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Search of human proteins with 5174647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 937 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 380 e-105
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 379 e-105
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 374 e-104
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 374 e-104
gi|4503787 fyn-related kinase [Homo sapiens] 370 e-102
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 367 e-102
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 363 e-100
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 357 2e-98
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 357 2e-98
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 357 2e-98
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 349 3e-96
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 345 5e-95
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 345 5e-95
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 336 2e-92
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 336 2e-92
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 330 2e-90
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 320 2e-87
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 288 5e-78
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 288 5e-78
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 288 7e-78
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 288 7e-78
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 288 7e-78
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 288 7e-78
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 288 7e-78
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 261 1e-69
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 261 1e-69
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 261 1e-69
gi|187475373 c-src tyrosine kinase [Homo sapiens] 259 5e-69
gi|4758078 c-src tyrosine kinase [Homo sapiens] 259 5e-69
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 937 bits (2422), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG 60
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG
Sbjct: 1 MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG 60
Query: 61 YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD 120
YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD
Sbjct: 61 YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD 120
Query: 121 TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH 180
TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH
Sbjct: 121 TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH 180
Query: 181 WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK 240
WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK
Sbjct: 181 WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK 240
Query: 241 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM 300
KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM
Sbjct: 241 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM 300
Query: 301 CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS 360
CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS
Sbjct: 301 CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS 360
Query: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM 420
RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM
Sbjct: 361 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM 420
Query: 421 LTCWCRDPEQRPCFKALRERLSSFTSYENPT 451
LTCWCRDPEQRPCFKALRERLSSFTSYENPT
Sbjct: 421 LTCWCRDPEQRPCFKALRERLSSFTSYENPT 451
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 380 bits (975), Expect = e-105
Identities = 194/448 (43%), Positives = 277/448 (61%), Gaps = 15/448 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE----PLPHWDD 183
KI + G ++ F +L +LV ++ ++ RL PC K P + D
Sbjct: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDV 263
Query: 184 WERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 243
WE PRE L ++LG+G FGEV+ G W +VAIK + + + L+ E Q MKKL+
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLK 322
Query: 244 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 303
H ++ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+
Sbjct: 323 HDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
Query: 304 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRG 362
E NYIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
Query: 363 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 422
++ KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
Query: 423 CWCRDPEQRPCFKALRERLSSFTSYENP 450
CW +DPE+RP F+ L+ L + + P
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYFTATEP 529
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 379 bits (973), Expect = e-105
Identities = 198/446 (44%), Positives = 275/446 (61%), Gaps = 14/446 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D+++RT E+LSF+ G+ F + E WW G GY+P NY+A ++
Sbjct: 96 FVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATG---KNGYIPSNYVAPADS 152
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVR-----HY 127
+++E W+FG + R +A R L GN G FL+R SE Y LS+RD +R HY
Sbjct: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHY 212
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
KI + G ++ F +L +LV ++ A L H L P K + + L D WE
Sbjct: 213 KIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAK-DAWE 271
Query: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
PRE L KLG G FGEV+ G W +VAIK + ++ + LQ E Q MKKLRH
Sbjct: 272 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQ-EAQIMKKLRHD 330
Query: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
++ LYAVVS +P+YI+TE M+KGSLL+ L++ D K L + +L+D+A Q+A+GM Y+E
Sbjct: 331 KLVPLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER 389
Query: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
NYIHRDL A NILVGEN +CK+ DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 390 MNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 449
Query: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
+ KSDVWSFGIL E+ ++G+VPYPGM N E +V+ GYRMPCP CP S+H+LM CW
Sbjct: 450 TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 509
Query: 425 CRDPEQRPCFKALRERLSSFTSYENP 450
+DP++RP F+ ++ L + + P
Sbjct: 510 KKDPDERPTFEYIQSFLEDYFTATEP 535
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 374 bits (961), Expect = e-104
Identities = 204/445 (45%), Positives = 272/445 (61%), Gaps = 15/445 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D++SRT+ +LSF+ G+ + E WW G GY+P NY+A ++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT---GYIPSNYVAPSDS 145
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG I+R E+ R L N G FL+R SE Y LSV D V+HY
Sbjct: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
KI + G ++ F SL +LV Y+ A L H L P K + + L D WE
Sbjct: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAK-DAWE 264
Query: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
PRE L KLG G FGEV+ G W +VAIK + + + LQ E Q MKKLRH+
Sbjct: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLRHE 323
Query: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
++ LYAVVS +P+YI+TE M+KGSLL+ L+ K L + +L+D+A Q+A GM Y+E
Sbjct: 324 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
Query: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442
Query: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
+ KSDVWSFGILL E+ ++G+VPYPGM N E +V+ GYRMPCP ECP S+H LM CW
Sbjct: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502
Query: 425 CRDPEQRPCFKALRERLSS-FTSYE 448
++PE+RP F+ L+ L FTS E
Sbjct: 503 RKEPEERPTFEYLQAFLEDYFTSTE 527
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 374 bits (961), Expect = e-104
Identities = 204/445 (45%), Positives = 272/445 (61%), Gaps = 15/445 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D++SRT+ +LSF+ G+ + E WW G GY+P NY+A ++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT---GYIPSNYVAPSDS 145
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG I+R E+ R L N G FL+R SE Y LSV D V+HY
Sbjct: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
KI + G ++ F SL +LV Y+ A L H L P K + + L D WE
Sbjct: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAK-DAWE 264
Query: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
PRE L KLG G FGEV+ G W +VAIK + + + LQ E Q MKKLRH+
Sbjct: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLRHE 323
Query: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
++ LYAVVS +P+YI+TE M+KGSLL+ L+ K L + +L+D+A Q+A GM Y+E
Sbjct: 324 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
Query: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442
Query: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
+ KSDVWSFGILL E+ ++G+VPYPGM N E +V+ GYRMPCP ECP S+H LM CW
Sbjct: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502
Query: 425 CRDPEQRPCFKALRERLSS-FTSYE 448
++PE+RP F+ L+ L FTS E
Sbjct: 503 RKEPEERPTFEYLQAFLEDYFTSTE 527
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 370 bits (951), Expect = e-102
Identities = 201/454 (44%), Positives = 281/454 (61%), Gaps = 15/454 (3%)
Query: 4 RDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARK-EEQWWWATLLD---EAGGAVAQ 59
+ Q H G +V L+D+++RT E+LSFRAGD V E WW+A L+ + Q
Sbjct: 39 QSQRH-GHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97
Query: 60 GYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVR 119
GY+P NY+AE ++++EPWFFG I RS+A ++L N TG+FLIR SE ++ LSV
Sbjct: 98 GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157
Query: 120 DTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHE-PEPL 178
D V+HY+I R G L F +L E V+++ S ++L PC K + P P
Sbjct: 158 DGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPF 217
Query: 179 P----HWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQS 234
D WE R L ++LGSG FGEV+EGLW + VA+K + ++ L+
Sbjct: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR- 276
Query: 235 EIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAW 294
E Q MK LRH ++ LYAV ++ DP+YIITELM GSL E L++ + +++ +D+A
Sbjct: 277 EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAA 336
Query: 295 QVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK---EDVYLS-HDHNIP 350
QVA GM YLES+NYIHRDLAARN+LVGE+ + KV DFGLAR+ K ED+Y S H+ +P
Sbjct: 337 QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP 396
Query: 351 YKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPL 410
KWTAPEA+ +S KSDVWSFGILL+E+ + G++PY GM+ + + YR+P P
Sbjct: 397 VKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPS 456
Query: 411 ECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSF 444
CP + +ML CW +P++RP F+ LR +L +
Sbjct: 457 NCPQQFYNIMLECWNAEPKERPTFETLRWKLEDY 490
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 367 bits (943), Expect = e-102
Identities = 204/432 (47%), Positives = 263/432 (60%), Gaps = 10/432 (2%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAER-- 70
++ L+DF +R ELS R GD + + +A L G + G VP ++A+
Sbjct: 56 FLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS---GQPSAGLVPITHVAKASP 112
Query: 71 ETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIW 130
ET+ +PW+F +SR++A + L + N GAFLIR SE Y LSVR V HY++
Sbjct: 113 ETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVS 172
Query: 131 RRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREE 190
A G L+L + F L EL+ Y++A L PC P+ P D WERP E
Sbjct: 173 MAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM---PQKAPRQDVWERPHSE 229
Query: 191 FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILAL 250
F L RKLG GYFGEV+EGLW + VAIKVI N+ L EIQ +K LRH+ ++ L
Sbjct: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTD-LAKEIQTLKGLRHERLIRL 288
Query: 251 YAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIH 310
+AV S G+PVYI+TELM KG+L L + + L + LL A QVAEGM YLE Q +H
Sbjct: 289 HAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVH 348
Query: 311 RDLAARNILVGENTLCKVGDFGLARLIKEDVYL-SHDHNIPYKWTAPEALSRGHYSTKSD 369
RDLAARN+LV + CKV DFGLARL+K+D+Y S IP KWTAPEA + +S KSD
Sbjct: 349 RDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSD 408
Query: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPE 429
VWSFG+LLHE+F+ GQ PY GM+NHE ++ GYR+P P CP V+ LML CW PE
Sbjct: 409 VWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPE 468
Query: 430 QRPCFKALRERL 441
+RP F LRE+L
Sbjct: 469 ERPSFATLREKL 480
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 363 bits (933), Expect = e-100
Identities = 191/446 (42%), Positives = 272/446 (60%), Gaps = 14/446 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
KI + G ++ F +L +LV ++ +A L L + A + L D WE
Sbjct: 204 KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAK-DAWE 262
Query: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
R L +KLG G F EV+ G W +VAIK + + + L+ E Q MKKL+H
Sbjct: 263 VARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLKHD 321
Query: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
++ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+E
Sbjct: 322 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 380
Query: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
NYIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 381 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 440
Query: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
+ KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+ CW
Sbjct: 441 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 500
Query: 425 CRDPEQRPCFKALRERLSSFTSYENP 450
+DPE+RP F+ L+ L + + P
Sbjct: 501 KKDPEERPTFEYLQSFLEDYFTATEP 526
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 357 bits (915), Expect = 2e-98
Identities = 196/446 (43%), Positives = 275/446 (61%), Gaps = 17/446 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
++ L+D+++RT+++L+F G+ FH+ E WW +G G +P NY+A ++
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT---GCIPSNYVAPVDS 138
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG I R +A R+L + GN GAFLIR SE Y LS+RD V+HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGL--RLAAPCRKHEPEPLPHWDD-W 184
KI + G ++ V F S+ ELV ++ ++ GL L APC +P+ L D W
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHY--MEVNDGLCNLLIAPCTIMKPQTLGLAKDAW 256
Query: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244
E R TL R+LG+G FG+V+ G W +VA+K + + + L+ E Q MK LRH
Sbjct: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE-EAQVMKLLRH 315
Query: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304
++ LYAVVS +P+YI+TE M GSLL+ L++ + + L + +L+D+A QVAEGM Y+E
Sbjct: 316 DKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374
Query: 305 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 363
NYIHRDL A NILVGE CK+ DFGLARLIK+D Y P KWTAPEA G
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434
Query: 364 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 423
++ KSDVWSFGILL E+ ++G++PYPGM+ E +V+ GY MPCP CP S+++ M
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
Query: 424 WCRDPEQRPCFKALRERLSS-FTSYE 448
W DPE+RP F+ L+ L FTS E
Sbjct: 495 WRLDPEERPTFEYLQSFLEDYFTSAE 520
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 357 bits (915), Expect = 2e-98
Identities = 196/446 (43%), Positives = 275/446 (61%), Gaps = 17/446 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
++ L+D+++RT+++L+F G+ FH+ E WW +G G +P NY+A ++
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT---GCIPSNYVAPVDS 138
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG I R +A R+L + GN GAFLIR SE Y LS+RD V+HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGL--RLAAPCRKHEPEPLPHWDD-W 184
KI + G ++ V F S+ ELV ++ ++ GL L APC +P+ L D W
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHY--MEVNDGLCNLLIAPCTIMKPQTLGLAKDAW 256
Query: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244
E R TL R+LG+G FG+V+ G W +VA+K + + + L+ E Q MK LRH
Sbjct: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE-EAQVMKLLRH 315
Query: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304
++ LYAVVS +P+YI+TE M GSLL+ L++ + + L + +L+D+A QVAEGM Y+E
Sbjct: 316 DKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374
Query: 305 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 363
NYIHRDL A NILVGE CK+ DFGLARLIK+D Y P KWTAPEA G
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434
Query: 364 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 423
++ KSDVWSFGILL E+ ++G++PYPGM+ E +V+ GY MPCP CP S+++ M
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
Query: 424 WCRDPEQRPCFKALRERLSS-FTSYE 448
W DPE+RP F+ L+ L FTS E
Sbjct: 495 WRLDPEERPTFEYLQSFLEDYFTSAE 520
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 357 bits (915), Expect = 2e-98
Identities = 196/446 (43%), Positives = 275/446 (61%), Gaps = 17/446 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
++ L+D+++RT+++L+F G+ FH+ E WW +G G +P NY+A ++
Sbjct: 82 FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT---GCIPSNYVAPVDS 138
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG I R +A R+L + GN GAFLIR SE Y LS+RD V+HY
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGL--RLAAPCRKHEPEPLPHWDD-W 184
KI + G ++ V F S+ ELV ++ ++ GL L APC +P+ L D W
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHY--MEVNDGLCNLLIAPCTIMKPQTLGLAKDAW 256
Query: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244
E R TL R+LG+G FG+V+ G W +VA+K + + + L+ E Q MK LRH
Sbjct: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE-EAQVMKLLRH 315
Query: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304
++ LYAVVS +P+YI+TE M GSLL+ L++ + + L + +L+D+A QVAEGM Y+E
Sbjct: 316 DKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374
Query: 305 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 363
NYIHRDL A NILVGE CK+ DFGLARLIK+D Y P KWTAPEA G
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434
Query: 364 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 423
++ KSDVWSFGILL E+ ++G++PYPGM+ E +V+ GY MPCP CP S+++ M
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
Query: 424 WCRDPEQRPCFKALRERLSS-FTSYE 448
W DPE+RP F+ L+ L FTS E
Sbjct: 495 WRLDPEERPTFEYLQSFLEDYFTSAE 520
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 349 bits (896), Expect = 3e-96
Identities = 182/437 (41%), Positives = 272/437 (62%), Gaps = 12/437 (2%)
Query: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
V L+D+++ E+LSF+ GD V + +WW A L +GY+P NY+A +++
Sbjct: 84 VALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL----ATRKEGYIPSNYVARVDSL 139
Query: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQ-----AVRHYK 128
E+E WFF ISR +A R+L A GN G+F+IR SE Y LSVRD V+HYK
Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
Query: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPR 188
I G +++ +F +L ELV++++ + +L+ PC +P+ D WE PR
Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPR 259
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 248
E L +KLG+G FGEV+ + +VA+K + ++ + L +E MK L+H ++
Sbjct: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFL-AEANVMKTLQHDKLV 318
Query: 249 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 308
L+AVV+ +P+YIITE MAKGSLL+ L+ + P+ +L+D + Q+AEGM ++E +NY
Sbjct: 319 KLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 377
Query: 309 IHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYSTK 367
IHRDL A NILV + +CK+ DFGLAR+I+++ Y + + P KWTAPEA++ G ++ K
Sbjct: 378 IHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIK 437
Query: 368 SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRD 427
SDVWSFGILL E+ + G++PYPGMSN E ++ GYRMP P CP ++ +M+ CW
Sbjct: 438 SDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNR 497
Query: 428 PEQRPCFKALRERLSSF 444
PE+RP F+ ++ L F
Sbjct: 498 PEERPTFEYIQSVLDDF 514
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 345 bits (885), Expect = 5e-95
Identities = 181/438 (41%), Positives = 268/438 (61%), Gaps = 14/438 (3%)
Query: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
+ L ++ D +L F G+ + + +WW A L +G++P N++A+ ++
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTG----QEGFIPFNFVAKANSL 122
Query: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT-----QAVRHYK 128
E EPWFF +SR +A R+L A GN G+FLIR SE + + LSVRD + V+HYK
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD-WERP 187
I G +++ ++F L ELV ++ S RL+ PC+ +P+ P W+D WE P
Sbjct: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQK-PWWEDEWEVP 241
Query: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
RE L +LG+G FGEV+ G + +VA+K + + ++ L +E MK+L+H+ +
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL-AEANLMKQLQHQRL 300
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ LYAVV+ +P+YIITE M GSL++ L+ L +++LLD+A Q+AEGM ++E +N
Sbjct: 301 VRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366
YIHRDL A NILV + CK+ DFGLARLI+++ Y + + P KWTAPEA++ G ++
Sbjct: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVWSFGILL E+ + G++PYPGM+N E ++ GYRM P CP +++LM CW
Sbjct: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
Query: 427 DPEQRPCFKALRERLSSF 444
PE RP F LR L F
Sbjct: 480 RPEDRPTFDYLRSVLEDF 497
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 345 bits (885), Expect = 5e-95
Identities = 181/438 (41%), Positives = 268/438 (61%), Gaps = 14/438 (3%)
Query: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
+ L ++ D +L F G+ + + +WW A L +G++P N++A+ ++
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTG----QEGFIPFNFVAKANSL 122
Query: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT-----QAVRHYK 128
E EPWFF +SR +A R+L A GN G+FLIR SE + + LSVRD + V+HYK
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD-WERP 187
I G +++ ++F L ELV ++ S RL+ PC+ +P+ P W+D WE P
Sbjct: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQK-PWWEDEWEVP 241
Query: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
RE L +LG+G FGEV+ G + +VA+K + + ++ L +E MK+L+H+ +
Sbjct: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL-AEANLMKQLQHQRL 300
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ LYAVV+ +P+YIITE M GSL++ L+ L +++LLD+A Q+AEGM ++E +N
Sbjct: 301 VRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366
YIHRDL A NILV + CK+ DFGLARLI+++ Y + + P KWTAPEA++ G ++
Sbjct: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVWSFGILL E+ + G++PYPGM+N E ++ GYRM P CP +++LM CW
Sbjct: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
Query: 427 DPEQRPCFKALRERLSSF 444
PE RP F LR L F
Sbjct: 480 RPEDRPTFDYLRSVLEDF 497
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 336 bits (862), Expect = 2e-92
Identities = 177/449 (39%), Positives = 272/449 (60%), Gaps = 13/449 (2%)
Query: 3 SRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWA-TLLDEAGGAVAQGY 61
++D G V L+ + ++LSF+ G+ V + +WW A +LL + +G+
Sbjct: 37 TKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKK-----EGF 91
Query: 62 VPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT 121
+P NY+A+ T+E+E WFF I+R +A R+L A GN+ GAFLIR SE + LSVRD
Sbjct: 92 IPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDF 151
Query: 122 QAV-----RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE 176
V +HYKI G +++ ++F + +++ +++ Q+ RL C +P+
Sbjct: 152 DPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ 211
Query: 177 PLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEI 236
D WE PRE L ++LG+G FGEV+ G + + +VA+K + + Q L+ E
Sbjct: 212 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLE-EA 270
Query: 237 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQV 296
MK L+H ++ LYAVV+ +P+YIITE MAKGSLL+ L+ + + + +L+D + Q+
Sbjct: 271 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 330
Query: 297 AEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTA 355
AEGM Y+E +NYIHRDL A N+LV E+ +CK+ DFGLAR+I+++ Y + + P KWTA
Sbjct: 331 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 390
Query: 356 PEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPS 415
PEA++ G ++ KSDVWSFGILL+E+ + G++PYPG +N + + GYRMP CP
Sbjct: 391 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 450
Query: 416 VHKLMLTCWCRDPEQRPCFKALRERLSSF 444
++ +M CW E+RP F L+ L F
Sbjct: 451 LYDIMKMCWKEKAEERPTFDYLQSVLDDF 479
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 336 bits (862), Expect = 2e-92
Identities = 177/449 (39%), Positives = 272/449 (60%), Gaps = 13/449 (2%)
Query: 3 SRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWA-TLLDEAGGAVAQGY 61
++D G V L+ + ++LSF+ G+ V + +WW A +LL + +G+
Sbjct: 58 TKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKK-----EGF 112
Query: 62 VPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT 121
+P NY+A+ T+E+E WFF I+R +A R+L A GN+ GAFLIR SE + LSVRD
Sbjct: 113 IPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDF 172
Query: 122 QAV-----RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE 176
V +HYKI G +++ ++F + +++ +++ Q+ RL C +P+
Sbjct: 173 DPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ 232
Query: 177 PLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEI 236
D WE PRE L ++LG+G FGEV+ G + + +VA+K + + Q L+ E
Sbjct: 233 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLE-EA 291
Query: 237 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQV 296
MK L+H ++ LYAVV+ +P+YIITE MAKGSLL+ L+ + + + +L+D + Q+
Sbjct: 292 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 351
Query: 297 AEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTA 355
AEGM Y+E +NYIHRDL A N+LV E+ +CK+ DFGLAR+I+++ Y + + P KWTA
Sbjct: 352 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 411
Query: 356 PEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPS 415
PEA++ G ++ KSDVWSFGILL+E+ + G++PYPG +N + + GYRMP CP
Sbjct: 412 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 471
Query: 416 VHKLMLTCWCRDPEQRPCFKALRERLSSF 444
++ +M CW E+RP F L+ L F
Sbjct: 472 LYDIMKMCWKEKAEERPTFDYLQSVLDDF 500
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 330 bits (846), Expect = 2e-90
Identities = 179/436 (41%), Positives = 256/436 (58%), Gaps = 11/436 (2%)
Query: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
V L+D+ + D +L G+ V + WW A L +GYVP N++A E++
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTG----REGYVPSNFVARVESL 119
Query: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT----QAVRHYKI 129
E E WFF R EA R+L A N G+FLIR SE + LSV+D + ++HYKI
Sbjct: 120 EMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKI 179
Query: 130 WRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPRE 189
G +++ ++F SL LV ++ + RL PC + P+ D+WE PR+
Sbjct: 180 RCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQ 239
Query: 190 EFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILA 249
L RKLGSG FGEV+ G +K+ ++VAIK + + + L E MK L+H+ ++
Sbjct: 240 SLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFL-GEANVMKALQHERLVR 298
Query: 250 LYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYI 309
LYAVV+ +P+YI+TE MA+G LL+ L+ + L + L+D++ Q+AEGM Y+E N I
Sbjct: 299 LYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357
Query: 310 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSD 369
HRDL A NILV E CK+ DFGLAR+I + P KWTAPEA+ G ++ K+D
Sbjct: 358 HRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKAD 417
Query: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK-LMLTCWCRDP 428
VWSFG+LL E+ + G+VPYPGMSN E ++ GYRMP P CPP +++ ++ CW P
Sbjct: 418 VWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRP 477
Query: 429 EQRPCFKALRERLSSF 444
E+RP F+ L+ L F
Sbjct: 478 EERPTFEFLQSVLEDF 493
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 320 bits (820), Expect = 2e-87
Identities = 174/444 (39%), Positives = 249/444 (56%), Gaps = 62/444 (13%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+D+++RT+++LSF G+ F + E WW G GY+P NY+A ++
Sbjct: 87 FVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET---GYIPSNYVAPVDS 143
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
+++E W+FG + R +A R+L + GN G FLIR SE Y LS+RD V+HY
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203
Query: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERP 187
KI + G ++
Sbjct: 204 KIRKLDNGGYYITT---------------------------------------------- 217
Query: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
R +F ++L Y G W +VAIK + + + L+ E Q MKKL+H +
Sbjct: 218 RAQFETLQQLVQHY-----SGTWNGNTKVAIKTLKPGTMSPESFLE-EAQIMKKLKHDKL 271
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ LYAVVS +P+YI+TE M KGSLL+ L+D + + L + L+D+A QVA GM Y+E N
Sbjct: 272 VQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 330
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366
YIHRDL + NILVG +CK+ DFGLARLI+++ Y + P KWTAPEA G ++
Sbjct: 331 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 390
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVWSFGILL E+ ++G+VPYPGM+N E +V+ GYRMPCP +CP S+H+LM+ CW +
Sbjct: 391 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 450
Query: 427 DPEQRPCFKALRERLSSFTSYENP 450
DPE+RP F+ L+ L + + P
Sbjct: 451 DPEERPTFEYLQSFLEDYFTATEP 474
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 288 bits (738), Expect = 5e-78
Identities = 166/434 (38%), Positives = 247/434 (56%), Gaps = 15/434 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V W EA QG+VP NY+ +
Sbjct: 66 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC----EAQTKNGQGWVPSNYITPVNS 121
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SR+ A L + N G+FL+R SE +S+R V HY+I
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAPCRKHEPEPL---PHWDDWERP 187
+ G+L+++ F +L ELV++H A L L AP ++++P P++D WE
Sbjct: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP-KRNKPTVYGVSPNYDKWEME 238
Query: 188 REEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKH 246
R + T+ KLG G +GEV+EG+WK + VA+K + D + ++ L+ E MK+++H +
Sbjct: 239 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPN 297
Query: 247 ILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ 306
++ L V + P YIITE M G+LL+ LR+ + + + LL +A Q++ M YLE +
Sbjct: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
Query: 307 NYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYS 365
N+IHRDLAARN LVGEN L KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
Query: 366 TKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWC 425
KSDVW+FG+LL E+ + G PYPG+ + + ++ YRM P CP V++LM CW
Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
Query: 426 RDPEQRPCFKALRE 439
+P RP F + +
Sbjct: 478 WNPSDRPSFAEIHQ 491
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 288 bits (738), Expect = 5e-78
Identities = 166/434 (38%), Positives = 247/434 (56%), Gaps = 15/434 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V W EA QG+VP NY+ +
Sbjct: 85 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC----EAQTKNGQGWVPSNYITPVNS 140
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SR+ A L + N G+FL+R SE +S+R V HY+I
Sbjct: 141 LEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAPCRKHEPEPL---PHWDDWERP 187
+ G+L+++ F +L ELV++H A L L AP ++++P P++D WE
Sbjct: 199 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP-KRNKPTVYGVSPNYDKWEME 257
Query: 188 REEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKH 246
R + T+ KLG G +GEV+EG+WK + VA+K + D + ++ L+ E MK+++H +
Sbjct: 258 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPN 316
Query: 247 ILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ 306
++ L V + P YIITE M G+LL+ LR+ + + + LL +A Q++ M YLE +
Sbjct: 317 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 376
Query: 307 NYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYS 365
N+IHRDLAARN LVGEN L KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 436
Query: 366 TKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWC 425
KSDVW+FG+LL E+ + G PYPG+ + + ++ YRM P CP V++LM CW
Sbjct: 437 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 496
Query: 426 RDPEQRPCFKALRE 439
+P RP F + +
Sbjct: 497 WNPSDRPSFAEIHQ 510
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 288 bits (737), Expect = 7e-78
Identities = 166/428 (38%), Positives = 244/428 (57%), Gaps = 13/428 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V + W+ + + G QG+VP NY+ +
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG----QGWVPSNYITPVNS 152
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SRS A L + N G+FL+R SE +S+R V HY+I
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAP-CRKHEPEPL-PHWDDWERPR 188
A G++++ F +L ELV++H A L L AP C K + P D WE R
Sbjct: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMER 270
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
+ T+ KLG G +GEV+ G+WK + VA+K + D + ++ L+ E MK+++H ++
Sbjct: 271 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPNL 329
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ L V ++ P YI+TE M G+LL+ LR+ + + + LL +A Q++ M YLE +N
Sbjct: 330 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 389
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
+IHRDLAARN LVGEN + KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 390 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI 449
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVW+FG+LL E+ + G PYPG+ + + ++ GYRM P CPP V++LM CW
Sbjct: 450 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 509
Query: 427 DPEQRPCF 434
P RP F
Sbjct: 510 SPADRPSF 517
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 288 bits (737), Expect = 7e-78
Identities = 166/428 (38%), Positives = 244/428 (57%), Gaps = 13/428 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V + W+ + + G QG+VP NY+ +
Sbjct: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG----QGWVPSNYITPVNS 167
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SRS A L + N G+FL+R SE +S+R V HY+I
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAP-CRKHEPEPL-PHWDDWERPR 188
A G++++ F +L ELV++H A L L AP C K + P D WE R
Sbjct: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMER 285
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
+ T+ KLG G +GEV+ G+WK + VA+K + D + ++ L+ E MK+++H ++
Sbjct: 286 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPNL 344
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ L V ++ P YI+TE M G+LL+ LR+ + + + LL +A Q++ M YLE +N
Sbjct: 345 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 404
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
+IHRDLAARN LVGEN + KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 405 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI 464
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVW+FG+LL E+ + G PYPG+ + + ++ GYRM P CPP V++LM CW
Sbjct: 465 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 524
Query: 427 DPEQRPCF 434
P RP F
Sbjct: 525 SPADRPSF 532
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 288 bits (737), Expect = 7e-78
Identities = 166/428 (38%), Positives = 244/428 (57%), Gaps = 13/428 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V + W+ + + G QG+VP NY+ +
Sbjct: 91 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG----QGWVPSNYITPVNS 146
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SRS A L + N G+FL+R SE +S+R V HY+I
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAP-CRKHEPEPL-PHWDDWERPR 188
A G++++ F +L ELV++H A L L AP C K + P D WE R
Sbjct: 205 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMER 264
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
+ T+ KLG G +GEV+ G+WK + VA+K + D + ++ L+ E MK+++H ++
Sbjct: 265 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPNL 323
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ L V ++ P YI+TE M G+LL+ LR+ + + + LL +A Q++ M YLE +N
Sbjct: 324 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 383
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
+IHRDLAARN LVGEN + KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 384 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI 443
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVW+FG+LL E+ + G PYPG+ + + ++ GYRM P CPP V++LM CW
Sbjct: 444 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 503
Query: 427 DPEQRPCF 434
P RP F
Sbjct: 504 SPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 288 bits (737), Expect = 7e-78
Identities = 166/428 (38%), Positives = 244/428 (57%), Gaps = 13/428 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V + W+ + + G QG+VP NY+ +
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG----QGWVPSNYITPVNS 152
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SRS A L + N G+FL+R SE +S+R V HY+I
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAP-CRKHEPEPL-PHWDDWERPR 188
A G++++ F +L ELV++H A L L AP C K + P D WE R
Sbjct: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMER 270
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
+ T+ KLG G +GEV+ G+WK + VA+K + D + ++ L+ E MK+++H ++
Sbjct: 271 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPNL 329
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ L V ++ P YI+TE M G+LL+ LR+ + + + LL +A Q++ M YLE +N
Sbjct: 330 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 389
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
+IHRDLAARN LVGEN + KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 390 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI 449
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVW+FG+LL E+ + G PYPG+ + + ++ GYRM P CPP V++LM CW
Sbjct: 450 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 509
Query: 427 DPEQRPCF 434
P RP F
Sbjct: 510 SPADRPSF 517
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 288 bits (737), Expect = 7e-78
Identities = 166/428 (38%), Positives = 244/428 (57%), Gaps = 13/428 (3%)
Query: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
+V L+DF + D LS G+ V + W+ + + G QG+VP NY+ +
Sbjct: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG----QGWVPSNYITPVNS 131
Query: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
+E W+ G +SRS A L + N G+FL+R SE +S+R V HY+I
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
Query: 133 AGGRLHLNEAVSFLSLPELVNYHR--AQSLSHGLRLAAP-CRKHEPEPL-PHWDDWERPR 188
A G++++ F +L ELV++H A L L AP C K + P D WE R
Sbjct: 190 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMER 249
Query: 189 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
+ T+ KLG G +GEV+ G+WK + VA+K + D + ++ L+ E MK+++H ++
Sbjct: 250 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK-EAAVMKEIKHPNL 308
Query: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
+ L V ++ P YI+TE M G+LL+ LR+ + + + LL +A Q++ M YLE +N
Sbjct: 309 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 368
Query: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSH-DHNIPYKWTAPEALSRGHYST 366
+IHRDLAARN LVGEN + KV DFGL+RL+ D Y +H P KWTAPE+L+ +S
Sbjct: 369 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI 428
Query: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
KSDVW+FG+LL E+ + G PYPG+ + + ++ GYRM P CPP V++LM CW
Sbjct: 429 KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKW 488
Query: 427 DPEQRPCF 434
P RP F
Sbjct: 489 SPADRPSF 496
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 261 bits (666), Expect = 1e-69
Identities = 164/426 (38%), Positives = 240/426 (56%), Gaps = 21/426 (4%)
Query: 26 ELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEP------WF 79
EL+FR GDV + E W + G +G + L ERE + ++P WF
Sbjct: 25 ELAFRKGDVVTILEACENKSWYRVKHHTSGQ--EGLLAAGALREREALSADPKLSLMPWF 82
Query: 80 FGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139
G IS EAV++LQ + G FL+R S + DYVL V + V HY++ R G L +
Sbjct: 83 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHR-DGHLTI 139
Query: 140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHW---DDWERPREEFTLCRK 196
+EAV F +L ++V ++ + +L P RKH + W + TL +
Sbjct: 140 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 199
Query: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256
+G G FG V +G + + +VA+K I D + Q E M K++H++++ L V+ +
Sbjct: 200 IGEGEFGAVLQGEYLGQ-KVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVI-L 255
Query: 257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAAR 316
+YI+ E ++KG+L+ LR ++ ++LL + VAEGM YLES+ +HRDLAAR
Sbjct: 256 HQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 315
Query: 317 NILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGIL 376
NILV E+ + KV DFGLA+ ++ + S +P KWTAPEAL G +++KSDVWSFG+L
Sbjct: 316 NILVSEDLVAKVSDFGLAKAERKGLDSSR---LPVKWTAPEALKHGKFTSKSDVWSFGVL 372
Query: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKA 436
L E+FS G+ PYP MS E V+ GYRM P CP VH LM +CW +P +RP F+
Sbjct: 373 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK 432
Query: 437 LRERLS 442
L E+L+
Sbjct: 433 LAEKLA 438
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 261 bits (666), Expect = 1e-69
Identities = 164/426 (38%), Positives = 240/426 (56%), Gaps = 21/426 (4%)
Query: 26 ELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEP------WF 79
EL+FR GDV + E W + G +G + L ERE + ++P WF
Sbjct: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQ--EGLLAAGALREREALSADPKLSLMPWF 124
Query: 80 FGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139
G IS EAV++LQ + G FL+R S + DYVL V + V HY++ R G L +
Sbjct: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHR-DGHLTI 181
Query: 140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHW---DDWERPREEFTLCRK 196
+EAV F +L ++V ++ + +L P RKH + W + TL +
Sbjct: 182 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 241
Query: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256
+G G FG V +G + + +VA+K I D + Q E M K++H++++ L V+ +
Sbjct: 242 IGEGEFGAVLQGEYLGQ-KVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVI-L 297
Query: 257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAAR 316
+YI+ E ++KG+L+ LR ++ ++LL + VAEGM YLES+ +HRDLAAR
Sbjct: 298 HQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 357
Query: 317 NILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGIL 376
NILV E+ + KV DFGLA+ ++ + S +P KWTAPEAL G +++KSDVWSFG+L
Sbjct: 358 NILVSEDLVAKVSDFGLAKAERKGLDSSR---LPVKWTAPEALKHGKFTSKSDVWSFGVL 414
Query: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKA 436
L E+FS G+ PYP MS E V+ GYRM P CP VH LM +CW +P +RP F+
Sbjct: 415 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK 474
Query: 437 LRERLS 442
L E+L+
Sbjct: 475 LAEKLA 480
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 261 bits (666), Expect = 1e-69
Identities = 164/426 (38%), Positives = 240/426 (56%), Gaps = 21/426 (4%)
Query: 26 ELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEP------WF 79
EL+FR GDV + E W + G +G + L ERE + ++P WF
Sbjct: 66 ELAFRKGDVVTILEACENKSWYRVKHHTSGQ--EGLLAAGALREREALSADPKLSLMPWF 123
Query: 80 FGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139
G IS EAV++LQ + G FL+R S + DYVL V + V HY++ R G L +
Sbjct: 124 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHR-DGHLTI 180
Query: 140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHW---DDWERPREEFTLCRK 196
+EAV F +L ++V ++ + +L P RKH + W + TL +
Sbjct: 181 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 240
Query: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256
+G G FG V +G + + +VA+K I D + Q E M K++H++++ L V+ +
Sbjct: 241 IGEGEFGAVLQGEYLGQ-KVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVI-L 296
Query: 257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAAR 316
+YI+ E ++KG+L+ LR ++ ++LL + VAEGM YLES+ +HRDLAAR
Sbjct: 297 HQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 356
Query: 317 NILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGIL 376
NILV E+ + KV DFGLA+ ++ + S +P KWTAPEAL G +++KSDVWSFG+L
Sbjct: 357 NILVSEDLVAKVSDFGLAKAERKGLDSSR---LPVKWTAPEALKHGKFTSKSDVWSFGVL 413
Query: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKA 436
L E+FS G+ PYP MS E V+ GYRM P CP VH LM +CW +P +RP F+
Sbjct: 414 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK 473
Query: 437 LRERLS 442
L E+L+
Sbjct: 474 LAEKLA 479
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 259 bits (661), Expect = 5e-69
Identities = 168/451 (37%), Positives = 239/451 (52%), Gaps = 26/451 (5%)
Query: 10 GPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAE 69
G + + ++F +++L F GDV + + W ++ G +G +P NY+ +
Sbjct: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVG---REGIIPANYVQK 67
Query: 70 RETVESE------PWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA 123
RE V++ PWF G I+R +A R L TG FL+R S DY L V
Sbjct: 68 REGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGK 125
Query: 124 VRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD 183
V HY+I A +L ++E V F +L +LV ++ + + RL P K + D+
Sbjct: 126 VEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP--KVMEGTVAAQDE 182
Query: 184 -----WERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQA 238
W +E L + +G G FG+V G ++ +VA+K I D Q +E
Sbjct: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA--QAFLAEASV 239
Query: 239 MKKLRHKHILALYAV-VSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVA 297
M +LRH +++ L V V +YI+TE MAKGSL++ LR VL LL + V
Sbjct: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299
Query: 298 EGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE 357
E M YLE N++HRDLAARN+LV E+ + KV DFGL KE +P KWTAPE
Sbjct: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPE 356
Query: 358 ALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVH 417
AL +STKSDVWSFGILL E++S G+VPYP + + RV+ GY+M P CPP+V+
Sbjct: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416
Query: 418 KLMLTCWCRDPEQRPCFKALRERLSSFTSYE 448
++M CW D RP F LRE+L ++E
Sbjct: 417 EVMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 259 bits (661), Expect = 5e-69
Identities = 168/451 (37%), Positives = 239/451 (52%), Gaps = 26/451 (5%)
Query: 10 GPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAE 69
G + + ++F +++L F GDV + + W ++ G +G +P NY+ +
Sbjct: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVG---REGIIPANYVQK 67
Query: 70 RETVESE------PWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA 123
RE V++ PWF G I+R +A R L TG FL+R S DY L V
Sbjct: 68 REGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGK 125
Query: 124 VRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD 183
V HY+I A +L ++E V F +L +LV ++ + + RL P K + D+
Sbjct: 126 VEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP--KVMEGTVAAQDE 182
Query: 184 -----WERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQA 238
W +E L + +G G FG+V G ++ +VA+K I D Q +E
Sbjct: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA--QAFLAEASV 239
Query: 239 MKKLRHKHILALYAV-VSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVA 297
M +LRH +++ L V V +YI+TE MAKGSL++ LR VL LL + V
Sbjct: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299
Query: 298 EGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE 357
E M YLE N++HRDLAARN+LV E+ + KV DFGL KE +P KWTAPE
Sbjct: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPE 356
Query: 358 ALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVH 417
AL +STKSDVWSFGILL E++S G+VPYP + + RV+ GY+M P CPP+V+
Sbjct: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416
Query: 418 KLMLTCWCRDPEQRPCFKALRERLSSFTSYE 448
++M CW D RP F LRE+L ++E
Sbjct: 417 EVMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,298,931
Number of Sequences: 37866
Number of extensions: 853200
Number of successful extensions: 4450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 283
Number of HSP's that attempted gapping in prelim test: 2011
Number of HSP's gapped (non-prelim): 1262
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.