTD IWG+G+
Sbjct: 6   PGVGDSEGGPRP----LFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGK 61

Query: 167 QGYKCINCKLLVHKKCHKLVTIEC 190
           QG +C  C  +VH++CH+ VT EC
Sbjct: 62  QGLQCQVCSFVVHRRCHEFVTFEC 85



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 15/113 (13%)

Query: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
           CPG  K       R        N H F+   ++    C  C   ++GL  QG KC  C++
Sbjct: 85  CPGAGKGPQTDDPR--------NKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEM 136

Query: 177 LVHKKCHKLVTIECG------RHSLPQEPVMP-MDQSSMHSDHAQTVIPYNPS 222
            VH++C + V   CG      R  L  E   P  D+  +    A+ +IP +P+
Sbjct: 137 NVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPN 189


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  341 bits (874), Expect = 1e-93
 Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)

Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199
           H F+   +     C  C   +WGL +QG KC +C + VH KC + V   CG    L  E 
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290

Query: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255
           +  + Q +S  SD A +         E    V  E    N+   GK    SS   + +F 
Sbjct: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350

Query: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315
             +V+G+GS+ KVLL  LK     +A+K +KK++V  D+D++    EK V   A+ +PFL
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410

Query: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375
             L   FQT+  LFFV+E++NGGDLM+H+Q + +     A FY+AEI   L +LH +GII
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470

Query: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435
           YRDLKLDNVLLD +GHIK+ D+GMCKE +      STFCGTP+YIAPEIL+G  Y FSVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530

Query: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495
           WW+ GVL++EM+ G+SPF           + ED LF+ I       PR ++ ++  +L+ 
Sbjct: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581

Query: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555
              ++P +RLG    TG  +I+ HPFF+ ++W ++E++++ PPF+P +       NFD +
Sbjct: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636

Query: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
           F NE  +L+  D +++  +DQS F GF ++NP
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 26/65 (40%), Positives = 36/65 (55%)

Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
           RRGA +  K++    H F A  F +   C++C D +WGL +QGYKC  C   +HKKC   
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203

Query: 186 VTIEC 190
           +   C
Sbjct: 204 IIGRC 208


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  341 bits (874), Expect = 1e-93
 Identities = 182/452 (40%), Positives = 265/452 (58%), Gaps = 19/452 (4%)

Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG-RHSLPQEP 199
           H F+   +     C  C   +WGL +QG KC +C + VH KC + V   CG    L  E 
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEA 290

Query: 200 VMPMDQ-SSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGK---ASSSLGLQDFD 255
           +  + Q +S  SD A +         E    V  E    N+   GK    SS   + +F 
Sbjct: 291 LNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFI 350

Query: 256 LLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 315
             +V+G+GS+ KVLL  LK     +A+K +KK++V  D+D++    EK V   A+ +PFL
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410

Query: 316 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 375
             L   FQT+  LFFV+E++NGGDLM+H+Q + +     A FY+AEI   L +LH +GII
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470

Query: 376 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 435
           YRDLKLDNVLLD +GHIK+ D+GMCKE +      STFCGTP+YIAPEIL+G  Y FSVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530

Query: 436 WWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKS 495
           WW+ GVL++EM+ G+SPF           + ED LF+ I       PR ++ ++  +L+ 
Sbjct: 531 WWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDILEK 581

Query: 496 FLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555
              ++P +RLG    TG  +I+ HPFF+ ++W ++E++++ PPF+P +       NFD +
Sbjct: 582 LFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQE 636

Query: 556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
           F NE  +L+  D +++  +DQS F GF ++NP
Sbjct: 637 FLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 26/65 (40%), Positives = 36/65 (55%)

Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
           RRGA +  K++    H F A  F +   C++C D +WGL +QGYKC  C   +HKKC   
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203

Query: 186 VTIEC 190
           +   C
Sbjct: 204 IIGRC 208


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  336 bits (862), Expect = 3e-92
 Identities = 177/482 (36%), Positives = 259/482 (53%), Gaps = 49/482 (10%)

Query: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200
           H F+   +     C  C   +WGL RQG KC  C + VH +C   V   CG +       
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEA 291

Query: 201 MPMDQSSMHS------------------------DHAQTVIPYNPSSHE----------- 225
           + M +S+  +                        + A+      P   E           
Sbjct: 292 LAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLD 351

Query: 226 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 285
            +D++    E    +E       L ++DF L +++G+GS+ KV L   KKT++ +A+K +
Sbjct: 352 EVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKAL 411

Query: 286 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 345
           KK++V  D+D++    EK V   A  HPFL  +   FQT+  LFFV+EY+NGGDLM+H+Q
Sbjct: 412 KKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ 471

Query: 346 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR 405
              K     A FY+AEI L L +LH +GI+YRDLKLDN+LLD +GHIK+ D+GMCKE + 
Sbjct: 472 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML 531

Query: 406 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQN 465
               T+TFCGTP+YIAPEIL G+ Y  SVDWW+ GVL++EM+ G+SPF            
Sbjct: 532 GDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF---------HGQ 582

Query: 466 TEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 525
            E+ LF  I       PR L  +A  +L     ++P++RLG        DI+ HP FR +
Sbjct: 583 DEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFREI 637

Query: 526 DWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585
           +W+ +E+K++ PPF+P +   F   NFD +F NE  +L+  D  ++  +DQ+ F  F ++
Sbjct: 638 NWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFM 697

Query: 586 NP 587
           NP
Sbjct: 698 NP 699



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 25/65 (38%), Positives = 37/65 (56%)

Query: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
           RRGA +  K++    H F A  F +   C++C + +WGL +QGY+C  C   +HKKC   
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204

Query: 186 VTIEC 190
           V  +C
Sbjct: 205 VIAKC 209


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  325 bits (834), Expect = 6e-89
 Identities = 165/362 (45%), Positives = 235/362 (64%), Gaps = 19/362 (5%)

Query: 231 GEEKEAMNTRES----GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVK 286
           G   ++  T E      KA + + + DFD L+++G+G++ KV+LVR K T R YAMK+++
Sbjct: 125 GSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILR 184

Query: 287 KELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR 346
           KE++   +++    TE  V  Q + HPFL  L   FQT  RL FV+EY NGG+L FH+ R
Sbjct: 185 KEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243

Query: 347 QRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP 406
           +R   EE ARFY AEI  AL YLH R ++YRD+KL+N++LD +GHIK+TD+G+CKEG+  
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303

Query: 407 GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT 466
           G T  TFCGTP Y+APE+L   DYG +VDWW LGV+M+EMM GR PF       N D   
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD--- 354

Query: 467 EDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVD 526
            + LF++IL ++IR PR+LS +A S+L   L KDPK+RLG  P     ++  H FF +++
Sbjct: 355 HERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSIN 413

Query: 527 WDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD--DDI-VRKIDQ-SEFEGF 582
           W  + QK+++PPFKP ++ E     FD +FT + + +TP D  D + + ++DQ + F  F
Sbjct: 414 WQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQF 473

Query: 583 EY 584
            Y
Sbjct: 474 SY 475


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  313 bits (803), Expect = 2e-85
 Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)

Query: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278
           N S    +D +GEE+ +A  T    K      + DFD L+++G+G++ KV+LVR K + +
Sbjct: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172

Query: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338
            YAMK++KKE++   +++    TE  V +  + HPFL  L   FQT+ RL FV+EYVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231

Query: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398
           +L FH+ R+R   E+  RFY AEI  AL+YLH   I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291

Query: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458
           +CKEG+    T  TFCGTP Y+APE+L   DYG +VDWW LGV+M+EMM GR PF     
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346

Query: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518
             N D    + LF++IL + I+ PR+LS  A S+L   L KDP +RLG  P     +I  
Sbjct: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401

Query: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
           H FF  V+W  +  K++VPPFKP ++ E     FD +FT + + +TP +
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  313 bits (803), Expect = 2e-85
 Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)

Query: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278
           N S    +D +GEE+ +A  T    K      + DFD L+++G+G++ KV+LVR K + +
Sbjct: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172

Query: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338
            YAMK++KKE++   +++    TE  V +  + HPFL  L   FQT+ RL FV+EYVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231

Query: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398
           +L FH+ R+R   E+  RFY AEI  AL+YLH   I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291

Query: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458
           +CKEG+    T  TFCGTP Y+APE+L   DYG +VDWW LGV+M+EMM GR PF     
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346

Query: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518
             N D    + LF++IL + I+ PR+LS  A S+L   L KDP +RLG  P     +I  
Sbjct: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401

Query: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
           H FF  V+W  +  K++VPPFKP ++ E     FD +FT + + +TP +
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  313 bits (802), Expect = 3e-85
 Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)

Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
           K    + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++   +++    TE 
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199

Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
            V  Q S HPFL  L   FQT  RL FV+EY NGG+L FH+ R+R   E+ ARFY AEI 
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258

Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
            AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T  TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318

Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
           E+L   DYG +VDWW LGV+M+EMM GR PF       N D    + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369

Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
           R+L  +A S+L   L KDPK+RLG   +    +I  H FF  + W  + +K++ PPFKP 
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428

Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
           ++ E     FD +FT + + +T PD DD +  +D   +  F  F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  313 bits (802), Expect = 3e-85
 Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)

Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
           K    + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++   +++    TE 
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199

Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
            V  Q S HPFL  L   FQT  RL FV+EY NGG+L FH+ R+R   E+ ARFY AEI 
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258

Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
            AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T  TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318

Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
           E+L   DYG +VDWW LGV+M+EMM GR PF       N D    + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369

Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
           R+L  +A S+L   L KDPK+RLG   +    +I  H FF  + W  + +K++ PPFKP 
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428

Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
           ++ E     FD +FT + + +T PD DD +  +D   +  F  F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  313 bits (802), Expect = 3e-85
 Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)

Query: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303
           K    + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++   +++    TE 
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199

Query: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363
            V  Q S HPFL  L   FQT  RL FV+EY NGG+L FH+ R+R   E+ ARFY AEI 
Sbjct: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258

Query: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422
            AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T  TFCGTP Y+AP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318

Query: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
           E+L   DYG +VDWW LGV+M+EMM GR PF       N D    + LF++IL ++IR P
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369

Query: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
           R+L  +A S+L   L KDPK+RLG   +    +I  H FF  + W  + +K++ PPFKP 
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428

Query: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584
           ++ E     FD +FT + + +T PD DD +  +D   +  F  F Y
Sbjct: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  304 bits (779), Expect = 1e-82
 Identities = 163/396 (41%), Positives = 233/396 (58%), Gaps = 31/396 (7%)

Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
           + MD     SD      P       S  ++    + +N   SG   +     DFD L+VI
Sbjct: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168

Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
           G+GS+ KVLL + K   + YA+KV++K++V + ++   +  E++V  +   HPFLVGLH 
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228

Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
            FQT  +L+FV+++VNGG+L FH+QR+R  PE  ARFY+AEI+ AL YLH   I+YRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288

Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
            +N+LLDS GH+ LTD+G+CKEG+   DTT+TFCGTP Y+APE++R + Y  +VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348

Query: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
            +++EM+ G  PF   D+    DN            IL K + +   +S+ A S+L+  L
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 396

Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
            KD + RLG   +  F +IQ HPFF ++ W  + QK++ PPF PN++G   + NFD+ FT
Sbjct: 397 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454

Query: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
            E V  +     D  IV          F GF Y  P
Sbjct: 455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  304 bits (779), Expect = 1e-82
 Identities = 163/396 (41%), Positives = 233/396 (58%), Gaps = 31/396 (7%)

Query: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
           + MD     SD      P       S  ++    + +N   SG   +     DFD L+VI
Sbjct: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168

Query: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
           G+GS+ KVLL + K   + YA+KV++K++V + ++   +  E++V  +   HPFLVGLH 
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228

Query: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
            FQT  +L+FV+++VNGG+L FH+QR+R  PE  ARFY+AEI+ AL YLH   I+YRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288

Query: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
            +N+LLDS GH+ LTD+G+CKEG+   DTT+TFCGTP Y+APE++R + Y  +VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348

Query: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
            +++EM+ G  PF   D+    DN            IL K + +   +S+ A S+L+  L
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 396

Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
            KD + RLG   +  F +IQ HPFF ++ W  + QK++ PPF PN++G   + NFD+ FT
Sbjct: 397 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454

Query: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
            E V  +     D  IV          F GF Y  P
Sbjct: 455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  303 bits (776), Expect = 3e-82
 Identities = 160/376 (42%), Positives = 230/376 (61%), Gaps = 27/376 (7%)

Query: 195 LPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDF 254
           LP  P +P     M+S  A T  P  PS       +G             A+ +    DF
Sbjct: 48  LPVPPELPDHCYRMNSSPAGTPSP-QPSRANGNINLGPS-----------ANPNAQPTDF 95

Query: 255 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF 314
           D L+VIG+G+Y KVLL + K     YA+KV++K+ +   ++   +  E+ V  +   HPF
Sbjct: 96  DFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPF 155

Query: 315 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI 374
           LVGL   FQT  +L+FV++YVNGG+L FH+QR+R+  E  ARFY+AE++ A+ YLH   I
Sbjct: 156 LVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNI 215

Query: 375 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 434
           IYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y  +V
Sbjct: 216 IYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAV 275

Query: 435 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK 494
           DWW LG +++EM+ G  PF     S +  Q     +++ IL + ++IP   +V A  +L+
Sbjct: 276 DWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDLLQ 326

Query: 495 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS 554
           S L+KD ++RLG   +  F +I+ H FF  ++WD +  K++ PPF PN++G   L +FD 
Sbjct: 327 SLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384

Query: 555 QFTNEPVQ----LTPD 566
           +FT E V      TPD
Sbjct: 385 EFTQEAVSKSIGCTPD 400


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  302 bits (774), Expect = 5e-82
 Identities = 147/318 (46%), Positives = 212/318 (66%), Gaps = 15/318 (4%)

Query: 253 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 312
           DFD L+VIG+G+Y KVLL + K     YA+KV++K+ +   ++   +  E+ V  +   H
Sbjct: 34  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93

Query: 313 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 372
           PFLVGL   FQT  +L+FV++YVNGG+L FH+QR+R+  E  ARFY+AE++ A+ YLH  
Sbjct: 94  PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153

Query: 373 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGF 432
            IIYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y  
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213

Query: 433 SVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASV 492
           +VDWW LG +++EM+ G  PF     S +  Q     +++ IL + ++IP   +V A  +
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDL 264

Query: 493 LKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNF 552
           L+S L+KD ++RLG   +  F +I+ H FF  ++WD +  K++ PPF PN++G   L +F
Sbjct: 265 LQSLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 322

Query: 553 DSQFTNEPVQ----LTPD 566
           D +FT E V      TPD
Sbjct: 323 DPEFTQEAVSKSIGCTPD 340


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  300 bits (767), Expect = 3e-81
 Identities = 158/389 (40%), Positives = 232/389 (59%), Gaps = 27/389 (6%)

Query: 200 VMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRV 259
           ++P  QS    D  Q+ + Y+    E  D+  +++   N            LQDF    V
Sbjct: 616 ILPKSQSEYKPDTPQSGLEYS-GIQELEDRRSQQRFQFN------------LQDFRCCAV 662

Query: 260 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVG 317
           +GRG + KVLL   K T+ ++A+K +KK  +   +++D +  EK +FE  ++  HPFLV 
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722

Query: 318 LHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYR 377
           L +CFQT+  + FV+EY  GGDLM H+       E  A FY+A + L L YLHE  I+YR
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781

Query: 378 DLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWW 437
           DLKLDN+LLD+EG +K+ D+G+CKEG+  GD TSTFCGTP ++APE+L    Y  +VDWW
Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841

Query: 438 ALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
            LGVL++EM+ G SPF           + E+ +F  I+  ++R PR LS +A S+++  L
Sbjct: 842 GLGVLIYEMLVGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892

Query: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
            ++P+ RLG   +    D++ HPFFR +DW  +  K+V PPF P I G   + NFD +FT
Sbjct: 893 RRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951

Query: 558 NE-PVQLTPDDDDIVRKIDQSEFEGFEYI 585
           +E P+   P +  I+ + +Q  F  F+YI
Sbjct: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  294 bits (752), Expect = 2e-79
 Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)

Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
           +E E MN   S   S S  +             DF  L+VIG+GS+ KVLL R K  +  
Sbjct: 64  QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 123

Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
           YA+KV++K+ +   ++   + +E++V  +   HPFLVGLH  FQT  +L+FV++Y+NGG+
Sbjct: 124 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 183

Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
           L +H+QR+R   E  ARFY+AEI+ AL YLH   I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 184 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 243

Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
           CKE +    TTSTFCGTP Y+APE+L  + Y  +VDWW LG +++EM+ G  PF      
Sbjct: 244 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 297

Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
               +NT + ++  IL K +++  +++  A  +L+  L KD  +RLG   +  F +I+ H
Sbjct: 298 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 352

Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
            FF  ++WD +  K++ PPF PN+SG   L +FD +FT EPV      +PD   +   + 
Sbjct: 353 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 412

Query: 576 QS--EFEGFEYINP 587
           ++   F GF Y  P
Sbjct: 413 EAAEAFLGFSYAPP 426


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  294 bits (752), Expect = 2e-79
 Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)

Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
           +E E MN   S   S S  +             DF  L+VIG+GS+ KVLL R K  +  
Sbjct: 78  QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 137

Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
           YA+KV++K+ +   ++   + +E++V  +   HPFLVGLH  FQT  +L+FV++Y+NGG+
Sbjct: 138 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 197

Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
           L +H+QR+R   E  ARFY+AEI+ AL YLH   I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 198 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 257

Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
           CKE +    TTSTFCGTP Y+APE+L  + Y  +VDWW LG +++EM+ G  PF      
Sbjct: 258 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 311

Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
               +NT + ++  IL K +++  +++  A  +L+  L KD  +RLG   +  F +I+ H
Sbjct: 312 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 366

Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
            FF  ++WD +  K++ PPF PN+SG   L +FD +FT EPV      +PD   +   + 
Sbjct: 367 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 426

Query: 576 QS--EFEGFEYINP 587
           ++   F GF Y  P
Sbjct: 427 EAAEAFLGFSYAPP 440


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  294 bits (752), Expect = 2e-79
 Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)

Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
           +E E MN   S   S S  +             DF  L+VIG+GS+ KVLL R K  +  
Sbjct: 92  QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 151

Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
           YA+KV++K+ +   ++   + +E++V  +   HPFLVGLH  FQT  +L+FV++Y+NGG+
Sbjct: 152 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 211

Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
           L +H+QR+R   E  ARFY+AEI+ AL YLH   I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 212 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 271

Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
           CKE +    TTSTFCGTP Y+APE+L  + Y  +VDWW LG +++EM+ G  PF      
Sbjct: 272 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 325

Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
               +NT + ++  IL K +++  +++  A  +L+  L KD  +RLG   +  F +I+ H
Sbjct: 326 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 380

Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
            FF  ++WD +  K++ PPF PN+SG   L +FD +FT EPV      +PD   +   + 
Sbjct: 381 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 440

Query: 576 QS--EFEGFEYINP 587
           ++   F GF Y  P
Sbjct: 441 EAAEAFLGFSYAPP 454


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  294 bits (752), Expect = 2e-79
 Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)

Query: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
           +E E MN   S   S S  +             DF  L+VIG+GS+ KVLL R K  +  
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 218

Query: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
           YA+KV++K+ +   ++   + +E++V  +   HPFLVGLH  FQT  +L+FV++Y+NGG+
Sbjct: 219 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 278

Query: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
           L +H+QR+R   E  ARFY+AEI+ AL YLH   I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 279 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 338

Query: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
           CKE +    TTSTFCGTP Y+APE+L  + Y  +VDWW LG +++EM+ G  PF      
Sbjct: 339 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 392

Query: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
               +NT + ++  IL K +++  +++  A  +L+  L KD  +RLG   +  F +I+ H
Sbjct: 393 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 447

Query: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
            FF  ++WD +  K++ PPF PN+SG   L +FD +FT EPV      +PD   +   + 
Sbjct: 448 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 507

Query: 576 QS--EFEGFEYINP 587
           ++   F GF Y  P
Sbjct: 508 EAAEAFLGFSYAPP 521


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  277 bits (708), Expect = 2e-74
 Identities = 150/379 (39%), Positives = 223/379 (58%), Gaps = 25/379 (6%)

Query: 221 PSSHESLDQVGEEKEA----MNTRES-GKA------SSSLGLQDFDLLRVIGRGSYAKVL 269
           PSS  SL    +E  A      T+E+ G A       S L L+DF  L V+GRG + KVL
Sbjct: 577 PSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVL 636

Query: 270 LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVGLHSCFQTESR 327
           L   + +  ++A+K +KK  +   ++++ +  EK +    ++  HPFLV L  CFQT   
Sbjct: 637 LSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEH 696

Query: 328 LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD 387
           + FV+EY  GGDLM H+       E  A FYSA + L L +LHE  I+YRDLKLDN+LLD
Sbjct: 697 VCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD 755

Query: 388 SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM 447
           +EG++K+ D+G+CKEG+  GD TSTFCGTP ++APE+L    Y  +VDWW LGVL++EM+
Sbjct: 756 TEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML 815

Query: 448 AGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507
            G SPF           + E+ +F  I+  ++R PR LS +A  +++  L ++P+ RLG 
Sbjct: 816 VGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 866

Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE-PVQLTPD 566
             +    D++  PFFR + W+ +  +++ PPF P +SG   + NFD +FT E P    P 
Sbjct: 867 SERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 925

Query: 567 DDDIVRKIDQSEFEGFEYI 585
           D   +   +Q+ F  F+++
Sbjct: 926 DARPLTAAEQAAFLDFDFV 944


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  277 bits (708), Expect = 2e-74
 Identities = 150/379 (39%), Positives = 223/379 (58%), Gaps = 25/379 (6%)

Query: 221 PSSHESLDQVGEEKEA----MNTRES-GKA------SSSLGLQDFDLLRVIGRGSYAKVL 269
           PSS  SL    +E  A      T+E+ G A       S L L+DF  L V+GRG + KVL
Sbjct: 571 PSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVL 630

Query: 270 LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVGLHSCFQTESR 327
           L   + +  ++A+K +KK  +   ++++ +  EK +    ++  HPFLV L  CFQT   
Sbjct: 631 LSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEH 690

Query: 328 LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD 387
           + FV+EY  GGDLM H+       E  A FYSA + L L +LHE  I+YRDLKLDN+LLD
Sbjct: 691 VCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD 749

Query: 388 SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM 447
           +EG++K+ D+G+CKEG+  GD TSTFCGTP ++APE+L    Y  +VDWW LGVL++EM+
Sbjct: 750 TEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML 809

Query: 448 AGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507
            G SPF           + E+ +F  I+  ++R PR LS +A  +++  L ++P+ RLG 
Sbjct: 810 VGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 860

Query: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE-PVQLTPD 566
             +    D++  PFFR + W+ +  +++ PPF P +SG   + NFD +FT E P    P 
Sbjct: 861 SERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 919

Query: 567 DDDIVRKIDQSEFEGFEYI 585
           D   +   +Q+ F  F+++
Sbjct: 920 DARPLTAAEQAAFLDFDFV 938


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,376,014
Number of Sequences: 37866
Number of extensions: 1159884
Number of successful extensions: 5069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 2719
Number of HSP's gapped (non-prelim): 1074
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.